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Sample records for auto exposure control

  1. Clementine auto exposure control software

    Energy Technology Data Exchange (ETDEWEB)

    Arnold, E. [Lawrence Livermore National Lab., CA (United States)

    1994-11-15

    The primary mission of the Clementine program was to test technology developed under the auspices of BMDO (the Ballistic Missile Defense Organization). A secondary goal of the program was to provide astronomical data to the scientific and educational community. The mission plan developed to accomplish these goals included complete mapping of the lunar surface and a close fly-by of a near-Earth asteroid, 1620 Geographos. Exposure control for the Clementine mission was driven by mission phase requirements and sensor characteristics. Thus, there were a total of twelve algorithms developed for three primary mission phases and the four imaging sensors (two additional sensors operated as star trackers). The three mission phases in question were lunar mapping, distant observation of the asteroid for the purpose of tracking, and close-up viewing (as close as 100 Km) of Geographos. The four non-star tracker sensors consisted of an Ultra Violet/Visible (UV/Vis) camera, a High Resolution (HiRes) camera with a built-in LIDAR (Light Detection And Ranging) unit, a Near Infrared (NIR) camera, and a Long Wave InfraRed (LWIR) camera. Due to lack of test time and uncertainties about the imaging environment, numerous input parameters were provided in the algorithms to allow extensive tuning of the exposure control during the mission.

  2. AUTO

    DEFF Research Database (Denmark)

    Gammelgaard Nielsen, Anders; Aagaard, Tine; Diaz, pauline

    2011-01-01

    AUTO is the first assignment that the students of Architecture are introduced to at the Aarhus school of Architecture. The aim is to give students an understanding of design through a generic working method. This by disassembling a car engine and staging its components through a series of castings...

  3. Design of Auto Exposure Unit Based On 2-Way Histogram Equalization

    OpenAIRE

    Junghwan Choi; Seongsoo Lee

    2013-01-01

    Histogram equalization is often used in image enhancement, but it can be also used in auto exposure. However, conventional histogram equalization does not work well when many pixels are concentrated in a narrow luminance range.This paper proposes an auto exposure method based on 2-way histogram equalization. Two cumulative distribution functions are used, where one is from dark to bright and the other is from bright to dark. In this paper, the proposed auto exposure method is also designed an...

  4. AutoCAD electrical 2013 for electrical control designers

    CERN Document Server

    Tickoo, Sham; CADCIM Technologies

    2013-01-01

    The AutoCAD Electrical 2013 for Electrical Control Designers textbook has been written to assist the engineering students and the practicing designers learn the application of various AutoCAD Electrical tools and options for creating electrical control designs. After reading this textbook, the users will be able to create professional electrical-control drawings easily and effectively. Moreover, the users will be able to automate various control engineering tasks such as building circuits, numbering wires, creating bills of materials, and many more. The textbook takes the users across a wide spectrum of electrical control drawings through progressive examples and numerous illustrations and exercises, thereby making it an ideal guide for both the novice and the advanced users. Salient Features of the Textbook Consists of 14 chapters that are organized in a pedagogical sequence covering various tools and features of AutoCAD Electrical such as schematic drawings, parametric and non-parametric PLC modules, Circu...

  5. Assessment of heavy metal exposure around auto body refinishing ...

    African Journals Online (AJOL)

    Significant number of occupations are present in our society which involves metal pollution. These small operational occupations which are always neglected by governments and other occupational health services are another major factor of metal flow in urban soil. The local auto body refinishing shops are one of these ...

  6. Skin symptoms in bakery and auto body shop workers: associations with exposure and respiratory symptoms.

    Science.gov (United States)

    Arrandale, Victoria; Meijster, Tim; Pronk, Anjoeka; Doekes, Gert; Redlich, Carrie A; Holness, D Linn; Heederik, Dick

    2013-02-01

    Despite the importance of skin exposure, studies of skin symptoms in relation to exposure and respiratory symptoms are rare. The goals of this study were to describe exposure-response relationships for skin symptoms, and to investigate associations between skin and respiratory symptoms in bakery and auto body shop workers. Data from previous studies of bakery and auto body shop workers were analyzed. Average exposure estimates for wheat allergen and isocyanates were used. Generalized linear models were constructed to describe the relationships between exposure and skin symptoms, as well as between skin and respiratory symptoms. Data from 723 bakery and 473 auto body shop workers were analyzed. In total, 5.3% of bakery and 6.1% of auto body shop workers were female; subjects' mean age was 39 and 38 years, respectively. Exposure-response relationships were observed in auto body shop workers for itchy or dry skin (PR 1.55, 95% CI 1.2-2.0) and work-related itchy skin (PR 1.97, 95% CI 1.2-3.3). A possible exposure-response relationship for work-related itchy skin in bakery workers did not reach statistical significance. In both groups, reporting skin symptoms was strongly and significantly associated with reporting respiratory symptoms, both work-related and non-work-related. Exposure-response relationships were observed for skin symptoms in auto body shop workers. The lack of significant exposure-response associations in bakery workers should be interpreted cautiously. Workers who reported skin symptoms were up to four times more likely to report respiratory symptoms. Improved awareness of both skin and respiratory outcomes in exposed workers is needed.

  7. AutoCAD electrical 2016 for electrical control designers

    CERN Document Server

    Tickoo, Sham

    2016-01-01

    The AutoCAD Electrical 2016 for Electrical Control Designers textbook has been written to assist the engineering students and the practicing designers who are new to AutoCAD Electrical. Using this textbook, the readers can learn the application of basic tools required for creating professional electrical control drawings with the help of AutoCAD Electrical. Keeping in view the varied requirements of the users, this textbook covers a wide range of tools and features such as schematic drawings, Circuit Builder, panel drawings, parametric and nonparametric PLC modules, stand-alone PLC I/O points, ladder diagrams, point-to-point wiring diagrams, report generation, creation of symbols, and so on. This will help the readers to create electrical drawings easily and effectively. Special emphasis has been laid on the introduction of concepts, which have been explained using text and supported with graphical examples. The examples and tutorials used in this book ensure that the users can relate the information provided...

  8. Auto-control experiments on DIDO using discontinuous feedback

    International Nuclear Information System (INIS)

    Lawrence, L.A.J.

    1959-12-01

    Experiments on auto-controlling the reactor DIDO are described and the equipment design discussed in some detail. The experiments are carried out to show the suitability of an on/off type of control for the maintenance of: (a) a constant flux level in the presence of noise. (b) constant period during power change. The controlling signals stem from measurement of neutron flux computed to give deviation from demanded power, and period respectively. These signals are fed to a D.C. amplifier with variable deadbang whose output is used to control relays, these in turn control the coarse control arms by means of three-phase motors. The system is designed on the basis of locus diagrams, a conventional non-linear technique being used to handle the relay performance. Calculation of the reactor transfer function at high and low power respectively shows that the stability margin is not appreciably affected by the inherent thermodynamic feedback in the reactor core. (author)

  9. Personal exposure control system

    International Nuclear Information System (INIS)

    Tanabe, Ken-ichi; Akashi, Michio

    1994-01-01

    Nuclear power stations are under strict radiation control. Exposure control for nuclear workers is the most important operation, and so carefully thought out measures are taken. This paper introduces Fuji Electric's personal exposure control system that meets strict exposure control and rationalizes control operations. The system has a merit that it can provide required information in an optimum form using the interconnection of a super minicomputer and exposure control facilities and realizes sophisticated exposure control operations. (author)

  10. Fault tolerant control of multivariable processes using auto-tuning PID controller.

    Science.gov (United States)

    Yu, Ding-Li; Chang, T K; Yu, Ding-Wen

    2005-02-01

    Fault tolerant control of dynamic processes is investigated in this paper using an auto-tuning PID controller. A fault tolerant control scheme is proposed composing an auto-tuning PID controller based on an adaptive neural network model. The model is trained online using the extended Kalman filter (EKF) algorithm to learn system post-fault dynamics. Based on this model, the PID controller adjusts its parameters to compensate the effects of the faults, so that the control performance is recovered from degradation. The auto-tuning algorithm for the PID controller is derived with the Lyapunov method and therefore, the model predicted tracking error is guaranteed to converge asymptotically. The method is applied to a simulated two-input two-output continuous stirred tank reactor (CSTR) with various faults, which demonstrate the applicability of the developed scheme to industrial processes.

  11. Automatic detection of AutoPEEP during controlled mechanical ventilation

    Directory of Open Access Journals (Sweden)

    Nguyen Quang-Thang

    2012-06-01

    Full Text Available Abstract Background Dynamic hyperinflation, hereafter called AutoPEEP (auto-positive end expiratory pressure with some slight language abuse, is a frequent deleterious phenomenon in patients undergoing mechanical ventilation. Although not readily quantifiable, AutoPEEP can be recognized on the expiratory portion of the flow waveform. If expiratory flow does not return to zero before the next inspiration, AutoPEEP is present. This simple detection however requires the eye of an expert clinician at the patient’s bedside. An automatic detection of AutoPEEP should be helpful to optimize care. Methods In this paper, a platform for automatic detection of AutoPEEP based on the flow signal available on most of recent mechanical ventilators is introduced. The detection algorithms are developed on the basis of robust non-parametric hypothesis testings that require no prior information on the signal distribution. In particular, two detectors are proposed: one is based on SNT (Signal Norm Testing and the other is an extension of SNT in the sequential framework. The performance assessment was carried out on a respiratory system analog and ex-vivo on various retrospectively acquired patient curves. Results The experiment results have shown that the proposed algorithm provides relevant AutoPEEP detection on both simulated and real data. The analysis of clinical data has shown that the proposed detectors can be used to automatically detect AutoPEEP with an accuracy of 93% and a recall (sensitivity of 90%. Conclusions The proposed platform provides an automatic early detection of AutoPEEP. Such functionality can be integrated in the currently used mechanical ventilator for continuous monitoring of the patient-ventilator interface and, therefore, alleviate the clinician task.

  12. Comprehensive Auto CAD

    International Nuclear Information System (INIS)

    Jang, Taekju

    1993-06-01

    This book starts introduction of conception, application system, software for CAD, function of Auto CAD, kinds and function of Auto CAD files. It deals with starting of Auto CAD, dialogue box and Auto CAD interface, utility command, 2D drawing command, check command, control system, dimension, hatching command, layer command, block, 3D drawing, plotting and printing, auto CAD and application of data, supply program of auto CAD, AME and region modeler, EDLIN, script optimization of Auto CAD and composition on demand.

  13. Design of auto-control high-voltage control system of pulsed neutron generator

    International Nuclear Information System (INIS)

    Lv Juntao

    2008-01-01

    It is difficult to produce multiple anode controlling time sequences under different logging mode for the high-voltage control system of the conventional pulsed neutron generator. It is also difficult realize sequential control among anode high-voltage, filament power supply and target voltage to make neutron yield stable. To these problems, an auto-control high-voltage system of neutron pulsed generator was designed. It not only can achieve anode high-voltage double blast time sequences, which can measure multiple neutron blast time sequences such as Σ, activated spectrum, etc. under inelastic scattering mode, but also can realize neutron generator real-time measurement of multi-state parameters and auto-control such as target voltage pulse width modulation (PWM), filament current, anode current, etc., there by it can produce stable neutron yield and realize stable and accurate measurement of the pulsed neutron full spectral loging tool. (authors)

  14. An Auto Tuning Substation Peak Shaving Controller for Congestion Management Using Flexible Demand

    DEFF Research Database (Denmark)

    Sossan, Fabrizio; Marinelli, Mattia

    2013-01-01

    A closed loop substation peak shaving/congestion management controller for radial distribution networks is presented. The controller it uses an individual control signal in order to shift the consumption of a population of demand side resources, DSRs. The controller auto tunes its parameters on...

  15. Auto-ignition control in turbocharged internal combustion engines operating with gaseous fuels

    International Nuclear Information System (INIS)

    Duarte, Jorge; Amador, Germán; Garcia, Jesus; Fontalvo, Armando; Vasquez Padilla, Ricardo; Sanjuan, Marco; Gonzalez Quiroga, Arturo

    2014-01-01

    Control strategies for auto-ignition control in turbocharged internal combustion engines operating with gaseous fuels are presented. Ambient temperature and ambient pressure are considered as the disturbing variables. A thermodynamic model for predicting temperature at the ignition point is developed, adjusted and validated with a large experimental data-set from high power turbocharged engines. Based on this model, the performance of feedback and feedforward auto-ignition control strategies is explored. A robustness and fragility analysis for the Feedback control strategies is presented. The feedforward control strategy showed the best performance however its implementation entails adding a sensor and new control logic. The proposed control strategies and the proposed thermodynamic model are useful tools for increasing the range of application of gaseous fuels with low methane number while ensuring a safe running in internal combustion engines. - Highlights: • A model for predicting temperature at the ignition point. • Robust PID, modified PID, and feedforward strategies for auto-ignition control. • λ′ were the best set of tuning equations for calculating controller parameters. • Robust PID showed significant improvements in auto-ignition control. • Feedforward control showed the best performance

  16. [Value of positive auto controls in the gel centrifugation method].

    Science.gov (United States)

    Eichler, H; Kretschmer, V

    1994-01-01

    We studied 97 samples of patients being positive in the autocontrol of the indirect antiglobulin test (IAT) in the gel system (DiaMed). In 83.2%, retesting with monospecific anti-IgG serum gave also positive results, due to a specific phenomenon caused, for example, by drug-specific antibodies (AB), warm auto-AB or allo-AB. In contrast, only 52.9% of the samples retested by the standard tube technique with polyspecific antiglobulin serum reacted positive. Only in 6 patients slightly increased cold agglutinins could be detected. None of the investigated patients showed any clinical or laboratory signs of hemolysis except one with pernicious anemia. We conclude that positive results of the autocontrol in the gel IAT should be confirmed by an additional DAT in the tube technique. If this second test shows a negative result, transfusions can take place without any restrictions.

  17. DESIGN AND DEVELOPMENT OF AUTO DEPTH CONTROL OF REMOTELY OPERATED VEHICLE USING THRUSTER SYSTEM

    Directory of Open Access Journals (Sweden)

    F.A. Ali

    2014-12-01

    Full Text Available Remotely Operated Vehicles are underwater robots designed specifically for surveillance, monitoring and collecting data for underwater activities. In the underwater vehicle industries, the thruster is an important part in controlling the direction, depth and speed of the ROV. However, there are some ROVs that cannot be maintained at the specified depth for a long time because of disturbance. This paper proposes an auto depth control using a thruster system. A prototype of a thruster with an auto depth control is developed and attached to the previously fabricated UTeM ROV. This paper presents the operation of auto depth control as well as thrusters for submerging and emerging purposes and maintaining the specified depth. The thruster system utilizes a microcontroller as its brain, a piezoresistive strain gauge pressure sensor and a DC brushless motor to run the propeller. Performance analysis of the auto depth control system is conducted to identify the sensitivity of the pressure sensor, and the accuracy and stability of the system. The results show that the thruster system performs well in maintaining a specified depth as well as stabilizing itself when a disturbanceoccurs even with a simple proportional controller used to control the thruster, where the thruster is an important component of the ROV.

  18. Patient and staff exposure to glutaraldehyde from KeyMed Auto-Disinfector endoscope washing machine.

    Science.gov (United States)

    Lynch, D A; Parnell, P; Porter, C; Axon, A T

    1994-05-01

    Activated glutaraldehyde (2%) is the recommended agent for disinfection of endoscopic equipment. Exposure to the disinfectant is associated with side-effects and guidelines have been set to avoid these complications. Endoscope washing machines are used to provide automated high level disinfection of endoscopes as well as reduce exposure to the irritant aldehyde. We report a design fault in an endoscope washing machine which results in patients and staff being exposed to activated glutaraldehyde. The Auto-Disinfector (KeyMed) comprises a washing chamber supplied by three separate reservoirs (detergent, disinfectant, and rinse water) via a common channel. After the first cycle endoscopes are processed using previously used detergent and rinse water. Rinse water glutaraldehyde concentrations were measured in four machines during routine endoscopy lists on at least two occasions and showed a progressive rise in glutaraldehyde concentration up to 0.1% after two to six cycles. This results in staff being exposed to glutaraldehyde present on the processed instrument and the disinfectant being pumped from the internal channels of the endoscope into direct contact with the gastrointestinal mucosa during endoscopy at concentrations of 200-1000 ppm. The present atmospheric limit for glutaraldehyde is 0.2 ppm. Skin and mucosal irritation occur at concentrations of 0.3 ppm and severe synovitis in experimental animals at 100 pm. Tongue swelling and bloody diarrhoea with characteristic mucosal histological changes have been reported in patients exposed to activated glutaraldehyde on inadequately rinsed equipment. To reduce this problem the rinse water should be changed after every cycle and the endoscope should be dried thoroughly before use.

  19. Benzene exposure among auto-repair workers from workplace ambience: a pioneer study from Pakistan.

    Science.gov (United States)

    Kamal, Atif; Rashid, Audil

    2014-10-01

    In Pakistan, the reports on benzene exposure among workers in chemical industries are almost non-existing due to limited research work in the field of exposure science. This study aimed to investigate such exposure in a widely adopted occupation in Rawalpindi city. In this cross-sectional study, 60 blood samples (N = 20/group) of mechanics (MCs), spray painters (PNs) and control participants (CN) were analyzed. The socio-economic and demographic information of workers and that of workplaces was documented using a short questionnaire. We identified that the workers in spray-painting occupation are highly at risk of benzene exposure. The results showed that PNs were more at risk of exposure to benzene than MCs, and this exposure was significantly correlated with long working hours (r = 0.68, p chemicals, other identified predictors of exposure included active and passive smoking, poor workplace hygiene and substandard ventilation. To mitigate workplace exposure, it is necessary to reduce working hours and encourage regular use of self-protective equipments and adoption of proper hygiene in chemical workplaces.

  20. Fuzzy Auto-adjust PID Controller Design of Brushless DC Motor

    Science.gov (United States)

    Yuanxi, Wang; Yali, Yu; Guosheng, Zhang; Xiaoliang, Sheng

    Using conventional PID control method, to guarantee the rapidity and small overshoot dynamic and static performance of the BLDCM (brushless DC motor) system is out of the question. The control method to combine fuzzy control with PID control was fit the multivariable strong coupling nonlinear characteristic of BLDCM system. Matlab/Simulink simulation model had been built. The result of computer simulation shows that, compared with the conventional PID controller, the dynamic and static performance of fuzzy auto-adjust PID controller are put forward to optimize. The research work of this paper has profound significance for high precision controller design.

  1. Model Development for Auto Spare Parts Inventory Control and ...

    African Journals Online (AJOL)

    The immense dynamics and criticality of spare parts and the large revenues accrued, as essential motivating factors for providing control in manufacturing companies has never showed any sign of decrease. In fact, in the vast technological environment of today the complexities of Spare Parts Inventory Control enjoys more ...

  2. PID controller auto-tuning based on process step response and damping optimum criterion.

    Science.gov (United States)

    Pavković, Danijel; Polak, Siniša; Zorc, Davor

    2014-01-01

    This paper presents a novel method of PID controller tuning suitable for higher-order aperiodic processes and aimed at step response-based auto-tuning applications. The PID controller tuning is based on the identification of so-called n-th order lag (PTn) process model and application of damping optimum criterion, thus facilitating straightforward algebraic rules for the adjustment of both the closed-loop response speed and damping. The PTn model identification is based on the process step response, wherein the PTn model parameters are evaluated in a novel manner from the process step response equivalent dead-time and lag time constant. The effectiveness of the proposed PTn model parameter estimation procedure and the related damping optimum-based PID controller auto-tuning have been verified by means of extensive computer simulations. © 2013 ISA. Published by Elsevier Ltd. All rights reserved.

  3. Closed loop auto control system software for Miniature Neutron Source Reactors (MNSRs)

    International Nuclear Information System (INIS)

    Iqbal, Masood; Qadir, Javed

    2009-01-01

    A closed loop auto control system has been developed and implemented at the Pakistan Research Reactor-2 (PARR-2). For interfacing of the site signals with a computer, a data acquisition card was employed. The system utilizes nine signals and, on their basis, carries out continuous on-line analysis, maintaining safe operation. On-line reactivity measurement is included in this software. Also, it generates control signals for keeping the reactor at the desired power level in auto-mode round-the-clock without human intervention. In case of abnormal conditions for either power or temperature or radiation level, alarms are initiated and if their levels reach beyond prescribed safe operation regime, automatic shutdown sequence is initiated. The control system has been thoroughly tested for various postulated scenarios. The test results have been in good agreement with the expected response. (orig.)

  4. The Signal Detection and Control Circuit Design for Confocal Auto-Focus System

    Directory of Open Access Journals (Sweden)

    Yin Liu

    2016-01-01

    Full Text Available Based on the demands of Confocal Auto-Focus system, the implementation method of signal measurement circuit and control circuit is given. Using the high performance instrumental amplifier AD620BN, low noise precision FET Op amplifier AD795JRZ and ultralow offset voltage Op amplifier OP07EP, a signal measurement circuit used to converse the two differential light intensity signal to electric signal is designed. And a control circuit which takes MCU MSP430F149 as core processes the former signal and generate a control signal driving the platform for auto-focusing. The experimental results proved the feasibility and correctness of circuits. And the system meets the design requirement.

  5. Auto Code Generation for Simulink-Based Attitude Determination Control System

    Science.gov (United States)

    MolinaFraticelli, Jose Carlos

    2012-01-01

    This paper details the work done to auto generate C code from a Simulink-Based Attitude Determination Control System (ADCS) to be used in target platforms. NASA Marshall Engineers have developed an ADCS Simulink simulation to be used as a component for the flight software of a satellite. This generated code can be used for carrying out Hardware in the loop testing of components for a satellite in a convenient manner with easily tunable parameters. Due to the nature of the embedded hardware components such as microcontrollers, this simulation code cannot be used directly, as it is, on the target platform and must first be converted into C code; this process is known as auto code generation. In order to generate C code from this simulation; it must be modified to follow specific standards set in place by the auto code generation process. Some of these modifications include changing certain simulation models into their atomic representations which can bring new complications into the simulation. The execution order of these models can change based on these modifications. Great care must be taken in order to maintain a working simulation that can also be used for auto code generation. After modifying the ADCS simulation for the auto code generation process, it is shown that the difference between the output data of the former and that of the latter is between acceptable bounds. Thus, it can be said that the process is a success since all the output requirements are met. Based on these results, it can be argued that this generated C code can be effectively used by any desired platform as long as it follows the specific memory requirements established in the Simulink Model.

  6. Study of exposure to cold stress and body physiological responses in auto mechanic employees in Hamadan city

    Directory of Open Access Journals (Sweden)

    Keivan Saedpanah

    2017-09-01

    Full Text Available Introduction: Continuous exposure to cold air is considered to be a hazardous agent in the workplace in cold seasons. This study aimed to determine the level of cold stress and relation with physiological responses in auto mechanic employees. Method: This cross-sectional study was conducted in the winter of 1395 on auto mechanic employees in Hamadan city. Physiological responses during daily activity were measured in accordance with ISO 9886 standard method. Environmental air measures like air temperature and air velocity were measured simultaneously and cold stress indexes were also determined. Data was analyzed using SPSS 21 software. Result: The result showed that mean wind chill index, equivalent chill temperature and required clothing insulation were 489.97±47.679 kcal/m2.h, 13.78± 1.869 0c and 2.04 ± 0.246 clo, respectively. According to the results of cold stress indexes, the studied employees are exposed to cold stress. Pearson correlation test showed that there are significant relationship between cold stress indexes with physiological responses (p<0.05, however, IREQ min showed more correlation than the others.  There is also a significant relationship between body fat percentage and deep temperature (p<0.05, r=0.314. Conclusion: The result confirmed that IREQ min index has high validity for estimation of cold stress among auto mechanic employees. Moreover, the increase of body fat percentage leads to an increase of cold tolerance power of employees.

  7. Computer auto-feedback control system for plasma displacement on HL-1M

    International Nuclear Information System (INIS)

    Bu Mingnan; Deng Hongying; Liu Yanping; Liu Yuqin; Liu Xuemei

    1998-12-01

    Plasma displacement control plays an important role in the experiments on HL-1M. It is significant to study how to improve the operation condition, stability and reliability of the control system, and to satisfy the operation requirement of HL-1M, because the operation condition will directly affect the discharge quality and the final result of different experiment. The computer auto-feedback control system for plasma displacement control is presented. By using the computer and the high accurate electronic component the great amelioration has been made on plasma displacement control, discharge quality and efficiency

  8. A Development of Auto Calibration Analog Input Module for Safety-related Controller

    International Nuclear Information System (INIS)

    Yoo, Kwan Woo; Yun, Dong Hwa; Hwang, Sung Jae; Lee, Dong Il

    2014-01-01

    The purpose of this paper is to provide the auto calibration analog input module design of POSAFE-Q is a PLC(Programmable Logic Controller) that has been developed for the evaluation of safety-related. Analog input module from the control equipment of the safety-related, has a very significant proportion. Analog input module is a device that converts digital data that can be that the processor module recognizes the analog signals from the pressure device in the field, the flow rate, and temperature. In this paper, to check the Auto Calibration function of the RTD (Resistance Temperature Detector) input module. In order to ensure the accuracy of the analog input module, calibration function is required, it is necessary to ensure the accuracy of ±0.1% (1% in the standard PT100 sensor)

  9. Distributed Fair Auto Rate Medium Access Control for IEEE 802.11 Based WLANs

    Science.gov (United States)

    Zhu, Yanfeng; Niu, Zhisheng

    Much research has shown that a carefully designed auto rate medium access control can utilize the underlying physical multi-rate capability to exploit the time-variation of the channel. In this paper, we develop a simple analytical model to elucidate the rule that maximizes the throughput of RTS/CTS based multi-rate wireless local area networks. Based on the discovered rule, we propose two distributed fair auto rate medium access control schemes called FARM and FARM+ from the view-point of throughput fairness and time-share fairness, respectively. With the proposed schemes, after receiving a RTS frame, the receiver selectively returns the CTS frame to inform the transmitter the maximum feasible rate probed by the signal-to-noise ratio of the received RTS frame. The key feature of the proposed schemes is that they are capable of maintaining throughput/time-share fairness in asymmetric situation where the distribution of SNR varies with stations. Extensive simulation results show that the proposed schemes outperform the existing throughput/time-share fair auto rate schemes in time-varying channel conditions.

  10. Radiation camera exposure control

    International Nuclear Information System (INIS)

    Martone, R.J.; Yarsawich, M.; Wolczek, W.

    1976-01-01

    A system and method for governing the exposure of an image generated by a radiation camera to an image sensing camera is disclosed. The exposure is terminated in response to the accumulation of a predetermined quantity of radiation, defining a radiation density, occurring in a predetermined area. An index is produced which represents the value of that quantity of radiation whose accumulation causes the exposure termination. The value of the predetermined radiation quantity represented by the index is sensed so that the radiation camera image intensity can be calibrated to compensate for changes in exposure amounts due to desired variations in radiation density of the exposure, to maintain the detectability of the image by the image sensing camera notwithstanding such variations. Provision is also made for calibrating the image intensity in accordance with the sensitivity of the image sensing camera, and for locating the index for maintaining its detectability and causing the proper centering of the radiation camera image

  11. Computer-controlled system for plasma ion energy auto-analyzer

    International Nuclear Information System (INIS)

    Wu Xianqiu; Chen Junfang; Jiang Zhenmei; Zhong Qinghua; Xiong Yuying; Wu Kaihua

    2003-01-01

    A computer-controlled system for plasma ion energy auto-analyzer was technically studied for rapid and online measurement of plasma ion energy distribution. The system intelligently controls all the equipments via a RS-232 port, a printer port and a home-built circuit. The software designed by LabVIEW G language automatically fulfils all of the tasks such as system initializing, adjustment of scanning-voltage, measurement of weak-current, data processing, graphic export, etc. By using the system, a few minutes are taken to acquire the whole ion energy distribution, which rapidly provide important parameters of plasma process techniques based on semiconductor devices and microelectronics

  12. Skin exposure to aliphatic polyisocyanates in the auto body repair and refinishing industry: II. A quantitative assessment.

    Science.gov (United States)

    Bello, Dhimiter; Redlich, Carrie A; Stowe, Meredith H; Sparer, Judy; Woskie, Susan R; Streicher, Robert P; Hosgood, H Dean; Liu, Youcheng

    2008-03-01

    Skin exposure to isocyanates, in addition to respiratory exposures, may contribute to sensitization and asthma. Quantitative skin exposure data are scarce and quantitative methods limited. As part of the Survey of Painters and Repairers of Autobodies by Yale study, a method to sample and quantify human isocyanate skin exposure was developed (based on NIOSH 5525 method) and used to evaluate aliphatic isocyanate skin exposure in 81 auto body shop painters and body technicians. Wipe samples were collected from unprotected skin and from under PPE (gloves, clothing and respirator) using a polypropylene glycol-impregnated wipe. Hexamethylene diisocyanate (HDI), its polyisocyanates [HDI-derived polyisocyanates (pHDI)], isophorone diisocyanate (IPDI) and its polyisocyanates and IPDI-derived polyisocyanates (pIPDI) were quantified separately and also expressed as the total free isocyanate groups (total NCO). For unprotected skin areas, 49 samples were collected for spray painting, 13 for mixing, 27 for paint-related tasks (e.g. sanding and compounding) and 53 for non-paint-related tasks. Forty-three samples were also collected under PPE. The geometric mean (GM) [geometric standard deviation (GSD)] total NCO concentrations (ng NCO cm(-2)) for unprotected skin (hands, face and forearms) was 1.9 (10.9) and range 0.0-64.4. pHDI species were the major contributor to the total NCO content. Levels were very variable, with the highest concentrations measured for clear coating and paint mixing tasks. Isocyanate skin exposure was also commonly detected under PPE, with 92% of samples above the limit of detection. Levels were very variable with the overall GM (GSD) total NCO (ng NCO cm(-2)) under PPE 1.0 (5.2) and range (0.0-47.0) and similar under the different PPE (glove, respirator and clothing). The highest concentrations were detected for mixing and spraying tasks, 6.9 (5.3) and 1.0 (5.2), respectively. Levels under PPE were generally lower than unpaired samples obtained with no

  13. Auto-optimized fuzzy control of car engines based on GA

    Science.gov (United States)

    Chen, Yu-guang; Zhang, Zhi-yuan; Liao, Shi-li; Chen, Xin-gang

    2005-12-01

    Because the parameters of car-engines are of the discreteness, nonlinear and uncertain characteristics, a conventional control model can not accurately control the excess air coefficient and the spark advance angle in dynamic procedures. A new auto-optimized fuzzy control model based on genetic arithmetic was introduced. The controller design scheme based on using an embedded operating system to achieve such a control model was discussed. Based on a real-time simulation, using GA resulted in the fuzzy control parameters being optimized automatically. The results of experiments showed that the dynamic indexes and the fuel economy indexes can be improved greatly. The model has the obvious advantage of reducing fuel consumption.

  14. An auto-bias control scheme for IQ-modulator with various modulation formats

    Science.gov (United States)

    Zhang, Wenqi; Yuan, Xueguang; Zhang, Yang'an

    2016-10-01

    We propose and demonstrate an auto-bias control scheme for the IQ-modulator of a flexible optical PSK or QAM or other modulation formats transmitter in this paper. Due to IQ-modulators usually producing higher-order modulation format, these modulation formats involve phase mostly. It is based on that the bias drift will change the operating point and result in varying the output optical phase. This technology has no restrictions on modulation formats, so it has good flexibility. The experimental result show the three biases can be stabilized when the proposed scheme is implemented.

  15. Skin symptoms in bakery and auto body shop workers: Associations with exposure and respiratory symptoms

    NARCIS (Netherlands)

    Arrandale, V.; Meijster, T.; Pronk, A.; Doekes, G.; Redlich, C.A.; Holness, D.L.; Heederik, D.

    2013-01-01

    Purpose: Despite the importance of skin exposure, studies of skin symptoms in relation to exposure and respiratory symptoms are rare. The goals of this study were to describe exposure-response relationships for skin symptoms, and to investigate associations between skin and respiratory symptoms in

  16. Auto-tuning of PID controller parameters with supervised receding horizon optimization.

    Science.gov (United States)

    Xu, Min; Li, Shaoyuan; Qi, Chenkun; Cai, Wenjian

    2005-10-01

    In this paper, a novel two-layer online auto-tuning algorithm is presented for a nonlinear time-varying system. The lower layer consists of a conventional proportional-integral-derivative (PID) controller and a plant process, while the upper layer is composed of identification and tuning modules. The purpose of the upper layer is to find a set of optimal PID parameters for the lower layer via an online receding horizon optimization approach, which result in a time-varying PID controller. Through mathematical analysis, the proposed system performance is equivalent to that of a standard generalized predictive control. Simulation and experiment demonstrate that the new method has a better control system performance compared with conventional PID controllers.

  17. Effects of Mixture Stratification on Combustion and Emissions of Boosted Controlled Auto-Ignition Engines

    Directory of Open Access Journals (Sweden)

    Jacek Hunicz

    2017-12-01

    Full Text Available The stratification of in-cylinder mixtures appears to be an effective method for managing the combustion process in controlled auto-ignition (CAI engines. Stratification can be achieved and controlled using various injection strategies such as split fuel injection and the introduction of a portion of fuel directly before the start of combustion. This study investigates the effect of injection timing and the amount of fuel injected for stratification on the combustion and emissions in CAI engine. The experimental research was performed on a single cylinder engine with direct gasoline injection. CAI combustion was achieved using negative valve overlap and exhaust gas trapping. The experiments were performed at constant engine fueling. Intake boost was applied to control the excess air ratio. The results show that the application of the late injection strategy has a significant effect on the heat release process. In general, the later the injection is and the more fuel is injected for stratification, the earlier the auto-ignition occurs. However, the experimental findings reveal that the effect of stratification on combustion duration is much more complex. Changes in combustion are reflected in NOX emissions. The attainable level of stratification is limited by the excessive emission of unburned hydrocarbons, CO and soot.

  18. An approach to simple reaction control for auto-thermal fuel-reforming systems

    Energy Technology Data Exchange (ETDEWEB)

    Komachiya, M.; Hiyama, K.; Higashiyama, K. [Hitachi Research Laboratory, Hitachi, Ltd. 1-1, Omika-cho 7-chome, Hitachi-shi Ibaraki-ken (Japan); Okano, T.; Yatabe, H. [Kure Division, Babcock-Hitachi K.K., 6-9 Takara-machi, Kure-shi, Hiroshima-ken (Japan); Imada, N.; Kaku, H. [Kure Research Laboratory, Babcock-Hitachi K.K., 3-36 Takara-machi, Kure-shi, Hiroshima-ken (Japan)

    2004-12-01

    A simple approach to reaction control for autothermal fuel-reforming systems was proposed and examined. The amount of air supplied to the fuel-reforming system was chosen as the variable in the feedback (closed-loop) control operation, and simply by varying the amount of air supplied, it was attempted to control and stabilize the temperature of the auto-thermal reforming reaction. The amounts of other fuels and water were chosen from pre-determined values by open-loop operation. Since the feedback operation was limited to the air-supply mechanism, it was expected that both the hardware structure of the system and its software configurations could be significantly simplified. The applicability of this simple feedback control operation was confirmed experimentally by using a methanol reformer of the direct-injection type. (Abstract Copyright [2004], Wiley Periodicals, Inc.)

  19. Genotoxic damage in auto body shop workers.

    Science.gov (United States)

    Siebel, Anna Maria; Basso da Silva, Luciano

    2010-10-01

    Some studies have shown increased DNA damage among car painters, but other professionals working in auto body and paint shops have not been extensively assessed. The aim of this study was to assess DNA damage in different types of auto body shop workers by measuring micronucleus (MN) levels in exfoliated buccal cells. The mean number of cells with MN per 2000 exfoliated buccal cells was analyzed in three groups of male workers: auto body repair technicians, painters, and office workers (control group). All participants answered a questionnaire inquiring about age, smoking habits, alcohol consumption, work practices, occupational exposure time, job activities, and use of protective equipment. The mean number of cells with MN was 3.50 ± 1.50 in auto body painters, 3.91 ± 2.10 in auto body repair technicians, and 0.80 ± 0.78 in office workers, with a significant difference between the control group and the two other groups (p = 0.0001). Age, occupational exposure time, use of protective masks, alcohol consumption, and smoking habit did not affect MN results. The findings indicate that technicians and painters working in auto body shops are at risk for genotoxic damage, while office workers seem to be protected.

  20. Exposure of Petrol Station Attendants and Auto Mechanics to Premium Motor Sprit Fumes in Calabar, Nigeria

    Directory of Open Access Journals (Sweden)

    N. E. Udonwa

    2009-01-01

    Full Text Available A population-based-cross-sectional survey was carried out to investigate the potential risk of exposure to premium motor spirit (PMS fumes in Calabar, Nigeria, among Automobile Mechanics (AM, Petrol Station Attendants (PSA and the general population. Structured questionnaire was administered on the randomly chosen subjects to elicit information on their exposure to PMS. Duration of exposure was taken as the length of work in their various occupations. Venous blood was taken for methaemoglobin (MetHb and packed cells volume (PCV. Mean MetHb value was higher in AM (7.3% and PSA (5.8% than in the subjects from the general population (2.7%. PCV was lower in PSA (30.8%, than AM (33.3% and the subjects from the general population (40.8%. MetHb level was directly proportional, and PCV inversely related, to the duration of exposure. The study suggested increased exposure to petrol fumes among AM, PSA, and MetHb as a useful biomarker in determining the level of exposure to benzene in petrol vapour.

  1. On-line Auto-Tuning of PI Control of the Superheat for a Supermarket Refrigeration System

    DEFF Research Database (Denmark)

    Yang, Zhenyu; Andersen, Casper; Izadi-Zamanabadi, Roozbeh

    2011-01-01

    An online PI auto-tuning method is proposed for superheat control for a type of supermarket refrigeration systems. The proposed procedure consists of three serial steps: Step-One uses one of the two proposed empirical methods, namely multi-step method and relay method, for modeling initialization...... controller is auto-tuned based on the obtained FOPDT model and the SIMC method in Step-Three. The proposed method is implemented on a real-sized physical system and the experimental results showed a promising potential to apply the proposed method into commercial development....

  2. [Prevention of intrauterine adhesion with auto-crosslinked hyaluronic acid gel: a prospective, randomized, controlled clinical study].

    Science.gov (United States)

    Xiao, Songshu; Wan, Yajun; Zou, Fangjun; Ye, Mingzhu; Deng, Henan; Ma, Jiezhi; Wei, Yingying; Tan, Chen; Xue, Min

    2015-01-01

    To evaluate the efficacy and safety of auto-crosslinked hyaluronic acid (HA) gel for preventing intrauterine adhesion (IUA) after hysteroscopic adhesiolysis. A prospective, randomized, double blinded and controlled clinical trial (level I) was performed. According to American Fertility Society (AFS) scoring system, 120 patients (treatment group: 60 cases, control group: 60 cases) with moderate to severe IUA were enrolled. Upon completion of adhesiolysis, a Foley balloon catheter was first introduced into the uterine cavity and then 3 ml of auto-crosslinked HA gel for patients in the treatment group; patients in the control group, however, only received Foley balloon catheter. Second-look hysteroscopic examination was performed to all patients at 3 months postoperatively for evaluation of IUA. Primary endpoint was the reduction rate of IUA at 3 months after surgery. The secondary endpoints include total AFS score, score of each individual AFS category. At 3 months after surgery, auto-crosslinked HA gel resulted in significantly higher effective rate for reduction of adhesion, the effective rate were 76% (42/55) and 48% (27/56) respectively (P = 0.000 9); the total AFS score of treatment group was 2.1 ± 1.1, and significantly lower than that of control group (3.7 ± 2.5, P = 0.000 8). Application of auto-crosslinked HA gel after surgery significantly enhanced the improvement for each individual patient with regard to their adhesive type and menstrual pattern (P = 0.037 8, P = 0.000 4). The treatment group had significantly lower proportion of patients with moderate to severe adhesive stages than that of control group [13% (7/55) versus 38% (21/56), P = 0.000 6]. No adverse events and complications were observed. Auto-crosslinked HA gel coule be able to reduce IUA, decrease adhesion severity, and improve menopause postoperatively. This absorbable auto-crosslinked HA gel is proposed as a barrier for preventing IUA after intrauterine procedures.

  3. A novel auto-tuning PID control mechanism for nonlinear systems.

    Science.gov (United States)

    Cetin, Meric; Iplikci, Serdar

    2015-09-01

    In this paper, a novel Runge-Kutta (RK) discretization-based model-predictive auto-tuning proportional-integral-derivative controller (RK-PID) is introduced for the control of continuous-time nonlinear systems. The parameters of the PID controller are tuned using RK model of the system through prediction error-square minimization where the predicted information of tracking error provides an enhanced tuning of the parameters. Based on the model-predictive control (MPC) approach, the proposed mechanism provides necessary PID parameter adaptations while generating additive correction terms to assist the initially inadequate PID controller. Efficiency of the proposed mechanism has been tested on two experimental real-time systems: an unstable single-input single-output (SISO) nonlinear magnetic-levitation system and a nonlinear multi-input multi-output (MIMO) liquid-level system. RK-PID has been compared to standard PID, standard nonlinear MPC (NMPC), RK-MPC and conventional sliding-mode control (SMC) methods in terms of control performance, robustness, computational complexity and design issue. The proposed mechanism exhibits acceptable tuning and control performance with very small steady-state tracking errors, and provides very short settling time for parameter convergence. Copyright © 2015 ISA. Published by Elsevier Ltd. All rights reserved.

  4. MPC-based auto-tuned PID controller for the steam generator water level

    International Nuclear Information System (INIS)

    Na, Man Gyun

    2001-01-01

    In this work, proportional-integral-derivative (PID) control gains are automatically tuned by using a model predictive control (MPC) method. The MPC has received much attention as a powerful tool for the control of industrial process systems. An MPC-based PID controller can be derived from the second order linear model of a process. The steam generator is usually described by the well-known 4 th order linear model which consists of the mass capacity, reverse dynamics and mechanical oscillations terms. But the important terms in this linear model are the mass capacity and reverse dynamics terms, both of which can be described by a 2 nd order linear system. The proposed auto-tuned PID controller was applied to a linear model of steam generators. The parameters of a linear model for steam generators are very different according to the power levels. The proposed controller showed good performance for the water level deviation and sudden steam flow disturbances that are typical in the existing power plants by changing only the input-weighting factor according to the power level

  5. AutoSync : Automatic duty-cycle control for synchronous low-power listening

    DEFF Research Database (Denmark)

    Hansen, Morten Tranberg; Kusy, Branislav; Jurdak, Raja

    2012-01-01

    resources doing idle listening. This problem is particularly exacerbated in multi-radio networks where majority of data comes through the most reliable radio and the duty cycles of other radios could be reduced. We address this issue in AutoSync, a protocol that combines synchronous LPL with automatic...... selection of check intervals to reduce energy consumption in both single and multi-radio networks. We first present the justification for AutoSync's design, and we then discuss our implementation of AutoSync in TinyOS. We compare AutoSync against existing protocols in both simulations and empirical...... experiments. Results show that AutoSync attains a substantial increase in the operational lifetime and mean power consumption over existing protocols in single radio networks and even more in dual radio networks....

  6. Occupational exposure to heavy metals in a metal-mechanical auto part manufacturing plant in Puebla, Mexico

    Directory of Open Access Journals (Sweden)

    Maria F Romero-Zarazua

    2015-01-01

    Full Text Available Aims: The concentration of Cd, Cr, Al and Pb present in inhalable air and deposited dust in a metal-mechanical parts manufacturing plant in Puebla, México were determined in order to assess the occupational exposure of workers in this plant. Materials and Methods: Fourteen air samples, six from the metal welding (MW and eight from the metal forming (MF areas, as well as metal dust accumulated on the floor of an auto part manufacturing plant, were collected. Sampling and analysis followed the National Institute for Occupational Safety and Health (NIOSH recommended methods for metals in inhalable air. Results: The average concentration of Al and Cd determined in a volume of inhalable air were adequate under NIOSH maximal exposure concentration limits in both sampled sites. Average concentrations of 0.001 (MF sampling site and 0.105 μg/L (MW sampling site for Al; 0.003 (MF and 0.0005 (MW μg/L for Cd, with respect to the NIOHS limits, 10 and 0.005 μg/L, for Al and Cd, respectively. However, Cr and Pb concentrations exceeded or were close to the limits recommended by NIOHS in both places (0.5 and 0.05 μg/L for Cr and Pb, respectively. Average concentrations of 0.345 (MF and 0.77 (MW μg/L for Cr and 0.153 (MF and 0.649 (MW μg/L for Pb, were determined. Levels of metal content (Cd, Cr and Pb in powder samples collected in both sampling sites were also higher than the suggested limits. Conclusion: The average concentration of Cr and Pb exceeded the limits recommended by the Occupational Safety and Health Administration and NIOSH for inhalable air in the workplace. Workers may be on risk of heavy metal occupational exposure. It is endorsed to implement safety measurements to avoid the breathing of contaminated air and also industrial level systems for dust and aerosol particle filtering or precipitation, altogether with stricter policies to regulate heavy metal exposure at these industries.

  7. Grand Theft Auto IV comes to Singapore: effects of repeated exposure to violent video games on aggression.

    Science.gov (United States)

    Teng, Scott Kie Zin; Chong, Gabriel Yew Mun; Siew, Amy Sok Cheng; Skoric, Marko M

    2011-10-01

    Given the increasingly dominant role of video games in the mainstream entertainment industry, it is no surprise that the scholarly debate about their impact has been lively and well attended. Although >100 studies have been conducted to examine the impact of violent video games on aggression, no clear consensus has been reached, particularly in terms of their long-term impact on violent behavior and aggressive cognitions. This study employs a first-ever longitudinal laboratory-based experiment to examine longer-term effects of playing a violent video game. One hundred thirty-five participants were assigned either to the treatment condition where they played a violent video game in a controlled laboratory setting for a total of 12 hours or to the control group where they did not play a game. Participants in the treatment group played Grand Theft Auto IV over a period of 3 weeks and were compared with a control group on the posttest measures of trait aggression, attitudes toward violence, and empathy. The findings do not support the assertion that playing a violent video game for a period of 3 weeks increases aggression or reduces empathy, but they suggest a small increase in proviolence attitudes. The implications of the findings are discussed.

  8. PID-controller with predictor and auto-tuning algorithm: study of efficiency for thermal plants

    Science.gov (United States)

    Kuzishchin, V. F.; Merzlikina, E. I.; Hoang, Van Va

    2017-09-01

    The problem of efficiency estimation of an automatic control system (ACS) with a Smith predictor and PID-algorithm for thermal plants is considered. In order to use the predictor, it is proposed to include an auto-tuning module (ATC) into the controller; the module calculates parameters for a second-order plant module with a time delay. The study was conducted using programmable logical controllers (PLC), one of which performed control, ATC, and predictor functions. A simulation model was used as a control plant, and there were two variants of the model: one of them was built on the basis of a separate PLC, and the other was a physical model of a thermal plant in the form of an electrical heater. Analysis of the efficiency of the ACS with the predictor was carried out for several variants of the second order plant model with time delay, and the analysis was performed on the basis of the comparison of transient processes in the system when the set point was changed and when a disturbance influenced the control plant. The recommendations are given on correction of the PID-algorithm parameters when the predictor is used by means of using the correcting coefficient k for the PID parameters. It is shown that, when the set point is changed, the use of the predictor is effective taking into account the parameters correction with k = 2. When the disturbances influence the plant, the use of the predictor is doubtful, because the transient process is too long. The reason for this is that, in the neighborhood of the zero frequency, the amplitude-frequency characteristic (AFC) of the system with the predictor has an ascent in comparison with the AFC of the system without the predictor.

  9. Dose budget for exposure control

    International Nuclear Information System (INIS)

    Nair, P.S.

    1999-01-01

    Dose budget is an important management tool to effectively control the collective dose incurred in a nuclear facility. The budget represents a set of yardsticks or guidelines for use in controlling the internal activities, involving radiation exposure in the organisation. The management, through budget can evaluate the radiation protection performance at every level of the organisation where a number of independent functional groups work on routine and non-routine jobs. The discrepancy between the plan and the actual performance is high lighted through the budgets. The organisation may have to change the course of its operation in a particular area or revise its plan with due focus on appropriate protective measures. (author)

  10. Application of Auto CAD

    International Nuclear Information System (INIS)

    Park, Yong Un; Kim, Geun Ho

    1989-05-01

    This book has introduction to use this book and explanation of application on Auto CAD, which includes, sub directories, batch files, robot wrist, design of standard paper, title block, robort weld room, robert wrist joint, PC board, plant sym, electro, PID, machines, robots, bubbles, plant, schema, Pid, plant assembly, robots, dim plant, PL-ASSM, plotting line weight control, symbol drawing joint, Auto CAD using script file, set up of workout · MNU, workout MNU, ACAD, LSP and workout · MNU.

  11. Optimization of supervisory and control systems with implementation of auto tuning based on the IMC technology; Otimizacao de sistemas de supervisao e controle com a implementacao de auto-ajuste baseado na tecnologia IMC

    Energy Technology Data Exchange (ETDEWEB)

    Rubiao, Luiz Eduardo Ganem; Guimaraes, Flavio Martins de Queiroz [CHEMTECH Engenharia, Rio de Janeiro, RJ (Brazil)

    1998-12-31

    The aim of this work is present the results obtained in supervisory systems where an auto tuning tool was implemented. In the chemical, petrochemical and petroleum industry, the great amount of disturbances present in many processes requires the use of automatic controllers to maintain the operational conditions and the products within their specifications. BUt, often, these controllers do not have a self tuning function block in order to adapt the control parameters to the continuous process disturbances. A constant set is usually adopted, although it is only within a specific range of the controlled variable. Nowadays many control systems have supervisory systems running upon them. They could be SCADA, operating in personal computers, or DCS interfaces. Since these systems allow the communication and interface with another software and, sometimes, the need of a flexible change in the control parameters is essential for the process operation, an auto tuning procedure was implemented via software. After a wide search in world market, a commercial auto-tuning software was elected for that task. It is based in the IMC (Internal Model-Based Control) algorithm to determine the initial set of the control parameters and in a proprietary heuristic algorithm, based in pattern recognition, to adapt the parameters to the process disturbances and modifications in the operational conditions. This systems was tested in a pilot for catalysis tests, supervised by FIX DMACS. The results have shown not only a reduction of the time spent for the tuning procedure, due to the systematic methodology, but also expressive gains when extrapolated for production units. (author) 3 refs., 4 figs., 1 tab.

  12. Implication of auto-generated message reminders system (software and rate of absenteeism in orthodontic clinic: A randomized controlled trial

    Directory of Open Access Journals (Sweden)

    Siddharth Sonwane

    2017-01-01

    Full Text Available Context: Absenteeism is a routine pattern of nonattendance from duty of responsibilities, nonattending to given appointment may have deleterious effect on treatment outcome and revenue generation. Very few studies have been done to know the effect of absenteeism on revenue generation and treatment outcome with the help of postcard, telephone, and text messages as reminder; however, these studies have concluded that there was statistically significant difference found in treatment outcome and revenue generation. Furthermore, our study is the almost first to present with the use of current available reminder tool (software reminder system. Aims: The aim of this study to implicate and evaluate effects of auto-generated message reminder (easy dental software application and previous visit reminder system. Materials and Methods: The sum of 180 patients was selected and divided 90 patients in each group. (1 Study group (Auto-generated message reminder system, (2 control group (previous visit remainder. Auto-generated messages were sent to the study group. No formal information given to control group. Statistical Analysis Used: Student's t-tests were used to compare two groups, and logistic regression was obtained 0.044. Results: In control group, 20% of total sample found to be absent whereas only 10% found to be absent in study group. Student's t-test and logistic regression were seen (P = 0.044. Conclusion: The use of auto-generated message reminder system (easy dental software, reduces the rate of absenteeism and increases clinic economy, proper results with stipulated period, and protect both clinician and patients from unwanted complications.

  13. Comparison of a New Auto-controlled Injection System with Traditional Syringe for Mandibular Infiltrations in Children: A Randomized Clinical Trial

    OpenAIRE

    Deepak, Vemula; Challa, Ramasubba Reddy; Kamatham, Rekhalakshmi; Nuvvula, Sivakumar

    2017-01-01

    Background: Pain in the dental operatory can have a profound effect on the behavior of children. Aim: The aim of this study is to evaluate the pain perception while administering local infiltration, in children undergoing dental extractions, using a new auto-controlled injection system. Materials and Methods: Children in the age range of 6?10 years with teeth indicated for extraction were recruited and allocated to either Group I, computer-controlled injection system (auto system with special...

  14. Program auto

    International Nuclear Information System (INIS)

    Rawool-Sullivan, M.W.; Plagnol, E.

    1990-01-01

    The program AUTO was developed to be used in the analysis of dE vs E type spectra. This program is written in FORTRAN and calculates dE vs E lines in MeV. The provision is also made in the program to convert these lines from MeV to ADC channel numbers to facilitate the comparison with the raw data from the experiments. Currently the output of this program can be plotted with the display program, called VISU, but it can also be used independent of the program VISU, with little or no modification in the actual fortran code. The program AUTO has many useful applications. In this article the program AUTO is described along with its applications

  15. Detection of combustion start in the controlled auto ignition engine by wavelet transform of the engine block vibration signal

    International Nuclear Information System (INIS)

    Kim, Seonguk; Min, Kyoungdoug

    2008-01-01

    The CAI (controlled auto ignition) engine ignites fuel and air mixture by trapping high temperature burnt gas using a negative valve overlap. Due to auto ignition in CAI combustion, efficiency improvements and low level NO x emission can be obtained. Meanwhile, the CAI combustion regime is restricted and control parameters are limited. The start of combustion data in the compressed ignition engine are most critical for controlling the overall combustion. In this research, the engine block vibration signal is transformed by the Meyer wavelet to analyze CAI combustion more easily and accurately. Signal acquisition of the engine block vibration is a more suitable method for practical use than measurement of in-cylinder pressure. A new method for detecting combustion start in CAI engines through wavelet transformation of the engine block vibration signal was developed and results indicate that it is accurate enough to analyze the start of combustion. Experimental results show that wavelet transformation of engine block vibration can track the start of combustion in each cycle. From this newly developed method, the start of combustion data in CAI engines can be detected more easily and used as input data for controlling CAI combustion

  16. Easy Korean Auto CAD 14

    International Nuclear Information System (INIS)

    Lee, Jae Cheol

    1997-10-01

    This book introduces Auto CAD 14, which includes summary of basic things of Auto CAD 14, user interface for Auto CAD, basic drawing and advice, layer and set-up drawing, drawing with Auto CAD tools exactly, basic drawing of every thing, edit command, control of display, modeling and view ports of drawing space, various things drawing, writing letters, modification of floor plan, and check, block, X ref, lines and hatch, writing measurement, floor plan and OLE exchange of data, 3D floor plan, and rendering and presentation.

  17. Experimental investigation of the influence of internal and external EGR on the combustion characteristics of a controlled auto-ignition two-stroke cycle engine

    International Nuclear Information System (INIS)

    Andwari, Amin Mahmoudzadeh; Aziz, Azhar Abdul; Said, Mohd Farid Muhamad; Latiff, Zulkarnain Abdul

    2014-01-01

    Highlights: • Investigate the effect of In-EGR, Ex-EGR and octane number on a CAI 2-stroke engine. • Effect of In-EGR, Ex-EGR and octane number on combustion phasing of the engine. • Effect of In-EGR, Ex-EGR and octane number on cyclic variability of the engine. • Identify the CAI combustion upper and lower boundary for operating regions. - Abstract: A two-stroke cycle engine incorporated with a controlled auto-ignition combustion approach presents a high thermodynamic efficiency, ultra-low exhaust emissions and high power-to-weight ratio features for future demand of prime movers. The start of auto-ignition, control of the auto-ignition and its cyclic variability, are major concerns that should be addressed in the combustion timing control of controlled auto-ignition engines. Several studies have been performed to examine the effect of internal exhaust gas recirculation utilization on auto-ignited two-stroke cycle engines. However, far too little attention has been devoted to study on the influence of external exhaust gas recirculation on the cyclic variation and the combustion characteristics of controlled auto-ignition two-stroke cycle engines. The purpose of this study is to examine the influence of external exhaust gas recirculation in combination with internal exhaust gas recirculation on the combustion characteristics and the cyclic variability of a controlled auto-ignition two-stroke engine using fuel with different octane numbers. In a detailed experimental investigation, the combustion-related and pressure-related parameters of the engine are examined and statistically associated with the coefficient of variation and the standard deviation. The outcomes of the investigation indicates that the most influential controlled auto-ignition combustion phasing parameters can be managed appropriately via regulating the internal and external exhaust gas recirculation and fuel octane number. In general, start of auto-ignition and its cyclic variability are

  18. A Novel Therapy for Chronic Sleep-Onset Insomnia: A Retrospective, Nonrandomized Controlled Study of Auto-Adjusting, Dual-Level, Positive Airway Pressure Technology.

    Science.gov (United States)

    Krakow, Barry; Ulibarri, Victor A; McIver, Natalia D; Nadorff, Michael R

    2016-09-29

    Evidence indicates that behavioral or drug therapy may not target underlying pathophysiologic mechanisms for chronic insomnia, possibly due to previously unrecognized high rates (30%-90%) of sleep apnea in chronic insomnia patients. Although treatment studies with positive airway pressure (PAP) demonstrate decreased severity of chronic sleep maintenance insomnia in patients with co-occurring sleep apnea, sleep-onset insomnia has not shown similar results. We hypothesized advanced PAP technology would be associated with decreased sleep-onset insomnia severity in a sample of predominantly psychiatric patients with comorbid sleep apnea. We reviewed charts of 74 severe sleep-onset insomnia patients seen from March 2011 to August 2015, all meeting American Academy of Sleep Medicine Work Group criteria for a chronic insomnia disorder and all affirming behavioral and psychological origins for insomnia (averaging 10 of 18 indicators/patient), as well as averaging 2 or more psychiatric symptoms or conditions: depression (65.2%), anxiety (41.9%), traumatic exposure (35.1%), claustrophobia (29.7%), panic attacks (28.4%), and posttraumatic stress disorder (20.3%). All patients failed continuous or bilevel PAP and were manually titrated with auto-adjusting PAP modes (auto-bilevel and adaptive-servo ventilation). At 1-year follow-up, patients were compared through nonrandom assignment on the basis of a PAP compliance metric of > 20 h/wk (56 PAP users) versus insomnia severity (Hedges' g = 1.72) and sleep-onset insomnia (g = 2.07) compared to partial users (g = 1.04 and 0.91, respectively). Both global and sleep-onset insomnia severity decreased below moderate levels in PAP users compared to partial users whose outcomes persisted at moderately severe levels. In a nonrandomized controlled retrospective study, advanced PAP technology (both auto-bilevel and adaptive servo-ventilation) were associated with large decreases in insomnia severity for sleep-onset insomnia patients who

  19. First industrial application of MAG STT welding with auto adaptative joint control

    International Nuclear Information System (INIS)

    Tran Tien, Thong

    2006-01-01

    The Welding Institute has participated to an extraordinary plan: the manufacture of the new LHC (Large Hadron Collider) particles accelerator in a circular tunnel of 27 km of circumference, at the European laboratory for particles physics (CERN) located at the Franco-Swiss frontier. The LHC dipolar magnets wires constituted in semi-cylinders of 15 m length in 316 LN, thickness 10 mm, are assembled in horizontal-vertical position. The Welding Institute has developed a software allowing to implement the auto-adaptative welding with follow of laser joint, using the MAG STT (Surface Tension Transfer) process. The modeling of welding laws connected with the strategy of joints filling runs (in multi-passes), absorb the physical tolerances of the preparation (clearance, poor alignment, root of joint...) and this in welding dynamical condition. (O.M.)

  20. Techniques for controlling radiation exposure

    International Nuclear Information System (INIS)

    Ocken, H.; Wood, C.J.

    1993-01-01

    The US nuclear power industry has been remarkably successful in reducing worker radiation exposure over the past 10 years. There has been more than a fourfold reduction in person-rem per MW-year of electric power generated: from 1.8 person-rems in 1980 to only 0.4 person-rems in 1991. Despite this substantial improvement, challenges for the industry remain. Individual exposure limits have been tightened in the 1990 Recommendations of the International Commission on Radiological Protection, ICRP Publication 60, and there will be more requirements for special maintenance work as plants age, suggesting that vigorous efforts will be required to meet the 1995 industry goals for unit median collective exposure. No one method will suffice, but implementing suitable combinations from this compendium will help utilities to achieve their exposure goals. Radiation reduction is generally cost-effective: Outages are shorter, staffing requirements are reduced, and work quality is improved. Despite up-front costs, the benefits over the following one to three years typically outweigh the expenses

  1. Dual-harmonic auto voltage control for the rapid cycling synchrotron of the Japan Proton Accelerator Research Complex

    Directory of Open Access Journals (Sweden)

    Fumihiko Tamura

    2008-07-01

    Full Text Available The dual-harmonic operation, in which the accelerating cavities are driven by the superposition of the fundamental and the second harmonic rf voltage, is useful for acceleration of the ultrahigh intensity proton beam in the rapid cycling synchrotron (RCS of Japan Proton Accelerator Research Complex (J-PARC. However, the precise and fast voltage control of the harmonics is necessary to realize the dual-harmonic acceleration. We developed the dual-harmonic auto voltage control system for the J-PARC RCS. We describe details of the design and the implementation. Various tests of the system are performed with the RCS rf system. Also, a preliminary beam test has been done. We report the test results.

  2. Double blind placebo controlled exposure to molds

    DEFF Research Database (Denmark)

    Meyer, H W; Jensen, K A; Nielsen, K F

    2005-01-01

    The objective was to develop an experimental setup for human exposure to mold spores, and to study the clinical effect of this exposure in sensitive subjects who had previously experienced potentially building-related symptoms (BRS) at work. From three water-damaged schools eight employees....... In conclusion this is, to our knowledge, the first study to successfully conduct a human exposure to a highly controlled dose of fungal material aerosolized directly from wet building materials. This short-term exposure to high concentrations of two different molds induced no more reactions than exposure...... to placebo in eight sensitive school employees. However, a statistical type II error cannot be excluded because of the small sample size. PRACTICAL IMPLICATIONS: In this double blind, placebo controlled study of mold exposure changes in symptoms, objective measurements and blood samples were small and mostly...

  3. Comportamento assertivo e sua relação com ansiedade, locus de controle e auto-estima em estudantes universitários

    OpenAIRE

    Bandeira,Marina; Quaglia,Maria Amélia Cesari; Bachetti,Lívia da Silva; Ferreira,Tatiana Lourençoni; Souza,Grasiela Gomide de

    2005-01-01

    Foram estudados o comportamento assertivo e sua relação com ansiedade, locus de controle e auto-estima. Participou da pesquisa uma amostra aleatória de 135 universitários, de ambos os sexos, com idade média de 25 anos. Foram aplicadas as escalas de assertividade de Rathus, locus de controle de Levenson, auto-estima de Dela Coleta e a escala de ansiedade IDATE-traço. Os resultados indicaram que os estudantes da área de ciências exatas apresentaram escores mais elevados de assertividade e de au...

  4. AutoCAD platform customization user interface, AutoLISP, VBA, and beyond

    CERN Document Server

    Ambrosius, Lee

    2015-01-01

    Take control of AutoCAD to boost the speed, quality, and precision of your work Senior drafters and savvy users are increasingly taking AutoCAD customization out of the hands of system administrators, and taking control of their own workflow. In AutoCAD Platform Customization, Autodesk customization guru Lee Ambrosius walks you through a multitude of customization options using detailed tutorials and real-world examples applicable to AutoCAD, AutoCAD LT, Civil 3D, Plant 3D, and other programs built on the AutoCAD platform. By unleashing the full power of the software, you'll simplify and str

  5. Adaptive threshold control for auto-rate fallback algorithm in IEEE 802.11 multi-rate WLANs

    Science.gov (United States)

    Wu, Qilin; Lu, Yang; Zhu, Xiaolin; Ge, Fangzhen

    2012-03-01

    The IEEE 802.11 standard supports multiple rates for data transmission in the physical layer. Nowadays, to improve network performance, a rate adaptation scheme called auto-rate fallback (ARF) is widely adopted in practice. However, ARF scheme suffers performance degradation in multiple contending nodes environments. In this article, we propose a novel rate adaptation scheme called ARF with adaptive threshold control. In multiple contending nodes environment, the proposed scheme can effectively mitigate the frame collision effect on rate adaptation decision by adaptively adjusting rate-up and rate-down threshold according to the current collision level. Simulation results show that the proposed scheme can achieve significantly higher throughput than the other existing rate adaptation schemes. Furthermore, the simulation results also demonstrate that the proposed scheme can effectively respond to the varying channel condition.

  6. PET radiation exposure control for nurses

    International Nuclear Information System (INIS)

    Kawabata, Yumiko; Kikuta, Daisuke; Anzai, Taku

    2005-01-01

    Recently, the number of clinical PET centers is increasing all over Japan. For this reason, the monitoring and control of radiation exposure of employees, especially nurses, in PET-dedicated clinics and institutions are becoming very important issues for their health. We measured the radiation exposure doses of the nurses working at Nishidai Diagnostic Imaging Center, and analyzed the exposure data obtained from them. The exposure doses of the nurses were found to be 4.8 to 7.1 mSv between April 2003 and March 2004. We found that the nurses were mostly exposed to radiation when they had to have contact with patients received an FDG injection or they had trouble with the FDG automatic injection system. To keep radiation exposure of nurses to a minimum we reconfirmed that a proper application of the three principles of protection against radiation exposure was vital. (author)

  7. Post-operative auto-transfusion in total hip or knee arthroplasty: a meta-analysis of randomized controlled trials.

    Directory of Open Access Journals (Sweden)

    Zhao Haien

    Full Text Available Total hip or knee arthroplasty is an elective procedure that is usually accompanied by substantial blood loss, which may lead to acute anemia. As a result, almost half of total joint arthroplasty patients receive allogeneic blood transfusions (ABT. Many studies have shown that post-operative auto-transfusion (PAT significantly reduces the need for ABT, but other studies have questioned the efficacy of this method.The protocol for this trial and supporting CONSORT checklist are available as supporting information; see Checklist S1. To evaluate the efficacy of PAT, we conducted a Cochrane systematic review that combined all available data from randomized controlled trials. Data from the six included trials were pooled for analysis. We then calculated relative risks with 95% confidence intervals (CIs for dichotomous outcomes and mean differences with 95% CIs for continuous outcomes.To our knowledge, this is the first meta-analysis to compare the clinical results between PAT and a control in joint replacement patients. This meta-analysis has proven that the use of a PAT reinfusion system reduced significantly the demand for ABT, the number of patients who require ABT and the cost of hospitalization after total knee and hip arthroplasty. This study, together with other previously published data, suggests that PAT drains are beneficial. Larger, sufficiently powered studies are necessary to evaluate the presumed reduction in the incidence of infection as well as DVT after joint arthroplasty with the use of PAT.

  8. OSHA Bloodborne Pathogens Standards Exposure Control Plan

    Science.gov (United States)

    Luhrs, Caro Elise; Teitelbaum, Rita

    1993-01-01

    The Hummer Associates Exposure Control Plan is designed to reduce significant occupational exposure to bloodborne pathogens and infectious materials for Hummer Associates health care personnel. Under universal precautions, all patients and all body fluids are considered potentially infectious for bloodborne pathogens. Medical personnel need not be at increased risk if universal precautions are correctly understood and followed. This program covers all employees who could reasonably anticipate contact with blood or other potentially infectious materials during the performance of their job responsibilities. Although HIV and hepatitis B are mentioned most often, this program applies to all bloodborne diseases. The two main components needed to implement this program are universal precautions and engineering/work practice controls. This program covers all employees who may have occupational exposure to blood or other potentially infectious materials. Other aspects of this program are discussed.

  9. Controlling exposure to radon, France, December 2006

    International Nuclear Information System (INIS)

    Godet, J.L.; Perrin, M.L.; Dechaux, E.; Pineau, C.

    2007-01-01

    Controlling exposure to radon, France, December 2006 Exposure to radon, along with medical exposure, is the leading source of the French population exposure to ionizing radiation. Radon is a confirmed cause of lung cancer in man (classified in group I by the international Agency for research on Cancer (I.A.R.C.)). According to available estimates, the numbers of lung cancers attributable to radon exposure in France are far fewer than those caused by tobacco. However, according to a recent European study, around 9% of lung cancers in Europe may be caused by radon. Thus, due to the number of people exposed, radon has become a public health issue which calls for action, considering that exposure can be significantly reduced by implementing measures which are often simple. Since 2002, the Nuclear Safety Authority (Asn) has proceeded in implementing a new regulatory framework for the risk management related to the presence of radon in public places. The new system is now fully operational. In addition, based on the initiatives adopted by the government in June 2004 in the context of the National Health and Environment Plan (P.N.S.E.), the Asn drew up a plan in 2005, in collaboration with the Ministry for Urban Planning and Construction, to coordinate the actions of various national bodies involved in this field. This three-pronged strategy is as follows: - Creation of a new risk management policy related to the presence of radon in existing homes and in new buildings; - Supporting and controlling the implementation of regulations for managing radon related risks in public places; - Improvement and dissemination of knowledge on radon exposure and its related risks. (author)

  10. Control voltage of the generator of auto-excited induction for applications on micro/mini generation o electric power; Control de voltaje del generador de induccion auto-excitado para aplicaciones de micro/mini generacion de energia electrica

    Energy Technology Data Exchange (ETDEWEB)

    Torres Montalvo, Emmanuel

    2006-09-15

    Although only one part of the mini/micro hydraulic power has been exploited in our country, this type of electric energy generation can be considered as a visible way of electricity generation, mainly related to the ecological, economical and social aspects. The impact that these power plants can have in the regions in which they are installed is always positive: cost energy cost reduction, economical spills and mainly a social welfare. The electric energy is one of the pillars for the economical development of a country and provides a better life quality. Nowadays the research and the technology oriented to the operation and control of the micro/mini power plants has awaken the interest of many researchers in several countries of the world as China, India, Canada, and USA to mention some of them. The induction generator plays a crucial role in the uses of these technologies. The work of Basset and Potter in 1935 is the angular stone over the possibility of generating energy making use of the induction machine and a capacitors bank connected to the machine terminals. This configuration is known as induction auto-excited generator (GIAE). Several investigations have been realized that deal about the functioning principle and the dynamic behavior a GIAE, which can supply electric power in remote isolated regions. In the existing literature have been proposed control strategies to offer voltage regulations and/or frequency into the acceptable range. Some of these control strategies present problems such a demand of a reactive power, harmonics injections in the system, the control circuits are complicated, expensive and voluminous and prone to fail. This paper realizes an analysis of the necessary and sufficient conditions so that an induction machine can operate as GIAE. The corresponding curves are presented for each studied case. The dynamic behavior of the voltage and the frequency generated by the GIAE are studied in detail, which is a contribution to the existing

  11. [Improving home auto-control in diabetic children: reducing atherogenic risk].

