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Sample records for automatic conformation prediction

  1. Shape: automatic conformation prediction of carbohydrates using a genetic algorithm

    Directory of Open Access Journals (Sweden)

    Rosen Jimmy

    2009-09-01

    Full Text Available Abstract Background Detailed experimental three dimensional structures of carbohydrates are often difficult to acquire. Molecular modelling and computational conformation prediction are therefore commonly used tools for three dimensional structure studies. Modelling procedures generally require significant training and computing resources, which is often impractical for most experimental chemists and biologists. Shape has been developed to improve the availability of modelling in this field. Results The Shape software package has been developed for simplicity of use and conformation prediction performance. A trivial user interface coupled to an efficient genetic algorithm conformation search makes it a powerful tool for automated modelling. Carbohydrates up to a few hundred atoms in size can be investigated on common computer hardware. It has been shown to perform well for the prediction of over four hundred bioactive oligosaccharides, as well as compare favourably with previously published studies on carbohydrate conformation prediction. Conclusion The Shape fully automated conformation prediction can be used by scientists who lack significant modelling training, and performs well on computing hardware such as laptops and desktops. It can also be deployed on computer clusters for increased capacity. The prediction accuracy under the default settings is good, as it agrees well with experimental data and previously published conformation prediction studies. This software is available both as open source and under commercial licenses.

  2. Automatically predicting mood from expressed emotions

    NARCIS (Netherlands)

    Katsimerou, C.

    2016-01-01

    Affect-adaptive systems have the potential to assist users that experience systematically negative moods. This thesis aims at building a platform for predicting automatically a person’s mood from his/her visual expressions. The key word is mood, namely a relatively long-term, stable and diffused aff

  3. Automatically predicting mood from expressed emotions

    OpenAIRE

    Katsimerou, C.

    2016-01-01

    Affect-adaptive systems have the potential to assist users that experience systematically negative moods. This thesis aims at building a platform for predicting automatically a person’s mood from his/her visual expressions. The key word is mood, namely a relatively long-term, stable and diffused affective state, as opposed to the short-term, volatile and intense emotion. This is emphasized, because mood and emotion often tend to be used as synonyms. However, since their differences are well e...

  4. Fitmunk: improving protein structures by accurate, automatic modeling of side-chain conformations.

    Science.gov (United States)

    Porebski, Przemyslaw Jerzy; Cymborowski, Marcin; Pasenkiewicz-Gierula, Marta; Minor, Wladek

    2016-02-01

    Improvements in crystallographic hardware and software have allowed automated structure-solution pipelines to approach a near-`one-click' experience for the initial determination of macromolecular structures. However, in many cases the resulting initial model requires a laborious, iterative process of refinement and validation. A new method has been developed for the automatic modeling of side-chain conformations that takes advantage of rotamer-prediction methods in a crystallographic context. The algorithm, which is based on deterministic dead-end elimination (DEE) theory, uses new dense conformer libraries and a hybrid energy function derived from experimental data and prior information about rotamer frequencies to find the optimal conformation of each side chain. In contrast to existing methods, which incorporate the electron-density term into protein-modeling frameworks, the proposed algorithm is designed to take advantage of the highly discriminatory nature of electron-density maps. This method has been implemented in the program Fitmunk, which uses extensive conformational sampling. This improves the accuracy of the modeling and makes it a versatile tool for crystallographic model building, refinement and validation. Fitmunk was extensively tested on over 115 new structures, as well as a subset of 1100 structures from the PDB. It is demonstrated that the ability of Fitmunk to model more than 95% of side chains accurately is beneficial for improving the quality of crystallographic protein models, especially at medium and low resolutions. Fitmunk can be used for model validation of existing structures and as a tool to assess whether side chains are modeled optimally or could be better fitted into electron density. Fitmunk is available as a web service at http://kniahini.med.virginia.edu/fitmunk/server/ or at http://fitmunk.bitbucket.org/. PMID:26894674

  5. Fitmunk: improving protein structures by accurate, automatic modeling of side-chain conformations.

    Science.gov (United States)

    Porebski, Przemyslaw Jerzy; Cymborowski, Marcin; Pasenkiewicz-Gierula, Marta; Minor, Wladek

    2016-02-01

    Improvements in crystallographic hardware and software have allowed automated structure-solution pipelines to approach a near-`one-click' experience for the initial determination of macromolecular structures. However, in many cases the resulting initial model requires a laborious, iterative process of refinement and validation. A new method has been developed for the automatic modeling of side-chain conformations that takes advantage of rotamer-prediction methods in a crystallographic context. The algorithm, which is based on deterministic dead-end elimination (DEE) theory, uses new dense conformer libraries and a hybrid energy function derived from experimental data and prior information about rotamer frequencies to find the optimal conformation of each side chain. In contrast to existing methods, which incorporate the electron-density term into protein-modeling frameworks, the proposed algorithm is designed to take advantage of the highly discriminatory nature of electron-density maps. This method has been implemented in the program Fitmunk, which uses extensive conformational sampling. This improves the accuracy of the modeling and makes it a versatile tool for crystallographic model building, refinement and validation. Fitmunk was extensively tested on over 115 new structures, as well as a subset of 1100 structures from the PDB. It is demonstrated that the ability of Fitmunk to model more than 95% of side chains accurately is beneficial for improving the quality of crystallographic protein models, especially at medium and low resolutions. Fitmunk can be used for model validation of existing structures and as a tool to assess whether side chains are modeled optimally or could be better fitted into electron density. Fitmunk is available as a web service at http://kniahini.med.virginia.edu/fitmunk/server/ or at http://fitmunk.bitbucket.org/.

  6. Prediction of PARP Inhibition with Proteochemometric Modelling and Conformal Prediction.

    Science.gov (United States)

    Cortés-Ciriano, Isidro; Bender, Andreas; Malliavin, Thérèse

    2015-06-01

    Poly(ADP-ribose) polymerases (PARPs) play a key role in DNA damage repair. PARP inhibitors act as chemo- and radio- sensitizers and thus potentiate the cytotoxicity of DNA damaging agents. Although PARP inhibitors are currently investigated as chemotherapeutic agents, their cross-reactivity with other members of the PARP family remains unclear. Here, we apply Proteochemometric Modelling (PCM) to model the activity of 181 compounds on 12 human PARPs. We demonstrate that PCM (R0 (2) test =0.65-0.69; RMSEtest =0.95-1.01 °C) displays higher performance on the test set (interpolation) than Family QSAR and Family QSAM (Tukey's HSD, α 0.05), and outperforms Inductive Transfer knowledge among targets (Tukey's HSD, α 0.05). We benchmark the predictive signal of 8 amino acid and 11 full-protein sequence descriptors, obtaining that all of them (except for SOCN) perform at the same level of statistical significance (Tukey's HSD, α 0.05). The extrapolation power of PCM to new compounds (RMSE=1.02±0.80 °C) and targets (RMSE=1.03±0.50 °C) is comparable to interpolation, although the extrapolation ability is not uniform across the chemical and the target space. For this reason, we also provide confidence intervals calculated with conformal prediction. In addition, we present the R package conformal, which permits the calculation of confidence intervals for regression and classification caret models. PMID:27490382

  7. Conformal prediction for reliable machine learning theory, adaptations and applications

    CERN Document Server

    Balasubramanian, Vineeth; Vovk, Vladimir

    2014-01-01

    The conformal predictions framework is a recent development in machine learning that can associate a reliable measure of confidence with a prediction in any real-world pattern recognition application, including risk-sensitive applications such as medical diagnosis, face recognition, and financial risk prediction. Conformal Predictions for Reliable Machine Learning: Theory, Adaptations and Applications captures the basic theory of the framework, demonstrates how to apply it to real-world problems, and presents several adaptations, including active learning, change detection, and anomaly detecti

  8. Predicting protein ligand binding motions with the conformation explorer

    Directory of Open Access Journals (Sweden)

    Flores Samuel C

    2011-10-01

    Full Text Available Abstract Background Knowledge of the structure of proteins bound to known or potential ligands is crucial for biological understanding and drug design. Often the 3D structure of the protein is available in some conformation, but binding the ligand of interest may involve a large scale conformational change which is difficult to predict with existing methods. Results We describe how to generate ligand binding conformations of proteins that move by hinge bending, the largest class of motions. First, we predict the location of the hinge between domains. Second, we apply an Euler rotation to one of the domains about the hinge point. Third, we compute a short-time dynamical trajectory using Molecular Dynamics to equilibrate the protein and ligand and correct unnatural atomic positions. Fourth, we score the generated structures using a novel fitness function which favors closed or holo structures. By iterating the second through fourth steps we systematically minimize the fitness function, thus predicting the conformational change required for small ligand binding for five well studied proteins. Conclusions We demonstrate that the method in most cases successfully predicts the holo conformation given only an apo structure.

  9. Improved chemical shift prediction by Rosetta conformational sampling

    Energy Technology Data Exchange (ETDEWEB)

    Tian Ye [Sanford Burnham Medical Research Institute (United States); Opella, Stanley J. [University of California San Diego, Department of Chemistry and Biochemistry (United States); Marassi, Francesca M., E-mail: fmarassi@sbmri.org [Sanford Burnham Medical Research Institute (United States)

    2012-11-15

    Chemical shift frequencies represent a time-average of all the conformational states populated by a protein. Thus, chemical shift prediction programs based on sequence and database analysis yield higher accuracy for rigid rather than flexible protein segments. Here we show that the prediction accuracy can be significantly improved by averaging over an ensemble of structures, predicted solely from amino acid sequence with the Rosetta program. This approach to chemical shift and structure prediction has the potential to be useful for guiding resonance assignments, especially in solid-state NMR structural studies of membrane proteins in proteoliposomes.

  10. Nonlinear model predictive control using automatic differentiation

    OpenAIRE

    Al Seyab, Rihab Khalid Shakir

    2006-01-01

    Although nonlinear model predictive control (NMPC) might be the best choice for a nonlinear plant, it is still not widely used. This is mainly due to the computational burden associated with solving online a set of nonlinear differential equations and a nonlinear dynamic optimization problem in real time. This thesis is concerned with strategies aimed at reducing the computational burden involved in different stages of the NMPC such as optimization problem, state estimation, an...

  11. Automatic processing of an orientation map into a finite element mesh that conforms to grain boundaries

    Science.gov (United States)

    Dancette, S.; Browet, A.; Martin, G.; Willemet, M.; Delannay, L.

    2016-06-01

    A new procedure for microstructure-based finite element modeling of polycrystalline aggregates is presented. The proposed method relies (i) on an efficient graph-based community detection algorithm for crystallographic data segmentation and feature contour extraction and (ii) on the generation of selectively refined meshes conforming to grain boundaries. It constitutes a versatile and close to automatic environment for meshing complex microstructures. The procedure is illustrated with polycrystal microstructures characterized by orientation imaging microscopy. Hot deformation of a Duplex stainless steel is investigated based on ex-situ EBSD measurements performed on the same region of interest before and after deformation. A finite element mesh representing the initial microstructure is generated and then used in a crystal plasticity simulation of the plane strain compression. Simulation results and experiments are in relatively good agreement, confirming a large potential for such directly coupled experimental and modeling analyses, which is facilitated by the present image-based meshing procedure.

  12. Automatic prediction of facial trait judgments: appearance vs. structural models.

    Directory of Open Access Journals (Sweden)

    Mario Rojas

    Full Text Available Evaluating other individuals with respect to personality characteristics plays a crucial role in human relations and it is the focus of attention for research in diverse fields such as psychology and interactive computer systems. In psychology, face perception has been recognized as a key component of this evaluation system. Multiple studies suggest that observers use face information to infer personality characteristics. Interactive computer systems are trying to take advantage of these findings and apply them to increase the natural aspect of interaction and to improve the performance of interactive computer systems. Here, we experimentally test whether the automatic prediction of facial trait judgments (e.g. dominance can be made by using the full appearance information of the face and whether a reduced representation of its structure is sufficient. We evaluate two separate approaches: a holistic representation model using the facial appearance information and a structural model constructed from the relations among facial salient points. State of the art machine learning methods are applied to a derive a facial trait judgment model from training data and b predict a facial trait value for any face. Furthermore, we address the issue of whether there are specific structural relations among facial points that predict perception of facial traits. Experimental results over a set of labeled data (9 different trait evaluations and classification rules (4 rules suggest that a prediction of perception of facial traits is learnable by both holistic and structural approaches; b the most reliable prediction of facial trait judgments is obtained by certain type of holistic descriptions of the face appearance; and c for some traits such as attractiveness and extroversion, there are relationships between specific structural features and social perceptions.

  13. Ligand-induced conformational changes: Improved predictions of ligand binding conformations and affinities

    DEFF Research Database (Denmark)

    Frimurer, T.M.; Peters, Günther H.J.; Iversen, L.F.;

    2003-01-01

    A computational docking strategy using multiple conformations of the target protein is discussed and evaluated. A series of low molecular weight, competitive, nonpeptide protein tyrosine phosphatase inhibitors are considered for which the x-ray crystallographic structures in complex with protein...... tyrosine phosphatase 1 B (PTP1B) are known. To obtain a quantitative measure of the impact of conformational changes induced by the inhibitors, these were docked to the active site region of various structures of PTP1B using the docking program FlexX. Firstly, the inhibitors were docked to a PTP1B crystal...... with low estimated binding energies corresponded to relatively large RMS differences when aligned with the corresponding crystal structure. Secondly, the inhibitors were docked to their parent protein structures in which they were cocrystallized. In this case, there was a good correlation between low...

  14. Does human presynaptic striatal dopamine function predict social conformity?

    OpenAIRE

    Stokes, Paul; Benecke, Aaf; Puraite, Julita; Bloomfield, Michael Ap; Shotbolt, Paul; Reeves, Suzanne; Lingford-Hughes, Anne R.; Howes, Oliver; Egerton, Alice

    2014-01-01

    Socially desirable responding (SDR) is a personality trait which reflects either a tendency to present oneself in an overly positive manner to others, consistent with social conformity (impression management (IM)), or the tendency to view one's own behaviour in an overly positive light (self-deceptive enhancement (SDE)). Neurochemical imaging studies report an inverse relationship between SDR and dorsal striatal dopamine D2/3 receptor availability. This may reflect an association between SDR ...

  15. Does human presynaptic striatal dopamine function predict social conformity?

    Science.gov (United States)

    Stokes, Paul R A; Benecke, Aaf; Puraite, Julita; Bloomfield, Michael A P; Shotbolt, Paul; Reeves, Suzanne J; Lingford-Hughes, Anne R; Howes, Oliver; Egerton, Alice

    2014-03-01

    Socially desirable responding (SDR) is a personality trait which reflects either a tendency to present oneself in an overly positive manner to others, consistent with social conformity (impression management (IM)), or the tendency to view one's own behaviour in an overly positive light (self-deceptive enhancement (SDE)). Neurochemical imaging studies report an inverse relationship between SDR and dorsal striatal dopamine D₂/₃ receptor availability. This may reflect an association between SDR and D₂/₃ receptor expression, synaptic dopamine levels or a combination of the two. In this study, we used a [¹⁸F]-DOPA positron emission tomography (PET) image database to investigate whether SDR is associated with presynaptic dopamine function. Striatal [¹⁸F]-DOPA uptake, (k(i)(cer), min⁻¹), was determined in two independent healthy participant cohorts (n=27 and 19), by Patlak analysis using a cerebellar reference region. SDR was assessed using the revised Eysenck Personality Questionnaire (EPQ-R) Lie scale, and IM and SDE were measured using the Paulhus Deception Scales. No significant associations were detected between Lie, SDE or IM scores and striatal [¹⁸F]-DOPA k(i)(cer). These results indicate that presynaptic striatal dopamine function is not associated with social conformity and suggests that social conformity may be associated with striatal D₂/₃ receptor expression rather than with synaptic dopamine levels.

  16. Lynx: Automatic Elderly Behavior Prediction in Home Telecare

    Science.gov (United States)

    Lopez-Guede, Jose Manuel; Moreno-Fernandez-de-Leceta, Aitor; Martinez-Garcia, Alexeiw; Graña, Manuel

    2015-01-01

    This paper introduces Lynx, an intelligent system for personal safety at home environments, oriented to elderly people living independently, which encompasses a decision support machine for automatic home risk prevention, tested in real-life environments to respond to real time situations. The automatic system described in this paper prevents such risks by an advanced analytic methods supported by an expert knowledge system. It is minimally intrusive, using plug-and-play sensors and machine learning algorithms to learn the elder's daily activity taking into account even his health records. If the system detects that something unusual happens (in a wide sense) or if something is wrong relative to the user's health habits or medical recommendations, it sends at real-time alarm to the family, care center, or medical agents, without human intervention. The system feeds on information from sensors deployed in the home and knowledge of subject physical activities, which can be collected by mobile applications and enriched by personalized health information from clinical reports encoded in the system. The system usability and reliability have been tested in real-life conditions, with an accuracy larger than 81%. PMID:26783514

  17. Lynx: Automatic Elderly Behavior Prediction in Home Telecare

    Directory of Open Access Journals (Sweden)

    Jose Manuel Lopez-Guede

    2015-01-01

    Full Text Available This paper introduces Lynx, an intelligent system for personal safety at home environments, oriented to elderly people living independently, which encompasses a decision support machine for automatic home risk prevention, tested in real-life environments to respond to real time situations. The automatic system described in this paper prevents such risks by an advanced analytic methods supported by an expert knowledge system. It is minimally intrusive, using plug-and-play sensors and machine learning algorithms to learn the elder’s daily activity taking into account even his health records. If the system detects that something unusual happens (in a wide sense or if something is wrong relative to the user’s health habits or medical recommendations, it sends at real-time alarm to the family, care center, or medical agents, without human intervention. The system feeds on information from sensors deployed in the home and knowledge of subject physical activities, which can be collected by mobile applications and enriched by personalized health information from clinical reports encoded in the system. The system usability and reliability have been tested in real-life conditions, with an accuracy larger than 81%.

  18. Disjoint combinations profiling (DCP): a new method for the prediction of antibody CDR conformation from sequence.

    Science.gov (United States)

    Nikoloudis, Dimitris; Pitts, Jim E; Saldanha, José W

    2014-01-01

    The accurate prediction of the conformation of Complementarity-Determining Regions (CDRs) is important in modelling antibodies for protein engineering applications. Specifically, the Canonical paradigm has proved successful in predicting the CDR conformation in antibody variable regions. It relies on canonical templates which detail allowed residues at key positions in the variable region framework or in the CDR itself for 5 of the 6 CDRs. While no templates have as yet been defined for the hypervariable CDR-H3, instead, reliable sequence rules have been devised for predicting the base of the CDR-H3 loop. Here a new method termed Disjoint Combinations Profiling (DCP) is presented, which contributes a considerable advance in the prediction of CDR conformations. This novel method is explained and compared with canonical templates and sequence rules in a 3-way blind prediction. DCP achieved 93% accuracy over 951 blind predictions and showed an improvement in cumulative accuracy compared to predictions with canonical templates or sequence rules. In addition to its overall improvement in prediction accuracy, it is suggested that DCP is open to better implementations in the future and that it can improve as more antibody structures are deposited in the databank. In contrast, it is argued that canonical templates and sequence rules may have reached their peak. PMID:25071985

  19. Disjoint combinations profiling (DCP): a new method for the prediction of antibody CDR conformation from sequence.

    Science.gov (United States)

    Nikoloudis, Dimitris; Pitts, Jim E; Saldanha, José W

    2014-01-01

    The accurate prediction of the conformation of Complementarity-Determining Regions (CDRs) is important in modelling antibodies for protein engineering applications. Specifically, the Canonical paradigm has proved successful in predicting the CDR conformation in antibody variable regions. It relies on canonical templates which detail allowed residues at key positions in the variable region framework or in the CDR itself for 5 of the 6 CDRs. While no templates have as yet been defined for the hypervariable CDR-H3, instead, reliable sequence rules have been devised for predicting the base of the CDR-H3 loop. Here a new method termed Disjoint Combinations Profiling (DCP) is presented, which contributes a considerable advance in the prediction of CDR conformations. This novel method is explained and compared with canonical templates and sequence rules in a 3-way blind prediction. DCP achieved 93% accuracy over 951 blind predictions and showed an improvement in cumulative accuracy compared to predictions with canonical templates or sequence rules. In addition to its overall improvement in prediction accuracy, it is suggested that DCP is open to better implementations in the future and that it can improve as more antibody structures are deposited in the databank. In contrast, it is argued that canonical templates and sequence rules may have reached their peak.

  20. Disjoint combinations profiling (DCP: a new method for the prediction of antibody CDR conformation from sequence

    Directory of Open Access Journals (Sweden)

    Dimitris Nikoloudis

    2014-07-01

    Full Text Available The accurate prediction of the conformation of Complementarity-Determining Regions (CDRs is important in modelling antibodies for protein engineering applications. Specifically, the Canonical paradigm has proved successful in predicting the CDR conformation in antibody variable regions. It relies on canonical templates which detail allowed residues at key positions in the variable region framework or in the CDR itself for 5 of the 6 CDRs. While no templates have as yet been defined for the hypervariable CDR-H3, instead, reliable sequence rules have been devised for predicting the base of the CDR-H3 loop. Here a new method termed Disjoint Combinations Profiling (DCP is presented, which contributes a considerable advance in the prediction of CDR conformations. This novel method is explained and compared with canonical templates and sequence rules in a 3-way blind prediction. DCP achieved 93% accuracy over 951 blind predictions and showed an improvement in cumulative accuracy compared to predictions with canonical templates or sequence rules. In addition to its overall improvement in prediction accuracy, it is suggested that DCP is open to better implementations in the future and that it can improve as more antibody structures are deposited in the databank. In contrast, it is argued that canonical templates and sequence rules may have reached their peak.

  1. Dosimetric validation for an automatic brain metastases planning software using single-isocenter dynamic conformal arcsDosimetric validation for an automatic brain metastases planning software using single-isocenter dynamic conformal arcs.

    Science.gov (United States)

    Liu, Haisong; Li, Jun; Pappas, Evangelos; Andrews, David; Evans, James; Werner-Wasik, Maria; Yu, Yan; Dicker, Adam; Shi, Wenyin

    2016-01-01

    An automatic brain-metastases planning (ABMP) software has been installed in our institution. It is dedicated for treating multiple brain metastases with radiosurgery on linear accelerators (linacs) using a single-setup isocenter with noncoplanar dynamic conformal arcs. This study is to validate the calculated absolute dose and dose distribution of ABMP. Three types of measurements were performed to validate the planning software: 1, dual micro ion chambers were used with an acrylic phantom to measure the absolute dose; 2, a 3D cylindrical phantom with dual diode array was used to evaluate 2D dose distribution and point dose for smaller targets; and 3, a 3D pseudo-in vivo patient-specific phantom filled with polymer gels was used to evaluate the accuracy of 3D dose distribution and radia-tion delivery. Micro chamber measurement of two targets (volumes of 1.2 cc and 0.9 cc, respectively) showed that the percentage differences of the absolute dose at both targets were less than 1%. Averaged GI passing rate of five different plans measured with the diode array phantom was above 98%, using criteria of 3% dose difference, 1 mm distance to agreement (DTA), and 10% low-dose threshold. 3D gel phantom measurement results demonstrated a 3D displacement of nine targets of 0.7 ± 0.4 mm (range 0.2 ~ 1.1 mm). The averaged two-dimensional (2D) GI passing rate for several region of interests (ROI) on axial slices that encompass each one of the nine targets was above 98% (5% dose difference, 2 mm DTA, and 10% low-dose threshold). Measured D95, the minimum dose that covers 95% of the target volume, of the nine targets was 0.7% less than the calculated D95. Three different types of dosimetric verification methods were used and proved the dose calculation of the new automatic brain metastases planning (ABMP) software was clinical acceptable. The 3D pseudo-in vivo patient-specific gel phantom test also served as an end-to-end test for validating not only the dose calculation, but the

  2. Learned predictiveness influences automatic evaluations in human contingency learning

    NARCIS (Netherlands)

    Le Pelley, M. E.; Calvini, G.; Spears, R.

    2013-01-01

    Experiments used an affective priming procedure to investigate whether evaluative conditioning in humans is subject to bias as a consequence of differences in the learned predictiveness of the cues involved. Experiment 1, using brief prime presentation, demonstrated stronger affective priming for cu

  3. Predicting most probable conformations of a given peptide sequence in the random coil state.

    Science.gov (United States)

    Bayrak, Cigdem Sevim; Erman, Burak

    2012-11-01

    In this work, we present a computational scheme for finding high probability conformations of peptides. The scheme calculates the probability of a given conformation of the given peptide sequence using the probability distribution of torsion states. Dependence of the states of a residue on the states of its first neighbors along the chain is considered. Prior probabilities of torsion states are obtained from a coil library. Posterior probabilities are calculated by the matrix multiplication Rotational Isomeric States Model of polymer theory. The conformation of a peptide with highest probability is determined by using a hidden Markov model Viterbi algorithm. First, the probability distribution of the torsion states of the residues is obtained. Using the highest probability torsion state, one can generate, step by step, states with lower probabilities. To validate the method, the highest probability state of residues in a given sequence is calculated and compared with probabilities obtained from the Coil Databank. Predictions based on the method are 32% better than predictions based on the most probable states of residues. The ensemble of "n" high probability conformations of a given protein is also determined using the Viterbi algorithm with multistep backtracking. PMID:22955874

  4. Automatic Prediction of Cardiovascular and Cerebrovascular Events Using Heart Rate Variability Analysis

    OpenAIRE

    Melillo, Paolo; Izzo, Raffaele; Orrico, Ada; Scala, Paolo; Attanasio, Marcella; Mirra, Marco; De Luca, Nicola; Pecchia, Leandro

    2015-01-01

    Background There is consensus that Heart Rate Variability is associated with the risk of vascular events. However, Heart Rate Variability predictive value for vascular events is not completely clear. The aim of this study is to develop novel predictive models based on data-mining algorithms to provide an automatic risk stratification tool for hypertensive patients. Methods A database of 139 Holter recordings with clinical data of hypertensive patients followed up for at least 12 months were c...

  5. Performance prediction of four-contact vertical Hall-devices using a conformal mapping technique

    International Nuclear Information System (INIS)

    Instead of the conventional design with five contacts in the sensor active area, innovative vertical Hall devices (VHDs) with four contacts and six contacts are asymmetrical in structural design but symmetrical in the current flow that can be well fit for the spinning current technique for offset elimination. In this article, a conformal mapping calculation method is used to predict the performance of asymmetrical VHD embedded in a deep n-well with four contacts. Furthermore, to make the calculation more accurate, the junction field effect is also involved into the conformal mapping method. The error between calculated and simulated results is less than 5% for the current-related sensitivity, and approximately 13% for the voltage-related sensitivity. This proves that such calculations can be used to predict the optimal structure of the vertical Hall-devices. (paper)

  6. Improved docking, screening and selectivity prediction for small molecule nuclear receptor modulators using conformational ensembles

    OpenAIRE

    Park, So-Jung; Kufareva, Irina; Abagyan, Ruben

    2010-01-01

    Nuclear receptors (NRs) are ligand dependent transcriptional factors and play a key role in reproduction, development, and homeostasis of organism. NRs are potential targets for treatment of cancer and other diseases such as inflammatory diseases, and diabetes. In this study, we present a comprehensive library of pocket conformational ensembles of thirteen human nuclear receptors (NRs), and test the ability of these ensembles to recognize their ligands in virtual screening, as well as predict...

  7. Assessment of Protein Side-Chain Conformation Prediction Methods in Different Residue Environments

    Science.gov (United States)

    Peterson, Lenna X.; Kang, Xuejiao; Kihara, Daisuke

    2016-01-01

    Computational prediction of side-chain conformation is an important component of protein structure prediction. Accurate side-chain prediction is crucial for practical applications of protein structure models that need atomic detailed resolution such as protein and ligand design. We evaluated the accuracy of eight side-chain prediction methods in reproducing the side-chain conformations of experimentally solved structures deposited to the Protein Data Bank. Prediction accuracy was evaluated for a total of four different structural environments (buried, surface, interface, and membrane-spanning) in three different protein types (monomeric, multimeric, and membrane). Overall, the highest accuracy was observed for buried residues in monomeric and multimeric proteins. Notably, side-chains at protein interfaces and membrane-spanning regions were better predicted than surface residues even though the methods did not all use multimeric and membrane proteins for training. Thus, we conclude that the current methods are as practically useful for modeling protein docking interfaces and membrane-spanning regions as for modeling monomers. PMID:24619909

  8. Homology Modeling and Conformational Epitope Prediction of Envelope Protein of Alkhumra Haemorrhagic Fever Virus

    Directory of Open Access Journals (Sweden)

    Naghmeh Poorinmohammad

    2015-10-01

    Full Text Available Background: The aim of this study was to generate in silico 3D-structure of the envelope protein of AHFV using homology modeling method to further predict its conformational epitopes and help other studies to investigate itsstructural features using the model.Methods: A 3D-structure prediction was developed for the envelope protein of Alkhumra haemorrhagic fever virus (AHFV, an emerging tick-borne flavivirus, based on a homology modeling method using M4T and Modwebservers, as the 3D-structure of the protein is not available yet. Modeled proteins were validated using Modfold 4 server and their accuracies were calculated based on their RSMDs. Having the 3D predicted model with high quality, conformational epitopes were predicted using DiscoTope 2.0.Results: Model generated by M4T was more acceptable than the Modweb-generated model. The global score and Pvalue calculated by Modfold 4 ensured that a certifiable model was generated by M4T, since its global score was almost near 1 which is the score for a high resolution X-ray crystallography structure. Furthermore, itsthe P-value was much lower than 0.001 which means that the model is completely acceptable. Having 0.46 Å rmsd, this model was shown to be highly accurate. Results from DiscoTope 2.0 showed 26 residues as epitopes, forming conformational epitopes of the modeled protein.Conclusion: The predicted model and epitopes for envelope protein of AHFV can be used in several therapeutic and diagnostic approaches including peptide vaccine development, structure based drug design or diagnostic kit development in order to facilitate the time consuming experimental epitope mapping process.

  9. Switch region for pathogenic structural change in conformational disease and its prediction.

    Directory of Open Access Journals (Sweden)

    Xin Liu

    Full Text Available Many diseases are believed to be related to abnormal protein folding. In the first step of such pathogenic structural changes, misfolding occurs in regions important for the stability of the native structure. This destabilizes the normal protein conformation, while exposing the previously hidden aggregation-prone regions, leading to subsequent errors in the folding pathway. Sites involved in this first stage can be deemed switch regions of the protein, and can represent perfect binding targets for drugs to block the abnormal folding pathway and prevent pathogenic conformational changes. In this study, a prediction algorithm for the switch regions responsible for the start of pathogenic structural changes is introduced. With an accuracy of 94%, this algorithm can successfully find short segments covering sites significant in triggering conformational diseases (CDs and is the first that can predict switch regions for various CDs. To illustrate its effectiveness in dealing with urgent public health problems, the reason of the increased pathogenicity of H5N1 influenza virus is analyzed; the mechanisms of the pandemic swine-origin 2009 A(H1N1 influenza virus in overcoming species barriers and in infecting large number of potential patients are also suggested. It is shown that the algorithm is a potential tool useful in the study of the pathology of CDs because: (1 it can identify the origin of pathogenic structural conversion with high sensitivity and specificity, and (2 it provides an ideal target for clinical treatment.

  10. Prediction of extubation outcome: a randomised, controlled trial with automatic tube compensation vs. pressure support ventilation

    OpenAIRE

    Cohen, Jonathan; Shapiro, Maury; Grozovski, Elad; Fox, Ben; Lev, Shaul; Singer, Pierre

    2009-01-01

    Introduction Tolerance of a spontaneous breathing trial is an evidence-based strategy to predict successful weaning from mechanical ventilation. Some patients may not tolerate the trial because of the respiratory load imposed by the endotracheal tube, so varying levels of respiratory support are widely used during the trial. Automatic tube compensation (ATC), specifically developed to overcome the imposed work of breathing because of artificial airways, appears ideally suited for the weaning ...

  11. Face Prediction Model for an Automatic Age-invariant Face Recognition System

    OpenAIRE

    Yadav, Poonam

    2015-01-01

    Automated face recognition and identification softwares are becoming part of our daily life; it finds its abode not only with Facebook's auto photo tagging, Apple's iPhoto, Google's Picasa, Microsoft's Kinect, but also in Homeland Security Department's dedicated biometric face detection systems. Most of these automatic face identification systems fail where the effects of aging come into the picture. Little work exists in the literature on the subject of face prediction that accounts for agin...

  12. Automatic prediction of cardiovascular and cerebrovascular events using heart rate variability analysis.

    Directory of Open Access Journals (Sweden)

    Paolo Melillo

    Full Text Available There is consensus that Heart Rate Variability is associated with the risk of vascular events. However, Heart Rate Variability predictive value for vascular events is not completely clear. The aim of this study is to develop novel predictive models based on data-mining algorithms to provide an automatic risk stratification tool for hypertensive patients.A database of 139 Holter recordings with clinical data of hypertensive patients followed up for at least 12 months were collected ad hoc. Subjects who experienced a vascular event (i.e., myocardial infarction, stroke, syncopal event were considered as high-risk subjects. Several data-mining algorithms (such as support vector machine, tree-based classifier, artificial neural network were used to develop automatic classifiers and their accuracy was tested by assessing the receiver-operator characteristics curve. Moreover, we tested the echographic parameters, which have been showed as powerful predictors of future vascular events.The best predictive model was based on random forest and enabled to identify high-risk hypertensive patients with sensitivity and specificity rates of 71.4% and 87.8%, respectively. The Heart Rate Variability based classifier showed higher predictive values than the conventional echographic parameters, which are considered as significant cardiovascular risk factors.Combination of Heart Rate Variability measures, analyzed with data-mining algorithm, could be a reliable tool for identifying hypertensive patients at high risk to develop future vascular events.

  13. Conformal house

    DEFF Research Database (Denmark)

    Ryttov, Thomas Aaby; Sannino, Francesco

    2010-01-01

    fixed point. As a consistency check we recover the previously investigated bounds of the conformal windows when restricting to a single matter representation. The earlier conformal windows can be imagined to be part now of the new conformal house. We predict the nonperturbative anomalous dimensions...... at the infrared fixed points. We further investigate the effects of adding mass terms to the condensates on the conformal house chiral dynamics and construct the simplest instanton induced effective Lagrangian terms...

  14. Prediction of protein secondary structure based on residue pair types and conformational states using dynamic programming algorithm.

    Science.gov (United States)

    Sadeghi, Mehdi; Parto, Sahar; Arab, Shahriar; Ranjbar, Bijan

    2005-06-20

    We have used a statistical approach for protein secondary structure prediction based on information theory and simultaneously taking into consideration pairwise residue types and conformational states. Since the prediction of residue secondary structure by one residue window sliding make ambiguity in state prediction, we used a dynamic programming algorithm to find the path with maximum score. A score system for residue pairs in particular conformations is derived for adjacent neighbors up to ten residue apart in sequence. The three state overall per-residue accuracy, Q3, of this method in a jackknife test with dataset created from PDBSELECT is more than 70%. PMID:15936021

  15. Elucidating Hyperconjugation from Electronegativity to Predict Drug Conformational Energy in a High Throughput Manner.

    Science.gov (United States)

    Liu, Zhaomin; Pottel, Joshua; Shahamat, Moeed; Tomberg, Anna; Labute, Paul; Moitessier, Nicolas

    2016-04-25

    Computational chemists use structure-based drug design and molecular dynamics of drug/protein complexes which require an accurate description of the conformational space of drugs. Organic chemists use qualitative chemical principles such as the effect of electronegativity on hyperconjugation, the impact of steric clashes on stereochemical outcome of reactions, and the consequence of resonance on the shape of molecules to rationalize experimental observations. While computational chemists speak about electron densities and molecular orbitals, organic chemists speak about partial charges and localized molecular orbitals. Attempts to reconcile these two parallel approaches such as programs for natural bond orbitals and intrinsic atomic orbitals computing Lewis structures-like orbitals and reaction mechanism have appeared. In the past, we have shown that encoding and quantifying chemistry knowledge and qualitative principles can lead to predictive methods. In the same vein, we thought to understand the conformational behaviors of molecules and to encode this knowledge back into a molecular mechanics tool computing conformational potential energy and to develop an alternative to atom types and training of force fields on large sets of molecules. Herein, we describe a conceptually new approach to model torsion energies based on fundamental chemistry principles. To demonstrate our approach, torsional energy parameters were derived on-the-fly from atomic properties. When the torsional energy terms implemented in GAFF, Parm@Frosst, and MMFF94 were substituted by our method, the accuracy of these force fields to reproduce MP2-derived torsional energy profiles and their transferability to a variety of functional groups and drug fragments were overall improved. In addition, our method did not rely on atom types and consequently did not suffer from poor automated atom type assignments. PMID:27028941

  16. [Prediction of Protein Conformational Mobility and Evaluation of Its Reliability Using Small-Angle X-ray Scattering].

    Science.gov (United States)

    Knyazev, S N; Kalyakin, V Y; Deryabin, I N; Fedorov, B A; Smirnov, A V; Stepanov, E O; Porozov, Yu B

    2015-01-01

    The "coarse-grained" model of protein conformational mobility is presented. We compared the trajectories of conformational motions predicted for five proteins using this model with the motion obtained by the method of the "nearest neighbor", based on small-angle X-ray scattering data. It is shown that for all studied proteins the sequence of conformations calculated on the basis of "coarse-grained" model and on the basis of the "nearest neighbor", coincides well, although there are exceptions. Some separate consideration should be given to each protein to discern the causes of these exceptions. PMID:26841499

  17. COMPUTER-BASED PREDICTION OF TOXICITY USING THE ELECTRON-CONFORMATIONAL METHOD. APPLICATION TO FRAGRANCE ALLERGENS AND OTHER ENVIRONMENTAL POLLUTANTS

    OpenAIRE

    Natalia N. Gorinchoy; Isaac B. Bersuker

    2012-01-01

    The electron-conformational (EC) method is employed for the toxicophore (Tph) identification and quantitative prediction of toxicity using the training set of 24 compounds that are considered as fragrance allergens. The values of a=LD50 in oral exposure of rats were chosen as a measure of toxicity. EC parameters are evaluated on the base of conformational analysis and ab initio electronic structure calculations (including solvent influence). The Tph consists of four sites which in this ser...

  18. Lipid tail protrusion in simulations predicts fusogenic activity of influenza fusion peptide mutants and conformational models.

    Directory of Open Access Journals (Sweden)

    Per Larsson

    Full Text Available Fusion peptides from influenza hemagglutinin act on membranes to promote membrane fusion, but the mechanism by which they do so remains unknown. Recent theoretical work has suggested that contact of protruding lipid tails may be an important feature of the transition state for membrane fusion. If this is so, then influenza fusion peptides would be expected to promote tail protrusion in proportion to the ability of the corresponding full-length hemagglutinin to drive lipid mixing in fusion assays. We have performed molecular dynamics simulations of influenza fusion peptides in lipid bilayers, comparing the X-31 influenza strain against a series of N-terminal mutants. As hypothesized, the probability of lipid tail protrusion correlates well with the lipid mixing rate induced by each mutant. This supports the conclusion that tail protrusion is important to the transition state for fusion. Furthermore, it suggests that tail protrusion can be used to examine how fusion peptides might interact with membranes to promote fusion. Previous models for native influenza fusion peptide structure in membranes include a kinked helix, a straight helix, and a helical hairpin. Our simulations visit each of these conformations. Thus, the free energy differences between each are likely low enough that specifics of the membrane environment and peptide construct may be sufficient to modulate the equilibrium between them. However, the kinked helix promotes lipid tail protrusion in our simulations much more strongly than the other two structures. We therefore predict that the kinked helix is the most fusogenic of these three conformations.

  19. An Automatic Prediction of Epileptic Seizures Using Cloud Computing and Wireless Sensor Networks.

    Science.gov (United States)

    Sareen, Sanjay; Sood, Sandeep K; Gupta, Sunil Kumar

    2016-11-01

    Epilepsy is one of the most common neurological disorders which is characterized by the spontaneous and unforeseeable occurrence of seizures. An automatic prediction of seizure can protect the patients from accidents and save their life. In this article, we proposed a mobile-based framework that automatically predict seizures using the information contained in electroencephalography (EEG) signals. The wireless sensor technology is used to capture the EEG signals of patients. The cloud-based services are used to collect and analyze the EEG data from the patient's mobile phone. The features from the EEG signal are extracted using the fast Walsh-Hadamard transform (FWHT). The Higher Order Spectral Analysis (HOSA) is applied to FWHT coefficients in order to select the features set relevant to normal, preictal and ictal states of seizure. We subsequently exploit the selected features as input to a k-means classifier to detect epileptic seizure states in a reasonable time. The performance of the proposed model is tested on Amazon EC2 cloud and compared in terms of execution time and accuracy. The findings show that with selected HOS based features, we were able to achieve a classification accuracy of 94.6 %. PMID:27628727

  20. An Automatic Prediction of Epileptic Seizures Using Cloud Computing and Wireless Sensor Networks.

    Science.gov (United States)

    Sareen, Sanjay; Sood, Sandeep K; Gupta, Sunil Kumar

    2016-11-01

    Epilepsy is one of the most common neurological disorders which is characterized by the spontaneous and unforeseeable occurrence of seizures. An automatic prediction of seizure can protect the patients from accidents and save their life. In this article, we proposed a mobile-based framework that automatically predict seizures using the information contained in electroencephalography (EEG) signals. The wireless sensor technology is used to capture the EEG signals of patients. The cloud-based services are used to collect and analyze the EEG data from the patient's mobile phone. The features from the EEG signal are extracted using the fast Walsh-Hadamard transform (FWHT). The Higher Order Spectral Analysis (HOSA) is applied to FWHT coefficients in order to select the features set relevant to normal, preictal and ictal states of seizure. We subsequently exploit the selected features as input to a k-means classifier to detect epileptic seizure states in a reasonable time. The performance of the proposed model is tested on Amazon EC2 cloud and compared in terms of execution time and accuracy. The findings show that with selected HOS based features, we were able to achieve a classification accuracy of 94.6 %.

  1. Foot and leg conformation traits have a small effect on genomic predictions of claw disorders in Norwegian Red cows.

    Science.gov (United States)

    Ødegård, C; Svendsen, M; Heringstad, B

    2015-06-01

    The aim of this study was to evaluate whether the predictive correlation of genomic breeding values (GEBV) for claw disorders increased by including genetically correlated traits as additional information in the analyses. Predictive correlations of GEBV for claw disorders were calculated based on claw disorders only and by analyzing claw disorders together with genetically correlated foot and leg conformation traits. The claw disorders analyzed were corkscrew claw (CSC); infectious claw disorder, including dermatitis, heel horn erosion, and interdigital phlegmon; and laminitis-related claw disorder, including sole ulcer, white line disorder, and hemorrhage of sole and white line. The foot and leg conformation traits included were hoof quality, foot angle, rear leg rear view new, and rear leg rear view old. The data consisted of 183,728 daughters with claw health records and 421,319 daughters with foot and leg conformation scores. A 25K/54K single nucleotide polymorphism (SNP) data set containing 48,249 SNP was available for the analyses. The number of genotyped sires with daughter information in the analyses was 1,093 including claw disorders and 3,111 including claw disorders and foot and leg conformation traits. Predictive correlations of GEBV for CSC, infectious claw disorder, and laminitis-related claw disorder were calculated from a 10-fold cross-validation and from an additional validation set including the youngest sires. Only sires having daughters with claw health records were in the validation sets, thus increasing the reference population when adding foot and leg conformation traits. The results showed marginal improvement in the predictive correlation of GEBV for CSC when including hoof quality and foot angle, both in 10-fold cross-validation (from 0.35 to 0.37) and in the validation including the youngest sires (from 0.38 to 0.49). For infectious claw disorder and laminitis-related claw disorder, including foot and leg conformation traits had no effect

  2. Enthalpy/Entropy Contributions to Conformational KIEs: Theoretical Predictions and Comparison with Experiment

    Directory of Open Access Journals (Sweden)

    Aaron Fong

    2013-02-01

    Full Text Available Previous theoretical studies of Mislow’s doubly-bridged biphenyl ketone 1 and dihydrodimethylphenanthrene 2 have determined significant entropic contributions to their normal (1 and inverse (2 conformational kinetic isotope effects (CKIEs. To broaden our investigation, we have used density functional methods to characterize the potential energy surfaces and vibrational frequencies for ground and transition structures of additional systems with measured CKIEs, including [2.2]-metaparacyclophane-d (3, 1,1'-binaphthyl (4, 2,2'-dibromo-[1,1'-biphenyl]-4,4'-dicarboxylic acid (5, and the 2-(N,N,N-trimethyl-2'-(N,N-dimethyl-diaminobiphenyl cation (6. We have also computed CKIEs in a number of systems whose experimental CKIEs are unknown. These include analogs of 1 in which the C=O groups have been replaced with CH2 (7, O (8, and S (9 atoms and ring-expanded variants of 2 containing CH2 (10, O (11, S (12, or C=O (13 groups. Vibrational entropy contributes to the CKIEs in all of these systems with the exception of cyclophane 3, whose isotope effect is predicted to be purely enthalpic in origin and whose Bigeleisen-Mayer ZPE term is equivalent to ΔΔ H‡. There is variable correspondence between these terms in the other molecules studied, thus identifying additional examples of systems in which the Bigeleisen-Mayer formalism does not correlate with ΔH/ΔS dissections.

  3. UniCon3D: de novo protein structure prediction using united-residue conformational search via stepwise, probabilistic sampling

    Science.gov (United States)

    Bhattacharya, Debswapna; Cao, Renzhi; Cheng, Jianlin

    2016-01-01

    Motivation: Recent experimental studies have suggested that proteins fold via stepwise assembly of structural units named ‘foldons’ through the process of sequential stabilization. Alongside, latest developments on computational side based on probabilistic modeling have shown promising direction to perform de novo protein conformational sampling from continuous space. However, existing computational approaches for de novo protein structure prediction often randomly sample protein conformational space as opposed to experimentally suggested stepwise sampling. Results: Here, we develop a novel generative, probabilistic model that simultaneously captures local structural preferences of backbone and side chain conformational space of polypeptide chains in a united-residue representation and performs experimentally motivated conditional conformational sampling via stepwise synthesis and assembly of foldon units that minimizes a composite physics and knowledge-based energy function for de novo protein structure prediction. The proposed method, UniCon3D, has been found to (i) sample lower energy conformations with higher accuracy than traditional random sampling in a small benchmark of 6 proteins; (ii) perform comparably with the top five automated methods on 30 difficult target domains from the 11th Critical Assessment of Protein Structure Prediction (CASP) experiment and on 15 difficult target domains from the 10th CASP experiment; and (iii) outperform two state-of-the-art approaches and a baseline counterpart of UniCon3D that performs traditional random sampling for protein modeling aided by predicted residue-residue contacts on 45 targets from the 10th edition of CASP. Availability and Implementation: Source code, executable versions, manuals and example data of UniCon3D for Linux and OSX are freely available to non-commercial users at http://sysbio.rnet.missouri.edu/UniCon3D/. Contact: chengji@missouri.edu Supplementary information: Supplementary data are

  4. Automatic Construction of Predictive Neuron Models through Large Scale Assimilation of Electrophysiological Data

    Science.gov (United States)

    Nogaret, Alain; Meliza, C. Daniel; Margoliash, Daniel; Abarbanel, Henry D. I.

    2016-09-01

    We report on the construction of neuron models by assimilating electrophysiological data with large-scale constrained nonlinear optimization. The method implements interior point line parameter search to determine parameters from the responses to intracellular current injections of zebra finch HVC neurons. We incorporated these parameters into a nine ionic channel conductance model to obtain completed models which we then use to predict the state of the neuron under arbitrary current stimulation. Each model was validated by successfully predicting the dynamics of the membrane potential induced by 20-50 different current protocols. The dispersion of parameters extracted from different assimilation windows was studied. Differences in constraints from current protocols, stochastic variability in neuron output, and noise behave as a residual temperature which broadens the global minimum of the objective function to an ellipsoid domain whose principal axes follow an exponentially decaying distribution. The maximum likelihood expectation of extracted parameters was found to provide an excellent approximation of the global minimum and yields highly consistent kinetics for both neurons studied. Large scale assimilation absorbs the intrinsic variability of electrophysiological data over wide assimilation windows. It builds models in an automatic manner treating all data as equal quantities and requiring minimal additional insight.

  5. Predicting automaticity in exercise behaviour: the role of perceived behavioural control, affect, intention, action planning, and behaviour

    NARCIS (Netherlands)

    G.J. de Bruijn; B. Gardner; L. van Osch; F.F. Sniehotta

    2014-01-01

    Background Habit formation has been proposed as a way to maintain behaviour over time. Purpose Recent evidence suggests that constructs additional to repeated performance may predict physical automaticity, but no research has yet explored possible direct impacts of intention, planning, affect, and p

  6. Radiation dosimetry predicts IQ after conformal radiation therapy in pediatric patients with localized ependymoma

    International Nuclear Information System (INIS)

    Purpose: To assess the effects of radiation dose-volume distribution on the trajectory of IQ development after conformal radiation therapy (CRT) in pediatric patients with ependymoma. Methods and Materials: The study included 88 patients (median age, 2.8 years ± 4.5 years) with localized ependymoma who received CRT (54-59.4 Gy) that used a 1-cm margin on the postoperative tumor bed. Patients were evaluated with tests that included IQ measures at baseline (before CRT) and at 6, 12, 24, 36, 48, and 60 months. Differential dose-volume histograms (DVH) were derived for total-brain, supratentorial-brain, and right and left temporal-lobe volumes. The data were partitioned into three dose intervals and integrated to create variables that represent the fractional volume that received dose over the specified intervals (e.g., V0-20Gy, V20-40Gy, V40-65Gy) and modeled with clinical variables to develop a regression equation to estimate IQ after CRT. Results: A total of 327 IQ tests were performed in 66 patients with infratentorial tumors and 20 with supratentorial tumors. The median follow-up was 29.4 months. For all patients, IQ was best estimated by age (years) at CRT; percent volume of the supratentorial brain that received doses between 0 and 20 Gy, 20 and 40 Gy, and 40 and 65 Gy; and time (months) after CRT. Age contributed significantly to the intercept (p > 0.0001), and the dose-volume coefficients were statistically significant (V0-20Gy, p = 0.01; V20-40Gy, p 40-65Gy, p = 0.04). A similar model was developed exclusively for patients with infratentorial tumors but not supratentorial tumors. Conclusion: Radiation dosimetry can be used to predict IQ after CRT in patients with localized ependymoma. The specificity of models may be enhanced by grouping according to tumor location

  7. COMPUTER-BASED PREDICTION OF TOXICITY USING THE ELECTRON-CONFORMATIONAL METHOD. APPLICATION TO FRAGRANCE ALLERGENS AND OTHER ENVIRONMENTAL POLLUTANTS

    Directory of Open Access Journals (Sweden)

    Natalia N. Gorinchoy

    2012-06-01

    Full Text Available The electron-conformational (EC method is employed for the toxicophore (Tph identification and quantitative prediction of toxicity using the training set of 24 compounds that are considered as fragrance allergens. The values of a=LD50 in oral exposure of rats were chosen as a measure of toxicity. EC parameters are evaluated on the base of conformational analysis and ab initio electronic structure calculations (including solvent influence. The Tph consists of four sites which in this series of compounds are represented by three carbon and one oxygen atoms, but may be any other atoms that have the same electronic and geometric features within the tolerance limits. The regression model taking into consideration the Tph flexibility, anti-Tph shielding, and influence of out-of-Tph functional groups predicts well the experimental values of toxicity (R2 = 0.93 with a reasonable leaveone- out cross-validation.

  8. A revised automated proximity and conformity analysis method to compare predicted and observed spatial boundaries of geologic phenomena

    Science.gov (United States)

    Li, Yingkui; Napieralski, Jacob; Harbor, Jon

    2008-12-01

    Quantitative assessment of the level of agreement between model-predicted and field-observed geologic data is crucial to calibrate and validate numerical landscape models. Application of Geographic Information Systems (GIS) provides an opportunity to integrate model and field data and quantify their levels of correspondence. Napieralski et al. [Comparing predicted and observed spatial boundaries of geologic phenomena: Automated Proximity and Conformity Analysis (APCA) applied to ice sheet reconstructions. Computers and Geosciences 32, 124-134] introduced an Automated Proximity and Conformity Analysis (APCA) method to compare model-predicted and field-observed spatial boundaries and used it to quantify the level of correspondence between predicted ice margins from ice sheet models and field observations from end moraines. However, as originally formulated, APCA involves a relatively large amount of user intervention during the analysis and results in an index to quantify the level of correspondence that lacks direct statistical meaning. Here, we propose a revised APCA approach and a more automated and statistically robust way to quantify the level of correspondence between model predictions and field observations. Specifically, the mean and standard deviation of distances between model and field boundaries are used to quantify proximity and conformity, respectively. An illustration of the revised method comparing modeled ice margins of the Fennoscandian Ice Sheet with observed end moraines of the Last Glacial Maximum shows that this approach provides a more automated and statistically robust means to quantify correspondence than the original APCA. The revised approach can be adopted for a wide range of geoscience issues where comparisons of model-predicted and field-observed spatial boundaries are useful, including mass movement and flood extents.

