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Sample records for austin pet centre

  1. Cyclotron-produced radioisotopes and their clinical use at the Austin PET Centre

    Energy Technology Data Exchange (ETDEWEB)

    Tochon-Danguy, H.J. [Centre for PET, Melbourne, VIC (Australia). Austin and Repatriation Medical Centre

    1997-12-31

    A Centre for Positron Emission Tomography (PET) has been established within the Department of Nuclear Medicine at the Austin and Repatriation Medical Centre in Melbourne. PET is a non-invasive technique based on the use of biologically relevant compounds labelled with short-lived positron-emitting radionuclides such as carbon-11, nitrogen-13, oxygen-15 and fluorine-18. The basic equipment consists of a medical cyclotron (10 MeV proton and 5 MeV deuteron), six lead-shielded hot cells with associated radiochemistry facilities and a whole body PET scanner. During its first five years of operation, the Melbourne PET Centre, has pursued a strong radiolabelling development program, leading to an ambitious clinical program in neurology, oncology and cardiology. This presentation will describe the basic principles of the PET technique and review the cyclotron-produced radioisotopes and radiopharmaceuticals. Radiolabelling development programs and clinical applications are also addressed. 30 refs., 1 tab., 1 fig.

  2. Cyclotron-produced radioisotopes and their clinical use at the Austin PET Centre

    International Nuclear Information System (INIS)

    A Centre for Positron Emission Tomography (PET) has been established within the Department of Nuclear Medicine at the Austin and Repatriation Medical Centre in Melbourne. PET is a non-invasive technique based on the use of biologically relevant compounds labelled with short-lived positron-emitting radionuclides such as carbon-11, nitrogen-13, oxygen-15 and fluorine-18. The basic equipment consists of a medical cyclotron (10 MeV proton and 5 MeV deuteron), six lead-shielded hot cells with associated radiochemistry facilities and a whole body PET scanner. During its first five years of operation, the Melbourne PET Centre, has pursued a strong radiolabelling development program, leading to an ambitious clinical program in neurology, oncology and cardiology. This presentation will describe the basic principles of the PET technique and review the cyclotron-produced radioisotopes and radiopharmaceuticals. Radiolabelling development programs and clinical applications are also addressed

  3. Radiopharmaceuticals in positron emission tomography: Radioisotope productions and radiolabelling procedures at the Austin and Repatriation Medical Centre

    Energy Technology Data Exchange (ETDEWEB)

    Tochon-Danguy, H.J.; Sachinidis, J.I.; Chan, J.G.; Cook, M. [Austin and Repatriation Medical Centre, Melbourne, VIC (Australia). Centre for Positron Emission Tomography

    1997-10-01

    Positron Emission Tomography (PET) is a technique that utilizes positron-emitting radiopharmaceuticals to map the physiology, biochemistry and pharmacology of the human body. Positron-emitting radioisotopes produced in a medical cyclotron are incorporated into compounds that are biologically active in the body. A scanner measures radioactivity emitted from a patient`s body and provides cross-sectional images of the distribution of these radiolabelled compounds in the body. It is the purpose of this paper to review the variety of PET radiopharmaceuticals currently produced at the Austin and Repatriation Medical Centre in Melbourne. Radioisotope production, radiolabelling of molecules and quality control of radiopharmaceuticals will be discussed. A few examples of their clinical applications will be shown as well. During the last five years we achieved a reliable routine production of various radiopharmaceuticals labelled with the four most important positron-emitters: oxygen-15 (t,{sub 1/2}=2min), nitrogen-13 (t{sub 1/2}= 10 min), carbon-11 (t{sub 1/2}=20 min) and fluorine-18 (t{sub 1/2}= 110 min). These radiopharmaceuticals include [{sup 15}O]oxygen, [{sup 15}O]carbon monoxide, [{sup 15}O]carbon dioxide, [{sup 15}O]water, [{sup 13}N]ammonia, [{sup 11}C]flumazenil, [{sup 11}C]SCH23390, [{sup 18}F]fluoromisonidazole and [{sup 18}F]fluoro-deoxy-glucose ([{sup 18}F]FDG). In addition, since the half life of [{sup 18}F] is almost two hours, regional distribution can be done, and the Austin and Repatriation Medical Centre is currently supplying [{sup 18}F]FDG in routine to other hospitals. Future new radiopharmaceuticals development include a [{sup 18}F]thymidine analog to measure cell proliferation and a [{sup 11}C]pyrroloisoquinoline to visualize serotonergic neuron abnormalities. (authors) 23 refs., 2 tabs.

  4. Production, administration and disposal of cyclotron produced shortlived radioactive gases for positron emission tomography studies at the Austin Repatriation Medical Centre, Melbourne

    International Nuclear Information System (INIS)

    Positron Emission Tomography (PET) Centre is operational at the Austin Repatriation Medical Centre, Melbourne. The major equipment consists of a 10 MeV cyclotron and a whole body PET scanner. Radioactive gases produced and used directly in clinical studies include [15O]O2, [15O]CO, and [15O]CO2, whilst [11C]CO2 is also produced for use in radiochemistry syntheses. Radioactivity delivery rates of 3.7, 3.3, and 1.6 GBq/min to the scanner suite have been achieved for [15O]O2, [15O]CO2, and [15O]CO respectively, and batch productions of 36.3 GBq of [11C]CO2 have been produced. The production. patient administration and disposal of the short-lived radioactive gases has been achieved in compliance with radiation protection principles. Radioactive gas doses of 1.7 GBq are administered to patients with less than 0.02 MBq/m3 leakage into the scanner suite. Less than 13 MBq of [ 15O]-labelled gases are released into the environment per patient study at a concentration of 0.018 MBq/m3. Annually less than 2 GBq is expected to be released into the environment. The centre design and first four months' experience of radioactive gas production, administration and disposal is presented. 5 refs., 4 tab., 1 fig

  5. PET Centre and Centre for Functionally Integrative Neuroscience, Aarhus University

    DEFF Research Database (Denmark)

    Cumming, Paul; Pedersen, Mads Damgaard; Minuzzi, Luciano;

    2006-01-01

    The cerebral distribution of peripheral-type benzodiazepine binding sites (PBBS) in human brain has been investigated by positron emission tomography (PET) with the specific radioligand [11C]PK11195 in diverse neuropathological conditions. However, little is known about the pattern of PK11195 bin...

  6. Practical use and implementation of PET in children in a hospital PET centre

    DEFF Research Database (Denmark)

    Borgwardt, Lise; Larsen, Helle Jung; Pedersen, Kate;

    2003-01-01

    Children are not just small adults-they differ in their psychology, normal physiology and pathophysiology, and various aspects should be considered when planning a positron emission tomography (PET) scan in a child. PET in children is a growing area, and this article describes the practical use...... and implementation of PET in children in a hospital PET centre. It is intended to be of use to nuclear medicine departments implementing or starting to implement PET scans in children. Topics covered are: dealing with children, dosimetry, organisation within the department and relations with other departments......, preparation of the child (provision of information to the child and parents and the fasting procedure), the imaging procedure (resting, tracer injection, positioning, sedation and bladder emptying) and pitfalls in the interpretation of PET scans in children, including experiences with telemedicine....

  7. Practical use and implementation of PET in children in a hospital PET centre

    Energy Technology Data Exchange (ETDEWEB)

    Borgwardt, Lise; Larsen, Helle Jung; Pedersen, Kate; Hoejgaard, Liselotte [Department of Clinical Physiology, Nuclear Medicine and PET, University Hospital of Copenhagen, Rigshospitalet, Blegdamsvej 9, 2100, Copenhagen (Denmark)

    2003-10-01

    Children are not just small adults - they differ in their psychology, normal physiology and pathophysiology, and various aspects should be considered when planning a positron emission tomography (PET) scan in a child. PET in children is a growing area, and this article describes the practical use and implementation of PET in children in a hospital PET centre. It is intended to be of use to nuclear medicine departments implementing or starting to implement PET scans in children. Topics covered are: dealing with children, dosimetry, organisation within the department and relations with other departments, preparation of the child (provision of information to the child and parents and the fasting procedure), the imaging procedure (resting, tracer injection, positioning, sedation and bladder emptying) and pitfalls in the interpretation of PET scans in children, including experiences with telemedicine. (orig.)

  8. Practical use and implementation of PET in children in a hospital PET centre

    International Nuclear Information System (INIS)

    Children are not just small adults - they differ in their psychology, normal physiology and pathophysiology, and various aspects should be considered when planning a positron emission tomography (PET) scan in a child. PET in children is a growing area, and this article describes the practical use and implementation of PET in children in a hospital PET centre. It is intended to be of use to nuclear medicine departments implementing or starting to implement PET scans in children. Topics covered are: dealing with children, dosimetry, organisation within the department and relations with other departments, preparation of the child (provision of information to the child and parents and the fasting procedure), the imaging procedure (resting, tracer injection, positioning, sedation and bladder emptying) and pitfalls in the interpretation of PET scans in children, including experiences with telemedicine. (orig.)

  9. Monitoring of occupationally exposed workers in a PET-centre

    International Nuclear Information System (INIS)

    A PET-Centre is jointly run with the technical university Dresden (TUD) at the research location Rossendorf. The deployed, short-lived positron emitters are also produced on the location. Apart from the medical applications extensive research projects take place. Workers in this area are occupationally exposed. About 35 persons which are directly involved in the production, processing and application of the radioactive substances, are monitored by official film dosimeters organised by the department of radiation protection-person / Incorporation Surveillance Station. In addition to the workers from the research centre, those operating in the PET-centre of the TUD are routinely monitored by means of operational, self-reading dosimeters, partial-body dosimeters (hands) and incorporation surveillance. The corresponding working areas require well adapted monitoring methods. While direct radiation is the main contributor to the exposure during the production process in the PET-Cyclotron (film dosimeter values), the main attention during the processing and application has to be focussed on partial-body exposure. Investigations on the local distribution of exposure confirmed a conversion factor 2 between dosimeter location and site of greatest exposure as derived in former in previous investigations. Continued repeated operations can cause exposures close to the dose limit of 500 mSv for the hands. According to experiences up to now, incorporations (determined both by random measurements and measurements after interventions, semi-annually at the accelerator) will cause negligible contributions to the exposure in the routine operation. (orig.)

  10. BIONT - A new centre for PET radiopharmaceuticals production in central Europe

    International Nuclear Information System (INIS)

    BIONT a.s. is a joint stock company that was established in January 2005 as a 'ready to act' facility constructed as a part of Slovakia's cyclotron centre. All its facilities represent state of the art technology for research and production of radionuclides for PET. The layout of the facility was designed for a dual beam cyclotron Cyclone 18/9 and GMP zone for producing PET radiopharmaceuticals. Core parts of the facility were built with the help of the IAEA under two technical cooperation grants during 1997- 2004. Cyclone 18/9 is equipped with six targets: two aqueous targets for 18F- (Nb and Ag), one gas target for 18F2 production, an aqueous target for 13N, and a gas target each for 15O2 and 11CO2. An external beam is constructed for a solid target. The production area includes eight lead shielded boxes with new modules for 2-[18F]FDG and [18F]DOPA synthesis, a dry methylation module for preparation of 11C-methyliodide precursor, a system designed for [13N]NH3 and [15O]H2O production, an automatic dispensing unit, and all necessary auxiliary equipment. A quality control laboratory is equipped with GC, HPLC, TLC scanner, UV-VIS spectrometer, gamma spectrometer and LAL test equipment. A radiopharmaceuticals R and D laboratory is equipped with two shielded chambers, a mini-cell for synthesis modules, and a dispensing cell for an automatic dispensing module. The LC-MS system is dedicated to precursors and radiopharmaceutical analysis. The laboratory also includes a laminar shielded box with dose calibrator, centrifuge, lyophilizer, ultra pure water production unit and other laboratory equipment. The adjacent PET centre, built as a nuclear medicine clinic equipped both with PET/CT and SPECT/CT, allows PET diagnostics also with ultra short lived tracers such as 11C, 13N, and 15O. The design of the microPET unit will also be able to use the same radionuclides. All units are directed under the systems of GMP, good automated manufacturing practice, good practice of

  11. El ave mascota: desde el criadero a la pet-shop - de la pet-shop a la casa - The pet-bird: from the breeding centre to the pet-shop. From the pet- shop to home

    Directory of Open Access Journals (Sweden)

    Dra Elena Bert.

    2011-02-01

    Full Text Available ResumenConocer cuales son los factores que más afectan al ave de jaulaen su recorrido de vida desde el criadero hasta el hogar donde serámantenida como ave mascota, cuales pueden ser las principales patologías detectadas en ese transito y como evitarlas, es el objetivo de este articulo que intenta lograr se establezcan normativas que permitan mantener integra la salud y el bienestar de las aves, desde el criadero hasta la casa.SummaryIn this article we evaluate the factors that can affect the birds ofcage in the breeding farm, as well as in the pet-shop, where they will be kept as pet birds. We expose the main pathologies that can emerge in the birds during the transportation or caused by the habitat changes. We suggest some measures to detect and control clinical signs, and we try to establish some regulations to guarantee the health and wellness of the birds from the breeding centre to home.

  12. Clinical importance of re-interpretation of PET/CT scanning in patients referred to a tertiary care medical centre

    DEFF Research Database (Denmark)

    Löfgren, Johan; Loft, Annika; Barbosa de Lima, Vinicius Araújo;

    2015-01-01

    PURPOSE: To evaluate, in a controlled prospective manner with double-blind read, whether there are differences in interpretations of PET/CT scans at our tertiary medical centre, Rigshospitalet, compared to the external hospitals. METHODS: Ninety consecutive patients referred to our department who...... had an external F-18-FDG PET/CT scan were included. Only information that had been available at the time of the initial reading at the external hospital was available at re-interpretation. Teams with one radiologist and one nuclear medicine physician working side by side performed the re...

  13. PET

    DEFF Research Database (Denmark)

    Mariager, Rasmus Mølgaard; Schmidt, Regin; Heiberg, Morten Rievers

    PET handler om den hemmelige tjenestes arbejde under den kolde krig 1945-1989. Her fortæller Regin Schmidt, Rasmus Mariager og Morten Heiberg om de mest dramatiske og interessante sager fra PET's arkiv. PET er på flere måder en udemokratisk institution, der er sat til at vogte over demokratiet....... Dens virksomhed er skjult for offentligheden, den overvåger borgernes aktiviteter, og den registrerer følsomme personoplysninger. Historien om PET rejser spørgsmålet om, hvad man skal gøre, når befolkningen i et demokrati er kritisk indstillet over for overvågningen af lovlige politiske aktiviteter......, mens myndighederne mener, at det er nødvendigt for at beskytte demokratiet. PET er på en gang en fortælling om konkrete aktioner og begivenheder i PET's arbejde og et stykke Danmarkshistorie. Det handler om overvågning, spioner, politisk ekstremisme og international terrorisme.  ...

  14. Thyroid lesions incidentally detected by 18F-FDG PET-CT ― a two centre retrospective study

    Directory of Open Access Journals (Sweden)

    Jamsek Jan

    2015-06-01

    Full Text Available Background. Incidental 18F-FDG uptake in the thyroid on PET-CT examinations represents a diagnostic challenge. The maximal standardized uptake value (SUVmax is one possible parameter that can help in distinguishing between benign and malignant thyroid PET lesions.

  15. Impact of {sup 11}C-choline PET/CT on clinical decision making in recurrent prostate cancer: results from a retrospective two-centre trial

    Energy Technology Data Exchange (ETDEWEB)

    Ceci, Francesco [University of Bologna, Service of Nuclear Medicine, Policlinico S. Orsola-Malpighi, Bologna (Italy); Universitaetsklinikum Wuerzburg, Department of Nuclear Medicine, Wuerzburg (Germany); Azienda Ospedaliero-Universitaria di Bologna, Policlinico S. Orsola-Malpighi, Bologna (Italy); Herrmann, Ken; Bluemel, Christina; Droll, Sabine; Buck, Andreas K. [Universitaetsklinikum Wuerzburg, Department of Nuclear Medicine, Wuerzburg (Germany); Castellucci, Paolo; Graziani, Tiziano; Fanti, Stefano [University of Bologna, Service of Nuclear Medicine, Policlinico S. Orsola-Malpighi, Bologna (Italy); Schiavina, Riccardo; Brunocilla, Eugenio [University of Bologna, Department of Urology, Policlinico S. Orsola-Malpighi, Bologna (Italy); Vollmer, Christian [Universitaetsklinikum Wuerzburg, Department of Urology, Wuerzburg (Germany); Mazzarotto, Renzo [University of Bologna, Service of Radiotherapy, Policlinico S. Orsola-Malpighi, Bologna (Italy)

    2014-12-15

    The aim of this retrospective two-centre study was to investigate the clinical impact of {sup 11}C-choline PET/CT on treatment management decisions in patients with recurrent prostate cancer (rPCa) after radical therapy. Enrolled in this retrospective study were 150 patients (95 from Bologna, 55 from Wuerzburg) with rPCa and biochemical relapse (PSA mean ± SD 4.3 ± 5.5 ng/mL, range 0.2-39.4 ng/mL) after radical therapy. The intended treatment before PET/CT was salvage radiotherapy of the prostatic bed in 95 patients and palliative androgen deprivation therapy (ADT) in 55 patients. The effective clinical impact of {sup 11}C-choline PET/CT was rated as major (change in therapeutic approach), minor (same treatment, but modified therapeutic strategy) or none. Multivariate binary logistic regression analysis included PSA level, PSA kinetics, ongoing ADT, Gleason score, TNM, age and time to relapse. Changes in therapy after {sup 11}C-choline PET/CT were implemented in 70 of the 150 patients (46.7 %). A major clinical impact was observed in 27 patients (18 %) and a minor clinical impact in 43 (28.7 %). {sup 11}C-choline PET/CT was positive in 109 patients (72.7 %) detecting local relapse (prostate bed and/or iliac lymph nodes and/or pararectal lymph nodes) in 64 patients (42.7 %). Distant relapse (paraaortic and/or retroperitoneal lymph nodes and/or bone lesions) was seen in 31 patients (20.7 %), and both local and distant relapse in 14 (9.3 %). A significant difference was observed in PSA level and PSA kinetics between PET-positive and PET-negative patients (p < 0.05). In multivariate analysis, PSA level, PSA doubling time and ongoing ADT were significant predictors of a positive scan (p < 0.05). In statistical analysis no significant differences were observed between the Bologna and Wuerzburg patients (p > 0.05). In both centres the same criteria to validate PET-positive findings were used: in 17.3 % of patients by histology and in 82.7 % of patients by correlative

  16. EnviroAtlas - Austin, TX - Block Groups

    Data.gov (United States)

    U.S. Environmental Protection Agency — This EnviroAtlas dataset is the base layer for the Austin, TX EnviroAtlas area. The block groups are from the US Census Bureau and are included/excluded based on...

  17. Austin, Texas: Solar in Action (Brochure)

    Energy Technology Data Exchange (ETDEWEB)

    2011-10-01

    This brochure provides an overview of the challenges and successes of Austin, Texas, a 2007 Solar America City awardee, on the path toward becoming a solar-powered community. Accomplishments, case studies, key lessons learned, and local resource information are given.

  18. Austin Community College Video Game Development Certificate

    Science.gov (United States)

    McGoldrick, Robert

    2008-01-01

    The Video Game Development program is designed and developed by leaders in the Austin video game development industry, under the direction of the ACC Video Game Advisory Board. Courses are taught by industry video game developers for those who want to become video game developers. The program offers a comprehensive approach towards learning what's…

  19. Prospective evaluation of 68Ga-DOTA-NOC PET-CT in phaeochromocytoma and paraganglioma: preliminary results from a single centre study

    International Nuclear Information System (INIS)

    To evaluate the role of 68Ga-labelled [1, 4, 7, 10-tetraazacyclododecane-1, 4, 7, 10-tetraacetic acid]-1-NaI3-Octreotide (68Ga-DOTA-NOC) whole body positron emission tomography-computed tomography (PET-CT) as a functional imaging approach for phaeochromocytoma and paraganglioma. Thirty-five unrelated patients (Median age-34.4 years; range: 15-71) were evaluated in this prospective study. PET-CT was performed after injection of 132-222 MBq of 68Ga-DOTA-NOC. Images were evaluated by two experienced nuclear medicine physicians both qualitatively as well as quantitatively (standardised uptake value-SUVmax). In addition we compared the findings with 131I Metaiodobenzylguanidine (MIBG) scintigraphy, which was available for 25 patients. Histopathology and/or conventional imaging with biochemical markers were taken as the reference standard. 44 lesions were detected on 68Ga-DOTA-NOC PET-CT imaging with an additional detection of 12 lesions not previously known, leading to a change in management of 6 patients. Sensitivity, specificity and accuracy were 100%, 85.7%, and 97.1% on a per patient basis and 100%, 85.7% and 98% on per lesion basis, respectively.131I MIBG scintigraphy was concordant with 68Ga-DOTA-NOC PET-CT in 16 patients and false negative in 9 patients. 68Ga-DOTA-NOC PET-CT is highly sensitive and specific for the detection of phaeochromoctyomas and paragangliomas. It seems better than 131I MIBG scintigraphy for this purpose. (orig.)

  20. Prospective evaluation of {sup 68}Ga-DOTA-NOC PET-CT in phaeochromocytoma and paraganglioma: preliminary results from a single centre study

    Energy Technology Data Exchange (ETDEWEB)

    Naswa, Niraj; Sharma, Punit; Nazar, Aftab Hasan; Agarwal, Krishan Kant; Kumar, Rakesh; Malhotra, Arun; Bal, Chandrasekhar [All India Institute of Medical Sciences, Department of Nuclear Medicine, Ansari Nagar, New Delhi (India); Ammini, Ariachery C. [All India Institute of Medical Sciences, Department of Endocrinology and Metabolism, New Delhi (India)

    2012-03-15

    To evaluate the role of {sup 68}Ga-labelled [1, 4, 7, 10-tetraazacyclododecane-1, 4, 7, 10-tetraacetic acid]-1-NaI{sup 3}-Octreotide ({sup 68}Ga-DOTA-NOC) whole body positron emission tomography-computed tomography (PET-CT) as a functional imaging approach for phaeochromocytoma and paraganglioma. Thirty-five unrelated patients (Median age-34.4 years; range: 15-71) were evaluated in this prospective study. PET-CT was performed after injection of 132-222 MBq of {sup 68}Ga-DOTA-NOC. Images were evaluated by two experienced nuclear medicine physicians both qualitatively as well as quantitatively (standardised uptake value-SUVmax). In addition we compared the findings with {sup 131}I Metaiodobenzylguanidine (MIBG) scintigraphy, which was available for 25 patients. Histopathology and/or conventional imaging with biochemical markers were taken as the reference standard. 44 lesions were detected on {sup 68}Ga-DOTA-NOC PET-CT imaging with an additional detection of 12 lesions not previously known, leading to a change in management of 6 patients. Sensitivity, specificity and accuracy were 100%, 85.7%, and 97.1% on a per patient basis and 100%, 85.7% and 98% on per lesion basis, respectively.{sup 131}I MIBG scintigraphy was concordant with {sup 68}Ga-DOTA-NOC PET-CT in 16 patients and false negative in 9 patients. {sup 68}Ga-DOTA-NOC PET-CT is highly sensitive and specific for the detection of phaeochromoctyomas and paragangliomas. It seems better than {sup 131}I MIBG scintigraphy for this purpose. (orig.)

  1. An interview with Dr Diane Austin

    OpenAIRE

    Patricia Preston-Roberts

    2011-01-01

    For many years Dr Diane Austin has been developing a very special use of the voice in her practice as a music psychotherapist. The transformational aspects of this approach have been witnessed by colleagues who have heard Diane present at conferences or have read of her work in various publications. There are now further opportunities for colleagues to find out more about her work by reading her recent book or participating in her trainings. On behalf of the editors of the series of interview...

  2. Preliminary studies of the biosynthesis of Austin

    International Nuclear Information System (INIS)

    Aspergillus ustus is one of the most prevalent fungi in the soil. There are now two reports of the occurrence of toxin-producing strains of this fungus on stored foodstuffs. In addition, strains of A. ustus have been isolated along with Penicillium species from samples of South African cheeses. All A. ustus isolates tested were judged to be highly toxic to ducklings when grown on maize meal, however, the toxins involved were not isolated. Austin is the trivial name of one of the toxins made by the fungus found on stored food. Preliminary work to studying the biosynthesis of this compound using 13C-labeled sodium acetate is reported here. The feasibility of the biosynthetic study was determined by feeding [1-14C]-sodium acetate to A. ustus cultures. The assignments made in the 13C-nmr spectrum of Austin are shown. The lowest dilution factor obtained in [1-14C]-sodium acetate feeding experiments was 14. This dilution factor is sufficiently low to allow a successful feeding of [1,2-13C2]-sodium acetate. A new metabolite of A. ustus, deacetylaustin, was isolated and identified. An alkaloid of unknown structure was also isolated from the fungus

  3. Out of the Ordinary: Incorporating Limits with Austin and Derrida

    Science.gov (United States)

    Williams, Emma

    2014-01-01

    This article seeks to open up a re-examination of the relationship between thought and language by reference to two philosophers: John Austin and Jacques Derrida. While in traditional philosophical terms these thinkers stand far apart, recent work in the philosophy of education has highlighted the importance of Austin's work in a way that has…

  4. 75 FR 9438 - Samsung Austin Semiconductor, LLC, DRAM Fab 1, a Subsidiary of Samsung Electronics Corporation...

    Science.gov (United States)

    2010-03-02

    ... Employment and Training Administration Samsung Austin Semiconductor, LLC, DRAM Fab 1, a Subsidiary of Samsung..., applicable to workers of Samsung Austin Semiconductor, LLC, a subsidiary of Samsung Electronics Corporation... Systems, Inc. were employed on-site at the Austin, Texas location of Samsung Austin Semiconductor, LLC,...

  5. EnviroAtlas - Austin, TX - Ecosystem Services by Block Group

    Data.gov (United States)

    U.S. Environmental Protection Agency — This EnviroAtlas dataset presents environmental benefits of the urban forest in 750 block groups in Austin, Texas. Carbon attributes, temperature reduction,...

  6. An interview with Dr Diane Austin

    Directory of Open Access Journals (Sweden)

    Patricia Preston-Roberts

    2011-03-01

    Full Text Available For many years Dr Diane Austin has been developing a very special use of the voice in her practice as a music psychotherapist. The transformational aspects of this approach have been witnessed by colleagues who have heard Diane present at conferences or have read of her work in various publications. There are now further opportunities for colleagues to find out more about her work by reading her recent book or participating in her trainings. On behalf of the editors of the series of interviews for Voices I am delighted to be able to introduce this interview with Diane by one of her colleagues Patricia Preston-Roberts. There is also a linked audio example. In the interview Diane explains how her approach evolved and she identifies some of the key features of the work. She provides some links to the theories underpinning her practice and talks very openly about some issues of countertransference that arise as part of this very powerful and profound way of working. Throughout the interview we are aware how all aspects of the voice have an enormous influence on the development of a warm and trusting therapeutic relationship. From the moment a client enters Diane's consulting room it is clear that her deep and empathic listening ability enables her to make connections to every vocal nuance, whether spoken or sung. As she points out "the whole session" can be viewed "as an improvisation."

  7. Pet Health

    Science.gov (United States)

    Pets can add fun, companionship and a feeling of safety to your life. Before getting a pet, think carefully about which animal is best for ... is each family member looking for in a pet? Who will take care of it? Does anyone ...

  8. Austin, dehydroaustin and other metabolites from Penicillium brasilianum

    Energy Technology Data Exchange (ETDEWEB)

    Schuermann, Betania T.M. [Universidade Federal de Ouro Preto (EF/UFOP), MG (Brazil). Escola de Farmacia; Sallum, William S.T.; Takahashi, Jacqueline A., E-mail: jat@qui.ufmg.b [Universidade Federal de Minas Gerais (DQ/UFMG), Belo Horizonte (Brazil). Dept. de Quimica

    2010-07-01

    A culture of P. brasilianum, isolated from soil collected at the Serra do Cipo National Park, in Minas Gerais State (Brazil), was grown for 25 days on a dextrose-peptone-salts medium. The corresponding ethylacetate extract was column chromatographed and four compounds were isolated: austin, dehydroaustin, D-mannitol and penicillic acid. This is, in the best of our knowledge, the first time that the meroterpenes austin and dehydroaustin have been isolated from this species. Activity of the extract and isolated compounds was tested against six bacteria and for acetylcholinesterase inhibition. Penicillic acid showed high activity in both tests. (author)

  9. Assessing the effects of recent immigration on serious property crime in Austin, Texas

    OpenAIRE

    Stansfield, R; Akins, S; Rumbaut, RG; Hammer, RB

    2013-01-01

    In this article the authors examine the impact of recent immigration on rates of serious property crime across communities in Austin, Texas. The greater Austin foreign-born population has increased by more than 580 percent since 1980, and Austin is considered a "preemerging" immigrant gateway city to the United States. The changing population dynamics in Austin provide an excellent opportunity to study the effect of recent immigration on crime in a target destination for recent immigrants. Al...

  10. 76 FR 73587 - Foreign-Trade Zone 183-Austin, Tx; Site Renumbering Notice

    Science.gov (United States)

    2011-11-29

    ...)--Ben White Business Park, South Industrial Drive/Business Center Drive, Austin; Site 11 (64.5 acres)--Walnut Business Park, US 290/US 183, Austin; Site 12 (100 acres)--Harris Branch, Harris Branch Parkway/Parmer Lane, Austin; Site 13 (15 acres)-- Hill Partners w/n Global Business Park, Rutherford...

  11. 78 FR 68814 - Subzone 183B; Authorization of Production Activity; Samsung Austin Semiconductor, LLC...

    Science.gov (United States)

    2013-11-15

    ... (78 FR 40427, 7-5-2013). The FTZ Board has determined that no further review of the activity is... Foreign-Trade Zones Board Subzone 183B; Authorization of Production Activity; Samsung Austin Semiconductor, LLC (Semiconductors); Austin, Texas On June 26, 2013, Samsung Austin Semiconductor, LLC submitted...

  12. Making Health Easier: Active Living in Austin, TX PSA (:60)

    Centers for Disease Control (CDC) Podcasts

    2013-06-07

    A local Austin, Texas, woman started a walking group to make physical activity fun for herself and community.  Created: 6/7/2013 by National Center for Chronic Disease Prevention and Health Promotion (NCCDPHP).   Date Released: 6/7/2013.

  13. Supporting and Rewarding Accomplished Teaching: Insights from Austin, Texas

    Science.gov (United States)

    Lussier, David F.; Forgione, Pascal D., Jr.

    2010-01-01

    This article explores the strategic compensation efforts of the Austin Independent School District (AISD) in Texas, which is piloting a system of supports and rewards for teachers and administrators. The article highlights the key components of this system, what it took to put a 4-year pilot program in place, and what results are emerging from…

  14. Diabetic Pets

    Science.gov (United States)

    ... health or management, contact your veterinarian. In addition, diabetic pets should be monitored for long-term complications such as cataracts, which commonly develop in diabetic dogs and cats. Other problems that can occur ...

  15. Senior Pets

    Science.gov (United States)

    ... Future AVMA Meeting Dates Meetings & CE Calendar Symposiums & Summits Pet Health Awareness Events About AVMA Who We ... and small dogs are generally considered “senior” at seven years of age. Larger breed dogs tend to ...

  16. Positron Emission Tomography (PET)

    Science.gov (United States)

    Welch, M. J.

    1990-01-01

    Positron emission tomography (PET) assesses biochemical processes in the living subject, producing images of function rather than form. Using PET, physicians are able to obtain not the anatomical information provided by other medical imaging techniques, but pictures of physiological activity. In metaphoric terms, traditional imaging methods supply a map of the body's roadways, its, anatomy; PET shows the traffic along those paths, its biochemistry. This document discusses the principles of PET, the radiopharmaceuticals in PET, PET research, clinical applications of PET, the cost of PET, training of individuals for PET, the role of the United States Department of Energy in PET, and the futures of PET.

  17. Positron Emission Tomography (PET)

    Energy Technology Data Exchange (ETDEWEB)

    Welch, M.J.

    1990-01-01

    Positron emission tomography (PET) assesses biochemical processes in the living subject, producing images of function rather than form. Using PET, physicians are able to obtain not the anatomical information provided by other medical imaging techniques, but pictures of physiological activity. In metaphoric terms, traditional imaging methods supply a map of the body's roadways, its, anatomy; PET shows the traffic along those paths, its biochemistry. This document discusses the principles of PET, the radiopharmaceuticals in PET, PET research, clinical applications of PET, the cost of PET, training of individuals for PET, the role of the United States Department of Energy in PET, and the futures of PET. 22 figs.

  18. Positron Emission Tomography (PET)

    International Nuclear Information System (INIS)

    Positron emission tomography (PET) assesses biochemical processes in the living subject, producing images of function rather than form. Using PET, physicians are able to obtain not the anatomical information provided by other medical imaging techniques, but pictures of physiological activity. In metaphoric terms, traditional imaging methods supply a map of the body's roadways, its, anatomy; PET shows the traffic along those paths, its biochemistry. This document discusses the principles of PET, the radiopharmaceuticals in PET, PET research, clinical applications of PET, the cost of PET, training of individuals for PET, the role of the United States Department of Energy in PET, and the futures of PET. 22 figs

  19. Austin Children`s Museum ``Go Power`` project. Final report

    Energy Technology Data Exchange (ETDEWEB)

    1993-10-01

    Go Power, was conceived as an interactive exhibit and related set of activities designed to promote in children and families an understanding and appreciation of energy concepts. Planned in 1990, the project culminated its first phase of activities with colorful, interactive exhibit about the pathways and transformations of energy, on display at the Austin Children`s Museum between February 5th and June 6th, 1993. The project was supported by the US Department of Energy, the National Science Foundation, the Lower Colorado River Authority and various local foundations and businesses. This report describes the process, product and outcomes of this project.

  20. Ga-68 DOTANOC PET/CT imaging in detection of primary site in patients with metastatic neuroendocrine tumours of unknown origin and its impact on clinical decision making: experience from a tertiary care centre in India

    Science.gov (United States)

    Pankaj, Promila; Verma, Ritu; Jain, Anjali; Belho, Ethel S.; Mahajan, Harsh

    2016-01-01

    Background Neuroendocrine tumours (NETs) are rare, heterogeneous group of tumours which usually originate from small, occult primary sites and are characterized by over-expression of somatostatin receptors (SSTRs). Positron emission tomography/computed tomography (PET/CT) using Ga-68-labeled-somatostatin-analogues have shown superiority over other modalities for imaging of NETs. The objective of the study was to retrospectively evaluate the efficacy of Ga-68 DOTANOC PET/CT imaging in detecting the primary site in patients with metastatic NETs of unknown origin and its impact on clinical decision making in such patients. Methods Between December 2011 and September 2014, a total of 263 patients underwent Ga-68 DOTANOC PET/CT study in our department for various indications. Out of them, 68 patients (45 males, 23 females; mean age, 54.9±10.7 years; range, 31–78 years) with histopathologically proven metastatic NETs and unknown primary site (CUP-NET) on conventional imaging, who underwent Ga-68 DOTANOC PET/CT scan as part of their clinical work-up were included for analyses. Histopathology (wherever available) and/or follow-up imaging were taken as reference standard. Quantitative estimation of SSTR expression in the form of maximal standardized uptake value (SUVmax) of detected primary and metastatic sites was calculated. Follow-up data of individual patients was collected through careful survey of hospital medical records and telephonic interviews. Results Maximum patients presented to our department with hepatic metastasis (50 out of 68 patients) and grade I NETs (>50%). Ga-68 DOTANOC PET/CT scan identified primary sites in 40 out of these 68 patients i.e., in approximately 59% patients. Identified primary sites were: small intestine [19], rectum [8], pancreas [7], stomach [4], lung [1] and one each in rare sites in kidney and prostate. In one patient, 2 primary sites were identified (one each in stomach and duodenum). Mean SUVmax of the detected primary sites was

  1. Horizontal spacing, depletion, and infill potential in the Austin chalk

    Energy Technology Data Exchange (ETDEWEB)

    Kyte, D.G.; Meehan, D.N.