    Science.gov (United States)

    Bayes García, R; Campoy Folgoso, C; Pérez Bonilla, E; Molina Font, J

    1991-03-01

    Insulin-dependent Diabetes (IDDM) is a major endocrine abnormality in children and the greatest morbi-mortality problems for diabetic patients are those related to cardiovascular complications (macro-microangiopaties), where kept hyperlipidemia and hyperglucemia play a fundamental patogenic role. The programs for optimization of home autocontrol have reduced frequent metabolic derangements. The aim of this study was to analyze the metabolic control state and its relationships with plasma lipids and atherogenic ratios in diabetic patients that were submitted to a program for optimization of home autocontrol of this illness. Blood samples were taken fom 49 IDDM, aged 10.53 +/- 0.51 (+/- SEM) years old, with a mean evolution period of 4.34 +/- 0.38 years, at the begining of the program (Stage I) and 6 months later (Stage II). Biochemical Analysis: Total Cholesterol (TC), cholesterol joined to high density lipoprotein (HDLc), Triglycerides (TG) and Phospholipids (Ph) were measured by microspectrphotometric methods. Cholesterol joined to very low and low density lipoproteins (VLDLc and LDLc, respectively) were calculated by Friedwald's formula. Apoproteins A and B (Apo A and Apo B) were measured using Mancini's method, Glycemia levels (Gly) by peroxidase's method, Glycosilated Serum Protein (GSP) by colormetric's method and Glycosilated haemoglobine (HbA1c) by chromatographic separation using cationic interchange microcolumns. 65% of the patients showed a significant decrease in plasma levels of Gly, GSP and HbA1c percentage between Stages I and II (Favourable Metabolic Control).(ABSTRACT TRUNCATED AT 250 WORDS)

  12. Records of radiation exposure control, 4

    International Nuclear Information System (INIS)

    Nakamura, Takashi; Kawabata, Hisao.

    1976-04-01

    The Radiation Control Center controls the radiation levels in and around the Institute to protect mankind and instrument from the radiation hazard. The center is also performing health physics and shielding research cooperating with other health physics and shielding groups. In this report, the records of environmental and personal monitoring of radiation exposure at the Institute for Nuclear Study are accumulated for the period during March 1975 - March 1976. This report includes the technical details of monitoring program and several research activities, skyshine, residual radioactivity, thick target neutron and photon spectra etc., in the Radiation Control Center. (auth.)

  13. Knowledge of allergies and performance in epinephrine auto-injector use: a controlled intervention in preschool teachers.

    Science.gov (United States)

    Dumeier, Henriette Karoline; Richter, Luca Anne; Neininger, Martina Patrizia; Prenzel, Freerk; Kiess, Wieland; Bertsche, Astrid; Bertsche, Thilo

    2018-04-01

    Epinephrine auto-injectors are used for first aid in anaphylactic emergencies by non-healthcare professionals, e.g., (pre-)school teachers. We developed an education session for preschool teachers addressing allergies, anaphylactic emergencies, and administering auto-injectors. We assessed their attitudes and knowledge in allergies and anaphylactic emergency by a questionnaire and monitored their practical performance in administering auto-injectors before the education session, directly after, and 4-12 weeks after the session. From 75 teachers giving their consent to participate, 81% had children with allergies under their supervision and 3% had already administered medication from an available rescue kit. The knowledge of triggers of allergies increased from 9 to 55% directly and to 33% 4-12 weeks after the session (both p < 0.001, compared to baseline). Directly after the session, the number of teachers who felt well-prepared for an anaphylactic emergency rose from 11 to 88%, which decreased to 79% 4-12 weeks thereafter (each p < 0.001). The number of auto-injector administrations without any drug-related problems increased from 3 to 35% directly after the session and shrunk to 16% 4-12 weeks afterwards (both p < 0.025). A single education session substantially improved preschool teachers' attitudes and knowledge in allergies and anaphylactic emergencies. Additionally, their practical performance in auto-injector administration increased. What is Known: • Food allergies are increasing among children. • The knowledge about allergies and anaphylactic emergencies is poor. What is New: • The proportion of teachers who felt well-prepared for an anaphylactic emergency increased after a single education session. • The proportion of auto-injector administrations without any drug-related problems additionally increased due to an education session.

  14. Enzyme controlled glucose auto-delivery for high cell density cultivations in microplates and shake flasks

    Directory of Open Access Journals (Sweden)

    Casteleijn Marco G

    2008-11-01

    Full Text Available Abstract Background Here we describe a novel cultivation method, called EnBase™, or enzyme-based-substrate-delivery, for the growth of microorganisms in millilitre and sub-millilitre scale which yields 5 to 20 times higher cell densities compared to standard methods. The novel method can be directly applied in microwell plates and shake flasks without any requirements for additional sensors or liquid supply systems. EnBase is therefore readily applicable for many high throughput applications, such as DNA production for genome sequencing, optimisation of protein expression, production of proteins for structural genomics, bioprocess development, and screening of enzyme and metagenomic libraries. Results High cell densities with EnBase are obtained by applying the concept of glucose-limited fed-batch cultivation which is commonly used in industrial processes. The major difference of the novel method is that no external glucose feed is required, but glucose is released into the growth medium by enzymatic degradation of starch. To cope with the high levels of starch necessary for high cell density cultivation, starch is supplied to the growing culture suspension by continuous diffusion from a storage gel. Our results show that the controlled enzyme-based supply of glucose allows a glucose-limited growth to high cell densities of OD600 = 20 to 30 (corresponding to 6 to 9 g l-1 cell dry weight without the external feed of additional compounds in shake flasks and 96-well plates. The final cell density can be further increased by addition of extra nitrogen during the cultivation. Production of a heterologous triosphosphate isomerase in E. coli BL21(DE3 resulted in 10 times higher volumetric product yield and a higher ratio of soluble to insoluble product when compared to the conventional production method. Conclusion The novel EnBase method is robust and simple-to-apply for high cell density cultivation in shake flasks and microwell plates. The

  15. Auto-control of pumping operations in sewerage systems by rule-based fuzzy neural networks

    Directory of Open Access Journals (Sweden)

    Y.-M. Chiang

    2011-01-01

    Full Text Available Pumping stations play an important role in flood mitigation in metropolitan areas. The existing sewerage systems, however, are facing a great challenge of fast rising peak flow resulting from urbanization and climate change. It is imperative to construct an efficient and accurate operating prediction model for pumping stations to simulate the drainage mechanism for discharging the rainwater in advance. In this study, we propose two rule-based fuzzy neural networks, adaptive neuro-fuzzy inference system (ANFIS and counterpropagation fuzzy neural network for on-line predicting of the number of open and closed pumps of a pivotal pumping station in Taipei city up to a lead time of 20 min. The performance of ANFIS outperforms that of CFNN in terms of model efficiency, accuracy, and correctness. Furthermore, the results not only show the predictive water levels do contribute to the successfully operating pumping stations but also demonstrate the applicability and reliability of ANFIS in automatically controlling the urban sewerage systems.

  16. Controlling occupational radiation exposure. Alternatives to regulation

    International Nuclear Information System (INIS)

    Sagan, L.A.; Squitieri, R.; Wildman, S.S.

    1980-01-01

    The principal strategy adopted for the control of occupational radiation exposure has been the establishment of standards expressed as maximum permissible exposures. The use of such standards is subject to a number of defects, among which is the neglect of the economic impact of imposing such standards. Furthermore, such standards carry the implication of a threshold for radiation effects, a concept now widely challenged. Lastly, the use of standards makes it impossible to evaluate the efficiency of the regulatory agency or to compare its performance with other similar agencies. An alternative to the use of standards, i.e. cost-benefit analysis, is discussed. The advantages of this technique meet many of the objections to the use of standards alone and allow health and safety resources to be allocated in a manner most likely to save the most lives. The greatest disadvantage of cost-benefit analysis has been the difficulty in evaluating the benefit side of the equation. Although the risks of radiation exposure are not known with precision, they are nevertheless well understood. Therefore, the application of cost-benefit analysis to occupational radiation exposure is rational. There are a number of barriers to reform in the use of standards and the adoption of cost-benefit analysis. These attitudinal and institutional constraints are discussed. The nature of private or market systems of control are discussed, i.e. the use of liability and insurance mechanisms. These also have shortcomings that require further development but are seen as potentially more efficient for both employer and employee than is the use of regulatory standards. (author)

  17. Efficacy of auto-crosslinked hyaluronan gel for adhesion prevention in laparoscopy and hysteroscopy: a systematic review and meta-analysis of randomized controlled trials.

    Science.gov (United States)

    Mais, Valerio; Cirronis, Maria G; Peiretti, Michele; Ferrucci, Giuliano; Cossu, Ester; Melis, Gian B

    2012-01-01

    Prevention of postoperative adhesions is a clinical need. We undertook a systematic review to explore the available clinical evidence of the efficacy of auto-crosslinked hyaluronan gel for postoperative adhesion prevention following endoscopic gynecological surgery. An electronic database search of MEDLINE, Cochrane Database of Systematic Reviews and EMBASE, and a comprehensive hand-search of reference lists of published and review articles were performed. No language restrictions were applied. Randomized controlled trials (RCTs) on the use of auto-crosslinked hyaluronan gel for the prevention of postoperative adhesions in gynecological surgery were included in the meta-analysis if they reported outcomes as evaluated at a blind second-look assessment. Three authors independently selected studies and extracted data on study characteristics, quality and accuracy. The Jadad scoring system was used for validity assessment. Meta-analysis was performed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The outcome was the incidence of postoperative adhesions based on a binary response (present or not present). Only five RCTs were eligible for inclusion in the meta-analysis. The incidence of postoperative adhesions in patients who received auto-crosslinked hyaluronan gel was significantly lower than in patients who underwent standard surgery only. The gel prevented both intraperitoneal adhesions after laparoscopic myomectomy (OR 0.248, 95% CI 0.098, 0.628) and intrauterine adhesions after hysteroscopic surgery (OR 0.408, 95% CI 0.217, 0.766). Further RCTs are needed to assess the efficacy of auto-crosslinked hyaluronan gel in women undergoing different laparoscopic intra-abdominal surgical procedures. Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

  18. Operation control device under radiation exposure

    International Nuclear Information System (INIS)

    Kimura, Kiichi; Murakami, Toichi.

    1994-01-01

    The device of the present invention performs smooth progress of operation by remote control for a plurality of operations in periodical inspections in controlled areas of a nuclear power plant, thereby reducing the operator's exposure dose. Namely, the device monitors the progressing state of the operation by displaying the progress of operation on a CRT of a centralized control device present in a low dose area remote from an operation field through an ITV camera disposed in the vicinity of the operation field. Further, operation sequence and operation instruction procedures previously inputted in the device are indicated to the operation field through an operation instruction outputting device (field CRT) in accordance with the progress of the operation steps. On the other hand, the operation progress can be aided by inputting information from the operation field such as start or completion of the operation steps. Further, the device of the present invention can monitor the change of operation circumstances and exposure dose of operators based on the information from a radiation dose measuring device disposed in the operation circumstance and to individual operators. (I.S.)

  19. [Application of auto-control micro-motion intramedullary locking nail in the treatment of femoral shaft fractures].

    Science.gov (United States)

    Zhang, Hongjun; Liu, Youwen; Gao, Shutu; Du, Zhiqian

    2008-06-01

    The auto-control micro-motion intramedullary locking nail (AMLN) is designed, to reduce the incidence of delayed union and non-union of femoral shaft fractures fixed by interlocking intramedullary nails, and to observe the clinical effect of self-design AMLN in the treatment of femoral shaft fractures. The distal and promixal nails were connected by the micro-motion locking structure, which could cause 1.0-1.5 mm axial micro-motion between fracture gaps. It could produce physical stimulus and conduction between fracture gaps in the course of fracture union. From December 2003 to May 2006, 32 cases of femoral shaft fractures were treated with AMLN, including 21 males and 11 females with the average age of 31.2 years (ranging from 20 years to 43 years). The trauma resulted from fall wounds in 3 cases, crash injuries in 1 case and car accidents in 28 cases. Twenty-nine cases were fresh fractures in different parts of the femoral shaft with transverse, oblique, spiral and comminuted fractures of type I, II, III and IV. Three cases were old non-union fractures. The fresh fractures were treated by closed AMLN fixation, while the old fractures were treated by open AMLN nails after routine implantation of self bone. All the 32 cases were followed up for the average time of 11.5 months (ranging from 8 months to 22 months). The X-ray films showed the fractures were healed 4.0 to 7.5 months after the operation, with the mean time of 5.1 months, and no break of the nail happened. One nail mildly bent in the comminuted fracture, and 2 patients felt slightly unwell at the needling point. According to the Klemm criterion for function, 26 cases were excellent, 5 good, 1 fair, and the choiceness rate was 96.88%. With a suitable design, AMLN is easy to perform and helpful to quicken fracture union, and it is effective to treat femoral shaft fractures.

  20. Robust Constrained Optimization Approach to Control Design for International Space Station Centrifuge Rotor Auto Balancing Control System

    National Research Council Canada - National Science Library

    Postma, Barry D

    2005-01-01

    .... The robustness constraints are posed with respect to parametric uncertainty in the plant. The proposed approach to control design allows for both of these objectives to be handled within the framework of constrained optimization. The resulting controller achieves acceptable performance and robustness characteristics.

  1. Instant AutoIt scripting

    CERN Document Server

    Laso, Emilio Aristides de Fez

    2013-01-01

    Filled with practical, step-by-step instructions and clear explanations for the most important and useful tasks. This is a Packt Instant How-to guide, which provides concise and clear recipes for getting started with AutoIt.Instant AutoIt Scripting Essentials How-to is for beginners who wish to know more about automation and programming, system administration developers who intent to automate/manage clusters and servers, and for computer programmers who want to control any PC to create seamless automation apps.

  2. Effect of automatic exposure control marker with chest radiography in radiation reduction

    International Nuclear Information System (INIS)

    Jung, Ji Sang; Choi, Byoung Wook; Shim, Ji Na; Ahn, Ho Sik; Jin, Duk Eun; Liml, Jae Sik; Kang, Sung Ho; Kim, Sung Ho; Kim, Young Mo

    2014-01-01

    This study focused on effects of patient exposure dose reduction with AEC (Auto Exposure Control) marker that is designed for showing location of AEC in X-ray Chest radiography. It included 880 adults who have to use Chest X-ray Digital Radiography system (DRS, LISTEM, Korea). AEC (Ion chambers are posited in top of both sides) are used to every adult and set X-ray system as Field size 17 x 17 inch, 120 kVp, FFD 180 cm. 440 people of control group are posited on detector to include both sides of lung field and the other 440 people of experimental group are set to contact their lung directly to Ion chamber (making marker to shows location). Then, measured every DAP and, estimated patient effective dose by using PCXMC 2.0. The average age of control group (M:F=245:195) is 53.9 and the average BMI is 23.4. BMI ranges from under weight: 35, normal range: 279, over weight: 106 to obese: 20 and average DAP is 223.56 mGycm2, Mean effective dose is 0.045 mSv. The average age of experimental group (M:F=197:243) is 53.7 and the average BMI is 22.7. BMI ranges from under weight: 34, normal range: 315, over weight: 85 to obese: 6 and average DAP is 207.36 mGycm2, Mean effective dose is 0.041 mSv. Experimental group shows less Mean effective dose as 0.004mSv (9.7%) than control group. Also, patient numbers who got over exposure more than 0.056 mSv (limit point to know efficiency of AEC marker) is 65 in control group(14.7%), 19 in experimental group (4.3%) and take statistics with t-Test. The statistical difference between two groups is 0.006. In order to use proper amount of X-ray in auto exposure controlled chest X-ray system, matching location between ion chamber and body part is needed, and using AEC marker (designed for showing location of ion chamber) is a way to reduce unnecessary patient exposure dose

  3. Monitoring and control of occupational radiation exposure in Switzerland

    International Nuclear Information System (INIS)

    Moser, M.

    1997-01-01

    Occupational exposure is the most prominent example for the prolonged exposure to low level ionizing radiation characterized by low doses and dose rates. In this paper the occupational exposure in Switzerland is presented and the regulatory control of this exposure in the framework of the new radiation protection regulations is discussed. (author)

  4. Easy Auto CAD

    International Nuclear Information System (INIS)

    Lee, Hyeon Jun

    1996-02-01

    This book explains Auto CAD easily, which introduces improved function in Auto CAD R 13, such as direct import and export of 3 DS pile, revised render order structure, and explanations of assist, view Draw, construct and modify. Next it gives descriptions of Auto CAD conception, application and system. The last part deals with line, arc, circle, ellipse, erase, undo, redo, redraw, line type, multi line, limits, zoom, move, copy, rotate, array, mirror, grid, snap, units, offset and poly line.

  5. Assessment and control of fetal exposure

    International Nuclear Information System (INIS)

    Harty, R.; Swinth, K.L.; Traub, R.J.

    1991-10-01

    The assessment and control of fetal exposure to radiation in the workplace is an issue that is complicated by both biological and political/social ramifications. As a result of the dramatic increase in the number of women employed as radiation workers during the past 10 years, many facilities using radioactive materials have instituted fetal protection programs with special requirements for female radiation workers. It is necessary, however, to ensure that any fetal protection program be developed in such a way as to be nondiscriminatory. A study has been initiated whose purpose is to balance the political/social and the biological ramifications associated with occupational protection of the developing embryo/fetus. Several considerations are involved in properly balancing these factors. These considerations include appropriate methods of declaring the pregnancy, training workers, controlling the dose to the embryo/fetus, measuring and calculating the dose to the embryo/fetus, and recording the pertinent information. Alternative strategies for handling these factors while ensuring maximum protection of the embryo/fetus and the rights and responsibilities of employees and employers are discussed

  6. Respirable crystalline silica - a failure to control exposure!

    Science.gov (United States)

    Cain, J. R.

    2009-02-01

    Several sites were visited to monitor stonemason exposure to respirable crystalline silica (RCS), inhalable dust and respirable dust. At all sites, exposure to RCS exceeded the Workplace Exposure Limit of 0.1 mg/m3 8-hour TWA. There was therefore a continuing high risk of workers developing silicosis unless the appropriate measures were instigated to prevent or control exposure. Exposure control was ineffective at all sites e.g. water wall extraction systems were not well designed. There was evidence that foreign workers were at a greater exposure risk. But even with appropriate controls to mitigate exposure to RCS it may not be possible to sustain exposure to below 0.1 mg/m3 8-hour TWA without on-going HSE intervention.

  7. Auto Mechanics: Auto Mechanic Service Specialist (Lubrication).

    Science.gov (United States)

    Hoover, Virgil

    The unit of individualized learning activities is designed to provide training in the job skill, lubrication, for the prospective auto mechanic service specialist. The materials in the unit are divided into two sections. The developmental, or preliminary phase, for use by the instructor, includes brief descriptions of the job and of the student…

  8. AutoCAD workbook

    CERN Document Server

    Metherell, Phil

    1989-01-01

    AutoCAD Workbook helps new users learn the basics of AutoCad, providing guidance on most of the commonly used functions in which the program operates.This book discusses loading AutoCad and starting a drawing; drawing and erasing lines, circles, and arcs; and setting up the drawing environment. The topics on drawing and editing polylines; entering text and text styles; and layers, linetype, and color are also considered. This publication likewise covers creating and using blocks, hatching and extracting information, dimensioning drawings, 3D visualization, and plotting a drawing. Other

  9. Auto immune hepatitis

    OpenAIRE

    van Gerven, Nicole MF; de Boer, Ynto S; Mulder, Chris JJ; van Nieuwkerk, Carin MJ; Bouma, Gerd

    2016-01-01

    To provide an update of the latest trends in epidemiology, clinical course, diagnostics, complications and treatment of auto immune hepatitis (AIH). A search of the MEDLINE database was performed using the search terms: “auto immune hepatitis”, “clinical presentation”, “symptoms”, “signs”, “diagnosis”, “auto antibodies”, “laboratory values”, “serology”, “histopathology”, “histology”, “genetics”, “HLA genes”, “non-HLA genes”, “environment”, “epidemiology”, “prevalence”, “incidence”, “demograph...

  10. Control of radiation exposure (principles and methods)

    International Nuclear Information System (INIS)

    Agwimah, R. I.

    1999-01-01

    Biological risks are directly related to the tissue radiation dose, so it is very important to maintain personnel doses as low as realistically possible. This goal can be achieved by minimizing internal contamination and external exposure to radioactive sources

  11. Double blind placebo controlled exposure to molds

    DEFF Research Database (Denmark)

    Meyer, H W; Jensen, K A; Nielsen, K F

    2005-01-01

    The objective was to develop an experimental setup for human exposure to mold spores, and to study the clinical effect of this exposure in sensitive subjects who had previously experienced potentially building-related symptoms (BRS) at work. From three water-damaged schools eight employees...... with a positive histamine release test to Penicillium chrysogenum were exposed double- blinded to either placebo, approximately 600,000 spores/m3 air of P. chrysogenum or approximately 350,000 spores/m3 of Trichoderma harzianum for 6 min on three separate days. A statistically significant rise in symptoms from...... mucous membranes appeared from the 9-graded symptom scale after exposure to T. harzianum or placebo. Dichotomizing the data, whether the participants experienced at least a two-step rise on the symptom scale or not, gave borderline increase in mucous membrane symptoms after exposure to P. chrysogenum...

  12. PLC Based Hydraulic Auto Ladle System

    OpenAIRE

    Amogh Tayade; Anuja Chitre

    2014-01-01

    In this paper we have implemented a PLC based Hydraulic Auto Ladle System for Casting Department of Victory Precisions Pvt. Ltd. Chakan, Pune. This project work presents the study and design of PLC based Hydraulic Auto Ladle System. Aluminium pouring is the key process in Casting and Forging industry. Different products are manufactured by the company for automobile sector using aluminium. Programmable Logic Controller (PLC) is used for the automation of pouring process. Au...

  13. Spike frequency adaptation is a possible mechanism for control of attractor preference in auto-associative neural networks

    Science.gov (United States)

    Roach, James; Sander, Leonard; Zochowski, Michal

    Auto-associative memory is the ability to retrieve a pattern from a small fraction of the pattern and is an important function of neural networks. Within this context, memories that are stored within the synaptic strengths of networks act as dynamical attractors for network firing patterns. In networks with many encoded memories, some attractors will be stronger than others. This presents the problem of how networks switch between attractors depending on the situation. We suggest that regulation of neuronal spike-frequency adaptation (SFA) provides a universal mechanism for network-wide attractor selectivity. Here we demonstrate in a Hopfield type attractor network that neurons minimal SFA will reliably activate in the pattern corresponding to a local attractor and that a moderate increase in SFA leads to the network to converge to the strongest attractor state. Furthermore, we show that on long time scales SFA allows for temporal sequences of activation to emerge. Finally, using a model of cholinergic modulation within the cortex we argue that dynamic regulation of attractor preference by SFA could be critical for the role of acetylcholine in attention or for arousal states in general. This work was supported by: NSF Graduate Research Fellowship Program under Grant No. DGE 1256260 (JPR), NSF CMMI 1029388 (MRZ) and NSF PoLS 1058034 (MRZ & LMS).

  14. Development and evaluation of an Exposure Control Efficacy Library (ECEL)

    NARCIS (Netherlands)

    Fransman, W.; Schinkel, J.; Meijster, T.; Hemmen, J. van; Tielemans, E.; Goede, H.

    2008-01-01

    Objectives: This paper describes the development and evaluation of an evidence database on the effectiveness of risk management measures (RMMs) to control inhalation exposure. This database is referred to as Exposure Control Efficacy Library (ECEL). Methods: A comprehensive review of scientific

  15. Tagaotsitav "Auto" / Kristiina Vaarik

    Index Scriptorium Estoniae

    Vaarik, Kristiina

    2001-01-01

    Chris O'Connelli "Auto" Vanemuises, lavastaja Mark Babych. Etendusele tegid muusika ansamblist Bizarre tuntud muusikud Tristan Priimägi ja Lauri Liivak, kes artiklis sellest räägivad. Esietendus 2. detsembril 2000

  16. Development of ATSR (Auto Thermal Steam Reformer)

    International Nuclear Information System (INIS)

    Ono, J.; Yoshino, Y.; Kuwabara, T.; Fujisima, S.; Kobayashi, S.; Maruko, S.

    2004-01-01

    'Full text:' Auto-thermal reformers are used popularly for fuel cell vehicle because they are compact and can start up quickly. On the other hand, steam reformers are used for stationary fuel cell power plant because they are good thermal efficiency. While, there are many cases using the auto- thermal reformer for stationary use with expectation of cost reduction in USA, as well. However, they are still insufficient for its durability, compactness and cost. We have been developing the new type of fuel processing system that is auto-thermal steam reformer (ATSR), which is hybrid of a conventional steam reformer (STR) and a conventional auto-thermal reformer (ATR). In this study, some proto-type of ATSR for field test were designed, tried manufacturing and tested performance and durability. And we have tried to operate with fuel cell stack to evaluate the system interface performance, that is, operability and controllability. (author)

  17. Application of Auto CAD 2000

    International Nuclear Information System (INIS)

    Kim, Hyeong Jun

    1999-11-01

    This book deals with basic of AutoCAD, beginning AutoCAD 2000, using design center of AutoCAD 2000, adding drawing element with design center, drawing lines, using 2D edit command, making layer, hatching, dimensioning, entering letters on the floor plan, making 3D object, practice of 3D command, edition of 3D object, making solid, rendering object, and using internet in AutoCAD 2000. This book is introduction of AutoCAD 2000 for beginner.

  18. Wood smoke in a controlled exposure experiment with human volunteers

    DEFF Research Database (Denmark)

    Riddervold, Ingunn Skogstad; Bønløkke, Jakob Hjort; Mølhave, Lars

    2011-01-01

    Exposure to wood smoke in the general population is increasing and concurrently, also our awareness. This article describes a wood-smoke generating system for studying human exposure to wood smoke and symptoms related to this exposure. Twenty nonsmoking atopic human participants with normal lung...... function and normal bronchial reactivity were randomly exposed for 3h at three different exposure conditions; clean filtered air (control exposure) and wood smoke with a characteristic particulate matter (PM) concentration of 200 µg/m3 (low) and 400 µg/m3 (high) under controlled environmental conditions.......0007), “irritative body perceptions” (p = 0.0127), “psychological/neurological effects” (p = 0.0075) and “weak inflammatory responses” (p = 0.0003). Furthermore, significant effects (p = 0.0192) on self-reported general mucosa irritation were found. In conclusion, exposure to wood smoke affected symptom rating...

  19. The Auto control System Based on InTouch Configuration software for High-gravity Oil Railway Tank Feeding

    Directory of Open Access Journals (Sweden)

    Xu De-Kai

    2015-01-01

    Full Text Available This paper provides automatic design for high-gravity oil railway tank feeding system of some refinery uses distributive control system. The system adopts the automatic system of Modicon TSX Quantum or PLC as monitor and control level and uses a PC-based plat form as principal computer running on the Microsoft Windows2000. An automatic control system is developed in the environment of InTouch configuration software. This system implements automatic high-gravity oil tank feeding with pump controlling function. And it combines automatic oil feeding controlling, pump controlling and tank monitoring function to implement the automation of oil feeding with rations and automatic control.

  20. Realtime radiation exposure monitor and control apparatus

    International Nuclear Information System (INIS)

    Cowart, R.W.

    1981-01-01

    This patent application relates to an apparatus and methods used to obtain image information from modulation of a uniform flux. An exposure measuring apparatus is disclosed which comprises a multilayered detector structure having an external circuit connected to a transparent insulating layer and to a conductive plate a radiation source adapted to irradiate the detector structure with radiation capable of producing electron-hole pairs in a photoconductive layer of the detector wherein the flow of current within the external circuit is measured when the detector is irradiated by the radiation source. (author)

  1. PERI auto-tuning

    International Nuclear Information System (INIS)

    Bailey, D H; Williams, S; Chame, J; Chen, C; Hall, M; Dongarra, J; Moore, S; Seymour, K; You, H; Hollingsworth, J K; Tiwari, A; Hovland, P; Shin, J

    2008-01-01

    The enormous and growing complexity of today's high-end systems has increased the already significant challenges of obtaining high performance on equally complex scientific applications. Application scientists are faced with a daunting challenge in tuning their codes to exploit performance-enhancing architectural features. The Performance Engineering Research Institute (PERI) is working toward the goal of automating portions of the performance tuning process. This paper describes PERI's overall strategy for auto-tuning tools and recent progress in both building auto-tuning tools and demonstrating their success on kernels, some taken from large-scale applications

  2. AutoCAD

    DEFF Research Database (Denmark)

    Jensen, Henrik

    1998-01-01

    I 1998 var AutoCAD Arkitektskolens basale CAD-tilbud til de studerende. Kursets vægt ligger på konstruktion og strukturering af 3d-modeller og med udgangspunkt i dette, 2d-tegning. Kurset er opbygget over CAD Clasic skabelonen (se min forskning). Kompendiet kan bruges til selvstudium.......I 1998 var AutoCAD Arkitektskolens basale CAD-tilbud til de studerende. Kursets vægt ligger på konstruktion og strukturering af 3d-modeller og med udgangspunkt i dette, 2d-tegning. Kurset er opbygget over CAD Clasic skabelonen (se min forskning). Kompendiet kan bruges til selvstudium....

  3. AutoCAD

    DEFF Research Database (Denmark)

    Jensen, Henrik

    1998-01-01

    I 1998 var AutoCAD Arkitektskolens basale CAD-tilbud til de studerende. Kursets vægt ligger på konstruktion og strukturering af 3d-modeller og med udgangspunkt i dette, 2d-tegning. Kurset er opbygget over CAD Clasic skabelonen (se min forskning). Kompendiet kan bruges til selvstudium....

  4. The Durban Auto Cluster

    DEFF Research Database (Denmark)

    Lorentzen, Jochen; Robbins, Glen; Barnes, Justin

    2004-01-01

    The paper describes the formation of the Durban Auto Cluster in the context of trade liberalization. It argues that the improvement of operational competitiveness of firms in the cluster is prominently due to joint action. It tests this proposition by comparing the gains from cluster activities...

  5. AUTO-EXPANSIVE FLOW

    Science.gov (United States)

    Physics suggests that the interplay of momentum, continuity, and geometry in outward radial flow must produce density and concomitant pressure reductions. In other words, this flow is intrinsically auto-expansive. It has been proposed that this process is the key to understanding...

  6. AutoCAD 2014 and AutoCAD LT 2014

    CERN Document Server

    Gladfelter, Donnie

    2013-01-01

    A step-by-step tutorial introduction to AutoCAD As the only book to teach AutoCAD using a continuous tutorial which allows you to follow along sequentially or jump in at any exercise by downloading the drawing files, this Autodesk Official Press book is ideal for the AutoCAD novice. Industry expert and AutoCAD guru Donnie Gladfelter walks you through the powerful features of AutoCAD, provides you with a solid foundation of the basics, and shares the latest industry standards and techniques. The hands-on tutorial project inspired by real-world workflows that runs throughout the book

  7. Controlled human exposures to ambient pollutant particles in susceptible populations

    Directory of Open Access Journals (Sweden)

    Ghio Andrew J

    2009-07-01

    Full Text Available Abstract Epidemiologic studies have established an association between exposures to air pollution particles and human mortality and morbidity at concentrations of particles currently found in major metropolitan areas. The adverse effects of pollution particles are most prominent in susceptible subjects, including the elderly and patients with cardiopulmonary diseases. Controlled human exposure studies have been used to confirm the causal relationship between pollution particle exposure and adverse health effects. Earlier studies enrolled mostly young healthy subjects and have largely confirmed the capability of particles to cause adverse health effects shown in epidemiological studies. In the last few years, more studies involving susceptible populations have been published. These recent studies in susceptible populations, however, have shown that the adverse responses to particles appear diminished in these susceptible subjects compared to those in healthy subjects. The present paper reviewed and compared control human exposure studies to particles and sought to explain the "unexpected" response to particle exposure in these susceptible populations and make recommendations for future studies. We found that the causes for the discrepant results are likely multifactorial. Factors such as medications, the disease itself, genetic susceptibility, subject selection bias that is intrinsic to many controlled exposure studies and nonspecificity of study endpoints may explain part of the results. Future controlled exposure studies should select endpoints that are more closely related to the pathogenesis of the disease and reflect the severity of particle-induced health effects in the specific populations under investigation. Future studies should also attempt to control for medications and genetic susceptibility. Using a different study design, such as exposing subjects to filtered air and ambient levels of particles, and assessing the improvement in

  8. Presença de auto-anticorpos não-tireóide-específicos no soro de pacientes com hipotireoidismo auto-imune

    OpenAIRE

    Soares Débora Vieira; Vanderborght Bart O. M.; Vaisman Mário

    2003-01-01

    Auto-anticorpos contra componentes não-específicos da tireóide foram encontrados no soro de pacientes com doença auto-imune da tireóide. Neste estudo avaliamos a presença de auto-anticorpos antinucleares (ANA), antimúsculo liso (anti-ML) e antimitocôndria (anti-Mc) no soro de pacientes com hipotireoidismo auto-imune (HA), comparando-os a controles saudáveis. Estudamos 70 pacientes com hipotireoidismo auto-imune (tireoidite de Hashimoto ou tireoidite atrófica ) e 70 controles saudáveis (sem di...

  9. MS AutoCad

    DEFF Research Database (Denmark)

    Andersen, Michael Rye; Heinicke, Hugo

    1996-01-01

    Formålet med dette notat er at give en introduktion til tegning af et generalarrangement ved anvendelse af CAD-programmet AutoCAD. Generalarrangementets formål er at skabe en overskuelig præsentation af et skibsprojekt. Det skal gøres indenfor de rammer, som ligger til grund for praktiskprojekter......Formålet med dette notat er at give en introduktion til tegning af et generalarrangement ved anvendelse af CAD-programmet AutoCAD. Generalarrangementets formål er at skabe en overskuelig præsentation af et skibsprojekt. Det skal gøres indenfor de rammer, som ligger til grund...

  10. Auto immune hepatitis.

    Science.gov (United States)

    van Gerven, Nicole Mf; de Boer, Ynto S; Mulder, Chris Jj; van Nieuwkerk, Carin Mj; Bouma, Gerd

    2016-05-21

    To provide an update of the latest trends in epidemiology, clinical course, diagnostics, complications and treatment of auto immune hepatitis (AIH). A search of the MEDLINE database was performed using the search terms: "auto immune hepatitis", "clinical presentation", "symptoms", "signs", "diagnosis", "auto antibodies", "laboratory values", "serology", "histopathology", "histology", "genetics", "HLA genes", "non-HLA genes", "environment", "epidemiology", "prevalence", "incidence", "demographics", "complications", "HCC", "PBC", "PSC", "corticosteroid", "therapy", "treatment", "alternative treatment". English-language full-text articles and abstracts were considered. Articles included reviews, meta-analysis, prospective retrospective studies. No publication date restrictions were applied. AIH is an immune meditated progressive inflammatory liver disease that predominantly affects middle-aged females but may affect people of all ages. The clinical spectrum of AIH is wide, ranging from absent or mild symptoms to fulminant hepatic failure. The aetiology of AIH is still unknown, but is believed to occur as the consequence of an aberrant immune response towards an un-known trigger in a genetically susceptible host. In the absence of a gold standard, diagnosis is based on the combination of clinical, biochemical and histopathological criteria. Immunosuppressive treatment has been the cornerstone of treatment since the earliest description of the disease in 1950 by Waldenström. Such treatment is often successful at inducing remission and generally leads to normal life expectancy. Nevertheless, there remain significant areas of unmet aetiological a clinical needs including fundamental insight in disease pathogenesis, optimal therapy, duration of treatment and treatment alternatives in those patients unresponsive to standard treatment regimens.

  11. Sticky situations: cyanoacrylate exposures reported to a poison control system.

    Science.gov (United States)

    Carstairs, Shaun D; Koh, Cynthia; Qian, Lily; Qozi, Mariam; Seivard, Grant; Cantrell, F Lee

    2017-11-01

    Cyanoacrylate (Super Glue ® ) exposures are commonly reported to poison control centers, but little has been published in the medical literature regarding these exposures. We sought to characterize cyanoacrylate exposures reported to a poison control system. We performed a retrospective review of a poison system's database for all cases of single-substance human exposure to cyanoacrylate-containing products from 2005 to 2015. Data collected included age, gender, route of exposure, clinical effects, treatments recommended and medical outcome. There were a total of 893 patients, 505 (56.6%) of which were female. Patient ages ranged from 6 months to 88 years with a median of 11 years. The vast majority of exposures (n = 871, 97.5%) were unintentional, but a small number of exposures (n = 22, 2.5%) were due to intentional misuse (such as trying to stop a bleeding cut) or malicious intent (such as purposefully gluing a person's eyes shut as a prank). Routes of exposure included: ingestion, n = 337 (37.7%); ocular, n = 322 (36.1%); dermatologic, n = 285 (31.9%); inhalation, n = 16 (1.8%); nasal, n = 1 (0.1%); and otic, n = 1 (0.1%); some patients had multiple routes of exposure. Treatments recommended by the poison center included irrigation (n = 411), petroleum jelly (n = 143), mineral oil (n = 131), topical antibiotic ointment (n = 82), peanut butter (n = 6), acetone (n = 4) and WD-40 ® (n = 2). A total of 657 patients (73.6%) were managed on-site, while 236 (26.4%) were seen in a health care facility. Among all exposures, effects were classified as none (n = 287), minor (n = 529) and moderate (n = 77). No major effects or deaths were reported. In this case series, the majority of cases occurred in children and most exposures did not result in significant morbidity. Notably, there was wide variation in terms of recommended treatments; further study is needed to determine the optimal treatment

  12. Occupational Exposure Assessment of Nanomaterials using Control Banding Tools

    DEFF Research Database (Denmark)

    Liguori, Biase

    . In addition, several Control Banding (CB) tools for estimating the exposure to nanomaterials have been developed. An evaluation of current CB tools showed that they are all meant for a qualitative or semi-quantitative exposure assessment of nanomaterials. Two of these tools, NanoSafer and Stoffenmanager Nano......Nanotechnology can be termed as the “new industrial revolution”. A broad range of potential benefits in various applications for the environment and everyday life of humans can be related to the use of nanotechnology. Nanomaterials are used in a large variety of products already in the market...... that there are in general two approaches to assess the exposure of nanomaterials at the workplace: they can be measured or they can be estimated by modelling. It was pointed out that measurements are the standard approach used for the assessment of workplace exposure. However, as highlighted throughout the analysis...

  13. Myocarditis in auto-immune or auto-inflammatory diseases.

    Science.gov (United States)

    Comarmond, Cloé; Cacoub, Patrice

    2017-08-01

    Myocarditis is a major cause of heart disease in young patients and a common precursor of heart failure due to dilated cardiomyopathy. Some auto-immune and/or auto-inflammatory diseases may be accompanied by myocarditis, such as sarcoidosis, Behçet's disease, eosinophilic granulomatosis with polyangiitis, myositis, and systemic lupus erythematosus. However, data concerning myocarditis in such auto-immune and/or auto-inflammatory diseases are sparse. New therapeutic strategies should better target the modulation of the immune system, depending on the phase of the disease and the type of underlying auto-immune and/or auto-inflammatory disease. Copyright © 2017 Elsevier B.V. All rights reserved.

  14. Digital Auto-Oscillator of a Dithering Ring Laser Gyro

    Directory of Open Access Journals (Sweden)

    V. N. Enin

    2015-01-01

    Full Text Available This paper presents a digital auto-oscillator for mechanically dithering Ring Laser Gyro (RLG and method for automatic control of angular oscillation parameters of inertial sensor. A drive signal pulse-width modulation of the auto-oscillator torque sensor excites angular oscillations.Digital auto-oscillator circuit features are as follows: excluding the analog angle sensors from RLG structure, dither signal remover at the RLG output is digital filter, angular rate positive feedback, pulse-width control of auto-oscillator torque sensor by digital signal which provides a preset mode of the dither with random noise.The paper presents a designed mathematical model of the RLG measurement channel together with the auto-oscillator. The mathematical model includes two nonlinearities. The computational experiment allowed us to conduct the following researches: transition process of establishing auto-oscillations since switching on, quasi-steady auto-oscillation mode with frequency and amplitude noise, parameters of auto-oscillations affected by severe operating conditions such as object maneuvers at high speeds and accelerations, high-frequency angular vibration of the RLG base near the resonance frequency of a dither remover. The paper shows efficiency of autooscillator with the specified parameters of a combined type dither with frequency fluctuations.

  15. Inducverters: PLL-Less Converters with Auto-Synchronization and Emulated Inertia Capability

    DEFF Research Database (Denmark)

    Ashabani, Mahdi; Freijedo Fernandez, Francisco Daniel; Golestan, Saeed

    2016-01-01

    -locked-loop (PLL). Therefore, it offers a simpler and more reliable control strategy with improved performance, as it provides real auto-start and auto-synchronization with a grid without the need for grid voltage information. A current damping/synchronization unit enables grid auto-synchronization by using local...

  16. AutoCAD / AutoCAD LT 2014 fundamentals metric

    CERN Document Server

    ASCENT center for technical knowledge

    2014-01-01

    The objective of AutoCAD/AutoCAD LT 2014 Fundamentals is to enable students to create a basic 2D drawing in the AutoCAD software. Even at this fundamental level, the AutoCAD software is one of the most sophisticated computer applications that you are likely to encounter. Therefore learning to use it can be challenging. To make the process easier and provide flexibility for instructors and students, the training guide is divided into two parts that can be taken independently.

  17. Assessment of arsenic exposures and controls in gallium arsenide production.

    Science.gov (United States)

    Sheehy, J W; Jones, J H

    1993-02-01

    The electronics industry is expanding the use of gallium arsenide in the production of optoelectronic devices and integrated circuits. Workers in the electronics industry using gallium arsenide are exposed to hazardous substances such as arsenic, arsine, and various acids. Arsenic requires stringent controls to minimize exposures (the current OSHA PEL for arsenic is 10 micrograms/m3 and the NIOSH REL is 2 micrograms/m3 ceiling). Inorganic arsenic is strongly implicated in respiratory tract and skin cancer. For these reasons, NIOSH researchers conducted a study of control systems for facilities using gallium arsenide. Seven walk-through surveys were performed to identify locations for detailed study which appeared to have effective controls; three facilities were chosen for in-depth evaluation. The controls were evaluated by industrial hygiene sampling. Including personal breathing zone and area air sampling for arsenic and arsine; wipe samples for arsenic also were collected. Work practices and the use of personal protective equipment were documented. This paper reports on the controls and the arsenic exposure results from the evaluation of the following gallium arsenide processes: Liquid Encapsulated Czochralski (LEC) and Horizontal Bridgeman (HB) crystal growing, LEC cleaning operations, ingot grinding/wafer sawing, and epitaxy. Results at one plant showed that in all processes except epitaxy, average arsenic exposures were at or above the OSHA action level of 5 micrograms/m3. While cleaning the LEC crystal pullers, the average potential arsenic exposure of the cleaning operators was 100 times the OSHA PEL. At the other two plants, personal exposures for arsenic were well controlled in LEC, LEC cleaning, grinding/sawing, and epitaxy operations.

  18. Leptospira Exposure and Gardeners: A Case-Control Seroprevalence Study

    Science.gov (United States)

    Alvarado-Esquivel, Cosme; Hernandez-Tinoco, Jesus; Sanchez-Anguiano, Luis Francisco; Ramos-Nevarez, Agar; Cerrillo-Soto, Sandra Margarita; Guido-Arreola, Carlos Alberto

    2016-01-01

    Background Leptospira can be found in soil. However, it is unclear whether occupational exposure to soil may represent a risk for Leptospira infection in humans. Therefore, we sought to determine the association of Leptospira IgG seroprevalence with the occupation of gardener, and to determine the epidemiological characteristics of gardeners associated with Leptospira exposure. Methods We performed a case-control study in 168 gardeners and 168 age- and gender-matched control subjects without gardening occupation in Durango City, Mexico. The seroprevalence of anti-Leptospira IgG antibodies in cases and controls was determined using an enzyme immunoassay. Bivariate and multivariate analyses were used to assess the association of Leptospira exposure and the characteristics of the gardeners. Results Anti-Leptospira IgG antibodies were found in 10 (6%) of 168 gardeners and in 15 (8.9%) of 168 control subjects (odds ratio (OR): 0.64; 95% confidence interval (CI): 0.28 - 1.48; P = 0.40). Multivariate analysis showed that Leptospira seropositivity was positively associated with female gender (OR: 5.82; 95% CI: 1.11 - 30.46; P = 0.03), and negatively associated with eating while working (OR: 0.21; 95% CI: 0.05 - 0.87; P = 0.03). In addition, multivariate analysis showed that high anti-Leptospira levels were associated with consumption of boar meat (OR: 28.00; 95% CI: 1.20 - 648.80; P = 0.03). Conclusions This is the first case-control study of Leptospira exposure in gardeners. Results do not support an association of Leptospira exposure with the occupation of gardener. However, further studies to confirm the lack of this association are needed. The potential role of consumption of boar meat in Leptospira infection deserves further investigation. PMID:26668679

  19. Occupational noise-induced hearing loss in auto part factory workers in welding units in Thailand.

    Science.gov (United States)

    Sriopas, Apiradee; Chapman, Robert S; Sutammasa, Saravudh; Siriwong, Wattasit

    2017-01-24

    Most workers in auto part factories in Thailand are usually exposed to excessive noise in their workplace. This study aimed to assess the level of occupational noise-induced hearing loss and investigate risk factors causing hearing loss in auto part factory workers in the welding units in Thailand. This was a cross-sectional study. One hundred eighty subjects were recruited from 356 workers in the welding unit of three factories. Sixty eligible subjects in each factory were selected by systemic random sampling. The subjects were interviewed using a face-to-face questionnaire. Noise exposure levels and audiograms were measured by a noise dosimeter and an audiometer, respectively. The findings confirmed that noise exposure levels of 86-90 dB (A) and exceeding 90 dB (A) significantly increased the risk of hearing loss in either ear. A noise exposure level exceeding 90 dB (A) significantly increased the prevalence of hearing loss in both ears. Regarding, a 10-pack-year smoking history increased the prevalence of hearing loss in either ear or both ears. In addition, subjects with employment duration exceeding 10 years significantly developed hearing loss in either ear. The engineering control or personal control by wearing hearing protection device should be used to decrease noise exposure levels lower than 85 dB (A) for 8 h. Moreover, if the exposure level reaches 85 dB (A) for 8 h, the employer needs to implement a hearing conservation program in the workplace.

  20. Obtenção de concretos auto-escoantes zero-cimento a partir do controle reológico da matriz Production of self-flow zero-cement castables based on matrix rheological control

    Directory of Open Access Journals (Sweden)

    A. R. Studart

    2000-03-01

    Full Text Available Os concretos refratários auto-escoantes com reduzido teor de cimento têm se destacado pelo fato de associarem a facilidade de aplicação dos concretos de elevada fluidez, com o bom desempenho termomecânico dos refratários contendo baixo teor de CaO. Através do controle simultâneo da distribuição granulométrica e do estado de dispersão da matriz, é possível eliminar o cimento aluminoso (fonte de CaO e quaisquer outros ligantes hidráulicos do concreto, mantendo sua auto-escoabilidade. Os concretos obtidos, denominados zero-cimento, apresentam resistência mecânica a verde compatível com aplicações industriais e excelentes propriedades a altas temperaturas. Neste trabalho, são apresentadas as condições de dispersão da matriz necessárias para a obtenção dos concretos zero-cimento, após um ajuste granulométrico prévio. As faixas de pH e de teor de dispersante ideais para a otimização da reologia da matriz são apresentadas graficamente em um mapa de estabilidade, o qual mostrou-se uma ferramenta bastante útil para a formulação dos concretos auto-escoantes zero-cimento.Self-flow low-cement refractory castables have attracted much attention in the latest years because they combine the installation benefits of high-flowability castables with the good thermomechanical behaviour of low CaO-content refractories. By simultaneously controlling the castable particle size distribution and the matrix dispersion state, it becomes possible to eliminate the aluminous cement (CaO source or any other hydraulic binder in the castable, keeping its self-flow ability. Such castables, named self-flow zero-cement castables, exhibit pre-firing mechanical strength compatible with industrial applications and outstanding high temperature properties. The matrix dispersion conditions necessary to obtain these castables are presented in this work. The optimum range of pH and dispersant amount for the matrix rheological optimisation are

  1. Control of excessive lead exposure in radiator repair workers.

    Science.gov (United States)

    1991-03-01

    In 1988, 83 automotive repair workers with blood lead levels (BLLs) greater than 25 micrograms/dL were reported to state health departments in the seven states that collaborated with CDC's National Institute for Occupational Safety and Health (NIOSH) in maintaining registries of elevated BLLs in adults. In 18 (22%) of these 83 persons, BLLs were greater than 50 micrograms/dL. Among automotive repair workers for whom a job category was specified, radiator repair work was the principal source of lead exposure. The major sources of exposure for radiator repair workers are lead fumes generated during soldering and lead dust produced during radiator cleaning. This report summarizes current BLL surveillance data for radiator repair workers and describes three control technologies that are effective in reducing lead exposures in radiator repair shops.

  2. Controlling criteria for radiation exposure of astronauts and space workers

    International Nuclear Information System (INIS)

    Katoh, Kazuaki

    1989-01-01

    Space workers likely to suffer from radiation exposure in the outer space are currently limited to the U.S. and Soviet Union, and only a small amount of data and information is available concerning the techniques and criteria for control of radiation exposure in this field. Criteria used in the Soviet Union are described first. The criteria (TRS-75), called the Radiation Safety Criteria for Space Navigation, are tentative ones set up in 1975. They are based on risk assessment. The standard radiation levels are established based on unit flight time: 50rem for 1 month, 80rem for 3 months, 110rem for 6 months and 150rem for 12 months. These are largely different from the emergency exposure limit of 100mSv (10rem) specified in a Japanese law, and the standard annual exposure value of 50mSv (5rem) for workers in nuclear power plants at normal times. For the U.S., J.A. Angelo, Jr., presented a paper titled 'Radiation Protection Issues and Techniques concerning Extended Manned Space Missions' at an IAEA meeting held in 1988. Though the criteria shown in the paper are not formal ones at the national level, similar criteria are expected to be adopted by the nation in the near future. The exposure limits recommended in the paper include a depth dose of 1-4Sv for the whole life span of a worker. (Nogami, K.)

  3. Auto-fotografi som metode

    DEFF Research Database (Denmark)

    Mogensen, Mette

    2014-01-01

    Artiklen sætter fokus på auto-fotografi som metode i arbejdsmiljøforskningen. Den organisationsæstetiske tilgang, som metoden ofte forbindes med, udfordres med afsæt i en performativ og aktørnetværks-teoretisk position. Gennem en analyse af et enkelt auto-fotografi vises hvordan en artikulation af...

  4. Radiation exposure control during EMCCR campaign at MAPS

    International Nuclear Information System (INIS)

    Jawahar, S.; Singha Roy, S.

    2003-01-01

    Enmasse Coolant Channel Replacement (EMCCR) work is second of its kind for Indian PHWR- next to RAPS - 2 campaign- after successful demonstration of ability by NPCIL to carry out such major core component maintenance. The Challenges posed during such campaign are mainly attributed to the radiation field, continuous occupancy, and large quantity of material handling for execution as well as preparing infrastructure, exposure control for large number of workmen. Extensive planning was carried out to address all these issues in order to reduce the downtime of the station keeping the collective dose as low as reasonable achievable (ALARA). This paper highlights the strategy adopted, logistics involved in execution of work and the efforts taken to control radiation exposure during this major campaign. (author)

  5. Retrospective exposure assessment and quality control in an international multi-centre case-control study

    DEFF Research Database (Denmark)

    Tinnerberg, H; Heikkilä, P; Huici-Montagud, A

    2003-01-01

    was higher among the original assessors (the assessor from the same country as the subject) than the average prevalence assessed by the other four in the quality control round. The original assessors classified more job situations as exposed than the others. Several reasons for this are plausible: real...... of the assessors, as Cohen's kappa and as overall proportion of the agreements. The reassessment of the exposures changed the exposure statuses significantly, when compared with the original cohort. Harmonization of the exposure criteria increased the conformity of the assessments. The prevalence of exposure...

  6. Occupational exposure in orthopedic procedures under fluoroscopic control

    OpenAIRE

    Edyta Owsiak; Renata Kopeć; Maciej Budzanowski; Maria A. Staniszewska

    2017-01-01

    Background: In interventional radiology the highest radiation doses are usually recorded for both the medical staff and the patients. Interventional procedures with X-rays are implemented in a number of medical specializations. This paper concerns the exposure of interventional teams performing orthopedic procedures under X-rays control. Material and Methods: Doses for interventional teams were measured in the 3 Łódź hospitals. Thermoluminescent dosemeters were applied to measure the followin...

  7. Evaluation of dabigatran exposures reported to poison control centers.

    Science.gov (United States)

    Conway, Susan E; Schaeffer, Scott E; Harrison, Donald L

    2014-03-01

    Dabigatran is a novel oral anticoagulant for which a well-defined range of toxicity and proven antidote has not been established. The primary objective of this study was to characterize dabigatran exposures reported to poison centers by dose ingested, clinical effects, treatments used, and managment sites to gain a better understanding of patient outcomes. A retrospective database review was conducted for dabigatran exposures reported to the National Poison Data System for the American Association of Poison Control Centers (AAPCC) over the period October 2010 to December 2012. There were 802 human dabigatran exposures involving adults predominantly (91% of cases). Exposure chronicity was acute in 43%, acute-on-chronic in 46%, and chronic in 11%, with the most common reason for an exposure call being an unintentional therapeutic error (70.6%). The most common management sites were on-site in 72% of cases and within a health care facility for 26%. Bleeding events and coagulopathies were the most commonly observed clinical effects. Treatments administered included activated charcoal, blood and coagulation products, hemodialysis, and supportive measures. Confirmed outcomes included death in 13 patients (1.6%), major effects in 23 (2.9%), and moderate effects in 50 (6.2%). More severe outcomes were significantly associated with adverse drug reactions, patients ≥65 years of age, those treated with blood and coagulation products and/or dialysis, and renal dysfunction (P < .05). Children experienced few moderate effects and no major effects or deaths. Severe outcomes from dabigatran exposures were not common, occurring in approximately 5% of cases.

  8. Designing for auto safety

    Science.gov (United States)

    Driver, E. T.

    1971-01-01

    Safety design features in the motor vehicle and highway construction fields result from systems analysis approach to prevent or lessen death, injury, and property damage results. Systems analysis considers the prevention of crashes, increased survivability in crashes, and prompt medical attention to injuries as well as other postcrash salvage measures. The interface of these system elements with the driver, the vehicle, and the environment shows that action on the vehicle system produces the greatest safety payoff through design modifications. New and amended safety standards developed through hazard analysis technique improved accident statistics in the 70'; these regulations include driver qualifications and countermeasures to identify the chronic drunken driver who is involved in more than two-thirds of all auto deaths.

  9. Quality control for exposure assessment in epidemiological studies

    DEFF Research Database (Denmark)

    Bornkessel, C; Blettner, M; Breckenkamp, J

    2010-01-01

    In the framework of an epidemiological study, dosemeters were used for the assessment of radio frequency electromagnetic field exposure. To check the correct dosemeter's performance in terms of consistency of recorded field values over the entire study period, a quality control strategy...... was developed. In this paper, the concept of quality control and its results is described. From the 20 dosemeters used, 19 were very stable and reproducible, with deviations of a maximum of +/-1 dB compared with their initial state. One device was found to be faulty and its measurement data had to be excluded...

  10. Control of internal exposure doses of Belarus population

    International Nuclear Information System (INIS)

    Minenko, V.; Drozdovich, V.; Ulanovski, A.; Ternov, V.I.; Vasilyeva, I.

    1997-01-01

    Starting from May 1986 instrumental control of internal exposure is being carried out in Belarus using different equipment. In earlier, iodine period, the basic aim of the control was a mass screening of the population for defining of iodine content in thyroid. After the iodine period attention of the radiological control was focused on monitoring of caesium radionuclides content in human bodies of the inhabitants of radioactively contaminated territories. Goals of the control were changing, depending on the time that passed since the day of the accident. Nowadays the National Commission of Belarus recognizes entering of the, Republic into rehabilitation period of the accident of the Chernobyl Nuclear Power Plant. Developed Conception of Protection Measures for the rehabilitation period for the population living at the territories affected by the radioactive contamination in the result of the Chernobyl catastrophe

  11. Perinatal taurine exposure affects adult arterial pressure control

    Science.gov (United States)

    Roysommuti, Sanya; Wyss, J. Michael

    2012-01-01

    Taurine is an abundant free amino acid found in mammalian cells that contributes to many physiologic functions from that of a simple cell osmolyte to a programmer of adult health and disease. Taurine’s contribution extends from conception throughout life, but its most critical exposure period is during perinatal life. In adults, taurine supplementation prevents or alleviates cardiovascular disease and related complications. In contrast, low taurine consumption coincides with increased risk of cardiovascular disease, obesity and type II diabetes. This review focuses on the effects that altered perinatal taurine exposure has on long-term mechanisms that control adult arterial blood pressure and could thereby contribute to arterial hypertension through its ability to program these cardiovascular regulatory mechanisms very early in life. The modifications of these mechanisms can last a lifetime and transfer to the next generation, suggesting that epigenetic mechanisms underlie the changes. The ability of perinatal taurine exposure to influence arterial pressure control mechanisms and hypertension in adult life appears to involve the regulation of growth and development, the central and autonomic nervous system, the renin-angiotensin system, glucose-insulin interaction and changes to heart, blood vessels and kidney function. PMID:23070226

  12. AutoCAD 2014 essentials

    CERN Document Server

    Onstott, Scott

    2013-01-01

    Learn crucial AutoCAD tools and techniques with this Autodesk Official Press Book Quickly become productive using AutoCAD 2014 and AutoCAD LT 2014 with this full color Autodesk Official Press guide. This unique learning resource features concise, straightforward explanations and real-world, hands-on exercises and tutorials. Following a quick discussion of concepts and goals, each chapter moves on to an approachable hands-on exercise designed to reinforce real-world tactics and techniques. Compelling, full-color screenshots illustrate tutorial steps, and chapters conclude with relat

  13. Control of occupational exposure to cosmic radiation outside the atmosphere

    International Nuclear Information System (INIS)

    Katoh, Kazuaki; Kaneko, Masahito

    2000-01-01

    Japan is participating in the project of constructing ISS, International Space Station, and taking part of constructing JEM, Japan Experimental Module. It is expected that people working in this module upon completion should be controlled their exposure to cosmic radiation according to Japanese laws. Hence, the issue has been studied by a committee in NASDA, National Space Development Agency of Japan. In 1999, its interim report was released and public comments had been invited. In this presentation, following the introduction of the gist of the interim report as well as comments by the authors, countermeasures are proposed. (author)

  14. Effects of space exposure on thermal control coatings

    Science.gov (United States)

    Linton, Roger C.

    1992-01-01

    Optical degradation of selected thermal control coatings exposed on LDEF Experiment A0034, 'Atomic Oxygen Stimulated Outgassing', attributable to effects of solar radiation, was significantly changed for specimens whose exposure included orbital atomic oxygen impingement. This LDEF experiment consisted of two passive modules, one exposed to the total space environment on the Leading Edge (RAM) and another exposed to the relative wake of the Trailing Edge. Evidence of atomic oxygen stimulated outgassing and the interrelated effects of the natural environment based on evaluation of the flight specimens will be discussed.

  15. Optimization of radiation protection for the control of occupational exposure

    International Nuclear Information System (INIS)

    Esseyin, S.S.

    2012-04-01

    This project work provides practical information on how to apply the optimization of protection in the workplace. The principle of optimization states that, all reasonable efforts be made to reduce doses, social and economic factors being taken into account. The main objectives of this project work is to limit the risk to health arising from exposure to ionizing radiation in the workplace and to optimize radiation protection was achieved by setting common essential requirements for the control of exposure to radiation, including the specification of employer and employee duties. The acronym ALARA has been used in this project work as it brings to mind the twin concepts of dose reduction and reasonableness. The other main component of this project work is a general review of the means that are likely to be available in most workplaces to reduce exposure. These are divided into global means, which can be applied throughout an organization and those that are more jobs specific. Some of these global means are no more than would be expected in any well managed organization, such as an application of effective and efficient procedures for the management of work and provision for the education and training of workers. (author)

  16. Sajandi Auto / Willem J. Staat

    Index Scriptorium Estoniae

    Staat, Willem J.

    1998-01-01

    Näitus 'Car of the Century' toimus 27. juunist 5. juulini Amsterdamis, 21. augustist 7. septembrini Torontos. Edasi liigub näitus Pariisi, Melbourne'i ja Lissaboni. Võistluse korraldusest. Lõplikult selgitatakse Sajandi Auto 4. detsembril 1999.

  17. Esma Auto ja Mazda on loodud kestma

    Index Scriptorium Estoniae

    2003-01-01

    Ülevaade olulisematest sündmustest Esma Auto kümne tegevusaasta jooksul. Kommenteerivad Tarmo Järvoja, Mart Laar ja Enn Sau. Diagrammid ja skeemid: AS Esma Auto müügi statistika läbi aastate; AS Esma Auto kasum ja klientide arv aastate lõikes; Esma Auto esindused Eestis ja pakutavad teenused

  18. 30 CFR 56.5005 - Control of exposure to airborne contaminants.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Control of exposure to airborne contaminants... Air Quality and Physical Agents Air Quality § 56.5005 Control of exposure to airborne contaminants. Control of employee exposure to harmful airborne contaminants shall be, insofar as feasible, by prevention...

  19. 30 CFR 57.5005 - Control of exposure to airborne contaminants.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Control of exposure to airborne contaminants... Underground § 57.5005 Control of exposure to airborne contaminants. Control of employee exposure to harmful airborne contaminants shall be, insofar as feasible, by prevention of contamination, removal by exhaust...

  20. Identification of Sources of Endotoxin Exposure as Input for Effective Exposure Control Strategies.

    Science.gov (United States)

    van Duuren-Stuurman, Birgit; Gröllers-Mulderij, Mariska; van de Runstraat, Annemieke; Duisterwinkel, Anton; Terwoert, Jeroen; Spaan, Suzanne

    2018-02-13

    Aim of the present study is to investigate the levels of endotoxins on product samples from potatoes, onions, and seeds, representing a relevant part of the agro-food industry in the Netherlands, to gather valuable insights in possibilities for exposure control measures early in the process of industrial processing of these products. Endotoxin levels on 330 products samples from companies representing the potato, onion, and seed (processing) industry (four potato-packaging companies, five potato-processing companies, five onion-packaging companies, and four seed-processing companies) were assessed using the Limulus Amboecyte Lysate (LAL) assay. As variation in growth conditions (type of soil, growth type) and product characteristics (surface roughness, dustiness, size, species) are assumed to influence the level of endotoxin on products, different types, and growth conditions were considered when collecting the samples. Additionally, waste material, rotten products, felt material (used for drying), and process water were collected. A large variation in the endotoxin levels was found on samples of potatoes, onions, and seeds (overall geometric standard deviation 17), in the range between 0.7 EU g-1 to 16400000 EU g-1. The highest geometric mean endotoxin levels were found in plant material (319600 EU g-1), followed by soil material (49100 EU g-1) and the outer side of products (9300 EU g-1), indicating that removal of plant and soil material early in the process would be an effective exposure control strategy. The high levels of endotoxins found in the limited number of samples from rotten onions indicate that these rotten onions should also be removed early in the process. Mean endotoxin levels found in waste material (only available for seed processing) is similar to the level found in soil material, although the range is much larger. On uncleaned seeds, higher endotoxin levels were found than on cleaned seeds, indicating that cleaning processes are important

  1. Case-control study of leukemia and diagnostic radiation exposure

    International Nuclear Information System (INIS)

    Yuasa, Hidemichi; Hamajima, Nobuyuki; Ueda, Ryuzo

    1997-01-01

    A case-control study of leukemia and diagnostic X-ray exposure was conducted by a multi-institution co-operative study group. The subjects were 134 patients with acute myelogenous leukemia, 57 with chronic myelogenous leukemia, 56 with acute lymphocytic leukemia and 50 with myelodysplasia syndrome, who were between 15 and 79 years old, and diagnosed at one of 27 hospitals between September 1993 and August 1995. The controls were 479 first-visit patients seen at eight of these 27 hospitals. History of diagnostic X-ray tests between 1982 and 1991 was determined by an anonymous self-administered questionnaire. The total relative dose of radiation exposure was calculated by summing the products of given weights and frequencies of each test. The relative risk was 0.83 (95% confidence interval (C.I.), 0.58-1.19) for relative dose of 10-30 (equivalent to 4-11 times of UGI series), 0.76 (0.48-1.20) for relative dose of 30 or more (more than 12 times of UGI series), when compared with relative dose of 0-10 (0-3 times of UGI series). Analysis according to type of leukemia revealed that only acute myelogenous leukemia had an estimated relative risk above unity (1.08, 95%, C.I. 0.69-1.69, for relative dose 10-30). This study did not support the hypothesis that diagnostic X-ray tests increases leukemia risk. (author)

  2. Auto-adaptative Robot-aided Therapy based in 3D Virtual Tasks controlled by a Supervised and Dynamic Neuro-Fuzzy System

    Directory of Open Access Journals (Sweden)

    Luis Daniel Lledó

    2015-03-01

    Full Text Available This paper presents an application formed by a classification method based on the architecture of ART neural network (Adaptive Resonance Theory and the Fuzzy Set Theory to classify physiological reactions in order to automatically and dynamically adapt a robot-assisted rehabilitation therapy to the patient needs, using a three-dimensional task in a virtual reality system. Firstly, the mathematical and structural model of the neuro-fuzzy classification method is described together with the signal and training data acquisition. Then, the virtual designed task with physics behavior and its development procedure are explained. Finally, the general architecture of the experimentation for the auto-adaptive therapy is presented using the classification method with the virtual reality exercise.

  3. Assessment of Factors Related to Auto-PEEP.

    Science.gov (United States)

    Natalini, Giuseppe; Tuzzo, Daniele; Rosano, Antonio; Testa, Marco; Grazioli, Michele; Pennestrì, Vincenzo; Amodeo, Guido; Marsilia, Paolo F; Tinnirello, Andrea; Berruto, Francesco; Fiorillo, Marialinda; Filippini, Matteo; Peratoner, Alberto; Minelli, Cosetta; Bernardini, Achille

    2016-02-01

    Previous physiological studies have identified factors that are involved in auto-PEEP generation. In our study, we examined how much auto-PEEP is generated from factors that are involved in its development. One hundred eighty-six subjects undergoing controlled mechanical ventilation with persistent expiratory flow at the beginning of each inspiration were enrolled in the study. Volume-controlled continuous mandatory ventilation with PEEP of 0 cm H2O was applied while maintaining the ventilator setting as chosen by the attending physician. End-expiratory and end-inspiratory airway occlusion maneuvers were performed to calculate respiratory mechanics, and tidal flow limitation was assessed by a maneuver of manual compression of the abdomen. The variable with the strongest effect on auto-PEEP was flow limitation, which was associated with an increase of 2.4 cm H2O in auto-PEEP values. Moreover, auto-PEEP values were directly related to resistance of the respiratory system and body mass index and inversely related to expiratory time/time constant. Variables that were associated with the breathing pattern (tidal volume, frequency minute ventilation, and expiratory time) did not show any relationship with auto-PEEP values. The risk of auto-PEEP ≥5 cm H2O was increased by flow limitation (adjusted odds ratio 17; 95% CI: 6-56.2), expiratory time/time constant ratio 15 cm H2O/L s (3; 1.3-6.9), age >65 y (2.8; 1.2-6.5), and body mass index >26 kg/m(2) (2.6; 1.1-6.1). Flow limitation, expiratory time/time constant, resistance of the respiratory system, and obesity are the most important variables that affect auto-PEEP values. Frequency expiratory time, tidal volume, and minute ventilation were not independently associated with auto-PEEP. Therapeutic strategies aimed at reducing auto-PEEP and its adverse effects should be primarily oriented to the variables that mainly affect auto-PEEP values. Copyright © 2016 by Daedalus Enterprises.