  9. Doing Gender for Different Reasons: Why Gender Conformity Positively and Negatively Predicts Self-Esteem

    Science.gov (United States)

    Good, Jessica J.; Sanchez, Diana T.

    2010-01-01

    Past research has shown that valuing gender conformity is associated with both positive and negative consequences for self-esteem and positive affect. The current research (women, n= 226; men, n= 175) explored these conflicting findings by separating out investing in societal gender ideals from personally valuing one's gender identity ("private…

  10. Predicting three-dimensional conformations of peptides constructed of only glycine, alanine, aspartic acid, and valine.

    Science.gov (United States)

    Oda, Akifumi; Fukuyoshi, Shuichi

    2015-06-01

    The GADV hypothesis is a form of the protein world hypothesis, which suggests that life originated from proteins (Lacey et al. 1999; Ikehara 2002; Andras 2006). In the GADV hypothesis, life is thought to have originated from primitive proteins constructed of only glycine, alanine, aspartic acid, and valine ([GADV]-proteins). In this study, the three-dimensional (3D) conformations of randomly generated short [GADV]-peptides were computationally investigated using replica-exchange molecular dynamics (REMD) simulations (Sugita and Okamoto 1999). Because the peptides used in this study consisted of only 20 residues each, they could not form certain 3D structures. However, the conformational tendencies of the peptides were elucidated by analyzing the conformational ensembles generated by REMD simulations. The results indicate that secondary structures can be formed in several randomly generated [GADV]-peptides. A long helical structure was found in one of the hydrophobic peptides, supporting the conjecture of the GADV hypothesis that many peptides aggregated to form peptide multimers with enzymatic activity in the primordial soup. In addition, these results indicate that REMD simulations can be used for the structural investigation of short peptides.

  11. Predicting Three-Dimensional Conformations of Peptides Constructed of Only Glycine, Alanine, Aspartic Acid, and Valine

    Science.gov (United States)

    Oda, Akifumi; Fukuyoshi, Shuichi

    2015-06-01

    The GADV hypothesis is a form of the protein world hypothesis, which suggests that life originated from proteins (Lacey et al. 1999; Ikehara 2002; Andras 2006). In the GADV hypothesis, life is thought to have originated from primitive proteins constructed of only glycine, alanine, aspartic acid, and valine ([GADV]-proteins). In this study, the three-dimensional (3D) conformations of randomly generated short [GADV]-peptides were computationally investigated using replica-exchange molecular dynamics (REMD) simulations (Sugita and Okamoto 1999). Because the peptides used in this study consisted of only 20 residues each, they could not form certain 3D structures. However, the conformational tendencies of the peptides were elucidated by analyzing the conformational ensembles generated by REMD simulations. The results indicate that secondary structures can be formed in several randomly generated [GADV]-peptides. A long helical structure was found in one of the hydrophobic peptides, supporting the conjecture of the GADV hypothesis that many peptides aggregated to form peptide multimers with enzymatic activity in the primordial soup. In addition, these results indicate that REMD simulations can be used for the structural investigation of short peptides.

  12. Comparing predicted and observed spatial boundaries of geologic phenomena: Automated Proximity and Conformity Analysis applied to ice sheet reconstructions

    Science.gov (United States)

    Napieralski, Jacob; Li, Yingkui; Harbor, Jon

    2006-02-01

    Comparing predicted with observed geologic data is a central element of many aspects of research in the geosciences, e.g., comparing numerical ice sheet models with geomorphic data to test ice sheet model parameters and accuracy. However, the ability to verify predictions using empirical data has been limited by the lack of objective techniques that provide systematic comparison and statistical assessment of the goodness of correspondence between predictions of spatial and temporal patterns of geologic phenomena and the field evidence. Much of this problem arises from the inability to quantify the level of agreement between straight or curvilinear features, such as between the modeled extent of some geologic phenomenon and the field evidence for the extent of the phenomenon. Automated Proximity and Conformity Analysis (APCA) addresses this challenge using a system of Geographic Information System-based buffering that determines the general proximity and parallel conformity between linear features. APCA results indicate which modeled output fits empirical data, based on the distance and angle between features. As a result, various model outputs can be sorted according to overall level of agreement by comparison with one or multiple features from field evidence, based on proximity and conformity values. In an example application drawn from glacial geomorphology, APCA is integrated into an overall model verification process that includes matching modeled ice sheets to known marginal positions and ice flow directions, among other parameters. APCA is not limited to ice sheet or glacier models, but can be applied to many geoscience areas where the extent or geometry of modeled results need to be compared against field observations, such as debris flows, tsunami run-out, lava flows, or flood extents.

  13. Splitting statistical potentials into meaningful scoring functions: Testing the prediction of near-native structures from decoy conformations

    Directory of Open Access Journals (Sweden)

    Oliva Baldo

    2009-11-01

    Full Text Available Abstract Background Recent advances on high-throughput technologies have produced a vast amount of protein sequences, while the number of high-resolution structures has seen a limited increase. This has impelled the production of many strategies to built protein structures from its sequence, generating a considerable amount of alternative models. The selection of the closest model to the native conformation has thus become crucial for structure prediction. Several methods have been developed to score protein models by energies, knowledge-based potentials and combination of both. Results Here, we present and demonstrate a theory to split the knowledge-based potentials in scoring terms biologically meaningful and to combine them in new scores to predict near-native structures. Our strategy allows circumventing the problem of defining the reference state. In this approach we give the proof for a simple and linear application that can be further improved by optimizing the combination of Zscores. Using the simplest composite score ( we obtained predictions similar to state-of-the-art methods. Besides, our approach has the advantage of identifying the most relevant terms involved in the stability of the protein structure. Finally, we also use the composite Zscores to assess the conformation of models and to detect local errors. Conclusion We have introduced a method to split knowledge-based potentials and to solve the problem of defining a reference state. The new scores have detected near-native structures as accurately as state-of-art methods and have been successful to identify wrongly modeled regions of many near-native conformations.

  14. The Masculinity of Money: Automatic Stereotypes Predict Gender Differences in Estimated Salaries

    Science.gov (United States)

    Williams, Melissa J.; Paluck, Elizabeth Levy; Spencer-Rodgers, Julie

    2010-01-01

    We present the first empirical investigation of why men are assumed to earn higher salaries than women (the "salary estimation effect"). Although this phenomenon is typically attributed to conscious consideration of the national wage gap (i.e., real inequities in salary), we hypothesize instead that it reflects differential, automatic economic…

  15. Conformational B-Cell Epitopes Prediction from Sequences Using Cost-Sensitive Ensemble Classifiers and Spatial Clustering

    Directory of Open Access Journals (Sweden)

    Jian Zhang

    2014-01-01

    Full Text Available B-cell epitopes are regions of the antigen surface which can be recognized by certain antibodies and elicit the immune response. Identification of epitopes for a given antigen chain finds vital applications in vaccine and drug research. Experimental prediction of B-cell epitopes is time-consuming and resource intensive, which may benefit from the computational approaches to identify B-cell epitopes. In this paper, a novel cost-sensitive ensemble algorithm is proposed for predicting the antigenic determinant residues and then a spatial clustering algorithm is adopted to identify the potential epitopes. Firstly, we explore various discriminative features from primary sequences. Secondly, cost-sensitive ensemble scheme is introduced to deal with imbalanced learning problem. Thirdly, we adopt spatial algorithm to tell which residues may potentially form the epitopes. Based on the strategies mentioned above, a new predictor, called CBEP (conformational B-cell epitopes prediction, is proposed in this study. CBEP achieves good prediction performance with the mean AUC scores (AUCs of 0.721 and 0.703 on two benchmark datasets (bound and unbound using the leave-one-out cross-validation (LOOCV. When compared with previous prediction tools, CBEP produces higher sensitivity and comparable specificity values. A web server named CBEP which implements the proposed method is available for academic use.

  16. Conformational B-cell epitopes prediction from sequences using cost-sensitive ensemble classifiers and spatial clustering.

    Science.gov (United States)

    Zhang, Jian; Zhao, Xiaowei; Sun, Pingping; Gao, Bo; Ma, Zhiqiang

    2014-01-01

    B-cell epitopes are regions of the antigen surface which can be recognized by certain antibodies and elicit the immune response. Identification of epitopes for a given antigen chain finds vital applications in vaccine and drug research. Experimental prediction of B-cell epitopes is time-consuming and resource intensive, which may benefit from the computational approaches to identify B-cell epitopes. In this paper, a novel cost-sensitive ensemble algorithm is proposed for predicting the antigenic determinant residues and then a spatial clustering algorithm is adopted to identify the potential epitopes. Firstly, we explore various discriminative features from primary sequences. Secondly, cost-sensitive ensemble scheme is introduced to deal with imbalanced learning problem. Thirdly, we adopt spatial algorithm to tell which residues may potentially form the epitopes. Based on the strategies mentioned above, a new predictor, called CBEP (conformational B-cell epitopes prediction), is proposed in this study. CBEP achieves good prediction performance with the mean AUC scores (AUCs) of 0.721 and 0.703 on two benchmark datasets (bound and unbound) using the leave-one-out cross-validation (LOOCV). When compared with previous prediction tools, CBEP produces higher sensitivity and comparable specificity values. A web server named CBEP which implements the proposed method is available for academic use. PMID:25045691

  17. Does ecosystem sensitivity to precipitation at the site-level conform to regional-scale predictions?.

    Science.gov (United States)

    Wilcox, Kevin R; Blair, John M; Smith, Melinda D; Knapp, Alan K

    2016-03-01

    Central to understanding global C cycle dynamics is the functional relationship between precipitation and net primary production (NPP). At large spatial (regional) scales, the responsiveness of aboveground NPP (ANPP) to interannual variation in annual precipitation (AP; ANPPsens) is inversely related to site-level ANPP, coinciding with turnover of plant communities along precipitation gradients. Within ecosystems experiencing chronic alterations in water availability, plant community change will also occur with unknown consequences for ANPPsens. To examine the role plant community shifts may play in determining alterations in site-level ANPPPsens, we experimentally increased precipitation by approximately 35% for two decades in a native Central U.S. grassland. Consistent with regional models, ANPPsens decreased initially as water availability and ANPP increased. However, ANPPsens shifted back to ambient levels when mesic species increased in abundance in the plant community. Similarly, in grassland sites with distinct mesic and xeric plant communities and corresponding 50% differences in ANPP, ANPPsens did not differ over almost three decades. We conclude that responses in ANPPsens to chronic alterations in water availability within an ecosystem may not conform to regional AP-ANPP patterns, despite expected changes in ANPP and plant communities. The result is unanticipated functional resistance to climate change at the site scale. PMID:27197383

  18. Towards parsimony in habit measurement: Testing the convergent and predictive validity of an automaticity subscale of the Self-Report Habit Index

    Directory of Open Access Journals (Sweden)

    Gardner Benjamin

    2012-08-01

    Full Text Available Abstract Background The twelve-item Self-Report Habit Index (SRHI is the most popular measure of energy-balance related habits. This measure characterises habit by automatic activation, behavioural frequency, and relevance to self-identity. Previous empirical research suggests that the SRHI may be abbreviated with no losses in reliability or predictive utility. Drawing on recent theorising suggesting that automaticity is the ‘active ingredient’ of habit-behaviour relationships, we tested whether an automaticity-specific SRHI subscale could capture habit-based behaviour patterns in self-report data. Methods A content validity task was undertaken to identify a subset of automaticity indicators within the SRHI. The reliability, convergent validity and predictive validity of the automaticity item subset was subsequently tested in secondary analyses of all previous SRHI applications, identified via systematic review, and in primary analyses of four raw datasets relating to energy‐balance relevant behaviours (inactive travel, active travel, snacking, and alcohol consumption. Results A four-item automaticity subscale (the ‘Self-Report Behavioural Automaticity Index’; ‘SRBAI’ was found to be reliable and sensitive to two hypothesised effects of habit on behaviour: a habit-behaviour correlation, and a moderating effect of habit on the intention-behaviour relationship. Conclusion The SRBAI offers a parsimonious measure that adequately captures habitual behaviour patterns. The SRBAI may be of particular utility in predicting future behaviour and in studies tracking habit formation or disruption.

  19. Automatic machine learning based prediction of cardiovascular events in lung cancer screening data

    Science.gov (United States)

    de Vos, Bob D.; de Jong, Pim A.; Wolterink, Jelmer M.; Vliegenthart, Rozemarijn; Wielingen, Geoffrey V. F.; Viergever, Max A.; Išgum, Ivana

    2015-03-01

    Calcium burden determined in CT images acquired in lung cancer screening is a strong predictor of cardiovascular events (CVEs). This study investigated whether subjects undergoing such screening who are at risk of a CVE can be identified using automatic image analysis and subject characteristics. Moreover, the study examined whether these individuals can be identified using solely image information, or if a combination of image and subject data is needed. A set of 3559 male subjects undergoing Dutch-Belgian lung cancer screening trial was included. Low-dose non-ECG synchronized chest CT images acquired at baseline were analyzed (1834 scanned in the University Medical Center Groningen, 1725 in the University Medical Center Utrecht). Aortic and coronary calcifications were identified using previously developed automatic algorithms. A set of features describing number, volume and size distribution of the detected calcifications was computed. Age of the participants was extracted from image headers. Features describing participants' smoking status, smoking history and past CVEs were obtained. CVEs that occurred within three years after the imaging were used as outcome. Support vector machine classification was performed employing different feature sets using sets of only image features, or a combination of image and subject related characteristics. Classification based solely on the image features resulted in the area under the ROC curve (Az) of 0.69. A combination of image and subject features resulted in an Az of 0.71. The results demonstrate that subjects undergoing lung cancer screening who are at risk of CVE can be identified using automatic image analysis. Adding subject information slightly improved the performance.

  20. Automatically updating predictive modeling workflows support decision-making in drug design.

    Science.gov (United States)

    Muegge, Ingo; Bentzien, Jörg; Mukherjee, Prasenjit; Hughes, Robert O

    2016-09-01

    Using predictive models for early decision-making in drug discovery has become standard practice. We suggest that model building needs to be automated with minimum input and low technical maintenance requirements. Models perform best when tailored to answering specific compound optimization related questions. If qualitative answers are required, 2-bin classification models are preferred. Integrating predictive modeling results with structural information stimulates better decision making. For in silico models supporting rapid structure-activity relationship cycles the performance deteriorates within weeks. Frequent automated updates of predictive models ensure best predictions. Consensus between multiple modeling approaches increases the prediction confidence. Combining qualified and nonqualified data optimally uses all available information. Dose predictions provide a holistic alternative to multiple individual property predictions for reaching complex decisions.

  1. Prediction of the higher-order terms based on Borel resummation with conformal mapping

    CERN Document Server

    Kompaniets, M

    2016-01-01

    In this paper we discuss the method of the resummation of the asymptotic series suggested by Kazakov et al. (1978) and predictions of the higher order terms based on this approach. Application of this method to $\\varphi^4$ model is discussed.

  2. Predictive tools for severe dengue conforming to World Health Organization 2009 criteria.

    Directory of Open Access Journals (Sweden)

    Luis R Carrasco

    2014-07-01

    Full Text Available Dengue causes 50 million infections per year, posing a large disease and economic burden in tropical and subtropical regions. Only a proportion of dengue cases require hospitalization, and predictive tools to triage dengue patients at greater risk of complications may optimize usage of limited healthcare resources. For severe dengue (SD, proposed by the World Health Organization (WHO 2009 dengue guidelines, predictive tools are lacking.We undertook a retrospective study of adult dengue patients in Tan Tock Seng Hospital, Singapore, from 2006 to 2008. Demographic, clinical and laboratory variables at presentation from dengue polymerase chain reaction-positive and serology-positive patients were used to predict the development of SD after hospitalization using generalized linear models (GLMs.Predictive tools compatible with well-resourced and resource-limited settings--not requiring laboratory measurements--performed acceptably with optimism-corrected specificities of 29% and 27% respectively for 90% sensitivity. Higher risk of severe dengue (SD was associated with female gender, lower than normal hematocrit level, abdominal distension, vomiting and fever on admission. Lower risk of SD was associated with more years of age (in a cohort with an interquartile range of 27-47 years of age, leucopenia and fever duration on admission. Among the warning signs proposed by WHO 2009, we found support for abdominal pain or tenderness and vomiting as predictors of combined forms of SD.The application of these predictive tools in the clinical setting may reduce unnecessary admissions by 19% allowing the allocation of scarce public health resources to patients according to the severity of outcomes.

  3. Predicting free energy contributions to the conformational stability of folded proteins from the residue sequence with radial basis function networks

    Energy Technology Data Exchange (ETDEWEB)

    Casadio, R.; Fariselli, P.; Vivarelli, F. [Univ. of Bologna (Italy); Compiani, M. [Univ. of Camerino (Italy)

    1995-12-31

    Radial basis function neural networks are trained on a data base comprising 38 globular proteins of well resolved crystallographic structure and the corresponding free energy contributions to the overall protein stability (as computed partially from crystallographic analysis and partially with multiple regression from experimental thermodynamic data by Ponnuswamy and Gromiha (1994)). Starting from the residue sequence and using as input code the percentage of each residue and the total residue number of the protein, it is found with a cross-validation method that neural networks can optimally predict the free energy contributions due to hydrogen bonds, hydrophobic interactions and the unfolded state. Terms due to electrostatic and disulfide bonding free energies are poorly predicted. This is so also when other input codes, including the percentage of secondary structure type of the protein and/or residue-pair information are used. Furthermore, trained on the computed and/or experimental {Delta}G values of the data base, neural networks predict a conformational stability ranging from about 10 to 20 kcal mol{sup -1} rather independently of the residue sequence, with an average error per protein of about 9 kcal mol{sup -1}.

  4. Predicting free energy contributions to the conformational stability of folded proteins from the residue sequence with radial basis function networks.

    Science.gov (United States)

    Casadio, R; Compiani, M; Fariselli, P; Vivarelli, F

    1995-01-01

    Radial basis function neural networks are trained on a data base comprising 38 globular proteins of well resolved crystallographic structure and the corresponding free energy contributions to the overall protein stability (as computed partially from chrystallographic analysis and partially with multiple regression from experimental thermodynamic data by Ponnuswamy and Gromiha (1994)). Starting from the residue sequence and using as input code the percentage of each residue and the total residue number of the protein, it is found with a cross-validation method that neural networks can optimally predict the free energy contributions due to hydrogen bonds, hydrophobic interactions and the unfolded state. Terms due to electrostatic and disulfide bonding free energies are poorly predicted. This is so also when other input codes, including the percentage of secondary structure type of the protein and/or residue-pair information are used. Furthermore, trained on the computed and/or experimental delta G values of the data base, neural networks predict a conformational stability ranging from about 10 to 20 kcal mol-1 rather independently of the residue sequence, with an average error per protein of about 9 kcal mol-1.

  5. Automatic selection of reference taxa for protein-protein interaction prediction with phylogenetic profiling

    DEFF Research Database (Denmark)

    Simonsen, Martin; Maetschke, S.R.; Ragan, M.A.

    2012-01-01

    Motivation: Phylogenetic profiling methods can achieve good accuracy in predicting protein–protein interactions, especially in prokaryotes. Recent studies have shown that the choice of reference taxa (RT) is critical for accurate prediction, but with more than 2500 fully sequenced taxa publicly......: We present three novel methods for automating the selection of RT, using machine learning based on known protein–protein interaction networks. One of these methods in particular, Tree-Based Search, yields greatly improved prediction accuracies. We further show that different methods for constituting...... phylogenetic profiles often require very different RT sets to support high prediction accuracy....

  6. Improved predictive mapping of indoor radon concentrations using ensemble regression trees based on automatic clustering of geological units

    International Nuclear Information System (INIS)

    Purpose: According to estimations around 230 people die as a result of radon exposure in Switzerland. This public health concern makes reliable indoor radon prediction and mapping methods necessary in order to improve risk communication to the public. The aim of this study was to develop an automated method to classify lithological units according to their radon characteristics and to develop mapping and predictive tools in order to improve local radon prediction. Method: About 240 000 indoor radon concentration (IRC) measurements in about 150 000 buildings were available for our analysis. The automated classification of lithological units was based on k-medoids clustering via pair-wise Kolmogorov distances between IRC distributions of lithological units. For IRC mapping and prediction we used random forests and Bayesian additive regression trees (BART). Results: The automated classification groups lithological units well in terms of their IRC characteristics. Especially the IRC differences in metamorphic rocks like gneiss are well revealed by this method. The maps produced by random forests soundly represent the regional difference of IRCs in Switzerland and improve the spatial detail compared to existing approaches. We could explain 33% of the variations in IRC data with random forests. Additionally, the influence of a variable evaluated by random forests shows that building characteristics are less important predictors for IRCs than spatial/geological influences. BART could explain 29% of IRC variability and produced maps that indicate the prediction uncertainty. Conclusion: Ensemble regression trees are a powerful tool to model and understand the multidimensional influences on IRCs. Automatic clustering of lithological units complements this method by facilitating the interpretation of radon properties of rock types. This study provides an important element for radon risk communication. Future approaches should consider taking into account further variables

  7. Automatic selection of preprocessing methods for improving predictions on mass spectrometry protein profiles.

    Science.gov (United States)

    Pelikan, Richard C; Hauskrecht, Milos

    2010-11-13

    Mass spectrometry proteomic profiling has potential to be a useful clinical screening tool. One obstacle is providing a standardized method for preprocessing the noisy raw data. We have developed a system for automatically determining a set of preprocessing methods among several candidates. Our system's automated nature relieves the analyst of the need to be knowledgeable about which methods to use on any given dataset. Each stage of preprocessing is approached with many competing methods. We introduce metrics which are used to balance each method's attempts to correct noise versus preserving valuable discriminative information. We demonstrate the benefit of our preprocessing system on several SELDI and MALDI mass spectrometry datasets. Downstream classification is improved when using our system to preprocess the data.

  8. Automatic parametrization of implicit solvent models for the blind prediction of solvation free energies

    CERN Document Server

    Wang, Bao; Wei, Guowei

    2016-01-01

    In this work, a systematic protocol is proposed to automatically parametrize implicit solvent models with polar and nonpolar components. The proposed protocol utilizes the classical Poisson model or the Kohn-Sham density functional theory (KSDFT) based polarizable Poisson model for modeling polar solvation free energies. For the nonpolar component, either the standard model of surface area, molecular volume, and van der Waals interactions, or a model with atomic surface areas and molecular volume is employed. Based on the assumption that similar molecules have similar parametrizations, we develop scoring and ranking algorithms to classify solute molecules. Four sets of radius parameters are combined with four sets of charge force fields to arrive at a total of 16 different parametrizations for the Poisson model. A large database with 668 experimental data is utilized to validate the proposed protocol. The lowest leave-one-out root mean square (RMS) error for the database is 1.33k cal/mol. Additionally, five s...

  9. Automatic prediction of rheumatoid arthritis disease activity from the electronic medical records.

    Directory of Open Access Journals (Sweden)

    Chen Lin

    Full Text Available OBJECTIVE: We aimed to mine the data in the Electronic Medical Record to automatically discover patients' Rheumatoid Arthritis disease activity at discrete rheumatology clinic visits. We cast the problem as a document classification task where the feature space includes concepts from the clinical narrative and lab values as stored in the Electronic Medical Record. MATERIALS AND METHODS: The Training Set consisted of 2792 clinical notes and associated lab values. Test Set 1 included 1749 clinical notes and associated lab values. Test Set 2 included 344 clinical notes for which there were no associated lab values. The Apache clinical Text Analysis and Knowledge Extraction System was used to analyze the text and transform it into informative features to be combined with relevant lab values. RESULTS: Experiments over a range of machine learning algorithms and features were conducted. The best performing combination was linear kernel Support Vector Machines with Unified Medical Language System Concept Unique Identifier features with feature selection and lab values. The Area Under the Receiver Operating Characteristic Curve (AUC is 0.831 (σ = 0.0317, statistically significant as compared to two baselines (AUC = 0.758, σ = 0.0291. Algorithms demonstrated superior performance on cases clinically defined as extreme categories of disease activity (Remission and High compared to those defined as intermediate categories (Moderate and Low and included laboratory data on inflammatory markers. CONCLUSION: Automatic Rheumatoid Arthritis disease activity discovery from Electronic Medical Record data is a learnable task approximating human performance. As a result, this approach might have several research applications, such as the identification of patients for genome-wide pharmacogenetic studies that require large sample sizes with precise definitions of disease activity and response to therapies.

  10. Predicting side-chain conformations of methionine using a hard-sphere model with stereochemical constraints

    Science.gov (United States)

    Virrueta, A.; Gaines, J.; O'Hern, C. S.; Regan, L.

    2015-03-01

    Current research in the O'Hern and Regan laboratories focuses on the development of hard-sphere models with stereochemical constraints for protein structure prediction as an alternative to molecular dynamics methods that utilize knowledge-based corrections in their force-fields. Beginning with simple hydrophobic dipeptides like valine, leucine, and isoleucine, we have shown that our model is able to reproduce the side-chain dihedral angle distributions derived from sets of high-resolution protein crystal structures. However, methionine remains an exception - our model yields a chi-3 side-chain dihedral angle distribution that is relatively uniform from 60 to 300 degrees, while the observed distribution displays peaks at 60, 180, and 300 degrees. Our goal is to resolve this discrepancy by considering clashes with neighboring residues, and averaging the reduced distribution of allowable methionine structures taken from a set of crystallized proteins. We will also re-evaluate the electron density maps from which these protein structures are derived to ensure that the methionines and their local environments are correctly modeled. This work will ultimately serve as a tool for computing side-chain entropy and protein stability. A. V. is supported by an NSF Graduate Research Fellowship and a Ford Foundation Fellowship. J. G. is supported by NIH training Grant NIH-5T15LM007056-28.

  11. Automatic Artefact Removal and CO2 Prediction from the EEG Signals of Preterm Babies

    OpenAIRE

    Buriro, Abdul Baseer

    2014-01-01

    This dissertation describes research whose the purpose is to remove artefacts from the EEG signals of preterm neonates, thereby facilitating the prediction of carbon dioxide levels dissolved in the blood; this was achieved using key statistics obtained from the EEG. The EEG signals of neonates were recorded over a 24 – 36 hours period using LabVIEW (National Instruments) software and a XLTEK EMU40EX breakout head box with a 7- electrodes configuration. Raw EEG signals of neonates were process...

  12. Measuring Peer Pressure, Popularity, and Conformity in Adolescent Boys and Girls: Predicting School Performance, Sexual Attitudes, and Substance Abuse.

    Science.gov (United States)

    Santor, Darcy A.; Messervey, Deanna; Kusumakar, Vivek

    2000-01-01

    Developed and validated short measures of peer pressure, peer conformity, and popularity with 148 adolescent Canadian boys and girls in grades 11 to 13. Results show all constructed measures to be internally consistent. Peer pressure and peer conformity were stronger predictors of risk behavior than measures assessing popularity, general…

  13. Predicting new-onset of postoperative atrial fibrillation in patients undergoing cardiac surgery using semi-automatic reading of perioperative electrocardiograms

    DEFF Research Database (Denmark)

    Gu, Jiwei; Graff, Claus; Melgaard, Jacob;

    2015-01-01

    P10 Predicting new-onset of postoperative atrial fibrillation in patients undergoingcardiac surgery using semi-automatic reading of perioperative electrocardiograms. Jiwei Gu, Claus Graff, Jacob Melgaard, Søren Lundbye-Christensen, Erik Berg Schmidt, Christian Torp-Pedersen, Kristinn Thorsteinsson......, Jan Jesper Andreasen. Aalborg, DenmarkBackground: Postoperative new onset atrial fibrillation (POAF) is the most common arrhythmia after cardiac surgery. The aim of this study was to evaluate if semi-automatic readings of perioperative electrocardiograms (ECGs) is of any value in predicting POAF after...... ECG monitoring. A semi-automatic machine capable of reading differentparameters of digitalized ECG’s was used to read both lead specific (P/QRS/T amplitudes/intervals) and global measurements (P-duration/QRS-duration/PR-interval/QT/Heart Rate/hypertrophy).Results: We divided the patients into two...

  14. Towards an automatic statistical model for seasonal precipitation prediction and its application to Central and South Asian headwater catchments

    Science.gov (United States)

    Gerlitz, Lars; Gafurov, Abror; Apel, Heiko; Unger-Sayesteh, Katy; Vorogushyn, Sergiy; Merz, Bruno

    2016-04-01

    Statistical climate forecast applications typically utilize a small set of large scale SST or climate indices, such as ENSO, PDO or AMO as predictor variables. If the predictive skill of these large scale modes is insufficient, specific predictor variables such as customized SST patterns are frequently included. Hence statistically based climate forecast models are either based on a fixed number of climate indices (and thus might not consider important predictor variables) or are highly site specific and barely transferable to other regions. With the aim of developing an operational seasonal forecast model, which is easily transferable to any region in the world, we present a generic data mining approach which automatically selects potential predictors from gridded SST observations and reanalysis derived large scale atmospheric circulation patterns and generates robust statistical relationships with posterior precipitation anomalies for user selected target regions. Potential predictor variables are derived by means of a cellwise correlation analysis of precipitation anomalies with gridded global climate variables under consideration of varying lead times. Significantly correlated grid cells are subsequently aggregated to predictor regions by means of a variability based cluster analysis. Finally for every month and lead time, an individual random forest based forecast model is automatically calibrated and evaluated by means of the preliminary generated predictor variables. The model is exemplarily applied and evaluated for selected headwater catchments in Central and South Asia. Particularly the for winter and spring precipitation (which is associated with westerly disturbances in the entire target domain) the model shows solid results with correlation coefficients up to 0.7, although the variability of precipitation rates is highly underestimated. Likewise for the monsoonal precipitation amounts in the South Asian target areas a certain skill of the model could

  15. Field theoretical Lie symmetry analysis: The Möbius group, exact solutions of conformal autonomous systems, and predictive model-building

    Science.gov (United States)

    Christodoulides, Kyriakos

    2014-07-01

    We study single and coupled first-order differential equations (ODEs) that admit symmetries with tangent vector fields, which satisfy the N-dimensional Cauchy-Riemann equations. In the two-dimensional case, classes of first-order ODEs which are invariant under Möbius transformations are explored. In the N dimensional case we outline a symmetry analysis method for constructing exact solutions for conformal autonomous systems. A very important aspect of this work is that we propose to extend the traditional technical usage of Lie groups to one that could provide testable predictions and guidelines for model-building and model-validation. The Lie symmetries in this paper are constrained and classified by field theoretical considerations and their phenomenological implications. Our results indicate that conformal transformations are appropriate for elucidating a variety of linear and nonlinear systems which could be used for, or inspire, future applications. The presentation is pragmatic and it is addressed to a wide audience.

  16. Applications of neural network prediction of conformational states for small peptides from spectra and of fold classes

    DEFF Research Database (Denmark)

    Bohr, Henrik; Røgen, Peter; Jalkanen, Karl J.

    2001-01-01

    Electronic structures of small peptides were calculated 'ab initio' with the help of Density Functional Theory (DFT) and molecular dynamics that rendered a set of conformational states of the peptides. For the structures of these states it was possible to derive atomic polar tensors that allowed us...... to construct vibrational spectra for each of the conformational states with low energy. From the spectra, neural networks could be trained to distinguish between the various states and thus be able to generate a larger set of relevant structures and their relation to secondary structures of the peptides....... The calculations were done both with solvent atoms (up to ten water molecules) and without, and hence the neural networks could be used to monitor the influence of the solvent on hydrogen bond formation. The calculations at this stage only involved very short peptide fragments of a few alanine amino acids...

  17. Benford's law predicted digit distribution of aggregated income taxes: the surprising conformity of Italian cities and regions

    Science.gov (United States)

    Mir, Tariq Ahmad; Ausloos, Marcel; Cerqueti, Roy

    2014-11-01

    The yearly aggregated tax income data of all, more than 8000, Italian municipalities are analyzed for a period of five years, from 2007 to 2011, to search for conformity or not with Benford's law, a counter-intuitive phenomenon observed in large tabulated data where the occurrence of numbers having smaller initial digits is more favored than those with larger digits. This is done in anticipation that large deviations from Benford's law will be found in view of tax evasion supposedly being widespread across Italy. Contrary to expectations, we show that the overall tax income data for all these years is in excellent agreement with Benford's law. Furthermore, we also analyze the data of Calabria, Campania and Sicily, the three Italian regions known for strong presence of mafia, to see if there are any marked deviations from Benford's law. Again, we find that all yearly data sets for Calabria and Sicily agree with Benford's law whereas only the 2007 and 2008 yearly data show departures from the law for Campania. These results are again surprising in view of underground and illegal nature of economic activities of mafia which significantly contribute to tax evasion. Some hypothesis for the found conformity is presented.

  18. Delineating the conformal window

    DEFF Research Database (Denmark)

    Frandsen, Mads Toudal; Pickup, Thomas; Teper, Michael

    2011-01-01

    We identify and characterise the conformal window in gauge theories relevant for beyond the standard model building, e.g. Technicolour, using the criteria of metric confinement and causal analytic couplings, which are known to be consistent with the phase diagram of supersymmetric QCD from Seiberg...... duality. Using these criteria we find perturbation theory to be consistent throughout the predicted conformal window for several of these gauge theories and we discuss recent lattice results in the light of our findings....

  19. Benford's law predicted digit distribution of aggregated income taxes: the surprising conformity of Italian cities and regions

    CERN Document Server

    Mir, Tariq Ahmad; Cerqueti, Roy

    2014-01-01

    The yearly aggregated tax income data of all, more than 8000, Italian municipalities are analyzed for a period of five years, from 2007 to 2011, to search for conformity or not with Benford's law, a counter-intuitive phenomenon observed in large tabulated data where the occurrence of numbers having smaller initial digits is more favored than those with larger digits. This is done in anticipation that large deviations from Benford's law will be found in view of tax evasion supposedly being widespread across Italy. Contrary to expectations, we show that the overall tax income data for all these years is in excellent agreement with Benford's law. Furthermore, we also analyze the data of Calabria, Campania and Sicily, the three Italian regions known for strong presence of mafia, to see if there are any marked deviations from Benford's law. Again, we find that all yearly data sets for Calabria and Sicily agree with Benford's law whereas only the 2007 and 2008 yearly data show departures from the law for Campania. ...

  20. Workers’ Conformism

    Directory of Open Access Journals (Sweden)

    Nikolay Ivantchev

    2013-10-01

    Full Text Available Conformism was studied among 46 workers with different kinds of occupations by means of two modified scales measuring conformity by Santor, Messervey, and Kusumakar (2000 – scale for perceived peer pressure and scale for conformism in antisocial situations. The hypothesis of the study that workers’ conformism is expressed in a medium degree was confirmed partly. More than a half of the workers conform in a medium degree for taking risk, and for the use of alcohol and drugs, and for sexual relationships. More than a half of the respondents conform in a small degree for anti-social activities (like a theft. The workers were more inclined to conform for risk taking (10.9%, then – for the use of alcohol, drugs and for sexual relationships (8.7%, and in the lowest degree – for anti-social activities (6.5%. The workers who were inclined for the use of alcohol and drugs tended also to conform for anti-social activities.

  1. Automatic sequences

    CERN Document Server

    Haeseler, Friedrich

    2003-01-01

    Automatic sequences are sequences which are produced by a finite automaton. Although they are not random they may look as being random. They are complicated, in the sense of not being not ultimately periodic, they may look rather complicated, in the sense that it may not be easy to name the rule by which the sequence is generated, however there exists a rule which generates the sequence. The concept automatic sequences has special applications in algebra, number theory, finite automata and formal languages, combinatorics on words. The text deals with different aspects of automatic sequences, in particular:· a general introduction to automatic sequences· the basic (combinatorial) properties of automatic sequences· the algebraic approach to automatic sequences· geometric objects related to automatic sequences.

  2. Conformal Infinity

    Directory of Open Access Journals (Sweden)

    Frauendiener Jörg

    2000-08-01

    Full Text Available The notion of conformal infinity has a long history within the research in Einstein's theory of gravity. Today, ``conformal infinity'' is related with almost all other branches of research in general relativity, from quantisation procedures to abstract mathematical issues to numerical applications. This review article attempts to show how this concept gradually and inevitably evolved out of physical issues, namely the need to understand gravitational radiation and isolated systems within the theory of gravitation and how it lends itself very naturally to solve radiation problems in numerical relativity. The fundamental concept of null-infinity is introduced. Friedrich's regular conformal field equations are presented and various initial value problems for them are discussed. Finally, it is shown that the conformal field equations provide a very powerful method within numerical relativity to study global problems such as gravitational wave propagation and detection.

  3. Conformal Infinity

    Directory of Open Access Journals (Sweden)

    Frauendiener Jörg

    2004-01-01

    Full Text Available The notion of conformal infinity has a long history within the research in Einstein's theory of gravity. Today, 'conformal infinity' is related to almost all other branches of research in general relativity, from quantisation procedures to abstract mathematical issues to numerical applications. This review article attempts to show how this concept gradually and inevitably evolved from physical issues, namely the need to understand gravitational radiation and isolated systems within the theory of gravitation, and how it lends itself very naturally to the solution of radiation problems in numerical relativity. The fundamental concept of null-infinity is introduced. Friedrich's regular conformal field equations are presented and various initial value problems for them are discussed. Finally, it is shown that the conformal field equations provide a very powerful method within numerical relativity to study global problems such as gravitational wave propagation and detection.

  4. Predictions for the Top-Quark Forward-Backward Asymmetry at High Invariant Pair Mass Using the Principle of Maximum Conformality

    CERN Document Server

    Wang, Sheng-Quan; Si, Zong-Guo; Brodsky, Stanley J

    2016-01-01

    The D0 collaboration at FermiLab has recently measured the top-quark pair forward-backward asymmetry in $\\bar p p \\to t \\bar t X$ reactions as a function of the $\\bar t t $ invariant mass $M_{t\\bar{t}}$. D0 observed that the asymmetry $A_{\\rm FB}(M_{t\\bar{t}})$ first increases and then decreases as $M_{t\\bar{t}}$ is increased. This behavior is not explained using conventional renormalization scale-setting, even by a next-to-next-to-leading order (N$^2$LO) QCD calculation -- one predicts a monotonically increasing behavior. In the conventional scale-setting method, one simply guesses a single renormalization scale $\\mu_r$ for the argument of the QCD running coupling and then varies it over an arbitrary range. However, the conventional method has inherent difficulties. ...... In contrast, if one fixes the scale using the Principle of Maximum Conformality (PMC), the resulting pQCD predictions are renormalization-scheme independent since all of the scheme-dependent $\\{\\beta_i\\}$-terms in the QCD perturbative seri...

  5. 基于 BP 神经网络的调剖效果预测模型分析%Prediction model of conformance control effect based on BP neural network

    Institute of Scientific and Technical Information of China (English)

    刘宁; 刘士梦; 李明

    2014-01-01

    产油量预测是调剖方案实施以后效果预测或评价的关键,基于BP神经网络理论,通过分析影响调剖效果的因素,利用Matlab神经网络工具箱函数,建立了调剖神经网络预测模型,经过模型预测效果分析及实际运用,认为利用BP神经网络预测产油量与实际值较为吻合,误差相对较小,可靠性高,可运用此模型预测调剖产油量。%The oil production prediction is a key to prediction or evaluation of conformance control effect after the scheme implementation .Based on the theory of BP neural network ,by analyzing the influencing factors of conformance con-trol effect ,the neural network prediction model for conformance control was established by employing the toolbox functions in the Matlab neural network .Through the analysis of the model forecast effect and practical application ,it was considered that the oil production predicted by the BP neural network was consistent with the actual one ,which had smaller relative error and high reliable .The model can be used to predict the conformance control production .

  6. The Role of Phonological Awareness and Rapid Automatized Naming in the Prediction of Reading Difficulties in Portuguese

    Directory of Open Access Journals (Sweden)

    Mirelle F. Michalick-Triginelli

    2015-12-01

    Full Text Available AbstractThis study investigated the contribution of phonological awareness (PA and rapid automatized naming (RAN to the persistence of beginning reading difficulties in Portuguese. The study was longitudinal and involved 13 children who had shown little progress in learning to read during their 1st school year, and 13 children with typical reading development. At the beginning of the study, when participants were, on average, six years and nine months of age, their ability to read and spell words, and their PA and RAN skills were assessed. One year later, the children who had shown difficulties in learning to read were divided into two groups, based on their progress in learning to read during the course of the study: a group with persistent reading difficulties and a group whose difficulties had been overcome. Results showed that both groups performed equally poorly and below controls on the PA tasks at the beginning of the study. In contrast, only the children with persistent reading difficulties performed more poorly than controls on the RAN tasks at that time.

  7. H/L transition time estimation in JET using conformal predictors

    Energy Technology Data Exchange (ETDEWEB)

    Gonzalez, S., E-mail: sergio.gonzalez@ciemat.es [Asociacion EURATOM/CIEMAT para Fusion, Madrid 28040 (Spain); Vega, J. [Asociacion EURATOM/CIEMAT para Fusion, Madrid 28040 (Spain); Murari, A. [Consorzio RFX, Associazione EURATOM/ENEA per la Fusione, Padova 4-25127 (Italy); Pereira, A. [Asociacion EURATOM/CIEMAT para Fusion, Madrid 28040 (Spain); Dormido-Canto, S.; Ramirez, J.M. [Departamento de Informatica y Automatica, UNED, Madrid 28040 (Spain)

    2012-12-15

    Highlights: Black-Right-Pointing-Pointer H/L transitions have been predicted using H/L and L/H models. Black-Right-Pointing-Pointer Models have been built using conformal predictors to hedge the prediction with confidence and credibility measures. Black-Right-Pointing-Pointer Models have been trained using linear and radial basis function kernels. Black-Right-Pointing-Pointer Conformal measures have proven their usefulness to validate data-driven models. - Abstract: Recent advances in data mining allow the automatic recognition of physical phenomena in the databases of fusion devices without human intervention. This is important to create large databases of physical events (thereby increasing the statistical relevance) in an unattended manner. Important examples are the L/H and H/L transitions. In this contribution, a novel technique is introduced to automatically locate H/L transitions in JET by using conformal predictors. The focus is on H/L transitions because typically there is not a clear signature in the time series of the most widely available signals to recognize the change of confinement. Conformal predictors hedge their prediction by means of two parameters: confidence and credibility. The technique has been based on binary supervised classifiers to separate the samples of the respective confinement modes. Results with several underlying classifiers are presented.

  8. Study on automatic prediction of sentential stress for Chinese Putonghua Text-to-Speech system with natural style

    Institute of Scientific and Technical Information of China (English)

    SHAO Yanqiu; HAN Jiqing; ZHAO Yongzhen; LIU Ting

    2007-01-01

    Stress is an important parameter for prosody processing in speech synthesis. In this paper, we compare the acoustic features of neutral tone syllables and strong stress syllables with moderate stress syllables, including pitch, syllable duration, intensity and pause length after syllable. The relation between duration and pitch, as well as the Third Tone (T3) and pitch are also studied. Three stress prediction models based on ANN, i.e. the acoustic model,the linguistic model and the mixed model, are presented for predicting Chinese sentential stress.The results show that the mixed model performs better than the other two models. In order to solve the problem of the diversity of manual labeling, an evaluation index of support ratio is proposed.

  9. An experimental study of visual flight trajectory tracking and pose prediction for the automatic computer control of a miniature airship

    Science.gov (United States)

    Haecker, Jens; Kroeplin, Bernd H.

    2003-08-01

    This paper describes our current work in developing a vision-based tracking and trajectory prediction system for an aerial robot based on low-cost digital cameras, image processing techniques, and a filtering and prediction algorithm. The system determines the pose (location and orientation) of a miniature airship, online during indoor flight, and will be used in a development framework for a future autonomous flight control system. Object localization is achieved by tracking an infra-red target array mounted to a model airship. Its pose in three-dimensional space can be computed from corresponding points in the images of two cameras which are calibrated in a global coordinate system. The calibration procedure and the localization, as well as some aspects of the measurement accuracy achieved, are discussed. Real-world applications provide an uncertain static or dynamic environment which complicates the tracking of a target. To overcome problems due to noisy data or even failed target detection in image frames, a filtering procedure is applied for estimating the airship's pose. In a first step, points in the two-dimensional image planes are directly tracked and propagated forward to the vehicle pose. In a second step, an adaptive noise Kalman filter is applied for estimating and predicting the flight trajectory. Its state is propagated back to points in the image planes to guide the detection algorithm by defining regions of confidence. Both approaches are combined in a tracking algorithm. In-flight measurements are used to validate the parameters of the adaption procedure. Some experimental results are shown.

  10. Analysis of dose-volume parameters predicting radiation pneumonitis in patients with esophageal cancer treated with 3D-conformal radiation therapy or IMRT

    International Nuclear Information System (INIS)

    Multimodality therapy for esophageal cancer can cause various kinds of treatment-related sequelae, especially pulmonary toxicities. This prospective study aims to investigate the clinical and dosimetric parameters predicting lung injury in patients undergoing radiation therapy for esophageal cancer. Forty-five esophageal cancer patients were prospectively analyzed. The pulmonary toxicities (or sequelae) were evaluated by comparing chest X-ray films, pulmonary function tests and symptoms caused by pulmonary damage before and after treatment. All patients were treated with either three-dimensional radiotherapy (3DCRT) or with intensity-modulated radiotherapy (IMRT). The planning dose volume histogram was used to compute the lung volumes receiving more than 5, 10, 20 and 30 Gy (V5, V10, V20, V30) and mean lung dose. V20 was larger in the IMRT group than in the 3DCRT group (p=0.002). V20 (>15%) and V30 (>20%) resulted in a statistically significant increase in the occurrence of chronic pneumonitis (p=0.03) and acute pneumonitis (p=0.007), respectively. The study signifies that a larger volume of lung receives lower doses because of multiple beam arrangement and a smaller volume of lung receives higher doses because of better dose conformity in IMRT plans. Acute pneumonitis correlates more with V30 values, whereas chronic pneumonitis was predominantly seen in patients with higher V20 values. (author)

  11. Hot Conformal Gauge Theories

    DEFF Research Database (Denmark)

    Mojaza, Matin; Pica, Claudio; Sannino, Francesco

    2010-01-01

    We compute the nonzero temperature free energy up to the order g^6 \\ln(1/g) in the coupling constant for vector like SU(N) gauge theories featuring matter transforming according to different representations of the underlying gauge group. The number of matter fields, i.e. flavors, is arranged...... in such a way that the theory develops a perturbative stable infrared fixed point at zero temperature. Due to large distance conformality we trade the coupling constant with its fixed point value and define a reduced free energy which depends only on the number of flavors, colors and matter representation. We...... of flavors. Surprisingly this number, if computed to the order g^2, agrees with previous predictions for the lower boundary of the conformal window for nonsupersymmetric gauge theories. The higher order results tend to predict a higher number of critical flavors. These are universal properties, i...

  12. Automatic voltage regulation of synchronous generator using generalized predictive control; Ippanka yosoku seigyo wo mochiita doki hatsudenki no jido den`atsu chosei

    Energy Technology Data Exchange (ETDEWEB)

    Funabiki, S.; Yamakawa, S. [Okayama University, Okayama (Japan). Faculty of Engineering; Ito, T. [Nishishiba Electric Co. Ltd., Hyogo (Japan)

    1995-02-28

    For the automatic voltage regulator (AVR) of a synchronous generator, various applications of self-tuning digital control (STC) have been experimented which successively adjusts PID gains to cope with dynamic characteristics such as disturbances of a plant. As one of such applications, a proposal has been made in this paper for a stable and highly adaptable control system by using a generalized predictive control as the control law and the sequential least-square method as the identification method. An experiment was carried out by a simulation and an experimental AVR, and the effectiveness was confirmed of this control method. The following points may be listed in summarizing the characteristics of this AVR. The arithmetic time is short, and a highly accurate identification value is obtainable. Since an oblivion coefficient is determined by the supremum trace gain method, the adaptability is increased on the parameter identification value. A stable control is obtained even if a plant is a non-minimum phase system. 10 refs., 11 figs., 2 tabs.

  13. Conformal polishing approach: Tool footprint analysis

    Directory of Open Access Journals (Sweden)

    José A Dieste

    2016-02-01

    Full Text Available Polishing process is one of the most critical manufacturing processes during a metal part production because it determines the final quality of the product. Free-form surface polishing is a handmade process with lots of rejected parts, scrap generation and time and energy consumption. Two different research lines are being developed: prediction models of the final surface quality parameters and an analysis of the amount of material removed depending on the polishing parameters to predict the tool footprint during the polishing task. This research lays the foundations for a future automatic conformal polishing system. It is based on rotational and translational tool with dry abrasive in the front mounted at the end of a robot. A tool to part concept is used, useful for large or heavy workpieces. Results are applied on different curved parts typically used in tooling industry, aeronautics or automotive. A mathematical model has been developed to predict the amount of material removed in function of polishing parameters. Model has been fitted for different abrasives and raw materials. Results have shown deviations under 20% that implies a reliable and controllable process. Smaller amount of material can be removed in controlled areas of a three-dimensional workpiece.

  14. Conformal covariance and the split property

    CERN Document Server

    Morinelli, Vincenzo; Weiner, Mihály

    2016-01-01

    We show that for a conformal local net of observables on the circle, the split property is automatic. Both full conformal covariance (i.e. diffeomorphism covariance) and the circle-setting play essential roles in this fact, while by previously constructed examples it was already known that even on the circle, M\\"obius covariance does not imply the split property. On the other hand, here we also provide an example of a local conformal net living on the two-dimensional Minkowski space, which - although being diffeomorphism covariant - does not have the split property.

  15. Automatic Reading

    Institute of Scientific and Technical Information of China (English)

    胡迪

    2007-01-01

    <正>Reading is the key to school success and,like any skill,it takes practice.A child learns to walk by practising until he no longer has to think about how to put one foot in front of the other.The great athlete practises until he can play quickly,accurately and without thinking.Ed- ucators call it automaticity.

  16. Non-conformable, partial and conformable transposition

    DEFF Research Database (Denmark)

    König, Thomas; Mäder, Lars Kai

    2013-01-01

    Although member states are obliged to transpose directives into domestic law in a conformable manner and receive considerable time for their transposition activities, we identify three levels of transposition outcomes for EU directives: conformable, partially conformable and non-conformable...... and the Commission regarding a directive’s outcome, play a much more strategic role than has to date acknowledged in the transposition literature. Whereas disagreement of a member state delays conformable transposition, it speeds up non-conformable transposition. Disagreement of the Commission only prolongs...

  17. Conformal transformations and conformal invariance in gravitation

    CERN Document Server

    Dabrowski, Mariusz P; Blaschke, David B

    2008-01-01

    Conformal transformations are frequently used tools in order to study relations between various theories of gravity and Einstein relativity. Because of that, in this paper we discuss the rules of conformal transformations for geometric quantities in general relativity. In particular, we discuss the conformal transformations of the matter energy-momentum tensor. We thoroughly discuss the latter and show the subtlety of the conservation law (i.e., the geometrical Bianchi identity) imposed in one of the conformal frames in reference to the other. The subtlety refers to the fact that conformal transformation ``creates'' an extra matter term composed of the conformal factor which enters the conservation law. In an extreme case of the flat original spacetime the matter is ``created'' due to work done by the conformal transformation to bend the spacetime which was originally flat. We also discuss how to construct the conformally invariant gravity which, in the simplest version, is a special case of the Brans-Dicke t...

  18. Leaf growth is conformal

    Science.gov (United States)

    Alim, Karen; Armon, Shahaf; Shraiman, Boris I.; Boudaoud, Arezki

    2016-10-01

    Growth pattern dynamics lie at the heart of morphogenesis. Here, we investigate the growth of plant leaves. We compute the conformal transformation that maps the contour of a leaf at a given stage onto the contour of the same leaf at a later stage. Based on the mapping we predict the local displacement field in the leaf blade and find it to agree with the experimentally measured displacement field to 92%. This approach is applicable to any two-dimensional system with locally isotropic growth, enabling the deduction of the whole growth field just from observation of the tissue contour.

  19. Conformal isoparametric hypersurfaces with two distinct conformal principal curvatures in conformal space

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    The conformal geometry of regular hypersurfaces in the conformal space is studied.We classify all the conformal isoparametric hypersurfaces with two distinct conformal principal curvatures in the conformal space up to conformal equivalence.

  20. Neuroanatomical automatic segmentation in brain cancer patients

    OpenAIRE

    D’Haese, P.; Niermann, K; Cmelak, A.; Donnelly, E.; Duay, V.; Li, R; Dawant, B.

    2003-01-01

    Conformally prescribed radiation therapy for brain cancer requires precisely defining the target treatment area, as well as delineating vital brain structures which must be spared from radiotoxicity. The current clinical practice of manually segmenting brain structures can be complex and exceedingly time consuming. Automatic computeraided segmentation methods have been proposed to increase efficiency and reproducibility in developing radiation treatment plans. Previous studies have establishe...