    1996-12-31

    Estimated ultimate recoveries on a barrels per acre basis for Austin chalk wells were discussed. The study showed that the maximum six months consecutive production through the life of the well can be used to estimate ultimate recovery in horizontally drilled reservoirs. A statistical approach was used to help identify where the Austin chalk has been overdrilled and areas where infill potential exists. The barrels per acre data were analyzed by a method known as `moving domain`. This procedure involves stepping through the reservoir well by well and looking at it with respect to its nearest neighbors. To analyze for depletion, barrels per acre is compared to date of first production for groups of wells in an area, looking for declining values with time. Areas showing no evidence of depletion and having good recoveries are further studied for infill potential. By comparing effective densities in areas which are not yet being fully drained, an optimum spacing between wells can be determined for horizontal wells in a fractured chalk reservoir. An artificial neural network can also be used to provide qualitative predictions of well performance in developed reservoirs. 6 refs., 15 figs.

  2. TRIGA reactor relocation at the University of Texas at Austin

    International Nuclear Information System (INIS)

    The University of Texas at Austin (UT) is in the process of relocating its TRIGA reactor facilities. This undertaking includes the construction of a new reactor building with laboratories and offices and the decommissioning of the existing facility. The main campus of The University of Texas at Austin is becoming congested, and several major research projects (mostly engineering) are moving to the Balcones Research Center ∼ 8 miles from the main campus. The process of constructing a new nuclear facility in today's regulatory environment can best be described as challenging. Fortunately, research reactor licensing is not as complicated as that for commercial power facilities, although many procedures are similar. Unfortunately, the university has its own challenging procedures for building construction. Considerable time has been expended coordinating the US Nuclear Regulatory Commission (NRC) and UT licensing and construction activities. The paper summarizes the major steps and dates accomplished. The new reactor facility at the Balcones Research Center will enhance the universities ability to carry on teaching and research activities. The increased power level and the Mark II arrangement will allow us to perform new and additional projects. Considerable time and effort were devoted by the Nuclear Engineering Laboratory staff to ensure that the facility would provide educational and research flexibility over the next several years

  3. Preliminary studies of the biosynthesis of Austin. [Aspergillus ustus

    Energy Technology Data Exchange (ETDEWEB)

    Wicnienski, N.A.

    1979-01-01

    Aspergillus ustus is one of the most prevalent fungi in the soil. There are now two reports of the occurrence of toxin-producing strains of this fungus on stored foodstuffs. In addition, strains of A. ustus have been isolated along with Penicillium species from samples of South African cheeses. All A. ustus isolates tested were judged to be highly toxic to ducklings when grown on maize meal, however, the toxins involved were not isolated. Austin is the trivial name of one of the toxins made by the fungus found on stored food. Preliminary work to studying the biosynthesis of this compound using /sup 13/C-labeled sodium acetate is reported here. The feasibility of the biosynthetic study was determined by feeding (1-/sup 14/C)-sodium acetate to A. ustus cultures. The assignments made in the /sup 13/C-nmr spectrum of Austin are shown. The lowest dilution factor obtained in (1-/sup 14/C)-sodium acetate feeding experiments was 14. This dilution factor is sufficiently low to allow a successful feeding of (1,2-/sup 13/C/sub 2/)-sodium acetate. A new metabolite of A. ustus, deacetylaustin, was isolated and identified. An alkaloid of unknown structure was also isolated from the fungus.

  4. Pet Therapy.

    Science.gov (United States)

    Kavanagh, Kim

    1994-01-01

    This resource guide presents information on a variety of ways that animals can be used as a therapeutic modality with people having disabilities. Aspects addressed include: pet ownership and selection criteria; dogs (including service dogs, hearing/signal dogs, seeing leader dogs, and social/specialty dogs); horseriding for both therapy and fun;…

  5. 78 FR 40427 - Foreign-Trade Zone (FTZ) 183-Austin, Texas; Notification of Proposed Production Activity; Samsung...

    Science.gov (United States)

    2013-07-05

    ... Activity; Samsung Austin Semiconductor, LLC (Semiconductors); Austin, Texas Samsung Austin Semiconductor, LLC (Samsung), operator of Subzone 183B, submitted a notification of proposed production activity to... the regulations of the FTZ Board (15 CFR 400.22) was received on June 26, 2013. Samsung currently...

  6. Pet Allergy Quiz

    Science.gov (United States)

    ... people with pet allergy do better with a dog that has short hair or sheds less. Question 2 Pet allergies are triggered by the hair on a pet. True False False: Pet allergies are caused by an allergen found on the pet’s skin (dander), saliva or urine. Question 3 Symptoms of pet allergy ...

  7. American Pet Culture

    Institute of Scientific and Technical Information of China (English)

    海焰

    2007-01-01

    In America you can find dogs,cats, horses,monkeys, snakes and even pigs in almost every family.They are their pets.Americans love pets and look on them as a part of the family.Sometimes pet owners dress their pets in fashionable clothes.They even buy toys for their pets.Americans love their pets as their children, sometimes even better.

  8. Pet Problems at Home: Pet Problems in the Community.

    Science.gov (United States)

    Soltow, Willow

    1984-01-01

    Discusses problems of pets in the community, examining the community's role related to disruptive pets and pet overpopulation. Also discusses pet problems at home, offering advice on selecting a pet, meeting a pet's needs, and disciplining pets. Includes a list of books, films/filmstrips, teaching materials, and various instructional strategies.…

  9. A Study on Pet Owners' Intention to Purchase Pet Insurance

    OpenAIRE

    Chiehwei Hung; Yen-Shan Chuang

    2014-01-01

    This study investigates the impacts of consumers¡¦ characteristics, pet feeding habits, pet spending and insurance conditions of pet owners on the intention to purchase a pet insurance policy. Our results reveal that family income, average monthly spending on pets, and experience of purchasing medical insurance are the significant determinants of a pet owner¡¦s intention to purchase pet insurance. Pet owners who have higher family income, higher pet spending, and who have previously purchased...

  10. EnviroAtlas - Austin, TX - BenMAP Results by Block Group

    Data.gov (United States)

    U.S. Environmental Protection Agency — This EnviroAtlas dataset demonstrates the effect of changes in pollution concentration on local populations in 750 block groups in Austin, Texas. The US EPA's...

  11. EnviroAtlas -- Austin, TX -- One Meter Resolution Urban Land Cover Data (2010)

    Data.gov (United States)

    U.S. Environmental Protection Agency — The Austin, TX EnviroAtlas One Meter-scale Urban Land Cover (MULC) Data were generated from United States Department of Agriculture (USDA) National Agricultural...

  12. EnviroAtlas -- Austin, TX -- One Meter Resolution Urban Land Cover Data (2010) Web Service

    Data.gov (United States)

    U.S. Environmental Protection Agency — This EnviroAtlas web service supports research and online mapping activities related to EnviroAtlas (https://www.epa.gov/enviroatlas ). The Austin, TX EnviroAtlas...

  13. Positron research at the University of Texas at Austin

    Science.gov (United States)

    Goktepeli, Sinan

    The objective of the research presented in this dissertation is to advance the applications of positron annihilation research. An intense positron beam facility was designed and constructed, and a method was developed to better analyze the defect structure of solids. The Texas Reactor-based Intense Positron beam facility (TRIP) was designed to provide a monoenergetic/monodirectional beam of at least 108 e +/sec on a sample. This increase in beam intensity will enhance many positron research techniques both in atomic physics and materials science. The TRIP facility, the result of a collaboration between UT Austin and UT Arlington, is being developed around the concept of multiple scattering of positrons from solid krypton. A large area copper source will be irradiated in a beam port of the 1 MW TRIGA Mark-II research reactor at UT Austin. The source will form the bottom face of a cube with the remaining faces made of tungsten. All surfaces will be cooled down to 22 K and coated with krypton. The top face of the cube has a 1 cm diameter hole to allow for the passage of positrons. The fast beta particles emitted from the β+ decay of 64Cu will be moderated while passing through the krypton. The non- moderated positrons will lose their energy while interacting with the remaining walls. The positrons will be removed from the box by an electric field and electrostatically delivered to the sample. The work on the TRIP facility is ongoing. The results of early measurements at UT Arlington have shown that the facility will be able to achieve its goals. The method developed to better analyze the positron depth profiling (PDP) experiments uses the difference spectra of the measured Doppler broadened annihilation peaks. The difference spectra, which are obtained by subtracting the bulk peak shape from the peaks recorded for each incident positron energy, enhance the differences of the observed peaks, while removing the bulk annihilation term from the multi-state annihilation

  14. PET studies of stroke

    International Nuclear Information System (INIS)

    PET already has been helpful in ischemic stroke disease. It has given us new data on physiological events occurring after a stroke; PET indices of blood flow and metabolism have provided the basis for staging the severity of tissue injury and predicting outcome, and PET has shown alterations in tissue function in response to therapy. Experience with PET in hemorrhagic disease is more limited, but initial results suggest a useful role for PET in the evaluation of nontraumatic intracranial hemorrhage as well [Ackerman et al., 1983a]. This brief review discusses general problems in the study of stroke disease using PET and then the contribution of PET to the stroke field

  15. CyberPET: a PET service distributed over a wide area

    International Nuclear Information System (INIS)

    Aim: Demonstration of bi-directional PET data transmission, interactive display and co-registration, for the purpose of correlative imaging, treatment planning and teaching. Material and Method: In the year 2000, the initial problem to attend was to provide an effective PET service to a hospital (in Luxemburg) which lies 150 km away from a PET center (in another country). Once this solved, the procedure was expanded (in 2001) to co-registration with CT/MRI scans performed locally, and with radiotherapy simulation CT performed in another center 25 km away (in 2002). Equipment from various vendors was used (Siemens, Adac, GE, Hermes). With preliminary agreement of the national medical aid, patients are sent from the Nuclear Medicine Dept of the Centre Hospitalier in Luxemburg (CHL) to the Dept NM of the Saarland University Medical Center for PET examination. The digital data are then sent from the Siemens PET camera to a PC connected to the LAN, and then to a FTP server (Healthnet). The data are similarly collected by a PC of the hospital network in Luxemburg, and transferred to a Hermes NM station. The Dicom PET data are converted on the fly to Interfile, displayed interactively as any other tomographic data, printed and available on the NM image server. Since 2001, the PET data are co-registered with whole-body CT data recorded at CHL according to a specific protocol (see other paper of this group). Now in 2002, we are busy implementing the co-registration of PET data and simulation CT data obtained from the Centre Baclesse (CFB, 25 km from CHL) for the treatment planning of brain tumours (input into an ADAC system). Furthermore, we plan to send the data (after deletion of their digital ID) to a (South African) university which does not yet dispose of a PET camera, to allow the training of their registrars. Results: For the end-user clinician at CHL and CFB , the PET data have the quality of 'live data', which can be examined interactively, along with other imaging

  16. Heart PET scan

    Science.gov (United States)

    ... nuclear medicine scan; Heart positron emission tomography; Myocardial PET scan ... A PET scan requires a small amount of radioactive material (tracer). This tracer is given through a vein (IV), ...

  17. Clinical PET application

    Energy Technology Data Exchange (ETDEWEB)

    Lim, Sang-Moo; Hong, S. W.; Choi, C. W.; Yang, S. D.; Choi, J. S.; Kweon, O. J. et al. [Korea Cancer Center Hospital, Seoul (Korea)

    2000-12-01

    PET gives various metabolic images, and is very important, new diagnostic modality in clinical oncology. In Korea Cancer Center Hospital, PET is installed as a research tool of long-mid-term atomic research project. For the efficient use of PET for clinical and research projects, income from the patients should be managed to get the raw material, equipment, manpower, and also for the clinical PET research. 1. Support the clinical application of PET in oncology. 2. Budgetary management of income, costs for raw material, equipment, manpower, and the clinical PET research project. In this year, 1,327 cases of PET images were obtained, which resulted total income of 829,770,000won. Increased demand for {sup 18}FDG in and outside KCCH need more than 2 times production of {sup 18} in a day. Manpower should be added for the second PET operation and RI production. 10 figs., 4 tabs. (Author)

  18. Overview of the software architecture and data flow for the J-PET tomography device

    CERN Document Server

    Krzemień, W; Białas, P; Czerwiński, E; Gajos, A; Głowacz, B; Jasińska, B; Kamińska, D; Korcyl, G; Kowalski, P; Kozik, T; Kubicz, E; Niedźwiecki, Sz; Pawlik-Niedźwiecka, M; Raczyński, L; Rudy, Z; Silarski, M; Strzelecki, A; Wieczorek, A; Wiślicki, W; Zieliński, M; Moskal, P

    2016-01-01

    Modern TOF-PET scanner systems require high-speed computing resources for efficient data processing, monitoring and image reconstruction. In this article we present the data flow and software architecture for the novel TOF-PET scanner developed by the J-PET collaboration. We discuss the data acquisition system, reconstruction framework and image reconstruction software. Also, the concept of computing outside hospitals in the remote centers such as \\'Swierk Computing Centre in Poland is presented.

  19. Overview of the software architecture and data flow for the J-PET tomography device

    CERN Document Server

    Krzemien, W; Bialas, P; Czerwinski, E; Gajos, A; Gruntowski, A; Gruntowski, T; Kaplon, L; Kochanowski, A; Korcyl, G; Kowal, J; Kowalski, P; Kozik, T; Kubicz, E; Moskal, P; Niedzwiecki, Sz; Palka, M; Raczynski, L; Rudy, Z; Sharma, N G; Silarski, M; Slomski, A; Stola, K; Strzelecki, A; Trybek, D; Wieczorek, A; Zielinski, M; Wislicki, W; Zon, N

    2015-01-01

    Modern TOF-PET scanner systems require high-speed computing resources for efficient data processing, monitoring and image reconstruction. In this article we present the data flow and software architecture for the novel TOF-PET scanner developed by the J-PET collaboration. We discuss the data acquisition system, reconstruction framework and some image reconstruction issues. Also, the concept of computing outside hospitals in the remote centers such as \\'Swierk Computing Centre in Poland is presented.

  20. CMS Centre at CERN

    CERN Multimedia

    2007-01-01

    A new "CMS Centre" is being established on the CERN Meyrin site by the CMS collaboration. It will be a focal point for communications, where physicists will work together on data quality monitoring, detector calibration, offline analysis of physics events, and CMS computing operations. Construction of the CMS Centre begins in the historic Proton Synchrotron (PS) control room. The historic Proton Synchrotron (PS) control room, Opened by Niels Bohr in 1960, will be reused by CMS to built its control centre. TThe LHC@FNAL Centre, in operation at Fermilab in the US, will work very closely with the CMS Centre, as well as the CERN Control Centre. (Photo Fermilab)The historic Proton Synchrotron (PS) control room is about to start a new life. Opened by Niels Bohr in 1960, the room will be reused by CMS to built its control centre. When finished, it will resemble the CERN Contro...

  1. Solar heating and cooling demonstration project at Radian Corporation, Austin, Texas

    Science.gov (United States)

    1980-01-01

    The solar heating and cooling system located at the Radian Corporation, Austin, Texas, is discussed. A technical description of the solar system is presented. The costs of the major components and the cost of installing the system are described. Flow diagrams and photographs of the solar system are provided.

  2. Austin Community College Employee Satisfaction Survey, Spring 2000: Results and Analysis.

    Science.gov (United States)

    Oburn, Martha L.

    Austin Community College mailed an Employee Satisfaction Survey in spring 2000 to 2,903 employees. The survey form asked respondents to rate college-wide and/or campus services that they had requested or received during the past year in terms of promptness, quality, attitude and overall service. The overall survey return rate was 15.4%, but rates…

  3. Austin Youth River Watch Program: 1992-93 Final Report. Publication Number 92.33.

    Science.gov (United States)

    Turner, Jeannine

    The City of Austin (Texas) provides funds for an educational initiative to involve minority high school students in water quality issues and to reduce the dropout rate through positive role model interaction with academically successful students. Principal program activities were testing river water for pollutants and tutoring at-risk students by…

  4. 76 FR 77245 - Attwater Prairie Chicken National Wildlife Refuge, Austin and Colorado Counties, TX...

    Science.gov (United States)

    2011-12-12

    ... process through a notice in the Federal Register (73 FR 65871; November 5, 2008). The Attwater Prairie... conservation plan and environmental assessment (EA) in the Federal Register on November 5, 2008 (73 FR 65871... Fish and Wildlife Service Attwater Prairie Chicken National Wildlife Refuge, Austin and...

  5. 78 FR 51327 - Endangered and Threatened Wildlife and Plants; Designation of Critical Habitat for the Austin...

    Science.gov (United States)

    2013-08-20

    ... cover with no water quality controls is considered to contain features essential for the conservation of... Travis and Williamson Counties, Texas, fall within the boundaries of the critical habitat designation....regulations.gov and http://www.fws.gov/southwest/es/AustinTexas/ at Docket No. FWS-R2-ES-2013-0001....

  6. Dow Water Solutions launches partnership with Virginia Tech, University of Texas at Austin

    OpenAIRE

    Trulove, Susan

    2008-01-01

    Dow Water Solutions, a business unit of The Dow Chemical Company (Dow) and global leader in water purification, seawater desalination, contamination removal and water reuse solutions, has reached a multi-year joint development partnership with Virginia Tech and the University of Texas at Austin on the research and development of oxidation-resistant reverse osmosis (RO) membranes.

  7. 76 FR 12788 - Environmental Impact Statement for a Proposed Urban Rail system in Austin, TX

    Science.gov (United States)

    2011-03-08

    ... Federal Transit Administration Environmental Impact Statement for a Proposed Urban Rail system in Austin, TX AGENCY: Federal Transit Administration, DOT. ACTION: Notice of Intent to Prepare an Environmental... system. The No-Build Alternative serves as the NEPA baseline against which the environmental effects...

  8. Equal Partners. Austin Teenagers Learn To Expect Respect in Dating Relationships.

    Science.gov (United States)

    Harrison, Mary M.

    1997-01-01

    Describes the Teen Dating Violence Project, a 24-week program in the Austin (Texas) schools that offers single sex support groups for young men and women involved in violent relationships. Learning to build equitable and respectful relationships often involves unlearning gender stereotypes, but the program shows that attitudes can change. (SLD)

  9. Effective-stress-law behavior of Austin chalk rocks for deformation and fracture conductivity

    Energy Technology Data Exchange (ETDEWEB)

    Warpinski, N.R.; Teufel, L.W.

    1994-08-01

    Austin chalk core has been tested to determine the effective law for deformation of the matrix material and the stress-sensitive conductivity of the natural fractures. For deformation behavior, two samples provided data on the variations of the poroelastic parameter, {alpha}, for Austin chalk, giving values around 0.4. The effective-stress-law behavior of a Saratoga limestone sample was also measured for the purpose of obtaining a comparison with a somewhat more porous carbonate rock. {alpha} for this rock was found to be near 0.9. The low {alpha} for the Austin chalk suggests that stresses in the reservoir, or around the wellbore, will not change much with changes in pore pressure, as the contribution of the fluid pressure is small. Three natural fractures from the Austin chalk were tested, but two of the fractures were very tight and probably do not contribute much to production. The third sample was highly conductive and showed some stress sensitivity with a factor of three reduction in conductivity over a net stress increase of 3000 psi. Natural fractures also showed a propensity for permanent damage when net stressed exceeded about 3000 psi. This damage was irreversible and significantly affected conductivity. {alpha} was difficult to determine and most tests were inconclusive, although the results from one sample suggested that {alpha} was near unity.

  10. Austin Community College Management Response to Employee Satisfaction Survey, Spring 2000.

    Science.gov (United States)

    Austin Community Coll., TX.

    Findings from an Employee Satisfaction Survey conducted in spring 2000 at Austin Community College (ACC) (Texas) indicate that: (1) staff in many areas need customer service training; (2) telephones are not used effectively by many offices; (3) many areas are not able to respond quickly to the needs of college staff; and (4) 18 highly used areas…

  11. Ein Überblick über die Sprechakttheorie von Austin und Searle

    Institute of Scientific and Technical Information of China (English)

    周婧

    2016-01-01

    Die Sprechakttheorie ist ein bedeutender Teilbereich von der linguistischen Pragmatik, die sich seit den 50er und 60er Jahren des letzten Jahrhunderts entwickelte. Die berühmten Sprachwissenschaftler Austin und Searle legten den Grundstein zu Sprechakttheorie. Dieser Text liefert einen Überblick ü ber die Forschungsergebnisse von den beiden Forschern. Dadurch kann man die Entwicklung der Sprechakttheorie gut erkennen.

  12. Salmonella: Dry Pet Foods and Pet Treats (FAQ)

    Science.gov (United States)

    ... Guides Reports Salmonella: Dry Pet Foods and Pet Treats (FAQ) Originally posted August 9, 2010; Updated August ... as a result of the outbreak. “Natural” pet treats , such as pig ears and dehydrated/dried beef ...

  13. Clinical PET application

    Energy Technology Data Exchange (ETDEWEB)

    Lim, Sang Moo; Hong, Song W.; Choi, Chang W.; Yang, Seong Dae [Korea Cancer Center Hospital, Seoul (Korea)

    1997-12-01

    PET gives various methabolic images, and is very important, new diagnostic modality in clinical oncology. In Korea Cancer Center Hospital, PET is installed as a research tool of long-mid-term atomic research project. For the efficient use of PET for clinical and research projects, income from the patients should be managed to get the raw material, equipment, manpower, and also for the clinical PET research. 1. Support the clinical application of PET in oncology. 2. Budgetary management of income, costs for raw material, equipment, manpower, and the clinical PET research project. In this year, 250 cases of PET images were obtained, which resulted total income of 180,000,000 won. 50,000,000 won was deposited for the 1998 PET clinical research. Second year PET clinical research should be managed under unified project. Increased demand for {sup 18}FDG in and outside KCCH need more than 2 times production of {sup 18}FDG in a day purchase of HPLC pump and {sup 68}Ga pin source which was delayed due to economic crisis, should be done early in 1998. (author). 2 figs., 3 tabs.

  14. PET imaging in patients with Modic changes

    Energy Technology Data Exchange (ETDEWEB)

    Albert, H.B.; Manniche, C. [Univ. of Southern Denmark, Funen (Denmark). Back Research Centre; Petersen, H.; Hoeilund-Carlsen, P.F. [Odense University Hospital, Univ. of Southern Denmark (Denmark). Dept. of Nuclear Medicine

    2009-07-01

    The aim of this study was via PET imaging to reveal if any highly metabolic processes were occurring in Modic changes type 1 and/or in the adjacent discs. Modic changes (MC) are signal changes in the vertebral endplate and body visualised by magnetic resonance imaging (MRI). MC are strongly associated with low back pain (LBP). MC type 1 appear to be inflammation on MRI, and histological and biochemical findings make it highly likely that an inflammation is present. Though MC is painful no known treatment is available, and it is unknown which entities affect the progress or regress of MC. The changes observed on MRI are slow and take months to develop, but faster changes in the metabolism might provide a platform for monitoring patients. Patients from The Back Centre Funen, with low back pain in the area of L1 to S1, MC type 1 in L1 to L5, and a previous herniated lumbar disc. All patients had a PET scan using FDG ({sup 18}F-fluorodeoxyglucose) as tracer. Included in the study were 11 patients, 4 women and 7 men, mean age 48.1 year (range 20-65). All MC were situated in the vertebrae both above and below the previously herniated disc/discs. Ten patients had MC at 1 level, and 1 had MC at 2 levels. The affected levels were 1 at L2/L3, 6 at L4 /L5, and 5 at L5/S1. All had a previous disc herniation and MC larger than 4 mm in diameter. Technically satisfactory PET scans were obtained. However, PET imaging showed no increases in metabolism in any vertebra or disc of any patient. Modic type 1 changes do not reveal themselves by showing increased metabolism with ordinary FDG PET imaging. PET tracers illuminating inflammation are being developed and hopefully may become more successful. (orig.)

  15. Client Centred Desing

    DEFF Research Database (Denmark)

    Ørngreen, Rikke; Nielsen, Janni; Levinsen, Karin

    2008-01-01

    In this paper we argue for the use of Client Centred preparation phases when designing complex systems. Through Client Centred Design human computer interaction can extend the focus on end-users to alse encompass the client's needs, context and resources.......In this paper we argue for the use of Client Centred preparation phases when designing complex systems. Through Client Centred Design human computer interaction can extend the focus on end-users to alse encompass the client's needs, context and resources....

  16. Canadian Irradiation Centre

    International Nuclear Information System (INIS)

    The Canadian Irradiation Centre is a non-profit cooperative project between Atomic Energy of Canada Limited, Radiochemical Company and Universite du Quebec, Institut Armand-Frappier, Centre for Applied Research in Food Science. The Centre's objectives are to develop, demonstrate and promote Canada's radiation processing technology and its applications by conducting applied research; training technical, professional and scientific personnel; educating industry and government; demonstrating operational and scientific procedures; developing processing procedures and standards, and performing product and market acceptance trials. This pamphlet outlines the history of radoation technology and the services offered by the Canadian Irradiation Centre

  17. Rapid evaluation of the cost-effectiveness o FDG-PET in recurrent colorectal cancer

    International Nuclear Information System (INIS)

    Full text: To evaluate the cost-effectiveness of FDG-PET in recurrent colorectal cancer using Australian data whilst avoiding the time delays, costs and ethical difficulties associated with intensive patient follow-up. A decision tree sensitivity analysis was used. The study population comprised patients with recurrent colorectal under consideration for resection of apparently isolated hepatic metastasis in whom demonstration of extra-hepatic tumour would preclude surgery.The results of FDG-PET in a consecutive series of 75 such patients referred to the Wesley PET centre were used to determine the range of possible values for disease prevalence and specificity, assuming the value for PET sensitivity as reported in the federal government's PET review. These values, along with the diagnostic accuracy of CT and Australian costs for procedures (PET = $1200), were entered into decision trees modelling a diagnostic strategy comprising CT only and an alternative strategy where patients without extrahepatic tumour on CT also undergo FDG-PET. The cost per patient, accuracy and Incremental Cost-Accuracy Ratio (ICAR) were determined for each strategy. The PET strategy is cheaper for all possible values of disease prevalence and PET specificity ($306-328 / patient) and is more cost-effective for values of disease prevalence above 0.18 or PET specificity above 0.86. At a typical disease prevalence of 0.3 (PET specificity 0.92), the ICAR for the PET strategy is $9700 versus $11,200 for CT. PET remains cost saving even if the best reported values for sensitivity of CT and worse values for PET are used. FDG-PET for recurrent colorectal cancer in Australia would be cost saving and most probably cost-effective. Copyright (2002) Blackwell Science Pty Ltd

  18. My Pet Rock

    Science.gov (United States)

    Lark, Adam; Kramp, Robyne; Nurnberger-Haag, Julie

    2008-01-01

    Many teachers and students have experienced the classic pet rock experiment in conjunction with a geology unit. A teacher has students bring in a "pet" rock found outside of school, and the students run geologic tests on the rock. The tests include determining relative hardness using Mohs scale, checking for magnetization, and assessing luster.…

  19. Usage of Recycled Pet

    Directory of Open Access Journals (Sweden)

    A. Ebru Tayyar

    2010-01-01

    Full Text Available The increasing industrialization, urbanization and the technological development have caused to increase depletion of the natural resources and environmental pollution's problem. Especially, for the countries which have not enough space recycling of the waste eliminating waste on regular basis or decreasing the amount and volume of waste have provided the important advantages. There are lots of studies and projects to develop both protect resources and prevent environmental pollution. PET bottles are commonly used in beverage industry and can be reused after physical and chemical recycling processes. Usage areas of recycled PET have been developed rapidly. Although recycled PET is used in plastic industry, composite industry also provides usage alternatives of recycled PET. Textile is a suitable sector for recycling of some plastics made of polymers too. In this study, the recycling technologies and applications of waste PET bottles have been investigated and scientific works in this area have been summarized.

  20. PET/CT may change diagnosis and treatment in cancer patients

    DEFF Research Database (Denmark)

    Petersen, Henrik; Nielsen, Mie Jung; Høilund-Carlsen, Mette;

    2010-01-01

    diagnosis in 16% and induced a change in staging and treatment plan in 28% to 32% of cases, respectively. CONCLUSION: FDG PET/CT was mainly used for diagnosis in lung cancer and in cases with an unknown primary tumour, and for response evaluation in lymphomas and colorectal cancer. PET/CT caused a change......INTRODUCTION: The national focus on cancer has propelled the use of PET/CT for cancer imaging in Denmark. We believe that first-year experiences from a large PET centre may be of interest to new users. MATERIAL AND METHODS: Data from all scans made in the period from February 28 2006 to March 1...... 2007 with a single PET/CT scanner and 18F-fluoro-deoxyglucose (FDG) were collected prospectively along with information on action diagnosis, study purpose, etc. Referring departments indicated if PET/CT had changed or confirmed diagnosis, staging and treatment plan. RESULTS: A total of 970 scans were...

  1. PET and PET/CT for imaging of prostate cancer

    International Nuclear Information System (INIS)

    This review article provides an overview of the current literature data regarding the value of PET and PET/CT for imaging of prostate cancer. Most widely used PET tracers for prostate cancer imaging are 11C-acetate and 11C- or 18F-labeled choline. Available literature data on the performance of PET and PET/CT in the detection of the primary malignancy as well as local or distant metastases are presented and discussed. In addition, our own preliminary results regarding the diagnostic efficacy of 11C-choline PET and PET/CT in 43 patients with suspected prostate cancer are provided. The prevalence of prostate cancer in this patient sample was 55.8%. PET and PET/CT showed a sensitivity of 88% with a specificity of 63% in the detection of the primary prostate cancer. The sensitivity in the detection of metastatic spread was 77% and no false-positives were found. The possible value and limitations of combined PET/CT systems when compared to stand alone PET scanners are discussed. PET and PET/CT is at present the single imaging modality providing functional information not only regarding the primary malignancy but also its metastases. This unique feature distinguishes PET from MRI complemented with magnetic resonance spectroscopy - a competing procedure. Our own results as well as the still limited literature data suggest, that PET and PET/CT may prove to be useful methods for imaging of prostate cancer. (orig.)

  2. Archive of Geosample Data and Information from the University of Texas at Austin (UT) Institute of Geophysics

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Metadata describing piston cores curated by Institute of Geophysics of the University of Texas at Austin (UT) collected from 1976 to 1978 were coded and contributed...

  3. Managing change in health care institutions. The Austin experience 1973-1983.

    Science.gov (United States)

    Price, I

    1984-01-01

    This article is written by Ian Price who was engaged as a consultant by the Austin Hospital in 1973 to conduct an organisation study. The result of his work was to establish a divisional organisation which integrated the University of Melbourne into the hospital management structure. His work set in train an extensive organisational development program which has become widely known and regarded in the hospital field. After an absence of nine years Ian Price has taken up an appointment with the Austin an Executive Assistant to the General Manager. This article summarises the process which he adopted and the rationale for the changes which were implemented. The article also presents a brief resume of these changes ten years on. PMID:10270910

  4. H2O(+) production rates of Comets Austin 1990 V and P/Halley 1986 III

    Science.gov (United States)

    Schultz, D.; Scherb, F.; Roesler, F. L.

    1993-01-01

    High-spectral-resolution scans of H2O(+) emissions from Austin 1990 V were obtained. A simple model of the ion distribution in the FOV is used to determine a lower limit phi(H2O+) to the H2O(+) ion flux away from the nucleus for each night of observations. A similar analysis is applied to previous observations of H2O(+) emissions from Comet P/Halley 1986 III. It is found that the mean ratio is phi(H2O+)/Q(H2O) is 1.2 x exp -3 for Halley (solar minimum) and 2.6 x 10 exp -3 for Austin (solar maximum).

  5. The milk of human kindness: the story of the Mothers Milk Bank at Austin

    Directory of Open Access Journals (Sweden)

    Wilson-Clay Barbara

    2006-03-01

    Full Text Available Abstract Increased scientific study of human milk and awareness of the special nutritional needs of the premature infant have stimulated interest in human donor milk banking. Yet only three donor human milk banks existed in the United States in 1998. Having observed better outcomes in human milk-fed neonatal intensive care patients, two neonatologists in Austin, Texas, founded The Mothers Milk Bank at Austin (MMBA. Since opening in 1999, the MMBA has expanded rapidly as the result of careful planning, innovative procedures, fiscal stability, and widespread community support. The non-profit organizational structure, diversity and progressive vision of the board of directors and staff, and creative on-going public relations efforts have contributed to the success of the project. The MMBA demonstrates a model for 21st century milk banking.

  6. Managing change in health care institutions. The Austin experience 1973-1983.

    Science.gov (United States)

    Price, I

    1984-01-01

    This article is written by Ian Price who was engaged as a consultant by the Austin Hospital in 1973 to conduct an organisation study. The result of his work was to establish a divisional organisation which integrated the University of Melbourne into the hospital management structure. His work set in train an extensive organisational development program which has become widely known and regarded in the hospital field. After an absence of nine years Ian Price has taken up an appointment with the Austin an Executive Assistant to the General Manager. This article summarises the process which he adopted and the rationale for the changes which were implemented. The article also presents a brief resume of these changes ten years on.

  7. Personal, Social, and Environmental Correlates of Walking to School Behaviors: Case Study in Austin, Texas

    OpenAIRE

    Xuemei Zhu; Arch, B; Chanam Lee

    2008-01-01

    Walking is an affordable and environmentally clean mode of transportation that can bring additional benefits as healthy physical activity. This cross-sectional study examines the prevalence and correlates of walking to or from school in eight elementary schools in Austin, Texas, which have high percentages of low-income, Hispanic students. A survey of 1,281 parents was conducted, including questions about personal, social, and environmental factors that may influence their decisions on the ch...

  8. Austin y searle: la relación entre verbos y actos ilocucionarios

    Directory of Open Access Journals (Sweden)

    Marco Antonio Alarcón S

    2008-01-01

    Full Text Available El presente artículo intenta dar cuenta de la relación entre los actos de habla y la semántica a partir de los criterios utilizados por Austin y Searle en la elaboración desús respectivas taxonomías de actos ilocucionarios. Para esto, se rastrean bibliográficamentealgunos de los conceptos que utiliza Austin en sus conferencias de Harvard de 1955 (Austin, 1996 con la pretensión de intentar desambiguar en parte los criterios utilizados en la elaboración de sus categorías de verbos ilocucionarios. Luego, se revisan algunos conceptos de Searle y su taxonomía de actos ilocucionarios descritos en "Actos de Habla" (Searle, 1994; y desarrollados en "Una taxonomía de los actos ilocucionarios"(Searle, 1991 b. Finalmente, a partir de la revisión de las clasificaciones y la discusión de la idea de significado que sustenta cada autor se obtiene que el significado de los verbos no depende solamente de su constitución léxica dada, sino que además se potencia en la interacción o uso de una expresión en una emisión real, en que se constituye como acto ilocucionario.IThe present article reviews thecriteria used by Austin and Searleon elabora-ting their respective taxonomies of illocutionary acts to account for the way in which speech acts and semantics relate both authors. In addition, some concepts of Searle and his taxonomy described in "Speech Acts" (1994 and developed in "A taxonomyof Illocutionary acts" (1991 are reviewed.Finally, the idea of meaning sustained by each author is discussed.

  9. John Langshaw Austin e a Visão Performativa da Linguagem

    Directory of Open Access Journals (Sweden)

    OTTONI Paulo

    2002-01-01

    Full Text Available Austin surge no cenário da discussão sobre a linguagem num momento histórico preciso e será o porta-voz de todo um processo histórico da filosofia contemporânea ao revolucionar não só a filosofia analítica naquele momento, como também a lingüística enquanto ciência autônoma. Neste artigo, questiono o caminho e a supremacia do positivismo lógico nos estudos da linguagem, procurando analisar qual é o papel de Austin, neste processo, através da discussão dos conceitos de performativo, de ato de fala, de uptake e de ilocucionário que estão vinculados na sua obra de modo muito especial. Parto da hipótese de que Austin é um "desconstrutor". Denomino sua abordagem da linguagem de "visão performativa", pelo fato de haver nas suas reflexões um espaço conflitante que põe em discussão as fronteiras entre a filosofia e a lingüística nos estudos da linguagem.