  4. Controlling exposure to DPM : diesel particulate filters vs. biodiesel

    International Nuclear Information System (INIS)

    Bugarski, A.D.; Shi, X.C.

    2009-01-01

    In order to comply with Mine Safety and Health Administration regulations, mining companies are required to reduce miners exposures to diesel particulate matter (DPM) to 160 μg/m 3 of total carbon. Diesel particulate filter (DPF) systems, disposable filter elements (DFEs), and diesel oxidation catalysts (DOCs) are among the most effective strategies and technologies for curtailing DPM at its source. Substituting diesel fuel with biodiesel blends is also considered to be a plausible solution by many underground mine operators. Studies were conducted at the National Institute for Occupational Safety and Health Diesel Laboratory at Lake Lynn Experimental Mine to evaluate various control technologies and strategies available to the underground mining industry to reduce exposure to DPM. The physical, chemical and toxicological properties of diesel aerosols (DPM) emitted by engines in an underground mine were also evaluated. The DPF and DFE systems were found to be highly effective in reducing total particulate and elemental carbon mass concentrations, total aerosol surface concentrations and, in most cases, concentrations of diesel aerosols in occupational settings such as underground mines. Soy methyl ester (SME) biodiesel fuels had the potential to reduce the mine air concentrations of total DPM, although the rate of reduction varied depending on engine operating conditions. The disadvantage of using biodiesel fuels was an increase in the fraction of particle-bound volatile organics and concentration of aerosols for light-load engine operating conditions.

  5. Obesidade e aspectos psicológicos: maturidade emocional, auto-conceito, locus de controle e ansiedade Obesity and psyhological aspects: emotional and cognitive development, self concept, locus of control and anxiety

    Directory of Open Access Journals (Sweden)

    Caroline Cataneo

    2005-04-01

    Full Text Available Investigou-se, neste trabalho, variáveis psicológicas como locus de controle, auto-conceito, ansiedade, maturação cognitiva e emocional e problemas comportamentais em crianças obesas e não obesas. Participaram do trabalho 54 crianças, com idades entre 10 e 12 anos, sendo 27 crianças obesas, 14 meninas e 13 meninos com índices de massa corporal situados acima do percentil 85, e 27 não obesas, 15 meninas e 12 meninos, com índices de massa corporal entre os percentis 5 e 85. Os grupos não se diferenciaram em relação às variáveis estudadas. Foram verificados resultados indicativos de sofrimento psicológico tanto num grupo quanto no outro, não permitindo associar obesidade e problemas psicológicos ou comportamentais.The present research aimed to evaluate if obese children showed different results in regard to some psychological variables such as emotional and cognitive development, locus of control, self concept , anxiety and behavioral problems compared to non obese children of same age, sex and school achievement. Subjects were 57 children with ages between 10 and 12 years old. The obese group had 27 children, 14 girls and 13 boys. The criterion for assignment to this group was the value of body mass above 85 percentile. The group of non obese had also 27 children, 15 girls and 12 boys and their body mass index was between 5 and 85 percentiles. There were no differences between the groups in regard to the variables approached. There were signs of psychological suffering in children of both groups. These results do not allow us to associate obesity with psychological or behavioral problems.

  6. AutoCAD 2015 and AutoCAD LT 2015

    CERN Document Server

    Gladfelter, Donnie

    2014-01-01

    Learn AutoCAD by example with this tutorial-based guide from Autodesk Official Press Whether you are just starting out or an experienced user wanting to brush up on your skills, this Autodesk Official Press book provides you with concise explanations, focused examples, and step-by-step instructions through a hands-on tutorial project that runs throughout the book. As you progress through the project, the book introduces you to the Microsoft Windows-based AutoCAD interface and then guides you through basic commands and creating drawings. A downloadable file is available from the website so that

  7. AutoCAD 2010 For Dummies

    CERN Document Server

    Byrnes, David

    2009-01-01

    AutoCAD is the hot computer-aided design software known for both its powerful tools and its complexity. AutoCAD 2010 for Dummies is the bestselling guide that walks you through this complicated program so you can build complex 3D technical drawings, edit like a pro, enter new dimensions, and plot with style. AutoCAD 2010 for Dummies helps you navigate the program, use the AutoCAD Design Center, create a basic layout and work with dimension, and put your drawings on the Internet. You'll soon be setting up the AutoCAD environment, using the AutoCAD Ribbon, creating annotation and dimension drawi

  8. Hexavalent chromium exposures and exposure-control technologies in American enterprise: results of a NIOSH field research study.

    Science.gov (United States)

    Blade, L M; Yencken, M Story; Wallace, M E; Catalano, J D; Khan, A; Topmiller, J L; Shulman, S A; Martinez, A; Crouch, K G; Bennett, J S

    2007-08-01

    The National Institute for Occupational Safety and Health (NIOSH) conducted 21 field surveys in selected industries to characterize workers' exposures to hexavalent chromium-containing airborne particulate and to evaluate existing technologies for controlling these exposures. Hexavalent chromium Cr(VI) is a respiratory irritant and chronic inhalation may cause lung cancer. Primary evaluation methods included collection of full work shift, personal breathing-zone (PBZ) air samples for Cr(VI), measurement of ventilation system parameters, and documentation of processes and work practices. This study emphasized evaluation of engineering exposure control measures, so PBZ exposures were measured on the outside of personal protective equipment, for example, respirators. Field surveys were conducted in two chromium electroplating facilities, including one where full-shift PBZ exposures to Cr(VI) ranged from 3.0 to 16 times the 1 micro g/m(3)NIOSH recommended exposure limit (REL) despite several engineering controls on the plating tanks. At a painting and coating facility that used Cr(VI)-containing products, full-shift exposures of painters and helpers (2.4 to 55 micro g/m(3)) exceeded the REL, but LEV effectiveness was limited. Other operations evaluated included welding in construction; metal cutting operations on chromium-containing materials in ship breaking; chromate-paint removal with abrasive blasting; atomized alloy-spray coating; foundry operations; printing; and the manufacture of refractory brick, colored glass, prefabricated concrete products, and treated wood products. NIOSH researchers concluded that, in many of the evaluated processes, Cr(VI) exposures at or below the current NIOSH REL are achievable. However, for some processes, it is unclear whether controlling exposures to this range is consistently achievable without respirator use. Some operations involving the application of coatings and finishes may be among those most difficult to control to this

  9. New perspectives on auto propane

    International Nuclear Information System (INIS)

    Webb, R.F.

    1991-01-01

    In spite of the high level of propane use in vehicles in North America (relative to the use of compressed natural gas (CNG) or methanol), the alternate-fuel research and development activities of original equipment manufacturers (OEMs) are focusing on methanol, CNG, and electric vehicles. If OEM indifference to propane continues, propane vehicles will continue to be available only in after-market conversions, denying propane the benefits of OEM mass-production economics, quality control, retail distribution, and other factors. Recent developments in auto propane are reported which should be considered by OEMs and policymakers to allow propane to enter the mass-scale motor vehicle market. Propane and the liquefied petroleum gas (LPG) mix used as a motor vehicle fuel are often regarded as just a byproduct of natural gas production and oil refining, giving the impression that propane/LPG will not be available in sufficient quantities to support a mass market. It is shown that LPG supply is market-responsive and that over 20 billion gal of new supply could be made available from North American sources by the year 2000 and over 27 billion gal by 2005, sufficient to supply 12.5% of the projected North American vehicle fleet in 2005. The new supply would come from incremental expansion of existing production, displacement of LPG from lower-value uses, and LPG synthesis. The environmental performance of propane/LPG engines is also compared to that of engines running on gasoline, natural gas, and methanol. Advantages of LPG over gasoline include lower carbon content and lower CO emissions, and advantages over CNG arise from the high greenhouse gas activity and long life of methane. 12 figs

  10. Application of a pilot control banding tool for risk level assessment and control of nanoparticle exposures.

    Science.gov (United States)

    Paik, Samuel Y; Zalk, David M; Swuste, Paul

    2008-08-01

    Control banding (CB) strategies offer simplified solutions for controlling worker exposures to constituents that are found in the workplace in the absence of firm toxicological and exposure data. These strategies may be particularly useful in nanotechnology applications, considering the overwhelming level of uncertainty over what nanomaterials and nanotechnologies present as potential work-related health risks, what about these materials might lead to adverse toxicological activity, how risk related to these might be assessed and how to manage these issues in the absence of this information. This study introduces a pilot CB tool or 'CB Nanotool' that was developed specifically for characterizing the health aspects of working with engineered nanoparticles and determining the level of risk and associated controls for five ongoing nanotechnology-related operations being conducted at two Department of Energy research laboratories. Based on the application of the CB Nanotool, four of the five operations evaluated in this study were found to have implemented controls consistent with what was recommended by the CB Nanotool, with one operation even exceeding the required controls for that activity. The one remaining operation was determined to require an upgrade in controls. By developing this dynamic CB Nanotool within the realm of the scientific information available, this application of CB appears to be a useful approach for assessing the risk of nanomaterial operations, providing recommendations for appropriate engineering controls and facilitating the allocation of resources to the activities that most need them.

  11. Impact of Smoke Exposure on Digital Instrumentation and Control

    International Nuclear Information System (INIS)

    Tanaka, Tina J.; Nowlen, Steven P.; Korsah, Kofi; Wood, Richard T.; Antonescu, Christina E.

    2003-01-01

    Smoke can cause interruptions and upsets in active electronics. Because nuclear power plants are replacing analog with digital instrumentation and control systems, qualification guidelines for new systems are being reviewed for severe environments such as smoke and electromagnetic interference. Active digital systems, individual components, and active circuits have been exposed to smoke in a program sponsored by the U.S. Nuclear Regulatory Commission. The circuits and systems were all monitored during the smoke exposure, indicating any immediate effects of the smoke. The results of previous smoke exposure studies have been reported in various publications. The major immediate effect of smoke has been to increase leakage currents and to cause momentary upsets and failures in digital systems. This paper presents new results from conformal coatings, memory chips, and hard drive tests.The best conformal coatings were found to be polyurethane, parylene, and acrylic (when applied by dipping). Conformal coatings can reduce smoke-induced leakage currents and protect against metal loss through corrosion. However conformal coatings are typically flammable, so they do increase material flammability. Some of the low-voltage biased memory chips failed during a combination of high smoke and high humidity. Typically, smoke along with heat and humidity is expected during fire, rather than smoke alone. Thus, due to high sensitivity of digital circuits to heat and humidity, it is hypothesized that the impact of smoke may be secondary.Low-voltage (3.3-V) static random-access memory (SRAMs) were found to be the most vulnerable to smoke. Higher bias voltages decrease the likelihood of failure. Erasable programmable read-only memory (EPROMs) and nonvolatile SRAMs were very smoke tolerant. Failures of the SRAMs occurred when two conditions were present: high density of smoke and high humidity. As the high humidity was present for only part of the test, the failures were intermittent. All

  12. 78 FR 68447 - Exposure Draft-Standards for Internal Control in the Federal Government

    Science.gov (United States)

    2013-11-14

    ... GOVERNMENT ACCOUNTABILITY OFFICE Exposure Draft--Standards for Internal Control in the Federal... revisions to the Standards for Internal Control in the Federal Government, known as the ``Green Book,'' to... proposed changes contained in the 2013 Exposure Draft update to the Standards for Internal Control in the...

  13. 78 FR 52532 - Exposure Draft-Standards for Internal Control in the Federal Government

    Science.gov (United States)

    2013-08-23

    ... GOVERNMENT ACCOUNTABILITY OFFICE Exposure Draft--Standards for Internal Control in the Federal... to the Standards for Internal Control in the Federal Government, known as the ``Green Book,'' under... Exposure Draft update to the Standards for Internal Control in the Federal Government reflect major...

  14. Feedback circuit design of an auto-gating power supply for low-light-level image intensifier

    Science.gov (United States)

    Yang, Ye; Yan, Bo; Zhi, Qiang; Ni, Xiao-bing; Li, Jun-guo; Wang, Yu; Yao, Ze

    2015-11-01

    This paper introduces the basic principle of auto-gating power supply which using a hybrid automatic brightness control scheme. By the analysis of current as image intensifier to special requirements of auto-gating power supply, a feedback circuit of the auto-gating power supply is analyzed. Find out the reason of the screen flash after the auto-gating power supply assembled image intensifier. This paper designed a feedback circuit which can shorten the response time of auto-gating power supply and improve screen slight flicker phenomenon which the human eye can distinguish under the high intensity of illumination.

  15. A review of automatic exposure control of conventional and digital systems

    International Nuclear Information System (INIS)

    Workman, A.; Cowen, A.R.

    1989-01-01

    The desirable properties and methods of achieving automatic exposure control in film-screen radiography, fluoroscopy, spot-film fluorography and cinefluorography are discussed. Advantages of certain methods in achieving optimum image quality for minimal patient exposure are considered. In digital subtraction fluorography (DSF) where relatively large exposure levels per image are used, proper set-up of exposure conditions is of particular importance. These systems require a high degree of stability in exposure to maintain a high level of image quality. We have developed test methods for monitoring the set-up and reproducibility of exposure levels in DSF. (author)

  16. AutoCAD platform customization VBA

    CERN Document Server

    Ambrosius, Lee

    2015-01-01

    Boost productivity and streamline your workflow with expert AutoCAD: VBA programming instruction AutoCAD Platform Customization: VBA is the definitive guide to personalizing AutoCAD and the various programs that run on the AutoCAD platform, including AutoCAD Architecture, Civil 3D, Plant 3D, and more. Written by an Autodesk insider with years of customization and programming experience, this book features detailed discussions backed by real-world examples and easy-to-follow tutorials that illustrate each step in the personalization process. Readers gain expert guidance toward managing layout

  17. AutoCAD platform customization autolisp

    CERN Document Server

    Ambrosius, Lee

    2014-01-01

    Customize and personalize programs built on the AutoCAD platform AutoLISP is the key to unlocking the secrets of a more streamlined experience using industry leading software programs like AutoCAD, Civil 3D, Plant 3D, and more. AutoCAD Platform Customization: AutoLISP provides real-world examples that show you how to do everything from modifying graphical objects and reading and setting system variables to communicating with external programs. It also features a resources appendix and downloadable datasets and customization examples-tools that ensure swift and easy adoption. Find out how to r

  18. AutoCAD 2008 for dummies

    CERN Document Server

    Byrnes, David

    2007-01-01

    A gentle, humorous introduction to this fearsomely complex software that helps new users start creating 2D and 3D technical drawings right awayCovers the new features and enhancements in the latest AutoCAD version and provides coverage of AutoCAD LT, AutoCAD''s lower-cost siblingTopics covered include creating a basic layout, using AutoCAD DesignCenter, drawing and editing, working with dimensions, plotting, using blocks, adding text to drawings, and drawing on the InternetAutoCAD is the leading CAD software for architects, engineers, and draftspeople who need to create detailed 2D and 3D tech

  19. AutoCAD 2014 for dummies

    CERN Document Server

    Fane, Bill

    2013-01-01

    Find your way around AutoCAD 2014 with this full-color, For Dummies guide!Put away that pencil and paper and start putting the power of AutoCAD 2014 to work in your CAD projects and designs. From setting up your drawing environment to using text, dimensions, hatching, and more, this guide walks you through AutoCAD basics and provides you with a solid understanding of the latest CAD tools and techniques. You'll also benefit from the full-color illustrations that mirror exactly what you'll see on your AutoCAD 2014 screen and highlight the importance of AutoCAD's Mode

  20. Evaluation of automatic exposure control systems in computed tomography

    International Nuclear Information System (INIS)

    Reina, Thamiris Rosado

    2014-01-01

    The development of the computed tomography (CT) technology has brought wider possibilities on diagnostic medicine. It is a non-invasive method to see the human body in details. As the CT application increases, it raises the concern about patient dose, because the higher dose levels imparted compared to other diagnostic imaging modalities. The radiology community (radiologists, medical physicists and manufacturer) are working together to find the lowest dose level possible, without compromising the diagnostic image quality. The greatest and relatively new advance to lower the patient dose is the automatic exposure control (AEC) systems in CT. These systems are designed to ponder the dose distribution along the patient scanning and between patients taking into account their sizes and irradiated tissue densities. Based on the CT scanning geometry, the AEC-systems are very complex and their functioning is yet not fully understood. This work aims to evaluate the clinical performance of AEC-systems and their susceptibilities to assist on possible patient dose optimizations. The approach to evaluate the AEC-systems of three of the leading CT manufacturers in Brazil, General Electric, Philips and Toshiba, was the extraction of tube current modulation data from the DICOM standard image sequences, measurement and analysis of the image noise of those image sequences and measurement of the dose distribution along the scan length on the surface and inside of two different phantoms configurations. The tube current modulation of each CT scanner associated to the resulted image quality provides the performance of the AECsystem. The dose distribution measurements provide the dose profile due to the tube current modulation. Dose measurements with the AEC-system ON and OFF were made to quantify the impact of these systems regarding patient dose. The results attained give rise to optimizations on the AEC-systems applications and, by consequence, decreases the patient dose without

  1. [Stress and auto-immunity].

    Science.gov (United States)

    Delévaux, I; Chamoux, A; Aumaître, O

    2013-08-01

    The etiology of auto-immune disorders is multifactorial. Stress is probably a participating factor. Indeed, a high proportion of patients with auto-immune diseases report uncommon stress before disease onset or disease flare. The biological consequences of stress are increasingly well understood. Glucocorticoids and catecholamines released by hypothalamic-pituitary-adrenal axis during stress will alter the balance Th1/Th2 and the balance Th17/Treg. Stress impairs cellular immunity, decreases immune tolerance and stimulates humoral immunity exposing individuals to autoimmune disease among others. The treatment for autoimmune disease should include stress management. Copyright © 2012 Société nationale française de médecine interne (SNFMI). Published by Elsevier SAS. All rights reserved.

  2. Control of occupational exposure in nuclear facilities for terrestrial support to marine vessels

    International Nuclear Information System (INIS)

    Lara, E.G.; Pinheiro, A.R.M.; Borsoi, S.S.; Silva, T.P.; Baroni, D.B.; Santos, F.C.

    2017-01-01

    This study addresses some basic requirements for exposure control of occupational exposure during the design phase of ground-based nuclear facilities for marine vessels. US regulatory guidelines, CNEN standards and experiences acquired in conventional nuclear installations were used. The installation design should consider the provision of mobile devices for monitoring and decontamination. Finally, it is observed that the establishment of additional exposure control criteria can directly impact the civil, architectural and electromechanical projects of the facility, from the conceptual phase

  3. Multiple sclerosis and exposure to house pets during childhood and adolescence : a case-control study

    NARCIS (Netherlands)

    De Keyser, J; Zwanikken, C

    1997-01-01

    Multiple sclerosis (MS) might be triggered by an infectious agent early in life. In a case-control study, we compared exposure to household pets for the age periods 0-5, 6-10, 11-15 and 16-20 years in 100 patients with MS and 100 controls. Exposure to household dogs between the ages of 0-10 years

  4. A Comparison of Exposure Control Procedures in CAT Systems Based on Different Measurement Models for Testlets

    Science.gov (United States)

    Boyd, Aimee M.; Dodd, Barbara; Fitzpatrick, Steven

    2013-01-01

    This study compared several exposure control procedures for CAT systems based on the three-parameter logistic testlet response theory model (Wang, Bradlow, & Wainer, 2002) and Masters' (1982) partial credit model when applied to a pool consisting entirely of testlets. The exposure control procedures studied were the modified within 0.10 logits…

  5. A Comparison of Exposure Control Procedures in CATs Using the 3PL Model

    Science.gov (United States)

    Leroux, Audrey J.; Lopez, Myriam; Hembry, Ian; Dodd, Barbara G.

    2013-01-01

    This study compares the progressive-restricted standard error (PR-SE) exposure control procedure to three commonly used procedures in computerized adaptive testing, the randomesque, Sympson-Hetter (SH), and no exposure control methods. The performance of these four procedures is evaluated using the three-parameter logistic model under the…

  6. Pattern of chlorine gas exposures reported to Texas poison control centers, 2000 through 2005.

    Science.gov (United States)

    Becker, Marcia; Forrester, Mathias

    2008-03-01

    Exposure to chlorine gas can result in serious adverse effects including death. From 2000 through 2005, approximately 9000 chlorine gas exposures were reported annually to poison control centers in the United States. Because a review of the literature failed to produce any Texas-specific data concerning chlorine gas exposures, we conducted a retrospective review of Texas poison control center calls and found that 2643 calls related to human exposures to chlorine gas occurred during these 6 years. The number of these calls increased during this period. Of the exposures, 750% occurred at home and 65% occurred during the months of May through August. Inhalation was the primary mode of exposure. While most exposures resulted in no or minor affects, approximately one-fourth required that the affected person be seen at a health care facility. Preventive activities are needed to educate people about the potential dangers associated with products that contain chlorine.

  7. High speed auto-charging system for condenser bank

    International Nuclear Information System (INIS)

    Mizuno, Yasunori; Bito, Fumio; Fujita, Kazuhiko; Sometani, Taro

    1987-01-01

    A current-control type high-speed charging system, which is intended for auto-charging of the condenser bank, is developed. Moreover, the system can also serve to compensate the current leakage from the condenser bank so that the charged voltage can be kept constant. The system consists of a sequence circuit, a charging current control circuit (or auto-charging circuit) and a charging circuit. The auto-charging circuit is characterized by the use of a triac to control the current. The current, controlled by the circuit, is supplied to the condenser bank through a step-up transformer and voltage doubler rectifier circuit. It is demonstrated that the use of the high-speed auto-charging circuit can largely decrease the required charging time, compared to constant voltage charging. In addition, the compensation function is shown to serve effectively for maintaining a constant voltage after the completion of charging. The required charging time is decreases as the charging current increases. The maximum charging current is decided by the rating of the traic and the current rating of the rectifier diode in the secondary circuit. Major components of these circuits have decreased impedances to minimize the effect of noise, so that the possibility of an accident can be eliminated. Other various improvements are made in the grounding circuit and the charging protection circuit in order to ensure safety. (Nogami, K.)

  8. CONTROLLED EXPOSURES OF HUMAN VOLUNTEERS TO DIESEL ENGINE EXHAUST: BIOMARKERS OF EXPOSURE AND HEALTH OUTCOMES

    Science.gov (United States)

    Combustion of diesel fuel contributes to ambient air pollutant fine particulate matter (PM) and gases. Fine PM exposure has been associated with increased mortality due to adverse cardiac events, and morbidity, such as increased hospitalization for asthma symptoms and lung infect...

  9. Assessment of human exposures to animal vaccines using poison control records, 2000-2009.

    Science.gov (United States)

    Edison, L; Schulte, J; Schauben, J; Kay, R; Rubin, C

    2014-05-01

    To characterize human exposures to vaccines intended for animals, evaluate the human risk due to these exposures and determine whether there is sufficient surveillance in place to monitor them. Retrospective analysis of surveillance data (2000-2009). Information collected by poison specialists during calls reporting human exposure to an animal vaccine product, made to one of the 57 United States Poison Control Centers. Data from the National Poison Data System were analysed to determine the number of calls due to human exposures to animal vaccines, and descriptive statistics were generated to characterize the exposures by age, gender, medical outcome, exposure site, exposure route, vaccine type and intended species, aetiologic agent, call date and exposure reason. Overall, the human health effects were minor, primarily due to unintentional parenteral exposure. Less than 15% of the reports were classified as occupational, and 80% of the exposures took place outside of a workplace or healthcare facility. Almost 60% of calls were due to exposure to the West Nile Virus vaccine; the others distributed among a variety of vaccines. Unintentional exposure to animal vaccines appears to occur almost exclusively among untrained individuals who may benefit from more effective education about the risks and benefits of administering vaccines. Improved reporting of adverse outcomes is essential to adequately define the extent of human exposure and risks associated with availability of new vaccines. © 2013 Blackwell Verlag GmbH.

  10. Controlled human exposure to indoor air, dust, and ozone; XDOZ

    DEFF Research Database (Denmark)

    Elholm, Grethe; Bønløkke, Jakob; Schlünssen, Vivi

    2017-01-01

    of subjective symptoms and general perception of the indoor environment.Results: For most of the participants’ no symptom variation was seen with varied exposures. However for the FVC and the FEV1/FVC ratios a significant association with different chamber exposures were seen.Conclusion: The dust and ozone......Background: Modern citizens spend approximately 90 % of their time indoor. Several studies have indicated that airborne particulate matter and dust affect the comfort and health of occupants of normal non-industrial buildings.Aim: To test if the presence of ozone potentate the discomfort and health....... All participants were subjected to four different exposure scenarios in the climate chamber.Exp. 1: Dust (250 – 300 µg/m3)Exp. 2: Ozone (100 ppb)Exp. 3: Dust (250 – 300 µg/m3) + ozone (100 ppb)Exp. 4: Filtered air (<20µg/m3)The exposure time was 5½ hours for each session.The health effects were...

  11. Acute effects of acrolein in human volunteers during controlled exposure

    Science.gov (United States)

    Dwivedi, Aishwarya M.; Johanson, Gunnar; Lorentzen, Johnny C.; Palmberg, Lena; Sjögren, Bengt; Ernstgård, Lena

    2015-01-01

    Abstract Context: Acrolein is a reactive aldehyde mainly formed by combustion. The critical effect is considered to be irritation of the eyes and airways; however, the scarce data available make it difficult to assess effect levels. Objective: The aim of the study was to determine thresholds for acute irritation for acrolein. Methods: Nine healthy volunteers of each sex were exposed at six occasions for 2 h at rest to: clean air, 15 ppm ethyl acetate (EA), and 0.05 ppm and 0.1 ppm acrolein with and without EA (15 ppm) to mask the potential influence of odor. Symptoms related to irritation and central nervous system effects were rated on 100-mm Visual Analogue Scales. Results: The ratings of eye irritation were slightly but significantly increased during exposure to acrolein in a dose-dependent manner (p test) with a median rating of 8 mm (corresponding to “hardly at all”) at the 0.1 ppm condition and with no influence from EA. No significant exposure-related effects were found for pulmonary function, or nasal swelling, nor for markers of inflammation and coagulation in blood (IL-6, C-reactive protein, serum amyloid A, fibrinogen, factor VIII, von Willebrand factor, and Clara cell protein) or induced sputum (cell count, differential cell count, IL-6 and IL-8). Blink frequency recorded by electromyography was increased during exposure to 0.1 ppm acrolein alone but not during any of the other five exposure conditions. Conclusion: Based on subjective ratings, the present study showed minor eye irritation by exposure to 0.1 ppm acrolein. PMID:26635308

  12. Tailoring automatic exposure control toward constant detectability in digital mammography

    Energy Technology Data Exchange (ETDEWEB)

    Salvagnini, Elena, E-mail: elena.salvagnini@uzleuven.be [Department of Imaging and Pathology, Medical Physics and Quality Assessment, KUL, Herestraat 49, Leuven B-3000, Belgium and SCK-CEN, Boeretang 200, Mol 2400 (Belgium); Bosmans, Hilde [Department of Imaging and Pathology, Medical Physics and Quality Assessment, KUL, Herestraat 49, Leuven B-3000, Belgium and Department of Radiology, UZ Gasthuisberg, Herestraat 49, Leuven B-3000 (Belgium); Struelens, Lara [SCK-CEN, Boeretang 200, Mol 2400 (Belgium); Marshall, Nicholas W. [Department of Radiology, UZ Gasthuisberg, Herestraat 49, Leuven B-3000 (Belgium)

    2015-07-15

    Purpose: The automatic exposure control (AEC) modes of most full field digital mammography (FFDM) systems are set up to hold pixel value (PV) constant as breast thickness changes. This paper proposes an alternative AEC mode, set up to maintain some minimum detectability level, with the ultimate goal of improving object detectability at larger breast thicknesses. Methods: The default “OPDOSE” AEC mode of a Siemens MAMMOMAT Inspiration FFDM system was assessed using poly(methyl methacrylate) (PMMA) of thickness 20, 30, 40, 50, 60, and 70 mm to find the tube voltage and anode/filter combination programmed for each thickness; these beam quality settings were used for the modified AEC mode. Detectability index (d′), in terms of a non-prewhitened model observer with eye filter, was then calculated as a function of tube current-time product (mAs) for each thickness. A modified AEC could then be designed in which detectability never fell below some minimum setting for any thickness in the operating range. In this study, the value was chosen such that the system met the achievable threshold gold thickness (T{sub t}) in the European guidelines for the 0.1 mm diameter disc (i.e., T{sub t} ≤ 1.10 μm gold). The default and modified AEC modes were compared in terms of contrast-detail performance (T{sub t}), calculated detectability (d′), signal-difference-to-noise ratio (SDNR), and mean glandular dose (MGD). The influence of a structured background on object detectability for both AEC modes was examined using a CIRS BR3D phantom. Computer-based CDMAM reading was used for the homogeneous case, while the images with the BR3D background were scored by human observers. Results: The default OPDOSE AEC mode maintained PV constant as PMMA thickness increased, leading to a reduction in SDNR for the homogeneous background 39% and d′ 37% in going from 20 to 70 mm; introduction of the structured BR3D plate changed these figures to 22% (SDNR) and 6% (d′), respectively

  13. Exposure of eyes to perfume: a double-blind, placebo-controlled experiment.

    Science.gov (United States)

    Elberling, J; Duus Johansen, J; Dirksen, A; Mosbech, H

    2006-08-01

    Environmental perfume exposure can elicit bothersome respiratory symptoms. Symptoms are induced at exposure levels which most people find tolerable, and the mechanisms are unclear. The aim of the study was to investigate patients with eye and respiratory symptoms related to environmental perfume, by exposing the eyes to perfume in a double-blind, placebo-controlled study.Twenty-one eczema patients with respiratory symptoms elicited by perfume were compared with 21 healthy volunteers in a sex- and age-matched case-control study. The participants completed a symptom questionnaire, and underwent a double-blind, placebo-controlled exposure to perfume. Of the 42 individuals tested, 10 had more eye symptoms (irritation, itching, and tears) during perfume exposure than during placebo exposures, and eight of these individuals (P = 0.07, Fisher's exact test) belonged to the patient group. A true positive eye reaction to perfume was significantly associated with identification of perfume as an active exposure (P perfume elicited irritation in the eyes independently of olfaction, but the relative importance of ocular chemoperception in relation to elicitation of respiratory symptoms from common environmental exposures to perfume remains unclear. We investigated the hypothesis of an association between respiratory symptoms related to perfume and ocular perfume sensitivity by exposing the eyes to perfume in a double blind, placebo-controlled experiment. Vapors of perfume provoked symptoms in the relevant eye in some patients and healthy control persons, but under our exposure conditions, ocular chemesthesis failed to elicit respiratory symptoms.

  14. Acute effects of acrolein in human volunteers during controlled exposure.

    Science.gov (United States)

    Dwivedi, Aishwarya M; Johanson, Gunnar; Lorentzen, Johnny C; Palmberg, Lena; Sjögren, Bengt; Ernstgård, Lena

    2015-01-01

    Acrolein is a reactive aldehyde mainly formed by combustion. The critical effect is considered to be irritation of the eyes and airways; however, the scarce data available make it difficult to assess effect levels. The aim of the study was to determine thresholds for acute irritation for acrolein. Nine healthy volunteers of each sex were exposed at six occasions for 2 h at rest to: clean air, 15 ppm ethyl acetate (EA), and 0.05 ppm and 0.1 ppm acrolein with and without EA (15 ppm) to mask the potential influence of odor. Symptoms related to irritation and central nervous system effects were rated on 100-mm Visual Analogue Scales. The ratings of eye irritation were slightly but significantly increased during exposure to acrolein in a dose-dependent manner (p acrolein alone but not during any of the other five exposure conditions. Based on subjective ratings, the present study showed minor eye irritation by exposure to 0.1 ppm acrolein.

  15. Does negative auto-regulation increase gene duplicability?

    Directory of Open Access Journals (Sweden)

    Lercher Martin J

    2009-08-01

    Full Text Available Abstract Background A prerequisite for a duplication to spread through and persist in a given population is retaining expression of both gene copies. Yet changing a gene's dosage is frequently detrimental to fitness. Consequently, dosage-sensitive genes are less likely to duplicate. However, in cases where the level of gene product is controlled, via negative feedback, by its own abundance, an increase in gene copy number can in principle be decoupled from an increase in protein while both copies remain expressed. Using data from the transcriptional networks of E. coli and S. cerevisiae, we test the hypothesis that genes under negative auto-regulation show enhanced duplicability. Results Controlling for several known correlates of duplicability, we find no statistically significant support in either E. coli or S. cerevisiae that transcription factors under negative auto-regulation hold a duplicability advantage over transcription factors with no auto-regulation. Conclusion Based on the analysis of transcriptional networks in E. coli and S. cerevisiae, there is no evidence that negative auto-regulation has contributed, on a genome-wide scale, to the variability in gene family sizes in these species.

  16. Exposure to benzene in a pooled analysis of petroleum industry case-control studies.

    Science.gov (United States)

    Glass, D C; Schnatter, A R; Tang, G; Armstrong, T W; Rushton, L

    2017-11-01

    Cases of lymphohematopoietic cancer from three petroleum industry cohorts, matched to controls from the respective cohort, were pooled into single study. Average benzene exposure was quantitatively estimated in ppm for each job based on measured data from the relevant country, adjusted for the specific time period, site and job exposure characteristics and the certainty of the exposure estimate scored. The probability of dermal exposure and of peak exposure was also assessed. Before risk was examined, an exposure estimate comparison and rationalisation exercise was performed across the studies to ensure accuracy and consistency of approach. This article evaluates the final exposure estimates and their use in the risk assessments. Overall benzene exposure estimates were low: 90% of participants accumulated less than 20 ppm-years. Mean cumulative exposure was estimated as 5.15 ppm-years, mean duration was 22 years, and mean exposure intensity was 0.2 ppm. 46% of participants were allocated a peak exposure (>3 ppm at least weekly). 40% of participants had a high probability of dermal exposure (based on the relative probability of at least weekly exposure). There were differences in mean intensity of exposure, probability of peak, and/or dermal exposure associated with job category, job site, and decade of exposure. Terminal Operators handling benzene-containing products were the most highly exposed group, followed by Tanker Drivers carrying gasoline. Exposures were higher around 1940-1950 and lower in more recent decades. Overall confidence in the exposure estimates was highest for recently held jobs and for white-collar jobs. We used sensitivity analyses, which included and excluded case-sets on the basis of exposure certainty scores, to inform the risk assessment. The above analyses demonstrated that the different patterns of exposure across the three studies are largely attributable to differences in jobs, site types, and time frames rather than study. This

  17. A suggested guideline for exposure control from natural radioactivity in future buildings

    International Nuclear Information System (INIS)

    Nambi, K.S.V.; Shukla, V.K.

    1991-01-01

    Naturally occurring radionuclides in building materials are one of the sources of radiation exposure to the population. Their concentrations vary by about 2 to 3 orders of magnitude at different geographical locations. This paper proposes three control methodologies for keeping the population exposure as low as reasonably achievable. Tentative recommendations are also included. (author). 11 refs., 3 tabs., 2 appendixes

  18. AutoPyFactory and the Cloud

    CERN Document Server

    Caballero, J; The ATLAS collaboration; Love, P

    2013-01-01

    AutoPyFactory (APF) is a next-generation pilot submission framework that has been used as part of the ATLAS workload management system (PANDA) for two years. APF is reliable, scalable, and offers easy and flexible configuration. Using a plugin-based architecture, APF polls for information from configured information and batch systems (including grid sites), decides how many additional pilot jobs are needed, and submits them. With the advent of cloud computing, providing resources goes beyond submitting pilots to grid sites. Now, the resources on which the pilot will run also need to be managed. Handling both pilot submission and controlling the virtual machine life cycle (creation, retirement, and termination) from the same framework allows robust and efficient management of the process. In this paper we describe the design and implementation of these virtual machine management capabilities of APF. Expanding on our plugin-based approach, we allow cascades of virtual resources associated with a job queue. A si...

  19. Optimization of radiation protection in the control of occupational exposure

    International Nuclear Information System (INIS)

    2002-01-01

    One of the three main principles on which protection against ionizing radiation is based is the principle of the optimization of radiological protection. The principle of the optimization of protection was first enunciated by the International Commission on Radiological Protection in the 1960s. A principal requirement for the optimization of protection and safety has been incorporated into the International Basic Safety Standards for Protection against Ionizing Radiation and for the Safety of Radiation Sources (Basic Safety Standards) from the first edition in 1962 up to the current (1996) edition. The principle of optimization, that all reasonable efforts be made to reduce doses (social and economic factors being taken into account), necessitates considerable effort to apply in practice. The requirement of the Basic Safety Standards to apply the principle of optimization applies to all categories of exposure: occupational, public and medical. The categories of public and medical exposure are rather specific and are covered in other publications; this Safety Report concentrates on the application of the principle to what is probably the largest category, that of occupational exposure. This Safety Report provides practical information on how to apply the optimization of protection in the workplace. The emphasis throughout is on the integration of radiation protection into the more general system of work management, and on the involvement of management and workers in setting up a system of radiation protection and in its implementation. This Safety Report was drafted and finalized in three consultants meetings held in 1999 and 2000. The draft was sent for review and comment to a number of experts, which yielded valuable comments from a number of reviewers whose names are included in the list of contributors to drafting and review

  20. Optimization of radiation protection in the control of occupational exposure

    International Nuclear Information System (INIS)

    2003-01-01

    One of the three main principles on which protection against ionizing radiation is based is the principle of the optimization of radiological protection. The principle of the optimization of protection was first enunciated by the International Commission on Radiological Protection in the 1960s. A principal requirement for the optimization of protection and safety has been incorporated into the International Basic Safety Standards for Protection against Ionizing Radiation and for the Safety of Radiation Sources (Basic Safety Standards) from the first edition in 1962 up to the current (1996) edition. The principle of optimization, that all reasonable efforts be made to reduce doses (social and economic factors being taken into account), necessitates considerable effort to apply in practice. The requirement of the Basic Safety Standards to apply the principle of optimization applies to all categories of exposure: occupational, public and medical. The categories of public and medical exposure are rather specific and are covered in other publications. This Safety Report concentrates on the application of the principle to what is probably the largest category, that of occupational exposure. This Safety Report provides practical information on how to apply the optimization of protection in the workplace. The emphasis throughout is on the integration of radiation protection into the more general system of work management, and on the involvement of management and workers in setting up a system of radiation protection and in its implementation. This Safety Report was drafted and finalized in three consultants meetings held in 1999 and 2000. The draft was sent for review and comment to a number of experts, which yielded valuable comments from a number of reviewers whose names are included in the list of contributors to drafting and review

  1. Optimization of radiation protection in the control of occupational exposure

    International Nuclear Information System (INIS)

    2004-01-01

    One of the three main principles on which protection against ionizing radiation is based is the principle of the optimization of radiological protection. The principle of the optimization of protection was first enunciated by the International Commission on Radiological Protection in the 1960s. A principal requirement for the optimization of protection and safety has been incorporated into the International Basic Safety Standards for Protection against Ionizing Radiation and for the Safety of Radiation Sources (Basic Safety Standards) from the first edition in 1962 up to the current (1996) edition. The principle of optimization, that all reasonable efforts be made to reduce doses (social and economic factors being taken into account), necessitates considerable effort to apply in practice. The requirement of the Basic Safety Standards to apply the principle of optimization applies to all categories of exposure: occupational, public and medical. The categories of public and medical exposure are rather specific and are covered in other publications. This Safety Report concentrates on the application of the principle to what is probably the largest category, that of occupational exposure. This Safety Report provides practical information on how to apply the optimization of protection in the workplace. The emphasis throughout is on the integration of radiation protection into the more general system of work management, and on the involvement of management and workers in setting up a system of radiation protection and in its implementation. This Safety Report was drafted and finalized in three consultants meetings held in 1999 and 2000. The draft was sent for review and comment to a number of experts, which yielded valuable comments from a number of reviewers whose names are included in the list of contributors to drafting and review

  2. Isocyanate exposure control in motor vehicle paint spraying: evidence from biological monitoring.

    Science.gov (United States)

    Jones, Kate; Cocker, John; Piney, Mark

    2013-03-01

    The purpose of this work was to assess the changes in control of exposure to hexamethylene diisocyanate based paints used in vehicle spraying after a Health & Safety Executive (HSE) national project. Paint sprayers and managers from motor vehicle repair (MVR) bodyshops across the UK, were invited to one of 32 Safety and Health Awareness Days (SHADs) to increase their understanding of the hazards, and practical ways of controlling of exposure to isocyanate based paints. Exposure measurement based on biological monitoring was offered, free of charge, to each of the roughly 4000 participants and used to assess the effectiveness of controls and methods of working. Results are compared with pre and post SHAD measurements. Urine samples were received from 995 paint sprayers. Hexamethylene diamine (HDA) levels in urine, indicative of exposure to hexamethylene diisocyanate (HDI), were significantly lower (Mann-Whitney, psmall and micro businesses. Biological monitoring of exposure has enabled individual companies, and sprayers, to check that their control measures are working. This study showed overall lower levels of HDA in paint sprayers following SHADs. These lower levels have been maintained across a wider population of UK paint sprayers over the succeeding years. Whilst there may be many reasons for the reduction in exposure, the weight of evidence suggests that the key messages about exposure control measures, delivered through the SHADs and other means, were influential.

  3. A case control study of breast cancer risk and exposure to injectable ...

    African Journals Online (AJOL)

    A case control study of breast cancer risk and exposure to injectable progestogen contraceptives. R. Bailie, J Katzenellenbogen, M. Hoffman, G Schierhout, H Truter, D Dent, A Gudgeon, J van Zyl, L Rosenberg, S Shapiro ...

  4. Controlled light-exposure microscopy reduces photobleaching and phototoxicity in fluorescence live-cell imaging.

    NARCIS (Netherlands)

    Hoebe, R.A.; van Oven, C.H.; Gadella, Th.W.J.; Dhonukshe, P.B.; van Noorden, C.J.F.; Manders, E.M.M.

    2007-01-01

    Fluorescence microscopy of living cells enables visualization of the dynamics and interactions of intracellular molecules. However, fluorescence live-cell imaging is limited by photobleaching and phototoxicity induced by the excitation light. Here we describe controlled light-exposure microscopy

  5. Controlled light-exposure microscopy reduces photobleaching and phototoxicity in fluorescence live-cell imaging

    NARCIS (Netherlands)

    Hoebe, R. A.; van Oven, C. H.; Gadella, T. W. J.; Dhonukshe, P. B.; van Noorden, C. J. F.; Manders, E. M. M.

    2007-01-01

    Fluorescence microscopy of living cells enables visualization of the dynamics and interactions of intracellular molecules. However, fluorescence live-cell imaging is limited by photobleaching and phototoxicity induced by the excitation light. Here we describe controlled light-exposure microscopy (

  6. Systematic Review of Control Measures to Reduce Hazardous Drug Exposure for Health Care Workers.

    Science.gov (United States)

    Crickman, Rachael; Finnell, Deborah

    2016-01-01

    Because of their involvement in the transport, handling, preparation, administration, or disposal of hazardous medications, health care workers across multiple settings are at risk for adverse health consequences from exposure to these drugs. This review presents evidence-based strategies to mitigate the harmful exposures. These include engineering controls, full use of personal protective equipment, medical and environmental monitoring, hazard identification, and the need for a comprehensive hazardous drug control program that includes education and training for health care workers.

  7. AutoCAD 2015 and AutoCAD LT 2015 bible

    CERN Document Server

    Finkelstein, Ellen

    2014-01-01

    The perfect reference for all AutoCAD users AutoCAD 2015 and AutoCAD LT 2015 Bible is the book you want to have close at hand to answer those day-to-day questions about this industry-leading software. Author and Autodesk University instructor Ellen Finkelstein guides readers through AutoCAD 2015 and AutoCAD LT 2015 with clear, easy-to-understand instruction and hands-on tutorials that allow even total beginners to create a design on their very first day. Although simple and fundamental enough to be used by those new to CAD, the book is so comprehensive that even Autodesk power u

  8. Evaluation of the approach to respirable quartz exposure control in U.S. coal mines.

    Science.gov (United States)

    Joy, Gerald J

    2012-01-01

    Occupational exposure to high levels of respirable quartz can result in respiratory and other diseases in humans. The Mine Safety and Health Adminstration (MSHA) regulates exposure to respirable quartz in coal mines indirectly through reductions in the respirable coal mine dust exposure limit based on the content of quartz in the airborne respirable dust. This reduction is implemented when the quartz content of airborne respirable dust exceeds 5% by weight. The intent of this dust standard reduction is to restrict miners' exposure to respirable quartz to a time-weighted average concentration of 100 μg/m(3). The effectiveness of this indirect approach to control quartz exposure was evaluated by analyzing respirable dust samples collected by MSHA inspectors from 1995 through 2008. The performance of the current regulatory approach was found to be lacking due to the use of a variable property-quartz content in airborne dust-to establish a standard for subsequent exposures. In one situation, 11.7% (4370/37,346) of samples that were below the applicable respirable coal mine dust exposure limit exceeded 100 μg/m(3) quartz. In a second situation, 4.4% (895/20,560) of samples with 5% or less quartz content in the airborne respirable dust exceeded 100 μg/m(3) quartz. In these two situations, the samples exceeding 100 μg/m(3) quartz were not subject to any potential compliance action. Therefore, the current respirable quartz exposure control approach does not reliably maintain miner exposure below 100 μg/m(3) quartz. A separate and specific respirable quartz exposure standard may improve control of coal miners' occupational exposure to respirable quartz.

  9. Auto-immune Haemolytic Anaemia and Paroxys

    African Journals Online (AJOL)

    who presented with an acute auto-immune haemolytic anaemia. In addition to a persistently positive Coombs test, with specific red cell auto-antibodies, the acidified serum test and the sucrose haemolysis test were repeatedly positive. CASE REPORT. A 24-year-old Indian woman was admitted to hospital in. July 1969.

  10. Inducverters: PLL-Less Converters with Auto-Synchronization and Emulated Inertia Capability

    OpenAIRE

    Ashabani, Mahdi; Freijedo Fernandez, Francisco Daniel; Golestan, Saeed; Guerrero, Josep M.

    2016-01-01

    In this paper, the idea of operation of grid connected voltage source converters (VSCs) by similar characteristics of induction machines under new concept of inducverter is proposed and developed. The proposed controller eliminates the need for an extra synchronization unit and phase-locked-loop (PLL). Therefore, it offers a simpler and more reliable control strategy with improved performance, as it provides real auto-start and auto-synchronization with a grid without the need for grid voltag...

  11. Environmental radioactivity: the importance of controlling exposure of the public: some experiences in Cuba

    International Nuclear Information System (INIS)

    Fernandez Gomez, Isis Maria

    2008-01-01

    The nuclear power is offering considerable advantages, it is considering the option to produce energy and the economy has moved in favour of the nuclear power. Therefore, the security is important within of the industry because ensures the control of public exposure and the environment and it plays a crucial role. Public exposure refers to exposure that is not of the direct work with ionizing radiation or the application of nuclear techniques in medical treatment and diagnosis. There are potential sources of discharges into the environment as the spent fuel and the waste disposal. Some of the routes of exposure are atmospheric discharge, liquid discharge, irrigation, environment, decomposition of the rain, food chains, etc. International regulations on subject of radiological safety are set by the IAEA and have a hierarchical order: fundamentals, requirements and guidelines. The International Commission of Radiological Protection and the Committee of the General Assembly of the United Nations are described in the research. The action is exposed in Cuba with regard to nuclear programs that have been realized or that are executed in relation to the control of the exposure of the public in existing applications. It mentions the centralized management of radioactive rights generated, the control of other sources of exposure, and the Red Nacional de Vigilancia Radiologica Ambiental. It also includes numerical data of studies realized on the extent of the sources of public exposure, the external doses received by the Cuban population product of environmental sources of radiation, the estimating of the doses received by the Cuban population by the incorporation of radionuclides present in the water and food. Likewise, the radioactive environmental funds; the phosphate mining; the protection and extraction of oil and the presence of radon inside the house are shown. The exposure to gamma radiation in thermal spas; the exposure to environmental sources of radiation

  12. AutoCAD 2008 and AutoCAD LT 2008 Bible

    CERN Document Server

    Finkelstein, Ellen

    2011-01-01

    "Whether you're new to AutoCAD or a veteran, you will undoubtedly find this book to be an excellent resource."-- Abhi Singh, AutoCAD Product Manager, Autodesk, Inc.Here's the book that makes AutoCAD approachableEven the people at Autodesk look to Ellen Finkelstein for AutoCAD training, so who better to teach you about AutoCAD 2008? This comprehensive guide brings veterans up to speed on AutoCAD updates and takes novices from the basics to programming in AutoLISP(r) and VBA. Every feature is covered in a logical order, and with the Quick Start chapter, you'll be creating drawings on your very f

  13. Development and evaluation of a self-cleaning custom-built auto sampler controlled by a low-cost RaspberryPi microcomputer for online enzymatic activity measurements.

    Science.gov (United States)

    Stadler, Philipp; Farnleitner, Andreas H; Zessner, Matthias

    2017-01-01

    A fully automated on-site device (SAMP-FIL) that enables water sampling with simultaneous filtration and effective cleaning procedures of the device's components was developed and field-tested. The SAMP-FIL was custom-built using commercially available components and was controlled by a RaspberryPi single-board computer operating open-source software. SAMP-FIL was designed for sample pre-treatment with minimal sample alteration to meet the requirements of on-site measurement devices that cannot handle coarse suspended solids within the measurement procedure or cycle. A highly effective cleaning procedure provides a fresh and minimally altered sample for the connected measurement device. The construction and programmed software facilitates the use of SAMP-FIL for different connected measurement devices. The SAMP-FIL sample pretreatment was tested for over one year for rapid and on-site enzymatic activity (beta-d-glucuronidase, GLUC) determination (BACTcontrol) in sediment-laden stream water. The formerly used proprietary sampling set-up was assumed to lead to significant damping of the measurement signal due to its susceptibility to clogging, debris accumulation and bio-film accumulation. The implementation of SAMP-FIL considerably increased the error-free running time and measurement accuracy of BACTcontrol devices. This paper describes how low-cost microcomputers, such as the RaspberryPi, can be used by operators to substantially improve established measuring systems via effective sampling devices. Furthermore, the results of this study highlight the importance of adequate sample pretreatment for the quality of on-site measurements. Copyright © 2016 The Authors. Published by Elsevier B.V. All rights reserved.

  14. Effectiveness of a Multidimensional Randomized Control Intervention to Reduce Quartz Exposure Among Construction Workers.

    Science.gov (United States)

    van Deurssen, Erik; Meijster, Tim; Oude Hengel, Karen M; Boessen, Ruud; Spaan, Suzanne; Tielemans, Erik; Heederik, Dick; Pronk, Anjoeka

    2015-10-01

    There is little evidence with respect to the effectiveness of intervention programs that focus on the reduction of occupational quartz exposure in the construction industry. This article evaluates the effectiveness of a multidimensional intervention which was aimed at reducing occupational quartz exposure among construction workers by increasing the use of technical control measures. Eight companies participating in the cluster randomized controlled trial were randomly allocated to the intervention (four companies) or control condition (four companies). The multidimensional intervention included engineering, organizational, and behavioural elements at both organizational and individual level. Full-shift personal quartz exposure measurements and detailed observations were conducted before and after the intervention among bricklayers, carpenters, concrete drillers, demolishers, and tuck pointers (n = 282). About 59% of these workers measured at baseline were reassessed during follow-up. Bayesian hierarchical models were used to evaluate the intervention effect on exposure levels. Concrete drillers in the intervention group used technical control measures, particularly water suppression, for a significantly greater proportion of the time spent on abrasive tasks during follow-up compared to baseline (93 versus 62%; P quartz exposure (73 versus 40% in the intervention and control group respectively; P quartz exposure among high exposed construction workers. © The Author 2015. Published by Oxford University Press on behalf of the British Occupational Hygiene Society.

  15. Trends in Teenagers' Nonopiod Substance Exposures Reported to Poison Control Centers, 2010-2015.

    Science.gov (United States)

    Wright, Brad; Mestan, Samantha; Ahrens, Monica; Bottei, Edward

    2018-05-01

    To describe current trends in nonopioid substance exposures and associated outcomes among teenagers nationwide. In this cross-sectional study, we used 2010-2015 data from the American Association of Poison Control Centers' National Poison Data System and Poisson tests to document trends in the rate of calls to poison control centers involving adolescents stratified by sex, exposures by substance category, proportion of intentional exposures, and severity of exposures. The number of calls per 1000 persons increased from 5.7 to 6.8 for teenage girls and decreased from 4.7 to 4.3 for boys. Reported exposures to prescription and over-the-counter medications and illicit street drugs increased between 24% and 73%, and reported opioid exposures decreased by 16%. Among teenage girls, intentional exposures increased from 57% to 68%, with cases increasingly managed in health care facilities and more likely to result in worse health outcomes. The increase in intentional nonopioid substance exposures among teenage girls, with serious and potentially life-threatening consequences, is a matter of serious concern. Similar trends were not observed among teenage boys. Copyright © 2017 Elsevier Inc. All rights reserved.

  16. Virtual reality exposure therapy for social anxiety disorder: a randomized controlled trial.

    Science.gov (United States)

    Anderson, Page L; Price, Matthew; Edwards, Shannan M; Obasaju, Mayowa A; Schmertz, Stefan K; Zimand, Elana; Calamaras, Martha R

    2013-10-01

    This is the first randomized trial comparing virtual reality exposure therapy to in vivo exposure for social anxiety disorder. Participants with a principal diagnosis of social anxiety disorder who identified public speaking as their primary fear (N = 97) were recruited from the community, resulting in an ethnically diverse sample (M age = 39 years) of mostly women (62%). Participants were randomly assigned to and completed 8 sessions of manualized virtual reality exposure therapy, exposure group therapy, or wait list. Standardized self-report measures were collected at pretreatment, posttreatment, and 12-month follow-up, and process measures were collected during treatment. A standardized speech task was delivered at pre- and posttreatment, and diagnostic status was reassessed at 3-month follow-up. Analysis of covariance showed that, relative to wait list, people completing either active treatment significantly improved on all but one measure (length of speech for exposure group therapy and self-reported fear of negative evaluation for virtual reality exposure therapy). At 12-month follow-up, people showed significant improvement from pretreatment on all measures. There were no differences between the active treatments on any process or outcome measure at any time, nor differences on achieving partial or full remission. Virtual reality exposure therapy is effective for treating social fears, and improvement is maintained for 1 year. Virtual reality exposure therapy is equally effective as exposure group therapy; further research with a larger sample is needed, however, to better control and statistically test differences between the treatments.

  17. Polarization imaging apparatus with auto-calibration

    Science.gov (United States)

    Zou, Yingyin Kevin; Zhao, Hongzhi; Chen, Qiushui

    2013-08-20

    A polarization imaging apparatus measures the Stokes image of a sample. The apparatus consists of an optical lens set, a first variable phase retarder (VPR) with its optical axis aligned 22.5.degree., a second variable phase retarder with its optical axis aligned 45.degree., a linear polarizer, a imaging sensor for sensing the intensity images of the sample, a controller and a computer. Two variable phase retarders were controlled independently by a computer through a controller unit which generates a sequential of voltages to control the phase retardations of the first and second variable phase retarders. A auto-calibration procedure was incorporated into the polarization imaging apparatus to correct the misalignment of first and second VPRs, as well as the half-wave voltage of the VPRs. A set of four intensity images, I.sub.0, I.sub.1, I.sub.2 and I.sub.3 of the sample were captured by imaging sensor when the phase retardations of VPRs were set at (0,0), (.pi.,0), (.pi.,.pi.) and (.pi./2,.pi.), respectively. Then four Stokes components of a Stokes image, S.sub.0, S.sub.1, S.sub.2 and S.sub.3 were calculated using the four intensity images.

  18. Polarization Imaging Apparatus with Auto-Calibration

    Science.gov (United States)

    Zou, Yingyin Kevin (Inventor); Zhao, Hongzhi (Inventor); Chen, Qiushui (Inventor)

    2013-01-01

    A polarization imaging apparatus measures the Stokes image of a sample. The apparatus consists of an optical lens set, a first variable phase retarder (VPR) with its optical axis aligned 22.5 deg, a second variable phase retarder with its optical axis aligned 45 deg, a linear polarizer, a imaging sensor for sensing the intensity images of the sample, a controller and a computer. Two variable phase retarders were controlled independently by a computer through a controller unit which generates a sequential of voltages to control the phase retardations of the first and second variable phase retarders. A auto-calibration procedure was incorporated into the polarization imaging apparatus to correct the misalignment of first and second VPRs, as well as the half-wave voltage of the VPRs. A set of four intensity images, I(sub 0), I(sub 1), I(sub 2) and I(sub 3) of the sample were captured by imaging sensor when the phase retardations of VPRs were set at (0,0), (pi,0), (pi,pi) and (pi/2,pi), respectively. Then four Stokes components of a Stokes image, S(sub 0), S(sub 1), S(sub 2) and S(sub 3) were calculated using the four intensity images.

  19. Human bromethalin exposures reported to a U.S. Statewide Poison Control System.

    Science.gov (United States)

    Huntington, Serena; Fenik, Yelena; Vohra, Rais; Geller, Richard J

    2016-03-01

    Bromethalin is an increasingly used alternative to long-acting anticoagulant and cholecalciferol rodenticides. There are few reports of human exposures, and no existing professional society guidelines on medical management of bromethalin ingestions. The aim of this retrospective data review is to characterize bromethalin exposures reported to the California Poison Control System (CPCS) between 1997 and 2014. This is an observational retrospective case review of our statewide poison control system's electronic medical records. Following Institutional Board Review and Research Committee approvals, poison center exposures related to bromethalin were extracted using substance code and free text search strategies. Case notes of bromethalin exposures were reviewed for demographic, clinical, laboratory, and outcome information; inclusion criteria for the study was single-substance, human exposure to bromethalin. There were 129 calls related to human bromethalin exposures (three cases met exclusion criteria). The age range of cases was 7 months-90 years old, with the majority of exposures (89 cases; 70.6%), occurring in children younger than 5 years of age (median age of 2 years). Most exposures occurred in the pediatric population as a result of exploratory oral exposure. One hundred and thirteen patients (89.7%) had no effects post exposure, while 10 patients (7.9%) had a minor outcome. Adverse effects were minor, self-limited, and mostly gastrointestinal upset. There were no moderate, major, or fatal effects in our study population. The approximate ingested dose, available in six cases, ranged from 0.067 mg/kg to 0.3 mg/kg (milligrams of bromethalin ingested per kilogram of body weight), and no dose-symptom threshold could be established from this series. Exposures were not confirmed through urine or serum laboratory testing. The prognosis for most accidental ingestions appears to be excellent. However, bromethalin exposures may result in a higher number of

  20. Exposure Control Indoors with Wearable Personal Exhaust Unit

    DEFF Research Database (Denmark)

    Bolashikov, Zhecho Dimitrov; Barova, Maria I.; Melikov, Arsen Krikor

    2013-01-01

    in a full-scale test room furnished as a double bed hospital room. A breathing thermal manikin with a realistic free convection flow around the body and breathing cycle was used to mimic a sick doctor. A second thermal manikin and a heated dummy were used to resemble two lying patients. The air exhaled...... engineering control method that can reduce the spread of pathogen laden air from sick occupants in densely occupied spaces, i.e. cinemas, public transportation, office buildings etc....

  1. Regulatory control of low level radiation exposure in Tanzania

    International Nuclear Information System (INIS)

    Nyanda, A.M.; Muhogora, W.E.

    1997-01-01

    In Tanzania, the radiation protection law was issued in 1983. Under this law, the National Radiation Commission is responsible for safe uses of ionizing radiation. The regulatory control of the resulting doses from the uses of radiation sources in medicine, industry, research and teaching is presented. The system of control reflects the existing interactions between the National Radiation Commission and users through the established radiation protection infrastructure. From the national dose registry data, it is found that the highest annual individual doses over 10 years ago, came from less than 5% of total monitored workers and were in the range 10 - 15 mSv y -1 . The experienced radiation levels in uncontrolled areas of potential workplaces is less than 1 μSv h -1 . The possibility for associating such low dose levels to the effectiveness of the existing regulatory dose control framework is discussed. Despite of this achievement, the need to improve further the radiation protection and safety programs is found necessary. (author)

  2. Development of a software based automatic exposure control system for use in image guided radiation therapy

    Science.gov (United States)

    Morton, Daniel R.

    Modern image guided radiation therapy involves the use of an isocentrically mounted imaging system to take radiographs of a patient's position before the start of each treatment. Image guidance helps to minimize errors associated with a patients setup, but the radiation dose received by patients from imaging must be managed to ensure no additional risks. The Varian On-Board Imager (OBI) (Varian Medical Systems, Inc., Palo Alto, CA) does not have an automatic exposure control system and therefore requires exposure factors to be manually selected. Without patient specific exposure factors, images may become saturated and require multiple unnecessary exposures. A software based automatic exposure control system has been developed to predict optimal, patient specific exposure factors. The OBI system was modelled in terms of the x-ray tube output and detector response in order to calculate the level of detector saturation for any exposure situation. Digitally reconstructed radiographs are produced via ray-tracing through the patients' volumetric datasets that are acquired for treatment planning. The ray-trace determines the attenuation of the patient and subsequent x-ray spectra incident on the imaging detector. The resulting spectra are used in the detector response model to determine the exposure levels required to minimize detector saturation. Images calculated for various phantoms showed good agreement with the images that were acquired on the OBI. Overall, regions of detector saturation were accurately predicted and the detector response for non-saturated regions in images of an anthropomorphic phantom were calculated to generally be within 5 to 10 % of the measured values. Calculations were performed on patient data and found similar results as the phantom images, with the calculated images being able to determine detector saturation with close agreement to images that were acquired during treatment. Overall, it was shown that the system model and calculation

  3. Management and control aimed at reducing potential exposure of cobalt irradiation units

    International Nuclear Information System (INIS)

    Yan Yukui

    2003-01-01

    This paper is intended to address the problems of the management and control of potential exposure of cobalt irradiation units and analyze both the current situation and the resultant accident reasons associated with irradiation units, with the necessary control measures provided to reduce potential exposure. The concepts of defense in depth and excellent engineering practice are introduced in design to provide the units with sufficient redundancy. In the course of scientific management, the qualified applicants or registers devoted, strictly and effectively, their oversight, monitoring and regulation to the irradiation units. The effective management and control are achieved through safety analysis and assessment, reasonable regulatory system and source decommissioning system. (authors)

  4. A controlled study of virtual reality exposure therapy for the fear of flying.

    Science.gov (United States)

    Rothbaum, B O; Hodges, L; Smith, S; Lee, J H; Price, L

    2000-12-01

    Fear of flying (FOF) affects an estimated 10-25% of the population. Patients with FOF (N = 49) were randomly assigned to virtual reality exposure (VRE) therapy, standard exposure (SE) therapy, or a wait-list (WL) control. Treatment consisted of 8 sessions over 6 weeks, with 4 sessions of anxiety management training followed by either exposure to a virtual airplane (VRE) or exposure to an actual airplane at the airport (SE). A posttreatment flight on a commercial airline measured participants' willingness to fly and anxiety during flight immediately after treatment. The results indicated that VRE and SE were both superior to WL, with no differences between VRE and SE. The gains observed in treatment were maintained at a 6-month follow up. By 6 months posttreatment, 93% of VRE participants and 93% of SE participants had flown. VRE therapy and SE therapy for treatment of FOF were unequivocally supported in this controlled study.

  5. Control banding tools for occupational exposure assessment of nanomaterials - Ready for use in a regulatory context?

    DEFF Research Database (Denmark)

    Liguori, Biase; Hansen, Steffen Foss; Baun, Anders

    2016-01-01

    area of concern. Therefore, a number of Control Banding (CB)-based tools have been developed in order to assess and manage the potential risks associated with occupational exposure to nanomaterials. In this paper we provide a comparative analysis of different nanomaterial-specific types of control-banding/risk...... developed for different purposes, with different application domains and inclusion criteria. The exposure assessments and derived risk levels are based on different concepts and assumptions and outputs in different formats. The use of requested input parameters for exposure assessment differ greatly among...... the tools. Therefore, direct inter-comparison and combination of the different models into a larger holistic framework is not immediately possible. Harmonization of input parameters and output could allow establishment of an exposure assessment framework with different levels of information requirements....

  6. Second auto-SCT for treatment of relapsed multiple myeloma.

    Science.gov (United States)

    Gonsalves, W I; Gertz, M A; Lacy, M Q; Dispenzieri, A; Hayman, S R; Buadi, F K; Dingli, D; Hogan, W J; Kumar, S K

    2013-04-01

    High-dose therapy and auto-SCT remain integral in the initial treatment of multiple myeloma (MM), and are increasingly being applied for management of relapsed disease. We examined the outcomes in 98 patients undergoing salvage auto-SCT (auto-SCT2) for relapsed MM after receiving an initial transplant (auto-SCT1) between 1994 and 2009. The median age at auto-SCT2 was 60 years (range: 35-74). The median time between auto-SCT1 and auto-SCT2 was 46 months (range: 10-130). Treatment-related mortality was seen in 4%. The median PFS from auto-SCT2 was 10.3 (95% confidence interval (CI): 7-14) months and the median OS from auto-SCT2 was 33 months (95% CI: 28-51). In a multivariable analysis, shorter time to progression (TTP) after auto-SCT1, not achieving a CR after auto-SCT2, higher number of treatment regimens before auto-SCT2 and a higher plasma cell labeling index at auto-SCT2 predicted for shorter PFS. However, only a shorter TTP after auto-SCT1 predicted for a shorter OS post auto-SCT2. Hence, auto-SCT2 is an effective and feasible therapeutic option for MM patients relapsing after other treatments, especially in patients who had a TTP of at least 12 months after their auto-SCT1.

  7. Prenatal cigarette exposure and infant learning stimulation as predictors of cognitive control in childhood

    OpenAIRE

    Mezzacappa, Enrico; Buckner, John C.; Earls, Felton

    2011-01-01

    Prenatal exposures to neurotoxins and postnatal parenting practices have been shown to independently predict variations in the cognitive development and emotional-behavioral well being of infants and children. We examined the independent contributions of prenatal cigarette exposure and infant learning stimulation, as well as their inter-relationships in predicting variations in the proficiency of executive attention, a core element of cognitive control and self-regulation.

  8. To describe and control exposure in nanoecotoxicology tests

    DEFF Research Database (Denmark)

    Baun, Anders

    There is an urgent need for reliable and reproducible results of ecotoxicological experiments in order to identify, rank, and classify the environmental hazards of nanomaterials. Standardized methods and guideline tests traditionally used for chemicals are today recommended for the testing....... The interpretation of the test results may further be complicated by the fact that these processes are ongoing during the testing period and may be affected by the organisms themselves. Therefore, the total concentration reported in concentration-response relationships in these tests encompass a range of possible...... alterations of the bioavailable part of the nanomaterial added. These alterations, which may be determining for the biological effects found, are difficult, if not impossible, to control in a standard test setting. This raises the question whether the results generated in standardized test systems...

  9. Development of risk-based nanomaterial groups for occupational exposure control

    Science.gov (United States)

    Kuempel, E. D.; Castranova, V.; Geraci, C. L.; Schulte, P. A.

    2012-09-01

    Given the almost limitless variety of nanomaterials, it will be virtually impossible to assess the possible occupational health hazard of each nanomaterial individually. The development of science-based hazard and risk categories for nanomaterials is needed for decision-making about exposure control practices in the workplace. A possible strategy would be to select representative (benchmark) materials from various mode of action (MOA) classes, evaluate the hazard and develop risk estimates, and then apply a systematic comparison of new nanomaterials with the benchmark materials in the same MOA class. Poorly soluble particles are used here as an example to illustrate quantitative risk assessment methods for possible benchmark particles and occupational exposure control groups, given mode of action and relative toxicity. Linking such benchmark particles to specific exposure control bands would facilitate the translation of health hazard and quantitative risk information to the development of effective exposure control practices in the workplace. A key challenge is obtaining sufficient dose-response data, based on standard testing, to systematically evaluate the nanomaterials' physical-chemical factors influencing their biological activity. Categorization processes involve both science-based analyses and default assumptions in the absence of substance-specific information. Utilizing data and information from related materials may facilitate initial determinations of exposure control systems for nanomaterials.

  10. Development of risk-based nanomaterial groups for occupational exposure control

    International Nuclear Information System (INIS)

    Kuempel, E. D.; Castranova, V.; Geraci, C. L.; Schulte, P. A.

    2012-01-01

    Given the almost limitless variety of nanomaterials, it will be virtually impossible to assess the possible occupational health hazard of each nanomaterial individually. The development of science-based hazard and risk categories for nanomaterials is needed for decision-making about exposure control practices in the workplace. A possible strategy would be to select representative (benchmark) materials from various mode of action (MOA) classes, evaluate the hazard and develop risk estimates, and then apply a systematic comparison of new nanomaterials with the benchmark materials in the same MOA class. Poorly soluble particles are used here as an example to illustrate quantitative risk assessment methods for possible benchmark particles and occupational exposure control groups, given mode of action and relative toxicity. Linking such benchmark particles to specific exposure control bands would facilitate the translation of health hazard and quantitative risk information to the development of effective exposure control practices in the workplace. A key challenge is obtaining sufficient dose–response data, based on standard testing, to systematically evaluate the nanomaterials’ physical–chemical factors influencing their biological activity. Categorization processes involve both science-based analyses and default assumptions in the absence of substance-specific information. Utilizing data and information from related materials may facilitate initial determinations of exposure control systems for nanomaterials.