  1. Making the Case for Conformal Gravity

    CERN Document Server

    Mannheim, Philip D

    2011-01-01

    We review some recent developments in the conformal gravity theory that has been advanced as a candidate alternative to standard Einstein gravity. As a quantum theory the conformal theory is both renormalizable and unitary, with unitarity being obtained because the theory is a $PT$ symmetric rather than a Hermitian theory. We show that in the theory there can be no a priori classical curvature, with all curvature having to result from quantization. In the conformal theory gravity requires no independent quantization of its own, with it being quantized solely by virtue of its being coupled to a quantized matter source. Moreover, because it is this very coupling that fixes the strength of the gravitational field commutators, the gravity sector zero-point energy density and pressure fluctuations are then able to identically cancel the zero-point fluctuations associated with the matter sector. In addition, we show that when the conformal symmetry is spontaneously broken, the zero-point structure automatically rea...

  2. 40 CFR 91.511 - Suspension and revocation of certificates of conformity.

    Science.gov (United States)

    2010-07-01

    ... certificates of conformity. 91.511 Section 91.511 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Production Line Testing Program § 91.511 Suspension and revocation of certificates of conformity. (a) The certificate of conformity is automatically suspended with respect to any engine failing pursuant to...

  3. 40 CFR 1033.340 - Suspension and revocation of certificates of conformity.

    Science.gov (United States)

    2010-07-01

    ... certificates of conformity. 1033.340 Section 1033.340 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Production Line Testing and Audit Programs § 1033.340 Suspension and revocation of certificates of conformity... conformity is automatically suspended for any locomotive that fails a production line test pursuant to §...

  4. Conformal Gravity Rotation Curves with a Conformal Higgs Halo

    CERN Document Server

    Horne, Keith

    2016-01-01

    We discuss the effect of a conformally coupled Higgs field on conformal gravity (CG) predictions for the rotation curves of galaxies. The Mannheim-Kazanas (MK) metric is a valid vacuum solution of CG's 4-th order Poisson equation only if the Higgs field has a particular radial profile, S(r)=S_0 a/(r+a), decreasing from S_0 at r=0 with radial scale length a. Since particle rest masses scale with S(r)/S_0, their world lines do not follow time-like geodesics of the MK metric g_{\\mu\

  5. Conformal transformations and conformal invariance in gravitation

    OpenAIRE

    Dabrowski, Mariusz P.; Garecki, Janusz; Blaschke, David B.

    2008-01-01

    Conformal transformations are frequently used tools in order to study relations between various theories of gravity and the Einstein relativity. In this paper we discuss the rules of these transformations for geometric quantities as well as for the matter energy-momentum tensor. We show the subtlety of the matter energy-momentum conservation law which refers to the fact that the conformal transformation "creates" an extra matter term composed of the conformal factor which enters the conservat...

  6. Correlation of MFOLD-predicted DNA secondary structures with separation patterns obtained by capillary electrophoresis single-strand conformation polymorphism (CE-SSCP) analysis.

    Science.gov (United States)

    Glavac, Damjan; Potocnik, Uros; Podpecnik, Darja; Zizek, Teofil; Smerkolj, Sava; Ravnik-Glavac, Metka

    2002-04-01

    We have studied 57 different mutations within three beta-globin gene promoter fragments with sizes 52 bp, 77 bp, and 193 bp by fluorescent capillary electrophoresis CE-SSCP analysis. For each mutation and wild type, energetically most-favorable predicted secondary structures were calculated for sense and antisense strands using the MFOLD DNA-folding algorithm in order to investigate if any correlation exists between predicted DNA structures and actual CE migration time shifts. The overall CE-SSCP detection rate was 100% for all mutations in three studied DNA fragments. For shorter 52 bp and 77 bp DNA fragments we obtained a positive correlation between the migration time shifts and difference in free energy values of predicted secondary structures at all temperatures. For longer 193 bp beta-globin gene fragments with 46 mutations MFOLD predicted different secondary structures for 89% of mutated strands at 25 degrees C and 40 degrees C. However, the magnitude of the mobility shifts did not necessarily correlate with their secondary structures and free energy values except for the sense strand at 40 degrees C where this correlation was statistically significant (r = 0.312, p = 0.033). Results of this study provided more direct insight into the mechanism of CE-SSCP and showed that MFOLD prediction could be helpful in making decisions about the running temperatures and in prediction of CE-SSCP data patterns, especially for shorter (50-100 bp) DNA fragments.

  7. Superspace conformal field theory

    Energy Technology Data Exchange (ETDEWEB)

    Quella, Thomas [Koeln Univ. (Germany). Inst. fuer Theoretische Physik; Schomerus, Volker [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany)

    2013-07-15

    Conformal sigma models and WZW models on coset superspaces provide important examples of logarithmic conformal field theories. They possess many applications to problems in string and condensed matter theory. We review recent results and developments, including the general construction of WZW models on type I supergroups, the classification of conformal sigma models and their embedding into string theory.

  8. Superspace conformal field theory

    International Nuclear Information System (INIS)

    Conformal sigma models and WZW models on coset superspaces provide important examples of logarithmic conformal field theories. They possess many applications to problems in string and condensed matter theory. We review recent results and developments, including the general construction of WZW models on type I supergroups, the classification of conformal sigma models and their embedding into string theory.

  9. Conformal and non Conformal Dilaton Gravity

    CERN Document Server

    Alvarez, Enrique; Mart'\\in, C P

    2014-01-01

    The quantum dynamics of the gravitational field non-minimally coupled to an (also dynamical) scalar field is studied in the broken phase. For a particular value of the coupling the system is classically conformal, and can actually be understood as the group averaging of Einstein-Hilbert's action under conformal transformations. Contradicting cherished beliefs, a conformal anomaly is found in the trace of the equations of motion. To one loop order, this anomaly vanishes on shell. Arguments are given supporting the fact that this does not happen to two loop order, where the anomaly is argued to be a real physical effect.

  10. Conformal Transformations and Accelerated Cosmologies

    OpenAIRE

    Crooks, James L.; Frampton, Paul H.

    2006-01-01

    A cosmological theory that predicts a late-time accelerated attractor with a constant dark matter to dark energy ratio can be said to solve the Coincidence Problem. Such cosmologies are naturally generated in the context of non-standard gravity theories under conformal transformation because of the resulting couplings between scalar fields and matter. The present work examines four classes of these transformed theories and finds that only a small subset--those with a single scalar field--are ...

  11. Phonological Awareness and Rapid Automatized Naming Predicting Early Development in Reading and Spelling: Results from a Cross-Linguistic Longitudinal Study.

    Science.gov (United States)

    Furnes, Bjarte; Samuelsson, Stefan

    2011-02-01

    In this study, the relationship between latent constructs of phonological awareness (PA) and rapid automatized naming (RAN) were investigated and related to later measures of reading and spelling in children learning to read in different alphabetic writing systems (i.e., Norwegian/Swedish vs. English). 750 U.S./Australian children and 230 Scandinavian children were followed longitudinally between kindergarten and 2nd grade. PA and RAN were measured in kindergarten and Grade 1, while word recognition, phonological decoding, and spelling were measured in kindergarten, Grade 1, and Grade 2. In general, high stability was observed for the various reading and spelling measures, such that little additional variance was left open for PA and RAN. However, results demonstrated that RAN was more related to reading than spelling across orthographies, with the opposite pattern shown for PA. In addition, tests of measurement invariance show that the factor loadings of each observed indicator on the latent PA factor was the same across U.S./Australia and Scandinavia. Similar findings were obtained for RAN. In general, tests of structural invariance show that models of early literacy development are highly transferable across languages.

  12. What Automaticity Deficit? Activation of Lexical Information by Readers with Dyslexia in a Rapid Automatized Naming Stroop-Switch Task

    Science.gov (United States)

    Jones, Manon W.; Snowling, Margaret J.; Moll, Kristina

    2016-01-01

    Reading fluency is often predicted by rapid automatized naming (RAN) speed, which as the name implies, measures the automaticity with which familiar stimuli (e.g., letters) can be retrieved and named. Readers with dyslexia are considered to have less "automatized" access to lexical information, reflected in longer RAN times compared with…

  13. A Comparative Study between SVM and Fuzzy Inference System for the Automatic Prediction of Sleep Stages and the Assessment of Sleep Quality

    Directory of Open Access Journals (Sweden)

    John Gialelis

    2015-11-01

    Full Text Available This paper compares two supervised learning algorithms for predicting the sleep stages based on the human brain activity. The first step of the presented work regards feature extraction from real human electroencephalography (EEG data together with its corresponding sleep stages that are utilized for training a support vector machine (SVM, and a fuzzy inference system (FIS algorithm. Then, the trained algorithms are used to predict the sleep stages of real human patients. Extended comparison results are demonstrated which indicate that both classifiers could be utilized as a basis for an unobtrusive sleep quality assessment.

  14. A probabilistic model of RNA conformational space

    DEFF Research Database (Denmark)

    Frellsen, Jes; Moltke, Ida; Thiim, Martin;

    2009-01-01

    The increasing importance of non-coding RNA in biology and medicine has led to a growing interest in the problem of RNA 3-D structure prediction. As is the case for proteins, RNA 3-D structure prediction methods require two key ingredients: an accurate energy function and a conformational sampling...... procedure. Both are only partly solved problems. Here, we focus on the problem of conformational sampling. The current state of the art solution is based on fragment assembly methods, which construct plausible conformations by stringing together short fragments obtained from experimental structures. However...... efficient sampling of RNA conformations in continuous space, and with associated probabilities. We show that the model captures several key features of RNA structure, such as its rotameric nature and the distribution of the helix lengths. Furthermore, the model readily generates native-like 3-D...

  15. Does gender diversity promote non-conformity?

    OpenAIRE

    Amini, Makan; Ekström, Mathias; Ellingsen, Tore; Johannesson, Magnus; Strömsten, Fredrik

    2015-01-01

    Failure to express minority views may distort the behavior of company boards, committees, juries, and other decision-making bodies. Devising a new experimental procedure to measure such conformity in a judgment task, we compare the degree of conformity in groups with varying gender composition. Overall, our experiments offer little evidence that gender composition affects expression of minority views. A robust finding is that a subject's lack of ability predicts both a true propensity to acce...

  16. Prediction

    CERN Document Server

    Sornette, Didier

    2010-01-01

    This chapter first presents a rather personal view of some different aspects of predictability, going in crescendo from simple linear systems to high-dimensional nonlinear systems with stochastic forcing, which exhibit emergent properties such as phase transitions and regime shifts. Then, a detailed correspondence between the phenomenology of earthquakes, financial crashes and epileptic seizures is offered. The presented statistical evidence provides the substance of a general phase diagram for understanding the many facets of the spatio-temporal organization of these systems. A key insight is to organize the evidence and mechanisms in terms of two summarizing measures: (i) amplitude of disorder or heterogeneity in the system and (ii) level of coupling or interaction strength among the system's components. On the basis of the recently identified remarkable correspondence between earthquakes and seizures, we present detailed information on a class of stochastic point processes that has been found to be particu...

  17. Conformal Bootstrap in Embedding Space

    CERN Document Server

    Fortin, Jean-François

    2016-01-01

    It is shown how to obtain conformal blocks from embedding space with the help of the operator product expansion. The minimal conformal block originates from scalar exchange in a four-point correlation functions of four scalars. All remaining conformal blocks are simple derivatives of the minimal conformal block. With the help of the orthogonality properties of the conformal blocks, the analytic conformal bootstrap can be implemented directly in embedding space, leading to a Jacobi-like definition of conformal field theories.

  18. Conformal bootstrap in embedding space

    Science.gov (United States)

    Fortin, Jean-François; Skiba, Witold

    2016-05-01

    It is shown how to obtain conformal blocks from embedding space with the help of the operator product expansion. The minimal conformal block originates from scalar exchange in a four-point correlation function of four scalars. All remaining conformal blocks are simple derivatives of the minimal conformal block. With the help of the orthogonality properties of the conformal blocks, the analytic conformal bootstrap can be implemented directly in embedding space, leading to a Jacobi-like definition of conformal field theories.

  19. Conformational stability of calreticulin

    DEFF Research Database (Denmark)

    Jørgensen, Charlotte S; Trandum, Christa; Larsen, Nanna Brink;

    2005-01-01

    The conformational stability of calreticulin was investigated. Apparent unfolding temperatures (Tm) increased from 31 degrees C at pH 5 to 51 degrees C at pH 9, but electrophoretic analysis revealed that calreticulin oligomerized instead of unfolding. Structural analyses showed that the single C......-terminal alpha-helix was of major importance to the conformational stability of calreticulin....

  20. Conformational stability of calreticulin

    DEFF Research Database (Denmark)

    Jørgensen, C.S.; Trandum, C.; Larsen, N.;

    2005-01-01

    The conformational stability of calreticulin was investigated. Apparent unfolding temperatures (T-m) increased from 31 degrees C at pH 5 to 51 degrees C at pH 9, but electrophoretic analysis revealed that calreticulin oligomerized instead of unfolding. Structural analyses showed that the single C......-terminal a-helix was of major importance to the conformational stability of calreticulin....

  1. The conforming brain and deontological resolve.

    Directory of Open Access Journals (Sweden)

    Melanie Pincus

    Full Text Available Our personal values are subject to forces of social influence. Deontological resolve captures how strongly one relies on absolute rules of right and wrong in the representation of one's personal values and may predict willingness to modify one's values in the presence of social influence. Using fMRI, we found that a neurobiological metric for deontological resolve based on relative activity in the ventrolateral prefrontal cortex (VLPFC during the passive processing of sacred values predicted individual differences in conformity. Individuals with stronger deontological resolve, as measured by greater VLPFC activity, displayed lower levels of conformity. We also tested whether responsiveness to social reward, as measured by ventral striatal activity during social feedback, predicted variability in conformist behavior across individuals but found no significant relationship. From these results we conclude that unwillingness to conform to others' values is associated with a strong neurobiological representation of social rules.

  2. The conforming brain and deontological resolve.

    Science.gov (United States)

    Pincus, Melanie; LaViers, Lisa; Prietula, Michael J; Berns, Gregory

    2014-01-01

    Our personal values are subject to forces of social influence. Deontological resolve captures how strongly one relies on absolute rules of right and wrong in the representation of one's personal values and may predict willingness to modify one's values in the presence of social influence. Using fMRI, we found that a neurobiological metric for deontological resolve based on relative activity in the ventrolateral prefrontal cortex (VLPFC) during the passive processing of sacred values predicted individual differences in conformity. Individuals with stronger deontological resolve, as measured by greater VLPFC activity, displayed lower levels of conformity. We also tested whether responsiveness to social reward, as measured by ventral striatal activity during social feedback, predicted variability in conformist behavior across individuals but found no significant relationship. From these results we conclude that unwillingness to conform to others' values is associated with a strong neurobiological representation of social rules.

  3. Protein local conformations arise from a mixture of Gaussian distributions

    Indian Academy of Sciences (India)

    Ashish V Tendulkar; Babatunde Ogunnaike; Pramod P Wangikar

    2007-08-01

    The classical approaches for protein structure prediction rely either on homology of the protein sequence with a template structure or on ab initio calculations for energy minimization. These methods suffer from disadvantages such as the lack of availability of homologous template structures or intractably large conformational search space, respectively. The recently proposed fragment library based approaches first predict the local structures, which can be used in conjunction with the classical approaches of protein structure prediction. The accuracy of the predictions is dependent on the quality of the fragment library. In this work, we have constructed a library of local conformation classes purely based on geometric similarity. The local conformations are represented using Geometric Invariants, properties that remain unchanged under transformations such as translation and rotation, followed by dimension reduction via principal component analysis. The local conformations are then modeled as a mixture of Gaussian probability distribution functions (PDF). Each one of the Gaussian PDF’s corresponds to a conformational class with the centroid representing the average structure of that class. We find 46 classes when we use an octapeptide as a unit of local conformation. The protein 3-D structure can now be described as a sequence of local conformational classes. Further, it was of interest to see whether the local conformations can be predicted from the amino acid sequences. To that end, we have analyzed the correlation between sequence features and the conformational classes.

  4. An automated efficient conformation search of L-serine by the scaled hypersphere search method

    Science.gov (United States)

    Kishimoto, Naoki; Harayama, Manami; Ohno, Koichi

    2016-05-01

    Stable conformers of L-serine were automatically explored by applications of the scaled hypersphere search (SHS) method to equilibrium structures maintaining the chemical bond skeletons of serine. Energy barriers for conformational changes of L-serine were estimated from the heights of obtained transition structures. Zero-point-corrected electronic energies and Gibbs free energies of the 24 lowest energy conformers and 21 transition structures were calculated at 100, 298, and 400 K by a composite quantum chemistry method (Gaussian-4). Relative populations of 24 conformers including nine new conformers were calculated from the Gibbs energies assuming thermal equilibrium.

  5. Conformal Gravity rotation curves with a conformal Higgs halo

    Science.gov (United States)

    Horne, Keith

    2016-06-01

    We discuss the effect of a conformally coupled Higgs field on conformal gravity (CG) predictions for the rotation curves of galaxies. The Mannheim-Kazanas (MK) metric is a valid vacuum solution of CG's fourth-order Poisson equation if and only if the Higgs field has a particular radial profile, S(r) = S0 a/(r + a), decreasing from S0 at r = 0 with radial scalelength a. Since particle rest masses scale with S(r)/S0, their world lines do not follow time-like geodesics of the MK metric gμν, as previously assumed, but rather those of the Higgs-frame MK metric tilde{g}_{μ ν }=Ω ^2 g_{μ ν }, with the conformal factor Ω(r) = S(r)/S0. We show that the required stretching of the MK metric exactly cancels the linear potential that has been invoked to fit galaxy rotation curves without dark matter. We also formulate, for spherical structures with a Higgs halo S(r), the CG equations that must be solved for viable astrophysical tests of CG using galaxy and cluster dynamics and lensing.

  6. Conformational elasticity theory of chain molecules

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    This paper develops a conformational elasticity theory of chain molecules, which is based on three key points: (ⅰ) the molecular model is the rotational isomeric state (RIS) model; (ⅱ) the conformational distribution function of a chain molecule is described by a function of two variables, the end-to-end distance of a chain conformation and the energy of the conformation; (ⅲ) the rule of changes in the chain conformational states during deformation is that a number of chain conformations would vanish. The ideal deformation behavior calculated by the theory shows that the change in chain conformations is physically able to make the upward curvature of the stress-strain curve at the large-scale deformation of natural rubber. With the theory, different deformation behaviors between polymers with different chemical structures can be described, the energy term of the stress in the deformations can be predicted, and for natural rubber the fraction of the energy term is around 13%, coinciding with the experimental results.

  7. PubChem3D: Conformer generation

    Directory of Open Access Journals (Sweden)

    Bolton Evan E

    2011-01-01

    lower energy windows. Overall average accuracy of reproduction of bioactive conformations was remarkably linear with respect to both non-hydrogen atom count ("size" and effective rotor count ("flexibility". Using these as independent variables, a regression equation was developed to predict the RMSD accuracy of a theoretical ensemble to reproduce bioactive conformations. The equation was modified to give a minimum RMSD conformer sampling value to help ensure that 90% of the sampled theoretical models should contain at least one conformer within the RMSD sampling value to a "bioactive" conformation. Conclusion Optimal parameters for conformer generation using OMEGA were explored and determined. An equation was developed that provides an RMSD sampling value to use that is based on the relative accuracy to reproduce bioactive conformations. The optimal conformer generation parameters and RMSD sampling values determined are used by the PubChem3D project to generate theoretical conformer models.

  8. Conformal Predictions in Multimedia Pattern Recognition

    Science.gov (United States)

    Nallure Balasubramanian, Vineeth

    2010-01-01

    The fields of pattern recognition and machine learning are on a fundamental quest to design systems that can learn the way humans do. One important aspect of human intelligence that has so far not been given sufficient attention is the capability of humans to express when they are certain about a decision, or when they are not. Machine learning…

  9. Objective interpretation as conforming interpretation

    Directory of Open Access Journals (Sweden)

    Lidka Rodak

    2011-12-01

    Full Text Available The practical discourse willingly uses the formula of “objective interpretation”, with no regards to its controversial nature that has been discussed in literature.The main aim of the article is to investigate what “objective interpretation” could mean and how it could be understood in the practical discourse, focusing on the understanding offered by judicature.The thesis of the article is that objective interpretation, as identified with textualists’ position, is not possible to uphold, and should be rather linked with conforming interpretation. And what this actually implies is that it is not the virtue of certainty and predictability – which are usually associated with objectivity- but coherence that makes the foundation of applicability of objectivity in law.What could be observed from the analyses, is that both the phenomenon of conforming interpretation and objective interpretation play the role of arguments in the interpretive discourse, arguments that provide justification that interpretation is not arbitrary or subjective. With regards to the important part of the ideology of legal application which is the conviction that decisions should be taken on the basis of law in order to exclude arbitrariness, objective interpretation could be read as a question “what kind of authority “supports” certain interpretation”? that is almost never free of judicial creativity and judicial activism.One can say that, objective and conforming interpretation are just another arguments used in legal discourse.

  10. Normal-Mode-Analysis–Monitored Energy Minimization Procedure for Generating Small–Molecule Bound Conformations

    OpenAIRE

    Wang, Qi; Pang, Yuan-Ping

    2007-01-01

    The energy minimization of a small molecule alone does not automatically stop at a local minimum of the potential energy surface of the molecule if the minimum is shallow, thus leading to folding of the molecule and consequently hampering the generation of the bound conformation of a guest in the absence of its host. This questions the practicality of virtual screening methods that use conformations at local minima of their potential energy surfaces (local minimum conformations) as potential ...

  11. Conformal expansions and renormalons

    CERN Document Server

    Gardi, E; Gardi, Einan; Grunberg, Georges

    2001-01-01

    The large-order behaviour of QCD is dominated by renormalons. On the other hand renormalons do not occur in conformal theories, such as the one describing the infrared fixed-point of QCD at small beta_0 (the Banks--Zaks limit). Since the fixed-point has a perturbative realization, all-order perturbative relations exist between the conformal coefficients, which are renormalon-free, and the standard perturbative coefficients, which contain renormalons. Therefore, an explicit cancellation of renormalons should occur in these relations. The absence of renormalons in the conformal limit can thus be seen as a constraint on the structure of the QCD perturbative expansion. We show that the conformal constraint is non-trivial: a generic model for the large-order behaviour violates it. We also analyse a specific example, based on a renormalon-type integral over the two-loop running-coupling, where the required cancellation does occur.

  12. [Conformers of carnosine].

    Science.gov (United States)

    Kliuev, S A

    2006-01-01

    The geometric and energetic parameters of most stable conformations of carnosine were calculated by the semiempirical guantum-chemical method PM3. The carnosine-water-zinc (II) clusters were simulated. PMID:16909845

  13. Automatic Fiscal Stabilizers

    Directory of Open Access Journals (Sweden)

    Narcis Eduard Mitu

    2013-11-01

    Full Text Available Policies or institutions (built into an economic system that automatically tend to dampen economic cycle fluctuations in income, employment, etc., without direct government intervention. For example, in boom times, progressive income tax automatically reduces money supply as incomes and spendings rise. Similarly, in recessionary times, payment of unemployment benefits injects more money in the system and stimulates demand. Also called automatic stabilizers or built-in stabilizers.

  14. Automatic input rectification

    OpenAIRE

    Long, Fan; Ganesh, Vijay; Carbin, Michael James; Sidiroglou, Stelios; Rinard, Martin

    2012-01-01

    We present a novel technique, automatic input rectification, and a prototype implementation, SOAP. SOAP learns a set of constraints characterizing typical inputs that an application is highly likely to process correctly. When given an atypical input that does not satisfy these constraints, SOAP automatically rectifies the input (i.e., changes the input so that it satisfies the learned constraints). The goal is to automatically convert potentially dangerous inputs into typical inputs that the ...

  15. Quantum massive conformal gravity

    International Nuclear Information System (INIS)

    We first find the linear approximation of the second plus fourth order derivative massive conformal gravity action. Then we reduce the linearized action to separated second order derivative terms, which allows us to quantize the theory by using the standard first order canonical quantization method. It is shown that quantum massive conformal gravity is renormalizable but has ghost states. A possible decoupling of these ghost states at high energies is discussed. (orig.)

  16. Quantum massive conformal gravity

    OpenAIRE

    Faria, F. F.

    2016-01-01

    We first find the linear approximation of the second plus fourth order derivative massive conformal gravity action. Then we reduce the linearized action to separated second order derivative terms, which allows us to quantize the theory by using the standard first order canonical quantization method. It is shown that quantum massive conformal gravity is renormalizable but has ghost states. A possible decoupling of these ghost states at high energies is discussed.

  17. Quantum massive conformal gravity

    Science.gov (United States)

    Faria, F. F.

    2016-04-01

    We first find the linear approximation of the second plus fourth order derivative massive conformal gravity action. Then we reduce the linearized action to separated second order derivative terms, which allows us to quantize the theory by using the standard first order canonical quantization method. It is shown that quantum massive conformal gravity is renormalizable but has ghost states. A possible decoupling of these ghost states at high energies is discussed.

  18. Quantum massive conformal gravity

    Energy Technology Data Exchange (ETDEWEB)

    Faria, F.F. [Universidade Estadual do Piaui, Centro de Ciencias da Natureza, Teresina, PI (Brazil)

    2016-04-15

    We first find the linear approximation of the second plus fourth order derivative massive conformal gravity action. Then we reduce the linearized action to separated second order derivative terms, which allows us to quantize the theory by using the standard first order canonical quantization method. It is shown that quantum massive conformal gravity is renormalizable but has ghost states. A possible decoupling of these ghost states at high energies is discussed. (orig.)

  19. Automatic differentiation bibliography

    Energy Technology Data Exchange (ETDEWEB)

    Corliss, G.F. (comp.)

    1992-07-01

    This is a bibliography of work related to automatic differentiation. Automatic differentiation is a technique for the fast, accurate propagation of derivative values using the chain rule. It is neither symbolic nor numeric. Automatic differentiation is a fundamental tool for scientific computation, with applications in optimization, nonlinear equations, nonlinear least squares approximation, stiff ordinary differential equation, partial differential equations, continuation methods, and sensitivity analysis. This report is an updated version of the bibliography which originally appeared in Automatic Differentiation of Algorithms: Theory, Implementation, and Application.

  20. The Biological Bases of Conformity

    Directory of Open Access Journals (Sweden)

    Thomas Joshau Henry Morgan

    2012-06-01

    Full Text Available Humans are characterized by an extreme dependence on culturally transmitted information and recent formal theory predicts that natural selection should favour adaptive learning strategies that facilitate effective use of social information in decision making. One strategy that has attracted particular attention is conformist transmission, defined as the disproportionately likely adoption of the most common variant. Conformity has historically been emphasized as significant in the social psychology literature, and recently there have also been reports of conformist behaviour in nonhuman animals. However, mathematical analyses differ in how important and widespread they expect conformity to be, and relevant experimental work is scarce, and generates findings that are both mutually contradictory and inconsistent with the predictions of the models. We review the relevant literature considering the causation, function, history and ontogeny of conformity and describe a computer-based experiment on human subjects that we carried out in order to resolve ambiguities. We found that only when many demonstrators were available and subjects were uncertain was subject behaviour conformist. A further analysis found that the underlying response to social information alone was generally conformist. Thus, our data are consistent with a conformist use of social information, but as subject’s behaviour is the result of both social and asocial influences, the resultant behaviour may not be conformist. We end by relating these findings to an embryonic cognitive neuroscience literature that has recently begun to explore the neural bases of social learning. Here conformist transmission may be a particularly useful case study, not only because there are well-defined and tractable opportunities to characterize the biological underpinnings of this form of social learning, but also because early findings imply that humans may possess specific cognitive adaptations for

  1. Controlling complex networks with conformity behavior

    Science.gov (United States)

    Wang, Xu-Wen; Nie, Sen; Wang, Wen-Xu; Wang, Bing-Hong

    2015-09-01

    Controlling complex networks accompanied by common conformity behavior is a fundamental problem in social and physical science. Conformity behavior that individuals tend to follow the majority in their neighborhood is common in human society and animal communities. Despite recent progress in understanding controllability of complex networks, the existent controllability theories cannot be directly applied to networks associated with conformity. Here we propose a simple model to incorporate conformity-based decision making into the evolution of a network system, which allows us to employ the exact controllability theory to explore the controllability of such systems. We offer rigorous theoretical results of controllability for representative regular networks. We also explore real networks in different fields and some typical model networks, finding some interesting results that are different from the predictions of structural and exact controllability theory in the absence of conformity. We finally present an example of steering a real social network to some target states to further validate our controllability theory and tools. Our work offers a more realistic understanding of network controllability with conformity behavior and can have potential applications in networked evolutionary games, opinion dynamics and many other complex networked systems.

  2. Automatic contrast: evidence that automatic comparison with the social self affects evaluative responses.

    Science.gov (United States)

    Ruys, Kirsten I; Spears, Russell; Gordijn, Ernestine H; de Vries, Nanne K

    2007-08-01

    The aim of the present research was to investigate whether unconsciously presented affective information may cause opposite evaluative responses depending on what social category the information originates from. We argue that automatic comparison processes between the self and the unconscious affective information produce this evaluative contrast effect. Consistent with research on automatic behaviour, we propose that when an intergroup context is activated, an automatic comparison to the social self may determine the automatic evaluative responses, at least for highly visible categories (e.g. sex, ethnicity). Contrary to previous research on evaluative priming, we predict automatic contrastive responses to affective information originating from an outgroup category such that the evaluative response to neutral targets is opposite to the valence of the suboptimal primes. Two studies using different intergroup contexts provide support for our hypotheses. PMID:17705936

  3. Normal-mode-analysis-monitored energy minimization procedure for generating small-molecule bound conformations.

    Directory of Open Access Journals (Sweden)

    Qi Wang

    Full Text Available The energy minimization of a small molecule alone does not automatically stop at a local minimum of the potential energy surface of the molecule if the minimum is shallow, thus leading to folding of the molecule and consequently hampering the generation of the bound conformation of a guest in the absence of its host. This questions the practicality of virtual screening methods that use conformations at local minima of their potential energy surfaces (local minimum conformations as potential bound conformations. Here we report a normal-mode-analysis-monitored energy minimization (NEM procedure that generates local minimum conformations as potential bound conformations. Of 22 selected guest-host complex crystal structures with guest structures possessing up to four rotatable bonds, all complexes were reproduced, with guest mass-weighted root mean square deviations of <1.0 A, through docking with the NEM-generated guest local minimum conformations. An analysis of the potential energies of these local minimum conformations showed that 22 (100%, 18 (82%, 16 (73%, and 12 (55% of the 22 guest bound conformations in the crystal structures had conformational strain energies of less than or equal to 3.8, 2.0, 0.6, and 0.0 kcal/mol, respectively. These results suggest that (1 the NEM procedure can generate small-molecule bound conformations, and (2 guests adopt low-strain-energy conformations for complexation, thus supporting the virtual screening methods that use local minimum conformations.

  4. Charged conformal Killing spinors

    Energy Technology Data Exchange (ETDEWEB)

    Lischewski, Andree, E-mail: lischews@mathematik.hu-berlin.de [Humboldt-Universität zu Berlin, Institut für Mathematik, Rudower Chaussee 25, Room 1.310, D12489 Berlin (Germany)

    2015-01-15

    We study the twistor equation on pseudo-Riemannian Spin{sup c}-manifolds whose solutions we call charged conformal Killing spinors (CCKSs). We derive several integrability conditions for the existence of CCKS and study their relations to spinor bilinears. A construction principle for Lorentzian manifolds admitting CCKS with nontrivial charge starting from CR-geometry is presented. We obtain a partial classification result in the Lorentzian case under the additional assumption that the associated Dirac current is normal conformal and complete the classification of manifolds admitting CCKS in all dimensions and signatures ≤5 which has recently been initiated in the study of supersymmetric field theories on curved space.

  5. MARZ: Manual and automatic redshifting software

    Science.gov (United States)

    Hinton, S. R.; Davis, Tamara M.; Lidman, C.; Glazebrook, K.; Lewis, G. F.

    2016-04-01

    The Australian Dark Energy Survey (OzDES) is a 100-night spectroscopic survey underway on the Anglo-Australian Telescope using the fibre-fed 2-degree-field (2dF) spectrograph. We have developed a new redshifting application MARZ with greater usability, flexibility, and the capacity to analyse a wider range of object types than the RUNZ software package previously used for redshifting spectra from 2dF. MARZ is an open-source, client-based, Javascript web-application which provides an intuitive interface and powerful automatic matching capabilities on spectra generated from the AAOmega spectrograph to produce high quality spectroscopic redshift measurements. The software can be run interactively or via the command line, and is easily adaptable to other instruments and pipelines if conforming to the current FITS file standard is not possible. Behind the scenes, a modified version of the AUTOZ cross-correlation algorithm is used to match input spectra against a variety of stellar and galaxy templates, and automatic matching performance for OzDES spectra has increased from 54% (RUNZ) to 91% (MARZ). Spectra not matched correctly by the automatic algorithm can be easily redshifted manually by cycling automatic results, manual template comparison, or marking spectral features.

  6. Game Theory and Social Psychology: Conformity Games

    Science.gov (United States)

    Alessio, Danielle; Kilgour, D. Marc

    2011-11-01

    Game models can contribute to understanding of how social biases and pressures to conform can lead to puzzling behaviour in social groups. A model of the psychological biases false uniqueness and false consensus is set out. The model predicts the phenomenon of pluralistic ignorance, which is well-studied in social psychology, showing how it arises as a result of the prevalence of false uniqueness and the desire to conform. An efficient method is developed for finding Nash equilibria of the model under certain restrictions.

  7. On the physical origin of galactic conformity

    Science.gov (United States)

    Hearin, Andrew P.; Behroozi, Peter S.; van den Bosch, Frank C.

    2016-09-01

    Correlations between the star formation rates (SFRs) of nearby galaxies (so-called galactic conformity) have been observed for projected separations up to 4 Mpc, an effect not predicted by current semi-analytic models. We investigate correlations between the mass accretion rates (dMvir/dt) of nearby haloes as a potential physical origin for this effect. We find that pairs of host haloes `know about' each others' assembly histories even when their present-day separation is greater than thirty times the virial radius of either halo. These distances are far too large for direct interaction between the haloes to explain the correlation in their dMvir/dt. Instead, halo pairs at these distances reside in the same large-scale tidal environment, which regulates dMvir/dt for both haloes. Larger haloes are less affected by external forces, which naturally gives rise to a mass dependence of the halo conformity signal. SDSS measurements of galactic conformity exhibit a qualitatively similar dependence on stellar mass, including how the signal varies with distance. Based on the expectation that halo accretion and galaxy SFR are correlated, we predict the scale-, mass- and redshift-dependence of large-scale galactic conformity, finding that the signal should drop to undetectable levels by z ≳ 1. These predictions are testable with current surveys to z ˜ 1; confirmation would establish a strong correlation between dark matter halo accretion rate and central galaxy SFR.

  8. The Pseudo-Conformal Universe: Scale Invariance from Spontaneous Breaking of Conformal Symmetry

    CERN Document Server

    Hinterbichler, Kurt

    2011-01-01

    We present a novel theory of the very early universe which addresses the traditional horizon and flatness problems of big bang cosmology and predicts a scale invariant spectrum of perturbations. Unlike inflation, this scenario requires no exponential superluminal expansion of space-time. Instead, the early universe is described by a conformal field theory minimally coupled to gravity. The conformal fields develop a time-dependent expectation value which breaks the flat space so(4,2) conformal symmetry down to so(4,1), the symmetries of de Sitter, giving perturbations a scale invariant spectrum. The solution is an attractor, at least in the case of a single time-dependent field. Meanwhile, the metric background remains approximately flat but slowly contracts, which makes the universe increasingly flat, homogeneous and isotropic, akin to the smoothing mechanism of ekpyrotic cosmology. Our scenario is very general, requiring only a conformal field theory capable of developing the appropriate time-dependent expec...

  9. Conformal special relativity

    International Nuclear Information System (INIS)

    It is shown that the information loss/recovery theorem based on the ADS/CFT correspondence is not consistent with the stability of the Schwarzschild or Reissner-Nordstrom black holes. Nonetheless, the conformal invariance of Yang-Mills theory points to new relativity principle compatible with quantum unitarity near those black holes

  10. Extende conformal field theories

    Energy Technology Data Exchange (ETDEWEB)

    Taormina, A. (Chicago Univ., IL (USA). Enrico Fermi Inst.)

    1990-08-01

    Some extended conformal field theories are briefly reviewed. They illustrate how non minimal models of the Virasoro algebra (c{ge}1) can become minimal with respect to a larger algebra. The accent is put on N-extended superconformal algebras, which are relevant in superstring compactification. (orig.).

  11. Extended conformal field theories

    Science.gov (United States)

    Taormina, Anne

    1990-08-01

    Some extended conformal field theories are briefly reviewed. They illustrate how non minimal models of the Virasoro algebra (c≥1) can become minimal with respect to a larger algebra. The accent is put on N-extended superconformal algebras, which are relevant in superstring compactification.

  12. Conformal General Relativity

    CERN Document Server

    Pervushin, V

    2001-01-01

    The inflation-free solution of problems of the modern cosmology (horizon, cosmic initial data, Planck era, arrow of time, singularity,homogeneity, and so on) is considered in the conformal-invariant unified theory given in the space with geometry of similarity where we can measure only the conformal-invariant ratio of all quantities. Conformal General Relativity is defined as the $SU_c(3)\\times SU(2)\\times U(1)$-Standard Model where the dimensional parameter in the Higgs potential is replaced by a dilaton scalar field described by the negative Penrose-Chernikov-Tagirov action. Spontaneous SU(2) symmetry breaking is made on the level of the conformal-invariant angle of the dilaton-Higgs mixing, and it allows us to keep the structure of Einstein's theory with the equivalence principle. We show that the lowest order of the linearized equations of motion solves the problems mentioned above and describes the Cold Universe Scenario with the constant temperature T and z-history of all masses with respect to an obser...

  13. Automatic Payroll Deposit System.

    Science.gov (United States)

    Davidson, D. B.

    1979-01-01

    The Automatic Payroll Deposit System in Yakima, Washington's Public School District No. 7, directly transmits each employee's salary amount for each pay period to a bank or other financial institution. (Author/MLF)

  14. Sampling Realistic Protein Conformations Using Local Structural Bias

    DEFF Research Database (Denmark)

    Hamelryck, Thomas Wim; Kent, John T.; Krogh, A.

    2006-01-01

    The prediction of protein structure from sequence remains a major unsolved problem in biology. The most successful protein structure prediction methods make use of a divide-and-conquer strategy to attack the problem: a conformational sampling method generates plausible candidate structures, which......-reaching implications for protein structure prediction, determination, simulation, and design....

  15. A Conformal Extension Theorem based on Null Conformal Geodesics

    CERN Document Server

    Lübbe, Christian

    2008-01-01

    In this article we describe the formulation of null geodesics as null conformal geodesics and their description in the tractor formalism. A conformal extension theorem through an isotropic singularity is proven by requiring the boundedness of the tractor curvature and its derivatives to sufficient order along a congruence of null conformal geodesic. This article extends earlier work by Tod and Luebbe.

  16. CONFORMANCE IMPROVEMENT USING GELS

    Energy Technology Data Exchange (ETDEWEB)

    Randall S. Seright

    2004-09-30

    This report describes work performed during the third and final year of the project, ''Conformance Improvement Using Gels.'' Corefloods revealed throughput dependencies of permeability reduction by polymers and gels that were much more prolonged during oil flow than water flow. This behavior was explained using simple mobility ratio arguments. A model was developed that quantitatively fits the results and predicts ''clean up'' times for oil productivity when production wells are returned to service after application of a polymer or gel treatment. X-ray computed microtomography studies of gels in strongly water-wet Berea sandstone and strongly oil-wet porous polyethylene suggested that oil penetration through gel-filled pores occurs by a gel-dehydration mechanism, rather than gel-ripping or gel-displacement mechanisms. In contrast, analysis of data from the University of Kansas suggests that the gel-ripping or displacement mechanisms are more important in more permeable, strongly water-wet sandpacks. These findings help to explain why aqueous gels can reduce permeability to water more than to oil under different conditions. Since cement is the most commonly used material for water shutoff, we considered when gels are preferred over cements. Our analysis and experimental results indicated that cement cannot be expected to completely fill (top to bottom) a vertical fracture of any width, except near the wellbore. For vertical fractures with apertures less than 4 mm, the cement slurry will simply not penetrate very far into the fracture. For vertical fractures with apertures greater than 4 mm, the slurry may penetrate a substantial distance into the bottom part of the fracture. However, except near the wellbore, the upper part of the fracture will remain open due to gravity segregation. We compared various approaches to plugging fractures using gels, including (1) varying polymer content, (2) varying placement (extrusion) rate

  17. Logarithmic conformal field theory

    Science.gov (United States)

    Gainutdinov, Azat; Ridout, David; Runkel, Ingo

    2013-12-01

    Conformal field theory (CFT) has proven to be one of the richest and deepest subjects of modern theoretical and mathematical physics research, especially as regards statistical mechanics and string theory. It has also stimulated an enormous amount of activity in mathematics, shaping and building bridges between seemingly disparate fields through the study of vertex operator algebras, a (partial) axiomatisation of a chiral CFT. One can add to this that the successes of CFT, particularly when applied to statistical lattice models, have also served as an inspiration for mathematicians to develop entirely new fields: the Schramm-Loewner evolution and Smirnov's discrete complex analysis being notable examples. When the energy operator fails to be diagonalisable on the quantum state space, the CFT is said to be logarithmic. Consequently, a logarithmic CFT is one whose quantum space of states is constructed from a collection of representations which includes reducible but indecomposable ones. This qualifier arises because of the consequence that certain correlation functions will possess logarithmic singularities, something that contrasts with the familiar case of power law singularities. While such logarithmic singularities and reducible representations were noted by Rozansky and Saleur in their study of the U (1|1) Wess-Zumino-Witten model in 1992, the link between the non-diagonalisability of the energy operator and logarithmic singularities in correlators is usually ascribed to Gurarie's 1993 article (his paper also contains the first usage of the term 'logarithmic conformal field theory'). The class of CFTs that were under control at this time was quite small. In particular, an enormous amount of work from the statistical mechanics and string theory communities had produced a fairly detailed understanding of the (so-called) rational CFTs. However, physicists from both camps were well aware that applications from many diverse fields required significantly more

  18. Computation of conformational coupling in allosteric proteins.

    Directory of Open Access Journals (Sweden)

    Brian A Kidd

    2009-08-01

    Full Text Available In allosteric regulation, an effector molecule binding a protein at one site induces conformational changes, which alter structure and function at a distant active site. Two key challenges in the computational modeling of allostery are the prediction of the structure of one allosteric state starting from the structure of the other, and elucidating the mechanisms underlying the conformational coupling of the effector and active sites. Here we approach these two challenges using the Rosetta high-resolution structure prediction methodology. We find that the method can recapitulate the relaxation of effector-bound forms of single domain allosteric proteins into the corresponding ligand-free states, particularly when sampling is focused on regions known to change conformation most significantly. Analysis of the coupling between contacting pairs of residues in large ensembles of conformations spread throughout the landscape between and around the two allosteric states suggests that the transitions are built up from blocks of tightly coupled interacting sets of residues that are more loosely coupled to one another.

  19. Multiscale conformal pattern transfer

    Science.gov (United States)

    Lodewijks, Kristof; Miljkovic, Vladimir; Massiot, Inès; Mekonnen, Addis; Verre, Ruggero; Olsson, Eva; Dmitriev, Alexandre

    2016-06-01

    We demonstrate a method for seamless transfer from a parent flat substrate of basically any lithographic top-down or bottom-up pattern onto essentially any kind of surface. The nano- or microscale patterns, spanning macroscopic surface areas, can be transferred with high conformity onto a large variety of surfaces when such patterns are produced on a thin carbon film, grown on top of a sacrificial layer. The latter allows lifting the patterns from the flat parent substrate onto a water-air interface to be picked up by the host surface of choice. We illustrate the power of this technique by functionalizing broad range of materials including glass, plastics, metals, rough semiconductors and polymers, highlighting the potential applications in in situ colorimetry of the chemistry of materials, anti-counterfeit technologies, biomolecular and biomedical studies, light-matter interactions at the nanoscale, conformal photovoltaics and flexible electronics.

  20. Conformational flexibility of aspartame.

    Science.gov (United States)

    Toniolo, Claudio; Temussi, Pierandrea

    2016-05-01

    L-Aspartyl-L-phenylalanine methyl ester, better known as aspartame, is not only one of the most used artificial sweeteners, but also a very interesting molecule with respect to the correlation between molecular structure and taste. The extreme conformational flexibility of this dipeptide posed a huge difficulty when researchers tried to use it as a lead compound to design new sweeteners. In particular, it was difficult to take advantage of its molecular model as a mold to infer the shape of the, then unknown, active site of the sweet taste receptor. Here, we follow the story of the 3D structural aspects of aspartame from early conformational studies to recent docking into homology models of the receptor. © 2016 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 106: 376-384, 2016. PMID:27038223

  1. Conformal Complementarity Maps

    CERN Document Server

    Barbón, José L F

    2013-01-01

    We study quantum cosmological models for certain classes of bang/crunch singularities, using the duality between expanding bubbles in AdS with a FRW interior cosmology and perturbed CFTs on de Sitter space-time. It is pointed out that horizon complementarity in the AdS bulk geometries is realized as a conformal transformation in the dual deformed CFT. The quantum version of this map is described in full detail in a toy model involving conformal quantum mechanics. In this system the complementarity map acts as an exact duality between eternal and apocalyptic Hamiltonian evolutions. We calculate the commutation relation between the Hamiltonians corresponding to the different frames. It vanishes only on scale invariant states.

  2. Conformable light emitting modules

    OpenAIRE

    Jablonski, Michal

    2014-01-01

    As we become increasingly aware that there is more to light than the image it forms on our retina, and as we become more environmentally aware, the value of non-image-forming light increases along with the need for various new light related appliances. In particular, some lighting related applications are emerging which demand conformability (flexibility and stretchability). Well-being, automotive or wearable electronic applications are just a few examples where these trends can be observed. ...

  3. Conformal scalar field wormholes

    Science.gov (United States)

    Halliwell, Jonathan J.; Laflamme, Raymond

    1989-01-01

    The Euclidian Einstein equations with a cosmological constant and a conformally coupled scalar field are solved, taking the metric to be of the Robertson-Walker type. In the case Lambda = 0, solutions are found which represent a wormhole connecting two asymptotically flat Euclidian regions. In the case Lambda greater than 0, the solutions represent tunneling from a small Tolman-like universe to a large Robertson-Walker universe.

  4. The conformal bootstrap

    Science.gov (United States)

    Poland, David; Simmons-Duffin, David

    2016-06-01

    The conformal bootstrap was proposed in the 1970s as a strategy for calculating the properties of second-order phase transitions. After spectacular success elucidating two-dimensional systems, little progress was made on systems in higher dimensions until a recent renaissance beginning in 2008. We report on some of the main results and ideas from this renaissance, focusing on new determinations of critical exponents and correlation functions in the three-dimensional Ising and O(N) models.

  5. Sparse encoding of automatic visual association in hippocampal networks

    DEFF Research Database (Denmark)

    Hulme, Oliver J; Skov, Martin; Chadwick, Martin J;

    2014-01-01

    Intelligent action entails exploiting predictions about associations between elements of ones environment. The hippocampus and mediotemporal cortex are endowed with the network topology, physiology, and neurochemistry to automatically and sparsely code sensori-cognitive associations that can be r...

  6. Conformal boundaries of warped products

    DEFF Research Database (Denmark)

    Kokkendorff, Simon Lyngby

    2006-01-01

    In this note we prove a result on how to determine the conformal boundary of a type of warped product of two length spaces in terms of the individual conformal boundaries. In the situation, that we treat, the warping and conformal distortion functions are functions of distance to a base point....... The result is applied to produce examples of CAT(0)-spaces, where the conformal and ideal boundaries differ in interesting ways....

  7. Random Conformal Weldings

    CERN Document Server

    Astala, K; Kupiainen, A; Saksman, E

    2009-01-01

    We construct a conformally invariant random family of closed curves in the plane by welding of random homeomorphisms of the unit circle. The homeomorphism is constructed using the exponential of $\\beta X$ where $X$ is the restriction of the two dimensional free field on the circle and the parameter $\\beta$ is in the "high temperature" regime $\\beta<\\sqrt 2$. The welding problem is solved by studying a non-uniformly elliptic Beltrami equation with a random complex dilatation. For the existence a method of Lehto is used. This requires sharp probabilistic estimates to control conformal moduli of annuli and they are proven by decomposing the free field as a sum of independent fixed scale fields and controlling the correlations of the complex dilation restricted to dyadic cells of various scales. For uniqueness we invoke a result by Jones and Smirnov on conformal removability of H\\"older curves. We conjecture that our curves are locally related to SLE$(\\kappa)$ for $\\kappa<4$.

  8. Conformal Janus on Euclidean Sphere

    CERN Document Server

    Bak, Dongsu; Rey, Soo-Jong

    2016-01-01

    We interpret Janus as an interface in a conformal field theory and study its properties. The Janus is created by an exactly marginal operator and we study its effect on the interface conformal field theory on the Janus. We do this by utilizing the AdS/CFT correspondence. We compute the interface free energy both from leading correction to the Euclidean action in the dual gravity description and from conformal perturbation theory in the conformal field theory. We find that the two results agree each other and that the interface free energy scales precisely as expected from the conformal invariance of the Janus interface.

  9. An Automatic Hierarchical Delay Analysis Tool

    Institute of Scientific and Technical Information of China (English)

    FaridMheir-El-Saadi; BozenaKaminska

    1994-01-01

    The performance analysis of VLSI integrated circuits(ICs) with flat tools is slow and even sometimes impossible to complete.Some hierarchical tools have been developed to speed up the analysis of these large ICs.However,these hierarchical tools suffer from a poor interaction with the CAD database and poorly automatized operations.We introduce a general hierarchical framework for performance analysis to solve these problems.The circuit analysis is automatic under the proposed framework.Information that has been automatically abstracted in the hierarchy is kept in database properties along with the topological information.A limited software implementation of the framework,PREDICT,has also been developed to analyze the delay performance.Experimental results show that hierarchical analysis CPU time and memory requirements are low if heuristics are used during the abstraction process.

  10. Oocytes Polar Body Detection for Automatic Enucleation

    Directory of Open Access Journals (Sweden)

    Di Chen

    2016-02-01

    Full Text Available Enucleation is a crucial step in cloning. In order to achieve automatic blind enucleation, we should detect the polar body of the oocyte automatically. The conventional polar body detection approaches have low success rate or low efficiency. We propose a polar body detection method based on machine learning in this paper. On one hand, the improved Histogram of Oriented Gradient (HOG algorithm is employed to extract features of polar body images, which will increase success rate. On the other hand, a position prediction method is put forward to narrow the search range of polar body, which will improve efficiency. Experiment results show that the success rate is 96% for various types of polar bodies. Furthermore, the method is applied to an enucleation experiment and improves the degree of automatic enucleation.

  11. Automatic text summarization

    CERN Document Server

    Torres Moreno, Juan Manuel

    2014-01-01

    This new textbook examines the motivations and the different algorithms for automatic document summarization (ADS). We performed a recent state of the art. The book shows the main problems of ADS, difficulties and the solutions provided by the community. It presents recent advances in ADS, as well as current applications and trends. The approaches are statistical, linguistic and symbolic. Several exemples are included in order to clarify the theoretical concepts.  The books currently available in the area of Automatic Document Summarization are not recent. Powerful algorithms have been develop

  12. Automatic utilities auditing

    Energy Technology Data Exchange (ETDEWEB)

    Smith, Colin Boughton [Energy Metering Technology (United Kingdom)

    2000-08-01

    At present, energy audits represent only snapshot situations of the flow of energy. The normal pattern of energy audits as seen through the eyes of an experienced energy auditor is described. A brief history of energy auditing is given. It is claimed that the future of energy auditing lies in automatic meter reading with expert data analysis providing continuous automatic auditing thereby reducing the skill element. Ultimately, it will be feasible to carry out auditing at intervals of say 30 minutes rather than five years.

  13. Automatic Camera Control

    DEFF Research Database (Denmark)

    Burelli, Paolo; Preuss, Mike

    2014-01-01

    Automatically generating computer animations is a challenging and complex problem with applications in games and film production. In this paper, we investigate howto translate a shot list for a virtual scene into a series of virtual camera configurations — i.e automatically controlling the virtual...... camera. We approach this problem by modelling it as a dynamic multi-objective optimisation problem and show how this metaphor allows a much richer expressiveness than a classical single objective approach. Finally, we showcase the application of a multi-objective evolutionary algorithm to generate a shot...