  10. The IGU Knowledge Centre

    NARCIS (Netherlands)

    Huizing, Bernardus

    2005-01-01

    This article describes an innovative service for members of the International Gas Union - IGU. The IGU Knowledge Centre provides members with relevant information and data. In this article is described why, how and where.

  11. CENTRE FOR GEOMETRICAL METROLOGY

    DEFF Research Database (Denmark)

    De Chiffre, Leonardo

    The objective of this Annual Report is to give a general introduction to CGM as well as to give an account of the tasks carried out using the facilities of CGM's Instrument Centre during 1998 and 1999....

  12. Virtual particle therapy centre

    CERN Multimedia

    2015-01-01

    Particle therapy is an advanced technique of cancer radiation therapy, using protons or other ions to target the cancerous mass. This advanced technique requires a multi-disciplinary team working in a specialised centre. 3D animation: Nymus3D

  13. 82 Rubidium-PET kan blive den nye myokardieskintigrafi

    DEFF Research Database (Denmark)

    Hasbak, Philip; Kjær, Andreas

    2011-01-01

    -lived isotopes at centres with access to a cyclotron, and only including a very limited number of patients. The number of PET scanners has increased markedly in Denmark and with the introduction of generator-produced 82-Rubidium, this modality may replace the traditional cardial single photon emission computed......Since the 1970's nuclear cardiology has mainly been based on the use of gamma camera technology. While gamma cameras have undergone a rapid development, the number of perfusion tracers has been limited. In parallel, cardiac positron emission tomography (PET) has only been performed with short...

  14. The Bruce Energy Centre

    International Nuclear Information System (INIS)

    The Bruce Energy Centre Development Corporation is a joint venture of the Ontario Energy Corporation and 6 private companies formed to market surplus steam from the Bruce Nuclear Power Development. The corporation will also sell or lease land near Bruce NPD. The Bruce Energy Centre has an energy output of 900 BTU per day per dollar invested. Potential customers include greenhouse operators, aquaculturalists, food and beverage manufacturers, and traditional manufacturers

  15. Your Pet's Medications

    Science.gov (United States)

    ... by Animal/Species Browse by Topic Browse by Discipline Resources VMA Resource Center Tools for K-12 ... infection because giving the preventive to a heartworm-positive pet will not treat the infection and could ...

  16. Cold Weather Pet Safety

    Science.gov (United States)

    ... Emergency Care Animal Welfare Veterinary Careers Public Health Cold Weather Pet Safety Client Handout Available for download ... in hot cars , but did you know that cold weather also poses serious threats to your pets’ ...

  17. Clinical application of PET

    Energy Technology Data Exchange (ETDEWEB)

    Lomena, Francisco [Hospital Clinico Villarroel, Barcelona (Spain). Nuclear Medicine]. E-mail: flomena@clinic.ub.es; Soler, Marina [CETIR Grup Medic. Esplkugues de Llobregat, Barcelona (Spain). PET Unit

    2005-10-15

    Positron emission tomography (PET) is an imaging modality that gives information on tissue metabolism and functionalism, different from other imaging techniques like computed tomography (CT) and magnetic resonance imaging (MRI), which provide anatomical or structural information. PET has reached its development in biomedical research because of its capacity to use analogous compounds of many endogenous substance as tracers, and to measure, in vivo and in a non-invasive way, their consumption by the different organs and tissues of the mammalian body. Fluorodeoxyglucose-F 18 (FDG) PET has been proven to be a tracer adequate for clinical use in oncology and in many neurological diseases, with an excellent cost-efficiency ratio. The current PET-CT scanners can come to be the best tools for exploring patients who suffer from cancer.(author)

  18. Clinical application of pet

    OpenAIRE

    Francisco Lomeña; Marina Soler

    2005-01-01

    Positron emission tomography (PET) is an imaging modality that gives information on tissue metabolism and functionalism, different from other imaging techniques like computed tomography (CT) and magnetic resonance imaging (MRI), which provide anatomical or structural information. PET has reached its development in biomedical research because of its capacity to use analogous compounds of many endogenous substance as tracers, and to measure, in vivo and in a non-invasive way, their consumption ...

  19. PET/CT-guided percutaneous liver mass biopsies and ablations: Targeting accuracy of a single 20 s breath-hold PET acquisition

    International Nuclear Information System (INIS)

    Aim: To determine whether a single 20 s breath-hold positron-emission tomography (PET) acquisition obtained during combined PET/computed tomography (CT)-guided percutaneous liver biopsy or ablation procedures has the potential to target 2-[18F]-fluoro-2-deoxy-D-glucose (FDG)-avid liver masses as accurately as up to 180 s breath-hold PET acquisitions. Materials and methods: This retrospective study included 10 adult patients with 13 liver masses who underwent FDG PET/CT-guided percutaneous biopsies (n = 5) or ablations (n = 5). PET was acquired as nine sequential 20 s, monitored, same-level breath-hold frames and CT was acquired in one monitored breath-hold. Twenty, 40, 60, and 180 s PET datasets were reconstructed. Two blinded readers marked tumour centres on randomized PET and CT datasets. Three-dimensional spatial localization differences between PET datasets and either 180 s PET or CT were analysed using multiple regression analyses. Statistical tests were two-sided and p < 0.05 was considered significant. Results: Targeting differences between 20 s PET and 180 s PET ranged from 0.7–20.3 mm (mean 5.3 ± 4.4 mm; median 4.3) and were not statistically different from 40 or 60 s PET (p = 0.74 and 0.91, respectively). Targeting differences between 20 s PET and CT ranged from 1.4–36 mm (mean 9.6 ± 7.1 mm; median 8.2 mm) and were not statistically different from 40, 60, or 180 s PET (p = 0.84, 0.77, and 0.35, respectively). Conclusion: Single 20 s breath-hold PET acquisitions from PET/CT-guided percutaneous liver procedures have the potential to target FDG-avid liver masses with equivalent accuracy to 180 s summed, breath-hold PET acquisitions and may facilitate strategies that improve image registration and shorten procedure times

  20. The ideal Atomic Centre

    International Nuclear Information System (INIS)

    The author presents considerations which should prove to be of interest to all those who have to design, to construct and to operate a nuclear research centre. A large number of the ideas presented can also be applied to non-nuclear scientific research centres. In his report the author reviews: various problems with which the constructor is faced: ground-plan, infrastructure, buildings and the large units of scientific equipment in the centre, and those problems facing the director: maintenance, production, supplies, security. The author stresses the relationship which ought to exist between the research workers and the management. With this aim in view he proposes the creation of National School for Administration in Research which would train administrative executives for public or private organisations; they would be specialised in the fields of fundamental or applied research. (author)

  1. Quantitative FDG PET/CT in the community: experience from interpretation of outside oncologic PET/CT exams in referred cancer patients

    International Nuclear Information System (INIS)

    Tertiary care institutions often deal with patients who have had a baseline positron emission tomography (PET)/computed tomography (CT) scan performed elsewhere. Little data exist regarding the quality of these PET/CT scans and whether they are fully suitable for qualitative or quantitative interpretation. We evaluated outside PET/CT scans from cancer patients referred to our institution and compared them with PET/CT scans acquired locally. This Health Insurance Portability and Accountability Act-compliant retrospective study was approved by our institutional review board. Informed consent requirements were waived. One hundred seventy recent whole-body outside PET/CT exams from many sites were digitally imported into our radiology imaging system and reviewed for key quality metrics including time from injection until imaging, availability of patient height and weight information, serum glucose level and [18F]fluoro-2-deoxy-D-glucose (FDG) dose. The standardised uptake value (SUV) and SUV based on lean body mass (SUL) in the liver were measured whenever possible. These were compared with 170 internal studies performed at our centre during the same period. Missing data were common in outside scans with height in 62%, weight 35%, uptake time 25%, FDG dose 28% and glucose levels in 64% of cases. In quantitatively evaluable cases, mean liver SUL, SUV, FDG dose and uptake time were much more variable in outside than in internal studies. Approximately one-third of the outside PET/CT studies submitted digitally for analysis lacked key information required to secure any quantitative imaging data. Only about a third of these studies had all necessary information available for accurate SUL determination and had acceptable quality that was comparable with locally acquired scans. This suggests that many of PET studies performed in the community cannot be relied upon to provide quantitative image data that can be applied in a different centre. Greater standardisation of

  2. Lidar Calibration Centre

    Science.gov (United States)

    Pappalardo, Gelsomina; Freudenthaler, Volker; Nicolae, Doina; Mona, Lucia; Belegante, Livio; D'Amico, Giuseppe

    2016-06-01

    This paper presents the newly established Lidar Calibration Centre, a distributed infrastructure in Europe, whose goal is to offer services for complete characterization and calibration of lidars and ceilometers. Mobile reference lidars, laboratories for testing and characterization of optics and electronics, facilities for inspection and debugging of instruments, as well as for training in good practices are open to users from the scientific community, operational services and private sector. The Lidar Calibration Centre offers support for trans-national access through the EC HORIZON2020 project ACTRIS-2.

  3. Cardiac phantom measurement validating the methodology for a cardiac multi-centre trial with positron emission tomography.

    Science.gov (United States)

    Nuyts, Johan; Mortelmans, Luc; Van de Werf, Frans; Djian, Jacques; Sambuceti, Gianmario; Schwaiger, Marcus; Touboul, Paul; Maes, Alex

    2002-12-01

    In an ongoing international multi-centre trial, positron emission tomography (PET) is being used to evaluate the effect of a new P-selectin antagonist on the infarct size in patients with acute myocardial infarction, treated with thrombolysis. Although it is possible to correct for site-dependent factors, it is desirable to reduce these factors to a minimum. Therefore, acquisition and reconstruction protocols have been defined that can be closely followed by all participating centres. The resulting reconstructed images are transferred to the core centre for central processing with semi-automatic software. This paper reports on the multi-centre phantom experiment that was carried out to assess the inter-centre reproducibility of defect size determination with this protocol. Also, the spatial resolution of the short axis slices was examined. In addition, the analysis procedure was applied to normal PET studies to evaluate the specificity of perfusion defect detection. The transmural cold defect in the phantom occupied 14.8% of the left ventricular area. The automated analysis was applied to the phantom measurements from the 14 participating PET cameras. It yielded an accurate estimate of 15.1% with a standard deviation of 0.6%, indicating excellent reproducibility. The spatial resolution in the short axis slices was similar for all PET systems: 9.6+/-0.8 mm. The same procedure produced a defect size of zero in the studies of normal volunteers. This study indicates that cardiac studies from multiple PET systems can be pooled for statistical analysis.

  4. Cardiac phantom measurement validating the methodology for a cardiac multi-centre trial with positron emission tomography

    Energy Technology Data Exchange (ETDEWEB)

    Nuyts, Johan; Mortelmans, Luc; Maes, Alex [Nuclear Medicine, UZ Gasthuisberg, K.U. Leuven, Herestraat 49, 3000 Leuven (Belgium); Van de Werf, Frans [Cardiology, UZ Gasthuisberg, K.U. Leuven, Leuven (Belgium); Djian, Jacques [Wyeth Research, Paris la Defense Cedex (France); Sambuceti, Gianmario [Instituto di Fisiologia Clinica CNR, Pisa (Italy); Schwaiger, Marcus [Nuklearmedizinische Klinik und Poliklinik, TU Muenchen, Muenchen (Germany); Touboul, Paul [Hopital Cardio-Vasculaire et Pneumologique, Lyon (France)

    2002-12-01

    In an ongoing international multi-centre trial, positron emission tomography (PET) is being used to evaluate the effect of a new P-selectin antagonist on the infarct size in patients with acute myocardial infarction, treated with thrombolysis. Although it is possible to correct for site-dependent factors, it is desirable to reduce these factors to a minimum. Therefore, acquisition and reconstruction protocols have been defined that can be closely followed by all participating centres. The resulting reconstructed images are transferred to the core centre for central processing with semi-automatic software. This paper reports on the multi-centre phantom experiment that was carried out to assess the inter-centre reproducibility of defect size determination with this protocol. Also, the spatial resolution of the short axis slices was examined. In addition, the analysis procedure was applied to normal PET studies to evaluate the specificity of perfusion defect detection. The transmural cold defect in the phantom occupied 14.8% of the left ventricular area. The automated analysis was applied to the phantom measurements from the 14 participating PET cameras. It yielded an accurate estimate of 15.1% with a standard deviation of 0.6%, indicating excellent reproducibility. The spatial resolution in the short axis slices was similar for all PET systems: 9.6{+-}0.8 mm. The same procedure produced a defect size of zero in the studies of normal volunteers. This study indicates that cardiac studies from multiple PET systems can be pooled for statistical analysis. (orig.)

  5. International research centre launched

    International Nuclear Information System (INIS)

    Full text: The first scientific research and educational institution to be set up on a completely international basis was officially inaugurated in Trieste on 5 October 1964 by the Director General of IAEA, Dr. Sigvard Eklund, when he opened the first seminar of the International Centre for Theoretical Physics. As evidence of the international nature of the institution he noted that the scientists who would work and teach there during the first year represented sixteen different countries. By the end of 1964, the Centre building was nearing completion and three of the five floors were occupied. A successful symposium had been held on the subject of plasma physics, and a score of professors and fellows were at work, from Bulgaria, Czechoslovakia, Greece, India, Japan, Jordan, the Netherlands, Norway, Pakistan, Poland, the United Kingdom, and the United States. A dozen scientific papers had been issued as preprints. The main purpose of the Centre is to foster the advancement of theoretical physics through training and research; at first the chief subject will be high-energy and elementary particle physics. Plasma physics, low energy physics and solid-state physics will also be dealt with. Special attention is paid to the needs of the developing countries. Of the 25 fellows selected for the academic year 1964-65, more than half are from South America, Africa and Asia. In conjunction with the Research Centre, there is an Advanced School for theoretical Physics to provide graduate training for fellows who need such preparation before they embark upon research. The Centre works under the guidance of a Scientific Council comprising the president, Prof. M. Sandoval-Vallarta (Nuclear Energy Commission of Mexico); Prof. A. Abragam (Saclay, France); Prof. R. Oppenheimer (Institute for Advanced Study, Princeton, USA); Dr. V. Soloviev (Dubna, USSR); Prof V.F. Weiskopf (Director General, CERN) ; Prof Abdus Salam (Imperial College, London) ; Prof. P. Budini (University of Trieste

  6. Toward a renewable-energy future: the urban potential - Austin, Texas

    Energy Technology Data Exchange (ETDEWEB)

    1982-01-01

    The kind and quality of Austin, Texas' energy sources and its pattern of energy consumption are analyzed, followed by an analysis of conservation and solar energy in residential and commercial structures, justifications for instituting a solar energy code, and the prospect of small business opportunities in solar energy. The possibility of converting municipal solid wastes to energy and the role of the city's electric department in promoting the use of renewable resources are examined. The outline is provided of an information/skills transfer program that can be used to increase public awareness, receptivity, and confidence in renewable energy alternatives. (LEW)

  7. Silicates and variability in comets Okazaki-Levy-Rudenko (1989r) and Austin (1989c1)

    Science.gov (United States)

    Russell, Ray W.; Lynch, David K.

    1990-01-01

    Comet Okazaki-Levy-Rudenko (1989r) was studied over a wide range of wavelengths from the UV to the submillimeter. Using visual magnitude estimates from the IAU Circulars and reported submillimeter fluxes in conjunction with the thermal infrared spectroscopy and filter photometry, the nature of the grains and the behavior of the comet can be assessed and compared to other comets studied under this program. In addition, preliminary results from a collaborative infrared study of Comet Austin are presented which address the nature of the dust in that comet. Progress on a model for cometary properties and brightness behavior is discussed.

  8. PAH Concentrations Decline Following 2006 Ban on Coal-Tar-Based Pavement Sealants in Austin, Texas

    Science.gov (United States)

    Van Metre, P. C.; Mahler, B. J.

    2013-12-01

    Recent studies have concluded that coal-tar-based pavement sealants (CT sealants) are a major source of polycyclic aromatic hydrocarbons (PAHs) in non-industrial urban settings in the United States. In 2006, Austin, TX, became the first jurisdiction in the U.S. to ban the use of CT sealants. We evaluated PAH concentrations following the ban by analyzing sediment cores collected from Lady Bird Lake in 2012; Lady Bird Lake impounds the Colorado River in central Austin and receives runoff from much of the greater Austin area. The mean sum concentration of the 16 U.S. Environmental Protection Agency Priority Pollutant PAHs (∑PAH16) in one of two 2012 sediment cores analyzed for PAHs declined 75% from before 2006 (mean of 4 samples=8,090 μg kg-1) to 2012 (mean of 2 samples=2,030 μg kg-1), reversing a 40-year (1959-1999) upward trend in PAH concentrations that was previously documented. The downward trend in PAH concentrations in the seven uppermost 1 cm sampling intervals in the first 2012 core was statistically significant (r=0.93, p-value=0.002). Post-2008 PAH trends in the second 2012 core were similar (significant downward trend in the six uppermost 1 cm sampling intervals and mean 2012 ∑PAH16 of 2,390 μg kg-1); however, pre-2007 sediment did not appear to have been preserved in this core likely because of the effects of flooding on sediment deposition and mixing at this site--the largest flood on the Colorado River in Austin in 20 years was in 2007. On the basis of a comparison of lake-sediment PAH profiles to 22 PAH source profiles, the PAH loading to lake sediment continues to be dominated by CT sealants. The continued dominance of proportional PAH loading by CT sealants in spite of decreased concentrations since 2006 might be because legacy CT sealant and contaminated soils and sediments continue to yield PAHs to runoff. A previous study using source-receptor modeling concluded that CT sealants were the largest PAH source to 40 urban lakes studied in the

  9. Post-target produced [18F]F2 in the production of PET radiopharmaceuticals

    International Nuclear Information System (INIS)

    Electrophilic radiofluorination was successfully carried out in the early years of PET radiochemistry due to its ease and fast reaction speed. However, at the present, the use of electrophilic methods is limited due to low specific activity (SA). Post-target produced [18F]F2 has significantly higher SA compared to other electrophilic approaches, and it has been used in the production of clinical PET radiopharmaceuticals at the Turku PET Centre for years. Here, we summarize the synthesis and use of these radiopharmaceuticals, namely [18F]FDOPA, [18F] CFT, [18F]EF5 and [18F]FBPA.

  10. Medical application of PET technology

    Energy Technology Data Exchange (ETDEWEB)

    Lim, Sang Moo; Choi, C. W.; An, S. H.; Woo, K. S.; Chung, W. S.; Yang, S. D.; Jun, G. S. and others

    1999-04-01

    We performed following studies using PET technology: 1. Clinical usefulness of [{sup 18}F]FDG whole body PET in malignant disease 2. Clinical usefulness of quantitative evaluation of F-18-FDG 3. Pilot study of C-11 methionine PET in brain tumor 4. PET study in patients with Parkinson's disease 5. A study on the clinical myocardial PET image. PET gives various metabolic information for the living human body, and is very important, new diagnostic modality. The PET study will give us the information of cancer patients such as early detection of cancer, staging, recurrence detection and characterization of cancer. The quantitative analysis using PET could be applied to evaluate the pathophysiology of various diseases and develop new drugs and develop new radiopharmaceuticals.

  11. Medical application of PET technology

    International Nuclear Information System (INIS)

    We performed following studies using PET technology: 1. Clinical usefulness of [18F]FDG whole body PET in malignant disease 2. Clinical usefulness of quantitative evaluation of F-18-FDG 3. Pilot study of C-11 methionine PET in brain tumor 4. PET study in patients with Parkinson's disease 5. A study on the clinical myocardial PET image. PET gives various metabolic information for the living human body, and is very important, new diagnostic modality. The PET study will give us the information of cancer patients such as early detection of cancer, staging, recurrence detection and characterization of cancer. The quantitative analysis using PET could be applied to evaluate the pathophysiology of various diseases and develop new drugs and develop new radiopharmaceuticals

  12. Academic Drug Discovery Centres

    DEFF Research Database (Denmark)

    Kirkegaard, Henriette Schultz; Valentin, Finn

    2014-01-01

    Academic drug discovery centres (ADDCs) are seen as one of the solutions to fill the innovation gap in early drug discovery, which has proven challenging for previous organisational models. Prior studies of ADDCs have identified the need to analyse them from the angle of their economic...

  13. Implementing Responsibility Centre Budgeting

    Science.gov (United States)

    Vonasek, Joseph

    2011-01-01

    Recently, institutes of higher education (universities) have shown a renewed interest in organisational structures and operating methodologies that generate productivity and innovation; responsibility centre budgeting (RCB) is one such process. This paper describes the underlying principles constituting RCB, its origin and structural elements, and…

  14. ATLAS Visitors Centre

    CERN Multimedia

    claudia Marcelloni

    2009-01-01

    ATLAS Visitors Centre has opened its shiny new doors to the public. Officially launched on Monday February 23rd, 2009, the permanent exhibition at Point 1 was conceived as a tour resource for ATLAS guides, and as a way to preserve the public’s opportunity to get a close-up look at the experiment in action when the cavern is sealed.

  15. Novel PET sensors

    International Nuclear Information System (INIS)

    This thesis describes the design, synthesis and evaluation of novel molecular sensors that utilize the phenomena of Photoinduced Electron Transfer (PET). PET design can be incorporated into molecules to allow them to selectively bind certain guest molecules. PET works by the modulation of electron potentials within a molecule. Binding events between a host and guest can, if designed suitably, change these potentials enough to cause a transfer of electronic charge within the molecular sensor. This event can be accurately and sensitively monitored by the use of ultra violet or fluorescence spectroscopy. A sensor molecule can be constructed by matching the guest to a suitable receptor site and incorporating this into a molecule containing a fluorophore with the correct electron potential characteristics. By using existing synthetic routes as well as exploiting new pathways these sensor molecules C n be constructed to contain a fluorophore separated from a guest receptor(s) by suitable spacers units. When put together these facets go to creating molecules that by design are sensitive and selective for certain guest molecules or functional groups. This methodology allows the synthetic chemist to rationally design and synthesise PET sensors, tailored to the needs of the guest. In this thesis the synthesis and evaluation of a novel PET sensors for D-glucosamine, disaccharides and fluoride is presented. It is believed that the novel sensors using the PET phenomenon presented in this thesis are a worthwhile extension of previous works undertaken by other groups around the world and shows new pathways to increasingly complex and sophisticated sensor molecular design. (author)

  16. Overview on impact of PET at the general public level

    International Nuclear Information System (INIS)

    several years to reach nearly 200 with over 300 PET or PET/CT being used. In Japan PET/CT procedures have frequently been used outside of NHIS to be applied to health checkup of healthy subjects, mainly cancer screening purpose. This trend reflects the increasing societal interest towards preventive medicine. It is expected that some invasive technologies may be avoided by the introduction of PET/CT. Large scale PET imaging centres such as with 10 PET scanners and 2 cyclotrons are operated. For the production and delivery of FDG to cover all over Japan 9 branch factories with cyclotrons and automated synthesis and labeling systems were constructed by a radiopharmaceutical company. Obviously this trend has stimulated related industries. Radiation protection of workers is another important issue when PET and PET/CT became so popular. Training of PET/CT specialists is also an urgent problem to solve in order to maintain high quality of image interpretation. Prevailing use of PET/CT will change the practice and education of diagnostic imaging, in that PET/nuclear medicine specialists cooperate with CT/diagnostic radiology specialists. Although FDG PET is a useful tool of cancer detection as widely recognized among the general public in Japan, FDG is not necessarily the ideal tracer for cancer detection. The efforts have to be made to develop better radiopharmaceuticals. Oncology is not the only field PET can contribute, either. It will play important roles in clinical neurology and psychiatry not to mention in cardiology in near future. Progress of molecular biology and nanotechnology has reached the phase that seeks for their clinical applications. PET is one of the most advanced and promising tool at present to trace the gene expression and dynamics of protein and other molecules in human. And thus it will contribute clinically to gene therapy and regenerative medicine by providing better management of patients in Continuous research is needed to improve the current

  17. Clinical application of pet

    Directory of Open Access Journals (Sweden)

    Francisco Lomeña

    2005-10-01

    Full Text Available Positron emission tomography (PET is an imaging modality that gives information on tissue metabolism and functionalism, different from other imaging techniques like computed tomography (CT and magnetic resonance imaging (MRI, which provide anatomical or structural information. PET has reached its development in biomedical research because of its capacity to use analogous compounds of many endogenous substance as tracers, and to measure, in vivo and in a non-invasive way, their consumption by the different organs and tissues of the mammalian body. Fluordeoxyglucose-F18 (FDG PET has been proven to be a tracer adequate for clinical use in oncology and in many neurological diseases, with an excellent cost-efficiency ratio. The current PET-CT scanners can come to be the best tools for exploring patients who suffer from cancer.A tomografia por emissão de pósitrons (PET é uma técnica de diagnóstico por imagem que fornece informação sobre o metabolismo e funcionamento dos tecidos, diferente de outras técnicas de imagens como tomografia computadorizada (TC e ressonância magnética (RM, as quais fornecem informações estruturais ou anatômicas. O PET alcançou seu desenvolvimento em investigação biomédica devido à sua capacidade de usar traçadores análogos a muitas substâncias endógenas e de medir in vivo e de forma não invasiva seu consumo em diferentes órgãos e tecidos dos mamíferos 18Fluordesoxiglicose (FDG PET tem provado ser uma exploração de uso clínico com excelente relação custo benefício em oncologia e em muitas doenças neurológicas. Os atuais tomógrafos por PET-CT podem chegar a ser a melhor ferramenta de diagnóstico nos pacientes que sofrem de câncer.

  18. Integration of multi-objective structural optimization into cementless hip prosthesis design: Improved Austin-Moore model.

    Science.gov (United States)

    Kharmanda, G

    2016-11-01

    A new strategy of multi-objective structural optimization is integrated into Austin-Moore prosthesis in order to improve its performance. The new resulting model is so-called Improved Austin-Moore. The topology optimization is considered as a conceptual design stage to sketch several kinds of hollow stems according to the daily loading cases. The shape optimization presents the detailed design stage considering several objectives. Here, A new multiplicative formulation is proposed as a performance scale in order to define the best compromise between several requirements. Numerical applications on 2D and 3D problems are carried out to show the advantages of the proposed model. PMID:27028554

  19. Elderly Care Centre

    Science.gov (United States)

    Wagiman, Aliani; Haja Bava Mohidin, Hazrina; Ismail, Alice Sabrina

    2016-02-01

    The demand for elderly centre has increased tremendously abreast with the world demographic change as the number of senior citizens rose in the 21st century. This has become one of the most crucial problems of today's era. As the world progress into modernity, more and more people are occupied with daily work causing the senior citizens to lose the care that they actually need. This paper seeks to elucidate the best possible design of an elderly care centre with new approach in order to provide the best service for them by analysing their needs and suitable activities that could elevate their quality of life. All these findings will then be incorporated into design solutions so as to enhance the living environment for the elderly especially in Malaysian context.

  20. PET/MR in oncology

    DEFF Research Database (Denmark)

    Balyasnikova, Svetlana; Löfgren, Johan; de Nijs, Robin;

    2012-01-01

    of the challenges inherent in this new technology, but focus on potential applications for simultaneous PET/MR in the field of oncology. Methods and tracers for use with the PET technology will be familiar to most readers of this journal; thus this paper aims to provide a short and basic introduction to a number...... be applied together with PET increasing the amount of information about the tissues of interest. The potential clinical benefit of applying PET/MR in staging, radiotherapy planning and treatment evaluation in oncology, as well as the research perspectives for the use of PET/MR in the development of new...

  1. Simultaneous PET and MR imaging

    International Nuclear Information System (INIS)

    We have developed a prototype PET detector which is compatible with a clinical MRI system to provide simultaneous PET and MR imaging. This single-slice PET system consists of 48 2x2x10mm3 LSO crystals in a 38 mm diameter ring configuration that can be placed inside the receiver coil of the MRI system, coupled to three multi-channel photomultipliers housed outside the main magnetic field via 4 m long and 2 mm diameter optical fibres. The PET system exhibits 2 mm spatial resolution, 41% energy resolution at 511 keV and 20 ns timing resolution. Simultaneous PET and MR phantom images were successfully acquired. (author)

  2. Healthy Pets and People

    Science.gov (United States)

    ... food and treats might include dry dog or cat food, dog biscuits, pig ears, beef hooves, and rodents ... after your pet, and before eating or preparing foods. Make sure to remove your ... contain dog or cat feces to prevent the spread of roundworms and ...

  3. I Love Petting Zoos!

    Centers for Disease Control (CDC) Podcasts

    2010-03-23

    This Kidtastics podcast helps children learn about how to stay safe and healthy when visiting petting zoos and other animal exhibits.  Created: 3/23/2010 by Centers for Disease Control and Prevention (CDC).   Date Released: 3/23/2010.

  4. Polyesteramides based on PET

    NARCIS (Netherlands)

    Bouma, Krista

    1999-01-01

    Engineering plastics have good mechanical, thermal and electrical properties, and can be easily processed. Typical engineering plastics include polyamides (PA6,6, PA6, PA4,6) and polyesters (PBT, PET). Compared to polyesters of a similar structure, polyamides have a high glass transition (Tg) and me

  5. Combined PET/MRI

    DEFF Research Database (Denmark)

    Bailey, D. L.; Pichler, B. J.; Gückel, B.;

    2015-01-01

    February 23 to 27, 2015. Specifically, we summarise the three days of invited presentations from active researchers in this and associated fields augmented by round table discussions and dialogue boards with specific topics. These include the use of PET/MRI in cardiovascular disease, paediatrics, oncology......, the conclusion of last year's meeting "the real work has just started" still holds true....

  6. PET CT and lymphomas

    International Nuclear Information System (INIS)

    This presentation is about Tc and lymphomas. Classification and clinical cases of various cancer such as gastro duodenal or ulcer, mama, medullary, lymph and neck, leukemia, nodular sclerosis. Metabolic information, anatomical nature of lymphoma and its clinical presentation determine the extent that PET should be used in the patient.

  7. PET and PET/CT in malignant melanoma; PET y PET/CT en melanoma maligno

    Energy Technology Data Exchange (ETDEWEB)

    Garcia O, J.R. [Nuclear Medicine and Molecular Imaging PET/CT, Centro Medico ABC, Mexico D.F. (Mexico)

    2007-07-01

    The advantages that it has the PET/CT are: 1. It diminishes mainly positive false lesions. It identifies physiologic accumulate places. 2. It diminishes in smaller grade false negative. Small injuries. Injuries with low grade concentration. Injure on intense activity areas. 3. Precise anatomical localization of accumulate places. 4. Reduction of the acquisition time. (Author)

  8. Choosing a Pet

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    THE capital boasts countless markets of all kinds,but some of its insect,bird and pet markets immortalize Beijing culture and folkloric traditions.Don’t miss it! The Huasheng Tianqiao Market,south of the famous Panjiayuan Antique Market, was moved a few years ago and rebuilt in the

  9. Tele-centres in Ghana

    DEFF Research Database (Denmark)

    Falch, Morten

    2004-01-01

    Tele-centres offer a low cost opportunity for the many who cannot afford their own phone or Internet connection. This paper presents a field study of tele-centres in Ghana and analyses how they contribute to universal access.......Tele-centres offer a low cost opportunity for the many who cannot afford their own phone or Internet connection. This paper presents a field study of tele-centres in Ghana and analyses how they contribute to universal access....

  10. In-beam PET data characterization with the large area DoPET prototype

    Science.gov (United States)

    Sportelli, G.; Belcari, N.; Camarlinghi, N.; Ciocca, M.; Collini, F.; Molinelli, S.; Pullia, M.; Zaccaro, E.; Del Guerra, A.; Rosso, V.

    2016-02-01

    Range verification with in-beam PET techniques is a powerful tool for monitoring the correctness of dose delivery in particle therapy. Among the major limitations of in-beam PET systems are the limited detectors size due to the constrained space in which they can be placed to allow the irradiation, and the necessity of a high read-out modularization, due to high activity rates during the irradiation. In this work we present the data acquired at the CNAO (Centro Nazionale di Adroterapia Oncologica) treatment center in Pavia, Italy, with the new DoPET system, specifically designed to operate in in-beam conditions. The new prototype consists of two planar 15cm × 15cm LYSO-based detectors, read out by 9 PMT detector modules each. In particular, we test the capability of our system to determine particle range in various irradiation conditions. Several plastic phantoms were irradiated at the CNAO treatment centre with protons and carbon ions of various energies. The used dose in treatment plans is 2 Gy and the monitoring feedback is produced in a few minutes after the end of the treatment.

  11. 77 FR 8806 - Foreign-Trade Zone 183-Austin, TX; Application for Reorganization Under the Alternative Site...

    Science.gov (United States)

    2012-02-15

    ...)--Hill Partners within the Global Business Park, Rutherford Lane/Cameron Road, Austin; Site 14 (91 acres... reorganize the zone under the alternative site framework (ASF) adopted by the Board (74 FR 1170- 1173, 01/12/09 (correction 74 FR 3987, 01/22/09); 75 FR 71069-71070, 11/22/10). The ASF is an option for...

  12. DGNB certified Healthcare Centres

    DEFF Research Database (Denmark)

    Brunsgaard, Camilla; Larsen, Tine Steen

    2015-01-01

    for sustainability and wants a certification. This research investigates the decision‐making and design process (DMaDP) behind four DGNB certified Healthcare Centres (HCC) in Northern Jutland in Denmark. In general, knowledge about the DMaDP is important. However it is important to know what part DGNB plays...... a dialog about DGNB and energy concept is important even before anyone start sketching. Experiences with the different approaches will be further outlined in the paper.Future research has the intention to collect further knowledge about DGNB and DMaDP in practise. This project was limited to Healthcare...

  13. Centre liikekeskuksen digital signage

    OpenAIRE

    Bincl, Suzana

    2015-01-01

    Opinnäytetyöni tarkastelee digital signagen suunnittelussa huomioitavia tekijöitä ja sen arvoa markkinointikanavana. Työ on toteutettu tilaustyönä Lappeenrantalaiselle mainostoimisto Mediakolmiolle. Työ sisältää teoriaosuuden lisäksi sisältösuunnitelman rakenteilla olevalle Centre liikekeskukselle. Tavoitteena oli luoda liikekeskukselle sen brändiä tukeva digital signage konsepti. Työ ei sisällä valmista tuotetta, vaan se toimii ehdotelmana myöhemmin alkavalle tuotanno...

  14. Town Centre Redevelopment Strategies

    DEFF Research Database (Denmark)

    Vagnby, Bo Hellisen

    urban planning and design strategieswhich have been practised in most of the larger Danish towns: pedestrian streets, shopping centres, preservation of historic features, waterfronts, concentration of offices, conference and sports facilities, improvement og traffic and transport conditions as well...... as slum clearence and urban renewal. To a certain extent parallels are drawn to international experiences, especially where these are of such a nature that they can be assumed transferred to Danish connctions. Conclusively, the strategies are discussed in the light of the turn of Danish urban planning...

  15. Construction and characterization of the redesigned PGAA facility at The University of Texas at Austin

    Energy Technology Data Exchange (ETDEWEB)

    Revay, Zs. [Institute of Isotopes, Hungarian Academy of Sciences, Budapest (Hungary)]. E-mail: revay@iki.kfki.hu; Harrison, R.K. [Nuclear Engineering Teaching Laboratory, The University of Texas at Austin (United States); Alvarez, E. [Nuclear Engineering Teaching Laboratory, The University of Texas at Austin (United States); Biegalski, S.R. [Nuclear Engineering Teaching Laboratory, The University of Texas at Austin (United States); Landsberger, S. [Nuclear Engineering Teaching Laboratory, The University of Texas at Austin (United States)

    2007-07-11

    The prompt gamma activation analysis (PGAA) facility at The University of Texas at Austin (UT) has been redesigned and reconstructed. As a result of the new shielding of the system, the neutron (at all energies) and gamma-ray backgrounds have been reduced by more than an order of magnitude, considerably improving the signal-to-noise ratio for the characteristic peaks. The prompt gamma peaks from the construction materials have also been decreased, providing better detection limits for elements. The calibration of the new system is shown in detail. All these efforts significantly improved the sensitivity and reliability of the chemical analyses performed in the facility. The characteristics of the improved PGAA system are also presented.