  11. Exposure control practices for administering nitrous oxide: A survey of dentists, dental hygienists, and dental assistants.

    Science.gov (United States)

    Boiano, James M; Steege, Andrea L; Sweeney, Marie H

    2017-06-01

    Engineering, administrative, and work practice controls have been recommended for many years to minimize exposure to nitrous oxide during dental procedures. To better understand the extent to which these exposure controls are used, the NIOSH Health and Safety Practices Survey of Healthcare Workers was conducted among members of professional practice organizations representing dentists, dental hygienists and dental assistants. The anonymous, modular, web-based survey was completed by 284 dental professionals in private practice who administered nitrous oxide to adult and/or pediatric patients in the seven days prior to the survey. Use of primary engineering controls (i.e., nasal scavenging mask and/or local exhaust ventilation (LEV) near the patient's mouth) was nearly universal, reported by 93% and 96% of respondents who administered to adult (A) and pediatric (P) patients, respectively. However, adherence to other recommended precautionary practices were lacking to varying degrees, and were essentially no different among those administering nitrous oxide to adult or pediatric patients. Examples of work practices which increase exposure risk, expressed as percent of respondents, included: not checking nitrous oxide equipment for leaks (41% A; 48% P); starting nitrous oxide gas flow before delivery mask or airway mask was applied to patient (13% A; 12% P); and not turning off nitrous oxide gas flow before turning off oxygen flow to the patient (8% A; 7% P). Absence of standard procedures to minimize worker exposure to nitrous oxide (13% of all respondents) and not being trained on safe handling and administration of nitrous oxide (3%) were examples of breaches of administrative controls which may also increase exposure risk. Successful management of nitrous oxide emissions should include properly fitted nasal scavenging masks, supplemental LEV (when nitrous oxide levels cannot be adequately controlled using nasal masks alone), adequate general ventilation, regular

  12. MICRO AUTO GASIFICATION SYSTEM: EMISSIONS ...

    Science.gov (United States)

    A compact, CONEX-housed waste to energy unit, Micro Auto Gasification System (MAGS), was characterized for air emissions from burning of military waste types. The MAGS unit is a dual chamber gasifier with a secondary diesel-fired combustor. Eight tests were conducted with multiple waste types in a 7-day period at the Kilauea Military Camp in Hawai’i. The emissions characterized were chosen based on regulatory emissions limits as well as their ability to cause adverse health effects on humans: particulate matter (PM), mercury, heavy metals, volatile organic compounds (VOCs), polyaromatic hydrocarbons (PAHs), and polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs). Three military waste feedstock compositions reflecting the variety of wastes to be encountered in theatre were investigated: standard waste (SW), standard waste with increased plastic content (HP), standard waste without SW food components but added first strike ration (FSR) food and packaging material (termed FSR). A fourth waste was collected from the Kilauea dumpster that served the dining facility and room lodging (KMC). Limited scrubber water and solid ash residue samples were collected to obtain a preliminary characterization of these effluents/residues.Gasifying SW, HP, and KMC resulted in similar PCDD/PCDF stack concentrations, 0.26-0.27 ng TEQ/m3 at 7% O2, while FSR waste generated a notably higher stack concentration of 0.68 ng TEQ/m3 at 7% O2. The PM emission

  13. Uncertainties of exposure-related quantities in mammographic x-ray unit quality control

    International Nuclear Information System (INIS)

    Gregory, Kent J.; Pattison, John E.; Bibbo, Giovanni

    2006-01-01

    Breast screening programs operate in many countries with mammographic x-ray units subject to stringent quality control tests. These tests include the evaluation of quantities based on exposure measurements, such as half value layer, automatic exposure control reproducibility, average glandular dose, and radiation output rate. There are numerous error sources that contribute to the uncertainty of these exposure-related quantities, some of which are unique to the low energy x-ray spectrum produced by mammographic x-ray units. For each of these exposure-related quantities, the applicable error sources and their magnitudes vary, depending on the test equipment used to make the measurement, and whether or not relevant corrections have been applied. This study has identified and quantified a range of error sources that may be used to estimate the combined uncertainty of these exposure-related quantities, given the test equipment used and corrections applied. The uncertainty analysis uses methods described by the International Standards Organization's Guide to the Expression of Uncertainty in Measurement. Examples of how these error sources combine to give the uncertainty of the exposure-related quantities are presented. Using the best test equipment evaluated in this study, uncertainties of the four exposure-related quantities at the 95% confidence interval were found to be ±1.6% (half value layer), ±0.0008 (automatic exposure control reproducibility), ±2.3% (average glandular dose), and ±2.1% (radiation output rate). In some cases, using less precise test equipment or failing to apply corrections, resulted in uncertainties more than double in magnitude

  14. Auto Carrier Transporter Loading and Unloading Improvement

    National Research Council Canada - National Science Library

    Miller, Brian

    2003-01-01

    .... Any reduction in time and energy will result in a significant savings of money. The intent of this research is to develop an algorithm to solve the Auto Carrier Transport Pickup and Delivery Problem...

  15. Range-Based Auto-Focus Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Maracel Systems and Software Technologies, LLC proposes a revolutionary Range-Based Auto Focus (RBAF) system that will combine externally input range, such as might...

  16. Line Generalization and AutoCAD Map

    Directory of Open Access Journals (Sweden)

    Nada Vučetić

    2001-01-01

    Full Text Available The paper offers the results of original research made on the application of AutoCAD Map in line generalisation. The differences and similarities have been found out between the Douglas-Peucker method and the method of line simplification that is incorporated in AutoCAD Map. There have been also the inaccuracies found out in AutoCAD Map manual relating to the issues of buffer width and tolerance, and the line width before and after simplification. The paper gives recommendations about pseudo nodes dissolving. It has been noticed that AutoCAD Map simplification method is not independent of the order of points. The application of the method is illustrated by an example of coastal line of Istria.

  17. Association of GSTM1 and GSTT1 with ageing in auto repair shop workers.

    Science.gov (United States)

    Eshkoor, S A; Marashi, S J; Ismail, P; Rahman, S A; Mirinargesi, M; Adon, M Y; Devan, R V

    2012-05-21

    We evaluated the possible influence of glutathione S-transferase mu (GSTM1) and glutathione S-transferase theta (GSTT1) genes on genetic damage due to occupational exposure, which contributes to accelerate ageing. This study was conducted on 120 car auto repair workshop workers exposed to occupational hazards and 120 controls without this kind of exposure. The null and non-null genotypes of GSTM1 and GSTT1 genes were determined by multiplex PCR. Micronucleus frequency, Comet tail length and relative telomere length differences between the null and non-null genotypes of the GSTM1 gene were significantly greater in the exposed group. Lack of GSTT1 did not affect the damage biomarkers significantly (P > 0.05), while lack of GSTM1 was associated with greater susceptibility to genomic damage due to occupational exposure. It was concluded that early ageing is under the influence of these genes and the environmental and socio-demographic factors. Duration of working time was significantly associated with micronucleus frequency, Comet tail length and relative telomere length.

  18. Controlled Sonar Exposure Experiments on Cetaceans in Norwegian Waters: Overview of the 3S-Project.

    Science.gov (United States)

    Lam, Frans-Peter A; Kvadsheim, Petter H; Miller, Patrick J O; Tyack, Peter L; Ainslie, Michael A; Curé, Charlotte; Kleivane, Lars; Sivle, Lise Doksæter; van Ijsselmuide, Sander P; Visser, Fleur; von Benda-Beckmann, Alexander M; Wensveen, Paul J; Dekeling, René P A

    2016-01-01

    In mitigating the risk of sonar operations, the behavioral response of cetaceans is one of the major knowledge gaps that needs to be addressed. The 3S-Project has conducted a number of controlled exposure experiments with a realistic sonar source in Norwegian waters from 2006 to 2013. In total, the following six target species have been studied: killer, long-finned pilot, sperm, humpback, minke, and northern bottlenose whales. A total of 38 controlled sonar exposures have been conducted on these species. Responses from controlled and repeated exposure runs have been recorded using acoustic and visual observations as well as with electronic tags on the target animal. So far, the first dose-response curves as well as an overview of the scored severity of responses have been revealed. In this paper, an overview is presented of the approach for the study, including the results so far as well as the current status of the ongoing analysis.

  19. AutoCAD-To-NASTRAN Translator Program

    Science.gov (United States)

    Jones, A.

    1989-01-01

    Program facilitates creation of finite-element mathematical models from geometric entities. AutoCAD to NASTRAN translator (ACTON) computer program developed to facilitate quick generation of small finite-element mathematical models for use with NASTRAN finite-element modeling program. Reads geometric data of drawing from Data Exchange File (DXF) used in AutoCAD and other PC-based drafting programs. Written in Microsoft Quick-Basic (Version 2.0).

  20. Auto-associative nanoelectronic neural network

    Energy Technology Data Exchange (ETDEWEB)

    Nogueira, C. P. S. M.; Guimarães, J. G. [Departamento de Engenharia Elétrica - Laboratório de Dispositivos e Circuito Integrado, Universidade de Brasília, CP 4386, CEP 70904-970 Brasília DF (Brazil)

    2014-05-15

    In this paper, an auto-associative neural network using single-electron tunneling (SET) devices is proposed and simulated at low temperature. The nanoelectronic auto-associative network is able to converge to a stable state, previously stored during training. The recognition of the pattern involves decreasing the energy of the input state until it achieves a point of local minimum energy, which corresponds to one of the stored patterns.

  1. Auto-associative nanoelectronic neural network

    International Nuclear Information System (INIS)

    Nogueira, C. P. S. M.; Guimarães, J. G.

    2014-01-01

    In this paper, an auto-associative neural network using single-electron tunneling (SET) devices is proposed and simulated at low temperature. The nanoelectronic auto-associative network is able to converge to a stable state, previously stored during training. The recognition of the pattern involves decreasing the energy of the input state until it achieves a point of local minimum energy, which corresponds to one of the stored patterns

  2. Computing Mass Properties From AutoCAD

    Science.gov (United States)

    Jones, A.

    1990-01-01

    Mass properties of structures computed from data in drawings. AutoCAD to Mass Properties (ACTOMP) computer program developed to facilitate quick calculations of mass properties of structures containing many simple elements in such complex configurations as trusses or sheet-metal containers. Mathematically modeled in AutoCAD or compatible computer-aided design (CAD) system in minutes by use of three-dimensional elements. Written in Microsoft Quick-Basic (Version 2.0).

  3. MAPPING APPLICATIONS USING AutoCAD

    Directory of Open Access Journals (Sweden)

    SOARE Mihaela

    2006-12-01

    Full Text Available Although AutoCAD isn’t the most popular software used in 3D professional graphics area, it also offers the possibility to create realistic 3D representations using advanced rendering techniques. One of these techniques is the mapping one. The goal of this work is to shortly present several applications of mapping procedure provided by AutoCAD, by taking into account that there is a small quantity of documentary information related to this technique.

  4. Exposure to biomass smoke and chronic airway disease in Mexican women. A case-control study.

    Science.gov (United States)

    Pérez-Padilla, R; Regalado, J; Vedal, S; Paré, P; Chapela, R; Sansores, R; Selman, M

    1996-09-01

    A case-control study was performed in women older than 40 yr of age to evaluate the risk of cooking with traditional wood stoves for chronic bronchitis and chronic airway obstruction (CAO). The subjects were recruited from patients attending a referral chest hospital in Mexico City. We selected 127 patients with chronic bronchitis or CAO, of which 63 had chronic bronchitis alone, 23 had CAO alone (FEV1 less than 75% of predicted), and 41 had both chronic bronchitis and CAO (cases). Four control groups were selected: 83 patients with pulmonary tuberculosis, 100 patients with interstitial lung diseases, 97 patients with ear, nose and throat ailments, and 95 healthy visitors to the hospital (controls). Exposure to wood smoke, assessed as any or none, and as hour-years (years of exposure multiplied by average hours of exposure per day) was significantly higher in cases than in controls. Crude odds ratios for wood smoke exposure were 3.9 (95% CI, 2.0 to 7.6) for chronic bronchitis only, 9.7 (95% CI, 3.7 to 27) for CAO plus chronic bronchitis, and 1.8 (95% CI, 0.7 to 4.7) for CAO only. Differences in exposure to wood smoke persisted after adjusting by stratification and logistic regression for age, income, education, smoking, place of residence, and place of birth. Risk of chronic bronchitis alone and chronic bronchitis with CAO increased linearly with hour-years of cooking with a wood stove; odds ratios for exposure to more than 200 hour-years compared with nonexposed were 15.0 (95% CI, 5.6 to 40) for chronic bronchitis only and 75 (95% CI, 18 to 306) for chronic bronchitis with CAO. The findings support a causal role of domestic wood smoke exposure in chronic bronchitis and chronic airflow obstruction.

  5. AutoCAD 2014 review for certification official certification preparation

    CERN Document Server

    ASCENT center for technical knowledge

    2014-01-01

    The AutoCAD® 2014 Review for Certification book is intended for users of AutoCAD® preparing to complete the AutoCAD 2014 Certified Professional exam. This book contains a collection of relevant instructional topics, practice exercises, and review questions from the Autodesk Official Training Guides (AOTG) from ASCENT - Center for Technical Knowledge pertaining specifically to the Certified Professional exam topics and objectives. This book is intended for experienced users of AutoCAD in preparation for certification. New users of AutoCAD should refer to the AOTG training guides from ASCENT, such as AutoCAD/AutoCAD LT 2014 Fundamentals, for more comprehensive instruction.

  6. Respiratory and cardiovascular response during electronic control device (ECD exposure in law enforcement trainees

    Directory of Open Access Journals (Sweden)

    Kirsten M. VanMeenen

    2013-04-01

    Full Text Available Objective: Law enforcement represents a large population of workers who may be exposed to electronic control devices (ECDs. Little is known about the potential effect of exposure to these devices on respiration or cardiovascular response during current discharge. Methods: Participants (N=23 were trainees exposed to 5 seconds of an ECD (Taser X26® as a component of training. Trainees were asked to volitionally inhale during exposure. Respiratory recordings involved a continuous waveform recorded throughout the session including during the exposure period. Heart rate was calculated from a continuous pulse oximetry recording. Results: The exposure period resulted in the cessation of normal breathing patterns in all participants and in particular a decrease in inspiratory activity. No significant changes in heart rate during ECD exposure were found. Conclusions: This is the first study to examine breathing patterns during ECD exposure with the resolution to detect changes over this discrete period of time. In contrast to reports suggesting respiration is unaffected by ECDs, present evidence suggests that voluntary inspiration is severely compromised. There is no evidence of cardiac disruption during ECD exposure.

  7. Case-control study of bladder cancer in New Jersey. I. Occupational exposures in white males.

    Science.gov (United States)

    Schoenberg, J B; Stemhagen, A; Mogielnicki, A P; Altman, R; Abe, T; Mason, T J

    1984-05-01

    The occupational bladder cancer risk for New Jersey white males was estimated with the use of both industry-job title-based and exposure-based analyses of data from 658 incident cases and 1,258 general population controls. The overall bladder cancer risk attributable to occupational exposures was estimated as 20-22%. A wide variety of employment categories and exposures contributed to this risk. Odds ratios were significantly high for employment as garage and gas station workers and food counter workers and/or cooks and for exposure to leather, rubber, paint, printing ink, and other organic compounds. Odds ratios for textile mill workers, chemical workers, and metal workers for the a priori high-risk employment category and odds ratios for those exposed to dyes, chlorinated compounds, and rubber showed significant differences between younger and older subjects. Bladder cancer risk associated with occupational exposures was not limited to persons with initial exposures before 25 years of age. However, there was significantly decreasing risk for bladder cancer with increasing age at first exposure for chemical workers and metal workers and for the a priori high-risk materials and metals. Drivers and/or deliverymen and miscellaneous laborers had significantly increasing bladder cancer risk with increasing duration of employment.

  8. Occupational exposure to radon progeny: Importance, experience with control, regulatory approaches

    International Nuclear Information System (INIS)

    Kraus, W.; Schwedt, J.

    2002-01-01

    An overview of possible occupational exposures to enhanced natural radiation in Germany is given, based on an analysis of the German Radiological Protection Commission. So far, the most significant exposure source is radon at underground and above ground workplaces. As a result of relevant regulations, in East Germany since the 70's a systematic monitoring of exposures to radon progeny has been introduced step by step in the uranium industry, in conventional ore mining, in show caves and mines, in enterprises for securing mining areas against subsidence, in radon spas and in water works in radon affected areas. Individual exposures have been assessed. The monitoring results for the period 1975-1998 are presented. Successful protection measures leading to a significant reduction of the exposures are discussed. using workplace monitoring results and registered occupancy times. In West Germany no regulations in this area were in force. Nevertheless, voluntary measuring programmes at similar workplaces were carried out. In case of unacceptable exposures successful protection measures were implemented. At present a systematic approach to control occupational exposures to radon is laid down in the European Directive 96/29/Euratom which has to be taken over in the national legislation to come. The expected number of workplaces to be included in the radiation protection system in Germany, the recommendable way of including different workplace types taking into account appropriate reference levels, and possible approaches to a graded system of workplace and individual monitoring are discussed in detail. (author)

  9. Individual external exposures from Nevada Test Site fallout for Utah leukemia cases and controls

    International Nuclear Information System (INIS)

    Lloyd, R.D.; Gren, D.C.; Simon, S.L.; Wrenn, M.E.; Hawthorne, H.A.; Lotz, T.M.; Stevens, W.; Till, J.E.

    1990-01-01

    External gamma-ray exposures from fallout originating at the Nevada Test Site (NTS) have been assigned to 6,507 individual subjects (1,177 leukemia cases and 5,330 control subjects) who died as Utah residents between 1952 and 1981. Leukemia cases were identified, confirmed, and classified by cell type from the Utah Cancer Registry, Utah State vital records, and medical records. Residential histories were obtained from the Deceased Membership File (DMF) of the Church of Jesus Christ of Latter-day Saints (LDS), supplemented by information from the LDS Church Census Records that were taken in 1950, 1955, and 1960-62. Control subjects were selected randomly within age strata from the DMF and were frequency-matched to the cases by age at death and for sex. Individual radiation exposures were assigned as a function of residence location and time interval for each residence during the fallout period (1951-1958) using geographic exposure data taken from the literature. Temporal distribution of exposure for subjects who resided in more than one locality or who were born or died during the fallout period was determined from data of other investigators. Calculated gamma-ray exposures for each place of residence were summed for each subject to yield the exposure to fallout from the NTS

  10. Administrative and research needs associated with the control of occupational exposures in commercial nuclear power plants

    International Nuclear Information System (INIS)

    Moeller, D.W.

    1980-01-01

    This review of occupational exposures in commercial nuclear power plants in the United States of America has revealed that, although many problem areas are being adequately addressed, there is a need for additional work. Areas relative to exposure evaluation that need attention include better data collection and analysis as to when and where exposures occur, improved information on exposures from internally deposited radionuclides, improved techniques for monitoring occupational neutron exposures, and an upgrading in quality control procedures in the manufacture, calibration, use and maintenance of monitoring instruments. Areas relative to exposure control that need attention include the development of additional design and manufacturing approaches for preventing the production and build-up of key radionuclides within reactor cooling systems, the development and testing of techniques for removing those radionuclides that do accumulate in such systems, the application of risk/benefit assessments to procedures for the maintenance, repair, modification, replacement and disposal of major nuclear power plant components, such as steam generators, and the development of design features to facilitate the decommissioning of nuclear power plants. Professional radiation workers also have to be aware of the impact that the proposed major reductions in occupational dose limits would have on their operations. This impact is compounded by the fact that the number of people receiving graduate education in radiation protection in the USA is decreasing. (author)

  11. Strategies to determine and control the contributions of indoor air pollution to total inhalation exposure (STRATEX)

    DEFF Research Database (Denmark)

    Cochet, C.; Fernandes, E.O.; Jantunen, M.

    ECA-IAQ (European Collaborative Action, Urban Air, Indoor Environment and Human Exposure), 2006. Strategies to determine and control the contributions of indoor air pollution to total inhalation exposure (STRATEX), Report No 25. EUR 22503 EN. Luxembourg: Office for Official Publications...... of the European Communities It is now well established that indoor air pollution contributes significantly to the global burden of disease of the population. Therefore, the knowledge of this contribution is essential in view of risk assessment and management. The ECA STRATEX report collates the respective...... information and describes the strategies to determine population exposure to indoor air pollutants. Its major goal is to emphasise the importance of the contribution of indoor air to total air exposure. Taking this contribution into account is a prerequisite for sound risk assessment of air pollution...

  12. Concept for the controlled plane wave exposure for animal experiments using a parabolic reflector

    Science.gov (United States)

    Tejero, S.; Schelkshorn, S.; Detlefsen, J.

    2005-05-01

    In this paper a low-cost concept for the controlled RF plane wave exposure for in vivo experiments is presented. The exposure setup is based on the use of a parabolic reflector to convert the incident spherical wavefront emanating from the primary source into a plane wave. The employed paraboloid is a common prime focus paraboloid used in satellite-TV links. The main problems of the focussed approach are identified and a solution based on a defocussed system is introduced. It results in a compact, cost-effective and still power-efficient setup for the RF exposure at microwave frequencies. Simulation results show a very good performance of the concept achieving a quasi-plane wave incident on the animals with minimum variations of the exposure dose.

  13. A simple control for sediment-toxicity exposures using the amphipod, Hyalella azteca

    Science.gov (United States)

    Lasier, Pete; Urich, Matthew L.

    2014-01-01

    Sediment-toxicity exposures comparing survival and growth of the freshwater amphipod, Hyalella azteca, are often components of aquatic-habitat assessments. Standardized exposure methods have been established and require evaluations for quality assurance. Test acceptability using performance-based criteria can be determined from exposures to control sediments, which are collected from the environment or formulated from commercially available components. Amending sand with leached alfalfa solids provided a simple formulated sediment that elicited consistently acceptable survival and growth in 28-day exposures with and without a daily feeding regime. A procedure is described for preparing the sediment along with results from comparisons among sand, amended sand, and field-collected sediments that incorporated three feeding regimes.

  14. Analysis on the workspace of palletizing robot based on AutoCAD

    Science.gov (United States)

    Li, Jin-quan; Zhang, Rui; Guan, Qi; Cui, Fang; Chen, Kuan

    2017-10-01

    In this paper, a four-degree-of-freedom articulated palletizing robot is used as the object of research. Based on the analysis of the overall configuration of the robot, the kinematic mathematical model is established by D-H method to figure out the workspace of the robot. In order to meet the needs of design and analysis, using AutoCAD secondary development technology and AutoLisp language to develop AutoCAD-based 2D and 3D workspace simulation interface program of palletizing robot. At last, using AutoCAD plugin, the influence of structural parameters on the shape and position of the working space is analyzed when the structure parameters of the robot are changed separately. This study laid the foundation for the design, control and planning of palletizing robots.

  15. Visual Auto-landing of an Autonomous Aircraft

    OpenAIRE

    Rives, Patrick; Azinheira, José Raul

    2002-01-01

    This report is the summary of work done in the CIMAR project of collaboration between IST (Lisboa) and the Icare Project (INRIA Sophia Antipolis) for vision-based control applied to an autonomous aircraft. An unified modeling framework is defined and the vision-based auto-landing of the UAV model is analyzed, based on the classical alternative between position-based and image-based visual control. The controller design is adapted for both approaches and simulations results are presented in or...

  16. High Seroprevalence of Leptospira Exposure in Meat Workers in Northern Mexico: A Case-Control Study

    Science.gov (United States)

    Alvarado-Esquivel, Cosme; Hernandez-Tinoco, Jesus; Sanchez-Anguiano, Luis Francisco; Ramos-Nevarez, Agar; Cerrillo-Soto, Sandra Margarita; Saenz-Soto, Leandro; Martinez-Ramirez, Lucio

    2016-01-01

    Background The seroepidemiology of Leptospira infection in workers occupationally exposed to raw meat has been poorly studied. This work aimed to determine the association between Leptospira exposure and the occupation of meat worker, and to determine the seroprevalence association with socio-demographic, work, clinical and behavioral characteristics of the meat workers studied. Methods We performed a case-control study in 124 meat workers and 124 age- and gender-matched control subjects in Durango City, Mexico. Sera of cases and controls were analyzed for anti-Leptospira IgG antibodies using a commercially available enzyme immunoassay. Data of meat workers were obtained with the aid of a questionnaire. The association of Leptospira exposure with the characteristics of meat workers was analyzed by bivariate and multivariate analyses. Results Anti-Leptospira IgG antibodies were found in 22 (17.7%) of 124 meat workers and in eight (6.5%) of 124 controls (OR = 3.12; 95% CI: 1.33 - 7.33; P = 0.006). Seroprevalence of Leptospira infection was similar between male butchers (17.6%) and female butchers (18.2%) (P = 1.00). Multivariate analysis of socio-demographic, work and behavioral variables showed that Leptospira exposure was associated with duration in the activity, rural residence, and consumption of snake meat and unwashed raw fruits. Conclusions This is the first case-control study of the association of Leptospira exposure with the occupation of meat worker. Results indicate that meat workers represent a risk group for Leptospira exposure. Risk factors for Leptospira exposure found in this study may help in the design of optimal preventive measures against Leptospira infection. PMID:26858797

  17. Neospora caninum versus Brucella spp. exposure among dairy cattle in Ethiopia: a case control study.

    Science.gov (United States)

    Asmare, Kassahun

    2014-08-01

    This case-control study aimed at assessing the relative association of Neospora caninum and Brucella species exposure with reproductive disorders. The study was carried out between October 2011 and June 2012 on 731 dairy cows sampled from 150 dairy farms in selected 17 conurbations of Ethiopia. Two hundred sixty-six of the cows were categorized as cases based on their history of abortion or stillbirth while the remaining 465 were controls. The presence of antibody to N. caninum was screened using indirect ELISA, while Brucella spp. exposure was assayed serially using Rose Bengal Plate Test and Complement Fixation Test. Exposure to N. caninum was more frequently observed among cases (23.8%) than controls (12.7%), while no significant difference (p > 0.05) was noted for Brucella exposure between the two groups. Moreover, the proportion of cows with disorders like retention of fetal membrane, endometritis and increased inter-calving period were significantly higher (p Brucella spp. exposure. However, neither N. caninum nor Brucella spp. could explain the majority (73.2%) of the reported abortions and stillbirths in cattle. Hence, this observation underscores the need for more intensive investigation on the identification of causes of the aforementioned disorders in dairy cattle of Ethiopia.

  18. Serum folate levels after UVA exposure: a two-group parallel randomised controlled trial

    Directory of Open Access Journals (Sweden)

    Altmeyer Peter

    2001-11-01

    Full Text Available Abstract Background Photodegradation of certain vitamins such as riboflavins, carotinoids, tocopherol, and folate has been well-documented. Previous observations suggest that ultraviolet (UV radiation may cause folate deficiency. This is of great importance since folate deficiency is also known to be linked with the development of neural tube defects. To investigate the influence of UVA radiation on serum folate levels in vivo, we conducted a two-group randomised controlled trial on healthy subjects. Material and methods Twenty-four healthy volunteers with skin type II were enrolled into the study. Eight volunteers of the study population were randomly assigned to the control group. UVA irradiation was administered with an air-conditioned sunbed. Blood samples were taken from all volunteers at baseline (T1, 30 min after the first UVA exposure (T2, and at the end of the study 24 h after the sixth UV exposure (T3. The volunteers had two UVA exposures weekly within three weeks (cumulative UVA dose: 96 J/cm2. Volunteers of the control group had no UVA exposures. Serum folate was analysed with an automated immunoassay system. Results At all times of blood collection the differences between serum folate levels were insignificant (P > 0.05, except of the non-exposed controls at T2 (P 0.05. Conclusions Our data suggest that both single and serial UVA exposures do not significantly influence serum folate levels of healthy subjects. Therefore, neural tube defects claimed to occur after periconceptual UVA exposure are probably not due to UVA induced folate deficiency.

  19. Adaptive image content-based exposure control for scanning applications in radiography

    NARCIS (Netherlands)

    Schulerud, H.; Thielemann, J.; Kirkhus, T.; Kaspersen, K.; Østby, J.M.; Metaxas, M.G.; Royle, G.J.; Griffiths, J.; Cook, E.; Esbrand, C.; Pani, S.; Venanzi, C.; van der Stelt, P.F.; Li, G.; Turchetta, R.; Fant, A.; Theodoridis, S.; Georgiou, H.; Hall, G.; Noy, M.; Jones, J.; Leaver, J.; Triantis, F.; Asimidis, A.; Manthos, N.; Longo, R.; Bergamaschi, A.; Speller, R.D.

    2007-01-01

    I-ImaS (Intelligent Imaging Sensors) is a European project which has designed and developed a new adaptive X-ray imaging system using on-line exposure control, to create locally optimized images. The I-ImaS system allows for real-time image analysis during acquisition, thus enabling real-time

  20. Enforcement of radiation safety standards and experience in the regulatory control of exposures

    International Nuclear Information System (INIS)

    Krishnamurthi, T.N.

    1997-01-01

    Regulatory provisions for radiation protection and their enforcement in India are discussed in this paper. The rules and regulations framed for radiation safety cover all the nuclear fuel cycle activities as well as the application of radiation sources in industrial, medical and research institutions. The enforcement aspects and experience in the control of exposures are presented. (author)

  1. On the validity of the case-time-control design for autocorrelated exposure histories

    DEFF Research Database (Denmark)

    Jensen, Aksel Karl Georg; Gerds, Thomas Alexander; Weeke, Peter

    2014-01-01

    review the mathematical assumptions underlying the case-time-control design and examine sensitivity to deviations from the assumed independence of within-individual exposure history. Results from simulating various scenarios suggest that the design is quite robust to deviations from this model assumption...

  2. A VIRTUAL REALITY EXPOSURE THERAPY FOR PTSD PATIENTS CONTROLLED BY A FUZZY LOGIC SYSTEM

    Directory of Open Access Journals (Sweden)

    Rosa Maria Esteves Moreira da Costa

    2014-06-01

    Full Text Available This paper describes the main characteristics of two integrated systems that explore Virtual Reality technology and Fuzzy Logic to support and to control the assessment of people with Post-Traumatic Stress Disorder during the Virtual Reality Exposure Therapy. The integration of different technologies, the development methodology and the test procedures are described throughout the paper.

  3. Renal effects of acute exposure to toluene. A controlled clinical trial

    DEFF Research Database (Denmark)

    Nielsen, H K; Krusell, Lars Romer; Bælum, Jesper

    1985-01-01

    Urinary excretion rates of beta 2-microglobulin and albumin were measured in 43 male printing trade workers and 43 age-matched male controls before and during exposure to toluene, 382 mg/m3, for 6 1/2 hours in a climate chamber. There were no significant changes in renal excretion rates of albumin...

  4. Exposure to virtual social interactions in the treatment of social anxiety disorder: A randomized controlled trial

    NARCIS (Netherlands)

    Kampmann, I.L.; Emmelkamp, P.M.G.; Hartanto, D.; Brinkman, W.P.; Zijlstra, B.J.H.; Morina, N.

    2016-01-01

    This randomized controlled trial investigated the efficacy of a stand-alone virtual reality exposure intervention comprising verbal interaction with virtual humans to target heterogeneous social fears in participants with social anxiety disorder. Sixty participants (Mage = 36.9 years; 63.3% women)

  5. Auto-correlograms and auto-regressive models of trace metal distributions in Cochin backwaters

    Digital Repository Service at National Institute of Oceanography (India)

    Jayalakshmy, K.V.; Sankaranarayanan, V.N.

    ,2 and 3 and for Zn at stations 1 and 4. The stability in time for the concentration profiles increases as Fe Mn Ni Cu Co. The fraction of variability in the variables obtained by the auto-regressive model of order 1 ranges from 20 to 50%. Auto-regressive...

  6. Self-Programmed Counseling and Self-Programmed Control Manual. A Guide to Self-Image Development with Emphasis on the Chicano Student. Student's Guide = Manual de Sistema de Consejo Auto Programado y Control Auto Programado. Una Guia Para el Desarrollo de La Imagen Propia Con un Enfasis en el Estudiante Chicano.

    Science.gov (United States)

    Mireles, S. Raymond

    Self-Programmed Counseling, the instructor's guidance, and Self-Programmed Control (SPC), the student's response, was initially developed by Title III Project USTED (United Students and Teachers for Educational Development) for Mexican American college students on academic probation to use on a non-credit, special group counseling basis. As part…

  7. Effects of prenatal substance exposure on neurocognitive correlates of inhibitory control success and failure.

    Science.gov (United States)

    Roos, Leslie E; Beauchamp, Kathryn G; Pears, Katherine C; Fisher, Philip A; Berkman, Elliot T; Capaldi, Deborah

    2017-01-01

    Adolescents with prenatal substance (drug and alcohol) exposure exhibit inhibitory control (IC) deficits and aberrations in associated neural function. Nearly all research to date examines exposure to individual substances, and a minimal amount is known about the effects of heterogeneous exposure-which is more representative of population exposure levels. Using functional magnetic resonance imaging (fMRI), we investigated IC (Go/NoGo) in heterogeneously exposed (n = 7) vs. control (n = 7) at-risk adolescents (ages 13-17). The fMRI results indicated multiple IC processing differences consistent with a more immature developmental profile for exposed adolescents (Exposed  >  Nonexposed: NoGo > Go: right ventrolateral prefrontal cortex, right cuneus, and left inferior parietal lobe; NoGo > false alarm: occipital lobe; Go > false alarm: right anterior prefrontal cortex). Simple effects suggest exposed adolescents exhibited exaggerated correct trial but decreased incorrect trial activation. Results provide initial evidence that prenatal exposure across substances creates similar patterns of atypical brain activation to IC success and failure.

  8. Residential traffic noise exposure and vestibular schwannoma - a Danish case-control study.

    Science.gov (United States)

    Roswall, Nina; Stangerup, Sven-Eric; Cayé-Thomasen, Per; Schüz, Joachim; Johansen, Christoffer; Jensen, Steen Solvang; Raaschou-Nielsen, Ole; Sørensen, Mette

    2017-10-01

    Few risk factors for sporadic vestibular schwannoma (VS) are known. Several studies have proposed an increased risk with occupational noise exposure, whereas no studies have investigated residential traffic noise exposure as a risk factor. The present study investigated if residential traffic noise was associated with vestibular schwannoma in a large, population-based Danish case-control study. We identified 1454 VS cases, age above 30 years at diagnosis, between 1990 and 2007. For each case, we selected two random population controls, matched on sex and year of birth. Road and railway traffic noise at the residence was calculated for all present and historical addresses between 1987 and index date. Associations between traffic noise and risk for VS were estimated using conditional logistic regression, adjusted for education, disposable personal income, cohabitation status, railway noise exposure, municipal population density, and municipal income. A two-year time-weighted mean road traffic noise exposure was associated with an adjusted odds ratio of 0.92 (0.82-1.03) for developing VS, per 10 dB increment. There was no clear trend in categorical analyses. Similarly, linear and categorical analyses of residential railway noise did not suggest an association. We found no interaction with demographics, year of diagnosis, individual and municipal socioeconomic variables, and railway noise exposure. The results did not differ by tumor side, spread or size. The present study does not suggest an association between residential traffic noise and VS.

  9. AutoCAD 2012 and AutoCAD LT 2012 Bible

    CERN Document Server

    Finkelstein, Ellen

    2011-01-01

    The latest version of this perennial favorite, in-depth, reference-tutorial This top-selling book has been updated by AutoCAD guru and author Ellen Finkelstein to provide you with the very latest coverage of both AutoCAD 2012 and AutoCAD LT 2012. It begins with a Quick Start tutorial, so you start creating right away. From there, the book covers so much in-depth material on AutoCAD that it is said that even Autodesk employees keep this comprehensive book at their desks. A DVD is included that features before-and-after drawings of all the tutorials and plenty of great examples from AutoCAD prof

  10. Pediatric Exposures to Topical Benzocaine Preparations Reported to a Statewide Poison Control System

    Directory of Open Access Journals (Sweden)

    Rais Vohra

    2017-07-01

    Full Text Available Introduction: Topical benzocaine is a local anesthetic commonly used to relieve pain caused by teething, periodontal irritation, burns, wounds, and insect bites. Oral preparations may contain benzocaine concentrations ranging from 7.5% to 20%. Pediatric exposure to such large concentrations may result in methemoglobinemia and secondarily cause anemia, cyanosis, and hypoxia. Methods: This is a retrospective study of exposures reported to a statewide poison control system. The electronic health records were queried for pediatric exposures to topical benzocaine treated at a healthcare facility from 2004 to 2014. Cases of benzocaine exposure were reviewed for demographic and clinical information, and descriptive statistical analysis was performed. Results: The query resulted in 157 cases; 58 were excluded due to co-ingestants, or miscoding of non-benzocaine exposures. Children four years of age and younger represented the majority of cases (93% with a median age of 1 year. There were 88 cases of accidental/ exploratory exposure, while 6 cases resulted from therapeutic application or error, 4 cases from adverse reactions, and 1 case from an unknown cause. Asymptomatic children accounted for 75.5% of cases, but major clinical effects were observed in 5 patients. Those with serious effects were exposed to a range of benzocaine concentrations (7.5–20%, with 4 cases reporting methemoglobin levels between 20.2%–55%. Methylene blue was administered in 4 of the cases exhibiting major effects. Conclusion: The majority of exposures were accidental ingestions by young children. Most exposures resulted in minor to no effects. However, some patients required treatment with methylene blue and admission to a critical care unit. Therapeutic application by parents or caregivers may lead to adverse effects from these commonly available products.

  11. Pesticide Exposure and Head and Neck Cancers: A Case-Control Study in an Agricultural Region

    Directory of Open Access Journals (Sweden)

    Maryam Amizadeh

    2017-09-01

    Full Text Available Introduction: Causes of head and neck cancers (HNCs are multifactorial, and few studies have investigated the association between chemical exposure and HNCs. The objective of this study was to investigate associations between HNCs, agricultural occupations, and pesticide exposure. The potential for the accumulation of pesticides in the adipose tissue of patients was also investigated.   Materials and Methods: A structured questionnaire was used to collect information on demographics, occupation, and exposure to pesticides in a hospital-based case-control study. Pesticide residue in the adipose tissue of the neck in both cases and controls was also monitored via gas chromatography–mass spectroscopy.   Results: Thirty-one HNC cases were included in this study as well as 32 gender-, age-, and smoking-matched controls. An agricultural occupation was associated with HNC (odds ratio [OR], 3.26; 95% confidence interval [CI], 1.13–9.43 after controlling for age, sex, and smoking. Pesticide exposure was associated with total HNC cases (OR, 7.45; 95% CI, 1.78–3.07 and larynx cancer (OR, 9.33; 95% CI, 1.65–52.68. A dose-response pattern was observed for HNC cases (P=0.06 and larynx cancer (P=0.01. In tracing the pesticide residue, five chlorinated pesticides, namely dichlorodiphenyltrichloroethane (DDT, dichlorodipheny-ldichloroethane (DDD, dichlorodiphenyldichloroethylene (DDE, dieldrin, and lindane, were identified in the adipose tissue. Chlorinated pesticide detection was significantly associated with HNC (OR, 3.91; 95% CI 0.9–0.16.9.   Conclusion: HNCs were found to be associated with pesticide exposure after controlling for confounders. A high education level was identified as a modifying factor decreasing the risk of HNCs. Further studies with larger number of subjects are recommended to assess these relationships in greater detail.

  12. Etude de l'auto-adaptivité du filtre actif parallèle aux variations de la ...

    African Journals Online (AJOL)

    Pour assurer l'auto-additivité du filtre aux variations de la charge, deux schémas de régulation à base du régulateur P sont proposés, l'un pour la tension continue et ... To ensure filter auto-adaptivity, two control schemes based on P controller are proposed; one for dc voltage control and the second for the injected current ...

  13. Leptospira Exposure and Waste Pickers: A Case-Control Seroprevalence Study in Durango, Mexico.

    Science.gov (United States)

    Alvarado-Esquivel, Cosme; Hernandez-Tinoco, Jesus; Sanchez-Anguiano, Luis Francisco; Ramos-Nevarez, Agar; Cerrillo-Soto, Sandra Margarita; Guido-Arreola, Carlos Alberto

    2015-08-01

    Infection with Leptospira may occur by contact with Leptospira-infected animals. Waste pickers are in contact with rodents and dogs while picking in the garbage. Whether waste pickers are at risk for Leptospira infection is largely unknown. This study was aimed to determine the association of Leptospira IgG seroprevalence with the occupation of waste picking, and to determine the epidemiological characteristics of the waste pickers with Leptospira exposure. Through a case-control study, we determined the seroprevalence of anti-Leptospira IgG antibodies in 90 waste pickers and 90 age- and gender-matched control subjects in Durango City, Mexico using an enzyme immunoassay. Data were analyzed by bivariate and multivariate analyses. The prevalence of anti-Leptospira IgG antibodies was similar in waste pickers (4/90: 4.4%) to that in control subjects (5/90: 5.6%) (P = 1.00). Bivariate analysis showed that Leptospira exposure in waste pickers was associated with increasing age (P = 0.009), no education (P = 0.008), and consumption of rat meat (P = 0.04). However, these associations were no longer found by multivariate analysis. Leptospira exposure in waste pickers was not associated with health status, duration in the activity, wearing hand gloves and facemasks, history of injuries with sharp material of the garbage, or contact with animals or soil. This is the first study about Leptospira exposure in waste pickers. Results suggest that waste pickers are not at increasing risk for Leptospira exposure in Durango City, Mexico. Further research with a larger sample size to elucidate the association of Leptospira exposure with waste picking activity is needed.

  14. Case-control study of congenital malformations and occupational exposure to low-level ionizing radiation

    International Nuclear Information System (INIS)

    Sever, L.E.; Gilbert, E.S.; Hessol, N.A.; McIntyre, J.M.

    1988-01-01

    In a case-control study, the authors investigated the association of parental occupational exposure to low-level external whole-body penetrating ionizing radiation and risk of congenital malformations in their offspring. Cases and controls were ascertained from births in two counties in southeastern Washington State, where the Hanford Site has been a major employer. A unique feature of this study was the linking of quantitative individual measurement of external whole-body penetrating ionizing radiation exposure of employees at the Hanford Site, using personal dosimeters, and the disease outcome, congenital malformations. The study population included 672 malformation cases and 977 matched controls from births occurring from 1957 through 1980. Twelve specific malformation types were analyzed for evidence of association with employment of the parents at Hanford and with occupational exposure to ionizing radiation. Two defects, congenital dislocation of the hip and tracheoesophageal fistula, showed statistically significant associations with employment of the parents at Hanford, but not with parental radiation exposure. Neural tube defects showed a significant association with parental preconception exposure, on the basis of a small number of cases. Eleven other defects, including Down syndrome, for which an association with radiation was considered most likely, showed no evidence of such an association. When all malformations were analyzed as a group, there was no evidence of an association with employment of the parents at Hanford, but the relation of parental exposure to radiation before conception was in the positive direction (one-tailed p value between 0.05 and 0.10). Given the number of statistical tests conducted, some or all of the observed positive correlations are likely to represent false positive findings. 30 references

  15. Leptospira Exposure and Waste Pickers: A Case-Control Seroprevalence Study in Durango, Mexico

    Science.gov (United States)

    Alvarado-Esquivel, Cosme; Hernandez-Tinoco, Jesus; Sanchez-Anguiano, Luis Francisco; Ramos-Nevarez, Agar; Cerrillo-Soto, Sandra Margarita; Guido-Arreola, Carlos Alberto

    2015-01-01

    Background Infection with Leptospira may occur by contact with Leptospira-infected animals. Waste pickers are in contact with rodents and dogs while picking in the garbage. Whether waste pickers are at risk for Leptospira infection is largely unknown. This study was aimed to determine the association of Leptospira IgG seroprevalence with the occupation of waste picking, and to determine the epidemiological characteristics of the waste pickers with Leptospira exposure. Methods Through a case-control study, we determined the seroprevalence of anti-Leptospira IgG antibodies in 90 waste pickers and 90 age- and gender-matched control subjects in Durango City, Mexico using an enzyme immunoassay. Data were analyzed by bivariate and multivariate analyses. Results The prevalence of anti-Leptospira IgG antibodies was similar in waste pickers (4/90: 4.4%) to that in control subjects (5/90: 5.6%) (P = 1.00). Bivariate analysis showed that Leptospira exposure in waste pickers was associated with increasing age (P = 0.009), no education (P = 0.008), and consumption of rat meat (P = 0.04). However, these associations were no longer found by multivariate analysis. Leptospira exposure in waste pickers was not associated with health status, duration in the activity, wearing hand gloves and facemasks, history of injuries with sharp material of the garbage, or contact with animals or soil. Conclusions This is the first study about Leptospira exposure in waste pickers. Results suggest that waste pickers are not at increasing risk for Leptospira exposure in Durango City, Mexico. Further research with a larger sample size to elucidate the association of Leptospira exposure with waste picking activity is needed. PMID:26124911

  16. [Clinical overview of auto-inflammatory diseases].

    Science.gov (United States)

    Georgin-Lavialle, S; Rodrigues, F; Hentgen, V; Fayand, A; Quartier, P; Bader-Meunier, B; Bachmeyer, C; Savey, L; Louvrier, C; Sarrabay, G; Melki, I; Belot, A; Koné-Paut, I; Grateau, G

    2018-04-01

    Monogenic auto-inflammatory diseases are characterized by genetic abnormalities coding for proteins involved in innate immunity. They were initially described in mirror with auto-immune diseases because of the absence of circulating autoantibodies. Their main feature is the presence of peripheral blood inflammation in crisis without infection. The best-known auto-inflammatory diseases are mediated by interleukines that consisted in the 4 following diseases familial Mediterranean fever, cryopyrinopathies, TNFRSF1A-related intermittent fever, and mevalonate kinase deficiency. Since 10 years, many other diseases have been discovered, especially thanks to the progress in genetics. In this review, we propose the actual panorama of the main known auto-inflammatory diseases. Some of them are recurrent fevers with crisis and remission; some others evaluate more chronically; some are associated with immunodeficiency. From a physiopathological point of view, we can separate diseases mediated by interleukine-1 and diseases mediated by interferon. Then some polygenic inflammatory diseases will be shortly described: Still disease, Schnitzler syndrome, aseptic abscesses syndrome. The diagnosis of auto-inflammatory disease is largely based on anamnesis, the presence of peripheral inflammation during attacks and genetic analysis, which are more and more performant. Copyright © 2018 Société Nationale Française de Médecine Interne (SNFMI). Published by Elsevier SAS. All rights reserved.

  17. Ayahuasca Exposure: Descriptive Analysis of Calls to US Poison Control Centers from 2005 to 2015.

    Science.gov (United States)

    Heise, C William; Brooks, Daniel E

    2017-09-01

    Ayahuasca is a hallucinogenic plant preparation which usually contains the vine Banisteriopsis caapi and the shrub Psychotria viridis. This tea originates from the Amazon Basin where it is used in religious ceremonies. Because interest in these religious groups spreading as well as awareness of use of ayahuasca for therapeutic and recreational purposes, its use is increasing. Banisteriopsis caapi is rich in β-carbolines, especially harmine, tetrahydroharmine and harmaline, which have monoamine oxidase inhibiting (MAOI) activity. Psychotria viridis contains the 5HT2A/2C/1A receptor agonist hallucinogen N,N-dimethyltryptamine (DMT). Usual desired effects include hallucination, dissociation, mood alteration and perception change. Undesired findings previously reported are nausea, vomiting, hypertension, and tachycardia. All human exposure calls reported to the American Association of Poison Controls Centers' (AAPCC) National Poison Data System (NPDS) between September 1, 2005 and September 1, 2015 were reviewed. Cases were filtered for specific plant derived ayahuasca-related product codes. Abstracted data included the following: case age and gender, exposure reason, exposure route, clinical manifestations, treatments given, medical outcomes and fatality. Five hundred and thirty-eight exposures to ayahuasca botanical products were reported. The majority of the calls to poison control centers came from healthcare facilities (83%). The most common route of exposure was ingestion. Most cases were men (437, 81%, 95% CI 77.7% - 84.3%). The median age was 21 (IQR 18-29). Most exposures were acute. Three hundred thirty-seven (63%) were reported to have a major or moderate clinical effect. The most common clinical manifestations reported were hallucinations (35%), tachycardia (34%), agitation (34%), hypertension (16%), mydriasis (13%) and vomiting (6%). Benzodiazepines were commonly given (30%). There were 28 cases in the series who required endotracheal intubation (5

  18. Assessment of heavy metal contamination, levels in topsoil at selected auto-workshops in Accra, Ghana

    International Nuclear Information System (INIS)

    Ziblim, M. Y.

    2015-07-01

    The research was conducted to assess the levels of contamination of heavy metals in the topsoil at selected auto-workshops in Accra to determine the anthropogenic and crustal contributions and the human heath risk associated with them. Soil samples collected from four auto-workshops were analysed using Atomic Absorption Spectrometer. Eleven (11) elements: Co, Fe, Cu, Mn, Cr, As, Hg, Zn, Pb, Ni, and Cd were identified in each sample collected from the auto-workshops. Pollution indices; contamintion factor (Cf) index of geoaccumulation (Igeo) and pollution load index (PLI) were used to assess the contamination levels. It revealed the extent of contamination at the auto-workshops for most of the elements which range from low to considerate contamintion. Lead (Pb) recorded the greatest contamination levels at the auto-electrical location. The results from the index of geoccumulation showed no pollution to highly pollution indicting high variations of pollution levels at different locations. The results of the PLI in almost all locations ranged from moderately to extremely polluted. Noncancer effect on children and adults due to exposure to the topsoil were also estimated with some selected metal elements. The hazard quotient (HQ) evaluation, showed ingestion to be the route of exposure to soil dust that results in a higher risk for heavy metals, followed by dermal contact. The effect due to inhalation of resuspended dust particles through the mouth and nose is relatively low. It was observed that, the auto-workshops are generally polluted with heavy metals and therefore posing ill-health effect to the humans and the environment. (au)

  19. An evaluation of retrofit engineering control interventions to reduce perchloroethylene exposures in commercial dry-cleaning shops.

    Science.gov (United States)

    Earnest, G Scott; Ewers, Lynda M; Ruder, Avima M; Petersen, Martin R; Kovein, Ronald J

    2002-02-01

    Real-time monitoring was used to evaluate the ability of engineering control devices retrofitted on two existing dry-cleaning machines to reduce worker exposures to perchloroethylene. In one dry-cleaning shop, a refrigerated condenser was installed on a machine that had a water-cooled condenser to reduce the air temperature, improve vapor recovery, and lower exposures. In a second shop, a carbon adsorber was retrofitted on a machine to adsorb residual perchloroethylene not collected by the existing refrigerated condenser to improve vapor recovery and reduce exposures. Both controls were successful at reducing the perchloroethylene exposures of the dry-cleaning machine operator. Real-time monitoring was performed to evaluate how the engineering controls affected exposures during loading and unloading the dry-cleaning machine, a task generally considered to account for the highest exposures. The real-time monitoring showed that dramatic reductions occurred in exposures during loading and unloading of the dry-cleaning machine due to the engineering controls. Peak operator exposures during loading and unloading were reduced by 60 percent in the shop that had a refrigerated condenser installed on the dry-cleaning machine and 92 percent in the shop that had a carbon adsorber installed. Although loading and unloading exposures were dramatically reduced, drops in full-shift time-weighted average (TWA) exposures were less dramatic. TWA exposures to perchloroethylene, as measured by conventional air sampling, showed smaller reductions in operator exposures of 28 percent or less. Differences between exposure results from real-time and conventional air sampling very likely resulted from other uncontrolled sources of exposure, differences in shop general ventilation before and after the control was installed, relatively small sample sizes, and experimental variability inherent in field research. Although there were some difficulties and complications with installation and

  20. AutoCAD platform customization user interface and beyond

    CERN Document Server

    Ambrosius, Lee

    2014-01-01

    Make AutoCAD your own with powerful personalization options Options for AutoCAD customization are typically the domain of administrators, but savvy users can perform their own customizations to personalize AutoCAD. Until recently, most users never thought to customize the AutoCAD platform to meet their specific needs, instead leaving it to administrators. If you are an AutoCAD user who wants to ramp up personalization options in your favorite software, AutoCAD Platform Customization: User Interface and Beyond is the perfect resource for you. Author Lee Ambrosius is recognized as a leader in Au

  1. Evaluation of exposure limits to toxic gases for nuclear reactor control room operators

    International Nuclear Information System (INIS)

    Mahlum, D.D.; Sasser, L.B.

    1991-07-01

    We have evaluated ammonia, chlorine, Halon (actually a generic name for several halogenated hydro-carbons), and sulfur dioxide for their possible effects during an acute two-minute exposure in order to derive recommendations for maximum exposure levels. To perform this evaluation, we conducted a search to find the most pertinent literature regarding toxicity in humans and in experimental animals. Much of the literature is at least a decade old, not an unexpected finding since acute exposures are less often performed now than they were a few years ago. In most cases, the studies did not specifically examine the effects of two-minute exposures; thus, extrapolations had to be made from studies of longer-exposure periods. Whenever possible, we gave the greatest weight to human data, with experimental animal data serving to strengthen the conclusion arrived at from consideration of the human data. Although certain individuals show hypersensitivity to materials like sulfur dioxide, we have not attempted to factor this information into the recommendations. After our evaluation of the data in the literature, we held a small workshop. Major participants in this workshop were three consultants, all of whom were Diplomates of the American Board of Toxicology, and staff from the Nuclear Regulatory Commission. Our preliminary recommendations for two-minute exposure limits and the rationale for them were discussed and consensus reached on final recommendations. These recommendations are: (1) ammonia-300 to 400-ppm; (2) chlorine-30 ppm; (3) Halon 1301-5%; Halon 1211-2%; and (4) sulfur dioxide-100 ppm. Control room operators should be able to tolerate two-minute exposures to these levels, don fresh-air masks, and continue to operate the reactor if the toxic material is eliminated, or safely shut down the reactor if the toxic gas remains. 96 refs., 9 tabs

  2. Radiation exposure to a patients and personnel resulted from X-ray, TV and computed tomography controlled punctures

    International Nuclear Information System (INIS)

    Blokhina, N.G.; Poltavskij, A.V.; Drygin, V.N.; Artem'eva, N.V.; Bachiashvili, A.K.

    1987-01-01

    Radiation exposures to a patient and personnel resulted from two-pojection X-ray TV and computed tomography controlled diagnostic aimed punctures are studied. Radiation exposure to a patient as measured using a tissue-equivalent phantom. Measurements were conducted by thermoluminescent dosimetry method. It is shown that radiation exposure to a patient makes up 0.0176 Gy±18% under x-ray TV controlled punctures and 0.048 Gy±22% - under tomographic control. Radiation exposure to a doctor is quite high (over 0.3 of the annual maximum permissible dose)

  3. Human neutrophils in auto-immunity.

    Science.gov (United States)

    Thieblemont, Nathalie; Wright, Helen L; Edwards, Steven W; Witko-Sarsat, Véronique

    2016-04-01

    Human neutrophils have great capacity to cause tissue damage in inflammatory diseases via their inappropriate activation to release reactive oxygen species (ROS), proteases and other tissue-damaging molecules. Furthermore, activated neutrophils can release a wide variety of cytokines and chemokines that can regulate almost every element of the immune system. In addition to these important immuno-regulatory processes, activated neutrophils can also release, expose or generate neoepitopes that have the potential to break immune tolerance and result in the generation of autoantibodies, that characterise a number of human auto-immune diseases. For example, in vasculitis, anti-neutrophil cytoplasmic antibodies (ANCA) that are directed against proteinase 3 or myeloperoxidase are neutrophil-derived autoantigens and activated neutrophils are the main effector cells of vascular damage. In other auto-immune diseases, these neutrophil-derived neoepitopes may arise from a number of processes that include release of granule enzymes and ROS, changes in the properties of components of their plasma membrane as a result of activation or apoptosis, and via the release of Neutrophil Extracellular Traps (NETs). NETs are extracellular structures that contain chromatin that is decorated with granule enzymes (including citrullinated proteins) that can act as neo-epitopes to generate auto-immunity. This review therefore describes the processes that can result in neutrophil-mediated auto-immunity, and the role of neutrophils in the molecular pathologies of auto-immune diseases such as vasculitis, rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). We discuss the potential role of NETs in these processes and some of the debate in the literature regarding the role of this phenomenon in microbial killing, cell death and auto-immunity. Copyright © 2016 Elsevier Ltd. All rights reserved.

  4. Case-control study of maternal residential atrazine exposure and male genital malformations.

    Science.gov (United States)

    Agopian, A J; Lupo, Philip J; Canfield, Mark A; Langlois, Peter H

    2013-05-01

    Exposure to endocrine disrupting chemicals has been associated with risk for male genital malformations. However, residential prenatal exposure to atrazine, an endocrine disrupting pesticide, has not been evaluated. We obtained data from the Texas Birth Defects Registry for 16,433 cases with isolated male genital malformations and randomly selected, population-based controls delivered during 1999-2008. County-level estimates of atrazine exposure from the United States Geological Survey were linked to all subjects. We evaluated the relationship between estimated maternal residential atrazine exposure and risk for male genital malformations in offspring. Separate unconditional logistic regression analyses were conducted for hypospadias, cryptorchidism, and small penis. We observed modest, but consistent, associations between medium-low and/or medium levels of estimated periconceptional maternal residential atrazine exposure and every male genital malformation category evaluated (e.g., adjusted odds ratio for medium compared to low atrazine levels and all male genital malformations: 1.2, 95% confidence interval: 1.1-1.3). Previous literature from animal and epidemiological studies supports our findings. Our results provide further evidence of a suspected teratogenic role of atrazine. Copyright © 2012 Wiley Periodicals, Inc.

  5. Auto-communicating micro-orientalism

    DEFF Research Database (Denmark)

    Ren, Carina Bregnholm; Ooi, Can-Seng

    2013-01-01

    Using the concepts of auto-communication and micro-Orientalism, this article argues that nation branding at World Expos produces and propagates notions of difference and Otherness. We examine how Denmark presents itself in China, and how the message inevitably tells how the Danish authorities view...... exhibition is performed and regulated as sustainable and authentic and how in spite of its seemingly dialogical and interactive layout, a number of auto-communicative and micro-Orientalist practices are enacted. This study is based on field participation, observations and interviews. Public sources...

  6. Lithography focus/exposure control and corrections to improve CDU at post etch step

    Science.gov (United States)

    Kim, Young Ki; Yelverton, Mark; Tristan, John; Lee, Joungchel; Gutjahr, Karsten; Hsu, Ching-Hsiang; Wei, Hong; Wang, Lester; Li, Chen; Subramany, Lokesh; Chung, Woong Jae; Kim, Jeong Soo; Ramanathan, Vidya; Yap, LipKong; Gao, Jie; Karur-Shanmugam, Ram; Golotsvan, Anna; Herrera, Pedro; Huang, Kevin; Pierson, Bill

    2014-04-01

    As leading edge lithography moves to advanced nodes in high-mix, high-volume manufacturing environment, automated control of critical dimension (CD) within wafer has become a requirement. Current control methods to improve CD uniformity (CDU) generally rely upon the use of field by field exposure corrections via factory automation or through scanner sub-recipe. Such CDU control methods are limited to lithography step and cannot be extended to etch step. In this paper, a new method to improve CDU at post etch step by optimizing exposure at lithography step is introduced. This new solution utilizes GLOBALFOUNDRIES' factory automation system and KLA-Tencor's K-T Analyzer as the infrastructure to calculate and feed the necessary field by field level exposure corrections back to scanner, so as to achieve the optimal CDU at post etch step. CD at post lithography and post etch steps are measured by scatterometry metrology tools respectively and are used by K-T Analyzer as the input for correction calculations. This paper will explain in detail the philosophy as well as the methodology behind this novel CDU control solution. In addition, applications and use cases will be reviewed to demonstrate the capability and potential of this solution. The feasibility of adopting this solution in high-mix, high-volume manufacturing environment will be discussed as well.

  7. Repeated cocaine exposure facilitates the expression of incentive motivation and induces habitual control in rats.

    Directory of Open Access Journals (Sweden)

    Kimberly H LeBlanc

    Full Text Available There is growing evidence that mere exposure to drugs can induce long-term alterations in the neural systems that mediate reward processing, motivation, and behavioral control, potentially causing the pathological pursuit of drugs that characterizes the addicted state. The incentive sensitization theory proposes that drug exposure potentiates the influence of reward-paired cues on behavior. It has also been suggested that drug exposure biases action selection towards the automatic execution of habits and away from more deliberate goal-directed control. The current study investigated whether rats given repeated exposure to peripherally administered cocaine would show alterations in incentive motivation (assayed using the Pavlovian-to-instrumental transfer (PIT paradigm or habit formation (assayed using sensitivity to reward devaluation. After instrumental and Pavlovian training for food pellet rewards, rats were given 6 daily injections of cocaine (15 mg/kg, IP or saline, followed by a 10-d period of rest. Consistent with the incentive sensitization theory, cocaine-treated rats showed stronger cue-evoked lever pressing than saline-treated rats during the PIT test. The same rats were then trained on a new instrumental action with a new food pellet reward before undergoing a reward devaluation testing. Although saline-treated rats exhibited sensitivity to reward devaluation, indicative of goal-directed performance, cocaine-treated rats were insensitive to this treatment, suggesting a reliance on habitual processes. These findings, when taken together, indicate that repeated exposure to cocaine can cause broad alterations in behavioral control, spanning both motivational and action selection processes, and could therefore help explain aberrations of decision-making that underlie drug addiction.

  8. AutoCAD 2012 and AutoCAD LT 2012 No Experience Required

    CERN Document Server

    Gladfelter, Donnie

    2011-01-01

    The perfect step-by-step introduction to Autodesk's powerful architectural design software With this essential guide, you'll learn how to plan, develop, document, and present a complete AutoCAD project by building a summer cabin from start to finish. You can follow each step sequentially or jump in at any point by downloading the drawing files from the book's companion web site. You'll also master all essential AutoCAD features, get a thorough grounding in the basics, learn the very latest industry standards and techniques, and quickly become productive with AutoCAD 2012.Features concise expla

  9. AutoCAD 2015 and AutoCAD LT 2015 essentials

    CERN Document Server

    Onstott, Scott

    2014-01-01

    Step-by-step instructions for the AutoCAD fundamentals AutoCAD 2015 Essentials contains 400 pages of full-color, comprehensive instruction on the world's top drafting and architecture software. This 2015 edition features architectural, manufacturing, and landscape architecture examples. And like previous editions, the detailed guide introduces core concepts using interactive tutorials and open-ended projects, which can be completed in any order, thanks to downloadable data sets (an especially useful feature for students and professionals studying for Autodesk AutoCAD certification). Unlike man

  10. The risk of occupational injury increased according to severity of noise exposure after controlling for occupational environment status in Korea.

    Science.gov (United States)

    Yoon, Jin-Ha; Roh, Jaehoon; Kim, Chi-Nyon; Won, Jong-Uk

    2016-01-01

    The aim of this study was to examine the relationship between noise exposure and risk of occupational injury. Korean National Health and Nutrition Examination Survey was used for the current study. Self-report questionnaires were used to investigate occupational injury and exposure to noise, chemicals, and machines and equipments. In separate analyses for occupation and occupational hazard, the proportion of occupational injuries increased according to severity of noise exposure (all P exposure group, the respective odds ratio (95% confidence intervals) for occupational injury was 1.39 (1.07-1.80) and 1.67 (1.13-2.46) in the mild and severe noise exposure groups, after controlling for age, gender, sleep hours, work schedule (shift work), and exposure status to hazardous chemicals and hazardous machines and equipments. The current study highlights the association between noise exposure and risk of occupational injury. Furthermore, risk of occupational injury increased according to severity of noise exposure.

  11. System composition and operation of exposure dose registration and control system (Final report)

    International Nuclear Information System (INIS)

    1978-01-01

    Since November, 1976, the committee concerning the investigation of exposure dose registration and control system for employees in nuclear industries has discussed on the exposure dose registration and control system, issued the interim report (outline) in April, 1977, and continued to investigate the details organizing the working group. Here, the final report is presented. It describes first on the definition of the terms used and the basic concept of the exposure dose registration and control system, in which the name of that organization is decided as ''Central Registration Office for Radiation Works'', Radiation Influence Association, the foundational juridical person. Next, the works to be performed in the Center and nuclear energy enterprises are explained. The items concerning the business management at the time of practical execution are the major part of the report, and are over 22 items. These include the registration business, the official reporting business, inquiry and answer business about career, change and revision, and computer processing system. As the temporary measures for transfer ring to the new system, 10 items are also provided. Supplementary explanation of 9 important items is given in the appendix. (Wakatsuki, Y.)

  12. Cardio-autonomic control and wellbeing due to oscillating color light exposure.

    Science.gov (United States)

    Grote, Vincent; Kelz, Christina; Goswami, Nandu; Stossier, Harald; Tafeit, Erwin; Moser, Maximilian

    2013-04-10

    We investigated the cardio-autonomic and psychological effects of colored light cycling with the wavelength of ultradian rhythms. In two consecutive experiments, an explorative, longitudinal test followed by a randomized crossover design, 20 healthy subjects each were exposed to oscillating red, green and blue light. Heart rate, heart rate variability (HRV) and subjective wellbeing were measured. Significant effects of the oscillating color light exposure were observed for heart rate and cardio-autonomic control rhythms, derived from HRV (p≤.001). These effects on HRV were replicated in the second experiment in comparison to a similar white light exposure protocol (p≤.05). Vigilance showed improvement over the two weeks (p≤.001) in the longitudinal study. External color light cycling at the wavelength of blood pressure oscillations appears to amplify the endogenous autonomic oscillations. This leads to an optimization of cardio-autonomic control; an effect that was reflected shortly after the onset of the light exposure sessions by the increase of heart rate variability. From the results, we conclude that it takes repeated light exposure session to foster the positive effects on the psychological aspects, as we observed an increase of subjectively perceived mood only in the longitudinal study, not for the crossover design study. The results of our study imply some possible health effects of a color light exposure that is adjusted to 10 s and 1 min oscillations of humans' ultradian rhythms. These novel results show possible applications of oscillating visual inputs to the activation of processes connected to physiological regulation. Copyright © 2013 Elsevier Inc. All rights reserved.

  13. Trajectory Auto-Corrected image reconstruction.

    Science.gov (United States)

    Ianni, Julianna D; Grissom, William A

    2016-09-01

    To estimate k-space trajectory errors in non-Cartesian acquisitions and reconstruct distortion-free images, without trajectory measurements or gradient calibrations. The Trajectory Auto-Corrected image Reconstruction method jointly estimates k-space trajectory errors and images, based on SENSE and SPIRiT parallel imaging reconstruction. The underlying idea is that parallel imaging and oversampling in the center of k-space provides data redundancy that can be exploited to simultaneously reconstruct images and correct trajectory errors. Trajectory errors are represented as weighted sums of trajectory-dependent error basis functions, the coefficients of which are estimated using gradient-based optimization. Trajectory Auto-Corrected image Reconstruction was applied to reconstruct images and errors in golden angle radial, center-out radial, and spiral in vivo 7 Tesla brain acquisitions in five subjects. Compared to reconstructions using nominal trajectories, Trajectory auto-corrected image reconstructions contained considerably less blurring and streaking and were of similar quality to images reconstructed using measured k-space trajectories in the center-out radial and spiral cases. Reconstruction cost function reductions and improvements in normalized image gradient squared were also similar to those for images reconstructed using measured trajectories. Trajectory Auto-Corrected image Reconstruction enables non-Cartesian image reconstructions free from trajectory errors without the need for separate gradient calibrations or trajectory measurements. Magn Reson Med 76:757-768, 2016. © 2015 Wiley Periodicals, Inc. © 2015 Wiley Periodicals, Inc.

  14. Auto Euroopa Liidus kallim / Sulev Oll

    Index Scriptorium Estoniae

    Oll, Sulev, 1964-

    2001-01-01

    Euroopa Liiduga liitumisel tuleb uue auto eest välja käia vähemalt 10 000 krooni rohkem, kuna plaanide kohaselt ei tohi liikmesriikides autode hinnaerinevused ületada 12%. Ilmunud ka: Delovõje Vedomosti, 28. märts 2001, lk. 7

  15. Shape Analysis Using the Auto Diffusion Function

    DEFF Research Database (Denmark)

    Gebal, Katarzyna; Bærentzen, Jakob Andreas; Aanæs, Henrik

    2009-01-01

    Scalar functions defined on manifold triangle meshes is a starting point for many geometry processing algorithms such as mesh parametrization, skeletonization, and segmentation. In this paper, we propose the Auto Diffusion Function (ADF) which is a linear combination of the eigenfunctions...

  16. MICRO AUTO GASIFICATION SYSTEM: EMISSIONS CHARACTERIZATION

    Science.gov (United States)

    A compact, CONEX-housed waste to energy unit, Micro Auto Gasification System (MAGS), was characterized for air emissions from burning of military waste types. The MAGS unit is a dual chamber gasifier with a secondary diesel-fired combustor. Eight tests were conducted with multipl...

  17. Study of the effect of the variation of automatic exposure control in computed tomography

    International Nuclear Information System (INIS)

    Nersissian, D. Y.; Capeleti, F. F.; Furquin, T. A. C.; Melo, C. S.

    2011-01-01

    Teams computed tomography (CT) contain the current automatic control of exposure (CAE) which vary from the current X-ray tube in clinical protocols and deliver lower doses than those with fixed current. Alone is not enough control of dose, you need an acceptable image quality ensuring an accurate diagnosis. The TC regulate the flow of two ways: by considering the thickness of the patient and the attenuation by different tissues that intercept the x-ray Besides the advantage, there is the responsibility of proper use of different CAE systems, which require particular knowledge of each manufacturer of the CT.