  14. Conformal superalgebras via tractor calculus

    Science.gov (United States)

    Lischewski, Andree

    2015-01-01

    We use the manifestly conformally invariant description of a Lorentzian conformal structure in terms of a parabolic Cartan geometry in order to introduce a superalgebra structure on the space of twistor spinors and normal conformal vector fields formulated in purely algebraic terms on parallel sections in tractor bundles. Via a fixed metric in the conformal class, one reproduces a conformal superalgebra structure that has been considered in the literature before. The tractor approach, however, makes clear that the failure of this object to be a Lie superalgebra in certain cases is due to purely algebraic identities on the spinor module and to special properties of the conformal holonomy representation. Moreover, it naturally generalizes to higher signatures. This yields new formulas for constructing new twistor spinors and higher order normal conformal Killing forms out of existing ones, generalizing the well-known spinorial Lie derivative. Moreover, we derive restrictions on the possible dimension of the space of twistor spinors in any metric signature.

  15. Conformal superalgebras via tractor calculus

    International Nuclear Information System (INIS)

    We use the manifestly conformally invariant description of a Lorentzian conformal structure in terms of a parabolic Cartan geometry in order to introduce a superalgebra structure on the space of twistor spinors and normal conformal vector fields formulated in purely algebraic terms on parallel sections in tractor bundles. Via a fixed metric in the conformal class, one reproduces a conformal superalgebra structure that has been considered in the literature before. The tractor approach, however, makes clear that the failure of this object to be a Lie superalgebra in certain cases is due to purely algebraic identities on the spinor module and to special properties of the conformal holonomy representation. Moreover, it naturally generalizes to higher signatures. This yields new formulas for constructing new twistor spinors and higher order normal conformal Killing forms out of existing ones, generalizing the well-known spinorial Lie derivative. Moreover, we derive restrictions on the possible dimension of the space of twistor spinors in any metric signature. (paper)

  16. Conformance and Deviance

    DEFF Research Database (Denmark)

    Gjerdrum Pedersen, Esben Rahbek; Neergaard, Peter; Thusgaard Pedersen, Janni;

    2013-01-01

    This paper analyses how large Danish companies are responding to new governmental regulation which requires them to report on corporate social responsibility (CSR). The paper is based on an analysis of 142 company annual reports required by the new Danish regulation regarding CSR reporting, plus ...... in CSR reporting practices. Finally, it is argued that non-conformance with the new regulatory requirements is not solely about conscious resistance but may also be caused by, for example, lack of awareness, resource limitations, misinterpretations, and practical difficulties....

  17. Automatic Complexity Analysis

    DEFF Research Database (Denmark)

    Rosendahl, Mads

    1989-01-01

    One way to analyse programs is to to derive expressions for their computational behaviour. A time bound function (or worst-case complexity) gives an upper bound for the computation time as a function of the size of input. We describe a system to derive such time bounds automatically using abstract...

  18. Conformally symmetric traversable wormholes

    International Nuclear Information System (INIS)

    Exact solutions of traversable wormholes are found under the assumption of spherical symmetry and the existence of a nonstatic conformal symmetry, which presents a more systematic approach in searching for exact wormhole solutions. In this work, a wide variety of solutions are deduced by considering choices for the form function, a specific linear equation of state relating the energy density and the pressure anisotropy, and various phantom wormhole geometries are explored. A large class of solutions impose that the spatial distribution of the exotic matter is restricted to the throat neighborhood, with a cutoff of the stress-energy tensor at a finite junction interface, although asymptotically flat exact solutions are also found. Using the 'volume integral quantifier', it is found that the conformally symmetric phantom wormhole geometries may, in principle, be constructed by infinitesimally small amounts of averaged null energy condition violating matter. Considering the tidal acceleration traversability conditions for the phantom wormhole geometry, specific wormhole dimensions and the traversal velocity are also deduced

  19. INFRARED SPECTROSCOPIC CHARACTERIZATION OF CONFORMATIONAL DEFECTS OF POLYBENZAMIDE

    Institute of Scientific and Technical Information of China (English)

    YANG Xiaozhen

    1991-01-01

    Theoretical results of normal coordinate analysis of polybenzamide performed with two conformational isomerized models, the cis-trans and the all-trans conformation, have been adopted to examine a number of infrared spectra of films of the polymer treated in a subsequent annealing process and a cooling process. It shows, in this investigation, that two sets of infrared spectral profiles around 1400 cm-1 and 900 cm-1 behave quite attractively. Their spectral behaviours have been correlated to the conformational defect variation in samples, and reasonably predicted by the normal coordinate calculation.

  20. Conformational Preferences in Small Peptide Models: The Relevance of cis/trans-Conformations.

    Science.gov (United States)

    Jangra, Harish; Haindl, Michael H; Achrainer, Florian; Hioe, Johnny; Gschwind, Ruth M; Zipse, Hendrik

    2016-09-01

    The accurate description of cis/trans peptide structures is of fundamental relevance for the field of protein modeling and protein structure determination. A comprehensive conformational analysis of dipeptide model Ace-Gly-NMe (1) has been carried out by using a combination of theoretical calculations and experimental ((1) H and (13) C NMR and NOESY) spectroscopic measurements to assess the relevance of cis-peptide conformers. NMR measurements in dimethyl sulfoxide (DMSO) solution and calculations employing a continuum solvation model both point to the extended trans,trans conformer C5_tt as the global minimum. The cis-peptide structures C5_ct and C5_tc, with the N- or C-terminal amide group in cis-conformation, are observed separately and located 13.0±2 kJ mol(-1) higher in energy. This is in close agreement with the theoretical prediction of around 12 kJ mol(-1) in DMSO. The ability of common protein force fields to reproduce the energies of the cis-amide conformers C5_ct and C5_tc in 1 is limited, making these methods unsuitable for the description of cis-peptide structures in protein simulations. PMID:27535479

  1. Fermion-Scalar Conformal Blocks

    CERN Document Server

    Iliesiu, Luca; Poland, David; Pufu, Silviu S; Simmons-Duffin, David; Yacoby, Ran

    2015-01-01

    We compute the conformal blocks associated with scalar-scalar-fermion-fermion 4-point functions in 3D CFTs. Together with the known scalar conformal blocks, our result completes the task of determining the so-called `seed blocks' in three dimensions. Conformal blocks associated with 4-point functions of operators with arbitrary spins can now be determined from these seed blocks by using known differential operators.

  2. Subtleties Concerning Conformal Tractor Bundles

    CERN Document Server

    Graham, C Robin

    2012-01-01

    The realization of tractor bundles as associated bundles in conformal geometry is studied. It is shown that different natural choices of principal bundle with normal Cartan connection corresponding to a given conformal manifold can give rise to topologically distinct associated tractor bundles for the same inducing representation. Consequences for homogeneous models and conformal holonomy are described. A careful presentation is made of background material concerning standard tractor bundles and equivalence between parabolic geometries and underlying structures.

  3. Einstein Gravity from Conformal Gravity

    OpenAIRE

    Maldacena, Juan

    2011-01-01

    We show that that four dimensional conformal gravity plus a simple Neumann boundary condition can be used to get the semiclassical (or tree level) wavefunction of the universe of four dimensional asymptotically de-Sitter or Euclidean anti-de Sitter spacetimes. This simple Neumann boundary condition selects the Einstein solution out of the more numerous solutions of conformal gravity. It thus removes the ghosts of conformal gravity from this computation. In the case of a five dimensional pure ...

  4. Coends in conformal field theory

    CERN Document Server

    Fuchs, Jürgen

    2016-01-01

    The idea of "summing over all intermediate states" that is central for implementing locality in quantum systems can be realized by coend constructions. In the concrete case of systems of conformal blocks for a certain class of conformal vertex algebras, one deals with coends in functor categories. Working with these coends involves quite a few subtleties which, even though they have in principle already been understood twenty years ago, have not been sufficiently appreciated by the conformal field theory community.

  5. Dimensional Reduction for Conformal Blocks

    CERN Document Server

    Hogervorst, Matthijs

    2016-01-01

    We consider the dimensional reduction of a CFT, breaking multiplets of the d-dimensional conformal group SO(d+1,1) up into multiplets of SO(d,1). This leads to an expansion of d-dimensional conformal blocks in terms of blocks in d-1 dimensions. In particular, we obtain a formula for 3d conformal blocks as an infinite sum over 2F1 hypergeometric functions with closed-form coefficients.

  6. Fully Automatic Expression-Invariant Face Correspondence

    CERN Document Server

    Salazar, Augusto; Shu, Chang; Prieto, Flavio

    2012-01-01

    We consider the problem of computing accurate point-to-point correspondences among a set of human face scans with varying expressions. Our fully automatic approach does not require any manually placed markers on the scan. Instead, the approach learns the locations of a set of landmarks present in a database and uses this knowledge to automatically predict the locations of these landmarks on a newly available scan. The predicted landmarks are then used to compute point-to-point correspondences between a template model and the newly available scan. To accurately fit the expression of the template to the expression of the scan, we use as template a blendshape model. Our algorithm was tested on a database of human faces of different ethnic groups with strongly varying expressions. Experimental results show that the obtained point-to-point correspondence is both highly accurate and consistent for most of the tested 3D face models.

  7. Reflections on Conformal Spectra

    CERN Document Server

    Kim, Hyungrok; Ooguri, Hirosi

    2015-01-01

    We use modular invariance and crossing symmetry of conformal field theory to reveal approximate reflection symmetries in the spectral decompositions of the partition function in two dimensions in the limit of large central charge and of the four-point function in any dimension in the limit of large scaling dimensions $\\Delta_0$ of external operators. We use these symmetries to motivate universal upper bounds on the spectrum and the operator product expansion coefficients, which we then derive by independent techniques. Some of the bounds for four-point functions are valid for finite $\\Delta_0$ as well as for large $\\Delta_0$. We discuss a similar symmetry in a large spacetime dimension limit. Finally, we comment on the analogue of the Cardy formula and sparse light spectrum condition for the four-point function.

  8. Reflections on Conformal Spectra

    CERN Document Server

    CERN. Geneva

    2015-01-01

    We use modular invariance and crossing symmetry of conformal field theory to reveal approximate reflection symmetries in the spectral decompositions of the partition function in two dimensions in the limit of large central charge and of the four-point function in any dimension in the limit of large scaling dimensions Δ0 of external operators. We use these symmetries to motivate universal upper bounds on the spectrum and the operator product expansion coefficients, which we then derive by independent techniques. Some of the bounds for four-point functions are valid for finite Δ0 as well as for large Δ0. We discuss a similar symmetry in a large spacetime dimension limit. Finally, we comment on the analogue of the Cardy formula and sparse light spectrum condition for the four-point function. (based on 1510.08772 with Kim & Ooguri). This seminar will be given via videolink

  9. Conformal Spectrum and Harmonic maps

    CERN Document Server

    Nadirashvili, Nikolai

    2010-01-01

    This paper is devoted to the study of the conformal spectrum (and more precisely the first eigenvalue) of the Laplace-Beltrami operator on a smooth connected compact Riemannian surface without boundary, endowed with a conformal class. We give a constructive proof of a critical metric which is smooth except at some conical singularities and maximizes the first eigenvalue in the conformal class of the background metric. We also prove that the map associating a finite number of eigenvectors of the maximizing $\\lambda_1$ into the sphere is harmonic, establishing a link between conformal spectrum and harmonic maps.

  10. Loop Virasoro Lie conformal algebra

    Energy Technology Data Exchange (ETDEWEB)

    Wu, Henan, E-mail: wuhenanby@163.com; Chen, Qiufan; Yue, Xiaoqing [Department of Mathematics, Tongji University, Shanghai 200092 (China)

    2014-01-15

    The Lie conformal algebra of loop Virasoro algebra, denoted by CW, is introduced in this paper. Explicitly, CW is a Lie conformal algebra with C[∂]-basis (L{sub i} | i∈Z) and λ-brackets [L{sub i} {sub λ} L{sub j}] = (−∂−2λ)L{sub i+j}. Then conformal derivations of CW are determined. Finally, rank one conformal modules and Z-graded free intermediate series modules over CW are classified.

  11. Crude unit automatic crude switch control using. Multivariable predictive control technology; Joatsu joryu sochi no gen`yu kirikae jidoka. Tahensu seigyo to kisetsu seigyo system ni yoru saiteki unten

    Energy Technology Data Exchange (ETDEWEB)

    Ageishi, N. [Yamatake-Honeywell Co. Ltd., Tokyo (Japan)

    1998-06-01

    This paper describes automatic crude oil switching control for normal pressure distilling equipment used in oil refineries. Crude oil has been switched several times a week, where an operator has made adjustment manually at each time of the switching. Operation frequency was high, much labor was required, and loss was produced due to excess quality. The present attempt has realized an optimum operation by introducing multivariable crude oil switching technology and combining it with the existing advanced control technology. Because the realized technology automatically detects the crude oil switching which does not require input of yield data of crude oil to be processed based on a production plan, there is no need of TBP slope estimation, and control mode switching by an operator based thereon, or feed-forward by using data of crude oil nature. The technology is also capable of dealing with crude oil switching having large yield variation. Operating conditions are adjusted automatically based on the nature estimation, hence no manual adjustment is required. Loss due to excess quality can be minimized. Time to adjust the switching can be decreased. Effectiveness of this system was verified in a wide range from normal operation to unsteady state in crude oil switching. 3 refs., 6 figs., 2 tabs.

  12. Automatic trend estimation

    CERN Document Server

    Vamos¸, C˘alin

    2013-01-01

    Our book introduces a method to evaluate the accuracy of trend estimation algorithms under conditions similar to those encountered in real time series processing. This method is based on Monte Carlo experiments with artificial time series numerically generated by an original algorithm. The second part of the book contains several automatic algorithms for trend estimation and time series partitioning. The source codes of the computer programs implementing these original automatic algorithms are given in the appendix and will be freely available on the web. The book contains clear statement of the conditions and the approximations under which the algorithms work, as well as the proper interpretation of their results. We illustrate the functioning of the analyzed algorithms by processing time series from astrophysics, finance, biophysics, and paleoclimatology. The numerical experiment method extensively used in our book is already in common use in computational and statistical physics.

  13. The pseudo-conformal universe: scale invariance from spontaneous breaking of conformal symmetry

    International Nuclear Information System (INIS)

    We present a novel theory of the very early universe which addresses the traditional horizon and flatness problems of big bang cosmology and predicts a scale invariant spectrum of perturbations. Unlike inflation, this scenario requires no exponential accelerated expansion of space-time. Instead, the early universe is described by a conformal field theory minimally coupled to gravity. The conformal fields develop a time-dependent expectation value which breaks the flat space so(4,2) conformal symmetry down to so(4,1), the symmetries of de Sitter, giving perturbations a scale invariant spectrum. The solution is an attractor, at least in the case of a single time-dependent field. Meanwhile, the metric background remains approximately flat but slowly contracts, which makes the universe increasingly flat, homogeneous and isotropic, akin to the smoothing mechanism of ekpyrotic cosmology. Our scenario is very general, requiring only a conformal field theory capable of developing the appropriate time-dependent expectation values, and encompasses existing incarnations of this idea, specifically the U(1) model of Rubakov and the Galileon Genesis scenario. Its essential features depend only on the symmetry breaking pattern and not on the details of the underlying lagrangian. It makes generic observational predictions that make it potentially distinguishable from standard inflation, in particular significant non-gaussianities and the absence of primordial gravitational waves

  14. Automatic Program Reports

    OpenAIRE

    Lígia Maria da Silva Ribeiro; Gabriel de Sousa Torcato David

    2007-01-01

    To profit from the data collected by the SIGARRA academic IS, a systematic setof graphs and statistics has been added to it and are available on-line. Thisanalytic information can be automatically included in a flexible yearly report foreach program as well as in a synthesis report for the whole school. Somedifficulties in the interpretation of some graphs led to the definition of new keyindicators and the development of a data warehouse across the university whereeffective data consolidation...

  15. Automatic food decisions

    DEFF Research Database (Denmark)

    Mueller Loose, Simone

    Consumers' food decisions are to a large extent shaped by automatic processes, which are either internally directed through learned habits and routines or externally influenced by context factors and visual information triggers. Innovative research methods such as eye tracking, choice experiments...... and food diaries allow us to better understand the impact of unconscious processes on consumers' food choices. Simone Mueller Loose will provide an overview of recent research insights into the effects of habit and context on consumers' food choices....

  16. Automatic Differentiation Variational Inference

    OpenAIRE

    Kucukelbir, Alp; Tran, Dustin; Ranganath, Rajesh; Gelman, Andrew; Blei, David M.

    2016-01-01

    Probabilistic modeling is iterative. A scientist posits a simple model, fits it to her data, refines it according to her analysis, and repeats. However, fitting complex models to large data is a bottleneck in this process. Deriving algorithms for new models can be both mathematically and computationally challenging, which makes it difficult to efficiently cycle through the steps. To this end, we develop automatic differentiation variational inference (ADVI). Using our method, the scientist on...

  17. SIMS: a hybrid method for rapid conformational analysis.

    Directory of Open Access Journals (Sweden)

    Bryant Gipson

    Full Text Available Proteins are at the root of many biological functions, often performing complex tasks as the result of large changes in their structure. Describing the exact details of these conformational changes, however, remains a central challenge for computational biology due the enormous computational requirements of the problem. This has engendered the development of a rich variety of useful methods designed to answer specific questions at different levels of spatial, temporal, and energetic resolution. These methods fall largely into two classes: physically accurate, but computationally demanding methods and fast, approximate methods. We introduce here a new hybrid modeling tool, the Structured Intuitive Move Selector (sims, designed to bridge the divide between these two classes, while allowing the benefits of both to be seamlessly integrated into a single framework. This is achieved by applying a modern motion planning algorithm, borrowed from the field of robotics, in tandem with a well-established protein modeling library. sims can combine precise energy calculations with approximate or specialized conformational sampling routines to produce rapid, yet accurate, analysis of the large-scale conformational variability of protein systems. Several key advancements are shown, including the abstract use of generically defined moves (conformational sampling methods and an expansive probabilistic conformational exploration. We present three example problems that sims is applied to and demonstrate a rapid solution for each. These include the automatic determination of "active" residues for the hinge-based system Cyanovirin-N, exploring conformational changes involving long-range coordinated motion between non-sequential residues in Ribose-Binding Protein, and the rapid discovery of a transient conformational state of Maltose-Binding Protein, previously only determined by Molecular Dynamics. For all cases we provide energetic validations using well

  18. Replacement between conformity and counter-conformity in consumption decisions.

    Science.gov (United States)

    Chou, Ting-Jui; Chang, En-Chung; Dai, Qi; Wong, Veronica

    2013-02-01

    This study assessed, in a Chinese context, how self-esteem interacts with perceived similarity and uniqueness to yield cognitive dissonance, and whether the dissonance leads to self-reported conformity or counter-conformity behavior. Participants were 408 respondents from 4 major Chinese cities (M age = 33.0 yr., SD = 4.3; 48% men). Self-perceptions of uniqueness, similarity, cognitive dissonance, self-esteem and need to behave in conformity or counter-conformity were measured. A theoretical model was assessed in four situations, relating the ratings of self-esteem and perceived similarity/uniqueness to the way other people at a wedding were dressed, and the resultant cognitive dissonance and conformity/ counter-conformity behavior. Regardless of high or low self-esteem, all participants reported cognitive dissonance when they were told that they were dressed extremely similarly to or extremely differently from the other people attending the wedding. However, the conforming/counter-conforming strategies used by participants to resolve the cognitive dissonance differed. When encountering dissonance induced by the perceived extreme uniqueness of dress, participants with low self-esteem tended to say they would dress next time so as to conform with the way others were dressed, while those with high self-esteem indicated they would continue their counter-conformity in attire. When encountering dissonance induced by the perceived extreme similarity to others, both those with high and low self-esteem tended to say they would dress in an unorthodox manner to surprise other people in the future. PMID:23654033

  19. Replacement between conformity and counter-conformity in consumption decisions.

    Science.gov (United States)

    Chou, Ting-Jui; Chang, En-Chung; Dai, Qi; Wong, Veronica

    2013-02-01

    This study assessed, in a Chinese context, how self-esteem interacts with perceived similarity and uniqueness to yield cognitive dissonance, and whether the dissonance leads to self-reported conformity or counter-conformity behavior. Participants were 408 respondents from 4 major Chinese cities (M age = 33.0 yr., SD = 4.3; 48% men). Self-perceptions of uniqueness, similarity, cognitive dissonance, self-esteem and need to behave in conformity or counter-conformity were measured. A theoretical model was assessed in four situations, relating the ratings of self-esteem and perceived similarity/uniqueness to the way other people at a wedding were dressed, and the resultant cognitive dissonance and conformity/ counter-conformity behavior. Regardless of high or low self-esteem, all participants reported cognitive dissonance when they were told that they were dressed extremely similarly to or extremely differently from the other people attending the wedding. However, the conforming/counter-conforming strategies used by participants to resolve the cognitive dissonance differed. When encountering dissonance induced by the perceived extreme uniqueness of dress, participants with low self-esteem tended to say they would dress next time so as to conform with the way others were dressed, while those with high self-esteem indicated they would continue their counter-conformity in attire. When encountering dissonance induced by the perceived extreme similarity to others, both those with high and low self-esteem tended to say they would dress in an unorthodox manner to surprise other people in the future.

  20. Automatically Discovering Hidden Transformation Chaining Constraints

    CERN Document Server

    Chenouard, Raphael; 10.1007/978-3-642-04425-0_8

    2010-01-01

    Model transformations operate on models conforming to precisely defined metamodels. Consequently, it often seems relatively easy to chain them: the output of a transformation may be given as input to a second one if metamodels match. However, this simple rule has some obvious limitations. For instance, a transformation may only use a subset of a metamodel. Therefore, chaining transformations appropriately requires more information. We present here an approach that automatically discovers more detailed information about actual chaining constraints by statically analyzing transformations. The objective is to provide developers who decide to chain transformations with more data on which to base their choices. This approach has been successfully applied to the case of a library of endogenous transformations. They all have the same source and target metamodel but have some hidden chaining constraints. In such a case, the simple metamodel matching rule given above does not provide any useful information.

  1. Counselor Identity: Conformity or Distinction?

    Science.gov (United States)

    McLaughlin, Jerry E.; Boettcher, Kathryn

    2009-01-01

    The authors explore 3 debates in other disciplines similar to counseling's identity debate in order to learn about common themes and outcomes. Conformity, distinction, and cohesion emerged as common themes. They conclude that counselors should retain their distinctive, humanistic approach rather than conforming to the dominant, medical approach.

  2. Classical Virasoro irregular conformal block

    CERN Document Server

    Rim, Chaiho

    2015-01-01

    Virasoro irregular conformal block with arbitrary rank is obtained for the classical limit or equivalently Nekrasov-Shatashvili limit using the beta-deformed irregular matrix model (Penner-type matrix model for the irregular conformal block). The same result is derived using the generalized Mathieu equation which is equivalent to the loop equation of the irregular matrix model.

  3. Investigating the Relationship between Stable Personality Characteristics and Automatic Imitation.

    Directory of Open Access Journals (Sweden)

    Emily E Butler

    Full Text Available Automatic imitation is a cornerstone of nonverbal communication that fosters rapport between interaction partners. Recent research has suggested that stable dimensions of personality are antecedents to automatic imitation, but the empirical evidence linking imitation with personality traits is restricted to a few studies with modest sample sizes. Additionally, atypical imitation has been documented in autism spectrum disorders and schizophrenia, but the mechanisms underpinning these behavioural profiles remain unclear. Using a larger sample than prior studies (N=243, the current study tested whether performance on a computer-based automatic imitation task could be predicted by personality traits associated with social behaviour (extraversion and agreeableness and with disorders of social cognition (autistic-like and schizotypal traits. Further personality traits (narcissism and empathy were assessed in a subsample of participants (N=57. Multiple regression analyses showed that personality measures did not predict automatic imitation. In addition, using a similar analytical approach to prior studies, no differences in imitation performance emerged when only the highest and lowest 20 participants on each trait variable were compared. These data weaken support for the view that stable personality traits are antecedents to automatic imitation and that neural mechanisms thought to support automatic imitation, such as the mirror neuron system, are dysfunctional in autism spectrum disorders or schizophrenia. In sum, the impact that personality variables have on automatic imitation is less universal than initial reports suggest.

  4. Towards conformal loop quantum gravity

    CERN Document Server

    Wang, C H T

    2006-01-01

    A discussion is given of recent developments in canonical gravity that assimilates the conformal analysis of gravitational degrees of freedom. The work is motivated by the problem of time in quantum gravity and is carried out at the metric and the triad levels. At the metric level, it is shown that by extending the Arnowitt-Deser-Misner (ADM) phase space of general relativity (GR), a conformal form of geometrodynamics can be constructed. In addition to the Hamiltonian and diffeomorphism constraints, an extra first class constraint is introduced to generate conformal transformations. This phase space consists of York's mean extrinsic curvature time, conformal three-metric and their momenta. At the triad level, the phase space of GR is further enlarged by incorporating spin-gauge as well as conformal symmetries. This leads to a canonical formulation of GR using a new set of real spin connection variables. The resulting gravitational constraints are first class, consisting of the Hamiltonian constraint and the c...

  5. Projectors, Shadows, and Conformal Blocks

    CERN Document Server

    Simmons-Duffin, David

    2012-01-01

    We introduce a method for computing conformal blocks of operators in arbitrary Lorentz representations in any spacetime dimension, making it possible to apply bootstrap techniques to operators with spin. The key idea is to implement the "shadow formalism" of Ferrara, Gatto, Grillo, and Parisi in a setting where conformal invariance is manifest. Conformal blocks in d-dimensions can be expressed as integrals over the projective null-cone in the "embedding space" R^{d+1,1}. Taking care with their analytic structure, these integrals can be evaluated in great generality, reducing the computation of conformal blocks to a bookkeeping exercise. To facilitate calculations in four-dimensional CFTs, we introduce techniques for writing down conformally-invariant correlators using auxiliary twistor variables, and demonstrate their use in some simple examples.

  6. Recursion Relations for Conformal Blocks

    CERN Document Server

    Penedones, João; Yamazaki, Masahito

    2015-01-01

    In the context of conformal field theories in general space-time dimension, we find all the possible singularities of the conformal blocks as functions of the scaling dimension $\\Delta$ of the exchanged operator. In particular, we argue, using representation theory of parabolic Verma modules, that in odd spacetime dimension the singularities are only simple poles. We discuss how to use this information to write recursion relations that determine the conformal blocks. We first recover the recursion relation introduced in 1307.6856 for conformal blocks of external scalar operators. We then generalize this recursion relation for the conformal blocks associated to the four point function of three scalar and one vector operator. Finally we specialize to the case in which the vector operator is a conserved current.

  7. Exposure to violent video games increases automatic aggressiveness.

    Science.gov (United States)

    Uhlmann, Eric; Swanson, Jane

    2004-02-01

    The effects of exposure to violent video games on automatic associations with the self were investigated in a sample of 121 students. Playing the violent video game Doom led participants to associate themselves with aggressive traits and actions on the Implicit Association Test. In addition, self-reported prior exposure to violent video games predicted automatic aggressive self-concept, above and beyond self-reported aggression. Results suggest that playing violent video games can lead to the automatic learning of aggressive self-views. PMID:15013259

  8. The Conformal Standard Model

    CERN Document Server

    Latosinski, Adam; Meissner, Krzysztof A; Nicolai, Hermann

    2015-01-01

    We present an extended version of the Conformal Standard Model (characterized by the absence of any new intermediate scales between the electroweak scale and the Planck scale) with an enlarged scalar sector coupling to right-chiral neutrinos in such a way that the scalar potential and the Yukawa couplings involving only right-chiral neutrinos are invariant under a new global symmetry SU(3)$_N$ which is broken explicitly only by the Yukawa interaction coupling right-chiral neutrinos and the electroweak lepton doublets. We point out four main advantages of such an enlargement, namely: (1) the economy of the (non-supersymmetric) Standard Model, and thus its observational success, is preserved; (2) thanks to the enlarged scalar sector the RG improved one-loop effective potential is everywhere positive with a stable global minimum, thereby avoiding the notorious instability of the Standard Model vacuum; (3) the pseudo-Goldstone bosons resulting from spontaneous breaking of the SU(3)$_N$ symmetry are natural Dark M...

  9. Imaging of conformational changes

    Energy Technology Data Exchange (ETDEWEB)

    Michl, Josef [Univ. of Colorado, Boulder, CO (United States)

    2016-03-13

    Control of intramolecular conformational change in a small number of molecules or even a single one by an application of an outside electric field defined by potentials on nearby metal or dielectric surfaces has potential applications in both 3-D and 2-D nanotechnology. Specifically, the synthesis, characterization, and understanding of designed solids with controlled built-in internal rotational motion of a dipole promises a new class of materials with intrinsic dielectric, ferroelectric, optical and optoelectronic properties not found in nature. Controlled rotational motion is of great interest due to its expected utility in phenomena as diverse as transport, current flow in molecular junctions, diffusion in microfluidic channels, and rotary motion in molecular machines. A direct time-resolved observation of the dynamics of motion on ps or ns time scale in a single molecule would be highly interesting but is also very difficult and has yet to be accomplished. Much can be learned from an easier but still challenging comparison of directly observed initial and final orientational states of a single molecule, which is the basis of this project. The project also impacts the understanding of surface-enhanced Raman spectroscopy (SERS) and single-molecule spectroscopic detection, as well as the synthesis of solid-state materials with tailored properties from designed precursors.

  10. Conformational Dynamics of Insulin

    Directory of Open Access Journals (Sweden)

    Qing-xin eHua

    2011-10-01

    Full Text Available We have exploited a prandial insulin analogue (insulin lispro, the active component of Humalog®; Eli Lilly and Co. to elucidate the underlying structure and dynamics of insulin as a monomer in solution. Whereas NMR-based modeling recapitulates structural relationships of insulin crystals (T-state protomers, dynamic anomalies are revealed by amide-proton exchange kinetics in D2O. Surprisingly, the majority of hydrogen bonds observed in crystal structures are only transiently maintained in solution, including key T-state-specific inter-chain contacts. Long-lived hydrogen bonds (as defined by global exchange kinetics exist only at a subset of four -helical sites (two per chain flanking an internal disulfide bridge (cystine A20-B19; these sites map within the proposed folding nucleus of proinsulin. The anomalous flexibility of insulin otherwise spans its active surface and may facilitate receptor binding. Because conformational fluctuations promote the degradation of pharmaceutical formulations, we envisage that dynamic re-engineering of insulin may enable design of ultra-stable formulations for humanitarian use in the developing world.

  11. Regular Submanifolds in Conformal Space Qnp

    Institute of Scientific and Technical Information of China (English)

    Changxiong NIE; Chuanxi WU

    2012-01-01

    The authors study the regular submanifolds in the conformal space Qnp and introduce the submanifold theory in the conformal space Qnp.The first variation formula of the Willmore volume functional of pseudo-Riemannian submanifolds in the conformal space Qnp is given.Finally,the conformal isotropic submanifolds in the conformal space Qnp are classified.

  12. Conformational analysis of phloroglucinols from hypericum Brasiliense by using x-ray diffraction and molecular modeling

    Energy Technology Data Exchange (ETDEWEB)

    Leal, Katia Z.; Lindgren, Eric B.; Correa, Arthur L., E-mail: kzleal@uol.com.b [Universidade Federal Fluminense (UFF), Niteroi, RJ (Brazil). Inst. de Quimica. Dept. de Fisico-Quimica; Yoneda, Julliane D. [Universidade Federal Fluminense (UFF), Volta Redonda, RJ (Brazil). Polo Universitario de Volta Redonda; Pinheiro, Carlos B. [Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG (Brazil). Dept. de Fisica; Franca, Hildegardo S. [Universidade Federal Fluminense (UFF), Niteroi, RJ (Brazil). Faculdade de Farmacia. Dept. de Tecnologia Farmaceutica

    2010-07-01

    In this work we intend to verify the applicability of a computational methodology to predict structural features of organic compounds with biological activity. We selected three phloroglucinols and compared their calculated conformational data with their X-ray crystallographic structure. The results showed that conformations obtained by conformational analysis with the AM1 method followed by geometry optimization by using the DFT B3LYP/6-31 G(d,p) basis set are in very good agreement with X-ray data, indicating that the methodology employed here seems to be a very useful tool in order to predict the conformational preference for this class of compounds. (author)

  13. Automatic Configuration in NTP

    Institute of Scientific and Technical Information of China (English)

    Jiang Zongli(蒋宗礼); Xu Binbin

    2003-01-01

    NTP is nowadays the most widely used distributed network time protocol, which aims at synchronizing the clocks of computers in a network and keeping the accuracy and validation of the time information which is transmitted in the network. Without automatic configuration mechanism, the stability and flexibility of the synchronization network built upon NTP protocol are not satisfying. P2P's resource discovery mechanism is used to look for time sources in a synchronization network, and according to the network environment and node's quality, the synchronization network is constructed dynamically.

  14. Conformal bootstrap with slightly broken higher spin symmetry

    Science.gov (United States)

    Alday, Luis F.; Zhiboedov, Alexander

    2016-06-01

    We consider conformal field theories with slightly broken higher spin symmetry in arbitrary spacetime dimensions. We analyze the crossing equation in the double light-cone limit and solve for the anomalous dimensions of higher spin currents γ s with large spin s. The result depends on the symmetries and the spectrum of the unperturbed conformal field theory. We reproduce all known results and make further predictions. In particular we make a prediction for the anomalous dimensions of higher spin currents in the 3d Ising model.

  15. MARZ: Manual and Automatic Redshifting Software

    CERN Document Server

    Hinton, Samuel R; Lidman, Chris; Glazebrook, Karl; Lewis, Geraint F

    2016-01-01

    The Australian Dark Energy Survey (OzDES) is a 100-night spectroscopic survey underway on the Anglo-Australian Telescope using the fibre-fed 2-degree-field (2dF) spectrograph. We have developed a new redshifting application Marz with greater usability, flexibility, and the capacity to analyse a wider range of object types than the Runz software package previously used for redshifting spectra from 2dF. Marz is an open-source, client-based, Javascript web-application which provides an intuitive interface and powerful automatic matching capabilities on spectra generated from the AAOmega spectrograph to produce high quality spectroscopic redshift measurements. The software can be run interactively or via the command line, and is easily adaptable to other instruments and pipelines if conforming to the current FITS file standard is not possible. Behind the scenes, a modified version of the Autoz cross-correlation algorithm is used to match input spectra against a variety of stellar and galaxy templates, and automat...

  16. Towards conformal loop quantum gravity

    Science.gov (United States)

    H-T Wang, Charles

    2006-03-01

    A discussion is given of recent developments in canonical gravity that assimilates the conformal analysis of gravitational degrees of freedom. The work is motivated by the problem of time in quantum gravity and is carried out at the metric and the triad levels. At the metric level, it is shown that by extending the Arnowitt-Deser-Misner (ADM) phase space of general relativity (GR), a conformal form of geometrodynamics can be constructed. In addition to the Hamiltonian and Diffeomorphism constraints, an extra first class constraint is introduced to generate conformal transformations. This phase space consists of York's mean extrinsic curvature time, conformal three-metric and their momenta. At the triad level, the phase space of GR is further enlarged by incorporating spin-gauge as well as conformal symmetries. This leads to a canonical formulation of GR using a new set of real spin connection variables. The resulting gravitational constraints are first class, consisting of the Hamiltonian constraint and the canonical generators for spin-gauge and conformorphism transformations. The formulation has a remarkable feature of being parameter-free. Indeed, it is shown that a conformal parameter of the Barbero-Immirzi type can be absorbed by the conformal symmetry of the extended phase space. This gives rise to an alternative approach to loop quantum gravity that addresses both the conceptual problem of time and the technical problem of functional calculus in quantum gravity.

  17. Towards conformal loop quantum gravity

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Charles H-T [School of Engineering and Physical Sciences, University of Aberdeen, King' s College, Aberdeen AB24 3UE (United Kingdom); Space Science and Technology Department, Rutherford Appleton Laboratory, Didcot, Oxon OX11 0QX (United Kingdom)

    2006-03-01

    A discussion is given of recent developments in canonical gravity that assimilates the conformal analysis of gravitational degrees of freedom. The work is motivated by the problem of time in quantum gravity and is carried out at the metric and the triad levels. At the metric level, it is shown that by extending the Arnowitt-Deser-Misner (ADM) phase space of general relativity (GR), a conformal form of geometrodynamics can be constructed. In addition to the Hamiltonian and Diffeomorphism constraints, an extra first class constraint is introduced to generate conformal transformations. This phase space consists of York's mean extrinsic curvature time, conformal three-metric and their momenta. At the triad level, the phase space of GR is further enlarged by incorporating spin-gauge as well as conformal symmetries. This leads to a canonical formulation of GR using a new set of real spin connection variables. The resulting gravitational constraints are first class, consisting of the Hamiltonian constraint and the canonical generators for spin-gauge and conformorphism transformations. The formulation has a remarkable feature of being parameter-free. Indeed, it is shown that a conformal parameter of the Barbero-Immirzi type can be absorbed by the conformal symmetry of the extended phase space. This gives rise to an alternative approach to loop quantum gravity that addresses both the conceptual problem of time and the technical problem of functional calculus in quantum gravity.

  18. Locally conformal symplectic manifolds

    Directory of Open Access Journals (Sweden)

    Izu Vaisman

    1985-01-01

    Full Text Available A locally conformal symplectic (l. c. s. manifold is a pair (M2n,Ω where M2n(n>1 is a connected differentiable manifold, and Ω a nondegenerate 2-form on M such that M=⋃αUα (Uα- open subsets. Ω/Uα=eσαΩα, σα:Uα→ℝ, dΩα=0. Equivalently, dΩ=ω∧Ω for some closed 1-form ω. L. c. s. manifolds can be seen as generalized phase spaces of Hamiltonian dynamical systems since the form of the Hamilton equations is, in fact, preserved by homothetic canonical transformations. The paper discusses first Hamiltonian vector fields, and infinitesimal automorphisms (i. a. on l. c. s. manifolds. If (M,Ω has an i. a. X such that ω(X≠0, we say that M is of the first kind and Ω assumes the particular form Ω=dθ−ω∧θ. Such an M is a 2-contact manifold with the structure forms (ω,θ, and it has a vertical 2-dimensional foliation V. If V is regular, we can give a fibration theorem which shows that M is a T2-principal bundle over a symplectic manifold. Particularly, V is regular for some homogeneous l. c. s, manifolds, and this leads to a general construction of compact homogeneous l. c. s, manifolds. Various related geometric results, including reductivity theorems for Lie algebras of i. a. are also given. Most of the proofs are adaptations of corresponding proofs in symplectic and contact geometry. The paper ends with an Appendix which states an analogous fibration theorem in Riemannian geometry.

  19. On the Physical Origin of Galactic Conformity

    CERN Document Server

    Hearin, Andrew P; Bosch, Frank C van den

    2015-01-01

    Correlations between the star formation rates (SFRs) of nearby galaxies (so-called galactic conformity) have been observed for projected separations up to 4 Mpc, an effect not predicted by current semi-analytic models. We investigate correlations between the mass accretion rates (dMvir/dt) of nearby halos as a potential physical origin for this effect. We find that pairs of host halos "know about" each others' assembly histories even when their present-day separation is greater than thirty times the virial radius of either halo. These distances are far too large for direct interaction between the halos to explain the correlation in their dMvir/dt. Instead, halo pairs at these distances reside in the same large-scale tidal environment, which regulates dMvir/dt for both halos. Larger halos are less affected by external forces, which naturally gives rise to a mass dependence of the halo conformity signal. SDSS measurements of galactic conformity exhibit a qualitatively similar dependence on stellar mass, includi...

  20. Conformal Tensors via Lovelock Gravity

    CERN Document Server

    Kastor, David

    2013-01-01

    Constructs from conformal geometry are important in low dimensional gravity models, while in higher dimensions the higher curvature interactions of Lovelock gravity are similarly prominent. Considering conformal invariance in the context of Lovelock gravity leads to natural, higher-curvature generalizations of the Weyl, Schouten, Cotton and Bach tensors, with properties that straightforwardly extend those of their familiar counterparts. As a first application, we introduce a new set of conformally invariant gravity theories in D=4k dimensions, based on the squares of the higher curvature Weyl tensors.

  1. Conformal Patterson-Walker metrics

    CERN Document Server

    Hammerl, Matthias; Šilhan, Josef; Taghavi-Chabert, Arman; Žádník, Vojtěch

    2016-01-01

    The classical Patterson-Walker construction of a split-signature (pseudo-)Riemannian structure from a given torsion-free affine connection is generalized to a construction of a split-signature conformal structure from a given projective class of connections. A characterization of the induced structures is obtained. We achieve a complete description of Einstein metrics in the conformal class formed by the Patterson-Walker metric. Finally, we describe all symmetries of the conformal Patterson-Walker metric. In both cases we obtain descriptions in terms of geometric data on the original structure.

  2. Automatic personnel contamination monitor

    International Nuclear Information System (INIS)

    United Nuclear Industries, Inc. (UNI) has developed an automatic personnel contamination monitor (APCM), which uniquely combines the design features of both portal and hand and shoe monitors. In addition, this prototype system also has a number of new features, including: micro computer control and readout, nineteen large area gas flow detectors, real-time background compensation, self-checking for system failures, and card reader identification and control. UNI's experience in operating the Hanford N Reactor, located in Richland, Washington, has shown the necessity of automatically monitoring plant personnel for contamination after they have passed through the procedurally controlled radiation zones. This final check ensures that each radiation zone worker has been properly checked before leaving company controlled boundaries. Investigation of the commercially available portal and hand and shoe monitors indicated that they did not have the sensitivity or sophistication required for UNI's application, therefore, a development program was initiated, resulting in the subject monitor. Field testing shows good sensitivity to personnel contamination with the majority of alarms showing contaminants on clothing, face and head areas. In general, the APCM has sensitivity comparable to portal survey instrumentation. The inherit stand-in, walk-on feature of the APCM not only makes it easy to use, but makes it difficult to bypass. (author)

  3. Conformally reducible 2+2 spacetimes

    Energy Technology Data Exchange (ETDEWEB)

    Carot, Jaume [Departament de Fisica, Universitat de les Illes Balears, Cra. Valldemossa km 7.5, E-07071 Palma de Mallorca (Spain); Tupper, Brian O J [Department of Mathematics and Statistics, University of New Brunswick, Fredericton, NB E3B 5A3 (Canada)

    2002-08-07

    Spacetimes which are conformal to 2+2 reducible spacetimes are considered. We classify them according to their conformal algebra, giving in each case explicit expressions for the metric and conformal Killing vectors, and providing physically meaningful examples.

  4. Conformally reducible 2+2 spacetimes

    CERN Document Server

    Carot, J

    2002-01-01

    Spacetimes which are conformal to 2+2 reducible spacetimes are considered. We classify them according to their conformal algebra, giving in each case explicit expressions for the metric and conformal Killing vectors, and providing physically meaningful examples.

  5. Conformation of hindered piperidines: Spectroscopic evidence for contribution of boat conformations

    Indian Academy of Sciences (India)

    A Thangamani; J Jayabharathi; A Manimekalai

    2010-07-01

    High resolution 1H and 13C NMR resonance assignments and conformational assignments were carried out for four (3)-benzyl-(2),(6)-bis(aryl)piperidin-4-ones 1-4 and their four -nitroso-(3)-benzyl-(2),(6)-bis(aryl)piperidin-4-ones 5-8. In addition to conventional 1D NMR methods, 2D shiftcorrelated NMR techniques (1H-1H COSY and 1H-13C COSY) were used for signal assignments. At room temperature the (3)-benzyl-(2),(6)-bis(aryl)piperidin-4-ones 1-4 exist in only one isomeric form whereas their -nitroso derivatives 5-8 exist in two isomeric forms. The preferred conformations of both the isomeric forms of nitrosamines were determined by comparison of the spectral data with those of the corresponding parent amines 1-4 and with the aid of substituent parameters. The results indicate the presence of an equilibrium mixture of boat forms B1 and B2 for Z isomers of 5-8. For the E isomers of 5-8, boat form B1 is predicted to be the major conformer. The piperidin-4-ones 1-4 exist in normal chair conformations with equatorial orientations of all the substituents.

  6. A method of active conformation search based on active and inactive analogues, and its application to allylamine antimycotics

    Institute of Scientific and Technical Information of China (English)

    张万年; 季海涛; 周有骏; 朱杰; 朱驹; 吕加国

    1999-01-01

    A new program ACSBAIA (Active Conformation Search Based on Active and Inactive Analogues) for determination of the active conformations was developed based on the rationales that specific functional groups of active analogues could reach and interact with the active site of target receptor by means of the change of conformations, but that of inactive analogues could not interact with the active site owing to conformational restriction. The program consisted of 4 sub-programs: conformation sampling system, active conformation constraint system, inactive conformation exclusion system, and activity prediction system. Pharmacophoric conformation of allylamine antimycotics was studied by this method. Activities of 2 analogues were predicted and tested. The results suggested that the method was scientific and practical. The application of this method was not restricted by the three-dimensional structural knowledge of target receptor. In the absence of structural information about the receptor, the method was

  7. National Automated Conformity Inspection Process

    Data.gov (United States)

    Department of Transportation — The National Automated Conformity Inspection Process (NACIP) Application is intended to expedite the workflow process as it pertains to the FAA Form 81 0-10 Request...

  8. Some Progress in Conformal Geometry

    Directory of Open Access Journals (Sweden)

    Sun-Yung A. Chang

    2007-12-01

    Full Text Available This is a survey paper of our current research on the theory of partial differential equations in conformal geometry. Our intention is to describe some of our current works in a rather brief and expository fashion. We are not giving a comprehensive survey on the subject and references cited here are not intended to be complete. We introduce a bubble tree structure to study the degeneration of a class of Yamabe metrics on Bach flat manifolds satisfying some global conformal bounds on compact manifolds of dimension 4. As applications, we establish a gap theorem, a finiteness theorem for diffeomorphism type for this class, and diameter bound of the $sigma_2$-metrics in a class of conformal 4-manifolds. For conformally compact Einstein metrics we introduce an eigenfunction compactification. As a consequence we obtain some topological constraints in terms of renormalized volumes.

  9. Conformation Distributions in Adsorbed Proteins.

    Science.gov (United States)

    Meuse, Curtis W.; Hubbard, Joseph B.; Vrettos, John S.; Smith, Jackson R.; Cicerone, Marcus T.

    2007-03-01

    While the structural basis of protein function is well understood in the biopharmaceutical and biotechnology industries, few methods for the characterization and comparison of protein conformation distributions are available. New methods capable of measuring the stability of protein conformations and the integrity of protein-protein, protein-ligand and protein-surface interactions both in solution and on surfaces are needed to help the development of protein-based products. We are developing infrared spectroscopy methods for the characterization and comparison of molecular conformation distributions in monolayers and in solutions. We have extracted an order parameter describing the orientational and conformational variations of protein functional groups around the average molecular values from a single polarized spectrum. We will discuss the development of these methods and compare them to amide hydrogen/deuterium exchange methods for albumin in solution and on different polymer surfaces to show that our order parameter is related to protein stability.

  10. A topological and conformational stability alphabet for multipass membrane proteins.

    Science.gov (United States)

    Feng, Xiang; Barth, Patrick

    2016-03-01

    Multipass membrane proteins perform critical signal transduction and transport across membranes. How transmembrane helix (TMH) sequences encode the topology and conformational flexibility regulating these functions remains poorly understood. Here we describe a comprehensive analysis of the sequence-structure relationships at multiple interacting TMHs from all membrane proteins with structures in the Protein Data Bank (PDB). We found that membrane proteins can be deconstructed in interacting TMH trimer units, which mostly fold into six distinct structural classes of topologies and conformations. Each class is enriched in recurrent sequence motifs from functionally unrelated proteins, revealing unforeseen consensus and evolutionary conserved networks of stabilizing interhelical contacts. Interacting TMHs' topology and local protein conformational flexibility were remarkably well predicted in a blinded fashion from the identified binding-hotspot motifs. Our results reveal universal sequence-structure principles governing the complex anatomy and plasticity of multipass membrane proteins that may guide de novo structure prediction, design, and studies of folding and dynamics. PMID:26780406

  11. Pattern-Driven Automatic Parallelization

    Directory of Open Access Journals (Sweden)

    Christoph W. Kessler

    1996-01-01

    Full Text Available This article describes a knowledge-based system for automatic parallelization of a wide class of sequential numerical codes operating on vectors and dense matrices, and for execution on distributed memory message-passing multiprocessors. Its main feature is a fast and powerful pattern recognition tool that locally identifies frequently occurring computations and programming concepts in the source code. This tool also works for dusty deck codes that have been "encrypted" by former machine-specific code transformations. Successful pattern recognition guides sophisticated code transformations including local algorithm replacement such that the parallelized code need not emerge from the sequential program structure by just parallelizing the loops. It allows access to an expert's knowledge on useful parallel algorithms, available machine-specific library routines, and powerful program transformations. The partially restored program semantics also supports local array alignment, distribution, and redistribution, and allows for faster and more exact prediction of the performance of the parallelized target code than is usually possible.

  12. CONFORMANCE IMPROVEMENT USING GELS

    Energy Technology Data Exchange (ETDEWEB)

    Randall S. Seright

    2003-09-01

    This report describes work performed during the second year of the project, ''Conformance Improvement Using Gels.'' The project has two objectives. The first objective is to identify gel compositions and conditions that substantially reduce flow through fractures that allow direct channeling between wells, while leaving secondary fractures open so that high fluid injection and production rates can be maintained. The second objective is to optimize treatments in fractured production wells, where the gel must reduce permeability to water much more than that to oil. Pore-level images from X-ray computed microtomography were re-examined for Berea sandstone and porous polyethylene. This analysis suggests that oil penetration through gel-filled pores occurs by a gel-dehydration mechanism, rather than a gel-ripping mechanism. This finding helps to explain why aqueous gels can reduce permeability to water more than to oil. We analyzed a Cr(III)-acetate-HPAM gel treatment in a production well in the Arbuckle formation. The availability of accurate pressure data before, during, and after the treatment was critical for the analysis. After the gel treatment, water productivity was fairly constant at about 20% of the pre-treatment value. However, oil productivity was stimulated by a factor of 18 immediately after the treatment. During the six months after the treatment, oil productivity gradually decreased to approach the pre-treatment value. To explain this behavior, we proposed that the fracture area open to oil flow was increased substantially by the gel treatment, followed by a gradual closing of the fractures during subsequent production. For a conventional Cr(III)-acetate-HPAM gel, the delay between gelant preparation and injection into a fracture impacts the placement, leakoff, and permeability reduction behavior. Formulations placed as partially formed gels showed relatively low pressure gradients during placement, and yet substantially reduced the

  13. Variable-mass Thermodynamics Calculation Model for Gas-operated Automatic Weapon%Variable-mass Thermodynamics Calculation Model for Gas-operated Automatic Weapon

    Institute of Scientific and Technical Information of China (English)

    陈建彬; 吕小强

    2011-01-01

    Aiming at the fact that the energy and mass exchange phenomena exist between barrel and gas-operated device of the automatic weapon, for describing its interior ballistics and dynamic characteristics of the gas-operated device accurately, a new variable-mass thermodynamics model is built. It is used to calculate the automatic mechanism velocity of a certain automatic weapon, the calculation results coincide with the experimental results better, and thus the model is validated. The influences of structure parameters on gas-operated device' s dynamic characteristics are discussed. It shows that the model is valuable for design and accurate performance prediction of gas-operated automatic weapon.

  14. Christian Religiosity, Self-Control and Social Conformity

    Science.gov (United States)

    Welch, Michael R.; Tittle, Charles R.; Grasmick, Harold G.

    2006-01-01

    Survey data from a southwestern metropolitan area are used to analyze whether the ability of personal Christian religiosity to predict social conformity is spuriously due to self-control. Results indicate that both personal religiosity and self-control display statistically significant, independent negative net relationships with many forms of…

  15. An SIS model for cultural trait transmission with conformity bias.

    Science.gov (United States)

    Walters, Caroline E; Kendal, Jeremy R

    2013-12-01

    Epidemiological models have been applied to human health-related behaviors that are affected by social interaction. Typically these models have not considered conformity bias, that is, the exaggerated propensity to adopt commonly observed behaviors or opinions, or content biases, where the content of the learned trait affects the probability of adoption. Here we consider an interaction of these two effects, presenting an SIS-type model for the spread and persistence of a behavior which is transmitted via social learning. Uptake is controlled by a nonlinear dependence on the proportion of individuals demonstrating the behavior in a population. Three equilibrium solutions are found, their linear stability is analyzed and the results are compared with a model for unbiased social learning. Our analysis focuses on the effects of the strength of conformity bias and the effects of content biases which alter a conformity threshold frequency of the behavior, above which there is an exaggerated propensity for adoption. The strength of the conformity bias is found to qualitatively alter the predictions regarding whether the trait becomes endemic within the population and the proportion of individuals who display the trait when it is endemic. As the conformity strength increases, the number of feasible equilibrium solutions increases from two to three, leading to a situation where the stable equilibrium attained is dependent upon the initial state. Varying the conformity threshold frequency directionally alters the behavior invasion threshold. Finally we discuss the possible application of this model to binge drinking behavior.