  16. Effects of storm-water runoff on water quality of the Edwards Aquifer near Austin, Texas

    Science.gov (United States)

    Andrews, Freeman L.; Schertz, Terry L.; Slade, Raymond M.; Rawson, Jack

    1984-01-01

    Analyses of samples collected from Barton Springs at approximately weekly Intervals and from Barton Creek and five wells in the Austin area during selected storm-runoff periods generally show that recharge during storm runoff resulted in significant temporal and area! variations in the quality of ground water in the recharge zone of the Edwards aquifer. Recharge during storm runoff resulted in significant increases of bacterial densities in the ground water. Densities of fecal coliform bacteria in samples collected from Barton Springs, the major point of ground-water discharge, ranged from less than 1 colony per 100 milliliters during dry weather in November 1981 and January and August 1982 to 6,100 colonies per 100 milliliters during a storm in May 1982. Densities of fecal streptococcal bacteria ranged from 1 colony per 100 miniliters during dry weather in December 1981 to 11,000 colonies per 100 miniliters during a storm in May 1982.

  17. Locuciones Ejecutivas - J. L. Austin: Cómo hacer cosas con palabras

    Directory of Open Access Journals (Sweden)

    Mirko Skarica

    2010-01-01

    Full Text Available This translation is performed within a working group of the Institute of Philosophy at the Universidad Católica de Valparaiso. This working group is composed of teachers Laura V. Palma, Sylvia Escobar Toledo, Mirko and Hernan Zomosa Skarica, and it has been proposed as a research topic semantic theories of Austin and his closest followers. The translation of "Performative Utterances" has been one result of the plan of work carried out during the second half of 1971. Before writing the translation definitely offered here, his first writing in Castilian was studied in the seminar on the author by Mirko Skarica at the Institute of Philosophy (UCV in the second half of 1971. The translators especially appreciate the students of that seminar for all the valuable suggestions they made during the discussion of the text.

  18. LEUCEMIAS Y RADIACIÓN: JUICIO CAUSAL SEGÚN LOS CRITERIOS DE SIR AUSTIN BRADFORD HILL Causal judgment by Sir Austin Bradford Hill criteria: leukemias and radiation

    Directory of Open Access Journals (Sweden)

    Octavio Martínez Betancur

    2010-07-01

    Full Text Available El cometido del presente trabajo es la lectura interpretativa con base en la propuesta de inferencia causal de Austin Bradford Hill, del documento Radiation-related leukemia in Hiroshima and Nagasaki, 1946-1964. I. Distribution, incidence and appearance time. El documento informado por el comité de las víctimas de la bomba atómica cumple con la totalidad de los nueve "criterios" propuesto por Hill, y entre las limitaciones se cuentan la presunciones de homogeneidad genética de los sujetos expuestos y linealidad de los efectos de las radiaciones en la leucemia, además del hecho de sólo considerar la edad como variable confusora. Por otra parte, el número de muertes por leucemia, patrón de oro de la sensibilidad y la especificidad del sistema de vigilancia del estudio de duración de la vida, fue 61 muertes por leucemia entre los supervivientes situados dentro de 1500 metros del epicentro de la explosión y 25 muertes en el grupo que recibió radiación estando entre 1501 y 10000 metros, lo que habla de posible subregistro de casos y de sobrediagnóstico por la sumatoria de criterios empleados. Los "criterios" de Hill no son reglas lógicas sino metodológicas, que ayudan en el proceso de decisión sobre la inferencia causal en epidemiología. Se apartan de la discusión de si las inferencias a partir de ellos se ajustan a la lógica inductiva o a la deductiva, y deben entenderse pragmáticamente como "inferencias de la mejor explicación" en el contexto de la abducción. La única conclusión permitida dentro del marco de la "inferencia de la mejor explicación", es que se tienen buenas razones para considerar seriamente la hipótesis que la asociación estadística que se estudia, es una relación causal.This paper presents an interpretive reading based on the proposed causal inference by Austin Bradford Hill; of the document "Radiation-related leukemia in Hiroshima and Nagasaki, 1946-1964. I. Distribution, incidence, and Appearance time

  19. Are Pets Good For Us?

    Institute of Scientific and Technical Information of China (English)

    邢连香

    2006-01-01

    A pet animal keeps us feel happy.Pets can staywith us when we are left by ourselves,and pets in-vite us to love and be loved.Often a cat or dog cankeep us easy at time when human words don’t help.Pets also keep us get close to the more natural animalworld.Learning to care for a pet helps a child to growup into a loving man or woman who feels responsible(有责任的) towards those dependent (依靠) on him.A pet dog can make us believe in others for we cansee faithfulness (忠诚) in the dog.In fact,we keeppets not only fo...

  20. Usage of Recycled Pet

    OpenAIRE

    A. Ebru Tayyar; Sevcan Üstün

    2010-01-01

    The increasing industrialization, urbanization and the technological development have caused to increase depletion of the natural resources and environmental pollution's problem. Especially, for the countries which have not enough space recycling of the waste eliminating waste on regular basis or decreasing the amount and volume of waste have provided the important advantages. There are lots of studies and projects to develop both protect resources and prevent environmental pollution. PET bot...

  1. PET studies in dementia

    International Nuclear Information System (INIS)

    Measurement of local cerebral glucose metabolism (lCMRGlc) by positron emission tomography (PET) and 18F-2-fluoro-2-deoxy-D-glucose (FDG) has become a standard technique during the past 20 years and is now available at many university hospitals in all highly developed countries. Many studies have documented a close relation between lCMRGlc and localized cognitive functions, such as language and visuoconstructive abilities. Alzheimer's disease (AD) is characterized by regional impairment of cerebral glucose metabolism in neocortical association areas (posterior cingulate, temporoparietal and frontal multimodal association cortex), whereas primary visual and sensorimotor cortex, basal ganglia, and cerebellum are relatively well preserved. In a multicenter study comprising 10 PET centers (Network for Efficiency and Standardization of Dementia Diagnosis, NEST-DD) that employed an automated voxel-based analysis of FDG PET images, the distinction between controls and AD patients was 93% sensitive and 93% specific, and even in very mild dementia (at Mini Mental Status Examination (MMSE) 24 or higher) sensitivity was still 84% at 93% specificity. Significantly abnormal metabolism in mild cognitive deficit (MCI) indicates a high risk to develop dementia within the next two years. Reduced neocortical glucose metabolism can probably be detected with FDG PET in AD on average one year before onset of subjective cognitive impairment. In addition to glucose metabolism, specific tracers for dopamine synthesis (18F-F-DOPA) and for (11C-MP4A) are of interest for differentiation among dementia subtypes. Cortical acetylcholine esterase activity (AChE) activity is significantly lower in patients with AD or with dementia with Lewy bodies (DLB) than in age-matched normal controls. In LBD there is also impairment of dopamine synthesis, similar to Parkinson disease. (author) 115 refs

  2. PET and Recycling

    Directory of Open Access Journals (Sweden)

    Funda Sevencan

    2007-08-01

    Full Text Available This review aims to clarify the need of decreasing the environmental effects caused by human and draw attention to the increasing environmental effects of plastics wastes. Plastics consist of organic molecules with high density molecules or polymers. Main resources of plastics are the residue of oil rafineries. Several advantages of plastics, have increased the usage continuously. Polyethylene Terephthalate (PET is the most commonly used plastics. PET is used to protect food, drinking water, fruit juice, alcoholic beverage, and food packing films. By the increasing interest on the environmental effects of plastic wastes, concerns on the recyclable packing materials also grew up. Also the daily use of recyclable containers consisting PET have increased. There are five steps for recycling of plastics. These steps are; using large amounts of plastics, collecting them in a big center, classifying and sorting the plastics, reproducing the polymers and obtaining new products with melted plastics. Providing a healthy recycling of plastics, the consumers should have knowledge and responsibility. The consumer should know what he/she has to do before putting the plastics in the recycling containers. Recycling containers and bags should be placed near the sources of plastic wastes. Consequently, the plastic wastes and environmental problems they cause will be on the agenda in future. [TAF Prev Med Bull. 2007; 6(4: 307-312

  3. PET radiopharmaceuticals for neuroreceptor imaging

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    Routine clinical PET radiopharmaceuticals for the noninvasive imaging of brain receptors, transporters,and enzymes are commonly labeled with positron emitting nuclides such as carbon-11 or fluorine-18. Certain minimal conditions need to be fulfilled for these PET ligands to be used as imaging agents in vivo. Some of these prerequisites are discussed and examples of the most useful clinical PET radiopharmaceuticals that have found application in the central nervous system are reviewed.

  4. Pet Overpopulation: An Economic Analysis

    OpenAIRE

    Coate, Stephen; Knight, Brian

    2009-01-01

    This paper considers the problem of pet overpopulation. It develops a tractable dynamic model whose positive predictions square well with key features of the current U.S. market for pets. The model is used to understand, from a welfare economic perspective, the sense in which there is \\overpopulation" of pets and the underlying causes of the problem. The paper also employs the model to consider what policies might be implemented to deal with the problem. A calibrated example is developed to i...

  5. Client services for geriatric pets.

    Science.gov (United States)

    Hancock, G; Yates, J

    1989-01-01

    Some veterinarians have been reluctant to discuss the prospect of the death of a pet because of a sense of discomfort and a lack of understanding about how to respond to the client's grief reaction. It is essential to take the time for this important communication and help clients deal with fears about the process, any feelings of guilt and helplessness, and judgments about the medical aspects of a case. Clients must be encouraged to express grief over the loss of a pet, particularly a geriatric pet that has lived with them many years and to which they are deeply bonded. Veterinarians need to counsel clients about obtaining additional pets or another pet. The phrase "replacement pet" must be stricken from the veterinarian's vocabulary. One does not "replace" a deceased spouse, mother, father, or child. It is possible to have another child or find another spouse, but it is not possible to replace a person. Neither can a pet be "replaced," because each pet is a unique living being. It is disrespectful to the memory of deceased pets to belittle their uniqueness by suggesting that they can be replaced. Instead, the veterinarian has the capability and responsibility to help pet owners maintain fond and happy memories of an irreplacable pet, while finding room in their hearts for another new pet to create happiness for the future. Once the grief is resolved, clients will be thankful for having had the privilege of sharing their life with an animal and experiencing the joy of the bond between two unique individuals. PMID:2646816

  6. Cyclotron/PET project in Uruguay

    International Nuclear Information System (INIS)

    The Positron Computed Tomography (PET) is a tri dimensional image technique which shows biochemical information. PET is used in neurology and cardiology diseases. The National Center Cyclotron PET has been found to research, development and health science applications.

  7. Interests of the PET with 18-F.D.G. in infectious pathology: about a case of systemic candidiasis

    International Nuclear Information System (INIS)

    We report the interest of the PET with 18F-F.D.G. in the extension evaluation of injuries and in the therapy decision for a patient suffering of a systemic candida. Conclusions: In spite of a lack of recommendations, because of its great sensitivity for the deep infectious centres detection, the PET with 18F-F.D.G. can bring useful information to the management and follow up of the systemic infections. (N.C.)

  8. RPC PET: Status and perspectives

    Science.gov (United States)

    Couceiro, M.; Blanco, A.; Ferreira, Nuno C.; Ferreira Marques, R.; Fonte, P.; Lopes, L.

    2007-10-01

    The status of the resistive plate chamber (RPC)-PET technology for small animals is briefly reviewed and its sensitivity performance for human PET studied through Monte-Carlo simulations. The cost-effectiveness of these detectors and their very good timing characteristics open the possibility to build affordable Time of Flight (TOF)-PET systems with very large fields of view. Simulations suggest that the sensitivity of such systems for human whole-body screening, under reasonable assumptions, may exceed the present crystal-based PET technology by a factor up to 20.

  9. Extended suicide with a pet.

    Science.gov (United States)

    Cooke, Brian K

    2013-01-01

    The combination of the killing of a pet and a suicide is a perplexing scenario that is largely unexplored in the literature. Many forensic psychiatrists and psychologists may be unaccustomed to considering the significance of the killing of a pet. The subject is important, however, because many people regard their pets as members of their family. A case is presented of a woman who killed her pet dog and herself by carbon monoxide poisoning. The purpose of this article is to provide an initial exploration of the topic of extended suicide with a pet. Forensic mental health evaluations may have a role in understanding the etiology of this event and in opining as to the culpability of individuals who attempt to or successfully kill a pet and then commit suicide. Because the scientific literature is lacking, there is a need to understand this act from a variety of perspectives. First, a social and anthropological perspective will be presented that summarizes the history of the practice of killing of one's pet, with a focus on the ancient Egyptians. A clinical context will examine what relationship animals have to mental illness. A vast body of existing scientific data showing the relevance of human attachment to pets suggests that conclusions from the phenomena of homicide-suicide and filicide-suicide are applicable to extended suicide with a pet. Finally, recommendations will be proposed for both clinical and forensic psychiatrists faced with similar cases. PMID:24051598

  10. [The primary healthcare centres].

    Science.gov (United States)

    Brambilla, Antonio; Maciocco, Gavino

    2014-04-01

    The central attributes of primary care are: first contact (accessibility), longitudinality (person- focused preventive and curative care overtime), patient-oriented comprehensiveness and coordination (including navigation towards secondary and tertiary care). Besides taking care of the needs of the individuals, primary health care teams are also looking at the community, especially when addressing social determinants of health. The rationale for the benefits for primary care for health has been found in: 1) greater access to needed services; 2) better quality of care; 3) a greater focus on prevention; 4) early management of health problems; 5) organizing and delivering high quality care for chronic non-communicable diseases. This paper describes the role of primary healthcare centres in strengthening community primary services and in reducing health inequalities. Furthemore, the experiences of Regional Health Services from Tuscany and Emilia-Romagna are discussed, with a brief overview of the literature. PMID:24770539

  11. Exotic snakes are not always found in exotic places: how poison centres can assist emergency departments.

    Science.gov (United States)

    Lubich, Carol; Krenzelok, Edward P

    2007-11-01

    Emergency departments throughout the USA may have some familiarity with the management of envenomation from indigenous snake species such as Crotalinae (rattlesnakes) and Micrurus (coral snakes). However, venomous species may include exotic reptiles whose bites pose substantial treatment challenges due to both a lack of experience and the difficulty in obtaining antivenoms. Two pet cobra envenomation incidents illustrate the challenges that face emergency departments, especially in urban settings, that are confronted with these exposures. It is important for emergency departments to be aware of the large underground presence of exotic venomous reptile pets and to utilise the expertise of regional poison centres that will also assist in the procurement of exotic antivenoms.

  12. Experiences of Telebased Information Centres

    DEFF Research Database (Denmark)

    Falch, Morten

    1999-01-01

    Tele-based information community centres or just tele-centres have been seen as the killer application to empower local communities in developed and developing countries to meet the challenges of the information society. This paper will present a number of models for introducing such centres and ...... and discuss the different models and national strategies used for setting up tele-based information in relation to the Ghana experience.......Tele-based information community centres or just tele-centres have been seen as the killer application to empower local communities in developed and developing countries to meet the challenges of the information society. This paper will present a number of models for introducing such centres...

  13. Update on System Coordination Centre

    Energy Technology Data Exchange (ETDEWEB)

    Stangl, W. [Power Pool of Alberta, Calgary, AB (Canada)

    1998-07-01

    The new System Coordination Centre at the Power Pool of Alberta was designed to meet the unique requirements of Alberta`s electric industry under the new regulatory regime. Development of the Centre, key provisions of the energy management system (EMS) are highlighted. The centre will provide an energy management system for the Pool`s system controller function and interface with the Power Pool Administrator`s market functions and the operations of the Transmission Administrator. System controllers are expected to be operating from the new location by the end of 1998. Unique EMS features of the centre include: (1) real-time management of energy market and network operations using diverse SCADA/EMS, (2) inter-control centre protocol used to accommodate the unique participant information requirements, and (3) special custom applications. The Centre is expected to be fully functioning by July 1999. 1 fig.

  14. Cost-effectiveness of PET and PET/Computed Tomography

    DEFF Research Database (Denmark)

    Gerke, Oke; Hermansson, Ronnie; Hess, Søren;

    2015-01-01

    measure by means of incremental cost-effectiveness ratios when considering the replacement of the standard regimen by a new diagnostic procedure. This article discusses economic assessments of PET and PET/computed tomography reported until mid-July 2014. Forty-seven studies on cancer and noncancer...

  15. Post-target produced [{sup 18}F]F{sub 2} in the production of PET radiopharmaceuticals

    Energy Technology Data Exchange (ETDEWEB)

    Forsback, Sarita; Solin, Olof [Turku PET Centre, Turku (Finland). Radiopharmaceutical Chemistry Lab. and Accelerator Lab.

    2015-06-01

    Electrophilic radiofluorination was successfully carried out in the early years of PET radiochemistry due to its ease and fast reaction speed. However, at the present, the use of electrophilic methods is limited due to low specific activity (SA). Post-target produced [{sup 18}F]F{sub 2} has significantly higher SA compared to other electrophilic approaches, and it has been used in the production of clinical PET radiopharmaceuticals at the Turku PET Centre for years. Here, we summarize the synthesis and use of these radiopharmaceuticals, namely [{sup 18}F]FDOPA, [{sup 18}F] CFT, [{sup 18}F]EF5 and [{sup 18}F]FBPA.

  16. What PET is changing in follow-up of Hodgkin's disease and non Hodgkin's lymphoma?

    International Nuclear Information System (INIS)

    Positron emission tomography (PET) with 18-Fluoro-Deoxyglucose is a new imaging tool used to improve the initial extend and the follow-up of Hodgkin's disease and non Hodgkin's lymphoma. This functional imaging, in complement with morphological imaging, helps the clinicians to detect infra radiological disease and to fit therapy. Discordant results with different PET types were described in literature. Now, better results are obtained according to procedure guidelines from clinical indications to staff interpretation. Recently, PET/CT combines morphological and functional imaging to obtain less false negative and false positive findings. PET is useful in aggressive high grade lymphoma and in Hodgkin's disease from the initial staging to the final outcome: (a) PET detects more nodal and extra nodal lesions (b) PET is predictive of early and final response to therapy. PET can track early refractory disease -before grafting or at the end of proceedings- and allows to influence on patient management and improve survival of patients. TEP must be used and evaluated in larger multi-centre prospective studies with economics evaluation. (author)

  17. Mineral Physics Research on Earth's Core and UTeach Outreach Activities at UT Austin

    Science.gov (United States)

    Lin, J.; Wheat, A. J.

    2011-12-01

    Comprehension of the alloying effects of major candidate light elements on the phase diagram and elasticity of iron addresses pressing issues on the composition, thermal structures, and seismic features of the Earth's core. Integrating this mineral physics research with the educational objectives of the CAREER award was facilitated by collaboration with the University of Texas at Austin's premier teaching program, UTeach. The UTeach summer outreach program hosts three one-week summer camps every year exposing K-12th graders to university level academia, emphasizing math and science initiatives and research. Each week of the camp either focuses on math, chemistry, or geology. Many of the students were underrepresented minorities and some required simultaneous translation; this is an effect of the demographics of the region, and caused some language barrier challenges. The students' opportunity to see first-hand what it is like to be on a university campus, as well as being in a research environment, such as the mineral physics lab, helps them to visualize themselves in academia in the future. A collection of displayable materials with information about deep-Earth research were made available to participating students and teachers to disseminate accurate scientific knowledge and enthusiasm. These items included a diamond anvil cell and diagrams of the diamond crystal structure, the layers of the Earth, and the phases of carbon to show that one element can have very different physical properties purely based on differences in structure. The students learned how advanced X-ray and optical laser spectroscopies are used to study properties of planetary materials in the diamond anvil cell. Stress was greatly placed on the basic mathematical relationship between force, area, and pressure, the fundamental principle involved with diamond anvil cell research. Undergraduate researchers from the lab participated in the presentations and hands-on experiments, and answered any

  18. Geochemical Indicators of Urban Development in Tributaries and Springs along the Bull Creek Watershed, Austin, TX

    Science.gov (United States)

    Senison, J. J.; Banner, J. L.; Reyes, D.; Sharp, J. M.

    2012-12-01

    Urbanization can cause significant changes to both flow and water quality in streams and tributaries. In the Austin, Texas, area, previous studies have demonstrated that streamwater strontium isotope compositions (87Sr/86Sr) correlate with measures of urbanization when comparing non-urbanized streams to their urban counterparts. The inclusion of municipal water into natural surface water is inferred from the mean 87Sr/86Sr value found in urbanized streams, which falls between the high value in treated municipal water and the lower values found in local surface streams sourcing from non-urbanized catchments. Fluoride is added to municipal tap water in the treatment process, and a correlation between 87Sr/86Sr and fluoride is observed in streamwater sampled from the watersheds around Austin. These relationships represent some of the principal findings reported in Christian et al. (2011). Current research is testing the hypothesis that municipal water influx in urban areas is a primary modifier of stream- and spring-water chemistry in a single watershed that contains a strong gradient in land use. We compare 87Sr/86Sr and other chemical constituents with potential contributing endmembers, such as municipal tap water and wastewater, local soil and rock leachates, and land use within the Bull Creek watershed. As a consequence of the history of land development, some Bull Creek tributaries are sourced and flow almost entirely in fully-developed areas, whereas others are located in protected natural areas. Thirteen tributaries were monitored and classified as either urbanized or non-urbanized based upon land use within the tributary catchment. Springs in the Bull Creek watershed were also sampled and are similarly classified. The Bull Creek watershed is composed of Lower Cretaceous limestone with significantly lower 87Sr/86Sr than that of municipal water taken from the Lower Colorado River, which is underlain in part by Precambrian rocks upstream of Austin. There are

  19. Neurotransmission imaging by PET

    Energy Technology Data Exchange (ETDEWEB)

    Takano, Akihiro; Suhara, Tetsuya [National Inst. of Radiological Sciences, Chiba (Japan)

    2001-08-01

    PET studies on neurotransmission in psychological disorders to evaluate abnormal neurotransmission and therapeutic effects are thoroughly reviewed by type of major neurotransmitters. Studies on dopaminergic neurotransmission have focused on the function of dopamine D{sub 2} receptors, receptor subtypes, such as the D{sub 1} receptor, and ligands, such as transporters. PET studies of dopamine D{sub 2} receptor, which began in the early 1980s, have predominantly been performed in schizophrenia, and most have failed to detect any statistically significant differences between schizophrenia patients and controls. The studies in the early 1980s were performed by using [{sup 11}C]N-methyl-spiperone (NMSP) and [{sup 11}C]raclopride, ligands for striatal dopamine D{sub 2} receptors. [{sup 11}C]FLB457, which has much higher affinity for D{sub 2} receptors than raclopride, began to be used in the 1990s. Dopamine D{sub 2} occupancy after drug ingestion has also been investigated to clarify the mechanisms and effects of antipsychotic drugs, and there have also been studies on the effect of aging and personality traits on dopamine D{sub 2} receptor levels in healthy subjects. In studies on dopamine receptor subtypes other than D{sub 2}, dopamine D{sub 1} receptors have been studied in connection with assessments of cognitive functions. Most studies on dopamine transporters have been related to drug dependence. Serotonin 5-HT{sub 2A} receptors have been studied with [{sup 11}C]NMSP in schizophrenia patients, while studies of another serotonin receptor subtype, 5-HT{sub 1A} receptors, have been mainly conducted in patients with depression. [{sup 11}C]NMSP PET showed no difference between schizophrenia patients who had not undergone phamacotherapy and normal subjects. Because serotonin selective reuptake inhibitors (SSRIs) affect serotonin transporters, and abnormalities in serotonin transporters detected in mood disorders, PET ligands for serotonin transporters have increasingly

  20. Get Set for a Pet.

    Science.gov (United States)

    DeRosa, Bill

    1987-01-01

    Describes a game in which students deal with some of the factors involved in being a responsible pet owner. Includes a list of the materials needed for the game and provides the game board and the game pieces, along with a fold-out poster about neutering and spaying pets. (TW)

  1. Welfare assessment in pet rabbits

    NARCIS (Netherlands)

    Schepers, F.; Koene, P.; Beerda, B.

    2009-01-01

    One million pet rabbits are kept in The Netherlands, but there are no data available on their behaviour and welfare. This study seeks to assess the welfare of pet rabbits in Dutch households and is a first step in the development of a welfare assessment system. In an internet survey, housing systems

  2. Narrating the Racialization of Space in Austin, Texas and Nashville, Tennessee

    Directory of Open Access Journals (Sweden)

    Martha Norkunas

    2015-12-01

    Full Text Available Narrating the Racialization of Space in Austin, Texas and Nashville, Tennessee People of color in the United States have been obligated to move through public space in particular ways, dictated by law and social custom. Narrators create cognitive maps of movement in the city shaped by racial codes of behavior. The maps change over time as law and social custom changes. The fluidity of the maps is also influenced by status, gender, class, and skin tone. This paper examines a rich body of oral narratives co-created with African Americans from 2004 to 2014 focusing on how men and women narrate their concepts of racialized space. It moves from narratives about the larger landscape — the city — to smaller, more personal public places — the sidewalk and the store — to intimate sites of contact in the public sphere. Many of the narratives describe complex flows of controlled movement dictated by racial boundaries in the context of capitalism. The narratives form an urban ethnography of the power relations inscribed on the landscape by racializing movement in space.   Narracje o urasowieniu przestrzeni w Austin (Teksas i Nashville (Tennessee Nie-Biali w Stanach Zjednoczonych byli zmuszeni do poruszania się w przestrzeni publicznej w szczególny sposób, określony przez prawo i zwyczaj społeczny. W swoich narracjach badani tworzą mapy kognitywne ruchu w mieście, kształtowane przez rasowe kody zachowania. Mapy te zmieniały się w czasie pod wpływem zmian prawnych i zwyczajowych. Na płynność tych map wpływały także status, płeć, klasa i odcień koloru skóry. W artykule przeanalizowano bogaty zbiór relacji ustnych tak zwanych Afroamerykanów, zbieranych w latach 2004-2014; uwaga skupia się na tym, jak mężczyźni i kobiety opowiadają o swoim widzeniu przestrzeni urasowionej. Omówiono narracje o szerszej przestrzeni miasta, jak i węższej, skoncentrowanej na bardziej osobistych miejscach publicznych, takich jak sklep. Wiele

  3. Austin's Home Performance with Energy Star Program: Making a Compelling Offer to a Financial Institution Partner

    Energy Technology Data Exchange (ETDEWEB)

    Zimring, Mark

    2011-03-18

    Launched in 2006, over 8,700 residential energy upgrades have been completed through Austin Energy's Home Performance with Energy Star (HPwES) program. The program's lending partner, Velocity Credit Union (VCU) has originated almost 1,800 loans, totaling approximately $12.5 million. Residential energy efficiency loans are typically small, and expensive to originate and service relative to larger financing products. National lenders have been hesitant to deliver attractive loan products to this small, but growing, residential market. In response, energy efficiency programs have found ways to partner with local and regional banks, credit unions, community development finance institutions (CDFIs) and co-ops to deliver energy efficiency financing to homeowners. VCU's experience with the Austin Energy HPwES program highlights the potential benefits of energy efficiency programs to a lending partner.

  4. Council celebrates CERN Control Centre

    CERN Multimedia

    2006-01-01

    With the unveiling of its new sign, the CERN Control Centre was officially inaugurated on Thursday 16 March. To celebrate its startup, CERN Council members visited the sleek centre, a futuristic-looking room filled with a multitude of monitoring screens.

  5. Standard Operating Procedures for PET/CT: A Practical Approach for Use in Adult Oncology

    International Nuclear Information System (INIS)

    Over the past 20 years, positron emission tomography (PET) and PET/CT (computed tomography) have revolutionized the care of cancer patients in developed countries and are increasingly being adopted in emerging economies. PET has been, and still is, one of the fastest growing fields in medical imaging. There are several reasons for the rapid development of this imaging technology. As the populations of many countries continue to age, cancer constitutes a major health problem, with increasing incidence worldwide. In developed countries where heart disease is the primary cause of mortality, cancer is a close second and may eventually overtake it. Proper cancer management requires highly accurate imaging to characterize, stage, restage, assess response to therapy, prognosticate and detect recurrence. Such information is critical in a disease that often requires the correct initial treatment in order to improve the chance of successfully curing the patient. The ability to provide, in a single imaging session, detailed anatomical and metabolic/functional information, which has a powerful synergistic effect that is greater than the sum of the two individual techniques, has established PET/CT as an indispensable imaging procedure in the management of many different types of cancer. The quality and reliability of the images acquired on a PET/CT scanner depend on the quality of the imaging technique. This publication addresses this important aspect of PET/CT imaging, namely, how to perform an 18F-fluorodeoxyglucose (FDG) PET/CT scan in an adult patient with cancer. Although there are several publications and guidelines on different protocols for PET/CT imaging using FDG, the aim here is to provide a comprehensive overview that can be used both by new PET/CT centres in the process of starting up and by established imaging centres for updating older protocols. Written by experts from several continents, the book provides an up to date, evidence based and comprehensive overview

  6. Non FDG PET

    Energy Technology Data Exchange (ETDEWEB)

    Nanni, C., E-mail: cristina.nanni@aosp.bo.i [Nuclear Medicine Unit, Policlinico S.Orsola, University of Bologna, Bologna (Italy); Fantini, L.; Nicolini, S.; Fanti, S. [Nuclear Medicine Unit, Policlinico S.Orsola, University of Bologna, Bologna (Italy)

    2010-07-15

    2- [{sup 18}F]-fluoro-2-deoxy-D-glucose (FDG) is the radiopharmaceutical most frequently used for clinical positron emission tomography (PET). However, FDG cannot be used for many oncological, cardiological, or neurological conditions, either because the abnormal tissue does not concentrate it, or because the tissues under investigation demonstrate high physiological glucose uptake. Consequently, alternative PET tracers have been produced and introduced into clinical practice. The most important compounds in routine practice are {sup 11}C-choline and {sup 18}F-choline, mainly for the evaluation of prostate cancer; {sup 1}C-methionine for brain tumours; {sup 118}F-DOPA ({sup 18}F- deoxiphenilalanine) for neuroendocrine tumours and movement disorders; {sup 68}Ga-DOTANOC (tetraazacyclododecanetetraacetic acid-[1-Nal3]-octreotide) and other somatostatin analogues for neuroendocrine tumours; 11C-acetate for prostate cancer and hepatic masses and 18F-FLT (3'-deoxy-3'-fluorothymidine) for a number of malignant tumours. Another impetus for the development of new tracers is to enable the investigation of biological processes in tumours other than glucose metabolism. This is especially important in the field of response assessment, where there are new agents that are targeted more specifically at angiogenesis, hypoxia, apoptosis and other processes.

  7. Neuropsychiatry: PET and SPECT

    International Nuclear Information System (INIS)

    Functional brain imaging with PET and SPECT have a definitive and well established role in the investigation of a variety of conditions such as dementia, epilepsy and drug addiction. With these methods it is possible to detect early rCBF (regional Cerebral Blood Flow) changes seen in dementia (even before clinical symptoms) and differentiate Alzheimer's disease from other dementias by means of the rCBF pattern change. 18-F-FDG PET imaging is a useful tool in partial epilepsy because both rCBF and brain metabolism are compromised at the epileptogenic focus. During the seizure, rCBF dramatically increases locally. Using SPECT it is possible to locate such foci with 97% accuracy. In drug addiction, particularly with cocaine, functional imaging has proven to be very sensitive to detect brain flow and metabolism derangement early in the course of this condition. These findings are important in many ways: prognostic value, they are used as a powerful reinforcement tool and to monitor functional recovery with rehabilitation. There are many other conditions in which functional brain imaging is of importance such as acute stroke treatment assessment, trauma rehabilitation and in psychiatric and abnormal movement diseases specially with the development of receptor imaging (au)

  8. FDG PET imaging dementia

    International Nuclear Information System (INIS)

    Dementia is a major burden for many countries including South Korea, where life expectancy is continuously growing and the proportion of aged people is rapidly growing. Neurodegenerative disorders, such as, Alzheimer disease, dementia with Lewy bodies, frontotemporal dementia. Parkinson disease, progressive supranuclear palsy, corticobasal degeneration, Huntington disease, can cause dementia, and cerebrovascular disease also can cause dementia. Depression or hypothyroidism also can cause cognitive deficits, but they are reversible by management of underlying cause unlike the forementioned dementias. Therefore these are called pseudodementia. We are entering an era of dementia care that will be based upon the identification of potentially modifiable risk factors and early disease markers, and the application of new drugs postpone progression of dementias or target specific proteins that cause dementia. Efficient pharmacologic treatment of dementia needs not only to distinguish underlying causes of dementia but also to be installed as soon as possible. Therefore, differential diagnosis and early diagnosis of dementia are utmost importance. F-18 FDG PET is useful for clarifying dementing diseases and is also useful for early detection of the disease. Purpose of this article is to review the current value of FDG PET for dementing diseases including differential diagnosis of dementia and prediction of evolving dementia

  9. FDG PET imaging dementia

    Energy Technology Data Exchange (ETDEWEB)

    Ahn, Byeong Cheol [Kyungpook National University Medical School and Kyungpook National University Hospital, Daegu (Korea, Republic of)

    2007-04-15

    Dementia is a major burden for many countries including South Korea, where life expectancy is continuously growing and the proportion of aged people is rapidly growing. Neurodegenerative disorders, such as, Alzheimer disease, dementia with Lewy bodies, frontotemporal dementia. Parkinson disease, progressive supranuclear palsy, corticobasal degeneration, Huntington disease, can cause dementia, and cerebrovascular disease also can cause dementia. Depression or hypothyroidism also can cause cognitive deficits, but they are reversible by management of underlying cause unlike the forementioned dementias. Therefore these are called pseudodementia. We are entering an era of dementia care that will be based upon the identification of potentially modifiable risk factors and early disease markers, and the application of new drugs postpone progression of dementias or target specific proteins that cause dementia. Efficient pharmacologic treatment of dementia needs not only to distinguish underlying causes of dementia but also to be installed as soon as possible. Therefore, differential diagnosis and early diagnosis of dementia are utmost importance. F-18 FDG PET is useful for clarifying dementing diseases and is also useful for early detection of the disease. Purpose of this article is to review the current value of FDG PET for dementing diseases including differential diagnosis of dementia and prediction of evolving dementia.

  10. Edwin Austin Abbey's The Passage of the Hours: Astronomy as History

    Science.gov (United States)

    Ricci, P. L.

    2016-01-01

    The Passage of the Hours (1909-1911) in the Pennsylvania State Capitol at Harrisburg is one of the most original and least known astronomical ceilings in the United States. Designed by the American artist Edwin Austin Abbey (1852-1911) to complement the Italian Renaissance style architecture of the House of Representatives, the mural combines two classical traditions of representing the night sky: a celestial map with the constellations of the zodiac and the personifications of the Hours. Set in a shallow dome twenty-four feet in diameter, Abbey's constellation figures float in a dazzling firmament where the Milky Way streams between the Sun and the Moon. The artist placed the Horae of Greek mythology around the dome's circumference in the position of the numbers on an astronomical clock. In the tradition of Italian Renaissance architecture, the celestial ceiling in the House of Representatives was part of an iconographic program affirming the cosmological origin of a polity. The astronomical theme relates to Abbey's murals in the House Chamber of the first public reading of the Declaration of Independence in 1776 from David Rittenhouse's observatory in Philadelphia, which the astronomer constructed to study the transit of Venus in 1769. The artist included a portrait of Rittenhouse holding his telescope among the worthies in the adjacent mural of The Apotheosis of Pennsylvania. Contemporary as well as historical events encouraged Abbey's use of astronomical imagery: the depiction of a comet may record the much-anticipated return of Halley's Comet in 1910.