  18. Parenteral exposure to pesticides and occurence of congenital malformations: hospital-based case-control study.

    Science.gov (United States)

    Ueker, Marly Eliane; Silva, Vivianne Monteiro; Moi, Gisele Pedroso; Pignati, Wanderley Antonio; Mattos, Ines Echenique; Silva, Ageo Mário Cândido

    2016-08-12

    Most fetal defects are associated with genetic and environmental causes, among them, exposure of pregnant women to intensive pesticide use. Agribusiness is the economic basis of the state of Mato Grosso, the largest consumer of pesticides of all Brazilian states. The objective of this study was to investigate the association between past parental exposure to pesticides and the occurrence of congenital malformations in children in Mato Grosso, Brazil. This hospital-based case-control study was conducted in Cuiabá, the capital of Mato Grosso, from March to October 2011. Data was collected in all public, private, and health plan referral hospitals that provide care for pregnant women in the state of Mato Grosso and were situated in Cuiabá. Cases were children under 5 years of age with congenital malformations classified in Chapter XVIII of the International Classification of Diseases-10 and controls were children within the same age range, without congenital malformations, treated at the same hospitals. Malformation-related data was obtained from the patients' medical records. Socioeconomic data and information about parental exposure to pesticides were obtained in an interview with the mother using a standardized questionnaire. We conducted multivariate logistic regression to assess the relation between parent report of past pesticide use and congenital malformations. We also assessed effect modification to verify whether low maternal education level modified the association between exposure and our outcome. We observed positive effect modification of the association of paternal past exposure to pesticide and congenital malformation in the offspring by maternal education for mothers with low educational level (OR = 8.40, 95 % CI 2.17-32.52), father's work related to farming (OR = 4.65, 95 % CI 1.03-20.98) and paternal past exposure to pesticides (OR = 4.15, 95 % CI 1.24-13.66). These findings provide further evidence that paternal exposure to

  19. The effect of exposure to missile attacks on posttraumatic stress disorder symptoms as a function of perceived media control and locus of control.

    Science.gov (United States)

    Hoffman, Yaakov S G; Shrira, Amit; Cohen-Fridel, Sara; Grossman, Ephraim S; Bodner, Ehud

    2016-10-30

    Exposure is one of the most robust predictors of post-traumatic stress disorder (PTSD) symptoms in warfare situations. Yet, while many are sensitive to exposure, others do not develop PTSD. In the current study, we address how perceived media control along with external locus of control moderate effects of exposure on PTSD symptoms among 1268 individuals exposed to missile attacks (mean age=36.97). We expected that the coupling of low perceived media control, whereby one feels poor control over media consumption (an inability to stop), especially when irrelevant and non-informative (e.g., involuntarily viewing the same terror incident shown repeatedly in a looped fashion) along with a self-perception of external locus of control, will render participants highly vulnerable to exposure. As expected, results suggest that effects of exposure on PTSD are not automatic, rather, the coupling of both low media control along with believing that life event are controlled by external factors exacerbates effects of exposure. These findings bear practical implications, as both media control and locus of control can be modified by therapeutic interventions, rendering one less vulnerable to the detrimental effects of traumatic exposure. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  20. Conversations with AutoTutor Help Students Learn

    Science.gov (United States)

    Graesser, Arthur C.

    2016-01-01

    AutoTutor helps students learn by holding a conversation in natural language. AutoTutor is adaptive to the learners' actions, verbal contributions, and in some systems their emotions. Many of AutoTutor's conversation patterns simulate human tutoring, but other patterns implement ideal pedagogies that open the door to computer tutors eclipsing…

  1. Efficiency calibration of solid track spark auto counter

    International Nuclear Information System (INIS)

    Wang Mei; Wen Zhongwei; Lin Jufang; Liu Rong; Jiang Li; Lu Xinxin; Zhu Tonghua

    2008-01-01

    The factors influencing detection efficiency of solid track spark auto counter were analyzed, and the best etch condition and parameters of charge were also reconfirmed. With small plate fission ionization chamber, the efficiency of solid track spark auto counter at various experiment assemblies was re-calibrated. The efficiency of solid track spark auto counter at various experimental conditions was obtained. (authors)

  2. 46 CFR 78.19-1 - Use of auto pilot.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 3 2010-10-01 2010-10-01 false Use of auto pilot. 78.19-1 Section 78.19-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) PASSENGER VESSELS OPERATIONS Auto Pilot § 78.19-1 Use of auto pilot. Except as provided in 33 CFR 164.15, when the automatic pilot is used in— (a...

  3. 46 CFR 97.16-1 - Use of auto pilot.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Use of auto pilot. 97.16-1 Section 97.16-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CARGO AND MISCELLANEOUS VESSELS OPERATIONS Auto Pilot § 97.16-1 Use of auto pilot. Except as provided in 33 CFR 164.15, when the automatic pilot is used...

  4. Exposure to and recall of violence reduce short-term memory and cognitive control.

    Science.gov (United States)

    Bogliacino, Francesco; Grimalda, Gianluca; Ortoleva, Pietro; Ring, Patrick

    2017-08-08

    Previous research has investigated the effects of violence and warfare on individuals' well-being, mental health, and individual prosociality and risk aversion. This study establishes the short- and long-term effects of exposure to violence on short-term memory and aspects of cognitive control. Short-term memory is the ability to store information. Cognitive control is the capacity to exert inhibition, working memory, and cognitive flexibility. Both have been shown to affect positively individual well-being and societal development. We sampled Colombian civilians who were exposed either to urban violence or to warfare more than a decade earlier. We assessed exposure to violence through either the urban district-level homicide rate or self-reported measures. Before undertaking cognitive tests, a randomly selected subset of our sample was asked to recall emotions of anxiety and fear connected to experiences of violence, whereas the rest recalled joyful or emotionally neutral experiences. We found that higher exposure to violence was associated with lower short-term memory abilities and lower cognitive control in the group recalling experiences of violence, whereas it had no effect in the other group. This finding demonstrates that exposure to violence, even if a decade earlier, can hamper cognitive functions, but only among individuals actively recalling emotional states linked with such experiences. A laboratory experiment conducted in Germany aimed to separate the effect of recalling violent events from the effect of emotions of fear and anxiety. Both factors had significant negative effects on cognitive functions and appeared to be independent from each other.

  5. Dialogical Exposure with Traumatically Bereaved Bosnian Women: Findings from a Controlled Trial.

    Science.gov (United States)

    Hagl, Maria; Powell, Steve; Rosner, Rita; Butollo, Willi

    2015-01-01

    In this trial, we compared the relative efficacy of dialogical exposure group treatment using Gestalt empty-chair method with a supportive group in the treatment of symptoms stemming from traumatic loss in a post-war society. One-hundred and nineteen women whose husbands were either killed or registered as missing during the war in Bosnia and Herzegovina were quasi-randomized to seven sessions of group treatment with dialogical exposure or to an active control condition. Both interventions resulted in significant improvement from baseline to post-treatment for both kinds of loss, in terms of post-traumatic symptoms, general mental health and grief reactions, with the exception of depression and traumatic grief in the control condition. Regarding mean effect sizes (Cohen's d), pre-treatment to post-treatment improvements were moderate (d = 0.56) for the dialogical exposure group and small (d = 0.34) for the supportive group. Treatment gains were maintained at least until the 1-year follow-up. In controlled comparisons, dialogical exposure was superior concerning traumatic grief (Cohen's d = 0.37) and post-traumatic avoidance (d = 0.73) at post-treatment. Results show that short-term dialogical exposure group treatment was moderately effective in treating traumatically bereaved women. Research attests to high levels of symptoms among post-war civil populations, in particular, when a loved one was killed, which can lead not only to trauma reactions but also to severe separation distress. Grieving the loss of a loved one is hampered if the death remains unconfirmed. Unconfirmed loss could be conceptualized as unfinished business in terms of Gestalt therapy, which offers empty-chair dialogue for resolving unfinished business and grief. Dialogical exposure therapy (DET) supports the client in gaining awareness of and expressing his or her inner dialogues concerning the traumatic event, using Gestalt empty-chair method. Short-term DET was effective in

  6. Optimization (Alara) and probabilistic exposures: the application of optimization criteria to the control of risks due to exposures of a probabilistic nature

    International Nuclear Information System (INIS)

    Gonzalez, A.J.

    1989-01-01

    The paper described the application of the principles of optimization recommended by the International Commission on Radiological Protection (ICRP) to the restrain of radiation risks due to exposures that may or may not be incurred and to which a probability of occurrence can be assigned. After describing the concept of probabilistic exposures, it proposes a basis for a converging policy of control for both certain and probabilistic exposures, namely the dose-risk relationship adopted for radiation protection purposes. On that basis some coherent approaches for dealing with probabilistic exposures, such as the limitation of individual risks, are discussed. The optimization of safety for reducing all risks from probabilistic exposures to as-low-as-reasonably-achievable (ALARA) levels is reviewed in full. The principles of optimization of protection are used as a basic framework and the relevant factors to be taken into account when moving to probabilistic exposures are presented. The paper also reviews the decision-aiding techniques suitable for performing optimization with particular emphasis to the multi-attribute utility-analysis technique. Finally, there is a discussion on some practical application of decision-aiding multi-attribute utility analysis to probabilistic exposures including the use of probabilistic utilities. In its final outlook, the paper emphasizes the need for standardization and solutions to generic problems, if optimization of safety is to be successful

  7. Evaluation of exposure to pioglitazone and risk of prostate cancer: a nested case–control study

    Science.gov (United States)

    Boxall, Naomi; Bennett, Dimitri; Hunger, Matthias; Dolin, Paul; Thompson, Paula L

    2016-01-01

    Objectives Investigate potential association between pioglitazone exposure and risk of prostate cancer. Research design and methods Nested, matched case–control study. UK primary care data (Clinical Practice Research Datalink (CPRD) GOLD) linked to inpatient (Hospital Episode Statistics (HES)) and cancer registry (National Cancer Information Network (NCIN)) data. English men aged ≥40 years diagnosed with type 2 diabetes mellitus, January 1, 2001 to January 5, 2015. Cases, with prostate cancer diagnosis, matched with up to 4 controls by age, cohort entry date and region. ORs for association of exposure to pioglitazone to incident prostate cancer, adjusted for potential confounders. Results From a cohort of 47 772 men with 243 923 person-years follow-up, 756 definite cases of prostate cancer were identified. Incidence was 309.9/100 000 person-years (95% CI 288.6 to 332.8). Pioglitazone use was not associated with prostate cancer risk; adjusted OR 0.759, 95% CI 0.502 to 1.148. Analyses showed no difference when possible cases, prostate cancer in CPRD GOLD only, included (adjusted OR 0.726, 95% CI 0.510 to 1.034). No association when adjusted for channeling bias (OR 0.778, 95% CI 0.511 to 1.184) or limited to an index date prior to July 1, 2011 (adjusted OR 0.508, 95% CI 0.294 to 0.879), despite prostate-specific antigen screening occurring more frequently among cases than controls (81.6% of 756 definite cases cf. 24.2% of 2942 controls (pworld, nested matched case–control study, exposure to pioglitazone was not associated with increased risk of prostate cancer. PMID:28074141

  8. Self-Image Development: A Chicano Enfasis. Self-Programmed Counseling and Self-Programmed Control. Instructor's Guide = Desarrollo de la Imagen Propia: Enfasis en el Chicano. Sistema de Consejo y Control Auto-Programado. Manuel del Profesor.

    Science.gov (United States)

    Mireles, S. Raymond

    Self-Programmed Counseling, the instructor's guidance, and Self-Programmed Control (SPC), the student's response, was initially developed by Title III Project USTED (United Students and Teachers for Educational Development) for Mexican American students on academic probation to use on a non-credit, special group counseling basis. As part of a…

  9. Case-control study of tobacco smoke exposure and breast cancer risk in Delaware

    Directory of Open Access Journals (Sweden)

    Hathcock H Leroy

    2008-06-01

    Full Text Available Abstract Background Tobacco smoke exposure may be associated with increased breast cancer risk, although the evidence supporting the association is inconclusive. We conducted a case-control study in Delaware, incorporating detailed exposure assessment for active and secondhand smoke at home and in the workplace. Methods Primary invasive breast cancer cases diagnosed among female Delaware residents, ages 40–79, in 2000–2002 were identified through the Delaware cancer registry (n = 287. Delaware drivers license and Health Care Finance Administration records were used to select age frequency-matched controls for women Results A statistically significant increased risk of breast cancer was observed for ever having smoked cigarettes (odds ratio = 1.43, 95% confidence interval = 1.03–1.99. However, there was no evidence of a dose-response relationship between breast cancer risk and total years smoked, cigarettes per day, or pack-years. Neither residential nor workplace secondhand smoke exposure was associated with breast cancer. Recalculations of active smoking risks using a purely unexposed reference group of women who were not exposed to active or secondhand smoking did not indicate increased risks of breast cancer. Conclusion These findings do not support an association between smoking and breast cancer.

  10. A Case-Control Study of Prenatal Thallium Exposure and Low Birth Weight in China.

    Science.gov (United States)

    Xia, Wei; Du, Xiaofu; Zheng, Tongzhang; Zhang, Bin; Li, Yuanyuan; Bassig, Bryan A; Zhou, Aifen; Wang, Youjie; Xiong, Chao; Li, Zhengkuan; Yao, Yuanxiang; Hu, Jie; Zhou, Yanqiu; Liu, Juan; Xue, Weiyan; Ma, Yue; Pan, Xinyun; Peng, Yang; Xu, Shunqing

    2016-01-01

    Thallium (Tl) is a highly toxic heavy metal widely present in the environment. Case reports have suggested that maternal exposure to high levels of Tl during pregnancy is associated with low birth weight (LBW), but epidemiological data are limited. This study was designed to evaluate whether prenatal Tl exposure is associated with an increased risk of LBW. This case-control study involving 816 study participants (204 LBW cases and 612 matched controls) was conducted in Hubei Province, China, in 2012-2014. Tl concentrations were measured in maternal urine collected at delivery, and associations with LBW were evaluated using conditional logistic regression. Higher maternal urinary Tl levels were significantly associated with increased risk of LBW [crude odds ratio (OR) = 1.52; 95% CI: 1.00, 2.30 for the highest vs. lowest tertile], and the association was similarly elevated after adjustment for potential confounders (adjusted OR = 1.90; 95% CI: 1.01, 3.58 for the highest vs. lowest tertile). Stratified analyses showed slightly higher risk estimates for LBW associated with higher Tl levels for mothers thallium exposure and low birth weight in China. Environ Health Perspect 124:164-169; http://dx.doi.org/10.1289/ehp.1409202.

  11. A Case–Control Study of Prenatal Thallium Exposure and Low Birth Weight in China

    Science.gov (United States)

    Xia, Wei; Du, Xiaofu; Zheng, Tongzhang; Zhang, Bin; Li, Yuanyuan; Bassig, Bryan A.; Zhou, Aifen; Wang, Youjie; Xiong, Chao; Li, Zhengkuan; Yao, Yuanxiang; Hu, Jie; Zhou, Yanqiu; Liu, Juan; Xue, Weiyan; Ma, Yue; Pan, Xinyun; Peng, Yang; Xu, Shunqing

    2015-01-01

    Background Thallium (Tl) is a highly toxic heavy metal widely present in the environment. Case reports have suggested that maternal exposure to high levels of Tl during pregnancy is associated with low birth weight (LBW), but epidemiological data are limited. Objectives This study was designed to evaluate whether prenatal Tl exposure is associated with an increased risk of LBW. Methods This case–control study involving 816 study participants (204 LBW cases and 612 matched controls) was conducted in Hubei Province, China, in 2012–2014. Tl concentrations were measured in maternal urine collected at delivery, and associations with LBW were evaluated using conditional logistic regression. Results Higher maternal urinary Tl levels were significantly associated with increased risk of LBW [crude odds ratio (OR) = 1.52; 95% CI: 1.00, 2.30 for the highest vs. lowest tertile], and the association was similarly elevated after adjustment for potential confounders (adjusted OR = 1.90; 95% CI: 1.01, 3.58 for the highest vs. lowest tertile). Stratified analyses showed slightly higher risk estimates for LBW associated with higher Tl levels for mothers thallium exposure and low birth weight in China. Environ Health Perspect 124:164–169; http://dx.doi.org/10.1289/ehp.1409202 PMID:26009470

  12. Metabolic syndrome and occupation: Any association? Prevalence among auto technicians and school teachers in South West Nigeria.

    Science.gov (United States)

    Akintunde, Adeseye A; Oloyede, Taiwo W

    2017-11-01

    To determine occupational association with metabolic syndrome among auto technicians and school teachers. One hundred and sixty six subjects were selected for this study. Clinical data was obtained while laboratory investigations including plasma glucose and lipid profile were performed. Statistical analysis was done with SPSS 20.0. Pauto technicians. Mean serum triglycerides was significantly higher among auto-technicians compared to school teachers in this study. The prevalence of some conventional cardiovascular risk factors was significantly higher among auto-technicians compared to school teachers: Impaired blood glucose (9.6% vs. 1.2%, pauto-technicians. Based on the WHO and the Harmonized criteria, metabolic syndrome was more frequent among auto-technicians compared to school teachers. (8.4% vs. 1.2% and 19.3% vs. 7.2% respectively, pauto technicians despite their high level of physical activity, exertion and education compared to teachers. This may be related to the increased occupational exposure to organic and inorganic materials from dust particles, oil and oil related matter and particulate matter among auto technicians. Prompt definitive evaluation of this concept and appropriate health education to encourage safety mechanism can reduce this burden of metabolic syndrome among auto technicians in Nigeria. Copyright © 2016 Diabetes India. Published by Elsevier Ltd. All rights reserved.

  13. What are the 'ideal' features of an adrenaline (epinephrine) auto-injector in the treatment of anaphylaxis?

    Science.gov (United States)

    Frew, A J

    2011-01-01

    Anaphylaxis is a systemic allergic reaction that often involves respiratory symptoms and cardiovascular collapse, which are potentially life-threatening if not treated promptly with intramuscular adrenaline. Owing to the unpredictable nature of anaphylaxis and accidental exposure to allergens (such as peanuts and shellfish), patients should be prescribed intramuscular adrenaline auto-injectors and carry these with them at all times. Patients also need to be able to use their auto-injectors correctly while under high stress, when an anaphylactic attack occurs. Despite this, an alarming number of patients fail to carry their auto-injectors and many patients, carers of children with known anaphylaxis and healthcare professionals do not know how to use the device correctly, despite having had training. Currently available auto-injector devices have various limitations that may impede their use in the management of anaphylaxis. There is also a lack of validated assessment criteria and regulatory requirements for new devices. This review describes the different delivery systems used in currently available auto-injectors and discusses the key barriers to the use of adrenaline auto-injectors, with the goal of identifying the 'ideal' features/characteristics of such devices in the emergency treatment of anaphylaxis that will ensure ease of use, portability and accurate delivery of a life-saving drug. © 2010 John Wiley & Sons A/S.

  14. Risk from exposure to trihalomethanes during shower: probabilistic assessment and control.

    Science.gov (United States)

    Chowdhury, Shakhawat; Champagne, Pascale

    2009-02-15

    Exposure to trihalomethanes (THMs) through inhalation and dermal contact during showering and bathing may pose risks to human health. During showering and bathing, warm water (35 degrees C-45 degrees C) is generally used. Warming of chlorinated supply water may increase THMs formation through enhanced reactions between organics and residual chlorine. Exposure assessment using THMs concentrations in cold water may under-predict the possible risks to human health. In this study, THMs concentrations in warm water were estimated by developing a THMs formation rate model. Using THMs in warm water, cancer and non-cancer risks to human health were predicted for three major cities in Ontario (Canada). The parameters for risk assessments were characterized by statistical distributions. The total cancer risks from exposure to THMs during showering were predicted to be 7.6x10(-6), 6.3x10(-6) and 4.3x10(-6) for Ottawa, Hamilton and Toronto respectively. The cancer risks exceedance probabilities were estimated to be highest in Ottawa at different risk levels. The risks through inhalation exposure were found to be comparable (2.1x10(-6)-3.7x10(-6)) to those of the dermal contact (2.2x10(-6)-3.9x10(-6)) for the cities. This study predicted 36 cancer incidents from exposure to THMs during showering for these three cities, while Toronto contributed the highest number of possible cancer incidents (22), followed by Ottawa (10) and Hamilton (4). The sensitivity analyses showed that health risks could be controlled by varying shower stall volume and/or shower duration following the power law relationship.

  15. Bone marrow function. I. Peripheral T cells are responsible for the increased auto-antiidiotype response of older mice

    International Nuclear Information System (INIS)

    Kim, Y.T.; Goidl, E.A.; Samarut, C.; Weksler, M.E.; Thorbecke, G.J.; Siskind, G.W.

    1985-01-01

    After immunization with trinitrophenyl (TNP)-Ficoll, mice produced both anti-TNP antibodies and auto-anti-idiotype (auto-anti-Id) antibodies specific for the anti-TNP antibody. Older animals produced more auto-anti-Id than did young animals. When mice were exposed to a normally lethal dose of irradiation while their bone marrow (BM) was partially shielded, they survived and slowly (6 wk) regained immune function, as indicated by the number of nucleated cells in their spleen and the in vitro primary plaque-forming cell (PFC) response of their spleen cells to TNP-treated aminoethylated polyacrylamide beads. Recovery is presumably the result of repopulation of the peripheral lymphoid system by cells originating in the BM. By enzyme-linked immunosorbent assay (ELISA), and by hapten-augmentable PFC assay, the authors show that, after recovery from irradiation with their BM shielded, old animals produce low auto-anti-Id responses, like those of young animals. The transfer of splenic T cells into mice irradiated with their BM shielded provided evidence that the magnitude of the auto-anti-Id response is controlled by the peripheral T cells. Thus, mice that received splenic T cells from aged donors produced high levels of auto-anti-Id while those that received splenic T cells from young donors produce low levels of auto-anti-Id

  16. Control of Indoor Airflows for Reduction of Human Exposure to Aerosol Contaminants

    DEFF Research Database (Denmark)

    Bivolarova, Mariya Petrova

    Air distribution in indoor environments is a critical factor of occupants’ exposure to airborne contaminants. There is a wide range of gaseous and biological contaminants which deteriorate the indoor air quality and thus affect negatively occupants’ health and performance. Increasing attention...... achieves the maximum efficiency with the minimum airflow rate, avoiding excessive installation and maintenance costs and more importantly, excessive energy use can be avoided. It is well-known that the most efficient method to prevent the risk of exposure is to control the contaminants directly or close...... to their source. A person, particularly his/her body, may be the primary source of unpleasant and even contagious contaminants in spaces. Dilution of the contaminated room air by supply of clean air, known as ventilation by dilution, is a recognised method for improving indoor air quality. The current method...

  17. Exposure to pistachio pesticides and stillbirth: a case-control study.

    Science.gov (United States)

    Razi, Saeid; Rezaeian, Mohsen; Dehkordi, Fatemeh Ghani; Manshoori, Azita; Goujani, Reza; Vazirinejad, Reza

    2016-01-01

    Stillbirth is an undesirable outcome of pregnancy. In light of the increasing use of pesticides and growing concerns about the possible health effects of agricultural pesticides, we investigated the effect of exposure to pistachio pesticides on stillbirth in pregnant mothers. This case-control study was conducted in Rafsanjan, Iran from 2011 to 2012. A total of 125 females who had a recent stillbirth were included as the case group, and 250 controls were selected from females who had a recent live birth. For each case, two controls with the nearest propensity score to the case were selected. Data were collected using a protocol developed by the researcher that involved interviewing respondents and reviewing their medical records. Conditional multivariate and univariate logistic regression analysis were performed and odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. The ORs of stillbirth in mothers living in pistachio gardens and those who were exposed to sprayed pesticides, in comparison to the controls, were 14.1 (95% CI, 3.3 to 63.4) and 5.0 (95% CI, 1.2 to 28.6), respectively. No significant differences were found in stillbirth rates according to the distance between the mother's residence and a pistachio garden or involvement in agricultural activities. The results of our study showed that exposure to pistachio pesticides during pregnancy may increase the likelihood of stillbirth in mothers.

  18. Leptospira Exposure and Patients with Liver Diseases: A Case-Control Seroprevalence Study

    Science.gov (United States)

    Alvarado-Esquivel, Cosme; Sánchez-Anguiano, Luis Francisco; Hernández-Tinoco, Jesús; Ramos-Nevárez, Agar; Margarita Cerrillo-Soto, Sandra; Alberto Guido-Arreola, Carlos

    2016-01-01

    The seroepidemiology of Leptospira infection in patients suffering from liver disease has been poorly studied. Information about risk factors associated with infection in liver disease patients may help in the optimal planning of preventive measures. We sought to determine the association of Leptospira IgG seroprevalence and patients with liver diseases, and to determine the characteristics of the patients with Leptospira exposure. We performed a case-control study of 75 patients suffering from liver diseases and 150 age- and gender-matched control subjects. Diagnoses of liver disease included liver cirrhosis, steatosis, chronic hepatitis, acute hepatitis, and amoebic liver abscess. Sera of participants were analyzed for the presence of anti- Leptospira IgG antibodies using a commercially available enzyme immunoassay. Anti-Leptospira IgG antibodies were found in 17 (22.7%) of 75 patients and in 15 (10.0%) of 150 control subjects (OR = 2.32; 95% CI: 1.09-4.94; P=0.03). This is the first age- and gender-matched case control study about Leptospira seroprevalence in patients with liver diseases. Results indicate that Leptospira infection is associated with chronic and acute liver diseases. Results warrants for additional studies on the role of Leptospira exposure in chronic liver disease. PMID:27493589

  19. Pregnancy Outcome Following Gestational Exposure to Fluoroquinolones: a Multicenter Prospective Controlled Study

    Science.gov (United States)

    Loebstein, Ronen; Addis, Antonio; Ho, Elaine; Andreou, Roseann; Sage, Suzanne; Donnenfeld, Alan E.; Schick, Betsy; Bonati, Maurizio; Moretti, Myla; Lalkin, Arieh; Pastuszak, Anne; Koren, Gideon

    1998-01-01

    Concerns regarding the teratogenicity of fluoroquinolones have resulted in their restricted use during gestation. This is despite an increasing need for their use due to emerging bacterial resistance. The objectives of the present investigation were to evaluate pregnancy and fetal outcomes following maternal exposure to fluoroquinolones and to examine whether in utero exposure to quinolones is associated with clinically significant musculoskeletal dysfunctions. We prospectively enrolled and followed up 200 women exposed to fluoroquinolones (norfloxacin, ciprofloxacin, ofloxacin) during gestation. Pregnancy outcome was compared with that for 200 controls matched for age and for smoking and alcohol consumption habits. Controls were exposed to nonteratogenic, nonembryotoxic antimicrobial agents matched by indication, duration of therapy (±3 days), and trimester of exposure. Rates of major congenital malformations did not differ between the group exposed to quinolones in the first trimester (2.2%) and the control group (2.6%) (relative risk, 0.85; 95% confidence interval, 0.21 to 3.49). Women treated with quinolones had a tendency for an increased rate of therapeutic abortions compared with the rate among women exposed to nonteratogens (relative risk, 4.50; 95% confidence interval, 0.98 to 20.57), resulting in lower live-birth rates (86 versus 94%; P = 0.02). The rates of spontaneous abortions, fetal distress, and prematurity and the birth weight did not differ between the groups. Gross motor developmental milestone achievements did not differ between the children of the mothers in the two groups. We concluded that the use of fluoroquinolones during embryogenesis is not associated with an increased risk of major malformations. There were no clinically significant musculoskeletal dysfunctions in children exposed to fluoroquinolones in utero. The higher rate of therapeutic abortions observed in quinolone-exposed women compared to that for their controls may be secondary

  20. Prenatal exposure to glycol ethers and cryptorchidism and hypospadias: a nested case-control study.

    Science.gov (United States)

    Warembourg, Charline; Botton, Jérémie; Lelong, Nathalie; Rouget, Florence; Khoshnood, Babak; Le Gléau, Florent; Monfort, Christine; Labat, Laurence; Pierre, Fabrice; Heude, Barbara; Slama, Rémy; Multigner, Luc; Charles, Marie-Aline; Cordier, Sylvaine; Garlantézec, Ronan

    2018-01-01

    Glycol ethers (GE) are oxygenated solvents frequently found in occupational and consumer products. Some of them are well-known testicular and developmental animal toxicants. This study aims to evaluate the risk of male genital anomalies in association with prenatal exposure to GE using urinary biomarkers of exposure. We conducted a case-control study nested in two joint mother-child cohorts (5303 pregnant women). Cases of cryptorchidism and hypospadias were identified at birth and confirmed during a 2-year follow-up period (n=14 cryptorchidism and n=15 hypospadias). Each case was matched to three randomly selected controls within the cohorts for region of inclusion and gestational age at urine sampling. Concentrations of five GE acidic metabolites were measured in spot maternal urine samples collected during pregnancy. ORs were estimated with multivariate conditional logistic regressions including a Firth's penalisation. Detection rates of urinary GE metabolites ranged from 8% to 93% and only two were sufficiently detected (>33%) in each cohort to be studied: methoxyacetic acid (MAA) and phenoxyacetic acid (PhAA). A significantly higher risk of hypospadias was associated with the highest tertile of exposure to MAA: OR (95% CI) 4.5(1.4 to 23.4). No association were observed with urinary concentration of PhAA, nor with the risk of cryptorchidism. In view of the toxicological plausibility of our results, this study, despite its small sample size, raises concern about the potential developmental toxicity of MAA on the male genital system and calls for thorough identification of current sources of exposure to MAA. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  1. Chronic alcohol exposure disrupts top-down control over basal ganglia action selection to produce habits.

    Science.gov (United States)

    Renteria, Rafael; Baltz, Emily T; Gremel, Christina M

    2018-01-15

    Addiction involves a predominance of habitual control mediated through action selection processes in dorsal striatum. Research has largely focused on neural mechanisms mediating a proposed progression from ventral to dorsal lateral striatal control in addiction. However, over reliance on habit striatal processes may also arise from reduced cortical input to striatum, thereby disrupting executive control over action selection. Here, we identify novel mechanisms through which chronic intermittent ethanol exposure and withdrawal (CIE) disrupts top-down control over goal-directed action selection processes to produce habits. We find CIE results in decreased excitability of orbital frontal cortex (OFC) excitatory circuits supporting goal-directed control, and, strikingly, selectively reduces OFC output to the direct output pathway in dorsal medial striatum. Increasing the activity of OFC circuits restores goal-directed control in CIE-exposed mice. Our findings show habitual control in alcohol dependence can arise through disrupted communication between top-down, goal-directed processes onto basal ganglia pathways controlling action selection.

  2. Auto-optimisation for three-dimensional conformal radiotherapy of nasopharyngeal carcinoma

    International Nuclear Information System (INIS)

    Wu, V.W.C.; Kwong, D.W.L.; Sham, J.S.T.; Mui, A.W.L.

    2003-01-01

    Purpose: The purpose of this study was to evaluate the application of auto-optimisation in the treatment planning of three-dimensional conformal radiotherapy (3DCRT) of nasopharyngeal carcinoma (NPC). Methods: Twenty-nine NPC patients were planned by both forward planning and auto-optimisation methods. The forward plans, which consisted of three coplanar facial fields, were produced according to the routine planning criteria. The auto-optimised plans, which consisted of 5-15 (median 9) fields, were generated by the planning system after prescribing the dose requirements and the importance weightings of the planning target volume and organs at risk. Plans produced by the two planning methods were compared by the dose volume histogram, tumour control probability (TCP), conformity index and normal tissue complication probability (NTCP). Results: The auto-optimised plans reduced the average planner's time by over 35 min. It demonstrated better TCP and conformity index than the forward plans (P=0.03 and 0.04, respectively). Besides, the parotid gland and temporo-mandibular (TM) joint were better spared with the mean dose reduction of 31.8 and 17.7%, respectively. The slight trade off was the mild dose increase in spinal cord and brain stem with their maximum doses remaining within the tolerance limits. Conclusions: The findings demonstrated the potentials of auto-optimisation for improving target dose and parotid sparing in the 3DCRT of NPC with saving of the planner's time

  3. Adrenaline auto-injectors for the treatment of anaphylaxis with and without cardiovascular collapse in the community.

    Science.gov (United States)

    Sheikh, Aziz; Simons, F Estelle R; Barbour, Victoria; Worth, Allison

    2012-08-15

    Anaphylaxis is a serious hypersensitivity reaction that is rapid in onset and may cause death. Adrenaline (epinephrine) auto-injectors are recommended as the initial, potentially life-saving treatment of choice for anaphylaxis in the community, but they are not universally available and have limitations in their use. To assess the effectiveness of adrenaline (epinephrine) auto-injectors in relieving respiratory, cardiovascular, and other symptoms during episodes of anaphylaxis that occur in the community. We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2012, Issue 1), MEDLINE (Ovid SP) (1950 to January 2012), EMBASE (Ovid SP) (1980 to January 2012 ), CINAHL (EBSCO host) (1982 to January 2012 ), AMED (EBSCO host) (1985 to January 2012 ), LILACS, (BIREME) (1980 to January 2012 ), ISI Web of Science (1950 to January 2012 ). We adapted our search terms for other databases. We also searched websites listing on-going trials: the World Health Organization International Clinical Trials Registry Platform, the UK Clinical Research Network Study Portfolio, and the meta Register of Controlled Trials; and contacted pharmaceutical companies who manufacture adrenaline auto-injectors in an attempt to locate unpublished material. Randomized and quasi-randomized controlled trials comparing auto-injector administration of adrenaline with any control including no intervention, placebo, or other adrenergic agonists were eligible for inclusion. Two authors independently assessed articles for inclusion. None of the 1328 studies that were identified satisfied the inclusion criteria. Based on this review, we cannot make any new recommendations on the effectiveness of adrenaline auto-injectors for the treatment of anaphylaxis. Although randomized, double-blind, placebo-controlled clinical trials of high methodological quality are necessary to define the true extent of benefits from the administration of adrenaline in anaphylaxis via an auto

  4. Anti-pentraxin 3 auto-antibodies might be protective in lupus nephritis: a large cohort study.

    Science.gov (United States)

    Yuan, Mo; Tan, Ying; Pang, Yun; Li, Yong-Zhe; Song, Yan; Yu, Feng; Zhao, Ming-Hui

    2017-11-01

    Anti-pentraxin 3 (PTX3) auto-antibodies were found to be associated with the absence of renal involvement in systemic lupus erythematosus (SLE). This study is to investigate the prevalence of anti-PTX3 auto-antibodies and their clinical significance based on a large Chinese lupus nephritis cohort. One hundred and ninety-six active lupus nephritis patients, 150 SLE patients without clinical renal involvement, and 100 healthy controls were enrolled. Serum anti-PTX3 auto-antibodies and PTX3 levels were screened by enzyme-linked immunosorbent assay (ELISA). The associations between anti-PTX3 auto-antibodies and clinicopathological parameters in lupus nephritis were further analyzed. Anti-PTX3 auto-antibodies were less prevalent in active lupus nephritis patients compared with SLE without renal involvement (19.4% (38/196) versus 40.7% (61/150), p auto-antibodies were negatively correlated with proteinuria in lupus nephritis (r = -.143, p = .047). The levels of proteinuria, serum creatinine, and the prevalence of thrombotic microangiopathy were significantly higher in patients with higher PTX3 levels (≥3.207 ng/ml) and without anti-PTX3 auto-antibodies compared with patients with lower PTX3 levels (auto-antibodies (4.79 (3.39-8.28) versus 3.95 (1.78-7.0), p = .03; 168.84 ± 153.63 versus 101.44 ± 47.36, p = .01; 34.1% (14/41) versus 0% (0/9), p = .04; respectively). Anti-PTX3 auto-antibodies were less prevalent in active lupus nephritis patients compared with SLE without renal involvement and associated with less severe renal damage, especially with the combined evaluation of serum PTX3 levels.

  5. Obesity and psyhological aspects: emotional and cognitive development, self concept, locus of control and anxiety / Obesidade e aspectos psicológicos: maturidade emocional, auto-conceito, locus de controle e ansiedade

    Directory of Open Access Journals (Sweden)

    Caroline Cataneo

    2005-01-01

    Full Text Available The present research aimed to evaluate if obese children showed different results in regard to some psychological variables such as emotional and cognitive development, locus of control, self concept , anxiety and behavioral problems compared to non obese children of same age, sex and school achievement. Subjects were 57 children with ages between 10 and 12 years old. The obese group had 27 children, 14 girls and 13 boys. The criterion for assignment to this group was the value of body mass above 85 percentile. The group of non obese had also 27 children, 15 girls and 12 boys and their body mass index was between 5 and 85 percentiles. There were no differences between the groups in regard to the variables approached. There were signs of psychological suffering in children of both groups. These results do not allow us to associate obesity with psychological or behavioral problems.

  6. Residential radon exposure and lung cancer risk in Misasa, Japan. A case-control study

    International Nuclear Information System (INIS)

    Sobue, Tomotaka; Lee, Valerie S.; Ye, Weimin; Tanooka, Hiroshi; Mifune, Masaaki; Suyama, Akihiko; Koga, Taeko; Morishima, Hiroshige; Kondo, Sohei

    2000-01-01

    In order to investigate an association between residential radon exposure and risk of lung cancer, a case-control study was conducted in Misasa Town, Tottori Prefecture, Japan. The case series consisted of 28 people who had died of lung cancer in the years 1976-96 and 36 controls chosen randomly from the residents in 1976, matched by sex and year of birth. Individual residential radon concentrations were measured for 1 year with alpha track detectors. The average radon concentration was 46 Bq/m 3 for cases and 51 Bq/m 3 for controls. Compared to the level of 24 or less Bq/m 3 , the adjusted odds ratios of lung cancer associated with radon levels of 25-49, 50-99 and 100 or more Bq/m 3 , were 1.13 (95% confidence interval; 0.29-4.40), 1.23 (0.16-9.39) and 0.25 (0.03-2.33), respectively. None of the estimates showed statistical significance, due to small sample size. When the subjects were limited to only include residents of more than 30 years, the estimates did not change substantially. This study did not find that the risk pattern of lung cancer, possibly associated with residential radon exposure, in Misasa Town differed from patterns observed in other countries. (author)

  7. Maternal Music Exposure during Pregnancy Influences Neonatal Behaviour: An Open-Label Randomized Controlled Trial

    Directory of Open Access Journals (Sweden)

    Ravindra Arya

    2012-01-01

    Full Text Available Objective. This study evaluated the effect of antenatal music exposure to primigravida healthy mothers on the behaviour of their term appropriate-for-date newborns assessed using Brazelton Neonatal Behavioral Assessment Scale (BNBAS. Methods. This was a single-centre, randomized, open-label controlled trial. Primigravida mothers aged 19–29 years, free of chronic medical diseases or significant deafness, with singleton pregnancy, with a gestation of 20 weeks or less, were randomized to listen to a pre-recorded music cassette for approximately 1 hour/day in addition to standard antenatal care (intervention arm or standard care only (control arm. Perinatal factors with adverse effect on neonatal behaviour were deemed as protocol violations. Outcome measure included scores on 7 clusters of BNBAS. Primary analysis was per protocol. The trial is registered with ClinicalTrials.gov (NCT01278329. Results. One hundred and twenty-six newborns in the music group and 134 in the control group were subjected to BNBAS assessment. The infants of mothers exposed to music during pregnancy performed significantly better on 5 of the 7 BNBAS clusters. The maximal beneficial effect was seen with respect to orientation (ES 1.13, 95% CI 0.82–1.44, <0.0001 and habituation (ES 1.05, 95% CI 0.53–1.57, =0.0001. Conclusion. Prenatal music exposure to mother significantly and favourably influences neonatal behaviour.

  8. Os processos auto-organizacionais do goalball

    Directory of Open Access Journals (Sweden)

    Márcio Pereira Morato

    2012-09-01

    Full Text Available O goalball é uma modalidade coletiva criada para pessoas com deficiência visual e baseada no tato e na audição. Partindo das contribuições das teorias sistêmicas, e entendendo as equipes e o jogo como sistemas, objetivamos interpretar os padrões e processos auto-organizacionais da modalidade. Para tal, observamos vinte jogos das Paralimpíadas de 2008. Distinguimos o ciclo auto-organizacional das equipes, um processo recursivo atrator de suas configurações. O histórico das relações entre as dimensões opostas das equipes representa o jogo. Cessada a interação cessa o jogo, permanecendo seu registro, que atuará recursivamente nas futuras preparações das equipes, oportunizando novos processos geradores de novos produtos, num interminável ciclo cuja causa e efeito, processo e produto se interligam.

  9. Gamma ray auto absorption correction evaluation methodology

    International Nuclear Information System (INIS)

    Gugiu, Daniela; Roth, Csaba; Ghinescu, Alecse

    2010-01-01

    Neutron activation analysis (NAA) is a well established nuclear technique, suited to investigate the microstructural or elemental composition and can be applied to studies of a large variety of samples. The work with large samples involves, beside the development of large irradiation devices with well know neutron field characteristics, the knowledge of perturbing phenomena and adequate evaluation of correction factors like: neutron self shielding, extended source correction, gamma ray auto absorption. The objective of the works presented in this paper is to validate an appropriate methodology for gamma ray auto absorption correction evaluation for large inhomogeneous samples. For this purpose a benchmark experiment has been defined - a simple gamma ray transmission experiment, easy to be reproduced. The gamma ray attenuation in pottery samples has been measured and computed using MCNP5 code. The results show a good agreement between the computed and measured values, proving that the proposed methodology is able to evaluate the correction factors. (authors)

  10. AutoCAD-To-GIFTS Translator Program

    Science.gov (United States)

    Jones, Andrew

    1989-01-01

    AutoCAD-to-GIFTS translator program, ACTOG, developed to facilitate quick generation of small finite-element models using CASA/GIFTS finite-element modeling program. Reads geometric data of drawing from Data Exchange File (DXF) used in AutoCAD and other PC-based drafting programs. Geometric entities recognized by ACTOG include points, lines, arcs, solids, three-dimensional lines, and three-dimensional faces. From this information, ACTOG creates GIFTS SRC file, which then reads into GIFTS preprocessor BULKM or modified and reads into EDITM to create finite-element model. SRC file used as is or edited for any number of uses. Written in Microsoft Quick-Basic (Version 2.0).

  11. Container code recognition in information auto collection system of container inspection

    International Nuclear Information System (INIS)

    Su Jianping; Chen Zhiqiang; Zhang Li; Gao Wenhuan; Kang Kejun

    2003-01-01

    Now custom needs electrical application and automatic detection. Container inspection should not only give the image of the goods, but also auto-attain container's code and weight. Its function and track control, information transfer make up the Information Auto Collection system of Container Inspection. Code Recognition is the point. The article is based on model match, the close property of character, and uses it to recognize. Base on checkout rule, design the adjustment arithmetic, form the whole recognition strategy. This strategy can achieve high recognition ratio and robust property

  12. Characterization, Exposure Measurement and Control for Nanoscale Particles in Workplaces and on the Road

    International Nuclear Information System (INIS)

    Wang Jing; Pui, David Y H

    2011-01-01

    The amount of engineered nanoparticles is increasing at a rapid rate and more concerns are being raised about the occupational health and safety of nanoparticles in the workplace, and implications of nanotechnology on the environment and living systems. At the same time, diesel engine emissions are one of the serious air pollution sources in urban area. Ultrafine particles on the road can result in harmful effects on the health of drivers and passengers. Research on characterization, exposure measurement and control is needed to address the environmental, health and safety issues of nanoscale particles. We present results of our studies on airborne particles in workplaces and on the road.

  13. Exposure to virtual social interactions in the treatment of social anxiety disorder: A randomized controlled trial.

    Science.gov (United States)

    Kampmann, Isabel L; Emmelkamp, Paul M G; Hartanto, Dwi; Brinkman, Willem-Paul; Zijlstra, Bonne J H; Morina, Nexhmedin

    2016-02-01

    This randomized controlled trial investigated the efficacy of a stand-alone virtual reality exposure intervention comprising verbal interaction with virtual humans to target heterogeneous social fears in participants with social anxiety disorder. Sixty participants (Mage = 36.9 years; 63.3% women) diagnosed with social anxiety disorder were randomly assigned to individual virtual reality exposure therapy (VRET), individual in vivo exposure therapy (iVET), or waiting-list. Multilevel regression analyses revealed that both treatment groups improved from pre-to postassessment on social anxiety symptoms, speech duration, perceived stress, and avoidant personality disorder related beliefs when compared to the waiting-list. Participants receiving iVET, but not VRET, improved on fear of negative evaluation, speech performance, general anxiety, depression, and quality of life relative to those on waiting-list. The iVET condition was further superior to the VRET condition regarding decreases in social anxiety symptoms at post- and follow-up assessments, and avoidant personality disorder related beliefs at follow-up. At follow-up, all improvements were significant for iVET. For VRET, only the effect for perceived stress was significant. VRET containing extensive verbal interaction without any cognitive components can effectively reduce complaints of generalized social anxiety disorder. Future technological and psychological improvements of virtual social interactions might further enhance the efficacy of VRET for social anxiety disorder. Copyright © 2015 Elsevier Ltd. All rights reserved.

  14. A model of auto immune response

    OpenAIRE

    Peterson, James K.; Kesson, Alison M.; King, Nicholas J. C.

    2017-01-01

    Background In this work, we develop a theoretical model of an auto immune response. This is based on modifications of standard second messenger trigger models using both signalling pathways and diffusion and a macro level dynamic systems approximation to the response of a triggering agent such as a virus, bacteria or environmental toxin. Results We show that there, in general, will be self damage effects whenever the triggering agent?s effect on the host can be separated into two distinct cla...

  15. HORMONAL CONTROL OF OVARIAN FUNCTION FOLLOWING CHLOROTRIAZINE EXPOSURE: EFFECT ON REPRODUCTIVE FUNCTION AND MAMMARY GLAND TUMOR DEVELOPMENT

    Science.gov (United States)

    Hormonal Control of Ovarian Function Following Chlorotriazine Exposure: Effect on Reproductive Function and Mammary Gland Tumor Development. Ralph L. Cooper, Susan C. Laws, Michael G. Narotsky, Jerome M. Goldman, and Tammy E. StokerAbstractThe studies review...

  16. Hand-spinning chrysotile exposure and risk of malignant mesothelioma: A case-control study in Southeastern China.

    Science.gov (United States)

    Jiang, Zhaoqiang; Chen, Tianhui; Chen, Junqiang; Ying, Shibo; Gao, Zhibin; He, Xianglei; Miao, Chao; Yu, Min; Feng, Lingfang; Xia, Hailing; Wu, Wei; Chen, Riping; Morinaga, Kenji; Lou, Jianlin; Zhang, Xing

    2018-02-01

    While chrysotile has been commonly used by Chinese textile industry for many years, investigations on the association of chrysotile exposure with risk of mesothelioma in China are scarce. We conducted a case-control study in a county located at Southeastern China, including 46 cases and 230 individually matched controls. A semi-quantitative method based on experts' assessment was used for evaluating hand-spinning chrysotile exposure. Conditional logistic regression models were used to assess the association of asbestos exposure with risk of mesothelioma. We found that hand-spinning chrysotile exposure was associated with significantly elevated risk of mesothelioma, reaching OR =10 (95% CIs: 1.4-65) for possible exposure and 64 (12-328) for definite exposure. Our data suggested a dose-response relationship of chrysotile exposure duration with risk of mesothelioma, reaching 28 (6-134) for  28.6 f/mL-years. We found a dose-response relationship of chrysotile exposure duration and CEI with risk of mesothelioma in Southeastern China, adding valuable information on health hazards of chrysotile exposure in China where chrysotile is still used nationwide. © 2017 UICC.

  17. Secondhand Smoke Exposure Reduction Intervention in Chinese Households of Young Children: A Randomized Controlled Trial.

    Science.gov (United States)

    Abdullah, Abu S; Hua, Fu; Khan, Hafiz; Xia, Xiao; Bing, Qi; Tarang, Kheradia; Winickoff, Jonathan P

    2015-01-01

    To assess whether a theory-based, community health worker-delivered intervention for household smokers will lead to reduced secondhand smoke exposure to children in Chinese families. Smoking parents or caregivers who had a child aged 5 years or younger at home were randomized to the intervention group (n = 164) to receive smoking hygiene intervention or to the comparison group (n = 154). The intervention was delivered by trained community health workers. Outcomes were assessed at 2- and 6- month follow-up. Of the 318 families randomized, 98 (60%) of 164 intervention group and 82 (53%) of 154 of controls completed 6-month follow-up assessment. At the 6-month follow-up, 62% of intervention and 45% of comparison group households adopted complete smoking restrictions at home (P = .022); total exposure (mean number of cigarettes per week ± standard deviation) from all smokers at home in the past 7 days was significantly lower among children in the intervention (3.29 ± 9.06) than the comparison (7.41 ± 14.63) group (P = .021); and mean urine cotinine level (ng/mL) was significantly lower in the intervention (0.030 ± .065) than the comparison (0.087 ± .027) group, P exposure to secondhand smoke. These findings have implications for the development of primary health care-based secondhand smoke exposure reduction and family oriented smoking cessation interventions as China moves toward a smoke-free society. Copyright © 2015 Academic Pediatric Association. Published by Elsevier Inc. All rights reserved.

  18. In-car nocturnal blue light exposure improves motorway driving: a randomized controlled trial.

    Science.gov (United States)

    Taillard, Jacques; Capelli, Aurore; Sagaspe, Patricia; Anund, Anna; Akerstedt, Torbjorn; Philip, Pierre

    2012-01-01

    Prolonged wakefulness greatly decreases nocturnal driving performance. The development of in-car countermeasures is a future challenge to prevent sleep-related accidents. The aim of this study is to determine whether continuous exposure to monochromatic light in the short wavelengths (blue light), placed on the dashboard, improves night-time driving performance. In this randomized, double-blind, placebo-controlled, cross-over study, 48 healthy male participants (aged 20-50 years) drove 400 km (250 miles) on motorway during night-time. They randomly and consecutively received either continuous blue light exposure (GOLite, Philips, 468 nm) during driving or 2*200 mg of caffeine or placebo of caffeine before and during the break. Treatments were separated by at least 1 week. The outcomes were number of inappropriate line crossings (ILC) and mean standard deviation of the lateral position (SDLP). Eight participants (17%) complained about dazzle during blue light exposure and were removed from the analysis. Results from the 40 remaining participants (mean age ± SD: 32.9±11.1) showed that countermeasures reduced the number of inappropriate line crossings (ILC) (F(2,91.11) = 6.64; pquality, quantity and timing of 3 subsequent nocturnal sleep episodes. Despite a lesser tolerance, a non-inferior efficacy of continuous nocturnal blue light exposure compared with caffeine suggests that this in-car countermeasure, used occasionally, could be used to fight nocturnal sleepiness at the wheel in blue light-tolerant drivers, whatever their age. More studies are needed to determine the reproducibility of data and to verify if it can be generalized to women. ClinicalTrials.gov NCT01070004.

  19. Measurements of auto-antibodies to α-synuclein in the serum and cerebral spinal fluids of patients with Parkinson's disease.

    Science.gov (United States)

    Akhtar, Rizwan S; Licata, Joseph P; Luk, Kelvin C; Shaw, Leslie M; Trojanowski, John Q; Lee, Virginia M-Y

    2018-03-03

    Biomarkers for α-synuclein are needed for diagnosis and prognosis in Parkinson's disease (PD). Endogenous auto-antibodies to α-synuclein could serve as biomarkers for underlying synucleinopathy, but previous assessments of auto-antibodies have shown variability and inconsistent clinical correlations. We hypothesized that auto-antibodies to α-synuclein could be diagnostic for PD and explain its clinical heterogeneity. To test this hypothesis, we developed an enzyme-linked immunosorbent assay for measuring α-synuclein auto-antibodies in human samples. We evaluated 69 serum samples (16 healthy controls (HC) and 53 PD patients) and 145 CSF samples (52 HC and 93 PD patients) from our Institution. Both serum and CSF were available for 24 participants. Males had higher auto-antibody levels than females in both fluids. CSF auto-antibody levels were significantly higher in PD patients as compared to HC, whereas serum levels were not significantly different. CSF auto-antibody levels did not associate with amyloid-β 1-42 , total tau, or phosphorylated tau. CSF auto-antibody levels correlated with performance on the Montreal Cognitive Assessment, even when controlled for CSF amyloidβ 1-42 . CSF hemoglobin levels, as a proxy for contamination of CSF by blood during lumbar puncture, did not influence these observations. Using recombinant α-synuclein with N- and C-terminal truncations, we found that CSF auto-antibodies target amino acids 100 through 120 of α-synuclein. We conclude that endogenous CSF auto-antibodies are significantly higher in PD patients as compared to HC, suggesting that they could indicate the presence of underlying synucleinopathy. These auto-antibodies associate with poor cognition, independently of CSF amyloidβ 1-42 ., and target a select C-terminal region of α-synuclein. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

  20. Automatic Transmissions and Transaxles. Auto Mechanics Curriculum Guide. Module 8. Instructor's Guide.

    Science.gov (United States)

    Hevel, David; Tannehill, Dana, Ed.

    This module is the eighth of nine modules in the competency-based Missouri Auto Mechanics Curriculum Guide. Six units cover: introduction to automatic transmission/transaxle; hydraulic control systems; transmission/transaxle diagnosis; automatic transmission/transaxle maintenance and adjustment; in-vehicle transmission repair; and off-car…

  1. AUTO-LAY: automatic layout generation for procedure flow diagrams

    International Nuclear Information System (INIS)

    Forzano, P.; Castagna, P.

    1995-01-01

    Nuclear Power Plant Procedures can be seen from essentially two viewpoints: the process and the information management. From the first point of view, it is important to supply the knowledge apt to solve problems connected with the control of the process, from the second one the focus of attention is on the knowledge representation, its structure, elicitation and maintenance, formal quality assurance. These two aspects of procedure representation can be considered and solved separately. In particular, methodological, formal and management issues require long and tedious activities, that in most cases constitute a great barrier for procedures development and upgrade. To solve these problems, Ansaldo is developing DIAM, a wide integrated tool for procedure management to support in procedure writing, updating, usage and documentation. One of the most challenging features of DIAM is AUTO-LAY, a CASE sub-tool that, in a complete automatical way, structures parts or complete flow diagrams. This is a feature that is partially present in some other CASE products, that, anyway, do not allow complex graph handling and isomorphism between video and paper representation AUTO-LAY has the unique prerogative to draw graphs of any complexity, to section them in pages, and to automatically compose a document. This has been recognized in the literature as the most important second-generation CASE improvement. (author). 5 refs., 9 figs

  2. Pesticide exposure and risk of Parkinson's disease: A family-based case-control study

    Directory of Open Access Journals (Sweden)

    Scott Burton L

    2008-03-01

    Full Text Available Abstract Background Pesticides and correlated lifestyle factors (e.g., exposure to well-water and farming are repeatedly reported risk factors for Parkinson's disease (PD, but few family-based studies have examined these relationships. Methods Using 319 cases and 296 relative and other controls, associations of direct pesticide application, well-water consumption, and farming residences/occupations with PD were examined using generalized estimating equations while controlling for age-at-examination, sex, cigarette smoking, and caffeine consumption. Results Overall, individuals with PD were significantly more likely to report direct pesticide application than their unaffected relatives (odds ratio = 1.61; 95% confidence interval, 1.13–2.29. Frequency, duration, and cumulative exposure were also significantly associated with PD in a dose-response pattern (p ≤ 0.013. Associations of direct pesticide application did not vary by sex but were modified by family history of PD, as significant associations were restricted to individuals with no family history. When classifying pesticides by functional type, both insecticides and herbicides were found to significantly increase risk of PD. Two specific insecticide classes, organochlorines and organophosphorus compounds, were significantly associated with PD. Consuming well-water and living/working on a farm were not associated with PD. Conclusion These data corroborate positive associations of broadly defined pesticide exposure with PD in families, particularly for sporadic PD. These data also implicate a few specific classes of pesticides in PD and thus emphasize the need to consider a more narrow definition of pesticides in future studies.

  3. Continuous Improvement of the Regulatory Framework for the Control of Medical Exposure

    International Nuclear Information System (INIS)

    Larcher, A.M.; Ortiz lopez, Pedro; Arias, Cesar; Marechal, Maria H.; Hernandez Alvarez, Ramon; Ferrer Garcia, Natividad; Castaneda Mucino, Antonia; Faller, Blanca

    2011-01-01

    Background: One of the key elements to guide the improvement of the regulatory control is the availability of a self-assessment tool for regulatory performance. Although there is general guidance on self-assessment for regulators and users (IAEA), there is a need for specific advice on how to address challenges and difficulties faced by regulatory bodies, when regulating radiation protection of patients. Examples of these challenges are the need of regulatory initiatives, in cooperation with health and education authorities, professional bodies and equipment suppliers, and to put in place necessary elements that are beyond responsibility of individual users of radiation, to enable them compliance with safety standards. Purpose: within the programme of the Ibero American Forum of Nuclear and Radiation Safety Regulatory Organizations, a project to develop such a self assessment tool for the regulatory control of medical exposure has been designed. Method: national experiences in transposing and enforcing the international radiation safety standards, as to how the requirements are included in national regulations are reviewed. Further, difficulties to the implementation of safety requirements are included in national regulations are analyzed and a self assessment approach and possible regulatory solutions are presented. Results and discussion: in tis study the following documents are being produced: 1) Transposition of international requirements into national regulations in the six countries of the Forum, 2) difficulties to implement and enforce the requirements, 3) guidance on self assessment of regulatory framework for medical exposure, 4) suggested contribution to the revision of international radiation safety standards. (authors)

  4. The effectiveness of Narrative Exposure Therapy with traumatised firefighters in Saudi Arabia: a randomized controlled study.

    Science.gov (United States)

    Alghamdi, Mohammed; Hunt, Nigel; Thomas, Shirley

    2015-03-01

    Firefighters are exposed to many traumatic events. The psychological costs of this exposure increase the risk of Post-Traumatic Stress disorder (PTSD), depression and anxiety. This study examined the effectiveness of Narrative Exposure Therapy (NET) as a short-term treatment for reducing PTSD symptoms among Saudi firefighters. A randomized waiting-list control study was conducted with 34 traumatized firefighters were randomly allocated to NET or Waiting-list Control (WLC). The NET group received four therapy sessions of 60-90 min over a three-week period; those in the WLC condition received the same sessions after a three-week waiting period. Participants in both groups were assessed at baseline, immediately post-intervention and at 3 and 6 month follow ups. NET led to significant reductions in PTSD symptoms, anxiety and depression compared with WLC. After the WLC group received treatment, it showed the same improvements as the NET group. This occurred immediately post-treatment in both groups, but was not sustained at 3 and 6 month follow ups. Coping strategies and social support led to significant changes only in follow up times. NET was effective in reducing PTSD symptoms in traumatised Saudi firefighters. This finding could be helpful in the management of PTSD among people who work as first responders such as firefighters, police officers and emergency medical personal, as well as security officers. Copyright © 2015. Published by Elsevier Ltd.

  5. Continuous improvement of the regulatory framework for the control of medical exposure

    International Nuclear Information System (INIS)

    Larcher, Ana M.; Ortiz Lopez, Pedro; Arias, Cesar; Marechal, Maria H.; Hernandez Alvarez, Ramon; Ferrer Garcia, Natividad; Castaneda Mucino, Antonia; Faller, Blanca

    2008-01-01

    One of the key elements to guide the improvement of the regulatory control is the availability of a self-assessment tool for regulatory performance. Although there is general guidance on self-assessment for regulators and users (IAEA), there is a need for more specific advice on how to address challenges and difficulties faced by regulatory bodies, when regulating radiation protection of patients. Examples of these challenges are the need for regulatory initiatives, in cooperation with health and education authorities, professional bodies and equipment suppliers, and to put in place necessary elements that are beyond responsibility of individual user of radiation, to enable them compliance with safety standards. Purpose: Within the programme of the Ibero American Forum of Nuclear and Radiation Safety Regulatory Organizations, a project to develop such a self-assessment tool for the regulatory control of medical exposure has been designed. Method: National experiences in transposing and enforcing the international radiation safety standards, as to how the requirements are included in national regulations are reviewed. Further, difficulties to the implementation of safety requirements are analyzed and a self-assessment approach and possible regulatory solutions a are presented. Results and discussion: In this study the following documents are being produced: 1) transposition of international requirements into national regulations in the six countries of the Forum, 2) difficulties to implement and enforce the requirements, 3) guidance on self-assessment of regulatory framework for medical exposure, 4) suggested contribution to the revision of international radiation safety standards. (author)

  6. Father's occupational exposure to carcinogenic agents and childhood acute leukemia: a new method to assess exposure (a case-control study

    Directory of Open Access Journals (Sweden)

    Rodriguez-Rivera Maria

    2008-01-01

    Full Text Available Abstract Background Medical research has not been able to establish whether a father's occupational exposures are associated with the development of acute leukemia (AL in their offspring. The studies conducted have weaknesses that have generated a misclassification of such exposure. Occupations and exposures to substances associated with childhood cancer are not very frequently encountered in the general population; thus, the reported risks are both inconsistent and inaccurate. In this study, to assess exposure we used a new method, an exposure index, which took into consideration the industrial branch, specific position, use of protective equipment, substances at work, degree of contact with such substances, and time of exposure. This index allowed us to obtain a grade, which permitted the identification of individuals according to their level of exposure to known or potentially carcinogenic agents that are not necessarily specifically identified as risk factors for leukemia. The aim of this study was to determine the association between a father's occupational exposure to carcinogenic agents and the presence of AL in their offspring. Methods From 1999 to 2000, a case-control study was performed with 193 children who reside in Mexico City and had been diagnosed with AL. The initial sample-size calculation was 150 children per group, assessed with an expected odds ratio (OR of three and a minimum exposure frequency of 15.8%. These children were matched by age, sex, and institution with 193 pediatric surgical patients at secondary-care hospitals. A questionnaire was used to determine each child's background and the characteristics of the father's occupation(s. In order to determine the level of exposure to carcinogenic agents, a previously validated exposure index (occupational exposure index, OEI was used. The consistency and validity of the index were assessed by a questionnaire comparison, the sensory recognition of the work area, and an

  7. Auto-recognition of surfaces and auto-generation of material removal volume for finishing process

    Science.gov (United States)

    Kataraki, Pramod S.; Salman Abu Mansor, Mohd

    2018-03-01

    Auto-recognition of a surface and auto-generation of material removal volumes for the so recognised surfaces has become a need to achieve successful downstream manufacturing activities like automated process planning and scheduling. Few researchers have contributed to generation of material removal volume for a product but resulted in material removal volume discontinuity between two adjacent material removal volumes generated from two adjacent faces that form convex geometry. The need for limitation free material removal volume generation was attempted and an algorithm that automatically recognises computer aided design (CAD) model’s surface and also auto-generate material removal volume for finishing process of the recognised surfaces was developed. The surfaces of CAD model are successfully recognised by the developed algorithm and required material removal volume is obtained. The material removal volume discontinuity limitation that occurred in fewer studies is eliminated.

  8. Exposure to professional pest control treatments and the risk of childhood acute lymphoblastic leukemia.

    Science.gov (United States)

    Bailey, Helen D; Armstrong, Bruce K; de Klerk, Nicholas H; Fritschi, Lin; Attia, John; Scott, Rodney J; Smibert, Elizabeth; Milne, Elizabeth

    2011-10-01

    Previous studies suggest that exposure to pesticides increases the risk of childhood acute lymphoblastic leukemia (ALL). The aim of this analysis was to investigate whether professional pest treatments in or around the home before birth or during childhood increased the risk of childhood ALL. Data from 388 cases and 870 frequency-matched controls were analyzed using unconditional logistic regression, adjusting for study matching variables and potential confounders, to calculate odds ratios (ORs). A meta-analysis of our findings with the published findings of previous studies was also conducted. The ORs for any professional pest control treatments were 1.19 (95% CI 0.83, 1.69) in the year before pregnancy, 1.30 (95% CI 0.86, 1.97) during pregnancy and 1.24 (95% CI 0.93, 1.65) for those done after the child's birth. The ORs for exposure after birth were highest when it occurred between the ages of two and three years. ORs were elevated for termite treatments before birth. ORs were higher for pre-B than T cell ALL and for t(12;21) (ETV6-Runx-1) than other cytogenetic sub-types. The pooled OR from a meta-analysis of our study with three previous studies of professional pest control treatments during pregnancy was 1.37 (95% CI 1.00, 1.88). Our results, and those of our meta-analysis, provide some evidence of a modestly increased risk of ALL for professional pest control treatments done during the index pregnancy and possibly in the child's early years. The analysis of pooled data from international collaborations may provide more certainty regarding these potentially important associations. Copyright © 2011 UICC.

  9. Association of prenatal exposure to benzodiazepines and child internalizing problems: A sibling-controlled cohort study.

    Directory of Open Access Journals (Sweden)

    Ragnhild E Brandlistuen

    Full Text Available During pregnancy, many women experience sleep problems and anxiety that require treatment. The long-term safety for the child of maternal benzodiazepine (BZD and z-hypnotic use during pregnancy remains controversial.We conducted a cohort and a sibling control study using data from the Norwegian Mother and Child Cohort Study. Data on use of BZD and z-hypnotics, internalizing and externalizing outcomes, and covariates were collected from mothers at gestational weeks 17 and 30 and when children were 0.5, 1.5, and 3 years of age. The total sample consisted of 71,996 children (19,297 siblings at 1.5 years and 55,081 children (13,779 siblings at 3 years. Short-term use was defined as use in one pregnancy period only. Long-term use was defined as use in two or more pregnancy periods. Linear full cohort random-effect and sibling-matched fixed-effect regression models were used to compare internalizing and externalizing behavior in children prenatally exposed compared to those unexposed in the full cohort of pregnancies accounting for family clusters, as well as within sibling clusters comparing pregnancies with discordant exposures. Propensity score (PS adjustment included variables on indication for use (sleep problems, symptoms of anxiety and depression and other potential confounding factors.Long-term prenatal exposure to BZD or z-hypnotics was associated with increased internalizing behavior in crude cohort analyses and at age 1.5 years after PS adjustment in sibling-matched fixed-effect models [β 0.60, 95% confidence interval 0.17-0.95]. Analyses on specific drug groups showed that prenatal exposure to BZD-anxiolytics was associated with increased internalizing problems at both 1.5 years [β 0.25, 0.01-0.49] and 3 years [β 0.26, 0.002-0.52] while exposure to z-hypnotics was not associated with any adverse outcomes after adjustment.The findings suggest a moderate association between BZD-anxiolytic exposure and child internalizing problems that is

  10. Anticoagulant rodenticide toxicity to non-target wildlife under controlled exposure conditions

    Science.gov (United States)

    Rattner, Barnett A.; Mastrota, F. Nicholas; van den Brink, Nico; Elliott, J.; Shore, R.; Rattner, B.

    2018-01-01

    Much of our understanding of anticoagulant rodenticide toxicity to non-target wildlife has been derived from molecular through whole animal research and registration studies in domesticated birds and mammals, and to a lesser degree from trials with captive wildlife. Using these data, an adverse outcome pathway identifying molecular initiating and anchoring events (inhibition of vitamin K epoxide reductase, failure to activate clotting factors), and established and plausible linkages (coagulopathy, hemorrhage, anemia, reduced fitness) associated with toxicity, is presented. Controlled exposure studies have demonstrated that second-generation anticoagulant rodenticides (e.g., brodifacoum) are more toxic than first- and intermediate-generation compounds (e.g., warfarin, diphacinone), however the difference in potency is diminished when first- and intermediate-generation compounds are administered on multiple days. Differences in species sensitivity are inconsistent among compounds. Numerous studies have compared mortality rate of predators fed prey or tissue containing anticoagulant rodenticides. In secondary exposure studies in birds, brodifacoum appears to pose the greatest risk, with bromadiolone, difenacoum, flocoumafen and difethialone being less hazardous than brodifacoum, and warfarin, coumatetralyl, coumafuryl, chlorophacinone and diphacinone being even less hazardous. In contrast, substantial mortality was noted in secondary exposure studies in mammals ingesting prey or tissue diets containing either second- or intermediate-generation compounds. Sublethal responses (e.g., prolonged clotting time, reduced hematocrit and anemia) have been used to study the sequelae of anticoagulant intoxication, and to some degree in the establishment of toxicity thresholds or toxicity reference values. Surprisingly few studies have undertaken histopathological evaluations to identify cellular lesions and hemorrhage associated with anticoagulant rodenticide exposure in non

  11. In Vivo versus Augmented Reality Exposure in the Treatment of Small Animal Phobia: A Randomized Controlled Trial.

    Science.gov (United States)

    Botella, Cristina; Pérez-Ara, M Ángeles; Bretón-López, Juana; Quero, Soledad; García-Palacios, Azucena; Baños, Rosa María

    2016-01-01

    Although in vivo exposure is the treatment of choice for specific phobias, some acceptability problems have been associated with it. Virtual Reality exposure has been shown to be as effective as in vivo exposure, and it is widely accepted for the treatment of specific phobias, but only preliminary data are available in the literature about the efficacy of Augmented Reality. The purpose of the present study was to examine the efficacy and acceptance of two treatment conditions for specific phobias in which the exposure component was applied in different ways: In vivo exposure (N = 31) versus an Augmented Reality system (N = 32) in a randomized controlled trial. "One-session treatment" guidelines were followed. Participants in the Augmented Reality condition significantly improved on all the outcome measures at post-treatment and follow-ups. When the two treatment conditions were compared, some differences were found at post-treatment, favoring the participants who received in vivo exposure. However, these differences disappeared at the 3- and 6-month follow-ups. Regarding participants' expectations and satisfaction with the treatment, very positive ratings were reported in both conditions. In addition, participants from in vivo exposure condition considered the treatment more useful for their problem whereas participants from Augmented Reality exposure considered the treatment less aversive. Results obtained in this study indicate that Augmented Reality exposure is an effective treatment for specific phobias and well accepted by the participants.