  16. Enthalpy Differences of the n-Pentane Conformers.

    Science.gov (United States)

    Csontos, József; Nagy, Balázs; Gyevi-Nagy, László; Kállay, Mihály; Tasi, Gyula

    2016-06-14

    The energy and enthalpy differences of alkane conformers in various temperature ranges have been the subject for both experimental and theoretical studies over the last few decades. It was shown previously for the conformers of butane [G. Tasi et al., J. Chem. Theory Comput. 2012, 8, 479-486] that quantum chemical results can compete with spectroscopic techniques and results obtained even from the most carefully performed experiments could be biased due to the improper statistical model utilized to evaluate the raw experimental data. In the current study, on one hand, the experimental values and their uncertainties for the enthalpy differences for pentane conformers are re-evaluated using the appropriate statistical model. On the other hand, a coupled-cluster-based focal-point analysis has been performed to calculate energy and enthalpy differences for the conformers of pentane. The model chemistry defined in this study includes contributions up to the perturbative quadruple excitations augmented with further small correction terms beyond the Born-Oppenheimer and nonrelativistic approximations. Benchmark quality energy and enthalpy differences for the pentane conformers are given at temperatures 0 and 298.15 K as well as for the various temperature ranges used in the gas-phase experimental measurements. Furthermore, a slight positive shift for the experimental enthalpy differences is also predicted due to an additional Raman active band belonging to the gauche-gauche conformer.

  17. Conformal Window and Correlation Functions in Lattice Conformal QCD

    CERN Document Server

    Iwasaki, Y

    2012-01-01

    We discuss various aspects of Conformal Field Theories on the Lattice. We investigate the SU(3) gauge theory with Nf fermions in the fundamental representation. First we make a brief review of our previous works on the phase structure of lattice gauge theories in terms of the gauge coupling constant and the quark mass. We thereby clarify the reason why we conjecture that the conformal window is 7 = 1 exhibit the characteristics of the conformal function with IR cutoff, an exponential damping with power correction. Investigating our numerical data by a new method, the "micro-analysis" of propagators, we observe that our data are consistent with the picture that the Nf=7 case and the Nf=2 at T ~ 2Tc case are close to the meson unparticle model. On the other hand, the Nf=16 case and the Nf=2 at T= 10^2 ~10^5 Tc cases are close to the fermion unparticle model.

  18. Conformation and interactions of dopamine hydrochloride in solution

    Energy Technology Data Exchange (ETDEWEB)

    Callear, Samantha K.; Imberti, Silvia [ISIS Facility, STFC Rutherford Appleton Laboratory, Harwell Oxford, Didcot OX11 0QX (United Kingdom); Johnston, Andrew; McLain, Sylvia E. [Biochemistry Department, University of Oxford, South Parks Road, Oxford OX1 3QU (United Kingdom)

    2015-01-07

    The aqueous solution of dopamine hydrochloride has been investigated using neutron and X-ray total scattering data together with Monte-Carlo based modelling using Empirical Potential Structure Refinement. The conformation of the protonated dopamine molecule is presented and the results compared to the conformations found in crystal structures, dopamine-complexed protein crystal structures and predicted from theoretical calculations and pharmacophoric models. It is found that protonated dopamine adopts a range of conformations in solution, highlighting the low rotational energy barrier between different conformations, with the preferred conformation being trans-perpendicular. The interactions between each of the species present (protonated dopamine molecules, water molecules, and chloride anions) have been determined and are discussed with reference to interactions observed in similar systems both in the liquid and crystalline state, and predicted from theoretical calculations. The expected strong hydrogen bonds between the strong hydrogen bond donors and acceptors are observed, together with evidence of weaker CH hydrogen bonds and π interactions also playing a significant role in determining the arrangement of adjacent molecules.

  19. 40 CFR 93.154 - Conformity analysis.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Conformity analysis. 93.154 Section 93...) DETERMINING CONFORMITY OF FEDERAL ACTIONS TO STATE OR FEDERAL IMPLEMENTATION PLANS Determining Conformity of General Federal Actions to State or Federal Implementation Plans § 93.154 Conformity analysis. Any...

  20. New potentials for conformal mechanics

    CERN Document Server

    Papadopoulos, G

    2012-01-01

    We show that V=\\alpha x^2+\\beta x^{-2} arises as a potential of 1-dimensional conformal theories. This class of conformal models includes the DFF model \\alpha=0 and the harmonic oscillator \\beta=0. The construction is based on a different embedding of the conformal symmetry group into the time re-parameterizations from that of the DFF model and its generalizations. Depending on the range of the couplings $\\alpha, \\beta$, these models can have a ground state and a well-defined energy spectrum, and exhibit either a $SL(2,\\bR)$ or a SO(3) conformal symmetry. The latter group can also be embedded in Diff(S^1). We also present several generalizations of these models which include the Calogero models with harmonic oscillator couplings and non-linear models with suitable metric and potential couplings. In addition, we give the conditions on the couplings for a class of gaugetheories to admit a SL(2,\\bR) or SO(3) conformal symmetry. We present examples of such systems with general gauge groups and global symmetries t...

  1. Automatic Tool for Local Assembly Structures

    Energy Technology Data Exchange (ETDEWEB)

    2016-10-11

    Whole community shotgun sequencing of total DNA (i.e. metagenomics) and total RNA (i.e. metatranscriptomics) has provided a wealth of information in the microbial community structure, predicted functions, metabolic networks, and is even able to reconstruct complete genomes directly. Here we present ATLAS (Automatic Tool for Local Assembly Structures) a comprehensive pipeline for assembly, annotation, genomic binning of metagenomic and metatranscriptomic data with an integrated framework for Multi-Omics. This will provide an open source tool for the Multi-Omic community at large.

  2. Automatic Associations with “Erotic” in Child Sexual Offenders: Identifying Those in Danger of Reoffence

    OpenAIRE

    Melanie Caroline Steffens; Elena Yundina; Markus Panning

    2008-01-01

    If sexual offence (rape or sexual abuse) has aspects of automatic rather than controlled behavior in the sense of being triggered by situational cues, it might be predicted better by reaction-time measures of automatic cognition rather than by questionnaires. Two Implicit Association Tests (IATs) were used to test whether male pedophile and sadistic offenders (N = 46) differ from each other and from a male control group (N = 47) with regard to their automatic associations of erotic. The first...

  3. Probabilistic sampling of protein conformations: new hope for brute force?

    Science.gov (United States)

    Feldman, Howard J; Hogue, Christopher W V

    2002-01-01

    Protein structure prediction from sequence alone by "brute force" random methods is a computationally expensive problem. Estimates have suggested that it could take all the computers in the world longer than the age of the universe to compute the structure of a single 200-residue protein. Here we investigate the use of a faster version of our FOLDTRAJ probabilistic all-atom protein-structure-sampling algorithm. We have improved the method so that it is now over twenty times faster than originally reported, and capable of rapidly sampling conformational space without lattices. It uses geometrical constraints and a Leonard-Jones type potential for self-avoidance. We have also implemented a novel method to add secondary structure-prediction information to make protein-like amounts of secondary structure in sampled structures. In a set of 100,000 probabilistic conformers of 1VII, 1ENH, and 1PMC generated, the structures with smallest Calpha RMSD from native are 3.95, 5.12, and 5.95A, respectively. Expanding this test to a set of 17 distinct protein folds, we find that all-helical structures are "hit" by brute force more frequently than beta or mixed structures. For small helical proteins or very small non-helical ones, this approach should have a "hit" close enough to detect with a good scoring function in a pool of several million conformers. By fitting the distribution of RMSDs from the native state of each of the 17 sets of conformers to the extreme value distribution, we are able to estimate the size of conformational space for each. With a 0.5A RMSD cutoff, the number of conformers is roughly 2N where N is the number of residues in the protein. This is smaller than previous estimates, indicating an average of only two possible conformations per residue when sterics are accounted for. Our method reduces the effective number of conformations available at each residue by probabilistic bias, without requiring any particular discretization of residue conformational

  4. Automatic Kurdish Dialects Identification

    Directory of Open Access Journals (Sweden)

    Hossein Hassani

    2016-02-01

    Full Text Available Automatic dialect identification is a necessary Lan guage Technology for processing multi- dialect languages in which the dialects are linguis tically far from each other. Particularly, this becomes crucial where the dialects are mutually uni ntelligible. Therefore, to perform computational activities on these languages, the sy stem needs to identify the dialect that is the subject of the process. Kurdish language encompasse s various dialects. It is written using several different scripts. The language lacks of a standard orthography. This situation makes the Kurdish dialectal identification more interesti ng and required, both form the research and from the application perspectives. In this research , we have applied a classification method, based on supervised machine learning, to identify t he dialects of the Kurdish texts. The research has focused on two widely spoken and most dominant Kurdish dialects, namely, Kurmanji and Sorani. The approach could be applied to the other Kurdish dialects as well. The method is also applicable to the languages which are similar to Ku rdish in their dialectal diversity and differences.

  5. Renyi entropy and conformal defects

    Energy Technology Data Exchange (ETDEWEB)

    Bianchi, Lorenzo [Humboldt-Univ. Berlin (Germany). Inst. fuer Physik; Hamburg Univ. (Germany). II. Inst. fuer Theoretische Physik; Meineri, Marco [Scuola Normale Superiore, Pisa (Italy); Perimeter Institute for Theoretical Physics, Waterloo, ON (Canada); Istituto Nazionale di Fisica Nucleare, Pisa (Italy); Myers, Robert C. [Perimeter Institute for Theoretical Physics, Waterloo, ON (Canada); Smolkin, Michael [California Univ., Berkely, CA (United States). Center for Theoretical Physics and Department of Physics

    2016-04-18

    We propose a field theoretic framework for calculating the dependence of Renyi entropies on the shape of the entangling surface in a conformal field theory. Our approach rests on regarding the corresponding twist operator as a conformal defect and in particular, we define the displacement operator which implements small local deformations of the entangling surface. We identify a simple constraint between the coefficient defining the two-point function of the displacement operator and the conformal weight of the twist operator, which consolidates a number of distinct conjectures on the shape dependence of the Renyi entropy. As an example, using this approach, we examine a conjecture regarding the universal coefficient associated with a conical singularity in the entangling surface for CFTs in any number of spacetime dimensions. We also provide a general formula for the second order variation of the Renyi entropy arising from small deformations of a spherical entangling surface, extending Mezei's results for the entanglement entropy.

  6. Lectures on Conformal Field Theory

    CERN Document Server

    Qualls, Joshua D

    2015-01-01

    These lectures notes are based on courses given at National Taiwan University, National Chiao-Tung University, and National Tsing Hua University in the spring term of 2015. Although the course was offered primarily for graduate students, these lecture notes have been prepared for a more general audience. They are intended as an introduction to conformal field theories in various dimensions, with applications related to topics of particular interest: topics include the conformal bootstrap program, boundary conformal field theory, and applications related to the AdS/CFT correspondence. We assume the reader to be familiar with quantum mechanics at the graduate level and to have some basic knowledge of quantum field theory. Familiarity with string theory is not a prerequisite for this lectures, although it can only help.

  7. Conformal Anomalies and Gravitational Waves

    CERN Document Server

    Meissner, Krzysztof A

    2016-01-01

    We argue that the presence of conformal anomalies in gravitational theories can lead to observable modifications to Einstein's equations via the induced anomalous effective actions, whose non-localities can overwhelm the smallness of the Planck scale. The fact that no such effects have been seen in recent cosmological or gravitational wave observations therefore imposes strong restrictions on the field content of possible extensions of Einstein's theory: all viable theories should have vanishing conformal anomalies. We then show that, among presently known theories, a complete cancellation of conformal anomalies in $D=4$ for both the $C^2$ invariant and the Euler (Gauss-Bonnet) invariant $E_4$ can only be achieved for $N$-extended supergravities with $N\\geq 5$, as well as for M theory compactified to four dimensions.

  8. Conformal geometry and quasiregular mappings

    CERN Document Server

    Vuorinen, Matti

    1988-01-01

    This book is an introduction to the theory of spatial quasiregular mappings intended for the uninitiated reader. At the same time the book also addresses specialists in classical analysis and, in particular, geometric function theory. The text leads the reader to the frontier of current research and covers some most recent developments in the subject, previously scatterd through the literature. A major role in this monograph is played by certain conformal invariants which are solutions of extremal problems related to extremal lengths of curve families. These invariants are then applied to prove sharp distortion theorems for quasiregular mappings. One of these extremal problems of conformal geometry generalizes a classical two-dimensional problem of O. Teichmüller. The novel feature of the exposition is the way in which conformal invariants are applied and the sharp results obtained should be of considerable interest even in the two-dimensional particular case. This book combines the features of a textbook an...

  9. Conformal Mapping for Multiple Terminals

    CERN Document Server

    Wang, Weimin; Wang, Qiang; Ren, Hao

    2015-01-01

    Conformal mapping is an important mathematical tool in many physical and engineering fields, especially in electrostatics, fluid mechanics, classical mechanics, and transformation optics. However in the existing textbooks and literatures, it is only adopted to solve the problems which have only two terminals. Two terminals with electric potential differences, pressure difference, optical path difference, etc., can be mapped conformally onto a solvable structure, e.g., a rectangle, where the two terminals are mapped onto two opposite edges of the rectangle. Here we show a conformal mapping method for multiple terminals, which is more common in practical applications. Through accurate analysis of the boundary conditions, additional terminals or boundaries are folded in the inner of the mapped rectangle. Then the solution will not be influenced. The method is described in several typical situations and two application examples are detailed. The first example is an electrostatic actuator with three electrodes. A ...

  10. Universality class in conformal inflation

    Energy Technology Data Exchange (ETDEWEB)

    Kallosh, Renata; Linde, Andrei, E-mail: kallosh@stanford.edu, E-mail: alinde@stanford.edu [Department of Physics and SITP, Stanford University, Stanford, California 94305 (United States)

    2013-07-01

    We develop a new class of chaotic inflation models with spontaneously broken conformal invariance. Observational consequences of a broad class of such models are stable with respect to strong deformations of the scalar potential. This universality is a critical phenomenon near the point of enhanced symmetry, SO(1,1), in case of conformal inflation. It appears because of the exponential stretching of the moduli space and the resulting exponential flattening of scalar potentials upon switching from the Jordan frame to the Einstein frame in this class of models. This result resembles stretching and flattening of inhomogeneities during inflationary expansion. It has a simple interpretation in terms of velocity versus rapidity near the Kähler cone in the moduli space, similar to the light cone of special theory of relativity. This effect makes inflation possible even in the models with very steep potentials. We describe conformal and superconformal versions of this cosmological attractor mechanism.

  11. Electronic amplifiers for automatic compensators

    CERN Document Server

    Polonnikov, D Ye

    1965-01-01

    Electronic Amplifiers for Automatic Compensators presents the design and operation of electronic amplifiers for use in automatic control and measuring systems. This book is composed of eight chapters that consider the problems of constructing input and output circuits of amplifiers, suppression of interference and ensuring high sensitivity.This work begins with a survey of the operating principles of electronic amplifiers in automatic compensator systems. The succeeding chapters deal with circuit selection and the calculation and determination of the principal characteristics of amplifiers, as

  12. The Automatic Telescope Network (ATN)

    CERN Document Server

    Mattox, J R

    1999-01-01

    Because of the scheduled GLAST mission by NASA, there is strong scientific justification for preparation for very extensive blazar monitoring in the optical bands to exploit the opportunity to learn about blazars through the correlation of variability of the gamma-ray flux with flux at lower frequencies. Current optical facilities do not provide the required capability.Developments in technology have enabled astronomers to readily deploy automatic telescopes. The effort to create an Automatic Telescope Network (ATN) for blazar monitoring in the GLAST era is described. Other scientific applications of the networks of automatic telescopes are discussed. The potential of the ATN for science education is also discussed.

  13. Epigenetic dominance of prion conformers.

    Directory of Open Access Journals (Sweden)

    Eri Saijo

    2013-10-01

    Full Text Available Although they share certain biological properties with nucleic acid based infectious agents, prions, the causative agents of invariably fatal, transmissible neurodegenerative disorders such as bovine spongiform encephalopathy, sheep scrapie, and human Creutzfeldt Jakob disease, propagate by conformational templating of host encoded proteins. Once thought to be unique to these diseases, this mechanism is now recognized as a ubiquitous means of information transfer in biological systems, including other protein misfolding disorders such as those causing Alzheimer's and Parkinson's diseases. To address the poorly understood mechanism by which host prion protein (PrP primary structures interact with distinct prion conformations to influence pathogenesis, we produced transgenic (Tg mice expressing different sheep scrapie susceptibility alleles, varying only at a single amino acid at PrP residue 136. Tg mice expressing ovine PrP with alanine (A at (OvPrP-A136 infected with SSBP/1 scrapie prions propagated a relatively stable (S prion conformation, which accumulated as punctate aggregates in the brain, and produced prolonged incubation times. In contrast, Tg mice expressing OvPrP with valine (V at 136 (OvPrP-V136 infected with the same prions developed disease rapidly, and the converted prion was comprised of an unstable (U, diffusely distributed conformer. Infected Tg mice co-expressing both alleles manifested properties consistent with the U conformer, suggesting a dominant effect resulting from exclusive conversion of OvPrP-V136 but not OvPrP-A136. Surprisingly, however, studies with monoclonal antibody (mAb PRC5, which discriminates OvPrP-A136 from OvPrP-V136, revealed substantial conversion of OvPrP-A136. Moreover, the resulting OvPrP-A136 prion acquired the characteristics of the U conformer. These results, substantiated by in vitro analyses, indicated that co-expression of OvPrP-V136 altered the conversion potential of OvPrP-A136 from the S to

  14. Nonlocal gravity: Conformally flat spacetimes

    CERN Document Server

    Bini, Donato

    2016-01-01

    The field equations of the recent nonlocal generalization of Einstein's theory of gravitation are presented in a form that is reminiscent of general relativity. The implications of the nonlocal field equations are studied in the case of conformally flat spacetimes. Even in this simple case, the field equations are intractable. Therefore, to gain insight into the nature of these equations, we investigate the structure of nonlocal gravity in two-dimensional spacetimes. While any smooth 2D spacetime is conformally flat and satisfies Einstein's field equations, only a subset containing either a Killing vector or a homothetic Killing vector can satisfy the field equations of nonlocal gravity.

  15. Detection prospects for conformally constrained vector-portal dark matter

    CERN Document Server

    Sage, Frederick S; Dick, Rainer; Steele, T G; Mann, R B

    2016-01-01

    We work with a UV conformal U(1)' extension of the Standard Model, motivated by the hierarchy problem and recent collider anomalies. This model admits fermionic vector portal WIMP dark matter charged under the U(1)' gauge group. The asymptotically safe boundary conditions can be used to fix the coupling parameters, which allows the observed thermal relic abundance to constrain the mass of the dark matter particle. This highly restricts the parameter space, allowing strong predictions to be made. The parameter space of several UV conformal U(1)' scenarios will be explored, and both bounds and possible signals from direct and indirect detection observation methods will be discussed.

  16. Conformal Extensions of the Standard Model with Veltman Conditions

    DEFF Research Database (Denmark)

    Antipin, Oleg; Mojaza, Matin; Sannino, Francesco

    2014-01-01

    Using the renormalisation group framework we classify different extensions of the standard model according to their degree of naturality. A new relevant class of perturbative models involving elementary scalars is the one in which the theory simultaneously satisfies the Veltman conditions...... and is conformal at the classical level. We term these extensions perturbative natural conformal (PNC) theories. We show that PNC models are very constrained and thus highly predictive. Among the several PNC examples that we exhibit, we discover a remarkably simple PNC extension of the standard model in which...

  17. Automatic quantification of subarachnoid hemorrhage on noncontrast CT

    NARCIS (Netherlands)

    Boers, A.M.; Zijlstra, I.A.; Gathier, C.S.; Berg, van den R.; Slump, C.H.; Marquering, H.A.; Majoie, C.B.

    2014-01-01

    Quantification of blood after SAH on initial NCCT is an important radiologic measure to predict patient outcome and guide treatment decisions. In current scales, hemorrhage volume and density are not accounted for. The purpose of this study was to develop and validate a fully automatic method for SA

  18. Automatic programming of simulation models

    Science.gov (United States)

    Schroer, Bernard J.; Tseng, Fan T.; Zhang, Shou X.; Dwan, Wen S.

    1988-01-01

    The objective of automatic programming is to improve the overall environment for describing the program. This improved environment is realized by a reduction in the amount of detail that the programmer needs to know and is exposed to. Furthermore, this improved environment is achieved by a specification language that is more natural to the user's problem domain and to the user's way of thinking and looking at the problem. The goal of this research is to apply the concepts of automatic programming (AP) to modeling discrete event simulation system. Specific emphasis is on the design and development of simulation tools to assist the modeler define or construct a model of the system and to then automatically write the corresponding simulation code in the target simulation language, GPSS/PC. A related goal is to evaluate the feasibility of various languages for constructing automatic programming simulation tools.

  19. Clothes Dryer Automatic Termination Evaluation

    Energy Technology Data Exchange (ETDEWEB)

    TeGrotenhuis, Ward E.

    2014-10-01

    Volume 2: Improved Sensor and Control Designs Many residential clothes dryers on the market today provide automatic cycles that are intended to stop when the clothes are dry, as determined by the final remaining moisture content (RMC). However, testing of automatic termination cycles has shown that many dryers are susceptible to over-drying of loads, leading to excess energy consumption. In particular, tests performed using the DOE Test Procedure in Appendix D2 of 10 CFR 430 subpart B have shown that as much as 62% of the energy used in a cycle may be from over-drying. Volume 1 of this report shows an average of 20% excess energy from over-drying when running automatic cycles with various load compositions and dryer settings. Consequently, improving automatic termination sensors and algorithms has the potential for substantial energy savings in the U.S.

  20. Temperature: Human Regulating, Ants Conforming

    Science.gov (United States)

    Clopton, Joe R.

    2007-01-01

    Biological processes speed up as temperature rises. Procedures for demonstrating this with ants traveling on trails, and data gathered by students on the Argentine ant ("Linepithema humile") are presented. The concepts of temperature regulation and conformity are detailed with a focus on the processes rather than on terms that label the organisms.

  1. Defects in conformal field theory

    Science.gov (United States)

    Billò, Marco; Gonçalves, Vasco; Lauria, Edoardo; Meineri, Marco

    2016-04-01

    We discuss consequences of the breaking of conformal symmetry by a flat or spherical extended operator. We adapt the embedding formalism to the study of correlation functions of symmetric traceless tensors in the presence of the defect. Two-point functions of a bulk and a defect primary are fixed by conformal invariance up to a set of OPE coefficients, and we identify the allowed tensor structures. A correlator of two bulk primaries depends on two cross-ratios, and we study its conformal block decomposition in the case of external scalars. The Casimir equation in the defect channel reduces to a hypergeometric equation, while the bulk channel blocks are recursively determined in the light-cone limit. In the special case of a defect of codimension two, we map the Casimir equation in the bulk channel to the one of a four-point function without defect. Finally, we analyze the contact terms of the stress-tensor with the extended operator, and we deduce constraints on the CFT data. In two dimensions, we relate the displacement operator, which appears among the contact terms, to the reflection coefficient of a conformal interface, and we find unitarity bounds for the latter.

  2. Boundary Logarithmic Conformal Field Theory

    CERN Document Server

    Kogan, I I; Kogan, Ian I.; Wheater, John F.

    2000-01-01

    We discuss the effect of boundaries in boundary logarithmic conformal field theory and show, with reference to both $c=-2$ and $c=0$ models, how they produce new features even in bulk correlation functions which are not present in the corresponding models without boundaries. We show how Cardy's relation between boundary states and bulk quantities is modified.

  3. Automatic Number Plate Recognition System

    OpenAIRE

    Rajshree Dhruw; Dharmendra Roy

    2014-01-01

    Automatic Number Plate Recognition (ANPR) is a mass surveillance system that captures the image of vehicles and recognizes their license number. The objective is to design an efficient automatic authorized vehicle identification system by using the Indian vehicle number plate. In this paper we discus different methodology for number plate localization, character segmentation & recognition of the number plate. The system is mainly applicable for non standard Indian number plates by recognizing...

  4. Generating Capacity Prediction of Automatic Tracking Power Generation System on Inflatable Membrane Greenhouse Attached Photovoltaic%光伏充气膜温室自跟踪发电系统发电量预测

    Institute of Scientific and Technical Information of China (English)

    徐小力; 刘秋爽; 见浪護

    2012-01-01

    A method which can forecast generating capacity of automatic tracking power system on inflatable membrane greenhouse attached photovoltaic was proposed based on the self-adaptive variation particle swarm neural network by adding with weather information. Firstly, through combining historical data of electricity production and meteorological data, the main factors of the impact on generating capacity of power generation system on inflatable membrane greenhouse attached photovoltaic was analyzed. Then, the neural network forecasting model was established by combining the weather forecast. The self-adaptive variation particle swarm algorithm was introduced to improve the training effect by tackling the problems of slowly converging, easily falling into local optimum, and difficultly converging existed in traditional neural network forecasting model based on gradient-descent BP algorithm. The neural network was optimized with adaptable mutation particle swarm optimization ( AMPSO) algorithm. The mutation was put into particle swarm optimization(PSO) algorithm to find local optimal value. Experimental results showed that the entire convergence performance was significantly improved by adopting AMPSO and the premature convergence problem can be effectively avoided in PSO.%针对光伏充气膜温室自跟踪发电系统提出了一种加入天气预报信息的自适应变异粒子群神经网络的发电量预测算法.首先结合历史发电量数据和气象数据分析了影响光伏充气膜温室自跟踪发电系统发电量的主要因素,建立了加入天气预报的神经网络预测模型,并针对传统神经网络预测模型中基于梯度下降的BP算法收敛慢、易陷入局部最优、训练难收敛等问题,通过自适应变异粒子群算法改进了神经网络.该算法通过将变异环节引入粒子群优化算法,进行隔代进化找到局部最优解.实验结果表明所采用的自适应变异粒子群的神经网络预测算法的全

  5. A sampling approach for protein backbone fragment conformations.

    Science.gov (United States)

    Yu, J Y; Zhang, W

    2013-01-01

    In protein structure prediction, backbone fragment bias information can narrow down the conformational space of the whole polypeptide chain significantly. Unlike existing methods that use fragments as building blocks, the paper presents a probabilistic sampling approach for protein backbone torsion angles by modelling angular correlation of (phi, psi) with a directional statistics distribution. Given a protein sequence and secondary structure information, this method samples backbone fragments conformations by using a backtrack sampling algorithm for the hidden Markov model with multiple inputs and a single output. The proposed approach is applied to a fragment library, and some well-known structural motifs are sampled very well on the optimal path. Computational results show that the method can help to obtain native-like backbone fragments conformations. PMID:23777175

  6. Automatic analysis of double coronal mass ejections from coronagraph images

    Science.gov (United States)

    Jacobs, Matthew; Chang, Lin-Ching; Pulkkinen, Antti; Romano, Michelangelo

    2015-11-01

    Coronal mass ejections (CMEs) can have major impacts on man-made technology and humans, both in space and on Earth. These impacts have created a high interest in the study of CMEs in an effort to detect and track events and forecast the CME arrival time to provide time for proper mitigation. A robust automatic real-time CME processing pipeline is greatly desired to avoid laborious and subjective manual processing. Automatic methods have been proposed to segment CMEs from coronagraph images and estimate CME parameters such as their heliocentric location and velocity. However, existing methods suffered from several shortcomings such as the use of hard thresholding and an inability to handle two or more CMEs occurring within the same coronagraph image. Double-CME analysis is a necessity for forecasting the many CME events that occur within short time frames. Robust forecasts for all CME events are required to fully understand space weather impacts. This paper presents a new method to segment CME masses and pattern recognition approaches to differentiate two CMEs in a single coronagraph image. The proposed method is validated on a data set of 30 halo CMEs, with results showing comparable ability in transient arrival time prediction accuracy and the new ability to automatically predict the arrival time of a double-CME event. The proposed method is the first automatic method to successfully calculate CME parameters from double-CME events, making this automatic method applicable to a wider range of CME events.

  7. Fake conformal symmetry in unimodular gravity

    Science.gov (United States)

    Oda, Ichiro

    2016-08-01

    We study Weyl symmetry (local conformal symmetry) in unimodular gravity. It is shown that the Noether currents for both Weyl symmetry and global scale symmetry vanish exactly as in conformally invariant scalar-tensor gravity. We clearly explain why in the class of conformally invariant gravitational theories, the Noether currents vanish by starting with conformally invariant scalar-tensor gravity. Moreover, we comment on both classical and quantum-mechanical equivalences in Einstein's general relativity, conformally invariant scalar-tensor gravity, and the Weyl-transverse gravity. Finally, we discuss the Weyl current in the conformally invariant scalar action and see that it is also vanishing.

  8. Minimal Conformal Extensions of the Higgs Sector

    CERN Document Server

    Helmboldt, Alexander J; Lindner, Manfred; Smirnov, Juri

    2016-01-01

    In this work we find the minimal extension of the Standard Model's Higgs sector which can lead to a light Higgs boson via radiative symmetry breaking and is consistent with the phenomenological requirements for a low-energy realization of a conformal theory. The model which turns out to be stable under renormalization group translations is an extension of the Standard Model by two scalar fields, one of which acquires a finite vacuum expectation value and therefore mixes into the physical Higgs. We find that the minimal model predicts a sizable amount of mixing which makes it testable at a collider. In addition to the physical Higgs, the theory's scalar spectrum contains one light and one heavy boson. The heavy scalar's properties render it a potential dark matter candidate.

  9. Improvements to robotics-inspired conformational sampling in rosetta.

    Directory of Open Access Journals (Sweden)

    Amelie Stein

    Full Text Available To accurately predict protein conformations in atomic detail, a computational method must be capable of sampling models sufficiently close to the native structure. All-atom sampling is difficult because of the vast number of possible conformations and extremely rugged energy landscapes. Here, we test three sampling strategies to address these difficulties: conformational diversification, intensification of torsion and omega-angle sampling and parameter annealing. We evaluate these strategies in the context of the robotics-based kinematic closure (KIC method for local conformational sampling in Rosetta on an established benchmark set of 45 12-residue protein segments without regular secondary structure. We quantify performance as the fraction of sub-Angstrom models generated. While improvements with individual strategies are only modest, the combination of intensification and annealing strategies into a new "next-generation KIC" method yields a four-fold increase over standard KIC in the median percentage of sub-Angstrom models across the dataset. Such improvements enable progress on more difficult problems, as demonstrated on longer segments, several of which could not be accurately remodeled with previous methods. Given its improved sampling capability, next-generation KIC should allow advances in other applications such as local conformational remodeling of multiple segments simultaneously, flexible backbone sequence design, and development of more accurate energy functions.

  10. Conformal invariance in the quantum field theory

    International Nuclear Information System (INIS)

    Basic features concerning the present knowledge of conformal symmetry are illustrated in a simple model. Composite field dimensions of this model are computed and related to the conformal group. (author)

  11. Conformal methods in general relativity

    CERN Document Server

    Valiente Kroon, Juan A

    2016-01-01

    This book offers a systematic exposition of conformal methods and how they can be used to study the global properties of solutions to the equations of Einstein's theory of gravity. It shows that combining these ideas with differential geometry can elucidate the existence and stability of the basic solutions of the theory. Introducing the differential geometric, spinorial and PDE background required to gain a deep understanding of conformal methods, this text provides an accessible account of key results in mathematical relativity over the last thirty years, including the stability of de Sitter and Minkowski spacetimes. For graduate students and researchers, this self-contained account includes useful visual models to help the reader grasp abstract concepts and a list of further reading, making this the perfect reference companion on the topic.

  12. Conformal gravity and "gravitational bubbles"

    CERN Document Server

    Berezin, V A; Eroshenko, Yu N

    2015-01-01

    We describe the general structure of the spherically symmetric solutions in the Weyl conformal gravity. The corresponding Bach equations are derived for the special type of metrics, which can be considered as the representative of the general class. The complete set of the pure vacuum solutions, consisting of two classes, is found. The first one contains the solutions with constant two-dimensional curvature scalar, and the representatives are the famous Robertson--Walker metrics. We called one of them the "gravitational bubbles", which is compact and with zero Weyl tensor. These "gravitational bubbles" are the pure vacuum curved space-times (without any material sources, including the cosmological constant), which are absolutely impossible in General Relativity. This phenomenon makes it easier to create the universe from "nothing". The second class consists of the solutions with varying curvature scalar. We found its representative as the one-parameter family, which can be conformally covered by the thee-para...

  13. Conformal Bootstrap in Mellin Space

    CERN Document Server

    Gopakumar, Rajesh; Sen, Kallol; Sinha, Aninda

    2016-01-01

    We propose a new approach towards analytically solving for the dynamical content of Conformal Field Theories (CFTs) using the bootstrap philosophy. This combines the original bootstrap idea of Polyakov with the modern technology of the Mellin representation of CFT amplitudes. We employ exchange Witten diagrams with built in crossing symmetry as our basic building blocks rather than the conventional conformal blocks in a particular channel. Demanding consistency with the operator product expansion (OPE) implies an infinite set of constraints on operator dimensions and OPE coefficients. We illustrate the power of this method in the epsilon expansion of the Wilson-Fisher fixed point by computing operator dimensions and, strikingly, OPE coefficients to higher orders in epsilon than currently available using other analytic techniques (including Feynman diagram calculations). Our results enable us to get a somewhat better agreement of certain observables in the 3d Ising model, with the precise numerical values that...

  14. Conformal symmetries in warped manifolds

    Energy Technology Data Exchange (ETDEWEB)

    Apostolopoulos, P S [University of Athens, Department of Physics, Nuclear and Particle Physics Section, Panepistimiopolis, Zografos 15771, Athens (Greece); Carot, J G [Departament de Fisica, Universitat de les Illes Balears, Cra. Valldemossa km 7.5, E-07122 Palma de Mallorca (Spain)

    2005-01-01

    The existence of a Conformal Vector Field (CVF) is studied in the important class of warped manifolds of arbitrary dimension generalizing in this way the corresponding results of the four dimensional geometries. As a concrete example we apply the geometric results in the case of brane-world scenarios when the bulk geometry admits a hypersurface orthogonal Killing Vector Field (KVF) and is filled with a perfect fluid matter content.

  15. Exceptional and Spinorial Conformal Windows

    DEFF Research Database (Denmark)

    Mojaza, Matin; Pica, Claudio; Ryttov, Thomas;

    2012-01-01

    We study the conformal window of gauge theories containing fermionic matter fields, where the gauge group is any of the exceptional groups with the fermions transforming according to the fundamental and adjoint representations and the orthogonal groups where the fermions transform according to a ...... to a spinorial representation. We investigate the phase diagram using a purely perturbative four loop analysis, the all-orders beta function and the ladder approximation....

  16. All N=4 Conformal Supergravities

    CERN Document Server

    Butter, Daniel; de Wit, Bernard; Sahoo, Bindusar

    2016-01-01

    All N=4 conformal supergravities in four space-time dimensions are constructed. These are the only N=4 supergravity theories whose actions are invariant under off-shell supersymmetry. They are encoded in terms of a holomorphic function that is homogeneous of zeroth degree in scalar fields that parametrize an SU(1,1)/U(1) coset space. When this function equals a constant the Lagrangian is invariant under continuous SU(1,1) transformations.

  17. Electrophysiological precursors of social conformity

    OpenAIRE

    Shestakova, Anna; Rieskamp, Jörg; Tugin, Sergey; Ossadtchi, Alexey; Krutitskaya, Janina; Klucharev, Vasily

    2013-01-01

    Humans often change their beliefs or behavior due to the behavior or opinions of others. This study explored, with the use of human event-related potentials (ERPs), whether social conformity is based on a general performance-monitoring mechanism. We tested the hypothesis that conflicts with a normative group opinion evoke a feedback-related negativity (FRN) often associated with performance monitoring and subsequent adjustment of behavior. The experimental results show that individual judgmen...

  18. NIR Laser Radiation Induced Conformational Changes and Tunneling Lifetimes of High-Energy Conformers of Amino Acids in Low-Temperature Matrices

    Science.gov (United States)

    Bazso, Gabor; Najbauer, Eszter E.; Magyarfalvi, Gabor; Tarczay, Gyorgy

    2013-06-01

    We review our recent results on combined matrix isolation FT-IR and NIR laser irradiation studies on glycine alanine, and cysteine. The OH and the NH stretching overtones of the low-energy conformers of these amino acids deposited in Ar, Kr, Xe, and N_{2} matrices were irradiated. At the expense of the irradiated conformer, other conformers were enriched and new, high-energy, formerly unobserved conformers were formed in the matrices. This enabled the separation and unambiguous assignment of the vibrational transitions of the different conformers. The main conversion paths and their efficiencies are described qualitatively showing that there are significant differences in different matrices. It was shown that the high-energy conformer decays in the matrix by H-atom tunneling. The lifetimes of the high-energy conformers in different matrices were measured. Based on our results we conclude that some theoretically predicted low-energy conformers of amino acids are likely even absent in low-energy matrices due to fast H-atom tunneling. G. Bazso, G. Magyarfalvi, G. Tarczay J. Mol. Struct. 1025 (Light-Induced Processes in Cryogenic Matrices Special Issue) 33-42 (2012). G. Bazso, G. Magyarfalvi, G. Tarczay J. Phys. Chem. A 116 (43) 10539-10547 (2012). G. Bazso, E. E. Najbauer, G. Magyarfalvi, G. Tarczay J. Phys. Chem. A in press, DOI: 10.1021/jp400196b. E. E. Najbauer, G. Bazso, G. Magyarfalvi, G. Tarczay in preparation.

  19. Electrophysiological precursors of social conformity.

    Science.gov (United States)

    Shestakova, Anna; Rieskamp, Jörg; Tugin, Sergey; Ossadtchi, Alexey; Krutitskaya, Janina; Klucharev, Vasily

    2013-10-01

    Humans often change their beliefs or behavior due to the behavior or opinions of others. This study explored, with the use of human event-related potentials (ERPs), whether social conformity is based on a general performance-monitoring mechanism. We tested the hypothesis that conflicts with a normative group opinion evoke a feedback-related negativity (FRN) often associated with performance monitoring and subsequent adjustment of behavior. The experimental results show that individual judgments of facial attractiveness were adjusted in line with a normative group opinion. A mismatch between individual and group opinions triggered a frontocentral negative deflection with the maximum at 200 ms, similar to FRN. Overall, a conflict with a normative group opinion triggered a cascade of neuronal responses: from an earlier FRN response reflecting a conflict with the normative opinion to a later ERP component (peaking at 380 ms) reflecting a conforming behavioral adjustment. These results add to the growing literature on neuronal mechanisms of social influence by disentangling the conflict-monitoring signal in response to the perceived violation of social norms and the neural signal of a conforming behavioral adjustment.

  20. Conformally symmetric massive discrete fields

    Energy Technology Data Exchange (ETDEWEB)

    Souza, Manoelito M. de

    2001-04-01

    Conformal symmetry is taken as an attribute of theories of massless fields in manifolds with specific dimensions. This paper shows that this is not an absolute truth; it is a consequence of the mathematical representation used for the physical interactions. It introduces a new kind of representation where the propagation of massive (invariant mass) and mass-less interactions are unifiedly described by a single conformally symmetric Green's function. Sources and fields are treated at a same footing, symmetrically, as discrete fields - the fields in this new representation - fields defined with support on straight lines embedded in a (3+1) - Minkowski manifold. The discrete field turns out to be a point in phase space. It is finite everywhere. With a finite number of degrees of freedom it does not share the well known problems faced by the standard continuous formalism which can be retrieved from the discrete one by an integration over a hypersurface. The passage from discrete to continuous fields illuminates the physical meaning and origins of their properties and problems. The price for having massive discrete field with conformal symmetry is of hiding its mass and timelike velocity behind its non-constant proper-time. (author)

  1. Conformal window and Landau singularities

    CERN Document Server

    Grunberg, G

    2001-01-01

    A physical characterization of Landau singularities is emphasized, which should trace the lower boundary N_f^* of the conformal window in QCD and supersymmetric QCD. A natural way to disentangle ``perturbative'' from ``non-perturbative'' contributions below N_f^* is suggested. Assuming an infrared fixed point is present in the perturbative part of the QCD coupling even in some range below N_f^* leads to the condition gamma(N_f^*)=1, where gamma is the critical exponent. Using the Banks-Zaks expansion, one gets 4conformal window. Some evidence for such a fixed point in QCD is provided through a modified Banks-Zaks expansion. Conformal window amplitudes, which contain power contributions, are show...

  2. Electrophysiological precursors of social conformity.

    Science.gov (United States)

    Shestakova, Anna; Rieskamp, Jörg; Tugin, Sergey; Ossadtchi, Alexey; Krutitskaya, Janina; Klucharev, Vasily

    2013-10-01

    Humans often change their beliefs or behavior due to the behavior or opinions of others. This study explored, with the use of human event-related potentials (ERPs), whether social conformity is based on a general performance-monitoring mechanism. We tested the hypothesis that conflicts with a normative group opinion evoke a feedback-related negativity (FRN) often associated with performance monitoring and subsequent adjustment of behavior. The experimental results show that individual judgments of facial attractiveness were adjusted in line with a normative group opinion. A mismatch between individual and group opinions triggered a frontocentral negative deflection with the maximum at 200 ms, similar to FRN. Overall, a conflict with a normative group opinion triggered a cascade of neuronal responses: from an earlier FRN response reflecting a conflict with the normative opinion to a later ERP component (peaking at 380 ms) reflecting a conforming behavioral adjustment. These results add to the growing literature on neuronal mechanisms of social influence by disentangling the conflict-monitoring signal in response to the perceived violation of social norms and the neural signal of a conforming behavioral adjustment. PMID:22683703

  3. Defects in conformal field theory

    CERN Document Server

    Billò, Marco; Lauria, Edoardo; Meineri, Marco

    2016-01-01

    We discuss consequences of the breaking of conformal symmetry by a flat or spherical extended operator. We adapt the embedding formalism to the study of correlation functions of symmetric traceless tensors in the presence of the defect. Two-point functions of a bulk and a defect primary are fixed by conformal invariance up to a set of OPE coefficients, and we identify the allowed tensor structures. A correlator of two bulk primaries depends on two cross-ratios, and we study its conformal block decomposition in the case of external scalars. The Casimir equation in the defect channel reduces to a hypergeometric equation, while the bulk channel blocks are recursively determined in the light-cone limit. In the special case of a defect of codimension two, we map the Casimir equation in the bulk channel to the one of a four-point function without defect. Finally, we analyze the contact terms of the stress-tensor with the extended operator, and we deduce constraints on the CFT data. In two dimensions, we relate the ...

  4. 40 CFR 51.854 - Conformity analysis.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 2 2010-07-01 2010-07-01 false Conformity analysis. 51.854 Section 51... FOR PREPARATION, ADOPTION, AND SUBMITTAL OF IMPLEMENTATION PLANS Determining Conformity of General Federal Actions to State or Federal Implementation Plans § 51.854 Conformity analysis. Link to...

  5. Conformally reducible 1+3 spacetimes

    CERN Document Server

    Carot, Jaume; Tupper, Brian O J

    2013-01-01

    Spacetimes which are conformally related to reducible 1+3 spacetimes are considered. We classify these spacetimes according to the conformal algebra of the underlying reducible spacetime, giving in each case canonical expressions for the metric and conformal Killing vectors, and provide physically meaningful examples.

  6. Conformally reducible 1+3 spacetimes

    Energy Technology Data Exchange (ETDEWEB)

    Carot, Jaume [Departament de Fisica, Universitat de les Illes Balears, Cra. Valldemossa km 7.5, E-07122 Palma de Mallorca (Spain); Keane, Aidan J [87 Carlton Place, Glasgow G5 9TD, Scotland (United Kingdom); Tupper, Brian O J [Department of Mathematics and Statistics, University of New Brunswick, Fredericton, NB E3B 5A3 (Canada)], E-mail: jcarot@uib.es, E-mail: aidan@countingthoughts.com, E-mail: bt32@rogers.com

    2008-03-07

    Spacetimes which are conformally related to reducible 1+3 spacetimes are considered. We classify these spacetimes according to the conformal algebra of the underlying reducible spacetime, giving in each case canonical expressions for the metric and conformal Killing vectors, and providing physically meaningful examples.

  7. Conformally Coupled Induced Gravity with Gradient Torsion

    OpenAIRE

    Yoon, Yongsung

    1999-01-01

    It is found that conformally coupled induced gravity with gradient torsion gives a dilaton gravity in Riemann geometry. In the Einstein frame of the dilaton gravity the conformal symmetry is hidden and a non-vanishing cosmological constant is not plausible due to the constraint of the conformal coupling.

  8. Recent Advances in Computational Conformal Geometry

    OpenAIRE

    Gu, Xianfeng David; Luo, Feng; Yau, Shing-Tung

    2009-01-01

    Computational conformal geometry focuses on developing the computational methodologies on discrete surfaces to discover conformal geometric invariants. In this work, we briefly summarize the recent developments for methods and related applications in computational conformal geometry. There are two major approaches, holomorphic differentials and curvature flow. Holomorphic differential method is a linear method, which is more efficient and robust to triangulations with lower qua...

  9. MIXED SELF-CONFORMAL MULTIFRACTAL MEASURES

    Institute of Scientific and Technical Information of China (English)

    Meifeng Dai

    2009-01-01

    Mixed multifractal analysis studies the simultaneous scaling behavior of finitely many measures. A self-conformal measure is a measure invariant under a set of conformal mappings. In this paper, we provide a description of the mixed multifractal theory of finitely many self-conformal measures.

  10. 21 CFR 886.3130 - Ophthalmic conformer.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Ophthalmic conformer. 886.3130 Section 886.3130...) MEDICAL DEVICES OPHTHALMIC DEVICES Prosthetic Devices § 886.3130 Ophthalmic conformer. (a) Identification. An ophthalmic conformer is a device usually made of molded plastic intended to be...

  11. Automatic integration of confidence in the brain valuation signal.

    Science.gov (United States)

    Lebreton, Maël; Abitbol, Raphaëlle; Daunizeau, Jean; Pessiglione, Mathias

    2015-08-01

    A key process in decision-making is estimating the value of possible outcomes. Growing evidence suggests that different types of values are automatically encoded in the ventromedial prefrontal cortex (VMPFC). Here we extend this idea by suggesting that any overt judgment is accompanied by a second-order valuation (a confidence estimate), which is also automatically incorporated in VMPFC activity. In accordance with the predictions of our normative model of rating tasks, two behavioral experiments showed that confidence levels were quadratically related to first-order judgments (age, value or probability ratings). The analysis of three functional magnetic resonance imaging data sets using similar rating tasks confirmed that the quadratic extension of first-order ratings (our proxy for confidence) was encoded in VMPFC activity, even if no confidence judgment was required of the participants. Such an automatic aggregation of value and confidence in a same brain region might provide insight into many distortions of judgment and choice. PMID:26192748

  12. Automatic Recognition of Facial Actions in Spontaneous Expressions

    Directory of Open Access Journals (Sweden)

    Marian Stewart Bartlett

    2006-09-01

    Full Text Available Spontaneous facial expressions differ from posed expressions in both which muscles are moved, and in the dynamics of the movement. Advances in the field of automatic facial expression measurement will require development and assessment on spontaneous behavior. Here we present preliminary results on a task of facial action detection in spontaneous facial expressions. We employ a user independent fully automatic system for real time recognition of facial actions from the Facial Action Coding System (FACS. The system automatically detects frontal faces in the video stream and coded each frame with respect to 20 Action units. The approach applies machine learning methods such as support vector machines and AdaBoost, to texture-based image representations. The output margin for the learned classifiers predicts action unit intensity. Frame-by-frame intensity measurements will enable investigations into facial expression dynamics which were previously intractable by human coding.

  13. Automatic mapping of monitoring data

    DEFF Research Database (Denmark)

    Lophaven, Søren; Nielsen, Hans Bruun; Søndergaard, Jacob

    2005-01-01

    This paper presents an approach, based on universal kriging, for automatic mapping of monitoring data. The performance of the mapping approach is tested on two data-sets containing daily mean gamma dose rates in Germany reported by means of the national automatic monitoring network (IMIS......). In the second dataset an accidental release of radioactivity in the environment was simulated in the South-Western corner of the monitored area. The approach has a tendency to smooth the actual data values, and therefore it underestimates extreme values, as seen in the second dataset. However, it is capable...

  14. Annual review in automatic programming

    CERN Document Server

    Goodman, Richard

    2014-01-01

    Annual Review in Automatic Programming focuses on the techniques of automatic programming used with digital computers. Topics covered range from the design of machine-independent programming languages to the use of recursive procedures in ALGOL 60. A multi-pass translation scheme for ALGOL 60 is described, along with some commercial source languages. The structure and use of the syntax-directed compiler is also considered.Comprised of 12 chapters, this volume begins with a discussion on the basic ideas involved in the description of a computing process as a program for a computer, expressed in

  15. Algorithms for skiascopy measurement automatization

    Science.gov (United States)

    Fomins, Sergejs; Trukša, Renārs; KrūmiĆa, Gunta

    2014-10-01

    Automatic dynamic infrared retinoscope was developed, which allows to run procedure at a much higher rate. Our system uses a USB image sensor with up to 180 Hz refresh rate equipped with a long focus objective and 850 nm infrared light emitting diode as light source. Two servo motors driven by microprocessor control the rotation of semitransparent mirror and motion of retinoscope chassis. Image of eye pupil reflex is captured via software and analyzed along the horizontal plane. Algorithm for automatic accommodative state analysis is developed based on the intensity changes of the fundus reflex.

  16. Automatic Construction of Finite Algebras

    Institute of Scientific and Technical Information of China (English)

    张健

    1995-01-01

    This paper deals with model generation for equational theories,i.e.,automatically generating (finite)models of a given set of (logical) equations.Our method of finite model generation and a tool for automatic construction of finite algebras is described.Some examples are given to show the applications of our program.We argue that,the combination of model generators and theorem provers enables us to get a better understanding of logical theories.A brief comparison betwween our tool and other similar tools is also presented.

  17. Robust simulations of viscoelastic flows at high Weissenberg numbers with the streamfunction/log-conformation formulation

    DEFF Research Database (Denmark)

    Comminal, Raphaël; Spangenberg, Jon; Hattel, Jesper Henri

    2015-01-01

    A new streamfunction/log-conformation formulation of incompressible viscoelastic flows is presented. The log-conformation representation guaranties the positive-definiteness of the conformation tensor and obviates the high Weissenberg number problem. The streamfunction is defined as a vector...... potential of the velocity field, and provides a pressureless formulation of the conservation laws, which automatically enforces the incompressibility. The resulting numerical method is free from velocity-pressure decoupling errors, and can achieve stable calculations for large Courant numbers, which improve...... the robustness and the efficiency of the solver. The two-dimensional flow of an Oldroyd-B fluid inside the lid-driven cavity is simulated for a large range of Weissenberg numbers. The numerical results demonstrate the second-order accuracy of our scheme, and our solutions are in good agreement with the available...

  18. A unified conformal model for fundamental interactions without dynamical Higgs field

    CERN Document Server

    Pawlowski, M; Marek Pawlowski; Ryszard Raczka

    1994-01-01

    A Higgsless model for strong, electro-weak and gravitational interactions is proposed. This model is based on the local symmetry group SU(3)xSU(2)xU(1)xC where C is the local conformal symmetry group. The natural minimal conformally invariant form of total lagrangian is postulated. It contains all Standard Model fields and gravitational interaction. Using the unitary gauge and the conformal scale fixing conditions we can eliminate all four real components of the Higgs doublet in this model. However the masses of vector mesons, leptons and quarks are automatically generated and are given by the same formulas as in the conventional Standard Model. The gravitational sector is analyzed and it is shown that the model admits in the classical limit the Einsteinian form of gravitational interactions. No figures.

  19. Automatic or Deliberate? Cerebral correlates of automatic associations towards performance enhancing substances

    Directory of Open Access Journals (Sweden)

    Sebastian eSchindler

    2015-12-01

    Full Text Available The direct assessment of explicit attitudes towards performance enhancing substances, for example Neuroenhancement or doping in sports can be affected by social desirability biases and cheating attempts. According to Dual Process Theories of cognition, indirect measures like the Implicit Association Test (IAT measure automatic associations towards a topic (as opposed to explicit attitudes measured by self-report measures. Such automatic associations are thought to occur rapidly and to evade voluntary control. However, whether or not such indirect tests actually reflect automatic associations is difficult to validate. Electroencephalography´s superior time resolution enables to differentiate between highly automatic compared to more elaborate processing stages. We therefore examined on which processing stages cortical differences between negative or positive attitudes to doping occur, and whether or not these differences can be related to BIAT scores. We tested 42 university students (31 females, 24.43 ± 3.17 years old, who were requested to complete a brief doping IAT (BIAT on attitudes towards doping. Cerebral activity during doping BIAT completion was assessed using high-density EEG. Behaviorally, participants D-scores exhibited negative attitudes towards doping, represented by faster reaction times in the doping + dislike pairing task. Event-related potentials (ERPs revealed earliest effects between 200 and 300ms. Here, a relatively larger occipital positivity was found for the doping + dislike pairing task. Further, in the LPP time range between 400 and 600ms a larger late positive potential was found for the doping + dislike pairing task over central regions. These LPP amplitude differences were successfully predicting participants´ BIAT D-scores.Results indicate that event-related potentials differentiate between positive and negative doping attitudes at stages of mid-latency. However, it seems that IAT scores can be predicted only by

  20. Conformal symmetry inheritance in null fluid spacetimes

    CERN Document Server

    Tupper, B O J; Hall, G S; Coley, Alan A; Carot, J

    2003-01-01

    We define inheriting conformal Killing vectors for null fluid spacetimes and find the maximum dimension of the associated inheriting Lie algebra. We show that for non-conformally flat null fluid spacetimes, the maximum dimension of the inheriting algebra is seven and for conformally flat null fluid spacetimes the maximum dimension is eight. In addition, it is shown that there are two distinct classes of non-conformally flat generalized plane wave spacetimes which possess the maximum dimension, and one class in the conformally flat case.