  11. Plasma armature railgun launcher simulations at the Univ. of Texas at Austin

    International Nuclear Information System (INIS)

    The Center for Electromechanics at the University of Texas at Austin (CEM-UT) has developed, while performing research associated with several Defense Advanced Research Projects Agency (DARPA) contracts, a velocity dependent friction model that accurately predicts the losses associated with a plasma armature railgun. Test results from CEM-UT's 1 m long, 1.27 cm square bore, plasma-armature railgun have been used to determine the validity of the model. Deviation between calculated and measured performance is typically less than 5% at railgun currents below 500 kA, however, at currents greater than 500 kA, the deviation increases. Experimental evidence suggests that the railguns lack of stiffness and subsequent venting of driving pressure rather than the electromechanical model is primarily responsible for the divergence between predicted and measured results. To test this theory a railgun was built using external preloading rings (Ringfeder) to increase its stiffness. On the first test of the Ringfeder railgun, 625 kA was discharged into the gun and the projectile was accelerated to 5.9 km/s. Test data indicates that the projectile accelerated through the entire length of the railgun and that a minimum amount of plasma leakage occurred during the test. An analysis of the 625-kA test was done to compare the results of CEM-UT's frictional loss model to ablation and viscous drag loss models

  12. UTeach: Secondary Teacher Preparation in Science and Mathematics at the University of Texas at Austin

    Science.gov (United States)

    Marder, Michael

    2006-03-01

    The UTeach Program is a joint effort of the College of Natural Sciences, the College of Education and the Austin Independent School District to recruit, prepare and support math and science teachers for the State of Texas. UTeach uses early and on-going field experiences to capture the imagination of preservice teachers and provide a foundation for more advanced pedagogical courses. With over 400 students enrolled and over 80 graduates per year, UTeach is one of the largest programs producing secondary science, mathematics, and computer science teachers in the nation. Most UTeach students are undergraduates, but around 10% are people of many ages with strong backgrounds in mathematics or science who have decided to enter teaching. Hallmarks include: *Four-year degree plans that enable undergraduates to obtain certification at no cost in time or money. *Active recruitment and support including tuition reimbursement, paid internships, personal advising, and guidance by master teachers. *Emphasis on preparing teachers who will be knowledgeable of their discipline, experienced with involving students in scientific inquiry, and practiced in employing new technologies to enhance student learning. *A revised, streamlined professional education sequence drawing on research on learning, standards-based curricula, multiple forms of assessment, and proven strategies for achieving equity and integrating technology into math and science education. *Program flexibility with multiple entry points (from freshman to post baccalaureate), integrated degree plans, and proficiency-based assessment, including the development of individual teaching portfolios. For more information on UTeach, see http://uteach.utexas.edu

  13. Chronic aluminum intake causes Alzheimer's disease: applying Sir Austin Bradford Hill's causality criteria.

    Science.gov (United States)

    Walton, J R

    2014-01-01

    Industrialized societies produce many convenience foods with aluminum additives that enhance various food properties and use alum (aluminum sulfate or aluminum potassium sulfate) in water treatment to enable delivery of large volumes of drinking water to millions of urban consumers. The present causality analysis evaluates the extent to which the routine, life-long intake, and metabolism of aluminum compounds can account for Alzheimer's disease (AD), using Austin Bradford Hill's nine epidemiological and experimental causality criteria, including strength of the relationship, consistency, specificity, temporality, dose-dependent response, biological rationale, coherence with existing knowledge, experimental evidence, and analogy. Mechanisms that underlie the risk of low concentrations of aluminum relate to (1) aluminum's absorption rates, allowing the impression that aluminum is safe to ingest and as an additive in food and drinking water treatment, (2) aluminum's slow progressive uptake into the brain over a long prodromal phase, and (3) aluminum's similarity to iron, in terms of ionic size, allows aluminum to use iron-evolved mechanisms to enter the highly-active, iron-dependent cells responsible for memory processing. Aluminum particularly accumulates in these iron-dependent cells to toxic levels, dysregulating iron homeostasis and causing microtubule depletion, eventually producing changes that result in disconnection of neuronal afferents and efferents, loss of function and regional atrophy consistent with MRI findings in AD brains. AD is a human form of chronic aluminum neurotoxicity. The causality analysis demonstrates that chronic aluminum intake causes AD.

  14. PET-Based Thoracic Radiation Oncology.

    Science.gov (United States)

    Simone, Charles B; Houshmand, Sina; Kalbasi, Anusha; Salavati, Ali; Alavi, Abass

    2016-07-01

    Fluorodeoxyglucose-PET is increasingly being integrated into multiple aspects of oncology. PET/computed tomography (PET/CT) has become especially important in radiation oncology. With the increasing use of advanced techniques like intensity-modulated radiation therapy and proton therapy, PET/CT scans have played critical roles in the target delineation of tumors for radiation oncologists delivering conformal treatment techniques. Use of PET/CT is well established in lung cancer and several other thoracic malignancies. This article details the current uses of PET/CT in thoracic radiation oncology with a focus on lung cancer and describes expected future roles of PET/CT for thoracic tumors.

  15. Utility of PET in unknown primary with cervical metastasis: A retrospective study

    Directory of Open Access Journals (Sweden)

    M R Dandekar

    2011-01-01

    Full Text Available Background: FDG-PET is recommended as an investigation in unknown primary tumors, but its definitive role and cost effectiveness are yet to be established. Aims: dditional value of FDG-PET over conventional imaging in unknown primary tumors with cervical metastasis. Setting and Design: Retrospective study in a tertiary level oncology centre. Materials and Methods: A total of 112 patients were divided into three groups; 53 with conventional modalities (either computed tomography or magnetic resonance imaging (group I, 59 with FDG-PET (group II, and group III (subgroup of group II with both (40 patients. Statistical Analysis: Sensitivity and specificity of both conventional modality and PET were calculated. Association between neck nodes and distant metastasis was analysed using multivariate logistic regression analysis. Results: Sensitivity and specificity for conventional modalities was 92.3% and 50% and sensitivity and specificity of FDG-PET was 92.8% and 71.4%, respectively. FDG-PET detected metastasis in 52.54% of patients. Multivariate logistic regression analysis showed statistically significant association between distant metastasis and multiplicity of nodes (N2b, N2c (P = 0.007. Among all patients with low neck nodes in group II, FDG-PET detected primaries in 12 patients, 9 of which were infraclavicular (75%. FDG-PET added information to conventional imaging in 32.5% of patients and influenced an overall change in management in 38.9% of patients. Conclusions: FDG-PET is a valuable tool influencing change of management in unknown primary with cervical metastasis. It is recommended especially in the presence of low or multiple neck nodes in view of high incidence of infraclavicular primary and distant metastasis, respectively.

  16. Protocol requirements and diagnostic value of PET/MR imaging for liver metastasis detection

    Energy Technology Data Exchange (ETDEWEB)

    Reiner, Caecilia S. [University Hospital Zurich, Diagnostic and Interventional Radiology, Zurich (Switzerland); Stolzmann, Paul [University Hospital Zurich, Diagnostic and Interventional Radiology, Zurich (Switzerland); University Hospital Zurich, Nuclear Medicine, Zurich (Switzerland); University Hospital Zurich, Division of Nuclear Medicine, Zurich (Switzerland); Husmann, Lars; Burger, Irene A.; Huellner, Martin W.; Schulthess, Gustav K. von [University Hospital Zurich, Nuclear Medicine, Zurich (Switzerland); Schaefer, Niklaus G. [University Hospital Zurich, Nuclear Medicine, Zurich (Switzerland); University Hospital Zurich, Oncology, Zurich (Switzerland); Schneider, Paul M. [University Hospital Zurich, Visceral and Transplant Surgery, Zurich (Switzerland); Veit-Haibach, Patrick [University Hospital Zurich, Diagnostic and Interventional Radiology, Zurich (Switzerland); University Hospital Zurich, Nuclear Medicine, Zurich (Switzerland)

    2014-04-15

    To compare the accuracy of PET/MR imaging with that of FDG PET/CT and to determine the MR sequences necessary for the detection of liver metastasis using a trimodality PET/CT/MR set-up. Included in this single-centre IRB-approved study were 55 patients (22 women, age 61 ± 11 years) with suspected liver metastases from gastrointestinal cancer. Imaging using a trimodality PET/CT/MR set-up (time-of-flight PET/CT and 3-T whole-body MR imager) comprised PET, low-dose CT, contrast-enhanced (CE) CT of the abdomen, and MR with T1-W/T2-W, diffusion-weighted (DWI), and dynamic CE imaging. Two readers evaluated the following image sets for liver metastasis: PET/CT (set A), PET/CECT (B), PET/MR including T1-W/T2-W (C), T1-W/T2-W with either DWI (D) or CE imaging (E), and a combination (F). The accuracy of each image set was determined by receiver-operating characteristic analysis using image set B as the standard of reference. Of 120 liver lesions in 21/55 patients (38 %), 79 (66 %) were considered malignant, and 63/79 (80 %) showed abnormal FDG uptake. Accuracies were 0.937 (95 % CI 89.5 - 97.9 %) for image set A, 1.00 (95 % CI 99.9 - 100.0 %) for set C, 0.998 (95 % CI 99.4 - 100.0 %) for set D, 0.997 (95 % CI 99.3 - 100.0 %) for set E, and 0.995 (95 % CI 99.0 - 100.0 %) for set F. Differences were significant for image sets D - F (P < 0.05) when including lesions without abnormal FDG uptake. As shown by follow-up imaging after 50 - 177 days, the use of image sets D and both sets E and F led to the detection of metastases in one and three patients, respectively, and further metastases in the contralateral lobe in two patients negative on PET/CECT (P = 0.06). PET/MR imaging with T1-W/T2-W sequences results in similar diagnostic accuracy for the detection of liver metastases to PET/CECT. To significantly improve the characterization of liver lesions, we recommend the use of dynamic CE imaging sequences. PET/MR imaging has a diagnostic impact on clinical decision making. (orig.)

  17. Toxicity and Long-Term Outcomes of Dose-Escalated Intensity Modulated Radiation Therapy to 74Gy for Localised Prostate Cancer in a Single Australian Centre

    OpenAIRE

    Vincent Khoo; Maureen Rolfo; Nigel Anderson; Morikatsu Wada; Aldo Rolfo; George Quong; Carmel Mantle; Angela Viotto; Joseph Sia; Daryl Lim Joon

    2011-01-01

    Purpose: To report the toxicity and long-term outcomes of dose-escalated intensity-modulated radiation therapy (IMRT) for patients with localised prostate cancer. Methods and Materials: From 2001 to 2005, a total of 125 patients with histologically confirmed T1-3N0M0 prostate cancer were treated with IMRT to 74Gy at the Austin Health Radiation Oncology Centre. The median follow-up was 5.5 years (range 0.5–8.9 years). Biochemical prostate specific antigen (bPSA) failure was defined according t...

  18. PET i prekirurgisk evaluering av epilepsi

    OpenAIRE

    2010-01-01

    PET in presurgical evaluation of epilepsy. Background: Today, at Rikshospitalet PET medical center, FDG is used as a tracer in the PET investigations during the presurgical evaluation of patients with epilepsy. The purpose of this paper is to see if FGD-PET gives additional information compared with EEG and MR. Another purpose was to find out whether there is a need for new ligands, and which ones. Material and methods: All epilepsy order forms to FDG-PET at Rikshopitalet, during 2007...

  19. Scintillation crystals required for PET

    International Nuclear Information System (INIS)

    In PET, inorganic scintillator crystals are used to record γ rays produced by the annihilation of positrons emitted by injected tracers. The ultimate performance of the camera is strongly tied to both the physical and scintillation properties of the crystals. For this reason, researchers have investigated virtually all known scintillator crystals for possible use in PET. Despite this massive research effort, only a few different scintillators have been found that have a suitable use. Two recently developed scintillator crystals (LSO and GSO), appears to surpass all previously used materials in most respects and promises to be the basis for the next generation of PET cameras. (authors)

  20. The Aube centre; Le Centre de l`Aube

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-07-01

    This educational booklet is devoted to a general presentation of the Aube radioactive wastes storage centre. After a short presentation of the Andra, the French national agency for the management of radioactive wastes, it gives some general information about radioactive wastes (origin, classification), containers (quality assurance and different types), wastes transportation (planning, safety), and about the Aube centre itself: description, treatment and conditioning of drums (compacting and injection), storage facilities, geological situation of the site, and environmental controls. (J.S.)

  1. PET and PET/CT in tumour of undetermined origin

    International Nuclear Information System (INIS)

    In this presentation the following conclusions were obtained regarding the use of PET and PET/CT in patient with cancer of unknown primary: 1. Detection of the primary one in 1/3 at 1/2 of patient. 2. It detects metastases in other places in 50%. 3. It changes the initial therapy planned in 1/3 at 1/2 of patient. 4. Useful in initial phases of protocol study to limit the other procedures. After standard evaluation. Before advanced protocol. 5. PET/CT study increases the % of primary detection, although in a non significant way vs. PET. 6. They are required more studies to value their utility to a more objective manner. (Author)

  2. PET/TAC in Oncology; PET/TAC en Oncologia

    Energy Technology Data Exchange (ETDEWEB)

    Jimenez V, A.M. [Especialista en Medicina Nuclear, Profa. Depto. Radiologia de la Facultad de Medicina, Universidad Complutense de Madrid, Madrid (Spain)

    2007-07-01

    From this presentation of PET-TAC in oncology the following advantages on the conventional PET are obtained: 1. More short study and stadium in one session. 2. It adds the information of both techniques. 3. Better localization of leisure: affected organ, stadium change (neck, mediastinum, abdomen). 4. Reduction of false positive (muscle, brown fat, atelectasis, pneumonias, intestine, urinary vials, etc.). 5. Reduction of negative false. 6. Reduction of not conclusive. 7. More understandable for other specialists. 8. Biopsies guide. 9. Planning radiotherapy.

  3. 10 "Poison Pills" for Pets

    Science.gov (United States)

    ... Care Animal Welfare Veterinary Careers Public Health 10 "Poison Pills" for Pets Anyone who takes medication prescribed ... of all phone calls to the ASPCA Animal Poison Control Center (APCC) are about human medications. Your ...

  4. Pets and the immunocompromised person

    Science.gov (United States)

    ... affect the cat's immune system. This puts your cat at risk of other infections that may be spread to humans. Feed your pet only commercially prepared food and treats. Animals can get sick from undercooked ...

  5. Disaster Preparedness for Your Pet

    Science.gov (United States)

    ... Do not let your pet interact with other animals Use disinfectant to clean the cage and litter box Leptospirosis is a bacterial disease found in the urine of infected animals that can cause kidney damage and affect other ...

  6. Innovations in PET/CT

    DEFF Research Database (Denmark)

    Levin Klausen, T; Høgild Keller, S; Vinter Olesen, O;

    2012-01-01

    impressive anatomical details. PET/CT designs are facing many challenges such as the conversion of CT numbers to attenuation coefficients, giving rise to artefacts due to the presence of high Zeff material. Patient motion during scans degrades image quality and subsequent analysis, and is a challenge......There has been a longstanding interest in positron emission tomography (PET) in combination with computed tomography (CT). Mostly because of the lack of structural information in PET which makes it difficult to assess the precise location of tissue with metabolic uptake, whereas CT can provide...... especially as spatial resolution improves. Software based image fusion remains a complex issue outside the brain. State of the art image quality in a modern PET/CT system includes incorporation of point spread function (PSF) and time-of-flight (TOF) information into the reconstruction leading to the high...

  7. Selecting Safe Pets (For Parents)

    Science.gov (United States)

    ... Reports? What to Say Vaccines: Which Ones & When? Smart School Lunches Emmy-Nominated Video "Cerebral Palsy: Shannon's ... pets. If you're interested in rabbits, the House Rabbit Society is an excellent resource — visit its ...

  8. Preventing Ticks on Your Pets

    Science.gov (United States)

    ... Tickborne diseases abroad Borrelia miyamotoi Borrelia mayonii Preventing ticks on your pets Recommend on Facebook Tweet Share ... your cats without first consulting your veterinarian! Kill Ticks on Dogs A pesticide product that kills ticks ...

  9. PET/CT and PET - application in pediatric oncology; PET/CT und PET - Einsatz in der paediatrischen Onkologie

    Energy Technology Data Exchange (ETDEWEB)

    Franzius, C.; Lang, K.; Schober, O. [Klinik und Poliklinik fuer Nuklearmedizin, Univ. Muenster (Germany); Wormanns, D. [Inst. fuer klinische Radiologie, Univ. Muenster (Germany); Vormoor, J. [Klinik und Poliklinik fuer Kinder- und Jugendmedizin - Paediatrische Haematologie und Onkologie, Univ. Muenster (Germany)

    2004-12-01

    PET-CT is a new imaging technology with a high capability to improve oncologic imaging. Introduction into clinical practise started approximately 3 years ago. Consequently, the available literature data are preliminary. There are no studies concerning PET-CT in pediatric patients. Nevertheless, it can already be supposed that the synthesis of structural and metabolic information improves the accuracy of staging and has the realistic potential to change patient management in a relevant percentage rate in pediatric patients. In this article, the advantages and special features of the application of PET-CT in young oncologic patients are pointed out. Potential clinical applications of PET-CT in this patient group include Hodgkin and non-Hodgkin lymphomas, Ewing tumors, osteosarcomas, rhabdomyosarcomas and neuroblastomas. (orig.)

  10. PET and PET/CT in tumour of undetermined origin; PET y PET/CT en tumor de origen indeterminado

    Energy Technology Data Exchange (ETDEWEB)

    Garcia O, J.R. [Nuclear Medicine and Molecular Imaging, PET/CT, Centro Medico ABC, Mexico D.F. (Mexico)

    2007-07-01

    In this presentation the following conclusions were obtained regarding the use of PET and PET/CT in patient with cancer of unknown primary: 1. Detection of the primary one in 1/3 at 1/2 of patient. 2. It detects metastases in other places in 50%. 3. It changes the initial therapy planned in 1/3 at 1/2 of patient. 4. Useful in initial phases of protocol study to limit the other procedures. After standard evaluation. Before advanced protocol. 5. PET/CT study increases the % of primary detection, although in a non significant way vs. PET. 6. They are required more studies to value their utility to a more objective manner. (Author)

  11. Contemporary design for 'landmark' centre.

    Science.gov (United States)

    2009-08-01

    As one of the UK's largest builders of healthcare facilities, construction company Morgan Ashurst is accustomed to delivering complex, challenging hospital projects. The construction of a new oncology centre at Musgrove Park Hospital, Taunton for Taunton and Somerset NHS Foundation Trust-- said to be the first new stand-alone radiotherapy centre to be built in the UK for almost 20 years--was no exception. Health Estate Journal reports. PMID:19711668

  12. The centre of the action

    CERN Document Server

    2008-01-01

    The CERN Control Centre (CCC) has all the ingredients of an action movie control room: hundreds of screens, technicians buzzing in and out, huge floor-to-ceiling windows revealing the looming vista of a mountain range, flashing lights, microphones… This is the place where not just the LHC, but the whole of CERN’s accelerator complex and technical support is based - truly the centre of the action at CERN.

  13. PET imaging clinical trials: standards for good image quality

    International Nuclear Information System (INIS)

    restricted to FDG PET-CT imaging, but look forward towards development and application of new PET radiopharmaceuticals. An example of one of these novel radiopharmaceuticals is (18F) fluciclatide, which detects angiogenesis via the expression of αvβ3 integrins. Phase 2 global multi-centre studies are current underway evaluating this radiopharmaceutical and two clinical trial sites in Bangalore, India will commence recruitment in the near future. Clinical trial data from these studies will be presented to highlight the need for good image quality in clinical trials

  14. Training centres - organization and management

    International Nuclear Information System (INIS)

    In the lecture 'Training centres - organization and management' some principles and requirements which influence the organization, management and activity pattern of nuclear training centres, are briefly introduced. It is demonstrated, step by step, how these general principles are implemented in the development of the Czechoslovak nuclear power programme, it means, how the training of the NPP personnel proceeds in Czechoslovak nuclear training centres. General principles which are selected: a connection between the capacity of the training centre and the scope and needs of the nuclear power programme, a position of the training center within the institutional set-up, a structure and organization of the training system which complies with the system of NPP construction, reflect the pattern and the activity of the nuclear training centre and nuclear power technical level, a research group of workers in the nuclear training centre, main tasks and technical facilities, management of the training process and a transfer of knowledge and research results into the training process. The lecture is supplemented by pictures and slides. (orig.)

  15. PET/TAC in Oncology

    International Nuclear Information System (INIS)

    From this presentation of PET-TAC in oncology the following advantages on the conventional PET are obtained: 1. More short study and stadium in one session. 2. It adds the information of both techniques. 3. Better localization of leisure: affected organ, stadium change (neck, mediastinum, abdomen). 4. Reduction of false positive (muscle, brown fat, atelectasis, pneumonias, intestine, urinary vials, etc.). 5. Reduction of negative false. 6. Reduction of not conclusive. 7. More understandable for other specialists. 8. Biopsies guide. 9. Planning radiotherapy

  16. City of Austin: Green habitat learning project. A green builder model home project

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-12-01

    The purpose of the Year 14 UCETF project was to design and construct a residential structure that could serve as a demonstration facility, training site, and testing and monitoring laboratory for issues related to the implementation of sustainable building practices and materials. The Model Home Project builds on the previous and existing efforts, partially funded by the UCETF, of the City of Austin Green Builder Program to incorporate sustainable building practices into mainstream building activities. The Green Builder Program uses the term {open_quotes}green{close_quotes} as a synonym for sustainability. In the research and analysis that was completed for our earlier reports in Years 12 and 13, we characterized specific elements that we associate with sustainability and, thus, green building. In general, we refer to a modified life cycle assessment to ascertain if {open_quotes}green{close_quotes} building options reflect similar positive cyclical patterns found in nature (i.e. recyclability, recycled content, renewable resources, etc.). We additionally consider economic, human health and synergistic ecological impacts associated with our building choices and characterize the best choices as {open_quotes}green.{close_quotes} Our ultimate goal is to identify and use those {open_quotes}green{close_quotes} materials and processes that provide well for us now and do not compromise similar benefits for future generations. The original partnership developed for this project shifted during the year from a project stressing advanced (many prototypical) {open_quotes}green{close_quotes} building materials and techniques in a research and demonstration context, to off-the-shelf but underutilized {open_quotes}green{close_quotes} materials in the practical social context of using {open_quotes}green{close_quotes} technologies for low income housing. That project, discussed in this report, is called the Green Habitat Learning Project.

  17. Personal, Social, and Environmental Correlates of Walking to School Behaviors: Case Study in Austin, Texas

    Directory of Open Access Journals (Sweden)

    Xuemei Zhu

    2008-01-01

    Full Text Available Walking is an affordable and environmentally clean mode of transportation that can bring additional benefits as healthy physical activity. This cross-sectional study examines the prevalence and correlates of walking to or from school in eight elementary schools in Austin, Texas, which have high percentages of low-income, Hispanic students. A survey of 1,281 parents was conducted, including questions about personal, social, and environmental factors that may influence their decisions on the children's school transportation. Binary logistic regressions were used to estimate the odds of choosing walking as the children's typical school travel mode. The results showed that walking was a typical mode for 28 and 34% of trips to and from school, respectively, and mostly accompanied by an adult. Parents' education level, family's car ownership, children's and parents' personal barriers, and having the school bus service reduced the likelihood of walking, while positive peer influences encouraged walking. Among the physical environmental factors, living close to school was the strongest positive predictor; safety concerns and the presence of highway or freeway en route were negative correlates. We concluded that the location of school is a key, as it determines the travel distance and the presence of highway or freeway en route. In addition to environmental improvements, educational and other assistance programs are needed for both parents and children to overcome their personal barriers and safety concerns. Health and disparity issues require further attention, as many underprivileged children have no other means of school transportation but walking in unsafe and poor environments.

  18. Nutritional sustainability of pet foods.

    Science.gov (United States)

    Swanson, Kelly S; Carter, Rebecca A; Yount, Tracy P; Aretz, Jan; Buff, Preston R

    2013-03-01

    Sustainable practices meet the needs of the present without compromising the ability of future generations to meet their needs. Applying these concepts to food and feed production, nutritional sustainability is the ability of a food system to provide sufficient energy and essential nutrients required to maintain good health in a population without compromising the ability of future generations to meet their nutritional needs. Ecological, social, and economic aspects must be balanced to support the sustainability of the overall food system. The nutritional sustainability of a food system can be influenced by several factors, including the ingredient selection, nutrient composition, digestibility, and consumption rates of a diet. Carbon and water footprints vary greatly among plant- and animal-based ingredients, production strategy, and geographical location. Because the pet food industry is based largely on by-products and is tightly interlinked with livestock production and the human food system, however, it is quite unique with regard to sustainability. Often based on consumer demand rather than nutritional requirements, many commercial pet foods are formulated to provide nutrients in excess of current minimum recommendations, use ingredients that compete directly with the human food system, or are overconsumed by pets, resulting in food wastage and obesity. Pet food professionals have the opportunity to address these challenges and influence the sustainability of pet ownership through product design, manufacturing processes, public education, and policy change. A coordinated effort across the industry that includes ingredient buyers, formulators, and nutritionists may result in a more sustainable pet food system. PMID:23493530

  19. PET AND PET-CT: PHYSICAL PRINCIPLE AND MEDICAL APLICATIONS

    Directory of Open Access Journals (Sweden)

    V.Rusu

    2007-04-01

    Full Text Available Positron emission tomography (PET is a noninvasive imaging method that can “see” the metabolisms inside the living cells. It involves the acquisition of functional images based on the detection of radiation coming from the positron emission of a radiotracer administered to the patient. This radiotracer can be a metabolic analog, like is the case of glucose analog 2-[fluorine-18]-fluoro-2-deoxy-D-glucose (18FDG, the most commonly used PET radiotracer. PET images of the human body are used to evaluate a variety of diseases, most often to detect cancer and to examine the effects of cancer therapy by characterizing cell viability and biochemical changes in the cell. It is potentially useful in cancer imaging because the increased metabolism of tumor cells leads to increased uptake of glucose, and, therefore, uptake of 18FDG, also. PET-CT is the fusion of functional and anatomic information acquired almost simultaneously, that lets us see both the structural anatomy and the functional data on the same image. They complete each other: if PET scan is powerful in evaluating the functional characteristics of the tissues, CT is a powerful structural resolution imaging method. The highly sensitive PET scan detects the metabolic signal of actively growing cancer cells in the body and the CT scan provides a detailed picture of the internal anatomy that reveals sites, size and shape of cancer tissue. Alone, each imaging test has particular benefits and limitations but when the results of PET and CT scans are "fused" together, the combined image provides complete information on cancer location and metabolism.

  20. A Preliminary internet survey of pet rabbit owners’ characteristics

    Directory of Open Access Journals (Sweden)

    J.A. Oxley

    2015-12-01

    Full Text Available This study aimed to conduct a preliminary survey to investigate basic ownership factors, frequency of microchipping and insurance and views of pet rabbit owners  n these areas and general rabbit management. More specifically, we aimed to investigate whether owners possess insurance, whether their rabbits are microchipped, and owners’ views on the recommendations relating to rabbits (e.g. recommended enclosure sizes and the law. A questionnaire was designed and promulgated through social media sites and rabbit forums. A total of 1183 responses were received. Just over 29% of respondents sourced their rabbits through rescue centres. 73.9% (867/1174 of owners stated that they had no pet insurance for their rabbits. Concerning microchips, 78.3% (919/1173 of rabbits were not microchipped, while 21.7% (254/1173 were. This preliminary study found that the majority of individuals are of the opinion that the relevant law is insufficiently publicised. A more detailed study would be beneficial to investigate and provide further insight into rabbit owners and their views and concerns for rabbits. The results of such a study could help formulate rabbit-related information and guidelines which in turn could have a direct impact on pet rabbit welfare.

  1. The ideal Atomic Centre; Le Centre Atomique ideal

    Energy Technology Data Exchange (ETDEWEB)

    Mas, R. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1965-07-01

    The author presents considerations which should prove to be of interest to all those who have to design, to construct and to operate a nuclear research centre. A large number of the ideas presented can also be applied to non-nuclear scientific research centres. In his report the author reviews: various problems with which the constructor is faced: ground-plan, infrastructure, buildings and the large units of scientific equipment in the centre, and those problems facing the director: maintenance, production, supplies, security. The author stresses the relationship which ought to exist between the research workers and the management. With this aim in view he proposes the creation of National School for Administration in Research which would train administrative executives for public or private organisations; they would be specialised in the fields of fundamental or applied research. (author) [French] L'auteur propose une base de reflexions a tous ceux qui doivent concevoir, realiser et faire vivre un Centre d'Etudes Nucleaires. Un grand nombre des idees exprimees peut d'ailleurs s'appliquer a un Centre d'Etudes Scientifiques non nucleaires. Dans son ouvrage, l'auteur passe en revue les differents problemes qui se posent au constructeur: plan, masse, infrastructure, batiments et grands appareils du Centre, et ceux qu'a a resoudre le directeur: entretien, fabrication, approvisionnements, securite. L'auteur insiste sur l'aspect des rapports qui doivent exister entre les chercheurs et ceux qui les administrent. Il propose a cette fin la creation d'une Ecole Nationale d'Administration de la Recherche qui formerait des cadres administratifs pour les organismes publics ou prives, specialises dans la Recherche fondamentale ou appliquee. (auteur)

  2. Focal thyroid incidentalomas identified with whole-body FDG-PET warrant further investigation.

    LENUS (Irish Health Repository)

    Prichard, R S

    2012-02-01

    Fluorodeoxyglucose (FDG) whole body positron emission computed tomography (PET-CT) detects clinically occult malignancy. The aim of this study was to assess the prevalence and significance of focal thyroid 18F - fluorodeoxyglucose uptake. A retrospective review of all patients who had FDG PET-CT examinations, in a single tertiary referral centre was performed. PET scan findings and the final pathological diagnosis were collated. 2105 scans were reviewed. Focal uptake was identified in 35 (1.66%) patients. Final surgical histology was available on eight patients, which confirmed papillary carcinoma in four (20%) patients and lymphoma and metastatic disease in two patients respectively. This gave an overall malignancy rate in focal thyroid uptake of at least 33%. Thyroid incidentalomas occurred with a frequency of 2.13%, with an associated malignancy rate of at least 33% in focal thyroid uptake. The high malignancy rate associated with focal thyroid uptake mandates further investigation in medically fit patients.

  3. Gamma camera based FDG PET in oncology

    International Nuclear Information System (INIS)

    Positron Emission Tomography(PET) was introduced as a research tool in the 1970s and it took about 20 years before PET became an useful clinical imaging modality. In the USA, insurance coverage for PET procedures in the 1990s was the turning point, I believe, for this progress. Initially PET was used in neurology but recently more than 80% of PET procedures are in oncological applications. I firmly believe, in the 21st century, one can not manage cancer patients properly without PET and PET is very important medical imaging modality in basic and clinical sciences. PET is grouped into 2 categories; conventional (c) and gamma camera based (CB) PET. CBPET is more readily available utilizing dual-head gamma cameras and commercially available FDG to many medical centers at low cost to patients. In fact there are more CBPET in operation than cPET in the USA. CBPET is inferior to cPET in its performance but clinical studies in oncology is feasible without expensive infrastructures such as staffing, rooms and equipments. At Ajou university Hospital, CBPET was installed in late 1997 for the first time in Korea as well as in Asia and the system has been used successfully and effectively in oncological applications. Our was the fourth PET operation in Korea and I believe this may have been instrumental for other institutions got interested in clinical PET. The following is a brief description of our clinical experience of FDG CBPET in oncology

  4. The Galactic centre pulsar population

    CERN Document Server

    Chennamangalam, Jayanth

    2013-01-01

    The recent discovery of a magnetar in the Galactic centre region has allowed Spitler et al. to characterize the interstellar scattering in that direction. They find that the temporal broadening of the pulse profile of the magnetar is substantially less than that predicted by models of the electron density of that region. This raises the question of what the plausible limits for the number of potentially observable pulsars - i.e., the number of pulsars beaming towards the Earth - in the Galactic centre region are. In this paper, using realistic assumptions, we show that the potentially observable population of pulsars in the inner parsec has a conservative upper limit of $\\sim$950, and that it is premature to conclude that the number of pulsars in this region is small. We also show that the observational results so far are consistent with this number and make predictions for future radio pulsar surveys of the Galactic centre.

  5. Construction of the Wigner Data Centre

    CERN Multimedia

    2013-01-01

    A remote extension of the CERN data centre has recently been inaugurated. Hosted at the Wigner Research Centre for Physics in Hungary, it provides extra computing power required to cover CERN’s needs. This video presents the construction of the Wigner Data Centre from initial demolishing work through to its completion and details the major technical characteristics of the Data Centre.

  6. Evaluation of water-quality data and monitoring program for Lake Travis, near Austin, Texas

    Science.gov (United States)

    Rast, Walter; Slade, Raymond M., Jr.

    1998-01-01

    Statistical analyses were made of selected water-quality properties and constituents for Lake Travis, northwest of Austin in central Texas. Objectives for the evaluation were: (1) to provide information on levels of selected water-quality properties or constituents to use as reference values for assessing the future effectiveness of the Lake Travis Nonpoint-Source Control ordinance of the Lower Colorado River Authority; and (2) to determine whether water-quality constituents at any of the sampling sites are statistically redundant with other sites and, thus, can be discontinued without loss of information. The data were grouped into two periods?the thermally stratified period (May through November) and the mixed period (December through April). Lake Travis is a biologically unproductive reservoir with acceptable water quality for virtually all current water uses. Nutrient (nitrogen, phosphorus) concentrations tend to be small in the reservoir throughout the year, indicating nutrient limitation of maximum phytoplankton biomass. On the basis of traditional limnological properties, Lake Travis exhibits small biological productivity and exceptional water transparency. However, dissolved oxygen concentrations for bottom samples often decrease to less than 5 milligrams per liter throughout the reservoir, especially during the thermally stratified period. Statistical comparisons were made between data collected at the surface and at the bottom at each sampling site to determine statistical similarities. The available data were insufficient to perform the comparisons for nitrite nitrogen and dissolved orthophosphate phosphorus. In addition, no bottom data were available at the most upstream site because the shallow bottom was commonly above the thermocline. The multiple-comparison tests indicate that, for some constituents, a single sampling site for a constituent or property might adequately characterize the water quality of Lake Travis for that constituent or property

  7. PET and PET/CT in oncology: the key of diagnostic challenge

    International Nuclear Information System (INIS)

    In this presentation authors present use of positron emission tomography (PET) in oncology. This lecture is divided to the following parts: (1) Assessment of treatment response; (2) Treatment monitoring by PET: clinical examples; (3) PET for early response assessment; (4) Use of PET in Radiotherapy planning

  8. Exercises in PET Image Reconstruction

    Science.gov (United States)

    Nix, Oliver

    These exercises are complementary to the theoretical lectures about positron emission tomography (PET) image reconstruction. They aim at providing some hands on experience in PET image reconstruction and focus on demonstrating the different data preprocessing steps and reconstruction algorithms needed to obtain high quality PET images. Normalisation, geometric-, attenuation- and scatter correction are introduced. To explain the necessity of those some basics about PET scanner hardware, data acquisition and organisation are reviewed. During the course the students use a software application based on the STIR (software for tomographic image reconstruction) library 1,2 which allows them to dynamically select or deselect corrections and reconstruction methods as well as to modify their most important parameters. Following the guided tutorial, the students get an impression on the effect the individual data precorrections have on image quality and what happens if they are forgotten. Several data sets in sinogram format are provided, such as line source data, Jaszczak phantom data sets with high and low statistics and NEMA whole body phantom data. The two most frequently used reconstruction algorithms in PET image reconstruction, filtered back projection (FBP) and the iterative OSEM (ordered subset expectation maximation) approach are used to reconstruct images. The exercise should help the students gaining an understanding what the reasons for inferior image quality and artefacts are and how to improve quality by a clever choice of reconstruction parameters.