  12. In Vivo versus Augmented Reality Exposure in the Treatment of Small Animal Phobia: A Randomized Controlled Trial.

    Directory of Open Access Journals (Sweden)

    Cristina Botella

    Full Text Available Although in vivo exposure is the treatment of choice for specific phobias, some acceptability problems have been associated with it. Virtual Reality exposure has been shown to be as effective as in vivo exposure, and it is widely accepted for the treatment of specific phobias, but only preliminary data are available in the literature about the efficacy of Augmented Reality. The purpose of the present study was to examine the efficacy and acceptance of two treatment conditions for specific phobias in which the exposure component was applied in different ways: In vivo exposure (N = 31 versus an Augmented Reality system (N = 32 in a randomized controlled trial. "One-session treatment" guidelines were followed. Participants in the Augmented Reality condition significantly improved on all the outcome measures at post-treatment and follow-ups. When the two treatment conditions were compared, some differences were found at post-treatment, favoring the participants who received in vivo exposure. However, these differences disappeared at the 3- and 6-month follow-ups. Regarding participants' expectations and satisfaction with the treatment, very positive ratings were reported in both conditions. In addition, participants from in vivo exposure condition considered the treatment more useful for their problem whereas participants from Augmented Reality exposure considered the treatment less aversive. Results obtained in this study indicate that Augmented Reality exposure is an effective treatment for specific phobias and well accepted by the participants.

  13. AutoDrug: fully automated macromolecular crystallography workflows for fragment-based drug discovery.

    Science.gov (United States)

    Tsai, Yingssu; McPhillips, Scott E; González, Ana; McPhillips, Timothy M; Zinn, Daniel; Cohen, Aina E; Feese, Michael D; Bushnell, David; Tiefenbrunn, Theresa; Stout, C David; Ludaescher, Bertram; Hedman, Britt; Hodgson, Keith O; Soltis, S Michael

    2013-05-01

    AutoDrug is software based upon the scientific workflow paradigm that integrates the Stanford Synchrotron Radiation Lightsource macromolecular crystallography beamlines and third-party processing software to automate the crystallography steps of the fragment-based drug-discovery process. AutoDrug screens a cassette of fragment-soaked crystals, selects crystals for data collection based on screening results and user-specified criteria and determines optimal data-collection strategies. It then collects and processes diffraction data, performs molecular replacement using provided models and detects electron density that is likely to arise from bound fragments. All processes are fully automated, i.e. are performed without user interaction or supervision. Samples can be screened in groups corresponding to particular proteins, crystal forms and/or soaking conditions. A single AutoDrug run is only limited by the capacity of the sample-storage dewar at the beamline: currently 288 samples. AutoDrug was developed in conjunction with RestFlow, a new scientific workflow-automation framework. RestFlow simplifies the design of AutoDrug by managing the flow of data and the organization of results and by orchestrating the execution of computational pipeline steps. It also simplifies the execution and interaction of third-party programs and the beamline-control system. Modeling AutoDrug as a scientific workflow enables multiple variants that meet the requirements of different user groups to be developed and supported. A workflow tailored to mimic the crystallography stages comprising the drug-discovery pipeline of CoCrystal Discovery Inc. has been deployed and successfully demonstrated. This workflow was run once on the same 96 samples that the group had examined manually and the workflow cycled successfully through all of the samples, collected data from the same samples that were selected manually and located the same peaks of unmodeled density in the resulting difference Fourier

  14. Sarunvalodas elementi autožurnālos

    OpenAIRE

    Rode, Elīna

    2011-01-01

    Bakalaura darbs „Sarunvalodas elementi autožurnālos” ir pētījums, kas atspoguļo sarunvalodas elementu lietojumu autožurnālos. Darba mērķis: pētīt, sistematizēt un analizēt sarunvalodas elementu lietojumu autožurnālos, kas ir viens no publicistikas veidiem. Līdz šim sarunvalodas elementi autožurnālos nav pētīti nemaz. Darbu veido ievads un trīs galvenās daļas „Valodas funkcionālie paveidi”, „Sarunvaloda” un „Sarunvalodas elementi autožurnālos”, bet darbu noslēdz secinājumi. Autožurn...

  15. Exposure rate measurements and radiation control in post therapy with I131

    International Nuclear Information System (INIS)

    Vazquez A, M.; Castillo D, C.; Flores U, H.; Cespedes C, L.; Morgan N, C.; Sifuentes D, Y.; Marin R, K.

    2015-10-01

    During hyperthyroidism treatment, 131 I activities from 111 MBq up to 296 MBq are used. In the aim to determine if the 131 I uptake by the patient is a radiological risk to family members and public around the patient exposure rate measurements were carried out, using a limit 1.8 m R/h. Measurements were carried out in the Nuclear Medicine department of Almenara hospital in Lima, Peru. The exposure rate was measured to 0.3, 0.6, and 1.0 m from the patient from 0 to 11 days after post-administrated dose (Pda). In this study measurements were carried out in 21 hyperthyroid patients. Measurements to 1 meter, along 2-4 (16/16), 5-7 (15/15), and 8-11 (14/14) days after Pda, indicate the dose rate around 100% of patients is ≤ 1.8 m R /h. Measurements to 0.6 meters along 2-4 (16/16), 5 -7 (15/15), and 8-11 (14/14) days after Pda, indicate that the dose rate around 44% (7/16), 93% (14/15), and 100% (14/14) of patients is ≤ 1.8 m R h. On the other hand, dose rate measurements to 0.3 meters, along 2-4 (16/16), 5-7 (15/15), and 8 -11 (14/14) days after Pda, indicate that de dose rate is 13% (2/16), 6% (1/15), and 43% (6/14) of patients is ≤ 1.8 m R/h. Measured exposure rates are alike to values reported in the literature, and were used to define radiation control recommendations. (Author)

  16. Controlling the composition, microstructure, electrical and magnetic properties of LiFe{sub 5}O{sub 8} powders synthesized by sol gel auto-combustion method using urea as a fuel

    Energy Technology Data Exchange (ETDEWEB)

    Rashad, M.M., E-mail: rashad133@yahoo.com [Central Metallurgical Research and Development Institute (CMRDI), Helwan, Cairo (Egypt); El-Shaarawy, M.G.; Shash, N.M.; Maklad, M.H. [Physics Department, Benha University, Benha (Egypt); Afifi, F.A. [Basic Engineering Science Department, Faculty of Engineering, Benha university, Benha (Egypt)

    2015-01-15

    Nanocrystalline lithium ferrite LiFe{sub 5}O{sub 8} powders were synthesized by the sol gel auto-combustion method from the corresponding metal nitrates using urea as a fuel. DTA results showed that the LiFe{sub 5}O{sub 8} phase started to form at temperature around 385 °C. X-ray diffraction analysis indicates that all compositions were formed in a single-phase cubic spinel structure at different annealing temperatures from 400 to 800 °C for 2 h. The lattice parameter was found to decrease whereas the particle size was increased with annealing temperature. The frequency exponent “s” of lithium ferrite lies in the range 0.5≤s≤1, which confirmed the electron hopping between Fe{sup 2+} and Fe{sup 3+} ions. The electron mobility in LiFe{sub 5}O{sub 8} samples ranged from 0.05 to 0.29 eV, which clearly indicated that the present lithium ferrites have semiconductor-like behavior. The saturation magnetization was increased on increasing the annealing temperature up to 800 °C. High saturation magnetization (Ms=51.9 emu/g) was achieved for the ferrite powders produced at annealing temperature 800 °C for 2 h. - Highlights: • LiFe{sub 5}O{sub 8} phase was prepared at low temperature 400 °C. • Microstructure was temperature dependent. • Electron mobility ranged from 0.05 to 0.29 eV. • Frequency exponent “s” lies in the range 0.5≤s≤1 • Good magnetization was achieved.

  17. Theory and practice of Auto CAD, computer graphics

    International Nuclear Information System (INIS)

    Hwang, Si Won; Choe, Hong Yeong; Shin, Jae Yeon; Lee, Ryong Cheol

    1990-08-01

    This book describes theory and practice of Auto CAD, computer graphics, which deals with peripheral of computer, occurrence of digital line by DDA, BRM, theory of conversion, data base and display and shape modeling. This book gives descriptions of outline of CAD system, Auto CAD, basic function practice, simple figure practice, the third angle projection drawing a little complex single object, machine drawing I, function practice of improved Auto CAD, edit, set up layer, and 3D, and 3D display function.

  18. A new-generation 3D ozone FACE (Free Air Controlled Exposure).

    Science.gov (United States)

    Paoletti, Elena; Materassi, Alessandro; Fasano, Gianni; Hoshika, Yasutomo; Carriero, Giulia; Silaghi, Diana; Badea, Ovidiu

    2017-01-01

    To artificially simulate the impacts of ground-level ozone (O 3 ) on vegetation, ozone FACE (Free Air Controlled Exposure) systems are increasingly recommended. We describe here a new-generation, three-dimensional ozone FACE, with O 3 diffusion through laser-generated micro-holes, pre-mixing of air and O 3 , O 3 generator with integral oxygen generator, continuous (day/night) exposure and full replication. Based on three O 3 levels and assumptions on the pre-industrial O 3 levels, we describe principles to calculate relative yield/biomass and estimate impacts even at lower-than-ambient O 3 levels. The case study is called FO 3 X, and is at present the only ozone FACE in Mediterranean climate and one of the very few ozone FACEs investigating more than one stressor at a time. The results presented here will give further impulse to the research on O 3 impacts on vegetation all over the world. Copyright © 2016 Elsevier B.V. All rights reserved.

  19. Quartz dustiness: A key factor in controlling exposure to crystalline silica in the workplace.

    Science.gov (United States)

    López-Lilao, A; Escrig, A; Orts, M J; Mallol, Gustavo; Monfort, E

    2016-11-01

    The classification of Respirable Crystalline Silica (RCS) as carcinogenic for humans has drawn greater attention to crystalline silica exposure in the workplace in recent years, leading to recommendations by safety and health bodies in Europe and the U.S. for lower occupational exposure limits. In view of this new scenario, the present study examined quartz dustiness, as quartz handling is a major source of crystalline silica in the workplace. The study was conducted on test samples with different mean particle sizes, prepared from several commercial quartzes. The quartz particle samples were characterised and the influence of certain quartz particle parameters on quartz dustiness was determined. The results indicate that quartz dustiness may be significantly affected by mean particle size, specific surface area, the Hausner ratio, and fine particle content. The study shows that, in order to minimise the adverse health effects associated with the inhalation of crystalline silica, quartz dustiness may be deemed a key factor in controlling the generation of fugitive quartz emissions during quartz processing, both into the outside atmosphere (air pollution) and inside the facilities (occupational health).

  20. Eco-Material Selection for Auto Bodies

    Energy Technology Data Exchange (ETDEWEB)

    Mayyas, Ahmad T [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Omar, Mohammed [Masdar Institute of Science & Technology; Hayajneh, Mohammed T. [Jordan University of Science and Technology

    2017-09-25

    In the last decades, majority of automakers started to include lightweight materials in their vehicles to meet hard environmental regulations and to improve fuel efficiency of their vehicles. As a result, eco-material selection for vehicles emerged as a new discipline under design for environment. This chapter will summarize methods of eco-material selections for automotive applications with more emphasis into auto-bodies. A set of metrics for eco-material selection that takes into account all economic, environmental and social factors will be developed using numerical and qualitative methods. These metrics cover products' environmental impact, functionality and manufacturability, in addition to the economic and societal factors.

  1. A novel application of capnography during controlled human exposure to air pollution

    Directory of Open Access Journals (Sweden)

    Fila Michael

    2006-10-01

    waves in controlled human air pollution exposure studies is a feasible tool for characterization of cardio-pulmonary effects of such exposures.

  2. In-car nocturnal blue light exposure improves motorway driving: a randomized controlled trial.

    Directory of Open Access Journals (Sweden)

    Jacques Taillard

    Full Text Available Prolonged wakefulness greatly decreases nocturnal driving performance. The development of in-car countermeasures is a future challenge to prevent sleep-related accidents. The aim of this study is to determine whether continuous exposure to monochromatic light in the short wavelengths (blue light, placed on the dashboard, improves night-time driving performance. In this randomized, double-blind, placebo-controlled, cross-over study, 48 healthy male participants (aged 20-50 years drove 400 km (250 miles on motorway during night-time. They randomly and consecutively received either continuous blue light exposure (GOLite, Philips, 468 nm during driving or 2*200 mg of caffeine or placebo of caffeine before and during the break. Treatments were separated by at least 1 week. The outcomes were number of inappropriate line crossings (ILC and mean standard deviation of the lateral position (SDLP. Eight participants (17% complained about dazzle during blue light exposure and were removed from the analysis. Results from the 40 remaining participants (mean age ± SD: 32.9±11.1 showed that countermeasures reduced the number of inappropriate line crossings (ILC (F(2,91.11 = 6.64; p<0.05. Indeed, ILC were lower with coffee (12.51 [95% CI, 5.86 to 19.66], p = 0.001 and blue light (14.58 [CI, 8.75 to 22.58], p = 0.003 than with placebo (26.42 [CI, 19.90 to 33.71]. Similar results were found for SDLP. Treatments did not modify the quality, quantity and timing of 3 subsequent nocturnal sleep episodes. Despite a lesser tolerance, a non-inferior efficacy of continuous nocturnal blue light exposure compared with caffeine suggests that this in-car countermeasure, used occasionally, could be used to fight nocturnal sleepiness at the wheel in blue light-tolerant drivers, whatever their age. More studies are needed to determine the reproducibility of data and to verify if it can be generalized to women.ClinicalTrials.gov NCT01070004.

  3. Auto-Regulatory RNA Editing Fine-Tunes mRNA Re-Coding and Complex Behaviour in Drosophila

    Science.gov (United States)

    Savva, Yiannis A.; Jepson, James E.C; Sahin, Asli; Sugden, Arthur U.; Dorsky, Jacquelyn S.; Alpert, Lauren; Lawrence, Charles; Reenan, Robert A.

    2014-01-01

    Auto-regulatory feedback loops are a common molecular strategy used to optimize protein function. In Drosophila many mRNAs involved in neuro-transmission are re-coded at the RNA level by the RNA editing enzyme dADAR, leading to the incorporation of amino acids that are not directly encoded by the genome. dADAR also re-codes its own transcript, but the consequences of this auto-regulation in vivo are unclear. Here we show that hard-wiring or abolishing endogenous dADAR auto-regulation dramatically remodels the landscape of re-coding events in a site-specific manner. These molecular phenotypes correlate with altered localization of dADAR within the nuclear compartment. Furthermore, auto-editing exhibits sexually dimorphic patterns of spatial regulation and can be modified by abiotic environmental factors. Finally, we demonstrate that modifying dAdar auto-editing affects adaptive complex behaviors. Our results reveal the in vivo relevance of auto-regulatory control over post-transcriptional mRNA re-coding events in fine-tuning brain function and organismal behavior. PMID:22531175

  4. Renal effects of chronic exposure to organic solvents. A clinical controlled trial

    Energy Technology Data Exchange (ETDEWEB)

    Krusell, L.; Nielsen, H.K.; Baelum, J.; Lundqvist, G.; Omland, O.; Vaeth, M.; Husted, S.E.; Mogensen, C.E.; Geday, E.

    1985-01-01

    Chronic effects of organic solvents on renal function were measured by creatinine clearances and urinary excretion rates of beta 2-microglobulin and albumin. Forty-three male printing trade workers occupationally exposed to different organic solvents for 9-25 years were compared with 43 age-matched male controls. No differences were found either in creatinine clearances or average basal levels of beta 2-microglobulin and albumin excretion rates, whereas a positive relation could be demonstrated between alcohol consumption on the day before the trial and urinary excretion rate of albumin. This investigation did not reveal any adverse renal effects of moderate chronic exposure to organic solvents in a group of active trade workers.

  5. A randomized controlled study of exposure therapy as aftercare for alcohol use disorder

    DEFF Research Database (Denmark)

    Mellentin, Angelina Isabella; Nielsen, Bent; Nielsen, Anette Søgaard

    2016-01-01

    as an investigator-blinded randomized controlled trial. A total of 300 consecutively enrolled alcohol use disorder individuals recruited from an alcohol outpatient clinic will be randomized into one of the three following aftercare groups after concluding primary treatment: (1) CET as a smartphone application; (2......Background It is well documented that individuals with Alcohol Use Disorder (AUD) respond well during evidence-based psychological treatment, but also that a large proportion relapses when discharged from treatment and confronted with alcohol in real life. Cue Exposure Treatment (CET) focuses...... on exposing individuals to alcohol cues in order to reduce cravings as well as the likelihood of relapse. The aims of the study are: 1) to investigate whether CET aftercare delivered via a smartphone or in group sessions increases the effect of Cognitive Behavioural Treatment in groups of alcohol dependent...

  6. Carbon monoxide exposure from commercial brand cigarettes under controlled smoking conditions.

    Science.gov (United States)

    Weinhold, L L; Stitzer, M L; Yingling, J E

    1988-09-01

    Carbon monoxide (CO) exposure from ultralow-, low- and high-CO delivery commercial cigarettes was examined under controlled smoking conditions. Seven chronic smokers of mid- to high-CO delivery commercial cigarettes served in the experiment. CO level increases of 2.10, 5.76 and 7.38 ppm were obtained from ultralow-yield (1.6 mg CO delivery), low-yield (5.9 mg CO delivery) and high-yield (14.3 mg CO delivery) cigarettes, respectively. Subjects achieved significantly higher increases in CO levels from both low- and high-yield cigarettes than from ultralow-yield cigarettes, but increased levels of CO from low- and high-yield cigarettes were not different from each other. The data suggest that degree of CO absorption by the lungs during a short period of time may limit increases in CO levels obtained from high-yield cigarettes.

  7. Effects of personalised exposure on self-rated electromagnetic hypersensitivity and sensibility - A double-blind randomised controlled trial.

    Science.gov (United States)

    van Moorselaar, Imke; Slottje, Pauline; Heller, Pia; van Strien, Rob; Kromhout, Hans; Murbach, Manuel; Kuster, Niels; Vermeulen, Roel; Huss, Anke

    2017-02-01

    Previous provocation experiments with persons reporting electromagnetic hypersensitivity (EHS) have been criticised because EHS persons were obliged to travel to study locations (seen as stressful), and that they were unable to select the type of signal they reported reacting to. In our study we used mobile exposure units that allow double-blind exposure conditions with personalised exposure settings (signal type, strength, duration) at home. Our aim was to evaluate whether subjects were able to identify exposure conditions, and to assess if providing feedback on personal test results altered the level of self-reported EHS. We used double-blind randomised controlled exposure testing with questionnaires at baseline, immediately before and after testing, and at two and four months post testing. Participants were eligible if they reported sensing either radiofrequency or extremely low frequency fields within minutes of exposure. Participants were visited at home or another location where they felt comfortable to undergo testing. Before double-blind testing, we verified together with participants in an unblinded exposure session that the exposure settings were selected were ones that the participant responded to. Double-blind testing consisted of a series of 10 exposure and sham exposures in random sequence, feedback on test results was provided directly after testing. 42 persons participated, mean age was 55years (range 29-78), 76% were women. During double-blind testing, no participant was able to correctly identify when they were being exposed better than chance. There were no statistically significant differences in the self-reported level of EHS at follow-up compared to baseline, but during follow-up participants reported reduced certainty in reacting within minutes to exposure and reported significantly fewer symptoms compared to baseline. Our results suggest that a subgroup of persons exist who profit from participation in a personalised testing procedure

  8. Risk Assessment and Control through Countermeasure System Iplementation for Long-term Crew Exposure to Microgravity

    Science.gov (United States)

    Gernand, Jeremy M.

    2004-01-01

    Experience with the International Space Station (ISS) program demonstrates the degree to which engineering design and operational solutions must protect crewmembers from health risks due to long-term exposure to the microgravity environment. Risks to safety and health due to degradation in the microgravity environment include crew inability to complete emergency or nominal activities, increased risk of injury, and inability to complete safe return to the ground due to reduced strength or embrittled bones. These risks without controls slowly increase in probability for the length of the mission and become more significant for increasing mission durations. Countermeasures to microgravity include hardware systems that place a crewmember s body under elevated stress to produce an effect similar to daily exposure to gravity. The ISS countermeasure system is predominately composed of customized exercise machines. Historical treatment of microgravity countermeasure systems as medical research experiments unintentionally reduced the foreseen importance and therefore the capability of the systems to function in a long-term operational role. Long-term hazardous effects and steadily increasing operational risks due to non-functional countermeasure equipment require a more rigorous design approach and incorporation of redundancy into seemingly non- mission-critical hardware systems. Variations in the rate of health degradation and responsiveness to countermeasures among the crew population drastically increase the challenge for design requirements development and verification of the appropriate risk control strategy. The long-term nature of the hazards and severe limits on logistical re-supply mass, volume and frequency complicates assessment of hardware availability and verification of an adequate maintenance and sparing plan. Design achievement of medically defined performance requirements by microgravity countermeasure systems and incorporation of adequate failure tolerance

  9. Factors affecting exposure level for medical staff during orthopedic procedures under fluoroscopic control

    Directory of Open Access Journals (Sweden)

    Maria A. Staniszewska

    2017-02-01

    Full Text Available Background: Extended control of staff exposure in interventional radiology has been legally required over the last few years. This is determined by a number of factors, including the type of procedure, technical conditions and methodology. In orthopedic procedures fluoroscopy is used to control surgical reconstructions. An influence of particular factors on the registered values of doses received by the members of medical team performing osteosynthesis for limb fractures is presented in this paper. Material and Methods: Doses received by individual interventional team members performing specific functions, operator, assisting physicians and scrub nurse, during a series of the procedures were measured. Each person was equipped with 4 dosimetric tools, containing thermoluminescent dosimeters, to measure the equivalent doses for the eyes, hand skin and the neck (outside the shield and to evaluate effective doses. The investigations were performed in operational theatres of 3 hospitals in Łódź. Results: The equivalent doses per one procedure for the eyes and hand skin of the operator were 0.029–0.073 mSv and 0.366–1.604 mSv, respectively. Significantly higher doses were noted during the procedures of intramedullary osteosynthesis, especially for the operator. An average age and body mass index (BMI of patients treated in the monitored hospitals did not differ statistically. Conclusions: Based on the dosimetric measurements the following conclusions can be drawn: in orthopedic procedures of interventional radiology (IR the exposure of the staff is mostly determined by the type of procedure and more precisely by its complexity and by the optimized use of X-ray unit, including pulsed fluoroscopy. It is also revealed that the operator is the most exposed person in the interventional team. Med Pr 2017;68(1:75–83

  10. Optimal Recovery Trajectories for Automatic Ground Collision Avoidance Systems (Auto GCAS)

    Science.gov (United States)

    Suplisson, Angela W.

    The US Air Force recently fielded the F-16 Automatic Ground Collision Avoidance System (Auto GCAS). This system meets the operational requirements of being both aggressive and timely, meaning that extremely agile avoidance maneuvers will be executed at the last second to avoid the ground. This small window of automatic operation maneuvering in close proximity to the ground makes the problem challenging. There currently exists no similar Auto GCAS for manned military 'heavy' aircraft with lower climb performance such as transport, tanker, or bomber aircraft. The F-16 Auto GCAS recovery is a single pre-planned roll to wings-level and 5-g pull-up which is very effective for fighters due to their high g and climb performance, but it is not suitable for military heavy aircraft. This research proposes a new optimal control approach to the ground collision avoidance problem for heavy aircraft by mapping the aggressive and timely requirements of the automatic recovery to the optimal control formulation which includes lateral maneuvers around terrain. This novel mapping creates two ways to pose the optimal control problem for Auto GCAS; one as a Max Distance with a Timely Trigger formulation and the other as a Min Control with an Aggressive Trigger formulation. Further, the optimal path and optimal control admitted by these two formulations are demonstrated to be equivalent at the point the automatic recovery is initiated for the simplified 2-D case. The Min Control formulation was demonstrated to have faster computational speed and was chosen for the 3-D case. Results are presented for representative heavy aircraft scenarios against 3-D digital terrain. The Min Control formulation was then compared to a Multi-Trajectory Auto GCAS with five pre-planned maneuvers. Metrics were developed to quantify the improvement from using an optimal approach versus the pre-planned maneuvers. The proposed optimal Min Control method was demonstrated to require less control or trigger later

  11. Longitudinal study of Thai people media exposure, knowledge, and behavior on dengue fever prevention and control.

    Science.gov (United States)

    Boonchutima, Smith; Kachentawa, Kirati; Limpavithayakul, Manasanun; Prachansri, Anan

    Dengue hemorrhagic fever is transmitted through a bite by a dengue -infected Aedes aegypti mosquito. It was first reported in the mid -20th century in Thailand, and since then its epidemiology has been of great concern and has spread all across the country. The alarming incidence of dengue posed a serious threat to human health in all major cities of Thailand. This study was aimed at identifying the level of awareness of dengue fever in Thai population knowledge for prevention and control, and most importantly contribution of media in educating masses for dengue control measures. It is longitudinal in nature and was conducted in 25 provinces of Thailand during 2013-2015. Approximately 7772 respondents participated in this study, with the selection of provinces based on considerations like population, prevalence and demography. A pre-tested structured questionnaire was used to collect information relevant to study participants' demographic profile, pre-existing knowledge about dengue fever and its reinforcement through media, and population attitudes toward prevention and control. Over the period of three years, a positive trend was revealed relevant to the contribution of media in educating and reminding the Thai population of dengue, without any uniformity or powerful campaigns. Based on the results drawn from this study, we conclude that despite the measures undertaken to prevent dengue fever, there is insufficient media exposure. An interdisciplinary approach involving the community participation, media, and government is needed to overcome dengue threat in Thailand. Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.

  12. Formaldehyde and acetaldehyde exposure mitigation in US residences: In-home measurements of ventilation control and source control

    Energy Technology Data Exchange (ETDEWEB)

    Hult, Erin L. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Willem, Henry [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Price, Phillip N. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Hotchi, Toshifumi [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Russell, Marion L. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Singer, Brett C. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

    2014-10-01

    Measurements were taken in new US residences to assess the extent to which ventilation and source control can mitigate formaldehyde exposure. Increasing ventilation consistently lowered indoor formaldehyde concentrations. However, at a reference air exchange rate of 0.35 h-1, increasing ventilation was up to 60% less effective than would be predicted if the emission rate were constant. This is consistent with formaldehyde emission rates decreasing as air concentrations increase, as observed in chamber studies. In contrast, measurements suggest acetaldehyde emission was independent of ventilation rate. To evaluate the effectiveness of source control, formaldehyde concentrations were measured in Leadership in Energy and Environmental Design (LEED) certified/Indoor airPLUS homes constructed with materials certified to have low emission rates of volatile organic compounds (VOC). At a reference air exchange rate of 0.35 h-1, and adjusting for home age, temperature and relative humidity, formaldehyde concentrations in homes built with low-VOC materials were 42% lower on average than in reference new homes with conventional building materials. Without adjustment, concentrations were 27% lower in the low-VOC homes. The mean and standard deviation of formaldehyde concentration were 33 μg m-3 and 22 μg m-3 for low-VOC homes and 45 μg m-3 and 30 μg m-3 for conventional.

  13. Formaldehyde and acetaldehyde exposure mitigation in US residences: in-home measurements of ventilation control and source control.

    Science.gov (United States)

    Hult, E L; Willem, H; Price, P N; Hotchi, T; Russell, M L; Singer, B C

    2015-10-01

    Measurements were taken in new US residences to assess the extent to which ventilation and source control can mitigate formaldehyde exposure. Increasing ventilation consistently lowered indoor formaldehyde concentrations. However, at a reference air exchange rate of 0.35 h(-1), increasing ventilation was up to 60% less effective than would be predicted if the emission rate were constant. This is consistent with formaldehyde emission rates decreasing as air concentrations increase, as observed in chamber studies. In contrast, measurements suggest acetaldehyde emission was independent of ventilation rate. To evaluate the effectiveness of source control, formaldehyde concentrations were measured in Leadership in Energy and Environmental Design (LEED)-certified/Indoor airPLUS homes constructed with materials certified to have low emission rates of volatile organic compounds (VOC). At a reference air exchange rate of 0.35 h(-1), and adjusting for home age, temperature and relative humidity, formaldehyde concentrations in homes built with low-VOC materials were 42% lower on average than in reference new homes with conventional building materials. Without adjustment, concentrations were 27% lower in the low-VOC homes. The mean and standard deviation of formaldehyde concentration was 33 μg/m(3) and 22 μg/m(3) for low-VOC homes and 45 μg/m(3) and 30 μg/m(3) for conventional. Published 2014. This article is a U.S. Government work and is in the public domain in the USA.

  14. Investigating the Simulink Auto-Coding Process

    Science.gov (United States)

    Gualdoni, Matthew J.

    2016-01-01

    Model based program design is the most clear and direct way to develop algorithms and programs for interfacing with hardware. While coding "by hand" results in a more tailored product, the ever-growing size and complexity of modern-day applications can cause the project work load to quickly become unreasonable for one programmer. This has generally been addressed by splitting the product into separate modules to allow multiple developers to work in parallel on the same project, however this introduces new potentials for errors in the process. The fluidity, reliability and robustness of the code relies on the abilities of the programmers to communicate their methods to one another; furthermore, multiple programmers invites multiple potentially differing coding styles into the same product, which can cause a loss of readability or even module incompatibility. Fortunately, Mathworks has implemented an auto-coding feature that allows programmers to design their algorithms through the use of models and diagrams in the graphical programming environment Simulink, allowing the designer to visually determine what the hardware is to do. From here, the auto-coding feature handles converting the project into another programming language. This type of approach allows the designer to clearly see how the software will be directing the hardware without the need to try and interpret large amounts of code. In addition, it speeds up the programming process, minimizing the amount of man-hours spent on a single project, thus reducing the chance of human error as well as project turnover time. One such project that has benefited from the auto-coding procedure is Ramses, a portion of the GNC flight software on-board Orion that has been implemented primarily in Simulink. Currently, however, auto-coding Ramses into C++ requires 5 hours of code generation time. This causes issues if the tool ever needs to be debugged, as this code generation will need to occur with each edit to any part of

  15. Auto antibodies against oxidized low density lipoprotein in severe preeclampsia.

    Science.gov (United States)

    Jain, Meenakshi; Sawhney, Harjeet; Aggarwal, Neelam; Vashistha, Kala; Majumdhar, Siddarth

    2004-06-01

    To study autoantibody titres against oxidized low density lipoprotein in preeclamsia. Ten millimeters of heparinized blood samples were collected from 20 primigravidae with severe preeclamsia (study group) and 20 gestation-matched normotensive primigravidae (control group). Concentration of malondialdehyde, metabolite of lipid peroxidation were measured in sera by HPLC and autoantibodies against oxidized low density lipoproteins (obtained after oxidation with 2 mm CuSO(4)) were determined by ELISA. Statistical analysis was performed by Student's t-test and chi(2) test. Mean triglyceride levels were significantly (P /=1.32). In preeclamptic women, diastolic blood pressure, the amount of urinary protein excretion and the plasma level of urea were significantly higher (P < 0.05) in patients with higher auto antibody titre. Titres of autoantibodies to oxidized low density lipoprotein were similar in normotensive and preeclamptic women. In preeclamptic women, titres correlated positively with the severity of preeclampsia.

  16. Shape matters: improved flight in tapered auto-rotating wings

    Science.gov (United States)

    Liu, Yucen; Vincent, Lionel; Kanso, Eva

    2017-11-01

    Many plants use gravity and wind to disperse their seeds. The shape of seed pods influence their aerodynamics. For example, Liana seeds form aerodynamic gliders and Sycamore trees release airborne ``helicopters.'' Here, we use carefully-controlled experiments and high-speed photography to examine dispersion by tumbling (auto-rotation) and we focus on the effect of geometry on flight characteristics. We consider four families of shapes: rectangular, elliptic, tapered, and sharp-tip wings, and we vary the span-to-chord ratio. We find that tapered wings exhibit extended flight time and range, that is, better performance. A quasi-steady two-dimensional model is used to highlight the mechanisms by which shape affects flight performance. These findings could have significant implications on linking seedpod designs to seed dispersion patterns as well as on optimizing wing design in active flight problems.

  17. A Case control study of cardiovascular disease and arsenic exposure in Inner Mongolia, China

    Science.gov (United States)

    Background: Millions of people are at risk from the adverse effects of waterborne arsenic. Although the cardiovascular effects of high exposures to arsenic have been well documented, few individual level prospective studies have assessed cardiovascular risk at moderate exposures....

  18. TH-AB-202-04: Auto-Adaptive Margin Generation for MLC-Tracked Radiotherapy

    International Nuclear Information System (INIS)

    Glitzner, M; Lagendijk, J; Raaymakers, B; Crijns, S; Fast, M; Nill, S; Oelfke, U; Denis de Senneville, B

    2016-01-01

    Purpose: To develop an auto-adaptive margin generator for MLC tracking. The generator is able to estimate errors arising in image guided radiotherapy, particularly on an MR-Linac, which depend on the latencies of machine and image processing, as well as on patient motion characteristics. From the estimated error distribution, a segment margin is generated, able to compensate errors up to a user-defined confidence. Method: In every tracking control cycle (TCC, 40ms), the desired aperture D(t) is compared to the actual aperture A(t), a delayed and imperfect representation of D(t). Thus an error e(t)=A(T)-D(T) is measured every TCC. Applying kernel-density-estimation (KDE), the cumulative distribution (CDF) of e(t) is estimated. With CDF-confidence limits, upper and lower error limits are extracted for motion axes along and perpendicular leaf-travel direction and applied as margins. To test the dosimetric impact, two representative motion traces were extracted from fast liver-MRI (10Hz). The traces were applied onto a 4D-motion platform and continuously tracked by an Elekta Agility 160 MLC using an artificially imposed tracking delay. Gafchromic film was used to detect dose exposition for static, tracked, and error-compensated tracking cases. The margin generator was parameterized to cover 90% of all tracking errors. Dosimetric impact was rated by calculating the ratio between underexposed points (>5% underdosage) to the total number of points inside FWHM of static exposure. Results: Without imposing adaptive margins, tracking experiments showed a ratio of underexposed points of 17.5% and 14.3% for two motion cases with imaging delays of 200ms and 300ms, respectively. Activating the margin generated yielded total suppression (<1%) of underdosed points. Conclusion: We showed that auto-adaptive error compensation using machine error statistics is possible for MLC tracking. The error compensation margins are calculated on-line, without the need of assuming motion or

  19. Lead levels in some biological samples of auto-mechanics in Abeokuta, Nigeria.

    Science.gov (United States)

    Babalola, O O; Ojo, L O; Aderemi, M O

    2005-12-01

    Lead levels were determined in the blood, scalp hair and fingernails of 38, all male auto-mechanics (aged 18-45 years) from Abeokuta, South-western Nigeria. The subjects were classified into four sub-groups based on the period of exposure namely: 1-5, 6-10, 11-15, and >16 years. Thirty-two occupationally unexposed subjects (mainly office workers) served as the control. The weight, height and body mass indexes of all subjects were noted, in addition to other information obtained through structured questionnaire. The mean values of blood lead (BPb), hair lead (HPb) and fingernail lead (NPb) of the occupationally exposed subjects (n=38) were 48.50 +/- 9.08 microg/dL, 17.75 +/- 5.16 microg/g, and 5.92 +/- 3.30 microg/g respectively, while the corresponding mean values for these parameters in the control subjects (n = 32) were 33.(,5 +/- 10.09 microg/dL, 14.30 +/- 5.90 microg/g and 5.31 +/- 2.77 microg/g respectively. The differences in BPb and HPb levels of the two groups were statistically significant (P <0.05 and P <0.01 respectively), while that of NPb was not significant. The levels of lead in the biological samples appeared to have no relationship with the number of years on the job. From these results, it was obvious that the higher levels of lead in the biological samples of test subjects, compared with those of the controls were from environmental sources.

  20. Web proxy auto discovery for the WLCG

    CERN Document Server

    Dykstra, D; Blumenfeld, B; De Salvo, A; Dewhurst, A; Verguilov, V

    2017-01-01

    All four of the LHC experiments depend on web proxies (that is, squids) at each grid site to support software distribution by the CernVM FileSystem (CVMFS). CMS and ATLAS also use web proxies for conditions data distributed through the Frontier Distributed Database caching system. ATLAS & CMS each have their own methods for their grid jobs to find out which web proxies to use for Frontier at each site, and CVMFS has a third method. Those diverse methods limit usability and flexibility, particularly for opportunistic use cases, where an experiment’s jobs are run at sites that do not primarily support that experiment. This paper describes a new Worldwide LHC Computing Grid (WLCG) system for discovering the addresses of web proxies. The system is based on an internet standard called Web Proxy Auto Discovery (WPAD). WPAD is in turn based on another standard called Proxy Auto Configuration (PAC). Both the Frontier and CVMFS clients support this standard. The input into the WLCG system comes from squids regis...

  1. Auto-Generated Semantic Processing Services

    Science.gov (United States)

    Davis, Rodney; Hupf, Greg

    2009-01-01

    Auto-Generated Semantic Processing (AGSP) Services is a suite of software tools for automated generation of other computer programs, denoted cross-platform semantic adapters, that support interoperability of computer-based communication systems that utilize a variety of both new and legacy communication software running in a variety of operating- system/computer-hardware combinations. AGSP has numerous potential uses in military, space-exploration, and other government applications as well as in commercial telecommunications. The cross-platform semantic adapters take advantage of common features of computer- based communication systems to enforce semantics, messaging protocols, and standards of processing of streams of binary data to ensure integrity of data and consistency of meaning among interoperating systems. The auto-generation aspect of AGSP Services reduces development time and effort by emphasizing specification and minimizing implementation: In effect, the design, building, and debugging of software for effecting conversions among complex communication protocols, custom device mappings, and unique data-manipulation algorithms is replaced with metadata specifications that map to an abstract platform-independent communications model. AGSP Services is modular and has been shown to be easily integrable into new and legacy NASA flight and ground communication systems.

  2. Comparison of nested case-control and survival analysis methodologies for analysis of time-dependent exposure

    Directory of Open Access Journals (Sweden)

    Platt Robert W

    2005-01-01

    Full Text Available Abstract Background Epidemiological studies of exposures that vary with time require an additional level of methodological complexity to account for the time-dependence of exposure. This study compares a nested case-control approach for the study of time-dependent exposure with cohort analysis using Cox regression including time-dependent covariates. Methods A cohort of 1340 subjects with four fixed and seven time-dependent covariates was used for this study. Nested case-control analyses were repeated 100 times for each of 4, 8, 16, 32, and 64 controls per case, and point estimates were compared to those obtained using Cox regression on the full cohort. Computational efficiencies were evaluated by comparing central processing unit times required for analysis of the cohort at sizes 1, 2, 4, 8, 16, and 32 times its initial size. Results Nested case-control analyses yielded results that were similar to results of Cox regression on the full cohort. Cox regression was found to be 125 times slower than the nested case-control approach (using four controls per case. Conclusions The nested case-control approach is a useful alternative for cohort analysis when studying time-dependent exposures. Its superior computational efficiency may be particularly useful when studying rare outcomes in databases, where the ability to analyze larger sample sizes can improve the power of the study.

  3. Stressful working conditions and poor self-rated health among financial services employees Condiciones estresantes en el trabajo y peor auto evaluación de salud entre bancarios Condições estressantes no trabalho e pior auto avaliação de saúde entre bancários

    Directory of Open Access Journals (Sweden)

    Luiz Sérgio Silva

    2012-06-01

    Full Text Available OBJECTIVE: To assess the association between exposure to adverse psychosocial working conditions and poor self-rated health among bank employees. METHODS: A cross-sectional study including a sample of 2,054 employees of a government bank was conducted in 2008. Self-rated health was assessed by a single question: "In general, would you say your health is (...." Exposure to adverse psychosocial working conditions was evaluated by the effort-reward imbalance model and the demand-control model. Information on other independent variables was obtained through a self-administered semi-structured questionnaire. A multiple logistic regression analysis was performed and odds ratio calculated to assess independent associations between adverse psychosocial working conditions and poor self-rated health. RESULTS: The overall prevalence of poor self-rated health was 9%, with no significant gender difference. Exposure to high demand and low control environment at work was associated with poor self-rated health. Employees with high effort-reward imbalance and overcommitment also reported poor self-rated health, with a dose-response relationship. Social support at work was inversely related to poor self-rated health, with a dose-response relationship. CONCLUSIONS: Exposure to adverse psychosocial work factors assessed based on the effort-reward imbalance model and the demand-control model is independently associated with poor self-rated health among the workers studied.OBJETIVO: Analizar la asociación entre exposición a condiciones psicosociales adversas en el trabajo y evaluación mala de la salud entre bancarios. MÉTODO: Se realizó estudio transversal con 2.054 trabajadores de un banco estatal brasileño en 2008. Se utilizó una pregunta simple y directa: "En general, usted diría que su salud es" para chequear como ellos evalúan su estado de salud actual. Las condiciones psicosociales adversas en el trabajo fueron evaluadas por los modelos desequilibrio

  4. Case-control study on radon exposure and lung cancer in an Italian region. Preliminary results

    International Nuclear Information System (INIS)

    Bochicchio, F; Nuccetelli, C.; Forastiere, F.; Mallone, S.; Sera, F.

    2000-01-01

    The present estimates of the lung cancer risk for the general population due to radon exposure in dwellings are generally obtained by extrapolating the risk estimates derived from epidemiologic studies on miner cohorts. However, due to uncertainties related to this extrapolation, numerous case-control studies in Europe and North America were planned to estimate directly the risk in dwellings. Most of these studies are still underway and, thanks to their similar design and compatible protocols, it will be possible to perform a pooled analysis in order to improve statistical power. One of these projects is being conducted in the Lazio region of Italy, which is one of the Italian regions with the highest levels of radon indoors. A total of 408 cases and 424 controls older than 34 years, who lived for 25 years or longer in the Lazio Region, were recruited in a hospital of Rome. Detailed information regarding smoking, and occupational exposure of the subjects were collected by interviews in hospital. Residential histories (periods and addresses) during the 35 years preceding the enrolment were ascertained for all study members from the local Register and from a short questionnaire to the subjects or to the next-of-kin, resulting in 2068 dwellings to be monitored within the Lazio region. The distribution of the number of dwellings among cases and controls was the following: 25.7% of the cases and 27.3% of the controls had lived all the preceding 35 years in a single dwelling, whereas only a minority (7.9%) changed five addresses or more. The mean number of dwellings was very similar among cases (2.47) and controls (2.50). In each dwelling, radon dosemeters were placed in both the main bedroom and living room for two consecutive six-month periods. In the second six-month period, two thermoluminescent dosemeters were also collocated in each monitored room to measure gamma radiation emitted by the building materials, in order to evaluate more comprehensively the exposure of

  5. Economic evaluation of epinephrine auto-injectors for peanut allergy.

    Science.gov (United States)

    Shaker, Marcus; Bean, Katherine; Verdi, Marylee

    2017-08-01

    Three commercial epinephrine auto-injectors were available in the United States in the summer of 2016: EpiPen, Adrenaclick, and epinephrine injection, USP auto-injector. To describe the variation in pharmacy costs among epinephrine auto-injector devices in New England and evaluate the additional expense associated with incremental auto-injector costs. Decision analysis software was used to evaluate costs of the most and least expensive epinephrine auto-injector devices for children with peanut allergy. To evaluate regional variation in epinephrine auto-injector costs, a random sample of New England national and corporate pharmacies was compared with a convenience sample of pharmacies from 10 Canadian provinces. Assuming prescriptions written for 2 double epinephrine packs each year (home and school), the mean costs of food allergy over the 20-year model horizon totaled $58,667 (95% confidence interval [CI] $57,745-$59,588) when EpiPen was prescribed and $45,588 (95% CI $44,873-$46,304) when epinephrine injection, USP auto-injector was prescribed. No effectiveness differences were evident between groups, with 17.19 (95% CI 17.11-17.27) quality-adjusted life years accruing for each subject. The incremental cost per episode of anaphylaxis treated with epinephrine over the model horizon was $12,576 for EpiPen vs epinephrine injection, USP auto-injector. EpiPen costs were lowest at Canadian pharmacies ($96, 95% CI $85-$107). There was price consistency between corporate and independent pharmacies throughout New England by device brand, with the epinephrine injection, USP auto-injector being the most affordable device. Cost differences among epinephrine auto-injectors were significant. More expensive auto-injector brands did not appear to provide incremental benefit. Copyright © 2017 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.

  6. Gene expression profiling in persons with multiple chemical sensitivity before and after a controlled n-butanol exposure session

    DEFF Research Database (Denmark)

    Dantoft, Thomas Meinertz; Skovbjerg, Sine; Andersson, Linus

    2017-01-01

    in a windowed exposure chamber for 60 min. A total of 26 genes involved in biochemical pathways found in the literature have been proposed to play a role in the pathogenesis of MCS and other functional somatic syndromes were selected. Expression levels were compared between MCS and controls before, within 15...... min after being exposed to and 4 hours after the exposure. Participants suffering from MCS and healthy controls were recruited through advertisement at public places and in a local newspaper. 36 participants who considered themselves sensitive were prescreened for eligibility. 18 sensitive persons......To investigate the pathophysiological pathways leading to symptoms elicitation in multiple chemical sensitivity (MCS) by comparing gene expression in MCS participants and healthy controls before and after a chemical exposure optimised to cause symptoms among MCS participants.The first hypothesis...

  7. Toxoplasma gondii exposure and Parkinson's disease: a case–control study

    Science.gov (United States)

    Alvarado-Esquivel, Cosme; Méndez-Hernández, Edna Madai; Salas-Pacheco, José Manuel; Ruano-Calderón, Luis Ángel; Hernández-Tinoco, Jesús; Arias-Carrión, Oscar; Sánchez-Anguiano, Luis Francisco; Castellanos-Juárez, Francisco Xavier; Sandoval-Carrillo, Ada Agustina; Liesenfeld, Oliver; Ramos-Nevárez, Agar

    2017-01-01

    Objectives To determine the association between Toxoplasma gondii infection and Parkinson's disease and to investigate whether T. gondii seropositivity is associated with the general characteristics of patients with Parkinson's disease. Design Case–control study. Setting Cases and controls were enrolled in Durango City, Mexico. Participants 65 patients with Parkinson's disease and 195 age- and gender-matched control subjects without Parkinson's disease. Primary and secondary outcome measures Serum samples of participants were analysed for anti-T. gondii IgG and IgM antibodies by commercially available enzyme-linked immunoassays. Prevalence of T. gondii DNA was determined in seropositive subjects using PCR. The association between clinical data and infection was examined by bivariate analysis. Results Anti-T. gondii IgG antibodies were found in 6/65 cases (9.2%) and in 21/195 controls (10.8%) (OR 0.84; 95% CI 0.32 to 2.18; p=0.81). The frequency of high (>150 IU/mL) antibody levels was similar among cases and controls (p=0.34). None of the anti-T. gondii IgG positive cases and four of the anti-T. gondii IgG positive controls had anti-T. gondii IgM antibodies (p=0.54). The prevalence of T. gondii DNA was comparable in seropositive cases and controls (16.7% and 25%, respectively; p=1.0). Seroprevalence of T. gondii infection was associated with a young age onset of disease (p=0.03), high Unified Parkinson Disease Rating Scale scores (p=0.04) and depression (p=0.02). Seropositivity to T. gondii infection was lower in patients treated with pramipexole than in patients without this treatment (p=0.01). However, none of the associations remained significant after Bonferroni correction. Conclusions The results do not support an association between T. gondii infection and Parkinson's disease. However, T. gondii infection might have an influence on certain symptoms of Parkinson's disease. Further research to elucidate the role of T. gondii exposure on Parkinson's disease

  8. Community Violence Exposure and Conduct Problems in Children and Adolescents with Conduct Disorder and Healthy Controls.

    Science.gov (United States)

    Kersten, Linda; Vriends, Noortje; Steppan, Martin; Raschle, Nora M; Praetzlich, Martin; Oldenhof, Helena; Vermeiren, Robert; Jansen, Lucres; Ackermann, Katharina; Bernhard, Anka; Martinelli, Anne; Gonzalez-Madruga, Karen; Puzzo, Ignazio; Wells, Amy; Rogers, Jack C; Clanton, Roberta; Baker, Rosalind H; Grisley, Liam; Baumann, Sarah; Gundlach, Malou; Kohls, Gregor; Gonzalez-Torres, Miguel A; Sesma-Pardo, Eva; Dochnal, Roberta; Lazaratou, Helen; Kalogerakis, Zacharias; Bigorra Gualba, Aitana; Smaragdi, Areti; Siklósi, Réka; Dikeos, Dimitris; Hervás, Amaia; Fernández-Rivas, Aranzazu; De Brito, Stephane A; Konrad, Kerstin; Herpertz-Dahlmann, Beate; Fairchild, Graeme; Freitag, Christine M; Popma, Arne; Kieser, Meinhard; Stadler, Christina

    2017-01-01

    Exposure to community violence through witnessing or being directly victimized has been associated with conduct problems in a range of studies. However, the relationship between community violence exposure (CVE) and conduct problems has never been studied separately in healthy individuals and individuals with conduct disorder (CD). Therefore, it is not clear whether the association between CVE and conduct problems is due to confounding factors, because those with high conduct problems also tend to live in more violent neighborhoods, i.e., an ecological fallacy. Hence, the aim of the present study was: (1) to investigate whether the association between recent CVE and current conduct problems holds true for healthy controls as well as adolescents with a diagnosis of CD; (2) to examine whether the association is stable in both groups when including effects of aggression subtypes (proactive/reactive aggression), age, gender, site and socioeconomic status (SES); and (3) to test whether proactive or reactive aggression mediate the link between CVE and conduct problems. Data from 1178 children and adolescents (62% female; 44% CD) aged between 9 years and 18 years from seven European countries were analyzed. Conduct problems were assessed using the Kiddie-Schedule of Affective Disorders and Schizophrenia diagnostic interview. Information about CVE and aggression subtypes was obtained using self-report questionnaires (Social and Health Assessment and Reactive-Proactive aggression Questionnaire (RPQ), respectively). The association between witnessing community violence and conduct problems was significant in both groups (adolescents with CD and healthy controls). The association was also stable after examining the mediating effects of aggression subtypes while including moderating effects of age, gender and SES and controlling for effects of site in both groups. There were no clear differences between the groups in the strength of the association between witnessing violence

  9. Community Violence Exposure and Conduct Problems in Children and Adolescents with Conduct Disorder and Healthy Controls

    Directory of Open Access Journals (Sweden)

    Linda Kersten

    2017-11-01

    Full Text Available Exposure to community violence through witnessing or being directly victimized has been associated with conduct problems in a range of studies. However, the relationship between community violence exposure (CVE and conduct problems has never been studied separately in healthy individuals and individuals with conduct disorder (CD. Therefore, it is not clear whether the association between CVE and conduct problems is due to confounding factors, because those with high conduct problems also tend to live in more violent neighborhoods, i.e., an ecological fallacy. Hence, the aim of the present study was: (1 to investigate whether the association between recent CVE and current conduct problems holds true for healthy controls as well as adolescents with a diagnosis of CD; (2 to examine whether the association is stable in both groups when including effects of aggression subtypes (proactive/reactive aggression, age, gender, site and socioeconomic status (SES; and (3 to test whether proactive or reactive aggression mediate the link between CVE and conduct problems. Data from 1178 children and adolescents (62% female; 44% CD aged between 9 years and 18 years from seven European countries were analyzed. Conduct problems were assessed using the Kiddie-Schedule of Affective Disorders and Schizophrenia diagnostic interview. Information about CVE and aggression subtypes was obtained using self-report questionnaires (Social and Health Assessment and Reactive-Proactive aggression Questionnaire (RPQ, respectively. The association between witnessing community violence and conduct problems was significant in both groups (adolescents with CD and healthy controls. The association was also stable after examining the mediating effects of aggression subtypes while including moderating effects of age, gender and SES and controlling for effects of site in both groups. There were no clear differences between the groups in the strength of the association between witnessing

  10. Characteristics of acute occupational pesticide exposures reported to poison control centers in Texas, 2000-2015.

    Science.gov (United States)

    Trueblood, Amber B; Shipp, Eva M

    2017-06-12

    In the United States, there is limited literature on occupational pesticide exposures despite being associated with adverse health outcomes, including in large states such as Texas. The purpose of this article is to characterize occupational pesticide poison center exposures in Texas. Descriptive statistics were used to describe exposures (eg, exposure routes, type of pesticide, medical outcome, clinical effects, and temporal/seasonal patterns). From 2000 to 2015, there were 2,303 occupational pesticide poison center exposures. Common types of reported pesticides were insecticides (67.3%), herbicides (17.7%), and repellents (5.8%). The highest proportion of exposures were among those aged 20 to 29 years (24.9%). The top clinical effect categories were gastrointestinal (25.8%), neurological (19.2%), and dermal (14.9%). Characterizing occupational pesticide poison center exposures can support improved surveillance systems and guide future research or interventions.

  11. Open loop, auto reversing liquid nitrogen circulation thermal system for thermo vacuum chamber

    International Nuclear Information System (INIS)

    Naidu, M C A; Nolakha, Dinesh; Saharkar, B S; Kavani, K M; Patel, D R

    2012-01-01

    In a thermo vacuum chamber, attaining and controlling low and high temperatures (-100 Deg. C to +120 Deg. C) is a very important task. This paper describes the development of 'Open loop, auto reversing liquid nitrogen based thermal system'. System specifications, features, open loop auto reversing system, liquid nitrogen flow paths etc. are discussed in this paper. This thermal system consists of solenoid operated cryogenic valves, double embossed thermal plate (shroud), heating elements, temperature sensors and PLC. Bulky items like blowers, heating chambers, liquid nitrogen injection chambers, huge pipe lines and valves were not used. This entire thermal system is very simple to operate and PLC based, fully auto system with auto tuned to given set temperatures. This system requires a very nominal amount of liquid nitrogen (approx. 80 liters / hour) while conducting thermo vacuum tests. This system was integrated to 1.2m dia thermo vacuum chamber, as a part of its augmentation, to conduct extreme temperature cycling tests on passive antenna reflectors of satellites.

  12. [PSYCHOTHERAPEUTIC INTERVENTIONS IN PATIENTS WITH AUTO-AGGRESSIVE BEHAVIOR DURING THE FIRST PSYCHOTIC EPISODE].

    Science.gov (United States)

    Mudrenko, I; Potapov, A; Sotnikov, D; Kolenko, O; Kmyta, A

    2017-09-01

    In this article the formation of psychopathological predictors auto-aggressive behavior in patients with a first psychotic episode were identified, which became "targets" in the framework of a comprehensive emergency suicide assistance to conduct the crisis psychotherapy. The work was done on the basis of the Sumy regional psychoneurologic dispensary, where 100 patients with a first psychotic episode were examined: 52 of them (core group) had suicidal symptoms and 48 (control group) had not. According to the test results of severity of auto-aggressive predictors (pre-suicidal syndrome) to clinicopsychopathological predictors of auto-aggressive behavior include: the narrowing of the cognitive function (p≤0,001), the avoidance of interpersonal contact (r≤0,001), the presence of affective (p≤0,001) and vegetative (p≤0,01) violations, the autoaggression of moderate severity (p≤0,001) and impulsivity (p≤0,001). Patients of the core group with the auto-aggressive behavior (n=58) completed a course of a crisis psychotherapy comprising the stages of crisis support, crisis intervention and increase the adaptation layer. After a psychotherapy course levels of aggression (6,45±0,41), auto-aggression (of 9,68±0,67), disorders in the affective sphere (18,58±0,66) and impulsivity (of 4,23±0,30) decreased, which was manifested in increasing tolerance to emotional stress factors, control over their emotions and reduce their affective valence (p≤0,001). The expansion of interpersonal interaction, the increase of patients social activity, the blood relationships establishment (of 9,23±0,40) was observed.

  13. Exposure-dependent control of malaria-induced inflammation in children.

    Science.gov (United States)

    Portugal, Silvia; Moebius, Jacqueline; Skinner, Jeff; Doumbo, Safiatou; Doumtabe, Didier; Kone, Younoussou; Dia, Seydou; Kanakabandi, Kishore; Sturdevant, Daniel E; Virtaneva, Kimmo; Porcella, Stephen F; Li, Shanping; Doumbo, Ogobara K; Kayentao, Kassoum; Ongoiba, Aissata; Traore, Boubacar; Crompton, Peter D

    2014-04-01

    In malaria-naïve individuals, Plasmodium falciparum infection results in high levels of parasite-infected red blood cells (iRBCs) that trigger systemic inflammation and fever. Conversely, individuals in endemic areas who are repeatedly infected are often asymptomatic and have low levels of iRBCs, even young children. We hypothesized that febrile malaria alters the immune system such that P. falciparum re-exposure results in reduced production of pro-inflammatory cytokines/chemokines and enhanced anti-parasite effector responses compared to responses induced before malaria. To test this hypothesis we used a systems biology approach to analyze PBMCs sampled from healthy children before the six-month malaria season and the same children seven days after treatment of their first febrile malaria episode of the ensuing season. PBMCs were stimulated with iRBC in vitro and various immune parameters were measured. Before the malaria season, children's immune cells responded to iRBCs by producing pro-inflammatory mediators such as IL-1β, IL-6 and IL-8. Following malaria there was a marked shift in the response to iRBCs with the same children's immune cells producing lower levels of pro-inflammatory cytokines and higher levels of anti-inflammatory cytokines (IL-10, TGF-β). In addition, molecules involved in phagocytosis and activation of adaptive immunity were upregulated after malaria as compared to before. This shift was accompanied by an increase in P. falciparum-specific CD4+Foxp3- T cells that co-produce IL-10, IFN-γ and TNF; however, after the subsequent six-month dry season, a period of markedly reduced malaria transmission, P. falciparum-inducible IL-10 production remained partially upregulated only in children with persistent asymptomatic infections. These findings suggest that in the face of P. falciparum re-exposure, children acquire exposure-dependent P. falciparum-specific immunoregulatory responses that dampen pathogenic inflammation while enhancing anti

  14. Radiation exposure control of nuclear power plant personnel in the Federal Republic of Germany

    International Nuclear Information System (INIS)

    Mehl, J.

    1980-01-01

    The analysis of exposure records of all persons engaged in radiation work at nuclear power plants of the Federal Republic of Germany has shown that annual collective doses increase rapidly with time. The annual gross electrical energy generated from nuclear power also increases rapidly with time, corresponding to about 11% of the total gross electrical energy produced in 1977/78. Therefore, it is obvious that there is an increase of both the risk and the benefit from nuclear power production. Whether in the course of time the situation develops more towards the risk or the benefit side is learned from the history of the annual ratio of the collective dose per gross electrical energy generated. This ratio shows a significant decrease since 1972. The decrease is due to the experience gained from operation of the first-generation plants, which led to several administrative measures aimed at an improved control of the collective doses of power plant personnel in the Federal Republic of Germany. The administrative measures include, among others, the introduction of the following requirements: (a) Everyone who applies for a nuclear power plant construction licence has to provide evidence that, in the design of the plant, full use is made of the experience gained from plants in operation with respect to reduction of collective doses of the power plant personnel. (b) Everyone who engages his employees on radiation work within operations for which an operation licence is required, but which is held by others, requires a special 'contractor licence'. (c) Every person engaged in radiation work on the basis of a contractor licence must carry a special exposure record book which is registered by the competent national authority. (author)

  15. Positive enteric contrast material for abdominal and pelvic CT with automatic exposure control: What is the effect on patient radiation exposure?

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Zhen J., E-mail: jane.wang@radiology.ucsf.edu [Department of Radiology, University of California San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143-0628 (United States); Chen, Katherine S.; Gould, Robert; Coakley, Fergus V.; Fu Yanjun; Yeh, Benjamin M. [Department of Radiology, University of California San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143-0628 (United States)

    2011-08-15

    Objective: To assess the effect of positive enteric contrast administration on automatic exposure control (AEC) CT radiation exposure in (1) a CT phantom, and (2) a retrospective review of patients. Materials and methods: We scanned a CT phantom containing simulated bowel that was sequentially filled with water and positive enteric contrast, and recorded the mean volume CT dose index (CTDIvol). We also identified 17 patients who had undergone 2 technically comparable CT scans of the abdomen and pelvis, one with positive enteric contrast and the other with oral water. Paired Student's t-tests were used to compare the mean CTDIvol between scans performed with and without positive enteric contrast. Both the phantom and patient CT scans were performed using AEC with a fixed noise index. Results: The mean CTDIvol for the phantom with simulated bowel containing water and positive enteric contrast were 8.2 {+-} 0.2 mGy, and 8.7 {+-} 0.1 mGy (6.1% higher than water, p = 0.02), respectively. The mean CTDIvol for patients scanned with oral water and with positive enteric contrast were 11.8 mGy and 13.1 mGy, respectively (p = 0.003). This corresponded to a mean CTDIvol which was 11.0% higher (range: 0.0-20.7% higher) in scans with positive enteric contrast than those with oral water in patients. Conclusions: When automatic exposure control is utilized for abdominopelvic CT, the radiation exposure, as measured by CTDIvol, is higher for scans performed with positive enteric contrast than those with oral water.

  16. Allergy arising from exposure to airborne contaminants in an insect rearing facility: Health effects and exposure control

    Energy Technology Data Exchange (ETDEWEB)

    Wolff, D.

    1994-06-01

    In agricultural crop improvement, yield under various stress conditions and limiting factors is assessed experimentally. Of the stresses on plants which affect yield are those due to insects. Ostrinia nubilalis, the European corn borer (corn borer) is a major pest in sweet and field corn in the U.S. There are many ways to fight crop pests such as the corn borer, including (1) application of chemical insecticides, (2) application of natural predators and, (3) improving crop resistance through plant genetics programs. Randomized field trials are used to determine the effectiveness of pest management programs. These trials frequently consist of randomly selected crop plots to which well-defined input regimes are instituted. For example, corn borers might be released onto crop plots in several densities at various stages of crop development, then sprayed with different levels of pesticide. These experiments are duplicated across regions and, in some cases across the country, to determine, in this instance for example, the best pesticide application rate for a given pest density and crop development stage. In order to release these pests onto crop plots, one must have an adequate supply of the insect pest. In winter months studies are carried out in the laboratory to examine chemical and natural pesticide effectiveness, as well as such things as the role of pheromones in moth behavior. The advantage in field trials is that yield data can be garnered directly. In this country, insects are raised for crop research primarily through the US Department of Agriculture, in cooperation with public Land Grant Universities and, by the private sector agricultural concerns - seed companies and others. This study quantifies the airborne allergen exposure of persons working in a Land Grant University entomology lab were allergy to European corn borer was suspected.

  17. Auto-ionizing states in MgI

    International Nuclear Information System (INIS)

    El-Sherbini, Th.M.; Rahman, A.A.

    1982-01-01

    Hartree-Fock calculations have been performed for the auto-ionizing levels of the 3pns, 3pnp, 4snp (n=4 to 7) and 3pnd (n=3 to 7) series in MgI. The calculated energies of the auto-ionizing states are compared with the available results from photo-absorption measurements and ejected-electron experiments. (author)

  18. Auto-immune encefalitis in de psychiatrische praktijk

    NARCIS (Netherlands)

    de Witte, L; Kromkamp, M|info:eu-repo/dai/nl/241613876; Schoenmaker, N; van Mierlo, H C|info:eu-repo/dai/nl/413967263; Martinez-Martínez, P; Palmen, S J M; Sommer, I E C|info:eu-repo/dai/nl/258791519

    BACKGROUND: Our knowledge about auto-immune limbic encephalitis is increasing rapidly and it is now evident that patients with this disease can present with psychiatric symptoms. AIM: To propose practical guidelines for the recognition and diagnosis of an underlying auto-immune limbic encephalitis

  19. Kommest Auto ostmisest huvitub ka Hillar Teder / Andres Eilart

    Index Scriptorium Estoniae

    Eilart, Andres

    2008-01-01

    Kommest Auto ostmise vastu tunnevad huvi suurärimees Andres Sarri, Rootsis Peugeot' sõidukeid müüv Taani päritolu K. W. Bruun Import ja multimiljonär Hillar Teder, kellele kuulub Audisid müüv Reval Auto

  20. Sarri võttis Talleksiga taanlastelt Saksa Auto / Villy Paimets

    Index Scriptorium Estoniae

    Paimets, Villy, 1972-

    2005-01-01

    Andres Sarri poolt kontrollitav AS Talleks ostis Taani partnerilt Semler Holding välja 50-protsendilise osaluse AS-is Saksa Auto. Lisa: Viimastel aastatel eestlaste poolt välja ostetud ettevõtted. Diagramm: Saksa Auto tulemused paranesid mullu märgatavalt. Vt. samas: Sarri: me ei tee halbu tehinguid; Peeter Raidla. Tuleristsed 90ndate alguse võimuvõitlusest

  1. Rüütmann taandub Kommest Auto juhtimisest / Kaisa Tahlfeld

    Index Scriptorium Estoniae

    Tahlfeld, Kaisa

    2007-01-01

    AS-i Kommest Auto asutaja ja omanik Toomas Rüütmann loobub ettevõtte juhtimisest, kuid jätkab juhatuse liikmena ning keskendub eksportturgudele ja koostööle edasimüüjatega. Kommest Auto uueks juhiks saab Raido Toonekurg. Lisa: Mis on mis; Taust

  2. Auto concept y rasgos de personalidad: Un estudio correlacional

    Directory of Open Access Journals (Sweden)

    Débora Cecílio Fernandes

    Full Text Available Este estudio ha investigado las relaciones entre los rasgos de personalidad y auto concepto. Fueron aplicadas la Escala de Traços de Personalidade para Crianças y la Escala de Autoconceito Infanto-Juvenil en 389 niños, con edad de 8 a 10 años de escuelas públicas y particulares. Se han hallado diferencias de sexo para casi todas las medidas hechas. Para los varones, ha sido observado correlaciones positivas entre extroversión y auto conceptos escolar y familiar, neuroticismo y psicoticismo con auto conceptos personal y social, y sociabilidad con auto concepto familiar; y correlaciones negativas entre extroversión y auto concepto social, psicoticismo y auto concepto familiar, y sociabilidad y auto concepto personal. Para las niñas, fueron observadas correlaciones positivas entre el auto concepto social y psicoticismo y sociabilidad con el familiar; y correlaciones negativas entre extroversión y el social, psicoticismo y neuroticismo con el familiar. Los análisis de los grupos extremos confirmaron los datos encontrados.

  3. Auto-correlation analysis of ocean surface wind vectors

    Indian Academy of Sciences (India)

    M. Senthilkumar (Newgen Imaging) 1461 1996 Oct 15 13:05:22

    In this work, an auto-correlation analysis of a time series data of surface winds measured in situ by a deep water buoy in the Indian Ocean has been carried out. Hourly time series data available for 240 hours in the month of May, 1999 were subjected to an auto-correlation analysis. The analysis indicates an exponential fall ...

  4. 46 CFR 122.360 - Use of auto pilot.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Use of auto pilot. 122.360 Section 122.360 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS CARRYING MORE THAN 150... Requirements § 122.360 Use of auto pilot. Whenever an automatic pilot is used the master shall ensure that: (a...

  5. 46 CFR 167.65-35 - Use of auto pilot.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Use of auto pilot. 167.65-35 Section 167.65-35 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) NAUTICAL SCHOOLS PUBLIC NAUTICAL SCHOOL SHIPS Special Operating Requirements § 167.65-35 Use of auto pilot. Except as provided in 33 CFR 164.15, when...

  6. 46 CFR 109.585 - Use of auto pilot.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Use of auto pilot. 109.585 Section 109.585 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) A-MOBILE OFFSHORE DRILLING UNITS OPERATIONS Miscellaneous § 109.585 Use of auto pilot. Except as provided in 33 CFR 164.15, when the automatic pilot is used...

  7. 46 CFR 185.360 - Use of auto pilot.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Use of auto pilot. 185.360 Section 185.360 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS (UNDER 100 GROSS TONS) OPERATIONS Miscellaneous Operating Requirements § 185.360 Use of auto pilot. Whenever an automatic pilot is...

  8. 46 CFR 131.960 - Use of auto-pilot.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Use of auto-pilot. 131.960 Section 131.960 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OFFSHORE SUPPLY VESSELS OPERATIONS Miscellaneous § 131.960 Use of auto-pilot. When the automatic pilot is used in areas of high traffic density...

  9. Differential Immuno-Reactivity to Genomic DNA, RNA and Mitochondrial DNA is Associated with Auto-Immunity

    Directory of Open Access Journals (Sweden)

    Vilena V. Ivanova

    2014-12-01

    Full Text Available Background: Circulating auto-reactive antibodies are hallmark features of auto-immune diseases, however little is known with respect to the specificity of such bio-markers. In the present study, we investigated the specificity of anti-nucleic acid antibodies in the blood of subjects with systemic lupus erythematosus (SLE and healthy controls. Methods: Sera from 12 SLE cases and 8 controls were evaluated for immuno-reactivity to purified RNA, DNA and mitochondrial DNA (mtDNA by enzyme-linked immuno-sorbent assay (ELISA. Results: As expected, immuno-reactivity to total nucleic acids was significantly higher in subjects with SLE when compared to healthy controls, however a clear distinction was observed among the various nucleic acid sub-types, with sera from SLE subjects displaying the greatest immuno-reactivity to RNA followed by mtDNA and then total DNA. Conclusion: The identification of auto-reactive antibodies can serve as highly sensitive biomarkers, although their specificity may not always allow diagnostic certainty. The knowledge that auto-antibodies in subjects with SLE display differential immuno-reactivity may help to improve existing diagnostics and may lead to a better understanding of the pathogenesis of auto-immune disorders.