  1. Conformal symmetry inheritance in null fluid spacetimes

    Energy Technology Data Exchange (ETDEWEB)

    Tupper, B O J [Department of Mathematics and Statistics, University of New Brunswick, Fredericton, New Brunswick E3B 5A3 (Canada); Keane, A J [Department of Physics and Astronomy, University of Glasgow, Glasgow G12 8QQ (United Kingdom); Hall, G S [Department of Mathematical Sciences, University of Aberdeen, Dunbar Street, Aberdeen AB24 3UE (United Kingdom); Coley, A A [Department of Mathematics and Statistics, Dalhousie University, Halifax, Nova Scotia B3H 3J5 (Canada); Carot, J [Department de Fisica, Universitat de les Illes Balears, E-07071 Palma de Mallorca (Spain)

    2003-03-07

    We define inheriting conformal Killing vectors for null fluid spacetimes and find the maximum dimension of the associated inheriting Lie algebra. We show that for non-conformally flat null fluid spacetimes, the maximum dimension of the inheriting algebra is seven and for conformally flat null fluid spacetimes the maximum dimension is eight. In addition, it is shown that there are two distinct classes of non-conformally flat generalized plane wave spacetimes which possess the maximum dimension, and one class in the conformally flat case.

  2. Families and degenerations of conformal field theories

    International Nuclear Information System (INIS)

    In this work, moduli spaces of conformal field theories are investigated. In the first part, moduli spaces corresponding to current-current deformation of conformal field theories are constructed explicitly. For WZW models, they are described in detail, and sigma model realizations of the deformed WZW models are presented. The second part is devoted to the study of boundaries of moduli spaces of conformal field theories. For this purpose a notion of convergence of families of conformal field theories is introduced, which admits certain degenerated conformal field theories to occur as limits. To such a degeneration of conformal field theories, a degeneration of metric spaces together with additional geometric structures can be associated, which give rise to a geometric interpretation. Boundaries of moduli spaces of toroidal conformal field theories, orbifolds thereof and WZW models are analyzed. Furthermore, also the limit of the discrete family of Virasoro minimal models is investigated. (orig.)

  3. Families and degenerations of conformal field theories

    Energy Technology Data Exchange (ETDEWEB)

    Roggenkamp, D.

    2004-09-01

    In this work, moduli spaces of conformal field theories are investigated. In the first part, moduli spaces corresponding to current-current deformation of conformal field theories are constructed explicitly. For WZW models, they are described in detail, and sigma model realizations of the deformed WZW models are presented. The second part is devoted to the study of boundaries of moduli spaces of conformal field theories. For this purpose a notion of convergence of families of conformal field theories is introduced, which admits certain degenerated conformal field theories to occur as limits. To such a degeneration of conformal field theories, a degeneration of metric spaces together with additional geometric structures can be associated, which give rise to a geometric interpretation. Boundaries of moduli spaces of toroidal conformal field theories, orbifolds thereof and WZW models are analyzed. Furthermore, also the limit of the discrete family of Virasoro minimal models is investigated. (orig.)

  4. Machine learning estimates of natural product conformational energies.

    Directory of Open Access Journals (Sweden)

    Matthias Rupp

    2014-01-01

    Full Text Available Machine learning has been used for estimation of potential energy surfaces to speed up molecular dynamics simulations of small systems. We demonstrate that this approach is feasible for significantly larger, structurally complex molecules, taking the natural product Archazolid A, a potent inhibitor of vacuolar-type ATPase, from the myxobacterium Archangium gephyra as an example. Our model estimates energies of new conformations by exploiting information from previous calculations via Gaussian process regression. Predictive variance is used to assess whether a conformation is in the interpolation region, allowing a controlled trade-off between prediction accuracy and computational speed-up. For energies of relaxed conformations at the density functional level of theory (implicit solvent, DFT/BLYP-disp3/def2-TZVP, mean absolute errors of less than 1 kcal/mol were achieved. The study demonstrates that predictive machine learning models can be developed for structurally complex, pharmaceutically relevant compounds, potentially enabling considerable speed-ups in simulations of larger molecular structures.

  5. Higgs Triplet Model with Classically Conformal Invariance

    CERN Document Server

    Okada, Hiroshi; Yagyu, Kei

    2015-01-01

    We discuss an extension of the minimal Higgs triplet model with a classically conformal invariance and with a gauged $U(1)_{B-L}$ symmetry. In our scenario, tiny masses of neutrinos are generated by a hybrid contribution from the type-I and type-II seesaw mechanisms. The shape of the Higgs potential at low energies is determined by solving one-loop renormalization group equations for all the scalar quartic couplings with a set of initial values of parameters at the Planck scale. We find a successful set of the parameters in which the $U(1)_{B-L}$ symmetry is radiatively broken via the Coleman-Weinberg mechanism at the ${\\cal O}$(10) TeV scale, and the electroweak symmetry breaking is also triggered by the $U(1)_{B-L}$ breaking. Under this configuration, we can predict various low energy observables such as the mass spectrum of extra Higgs bosons, and the mixing angles. Furthermore, using these predicted mass parameters, we obtain upper limits on Yukawa couplings among an isospin triplet Higgs field and lepton...

  6. Improving reservoir conformance using gelled polymer systems

    Energy Technology Data Exchange (ETDEWEB)

    Green, D.W.; Willhite, G.P.

    1993-04-09

    The general objectives are to (1) to identify and develop gelled polymer systems which have potential to improve reservoir conformance of fluid displacement processes, (2) to determine the performance of these systems in bulk and in porous media, and (3) to develop methods to predict the capability of these systems to recover oil from petroleum reservoirs. This work focuses on three types of gel systems - an aqueous polysaccharide (KUSPI) system that gels as a function of pH, the chromium-based system where polyacrylamide and xanthan are crosslinked by CR(III) and an organic crosslinked system. Development of the KUSPI system and evaluation and identification of a suitable organic crosslinked system will be done. The laboratory research is directed at the fundamental understanding of the physics and chemistry of the gelation process in bulk form and in porous media. This knowledge will be used to develop conceptual and mathematical models of the gelation process. Mathematical models will then be extended to predict the performance of gelled polymer treatments in oil reservoirs. Accomplishments for this period are presented for the following tasks: development and selection of gelled polymer systems, physical and chemical characterization of gel systems; and mathematical modeling of gel systems.

  7. Automatic Radiation Monitoring in Slovenia

    International Nuclear Information System (INIS)

    Full text: The automatic radiation monitoring system in Slovenia started in early nineties and now it comprises measurements of: 1. External gamma radiation: For the time being there are forty-three probes with GM tubes integrated into a common automatic network, operated at the SNSA. The probes measure dose rate in 30 minute intervals. 2. Aerosol radioactivity: Three automatic aerosol stations measure the concentration of artificial alpha and beta activity in the air, gamma emitting radionuclides, radioactive iodine 131 in the air (in all chemical forms, - natural radon and thoron progeny, 3. Radon progeny concentration: Radon progeny concentration is measured hourly and results are displayed as the equilibrium equivalent concentrations (EEC), 4. Radioactive deposition measurements: As a support to gamma dose rate measurements - the SNSA developed and installed an automatic measuring station for surface contamination equipped with gamma spectrometry system (with 3x3' NaI(Tl) detector). All data are transferred through the different communication pathways to the SNSA. They are collected in 30 minute intervals. Within these intervals the central computer analyses and processes the collected data, and creates different reports. Every month QA/QC analysis of data is performed, showing the statistics of acquisition errors and availability of measuring results. All results are promptly available at the our WEB pages. The data are checked and daily sent to the EURDEP system at Ispra (Italy) and also to the Austrian, Croatian and Hungarian authorities. (author)

  8. Automatic Identification of Metaphoric Utterances

    Science.gov (United States)

    Dunn, Jonathan Edwin

    2013-01-01

    This dissertation analyzes the problem of metaphor identification in linguistic and computational semantics, considering both manual and automatic approaches. It describes a manual approach to metaphor identification, the Metaphoricity Measurement Procedure (MMP), and compares this approach with other manual approaches. The dissertation then…

  9. Automatically Preparing Safe SQL Queries

    Science.gov (United States)

    Bisht, Prithvi; Sistla, A. Prasad; Venkatakrishnan, V. N.

    We present the first sound program source transformation approach for automatically transforming the code of a legacy web application to employ PREPARE statements in place of unsafe SQL queries. Our approach therefore opens the way for eradicating the SQL injection threat vector from legacy web applications.

  10. The Automatic Measurement of Targets

    DEFF Research Database (Denmark)

    Höhle, Joachim

    1997-01-01

    The automatic measurement of targets is demonstrated by means of a theoretical example and by an interactive measuring program for real imagery from a réseau camera. The used strategy is a combination of two methods: the maximum correlation coefficient and the correlation in the subpixel range...

  11. Automatic quantification of iris color

    DEFF Research Database (Denmark)

    Christoffersen, S.; Harder, Stine; Andersen, J. D.;

    2012-01-01

    An automatic algorithm to quantify the eye colour and structural information from standard hi-resolution photos of the human iris has been developed. Initially, the major structures in the eye region are identified including the pupil, iris, sclera, and eyelashes. Based on this segmentation, the ...

  12. Automatic Association of News Items.

    Science.gov (United States)

    Carrick, Christina; Watters, Carolyn

    1997-01-01

    Discussion of electronic news delivery systems and the automatic generation of electronic editions focuses on the association of related items of different media type, specifically photos and stories. The goal is to be able to determine to what degree any two news items refer to the same news event. (Author/LRW)

  13. Automatic milking : a better understanding

    NARCIS (Netherlands)

    Meijering, A.; Hogeveen, H.; Koning, de C.J.A.M.

    2004-01-01

    In 2000 the book Robotic Milking, reflecting the proceedings of an International Symposium which was held in The Netherlands came out. At that time, commercial introduction of automatic milking systems was no longer obstructed by technological inadequacies. Particularly in a few west-European countr

  14. From Conformal to Einstein Gravity

    CERN Document Server

    Anastasiou, Giorgos

    2016-01-01

    We provide a simple derivation of the equivalence between Einstein and Conformal Gravity (CG) with Neumann boundary conditions given by Maldacena. As Einstein spacetimes are Bach flat, a generic solution to CG would contain both Einstein and non-Einstein part. Using this decomposition of the spacetime curvature in the Weyl tensor, makes manifest the equivalence between the two theories, both at the level of the action and the variation of it. As a consequence, we show that the on-shell action for Critical Gravity in four dimensions is given uniquely in terms of the Bach tensor.

  15. Toward TeV Conformality

    Energy Technology Data Exchange (ETDEWEB)

    Appelquist, T; Avakian, A; Babich, R; Brower, R C; Cheng, M; Clark, M A; Cohen, S D; Fleming, G T; Kiskis, J; Neil, E T; Osborn, J C; Rebbi, C; Schaich, D; Soltz, R; Vranas, P

    2009-11-30

    We study the chiral condensate <{bar {psi}}{psi}> for an SU(3) gauge theory with N{sub f} massless Dirac fermions in the fundamental representation when N{sub f} is increased from 2 to 6. For N{sub f} = 2, our lattice simulations of <{bar {psi}}{psi}>/F{sup 3}, where F is the Nambu-Goldstone-boson decay constant, agree with the measured QCD value. For N{sub f} = 6, this ratio shows significant enhancement, presaging an even larger enhancement anticipated as N{sub f} increases further, toward the critical value for transition from confinement to infrared conformality.

  16. Toward TeV Conformality

    International Nuclear Information System (INIS)

    We study the chiral properties of an SU(3) gauge theory with Nf massless Dirac fermions in the fundamental representation when Nf is increased from 2 to 6. For Nf=2, our lattice simulations lead to a value of /F3, where F is the Nambu-Goldstone-boson decay constant and is the chiral condensate, which agrees with the measured QCD value. For Nf=6, this ratio shows significant enhancement, presaging an even larger enhancement anticipated as Nf increases further, toward the critical value for transition from confinement to infrared conformality.

  17. New automatic minidisk infiltrometer: design and testing

    Directory of Open Access Journals (Sweden)

    Klípa Vladimír

    2015-06-01

    Full Text Available Soil hydraulic conductivity is a key parameter to predict water flow through the soil profile. We have developed an automatic minidisk infiltrometer (AMI to enable easy measurement of unsaturated hydraulic conductivity using the tension infiltrometer method in the field. AMI senses the cumulative infiltration by recording change in buoyancy force acting on a vertical solid bar fixed in the reservoir tube of the infiltrometer. Performance of the instrument was tested in the laboratory and in two contrasting catchments at three sites with different land use. Hydraulic conductivities determined using AMI were compared with earlier manually taken readings. The results of laboratory testing demonstrated high accuracy and robustness of the AMI measurement. Field testing of AMI proved the suitability of the instrument for use in the determination of sorptivity and near saturated hydraulic conductivity

  18. Decoupling of crystalline and conformational degrees of freedom in lipid monolayers

    DEFF Research Database (Denmark)

    Ipsen, John Hjorth; Mouritsen, Ole G.; Zuckermann, Martin J.

    1989-01-01

    A theoretical study is performed on a microscopic interaction model which describes the transitions between liquid and solid phases of lipid monolayers spread on air/water interfaces. The model accounts for condensation in terms of acyl-chain conformational degrees of freedom as well as in terms...... of condensation processes and effects on the phase behavior due to decoupling of crystalline and conformational order parameters. In the case of decoupling, the model predicts that the high-pressure solid-conformationally ordered phase is separated from the low-pressure liquid-conformationally disordered phase...... of the experimentally observed isotherms of lipid monolayer phase behavior. It is pointed out that cholesterol, which promotes lipid-chain conformational order, has a unique capacity of acting as a `crystal breaker' in the solid monolayer phases and therefore provides a molecular mechanism for decoupling crystalline...

  19. Dosimetric Evaluation of Automatic Segmentation for Adaptive IMRT for Head-and-Neck Cancer

    International Nuclear Information System (INIS)

    Purpose: Adaptive planning to accommodate anatomic changes during treatment requires repeat segmentation. This study uses dosimetric endpoints to assess automatically deformed contours. Methods and Materials: Sixteen patients with head-and-neck cancer had adaptive plans because of anatomic change during radiotherapy. Contours from the initial planning computed tomography (CT) were deformed to the mid-treatment CT using an intensity-based free-form registration algorithm then compared with the manually drawn contours for the same CT using the Dice similarity coefficient and an overlap index. The automatic contours were used to create new adaptive plans. The original and automatic adaptive plans were compared based on dosimetric outcomes of the manual contours and on plan conformality. Results: Volumes from the manual and automatic segmentation were similar; only the gross tumor volume (GTV) was significantly different. Automatic plans achieved lower mean coverage for the GTV: V95: 98.6 ± 1.9% vs. 89.9 ± 10.1% (p = 0.004) and clinical target volume: V95: 98.4 ± 0.8% vs. 89.8 ± 6.2% (p 3 of the spinal cord 39.9 ± 3.7 Gy vs. 42.8 ± 5.4 Gy (p = 0.034), but no difference for the remaining structures. Conclusions: Automatic segmentation is not robust enough to substitute for physician-drawn volumes, particularly for the GTV. However, it generates normal structure contours of sufficient accuracy when assessed by dosimetric end points.

  20. A conformal block Farey tail

    CERN Document Server

    Maloney, Alexander; Ng, Gim Seng

    2016-01-01

    We investigate the constraints of crossing symmetry on CFT correlation functions. Four point conformal blocks are naturally viewed as functions on the upper-half plane, on which crossing symmetry acts by PSL(2,Z) modular transformations. This allows us to construct a unique, crossing symmetric function out of a given conformal block by averaging over PSL(2,Z). In some two dimensional CFTs the correlation functions are precisely equal to the modular average of the contributions of a finite number of light states. For example, in the two dimensional Ising and tri-critical Ising model CFTs, the correlation functions of identical operators are equal to the PSL(2,Z) average of the Virasoro vacuum block; this determines the 3 point function coefficients uniquely in terms of the central charge. The sum over PSL(2,Z) in CFT2 has a natural AdS3 interpretation as a sum over semi-classical saddle points, which describe particles propagating along rational tangles in the bulk. We demonstrate this explicitly for the corre...

  1. Conformal inflation coupled to matter

    International Nuclear Information System (INIS)

    We formulate new conformal models of inflation and dark energy which generalise the Higgs-Dilaton scenario. We embed these models in unimodular gravity whose effect is to break scale invariance in the late time Universe. In the early Universe, inflation occurs close to a maximum of both the scalar potential and the scalar coupling to the Ricci scalar in the Jordan frame. At late times, the dilaton, which decouples from the dynamics during inflation, receives a potential term from unimodular gravity and leads to the acceleration of the Universe. We address two central issues in this scenario. First we show that the Damour-Polyalov mechanism, when non-relativistic matter is present prior to the start of inflation, sets the initial conditions for inflation at the maximum of the scalar potential. We then show that conformal invariance implies that matter particles are not coupled to the dilaton in the late Universe at the classical level. When fermions acquire masses at low energy, scale invariance is broken and quantum corrections induce a coupling between the dilaton and matter which is still small enough to evade the gravitational constraints in the solar system

  2. Holography and Conformal Anomaly Matching

    CERN Document Server

    Cabo-Bizet, Alejandro; Narain, K S

    2013-01-01

    We discuss various issues related to the understanding of the conformal anomaly matching in CFT from the dual holographic viewpoint. First, we act with a PBH diffeomorphism on a generic 5D RG flow geometry and show that the corresponding on-shell bulk action reproduces the Wess-Zumino term for the dilaton of broken conformal symmetry, with the expected coefficient aUV-aIR. Then we consider a specific 3D example of RG flow whose UV asymptotics is normalizable and admits a 6D lifting. We promote a modulus \\rho appearing in the geometry to a function of boundary coordinates. In a 6D description {\\rho} is the scale of an SU(2) instanton. We determine the smooth deformed background up to second order in the space-time derivatives of \\rho and find that the 3D on-shell action reproduces a boundary kinetic term for the massless field \\tau= log(\\rho) with the correct coefficient \\delta c=cUV-cIR. We further analyze the linearized fluctuations around the deformed background geometry and compute the one-point functions ...

  3. Conformal anomaly c-coefficients of superconformal 6d theories

    CERN Document Server

    Beccaria, Matteo

    2015-01-01

    We propose general relations between the conformal anomaly and the chiral (R-symmetry and gravitational) anomaly coefficients in 6d (1,0) superconformal theories. The suggested expressions for the three type B conformal anomaly c-coefficients complement the expression for the type A anomaly a-coefficient found in arXiv:1506.03807. We check them on several examples -- the standard (1,0) hyper and tensor multiplets as well as some higher derivative short multiplets containing vector fields that generalize the superconformal 6d vector multiplet discussed in arXiv:1506.08727. We also consider a family of higher derivative superconformal (2,0) 6d multiplets associated to 7d multiplets in the KK spectrum of 11d supergravity compactified on S^4. In particular, we prove that (2,0) 6d conformal supergravity coupled to 26 tensor multiplets is free of all chiral and conformal anomalies. We discuss some interacting (1,0) superconformal theories, predicting the c-coefficients for the "E-string" theory on multiple M5-brane...

  4. Necessary Condition for Emergent Symmetry from the Conformal Bootstrap

    Science.gov (United States)

    Nakayama, Yu; Ohtsuki, Tomoki

    2016-09-01

    We use the conformal bootstrap program to derive the necessary conditions for emergent symmetry enhancement from discrete symmetry (e.g., Zn ) to continuous symmetry [e.g., U (1 )] under the renormalization group flow. In three dimensions, in order for Z2 symmetry to be enhanced to U (1 ) symmetry, the conformal bootstrap program predicts that the scaling dimension of the order parameter field at the infrared conformal fixed point must satisfy Δ1>1.08 . We also obtain the similar necessary conditions for Z3 symmetry with Δ1>0.580 and Z4 symmetry with Δ1>0.504 from the simultaneous conformal bootstrap analysis of multiple four-point functions. As applications, we show that our necessary conditions impose severe constraints on the nature of the chiral phase transition in QCD, the deconfinement criticality in Néel valence bond solid transitions, and anisotropic deformations in critical O (n ) models. We prove that some fixed points proposed in the literature are unstable under the perturbation that cannot be forbidden by the discrete symmetry. In these situations, the second-order phase transition with enhanced symmetry cannot happen.

  5. Engineering a hyper-catalytic enzyme by photo-activated conformation modulation

    Energy Technology Data Exchange (ETDEWEB)

    Agarwal, Pratul K [ORNL

    2012-01-01

    Enzyme engineering for improved catalysis has wide implications. We describe a novel chemical modification of Candida antarctica lipase B that allows modulation of the enzyme conformation to promote catalysis. Computational modeling was used to identify dynamical enzyme regions that impact the catalytic mechanism. Surface loop regions located distal to active site but showing dynamical coupling to the reaction were connected by a chemical bridge between Lys136 and Pro192, containing a derivative of azobenzene. The conformational modulation of the enzyme was achieved using two sources of light that alternated the azobenzene moiety in cis and trans conformations. Computational model predicted that mechanical energy from the conformational fluctuations facilitate the reaction in the active-site. The results were consistent with predictions as the activity of the engineered enzyme was found to be enhanced with photoactivation. Preliminary estimations indicate that the engineered enzyme achieved 8-52 fold better catalytic activity than the unmodulated enzyme.

  6. Weyl-Conformally Invariant p-Brane Theories

    CERN Document Server

    Guendelman, E; Nissimov, E; Pacheva, S; Guendelman, Eduardo; Kaganovich, Alexander; Nissimov, Emil; Pacheva, Svetlana

    2005-01-01

    We discuss in some detail the properties of a novel class of Weyl-conformally invariant p-brane theories which describe intrinsically light-like branes for any odd world-volume dimension and whose dynamics significantly differs from that of the ordinary (conformally non-invariant) Nambu-Goto p-branes. We present explicit solutions of the WILL-brane (Weyl-Invariant Light-Like brane) equations of motion in various gravitational backgrounds of physical relevance exhibiting the following new phenomena: (i) In spherically symmetric static backgrounds the WILL-brane automatically positions itself on (materializes) the event horizon of the corresponding black hole solutions, thus providing an explicit dynamical realization of the membrane paradigm in black hole physics; (ii) In product spaces (of interest in Kaluza-Klein context) the WILL-brane wrappes non-trivially around the compact (internal) dimensions and moves as a whole with the speed of light in the non-compact (space-time) dimensions.

  7. To bend or not to bend – are heteroatom interactions within conjugated molecules effective in dictating conformation and planarity?

    KAUST Repository

    Conboy, Gary

    2016-04-26

    We consider the roles of heteroatoms (mainly nitrogen, the halogens and the chalcogens) in dictating the conformation of linear conjugated molecules and polymers through non-covalent intramolecular interactions. Whilst hydrogen bonding is a competitive and sometimes more influential interaction, we provide unambiguous evidence that heteroatoms are able to determine the conformation of such materials with reasonable predictability.

  8. An Automatic Proof of Euler's Formula

    Directory of Open Access Journals (Sweden)

    Jun Zhang

    2005-05-01

    Full Text Available In this information age, everything is digitalized. The encoding of functions and the automatic proof of functions are important. This paper will discuss the automatic calculation for Taylor expansion coefficients, as an example, it can be applied to prove Euler's formula automatically.

  9. Self-Compassion and Automatic Thoughts

    Science.gov (United States)

    Akin, Ahmet

    2012-01-01

    The aim of this research is to examine the relationships between self-compassion and automatic thoughts. Participants were 299 university students. In this study, the Self-compassion Scale and the Automatic Thoughts Questionnaire were used. The relationships between self-compassion and automatic thoughts were examined using correlation analysis…

  10. Modeling the Conformation-Specific Infrared Spectra of N-Alkylbenzenes

    Science.gov (United States)

    Tabor, Daniel P.; Sibert, Edwin; Hewett, Daniel M.; Korn, Joseph A.; Zwier, Timothy S.

    2016-06-01

    Conformation-specific UV-IR double resonance spectra are presented for n-alkylbenzenes. With the aid of a local mode Hamiltonian that includes the effects of stretch-bend Fermi coupling, the spectra of ethyl, n-propyl, and n-butylbenzene are assigned to individual conformers. These molecules allow for further development of the work on a first principles method for calculating alkyl stretch spectra. Due to the consistency of the anharmonic couplings from conformer to conformer, construction of the model Hamiltonian for a given conformer only requires a harmonic frequency calculation at the conformer's minimum geometry as an input. The model Hamiltonian can be parameterized with either density functional theory or MP2 electronic structure calculations. The relative strengths and weaknesses of these methods are evaluated, including their predictions of the relative energetics of the conformers. Finally, the IR spectra for conformers that have the alkyl chain bend back and interact with the π cloud of the benzene ring are modeled.

  11. Theoretical Studies on Two Possible Conformers of TNDAIW at Hartree-Fock Level

    Institute of Scientific and Technical Information of China (English)

    WU Yu-kai; OU Yu-xiang; LIU Zhi-guo; MENG Zheng; ,LIU Jin-quan; CHEN Bo-ren

    2005-01-01

    Tetranitrodiazidoacetylhexaazaisowurtzitane (TNDAIW) is a novel polyazapolycyclic caged polyazidonitramine explosive first synthesized in our laboratory. Two possible conformers of TNDAIW with Cs symmetry were fully optimized using the HF/6-31G(d) level of theory. TNDAIW with the optimized geometries probably exists, and is predicted to be more stable than epsilon-hexanitrohexaazoisowurtzitane (epsilon-CL-20) based on the lengths of N-N, C-C and C-N bonds. The impact and shock sensitivities are lower for the possible conformers of TNDAIW than those for epsilon-CL-20. TNDAIW with the optimized possible conformers is estimated to be a promising novel high energy density explosive.

  12. Conformation of comb liquid crystal polymers by neutron small angle scattering

    International Nuclear Information System (INIS)

    A review is made of the direct information obtained by small angle neutron scattering about the anisotropy of the components parallel and perpendicular to the orienting magnetic field of the radius of gyration of comb like liquid crystal polymers. The behaviour of the conformation versus temperature is reported for several samples. Until now all samples show an oblate conformation in the smectic phase and probably the whole range of the nematic phase. The results are compared with the available theoretical predictions

  13. Conformal Invariance of Black Hole Temperature

    OpenAIRE

    Jacobson, Ted; Kang, Gungwon

    1993-01-01

    It is shown that the surface gravity and temperature of a stationary black hole are invariant under conformal transformations of the metric that are the identity at infinity. More precisely, we find a conformal invariant definition of the surface gravity of a conformal Killing horizon that agrees with the usual definition(s) for a true Killing horizon and is proportional to the temperature as defined by Hawking radiation. This result is reconciled with the intimate relation between the trace ...

  14. A conformable active matrix LED display

    OpenAIRE

    Tripathi, Ashutosh; Smits, Edsger; van der Steen, Jan-Laurens; Cauwe, Maarten; Verplancke, Rik; Myny, Kris; Maas, Joris; Kusters, Roel; Sabik, Sami; Murata, Mitsuhiro; Tomita, Yoshihiro; Ohmae, Hideki; van den Brand, Jeroen; Gelinck, Gerwin

    2015-01-01

    Conformable and stretchable displays can be integrated on complex surfaces. Such a display can assume the shape of a conformed surface by simultaneous multi-dimensional stretching and bending. Such technology provides new opportunities in the field of display applications, for example wearable displays integrated or embedded in a textile or onto complex surfaces in automotive interiors. In this work we present a conformable active matrix display using LEDs mounted on an amorphous Indium-Galli...

  15. Exact results in defect conformal field theories

    Energy Technology Data Exchange (ETDEWEB)

    Lauria, Edoardo [KU Leuven, Institute for Theoretical Physics (Belgium)

    2016-04-15

    Defect Conformal Field Theories describe critical points of Quantum Field Theories excited or modified in the neighbourhood of a large p-dimensional submanifold. We elucidate the constraints of conformal invariance on correlation functions and we provide both recurrence relations, and in some cases exact results, for the conformal blocks with scalar external operators. (copyright 2016 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  16. Conformational changes in glycine tri- and hexapeptide

    DEFF Research Database (Denmark)

    Yakubovich, Alexander V.; Solov'yov, Ilia; Solov'yov, Andrey V.;

    2006-01-01

    conformations and calculated the energy barriers for transitions between them. Using a thermodynamic approach, we have estimated the times of the characteristic transitions between these conformations. The results of our calculations have been compared with those obtained by other theoretical methods...... also investigated the influence of the secondary structure of polypeptide chains on the formation of the potential energy landscape. This analysis has been performed for the sheet and the helix conformations of chains of six amino acids....

  17. Multiple conformations of proteins in native state

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    Examples of protein sequences that can adopt multiple native states are recently accumulated. Characterization of the protein multiple conformations will have important implications for our understanding of the relationship between structure and function, and their folding kinetics. In present review, the experimental evidence for the existence of multiple conformations in the native state of proteins, the molecular basis and the biological significance of multiple conformations of proteins are focused.

  18. Finite Conformal Quantum Gravity and Nonsingular Spacetimes

    OpenAIRE

    Modesto, Leonardo; Rachwal, Leslaw

    2016-01-01

    We explicitly prove that a class of finite quantum gravitational theories (in odd as well as in even dimension) is actually a range of anomaly-free conformally invariant theories in the spontaneously broken phase of the conformal Weyl symmetry. At classical level we show how the Weyl conformal invariance is likely able to tame the spacetime singularities that plague not only Einstein gravity, but also local and weakly non-local higher derivative theories. This latter statement is rigorously p...

  19. TASI Lectures on the Conformal Bootstrap

    CERN Document Server

    Simmons-Duffin, David

    2016-01-01

    These notes are from courses given at TASI and the Advanced Strings School in summer 2015. Starting from principles of quantum field theory and the assumption of a traceless stress tensor, we develop the basics of conformal field theory, including conformal Ward identities, radial quantization, reflection positivity, the operator product expansion, and conformal blocks. We end with an introduction to numerical bootstrap methods, focusing on the 2d and 3d Ising models.

  20. Conformal Invariance in Classical Field Theory

    OpenAIRE

    Grigore, D. R.

    1993-01-01

    A geometric generalization of first-order Lagrangian formalism is used to analyse a conformal field theory for an arbitrary primary field. We require that global conformal transformations are Noetherian symmetries and we prove that the action functional can be taken strictly invariant with respect to these transformations. In other words, there does not exists a "Chern-Simons" type Lagrangian for a conformally invariant Lagrangian theory.

  1. Lattice models and conformal field theories

    International Nuclear Information System (INIS)

    Theoretical studies concerning the connection between critical physical systems and the conformal theories are reviewed. The conformal theory associated to a critical (integrable) lattice model is derived. The obtention of the central charge, critical exponents and torus partition function, using renormalization group arguments, is shown. The quantum group structure, in the integrable lattice models, and the theory of Visaro algebra representations are discussed. The relations between off-critical integrable models and conformal theories, in finite geometries, are studied

  2. Automatic schema evolution in Root

    International Nuclear Information System (INIS)

    ROOT version 3 (spring 2001) supports automatic class schema evolution. In addition this version also produces files that are self-describing. This is achieved by storing in each file a record with the description of all the persistent classes in the file. Being self-describing guarantees that a file can always be read later, its structure browsed and objects inspected, also when the library with the compiled code of these classes is missing. The schema evolution mechanism supports the frequent case when multiple data sets generated with many different class versions must be analyzed in the same session. ROOT supports the automatic generation of C++ code describing the data objects in a file

  3. Automatic spikes detection in seismogram

    Institute of Scientific and Technical Information of China (English)

    王海军; 靳平; 刘贵忠

    2003-01-01

    @@ Data processing for seismic network is very complex and fussy, because a lot of data is recorded in seismic network every day, which make it impossible to process these data all by manual work. Therefore, seismic data should be processed automatically to produce a initial results about events detection and location. Afterwards, these results are reviewed and modified by analyst. In automatic processing data quality checking is important. There are three main problem data thatexist in real seismic records, which include: spike, repeated data and dropouts. Spike is defined as isolated large amplitude point; the other two problem datahave the same features that amplitude of sample points are uniform in a interval. In data quality checking, the first step is to detect and statistic problem data in a data segment, if percent of problem data exceed a threshold, then the whole data segment is masked and not be processed in the later process.

  4. Physics of Automatic Target Recognition

    CERN Document Server

    Sadjadi, Firooz

    2007-01-01

    Physics of Automatic Target Recognition addresses the fundamental physical bases of sensing, and information extraction in the state-of-the art automatic target recognition field. It explores both passive and active multispectral sensing, polarimetric diversity, complex signature exploitation, sensor and processing adaptation, transformation of electromagnetic and acoustic waves in their interactions with targets, background clutter, transmission media, and sensing elements. The general inverse scattering, and advanced signal processing techniques and scientific evaluation methodologies being used in this multi disciplinary field will be part of this exposition. The issues of modeling of target signatures in various spectral modalities, LADAR, IR, SAR, high resolution radar, acoustic, seismic, visible, hyperspectral, in diverse geometric aspects will be addressed. The methods for signal processing and classification will cover concepts such as sensor adaptive and artificial neural networks, time reversal filt...

  5. Automatic Schema Evolution in Root

    Institute of Scientific and Technical Information of China (English)

    ReneBrun; FonsRademakers

    2001-01-01

    ROOT version 3(spring 2001) supports automatic class schema evolution.In addition this version also produces files that are self-describing.This is achieved by storing in each file a record with the description of all the persistent classes in the file.Being self-describing guarantees that a file can always be read later,its structure browsed and objects inspected.also when the library with the compiled code of these classes is missing The schema evolution mechanism supports the frequent case when multiple data sets generated with many different class versions must be analyzed in the same session.ROOT supports the automatic generation of C++ code describing the data objects in a file.

  6. Automatic Validation of Protocol Narration

    DEFF Research Database (Denmark)

    Bodei, Chiara; Buchholtz, Mikael; Degano, Pierpablo;

    2003-01-01

    We perform a systematic expansion of protocol narrations into terms of a process algebra in order to make precise some of the detailed checks that need to be made in a protocol. We then apply static analysis technology to develop an automatic validation procedure for protocols. Finally, we...... demonstrate that these techniques suffice for identifying a number of authentication flaws in symmetric key protocols such as Needham-Schroeder, Otway-Rees, Yahalom and Andrew Secure RPC....

  7. The Automaticity of Social Life

    OpenAIRE

    Bargh, John A.; Williams, Erin L.

    2006-01-01

    Much of social life is experienced through mental processes that are not intended and about which one is fairly oblivious. These processes are automatically triggered by features of the immediate social environment, such as the group memberships of other people, the qualities of their behavior, and features of social situations (e.g., norms, one's relative power). Recent research has shown these nonconscious influences to extend beyond the perception and interpretation of the social world to ...

  8. Automatically-Programed Machine Tools

    Science.gov (United States)

    Purves, L.; Clerman, N.

    1985-01-01

    Software produces cutter location files for numerically-controlled machine tools. APT, acronym for Automatically Programed Tools, is among most widely used software systems for computerized machine tools. APT developed for explicit purpose of providing effective software system for programing NC machine tools. APT system includes specification of APT programing language and language processor, which executes APT statements and generates NC machine-tool motions specified by APT statements.

  9. Automatic Generation of Technical Documentation

    OpenAIRE

    Reiter, Ehud; Mellish, Chris; Levine, John

    1994-01-01

    Natural-language generation (NLG) techniques can be used to automatically produce technical documentation from a domain knowledge base and linguistic and contextual models. We discuss this application of NLG technology from both a technical and a usefulness (costs and benefits) perspective. This discussion is based largely on our experiences with the IDAS documentation-generation project, and the reactions various interested people from industry have had to IDAS. We hope that this summary of ...

  10. Annual review in automatic programming

    CERN Document Server

    Halpern, Mark I; Bolliet, Louis

    2014-01-01

    Computer Science and Technology and their Application is an eight-chapter book that first presents a tutorial on database organization. Subsequent chapters describe the general concepts of Simula 67 programming language; incremental compilation and conversational interpretation; dynamic syntax; the ALGOL 68. Other chapters discuss the general purpose conversational system for graphical programming and automatic theorem proving based on resolution. A survey of extensible programming language is also shown.

  11. The Automatic Galaxy Collision Software

    CERN Document Server

    Smith, Beverly J; Pfeiffer, Phillip; Perkins, Sam; Barkanic, Jason; Fritts, Steve; Southerland, Derek; Manchikalapudi, Dinikar; Baker, Matt; Luckey, John; Franklin, Coral; Moffett, Amanda; Struck, Curtis

    2009-01-01

    The key to understanding the physical processes that occur during galaxy interactions is dynamical modeling, and especially the detailed matching of numerical models to specific systems. To make modeling interacting galaxies more efficient, we have constructed the `Automatic Galaxy Collision' (AGC) code, which requires less human intervention in finding good matches to data. We present some preliminary results from this code for the well-studied system Arp 284 (NGC 7714/5), and address questions of uniqueness of solutions.

  12. Automatic validation of numerical solutions

    DEFF Research Database (Denmark)

    Stauning, Ole

    1997-01-01

    This thesis is concerned with ``Automatic Validation of Numerical Solutions''. The basic theory of interval analysis and self-validating methods is introduced. The mean value enclosure is applied to discrete mappings for obtaining narrow enclosures of the iterates when applying these mappings...... of an integral operator and uses interval Bernstein polynomials for enclosing the solution. Two numerical examples are given, using two orders of approximation and using different numbers of discretization points....

  13. Solving conformal wheel-rail rolling contact problems

    Science.gov (United States)

    Vollebregt, Edwin; Segal, Guus

    2014-05-01

    The stresses between railway wheels and rails can be computed using different types of contact models: simplified methods, half-space-based boundary element approaches and finite element models. For conformal contact situations, particularly the contact between flange root and rail gauge corner, none of these models work satisfactorily. Finite element methods are too slow, half-space approaches ignore the effects of conformality, and simplified approaches schematise the elasticity of the material even further. This paper presents a thorough investigation of the conformal wheel-rail rolling contact problem. We use CONTACT's boundary element approach together with numerical influence coefficients, that are computed using the finite element approach. The resulting method is fast and detailed and can be embedded into vehicle system dynamics simulation. The results indicate that the contact area is longer and narrower, with smaller area and reduced stiffness, than is predicted by the half-space approach. The predicted maximum pressures are increased by 30%. Finally the longitudinal and lateral forces changed up to 15% of the Coulomb maximum.

  14. Electromagnetic characterization of conformal antennas

    Science.gov (United States)

    Volakis, John L.; Kempel, Leo C.; Alexanian, Angelos; Jin, J. M.; Yu, C. L.; Woo, Alex C.

    1992-01-01

    The ultimate objective of this project is to develop a new technique which permits an accurate simulation of microstrip patch antennas or arrays with various feed, superstrate and/or substrate configurations residing in a recessed cavity whose aperture is planar, cylindrical or otherwise conformed to the substructure. The technique combines the finite element and boundary integral methods to formulate a system suitable for solution via the conjugate gradient method in conjunction with the fast Fourier transform. The final code is intended to compute both scattering and radiation patterns of the structure with an affordable memory demand. With upgraded capabilities, the four included papers examined the radar cross section (RCS), input impedance, gain, and resonant frequency of several rectangular configurations using different loading and substrate/superstrate configurations.

  15. A conformal model of gravitons

    CERN Document Server

    Donoghue, John F

    2016-01-01

    In the description of general covariance, the vierbein and the Lorentz connection can be treated as independent fundamental fields. With the usual gauge Lagrangian, the Lorentz connection is characterized by an asymptotically free running coupling. When running from high energy, the coupling gets large at a scale which can be called the Planck mass. If the Lorentz connection is confined at that scale, the low energy theory can have the Einstein Lagrangian induced at low energy through dimensional transmutation. However, in general there will be new divergences in such a theory and the Lagrangian basis should be expanded. I construct a conformally invariant model with a larger basis size which potentially may have the same property.

  16. Gravitomagnetic effects in conformal gravity

    CERN Document Server

    Said, Jackson Levi; Adami, Kristian Zarb

    2014-01-01

    Gravitomagnetic effects are characterized by two phenomena: first, the geodetic effect which describes the precession of the spin of a gyroscope in a free orbit around a massive object, second, the Lense-Thirring effect which describes the precession of the orbital plane about a rotating source mass. We calculate both these effects in the fourth-order theory of conformal Weyl gravity for the test case of circular orbits. We show that for the geodetic effect a linear term arises which may be interesting for high radial orbits, whereas for the Lense-Thirring effect the additional term has a diminishing effect for most orbits. Circular orbits are also considered in general leading up to a generalization of Kepler's third law.

  17. Technidilaton at the conformal edge

    Science.gov (United States)

    Hashimoto, Michio; Yamawaki, Koichi

    2011-01-01

    Technidilaton (TD) was proposed long ago in the technicolor near criticality/conformality. To reveal the critical behavior of TD, we explicitly compute the nonperturbative contributions to the scale anomaly ⟨θμμ⟩ and to the technigluon condensate ⟨αGμν2⟩, which are generated by the dynamical mass m of the technifermions. Our computation is based on the (improved) ladder Schwinger-Dyson equation, with the gauge coupling α replaced by the two-loop running coupling α(μ) having the Caswell-Banks-Zaks infrared fixed point α*: α(μ)≃α=α* for the infrared region mHaba-Matsuzaki-Yamawaki. The decoupled TD can be a candidate of dark matter.

  18. Conformal and projective symmetries in Newtonian cosmology

    CERN Document Server

    Duval, Christian; Horvathy, Peter

    2016-01-01

    Definitions of non-relativistic conformal transformations are considered both in the Newton-Cartan and in the Kaluza-Klein-type Eisenhart/Bargmann geometrical frameworks. The symmetry groups that come into play are exemplified by the cosmological, and also the Newton-Hooke solutions of Newton's gravitational field equations. It is shown, in particular, that the maximal symmetry group of the standard cosmological model is isomorphic to the 13-dimensional conformal-Newton-Cartan group whose conformal-Bargmann extension is explicitly worked out. Attention is drawn to the appearance of independent space and time dilations, it contrast with the Schr{\\"o}dinger group or the Conformal Galilei Algebra.

  19. Conformal invariance conserved quantity of Hamilton systems

    Institute of Scientific and Technical Information of China (English)

    Cai Jian-Le; Luo Shao-Kai; Mei Feng-Xiang

    2008-01-01

    This paper studies conformal invariance and comserved quantRies of Hamilton system.The definition and the determining equation of conformal invariance for Hamilton system are provided.The relationship between the conformal invariance and the Lie symmetry are discussed,and the necessary and sufficient condition that the conformal invariance would be the Lie symmetry of the system under the infinitesimal one-parameter transformation group is deduced.It gives the conserved quantities of the system and an example for illustration.

  20. Superintegrability of $d$-dimensional Conformal Blocks

    CERN Document Server

    Isachenkov, Mikhail

    2016-01-01

    We observe that conformal blocks of scalar 4-point functions in a $d$-dimensional conformal field theory can mapped to eigenfunctions of a 2-particle hyperbolic Calogero-Sutherland Hamiltonian. The latter describes two coupled P\\"oschl-Teller particles. Their interaction, whose strength depends smoothly on the dimension $d$, is known to be superintegrable. Our observation enables us to exploit the rich mathematical literature on Calogero-Sutherland models in deriving various results for conformal field theory. These include an explicit construction of conformal blocks in terms of Heckman-Opdam hypergeometric functions and a remarkable duality that relates the blocks of theories in different dimensions.

  1. Rotational Spectroscopy Unveils Eleven Conformers of Adrenaline

    Science.gov (United States)

    Cabezas, C.; Cortijo, V.; Mata, S.; Lopez, J. C.; Alonso, J. L.

    2013-06-01

    Recent improvements in our LA-MB-FTMW instrumentation have allowed the characterization of eleven and eight conformers for the neurotransmitters adrenaline and noradrenaline respectively. The observation of this rich conformational behavior is in accordance with the recent observation of seven conformers for dopamine and in sharp contrast with the conformational reduction proposed for catecholamines. C. Cabezas, I. Peña, J. C. López, J. L. Alonso J. Phys. Chem. Lett. 2013, 4, 486. H. Mitsuda, M. Miyazaki, I. B. Nielsen, P. Carcabal,C. Dedonder, C. Jouvet, S. Ishiuchi, M. Fujii J. Phys. Chem. Lett. 2010, 1, 1130.

  2. Geometric correction of deformed chromosomes for automatic Karyotyping.

    Science.gov (United States)

    Khan, Shadab; DSouza, Alisha; Sanches, João; Ventura, Rodrigo

    2012-01-01

    Automatic Karyotyping is the process of classifying chromosomes from an unordered karyogram into their respective classes to create an ordered karyogram. Automatic karyotyping algorithms typically perform geometrical correction of deformed chromosomes for feature extraction; these features are used by classifier algorithms for classifying the chromosomes. Karyograms of bone marrow cells are known to have poor image quality. An example of such karyograms is the Lisbon-K(1) (LK(1)) dataset that is used in our work. Thus, to correct the geometrical deformation of chromosomes from LK(1), a robust method to obtain the medial axis of the chromosome was necessary. To address this problem, we developed an algorithm that uses the seed points to make a primary prediction. Subsequently, the algorithm computes the distance of boundary from the predicted point, and the gradients at algorithm-specified points on the boundary to compute two auxiliary predictions. Primary prediction is then corrected using auxiliary predictions, and a final prediction is obtained to be included in the seed region. A medial axis is obtained this way, which is further used for geometrical correction of the chromosomes. This algorithm was found capable of correcting geometrical deformations in even highly distorted chromosomes with forked ends.

  3. Stable phantom-energy wormholes admitting conformal motions

    CERN Document Server

    Kuhfittig, Peter K F

    2016-01-01

    It has been argued that wormholes are as good a prediction of Einstein's theory as black holes but the theoretical construction requires a reverse strategy, specifying the desired geometric properties of the wormhole and leaving open the determination of the stress-energy tensor. We begin by confirming an earlier result by the author showing that a complete wormhole solution can be obtained by adopting the equation of state $p=\\omega\\rho$ and assuming that the wormhole admits a one-parameter group of conformal motions. The main purpose of this paper is to use the assumption of conformal symmetry to show that the wormhole is stable to linearized radial perturbations whenever $-1.5<\\omega <-1$.

  4. Conformational Slippage Determines Rotational Frequency in Five-Component Nanorotors.

    Science.gov (United States)

    Samanta, Soumen K; Rana, Anup; Schmittel, Michael

    2016-02-01

    Several five-component nanorotors ROT-3 that rotate at different rates were prepared by adding phenanthrolines of distinct lateral size as brake blocks to the four-component nanorotor ROT-2. The brake blocks interfere with the 180° rotor causing the rotational frequency to drop from 97 kHz to 5 kHz. The effect of the rotating brake blocks on the rotational frequency in ROT-3 is accurately predicted by a nanomechanical model called "conformational slippage". For quantification, the interaction of the brake blocks with the trajectory of the main rotator is gauged based on the number of interfering vs. non-interfering conformations as computed by PM6. PMID:26836349

  5. Development of a System for Automatic Facial Expression Analysis

    Science.gov (United States)

    Diago, Luis A.; Kitaoka, Tetsuko; Hagiwara, Ichiro

    Automatic recognition of facial expressions can be an important component of natural human-machine interactions. While a lot of samples are desirable for estimating more accurately the feelings of a person (e.g. likeness) about a machine interface, in real world situation, only a small number of samples must be obtained because the high cost in collecting emotions from observed person. This paper proposes a system that solves this problem conforming to individual differences. A new method is developed for facial expression classification based on the combination of Holographic Neural Networks (HNN) and Type-2 Fuzzy Logic. For the recognition of emotions induced by facial expressions, compared with former HNN and Support Vector Machines (SVM) classifiers, proposed method achieved the best generalization performance using less learning time than SVM classifiers.

  6. Conformational heterogeneity of the calmodulin binding interface

    Science.gov (United States)

    Shukla, Diwakar; Peck, Ariana; Pande, Vijay S.

    2016-04-01

    Calmodulin (CaM) is a ubiquitous Ca2+ sensor and a crucial signalling hub in many pathways aberrantly activated in disease. However, the mechanistic basis of its ability to bind diverse signalling molecules including G-protein-coupled receptors, ion channels and kinases remains poorly understood. Here we harness the high resolution of molecular dynamics simulations and the analytical power of Markov state models to dissect the molecular underpinnings of CaM binding diversity. Our computational model indicates that in the absence of Ca2+, sub-states in the folded ensemble of CaM's C-terminal domain present chemically and sterically distinct topologies that may facilitate conformational selection. Furthermore, we find that local unfolding is off-pathway for the exchange process relevant for peptide binding, in contrast to prior hypotheses that unfolding might account for binding diversity. Finally, our model predicts a novel binding interface that is well-populated in the Ca2+-bound regime and, thus, a candidate for pharmacological intervention.

  7. Automatic segmentation of bladder in CT images

    Institute of Scientific and Technical Information of China (English)

    Feng SHI; Jie YANG; Yue-min ZHU

    2009-01-01

    Segmentation of the bladder in computerized tomography (CT) images is an important step in radiation therapy planning of prostate cancer. We present a new segmentation scheme to automatically delineate the bladder contour in CT images with three major steps. First, we use the mean shift algorithm to obtain a clustered image containing the rough contour of the bladder, which is then extracted in the second step by applying a region-growing algorithm with the initial seed point selected from a line-by-line scanning process. The third step is to refine the bladder contour more accurately using the rolling-ball algorithm. These steps are then extended to segment the bladder volume in a slice-by-slice manner. The obtained results were compared to manual segmentation by radiation oncologists. The average values of sensitivity, specificity, positive predictive value, negative predictive value, and Hausdorff distance are 86.5%, 96.3%, 90.5%, 96.5%, and 2.8 pixels, respectively. The results show that the bladder can be accurately segmented.

  8. Controlled versus automatic processes: which is dominant to safety? The moderating effect of inhibitory control.

    Science.gov (United States)

    Xu, Yaoshan; Li, Yongjuan; Ding, Weidong; Lu, Fan

    2014-01-01

    This study explores the precursors of employees' safety behaviors based on a dual-process model, which suggests that human behaviors are determined by both controlled and automatic cognitive processes. Employees' responses to a self-reported survey on safety attitudes capture their controlled cognitive process, while the automatic association concerning safety measured by an Implicit Association Test (IAT) reflects employees' automatic cognitive processes about safety. In addition, this study investigates the moderating effects of inhibition on the relationship between self-reported safety attitude and safety behavior, and that between automatic associations towards safety and safety behavior. The results suggest significant main effects of self-reported safety attitude and automatic association on safety behaviors. Further, the interaction between self-reported safety attitude and inhibition and that between automatic association and inhibition each predict unique variances in safety behavior. Specifically, the safety behaviors of employees with lower level of inhibitory control are influenced more by automatic association, whereas those of employees with higher level of inhibitory control are guided more by self-reported safety attitudes. These results suggest that safety behavior is the joint outcome of both controlled and automatic cognitive processes, and the relative importance of these cognitive processes depends on employees' individual differences in inhibitory control. The implications of these findings for theoretical and practical issues are discussed at the end.

  9. Controlled versus automatic processes: which is dominant to safety? The moderating effect of inhibitory control.

    Directory of Open Access Journals (Sweden)

    Yaoshan Xu

    Full Text Available This study explores the precursors of employees' safety behaviors based on a dual-process model, which suggests that human behaviors are determined by both controlled and automatic cognitive processes. Employees' responses to a self-reported survey on safety attitudes capture their controlled cognitive process, while the automatic association concerning safety measured by an Implicit Association Test (IAT reflects employees' automatic cognitive processes about safety. In addition, this study investigates the moderating effects of inhibition on the relationship between self-reported safety attitude and safety behavior, and that between automatic associations towards safety and safety behavior. The results suggest significant main effects of self-reported safety attitude and automatic association on safety behaviors. Further, the interaction between self-reported safety attitude and inhibition and that between automatic association and inhibition each predict unique variances in safety behavior. Specifically, the safety behaviors of employees with lower level of inhibitory control are influenced more by automatic association, whereas those of employees with higher level of inhibitory control are guided more by self-reported safety attitudes. These results suggest that safety behavior is the joint outcome of both controlled and automatic cognitive processes, and the relative importance of these cognitive processes depends on employees' individual differences in inhibitory control. The implications of these findings for theoretical and practical issues are discussed at the end.