  9. PET for Staging of Esophageal Cancer

    Institute of Scientific and Technical Information of China (English)

    A.H.Hoelscher

    2004-01-01

    FDG-PET is of clinical value especially for detection of distant metastases or recurrent esophageal cancer. For the staging of primary tumor or locoregional lymph node metastasis PET is currently not suitable.

  10. PET/MRI in cancer patients

    DEFF Research Database (Denmark)

    Kjær, Andreas; Loft, Annika; Law, Ian;

    2013-01-01

    described include brain tumors, pediatric oncology as well as lung, abdominal and pelvic cancer. In general the cases show that PET/MRI performs well in all these types of cancer when compared to PET/CT. However, future large-scale clinical studies are needed to establish when to use PET/MRI. We envision......Combined PET/MRI systems are now commercially available and are expected to change the medical imaging field by providing combined anato-metabolic image information. We believe this will be of particular relevance in imaging of cancer patients. At the Department of Clinical Physiology, Nuclear...... Medicine & PET at Rigshospitalet in Copenhagen we installed an integrated PET/MRI in December 2011. Here, we describe our first clinical PET/MR cases and discuss some of the areas within oncology where we envision promising future application of integrated PET/MR imaging in clinical routine. Cases...

  11. 7 CFR 500.10 - Pets.

    Science.gov (United States)

    2010-01-01

    ... NATIONAL ARBORETUM Conduct on U.S. National Arboreturm Property § 500.10 Pets. Pets brought upon USNA property must have proper vaccinations and, except assistance trained animals, must be kept on leash at...

  12. Children's drawings and attachment to pets.

    Science.gov (United States)

    Kidd, A H; Kidd, R M

    1995-08-01

    To help confirm the concept that distances placed between the self and other figures in children's drawings represent emotional distances, 242 pet-owning and 35 nonpet-owning kindergartners through eighth graders drew pictures of themselves, a pet, and/or a family member. Owners drew pets significantly closer than family-figures although the younger the child, the greater the distance between self and pet. Older children drew themselves holding pets significantly more often, but younger children placed the family-figure between the self and the pet significantly more often. There were no significant gender differences in self-figure/pet-figure distances, but cats, dogs, caged animals, and farm animals were placed significantly closer to self-figures than were fish. Over-all, owners were clearly emotionally closer to pets than to family members, but nonowners were as close emotionally to family members as were owners. PMID:7501763

  13. {sup 18}F-FDOPA PET/CT imaging of insulinoma revisited

    Energy Technology Data Exchange (ETDEWEB)

    Imperiale, Alessio; Namer, Izzie-Jacques [University Hospitals of Strasbourg, Department of Biophysics and Nuclear Medicine, Strasbourg (France); University of Strasbourg/CNRS and FMTS, Faculty of Medicine, ICube - UMR 7357, Strasbourg (France); Sebag, Frederic [Aix-Marseille University, Department of Endocrine Surgery, La Timone University Hospital, Marseille (France); Vix, Michel [University of Strasbourg, Department of General, Digestive, and Endocrine Surgery, IRCAD-IHU, Strasbourg (France); Castinetti, Frederic [Aix-Marseille University, Department of Endocrinology, Diabetes and Metabolic Disorders, La Timone University Hospital, Marseille (France); Kessler, Laurence; Moreau, Francois [University of Strasbourg, Department of Diabetology, University Hospital of Strasbourg, Strasbourg (France); Bachellier, Philippe [University Hospitals of Strasbourg, Department of Visceral Surgery and Transplantation, Strasbourg (France); Guillet, Benjamin; Mundler, Olivier [Aix-Marseille University, Department of Nuclear Medicine, La Timone University Hospital, CERIMED, Marseille (France); Taieb, David [Aix-Marseille University, Department of Nuclear Medicine, La Timone University Hospital, CERIMED, Marseille (France); Aix-Marseille University, Biophysics and Nuclear Medecine, La Timone University Hospital, European Center for Research in Medical Imaging, Marseille (France)

    2014-11-01

    {sup 18}F-FDOPA PET imaging is increasingly used in the work-up of patients with neuroendocrine tumours. It has been shown to be of limited value in localizing pancreatic insulin-secreting tumours in adults with hyperinsulinaemic hypoglycaemia (HH) mainly due to {sup 18}F-FDOPA uptake by the whole pancreatic gland. The objective of this study was to review our experience with {sup 18}F-FDOPA PET/CT imaging with carbidopa (CD) premedication in patients with HH in comparison with PET/CT studies performed without CD premedication in an independent population. A retrospective study including 16 HH patients who were investigated between January 2011 and December 2013 using {sup 18}F-FDOPA PET/CT (17 examinations) in two academic endocrine tumour centres was conducted. All PET/CT examinations were performed under CD premedication (200 mg orally, 1 - 2 h prior to tracer injection). The PET/CT acquisition protocol included an early acquisition (5 min after {sup 18}F-FDOPA injection) centred over the upper abdomen and a delayed whole-body acquisition starting 20 - 30 min later. An independent series of eight consecutive patients with HH and investigated before 2011 were considered for comparison. All patients had a reference whole-body PET/CT scan performed about 1 h after {sup 18}F-FDOPA injection. In all cases, PET/CT was performed without CD premedication. In the study group, {sup 18}F-FDOPA PET/CT with CD premedication was positive in 8 out of 11 patients with histologically proven insulinoma (73 %). All {sup 18}F-FDOPA PET/CT-avid insulinomas were detected on early images and 5 of 11 (45 %) on delayed ones. The tumour/normal pancreas uptake ratio was not significantly different between early and delayed acquisitions. Considering all patients with HH, including those without imaging evidence of disease, the detection rate of the primary lesions using CD-assisted {sup 18}F-FDOPA PET/CT was 53 %, showing 9 insulinomas in 17 studies performed. In the control group (without

  14. 18F-FDOPA PET/CT imaging of insulinoma revisited

    International Nuclear Information System (INIS)

    18F-FDOPA PET imaging is increasingly used in the work-up of patients with neuroendocrine tumours. It has been shown to be of limited value in localizing pancreatic insulin-secreting tumours in adults with hyperinsulinaemic hypoglycaemia (HH) mainly due to 18F-FDOPA uptake by the whole pancreatic gland. The objective of this study was to review our experience with 18F-FDOPA PET/CT imaging with carbidopa (CD) premedication in patients with HH in comparison with PET/CT studies performed without CD premedication in an independent population. A retrospective study including 16 HH patients who were investigated between January 2011 and December 2013 using 18F-FDOPA PET/CT (17 examinations) in two academic endocrine tumour centres was conducted. All PET/CT examinations were performed under CD premedication (200 mg orally, 1 - 2 h prior to tracer injection). The PET/CT acquisition protocol included an early acquisition (5 min after 18F-FDOPA injection) centred over the upper abdomen and a delayed whole-body acquisition starting 20 - 30 min later. An independent series of eight consecutive patients with HH and investigated before 2011 were considered for comparison. All patients had a reference whole-body PET/CT scan performed about 1 h after 18F-FDOPA injection. In all cases, PET/CT was performed without CD premedication. In the study group, 18F-FDOPA PET/CT with CD premedication was positive in 8 out of 11 patients with histologically proven insulinoma (73 %). All 18F-FDOPA PET/CT-avid insulinomas were detected on early images and 5 of 11 (45 %) on delayed ones. The tumour/normal pancreas uptake ratio was not significantly different between early and delayed acquisitions. Considering all patients with HH, including those without imaging evidence of disease, the detection rate of the primary lesions using CD-assisted 18F-FDOPA PET/CT was 53 %, showing 9 insulinomas in 17 studies performed. In the control group (without CD premedication, eight patients), the final

  15. Global trade in exotic pets 2006-2012.

    Science.gov (United States)

    Bush, Emma R; Baker, Sandra E; Macdonald, David W

    2014-06-01

    International trade in exotic pets is an important and increasing driver of biodiversity loss and often compromises the standards required for good animal welfare. We systematically reviewed the scientific and gray literature and used the United Nations Environment Programme - World Conservation Monitoring Centre (UNEP-WCMC) Convention on International Trade in Endangered Species of Wild Fauna and Flora (CITES) trade database to establish temporal and geographical trade patterns of live exotic birds, mammals, and reptiles and to describe trends in research, taxonomic representation, and level of threat and legal protection of species traded. Birds were the most species-rich and abundant class reported in trade; reptiles were second most abundant but unusually the most studied in this context; and mammals were least abundant in trade. Mammalian and reptilian species traded as pets were more likely to be threatened than expected by random. There have been a substantial number of Appendix I listed captive-bred mammals and birds and wild-caught birds and reptiles reported in trade to CITES. We identified the Middle East's emerging role as a driver of demand for exotic pets of all taxa alongside the well-established and increasing role of South America and Southeast Asia in the market. Europe, North America, and the Middle East featured most heavily in trade reports to CITES, whereas trade involving South America and Southeast Asia were given most emphasis in the literature. For effective monitoring of and appropriate response to the international exotic pet trade, it is imperative that the reliability and detail of CITES trade reports improve and that scientific research be directed toward those taxa and locations that are most vulnerable. PMID:24661260

  16. Proton Therapy Verification with PET Imaging

    OpenAIRE

    Zhu, Xuping; Fakhri, Georges El

    2013-01-01

    Proton therapy is very sensitive to uncertainties introduced during treatment planning and dose delivery. PET imaging of proton induced positron emitter distributions is the only practical approach for in vivo, in situ verification of proton therapy. This article reviews the current status of proton therapy verification with PET imaging. The different data detecting systems (in-beam, in-room and off-line PET), calculation methods for the prediction of proton induced PET activity distributions...

  17. Establishing the first PET and cyclotron facility in Pakistan - Experiences of a third world country

    International Nuclear Information System (INIS)

    Full text: Aim/Background: The presentation is about the efforts and difficulties faced in introducing the idea of Pakistan's first ever medical PET Centre in a hospital environment. The idea of PET and Cyclotron facility in the country was launched in 2001 as soon as the technology got clinical acceptance at international level. Approval of FDA and insurance cover for the imaging procedures helped in this regard. The novel idea of having new and expensive PET technology in the country intrigued the technical personnel but was prohibitive for the financial managers. The initial budgetary estimate of establishing a PET-Cyclotron centre was nearly US$ 5.0 Million, enough to have a new Nuclear Medicine/Oncology Institute or ample for refurbishing the 2-3 existing facilities. In year 2003-04 the idea was broached to the higher ups when presentations were held with the PET companies and their experts. Soon after this, an international Nuclear Medicine Conference held in Lahore provided an excellent chance to introduce the technology to a wider national audience. Participation and lectures by the ARCCNM experts was extremely helpful in this regard. A feasibility study was performed locally in order to locate the best suitable place for the PET facility in the country. Institute of Nuclear Medicine and Oncology (INMOL), Lahore was chosen to have the Pakistan's first ever PET and Cyclotron facility. Financial and logistical support was gathered from Federal and Provincial governments. Help of IAEA was sought in order to formulate the tender documents. It took almost a year to evaluate the technical and financial bids from various companies. The contract was finalized after 18 months of floating the tenders. The project is in execution phase now. A TC project from IAEA has enabled us to scramble technical assistance in various fields. Conclusion: IAEA help is much required in performing a feasibility study and having technical support for Human Resource Development

  18. PET Metabolic Biomarkers for Cancer

    Science.gov (United States)

    Croteau, Etienne; Renaud, Jennifer M.; Richard, Marie Anne; Ruddy, Terrence D.; Bénard, François; deKemp, Robert A.

    2016-01-01

    The body’s main fuel sources are fats, carbohydrates (glucose), proteins, and ketone bodies. It is well known that an important hallmark of cancer cells is the overconsumption of glucose. Positron emission tomography (PET) imaging using the glucose analog 18F-fluorodeoxyglucose (18F-FDG) has been a powerful cancer diagnostic tool for many decades. Apart from surgery, chemotherapy and radiotherapy represent the two main domains for cancer therapy, targeting tumor proliferation, cell division, and DNA replication—all processes that require a large amount of energy. Currently, in vivo clinical imaging of metabolism is performed almost exclusively using PET radiotracers that assess oxygen consumption and mechanisms of energy substrate consumption. This paper reviews the utility of PET imaging biomarkers for the detection of cancer proliferation, vascularization, metabolism, treatment response, and follow-up after radiation therapy, chemotherapy, and chemotherapy-related side effects.

  19. PET and SPECT in neurology

    Energy Technology Data Exchange (ETDEWEB)

    Dierckx, Rudi A.J.O. [Groningen University Medical Center (Netherlands). Dept. of Nuclear Medicine and Molecular Imaging; Ghent Univ. (Belgium). Dept. of Radiology and Nuclear Medicine; Vries, Erik F.J. de; Waarde, Aren van [Groningen University Medical Center (Netherlands). Dept. of Nuclear Medicine and Molecular Imaging; Otte, Andreas (ed.) [Univ. of Applied Sciences Offenburg (Germany). Faculty of Electrical Engineering and Information Technology

    2014-07-01

    PET and SPECT in Neurology highlights the combined expertise of renowned authors whose dedication to the investigation of neurological disorders through nuclear medicine technology has achieved international recognition. Classical neurodegenerative disorders are discussed as well as cerebrovascular disorders, brain tumors, epilepsy, head trauma, coma, sleeping disorders, and inflammatory and infectious diseases of the CNS. The latest results in nuclear brain imaging are detailed. Most chapters are written jointly by a clinical neurologist and a nuclear medicine specialist to ensure a multidisciplinary approach. This state-of-the-art compendium will be valuable to anybody in the field of neuroscience, from the neurologist and the radiologist/nuclear medicine specialist to the interested general practitioner and geriatrician. It is the second volume of a trilogy on PET and SPECT imaging in the neurosciences, the other volumes covering PET and SPECT in psychiatry and in neurobiological systems.

  20. PET and SPECT in neurology

    International Nuclear Information System (INIS)

    PET and SPECT in Neurology highlights the combined expertise of renowned authors whose dedication to the investigation of neurological disorders through nuclear medicine technology has achieved international recognition. Classical neurodegenerative disorders are discussed as well as cerebrovascular disorders, brain tumors, epilepsy, head trauma, coma, sleeping disorders, and inflammatory and infectious diseases of the CNS. The latest results in nuclear brain imaging are detailed. Most chapters are written jointly by a clinical neurologist and a nuclear medicine specialist to ensure a multidisciplinary approach. This state-of-the-art compendium will be valuable to anybody in the field of neuroscience, from the neurologist and the radiologist/nuclear medicine specialist to the interested general practitioner and geriatrician. It is the second volume of a trilogy on PET and SPECT imaging in the neurosciences, the other volumes covering PET and SPECT in psychiatry and in neurobiological systems.

  1. The rise and fall of PET and PET/CT. A German perspective

    International Nuclear Information System (INIS)

    PET is being considered a diagnostic commodity in clinical practice worldwide and thus receives increasing attention by health insurances and governmental organizations. In Germany, however, neither PET nor PET/CT are subject to reimbursement. This renders clinical PET and PET/CT imaging a challenge both in general hospital environment and in private practice. This article describes briefly these challenges, which are not solely related to turf battles and associated costs. (orig.)

  2. THE CHARACTERISTICS OF EEC PET INSTRUMENTATION

    NARCIS (Netherlands)

    PAANS, AMJ

    1991-01-01

    As a result of a Guide-Questionnaire distributed among all European PET centers an inventory of the European PET instrumentation has become available in a data base. An overview and analysis of the European PET equipment, cyclotrons, scanners and software, together with some global information on th

  3. 36 CFR 13.1234 - Pets.

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Pets. 13.1234 Section 13.1234 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR NATIONAL PARK... § 13.1234 Pets. Possessing a pet in the BCDA is prohibited....

  4. Kinetic modeling in PET imaging of hypoxia

    DEFF Research Database (Denmark)

    Li, Fan; Jørgensen, Jesper Tranekjær; Hansen, Anders E;

    2014-01-01

    be used for non-invasive mapping of tissue oxygenation in vivo and several hypoxia specific PET tracers have been developed. Evaluation of PET data in the clinic is commonly based on visual assessment together with semiquantitative measurements e.g. standard uptake value (SUV). However, dynamic PET...

  5. Saying Goodbye: Pet Loss and Its Implications

    Science.gov (United States)

    Duffey, Thelma

    2005-01-01

    Pets can be loyal, loving, and entertaining members of a family. Their deaths are generally experienced as painful losses by the people who love them, even though the grief experience is often culturally disenfranchised. In this manuscript, we discuss the role that pets can play in a person's life; the effects that pet loss can have on the people…

  6. LDE centres: sprint or marathon?

    NARCIS (Netherlands)

    Bonger, S.; Van Rein, E.

    2015-01-01

    The aim of the Strategic Leiden-Delft-Erasmus Alliance, established by the three universities in 2012, was to improve research and education and competitiveness. Projects are intended to develop from the ground up, which led to the establishment of eight joint centres in 2013. A quick look around re

  7. Understanding advertising in pet nutrition.

    OpenAIRE

    Brown, R G

    1994-01-01

    Advertising is part of the effort to attract attention of consumers to products, in this case, pet foods. It is generally benign in its effect, but it can be misleading, although rarely deliberately so. It uses a specialized vocabulary, which must be mastered if one is to understand what is intended. For all of the expense and effort, advertising figures directly in relatively few decisions to purchase. Its main intention is to call our attention to a particular pet food and to give that prod...

  8. PET and PET/CT in malignant melanoma

    International Nuclear Information System (INIS)

    The advantages that it has the PET/CT are: 1. It diminishes mainly positive false lesions. It identifies physiologic accumulate places. 2. It diminishes in smaller grade false negative. Small injuries. Injuries with low grade concentration. Injure on intense activity areas. 3. Precise anatomical localization of accumulate places. 4. Reduction of the acquisition time. (Author)

  9. Competitive advantage of PET/MRI.

    Science.gov (United States)

    Jadvar, Hossein; Colletti, Patrick M

    2014-01-01

    Multimodality imaging has made great strides in the imaging evaluation of patients with a variety of diseases. Positron emission tomography/computed tomography (PET/CT) is now established as the imaging modality of choice in many clinical conditions, particularly in oncology. While the initial development of combined PET/magnetic resonance imaging (PET/MRI) was in the preclinical arena, hybrid PET/MR scanners are now available for clinical use. PET/MRI combines the unique features of MRI including excellent soft tissue contrast, diffusion-weighted imaging, dynamic contrast-enhanced imaging, fMRI and other specialized sequences as well as MR spectroscopy with the quantitative physiologic information that is provided by PET. Most evidence for the potential clinical utility of PET/MRI is based on studies performed with side-by-side comparison or software-fused MRI and PET images. Data on distinctive utility of hybrid PET/MRI are rapidly emerging. There are potential competitive advantages of PET/MRI over PET/CT. In general, PET/MRI may be preferred over PET/CT where the unique features of MRI provide more robust imaging evaluation in certain clinical settings. The exact role and potential utility of simultaneous data acquisition in specific research and clinical settings will need to be defined. It may be that simultaneous PET/MRI will be best suited for clinical situations that are disease-specific, organ-specific, related to diseases of the children or in those patients undergoing repeated imaging for whom cumulative radiation dose must be kept as low as reasonably achievable. PET/MRI also offers interesting opportunities for use of dual modality probes. Upon clear definition of clinical utility, other important and practical issues related to business operational model, clinical workflow and reimbursement will also be resolved.

  10. The MiniPET: a didactic PET system

    Science.gov (United States)

    Pedro, R.; Silva, J.; Gurriana, L.; Silva, J. M.; Maio, A.; Soares Augusto, J.

    2013-03-01

    The MiniPET project aims to design and build a small PET system. It consists of two 4 × 4 matrices of 16 LYSO scintillator crystals and two PMTs with 16 channels resulting in a low cost system with the essential functionality of a clinical PET instrument. It is designed to illustrate the physics of the PET technique and to provide a didactic platform for the training of students and nuclear imaging professionals as well as for scientific outreach. The PET modules can be configured to test for the coincidence of 511 keV gamma rays. The model has a flexible mechanical setup [1] and can simulate 14 diferent ring geometries, from a configuration with as few as 18 detectors per ring (ring radius phi=51 mm), up to a geometry with 70 detectors per ring (phi=200 mm). A second version of the electronic system [2] allowed measurement and recording of the energy deposited in 4 detector channels by photons from a 137Cs radioactive source and by photons resulting of the annihilation of positrons from a 22Na radioactive source. These energy spectra are used for detector performance studies, as well as angular dependency studies. In this paper, the mechanical setup, the front-end high-speed analog electronics, the digital acquisition and control electronics implemented in a FPGA, as well as the data-transfer interface between the FPGA board and a host PC are described. Recent preliminary results obtained with the 4 active channels in the prototype are also presented.

  11. Development of PET/MRI with insertable PET for simultaneous PET and MR imaging of human brain

    Energy Technology Data Exchange (ETDEWEB)

    Jung, Jin Ho; Choi, Yong, E-mail: ychoi.image@gmail.com; Jung, Jiwoong; Kim, Sangsu; Lim, Hyun Keong; Im, Ki Chun [Department of Electronic Engineering, Sogang University, 35 Baekbeom-ro, Mapo-gu, Seoul 121-742 (Korea, Republic of); Oh, Chang Hyun; Park, Hyun-wook [Department of Electrical Engineering, Korea Advanced Institute of Science and Technology, 291 Daehak-ro, Yuseong-gu, Daejeon 305-701 (Korea, Republic of); Kim, Kyung Min; Kim, Jong Guk [Korea Institute of Radiological and Medical Science, 75 Nowon-ro, Nowon-gu, Seoul 139-709 (Korea, Republic of)

    2015-05-15

    Purpose: The purpose of this study was to develop a dual-modality positron emission tomography (PET)/magnetic resonance imaging (MRI) with insertable PET for simultaneous PET and MR imaging of the human brain. Methods: The PET detector block was composed of a 4 × 4 matrix of detector modules, each consisting of a 4 × 4 array LYSO coupled to a 4 × 4 Geiger-mode avalanche photodiode (GAPD) array. The PET insert consisted of 18 detector blocks, circularly mounted on a custom-made plastic base to form a ring with an inner diameter of 390 mm and axial length of 60 mm. The PET gantry was shielded with gold-plated conductive fabric tapes with a thickness of 0.1 mm. The charge signals of PET detector transferred via 4 m long flat cables were fed into the position decoder circuit. The flat cables were shielded with a mesh-type aluminum sheet with a thickness of 0.24 mm. The position decoder circuit and field programmable gate array-embedded DAQ modules were enclosed in an aluminum box with a thickness of 10 mm and located at the rear of the MR bore inside the MRI room. A 3-T human MRI system with a Larmor frequency of 123.7 MHz and inner bore diameter of 60 cm was used as the PET/MRI hybrid system. A custom-made radio frequency (RF) coil with an inner diameter of 25 cm was fabricated. The PET was positioned between gradient and the RF coils. PET performance was measured outside and inside the MRI scanner using echo planar imaging, spin echo, turbo spin echo, and gradient echo sequences. MRI performance was also evaluated with and without the PET insert. The stability of the newly developed PET insert was evaluated and simultaneous PET and MR images of a brain phantom were acquired. Results: No significant degradation of the PET performance caused by MR was observed when the PET was operated using various MR imaging sequences. The signal-to-noise ratio of MR images was slightly degraded due to the PET insert installed inside the MR bore while the homogeneity was

  12. Development of PET/MRI with insertable PET for simultaneous PET and MR imaging of human brain

    International Nuclear Information System (INIS)

    Purpose: The purpose of this study was to develop a dual-modality positron emission tomography (PET)/magnetic resonance imaging (MRI) with insertable PET for simultaneous PET and MR imaging of the human brain. Methods: The PET detector block was composed of a 4 × 4 matrix of detector modules, each consisting of a 4 × 4 array LYSO coupled to a 4 × 4 Geiger-mode avalanche photodiode (GAPD) array. The PET insert consisted of 18 detector blocks, circularly mounted on a custom-made plastic base to form a ring with an inner diameter of 390 mm and axial length of 60 mm. The PET gantry was shielded with gold-plated conductive fabric tapes with a thickness of 0.1 mm. The charge signals of PET detector transferred via 4 m long flat cables were fed into the position decoder circuit. The flat cables were shielded with a mesh-type aluminum sheet with a thickness of 0.24 mm. The position decoder circuit and field programmable gate array-embedded DAQ modules were enclosed in an aluminum box with a thickness of 10 mm and located at the rear of the MR bore inside the MRI room. A 3-T human MRI system with a Larmor frequency of 123.7 MHz and inner bore diameter of 60 cm was used as the PET/MRI hybrid system. A custom-made radio frequency (RF) coil with an inner diameter of 25 cm was fabricated. The PET was positioned between gradient and the RF coils. PET performance was measured outside and inside the MRI scanner using echo planar imaging, spin echo, turbo spin echo, and gradient echo sequences. MRI performance was also evaluated with and without the PET insert. The stability of the newly developed PET insert was evaluated and simultaneous PET and MR images of a brain phantom were acquired. Results: No significant degradation of the PET performance caused by MR was observed when the PET was operated using various MR imaging sequences. The signal-to-noise ratio of MR images was slightly degraded due to the PET insert installed inside the MR bore while the homogeneity was

  13. Radiation dose to radiosensitive organs in PET/CT myocardial perfusion examination using versatile optical fibre

    Science.gov (United States)

    Salasiah, M.; Nordin, A. J.; Fathinul Fikri, A. S.; Hishar, H.; Tamchek, N.; Taiman, K.; Ahmad Bazli, A. K.; Abdul-Rashid, H. A.; Mahdiraji, G. A.; Mizanur, R.; Noor, Noramaliza M.

    2013-05-01

    Cardiac positron emission tomography (PET) provides a precise method in order to diagnose obstructive coronary artery disease (CAD), compared to single photon emission tomography (SPECT). PET is suitable for obese and patients who underwent pharmacologic stress procedures. It has the ability to evaluate multivessel coronary artery disease by recording changes in left ventricular function from rest to peak stress and quantifying myocardial perfusion (in mL/min/g of tissue). However, the radiation dose to the radiosensitive organs has become crucial issues in the Positron Emission Tomography/Computed Tomography(PET/CT) scanning procedure. The objective of this study was to estimate radiation dose to radiosensitive organs of patients who underwent PET/CT myocardial perfusion examination at Centre for Diagnostic Nuclear Imaging, Universiti Putra Malaysia in one month period using versatile optical fibres (Ge-B-doped Flat Fibre) and LiF (TLD-100 chips). All stress and rest paired myocardial perfusion PET/CT scans will be performed with the use of Rubidium-82 (82Rb). The optic fibres were loaded into plastic capsules and attached to patient's eyes, thyroid and breasts prior to the infusion of 82Rb, to accommodate the ten cases for the rest and stress PET scans. The results were compared with established thermoluminescence material, TLD-100 chips. The result shows that radiation dose given by TLD-100 and Germanium-Boron-doped Flat Fiber (Ge-B-doped Flat Fiber) for these five organs were comparable to each other where the p>0.05. For CT scans,thyroid received the highest dose compared to other organs. Meanwhile, for PET scans, breasts received the highest dose.

  14. Principles of PET/MR Imaging.

    Science.gov (United States)

    Disselhorst, Jonathan A; Bezrukov, Ilja; Kolb, Armin; Parl, Christoph; Pichler, Bernd J

    2014-05-12

    Hybrid PET/MR systems have rapidly progressed from the prototype stage to systems that are increasingly being used in the clinics. This review provides an overview of developments in hybrid PET/MR systems and summarizes the current state of the art in PET/MR instrumentation, correction techniques, and data analysis. The strong magnetic field requires considerable changes in the manner by which PET images are acquired and has led, among others, to the development of new PET detectors, such as silicon photomultipliers. During more than a decade of active PET/MR development, several system designs have been described. The technical background of combined PET/MR systems is explained and related challenges are discussed. The necessity for PET attenuation correction required new methods based on MR data. Therefore, an overview of recent developments in this field is provided. Furthermore, MR-based motion correction techniques for PET are discussed, as integrated PET/MR systems provide a platform for measuring motion with high temporal resolution without additional instrumentation. The MR component in PET/MR systems can provide functional information about disease processes or brain function alongside anatomic images. Against this background, we point out new opportunities for data analysis in this new field of multimodal molecular imaging. PMID:24819419

  15. Diseases Transmitted by Less Common House Pets.

    Science.gov (United States)

    Chomel, Bruno B

    2015-12-01

    Beside dogs and cats, the most common pets worldwide, an increasing number of pocket pets and exotic pets are making their way to more and more households, especially in North America and Europe. Although many of these animals make appropriate pets, they also can be a source of many zoonotic diseases, especially in young children and immunocompromised individuals. Some of these diseases can be life threatening, such as rabies, rat bite fever, and plague. Some others are quite common, because of the frequency of the pathogens harbored by these species, such as salmonellosis in reptiles and amphibians. Appropriate knowledge of the zoonotic agents carried by these "new" pet species is strongly recommended prior to acquiring pocket or exotic pets. Furthermore, adopting wildlife as pets is strongly discouraged, because it is always a risky action that can lead to major health issues. PMID:27337276

  16. SPECT og PET i neurobiologien

    DEFF Research Database (Denmark)

    Paulson, O.B.; Lassen, N.A.

    1997-01-01

    PET (positron emission tomography) and SPECT (single photon emission computed tomography) are isotopic methods in which the distribution is registered of radiolabelled tracers given in such small amounts that they are without effect on the organism or the organism's disposal of them. Thus, a series...

  17. Particle Accelerators for PET radionuclides

    DEFF Research Database (Denmark)

    Jensen, Mikael

    2012-01-01

    The requirements set for particle accelerators for production of radioactive isotopes for PET can easily be derived from first principles. The simple general need is for proton beams with energy in the region 10–20 MeV and current 20–100 microAmps. This is most reliably and cost-effectively achie......The requirements set for particle accelerators for production of radioactive isotopes for PET can easily be derived from first principles. The simple general need is for proton beams with energy in the region 10–20 MeV and current 20–100 microAmps. This is most reliably and cost...... different manufacturers will be discussed the light of what is actually needed for a given PET site operation. Alternatives to the conventional cyclotron have been proposed and tested but have at present very limited use. These alternatives will be discussed, as well as the future possibilities of supplying...... point of demand tracer production with very small cyclotrons of energy well below 10 MeV. The authors best advice at present for new PET sites is to negotiate for conventional cyclotron solutions from experienced manufacturers. It is the combined performance of cyclotron and target in terms of available...

  18. Diagnostic imaging of exotic pets

    International Nuclear Information System (INIS)

    Radiographic, ultrasonographic, and computed tomographic (CT) imaging are important diagnostic modalities in exotic pets. The use of appropriate radiographic equipment, film-screen combinations, and radiographic projections enhances the information obtained from radiographs. Both normal findings and common radiographic abnormalities are discussed. The use of ultrasonography and CT scanning for exotic small mammals and reptiles is described

  19. PET and SPECT in psychiatry

    International Nuclear Information System (INIS)

    Covers classical psychiatric disorders as well as other subjects such as suicide, sleep, eating disorders, and autism. Emphasis on a multidisciplinary approach. Written by internationally acclaimed experts. PET and SPECT in Psychiatry showcases the combined expertise of renowned authors whose dedication to the investigation of psychiatric disease through nuclear medicine technology has achieved international recognition. The classical psychiatric disorders as well as other subjects - such as suicide, sleep, eating disorders, and autism - are discussed and the latest results in functional neuroimaging are detailed. Most chapters are written jointly by a clinical psychiatrist and a nuclear medicine expert to ensure a multidisciplinary approach. This state of the art compendium will be valuable to all who have an interest in the field of neuroscience, from the psychiatrist and the radiologist/nuclear medicine specialist to the interested general practitioner and cognitive psychologist. It is the first volume of a trilogy on PET and SPECT imaging in the neurosciences; other volumes will focus on PET and SPECT in neurology and PET and SPECT of neurobiological systems.

  20. PET and SPECT in psychiatry

    Energy Technology Data Exchange (ETDEWEB)

    Dierckx, Rudi A.J.O. [University Medical Center Groningen (Netherlands). Dept. of Nuclear Medicine and Molecular Imaging; Ghent Univ. (Belgium); Otte, Andreas [Univ. of Applied Sciences Offenburg (Germany). Faculty of Electrical Engineering and Information Technology; Vries, Erik F.J. de; Waarde, Aren van (eds.) [University Medical Center Groningen (Netherlands). Dept. of Nuclear Medicine and Molecular Imaging

    2014-09-01

    Covers classical psychiatric disorders as well as other subjects such as suicide, sleep, eating disorders, and autism. Emphasis on a multidisciplinary approach. Written by internationally acclaimed experts. PET and SPECT in Psychiatry showcases the combined expertise of renowned authors whose dedication to the investigation of psychiatric disease through nuclear medicine technology has achieved international recognition. The classical psychiatric disorders as well as other subjects - such as suicide, sleep, eating disorders, and autism - are discussed and the latest results in functional neuroimaging are detailed. Most chapters are written jointly by a clinical psychiatrist and a nuclear medicine expert to ensure a multidisciplinary approach. This state of the art compendium will be valuable to all who have an interest in the field of neuroscience, from the psychiatrist and the radiologist/nuclear medicine specialist to the interested general practitioner and cognitive psychologist. It is the first volume of a trilogy on PET and SPECT imaging in the neurosciences; other volumes will focus on PET and SPECT in neurology and PET and SPECT of neurobiological systems.

  1. {sup 18}F-FDG PET/CT impact on testicular tumours clinical management

    Energy Technology Data Exchange (ETDEWEB)

    Ambrosini, Valentina; Nicolini, Silvia; Nanni, Cristina; Allegri, Vincenzo; Fanti, Stefano [S.Orsola-Malpighi University Hospital, Nuclear Medicine, Bologna (Italy); Zucchini, Giorgia; Berselli, Annalisa; Martoni, Andrea; Cricca, Antonia [S.Orsola-Malpighi University Hospital, Oncology, Bologna (Italy); Domenico, Rubello [S.Maria della Misericordia Hospital, Nuclear Medicine, Rovigo (Italy)

    2014-04-15

    Testicular tumour is the most common malignancy in young men. The diagnostic work-up is mainly based on morphological imaging. The aim of our study was to evaluate the clinical impact of {sup 18}F-FDG PET/CT in patients with testicular tumour. We retrospectively evaluated all patients studied by {sup 18}F-FDG PET/CT at our centre. Inclusion criteria were: pathological confirmation of testicular tumour, contrast-enhanced CT scan performed within a month of the PET/CT scan, and clinical/imaging follow-up performed at the Oncology Unit of our hospital. Overall, 56 patients were enrolled and 121 PET/CT scans were evaluated. {sup 18}F-FDG PET/CT was performed following standard procedures and the results were compared with clinical, imaging and follow-up data. Clinicians were contacted to enquire whether the PET/CT scan influenced the patient's management. Answers were scored as follows: start/continue chemotherapy or radiotherapy, indication for surgery of secondary lesions, and clinical surveillance. On a scan basis, 51 seminoma and 70 nonseminoma (NS) cases were reviewed. Of the 121 cases. 32 were found to be true-positive, 74 true-negative, 8 false-positive and 6 false-negative by PET/CT. PET/CT showed good sensitivity and specificity for seminoma lesion detection (92 % and 84 %, respectively), but its sensitivity was lower for NS forms (sensitivity and specificity 77 % and 95 %, respectively). The PET/CT scan influenced the clinical management of 47 of 51 seminomas (in 6 chemotherapy was started/continued, in 3 radiotherapy was started/continued, in 2 surgery of secondary lesions was performed, and in 36 clinical surveillance was considered appropriate), and 59 of 70 NS (in 18 therapy/surgery was started/continued, and in 41 clinical surveillance was considered appropriate). Our preliminary data demonstrate the potential usefulness of PET/CT for the assessment of patients with testicular tumour. It provides valuable information for the clinical management

  2. Pet insurance--essential option?

    Science.gov (United States)

    Stowe, J D

    2000-08-01

    As Hawn (2) says, "insurance is about risk and peace of mind." She reports that the American Humane Society supports pet insurance because companion animals are able to be treated for disease or accidents that are life-threatening where, otherwise, they would have been euthanized. For veterinarians, she suggests that pet insurance allows them to practice veterinary medicine "as if it were free." It is inevitable that pet insurance will grow as a recourse for veterinary fees. This may be a savior to some families whose budget is stretched to the limit at a critical moment in the health care of their cherished pet. We in the veterinary profession have an advantage over other professions. We have seen the good, the bad, and the ugly of insurance, as it applies to human health and dental care. If we work hand-in-hand with our own industries, collectively we may be able to develop a system that wins for everyone, with fees that allow practice to thrive and growth strategies that accommodate new treatment and diagnostic modalities, as well as consistent and exemplary customer service. The path ahead is always fraught with bumps and potholes. We can be a passive passenger and become a victim of the times or an active driver to steer the profession to a clearer route. Pet insurance is but one of the solutions for the profession; the others are a careful assessment of our fees--charging what we are worth, not what we think the client will pay; business management; customer service; leadership of our health care team; lifelong learning; and more efficient delivery systems. Let us stop being a victim, stop shooting ourselves in the professional foot, and seize the day! PMID:10945132

  3. The INTEGRAL Science Data Centre

    OpenAIRE

    Beckmann, V.