  10. Childhood physical abnormalities following paternal exposure to sulfur mustard gas in Iran: a case-control study

    Directory of Open Access Journals (Sweden)

    Khademolhosseini Seyyed M

    2010-07-01

    Full Text Available Abstract Background Mustard gas, a known chemical weapon, was used during the Iran-Iraq war of 1980-1988. We aimed to determine if exposure to mustard gas among men was significantly associated with abnormalities and disorders among progenies. Methods Using a case-control design, we identified all progenies of Sardasht men (exposed group, n = 498, who were born at least nine months after the exposure, compared to age-matched controls in Rabat, a nearby city (non-exposed group, n = 689. We conducted a thorough medical history, physical examination, and appropriate paraclinical studies to detect any physical abnormality and/or disorder. Given the presence of correlated data, we applied Generalized Estimating Equation (GEE multivariable models to determine associations. Results The overall frequency of detected physical abnormalities and disorders was significantly higher in the exposed group (19% vs. 11%, Odds Ratio [OR] 1.93, 95% Confidence Interval [CI], 1.37-2.72, P = 0.0002. This was consistent across sexes. Congenital anomalies (OR 3.54, 95% CI, 1.58-7.93, P = 0.002 and asthma (OR, 3.12, 95% CI, 1.43-6.80, P = 0.004 were most commonly associated with exposure. No single abnormality was associated with paternal exposure to mustard gas. Conclusion Our study demonstrates a generational effect of exposure to mustard gas. The lasting effects of mustard gas exposure in parents effects fertility and may impact child health and development in the long-term.

  11. Low auto-fluorescence fabrication methods for plastic nanoslits.

    Science.gov (United States)

    Yin, Zhifu; Qi, Liping; Zou, Helin; Sun, Lei; Xu, Shenbo

    2016-04-01

    Plastic nanofluidic devices are becoming increasingly important for biological and chemical applications. However, they suffer from high auto-fluorescence when used for on-chip optical detection. In this study, the auto-fluorescence problem of plastic nanofluidic devices was remedied by newly developed fabrication methods that minimise their auto-fluorescence: one by depositing a gold (Au) layer on them, the other by making them ultra-thin. In the first method, the Au layer [minimum thickness is 40 nm on 150 μm SU-8, 50 nm on 1 mm polyethylene terephthalate (PET), and 40 on 2 nm polymethyl methacrylate (PMMA)] blocks the auto-fluorescence of the polymer; in the second method, auto-fluorescence is minimised by making the chips ultra-thin, selected operating thickness of SU-8 is 20 μm, for PET it is 150 μm, and for PMMA it is 0.8 mm.

  12. Mortality studies of metalworking fluid exposure in the automobile industry: VI. A case-control study of esophageal cancer.

    Science.gov (United States)

    Sullivan, P A; Eisen, E A; Woskie, S R; Kriebel, D; Wegman, D H; Hallock, M F; Hammond, S K; Tolbert, P E; Smith, T J; Monson, R R

    1998-07-01

    Results are reported from a nested case-control study of 60 esophageal cancer deaths among 46,384 automobile manufacturing workers potentially exposed to metalworking fluids (MWF) in machining and grinding operations. By using incidence-density sampling, controls were selected with a sampling ratio of 20:1 from among co-workers who remained at risk by the age of death of the case, matched on race, gender, plant, and year of birth. Conditional logistic regression was used to evaluate the risk associated with cumulative exposure (mg/m3-years) to each of three types of metalworking fluid (straight, soluble, and synthetic MWF), as well as with years of exposure to selected components of MWF, including nitrosamines, sulfur, biocides, and several metals. Esophageal cancer was found to be significantly associated with exposure to both soluble and synthetic MWF in grinding operations. The odds ratios (ORs) for grinding with soluble MWF were elevated at 2.5 or greater in all categories of cumulative exposure, although the exposure-response trend was statistically significant only when exposure was measured as duration. Those with 12 or more years exposure to soluble MWF in grinding operations experienced a 9.3-fold relative risk of esophageal cancer mortality (95% CI = 2.1-42.1). The OR for ever grinding with synthetic MWF was 4.1 (95% CI = 1.1-15.0). Elevated risk was also associated with two agents found in both synthetic and soluble fluids, nitrosamines, and biocides. For exposure to nitrosamines, the OR was 5.4 (95% CI = 1.5-19.9); for biocides the OR was 3.8 (95% CI = 0.8-18.9). However, because the same workers were exposed to grinding with synthetics, nitrosamines and biocides, it was not possible to separate the specific risks associated with these components.

  13. A dose-controlled system for air-liquid interface cell exposure and application to zinc oxide nanoparticles

    Directory of Open Access Journals (Sweden)

    Ferron George A

    2009-12-01

    Full Text Available Abstract Background Engineered nanoparticles are becoming increasingly ubiquitous and their toxicological effects on human health, as well as on the ecosystem, have become a concern. Since initial contact with nanoparticles occurs at the epithelium in the lungs (or skin, or eyes, in vitro cell studies with nanoparticles require dose-controlled systems for delivery of nanoparticles to epithelial cells cultured at the air-liquid interface. Results A novel air-liquid interface cell exposure system (ALICE for nanoparticles in liquids is presented and validated. The ALICE generates a dense cloud of droplets with a vibrating membrane nebulizer and utilizes combined cloud settling and single particle sedimentation for fast (~10 min; entire exposure, repeatable (2. The cell-specific deposition efficiency is currently limited to 0.072 (7.2% for two commercially available 6-er transwell plates, but a deposition efficiency of up to 0.57 (57% is possible for better cell coverage of the exposure chamber. Dose-response measurements with ZnO nanoparticles (0.3-8.5 μg/cm2 showed significant differences in mRNA expression of pro-inflammatory (IL-8 and oxidative stress (HO-1 markers when comparing submerged and air-liquid interface exposures. Both exposure methods showed no cellular response below 1 μg/cm2 ZnO, which indicates that ZnO nanoparticles are not toxic at occupationally allowed exposure levels. Conclusion The ALICE is a useful tool for dose-controlled nanoparticle (or solute exposure of cells at the air-liquid interface. Significant differences between cellular response after ZnO nanoparticle exposure under submerged and air-liquid interface conditions suggest that pharmaceutical and toxicological studies with inhaled (nano-particles should be performed under the more realistic air-liquid interface, rather than submerged cell conditions.

  14. Female Infertility and Serum Auto-antibodies: a Systematic Review.

    Science.gov (United States)

    Deroux, Alban; Dumestre-Perard, Chantal; Dunand-Faure, Camille; Bouillet, Laurence; Hoffmann, Pascale

    2017-08-01

    On average, 10 % of infertile couples have unexplained infertility. Auto-immune disease (systemic lupus erythematosus, anti-phospholipid syndrome) accounts for a part of these cases. In the last 20 years, aspecific auto-immunity, defined as positivity of auto-antibodies in blood sample without clinical or biological criteria for defined diseases, has been evoked in a subpopulation of infertile women. A systematic review was performed (PUBMED) using the MESH search terms "infertility" and "auto-immunity" or "reproductive technique" or "assisted reproduction" or "in vitro fertilization" and "auto-immunity." We retained clinical and physiopathological studies that were applicable to the clinician in assuming joint management of both infertility associated with serum auto-antibodies in women. Thyroid auto-immunity which affects thyroid function could be a cause of infertility; even in euthyroidia, the presence of anti-thyroperoxydase antibodies and/or thyroglobulin are related to infertility. The presence of anti-phospholipid (APL) and/or anti-nuclear (ANA) antibodies seems to be more frequent in the population of infertile women; serum auto-antibodies are associated with early ovarian failure, itself responsible for fertility disorders. However, there exist few publications on this topic. The methods of dosage, as well as the clinical criteria of unexplained infertility deserve to be standardized to allow a precise response to the question of the role of serum auto-antibodies in these women. The direct pathogenesis of this auto-immunity is unknown, but therapeutic immunomodulators, prescribed on a case-by-case basis, could favor pregnancy even in cases of unexplained primary or secondary infertility.

  15. Gasification characteristics of auto shredder residue

    International Nuclear Information System (INIS)

    Navee, S.; Ramzan, N.

    2011-01-01

    Given the large volume of used tyre waste generated each year it is imperative that suitable re-use and disposal techniques are developed for dealing with this problem; presently these include rethreading, reprocessing for use as safe playground and sports surfaces, use as noise reduction barriers and utilisation as a fuel source. This paper reports on pilot scale studies designed to investigate the suitability of automotive waste for energy recovery via gasification. The study was carried out into auto shredder residue, which is a mixture of three distinct waste streams: tyres, rubber/plastic and general automotive waste. The tests included proximate, ultimate and elemental analysis, TGA, as well as calorific value determinations. In addition, the waste was tested in a desktop gasifier, and analysis was carried out to determine the presence and type of combustible gases. It was concluded that tyre waste and rubber/plastic waste are quite suitable fuels for gasification. (author)

  16. Auto-choreography: Animating Sentient Archives

    Directory of Open Access Journals (Sweden)

    Kim Satchell

    2010-03-01

    Full Text Available The stories lives tell, the narratives they follow and the spaces they embody are critical to articulating the conditions of everyday life. This resonates in the fraught relations within and between surf cultures, affluent societies and economic development. In the context of Rural Cultural Studies the analysis of coastal place allows for a combination of self-reflexive, critical and transformative modes of inquiry. This pedagogy of the coast offers innovative approaches to contemporary anthropogenic and existential challenges. For the Ecological Humanities, adjusting to living synergistically requires dialogue, ethical frameworks and care. This includes attention to the more-than human world and the non-human inhabitants with whose lives people become entangled in the mutuality of wandering paths and shared haunts. The imaginary-material architectures and geographies of these samples of coastal life, are topographies woven of spatiality and contemporary coastal writing. These contemplations attempt to sketch performative interactions from the auto-choreography animating sentient archives.

  17. Auto-Gerontology: A Personal Odyssey.

    Science.gov (United States)

    Palmore, Erdman B

    2017-11-01

    The four leading theories of optimal aging are activity, continuity, successful aging, and selective optimization with adaptation. All tend to support the slogan, "Use it or lose it." I have tried to continue using my abilities in four key areas: professional, volunteer, personal relationships, and physical fitness. Ageism also has become personal for me because I have made it a personal priority to do what I can to reduce ageism. This includes research and writing, developing a list of 45 advantages to aging, avoiding ageist jokes and language, developing positive slogans about aging, maintaining personal fitness, going on birthday adventures, and being proud of my age (85). I close with answers to some questions about auto-gerontology.

  18. A case-control study of occupational exposure to metalworking fluids and bladder cancer risk among men.

    Science.gov (United States)

    Colt, Joanne S; Friesen, Melissa C; Stewart, Patricia A; Donguk, Park; Johnson, Alison; Schwenn, Molly; Karagas, Margaret R; Armenti, Karla; Waddell, Richard; Verrill, Castine; Ward, Mary H; Freeman, Laura E Beane; Moore, Lee E; Koutros, Stella; Baris, Dalsu; Silverman, Debra T

    2014-10-01

    Metalworking has been associated with an excess risk of bladder cancer in over 20 studies. Metalworking fluids (MWFs) are suspected as the responsible exposure, but epidemiological data are limited. We investigated this association among men in the New England Bladder Cancer Study using state-of-the-art, quantitative exposure assessment methods. Cases (n=895) and population controls (n=1031) provided occupational histories during personal interviews. For selected jobs, exposure-oriented modules were administered to collect information on use of three MWF types: (1) straight (mineral oil, additives), (2) soluble (mineral oil, water, additives) and (3) synthetic (water, organics, additives) or semisynthetic (hybrid of soluble and synthetic). We computed ORs and 95% CIs relating bladder cancer risk to a variety of exposure metrics, adjusting for smoking and other factors. Non-metalworkers who had held jobs with possible exposure to mineral oil were analysed separately. Bladder cancer risk was elevated among men who reported using straight MWFs (OR=1.7, 95% CI 1.1 to 2.8); risk increased monotonically with increasing cumulative exposure (p=0.041). Use of soluble MWFs was associated with a 50% increased risk (95% CI 0.96 to 2.5). ORs were non-significantly elevated for synthetic/semisynthetic MWFs based on a small number of exposed men. Non-metalworkers holding jobs with possible exposure to mineral oil had a 40% increased risk (95% CI 1.1 to 1.8). Exposure to straight MWFs was associated with a significantly increased bladder cancer risk, as was employment in non-metalworking jobs with possible exposure to mineral oil. These findings strengthen prior evidence for mineral oil as a bladder carcinogen. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

  19. A behavioral strategy to minimize air pollution exposure in pregnant women: a randomized controlled trial.

    Science.gov (United States)

    Araban, Marzieh; Tavafian, Sedigheh Sadat; Zarandi, Saeed Motesaddi; Hidarnia, Ali Reza; Burri, Andrea; Montazeri, Ali

    2017-04-04

    Pregnant women and their fetus belong to a sensitive group in response to air pollution hazards. The aim of this study was to evaluate the effectiveness of a theory-based educational program to change pollution exposure behavior in pregnant women. In this randomized controlled trial, pregnant women attending a prenatal clinic in Tehran, Iran were selected and randomized into the experimental and control groups. The inclusion criteria were age between 18 and 35 years, having a history of pregnancies without adverse outcomes and not suffering from chronic diseases. Data collected at baseline and 2-month follow-up. At baseline face-to-face interviews were conducted using a valid and reliable questionnaire including items on demographic characteristics, stages of change, self-efficacy, decisional balance and practice regarding air pollution preventive behaviors. The intervention composed of three parts: motivational interviewing, a booklet and daily small message service (SMS). The control group received no intervention except receiving usual care. Follow-up data were collected after the intervention. Data were analyzed performing t-test, Mann-Whitney U test, and chi-squared. In all the data for 104 pregnant women (53 in the intervention and 51 in the control group) were analyzed. The mean age of participants was 27.2 (SD = 4.11) years and it was 22.89 (SD = 8.75) weeks for gestational age. At baseline there were no significant statistical differences between intervention and control groups on the study measures while we found significant group differences in terms of stages of change, self-efficacy, perceived benefits and practice regarding air pollution preventive behaviors at follow-up assessment (P pollution preventive behaviors among pregnant women. This study provided a framework to modify some psychosocial determinants of air pollution preventive behavior other than knowledge using constructs of Transtheoretical model of behavior change, additionally

  20. Assessing the risk to green sturgeon from application of imidacloprid to control burrowing shrimp in Willapa Bay, Washington--Part II: controlled exposure studies.

    Science.gov (United States)

    Frew, John A; Grue, Christian E

    2015-11-01

    The activities of 2 species of burrowing shrimp have a negative impact on the growth and survival of oysters reared on intertidal mudflats in Willapa Bay and Grays Harbor, Washington (USA). To maintain viable harvests, oyster growers proposed the application of the neonicotinoid insecticide imidacloprid onto harvested beds for the control of burrowing shrimp. In test applications, water column concentrations of imidacloprid were relatively low and dissipated rapidly. The foraging activities of the green sturgeon (listed in the US Endangered Species Act) could result in exposure to higher, more sustained imidacloprid concentrations within sediment porewater and from the consumption of contaminated shrimp. Controlled experiments were conducted using surrogate white sturgeon to determine acute and chronic effect concentrations, to examine overt effects at more environmentally realistic concentrations and durations of exposure, and to assess chemical depuration. The 96-h median lethal concentration was 124 mg L(-1) , and the predicted 35-d no-observed-adverse-effect concentration was 0.7 mg L(-1) . No overt effects were observed following environmentally relevant exposures. Imidacloprid half-life in plasma was greater than 32 h. Measured concentrations of imidacloprid in porewater were significantly lower than the derived acute and chronic effect concentrations for white sturgeon. Exposure risk quotients were calculated using the effect concentrations and estimated environmental exposure. The resulting values were considerably below the level of concern for direct effects from either acute or chronic exposure to an endangered species. © 2015 SETAC.

  1. Assessment of gamma radiation exposure inside a newly constructed building and a proposed regulatory guideline for exposure control from natural radioactivity in future buildings

    International Nuclear Information System (INIS)

    Shukla, V.K.; Sadasivan, S.; Sundaram, V.K.; Nambi, K.S.V.

    1995-01-01

    Naturally occurring radionuclides in building materials are one of the sources of radiation exposure of the population. The various materials used for constructing a new building were assessed for 40 K, 232 Th and 238 U radioactivity and the external gamma dose rate inside the building was predicted by using the computer code QAD-CGGP. The external dose rate was also measured by a scintillation gamma monitor after the construction of the building. In the building studied, the floor and the ceilings are seen to contribute about 35% each of the total radiation dose inside the building from the natural radioactivity present in the construction materials and the underlying soil; the walls contributed about 15%. A sensitivity analysis assuming extreme conditions of radioactivity concentrations as are normally observed in the Indian context, indicates the possibility of indoor gamma radiation fields varying by two orders of magnitude. The possible control methodologies and recommendations are also discussed for keeping the population exposure as low as reasonable achievable. It is evaluated that radioactivity limits of 370 Bq.kg -1 of radium equivalent and 85 Bq.kg -1 of 226 Ra when applied concurrently, might limit the indoor exposure to reasonably accepted low levels of health risks. (author)

  2. Preferential recognition of auto-antibodies against 4-hydroxynonenal modified DNA in the cancer patients.

    Science.gov (United States)

    Faisal, Mohammad; Shahab, Uzma; Alatar, Abdulrahman A; Ahmad, Saheem

    2017-11-01

    The structural perturbations in DNA molecule may be caused by a break in a strand, a missing base from the backbone, or a chemically changed base. These alterations in DNA that occurs naturally can result from metabolic or hydrolytic processes. DNA damage plays a major role in the mutagenesis, carcinogenesis, aging and various other patho-physiological conditions. DNA damage can be induced through hydrolysis, exposure to reactive oxygen species (ROS) and other reactive carbonyl metabolites including 4-hydroxynonenal (HNE). 4-HNE is an important lipid peroxidation product which has been implicated in the mutagenesis and carcinogenesis processes. The present study examines to probe the presence of auto-antibodies against 4-hydroxynonenal damaged DNA (HNE-DNA) in various cancer subjects. In this study, the purified calf thymus DNA was damaged by the action of 4-HNE. The DNA was incubated with 4-HNE for 24 h at 37°C temperature. The binding characteristics of cancer auto-antibodies were assessed by direct binding and competitive inhibition ELISA. DNA modifications produced hyperchromicity in UV spectrum and decreased fluorescence intensity. Cancer sera exhibited enhanced binding with the 4-HNE modified calf thymus DNA as compared to its native conformer. The 4-HNE modified DNA presents unique epitopes which may be one of the factors for the auto-antibody induction in cancer patients. The HNE modified DNA presents unique epitopes which may be one of the factors for the autoantibody induction in cancer patients. © 2017 Wiley Periodicals, Inc.

  3. Pleural mesothelioma and occupational and non-occupational asbestos exposure: a case-control study with quantitative risk assessment.

    Science.gov (United States)

    Ferrante, Daniela; Mirabelli, Dario; Tunesi, Sara; Terracini, Benedetto; Magnani, Corrado

    2016-03-01

    Casale Monferrato (north west Italy) is an area with an exceptionally high incidence of mesothelioma caused by asbestos contamination at work and in the general environment from the asbestos-cement Eternit plant that was operational until 1986. The purpose of this study was to quantify the association between pleural malignant mesothelioma (PMM) and asbestos cumulative exposure using individual assessment of environmental and domestic exposure, as well as of occupational exposure. This population-based case-control study included cases of PMM diagnosed between January 2001 and June 2006 among residents in the Casale Monferrato Local Health Authority. Population controls were randomly sampled, matched by age and sex to cases. Cumulative exposure was estimated to account for the lifelong exposure history. Analyses were conducted using unconditional logistic regression models adjusting for gender, age at diagnosis and type of interview (direct or proxy respondents). 200 PMM cases of 223 eligible cases (89.7%) and 348 (63%) of 552 eligible controls accepted to be interviewed. ORs increased with cumulative exposure index (p<0.0001) from 4.4 (CI 95% 1.7 to 11.3) (<1 f/mL-years) to 62.1 (CI 95% 22.2 to 173.2) (≥10 f/mL-years). Among subjects never occupationally exposed, corresponding ORs were 3.8 (CI 95% 1.3 to 11.1) and 23.3 (CI 95% 2.9 to 186.9) (reference: background level of asbestos exposure). ORs of about 2, statistically significant, were observed for domestic exposure and for living in houses near buildings with large asbestos cement parts. Risk of PMM increased with cumulative asbestos exposure and also in analyses limited to subjects non-occupationally exposed. Our results also provide indication of risk associated with common sources of environmental exposure and are highly relevant for the evaluation of residual risk after the cessation of asbestos industrial use. Published by the BMJ Publishing Group Limited. For permission to use (where not already

  4. Doses under automatic exposure control (AEC) for direct digital radiographic (DDR) X-ray systems.

    Science.gov (United States)

    Bowden, Louise; Faulkner, Ronan; Clancy, Conor; Gallagher, Aoife; Devine, Mark; Gorman, Dermot; O'Reilly, Geraldine; Dowling, Anita

    2011-09-01

    Current guidelines quote tolerances for automatic exposure control (AEC) device performance for X-ray systems as 'Baseline ± X %'. However, in the situation where a baseline figure has not yet been achieved, as in the case of commissioning assessments, this tolerance is not relevant. The purpose of this work is to provide mean doses for direct digital radiography (DDR) X-ray system, operating in AEC, against which comparisons can be made. Dose measurements have been recorded under AEC operation on 29 DDR detectors from three different manufacturers. Two different testing protocols were examined: (1) water equivalent phantoms in front of the DDR detector and (2) aluminium block at the tube head. The average patient exit dose, using the aluminium block was 4.6 μGy with the antiscatter grid in place and 4.0 μGy with the grid removed. Using the water phantoms, the average dose was measured at 17.1 μGy with the antiscatter grid in place and 5.4 μGy with grid removed. Based on these results, it is clear that different testing configurations significantly impact on the measured dose.

  5. THE AUTOMATED SYSTEM OF RADIATION EXPOSURE CONTROL (ASCRE FOR ROSPOTREBNADZOR: CREATION HISTORY, APPLICABILITY AND DEVELOPMENT

    Directory of Open Access Journals (Sweden)

    L. V. Repin

    2014-01-01

    Full Text Available The article describes the automated system of radiation exposure control (ASCRE for Rospotrebnadzor developed  in  the  framework  of  the  Federal  target  program  "Nuclear  and  Radiation  Safety  in  2008  and  for  the period till 2015". The history of the development of this system is given. It is shown the diagram of the functioning of ASCRE, description of the individual blocks of diagram is given. It is shown that the grpouping of the data from various Federal banks in the single automated information-analytical system on the general address basis with the wide possibilities of analytical tools application will greatly expand the range of the issues for the assessment of radiation impact on the population than in the existing systems. The use of automation resources will reduce the time for obtaining the necessary information and, ultimately, will increase the effectiveness of the decision making in the field of radiation protection.

  6. Aortic baroreflex control of heart rate after 15 days of simulated microgravity exposure

    Science.gov (United States)

    Crandall, Craig G.; Engelke, Keith A.; Convertino, Victor A.; Raven, Peter B.

    1994-01-01

    To determine the effects of simulated microgravity on aortic baroreflex control of heart rate, we exposed seven male subjects to 15 days of bed rest in the 6 deg head-down position. The sensitivity of the aortic-cardiac baroreflex was determined during a steady-state phenylephrine-induced increase in mean arterial pressure combined with lower body negative pressure to counteract central venous pressure increases and neck pressure to offset the increased carotid sinus transmural pressure. The aortic-cardiac baroreflex gain was assessed by determining the ratio of the change in heart rate to the change in mean arterial pressure between baseline conditions and aortic baroreceptor-isolated conditions (i.e., phenylephrine + lower body negative pressure + neck pressure stage). Fifteen days of head-down tilt increased the gain of the aortic-cardiac baroreflex. Reductions in blood volume and/or maximal aerobic capacity may represent the underlying mechanism(s) responsible for increased aortic baroreflex responsiveness after exposure to a ground-based analogue of microgravity.

  7. Self-reported exposure to pesticides in residential settings and risk of breast cancer: a case-control study

    Directory of Open Access Journals (Sweden)

    Graber Nora J

    2010-06-01

    Full Text Available Abstract Background Pesticides are widely used in households to control insects and weeds. Several studies, over the past decades, have examined the possible relationship of serum concentration of organochlorine pesticides and the development of breast cancer. However, little data exists regarding an association between self-reported, residential exposure to pesticides and breast cancer risk. We, therefore, present a case-control study examining self-reported exposure to household pesticides with regard to associated risk of breast cancer. Methods This study was conducted in the area in and around New York City, NY and included 1205 patients (447 cases and 758 controls. Cases were defined as women with newly diagnosed breast cancer or carcinoma in-situ, while controls included women with benign breast diseases or those undergoing non-breast related surgery. All patients were asked a series of questions to determine their pesticide exposure, including the type of pesticide, location of exposure (inside vs. outside the home, who applied the pesticide (self vs. a professional and duration of pesticide use. Logistic regression models were used to estimate unadjusted and adjusted odds ratios (OR and corresponding 95% confidence intervals (CI. Results The most common pests encountered in participants' homes were ants, carpenter ants, and cockroaches. The calculated adjusted odds ratios for both self and professionally applied pesticides, specifically against the above mentioned insects, with regard to breast cancer risk were 1.25 (95% CI: 0.79-1.98 and 1.06 (95% CI: 0.65-1.73, respectively. Similarly, odds ratios and confidence intervals were calculated for other types of pesticides. Conclusions Overall, the results of our study did not show an association between self-reported exposure to pesticides and breast cancer risk. Future studies, utilizing a larger sample size and more specific detail on time frame of pesticide exposure, are needed to

  8. Colistin exposure as a risk factor for infections caused by inherently colistin resistant Enterobacteriaceae-a case-control study.

    Science.gov (United States)

    Drozdinsky, G; Ben-Zvi, H; Kushnir, S; Leibovici, L; Yahav, D

    2017-12-05

    Epidemiological studies have suggested an association between increased colistin use and selection for inherently colistin-resistant Enterobacteriaceae (ICRE). We aimed to evaluate whether colistin exposure is a risk factor for ICRE infection. A matched 1:1 case-control study including patients recently hospitalized for ≥14 days with ICRE infection as cases matched with similar patients with a clinical isolate of a colistin-susceptible Enterobacteriaceae as controls was performed. Univariate analysis using McNemar test and multivariate analysis were conducted to explore risk factors for ICRE isolation, including colistin exposure 90 days before the positive culture. We included 446 patients, 223 cases and 223 controls matched for gender, age, department, year, source of culture and duration of hospitalization before positive culture. Colistin exposure was significantly associated with ICRE isolation in both univariate (14/223, 6.3% of cases versus 4/223, 1.8% of controls, p 0.031) and multivariate analyses (odds ratio 4.415, 95% CI 1.078-18.082). Curtailed functional capacity was a significant risk factor for ICRE as well. Exposure to other broad-spectrum antibiotics was associated with isolation of a colistin-susceptible pathogen. Exposure to colistin is associated with an increased risk of isolating an inherently colistin-resistant Enterobacteriaceae in patients with prolonged hospitalization. This should be taken into account while considering empirical therapy for such patients. Use of colistin should be judicious. The correlation between duration and magnitude of exposure and ICRE infection should be investigated in further studies. Copyright © 2017 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.

  9. Auto-tuning systems for J-PARC LINAC RF cavities

    International Nuclear Information System (INIS)

    Fang, Z.; Kobayashi, T.; Fukui, Y.; Futatsukawa, K.; Michizono, S.; Yamaguchi, S.; Anami, S.; Suzuki, H.; Sato, F.; Shinozaki, S.; Chishiro, E.

    2014-01-01

    The 400-MeV proton linear accelerator (LINAC) at the Japan Proton Accelerator Research Complex (J-PARC) consists of 324-MHz low-β and 972-MHz high-β accelerator sections. From October 2006 to May 2013, only the 324-MHz low-β accelerator section was in operation. From the summer of 2013 the J-PARC LINAC was upgraded by installing the 972-MHz high-β accelerator section, and the proton beam was successfully accelerated to 400 MeV in January 2014. Auto-tuning systems for the J-PARC LINAC RF cavities have been successfully developed. A first generation design, an auto-tuning system using a mechanical tuner controller, was developed and operated for the first 3 years. Then the second-generation auto-tuning system was developed using a new approach to the RF cavity warm-up process, and this was applied to the accelerator operation for the subsequent 4 years. During the RF cavity warm-up process in this system, the mechanical tuner is constantly fixed and the input RF frequency is automatically tuned to the cavity resonance frequency using the FPGA (Field-Programmable Gate Array) of the digital feedback RF control system. After the input power level reaches the required value, input RF frequency tuning is stopped and it is switched to the operation frequency. Then, the mechanical tuner control begins operation. This second-generation auto-tuning system was extremely effective for the 324-MHz cavity operation. However, if we apply this approach to the 972-MHz RF cavities, an interlock due to the RF cavity reflection amplitude occasionally occurs at the end of the warm-up process. In order to solve this problem a third generation novel auto-tuning system was successfully developed in December 2013 and applied to the operation of the J-PARC LINAC, including the 972-MHz ACS RF cavities. During the warm-up process both the mechanical tuner controller and the input RF frequency tuning are in operation, and good matching between the input RF frequency and the RF cavity is

  10. Analysis on the Workspace of Six-degrees-of-freedom Industrial Robot Based on AutoCAD

    Directory of Open Access Journals (Sweden)

    Li Jin-quan

    2017-01-01

    Full Text Available This research discusses the workspace of the industrial robot with six degrees of freedom(6-DOF based on AutoCAD platform. Based on the analysis of the overall configuration of the robot, this research establishes the kinematic mathematical model of the industrial robot by using DH parameters, and then solves the workspace of the robot consequently. In the AutoCAD, Auto Lisp language program is adopted to simulate the two-dimensional(2D and three-dimensional(3D space of the robot. Software user interface is written by using the dialog box control language of Visual LISP. At last, the research analyzes the trend of the shape and direction of the workspace when the length and angle range of the robot are changed. This research lays the foundation for the design, control and planning of industrial robots.

  11. Exposure to Outdoor Air Pollution and Chronic Bronchitis in Adults: A Case-Control Study

    Directory of Open Access Journals (Sweden)

    P Salameh

    2012-08-01

    Full Text Available Background: Although Lebanon is a highly polluted country, so far no study has specifically been designed to assess the association between outdoor air pollution and chronic bronchitis in this country. Objective: To assess the association between exposure to outdoor air pollution and chronic bronchitis in Lebanon. Methods: A pilot case-control study was conducted in two tertiary care hospitals. Cases consisted of patients diagnosed with chronic bronchitis by a pulmonologist and those epidemiologically confirmed. Controls included individuals free of any respiratory signs or symptoms. After obtaining informed consent, a standardized questionnaire was administered. Results: Bivariate, stratified (over smoking status and gender and multivariate analyses revealed that passive smoking at home (ORa: 2.56, 95% CI: 1.73–3.80 and at work (ORa: 1.89, 95% CI: 1.13–3.17; older age (ORa: 1.75, 95% CI: 1.55–2.39; lower education (ORa: 1.44, 95% CI: 1.21–1.72; living close to a busy road (ORa: 1.95, 95% CI: 1.31– 2.89 and to a local power plant (ORa: 1.62, 95% CI: 1.07–2.45; and heating home by hot air conditioning (ORa: 1.85, 95% CI: 1.00–3.43 were moderately associated with chronic bronchitis; an inverse association was found with heating home electrically (ORa: 0.58, 95% CI: 0.39–0.85. A positive dose-effect relationship was observed in those living close to a busy road and to a local diesel exhaust source. Conclusion: Chronic bronchitis is associated with outdoor air pollution.

  12. Host outdoor exposure variability affects the transmission and spread of Zika virus: Insights for epidemic control.

    Directory of Open Access Journals (Sweden)

    Marco Ajelli

    2017-09-01

    Full Text Available Zika virus transmission dynamics in urban environments follow a complex spatiotemporal pattern that appears unpredictable and barely related to high mosquito density areas. In this context, human activity patterns likely have a major role in Zika transmission dynamics. This paper examines the effect of host variability in the amount of time spent outdoors on Zika epidemiology in an urban environment.First, we performed a survey on time spent outdoors by residents of Miami-Dade County, Florida. Second, we analyzed both the survey and previously published national data on outdoors time in the U.S. to provide estimates of the distribution of the time spent outdoors. Third, we performed a computational modeling evaluation of Zika transmission dynamics, based on the time spent outdoors by each person. Our analysis reveals a strong heterogeneity of the host population in terms of time spent outdoors-data are well captured by skewed gamma distributions. Our model-based evaluation shows that in a heterogeneous population, Zika would cause a lower number of infections than in a more homogenous host population (up to 4-fold differences, but, at the same time, the epidemic would spread much faster. We estimated that in highly heterogeneous host populations the timing of the implementation of vector control measures is the major factor for limiting the number of Zika infections.Our findings highlight the need of considering host variability in exposure time for managing mosquito-borne infections and call for the revision of the triggers for vector control strategies, which should integrate mosquito density data and human outdoor activity patterns in specific areas.

  13. A case-control study of hormonal exposures as etiologic factors for ALS in women : Euro-MOTOR

    NARCIS (Netherlands)

    Rooney, James P K; Visser, Anne E; D'Ovidio, Fabrizio; Vermeulen, Roel; Beghi, Ettore; Chio, Adriano; Veldink, Jan H.; Logroscino, Giancarlo; van den Berg, Leonard H.; Hardiman, Orla

    2017-01-01

    OBJECTIVE: To investigate the role of hormonal risk factors for amyotrophic lateral sclerosis (ALS) among women from 3 European countries. METHODS: ALS cases and matched controls were recruited over 4 years in Ireland, Italy, and the Netherlands. Hormonal exposures, including reproductive history,

  14. Effectiveness of personal protective equipment: Relevance of dermal and inhalation exposure to chlorpyrifos among pest control operators

    NARCIS (Netherlands)

    Jagt, K. van der; Tielemans, E.; Links, I.; Brouwer, D.; Hemmen, J. van

    2004-01-01

    This study assessed the effectiveness of a custom fit personal protective equipment (PPE) program aimed at reducing occupational exposure to pesticides. The intervention study was carried out on 15 pest control operators (PCOs) during mixing/loading and application of chlorpyrifos. Each worker was

  15. The role of locus of control and coping style in predicting longitudinal PTSD-trajectories after combat exposure

    DEFF Research Database (Denmark)

    Karstoft, K. I.; Armour, C.; Elklit, A.

    2015-01-01

    While longitudinal posttraumatic stress responses are known to be heterogeneous, little is known about predictors of those responses. We investigated if locus of control (LOC) and coping style are associated with long-term PTSD-trajectories after exposure to combat. Six hundred and seventy five I...

  16. Hurricane exposure and county fetal death rates, utilization of a county environmental quality index for confounding control.

    Science.gov (United States)

    The effects of natural disasters on public health are a rising concern, with increasing severity of disaster events. Many disaster studies utilize county-level analysis, however most do not control for county level environmental factors. Hurricane exposure during pregnancy could ...

  17. Multidimensional CAT Item Selection Methods for Domain Scores and Composite Scores with Item Exposure Control and Content Constraints

    Science.gov (United States)

    Yao, Lihua

    2014-01-01

    The intent of this research was to find an item selection procedure in the multidimensional computer adaptive testing (CAT) framework that yielded higher precision for both the domain and composite abilities, had a higher usage of the item pool, and controlled the exposure rate. Five multidimensional CAT item selection procedures (minimum angle;…

  18. Controlled exposure to diesel exhaust and traffic noise--Effects on oxidative stress and activation in mononuclear blood cells.

    Science.gov (United States)

    Hemmingsen, Jette Gjerke; Møller, Peter; Jantzen, Kim; Jönsson, Bo A G; Albin, Maria; Wierzbicka, Aneta; Gudmundsson, Anders; Loft, Steffen; Rissler, Jenny

    2015-05-01

    Particulate air pollution increases risk of cancer and cardiopulmonary disease, partly through oxidative stress. Traffic-related noise increases risk of cardiovascular disease and may cause oxidative stress. In this controlled random sequence study, 18 healthy subjects were exposed for 3h to diesel exhaust (DE) at 276 μg/m(3) from a passenger car or filtered air, with co-exposure to traffic noise at 48 or 75 dB(A). Gene expression markers of inflammation, (interleukin-8 and tumor necrosis factor), oxidative stress (heme oxygenase (decycling-1)) and DNA repair (8-oxoguanine DNA glycosylase (OGG1)) were unaltered in peripheral blood mononuclear cells (PBMCs). No significant differences in DNA damage levels, measured by the comet assay, were observed after DE exposure, whereas exposure to high noise levels was associated with significantly increased levels of hOGG1-sensitive sites in PBMCs. Urinary levels of 8-oxo-7,8-dihydro-2'-deoxyguanosine were unaltered. In auxiliary ex vivo experiments whole blood was incubated with particles from the exposure chamber for 3h without effects on DNA damage in PBMCs or intracellular reactive oxygen species production and expression of CD11b and CD62L adhesion molecules in leukocyte subtypes. 3-h exposure to DE caused no genotoxicity, oxidative stress or inflammation in PBMCs, whereas exposure to noise might cause oxidatively damaged DNA. Copyright © 2015 The Authors. Published by Elsevier B.V. All rights reserved.

  19. Utilização do AutoCAD 2004 para quantificação de pesquisas usando fotomicrografias eletrônicas AutoCAD 2004 to quantify electron-photomicrography

    Directory of Open Access Journals (Sweden)

    Carla Albertina Martins Almeida

    2007-08-01

    Full Text Available OBJETIVO: Avaliar o uso do programa AutoCAD 2004 para estudos quantitativos em microscopia eletrônica. MÉTODOS: A demonstração da utilização do AutoCAD 2004 foi feita em um modelo experimental de diabetes induzido em ratos, divididos em Grupo Controle (GC-10 animais e Grupo Diabético (GD - 10 animais, avaliados 1 mês depois da indução do diabetes. Os olhos foram removidos após o sacrifício dos animais e preparados para exame em microscópio eletrônico, tendo sido feitas fotografias dos vasos retinianos. Foi utilizado o programa AutoCAD2004 para avaliar a espessura da membrana basal dos vasos. Os resultados foram avaliados estatisticamente. RESULTADOS: Usando o método proposto foi possível realizar medidas quantitativas na membrana basal de vasos retinianos de ratos diabéticos. CONCLUSÃO: O AutoCAD 2004 se mostrou efetivo, seguro e de fácil utilização para a quantificação de fenômenos biológicos, sendo possível sugerir este meio para a realização de avaliações quantitativas em experimentos biológicos.OBJECTIVE: To determine if the AutoCAD 2004 program is available to be used in quantitative research on electron microscopy. METHODS: A demonstrative of the AutoCAD2004 was done in an experimental model of diabetes induced in rats. The animals were divided by lot in control group animals (GC-10 animals and diabetic group (GD - 10 animals, evaluated 1 month after the diabetes induction. The eyes were removed after sacrifice and prepared to electron microscopy. The retina was photographed and the AutoCAD2004 program was used to measure the basal membrane of retina vessels. The results were submitted to statistical analysis. RESULTS: The AutoCAD2004 was effective to obtain quantitative measures from the basal membrane of retina vessels and there were no difference between the studied groups. CONCLUSION: The AutoCAD2004 was effective, safe and easy to apply to quantify biological parameters, which allowed suggest it to

  20. Prenatal Cigarette Exposure and Infant Learning Stimulation as Predictors of Cognitive Control in Childhood

    Science.gov (United States)

    Mezzacappa, Enrico; Buckner, John C.; Earls, Felton

    2011-01-01

    Prenatal exposures to neurotoxins and postnatal parenting practices have been shown to independently predict variations in the cognitive development and emotional-behavioral well-being of infants and children. We examined the independent contributions of prenatal cigarette exposure and infant learning stimulation, as well as their…

  1. Adjunctive graded body image exposure for eating disorders: A randomized controlled initial trial in clinical practice.

    Science.gov (United States)

    Trottier, Kathryn; Carter, Jacqueline C; MacDonald, Danielle E; McFarlane, Traci; Olmsted, Marion P

    2015-07-01

    Graded body image exposure is a key component of CBT for eating disorders (EDs). However, despite being a highly anxiety-provoking intervention, its specific effectiveness is unknown. The aims of this initial study were to investigate the feasibility and preliminary effectiveness of individualized graded body image exposure to a range of feared/avoided body image-related situations in a sample of partially remitted ED patients. Forty-five female adult participants were randomly assigned to maintenance treatment as usual (MTAU) only or MTAU plus five sessions of graded body image exposure. The graded body image exposure intervention led to large improvements in body avoidance as measured by two different methods. In addition, there was evidence of a significant impact of body image exposure on the overvaluation of shape, but not weight, 5 months after treatment. Taken together, the current results provide evidence of the feasibility of adjunctive individualized graded body image exposure within a clinical treatment program and suggest that graded body image exposure reduces body avoidance behaviors in partially remitted ED patients. Our findings suggest that individualized graded body image exposure shows promise as an intervention targeting the overvaluation of shape in EDs. © 2014 Wiley Periodicals, Inc.

  2. Residential traffic noise exposure and vestibular schwannoma - a Danish case-control study

    DEFF Research Database (Denmark)

    Roswall, Nina; Stangerup, Sven-Eric; Cayé-Thomasen, Per

    2017-01-01

    BACKGROUND: Few risk factors for sporadic vestibular schwannoma (VS) are known. Several studies have proposed an increased risk with occupational noise exposure, whereas no studies have investigated residential traffic noise exposure as a risk factor. The present study investigated if residential...

  3. Cardiovascular disease and arsenic exposure in Inner Mongolia, China: a case control study

    Science.gov (United States)

    BACKGROUND: Millions of people are at risk from the adverse effects of arsenic exposure through drinking water. Increasingly, non-cancer effects such as cardiovascular disease have been associated with drinking water arsenic exposures. However, most studies have been conducted in...

  4. Efficacy of virtual reality exposure therapy for treatment of dental phobia: a randomized control trial

    NARCIS (Netherlands)

    Raghav, K.; Van Wijk, A.J.; Abdullah, F.; Islam, M.N.; Bernatchez, M.; De Jongh, A.

    2016-01-01

    Background: Virtual Reality Exposure Therapy (VRET) is found to be a promising and a viable alternative for in vivo exposure in the treatment of specific phobias. However, its usefulness for treating dental phobia is unexplored. The aims of the present study are to determine: (a) the efficacy of

  5. TU-CD-207-11: Patient-Driven Automatic Exposure Control for Dedicated Breast CT

    International Nuclear Information System (INIS)

    Hernandez, A; Gazi, P; Seibert, J; Boone, J

    2015-01-01

    Purpose: To implement automatic exposure control (AEC) in dedicated breast CT (bCT) on a patient-specific basis using only the pre-scan scout views. Methods: Using a large cohort (N=153) of bCT data sets, the breast effective diameter (D) and width in orthogonal planes (Wa,Wb) were calculated from the reconstructed bCT image and pre-scan scout views, respectively. D, Wa, and Wb were measured at the breast center-of-mass (COM), making use of the known geometry of our bCT system. These data were then fit to a second-order polynomial “D=F(Wa,Wb)” in a least squares sense in order to provide a functional form for determining the breast diameter. The coefficient of determination (R 2 ) and mean percent error between the measured breast diameter and fit breast diameter were used to evaluate the overall robustness of the polynomial fit. Lastly, previously-reported bCT technique factors derived from Monte Carlo simulations were used to determine the tube current required for each breast diameter in order to match two-view mammographic dose levels. Results: F(Wa,Wb) provided fitted breast diameters in agreement with the measured breast diameters resulting in R 2 values ranging from 0.908 to 0.929 and mean percent errors ranging from 3.2% to 3.7%. For all 153 bCT data sets used in this study, the fitted breast diameters ranged from 7.9 cm to 15.7 cm corresponding to tube current values ranging from 0.6 mA to 4.9 mA in order to deliver the same dose as two-view mammography in a 50% glandular breast with a 80 kV x-ray beam and 16.6 second scan time. Conclusion: The present work provides a robust framework for AEC in dedicated bCT using only the width measurements derived from the two orthogonal pre-scan scout views. Future work will investigate how these automatically chosen exposure levels affect the quality of the reconstructed image

  6. High density growth of T7 expression strains with auto-induction option

    Energy Technology Data Exchange (ETDEWEB)

    Studier, F. William (Stony Brook, NY)

    2010-07-20

    A bacterial growth medium for promoting auto-induction of transcription of cloned DNA in cultures of bacterial cells grown batchwise is disclosed. The transcription is under the control of a lac repressor. Also disclosed is a bacterial growth medium for improving the production of a selenomethionine-containing protein or polypeptide in a bacterial cell, the protein or polypeptide being produced by recombinant DNA techniques from a lac or T7lac promoter, the bacterial cell encoding a vitamin B12-dependent homocysteine methylase. Finally, disclosed is a bacterial growth medium for suppressing auto-induction of expression in cultures of bacterial cells grown batchwise, said transcription being under the control of lac repressor.

  7. Residential radon exposure, diet and lung cancer: a case-control study in a Mediterranean region.

    Science.gov (United States)

    Bochicchio, Francesco; Forastiere, Francesco; Farchi, Sara; Quarto, Maria; Axelson, Olav

    2005-05-10

    We performed a case-control study in Lazio, a region in central Italy characterized by high levels of indoor radon, Mediterranean climate and diet. Cases (384) and controls (404) aged 35-90 years were recruited in the hospital. Detailed information regarding smoking, diet and other risk factors were collected by direct interview. Residential history during the 30-year period ending 5 years before enrollment was ascertained. In each dwelling, radon detectors were placed in both the main bedroom and the living room for 2 consecutive 6-month periods. We computed odds ratios (ORs) and 95% confidence intervals (CIs) for time-weighted radon concentrations using both categorical and continuous unconditional logistic regression analysis and adjusting for smoking, diet and other variables. Radon measurements were available from 89% and 91% of the time period for cases and controls, respectively. The adjusted ORs were 1.30 (1.03-1.64), 1.48 (1.08-2.02), 1.49 (0.82-2.71) and 2.89 (0.45-18.6) for 50-99, 100-199, 200-399 and 400+ Bq/m(3), respectively, compared with 0-49 Bq/m(3) (OR = 1; 0.56-1.79). The excess odds ratio (EOR) per 100 Bq/m(3) was 0.14 (-0.11, 0.46) for all subjects, 0.24 (-0.09, 0.70) for subjects with complete radon measurements and 0.30 (-0.08, 0.82) for subjects who had lived in 1 or 2 dwellings. There was a tendency of higher risk estimates among subjects with low-medium consumption of dietary antioxidants (EOR = 0.32; -0.19, 1.16) and for adenocarcinoma, small cell and epidermoid cancers. This study indicates an association, although generally not statistically significant, between residential radon and lung cancer with both categorical and continuous analyses. Subjects with presumably lower uncertainty in the exposure assessment showed a higher risk. Dietary antioxidants may act as an effect modifier.

  8. A Nested Case-Control Study of Intrauterine Exposure to Persistent Organochlorine Pollutants and the Risk of Hypospadias

    Science.gov (United States)

    Rignell-Hydbom, Anna; Lindh, Christian H.; Dillner, Joakim; Jönsson, Bo A. G.; Rylander, Lars

    2012-01-01

    Background Environmental exposures to endocrine disrupting chemicals have been suggested as a risk factor for male genital abnormalities such as hypospadias. The aim of this case-control study was to investigate the association between fetal exposure to persistent organochlorine pollutants (POP) and the risk for hypospadias. Methodology/Principal Findings The Southern Sweden Maternity Cohort (SSMC) contains serum samples collected in early pregnancy among women in Southern Sweden. Linkages with the Medical Birth Register, the Malformation Register and the In-patient Register resulted in 390 SSMC mothers who had given birth to a boy with hypospadias in year 1986–2002 (mean 1995). For 237 of these (cases) sufficient amounts of serum for the chemical analyses were available. For each case, a control boy from the SSMC was randomly selected, matched for maternal age, birth year, parity and maternal smoking. PCB-153, p,p’-DDE and hexachlorbenzene (HCB) were used as biomarkers for POP exposure. The exposures were categorized into quartiles based on the distributions among the controls. There were no statistically significant trends between the a priori categorisation of the exposure variables and the risk for hypospadias. However, when the upper HCB quartile (>26 ng/ml) was compared to the other quartiles an odds ratio of 1.65 (95% CI 1.02 to 2.69) was obtained. p,p′-DDE levels above median (>1.0 ng/ml) compared to levels below 0.1 ng/ml gave an OR of 1.69 (95% CI 0.97 to 2.93). Conclusions The present study suggests that fetal exposure to HCB and p,p’-DDE may be a risk factor for hypospadias. PMID:23028613

  9. Exposure assessment and modeling of quartz in Swedish iron foundries for a nested case-control study on lung cancer.

    Science.gov (United States)

    Andersson, Lena; Bryngelsson, Ing-Liss; Ngo, Yen; Ohlson, Carl-Göran; Westberg, Håkan

    2012-01-01

    Exposure assessment of quartz in Swedish iron foundries was performed based on historical and current measurement data. To evaluate the exposure-response relationship between quartz exposure and lung cancer, we modeled quartz exposure from our database of measurements using determinants job title, time period, and company. Based on these modeled exposure data, we conducted a nested case-control evaluation. In our database, the overall individual, daily time-weighted average (TWA) quartz concentrations of current and historical data varied between 0.0018 and 4.9 mg/m(3), averaging 0.083 mg/m(3). Job titles with mean TWAs for the whole study period exceeding the European Union recommended occupational exposure limit of 0.05 mg/m(3) were fettlers (0.087 mg/m(3)), furnace and ladle repair (0.42 mg/m(3)), and maintenance (0.054 mg/m(3)) workers. The mixed model analysis demonstrated significant determinants on the job level for furnace and ladle repair (β = 4.06; 95% confidence interval [CI] 2.78-5.93). For all jobs, significantly higher exposure levels occurred only during the first time period, 1968-1979 (β = 2.08; 95% CI 1.75-2.47), and a decreasing but not significant trend was noted for the three following 10-year time periods up to 2006 (β = 1.0, 0.96 and 1, respectively). Two iron foundries had significantly higher quartz concentration levels than the others (β = 1.31; 95% CI 1.00-1.71 and β = 1.63; 95% CI 1.00-2.65, respectively). The individual cumulative quartz exposure measures were categorized in low, medium, and high exposure (0.5-0.05 mg/m(3) of quartz. To conclude, certain foundry workers are still exposed to high levels of quartz, but an increased risk of lung cancer caused by quartz exposure in these Swedish iron foundries could not be confirmed at our exposure levels.

  10. Assessment Method for the Accuracy of Auto-Parking System

    Directory of Open Access Journals (Sweden)

    Shidian Ma

    2014-08-01

    Full Text Available Considering the condition of small sample sizes, quantifies uncertainty from systematic measurement error, this paper presents an accuracy Comprehensive evaluation method for Auto-Parking System based on bootstrap method. Collecting parking precision data by 8 practical experiments and taking the full use of the various information of limited sample data, we resample from the original samples, and then generate groups of sample data which are identical distributed. Finally, using 90 percent confidence levels, we assess the accuracy of Auto-Parking system, the result prove that the accuracy comprehensive evaluation method for Auto-Parking System based on bootstrap is a convenient and effective method.

  11. Web Proxy Auto Discovery for the WLCG

    Science.gov (United States)

    Dykstra, D.; Blomer, J.; Blumenfeld, B.; De Salvo, A.; Dewhurst, A.; Verguilov, V.

    2017-10-01

    All four of the LHC experiments depend on web proxies (that is, squids) at each grid site to support software distribution by the CernVM FileSystem (CVMFS). CMS and ATLAS also use web proxies for conditions data distributed through the Frontier Distributed Database caching system. ATLAS & CMS each have their own methods for their grid jobs to find out which web proxies to use for Frontier at each site, and CVMFS has a third method. Those diverse methods limit usability and flexibility, particularly for opportunistic use cases, where an experiment’s jobs are run at sites that do not primarily support that experiment. This paper describes a new Worldwide LHC Computing Grid (WLCG) system for discovering the addresses of web proxies. The system is based on an internet standard called Web Proxy Auto Discovery (WPAD). WPAD is in turn based on another standard called Proxy Auto Configuration (PAC). Both the Frontier and CVMFS clients support this standard. The input into the WLCG system comes from squids registered in the ATLAS Grid Information System (AGIS) and CMS SITECONF files, cross-checked with squids registered by sites in the Grid Configuration Database (GOCDB) and the OSG Information Management (OIM) system, and combined with some exceptions manually configured by people from ATLAS and CMS who operate WLCG Squid monitoring. WPAD servers at CERN respond to http requests from grid nodes all over the world with a PAC file that lists available web proxies, based on IP addresses matched from a database that contains the IP address ranges registered to organizations. Large grid sites are encouraged to supply their own WPAD web servers for more flexibility, to avoid being affected by short term long distance network outages, and to offload the WLCG WPAD servers at CERN. The CERN WPAD servers additionally support requests from jobs running at non-grid sites (particularly for LHC@Home) which they direct to the nearest publicly accessible web proxy servers. The responses

  12. Narrative exposure therapy versus interpersonal psychotherapy. A pilot randomized controlled trial with Rwandan genocide orphans.

    Science.gov (United States)

    Schaal, Susanne; Elbert, Thomas; Neuner, Frank

    2009-01-01

    The aim of the present study was to evaluate the efficacy of treatment modules for trauma spectrum disorders in a sample of Rwandan genocide orphans. Twenty-six orphans (originally 27) who presented with posttraumatic stress disorder (PTSD) at first assessment continued to meet a PTSD DSM-IV diagnosis 6 months after their initial assessment. They were offered participation in a controlled treatment trial. A group adaptation of interpersonal psychotherapy (IPT, n = 14) was compared to individual narrative exposure therapy (NET, n = 12). The last NET session involved guided mourning. Each treatment program consisted of 4 weekly sessions. Main outcome measures were diagnostic status and symptoms of PTSD and depression assessed before treatment, at 3 months post-test and at 6 months follow-up using the Clinician-Administered PTSD Scale, Mini-International Neuropsychiatric Interview, and Hamilton Rating Scale. At post-test, there were no significant group differences between NET and IPT on any of the examined outcome measures. At 6-month follow-up, only 25% of NET, but 71% of IPT participants still fulfilled PTSD criteria. There was a significant time x treatment interaction in the severity of PTSD [Wilks' Lambda = 0.75, F(2,23) = 3.93; p < 0.05] and depression symptoms [Wilks' Lambda = 0.23, F(2,23) = 3.40; p = 0.05]. At follow-up, NET participants were significantly more improved than IPT participants with respect to both the severity of symptoms of PTSD and depression. Individual NET in combination with group-based mourning comprises an effective treatment for traumatized survivors who have to bear the loss of loved ones and have been suffering from symptoms of PTSD and depression. Copyright 2009 S. Karger AG, Basel.

  13. An investigation of automatic exposure control calibration for chest imaging with a computed radiography system

    International Nuclear Information System (INIS)

    Moore, C S; Wood, T J; Beavis, A W; Saunderson, J R; Avery, G; Balcam, S; Needler, L

    2014-01-01

    The purpose of this study was to examine the use of three physical image quality metrics in the calibration of an automatic exposure control (AEC) device for chest radiography with a computed radiography (CR) imaging system. The metrics assessed were signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR) and mean effective noise equivalent quanta (eNEQ m ), all measured using a uniform chest phantom. Subsequent calibration curves were derived to ensure each metric was held constant across the tube voltage range. Each curve was assessed for its clinical appropriateness by generating computer simulated chest images with correct detector air kermas for each tube voltage, and grading these against reference images which were reconstructed at detector air kermas correct for the constant detector dose indicator (DDI) curve currently programmed into the AEC device. All simulated chest images contained clinically realistic projected anatomy and anatomical noise and were scored by experienced image evaluators. Constant DDI and CNR curves do not appear to provide optimized performance across the diagnostic energy range. Conversely, constant eNEQ m  and SNR do appear to provide optimized performance, with the latter being the preferred calibration metric given as it is easier to measure in practice. Medical physicists may use the SNR image quality metric described here when setting up and optimizing AEC devices for chest radiography CR systems with a degree of confidence that resulting clinical image quality will be adequate for the required clinical task. However, this must be done with close cooperation of expert image evaluators, to ensure appropriate levels of detector air kerma. (paper)

  14. Computed tomography automatic exposure control techniques in 18F-FDG oncology PET-CT scanning.

    Science.gov (United States)

    Iball, Gareth R; Tout, Deborah

    2014-04-01

    Computed tomography (CT) automatic exposure control (AEC) systems are now used in all modern PET-CT scanners. A collaborative study was undertaken to compare AEC techniques of the three major PET-CT manufacturers for fluorine-18 fluorodeoxyglucose half-body oncology imaging. An audit of 70 patients was performed for half-body CT scans taken on a GE Discovery 690, Philips Gemini TF and Siemens Biograph mCT (all 64-slice CT). Patient demographic and dose information was recorded and image noise was calculated as the SD of Hounsfield units in the liver. A direct comparison of the AEC systems was made by scanning a Rando phantom on all three systems for a range of AEC settings. The variation in dose and image quality with patient weight was significantly different for all three systems, with the GE system showing the largest variation in dose with weight and Philips the least. Image noise varied with patient weight in Philips and Siemens systems but was constant for all weights in GE. The z-axis mA profiles from the Rando phantom demonstrate that these differences are caused by the nature of the tube current modulation techniques applied. The mA profiles varied considerably according to the AEC settings used. CT AEC techniques from the three manufacturers yield significantly different tube current modulation patterns and hence deliver different doses and levels of image quality across a range of patient weights. Users should be aware of how their system works and of steps that could be taken to optimize imaging protocols.

  15. Radiation exposure and central nervous system cancers: A case-control study among workers at two nuclear facilities

    International Nuclear Information System (INIS)

    Carpenter, A.V.; Flanders, W.D.; Frome, E.L.; Crawford-Brown, D.J.; Fry, S.A.

    1987-03-01

    A nested case-control study was conducted among workers employed between 1943 and 1977 at two nuclear facilities to investigate the possible association of primary malignant neoplasms of the central nervous system (CNS) with occupational exposure to ionizing radiation from external and internal sources. Eighty-nine white male and female workers, who according to the information on death certificates dies of primary CNS cancers, were identified as cases. Four matched controls were selected for each case. External radiation exposure data were available from film badge readings for individual workers, whereas radiation dose to lung from internally deposited radionuclides, mainly uranium, was estimated from area and personnel monitoring data and was used in analyses in lieu of the dose to the brain. Matched sets were included in the analyses only if information was available for the case and at least one of the corresponding controls. Thus, the analyses of external radiation included 27 cases and 90 matched controls, and 47 cases and 120 matched controls were analyzed for the effects of radiation from internally deposited uranium. No association was observed between deaths fron CNS cancers and occupational exposure to ionizing radiation from external or internal sources. However, due to the small number of monitored subjects and low doses, a weak association could not be ruled out. 43 refs., 1 fig., 15 tabs

  16. AutoDrug: fully automated macromolecular crystallography workflows for fragment-based drug discovery

    International Nuclear Information System (INIS)

    Tsai, Yingssu; McPhillips, Scott E.; González, Ana; McPhillips, Timothy M.; Zinn, Daniel; Cohen, Aina E.; Feese, Michael D.; Bushnell, David; Tiefenbrunn, Theresa; Stout, C. David; Ludaescher, Bertram; Hedman, Britt; Hodgson, Keith O.; Soltis, S. Michael

    2013-01-01

    New software has been developed for automating the experimental and data-processing stages of fragment-based drug discovery at a macromolecular crystallography beamline. A new workflow-automation framework orchestrates beamline-control and data-analysis software while organizing results from multiple samples. AutoDrug is software based upon the scientific workflow paradigm that integrates the Stanford Synchrotron Radiation Lightsource macromolecular crystallography beamlines and third-party processing software to automate the crystallography steps of the fragment-based drug-discovery process. AutoDrug screens a cassette of fragment-soaked crystals, selects crystals for data collection based on screening results and user-specified criteria and determines optimal data-collection strategies. It then collects and processes diffraction data, performs molecular replacement using provided models and detects electron density that is likely to arise from bound fragments. All processes are fully automated, i.e. are performed without user interaction or supervision. Samples can be screened in groups corresponding to particular proteins, crystal forms and/or soaking conditions. A single AutoDrug run is only limited by the capacity of the sample-storage dewar at the beamline: currently 288 samples. AutoDrug was developed in conjunction with RestFlow, a new scientific workflow-automation framework. RestFlow simplifies the design of AutoDrug by managing the flow of data and the organization of results and by orchestrating the execution of computational pipeline steps. It also simplifies the execution and interaction of third-party programs and the beamline-control system. Modeling AutoDrug as a scientific workflow enables multiple variants that meet the requirements of different user groups to be developed and supported. A workflow tailored to mimic the crystallography stages comprising the drug-discovery pipeline of CoCrystal Discovery Inc. has been deployed and successfully

  17. The demand-control model for job strain: a commentary on different ways to operationalize the exposure variable

    Directory of Open Access Journals (Sweden)

    Márcia Guimarães de Mello Alves

    2015-01-01

    Full Text Available Demand-control has been the most widely used model to study job strain in various countries. However, researchers have used the model differently, thus hindering the comparison of results. Such heterogeneity appears in both the study instrument used and in the definition of the main exposure variable - high strain. This cross-sectional study aimed to assess differences between various ways of operationalizing job strain through association with prevalent hypertension in a cohort of workers (Pro-Health Study. No difference in the association between high job strain and hypertension was found according to the different ways of operationalizing exposure, even though prevalence varied widely, according to the adopted form, from 19.6% for quadrants to 42% for subtraction tertile. The authors recommend further studies to define the cutoff for exposure variables using combined subjective and objective data.

  18. A randomized controlled study of power posing before public speaking exposure for social anxiety disorder: No evidence for augmentative effects.

    Science.gov (United States)

    Davis, Michelle L; Papini, Santiago; Rosenfield, David; Roelofs, Karin; Kolb, Sarah; Powers, Mark B; Smits, Jasper A J

    2017-12-01

    This manuscript details a randomized controlled study designed to test the efficacy of power posing (i.e., briefly holding postures associated with dominance and power) as an augmentative strategy for exposure therapy for social anxiety disorder (SAD). Seventy-three individuals diagnosed with SAD were assigned to one of three conditions: power posing, submissive posing, or rest (no posing) prior to participating in an exposure therapy session. Participants were assessed for between-group differences in pre- and post-manipulation salivary hormone levels, within-session subjective experiences of fear, and pre- and 1-week post-treatment SAD severity outcome measures. Though the intervention resulted in decreased SAD symptom severity one week later, analyses revealed no significant between-group differences on any tested variables. Accordingly, this study provides no evidence to suggest that power posing impacts hormone levels or exposure therapy outcomes. Copyright © 2017 Elsevier Ltd. All rights reserved.

  19. Assessment of Mechanical Damage to Odontocete Respiratory Tract Tissues After Controlled Exposure to Blasting

    National Research Council Canada - National Science Library

    Reidenberg, Joy

    2004-01-01

    The odontocete respiratory tract is adapted to withstand the gradual pressure changes associated with diving, yet nothing is known about how it responds to the sudden pressure changes of a blast exposure...

  20. Exposures and reactions to allergens among hairdressing apprentices and matched controls

    DEFF Research Database (Denmark)

    Bregnhøj, Anne; Søsted, Heidi; Menné, Torkil

    2011-01-01

    Early and extensive exposures to chemical substances such as are found in hair dyes, perfumes and nickel are known risk factors for allergic reactions. Hairdressing apprentices belong to a high-risk group, as they are exposed both occupationally and personally.......Early and extensive exposures to chemical substances such as are found in hair dyes, perfumes and nickel are known risk factors for allergic reactions. Hairdressing apprentices belong to a high-risk group, as they are exposed both occupationally and personally....

  1. Community Violence Exposure and Conduct Problems in Children and Adolescents with Conduct Disorder and Healthy Controls

    OpenAIRE

    Linda Kersten; Noortje Vriends; Martin Steppan; Nora M. Raschle; Martin Praetzlich; Helena Oldenhof; Robert Vermeiren; Lucres Jansen; Katharina Ackermann; Anka Bernhard; Anne Martinelli; Karen Gonzalez-Madruga; Ignazio Puzzo; Amy Wells; Jack C. Rogers

    2017-01-01

    Exposure to community violence through witnessing or being directly victimized has been associated with conduct problems in a range of studies. However, the relationship between community violence exposure (CVE) and conduct problems has never been studied separately in healthy individuals and individuals with conduct disorder (CD). Therefore, it is not clear whether the association between CVE and conduct problems is due to confounding factors, because those with high conduct problems also te...

  2. Development of regulatory criteria applicable to control of radiation exposures to the population from products containing radioactive material

    International Nuclear Information System (INIS)

    Rogers, L.R.; Western, F.

    1969-01-01

    Under the Atomic Energy Act of 1954 as amended, the Atomic Energy Commission is responsible for regulating the possession, use and transfer of byproduct, source and special nuclear materials in accordance with safety standards established by rule of the Commission to protect health and minimize danger to life and property. This paper describes some of the basic considerations in establishing safety criteria and regulations for authorizing the transfer and use of byproduct material (radioisotopes) in products for distribution to the general public. It discusses problems encountered in extending the broad guidance provided by the Federal Radiation Council (FRC) and by the International Commission of Radiological Protection and the National Council on Radiation Protection and Measurements (ICRP-NCRP), which is limited to total exposures of individuals and population groups to radiation from many sources, to appropriate controls on radioactivity in an individual consumer product which represents only one source of population exposures. The paper also discusses possible approaches to accomplishing the regulatory objectives of providing reasonable assurance that (1) the contribution of an individual product to total exposures that might be permitted under FRC and ICRP-NCRP guidance should not be disproportionate to the benefits to be derived, and (2) appropriate efforts are made to limit exposures to the population from individual classes of sources of exposure as far as practicable. Existing criteria and regulations pertaining to the control of radiation exposure to the population from products into which radioactive material is purposely introduced are described, and additional considerations which must be taken into account for the development of further criteria and regulations which are applicable to the possible wide-scale distribution of products containing radioactive material as a result of the Plowshare Programs are explored. (author)

  3. Media violence exposure and executive functioning in aggressive and control adolescents.

    Science.gov (United States)

    Kronenberger, William G; Mathews, Vincent P; Dunn, David W; Wang, Yang; Wood, Elisabeth A; Giauque, Ann L; Larsen, Joelle J; Rembusch, Mary E; Lowe, Mark J; Li, Tie-Qiang

    2005-06-01

    The relationship between media violence exposure and executive functioning was investigated in samples of adolescents with no psychiatric diagnosis or with a history of aggressive-disruptive behavior. Age-, gender-, and IQ-matched samples of adolescents who had no Diagnostic and Statistical Manual of Mental Disorders-fourth edition (DSM-IV; American Psychiatric Association, 1994) diagnosis (N = 27) and of adolescents who had DSM-IV Disruptive Behavior Disorder diagnoses (N = 27) completed measures of media violence exposure and tests of executive functioning. Moderate to strong relationships were found between higher amounts of media violence exposure and deficits in self-report, parent-report, and laboratory-based measures of executive functioning. A significant diagnosis by media violence exposure interaction effect was found for Conners' Continuous Performance Test scores, such that the media violence exposure-executive functioning relationship was stronger for adolescents who had Disruptive Behavior Disorder diagnoses. Results indicate that media violence exposure is related to poorer executive functioning, and this relationship may be stronger for adolescents who have a history of aggressive-disruptive behavior. Copyright 2004 Wiley Periodicals, Inc.

  4. Urgencia hipertensiva secundaria a enfermedad poliquística renal autosómica recesiva en lactante. Reporte de caso

    OpenAIRE

    Roxana Quisbert-Cruz; Flora Zárate-Mondragón

    2017-01-01

    La enfermedad poliquística renal asociada a la fibrosis hepática congénita es una enfermedad hereditaria; se encuentra dentro del espectro de las enfermedades fibroquísticas hepatorrenales. Su frecuencia estimada es de 1 en 20.000 nacidos vivos para la variedad de enfermedad poliquística renal autosómica recesiva y más rara para la variedad autosómica dominante. Se presenta un reporte de caso de un paciente cuyo padecimiento se inició con crisis hipertensiva de difícil control, debido a enfer...