  10. Regular conformal system for Einstein equations

    Energy Technology Data Exchange (ETDEWEB)

    Choquet-Bruhat, Y.; Novello, M.

    1987-06-21

    We give a system of partial differential equations satisfied by a metric g conformal to an Einstein metric and by the conformal factor ..omega.., regular system in the sense that it does not contain negative powers of ..omega... We use the ideas of Friedrich but we obtain here a hyperbolic system in the sense of Leray, by a different method.

  11. Fusion rules in conformal field theory

    International Nuclear Information System (INIS)

    Several aspects of fusion rings and fusion rule algebras, and of their manifestations in two-dimensional (conformal) field theory, are described: diagonalization and the connection with modular invariance; the presentation in terms of quotients of polynomial rings; fusion graphs; various strategies that allow for a partial classification; and the role of the fusion rules in the conformal bootstrap programme. (orig.)

  12. The conformal spin and statistics theorem

    CERN Document Server

    Guido, D; Guido, Daniele; Longo, Roberto

    1995-01-01

    We prove the equality between the statistics phase and the conformal univalence for a superselection sector with finite index in Conformal Quantum Field Theory on S^1. A relevant point is the description of the PCT symmetry and the construction of the global conjugate charge.

  13. DIMENSIONS FOR RANDOM SELF-CONFORMAL SETS

    Institute of Scientific and Technical Information of China (English)

    Liu Yanyan; Wu Jun

    2003-01-01

    A set is called regular if its Hausdorff dimension and upper box-counting dimension coincide.In this paper,we prove that the random self-conformal set is regular almost surely.Also we determine the dimensions for a class of random self-conformal sets.

  14. 40 CFR 52.938 - General conformity.

    Science.gov (United States)

    2010-07-01

    ... Implementation Plan (SIP). The Commonwealth of Kentucky incorporated by reference regulations 40 CFR part 51... 40 Protection of Environment 3 2010-07-01 2010-07-01 false General conformity. 52.938 Section 52...) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS Kentucky § 52.938 General conformity. The...

  15. Testing Library Specifications by Verifying Conformance Tests

    DEFF Research Database (Denmark)

    Kiniry, Joseph Roland; Zimmerman, Daniel; Hyland, Ralph

    2012-01-01

    conformance test suites. Rather than executing the conformance tests, FCTD uses them to measure the correctness and utility of specifications through static verification. FCTD is beginning to see significant use within the JML community and is the cornerstone process of the JML Spec-a-thons, meetings...

  16. 14 CFR 17.45 - Conforming amendments.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Conforming amendments. 17.45 Section 17.45 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PROCEDURAL RULES PROCEDURES FOR PROTESTS AND CONTRACTS DISPUTES Finality and Review § 17.45 Conforming amendments. The...

  17. An extension theorem for conformal gauge singularities

    CERN Document Server

    Tod, Paul

    2007-01-01

    We analyse conformal gauge, or isotropic, singularities in cosmological models in general relativity. Using the calculus of tractors, we find conditions in terms of tractor curvature for a local extension of the conformal structure through a cosmological singularity and prove a local extension theorem.

  18. Universal hydrodynamics of non-conformal branes

    NARCIS (Netherlands)

    I. Kanitscheider; K. Skenderis

    2009-01-01

    We examine the hydrodynamic limit of non-conformal branes using the recently developed precise holographic dictionary. We first streamline the discussion of holography for backgrounds that asymptote locally to non-conformal brane solutions by showing that all such solutions can be obtained from high

  19. Conformal non-relativistic hydrodynamics from gravity.

    OpenAIRE

    Rangamani, Mukund; Ross, Simon F.; Son, D.T.; Thompson, Ethan G.

    2009-01-01

    We show that the recently constructed holographic duals of conformal non-relativistic theories behave hydrodynamically at long distances, and construct the gravitational dual of fluid flows in a long-wavelength approximation. We compute the thermal conductivity of the holographic conformal non-relativistic fluid. The corresponding Prandtl number is equal to one.

  20. Conformity to Peer Pressure in Preschool Children

    Science.gov (United States)

    Haun, Daniel B. M.; Tomasello, Michael

    2011-01-01

    Both adults and adolescents often conform their behavior and opinions to peer groups, even when they themselves know better. The current study investigated this phenomenon in 24 groups of 4 children between 4;2 and 4;9 years of age. Children often made their judgments conform to those of 3 peers, who had made obviously erroneous but unanimous…

  1. Improved Modeling of Open Waveguide Aperture Radiators for use in Conformal Antenna Arrays

    Science.gov (United States)

    Nelson, Gregory James

    Open waveguide apertures have been used as radiating elements in conformal arrays. Individual radiating element model patterns are used in constructing overall array models. The existing models for these aperture radiating elements may not accurately predict the array pattern for TEM waves which are not on boresight for each radiating element. In particular, surrounding structures can affect the far field patterns of these apertures, which ultimately affects the overall array pattern. New models of open waveguide apertures are developed here with the goal of accounting for the surrounding structure effects on the aperture far field patterns such that the new models make accurate pattern predictions. These aperture patterns (both E plane and H plane) are measured in an anechoic chamber and the manner in which they deviate from existing model patterns are studied. Using these measurements as a basis, existing models for both E and H planes are updated with new factors and terms which allow the prediction of far field open waveguide aperture patterns with improved accuracy. These new and improved individual radiator models are then used to predict overall conformal array patterns. Arrays of open waveguide apertures are constructed and measured in a similar fashion to the individual aperture measurements. These measured array patterns are compared with the newly modeled array patterns to verify the improved accuracy of the new models as compared with the performance of existing models in making array far field pattern predictions. The array pattern lobe characteristics are then studied for predicting fully circularly conformal arrays of varying radii. The lobe metrics that are tracked are angular location and magnitude as the radii of the conformal arrays are varied. A constructed, measured array that is close to conforming to a circular surface is compared with a fully circularly conformal modeled array pattern prediction, with the predicted lobe angular locations and

  2. A geodesic model in conformal superspace

    CERN Document Server

    Gomes, Henrique de A

    2016-01-01

    In this paper, I look for the most general geometrodynamical symmetries compatible with spatial relational principles. I argue that they lead either to a completely static Universe, or one embodying spatial conformal diffeomorphisms. Demanding locality for an action compatible with these principles severely limits its form, both for the gravitational part as well as all matter couplings. The simplest and most natural choice for pure gravity has two propagating physical degrees of freedom (and no refoliation-invariance). The system has a geometric interpretation as a geodesic model in infinite dimensional conformal superspace. Conformal superspace is a stratified manifold, with different strata corresponding to different isometry groups. Choosing space to be (homeomorphic to) $S^3$, conformal superspace has a preferred stratum with maximal stabilizer group. This stratum consists of a single point -- corresponding to the conformal geometry of the round 3-sphere. This is the most homogeneous non-degenerate geome...

  3. Finite Conformal Quantum Gravity and Nonsingular Spacetimes

    CERN Document Server

    Modesto, Leonardo

    2016-01-01

    We explicitly prove that a class of finite quantum gravitational theories (in odd as well as in even dimension) is actually a range of anomaly-free conformally invariant theories in the spontaneously broken phase of the conformal Weyl symmetry. At classical level we show how the Weyl conformal invariance is likely able to tame the spacetime singularities that plague not only Einstein gravity, but also local and weakly non-local higher derivative theories. This latter statement is rigorously proved by a singularity theorem that applies to a large class of weakly non-local theories. Following the seminal paper by Narlikar and Kembhavi, we provide an explicit construction of singularity-free black hole exact solutions conformally equivalent to the Schwarzschild metric. Furthermore, we show that the FRW cosmological solutions and the Belinski, Khalatnikov, Lifshitz (BKL) spacetimes, which exactly solve the classical equations of motion, are conformally equivalent to regular spacetimes. Finally, we prove that the ...

  4. Conformal correlators of mixed-symmetry tensors

    CERN Document Server

    Costa, Miguel S

    2015-01-01

    We generalize the embedding formalism for conformal field theories to the case of general operators with mixed symmetry. The index-free notation encoding symmetric tensors as polynomials in an auxiliary polarization vector is extended to mixed-symmetry tensors by introducing a new commuting or anticommuting polarization vector for each row or column in the Young diagram that describes the index symmetries of the tensor. We determine the tensor structures that are allowed in n-point conformal correlation functions and give an algorithm for counting them in terms of tensor product coefficients. We show, with an example, how the new formalism can be used to compute conformal blocks of arbitrary external fields for the exchange of any conformal primary and its descendants. The matching between the number of tensor structures in conformal field theory correlators of operators in d dimensions and massive scattering amplitudes in d+1 dimensions is also seen to carry over to mixed-symmetry tensors.

  5. Conformant Planning via Symbolic Model Checking

    CERN Document Server

    Cimatti, A; 10.1613/jair.774

    2011-01-01

    We tackle the problem of planning in nondeterministic domains, by presenting a new approach to conformant planning. Conformant planning is the problem of finding a sequence of actions that is guaranteed to achieve the goal despite the nondeterminism of the domain. Our approach is based on the representation of the planning domain as a finite state automaton. We use Symbolic Model Checking techniques, in particular Binary Decision Diagrams, to compactly represent and efficiently search the automaton. In this paper we make the following contributions. First, we present a general planning algorithm for conformant planning, which applies to fully nondeterministic domains, with uncertainty in the initial condition and in action effects. The algorithm is based on a breadth-first, backward search, and returns conformant plans of minimal length, if a solution to the planning problem exists, otherwise it terminates concluding that the problem admits no conformant solution. Second, we provide a symbolic representation ...

  6. Unification of automatic target tracking and automatic target recognition

    Science.gov (United States)

    Schachter, Bruce J.

    2014-06-01

    The subject being addressed is how an automatic target tracker (ATT) and an automatic target recognizer (ATR) can be fused together so tightly and so well that their distinctiveness becomes lost in the merger. This has historically not been the case outside of biology and a few academic papers. The biological model of ATT∪ATR arises from dynamic patterns of activity distributed across many neural circuits and structures (including retina). The information that the brain receives from the eyes is "old news" at the time that it receives it. The eyes and brain forecast a tracked object's future position, rather than relying on received retinal position. Anticipation of the next moment - building up a consistent perception - is accomplished under difficult conditions: motion (eyes, head, body, scene background, target) and processing limitations (neural noise, delays, eye jitter, distractions). Not only does the human vision system surmount these problems, but it has innate mechanisms to exploit motion in support of target detection and classification. Biological vision doesn't normally operate on snapshots. Feature extraction, detection and recognition are spatiotemporal. When vision is viewed as a spatiotemporal process, target detection, recognition, tracking, event detection and activity recognition, do not seem as distinct as they are in current ATT and ATR designs. They appear as similar mechanism taking place at varying time scales. A framework is provided for unifying ATT and ATR.

  7. Annual review in automatic programming

    CERN Document Server

    Goodman, Richard

    2014-01-01

    Annual Review in Automatic Programming, Volume 2 is a collection of papers that discusses the controversy about the suitability of COBOL as a common business oriented language, and the development of different common languages for scientific computation. A couple of papers describes the use of the Genie system in numerical calculation and analyzes Mercury autocode in terms of a phrase structure language, such as in the source language, target language, the order structure of ATLAS, and the meta-syntactical language of the assembly program. Other papers explain interference or an ""intermediate

  8. Unsupervised automatic music genre classification

    OpenAIRE

    Barreira, Luís Filipe Marques

    2010-01-01

    Trabalho apresentado no âmbito do Mestrado em Engenharia Informática, como requisito parcial para obtenção do grau de Mestre em Engenharia Informática In this study we explore automatic music genre recognition and classification of digital music. Music has always been a reflection of culture di erences and an influence in our society. Today’s digital content development triggered the massive use of digital music. Nowadays,digital music is manually labeled without following a universa...

  9. Annual review in automatic programming

    CERN Document Server

    Goodman, Richard

    2014-01-01

    Annual Review in Automatic Programming, Volume 4 is a collection of papers that deals with the GIER ALGOL compiler, a parameterized compiler based on mechanical linguistics, and the JOVIAL language. A couple of papers describes a commercial use of stacks, an IBM system, and what an ideal computer program support system should be. One paper reviews the system of compilation, the development of a more advanced language, programming techniques, machine independence, and program transfer to other machines. Another paper describes the ALGOL 60 system for the GIER machine including running ALGOL pro

  10. The Automaticity of Social Life.

    Science.gov (United States)

    Bargh, John A; Williams, Erin L

    2006-02-01

    Much of social life is experienced through mental processes that are not intended and about which one is fairly oblivious. These processes are automatically triggered by features of the immediate social environment, such as the group memberships of other people, the qualities of their behavior, and features of social situations (e.g., norms, one's relative power). Recent research has shown these nonconscious influences to extend beyond the perception and interpretation of the social world to the actual guidance, over extended time periods, of one's important goal pursuits and social interactions.

  11. Automatic analysis of multiparty meetings

    Indian Academy of Sciences (India)

    Steve Renals

    2011-10-01

    This paper is about the recognition and interpretation of multiparty meetings captured as audio, video and other signals. This is a challenging task since the meetings consist of spontaneous and conversational interactions between a number of participants: it is a multimodal, multiparty, multistream problem. We discuss the capture and annotation of the Augmented Multiparty Interaction (AMI) meeting corpus, the development of a meeting speech recognition system, and systems for the automatic segmentation, summarization and social processing of meetings, together with some example applications based on these systems.

  12. Automatic Inference of DATR Theories

    CERN Document Server

    Barg, P

    1996-01-01

    This paper presents an approach for the automatic acquisition of linguistic knowledge from unstructured data. The acquired knowledge is represented in the lexical knowledge representation language DATR. A set of transformation rules that establish inheritance relationships and a default-inference algorithm make up the basis components of the system. Since the overall approach is not restricted to a special domain, the heuristic inference strategy uses criteria to evaluate the quality of a DATR theory, where different domains may require different criteria. The system is applied to the linguistic learning task of German noun inflection.

  13. The Automaticity of Social Life.

    Science.gov (United States)

    Bargh, John A; Williams, Erin L

    2006-02-01

    Much of social life is experienced through mental processes that are not intended and about which one is fairly oblivious. These processes are automatically triggered by features of the immediate social environment, such as the group memberships of other people, the qualities of their behavior, and features of social situations (e.g., norms, one's relative power). Recent research has shown these nonconscious influences to extend beyond the perception and interpretation of the social world to the actual guidance, over extended time periods, of one's important goal pursuits and social interactions. PMID:18568084

  14. Automatic Generation of Technical Documentation

    CERN Document Server

    Reiter, E R; Levine, J; Reiter, Ehud; Mellish, Chris; Levine, John

    1994-01-01

    Natural-language generation (NLG) techniques can be used to automatically produce technical documentation from a domain knowledge base and linguistic and contextual models. We discuss this application of NLG technology from both a technical and a usefulness (costs and benefits) perspective. This discussion is based largely on our experiences with the IDAS documentation-generation project, and the reactions various interested people from industry have had to IDAS. We hope that this summary of our experiences with IDAS and the lessons we have learned from it will be beneficial for other researchers who wish to build technical-documentation generation systems.

  15. Coordinated hybrid automatic repeat request

    KAUST Repository

    Makki, Behrooz

    2014-11-01

    We develop a coordinated hybrid automatic repeat request (HARQ) approach. With the proposed scheme, if a user message is correctly decoded in the first HARQ rounds, its spectrum is allocated to other users, to improve the network outage probability and the users\\' fairness. The results, which are obtained for single- and multiple-antenna setups, demonstrate the efficiency of the proposed approach in different conditions. For instance, with a maximum of M retransmissions and single transmit/receive antennas, the diversity gain of a user increases from M to (J+1)(M-1)+1 where J is the number of users helping that user.

  16. Automatic transcription of polyphonic singing

    OpenAIRE

    Paščinski, Uroš

    2015-01-01

    In this work we focus on automatic transcription of polyphonic singing. In particular we do the multiple fundamental frequency (F0) estimation. From the terrain recordings a test set of Slovenian folk songs with polyphonic singing is extracted and manually transcribed. On the test set we try the general algorithm for multiple F0 detection. An interactive visualization of the main parts of the algorithm is made to analyse how it works and try to detect possible issues. As the data set is ne...

  17. Conforming Morse-Smale Complexes.

    Science.gov (United States)

    Gyulassy, Attila; Günther, David; Levine, Joshua A; Tierny, Julien; Pascucci, Valerio

    2014-12-01

    Morse-Smale (MS) complexes have been gaining popularity as a tool for feature-driven data analysis and visualization. However, the quality of their geometric embedding and the sole dependence on the input scalar field data can limit their applicability when expressing application-dependent features. In this paper we introduce a new combinatorial technique to compute an MS complex that conforms to both an input scalar field and an additional, prior segmentation of the domain. The segmentation constrains the MS complex computation guaranteeing that boundaries in the segmentation are captured as separatrices of the MS complex. We demonstrate the utility and versatility of our approach with two applications. First, we use streamline integration to determine numerically computed basins/mountains and use the resulting segmentation as an input to our algorithm. This strategy enables the incorporation of prior flow path knowledge, effectively resulting in an MS complex that is as geometrically accurate as the employed numerical integration. Our second use case is motivated by the observation that often the data itself does not explicitly contain features known to be present by a domain expert. We introduce edit operations for MS complexes so that a user can directly modify their features while maintaining all the advantages of a robust topology-based representation.

  18. 47 CFR 2.1072 - Limitation on Declaration of Conformity.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false Limitation on Declaration of Conformity. 2.1072... Conformity § 2.1072 Limitation on Declaration of Conformity. (a) The Declaration of Conformity signifies that...'s rules. (b) A Declaration of Conformity by the responsible party is effective until a...

  19. Automatic gender detection of dream reports: A promising approach.

    Science.gov (United States)

    Wong, Christina; Amini, Reza; De Koninck, Joseph

    2016-08-01

    A computer program was developed in an attempt to differentiate the dreams of males from females. Hypothesized gender predictors were based on previous literature concerning both dream content and written language features. Dream reports from home-collected dream diaries of 100 male (144 dreams) and 100 female (144 dreams) adolescent Anglophones were matched for equal length. They were first scored with the Hall and Van de Castle (HVDC) scales and quantified using DreamSAT. Two male and two female undergraduate students were asked to read all dreams and predict the dreamer's gender. They averaged a pairwise percent correct gender prediction of 75.8% (κ=0.516), while the Automatic Analysis showed that the computer program's accuracy was 74.5% (κ=0.492), both of which were higher than chance of 50% (κ=0.00). The prediction levels were maintained when dreams containing obvious gender identifiers were eliminated and integration of HVDC scales did not improve prediction.

  20. Detection and Prediction of Epileptic Seizures

    DEFF Research Database (Denmark)

    Duun-Henriksen, Jonas

    monitoring of their brain waves. More specifically, three issues were investigated: The feasibility of automatic seizure prediction, optimization of automatic seizure detection algorithms, and the link between intra- and extracranial EEG. Regarding feasibility of automatic seizure prediction, neither...... seizure prediction algorithms. More promising results were obtained in the investigating of possible use of an outpatient EEG monitoring device for idiopathic generalized epilepsy patients. Combined with an automatic seizure detection algorithm such a device can give an objective account of the paroxysm...... detected without any false positive detections. This was obtained using a generic algorithm on the signals from only a single frontal channel. Applying the same algorithm architecture on EEG data from two outpatient children monitored for approximately three entire days each, the sensitivity was 90...

  1. Representation of target-bound drugs by computed conformers: implications for conformational libraries

    Directory of Open Access Journals (Sweden)

    Goede Andrean

    2006-06-01

    Full Text Available Abstract Background The increasing number of known protein structures provides valuable information about pharmaceutical targets. Drug binding sites are identifiable and suitable lead compounds can be proposed. The flexibility of ligands is a critical point for the selection of potential drugs. Since computed 3D structures of millions of compounds are available, the knowledge of their binding conformations would be a great benefit for the development of efficient screening methods. Results Integration of two public databases allowed superposition of conformers for 193 approved drugs with 5507 crystallised target-bound counterparts. The generation of 9600 drug conformers using an atomic force field was carried out to obtain an optimal coverage of the conformational space. Bioactive conformations are best described by a conformational ensemble: half of all drugs exhibit multiple active states, distributed over the entire range of the reachable energy and conformational space. A number of up to 100 conformers per drug enabled us to reproduce the bound states within a similarity threshold of 1.0 Å in 70% of all cases. This fraction rises to about 90% for smaller or average sized drugs. Conclusion Single drugs adopt multiple bioactive conformations if they interact with different target proteins. Due to the structural diversity of binding sites they adopt conformations that are distributed over a broad conformational space and wide energy range. Since the majority of drugs is well represented by a predefined low number of conformers (up to 100 this procedure is a valuable method to compare compounds by three-dimensional features or for fast similarity searches starting with pharmacophores. The underlying 9600 generated drug conformers are downloadable from the Super Drug Web site 1. All superpositions are visualised at the same source. Additional conformers (110,000 of 2400 classified WHO-drugs are also available.

  2. Automatic generation of tourist brochures

    KAUST Repository

    Birsak, Michael

    2014-05-01

    We present a novel framework for the automatic generation of tourist brochures that include routing instructions and additional information presented in the form of so-called detail lenses. The first contribution of this paper is the automatic creation of layouts for the brochures. Our approach is based on the minimization of an energy function that combines multiple goals: positioning of the lenses as close as possible to the corresponding region shown in an overview map, keeping the number of lenses low, and an efficient numbering of the lenses. The second contribution is a route-aware simplification of the graph of streets used for traveling between the points of interest (POIs). This is done by reducing the graph consisting of all shortest paths through the minimization of an energy function. The output is a subset of street segments that enable traveling between all the POIs without considerable detours, while at the same time guaranteeing a clutter-free visualization. © 2014 The Author(s) Computer Graphics Forum © 2014 The Eurographics Association and John Wiley & Sons Ltd. Published by John Wiley & Sons Ltd.

  3. Early prediction of lung cancer recurrence after stereotactic radiotherapy using second order texture statistics

    Science.gov (United States)

    Mattonen, Sarah A.; Palma, David A.; Haasbeek, Cornelis J. A.; Senan, Suresh; Ward, Aaron D.

    2014-03-01

    Benign radiation-induced lung injury is a common finding following stereotactic ablative radiotherapy (SABR) for lung cancer, and is often difficult to differentiate from a recurring tumour due to the ablative doses and highly conformal treatment with SABR. Current approaches to treatment response assessment have shown limited ability to predict recurrence within 6 months of treatment. The purpose of our study was to evaluate the accuracy of second order texture statistics for prediction of eventual recurrence based on computed tomography (CT) images acquired within 6 months of treatment, and compare with the performance of first order appearance and lesion size measures. Consolidative and ground-glass opacity (GGO) regions were manually delineated on post-SABR CT images. Automatic consolidation expansion was also investigated to act as a surrogate for GGO position. The top features for prediction of recurrence were all texture features within the GGO and included energy, entropy, correlation, inertia, and first order texture (standard deviation of density). These predicted recurrence with 2-fold cross validation (CV) accuracies of 70-77% at 2- 5 months post-SABR, with energy, entropy, and first order texture having leave-one-out CV accuracies greater than 80%. Our results also suggest that automatic expansion of the consolidation region could eliminate the need for manual delineation, and produced reproducible results when compared to manually delineated GGO. If validated on a larger data set, this could lead to a clinically useful computer-aided diagnosis system for prediction of recurrence within 6 months of SABR and allow for early salvage therapy for patients with recurrence.

  4. Statistically significant dependence of the Xaa-Pro peptide bond conformation on secondary structure and amino acid sequence

    Directory of Open Access Journals (Sweden)

    Leitner Dietmar

    2005-04-01

    Full Text Available Abstract Background A reliable prediction of the Xaa-Pro peptide bond conformation would be a useful tool for many protein structure calculation methods. We have analyzed the Protein Data Bank and show that the combined use of sequential and structural information has a predictive value for the assessment of the cis versus trans peptide bond conformation of Xaa-Pro within proteins. For the analysis of the data sets different statistical methods such as the calculation of the Chou-Fasman parameters and occurrence matrices were used. Furthermore we analyzed the relationship between the relative solvent accessibility and the relative occurrence of prolines in the cis and in the trans conformation. Results One of the main results of the statistical investigations is the ranking of the secondary structure and sequence information with respect to the prediction of the Xaa-Pro peptide bond conformation. We observed a significant impact of secondary structure information on the occurrence of the Xaa-Pro peptide bond conformation, while the sequence information of amino acids neighboring proline is of little predictive value for the conformation of this bond. Conclusion In this work, we present an extensive analysis of the occurrence of the cis and trans proline conformation in proteins. Based on the data set, we derived patterns and rules for a possible prediction of the proline conformation. Upon adoption of the Chou-Fasman parameters, we are able to derive statistically relevant correlations between the secondary structure of amino acid fragments and the Xaa-Pro peptide bond conformation.

  5. Automatic acquisition of motion trajectories: tracking hockey players

    Science.gov (United States)

    Okuma, Kenji; Little, James J.; Lowe, David

    2003-12-01

    Computer systems that have the capability of analyzing complex and dynamic scenes play an essential role in video annotation. Scenes can be complex in such a way that there are many cluttered objects with different colors, shapes and sizes, and can be dynamic with multiple interacting moving objects and a constantly changing background. In reality, there are many scenes that are complex, dynamic, and challenging enough for computers to describe. These scenes include games of sports, air traffic, car traffic, street intersections, and cloud transformations. Our research is about the challenge of inventing a descriptive computer system that analyzes scenes of hockey games where multiple moving players interact with each other on a constantly moving background due to camera motions. Ultimately, such a computer system should be able to acquire reliable data by extracting the players" motion as their trajectories, querying them by analyzing the descriptive information of data, and predict the motions of some hockey players based on the result of the query. Among these three major aspects of the system, we primarily focus on visual information of the scenes, that is, how to automatically acquire motion trajectories of hockey players from video. More accurately, we automatically analyze the hockey scenes by estimating parameters (i.e., pan, tilt, and zoom) of the broadcast cameras, tracking hockey players in those scenes, and constructing a visual description of the data by displaying trajectories of those players. Many technical problems in vision such as fast and unpredictable players' motions and rapid camera motions make our challenge worth tackling. To the best of our knowledge, there have not been any automatic video annotation systems for hockey developed in the past. Although there are many obstacles to overcome, our efforts and accomplishments would hopefully establish the infrastructure of the automatic hockey annotation system and become a milestone for

  6. Beyond Halo Mass: Galactic Conformity as a Smoking Gun of Central Galaxy Assembly Bias

    CERN Document Server

    Hearin, Andrew P; Bosch, Frank C van den

    2014-01-01

    Quenched central galaxies tend to reside in a preferentially quenched large-scale environment, a phenomenon that has been dubbed galactic conformity. Remarkably, this tendency persists out to scales far larger than the virial radius of the halo hosting the central. Therefore, conformity manifestly violates the widely adopted assumption that the dark matter halo mass Mvir exclusively governs galaxy occupation statistics. This paper is the first in a series studying the implications of the observed conformity signal for the galaxy-dark matter connection. We show that recent measurements of conformity on scales R ~1-5 Mpc imply that central galaxy quenching statistics cannot be correctly predicted with the knowledge of Mvir alone. We also demonstrate that ejected (or `backsplash') satellites cannot give rise to the signal. We then invoke the age matching model, which is predicated on the co-evolution of galaxies and halos. We find that this model produces a strong signal, and that central galaxies are solely res...

  7. Sensitivity of Bragg gratings in birefringent optical fiber to transverse compression between conforming materials.

    Science.gov (United States)

    Dennison, Christopher R; Wild, Peter M

    2010-04-20

    A theoretical and experimental investigation of the transverse load sensitivity of Bragg gratings in birefringent fibers to conforming contact is presented. A plane elasticity model is used to predict the contact dimensions between a conforming material and optical fiber and the principal stresses, indicating birefringence, created as a result of this contact. The transverse load sensitivity of commercially available birefringent fiber is experimentally measured for two cases of conforming contact. Theoretical and experimental results show that birefringent optical fiber can be used to make modulus-independent measurements of contact load. Therefore, Bragg gratings could be applied to conforming contact load measurements while avoiding some of the complications associated with existing contact sensors: specifically, the necessity to precalibrate by using materials with mechanical properties identical to those found in situ.

  8. Vibrational spectra, DFT calculations, conformational stabilities and assignments of the fundamentals of the 1-butylpiperazine

    Science.gov (United States)

    Bağlayan, Özge; Kaya, Mehmet Fatih; Güneş, Esma; Şenyel, Mustafa

    2016-10-01

    FT-IR and FT-Raman spectra of 1-butylpiperazine (1bpa) were experimentally recorded in the region of 4000-10 cm-1 and 4000-100 cm-1, respectively. The optimized geometric parameters, conformational equilibria, normal mode frequencies and corresponding vibrational assignments of 1bpa (C8H18N2) are theoretically examined by means of B3LYP hybrid density functional theory (DFT) method together with 6-31++G(d,p) basis set. Also, reliable conformational investigation and vibrational assignments have been performed by the potential energy surface (PES) and potential energy distribution (PED) analysis, respectively. Calculations are made for four possible conformations. According to the experimental and theoretical data, density functional B3LYP method provides reliable results for predicting vibrational wavenumbers and equatorial-equatorial conformer is considered to be the most stable form of 1bpa.

  9. Automatic Speech Segmentation Based on HMM

    OpenAIRE

    M. Kroul

    2007-01-01

    This contribution deals with the problem of automatic phoneme segmentation using HMMs. Automatization of speech segmentation task is important for applications, where large amount of data is needed to process, so manual segmentation is out of the question. In this paper we focus on automatic segmentation of recordings, which will be used for triphone synthesis unit database creation. For speech synthesis, the speech unit quality is a crucial aspect, so the maximal accuracy in segmentation is ...

  10. Towards unifying inheritance and automatic program specialization

    DEFF Research Database (Denmark)

    Schultz, Ulrik Pagh

    2002-01-01

    Inheritance allows a class to be specialized and its attributes refined, but implementation specialization can only take place by overriding with manually implemented methods. Automatic program specialization can generate a specialized, effcient implementation. However, specialization of programs...... with covariant specialization to control the automatic application of program specialization to class members. Lapis integrates object-oriented concepts, block structure, and techniques from automatic program specialization to provide both a language where object-oriented designs can be e#ciently implemented...

  11. Automatic Control of Water Pumping Stations

    Institute of Scientific and Technical Information of China (English)

    Muhannad Alrheeh; JIANG Zhengfeng

    2006-01-01

    Automatic Control of pumps is an interesting proposal to operate water pumping stations among many kinds of water pumping stations according to their functions.In this paper, our pumping station is being used for water supply system. This paper is to introduce the idea of pump controller and the important factors that must be considering when we want to design automatic control system of water pumping stations. Then the automatic control circuit with the function of all components will be introduced.

  12. An automatic visual analysis system for tennis

    OpenAIRE

    Connaghan, Damien; Moran, Kieran; O''Connor, Noel E.

    2013-01-01

    This article presents a novel video analysis system for coaching tennis players of all levels, which uses computer vision algorithms to automatically edit and index tennis videos into meaningful annotations. Existing tennis coaching software lacks the ability to automatically index a tennis match into key events, and therefore, a coach who uses existing software is burdened with time-consuming manual video editing. This work aims to explore the effectiveness of a system to automatically de...

  13. Spectra of conformal sigma models

    Energy Technology Data Exchange (ETDEWEB)

    Tlapak, Vaclav

    2015-04-15

    In this thesis the spectra of conformal sigma models defined on (generalized) symmetric spaces are analysed. The spaces where sigma models are conformal without the addition of a Wess-Zumino term are supermanifolds, in other words spaces that include fermionic directions. After a brief review of the general construction of vertex operators and the background field expansion, we compute the diagonal terms of the one-loop anomalous dimensions of sigma models on semi-symmetric spaces. We find that the results are formally identical to the symmetric case. However, unlike for sigma models on symmetric spaces, off diagonal terms that lead to operator mixing are also present. These are not computed here. We then present a detailed analysis of the one-loop spectrum of the supersphere S{sup 3} {sup vertical} {sup stroke} {sup 2} sigma model as one of the simplest examples. The analysis illustrates the power and simplicity of the construction. We use this data to revisit a duality with the OSP(4 vertical stroke 2) Gross-Neveu model that was proposed by Candu and Saleur. With the help of a recent all-loop result for the anomalous dimension of (1)/(2)BPS operators of Gross-Neveu models, we are able to recover the entire zero-mode spectrum of the supersphere model. We also argue that the sigma model constraints and its equations of motion are implemented correctly in the Gross-Neveu model, including the one-loop data. The duality is further supported by a new all-loop result for the anomalous dimension of the ground states of the sigma model. However, higher-gradient operators cannot be completely recovered. It is possible that this discrepancy is related to a known instability of the sigma model. The instability of sigma models is due to symmetry preserving high-gradient operators that become relevant at arbitrarily small values of the coupling. This feature has been observed long ago in one-loop calculations of the O(N)-vector model and soon been realized to be a generic

  14. Integral Equation Theory for the Conformation of Polyelectrolytes

    Science.gov (United States)

    Shew, C.-Y.; Yethiraj, A.

    1996-03-01

    The equilibrium conformation properties of polyelectrolyes are explored using the integral equation theory. The polymer molecules are modeled as freely-jointed beads that interact via a hard sphere plus screened Coulomb potential. To obtain the intramolecuar correlation function ( and hence the chain conformations) the many chain system is replaced by a single chain whose beads interact via the bare interaction plus a solvent-induced potential, which approximately accounts for the presence of the other molecules. Since this solvent induced potential is a functional of the intramolecular correlations it is obtained iteratively in a self-consistent fashion. The intramolecular correlation functions for a given solvation potential are obtained via Monte Carlo simulation of a single chain. A thread model of the polymer molecules is also investigated, in which case the single chain conformations are obtained using a variational method. The predictions of the theory for these two models are similar. For single chains ~ N^2 ( is the mean square end-to-end distance and N is the degree of polymerization) in salt free solutions, and ~ N^1.2 in high salt solutions. At high polymer concentration ~ N. The theory provides a means of interpolating between these limiting cases. An interesting feature is that there is a very sharp drop in polymer size at very low concentrations which happens because the overlap threshold concentration in polyelectrolytes solutions is very small.

  15. Thermal adaptation of conformational dynamics in ribonuclease H.

    Directory of Open Access Journals (Sweden)

    Kate A Stafford

    Full Text Available The relationship between inherent internal conformational processes and enzymatic activity or thermodynamic stability of proteins has proven difficult to characterize. The study of homologous proteins with differing thermostabilities offers an especially useful approach for understanding the functional aspects of conformational dynamics. In particular, ribonuclease HI (RNase H, an 18 kD globular protein that hydrolyzes the RNA strand of RNA:DNA hybrid substrates, has been extensively studied by NMR spectroscopy to characterize the differences in dynamics between homologs from the mesophilic organism E. coli and the thermophilic organism T. thermophilus. Herein, molecular dynamics simulations are reported for five homologous RNase H proteins of varying thermostabilities and enzymatic activities from organisms of markedly different preferred growth temperatures. For the E. coli and T. thermophilus proteins, strong agreement is obtained between simulated and experimental values for NMR order parameters and for dynamically averaged chemical shifts, suggesting that these simulations can be a productive platform for predicting the effects of individual amino acid residues on dynamic behavior. Analyses of the simulations reveal that a single residue differentiates between two different and otherwise conserved dynamic processes in a region of the protein known to form part of the substrate-binding interface. Additional key residues within these two categories are identified through the temperature-dependence of these conformational processes.

  16. Visualisation of xanthan conformation by atomic force microscopy.

    Science.gov (United States)

    Moffat, Jonathan; Morris, Victor J; Al-Assaf, Saphwan; Gunning, A Patrick

    2016-09-01

    Direct visual evidence obtained by atomic force microscopy demonstrates that when xanthan is adsorbed from aqueous solution onto the heterogeneously charged substrate mica, its helical conformation is distorted. Following adsorption it requires annealing for several hours to restore its ordered helical state. Once the helix state reforms, the AFM images obtained showed clear resolution of the periodicity with a value of 4.7nm consistent with the previously predicted models. In addition, the images also reveal evidence that the helix is formed by a double strand, a clarification of an ambiguity of the xanthan ultrastructure that has been outstanding for many years. PMID:27185152

  17. MODELING THE CHAIN CONFORMATION OF POLYMER MELTS IN CONTRACTION FLOW

    Institute of Scientific and Technical Information of China (English)

    Qing Shen; Jian-feng Hu; Qing-feng Gu

    2003-01-01

    A constitutive model of quasi-Newtonian fluid based on the type of flow is used in abrupt planar contraction flow.The numerical results from finite element analysis are consistent with experimental data for stress patterns and velocity profiles in the flow field. The chain conformations of polymer melts are then investigated in such a planar contraction by using the phenomenological model with internal parameters proposed by the author. That is, the shape and orientation of polymer chain coils are predicted and discussed in different flow regions of the contraction flow field that possess simple shear flow, extensional flow, vortical flow, and mixed flow respectively.

  18. Using Chemicals to Optimize Conformance Control in Fractured Reservoirs

    Energy Technology Data Exchange (ETDEWEB)

    Seright, Randall S.; Liang, Jenn-Tai; Schrader, Richard; Hagstrom II, John; Wang, Ying; Kumar, Ananad; Wavrik, Kathryn

    2001-10-29

    This report describes work performed during the third and final year of the project, Using Chemicals to Optimize Conformance Control in Fractured Reservoirs. This research project had three objectives. The first objective was to develop a capability to predict and optimize the ability of gels to reduce permeability to water more than that to oil or gas. The second objective was to develop procedures for optimizing blocking agent placement in wells where hydraulic fractures cause channeling problems. The third objective was to develop procedures to optimize blocking agent placement in naturally fractured reservoirs.

  19. Automatic computer-aided system of simulating solder joint formation

    Science.gov (United States)

    Zhao, Xiujuan; Wang, Chunqing; Zheng, Guanqun; Wang, Gouzhong; Yang, Shiqin

    1999-08-01

    One critical aspect in electronic packaging is the fatigue/creep-induced failure in solder interconnections, which is found to be highly dependent on the shape of solder joints. Thus predicting and analyzing the solder joint shape is warranted. In this paper, an automatic computer-aided system is developed to simulate the formation of solder joint and analyze the influence of the different process parameters on the solder joint shape. The developed system is capable of visually designing the process parameters and calculating the solder joint shape automatically without any intervention from the user. The automation achieved will enable fast shape estimation with the variation of process parameters without time consuming experiments, and the simulating system provides the design and manufacturing engineers an efficient software tools to design soldering process in design environment. Moreover, a program developed from the system can serve as the preprocessor for subsequent finite element joint analysis program.

  20. Automatic Emotional State Detection using Facial Expression Dynamic in Videos

    Directory of Open Access Journals (Sweden)

    Hongying Meng

    2014-11-01

    Full Text Available In this paper, an automatic emotion detection system is built for a computer or machine to detect the emotional state from facial expressions in human computer communication. Firstly, dynamic motion features are extracted from facial expression videos and then advanced machine learning methods for classification and regression are used to predict the emotional states. The system is evaluated on two publicly available datasets, i.e. GEMEP_FERA and AVEC2013, and satisfied performances are achieved in comparison with the baseline results provided. With this emotional state detection capability, a machine can read the facial expression of its user automatically. This technique can be integrated into applications such as smart robots, interactive games and smart surveillance systems.

  1. Automated Detection of Conformational Epitopes Using Phage Display Peptide Sequences

    Directory of Open Access Journals (Sweden)

    Surendra S Negi

    2009-01-01

    Full Text Available Background: Precise determination of conformational epitopes of neutralizing antibodies represents a key step in the rational design of novel vaccines. A powerful experimental method to gain insights on the physical chemical nature of conformational epitopes is the selection of linear peptides that bind with high affinities to a monoclonal antibody of interest by phage display technology. However, the structural characterization of conformational epitopes from these mimotopes is not straightforward, and in the past the interpretation of peptide sequences from phage display experiments focused on linear sequence analysis to find a consensus sequence or common sequence motifs.Results: We present a fully automated search method, EpiSearch that predicts the possible location of conformational epitopes on the surface of an antigen. The algorithm uses peptide sequences from phage display experiments as input, and ranks all surface exposed patches according to the frequency distribution of similar residues in the peptides and in the patch. We have tested the performance of the EpiSearch algorithm for six experimental data sets of phage display experiments, the human epidermal growth factor receptor-2 (HER-2/neu, the antibody mAb Bo2C11 targeting the C2 domain of FVIII, antibodies mAb 17b and mAb b12 of the HIV envelope protein gp120, mAb 13b5 targeting HIV-1 capsid protein and 80R of the SARS coronavirus spike protein. In all these examples the conformational epitopes as determined by the X-ray crystal structures of the antibody-antigen complexes, were found within the highest scoring patches of EpiSearch, covering in most cases more than 50% residues of experimental observed conformational epitopes. Input options of the program include mapping of a single peptide or a set of peptides on the antigen structure, and the results of the calculation can be visualized on our interactive web server.Availability: Users can access the EpiSearch from our web

  2. Theoretical prediction of crystal structures of rubrene

    Science.gov (United States)

    Obata, Shigeaki; Miura, Toshiaki; Shimoi, Yukihiro

    2014-01-01

    We theoretically predict crystal structures and molecular arrangements for rubrene molecule using CONFLEX program and compare them with the experimental ones. The most, second-most, and fourth-most stable predicted crystal structures show good agreement with the triclinic, orthorhombic, and monoclinic polymorphs of rubrene, respectively. The change in molecular conformation is also predicted between crystalline and gas phases: the tetracene backbone takes flat conformation in crystalline phase as in the observed structure. Meanwhile, it is twisted in gas phase. The theoretical prediction method used in this work provides the successful results on the determination of the three kinds of crystal structures and molecular arrangements for rubrene molecule.

  3. Conformal Gravity: Dark Matter and Dark Energy

    CERN Document Server

    Nesbet, Robert K

    2012-01-01

    This short review examines recent progress in understanding dark matter, dark energy, and galactic halos using theory that departs minimally from standard particle physics and cosmology. Postulated strict conformal symmetry (local Weyl scaling covariance) for all elementary massless fields retains standard theory for fermions and gauge bosons but modifies Einstein-Hilbert general relativity and the Higgs scalar field model, introducing no new physical fields. Subgalactic phenomenology is retained. Without invoking dark matter, conformal gravity and a conformal Higgs model fit empirical data on galactic rotational velocities, galactic halos, and Hubble expansion including dark energy.

  4. Scalar scattering via conformal higher spin exchange

    CERN Document Server

    Joung, E; Tseytlin, A A

    2015-01-01

    Theories containing infinite number of higher spin fields require a particular definition of summation over spins consistent with their underlying symmetries. We consider a model of massless scalars interacting (via bilinear conserved currents) with conformal higher spin fields in flat space. We compute the tree-level four-scalar scattering amplitude using a natural prescription for summation over an infinite set of conformal higher spin exchanges and find that it vanishes. Independently, we show that the vanishing of the scalar scattering amplitude is, in fact, implied by the global conformal higher spin symmetry of this model. We also discuss one-loop corrections to the four-scalar scattering amplitude.

  5. Mapping the conformations of biological assemblies

    CERN Document Server

    Schwander, P; Phillips, G N; Jr.,; Ourmazd, A

    2009-01-01

    Mapping conformational heterogeneity of macromolecules presents a formidable challenge to X-ray crystallography and cryo-electron microscopy, which often presume its absence. This has severely limited our knowledge of the conformations assumed by biological systems and their role in biological function, even though they are known to be important. We propose a new approach to determining to high resolution the three-dimensional conformations of biological entities such as molecules, macromolecular assemblies, and ultimately cells, with existing and emerging experimental techniques. This approach may also enable one to circumvent current limits due to radiation damage and solution purification.

  6. Conformal Gravity: Dark Matter and Dark Energy

    Directory of Open Access Journals (Sweden)

    Robert K. Nesbet

    2013-01-01

    Full Text Available This short review examines recent progress in understanding dark matter, dark energy, and galactic halos using theory that departs minimally from standard particle physics and cosmology. Strict conformal symmetry (local Weyl scaling covariance, postulated for all elementary massless fields, retains standard fermion and gauge boson theory but modifies Einstein–Hilbert general relativity and the Higgs scalar field model, with no new physical fields. Subgalactic phenomenology is retained. Without invoking dark matter, conformal gravity and a conformal Higgs model fit empirical data on galactic rotational velocities, galactic halos, and Hubble expansion including dark energy.

  7. Scalar scattering via conformal higher spin exchange

    Science.gov (United States)

    Joung, Euihun; Nakach, Simon; Tseytlin, Arkady A.

    2016-02-01

    Theories containing infinite number of higher spin fields require a particular definition of summation over spins consistent with their underlying symmetries. We consider a model of massless scalars interacting (via bilinear conserved currents) with conformal higher spin fields in flat space. We compute the tree-level four-scalar scattering amplitude using a natural prescription for summation over an infinite set of conformal higher spin exchanges and find that it vanishes. Independently, we show that the vanishing of the scalar scattering amplitude is, in fact, implied by the global conformal higher spin symmetry of this model. We also discuss one-loop corrections to the four-scalar scattering amplitude.

  8. Conformal symmetry of JIMWLK evolution at NLO

    International Nuclear Information System (INIS)

    We construct the Next to Leading Order JIMWLK Hamiltonian for high energy evolution in N=4 SUSY theory, and show that it possesses conformal invariance, even though it is derived using sharp cutoff on rapidity variable. The conformal transformation properties of Wilson lines are not quite the naive ones, but at NLO acquire an additional anomalous piece. We construct explicitly the inversion symmetry generator. We also show how to construct for every operator O, including the Hamiltonian itself, its “conformal extension' O, such that it transforms under the inversion in the naive way

  9. The decomposition of global conformal invariants

    CERN Document Server

    Alexakis, Spyros

    2012-01-01

    This book addresses a basic question in differential geometry that was first considered by physicists Stanley Deser and Adam Schwimmer in 1993 in their study of conformal anomalies. The question concerns conformally invariant functionals on the space of Riemannian metrics over a given manifold. These functionals act on a metric by first constructing a Riemannian scalar out of it, and then integrating this scalar over the manifold. Suppose this integral remains invariant under conformal re-scalings of the underlying metric. What information can one then deduce about the Riemannian scalar? Dese

  10. Singular vectors in logarithmic conformal field theories

    International Nuclear Information System (INIS)

    Null vectors are generalized to the case of indecomposable representations which are one of the main features of logarithmic conformal field theories. This is done by developing a compact formalism with the particular advantage that the stress energy tensor acting on Jordan cells of primary fields and their logarithmic partners can still be represented in form of linear differential operators. Since the existence of singular vectors is subject to much stronger constraints than in regular conformal field theory, they also provide a powerful tool for the classification of logarithmic conformal field theories. (orig.)

  11. Conformable Fractional Nikiforov—Uvarov Method

    Science.gov (United States)

    Karayer, H.; Demirhan, D.; Büyükkılıç, F.

    2016-07-01

    We introduce conformable fractional Nikiforov—Uvarov (NU) method by means of conformable fractional derivative which is the most natural definition in non-integer calculus. Since, NU method gives exact eigenstate solutions of Schrödinger equation (SE) for certain potentials in quantum mechanics, this method is carried into the domain of fractional calculus to obtain the solutions of fractional SE. In order to demonstrate the applicability of the conformable fractional NU method, we solve fractional SE for harmonic oscillator potential, Woods—Saxon potential, and Hulthen potential.

  12. Intermediate leak protection/automatic shutdown for B and W helical coil steam generator

    International Nuclear Information System (INIS)

    The report summarizes a follow-on study to the multi-tiered Intermediate Leak/Automatic Shutdown System report. It makes the automatic shutdown system specific to the Babcock and Wilcox (B and W) helical coil steam generator and to the Large Development LMFBR Plant. Threshold leak criteria specific to this steam generator design are developed, and performance predictions are presented for a multi-tier intermediate leak, automatic shutdown system applied to this unit. Preliminary performance predictions for application to the helical coil steam generator were given in the referenced report; for the most part, these predictions have been confirmed. The importance of including a cover gas hydrogen meter in this unit is demonstrated by calculation of a response time one-fifth that of an in-sodium meter at hot standby and refueling conditions

  13. Solid state conformational classification of eight-membered rings

    DEFF Research Database (Denmark)

    Pérez, J.; García, L.; Kessler, M.;

    2005-01-01

    A statistical classification of the solid state conformation in the title complexes using data retrieved from the Cambridge Structural Database (CSD) has been made. Phosphate and phosphinate complexes show a chair conformation preferably. In phosphonate complexes, the most frequent conformations ...

  14. Conformal chiral boson models on twisted doubled tori and non-geometric string vacua

    CERN Document Server

    Avramis, Spyros D; Prezas, Nikolaos

    2009-01-01

    We derive and analyze the conditions for quantum conformal and Lorentz invariance of the duality symmetric interacting chiral boson sigma-models, which are conjectured to describe non-geometric string theory backgrounds. The one-loop Weyl and Lorentz anomalies are computed for the general case using the background field method. Subsequently, our results are applied to a class of (on-shell) Lorentz invariant chiral boson models which are based on twisted doubled tori. Our findings are in agreement with those expected from the effective supergravity approach, thereby firmly establishing that the chiral boson models under consideration provide the string worldsheet description of N=4 gauged supergravities with electric gaugings. Furthermore, they demonstrate that twisted doubled tori are indeed the doubled internal geometries underlying a large class of non-geometric string compactifications. For compact gaugings the associated chiral boson models are automatically conformal, a fact that is explained by showing ...

  15. Conformation-independent structural comparison of macromolecules with ProSMART

    Energy Technology Data Exchange (ETDEWEB)

    Nicholls, Robert A., E-mail: nicholls@mrc-lmb.cam.ac.uk [MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH (United Kingdom); Fischer, Marcus [University of California San Francisco, San Francisco, CA 94158 (United States); McNicholas, Stuart [University of York, Heslington, York YO10 5DD (United Kingdom); Murshudov, Garib N. [MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH (United Kingdom)

    2014-09-01

    The Procrustes Structural Matching Alignment and Restraints Tool (ProSMART) has been developed to allow local comparative structural analyses independent of the global conformations and sequence homology of the compared macromolecules. This allows quick and intuitive visualization of the conservation of backbone and side-chain conformations, providing complementary information to existing methods. The identification and exploration of (dis)similarities between macromolecular structures can help to gain biological insight, for instance when visualizing or quantifying the response of a protein to ligand binding. Obtaining a residue alignment between compared structures is often a prerequisite for such comparative analysis. If the conformational change of the protein is dramatic, conventional alignment methods may struggle to provide an intuitive solution for straightforward analysis. To make such analyses more accessible, the Procrustes Structural Matching Alignment and Restraints Tool (ProSMART) has been developed, which achieves a conformation-independent structural alignment, as well as providing such additional functionalities as the generation of restraints for use in the refinement of macromolecular models. Sensible comparison of protein (or DNA/RNA) structures in the presence of conformational changes is achieved by enforcing neither chain nor domain rigidity. The visualization of results is facilitated by popular molecular-graphics software such as CCP4mg and PyMOL, providing intuitive feedback regarding structural conservation and subtle dissimilarities between close homologues that can otherwise be hard to identify. Automatically generated colour schemes corresponding to various residue-based scores are provided, which allow the assessment of the conservation of backbone and side-chain conformations relative to the local coordinate frame. Structural comparison tools such as ProSMART can help to break the complexity that accompanies the constantly growing

  16. ANPS - AUTOMATIC NETWORK PROGRAMMING SYSTEM

    Science.gov (United States)

    Schroer, B. J.