    2002-01-01

    The INTEGRAL Science Data Centre (ISDC) processes, archives and distributes data from the INTEGRAL mission. At the ISDC incoming data from the satellite are processed and searched for transient sources and Gamma-Ray bursts. The data are archived and distributed to the guest observers. As soon as the data are public, any astronomer can access the data via the internet. ISDC also provides the tools which are necessary for the data analysis and offers user support concerning questions related to...

  4. Radwaste Treatment Centre Jaslovske Bohunice

    International Nuclear Information System (INIS)

    In this leaflet the Bohunice Radwaste Treatment Centre (BSC RAO) is presented. BSC RAO is designed to process and treat liquid and solid radwaste, arising from the NPP A-1 decommissioning, from NPPs V-1, V-2, and Mochovce operations, as well as institutional radwaste of diverse institutional (hospitals, research institutes) in the Slovak Republic. Transport, sorting, incineration, compacting, concentration and cementation of radwaste as well as monitoring of emission are described

  5. 75 FR 76699 - The University of Texas at Austin, et al.; Notice of Decision on Applications for Duty-Free Entry...

    Science.gov (United States)

    2010-12-09

    .... Manufacturer: ADS International, S.r.l., Italy. Intended Use: See notice at 75 FR 67949, November 4, 2010...: 10-064. Applicant: The University of Texas at Austin, Center for Electromechanics, Pickle Research... because of its ability to achieve the desired accuracy of +/-2 microns, the stiffness of 400 N/micron,...

  6. PET in cerebrovascular disease; PET bei zerebrovaskulaeren Erkrankungen

    Energy Technology Data Exchange (ETDEWEB)

    Herholz, K. [Neurologische Universitaetsklinik der Univ. Koeln (Germany)]|[Max-Planck-Institut fuer Neurologische Forschung, Koeln (Germany)

    1997-03-01

    Tissue viability is of particular interest in acute cerebral ischemia because it may be preserved if reperfusion can be achieved rapidly, e.g. by acute thrombolysis. Measurements of regional cerebral blood flow (CBF) and oxygen consumption by PET can assess tissue viability, and they have substantially increased our knowledge of th pathophysiology of ischemic stroke and the associated penumbra. Widerspread clinical application in acute stroke, however, is unlikely because of the large logistic and personnel resources required. In chronic cerebrovascular disease, measurement of regional CBF and glucose metabolism, which is usually coupled, provide detailed insights in disturbance of cortical function, e.g. due to deafferentiation, and contribute to differentiation of dementia types. Chronic misery perfusion, i.e. reduced perfusion that does not match the metabolic demand of the tissue, can be demonstrated by PET. It may be found in some patients with high-grade arterial stenoses. Less severe impairment of brain perfusion can be demonstrated by measurement of the cerebrovascular reserve capacity. The most frequent clinical situations can be assessed by less demanding procedures, e.g. by SPECT. In conclusion, PET has its role in cerebrovascular disease primarily within scientific studies, where high resolution and absolute quantitation of physiological variables are essential. (orig.). 65 refs. [Deutsch] Beim akuten ischaemischen Insult ist die Vitalitaet des Gewebes von besonderem Interesse, da sie durch rasche Reperfusion, z.B. durch Thrombolyse, erhalten bleiben kann. Messungen der zerebralen Durchblutung und des Sauerstoffumsatzes mittels PET geben darueber wesentliche Aufschluesse, und sie sind wichtig fuer das Verstaendnis der Pathophysiologie ischaemischer Infarkte und der Penumbra mit kritischer Perfusion beim Menschen. Ihre breitere Anwendung in der klinischen Patientenversorgung kommt allerdings wegen des hohen Aufwandes derzeit kaum in Betracht. Bei

  7. The Notting Dale Urban Studies Centre

    Science.gov (United States)

    Webb, Chris; Lynas, Sue

    1976-01-01

    Founded in 1974, the Centre is one of the most intensively used resource centres in the United Kingdom. Adults and students from elementary to college level use its facilities to learn about the urban environment. (BD)

  8. Simulation of a two-pollutant, two-season pollution offset system for the Colorado River of Texas below Austin

    Science.gov (United States)

    Letson, David

    1992-05-01

    A pollution offset system is a discharge permit system in which transfers are made subject to a restriction that no violations of water quality standards occur at any location. Simulation of a pollution offset system with seasonal variation and multiple pollutants allows for comparison of the savings possible from these design features. A simulation model (Qual-TX) developed by the Texas Water Commission is applied to a case study region near Austin, Texas, yielding impact coefficients for an economic optimization model without investment whose least cost solution represents the theoretical equilibrium of a pollution offset system. The optimization model finds short-run savings of 17.5% for a pollution offset system, as compared to a command and control policy that would also achieve the dissolved oxygen standard. Seasonal variation in permit design produces minimal effects; virtually all savings come from allowing pollution offsets for the two different pollutants.

  9. Present and future aspects of PET examinations

    International Nuclear Information System (INIS)

    The PET examination gives the body distribution image of a compound labeled with the positron emitter manufactured by cyclotron. Recently, PET with F18-deoxyglucose (FDG) attracts considerable attention because the imaging is particularly useful for cancer detection. Since the technique was authorized by the United States (US) official health insurance in 1998, the number of the examination is increasing, which is also under similar situation in Japan due to the latest partial authorization for some malignant tumors. In Japan, about 30,000 examinations per year are carried out, half of which, in private hospitals. Their purpose is increasingly for cancer detection. For future PET examination, awaited are improvement of PET camera and development of a novel imaging agent. PET/CT imaging is for the former and F18-α-methyltyrosine, for the latter. Miniaturization of cyclotron, FDG delivery system, improved FDG synthetic method, popularization of PET/CT, development of PET camera for health examination, clinical trial of a novel imaging agent, and spread of PET health examination and operation of PET Center, are expected for future progress of PET technique. (N.I.)

  10. PET/MRI and PET/CT in advanced gynaecological tumours: initial experience and comparison

    Energy Technology Data Exchange (ETDEWEB)

    Queiroz, Marcelo A.; Schulthess, Gustav von; Veit-Haibach, Patrick [University Hospital Zurich, Department Medical Radiology, Nuclear Medicine, Zurich (Switzerland); University Hospital Zurich, Department Medical Radiology, Diagnostic and Interventional Radiology, Zurich (Switzerland); University of Zurich, Zurich (Switzerland); Kubik-Huch, Rahel A.; Freiwald-Chilla, Bianka [Kantonsspital Baden AG, Department of Radiology, Baden (Switzerland); Hauser, Nik [Kantonsspital Baden AG, Department of Gynaecology, Baden (Switzerland); Froehlich, Johannes M. [Guerbet AG, Zurich (Switzerland)

    2015-08-15

    To compare the diagnostic accuracy of PET/MRI and PET/CT for staging and re-staging advanced gynaecological cancer patients as well as identify the potential benefits of each method in such a population. Twenty-six patients with suspicious or proven advanced gynaecological cancer (12 ovarian, seven cervical, one vulvar and four endometrial tumours, one uterine metastasis, and one primary peritoneal cancer) underwent whole-body imaging with a sequential trimodality PET/CT/MR system. Images were analysed regarding primary tumour detection and delineation, loco-regional lymph node staging, and abdominal/extra-abdominal distant metastasis detection (last only by PET/CT). Eighteen (69.2 %) patients underwent PET/MRI for primary staging and eight patients (30.8 %) for re-staging their gynaecological malignancies. For primary tumour delineation, PET/MRI accuracy was statistically superior to PET/CT (p < 0.001). Among the different types of cancer, PET/MRI presented better tumour delineation mainly for cervical (6/7) and endometrial (2/3) cancers. PET/MRI for local evaluation as well as PET/CT for extra-abdominal metastases had therapeutic consequences in three and one patients, respectively. PET/CT detected 12 extra-abdominal distant metastases in 26 patients. PET/MRI is superior to PET/CT for primary tumour delineation. No differences were found in detection of regional lymph node involvement and abdominal metastases detection. (orig.)

  11. Basic study of entire whole-body PET scanners based on the OpenPET geometry

    Energy Technology Data Exchange (ETDEWEB)

    Yoshida, Eiji, E-mail: rush@nirs.go.j [National Institute of Radiological Sciences, 4-9-1 Inage-ku, Chiba 263-8555 (Japan); Yamaya, Taiga; Nishikido, Fumihiko; Inadama, Naoko; Murayama, Hideo [National Institute of Radiological Sciences, 4-9-1 Inage-ku, Chiba 263-8555 (Japan)

    2010-09-21

    A conventional PET scanner has a 15-25 cm axial field-of-view (FOV) and images a whole body using about six bed positions. An OpenPET geometry can extend the axial FOV with a limited number of detectors. The entire whole-body PET scanner must be able to process a large amount of data effectively. In this work, we study feasibility of the fully 3D entire whole-body PET scanner using the GATE simulation. The OpenPET has 12 block detector rings with the ring diameter of 840 mm and each block detector ring consists of 48 depth-of-interaction (DOI) detectors. The OpenPET has the axial length of 895.95 mm with five parts of 58.95 mm open gaps. The OpenPET has higher single data loss than a conventional PET scanner at grouping circuits. NECR of the OpenPET decreases by single data loss. But single data loss is mitigated by separating the axially arranged detector into two parts. Also, multiple coincidences are found to be important for the entire whole-body PET scanner. The entire whole-body PET scanner with the OpenPET geometry promises to provide a large axial FOV with the open space and to have sufficient performance values. But single data loss at the grouping circuits and multiple coincidences are limited to the peak noise equivalent count rate (NECR) for the entire whole-body PET scanner.

  12. Clinical Application of {sup 18}F-FDG PET and PET-CT in Adrenal Tumor

    Energy Technology Data Exchange (ETDEWEB)

    Hwang, Kyung Hoon; Choi, Duck Joo; Lee, Min Kyung; Choe, Won Sick [Gachon University Gil Hospital, Incheon (Korea, Republic of)

    2008-12-15

    Adrenal tumors are increasingly detected by widespread use of anatomical imaging such as CT, MRI, etc. For these adrenal tumors, differentiation between malignancy and benignancy is very important. In diagnostic assessment of adrenal tumor, {sup 18}F-FDG PET and PET-CT have been reported to have high diagnostic performance, especially, very excellent performance in evaluation of adrenal metastasis in the oncologic patient. In cases of adrenal incidentalomas, {sup 18}F-FDG PET or PET-CT is helpful if CT or chemical-shift MRI is inconclusive. {sup 18}F-FDG PET and PET-CT may be applied to the patients with MIBG-negative pheochromocytomas. In summary, {sup 18}F-FDG PET and PET-CT are expected to be effective diagnostic tools in the management of adrenal tumor.

  13. FDG PET and PET/CT: EANM procedure guidelines for tumour PET imaging: version 1.0

    DEFF Research Database (Denmark)

    Boellaard, Ronald; O'Doherty, Mike J; Weber, Wolfgang A;

    2010-01-01

    The aim of this guideline is to provide a minimum standard for the acquisition and interpretation of PET and PET/CT scans with [18F]-fluorodeoxyglucose (FDG). This guideline will therefore address general information about[18F]-fluorodeoxyglucose (FDG) positron emission tomography......-computed tomography (PET/CT) and is provided to help the physician and physicist to assist to carrying out,interpret, and document quantitative FDG PET/CT examinations,but will concentrate on the optimisation of diagnostic quality and quantitative information....

  14. Scheduling participants of Assessment Centres

    DEFF Research Database (Denmark)

    Lysgaard, Jens; Løber, Janni

      Assessment Centres are used as a tool for psychologists and coaches to observe a number of dimensions in a person's behaviour and test his/her potential within a number of chosen focus areas. This is done in an intense course, with a number of different exercises which expose each participant......'s ability level in the chosen focus areas. The participants are observed by assessors with the purpose of gathering material for reaching a conclusion on each participant's personal profile. We consider the particular case that arises at the company Human Equity (www.humanequity.dk), where Assessment...

  15. PET/MRI in cancer patients

    DEFF Research Database (Denmark)

    Kjær, Andreas; Loft, Annika; Law, Ian;

    2013-01-01

    Combined PET/MRI systems are now commercially available and are expected to change the medical imaging field by providing combined anato-metabolic image information. We believe this will be of particular relevance in imaging of cancer patients. At the Department of Clinical Physiology, Nuclear...... described include brain tumors, pediatric oncology as well as lung, abdominal and pelvic cancer. In general the cases show that PET/MRI performs well in all these types of cancer when compared to PET/CT. However, future large-scale clinical studies are needed to establish when to use PET/MRI. We envision...... that PET/MRI in oncology will prove to become a valuable addition to PET/CT in diagnosing, tailoring and monitoring cancer therapy in selected patient populations....

  16. Critical Care of Pet Birds.

    Science.gov (United States)

    Jenkins, Jeffrey Rowe

    2016-05-01

    Successful care of the critical pet bird patient is dependent on preparation and planning and begins with the veterinarian and hospital staff. An understanding of avian physiology and pathophysiology is key. Physical preparation of the hospital or clinic includes proper equipment and understanding of the procedures necessary to provide therapeutic and supportive care to the avian patient. An overview of patient intake and assessment, intensive care environment, and fluid therapy is included. PMID:27131161

  17. Pet Store Loyalty in Malaysia

    OpenAIRE

    Leong, Yuen Yee

    2010-01-01

    Loyalty is open studied topic within the retailing and marketing discipline. A strong and profitable base of loyal customers is an asset to any organization, and is one of the epitomes of success for a company. The flourishing of large, specialty niche retailers like Starbucks, Victoria Secret and Barnes & Noble are stellar success stories that thrive on their troop of staunch followers. Pet retailing is a niche market which has its own interesting market characteristics. The emergence of ...

  18. Joint PET-MR respiratory motion models for clinical PET motion correction

    Science.gov (United States)

    Manber, Richard; Thielemans, Kris; Hutton, Brian F.; Wan, Simon; McClelland, Jamie; Barnes, Anna; Arridge, Simon; Ourselin, Sébastien; Atkinson, David

    2016-09-01

    Patient motion due to respiration can lead to artefacts and blurring in positron emission tomography (PET) images, in addition to quantification errors. The integration of PET with magnetic resonance (MR) imaging in PET-MR scanners provides complementary clinical information, and allows the use of high spatial resolution and high contrast MR images to monitor and correct motion-corrupted PET data. In this paper we build on previous work to form a methodology for respiratory motion correction of PET data, and show it can improve PET image quality whilst having minimal impact on clinical PET-MR protocols. We introduce a joint PET-MR motion model, using only 1 min per PET bed position of simultaneously acquired PET and MR data to provide a respiratory motion correspondence model that captures inter-cycle and intra-cycle breathing variations. In the model setup, 2D multi-slice MR provides the dynamic imaging component, and PET data, via low spatial resolution framing and principal component analysis, provides the model surrogate. We evaluate different motion models (1D and 2D linear, and 1D and 2D polynomial) by computing model-fit and model-prediction errors on dynamic MR images on a data set of 45 patients. Finally we apply the motion model methodology to 5 clinical PET-MR oncology patient datasets. Qualitative PET reconstruction improvements and artefact reduction are assessed with visual analysis, and quantitative improvements are calculated using standardised uptake value (SUVpeak and SUVmax) changes in avid lesions. We demonstrate the capability of a joint PET-MR motion model to predict respiratory motion by showing significantly improved image quality of PET data acquired before the motion model data. The method can be used to incorporate motion into the reconstruction of any length of PET acquisition, with only 1 min of extra scan time, and with no external hardware required.

  19. Validation of peneloPET simulations of the Biograph PET/CT scanner with TOF capabilities

    OpenAIRE

    Abushab, K. M.; Herraiz, J. L.; Vicente, E.; España, Samuel; Vaquero, Juan José; Udías, José Manuel

    2010-01-01

    Monte Carlo simulations are currently widely used in positron emission tomography (PET) imaging for optimizing detector design and acquisition protocols, and for developing and assessing corrections and reconstruction methods. PeneloPET is a Monte Carlo code for PET simulations with basic components of detector geometry, acquisition electronics and material and source definitions. The purpose of the present study was to validate the simulations of the Siemens Biograph PET/CT scanner with TOF ...

  20. Joint PET-MR respiratory motion models for clinical PET motion correction.

    Science.gov (United States)

    Manber, Richard; Thielemans, Kris; Hutton, Brian F; Wan, Simon; McClelland, Jamie; Barnes, Anna; Arridge, Simon; Ourselin, Sébastien; Atkinson, David

    2016-09-01

    Patient motion due to respiration can lead to artefacts and blurring in positron emission tomography (PET) images, in addition to quantification errors. The integration of PET with magnetic resonance (MR) imaging in PET-MR scanners provides complementary clinical information, and allows the use of high spatial resolution and high contrast MR images to monitor and correct motion-corrupted PET data. In this paper we build on previous work to form a methodology for respiratory motion correction of PET data, and show it can improve PET image quality whilst having minimal impact on clinical PET-MR protocols. We introduce a joint PET-MR motion model, using only 1 min per PET bed position of simultaneously acquired PET and MR data to provide a respiratory motion correspondence model that captures inter-cycle and intra-cycle breathing variations. In the model setup, 2D multi-slice MR provides the dynamic imaging component, and PET data, via low spatial resolution framing and principal component analysis, provides the model surrogate. We evaluate different motion models (1D and 2D linear, and 1D and 2D polynomial) by computing model-fit and model-prediction errors on dynamic MR images on a data set of 45 patients. Finally we apply the motion model methodology to 5 clinical PET-MR oncology patient datasets. Qualitative PET reconstruction improvements and artefact reduction are assessed with visual analysis, and quantitative improvements are calculated using standardised uptake value (SUV(peak) and SUV(max)) changes in avid lesions. We demonstrate the capability of a joint PET-MR motion model to predict respiratory motion by showing significantly improved image quality of PET data acquired before the motion model data. The method can be used to incorporate motion into the reconstruction of any length of PET acquisition, with only 1 min of extra scan time, and with no external hardware required. PMID:27524409

  1. Multifocal Head and Neck Paraganglioma Evaluated with Different PET Tracers: Comparison Between Fluorine-18-Fluorodeoxyglucose Between Fluorine-18-Fluorodeoxyglucose and Gallium-68-Somatostatin Receptor PET/CT

    Energy Technology Data Exchange (ETDEWEB)

    Castaldi, Paola; Rufini, Vittoria [Catholic Univ. of the Sacred Heart, Rome (Italy); Treglia, G. [Oncology Institute of Southern Switzerland, Bellinzona (Switzerland)

    2013-09-15

    We report the case of a 46-year-old woman with a succinate dehydrogenase subtype D (SDHD) gene mutation and multifocal head and neck paraganglioma evaluated with fluorine-18-fluorodeoxyglucose and gallium-68-somatostatin receptor positron emission tomography/computed tomography (PET/CT). Gallium-68-somatostatin receptor PET/CT correctly assessed the extent of the disease in this patient, detecting additional lesions compared with fluorine-18-fluorodeoxyglucose PET/CT and influencing the patient management. A 46-year-old woman was referred to our centre for surveillance of a gastrointestinal stromal tumour (GIST). The patient underwent fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography (F-18-FDG-PET/CT), which demonstrated a focal area of increased radiopharmaceutical uptake corresponding to a lesion located between the right carotid vessels (yellow arrow; Fig. 1a). This F-18-FDG-PET/CT finding was suspicious for a paraganglioma of the neck. The patient underwent further examinations, including biochemical and genetic tests and a somatostatin receptor PET/CT using somatostatin analogues labelled with gallium-68 (Ga-68-DOTANOC-PET/CT). Laboratory data were suspicious for a non-functioning neuroendocrine tumour. Increased serum chromogranin A value and normal values of plasmatic and urinary catecholamines and their metabolites were found. The patient had no symptoms of a functioning tumour. Genetic tests demonstrated the presence of a succinate dehydrogenase subtype D (SDHD) gene mutation, which is associated with head and neck paragangliomas. Surprisingly, Ga-68-DOTANOC-PET/CT (Fig. 1b) showed multiple bilateral areas of increased radiopharmaceutical uptake in the head and neck region, corresponding to bilateral neuroendocrine lesions and suggesting the presence of bilateral paragangliomas (yellow arrows) with small cervical lymph nodal metastases with short axis less than 1 cm of diameter (red arrows). Physiological radiopharmaceutical

  2. Multifocal Head and Neck Paraganglioma Evaluated with Different PET Tracers: Comparison Between Fluorine-18-Fluorodeoxyglucose Between Fluorine-18-Fluorodeoxyglucose and Gallium-68-Somatostatin Receptor PET/CT

    International Nuclear Information System (INIS)

    We report the case of a 46-year-old woman with a succinate dehydrogenase subtype D (SDHD) gene mutation and multifocal head and neck paraganglioma evaluated with fluorine-18-fluorodeoxyglucose and gallium-68-somatostatin receptor positron emission tomography/computed tomography (PET/CT). Gallium-68-somatostatin receptor PET/CT correctly assessed the extent of the disease in this patient, detecting additional lesions compared with fluorine-18-fluorodeoxyglucose PET/CT and influencing the patient management. A 46-year-old woman was referred to our centre for surveillance of a gastrointestinal stromal tumour (GIST). The patient underwent fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography (F-18-FDG-PET/CT), which demonstrated a focal area of increased radiopharmaceutical uptake corresponding to a lesion located between the right carotid vessels (yellow arrow; Fig. 1a). This F-18-FDG-PET/CT finding was suspicious for a paraganglioma of the neck. The patient underwent further examinations, including biochemical and genetic tests and a somatostatin receptor PET/CT using somatostatin analogues labelled with gallium-68 (Ga-68-DOTANOC-PET/CT). Laboratory data were suspicious for a non-functioning neuroendocrine tumour. Increased serum chromogranin A value and normal values of plasmatic and urinary catecholamines and their metabolites were found. The patient had no symptoms of a functioning tumour. Genetic tests demonstrated the presence of a succinate dehydrogenase subtype D (SDHD) gene mutation, which is associated with head and neck paragangliomas. Surprisingly, Ga-68-DOTANOC-PET/CT (Fig. 1b) showed multiple bilateral areas of increased radiopharmaceutical uptake in the head and neck region, corresponding to bilateral neuroendocrine lesions and suggesting the presence of bilateral paragangliomas (yellow arrows) with small cervical lymph nodal metastases with short axis less than 1 cm of diameter (red arrows). Physiological radiopharmaceutical

  3. FDG-PET imaging in hematological malignancies.

    Science.gov (United States)

    Valls, L; Badve, C; Avril, S; Herrmann, K; Faulhaber, P; O'Donnell, J; Avril, N

    2016-07-01

    The majority of aggressive lymphomas is characterized by an up regulated glycolytic activity, which enables the visualization by F-18 FDG-PET/CT. One-stop hybrid FDG-PET/CT combines the functional and morphologic information, outperforming both, CT and FDG-PET as separate imaging modalities. This has resulted in several recommendations using FDG-PET/CT for staging, restaging, monitoring during therapy, and assessment of treatment response as well as identification of malignant transformation. FDG-PET/CT may obviate the need for a bone marrow biopsy in patients with Hodgkin's lymphoma and diffuse large B cell lymphoma. FDG-PET/CT response assessment is recommended for FDG-avid lymphomas, whereas CT-based response evaluation remains important in lymphomas with low or variable FDG avidity. The treatment induced change in metabolic activity allows for assessment of response after completion of therapy as well as prediction of outcome early during therapy. The five-point scale Deauville Criteria allows the assessment of treatment response based on visual FDG-PET analysis. Although the use of FDG-PET/CT for prediction of therapeutic response is promising it should only be conducted in the context of clinical trials. Surveillance FDG-PET/CT after complete remission is discouraged due to the relative high number of false-positive findings, which in turn may result in further unnecessary investigations. Future directions include the use of new PET tracers such as F-18 fluorothymidine (FLT), a surrogate biomarker of cellular proliferation and Ga-68 CXCR4, a chemokine receptor imaging biomarker as well as innovative digital PET/CT and PET/MRI techniques. PMID:27090170

  4. PET-CT imaging in pediatric oncology

    OpenAIRE

    McCarville, M. Beth

    2009-01-01

    Abstract Positron emission tomography (PET)-computed tomography (CT) is emerging as a valuable tool for assessing a wide variety of pediatric malignancies, including lymphomas, soft-tissue tumors, and bone sarcomas. PET-CT may provide information that is not apparent on conventional imaging performed to stage these diseases and monitor their response to treatment. The use of PET-CT in children requires an awareness of the technical and logistical issues unique to this patient population. In a...

  5. PET/MR: a paradigm shift

    OpenAIRE

    Gaertner, Florian C.; Furst, Sebastian; Schwaiger, Markus

    2013-01-01

    Abstract More than a decade ago, multimodality imaging was introduced into clinical routine with the development of the positron emission tomography (PET)/computed tomography (CT) technique. Since then, PET/CT has been widely accepted in clinical imaging and has emerged as one of the main cancer imaging modalities. With the recent development of combined PET/magnetic resonance (MR) systems for clinical use, a promising new hybrid imaging modality is now becoming increasingly available. The co...

  6. Pet Ownership and Evacuation Prior to Hurricane Irene.

    Science.gov (United States)

    Hunt, Melissa G; Bogue, Kelsey; Rohrbaugh, Nick

    2012-01-01

    Pet ownership has historically been one of the biggest risk factors for evacuation failure prior to natural disasters. The forced abandonment of pets during Hurricane Katrina in 2005 made national headlines and led to the passage of the Pet Evacuation and Transportation Standards Act (PETS, 2006) which mandated local authorities to plan for companion animal evacuation. Hurricane Irene hit the East Coast of the United States in 2011, providing an excellent opportunity to examine the impact of the PETS legislation on frequency and ease of evacuation among pet owners and non-pet owners. Ninety pet owners and 27 non-pet owners who lived in mandatory evacuation zones completed questionnaires assessing their experiences during the hurricane and symptoms of depression, PTSD, dissociative experiences, and acute stress. Pet ownership was not found to be a statistical risk factor for evacuation failure. However, many pet owners who failed to evacuate continue to cite pet related reasons. PMID:26487162

  7. Pet Ownership and Evacuation Prior to Hurricane Irene

    Directory of Open Access Journals (Sweden)

    Nick Rohrbaugh

    2012-09-01

    Full Text Available Pet ownership has historically been one of the biggest risk factors for evacuation failure prior to natural disasters. The forced abandonment of pets during Hurricane Katrina in 2005 made national headlines and led to the passage of the Pet Evacuation and Transportation Standards Act (PETS, 2006 which mandated local authorities to plan for companion animal evacuation. Hurricane Irene hit the East Coast of the United States in 2011, providing an excellent opportunity to examine the impact of the PETS legislation on frequency and ease of evacuation among pet owners and non-pet owners. Ninety pet owners and 27 non-pet owners who lived in mandatory evacuation zones completed questionnaires assessing their experiences during the hurricane and symptoms of depression, PTSD, dissociative experiences, and acute stress. Pet ownership was not found to be a statistical risk factor for evacuation failure. However, many pet owners who failed to evacuate continue to cite pet related reasons.

  8. Interests of the PET with 18-F.D.G. in infectious pathology: about a case of systemic candidiasis; Interets de la TEP au 18-FDG en pathologie infectieuse: a propos d'un cas de candidose systemique

    Energy Technology Data Exchange (ETDEWEB)

    Avet, J.; Granjon, D.; Prevot, N.; Isnardi, V.; Dubois, F. [Service de medecine nucleaire, CHU de Saint-etienne, (France); Stephan, J.L.; Berger, C. [service de pediatrie, CHU de Saint-etienne, (France)

    2009-05-15

    We report the interest of the PET with {sup 18}F-F.D.G. in the extension evaluation of injuries and in the therapy decision for a patient suffering of a systemic candida. Conclusions: In spite of a lack of recommendations, because of its great sensitivity for the deep infectious centres detection, the PET with {sup 18}F-F.D.G. can bring useful information to the management and follow up of the systemic infections. (N.C.)

  9. Core Competencies Of A Call Centre AgentCore Competencies Of A Call Centre Agent

    OpenAIRE

    Christine White; Vera Roos

    2005-01-01

    Call centre agents are becoming increasingly important in the call centre context. They act as a contact point between the customer and the company. Call centre agents should have certain competencies to perform their duties sufficiently. Identifying competencies, required to be effective agents, will ease the task of training and recruitment. Due to the interrelatedness of the call centre agent, the management of a call centre and customers, all relevant role players’ perceptions were taken ...

  10. 18F-DOPA PET/CT in the diagnosis and localization of persistent medullary thyroid carcinoma

    International Nuclear Information System (INIS)

    To evaluate the performance of 18F-l-dihydroxyphenylalanine (18F-DOPA) PET/CT in the detection of locoregional and distant medullary thyroid carcinoma (MTC) metastases and to compare imaging findings with histological data. We retrospectively evaluated 86 MTC patients with persistently high serum calcitonin levels after initial surgery who had undergone 18F-DOPA PET/CT between January 2007 and December 2014 in two referral centres. They were followed up for at least 6 months after the PET/CT assessment. The results were compared with histological data or with the findings obtained during follow-up using a complementary imaging modality. 18F-DOPA PET/CT was positive in 65 of the 86 patients, corresponding to a patient-based sensitivity of 75.6 %. Distant metastatic disease (M1) was seen in 29 patients including 11 with previously unknown metastases revealed only by PET/CT. Among the 36 patients without distant metastatic spread, 25 had nodal involvement limited to the neck, and 10 of these 25 patients underwent reoperation. The lymph node compartment-based sensitivity of 18F-DOPA PET/CT was 100 % in the two institutions but lesion-based sensitivity was only 24 %. Preoperative and postoperative median calcitonin levels were 405 pg/mL (range 128 - 1,960 pg/mL) and 259 pg/mL (range 33 - 1,516 pg/mL), respectively. None of the patients achieved normalization of serum calcitonin after reoperation. 18F-DOPA PET/CT enables early diagnosis of a significant number of patients with distant metastasis. It has a limited sensitivity in the detection of residual disease but provides high performance for regional analysis. A surgical compartment-oriented approach could be the approach of choice whatever the number of nodes revealed by 18F-DOPA PET/CT. (orig.)

  11. {sup 18}F-DOPA PET/CT in the diagnosis and localization of persistent medullary thyroid carcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Archier, Aurelien; Mundler, Olivier [Aix-Marseille University, Department of Nuclear Medicine, La Timone University Hospital, Marseille (France); Aix-Marseille University, European Center for Research in Medical Imaging, Marseille (France); Heimburger, Celine [University Hospitals of Strasbourg, Department of Biophysics and Nuclear Medicine, Strasbourg (France); Guerin, Carole; Palazzo, Fausto F.; Henry, Jean-Francois; Sebag, Frederic [Aix-Marseille University, Department of Endocrine Surgery, Conception Hospital, Marseille (France); Morange, Isabelle [Aix-Marseille University, Department of Endocrinology, Conception Hospital, Marseille (France); Schneegans, Olivier [Paul Strauss Cancer Center, Department of Nuclear Medicine, Strasbourg (France); Abdullah, Ahmad Esmaeel [Aix-Marseille University, Department of Nuclear Medicine, La Timone University Hospital, Marseille (France); Imperiale, Alessio [University Hospitals of Strasbourg, Department of Biophysics and Nuclear Medicine, Strasbourg (France); ICube, UMR 7357 University of Strasbourg/CNRS and FMTS, Faculty of Medicine, Strasbourg (France); Taieb, David [Aix-Marseille University, Department of Nuclear Medicine, La Timone University Hospital, Marseille (France); Aix-Marseille University, European Center for Research in Medical Imaging, Marseille (France); Institut Paoli-Calmettes, Inserm UMR1068 Marseille Cancerology Research Center, Marseille (France)

    2016-06-15

    To evaluate the performance of {sup 18}F-l-dihydroxyphenylalanine ({sup 18}F-DOPA) PET/CT in the detection of locoregional and distant medullary thyroid carcinoma (MTC) metastases and to compare imaging findings with histological data. We retrospectively evaluated 86 MTC patients with persistently high serum calcitonin levels after initial surgery who had undergone {sup 18}F-DOPA PET/CT between January 2007 and December 2014 in two referral centres. They were followed up for at least 6 months after the PET/CT assessment. The results were compared with histological data or with the findings obtained during follow-up using a complementary imaging modality. {sup 18}F-DOPA PET/CT was positive in 65 of the 86 patients, corresponding to a patient-based sensitivity of 75.6 %. Distant metastatic disease (M1) was seen in 29 patients including 11 with previously unknown metastases revealed only by PET/CT. Among the 36 patients without distant metastatic spread, 25 had nodal involvement limited to the neck, and 10 of these 25 patients underwent reoperation. The lymph node compartment-based sensitivity of {sup 18}F-DOPA PET/CT was 100 % in the two institutions but lesion-based sensitivity was only 24 %. Preoperative and postoperative median calcitonin levels were 405 pg/mL (range 128 - 1,960 pg/mL) and 259 pg/mL (range 33 - 1,516 pg/mL), respectively. None of the patients achieved normalization of serum calcitonin after reoperation. {sup 18}F-DOPA PET/CT enables early diagnosis of a significant number of patients with distant metastasis. It has a limited sensitivity in the detection of residual disease but provides high performance for regional analysis. A surgical compartment-oriented approach could be the approach of choice whatever the number of nodes revealed by {sup 18}F-DOPA PET/CT. (orig.)

  12. The impact of 18F-FDG PET on the management of patients with suspected large vessel vasculitis

    International Nuclear Information System (INIS)

    We aimed to assess the impact of 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) on the management of patients with suspected large vessel vasculitis. An international expert panel determined diagnoses and clinical management in patients with suspected large vessel vasculitis, with and without the results of 18F-FDG PET, respectively. The accuracy of the clinical diagnosis and the resulting clinical management with and without the 18F-FDG PET results were compared using logistic regression models. The analysis included 30 patients referred to a tertiary care centre with large vessel vasculitis and 31 controls. 18F-FDG PET had an overall sensitivity of 73.3% [95% confidence interval (CI) 54.1-87.7%], a specificity of 83.9% (95% CI 66.3-94.5%), a positive predictive value of 81.5% (95% CI 61.9-93.7%) and a negative predictive value of 76.5% (95% CI 58.8-89.3%). The diagnostic accuracy of 18F-FDG PET was higher in patients not receiving immunosuppressive drugs (93.3 vs 64.5%, p = 0.006). Taken in context with other available diagnostic modalities, the addition of 18F-FDG PET increased the clinical diagnostic accuracy from 54.1 to 70.5% (p = 0.04). The addition of 18F-FDG PET increased the number of indicated biopsies from 22 of 61 patients (36.1%) to 25 of 61 patients (41.0%) and changed the treatment recommendation in 8 of 30 patients (26.7%) not receiving immunosuppressive medication and in 7 of 31 patients (22.6%) receiving immunosuppressive medication. 18F-FDG PET is a sensitive and specific imaging tool for large vessel vasculitis, especially when performed in patients not receiving immunosuppressive drugs. It increases the overall diagnostic accuracy and has an impact on the clinical management in a significant proportion of patients. (orig.)