  5. Information Processing in Auto-regulated Systems

    Directory of Open Access Journals (Sweden)

    Karl Javorszky

    2003-06-01

    Full Text Available Abstract: We present a model of information processing which is based on two concurrent ways of describing the world, where a description in one of the languages limits the possibilities for realisations in the other language. The two describing dimensions appear in our common sense as dichotomies of perspectives: subjective - objective; diversity - similarity; individual - collective. We abstract from the subjective connotations and treat the test theoretical case of an interval on which several concurrent categories can be introduced. We investigate multidimensional partitions as potential carriers of information and compare their efficiency to that of sequenced carriers. We regard the same assembly once as a contemporary collection, once as a longitudinal sequence and find promising inroads towards understanding information processing by auto-regulated systems. Information is understood to point out that what is the case from among alternatives, which could be the case. We have translated these ideas into logical operations on the set of natural numbers and have found two equivalence points on N where matches between sequential and commutative ways of presenting a state of the world can agree in a stable fashion: a flip-flop mechanism is envisioned. By following this new approach, a mathematical treatment of some poignant biomathematical problems is allowed. Also, the concepts presented in this treatise may well have relevance and applications within the information processing and the theory of language fields.

  6. The Auto-Gopher Deep Drill

    Science.gov (United States)

    Badescu, Mircea

    2014-01-01

    Subsurface penetration by coring, drilling or abrading is of great importance for a large number of space and earth applications. An Ultrasonic/Sonic Drill/Corer (USDC) has been in development at JPL's Nondestructive Evaluation and Advanced Actuators (NDEAA) lab as an adaptable tool for many of these applications. The USDC uses a novel drive mechanism to transform the high frequency ultrasonic or sonic vibrations of the tip of a horn into a lower frequency sonic hammering of a drill bit through an intermediate free-flying mass. The USDC device idea has been implemented at various scales from handheld drills to large diameter coring devices. A series of computer programs that model the function and performance of the USDC device were developed and were later integrated into an automated modeling package. The USDC has also evolved from a purely hammering drill to a rotary hammer drill as the design requirements increased form small diameter shallow drilling to large diameter deep coring. A synthesis of the Auto-Gopher development is presented in this paper.

  7. AutoCategorization for Customized Knowledge Portals, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — An AutoCategorizing Knowledge Management Engine ("AKM") will automate key capabilities for both human-human and human-agent collaboration tools in aerospace...

  8. Auto-immune haematological complications occurring during the ...

    African Journals Online (AJOL)

    Auto-immune haematological complications occurring during treatment for malignant Iymphoproliferative diseases are described in 5 patients. There appeared to be a temporal relationship between the development of these complications and the administration of chemotherapeutic drugs or extensive radiotherapy.

  9. A Moment in the Auto/biographical Enterprise | Jansen | Current ...

    African Journals Online (AJOL)

    Abstract. Judith Lütge Coullie, Stephan Meyer, Thengani H Ngwenya and Thomas Olver (eds). (2006) Selves in Question: Interviews on Southern African Auto/biography. Honolulu: University of Hawai'i Press.

  10. AutoCategorization for Customized Knowledge Portals Project

    Data.gov (United States)

    National Aeronautics and Space Administration — An AutoCategorizing Knowledge Management Engine ("AKM") will automate key capabilities for both human-human and human-agent collaboration tools in aerospace...

  11. Auto-regenerative thermoluminescence dating using zircon inclusions

    International Nuclear Information System (INIS)

    Templer, R.H.

    1993-01-01

    Fired ceramics containing zircon inclusions have been dated by allowing the zircons to regenerate their own thermoluminescence (TL) signal, hence auto-regenerative TL dating. The technique is conceptually straightforward. One first measures the TL accrued since the last heating of the material. The zircon grains are then stored for six months and the TL signal regenerated through self-irradiation is measured. Since the internal dose-rate for zircon is dominated by the internal component the age of the sample is simply given by the ratio of the natural to auto-regenerated signal times the laboratory storage period. The technique, however, requires the measurement of a very small auto-regenerated signal, which introduces a number of experimental and physical complications. The methods for overcoming these problems and successfully dating zircons by auto-regeneration are described. (Author)

  12. Linking mileage to auto accident risk and urban form.

    Science.gov (United States)

    2013-08-01

    Pricing auto insurance on a per-mile basis provides a beneficial, cost-based incentive to : reduce vehicle miles traveled compared with traditional rating plans that charge annual : premiums with little or no consideration of miles driven. : The rese...

  13. Auto industry : a framework for considering federal financial assistance.

    Science.gov (United States)

    2008-12-05

    The current economic downturn has brought significant financial stress to the auto manufacturing industry. Recent deteriorating financial, real estate, and labor markets have reduced consumer confidence and available credit, and automobile purchases ...

  14. Exposure assessment and engineering control strategies for airborne nanoparticles: an application to emissions from nanocomposite compounding processes

    International Nuclear Information System (INIS)

    Tsai, Candace S.-J.; White, David; Rodriguez, Henoc; Munoz, Christian E.; Huang, Cheng-Yu; Tsai, Chuen-Jinn; Barry, Carol; Ellenbecker, Michael J.

    2012-01-01

    In this study, nanoalumina and nanoclay particles were compounded separately with ethylene vinyl acetate (EVA) polymer to produce nanocomposites using a twin-screw extruder to investigate exposure and effective controls. Nanoparticle exposures from compounding processes were elevated under some circumstances and were affected by many factors including inadequate ventilation, surrounding air flow, feeder type, feeding method, and nanoparticle type. Engineering controls such as improved ventilation and enclosure of releasing sources were applied to the process equipment to evaluate the effectiveness of control. The nanoparticle loading device was modified by installing a ventilated enclosure surrounding the loading chamber. Exposures were studied using designed controls for comparison which include three scenarios: (1) no isolation; (2) enclosed sources; and (3) enclosed sources and improved ventilation. Particle number concentrations for diameters from 5 to 20,000 nm measured by the Fast Mobility Particle Sizer and aerodynamic particle sizer were studied. Aerosol particles were sampled on transmission electron microscope grids to characterize particle composition and morphology. Measurements and samples were taken at the near- and far-field areas relative to releasing sources. Airborne particle concentrations were reduced significantly when using the feeder enclosure, and the concentrations were below the baseline when two sources were enclosed, and the ventilation was improved when using either nanoalumina or nanoclay as fillers.

  15. Leisure time activities related to carcinogen exposure and lung cancer risk in never smokers. A case-control study

    International Nuclear Information System (INIS)

    Ruano-Ravina, Alberto; García-Lavandeira, José Antonio; Torres-Durán, María; Prini-Guadalupe, Luciana; Parente-Lamelas, Isaura; Leiro-Fernández, Virginia; Montero-Martínez, Carmen; González-Barcala, Francisco Javier; Golpe-Gómez, Antonio; Martínez, Cristina; Castro-Añón, Olalla; Mejuto-Martí, María José

    2014-01-01

    We aim to assess the relationship between leisure time activities related to exposure to carcinogenic substances and lung cancer risk in a hospital-based case-control study performed in never smokers. We included never smoking cases with anatomopathologically confirmed lung cancer and never smoking controls undergoing trivial surgery, at 8 Spanish hospitals. The study was conducted between January 2011 and June 2013. Participants were older than 30 and had no previous neoplasms. All were personally interviewed focusing on lifestyle, environmental tobacco smoke exposure, occupational history and leisure time activities (including duration of such activities). Results were analyzed through logistic regression and adjusted also by residential radon and education level. We included 513 never smokers, 191 cases and 322 controls. The OR for those performing the studied leisure time activities was 1.43 (95%CI 0.78–2.61). When we restricted the analysis to those performing do-it-yourself activities for more than 10 years the OR was 2.21 (95%CI 0.93–5.27). Environmental tobacco smoke exposure did not modify this association. The effect for the different lung cancer histological types was very close to significance for adenocarcinoma but only when these activities were performed for more than 10 years. We encourage health professionals to recommend protective measures for those individuals while performing these hobbies to reduce the risk of lung cancer. - Highlights: • Some leisure time activities are associated with the exposure to carcinogenic substances. • These activities are model-making, painting (artistic or not), furniture refinishing or wood working. • Few studies have assessed lung cancer risk due to these hobbies and none in never-smokers. • Leisure activities related to exposure to carcinogenic substances present higher lung cancer risk. • The risk is higher when these activities are performed for more than 10 years

  16. Leisure time activities related to carcinogen exposure and lung cancer risk in never smokers. A case-control study

    Energy Technology Data Exchange (ETDEWEB)

    Ruano-Ravina, Alberto, E-mail: alberto.ruano@usc.es [Department of Preventive Medicine and Public Health, University of Santiago de Compostela, Santiago de Compostela (Spain); CIBER de Epidemiología y Salud Pública CIBERESP, Barcelona (Spain); García-Lavandeira, José Antonio [Department of Preventive Medicine and Public Health, University of Santiago de Compostela, Santiago de Compostela (Spain); Department of Preventive Medicine, A Coruña University Hospital Complex, Coruña (Spain); Torres-Durán, María [Department of Preventive Medicine and Public Health, University of Santiago de Compostela, Santiago de Compostela (Spain); Service of Neumology, University Hospital Complex of Vigo, Vigo (Spain); Prini-Guadalupe, Luciana [Department of Preventive Medicine and Public Health, University of Santiago de Compostela, Santiago de Compostela (Spain); Parente-Lamelas, Isaura [Service of Neumology, Ourense Hospital Complex, Ourense (Spain); Leiro-Fernández, Virginia [Service of Neumology, University Hospital Complex of Vigo, Vigo (Spain); Montero-Martínez, Carmen [Service of Neumology, University Hospital Complex of A Coruña, Coruña (Spain); González-Barcala, Francisco Javier; Golpe-Gómez, Antonio [Service of Neumology, Santiago de Compostela University Clinic Hospital, Santiago de Compostela (Spain); Martínez, Cristina [National Institute of Silicosis, University Hospital of Asturias, Oviedo, Asturias (Spain); Castro-Añón, Olalla [Service of Neumology, Hospital Lucus Augusti, Lugo (Spain); Mejuto-Martí, María José [Service of Neumology, Hospital Arquitecto Marcide, Ferrol (Spain); and others

    2014-07-15

    We aim to assess the relationship between leisure time activities related to exposure to carcinogenic substances and lung cancer risk in a hospital-based case-control study performed in never smokers. We included never smoking cases with anatomopathologically confirmed lung cancer and never smoking controls undergoing trivial surgery, at 8 Spanish hospitals. The study was conducted between January 2011 and June 2013. Participants were older than 30 and had no previous neoplasms. All were personally interviewed focusing on lifestyle, environmental tobacco smoke exposure, occupational history and leisure time activities (including duration of such activities). Results were analyzed through logistic regression and adjusted also by residential radon and education level. We included 513 never smokers, 191 cases and 322 controls. The OR for those performing the studied leisure time activities was 1.43 (95%CI 0.78–2.61). When we restricted the analysis to those performing do-it-yourself activities for more than 10 years the OR was 2.21 (95%CI 0.93–5.27). Environmental tobacco smoke exposure did not modify this association. The effect for the different lung cancer histological types was very close to significance for adenocarcinoma but only when these activities were performed for more than 10 years. We encourage health professionals to recommend protective measures for those individuals while performing these hobbies to reduce the risk of lung cancer. - Highlights: • Some leisure time activities are associated with the exposure to carcinogenic substances. • These activities are model-making, painting (artistic or not), furniture refinishing or wood working. • Few studies have assessed lung cancer risk due to these hobbies and none in never-smokers. • Leisure activities related to exposure to carcinogenic substances present higher lung cancer risk. • The risk is higher when these activities are performed for more than 10 years.

  17. A population-based case-control study on statin exposure and risk of acute diverticular disease.

    Science.gov (United States)

    Sköldberg, Filip; Svensson, Tobias; Olén, Ola; Hjern, Fredrik; Schmidt, Peter T; Ljung, Rickard

    2016-01-01

    A reduced risk of perforated diverticular disease among individuals with current statin exposure has been reported. The aim of the present study was to investigate whether statins reduce the risk of acute diverticular disease. A nation-wide population-based case-control study was performed, including 13,127 cases hospitalised during 2006-2010 with a first-time diagnosis of colonic diverticular disease, and 128,442 control subjects (matched for sex, age, county of residence and calendar year). Emergency surgery, assumed to be a proxy for complicated diverticulitis, was performed on 906 of the cases during the index admission, with 8818 matched controls. Statin exposure was classified as "current" or "former" if a statin prescription was last dispensed ≤ 125 days or >125 days before index date, respectively. The association between statin exposure and acute diverticular disease was investigated by conditional logistic regression, including models adjusting for country of birth, educational level, marital status, comorbidities, nonsteroidal anti-inflammatory drug/steroid exposure and healthcare utilisation. A total of 1959 cases (14.9%) and 16,456 controls (12.8%) were current statin users (crude OR 1.23 [95% CI 1.17-1.30]; fully adjusted OR 1.00 [0.94-1.06]). One hundred and thirty-two of the cases subjected to surgery (14.6%), and 1441 of the corresponding controls (16.3%) were current statin users (crude OR 0.89 [95% CI 0.73-1.08]; fully adjusted OR 0.70 [0.55-0.89]). The results do not indicate that statins affect the development of symptomatic diverticular disease in general. However, current statin use was associated with a reduced risk of emergency surgery for diverticular disease.

  18. Implementación de una Carta de Control para Corridas Cortas en la Industria de AutopartesImplementation of a short Run chart in the Auto Parts Industry

    Directory of Open Access Journals (Sweden)

    Jesús Fidernan Barrera Cobos

    2016-01-01

    Full Text Available Contexto: La industria nacional tiene que adaptarse a las necesidades del mercado, lo que implica en algunos casos el cambio en la realización de sus procesos productivos. Uno de estos cambios tiene que ver con el tamaño de lote de producción, el cual ha pasado de un tamaño de miles de unidades a uno quizas, de algunos cientos. El seguimiento de estos procesos con métodos estadísticos, como las cartas de control, ha llevado al uso de las denominadas cartas de control para lotes pequeños. Método: En este artículo se presenta la propuesta de implementación de una carta de este tipo en un proceso de fabricación de una empresa del sector automotriz nacional. Inicialmente se plantea el estado actual del proceso, el cual se sigue con una carta de control  - R, usada por la empresa para el seguimiento de la producción; luego se hace mención a algunas de las cartas de control para lotes pequeños, que han sido planteadas por diversos autores. Resultados: Con base en la información del estado actual del proceso se realiza la elección de la carta para lotes pequeños más adecuada. Conclusiones: Dadas las características de no homogeneidad de la varianza, determinada mediante una prueba no paramétrica para las referencias analizadas, se decide que la carta a ser usada es la normalizada. De las tres propuestas de carta presentadas la decisión de cuál usar depende de la varianza del proceso al fabricar las distintas referencias.

  19. Auto-immune encefalitis in de psychiatrische praktijk

    OpenAIRE

    de Witte, L; Kromkamp, M; Schoenmaker, N; van Mierlo, H C; Martinez-Martínez, P; Palmen, S J M; Sommer, I E C

    2015-01-01

    BACKGROUND: Our knowledge about auto-immune limbic encephalitis is increasing rapidly and it is now evident that patients with this disease can present with psychiatric symptoms. AIM: To propose practical guidelines for the recognition and diagnosis of an underlying auto-immune limbic encephalitis in patients with acute psychiatric symptoms. METHOD: We studied recent reviews on the topic and had discussions with psychiatrists, a neurologist and a neuroimmunologist in order to reach consensus....

  20. 70 MeV injector auto tuning system handbook

    International Nuclear Information System (INIS)

    Ellis, J.E.; Munn, R.W.; Sandels, E.G.

    1976-06-01

    The handbook is in three sections: (1) description and location; (2) operating instructions; and (3) design notes on the tank and debuncher auto tuning systems for the 70 MeV injector. The purpose of the auto tuning system is to maintain the 'tune' of the four tanks and debuncher to within a few Hz, stabilizing against changes of temperature and other physical factors affecting the resonant frequency of the tanks. (U.K.)

  1. Effect of controlled adverse chamber environment exposure on tear functions in silicon hydrogel and hydrogel soft contact lens wearers.

    Science.gov (United States)

    Kojima, Takashi; Matsumoto, Yukihiro; Ibrahim, Osama M A; Wakamatsu, Tais Hitomi; Uchino, Miki; Fukagawa, Kazumi; Ogawa, Junko; Dogru, Murat; Negishi, Kazuno; Tsubota, Kazuo

    2011-11-11

    To prospectively evaluate the effect of controlled adverse chamber environment (CACE) exposure on tear function, including tear osmolarity, in subjects wearing narafilcon A versus those wearing etafilcon A soft contact lens (SCL). Thirty-one healthy subjects with no history of contact lens wear (13 women, 18 men; average age, 30.5 ± 6.5 years) were randomly divided into age- and sex-matched groups (15 subjects wearing narafilcon A SCL; 16 subjects wearing etafilcon A SCL) and entered a CACE for 20 minutes. All subjects underwent tear osmolarity, tear evaporation rate, strip meniscometry, tear film breakup time, fluorescein vital staining, and functional visual acuity measurement before and after exposure to the controlled adverse chamber. The mean blink rate increased with significant deteriorations in the mean symptom VAS scores, mean tear osmolarity, tear evaporation rate, strip meniscometry score, and tear stability with CACE exposure along with a decrease in visual maintenance ratio in functional visual acuity testing in etafilcon A wearers. The mean symptom VAS scores, mean tear evaporation rate, tear stability, blink rates, and visual maintenance ratios did not change significantly in narafilcon A wearers after CACE exposure. This study suggested marked tear instability, higher tear osmolarity, and increased tear evaporation with marked dry eye and visual symptomatology in nonadapted hydrogel SCL wearers, suggesting that silicone hydrogel SCLs may be suitable for persons who live and work in cool, low-humidity, and windy environments, as tested in this study.

  2. Auto-eficácia e sintomas depressivos em doentes com dor crônica

    OpenAIRE

    Salvetti,Marina de Góes; Pimenta,Cibele Andrucioli de Mattos; Lage,Lais Verderame; Oliveira Junior,José Oswaldo de; Rocha,Roberto de Oliveira

    2007-01-01

    CONTEXTO: Auto-eficácia é a crença na habilidade pessoal de desempenhar com sucesso tarefas ou de apresentar comportamentos para produzir um resultado desejável. É conceito-chave para o adequado controle de doenças crônicas e estudos sobre o tema são incipientes no Brasil. OBJETIVO: Avaliar a crença de auto-eficácia de pacientes com dor crônica e relacioná-la a variáveis sociodemográficas, de características da dor e à presença de sintomas depressivos. MÉTODOS: A amostra, de conveniência, foi...

  3. [Oral diseases in auto-immune polyendocrine syndrome type 1].

    Science.gov (United States)

    Proust-Lemoine, Emmanuelle; Guyot, Sylvie

    2017-09-01

    Auto-immune polyendocrine syndrome type 1 (APS1) also called Auto-immune Polyendocrinopathy Candidiasis Ectodermal Dystrophy (APECED) is a rare monogenic childhood-onset auto-immune disease. This autosomal recessive disorder is caused by mutations in the auto-immune regulator (AIRE) gene, and leads to autoimmunity targeting peripheral tissues. There is a wide variability in clinical phenotypes in patients with APSI, with auto-immune endocrine and non-endocrine disorders, and chronic mucocutaneous candidiasis. These patients suffer from oral diseases such as dental enamel hypoplasia and candidiasis. Both are frequently described, and in recent series, enamel hypoplasia and candidiasis are even the most frequent components of APS1 together with hypoparathyroidism. Both often occur during childhood (before 5 years old for canrdidiasis, and before 15 years old for enamel hypoplasia). Oral candidiasis is recurrent all life long, could become resistant to azole antifungal after years of treatment, and be carcinogenic, leading to severe oral squamous cell carcinoma. Oral components of APS1 should be diagnosed and rigorously treated. Dental enamel hypoplasia and/or recurrent oral candidiasis in association with auto-immune diseases in a young child should prompt APS1 diagnosis. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

  4. Environmental risk factors differ between rheumatoid arthritis with and without auto-antibodies against cyclic citrullinated peptides

    DEFF Research Database (Denmark)

    Pedersen, Line Merete Blak; Jacobsen, Søren; Klarlund, Mette

    2006-01-01

    The aim of this study was to evaluate new and previously hypothesised non-genetic risk factors for serologic subtypes of rheumatoid arthritis (RA) defined by the presence or absence of auto-antibodies to cyclic citrullinated peptides (CCP). In a national case-control study, we included 515 patients...

  5. Breast cancer risk in relation to occupations with exposure to carcinogens and endocrine disruptors: a Canadian case–control study

    Directory of Open Access Journals (Sweden)

    Brophy James T

    2012-11-01

    Full Text Available Abstract Background Endocrine disrupting chemicals and carcinogens, some of which may not yet have been classified as such, are present in many occupational environments and could increase breast cancer risk. Prior research has identified associations with breast cancer and work in agricultural and industrial settings. The purpose of this study was to further characterize possible links between breast cancer risk and occupation, particularly in farming and manufacturing, as well as to examine the impacts of early agricultural exposures, and exposure effects that are specific to the endocrine receptor status of tumours. Methods 1005 breast cancer cases referred by a regional cancer center and 1146 randomly-selected community controls provided detailed data including occupational and reproductive histories. All reported jobs were industry- and occupation-coded for the construction of cumulative exposure metrics representing likely exposure to carcinogens and endocrine disruptors. In a frequency-matched case–control design, exposure effects were estimated using conditional logistic regression. Results Across all sectors, women in jobs with potentially high exposures to carcinogens and endocrine disruptors had elevated breast cancer risk (OR = 1.42; 95% CI, 1.18-1.73, for 10 years exposure duration. Specific sectors with elevated risk included: agriculture (OR = 1.36; 95% CI, 1.01-1.82; bars-gambling (OR = 2.28; 95% CI, 0.94-5.53; automotive plastics manufacturing (OR = 2.68; 95% CI, 1.47-4.88, food canning (OR = 2.35; 95% CI, 1.00-5.53, and metalworking (OR = 1.73; 95% CI, 1.02-2.92. Estrogen receptor status of tumors with elevated risk differed by occupational grouping. Premenopausal breast cancer risk was highest for automotive plastics (OR = 4.76; 95% CI, 1.58-14.4 and food canning (OR = 5.70; 95% CI, 1.03-31.5. Conclusions These observations support hypotheses linking breast cancer risk and exposures likely to include carcinogens and

  6. Methods for CT automatic exposure control protocol translation between scanner platforms.

    Science.gov (United States)

    McKenney, Sarah E; Seibert, J Anthony; Lamba, Ramit; Boone, John M

    2014-03-01

    An imaging facility with a diverse fleet of CT scanners faces considerable challenges when propagating CT protocols with consistent image quality and patient dose across scanner makes and models. Although some protocol parameters can comfortably remain constant among scanners (eg, tube voltage, gantry rotation time), the automatic exposure control (AEC) parameter, which selects the overall mA level during tube current modulation, is difficult to match among scanners, especially from different CT manufacturers. Objective methods for converting tube current modulation protocols among CT scanners were developed. Three CT scanners were investigated, a GE LightSpeed 16 scanner, a GE VCT scanner, and a Siemens Definition AS+ scanner. Translation of the AEC parameters such as noise index and quality reference mAs across CT scanners was specifically investigated. A variable-diameter poly(methyl methacrylate) phantom was imaged on the 3 scanners using a range of AEC parameters for each scanner. The phantom consisted of 5 cylindrical sections with diameters of 13, 16, 20, 25, and 32 cm. The protocol translation scheme was based on matching either the volumetric CT dose index or image noise (in Hounsfield units) between two different CT scanners. A series of analytic fit functions, corresponding to different patient sizes (phantom diameters), were developed from the measured CT data. These functions relate the AEC metric of the reference scanner, the GE LightSpeed 16 in this case, to the AEC metric of a secondary scanner. When translating protocols between different models of CT scanners (from the GE LightSpeed 16 reference scanner to the GE VCT system), the translation functions were linear. However, a power-law function was necessary to convert the AEC functions of the GE LightSpeed 16 reference scanner to the Siemens Definition AS+ secondary scanner, because of differences in the AEC functionality designed by these two companies. Protocol translation on the basis of

  7. A case-control study of medium-term exposure to ambient nitrogen dioxide pollution and hospitalization for stroke.

    Science.gov (United States)

    Johnson, Julie Y M; Rowe, Brian H; Allen, Ryan W; Peters, Paul A; Villeneuve, Paul J

    2013-04-19

    There are several plausible mechanisms whereby either short or long term exposure to pollution can increase the risk of stroke. Over the last decade, several studies have reported associations between short-term (day-to-day) increases in ambient air pollution and stroke. The findings from a smaller number of studies that have looked at long-term exposure to air pollution and stroke have been mixed. Most of these epidemiological studies have assigned exposure to air pollution based on place of residence, but these assignments are typically based on relatively coarse spatial resolutions. To date, few studies have evaluated medium-term exposures (i.e, exposures over the past season or year). To address this research gap, we evaluated associations between highly spatially resolved estimates of ambient nitrogen dioxide (NO2), a marker of traffic pollution, and emergency department visits for stroke in Edmonton, Canada. This was a case-control study with cases defined as those who presented to an Edmonton area hospital emergency department between 2007 and 2009 with an acute ischemic stroke, hemorrhagic stroke, or transient ischemic attack. Controls were patients who presented to the same emergency departments for lacerations, sprains, or strains. A land-use regression model provided estimates of NO2 that were assigned to the place of residence. Logistic regression methods were used to estimate odds ratios for stroke in relation to an increase in the interquartile range of NO2 (5 ppb), adjusted for age, sex, meteorological variables, and neighborhood effects. The study included 4,696 stroke (cases) and 37,723 injury patients (controls). For all strokes combined, there was no association with NO2. Namely, the odds ratio associated with an interquartile increase in NO2 was 1.01 (95% confidence interval {CI}: 0.94-1.08). No associations were evident for any of the stroke subtypes examined. When combined with our earlier work in Edmonton, our findings suggest that day

  8. Study on optimized dispensing of F-18 FDG auto dispenser

    Energy Technology Data Exchange (ETDEWEB)

    Ji, Bong Geun; Lee, Sang Hun; Kim, Jong Eon; Kim, Won Tae; Kim, Tae Jeong [Dept. of Radiological Science, Kaya University, Kimhae (Korea, Republic of)

    2016-09-15

    This is a study on the optimized dispensing of the auto dispenser used for the purpose of reducing the exposure dose and accurate radiation dose of radioisotope with regard to the PET/CT practitioners. The research method was to find the optimized dispensing method through evaluating the results according to the syringe type, dispensing rate, and vial pressure and through the application of corrected values. As a result of this study, 9.38 mCi has been dispensed on average in the case of 5 ml syringe, and the reproducibility close to 10 mCi was shown at the dispense of 9.55 mCi in the case of 3 ml syringe. In the evaluation according to the dispensing rate, the quantity of radioisotope close to 10 mCi was dispensed at the rate of 5 mm/min when the measurement was carried out by increasing the rate by 5 mm/min units in the order of 5, 10, 15 and 20 mm/min . In the evaluation result according to the vial pressure before/after the use of Needle filter, it was measured to be 9.53 mCi before use and 9.84 mCi after use confirming that the dispensing after using Needle filter showed the optimal value. In addition, in the evaluation of radioactivity before/after the application of corrected values according to the increase in dispense frequency, it was measured 9.53 mCi before correction and 10.07 mCi after correction confirming that the value with correction applied was closer to the quantitative value. Thus, a good optimized method was confirmed to use a 3 ml syringe with dispensing rate of 5 mm/min, to use a Needle filter at dispensing, and to set the corrected value of [y = 0.097 × χ] according to the dispensing frequency of equipment.

  9. Note: Digital laser frequency auto-locking for inter-satellite laser ranging.

    Science.gov (United States)

    Luo, Yingxin; Li, Hongyin; Yeh, Hsien-Chi

    2016-05-01

    We present a prototype of a laser frequency auto-locking and re-locking control system designed for laser frequency stabilization in inter-satellite laser ranging system. The controller has been implemented on field programmable gate arrays and programmed with LabVIEW software. The controller allows initial frequency calibrating and lock-in of a free-running laser to a Fabry-Pérot cavity. Since it allows automatic recovery from unlocked conditions, benefit derives to automated in-orbit operations. Program design and experimental results are demonstrated.

  10. Note: Digital laser frequency auto-locking for inter-satellite laser ranging

    International Nuclear Information System (INIS)

    Luo, Yingxin; Yeh, Hsien-Chi; Li, Hongyin

    2016-01-01

    We present a prototype of a laser frequency auto-locking and re-locking control system designed for laser frequency stabilization in inter-satellite laser ranging system. The controller has been implemented on field programmable gate arrays and programmed with LabVIEW software. The controller allows initial frequency calibrating and lock-in of a free-running laser to a Fabry-Pérot cavity. Since it allows automatic recovery from unlocked conditions, benefit derives to automated in-orbit operations. Program design and experimental results are demonstrated.

  11. Note: Digital laser frequency auto-locking for inter-satellite laser ranging

    Energy Technology Data Exchange (ETDEWEB)

    Luo, Yingxin; Yeh, Hsien-Chi, E-mail: yexianji@mail.hust.edu.cn [MOE Key Laboratory of Fundamental Quantities Measurement, School of Physics, Huazhong University of Science and Technology, Wuhan 430074 (China); Li, Hongyin [MOE Key Laboratory of Fundamental Quantities Measurement, School of Physics, Huazhong University of Science and Technology, Wuhan 430074 (China); School of Automation, Huazhong University of Science and Technology, Wuhan 430074 (China)

    2016-05-15

    We present a prototype of a laser frequency auto-locking and re-locking control system designed for laser frequency stabilization in inter-satellite laser ranging system. The controller has been implemented on field programmable gate arrays and programmed with LabVIEW software. The controller allows initial frequency calibrating and lock-in of a free-running laser to a Fabry-Pérot cavity. Since it allows automatic recovery from unlocked conditions, benefit derives to automated in-orbit operations. Program design and experimental results are demonstrated.

  12. Chemotherapy Safe Handling: Limiting Nursing Exposure With a Hazardous Drug Control Program.

    Science.gov (United States)

    Crickman, Rachael

    2017-02-01

    Nurses and other healthcare workers are at risk for adverse health consequences from occupational exposure to hazardous drugs. An evidence-based program for nurses was implemented to improve safe handling practices and reduce exposure to hazardous drugs. A quasiexperimental design was used, with pre- and post-tests of knowledge about chemotherapy exposure and pre- and post-test observations of compliance with donning and doffing personal protective equipment (PPE). Surface wipe tests were conducted to determine hazardous drug contamination in care areas. A toolkit of interventions, including hazardous drug identification, standardization of PPE, and education, was used. Mean knowledge scores of chemotherapy improved after education. Correct donning of PPE was high before and after the intervention, and the correct doffing sequence improved postintervention. One sample was positive for 5-fluorouracil, affirming the difficulty of maintaining an environment free of contamination.

  13. Research on data auto-analysis algorithms in the explosive detection system

    International Nuclear Information System (INIS)

    Wang Haidong; Li Yuanjing; Yang Yigang; Li Tiezhu; Chen Boxian; Cheng Jianping

    2006-01-01

    This paper mainly describe some auto-analysis algorithms in explosive detection system with TNA method. These include the auto-calibration algorithm when disturbed by other factors, MCA auto-calibration algorithm with calibrated spectrum, the auto-fitting and integral of hydrogen and nitrogen elements data. With these numerical algorithms, the authors can automatically and precisely analysis the gamma-spectra and ultimately achieve the explosive auto-detection. (authors)

  14. Susceptibility to hypoxia and breathing control changes after short-term cold exposures

    Directory of Open Access Journals (Sweden)

    Lyudmila T. Kovtun

    2013-08-01

    Full Text Available Background . Hypoxia is the reduction of oxygen availability due to external or internal causes. There is large individual variability of response to hypoxia. Objective . The aim of this study was to define individual and typological features in susceptibility to hypoxia, its interrelation with hypoxic and hypercapnic ventilatory responses (HVR and HCVR, respectively and their changes after cold acclimation. Design . Twenty-four healthy men were tested. HVR and HCVR were measured by the rebreathing method during hypoxic and hypercapnic tests, respectively. These tests were carried out in thermoneutral conditions before and after cold exposures (nude, at 13°C, 2 h daily, for 10 days. Susceptibility to hypoxia (sSaO2 was determined as haemoglobin saturation slope during hypoxic test. Results . It was found that HVR and HCVR significantly increased and susceptibility to hypoxia (sSaO2 tended to decrease after cold acclimation. According to sSaO2 results before cold exposures, the group was divided into 3: Group 1 – with high susceptibility to hypoxia, Group 2 – medium and Group 3 – low susceptibility. Analysis of variances (MANOVA shows the key role of susceptibility to hypoxia and cold exposures and their interrelation. Posterior analysis (Fisher LSD showed significant difference in susceptibility to hypoxia between the groups prior to cold acclimation, while HVR and HCVR did not differ between the groups. After cold acclimation, susceptibility to hypoxia was not significantly different between the groups, while HCVR significantly increased in Groups 1 and 3, HVR significantly increased in Group 3 and HCVR, HVR did not change in Group 2. Conclusions . Short-term cold exposures caused an increase in functional reserves and improved oxygen supply of tissues in Group 1. Cold exposure hypoxia has caused energy loss in Group 3. Group 2 showed the most appropriate energy conservation reaction mode to cold exposures. No relation was found between

  15. Review of Multi-Person Exposure Calls to a Regional Poison Control Center

    Directory of Open Access Journals (Sweden)

    Morgan, Brent W

    2010-08-01

    Full Text Available Objective: Poisoning events, including exposures to hazardous materials, can involve multiple victims. Regional poison centers often are contacted in such events involving multiple victims. Methods: We searched our poison center database over a nine-year time period for all calls involving a poisoning event in which more than two people were exposed to the same substance. We then matched each product to the generic category used by the National Poison Data System. We analyzed this data to find the most frequent substances reported as primary substances in the multiple exposures. Results: We identified 6,695 calls between 2000 and 2008 that had more than two people exposed to the same substance. In these calls, 25,926 people were exposed (3.6% of the 715,701 human exposure calls for this period. These calls involved 64 of the 67 NPDS substance group codes. Some substances were much more commonly involved than others. The top three categories causing the most exposures were Fumes/Gases/Vapors, Food Products/Food Poisoning and Pesticides. Of the patients exposed, 69.4 % were not followed due to minimal effects possible or judged as nontoxic, 0.3% had major effects, 8.6% had no effects, and 9.3% had minimal to moderate effects. Eight people expired. Conclusion: Fumes, gases, and vapors make up the majority of multi-exposure calls. The overall mortality from multi-exposures, based on our data, is low. Analysis of these calls can help poison centers better understand these events and direct training. [West J Emerg Med 2010; 11(3: 292-294.

  16. Susceptibility to hypoxia and breathing control changes after short-term cold exposures.

    Science.gov (United States)

    Kovtun, Lyudmila T; Voevoda, Mikhail I

    2013-01-01

    Hypoxia is the reduction of oxygen availability due to external or internal causes. There is large individual variability of response to hypoxia. The aim of this study was to define individual and typological features in susceptibility to hypoxia, its interrelation with hypoxic and hypercapnic ventilatory responses (HVR and HCVR, respectively) and their changes after cold acclimation. Twenty-four healthy men were tested. HVR and HCVR were measured by the rebreathing method during hypoxic and hypercapnic tests, respectively. These tests were carried out in thermoneutral conditions before and after cold exposures (nude, at 13°C, 2 h daily, for 10 days). Susceptibility to hypoxia (sSaO2) was determined as haemoglobin saturation slope during hypoxic test. It was found that HVR and HCVR significantly increased and susceptibility to hypoxia (sSaO2) tended to decrease after cold acclimation. According to sSaO2 results before cold exposures, the group was divided into 3: Group 1--with high susceptibility to hypoxia, Group 2--medium and Group 3--low susceptibility. Analysis of variances (MANOVA) shows the key role of susceptibility to hypoxia and cold exposures and their interrelation. Posterior analysis (Fisher LSD) showed significant difference in susceptibility to hypoxia between the groups prior to cold acclimation, while HVR and HCVR did not differ between the groups. After cold acclimation, susceptibility to hypoxia was not significantly different between the groups, while HCVR significantly increased in Groups 1 and 3, HVR significantly increased in Group 3 and HCVR, HVR did not change in Group 2. Short-term cold exposures caused an increase in functional reserves and improved oxygen supply of tissues in Group 1. Cold exposure hypoxia has caused energy loss in Group 3. Group 2 showed the most appropriate energy conservation reaction mode to cold exposures. No relation was found between the thermoregulation and the susceptibility to hypoxia.

  17. Auto/ethnography: A Transformative Research Paradigm

    Directory of Open Access Journals (Sweden)

    Sadruddin Bahadur Qutoshi

    2015-12-01

    Full Text Available This paper aims to address the key question, ‘How far autoethnography contributes towards enriching the field of transformative learning?’ Using my lived experiences as a teacher educator/autoethnographer/researcher and contextualizing self/others within a particular socio-pedagogical life courses I build the basis through addressing questions: Why auto/ethnography is one of the most suitable spaces for transformative researchers and to what extent it serves the agenda of envisioning a transformative teacher education. To achieve this objective I use autobiographies, stories, reflections and poems etc. as narratives with multiple logics and genres; pictography as art-based expression; and ethnography as methodological space within multiparadigmatic design space. In so doing autoethnographer has to delve into whole process of research along a continuum of self and beyond within a particular sociocultural context to understand the phenomena at deeper level of consciousness. This transformative paradigm holds a strong basis in the process of research as: re/reading, re/viewing, critically reflecting on self/others, re/writing for meaning making and developing a subjective understanding of phenomena under exploration. This process of research is found to be an innovative way of knowing through ‘interpreting and constructing (Luitel, 2009within Interpretivism, critically thinking and reflecting within Criticalism, and adding both ‘pluralism and playfulness’ (Taylor, 2013 within Postmodernism. In so doing it raises awareness, develops consciousness and improves capacities constantly that ultimately alters our way of seeing and being in the world differently- a paradigm shift in self/others. It is found to be highly rigorous, dialectically eloquent, dialogically rigorous, critically reflective, consciously awakening, and innovative critical discourse that greatly contributes to transform researcher/s. Therefore, it seems illustrious for

  18. Kepler AutoRegressive Planet Search

    Science.gov (United States)

    Feigelson, Eric

    NASA's Kepler mission is the source of more exoplanets than any other instrument, but the discovery depends on complex statistical analysis procedures embedded in the Kepler pipeline. A particular challenge is mitigating irregular stellar variability without loss of sensitivity to faint periodic planetary transits. This proposal presents a two-stage alternative analysis procedure. First, parametric autoregressive ARFIMA models, commonly used in econometrics, remove most of the stellar variations. Second, a novel matched filter is used to create a periodogram from which transit-like periodicities are identified. This analysis procedure, the Kepler AutoRegressive Planet Search (KARPS), is confirming most of the Kepler Objects of Interest and is expected to identify additional planetary candidates. The proposed research will complete application of the KARPS methodology to the prime Kepler mission light curves of 200,000: stars, and compare the results with Kepler Objects of Interest obtained with the Kepler pipeline. We will then conduct a variety of astronomical studies based on the KARPS results. Important subsamples will be extracted including Habitable Zone planets, hot super-Earths, grazing-transit hot Jupiters, and multi-planet systems. Groundbased spectroscopy of poorly studied candidates will be performed to better characterize the host stars. Studies of stellar variability will then be pursued based on KARPS analysis. The autocorrelation function and nonstationarity measures will be used to identify spotted stars at different stages of autoregressive modeling. Periodic variables with folded light curves inconsistent with planetary transits will be identified; they may be eclipsing or mutually-illuminating binary star systems. Classification of stellar variables with KARPS-derived statistical properties will be attempted. KARPS procedures will then be applied to archived K2 data to identify planetary transits and characterize stellar variability.

  19. Evaluation of the workers exposure to heat and presenting intervention to control heat stress in profile factory

    Directory of Open Access Journals (Sweden)

    Motamedzade Majid

    2014-10-01

    Full Text Available Background & Objectives : Exposure to heat is a significant problem in the Industries. The present study aimed at the evaluation of thermal risk, measurement of heat stress index, and proposing a plan for heat control in cutting and welding units in profile factory . Methods : The data of study was analyzed through the measurement of physical parameters with digital WBGT device and silvered Kata thermometer. Workers’ thermal comfort was calculated based on predicted mean voted (PMV and predicted percentage of dissatisfied (PPD with regard to the computed parameters. In order to control heat stress, an aluminum-insulated wall was used and airflow velocity was increased in cutting and welding units. Results : The results of the WBGT index before and after the intervention using the shield were 30.8° C and 23.2° C, and by increasing airflow velocity were 30° C and 29.5° C respectively. In addition, the obtained results for PMV and PPD by using the shield were 1.38 and %44, and by increasing airflow velocity they were %90 and 2.56 respectively. The results confirmed by using the shield the measured WBGT index was lower than the occupational exposure limit (28 ◦ c. Conclusion : The results showed that by appropriate designing and using control methods, such as insulation shield and increased airflow velocity, optimal thermal comfort based on national heat exposure limits could be reached .

  20. The ICRP 66 Internal Radiation Exposure Control and Dose Evaluation of The Institute of Nuclear Energy Research

    International Nuclear Information System (INIS)

    Pang, H. F.; Hwang, W. S.; Chiu, J. H.

    2004-01-01

    The Atomic Energy Council (AEC) is the regulatory body of ionization radiation protection in Taiwan. To effectively control the safety in ionization radiation, AEC brought into force the Ionization Radiation Protection Act on 1 February, 2003 with clear statements of the penalty for violating the Law. The Article 5 of the Act provides: In order to limit the radiation exposure from radiation sources or practices, the Competent Authority shall refer to the latest standards of the International Commission on Radiological Protection to lay down the Safety Standards for Protection against Ionizing Radiation. Thus, AEC is going to draft new safety standards of ionization radiation protection of Taiwan according to ICRP Publication 60. The Institute of Nuclear Energy Research (INER), the governmental institute working on ionization radiation research in Taiwan, took the responsibility of assisting AEC in establishing guidelines on the control of internal radiation exposure and responding to the regulations in the new standards as soon as possible. So, according to the recommendations of ICRP Publications 60, 66,67,68,69,71,78,88, and IAEA Safety Standard Series No. RS-G- 1.1 and 1.2, INER undertook researches on the internal radiation exposure control and dose evaluations for INER's radiation workers as well as dose evaluations for the general public. The research accomplishments not only can be the reference of AEC when making new standards, but also can be followed by other radiation protection businesses. (Author) 23 refs

  1. Revision of NATO standardization agreement (STANAG) 2345 'Evaluation and control of personnel exposure to radio frequency fields'

    International Nuclear Information System (INIS)

    Klauenberg, B.J.; Merritt, J.H.; Gardner, R.

    1996-01-01

    North Atlantic Treaty Organization (NATO) joint operations, which reach across borders of countries that have different standards, could present a logistical nightmare were it not for standardization agreements, called STANAGs. STANAGs are established to provide uniform policies and procedures to insure international cooperation and to maintain the most effective levels of commonalty, compatibility, interchange-ability and inter-operability in military operations. Since signals produced by radar and communications equipment are not contained by national boundaries, a STANAG for Radiofrequency Radiation (RFR) is essential. The STANAG-2345 Control and Evaluation of Personnel Exposure to Radio Frequency Radiation. establishes criteria for the evaluation and control of personnel exposure to radio-frequency radiation within NATO forces. It defines hazard assessment, allows for control measures, indicates actions in case of accidental overexposures and establishes permissible exposure limits. The promulgation of this STANAG in 1979 was the culmination of deliberations among scientists and health professionals within the NATO community that began in May 1973. At the time of adoption it contained guidance based on the then state-of-knowledge. The standard has not been updated since it was issued, despite great advances in the knowledge-base defining health and safety aspects of RFR. Several standards setting groups recently updated their standards, including the American National Standards Institute revised safety guidance for RFR. This has left a large technology gap between the newer standards and STANAG 2345. (author)

  2. Lung cancer risk, exposure to radon and tobacco consumption in a nested case-control study of French uranium miners

    International Nuclear Information System (INIS)

    Leuraud, K.; Billon, S.; Bergot, D.; Tirmarche, M.; Laurier, D.; Caer, S.; Quesne, B.

    2006-01-01

    Introduction: A nested case-control study was conducted among the French uranium miners cohort in order to assess the effect of protract ed radon exposure on lung cancer risk taking into account tobacco consumption. Material and methods: One hundred uranium miners employed by the French company CEA-COGEMA and who died of a lung cancer between 1980 and 1994 were identified as cases among the cohort. For each case, five controls were randomly matched on birth period and attained age at the time of death of the corresponding case. Cumulated radon exposure during employment was reconstructed for each of these 100 cases and 500 controls. Smoking habits were retrospectively determined from three complementary sources: 1) medical files, 2) forms filled in by occupational physicians and 3) questionnaires applied in face-to-face interviews, phone calls or mailings. Analysis was performed by conditional logistic regression using a linear excess relative risk (ERR) model. A multiplicative model was fitted to assess the joint effect of radon exposure and smoking on lung cancer risk. Results: Smoking status was established for 62 cases and 320 controls and two categories ('ever smokers' vs. 'never smokers') were defined. Ninety percent of the cases and 73% of the controls were classified as 'ever smokers'. Mean five-year lagged cumulated radon exposures were 82.0 and 47.6 working level months (WLM) for the cases and the controls, respectively. The excess relative risk per WLM (ERR/WLM) was 1.1% with a 95%-confidence interval (CI) of 0.2-2.0%. When adjusting for smoking, radon exposure effect was little modified (ERR/WLM = 0.8%, 95% -CI = 0.1- 2.8%). The effect of smoking on lung cancer risk was comparable to results reported in previous miners cohorts (OR = 3.04, 95% -CI = 1.20-7.70). Discussion: A consequent effort was carried out to collect smoking status from three sources for the miners included in this nested case-control study. This analysis shows that, when adjusting on

  3. Hormonal exposures and the risk of intracranial meningioma in women: a population-based case-control study

    Directory of Open Access Journals (Sweden)

    Phillips Leslie E

    2006-06-01

    Full Text Available Abstract Background The role of exogenous hormone exposures in the development of meningioma is unclear, but these exposures have been proposed as one hypothesis to explain the over-abundance of such tumors in women. Methods The association between oral contraception (OC or hormone replacement therapy (HRT and intracranial meningioma in women was investigated using a population-based, matched case-control study. Exposures for 143 cases and 286 controls matched on age within five years were obtained by interview. Diagnoses were confirmed histopathologically and estrogen and progesterone receptor assays conducted. Results Although risk of meningioma appeared modestly elevated in past OC users (OR = 1.5, 95% CI 0.8 – 2.7, and in current users (OR = 2.5, 95% CI 0.5 – 12.6, the confidence intervals were wide. No significant association between meningioma risk and duration of OC use was found. Likewise, risk of meningioma was only weakly associated with past use of HRT (OR = 0.7, 95% CI 0.4 – 1.3, and not at all with current use of HRT (OR = 1.0, 95% CI 0.5 – 2.2. Of 142 available specimens, 2 (1% expressed estrogen receptors, whereas 130 (92% expressed progesterone receptors (PR. OC use was associated with increased risk of a meningioma expressing less rather than more PR (OR = 3.2, 95% CI 1.3 – 8.0. Overall, in post menopausal women, HRT use appeared to confer a non-significant protective effect, and was not associated with low or high PR expressing meningiomas. Conclusion This study found little evidence of associations between meningioma and exogenous hormone exposures in women but did suggest that some hormonal exposures may influence tumor biology in those women who develop meningioma.

  4. Hormonal exposures and the risk of intracranial meningioma in women: a population-based case-control study

    International Nuclear Information System (INIS)

    Custer, Brian; Longstreth, WT Jr; Phillips, Leslie E; Koepsell, Thomas D; Van Belle, Gerald

    2006-01-01

    The role of exogenous hormone exposures in the development of meningioma is unclear, but these exposures have been proposed as one hypothesis to explain the over-abundance of such tumors in women. The association between oral contraception (OC) or hormone replacement therapy (HRT) and intracranial meningioma in women was investigated using a population-based, matched case-control study. Exposures for 143 cases and 286 controls matched on age within five years were obtained by interview. Diagnoses were confirmed histopathologically and estrogen and progesterone receptor assays conducted. Although risk of meningioma appeared modestly elevated in past OC users (OR = 1.5, 95% CI 0.8 – 2.7), and in current users (OR = 2.5, 95% CI 0.5 – 12.6), the confidence intervals were wide. No significant association between meningioma risk and duration of OC use was found. Likewise, risk of meningioma was only weakly associated with past use of HRT (OR = 0.7, 95% CI 0.4 – 1.3), and not at all with current use of HRT (OR = 1.0, 95% CI 0.5 – 2.2). Of 142 available specimens, 2 (1%) expressed estrogen receptors, whereas 130 (92%) expressed progesterone receptors (PR). OC use was associated with increased risk of a meningioma expressing less rather than more PR (OR = 3.2, 95% CI 1.3 – 8.0). Overall, in post menopausal women, HRT use appeared to confer a non-significant protective effect, and was not associated with low or high PR expressing meningiomas. This study found little evidence of associations between meningioma and exogenous hormone exposures in women but did suggest that some hormonal exposures may influence tumor biology in those women who develop meningioma

  5. Development of a dose-controlled multiculture cell exposure chamber for efficient delivery of airborne and engineered nanoparticles

    International Nuclear Information System (INIS)

    Asimakopoulou, Akrivi; Daskalos, Emmanouil; Papaioannou, Eleni; Konstandopoulos, Athanasios G; Lewinski, Nastassja; Riediker, Michael

    2013-01-01

    In order to study the various health influencing parameters related to engineered nanoparticles as well as to soot emitted by Diesel engines, there is an urgent need for appropriate sampling devices and methods for cell exposure studies that simulate the respiratory system and facilitate associated biological and toxicological tests. The objective of the present work was the further advancement of a Multiculture Exposure Chamber (MEC) into a dose-controlled system for efficient delivery of nanoparticles to cells. It was validated with various types of nanoparticles (Diesel engine soot aggregates, engineered nanoparticles for various applications) and with state-of-the-art nanoparticle measurement instrumentation to assess the local deposition of nanoparticles on the cell cultures. The dose of nanoparticles to which cell cultures are being exposed was evaluated in the normal operation of the in vitro cell culture exposure chamber based on measurements of the size specific nanoparticle collection efficiency of a cell free device. The average efficiency in delivering nanoparticles in the MEC was approximately 82%. The nanoparticle deposition was demonstrated by Transmission Electron Microscopy (TEM). Analysis and design of the MEC employs Computational Fluid Dynamics (CFD) and true to geometry representations of nanoparticles with the aim to assess the uniformity of nanoparticle deposition among the culture wells. Final testing of the dose-controlled cell exposure system was performed by exposing A549 lung cell cultures to fluorescently labeled nanoparticles. Delivery of aerosolized nanoparticles was demonstrated by visualization of the nanoparticle fluorescence in the cell cultures following exposure. Also monitored was the potential of the aerosolized nanoparticles to generate reactive oxygen species (ROS) (e.g. free radicals and peroxides generation), thus expressing the oxidative stress of the cells which can cause extensive cellular damage or damage on DNA.

  6. Presença de auto-anticorpos não-tireóide-específicos no soro de pacientes com hipotireoidismo auto-imune Presence of nonthyroid-specific autoantibodies in autoimmune hypothyroidism

    Directory of Open Access Journals (Sweden)

    Débora Vieira Soares

    2003-01-01

    Full Text Available Auto-anticorpos contra componentes não-específicos da tireóide foram encontrados no soro de pacientes com doença auto-imune da tireóide. Neste estudo avaliamos a presença de auto-anticorpos antinucleares (ANA, antimúsculo liso (anti-ML e antimitocôndria (anti-Mc no soro de pacientes com hipotireoidismo auto-imune (HA, comparando-os a controles saudáveis. Estudamos 70 pacientes com hipotireoidismo auto-imune (tireoidite de Hashimoto ou tireoidite atrófica e 70 controles saudáveis (sem diagnóstico de doença auto-imune e tireoidiana, todos do sexo feminino, com média de idade de 50,2 anos (+ 15,9 e 49,6 anos (+ 14,4, respectivamente. O ANA, detectado através do sistema Inno-LIA™ ANA (Innogenetics, Bélgica, foi positivo em 26% dos pacientes com HA e em 14% dos controles, não sendo esta diferença significativa (p = 0,09. Não houve diferença entre tempo de doença ou idade entre os grupos ANA positivo ou negativo. Anticorpos anti-ML e anti-Mc foram negativos em todas as amostras, sendo analisados através de imunofluorescência indireta. Concluímos que pacientes com hipotireoidismo auto-imune não apresentaram maior incidência de auto-anticorpos não-específicos para tireóide do que controles saudáveis. Ressaltamos, contudo, que a associação entre doenças auto-imunes da tireóide e outras doenças auto-imunes é fato incontestável, podendo ocorrer em qualquer período no curso de sua evolução. Portanto avaliações regulares são recomendadas.Autoantibodies against nonthyroid-specific components were detected in sera of patients with autoimmune thyroid disease. In this study we investigated the presence of the antinuclear antibody (ANA, antismooth muscle antibody (anti-SM and antimitochondrial antibody (anti-Mc in the sera of patients with autoimmune hypothyroidism comparing them to a control group. We studied 70 patients with autoimmune hypothyroidism (Hashimoto's or atrophic thyroiditis and 70 healthy controls

  7. Sistem Informasi Penjualan Pemasangan Kacafilm “HS Auto Film"

    Directory of Open Access Journals (Sweden)

    Noer Tjahja Moekthi Pratjitana

    2013-07-01

    Full Text Available The growing market share in many business areas especially in service area is causing the use of conventional accounting system being ineffective. One of the companies which still using the conventional one is a window film set-up service company called HS Auto Film. The process of processing sales data is less accurate and slower in the contrary of the developing sales data.  Computer-based window film set-up Sales Information System is built in order to make the processing data more accurate and faster.  The information system is built using Visual Basic programming language along with .NET framework technology and SQL Server database that embedded in the application itself. The making and development process of the Sales Information System is using waterfall method.  Waterfall method consists of user requirement, analysis, design, implementation, and testing. Entity Relationship Diagram, Data Flow Diagram and Flowchart are also used in the Information System design. The output of this application design is a desktop application that can help user to control the set-up of window film, manage payment bill, and manage document in accounting in faster and more accurate way. The information system can be developed later using web-based system so that the development and maintenance can be done easier.

  8. An auto-locked diode laser system for precision metrology

    Science.gov (United States)

    Beica, H. C.; Carew, A.; Vorozcovs, A.; Dowling, P.; Pouliot, A.; Barron, B.; Kumarakrishnan, A.

    2017-05-01

    We present a unique external cavity diode laser system that can be auto-locked with reference to atomic and molecular spectra. The vacuum-sealed laser head design uses an interchangeable base-plate comprised of a laser diode and optical elements that can be selected for desired wavelength ranges. The feedback light to the laser diode is provided by a narrow-band interference filter, which can be tuned from outside the laser cavity to fineadjust the output wavelength in vacuum. To stabilize the laser frequency, the digital laser controller relies either on a pattern-matching algorithm stored in memory, or on first or third derivative feedback. We have used the laser systems to perform spectroscopic studies in rubidium at 780 nm, and in iodine at 633 nm. The linewidth of the 780-nm laser system was measured to be ˜500 kHz, and we present Allan deviation measurements of the beat note and the lock stability. Furthermore, we show that the laser system can be the basis for a new class of lidar transmitters in which a temperature-stabilized fiber-Bragg grating is used to generate frequency references for on-line points of the transmitter. We show that the fiber-Bragg grating spectra can be calibrated with reference to atomic transitions.

  9. Economic benefits of methylmercury exposure control in Europe: Monetary value of neurotoxicity prevention

    DEFF Research Database (Denmark)

    Bellanger, Martine; Pichery, Céline; Aerts, Dominique

    2013-01-01

    was based on lifetime income, adjusted for purchasing power parity. RESULTS: The hair-mercury concentrations were the highest in Southern Europe and lowest in Eastern Europe. The results suggest that, within the EU, more than 1.8 million children are born every year with MeHg exposures above the limit of 0...

  10. Serum vitamin D levels are not altered after controlled diesel exhaust exposures in healthy human subjects

    Science.gov (United States)

    Past research has suggested that exposure to urban air pollution may be associated with vitamin D deficiency in human populations. Vitamin D is widely known for its importance in bone growth/remodeling, muscle metabolism, and its ability to promote calcium absorption in the gut; ...

  11. Diversity of allergen exposure: implications for the efficacy of environmental control.

    Science.gov (United States)

    Segundo, Gesmar Rodrigues Silva; Sopelete, Mônica Camargo; Terra, Sílvia Azevedo; Pereira, Fernando Lourenço; Justino, Caroline Morais; Silva, Deise Aparecida de Oliveira; Taketomi, Ernesto Akio

    2009-01-01

    The prevalence of allergic diseases such as asthma, rhinitis, allergic conjunctivitis and atopic dermatitis has increased in the last decades. The relationship between allergen exposure, atopic sensitization and development of allergic diseases is widely described in the literature. To evaluate measures for reducing allergen exposure as part of the treatment of allergic diseases. An analysis was made of previous studies on allergen exposure done with a similar methodology in the central region of Brazil; the study included homes, hotels, cinemas, cars, taxis, buses and scholar transportation. High levels of Der p 1 and Der f 1 mite allergens were found in a large proportion of the sample in most of the environments included in those studies; there were higher levels of pet allergens in cars and school transportation vehicles. The diversity of allergen exposure demonstrates the need for education about allergic diseases for patients and their families, as well as measures of reducing allergens in homes. This should be part of a global strategy of the management of allergic diseases, given that individuals live in society, not only in their houses.

  12. Control of exposure to exhaled air from sick occupant with wearable personal exhaust unit

    DEFF Research Database (Denmark)

    Bolashikov, Zhecho Dimitrov; Melikov, Arsen Krikor; Barova, Maria I.

    2014-01-01

    Exposure reduction to exhaled air from a sick doctor wearing personal exhaust unit incorporated in headset-microphone was studied. Experiments were performed in a full-scale test room furnished as a double-bed hospital room with overhead ventilation at 3, 6 and 12 ACH. Room air temperature was 22...

  13. Exposures and reactions to allergens among hairdressing apprentices and matched controls

    DEFF Research Database (Denmark)

    Bregnhøj, Anne; Søsted, Heidi; Menné, Torkil

    2011-01-01

    Early and extensive exposures to chemical substances such as are found in hair dyes, perfumes and nickel are known risk factors for allergic reactions. Hairdressing apprentices belong to a high-risk group, as they are exposed both occupationally and personally....

  14. Biochemical Tolerance During Low Dose Propylene Glycol Exposure in Neonates: A Formulation-Controlled Evaluation

    Directory of Open Access Journals (Sweden)

    Aida Kulo

    2012-07-01

    Full Text Available Background and purpose of the study: Propylene glycol (PG is a frequently co-administered solvent in formulations administered to neonates, but reports on its (intolerance are limited. We aimed to report on renal, metabolic and hepatic tolerance before, during and following intravenous (iv PG-paracetamol exposure and compared these data with similar datasets reported in literature on neonates exposed to PG without paracetamol or paracetamol without PG.Methods: Renal (diuresis, creatinemia, sodium, metabolic (Base Excess, Anion Gap, lactate, bicarbonate and hepatic (liver enzymes, bilirubinemia indicators before, during and following iv paracetamol-PG exposure in neonates as included in the PARANEO (paracetamol in neonates study (intra-individual trends, ANOVA were collected and analysed.Comparison with observations collected in cases exposed to either iv phenobarbital-PG or iv paracetamol-mannitol (inter-individual comparison, Mann Whitney-U test were made. Results: PG exposure (median 34.1 mg/kg/24 h did not affect postnatal renal, metabolic and hepatic adaptations in 60 cases exposed to paracetamol-PG. These indicators were similar when compared to 29 cases exposed to phenobarbital- PG or 172 cases exposed to paracetamol-mannitol.Major conclusion: Based on observations in 89 neonates, low dose PG exposure was tolerated well. Studies on PG pharmacokinetics and its covariates are needed to estimate the upper level of PG tolerance in neonates.

  15. Spatiotemporal air pollution exposure assessment for a Canadian population-based lung cancer case-control study

    Directory of Open Access Journals (Sweden)

    Hystad Perry

    2012-04-01

    Full Text Available Abstract Background Few epidemiological studies of air pollution have used residential histories to develop long-term retrospective exposure estimates for multiple ambient air pollutants and vehicle and industrial emissions. We present such an exposure assessment for a Canadian population-based lung cancer case-control study of 8353 individuals using self-reported residential histories from 1975 to 1994. We also examine the implications of disregarding and/or improperly accounting for residential mobility in long-term exposure assessments. Methods National spatial surfaces of ambient air pollution were compiled from recent satellite-based estimates (for PM2.5 and NO2 and a chemical transport model (for O3. The surfaces were adjusted with historical annual air pollution monitoring data, using either spatiotemporal interpolation or linear regression. Model evaluation was conducted using an independent ten percent subset of monitoring data per year. Proximity to major roads, incorporating a temporal weighting factor based on Canadian mobile-source emission estimates, was used to estimate exposure to vehicle emissions. A comprehensive inventory of geocoded industries was used to estimate proximity to major and minor industrial emissions. Results Calibration of the national PM2.5 surface using annual spatiotemporal interpolation predicted historical PM2.5 measurement data best (R2 = 0.51, while linear regression incorporating the national surfaces, a time-trend and population density best predicted historical concentrations of NO2 (R2 = 0.38 and O3 (R2 = 0.56. Applying the models to study participants residential histories between 1975 and 1994 resulted in mean PM2.5, NO2 and O3 exposures of 11.3 μg/m3 (SD = 2.6, 17.7 ppb (4.1, and 26.4 ppb (3.4 respectively. On average, individuals lived within 300 m of a highway for 2.9 years (15% of exposure-years and within 3 km of a major industrial emitter for 6.4 years (32% of exposure-years. Approximately 50

  16. Yohimbine enhancement of exposure therapy for social anxiety disorder: a randomized controlled trial.

    Science.gov (United States)

    Smits, Jasper A J; Rosenfield, David; Davis, Michelle L; Julian, Kristin; Handelsman, Pamela R; Otto, Michael W; Tuerk, Peter; Shiekh, Michael; Rosenfield, Ben; Hofmann, Stefan G; Powers, Mark B

    2014-06-01

    Preclinical and clinical trials suggest that yohimbine may augment extinction learning without significant side effects. However, previous clinical trials have only examined adults with specific phobias. Yohimbine has not yet been investigated in the augmentation of exposure therapy for other anxiety disorders. Adults (n = 40) with a DSM-IV diagnosis of social anxiety disorder were randomized to placebo or yohimbine HCl (10.8 mg) 1 hour before each of four exposure sessions. Outcome measures were collected at baseline, each treatment session, posttreatment, and 1-month follow-up. Yohimbine was well tolerated. Yohimbine augmentation, relative to placebo augmentation, resulted in faster improvement and better outcomes on self-report measures of social anxiety disorder severity (Liebowitz Social Anxiety Scale, d = .53) and depressed mood severity (Beck Depression Inventory, d = .37) but not on the clinician-rated measures (Clinical Global Impressions-Severity Scale, d = .09; Clinical Global Impressions-Improvement Scale, d = .25). Between-group differences on the Liebowitz Social Anxiety Scale were moderated by the level of fear reported at the end of an exposure exercise (end fear), such that the advantage of yohimbine over placebo was only evident among patients who reported low end fear. The results provide moderate support for yohimbine as a therapeutic augmentation strategy for exposure therapy in social anxiety disorder, one that may be especially effective when coupled with successful exposure experiences. Beneficial effects for yohimbine were readily evident for self-report measures but not for clinician-rated outcomes of social anxiety severity and improvement. © 2013 Society of Biological Psychiatry Published by Society of Biological Psychiatry All rights reserved.

  17. Exposure to the Riot Control Agent CS and Potential Health Effects: A Systematic Review of the Evidence

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    Yiannis Dimitroglou

    2015-01-01

    Full Text Available o-Chlorobenzylidene malononitrile (CS is one of the most extensively used riot control agents. Our aim was to conduct a systematic review of the potential health effects related to CS exposure. We searched for papers in English between 1991 and 2014. Thirty five (35 studies (25 case reports, seven descriptive studies and three analytical studies were included in the review. In the twenty five case reports/series 90 cases of exposure to CS and their clinical effects are presented. Their mean age was 25.7 years and 62.0% were males. In addition, 61% of the cases described dermal, 40% respiratory, 57% ocular clinical effects. Life threatening situations as well as long-term health effects were found and were related with exposure to confined/enclosed space. Descriptive and analytical studies have shown attack rates ranging from 12% to 40%. Subjects who were sprayed by the police more often needed special treatment and reported adverse health effects. Apart from transient clinical effects, CS could have lasting and serious effects on human health. Better surveillance of the subjects exposed to CS and completion of cohort studies among exposed populations will illuminate the spectrum of the health effects of exposure to CS.

  18. Exposure to the riot control agent CS and potential health effects: a systematic review of the evidence.

    Science.gov (United States)

    Dimitroglou, Yiannis; Rachiotis, George; Hadjichristodoulou, Christos

    2015-01-27

    o-Chlorobenzylidene malononitrile (CS) is one of the most extensively used riot control agents. Our aim was to conduct a systematic review of the potential health effects related to CS exposure. We searched for papers in English between 1991 and 2014. Thirty five (35) studies (25 case reports, seven descriptive studies and three analytical studies) were included in the review. In the twenty five case reports/series 90 cases of exposure to CS and their clinical effects are presented. Their mean age was 25.7 years and 62.0% were males. In addition, 61% of the cases described dermal, 40% respiratory, 57% ocular clinical effects. Life threatening situations as well as long-term health effects were found and were related with exposure to confined/enclosed space. Descriptive and analytical studies have shown attack rates ranging from 12% to 40%. Subjects who were sprayed by the police more often needed special treatment and reported adverse health effects. Apart from transient clinical effects, CS could have lasting and serious effects on human health. Better surveillance of the subjects exposed to CS and completion of cohort studies among exposed populations will illuminate the spectrum of the health effects of exposure to CS.

  19. Quality control and statistical modeling for environmental epigenetics: a study on in utero lead exposure and DNA methylation at birth.

    Science.gov (United States)

    Goodrich, Jaclyn M; Sánchez, Brisa N; Dolinoy, Dana C; Zhang, Zhenzhen; Hernández-Ávila, Mauricio; Hu, Howard; Peterson, Karen E; Téllez-Rojo, Martha M

    2015-01-01

    DNA methylation data assayed using pyrosequencing techniques are increasingly being used in human cohort studies to investigate associations between epigenetic modifications at candidate genes and exposures to environmental toxicants and to examine environmentally-induced epigenetic alterations as a mechanism underlying observed toxicant-health outcome associations. For instance, in utero lead (Pb) exposure is a neurodevelopmental toxicant of global concern that has also been linked to altered growth in human epidemiological cohorts; a potential mechanism of this association is through alteration of DNA methylation (e.g., at growth-related genes). However, because the associations between toxicants and DNA methylation might be weak, using appropriate quality control and statistical methods is important to increase reliability and power of such studies. Using a simulation study, we compared potential approaches to estimate toxicant-DNA methylation associations that varied by how methylation data were analyzed (repeated measures vs. averaging all CpG sites) and by method to adjust for batch effects (batch controls vs. random effects). We demonstrate that correcting for batch effects using plate controls yields unbiased associations, and that explicitly modeling the CpG site-specific variances and correlations among CpG sites increases statistical power. Using the recommended approaches, we examined the association between DNA methylation (in LINE-1 and growth related genes IGF2, H19 and HSD11B2) and 3 biomarkers of Pb exposure (Pb concentrations in umbilical cord blood, maternal tibia, and maternal patella), among mother-infant pairs of the Early Life Exposures in Mexico to Environmental Toxicants (ELEMENT) cohort (n = 247). Those with 10 μg/g higher patella Pb had, on average, 0.61% higher IGF2 methylation (P = 0.05). Sex-specific trends between Pb and DNA methylation (P < 0.1) were observed among girls including a 0.23% increase in HSD11B2 methylation with 10

  20. Exposure to Genocide as a Risk Factor for Homicide Perpetration in Rwanda: A Population-Based Case-Control Study.

    Science.gov (United States)

    Rubanzana, Wilson; Hedt-Gauthier, Bethany L; Ntaganira, Joseph; Freeman, Michael D

    2015-12-16

    A population-based case-control study was conducted to assess the relationship between genocide exposure and homicide perpetration in Rwanda. A sample of 150 homicide perpetrators who were charged with and confessed to having committed homicide between 1 May 2011 and 31 May 2013 and 450 controls were enrolled. Cases were matched to controls by neighborhood, age and sex. Socio-demographic, background and genocide-related information was collected from study subjects' next of kin. Four characteristics of genocide exposure were: genocide survivor, genocide perpetrator, having lost a first-degree relative to genocide and having a first-degree relative convicted of genocide. We assessed the impact of each genocide-exposure variable using conditional logistic regression. Of the 150 cases, 124 (82.7%) were male and 26 (17.3%) were female. The mean age of the alleged homicide perpetrators was 33 years, with a peak in the age group 20-29 years (39.3%). After adjusting for socio-demographic characteristics and past common criminal records, having a first-degree relative who had been convicted of genocide crimes was a significant predictor for homicide perpetration (odds ratio [OR] = 14.4, 95% confidence interval [CI] = 1.6-129.4). Being a genocide perpetrator, a genocide survivor and having lost a first-degree family member to genocide were not identified as risk factors for homicide perpetration. In Rwanda, young people who experienced early exposure to trauma by witnessing their first-degree relatives' active participation in the genocide, are more likely to commit homicide. Socio-economic and psychotherapeutic programs targeting this population group are needed to rehabilitate these young people for violent behavior change. © The Author(s) 2015.