    1994-01-01

    Development of some of the space program's large simulation projects -- like the project which involves simulating the countdown sequence prior to spacecraft liftoff -- requires the support of automated tools and techniques. The number of preconditions which must be met for a successful spacecraft launch and the complexity of their interrelationship account for the difficulty of creating an accurate model of the countdown sequence. Researchers developed ANPS for the Nasa Marshall Space Flight Center to assist programmers attempting to model the pre-launch countdown sequence. Incorporating the elements of automatic programming as its foundation, ANPS aids the user in defining the problem and then automatically writes the appropriate simulation program in GPSS/PC code. The program's interactive user dialogue interface creates an internal problem specification file from user responses which includes the time line for the countdown sequence, the attributes for the individual activities which are part of a launch, and the dependent relationships between the activities. The program's automatic simulation code generator receives the file as input and selects appropriate macros from the library of software modules to generate the simulation code in the target language GPSS/PC. The user can recall the problem specification file for modification to effect any desired changes in the source code. ANPS is designed to write simulations for problems concerning the pre-launch activities of space vehicles and the operation of ground support equipment and has potential for use in developing network reliability models for hardware systems and subsystems. ANPS was developed in 1988 for use on IBM PC or compatible machines. The program requires at least 640 KB memory and one 360 KB disk drive, PC DOS Version 2.0 or above, and GPSS/PC System Version 2.0 from Minuteman Software. The program is written in Turbo Prolog Version 2.0. GPSS/PC is a trademark of Minuteman Software. Turbo Prolog

  17. Conformational design optimization of transcription factor beacon DNA biosensors

    Directory of Open Access Journals (Sweden)

    Stephen R. Schaffner

    2014-12-01

    Full Text Available Widespread application of promising DNA-based transcription factor protein (TF biosensors is limited by our ability to control their binding properties. Because the binding properties of this class of biosensors are affected by how well the biosensor switches between binding and non-binding conformations, we investigated the effects of varying conformational stability on the ability of biosensors to detect the oncologically-relevant Myc/Max TF dimer complex. To do this, we employed a custom algorithm that designed and evaluated possible biosensors based on the Myc/Max TF recognition sequence, choosing algorithmic parameters that selected for biosensors with varied conformational stability due to changes in stem length. Biosensors with recognition stem lengths of 8 base pairs (bp, 12 bp, or 21 bp were selected and synthesized. Biosensor binding affinity changes and kinetic association rates were found to be significantly affected by changes in conformational stability (with binding affinity increasing with stem length, from 80 ± 20 nM to 440 ± 80 nM, and kinetic switching rate being tenfold impacted in the longer biosensors. These results show that increased stability can have significant inverse effects on overall biosensor performance, providing important implications for effective biosensor designs. We applied these design insights to generate a biosensor that tested and confirmed a predicted in vivo interaction between two TFs (ATF3 and Max, illustrating the potential for rationally-designed, TF-detecting biosensors as a routine analytical tool.

  18. Film dosimetry in conformal radiotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Danciu, C.; Proimos, B.S. [Patras Univ. (Greece). Dept. of Medical Physics

    1995-12-01

    Dosimetry, through a film sandwiched in a transverse cross-section of a solid phantom, is a method of choice in Conformal Radiotherapy because: (a) the blackness (density) of the film at each point offers a measure of the total dose received at that point, and (b) the film is easily calibrated by exposing a film strip in the same cross-section, through a stationary field. The film must therefore have the following properties: (a) it must be slow, in order not to be overexposed, even at a therapeutic dose of 200 cGy, and (b) the response of the film (density versus dose curve) must be independent of the photon energy spectrum. A few slow films were compared. It was found that the Kodak X-Omat V for therapy verification was the best choice. To investigate whether the film response was independent of the photon energy, response curves for six depths, starting from the depth of maximum dose to the depth of 25 cm, in solid phantom were derived. The vertical beam was perpendicular to the anterior surface of the phantom, which was at the distance of 100 cm from the source and the field was 15x15 cm at that distance. This procedure was repeated for photon beams emitted by a Cobalt-60 unit, two 6 MV and 15 MV Linear Accelerators, as well as a 45 MV Betatron. For each of those four different beams the film response was the same for all six depths. The results, as shown in the diagrams, are very satisfactory. The response curve under a geometry similar to that actually applied, when the film is irradiated in a transverse cross-section of the phantom, was derived. The horizontal beam was almost parallel (angle of 85) to the plane of the film. The same was repeated with the central ray parallel to the film (angle 90) and at a distance of 1.5 cm from the horizontal film. The field size was again 15x15 at the lateral entrance surface of the beam. The response curves remained the same, as when the beam was perpendicular to the films.

  19. Autoclass: An automatic classification system

    Science.gov (United States)

    Stutz, John; Cheeseman, Peter; Hanson, Robin

    1991-01-01

    The task of inferring a set of classes and class descriptions most likely to explain a given data set can be placed on a firm theoretical foundation using Bayesian statistics. Within this framework, and using various mathematical and algorithmic approximations, the AutoClass System searches for the most probable classifications, automatically choosing the number of classes and complexity of class descriptions. A simpler version of AutoClass has been applied to many large real data sets, has discovered new independently-verified phenomena, and has been released as a robust software package. Recent extensions allow attributes to be selectively correlated within particular classes, and allow classes to inherit, or share, model parameters through a class hierarchy. The mathematical foundations of AutoClass are summarized.

  20. Automatic summarising factors and directions

    CERN Document Server

    Jones, K S

    1998-01-01

    This position paper suggests that progress with automatic summarising demands a better research methodology and a carefully focussed research strategy. In order to develop effective procedures it is necessary to identify and respond to the context factors, i.e. input, purpose, and output factors, that bear on summarising and its evaluation. The paper analyses and illustrates these factors and their implications for evaluation. It then argues that this analysis, together with the state of the art and the intrinsic difficulty of summarising, imply a nearer-term strategy concentrating on shallow, but not surface, text analysis and on indicative summarising. This is illustrated with current work, from which a potentially productive research programme can be developed.

  1. Automatic Sequencing for Experimental Protocols

    Science.gov (United States)

    Hsieh, Paul F.; Stern, Ivan

    We present a paradigm and implementation of a system for the specification of the experimental protocols to be used for the calibration of AXAF mirrors. For the mirror calibration, several thousand individual measurements need to be defined. For each measurement, over one hundred parameters need to be tabulated for the facility test conductor and several hundred instrument parameters need to be set. We provide a high level protocol language which allows for a tractable representation of the measurement protocol. We present a procedure dispatcher which automatically sequences a protocol more accurately and more rapidly than is possible by an unassisted human operator. We also present back-end tools to generate printed procedure manuals and database tables required for review by the AXAF program. This paradigm has been tested and refined in the calibration of detectors to be used in mirror calibration.

  2. Conformal Symmetries of Adiabatic Modes in Cosmology

    CERN Document Server

    Hinterbichler, Kurt; Khoury, Justin

    2012-01-01

    We remark on the existence of non-linearly realized conformal symmetries for scalar adiabatic perturbations in cosmology. These conformal symmetries are present for any cosmological background, beyond any slow-roll or quasi-de Sitter approximation. The dilatation transformation shifts the curvature perturbation by a constant, and corresponds to the well-known symmetry under spatial rescaling. We argue that the scalar sector is also invariant under special conformal transformations, which shift the curvature perturbation by a term linear in the spatial coordinates. We discuss whether these conformal symmetries can be extended to include tensor perturbations. Tensor modes introduce their own set of non-linearly realized symmetries. We identify an infinite set of large gauge transformations which maintain the transverse, traceless gauge condition, while shifting the tensor mode non-trivially.

  3. Singular solutions of fractional order conformal Laplacians

    CERN Document Server

    Gonzalez, Maria del Mar; Sire, Yannick

    2009-01-01

    We investigate the singular sets of solutions of conformally covariant elliptic operators of fractional order with the goal of developing generalizations of some well-known properties of solutions of the singular Yamabe problem.

  4. N=1 SUSY Conformal Block Recursive Relations

    CERN Document Server

    Belavin, V A

    2006-01-01

    We present explicit recursive relations for the four-point superconformal block functions that are essentially particular contributions of the given conformal class to the four-point correlation function. The approach is based on the analytic properties of the superconformal blocks as functions of the conformal dimensions and the central charge of the superconformal algebra. The results are compared with the explicit analytic expressions obtained for special parameter values corresponding to the truncated operator product expansion. These recursive relations are an efficient tool for numerically studying the four--point correlation function in Super Conformal Field Theory in the framework of the bootstrap approach, similar to that in the case of the purely conformal symmetry.

  5. Synthesis and conformational features of sym ,',"-triarylguanidines

    Indian Academy of Sciences (India)

    Kanniyappan Gopi; Brijesh Rathi; Natesan Thirupathi

    2010-03-01

    A one pot reaction involving sym ,'-diarylthiourea and the respective arylamine in the presence of aq. KOH in nitrobenzene at ≥ 105°C afforded sym ,',"-triarylguanidine in fair to good yield and the products have been characterized. Sym ,',"-tri(4-tolyl)guanidine possesses (7) anti-anti conformation, sym ,',"-tri(2-tolyl)guanidine (8) and sym ,',"-tris(2,4-xylyl)guanidine (11) each possess anti-anti conformation whereas sym ,',"-tris(2-anisyl)guanidine possesses (9) syn-anti conformation as determined by single crystal X-ray diffraction data. The observed conformations appear to result from a subtle balance between steric factor associated with the aryl substituent and multiple electronic factors namely - conjugation/negative hyperconjugation and non-covalent interactions in the crystal lattice.

  6. On Functional Representations of the Conformal Algebra

    CERN Document Server

    Rosten, Oliver J

    2014-01-01

    Starting with conformally covariant correlation functions, a sequence of functional representations of the conformal algebra is constructed. A key step is the introduction of representations which involve an auxiliary functional. It is observed that these functionals are not arbitrary but rather must satisfy a pair of consistency equations; one such is identified, in a particular representation, as an Exact Renormalization Group equation specialized to a fixed-point. Therefore, the associated functional is identified with the Wilsonian Effective Action and this creates a concrete link between action-free formulations of Conformal Field Theory and the cutoff-regularized path integral approach. Following this, the energy-momentum tensor is investigated, from which it becomes apparent that the conformal Ward Identities serve to define a particular representation of the energy-momentum tensor. It follows, essentially trivially, that if the Schwinger functional exists and is non-vanishing then theories exhibiting ...

  7. Quantum Integrable Systems from Conformal Blocks

    CERN Document Server

    Chen, Heng-Yu

    2016-01-01

    In this note, we extend the striking connections between quantum integrable systems and conformal blocks recently found in http://arxiv.org/abs/1602.01858 in several directions. First, we explicitly demonstrate that the action of quartic conformal Casimir operator on general d-dimensional scalar conformal blocks, can be expressed in terms of certain combinations of commuting integrals of motions of the two particle hyperbolic BC2 Calogero-Sutherland system. The permutation and reflection properties of the underlying Dunkl operators play crucial roles in establishing such a connection. Next, we show that the scalar superconformal blocks in SCFTs with four and eight supercharges and suitable chirality constraints can also be identified with the eigenfunctions of the same Calogero-Sutherland system, this demonstrates the universality of such a connection. Finally, we observe that the so-called "seed" conformal blocks for constructing four point functions for operators with arbitrary space-time spins in four dime...

  8. Generalized additivity in unitary conformal field theories

    Directory of Open Access Journals (Sweden)

    Gideon Vos

    2015-10-01

    Full Text Available It was demonstrated in [2,12] that d=4 unitary CFT's satisfy a special property: if a scalar operator with conformal dimension Δ exists in the operator spectrum, then the conformal bootstrap demands that large spin primary operators have to exist in the operator spectrum of the CFT with a conformal twist close to 2Δ+2N for any integer N. In this paper the conformal bootstrap methods in [1] that were used to find the anomalous dimension of the N=0 operators have been generalized to recursively find the anomalous dimension of all large spin operators of this class. In AdS these operators can be interpreted as the excited states of the product states of objects that were found in other works.

  9. Parametric dependence of irregular conformal block

    CERN Document Server

    Choi, Sang-Kwan

    2013-01-01

    Irregular conformal block is an important tool to study a new type of conformal theories, which can be constructed as the colliding limit of the regular conformal block. The irregular conformal block is realized as the $\\beta$-deformed Penner matrix model whose partition function is regarded as the inner product of the irregular modules. The parameter dependence of the inner product is obtained explicitly using the loop equation with close attention to singularities in the parameter space. It is noted that the exact singular structure of the parameter space in general can be found using a very simple and powerful method which uses the flow equations of the partition function together with the hierarchical structure of the singularity. This method gives the exact expression to all orders of large $N$ expansion without using the explicit contour integral of the filling fraction.

  10. Structure of The Planar Galilean Conformal Algebra

    Science.gov (United States)

    Gao, Shoulan; Liu, Dong; Pei, Yufeng

    2016-08-01

    In this paper, we compute the low-dimensional cohomology groups of the planar Galilean conformal algebra introduced by Bagchi and Goparkumar. Consequently we determine its derivations, central extensions, and automorphisms.

  11. Definite signature conformal holonomy: a complete classification

    OpenAIRE

    Armstrong, Stuart

    2005-01-01

    This paper aims to classify the holonomy of the conformal Tractor connection, and relate these holonomies to the geometry of the underlying manifold. The conformally Einstein case is dealt with through the construction of metric cones, whose Riemmanian holonomy is the same as the Tractor holonomy of the underlying manifold. Direct calculations in the Ricci-flat case and an important decomposition theorem complete the classification for definitive signature.

  12. de Sitter entropy from conformal field theory

    CERN Document Server

    Kabat, D; Kabat, Daniel; Lifschytz, Gilad

    2002-01-01

    We propose that the entropy of de Sitter space can be identified with the mutual entropy of a dual conformal field theory. We argue that unitary time evolution in de Sitter space restricts the total number of excited degrees of freedom to be bounded by the de Sitter entropy, and we give a CFT interpretation of this restriction. We also clarify issues arising from the fact that both de Sitter and anti de Sitter have dual descriptions in terms of conformal field theory.

  13. Geometry and conformations of benzenecarboxylic acids

    OpenAIRE

    IVAN GUTMAN; DALIBOR BADJUK; ZORAN MARKOVIC

    2004-01-01

    The geometry, conformations and energy of mono-, di-, and tri-carboxylic derivatives of benzene were studied by means of the AM1 molecular-orbital method. Whereas the species having no carboxylic groups in the ortho-position (benzoic, isophthalic, terephthalic, and trimesic acids) are planar in all their (stable) conformations, those possessing carboxylic groups in the ortho-position (phthalic, 1,2,3-benzenetricarboxylic, and 1,2,4-benzenetricarboxylic acids) assume a non-planar geometry, wit...

  14. Entanglement entropy, conformal invariance and extrinsic geometry

    OpenAIRE

    Solodukhin, Sergey N.

    2008-01-01

    We use the conformal invariance and the holographic correspondence to fully specify the dependence of entanglement entropy on the extrinsic geometry of the 2d surface $\\Sigma$ that separates two subsystems of quantum strongly coupled ${\\mathcal{N}}=4$ SU(N) superconformal gauge theory. We extend this result and calculate entanglement entropy of a generic 4d conformal field theory. As a byproduct, we obtain a closed-form expression for the entanglement entropy in flat space-time when $\\Sigma$ ...

  15. The conformal transformation of the night sky

    CERN Document Server

    Minguzzi, E

    2016-01-01

    We give a simple differential geometric proof of the conformal transformation of the night sky under change of observer. The proof does not rely on the four dimensionality of spacetime or on spinor methods. Furthermore, it really shows that the result does not depend on Lorentz transformations. This approach, by giving a transparent covariant expression to the conformal factor, shows that in most situations it is possible to define a thermal sky metric independent of the observer.

  16. Conformal transformation of tetrads and spin connection

    CERN Document Server

    Chakrabarty, Subhasish

    2016-01-01

    We investigate the conformal transformation of vierbein-Einstein-Palatini (VEP) action in terms of tetrads $e^I_\\mu$ and spin connection $A^{IJ}_\\mu$. The transformation of tetrads is obtained from that of the spacetime metric whereas that of the spin connection is not unique off-shell. When the connection can be completely expressed in terms of the tetrads, its transformation follows from that of the tetrads. We also construct the conformally invariant scalar field in the VEP formalism.

  17. Topological Black Holes in Weyl Conformal Gravity

    OpenAIRE

    Klemm, Dietmar

    1998-01-01

    We present a class of exact solutions of Weyl conformal gravity, which have an interpretation as topological black holes. Solutions with negative, zero or positive scalar curvature at infinity are found, the former generalizing the well-known topological black holes in anti-de Sitter gravity. The rather delicate question of thermodynamic properties of such objects in Weyl conformal gravity is discussed; suggesting that the thermodynamics of the found solutions should be treated within the fra...

  18. Social influences towards conformism in economic experiments

    OpenAIRE

    Hargreaves Heap, Shaun P.

    2014-01-01

    This paper reviews some of the economic experimental evidence on conformism. There is nothing to match the early psychology experiments where subjects were often swayed by the behaviour of others to an extraordinary degree, but there is plenty of evidence of conformism. This seems built-in to our sociality either because we have preferences for conversation or status which are activated by the knowledge of what others do, or because other people face relevantly similar decisions to our own an...

  19. Conformally Invariant Spinorial Equations in Six Dimensions

    CERN Document Server

    Batista, Carlos

    2016-01-01

    This work deals with the conformal transformations in six-dimensional spinorial formalism. Several conformally invariant equations are obtained and their geometrical interpretation are worked out. Finally, the integrability conditions for some of these equations are established. Moreover, in the course of the article, some useful identities involving the curvature of the spinorial connection are attained and a digression about harmonic forms and more general massless fields is made.

  20. Visually Guided Robotics Using Conformal Geometric Computing

    OpenAIRE

    Bayro-Corrochano, Eduardo; Falcon-Morales, Luis Eduardo; Zamora-Esquivel, Julio

    2007-01-01

    In this chapter the authors have used a single non?standard mathematical framework, the Conformal Geometric Algebra, in order to simplify the set of data structures that we usually use with the traditional methods. The key idea is to define and use a set of products in CGA that will be enough to generate conformal transformations, manifolds as ruled surfaces and develop incidence algebra operations, as well as solve equations and obtain directed distances between different kinds of geometric ...

  1. On the stochastic dynamics of molecular conformation

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    An important functioning mechanism of biological macromolecules is the transition between different conformed states due to thermal fluctuation. In the present paper, a biological macromolecule is modeled as two strands with side chains facing each other, and its stochastic dynamics including the statistics of stationary motion and the statistics of conformational transition is studied by using the stochastic averaging method for quasi Hamiltonian systems. The theoretical results are confirmed with the results from Monte Carlo simulation.

  2. Transformations among large c conformal field theories

    OpenAIRE

    Jankiewicz, Marcin M.; Kephart, Thomas W.

    2005-01-01

    We show that there is a set of transformations that relates all of the 24 dimensional even self-dual (Niemeier) lattices, and also leads to non-lattice objects that however cannot be interpreted as a basis for the construction of holomorphic conformal field theory. In the second part of this paper, we extend our observations to higher dimensional conformal field theories build on extremal partition functions, where we generate c=24k theories with spectra decomposable into the irreducible repr...

  3. A New Type of Conformal Dynamics

    OpenAIRE

    Stichel, P. C.; Zakrzewski, W. J.

    2003-01-01

    We consider the Lagrangian particle model introduced in [hep-th/9612017] for zero mass but nonvanishing second central charge of the planar Galilei group. Extended by a magnetic vortex or a Coulomb potential the model exibits conformal symmetry. In the former case we observe an additional SO(2,1) hidden symmetry. By either a canonical transformation with constraints or by freezing scale and special conformal transformations at $t=0$ we reduce the six-dimensional phase-space to the physically ...

  4. Conformal symmetry and light flavor baryon spectra

    CERN Document Server

    Kirchbach, M

    2010-01-01

    The degeneracy among parity pairs systematically observed in the N and Delta spectra is interpreted as signature for conformal symmetry realization in the light flavor baryon sector in consequence of AdS/CFT. The case is made by showing that all the observed N and Delta resonances with masses below 2500 MeV distribute fairly well over the first levels of a unitary representation of the conformal group, a representation that covers the spectrum of a quark-diquark system, placed directly on the AdS_5 cone, conformally compactified to R^1*S^3. The free geodesic motion on the S^3 manifold is described by means of the scalar conformal equation there, which is of the Klein-Gordon type. The equation is then gauged by the "curved" Coulomb potential that has the form of a cotangent function. Conformal symmetry is not exact, this because the gauge potential slightly modifies the conformal centrifugal barrier of the free geodesic motion. Thanks to this, the degeneracy between P11-S11 pairs from same level is relaxed, wh...

  5. Conformational properties of oxazoline-amino acids

    Science.gov (United States)

    Staś, Monika; Broda, Małgorzata A.; Siodłak, Dawid

    2016-04-01

    Oxazoline-amino acids (Xaa-Ozn) occur in natural peptides of potentially important bioactivity. The conformations of the model compounds: Ac-(S)-Ala-Ozn(4R-Me), Ac-(S)-Ala-Ozn(4S-Me), and (gauche+, gauche-, anti) Ac-(S)-Val-Ozn(4R-Me) were studied at meta-hybrid M06-2X/6-311++G(d,p) method including solvent effect. Boc-L-Ala-L-Ozn-4-COOMe and Boc-L-Val-L-Ozn-4-COOMe were synthesized and studied by FT-IR and NMR-NOE methods. The conformations in crystal state were gathered from the Cambridge Structural Data Base. The main conformational feature of the oxazoline amino acids is the conformation β2 (ϕ,ψ ∼ -161°, -6°), which predominates in weakly polar environment and still is accessible in polar surrounding. The changes of the conformational preferences towards the conformations αR (ϕ,ψ ∼ -70°, -15°) and then β (ϕ,ψ ∼ -57°, -155°) are observed with increase of the environment polarity.

  6. Structures and Rotational Barriers of a Diiodobinorsnoutane: Energetic Preference for Gauche Conformation.

    Science.gov (United States)

    Herres, Joseph P; Moran, Caitlin A; Forman, Mark A; Hall, James E; McCauley, John P; Pivonka, Don E; Wesolowski, Steven S

    2016-08-01

    The diiodobinorsnoutane, bi(5-iodopentacyclo[4.3.0.0(2,4).0(3,8).0(5,7)]non-4-yl) (5), exists in a sterically hindered gauche conformation rather than an anti or an averaged (freely rotating) C2v structure. Density functional theory (DFT) predictions place the gauche conformation 11 kcal/mol more stable than the anti conformation with a barrier of 17 kcal/mol connecting the minima. These are consistent with variable-temperature NMR (17.1 ± 0.8 kcal/mol) estimates and X-ray analysis. Predictions of the torsional profiles of the yet-unsynthesized bromo-, chloro-, and fluoro- analogues show a progressive lowering of the barriers. PMID:27391283

  7. Theoretical studies on the possible conformers and properties of tetranitrodiazidoacetylhexaazaisowurtzitane (TNDAIW)

    Institute of Scientific and Technical Information of China (English)

    WU; Yukai; OU; Yuxiang; LIU; Zhiguo; LIU; Jinquan; MENG; Zh

    2004-01-01

    Tetranitrodiazidoacetylhexaazaisowurtzitane (TNDAIW) is a novel polyazapolycyclic caged polyazidonitramine explosive first synthesized in our laboratory. All of the possible conformers of TNDAIW are optimized using both the AM1 and PM3 methods. TNDAIW is predicted to have more polymorphs than hexanitrohexaazoisowurtzitane (CL-20). The HF/6-31G(d) level of theory is used to investigate the lowest energy structures of D-TNDAIW for both AM1 and PM3.The possible conformers of TNDAIW are predicted to be more stable than epsilon-CL-20 based on the N-NO2 bond lengths. The impact and shock sensitivities of both the possible DA- and DP-TNDAIW are lower than the corresponding ones of epsilon-CL-20. TNDAIW with the possible conformers is estimated to be a promising novel high energy density explosive.

  8. Finite element fatigue analysis of rectangular clutch spring of automatic slack adjuster

    Science.gov (United States)

    Xu, Chen-jie; Luo, Zai; Hu, Xiao-feng; Jiang, Wen-song

    2015-02-01

    The failure of rectangular clutch spring of automatic slack adjuster directly affects the work of automatic slack adjuster. We establish the structural mechanics model of automatic slack adjuster rectangular clutch spring based on its working principle and mechanical structure. In addition, we upload such structural mechanics model to ANSYS Workbench FEA system to predict the fatigue life of rectangular clutch spring. FEA results show that the fatigue life of rectangular clutch spring is 2.0403×105 cycle under the effect of braking loads. In the meantime, fatigue tests of 20 automatic slack adjusters are carried out on the fatigue test bench to verify the conclusion of the structural mechanics model. The experimental results show that the mean fatigue life of rectangular clutch spring is 1.9101×105, which meets the results based on the finite element analysis using ANSYS Workbench FEA system.

  9. Solar Powered Automatic Shrimp Feeding System

    Directory of Open Access Journals (Sweden)

    Dindo T. Ani

    2015-12-01

    Full Text Available - Automatic system has brought many revolutions in the existing technologies. One among the technologies, which has greater developments, is the solar powered automatic shrimp feeding system. For instance, the solar power which is a renewable energy can be an alternative solution to energy crisis and basically reducing man power by using it in an automatic manner. The researchers believe an automatic shrimp feeding system may help solve problems on manual feeding operations. The project study aimed to design and develop a solar powered automatic shrimp feeding system. It specifically sought to prepare the design specifications of the project, to determine the methods of fabrication and assembly, and to test the response time of the automatic shrimp feeding system. The researchers designed and developed an automatic system which utilizes a 10 hour timer to be set in intervals preferred by the user and will undergo a continuous process. The magnetic contactor acts as a switch connected to the 10 hour timer which controls the activation or termination of electrical loads and powered by means of a solar panel outputting electrical power, and a rechargeable battery in electrical communication with the solar panel for storing the power. By undergoing through series of testing, the components of the modified system were proven functional and were operating within the desired output. It was recommended that the timer to be used should be tested to avoid malfunction and achieve the fully automatic system and that the system may be improved to handle changes in scope of the project.

  10. Automatic control of nuclear power plants

    International Nuclear Information System (INIS)

    The fundamental concepts in automatic control are surveyed, and the purpose of the automatic control of pressurized water reactors is given. The response characteristics for the main components are then studied and block diagrams are given for the main control loops (turbine, steam generator, and nuclear reactors)

  11. Automatic segmentation of diatom images for classification

    NARCIS (Netherlands)

    Jalba, Andrei C.; Wilkinson, Michael H.F.; Roerdink, Jos B.T.M.

    2004-01-01

    A general framework for automatic segmentation of diatom images is presented. This segmentation is a critical first step in contour-based methods for automatic identification of diatoms by computerized image analysis. We review existing results, adapt popular segmentation methods to this difficult p

  12. Automatic Performance Debugging of SPMD Parallel Programs

    CERN Document Server

    Liu, Xu; Zhan, Jianfeng; Tu, Bibo; Meng, Dan

    2010-01-01

    Automatic performance debugging of parallel applications usually involves two steps: automatic detection of performance bottlenecks and uncovering their root causes for performance optimization. Previous work fails to resolve this challenging issue in several ways: first, several previous efforts automate analysis processes, but present the results in a confined way that only identifies performance problems with apriori knowledge; second, several tools take exploratory or confirmatory data analysis to automatically discover relevant performance data relationships. However, these efforts do not focus on locating performance bottlenecks or uncovering their root causes. In this paper, we design and implement an innovative system, AutoAnalyzer, to automatically debug the performance problems of single program multi-data (SPMD) parallel programs. Our system is unique in terms of two dimensions: first, without any apriori knowledge, we automatically locate bottlenecks and uncover their root causes for performance o...

  13. AUTOMATIC DESIGNING OF POWER SUPPLY SYSTEMS

    Directory of Open Access Journals (Sweden)

    A. I. Kirspou

    2016-01-01

    Full Text Available Development of automatic designing system for power supply of industrial enterprises is considered in the paper. Its complete structure and principle of operation are determined and established. Modern graphical interface and data scheme are developed, software is completely realized. Methodology and software correspond to the requirements of the up-to-date designing, describe a general algorithm of program process and also reveals properties of automatic designing system objects. Automatic designing system is based on module principle while using object-orientated programming. Automatic designing system makes it possible to carry out consistently designing calculations of power supply system and select the required equipment with subsequent output of all calculations in the form of explanatory note. Automatic designing system can be applied by designing organizations under conditions of actual designing.

  14. R2-inflation with conformal SM Higgs field

    International Nuclear Information System (INIS)

    We introduce conformal coupling of the Standard Model Higgs field to gravity and discuss the subsequent modification of R2-inflation. The main observation is a lower temperature of reheating which happens mostly through scalaron decays into gluons due to the conformal (trace) anomaly. This modifies all predictions of the original R2-inflation. To the next-to-leading order in slow roll parameters we calculate amplitudes and indices of scalar and tensor perturbations produced at inflation. The results are compared to the next-to-leading order predictions of R2-inflation with minimally coupled Higgs field and of Higgs-inflation. We discuss additional features in gravity wave signal that may help to distinguish the proposed variant of R2-inflation. Remarkably, the features are expected in the region available for study at future experiments like BBO and DECIGO. Finally, we check that (meta)stability of electroweak vacuum in the cosmological model is consistent with recent results of searches for the Higgs boson at LHC

  15. Automatic and controlled processing and the Broad Autism Phenotype.

    Science.gov (United States)

    Camodeca, Amy; Voelker, Sylvia

    2016-01-30

    Research related to verbal fluency in the Broad Autism Phenotype (BAP) is limited and dated, but generally suggests intact abilities in the context of weaknesses in other areas of executive function (Hughes et al., 1999; Wong et al., 2006; Delorme et al., 2007). Controlled processing, the generation of search strategies after initial, automated responses are exhausted (Spat, 2013), has yet to be investigated in the BAP, and may be evidenced in verbal fluency tasks. One hundred twenty-nine participants completed the Delis-Kaplan Executive Function System Verbal Fluency test (D-KEFS; Delis et al., 2001) and the Broad Autism Phenotype Questionnaire (BAPQ; Hurley et al., 2007). The BAP group (n=53) produced significantly fewer total words during the 2nd 15" interval compared to the Non-BAP (n=76) group. Partial correlations indicated similar relations between verbal fluency variables for each group. Regression analyses predicting 2nd 15" interval scores suggested differentiation between controlled and automatic processing skills in both groups. Results suggest adequate automatic processing, but slowed development of controlled processing strategies in the BAP, and provide evidence for similar underlying cognitive constructs for both groups. Controlled processing was predictive of Block Design score for Non-BAP participants, and was predictive of Pragmatic Language score on the BAPQ for BAP participants. These results are similar to past research related to strengths and weaknesses in the BAP, respectively, and suggest that controlled processing strategy use may be required in instances of weak lower-level skills. PMID:26652842

  16. Quantum Hall transitions: An exact theory based on conformal restriction

    Science.gov (United States)

    Bettelheim, E.; Gruzberg, I. A.; Ludwig, A. W. W.

    2012-10-01

    We revisit the problem of the plateau transition in the integer quantum Hall effect. Here we develop an analytical approach for this transition, and for other two-dimensional disordered systems, based on the theory of “conformal restriction.” This is a mathematical theory that was recently developed within the context of the Schramm-Loewner evolution which describes the “stochastic geometry” of fractal curves and other stochastic geometrical fractal objects in two-dimensional space. Observables elucidating the connection with the plateau transition include the so-called point-contact conductances (PCCs) between points on the boundary of the sample, described within the language of the Chalker-Coddington network model for the transition. We show that the disorder-averaged PCCs are characterized by a classical probability distribution for certain geometric objects in the plane (which we call pictures), occurring with positive statistical weights, that satisfy the crucial so-called restriction property with respect to changes in the shape of the sample with absorbing boundaries; physically, these are boundaries connected to ideal leads. At the transition point, these geometrical objects (pictures) become fractals. Upon combining this restriction property with the expected conformal invariance at the transition point, we employ the mathematical theory of “conformal restriction measures” to relate the disorder-averaged PCCs to correlation functions of (Virasoro) primary operators in a conformal field theory (of central charge c=0). We show how this can be used to calculate these functions in a number of geometries with various boundary conditions. Since our results employ only the conformal restriction property, they are equally applicable to a number of other critical disordered electronic systems in two spatial dimensions, including for example the spin quantum Hall effect, the thermal metal phase in symmetry class D, and classical diffusion in two

  17. A complete, multi-level conformational clustering of antibody complementarity-determining regions

    Directory of Open Access Journals (Sweden)

    Dimitris Nikoloudis

    2014-07-01

    Full Text Available Classification of antibody complementarity-determining region (CDR conformations is an important step that drives antibody modelling and engineering, prediction from sequence, directed mutagenesis and induced-fit studies, and allows inferences on sequence-to-structure relations. Most of the previous work performed conformational clustering on a reduced set of structures or after application of various structure pre-filtering criteria. In this study, it was judged that a clustering of every available CDR conformation would produce a complete and redundant repertoire, increase the number of sequence examples and allow better decisions on structure validity in the future. In order to cope with the potential increase in data noise, a first-level statistical clustering was performed using structure superposition Root-Mean-Square Deviation (RMSD as a distance-criterion, coupled with second- and third-level clustering that employed Ramachandran regions for a deeper qualitative classification. The classification of a total of 12,712 CDR conformations is thus presented, along with rich annotation and cluster descriptions, and the results are compared to previous major studies. The present repertoire has procured an improved image of our current CDR Knowledge-Base, with a novel nesting of conformational sensitivity and specificity that can serve as a systematic framework for improved prediction from sequence as well as a number of future studies that would aid in knowledge-based antibody engineering such as humanisation.

  18. 47 CFR 68.320 - Supplier's Declaration of Conformity.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 3 2010-10-01 2010-10-01 false Supplier's Declaration of Conformity. 68.320... Approval § 68.320 Supplier's Declaration of Conformity. (a) Supplier's Declaration of Conformity is a... Supplier's Declaration of Conformity attaches to all items subsequently marketed by the responsible...

  19. Warped products and conformal boundaries of CAT(0)-Spaces

    DEFF Research Database (Denmark)

    Buckley, S.M.; Kokkendorff, Simon Lyngby

    2008-01-01

    We discuss the conformal boundary of a warped product of two length spaces and provide a method to calculate this in terms of the individual conformal boundaries. This technique is then applied to produce CAT(0)-spaces with complicated conformal boundaries. Finally, we prove that the conformal...

  20. 40 CFR 91.106 - Certificate of conformity.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Certificate of conformity. 91.106... Provisions § 91.106 Certificate of conformity. (a) Every manufacturer of a new marine SI engine produced... obtain a certificate of conformity covering each engine family. The certificate of conformity must...

  1. 21 CFR 26.70 - Conformity assessment bodies.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 1 2010-04-01 2010-04-01 false Conformity assessment bodies. 26.70 Section 26.70...Frameworkâ Provisions § 26.70 Conformity assessment bodies. Each party recognizes that the conformity... conformity in relation to its requirements as specified in subpart B of this part. The parties shall...

  2. 47 CFR 2.906 - Declaration of Conformity.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false Declaration of Conformity. 2.906 Section 2.906... Conformity. (a) A Declaration of Conformity is a procedure where the responsible party, as defined in § 2.909... of Conformity attaches to all items subsequently marketed by the responsible party which...

  3. Scanner OPC signatures: automatic vendor-to-vendor OPE matching

    Science.gov (United States)

    Renwick, Stephen P.

    2009-03-01

    As 193nm lithography continues to be stretched and the k1 factor decreases, optical proximity correction (OPC) has become a vital part of the lithographer's tool kit. Unfortunately, as is now well known, the design variations of lithographic scanners from different vendors cause them to have slightly different optical-proximity effect (OPE) behavior, meaning that they print features through pitch in distinct ways. This in turn means that their response to OPC is not the same, and that an OPC solution designed for a scanner from Company 1 may or may not work properly on a scanner from Company 2. Since OPC is not inexpensive, that causes trouble for chipmakers using more than one brand of scanner. Clearly a scanner-matching procedure is needed to meet this challenge. Previously, automatic matching has only been reported for scanners of different tool generations from the same manufacturer. In contrast, scanners from different companies have been matched using expert tuning and adjustment techniques, frequently requiring laborious test exposures. Automatic matching between scanners from Company 1 and Company 2 has remained an unsettled problem. We have recently solved this problem and introduce a novel method to perform the automatic matching. The success in meeting this challenge required three enabling factors. First, we recognized the strongest drivers of OPE mismatch and are thereby able to reduce the information needed about a tool from another supplier to that information readily available from all modern scanners. Second, we developed a means of reliably identifying the scanners' optical signatures, minimizing dependence on process parameters that can cloud the issue. Third, we carefully employed standard statistical techniques, checking for robustness of the algorithms used and maximizing efficiency. The result is an automatic software system that can predict an OPC matching solution for scanners from different suppliers without requiring expert intervention.

  4. The Conformal Version of Black Hole Thermodynamics

    CERN Document Server

    Wu, S Q

    2004-01-01

    The conformal thermodynamics of rotating charged black holes in general relativity and string theory is proposed by considering the first laws of thermodynamics for a pair of systems made up of the two horizons of a Kerr-Newman or Kerr-Sen black hole. These two systems are constructed by only demanding their ``horizon areas'' to be the sum and difference of that of the outer and inner horizons of their prototype. The thermodynamics present here is a ``conformal version'' of black hole thermodynamics, since it is closely related to the near-horizon conformal symmetry of black holes. The concept of non-quasinormal modes recently proposed by D. Birmingham and S. Carlip [7] is compatible with this ``conformal thermodynamics'', rather than the usual ``horizon thermodynamics''. In addition, we show that this conformal thermodynamics resembles to the thermodynamics of effective string or D-brane models, since the two newly-constructed systems bear a striking resemblance to the right- and left-movers in string theory...

  5. Seed Conformal Blocks in 4D CFT

    CERN Document Server

    Echeverri, Alejandro Castedo; Karateev, Denis; Serone, Marco

    2016-01-01

    We compute in closed analytical form the minimal set of "seed" conformal blocks associated to the exchange of generic mixed symmetry spinor/tensor operators in an arbitrary representation (l,\\bar l) of the Lorentz group in four dimensional conformal field theories. These blocks arise from 4-point functions involving two scalars, one (0,|l-\\bar l|) and one (|l-\\bar l|,0) spinors or tensors. We directly solve the set of Casimir equations, that can elegantly be written in a compact form for any (l,\\bar l), by using an educated ansatz and reducing the problem to an algebraic linear system. Various details on the form of the ansatz have been deduced by using the so called shadow formalism. The complexity of the conformal blocks depends on the value of p=|l-\\bar l | and grows with p, in analogy to what happens to scalar conformal blocks in d even space-time dimensions as d increases. These results open the way to bootstrap 4-point functions involving arbitrary spinor/tensor operators in four dimensional conformal f...

  6. Saturating representation of loop conformational fragments in structure databanks

    Directory of Open Access Journals (Sweden)

    Fiser András

    2006-07-01

    Full Text Available Abstract Background Short fragments of proteins are fundamental starting points in various structure prediction applications, such as in fragment based loop modeling methods but also in various full structure build-up procedures. The applicability and performance of these approaches depend on the availability of short fragments in structure databanks. Results We studied the representation of protein loop fragments up to 14 residues in length. All possible query fragments found in sequence databases (Sequence Space were clustered and cross referenced with available structural fragments in Protein Data Bank (Structure Space. We found that the expansion of PDB in the last few years resulted in a dense coverage of loop conformational fragments. For each loops of length 8 in the current Sequence Space there is at least one loop in Structure Space with 50% or higher sequence identity. By correlating sequence and structure clusters of loops we found that a 50% sequence identity generally guarantees structural similarity. These percentages of coverage at 50% sequence cutoff drop to 96, 94, 68, 53, 33 and 13% for loops of length 9, 10, 11, 12, 13, and 14, respectively. There is not a single loop in the current Sequence Space at any length up to 14 residues that is not matched with a conformational segment that shares at least 20% sequence identity. This minimum observed identity is 40% for loops of 12 residues or shorter and is as high as 50% for 10 residue or shorter loops. We also assessed the impact of rapidly growing sequence databanks on the estimated number of new loop conformations and found that while the number of sequentially unique sequence segments increased about six folds during the last five years there are almost no unique conformational segments among these up to 12 residues long fragments. Conclusion The results suggest that fragment based prediction approaches are not limited any more by the completeness of fragments in databanks but

  7. Protein-segment universe exhibiting transitions at intermediate segment length in conformational subspaces

    Directory of Open Access Journals (Sweden)

    Hirokawa Takatsugu

    2008-08-01

    conformational components that were unique to each structural class. Those characteristics suggest that protein segment conformation is described by compositions of the three common structural variables with large contributions and specific structural variables with small contributions. Conclusion The present results of the analyses of four protein structural classes show the universal role of three major components as segment conformational descriptors. The obtained perspectives of distribution changes related to the segment lengths using the three key components suggest both the adequacy and the possibility of further progress on the prediction strategies used in the recent de novo structure-prediction methods.

  8. A reoptimized GROMOS force field for hexopyranose-based carbohydrates accounting for the relative free energies of ring conformers, anomers, epimers, hydroxymethyl rotamers, and glycosidic linkage conformers.

    Science.gov (United States)

    Hansen, Halvor S; Hünenberger, Philippe H

    2011-04-30

    This article presents a reoptimization of the GROMOS 53A6 force field for hexopyranose-based carbohydrates (nearly equivalent to 45A4 for pure carbohydrate systems) into a new version 56A(CARBO) (nearly equivalent to 53A6 for non-carbohydrate systems). This reoptimization was found necessary to repair a number of shortcomings of the 53A6 (45A4) parameter set and to extend the scope of the force field to properties that had not been included previously into the parameterization procedure. The new 56A(CARBO) force field is characterized by: (i) the formulation of systematic build-up rules for the automatic generation of force-field topologies over a large class of compounds including (but not restricted to) unfunctionalized polyhexopyranoses with arbritrary connectivities; (ii) the systematic use of enhanced sampling methods for inclusion of experimental thermodynamic data concerning slow or unphysical processes into the parameterization procedure; and (iii) an extensive validation against available experimental data in solution and, to a limited extent, theoretical (quantum-mechanical) data in the gas phase. At present, the 56A(CARBO) force field is restricted to compounds of the elements C, O, and H presenting single bonds only, no oxygen functions other than alcohol, ether, hemiacetal, or acetal, and no cyclic segments other than six-membered rings (separated by at least one intermediate atom). After calibration, this force field is shown to reproduce well the relative free energies of ring conformers, anomers, epimers, hydroxymethyl rotamers, and glycosidic linkage conformers. As a result, the 56A(CARBO) force field should be suitable for: (i) the characterization of the dynamics of pyranose ring conformational transitions (in simulations on the microsecond timescale); (ii) the investigation of systems where alternative ring conformations become significantly populated; (iii) the investigation of anomerization or epimerization in terms of free-energy differences

  9. The effect of insert conformity and material on total knee replacement wear.

    Science.gov (United States)

    Abdelgaied, Abdellatif; Brockett, Claire L; Liu, Feng; Jennings, Louise M; Jin, Zhongmin; Fisher, John

    2014-01-01

    The mean average life is increasing; therefore, there is a need to increase the lifetime of the prostheses. To fulfil this requirement, new prosthetic designs and materials are being introduced. Two of the design parameters that may affect wear of total knee replacements, and hence the expected lifetime, are the insert conformity and material. Computational models have been used extensively for wear prediction and optimisation of artificial knee designs. The objective of the present study was to use a previously validated non-dimensional wear coefficient-based computational wear model to investigate the effect of insert conformity and material on the predicted wear in total knee replacements. Four different inserts (curved, lipped, partial flat and custom flat), with different conformity levels, were tested against the same femoral and under two different kinematic inputs (intermediate and high), with different levels of cross-shear. The insert bearing materials were either conventional or moderately cross-linked ultra-high molecular weight polyethylene (UHMWPE). Wear predictions were validated against the experimental data from Leeds knee simulation tests. The predicted wear rates for the curved insert (most conformed) were more than three times those for the flat insert (least conformed). In addition, the computationally predicted average volumetric wear rates for moderately cross-linked UHMWPE bearings were less than half of their corresponding conventional UHMWPE bearings. Moreover, the wear of the moderately cross-linked UHMWPE was shown to be less dependent on the degree of cross-shear, compared to conventional UHMWPE. These results along with supporting experimental studies provide insight into the design variables, which may reduce wear in knee replacements.

  10. S-Adenosylmethionine conformations in solution and in protein complexes: Conformational influences of the sulfonium group

    DEFF Research Database (Denmark)

    Markham, George D.; Norrby, Per-Ola; Bock, Charles W.

    2002-01-01

    S-Adenosylmethionine (AdoMet) and other sulfonium ions play central roles in the metabolism of all organisms. The conformational preferences of AdoMet and two other biologically important sulfonium ions, S-methylmethionine and dimethylsulfonioproprionic acid, have been investigated by NMR...... and computational studies. Molecular mechanics parameters for the sulfonium center have been developed for the AMBER force field to permit analysis of NMR results and to enable comparison of the relative energies of the different conformations of AdoMet that have been found in crystal structures of complexes...... with proteins. S-Methylmethionine and S-dimethylsulfonioproprionate adopt a variety of conformations in aqueous solution; a conformation with an electrostatic interaction between the sulfonium sulfur and the carboxylate group is not noticeably favored, in contrast to the preferred conformation found by in vacuo...

  11. The Conformal Method and the Conformal Thin-Sandwich Method Are the Same

    CERN Document Server

    Maxwell, David

    2014-01-01

    The conformal method developed in the 1970s and the more recent Lagrangian and Hamiltonian conformal thin-sandwich methods are techniques for finding solutions of the Einstein constraint equations. We show that they are manifestations of a single conformal method: there is a straightforward way to convert back and forth between the parameters for these methods so that the corresponding solutions of the Einstein constraint equations agree. The unifying idea is the need to clearly distinguish tangent and cotangent vectors to the space of conformal classes on a manifold, and we introduce a vocabulary for working with these objects without reference to a particular representative background metric. As a consequence of these conceptual advantages, we demonstrate how to strengthen previous near-CMC existence and non-existence theorems for the original conformal method to include metrics with scalar curvatures that change sign.

  12. A correspondence between solution-state dynamics of an individual protein and the sequence and conformational diversity of its family.

    Directory of Open Access Journals (Sweden)

    Gregory D Friedland

    2009-05-01

    Full Text Available Conformational ensembles are increasingly recognized as a useful representation to describe fundamental relationships between protein structure, dynamics and function. Here we present an ensemble of ubiquitin in solution that is created by sampling conformational space without experimental information using "Backrub" motions inspired by alternative conformations observed in sub-Angstrom resolution crystal structures. Backrub-generated structures are then selected to produce an ensemble that optimizes agreement with nuclear magnetic resonance (NMR Residual Dipolar Couplings (RDCs. Using this ensemble, we probe two proposed relationships between properties of protein ensembles: (i a link between native-state dynamics and the conformational heterogeneity observed in crystal structures, and (ii a relation between dynamics of an individual protein and the conformational variability explored by its natural family. We show that the Backrub motional mechanism can simultaneously explore protein native-state dynamics measured by RDCs, encompass the conformational variability present in ubiquitin complex structures and facilitate sampling of conformational and sequence variability matching those occurring in the ubiquitin protein family. Our results thus support an overall relation between protein dynamics and conformational changes enabling sequence changes in evolution. More practically, the presented method can be applied to improve protein design predictions by accounting for intrinsic native-state dynamics.

  13. Notes on conformal invariance of gauge fields

    Science.gov (United States)

    Barnich, Glenn; Bekaert, Xavier; Grigoriev, Maxim

    2015-12-01

    In Lagrangian gauge systems, the vector space of global reducibility parameters forms a module under the Lie algebra of symmetries of the action. Since the classification of global reducibility parameters is generically easier than the classification of symmetries of the action, this fact can be used to constrain the latter when knowing the former. We apply this strategy and its generalization for the non-Lagrangian setting to the problem of conformal symmetry of various free higher spin gauge fields. This scheme allows one to show that, in terms of potentials, massless higher spin gauge fields in Minkowski space and partially massless (PM) fields in (A)dS space are not conformal for spin strictly greater than one, while in terms of curvatures, maximal-depth PM fields in four dimensions are also not conformal, unlike the closely related, but less constrained, maximal-depth Fradkin-Tseytlin fields.

  14. Notes on conformal invariance of gauge fields

    CERN Document Server

    Barnich, Glenn; Grigoriev, Maxim

    2015-01-01

    In Lagrangian gauge systems, the vector space of global reducibility parameters forms a module under the Lie algebra of symmetries of the action. Since the classification of global reducibility parameters is generically easier than the classification of symmetries of the action, this fact can be used to constrain the latter when knowing the former. We apply this strategy and its generalization for the non-Lagrangian setting to the problem of conformal symmetry of various free higher spin gauge fields. This scheme allows one to show that, in terms of potentials, massless higher spin gauge fields in Minkowski space and partially-massless fields in (A)dS space are not conformal for spin strictly greater than one, while in terms of curvatures, maximal-depth partially-massless fields in four dimensions are also not conformal, unlike the closely related, but less constrained, maximal-depth Fradkin--Tseytlin fields.

  15. Towards three-dimensional conformal probability

    CERN Document Server

    Abdesselam, Abdelmalek

    2015-01-01

    In this outline of a program, based on rigorous renormalization group theory, we introduce new definitions which allow one to formulate precise mathematical conjectures related to conformal invariance as studied by physicists in the area known as higher-dimensional conformal bootstrap which has developed at a breathtaking pace over the last five years. We also explore a second theme, intimately tied to conformal invariance for random distributions, which can be construed as a search for a very general first and second-quantized Kolmogorov-Chentsov Theorem. First-quantized refers to regularity of sample paths. Second-quantized refers to regularity of generalized functionals or Hida distributions and relates to the operator product expansion. Finally, we present a summary of progress made on a $p$-adic hierarchical model and point out possible connections to number theory.

  16. Lorentzian Einstein metrics with prescribed conformal infinity

    CERN Document Server

    Enciso, Alberto

    2014-01-01

    We prove that there are asymptotically anti-de Sitter Einstein metrics with prescribed conformal infinity. More precisely we show that, given any suitably small perturbation $\\hat g$ of the conformal metric of the $(n+1)$-dimensional anti-de Sitter space at timelike infinity, which is given by the canonical Lorentzian metric on the $n$-dimensional cylinder, there is a Lorentzian Einstein metric on $(-T,T)\\times \\mathbb{B}^n$ whose conformal geometry is given by $\\hat g$. This is a Lorentzian counterpart of the Graham-Lee theorem in Riemannian geometry and is motivated by the holographic prescription problem in the context of the AdS/CFT correspondence in string theory.

  17. SIP Conformance Testing Based on TTCN-2

    Institute of Scientific and Technical Information of China (English)

    LI Tian; WANG Zhiliang; YIN Xia

    2007-01-01

    The session initiation protocol (SIP) is a signaling protocol for Internet telephony, multimedia conferencing, presence, event notification, and instant messaging. With the gaining popularity, more and more SIP implementations have been developed and deployed. How to guarantee the conformance of those SIP implementations is the key point of interconnection and interoperation among them. This paper proposes the test method and architecture for the SIP protocol based on the IPv6 tester system. Tree and tabular combined notation (TTCN-2) is adopted to describe the test suite. With an enhanced reference implementation, the data-processing ability to the original test system has been greatly improved. In the following test practices, some errors have been found in the SIP entities under test. It is proved that the proposed test method and architecture are effective to verify the conformance of the SIP entities, and the result of the conformance test may provide helpful reference to the development of SIP products.

  18. On conformal supergravity and harmonic superspace

    CERN Document Server

    Butter, Daniel

    2015-01-01

    This paper describes a fully covariant approach to harmonic superspace. It is based on the conformal superspace description of conformal supergravity and involves extending the supermanifold M^{4|8} by the tangent bundle of CP^1. The resulting superspace M^{4|8} x TCP^1 can be identified in a certain gauge with the conventional harmonic superspace M^{4|8} x S^2. This approach not only makes the connection to projective superspace transparent, but simplifies calculations in harmonic superspace significantly by eliminating the need to deal directly with supergravity prepotentials. As an application of the covariant approach, we derive from harmonic superspace the full component action for the sigma model of a hyperkahler cone coupled to conformal supergravity. Further applications are also sketched.

  19. Causality constraints in conformal field theory

    Science.gov (United States)

    Hartman, Thomas; Jain, Sachin; Kundu, Sandipan

    2016-05-01

    Causality places nontrivial constraints on QFT in Lorentzian signature, for example fixing the signs of certain terms in the low energy Lagrangian. In d dimensional conformal field theory, we show how such constraints are encoded in crossing symmetry of Euclidean correlators, and derive analogous constraints directly from the conformal bootstrap (analytically). The bootstrap setup is a Lorentzian four-point function corresponding to propagation through a shockwave. Crossing symmetry fixes the signs of certain log terms that appear in the conformal block expansion, which constrains the interactions of low-lying operators. As an application, we use the bootstrap to rederive the well known sign constraint on the (∂ ϕ)4 coupling in effective field theory, from a dual CFT. We also find constraints on theories with higher spin conserved currents. Our analysis is restricted to scalar correlators, but we argue that similar methods should also impose nontrivial constraints on the interactions of spinning operators.

  20. R\\'enyi entropy and conformal defects

    CERN Document Server

    Bianchi, Lorenzo; Myers, Robert C; Smolkin, Michael

    2015-01-01

    We propose a field theoretic framework for calculating the dependence of R\\'enyi entropies on the shape of the entangling surface in a conformal field theory. Our approach rests on regarding the corresponding twist operator as a conformal defect and, in particular, we define the displacement operator which implements small local deformations of the entangling surface. We conjecture a simple relation between the coefficient defining the two-point function of the displacement operator and the conformal weight of the twist operator. With this approach, we are able to consolidate a number of apparently distinct conjectures found in the literature about the R\\'enyi entropy. In particular, we examine a conjecture regarding the universal coefficient associated with a conical singularity in the entangling surface for CFTs in any number of spacetime dimensions. We also provide a general formula for the second order variation of the R\\'enyi entropy arising from small deformations of a spherical entangling surface, exte...