  13. Perceptual centres in speech - an acoustic analysis

    Science.gov (United States)

    Scott, Sophie Kerttu

    Perceptual centres, or P-centres, represent the perceptual moments of occurrence of acoustic signals - the 'beat' of a sound. P-centres underlie the perception and production of rhythm in perceptually regular speech sequences. P-centres have been modelled both in speech and non speech (music) domains. The three aims of this thesis were toatest out current P-centre models to determine which best accounted for the experimental data bto identify a candidate parameter to map P-centres onto (a local approach) as opposed to the previous global models which rely upon the whole signal to determine the P-centre the final aim was to develop a model of P-centre location which could be applied to speech and non speech signals. The first aim was investigated by a series of experiments in which a) speech from different speakers was investigated to determine whether different models could account for variation between speakers b) whether rendering the amplitude time plot of a speech signal affects the P-centre of the signal c) whether increasing the amplitude at the offset of a speech signal alters P-centres in the production and perception of speech. The second aim was carried out by a) manipulating the rise time of different speech signals to determine whether the P-centre was affected, and whether the type of speech sound ramped affected the P-centre shift b) manipulating the rise time and decay time of a synthetic vowel to determine whether the onset alteration was had more affect on P-centre than the offset manipulation c) and whether the duration of a vowel affected the P-centre, if other attributes (amplitude, spectral contents) were held constant. The third aim - modelling P-centres - was based on these results. The Frequency dependent Amplitude Increase Model of P-centre location (FAIM) was developed using a modelling protocol, the APU GammaTone Filterbank and the speech from different speakers. The P-centres of the stimuli corpus were highly predicted by attributes of

  14. The new AMS control centre

    CERN Multimedia

    Anaïs Schaeffer

    2011-01-01

    Construction work for the future AMS control room began in November 2010 and should be finished this June. The new building, which will have been completed in record time thanks to the professionalism of the project team, will soon be ready to receive the initial data from the AMS experiment.     Luigi Scibile and Michael Poehler, from the GS department, at the AMS control centre construction site.   The Alpha Magnetic Spectrometer (AMS) is due to wing its way towards the International Space Station (ISS) on board the shuttle Discovery in April. Mainly intended for research on antimatter and dark matter, the data collected by AMS will be sent to Houston in the United States and then directly to CERN’s new Building 946. Construction work for the AMS control centre building on the Route Gentner at CERN’s Prévessin site started in November 2010 and must be completed in time to receive the first data from the spectrometer in June. “It normall...

  15. Proton Therapy Verification with PET Imaging

    Science.gov (United States)

    Zhu, Xuping; Fakhri, Georges El

    2013-01-01

    Proton therapy is very sensitive to uncertainties introduced during treatment planning and dose delivery. PET imaging of proton induced positron emitter distributions is the only practical approach for in vivo, in situ verification of proton therapy. This article reviews the current status of proton therapy verification with PET imaging. The different data detecting systems (in-beam, in-room and off-line PET), calculation methods for the prediction of proton induced PET activity distributions, and approaches for data evaluation are discussed. PMID:24312147

  16. PET/MR Imaging in Heart Disease.

    Science.gov (United States)

    Rischpler, Christoph; Nekolla, Stephan G

    2016-10-01

    Hybrid PET/MR imaging is a complex imaging modality that has raised high expectations not only for oncological and neurologic imaging applications, but also for cardiac imaging applications. Initially, physicians and physicists had to become accustomed to technical challenges including attenuation correction, gating, and more complex workflow and more elaborate image analysis as compared with PET/CT or standalone MR imaging. PET/MR imaging seems to be particularly valuable to assess inflammatory myocardial diseases (such as sarcoidosis), to cross-validate PET versus MR imaging data (eg, myocardial perfusion imaging), and to help validate novel biomarkers of various disease states (eg, postinfarction inflammation). PMID:27593250

  17. Advances in time-of-flight PET.

    Science.gov (United States)

    Surti, Suleman; Karp, Joel S

    2016-01-01

    This paper provides a review and an update on time-of-flight PET imaging with a focus on PET instrumentation, ranging from hardware design to software algorithms. We first present a short introduction to PET, followed by a description of TOF PET imaging and its history from the early days. Next, we introduce the current state-of-art in TOF PET technology and briefly summarize the benefits of TOF PET imaging. This is followed by a discussion of the various technological advancements in hardware (scintillators, photo-sensors, electronics) and software (image reconstruction) that have led to the current widespread use of TOF PET technology, and future developments that have the potential for further improvements in the TOF imaging performance. We conclude with a discussion of some new research areas that have opened up in PET imaging as a result of having good system timing resolution, ranging from new algorithms for attenuation correction, through efficient system calibration techniques, to potential for new PET system designs.

  18. The role of PET in thyroid cancer

    Energy Technology Data Exchange (ETDEWEB)

    Seok, Yeo Jeong [College of Medicine, Ulsan Univ., Seoul (Korea, Republic of)

    2002-06-01

    The role of PET in the diagnosis and management of thyroid cancer is discussed. The major role of F-18 FDG PET is in patients with discordant negative I-131 scan and a positive serum thyroglobulin values. F-18 FDG PET scan localized metastatic sites in I-131 scan-negative thyroid carcinoma patients with high accuracy. F-18 PET is also valuable in medullary thyroid cancer with high calcitonin level. Focal thyroid uptake in patients with non-thyroidal disease has high likelihood of thyroid cancer.

  19. Dynamic observation by PET in epilepsy

    International Nuclear Information System (INIS)

    Before the era when positron emission tomography (PET) has emerged, much controversy has existed concerning regional cerebral blood flow in partial epilepsy. In 1979, PET revealed that cerebral blood flow is decreased during the interictal period, but is remarkably increased in the intraictal phase. In this paper, historical process of dynamic observation in epilepsy is reviewed. Potential use and limitations of PET in the clinical setting are discussed in view of the scanning methods and the relationships between PET and electroencephalograms, magnetic resonance imaging, and surgical treatment. (N.K.) 106 refs

  20. PET-Computed Tomography in Veterinary Medicine.

    Science.gov (United States)

    Randall, Elissa K

    2016-05-01

    PET/CT is an advanced imaging modality that is becoming more commonly used in veterinary medicine. It is most commonly used to image patients with cancer, and the most frequently used radiopharmaceutical is F-18 FDG. F-18 FDG is a glucose analog that highlights areas of increased glucose metabolism on the PET images. CT images provide excellent anatomic depiction and aid in interpretation of the PET data. Many types of cancer are hypermetabolic on PET/CT scans, but normal structures and areas of inflammation are also hypermetabolic, so knowledge of normal imaging and cytologic or histopathologic evaluation of lesions is essential.

  1. MIKE's PET: A participant-based experiment tracking tool for HCI practitioners using mobile devices

    Science.gov (United States)

    Mohamedally, Dean; Edlich, Stefan; Klaus, Enrico; Zaphiris, Panayiotis

    2006-02-01

    Knowledge Elicitation (KE) methods are an integral part of Human Computer Interaction (HCI) practices. They are a key aspect to the synthesis of psychology empirical methods with requirements engineering, User Centred Design (UCD) and user evaluations. Examples of these methods include prototyping, focus groups, interviews, surveys and direct video observation. The MIKE project (Mobile Interactive Knowledge Elicitation) at the Centre for HCI Design, City University London, UK provides mobile cyberscience capabilities for HCI practitioners conducting such research while at stakeholder locations. This paper reports on the design and development of a new MIKE based tool, named PET, a Participant-based Experiment Tracking tool for HCI practitioners using Java-based (J2ME) mobile devices. PET integrates its user tracking techniques with the development of the second generation implementation of the CONKER (COllaborative Non-linear Knowledge Elicitation Repository) Web Service. We thus report further on CONKER v2.0's new capabilities developed to enable tighter collaboration and empirical data management between HCI practitioners, considering their UCD needs. The visualisation, tracking and recording of HCI participant-based datasets via PET is explored with close connectivity with the CONKER v2.0 Web Service, in order to provide mobile-web cyberscience for remote and local HCI practitioners.

  2. {sup 18}F-FDG PET and PET/CT in Burkitt's lymphoma

    Energy Technology Data Exchange (ETDEWEB)

    Karantanis, Dimitrios, E-mail: dkarantanis@nuclmed.ne [Division of Nuclear Medicine, Department of Radiology, Mayo Clinic, Rochester, MN (United States); Durski, Jolanta M.; Lowe, Val J.; Nathan, Mark A.; Mullan, Brian P. [Division of Nuclear Medicine, Department of Radiology, Mayo Clinic, Rochester, MN (United States); Georgiou, Evangelos [Medical Physics Department, Medical School, University of Athens (Greece); Johnston, Patrick B. [Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN (United States); Wiseman, Gregory A. [Division of Nuclear Medicine, Department of Radiology, Mayo Clinic, Rochester, MN (United States)

    2010-07-15

    Objective: To explore the value of {sup 18}F fluorodeoxy-glucose (FDG) positron emission tomography (PET) in Burkitt's lymphoma. Methods: All Burkitt's lymphoma patients referred for FDG PET or FDG PET/computed tomography (CT) exams at our institution from June 2003 to June 2006 were included. Selected patients were followed and clinical information was reviewed retrospectively. Results from FDG PET-PET/CT, as blindly reviewed by a consensus of two experienced readers, were compared with the status of the disease as determined by other laboratory, clinical and imaging exams and clinical follow-up. FDG PET-PET/CT results were classified as true positive or negative and false positive or negative. The degree of FDG uptake in the positive lesions was semiquantified as maximum standard uptake value (SUVmax). Results: Fifty-seven FDG PET-PET/CT exams were done in 15 patients. Seven exams were done for initial staging, 8 during and 14 after the completion of therapy, and 28 for disease surveillance. For nodal disease FDG PET-PET/CT was true positive in 8, true negative in 47 and false positive in 2 exams (sensitivity 100%, specificity 96%). For extranodal disease FDG PET-PET/CT was true positive in 6, true negative in 48 and false positive in 3 exams (sensitivity 100%, specificity 94%). The mean SUVmax for the positive nodal lesions was 15.7 (range 6.9-21.7, median 18.5) and for extranodal lesions was 14.2 (range 6.2-24.3, median 12.4). Conclusions: FDG PET-PET/CT is sensitive for the detection of viable disease in Burkitt's lymphoma. Affected areas demonstrated high degree of uptake that was reversible upon successful implementation of treatment.

  3. Centre for nuclear engineering University of Toronto annual report 1984

    International Nuclear Information System (INIS)

    The annual report of the Centre for Nuclear Engineering, University of Toronto covers the following subjects: message from the Dean; Chairman's message; origins of the centre; formation of the centre; new nuclear appointments; and activities of the centre, 1984

  4. A proposal of an open PET geometry

    Energy Technology Data Exchange (ETDEWEB)

    Yamaya, Taiga [Molecular Imaging Center, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba, 263-8555 (Japan); Inaniwa, Taku [Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555 (Japan); Minohara, Shinichi [Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555 (Japan); Yoshida, Eiji [Molecular Imaging Center, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba, 263-8555 (Japan); Inadama, Naoko [Molecular Imaging Center, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba, 263-8555 (Japan); Nishikido, Fumihiko [Molecular Imaging Center, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba, 263-8555 (Japan); Shibuya, Kengo [Molecular Imaging Center, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba, 263-8555 (Japan); Lam, Chih Fung [Molecular Imaging Center, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba, 263-8555 (Japan); Murayama, Hideo [Molecular Imaging Center, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba, 263-8555 (Japan)

    2008-02-07

    The long patient port of a PET scanner tends to put stress on patients, especially patients with claustrophobia. It also prevents doctors and technicians from taking care of patients during scanning. In this paper, we proposed an 'open PET' geometry, which consists of two axially separated detector rings. A long and continuous field-of-view (FOV) including a 360 deg. opened gap between two detector rings can be imaged enabling a fully 3D image reconstruction of all the possible lines-of-response. The open PET will become practical if iterative image reconstruction methods are applied even though image reconstruction of the open PET is analytically an incomplete problem. First we implemented a 'masked' 3D ordered subset expectation maximization (OS-EM) in which the system matrix was obtained from a long 'gapless' scanner by applying a mask to detectors corresponding to the open space. Next, in order to evaluate imaging performance of the proposed open PET geometry, we simulated a dual HR+ scanner (ring diameter of D = 827 mm, axial length of W = 154 mm x 2) separated by a variable gap. The gap W was the maximum limit to have axially continuous FOV of 3W though the maximum diameter of FOV at the central slice was limited to D/2. Artifacts, observed on both sides of the open space when the gap exceeded W, were effectively reduced by inserting detectors partially into unnecessary open spaces. We also tested the open PET geometry using experimental data obtained by the jPET-D4. The jPET-D4 is a prototype brain scanner, which has 5 rings of 24 detector blocks. We simulated the open jPET-D4 with a gap of 66 mm by eliminating 1 block-ring from experimental data. Although some artifacts were seen at both ends of the opened gap, very similar images were obtained with and without the gap. The proposed open PET geometry is expected to lead to realization of in-beam PET, which is a method for an in situ monitoring of charged particle therapy, by

  5. PET/CT without capacity limitations: a Danish experience from a European perspective

    DEFF Research Database (Denmark)

    Høilund-Carlsen, Poul Flemming; Gerke, Oke; Vilstrup, Mie Holm;

    2011-01-01

    OBJECTIVES: We report the 3-year clinical experience of a large new Danish PET/CT centre without capacity limitations in relation to national and European developments. METHODS: The use of PET/CT in cancer was registered from early 2006 to early 2009 to judge the impact on patient management...... and to compare it with national and European trends. RESULTS: 6056 PET/CT examinations were performed in 4327 patients. Activity increased by 86 examinations per month compared with the same month the year before. Referrals came primarily from oncology (23.0%), haematology (21.6%), surgery (12.6%), internal...... medicine (12.7%) and gynaecology (5.5%). Referral indications were diagnosis (31.3%), staging (22.3%), recurrence detection (21.2%), response evaluation (17.0%) and other (8.2%). Response from nearly 60% of users showed that PET/CT caused a change in diagnosis and/or staging and/or treatment plan in 36...

  6. Multimodal imaging utilising integrated MR-PET for human brain tumour assessment

    Energy Technology Data Exchange (ETDEWEB)

    Neuner, Irene [Institute of Neuroscience and Medicine 4, INM 4, Juelich (Germany); RWTH Aachen University, Department of Psychiatry, Psychotherapy and Psychosomatics, Aachen (Germany); JARA-BRAIN-Translational Medicine, Aachen (Germany); Kaffanke, Joachim B. [Institute of Neuroscience and Medicine 4, INM 4, Juelich (Germany); MR-Transfer e.K., Wuppertal (Germany); Langen, Karl-Josef; Kops, Elena Rota; Tellmann, Lutz; Stoffels, Gabriele; Weirich, Christoph; Filss, Christian; Scheins, Juergen; Herzog, Hans [Institute of Neuroscience and Medicine 4, INM 4, Juelich (Germany); Shah, N. Jon [Institute of Neuroscience and Medicine 4, INM 4, Juelich (Germany); RWTH Aachen University, Department of Neurology, Aachen (Germany); JARA-BRAIN-Translational Medicine, Aachen (Germany)

    2012-12-15

    The development of integrated magnetic resonance (MR)-positron emission tomography (PET) hybrid imaging opens up new horizons for imaging in neuro-oncology. In cerebral gliomas the definition of tumour extent may be difficult to ascertain using standard MR imaging (MRI) only. The differentiation of post-therapeutic scar tissue, tumour rests and tumour recurrence is challenging. The relationship to structures such as the pyramidal tract to the tumour mass influences the therapeutic neurosurgical approach. The diagnostic information may be enriched by sophisticated MR techniques such as diffusion tensor imaging (DTI), multiple-volume proton MR spectroscopic imaging (MRSI) and functional MRI (fMRI). Metabolic imaging with PET, especially using amino acid tracers such as {sup 18}F-fluoroethyl-l-tyrosine (FET) or {sup 11}C-l-methionine (MET) will indicate tumour extent and response to treatment. The new technologies comprising MR-PET hybrid systems have the advantage of providing comprehensive answers by a one-stop-job of 40-50 min. The combined approach provides data of different modalities using the same iso-centre, resulting in optimal spatial and temporal realignment. All images are acquired exactly under the same physiological conditions. We describe the imaging protocol in detail and provide patient examples for the different imaging modalities such as FET-PET, standard structural imaging (T1-weighted, T2-weighted, T1-weighted contrast agent enhanced), DTI, MRSI and fMRI. (orig.)

  7. Multimodal imaging utilising integrated MR-PET for human brain tumour assessment

    International Nuclear Information System (INIS)

    The development of integrated magnetic resonance (MR)-positron emission tomography (PET) hybrid imaging opens up new horizons for imaging in neuro-oncology. In cerebral gliomas the definition of tumour extent may be difficult to ascertain using standard MR imaging (MRI) only. The differentiation of post-therapeutic scar tissue, tumour rests and tumour recurrence is challenging. The relationship to structures such as the pyramidal tract to the tumour mass influences the therapeutic neurosurgical approach. The diagnostic information may be enriched by sophisticated MR techniques such as diffusion tensor imaging (DTI), multiple-volume proton MR spectroscopic imaging (MRSI) and functional MRI (fMRI). Metabolic imaging with PET, especially using amino acid tracers such as 18F-fluoroethyl-l-tyrosine (FET) or 11C-l-methionine (MET) will indicate tumour extent and response to treatment. The new technologies comprising MR-PET hybrid systems have the advantage of providing comprehensive answers by a one-stop-job of 40-50 min. The combined approach provides data of different modalities using the same iso-centre, resulting in optimal spatial and temporal realignment. All images are acquired exactly under the same physiological conditions. We describe the imaging protocol in detail and provide patient examples for the different imaging modalities such as FET-PET, standard structural imaging (T1-weighted, T2-weighted, T1-weighted contrast agent enhanced), DTI, MRSI and fMRI. (orig.)

  8. Clinical evaluation of PET image reconstruction using a spatial resolution model

    DEFF Research Database (Denmark)

    Andersen, Flemming Littrup; Klausen, Thomas Levin; Loft, Annika;

    2013-01-01

    . The relative change in PET quantification (SUV(max), SUV(mean), volume) of lesions seen on R1 and R2 is reported as (R2-R1)/R1. Furthermore, SUV(max) and SUV(mean) was measured for a 3cm spherical norm region in the right lobe of the healthy liver for R1 and R2. RESULTS: Clinical reading revealed 91 and 103...... positive lesions for R1 and R2, respectively. For all lesions SUV(max) (R2) was higher than SUV(max) (R1). Regression analysis indicated that the relative increase in SUV(max) (and SUV(mean)) decreased with lesion size, whilst it increased with increasing radial distance from the centre of the field...... of view (FOV). There was no significant difference in SUV(mean) in homogenous liver tissue between R1 and R2. CONCLUSION: In whole-body FDG-PET/CT using routine clinical protocols, PSF-based PET reconstruction increases lesion detection and affects SUV(max) measurements compared to standard AW-OSEM PET...

  9. Positron emission tomography (PET) in psychiatry. PET in der Psychiatrie

    Energy Technology Data Exchange (ETDEWEB)

    Herholz, K. (Max-Planck-Institut fuer Neurologische Forschung und Neurologische Klinik der Universitaet Koeln (Germany))

    1993-08-13

    Currently, clinical PET is mainly useful in psychiatry and related areas for differential diagnosis of dementia. In dementia of Alzheimer type reductions of glucose metabolism are found mainly in the temporoparietal assocaiton cortex, in Pick's disease mainly in the frontal cortex, and in Huntington's disease in the striatum. Other demential diseases usually show less toposelective metabolic impairment. In the future, new diagnostic possibilities may arise from analysis of functional stimulation of specific brain areas and from the use of ligands for specific neurotransmitter systems. (orig.)

  10. Powering the Future Data Centre

    DEFF Research Database (Denmark)

    Zhang, Zhe

    2010-01-01

    The extended run Uninterruptible Power Supply system (UPSs) which powered by fuel cells and supercapcitors, is a promising solution for future data centre to obtain environmentfriendly energy efficient and cost effective. There are many challenges in power electronic interface circuits, because......: • Optimized design method for dual active bridge (DAB) converter and its derived circuits; • A novel hybrid dc-dc converter and its corresponding optimal design method are proposed; • An improved dual input current-fed DC-DC converter with bidirectional power conversion ability is investigated; • Extend...... the circuit level decoupling modulation scheme into 3LNPC inverter. As to the DAB converter, through the power factor and harmonics analysis, the dominated loss factor is found in variable input voltage range. Optimized parameter choosing method is used to decide the ac inductance and switching frequency...

  11. Role of FDG-PET and PET/CT in the diagnosis of prolonged febrile states

    Energy Technology Data Exchange (ETDEWEB)

    Jaruskova, M.; Belohlavek, O. [Na Homolce Hospital, PET Center, Prague 5 (Czech Republic)

    2006-08-15

    The role of FDG-PET and PET/CT in patients whose main symptom is prolonged fever has not yet been defined. We addressed this topic in a retrospective study. A total of 124 patients (referred between May 2001 and December 2004) with fever of unknown origin or prolonged fever due to a suspected infection of a joint or vascular prosthesis were included in the study. The patients underwent either FDG-PET or FDG-PET/CT scanning. Sixty-seven patients had a negative focal FDG-PET finding; in this group the method was regarded as unhelpful in determining a diagnosis, and no further investigation was pursued. We tried to obtain clinical confirmation for all patients with positive PET findings. Fifty-seven (46%) patients had positive FDG-PET findings. In six of them no further clinical information was available. Fifty-one patients with positive PET findings and 118 patients in total were subsequently evaluated. Systemic connective tissue disease was confirmed in 17 patients, lymphoma in three patients, inflammatory bowel disease in two patients, vascular prosthesis infection in seven patients, infection of a hip or knee replacement in seven patients, mycotic aneurysm in two patients, abscess in four patients and AIDS in one patient. In eight (16%) patients the finding was falsely positive. FDG-PET or PET/CT contributed to establishing a final diagnosis in 84% of the 51 patients with positive PET findings and in 36% of all 118 evaluated patients with prolonged fever. (orig.)

  12. PET and PET/CT imaging for the earliest detection and treatment of colorectal carcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Carter, Kevin [Michigan State Univ., Pontiac, MI (United States). POH Medical Center; Kotlyarov, Eduard [Michigan State Univ., Pontiac, MI (United States). POH Medical Center; Georgetown Univ. (United States)

    2005-10-15

    Approximately 150,000 new cases of colorectal cancer are diagnosed each year with the life time risk of developing colon caner in developed nations being 4.6% in men and 3.2% in women. Screening patients is essential early detection of colon carcinoma to aid in complete resection. Unfortunately current screening methods carry with them poor patient compliance. PET and PET/CT may be a significant part of this screening solution. The authors reviewed and analyzed the English language articles and case reports identified on Medline during the last 10 years. PET and PET/CT results for colorectal carcinoma were tabulated and presented for the fifth Scientific Meeting of the Brazilian Society of Nuclear Biosciences. Though most studies have been retrospective analysis in using PET for staging for other malignant processes the cases that have identified additional uptake in the colon are important. The accuracy when utilizing PET and PET/CT in this screening method has a sensitivity between 65 and 90% with a specificity of 84 to 90% and a positive predictive value 71 to 78%. Early stages of malignancies and pre-cancerous polyps avidly accumulates F-18 Deoxyfluoro glucose allowing us to conclude that whole body PET and PET/CT is an essential component in the work up, staging or treatment monitoring in colon carcinoma. We have to continue to accumulate data for possible introduction for whole body PET and PET/CT scanning for colon carcinoma and precancerous polyps.(author)

  13. Inventarisatie van ontwikkelingen van PET-CT

    NARCIS (Netherlands)

    Bijwaard H; LSO; mev

    2011-01-01

    De Nederlandse ziekenhuispraktijk heeft de relatief nieuwe PET-CT-technologie omarmd: het aantal PET-CT-scanners en hun toepassingen nemen snel toe. De toepassingen in de medische praktijk lopen voor op de richtlijnen uit 2007. Voor deze richtlijnen wordt daarom een frequentere update aanbevolen. Vo

  14. Quantitative Techniques in PET-CT Imaging

    NARCIS (Netherlands)

    Basu, Sandip; Zaidi, Habib; Holm, Soren; Alavi, Abass

    2011-01-01

    The appearance of hybrid PET/CT scanners has made quantitative whole body scanning of radioactive tracers feasible. This paper deals with the novel concepts for assessing global organ function and disease activity based on combined functional (PET) and structural (CT or MR) imaging techniques, their

  15. Integrating Pet Therapy into Daily School Life

    Science.gov (United States)

    Brous, Miriam T.

    2010-01-01

    Stories abound in literature of the ways that people and their pets have fostered and created valuable relationships. More recently, research has shown a strong impact from the pet relationship in health-related settings. Positive changes have been seen in people developing resilience, self-reliance, and in making progress in treatment. Children…

  16. Smart work centres in rural areas

    DEFF Research Database (Denmark)

    Lorentzen, Anne Birte

    This paper discusses the establishment of telework centres as an element in local development strategies in rural areas, with a particular view to two new telework centres in region North Denmark. The paper argues that telework centres do not represent an easy solution to problems of local...... development and environmental sustainability, and further, that technology may not even be the most important feature needed to make them function as such....

  17. Activities of Radiation Protection Centre in 2000

    CERN Document Server

    Radiat. Prot. Cent. Vilnius

    2001-01-01

    Description of the activities of Radiation Protection Centre in 2000 is presented. Radiation Protection Centre is responsible for radiation protection issues. Currently there are six departments at Radiation Protection Centre: two in Vilnius - Department of Radiation Protection Supervision and Control and Department of Programs and Expertise, and four in the districts. Brief information on subject controlled by each departments is provided focusing on main achievements and events.

  18. Elm Farm Organic Research Centre December 2006

    OpenAIRE

    Sanders, Richard; Whiltley, Andrew; Haigh, Zoe; Clarke, Sarah; Hitchings, Roger; O'Brien, Josie

    2006-01-01

    The Organic Research Centre. Elm Farm Research Centre Bulletin with Technical Updates from The Organic Advisory Service is a regular publication from The Organic Research Centre. The current issue covers: Report from 2006 Cirencester Conference; Quest for more home produced organic food; in a world where bread matters; Improving wheat with plenty of parents; Unlocking the secrets of the ancient (cereal varieties); Brain food- a good read; Not to late to protect the future: The organic...

  19. Business plan – Tennis centre modernization

    OpenAIRE

    Moravec, Martin

    2012-01-01

    The goal of this master's thesis "Business plan -- Tennis centre modernization" - is creating and writing the business plan for the reconstruction of the existing tennis centre. The theoretical part describes characteristics of small and medium sized enterprises, their meaning. Describes the necessary parts of the business plan, its possible structure. The paper involves the knowledge gained into the concrete case of the tennis centre. Describes its nowadays conditions and possible solutions....

  20. Application of PET and PET/CT imaging for cancer screening

    International Nuclear Information System (INIS)

    The aim of this study was to evaluate the potential application of 18F-fluorodeoxyglucose (FDG) Positron Emission Tomography (PET) and PET/CT for cancer screening in asymptomatic individuals. Methods: The subjects consisted of 3631 physical check up examinees (1947 men, 1684 women; mean age ±SD, 52.1±8.2 y) with non-specific medical histories. Whole-body FDG PET (or PET/CT), ultrasound and tumor markers were performed on all patients. Focal hypermetabolic areas with intensities equal to or exceeding the level of FDG uptake in the brain and bladder were considered abnormal and interpreted as neoplasia. Follow-up periods were longer than one year. Results: Among the 3631 FDG PET (including 1687 PET/CT), ultrasound and tumor markers examinations, malignant tumors were discovered in 47 examinees (1.29%). PET findings were true-positive in 38 of the 47 cancers (80.9%). In addition, 32 of the 47 cancers were performed with the PET-CT scan. PET detected cancer lesions in 28 of the 32 examinees. However, the CT detected cancer lesions in only 15 of 32 examinees. Conclusion: The sensitivity of FDG PET in the detection of a wide variety of cancers is high. Most cancer can be detected with FDG PET in a resectable stage. CT of the PET/CT for localization and characteristics of the lesion shows an increased specificity of the PET scan. Using ultrasound and tumor markers may complement the PET scan in cancer screening for hepatic and urologic neoplasms. (authors)

  1. Choline-PET/CT for imaging prostate cancer; Cholin-PET/CT zur Bildgebung des Prostatakarzinoms

    Energy Technology Data Exchange (ETDEWEB)

    Krause, Bernd Joachim [Klinik- und Poliklinik fuer Nuklearmedizin, Klinikum rechts der Isar, Technische Univ. Muenchen (Germany); Treiber, U.; Schwarzenboeck, S.; Souvatzoglou, M. [Klinik fuer Urologie, Klinikum rechts der Isar, Technische Univ. Muenchen (Germany)

    2010-09-15

    PET and PET/CT using [{sup 11}C]- and [{sup 18}F]-labelled choline derivatives are increasingly being used for imaging of prostate cancer. The value of PET and PET/CT with [{sup 11}C]- and [{sup 18}F]-labelled choline derivates in biochemical recurrence of prostate cancer has been examined in many studies and demonstrates an increasing importance. Primary prostate cancer can be detected with moderate sensitivity using PET and PET/CT using [{sup 11}C]- and [{sup 18}F]-labelled choline derivatives - the differentiation between benign prostatic hyperplasia, prostatitis or high-grade intraepithelial neoplasia (HGPIN) is not always possible. At the present time [{sup 11}C]choline PET/CT is not recommended in the primary setting but may be utilized in clinically suspected prostate cancer with repeatedly negative prostate biopsies, in preparation of a focused re-biopsy. Promising results have been obtained for the use of PET and PET/CT with [{sup 11}C]- and [{sup 18}F]-labelled choline derivates in patients with biochemical recurrence. The detection rate of choline PET and PET/CT for local, regional, and distant recurrence in patients with a biochemical recurrence shows a linear correlation with PSA values at the time of imaging and reaches about 75% in patients with PSA > 3 ng/mL. At PSA values below 1 ng/mL, the recurrence can be diagnosed with choline PET/CT in approximately 1/3 of the patients. PET and PET/CT with [{sup 11}C]- and [{sup 18}F]choline derivates can be helpful for choosing a therapeutic strategy in the sense of an individualized treatment: since an early diagnosis of recurrence is crucial to the choice of optimal treatment. The localization of the site of recurrence - local recurrence, lymph node metastasis or systemic dissemination - has important influence on the therapy regimen. (orig.)

  2. Childhood diarrhoea in Danish day care centres could be associated with infant colic, low birthweight and antibiotics

    DEFF Research Database (Denmark)

    Jensen, Betina Hebbelstrup; Röser, Dennis; Andreassen, Bente Utoft;

    2016-01-01

    AIM: Diarrhoea is very common in children attending day care centres. The aim of this study was to examine certain predisposing risk factors for an association with diarrhoea, including foreign travel, treatment with antibiotics, having household pets, infant colic, bottle feeding, using a pacifier...... and low birth weight. METHODS: A dynamic one-year follow-up cohort study comprising 179 children from 36 day care centres was conducted from September 2009 to July 2013 in Copenhagen, Denmark. Questionnaires were sent to the children's parents or legal guardians every two months for a year, requesting...... the risk of diarrhoea in Danish children in day care centres This article is protected by copyright. All rights reserved....

  3. Marketingová strategie firmy Austin Detonator, s.r.o. na zahraničních trzích

    OpenAIRE

    Vlčková, Veronika

    2012-01-01

    This thesis deals with the marketing strategy of the firm Austin Detonator s.r.o., which is today the largest European manufacturer of electric, non-electric and electronic detonators for use in quarries, mines during mining and the construction of transport infrastructure, including tunnels. In addition to the analysis of the marketing strategy next part maps markets which the company operates, determines the largest competitors and figures out what tools of marketing mix company uses to com...

  4. Can pets function as family members?

    Science.gov (United States)

    Cohen, Susan Phillips

    2002-10-01

    This exploratory study investigated how clients of a large urban veterinary center viewed the role of their pet in the famil and how they compared this role to that of humans. In Phase 1, randomly selected clients (N = 201) completed a questionnaire containing scales delineating family relationships and pet attachment. Being either a man or a college graduate was associated with lesser feelings of psychological kinship and intimacy, both with pets and people. Neither living with a partner norhaving a child affected the strength of pet relationships. In Phase 2, 16 participants from Phase I completed a social network instrument and answered questions about family roles and boundaries. Thirteen of the 16 respondents said that there were circumstances in which they would give a scarce drug to their pet in preference to a person outside the family. PMID:12365764

  5. Co-registration between locally acquired CT and PET from a remote location

    International Nuclear Information System (INIS)

    Aim: The process of referring patients abroad for PET scan was developed in steps, and the corresponding aims were: 1) To provide enough clinical information to the PET centre for correct interpretation of the examination. 2) To transfer the PET data. 3) To optimize the CT data for co-registration. 4) To achieve a good topographical co-registration. 5) To correlate the lesions and interpret eventual discrepancies. 6) To issue a common report . Method: 1) The patients were referred to the Dept NM Saarland University Medical Center with their CT scan and a form specifying the presumptive diagnosis, a short history and the type of and delay since treatment. 2) The data were transferred by Internet to the Dept NM of CHLuxemburg; the original PET report and local PET images were loaded on their respective servers 3) The spiral CT (Dept Radiology CHL) scan was recorded over the whole trunk, supine, arms along the body, at tidal breathing or at end-expiration (diaphragm), without medication or contrast, at low mA, on a conventional palet. 4) The CT and PET data were automatically corrected for slice thickness and number; co-registration was done manually, initially starting with a recognizable transaxial slice and then progressing up and down on compressed CT data, later on interactively along 3 axes on full size CT data; co-registration was fine tuned at various levels of the trunk (Hermes). 5) The co-registered images were reviewed jointly lesion by lesion by specialists in Radiology and Nuclear Medicine; eventual discrepancies were interpreted taking into account the clinical history and the specificities of each modality. 6) A 'Correlative Imaging' report was issued. Results of 15+ co-registered lung carcinomas and 12+ lymphomas are presented. Conclusion: Correlative imaging not only improves on the localisation of PET lesions, but also on a better discrimination between malignant and benign lesions as seen either on CT or PET. Clearly the availability of other

  6. Neighborhood Landscape Spatial Patterns and Land Surface Temperature: An Empirical Study on Single-Family Residential Areas in Austin, Texas.

    Science.gov (United States)

    Kim, Jun-Hyun; Gu, Donghwan; Sohn, Wonmin; Kil, Sung-Ho; Kim, Hwanyong; Lee, Dong-Kun

    2016-09-02

    Rapid urbanization has accelerated land use and land cover changes, and generated the urban heat island effect (UHI). Previous studies have reported positive effects of neighborhood landscapes on mitigating urban surface temperatures. However, the influence of neighborhood landscape spatial patterns on enhancing cooling effects has not yet been fully investigated. The main objective of this study was to assess the relationships between neighborhood landscape spatial patterns and land surface temperatures (LST) by using multi-regression models considering spatial autocorrelation issues. To measure the influence of neighborhood landscape spatial patterns on LST, this study analyzed neighborhood environments of 15,862 single-family houses in Austin, Texas, USA. Using aerial photos, geographic information systems (GIS), and remote sensing, FRAGSTATS was employed to calculate values of several landscape indices used to measure neighborhood landscape spatial patterns. After controlling for the spatial autocorrelation effect, results showed that larger and better-connected landscape spatial patterns were positively correlated with lower LST values in neighborhoods, while more fragmented and isolated neighborhood landscape patterns were negatively related to the reduction of LST.

  7. Neighborhood Landscape Spatial Patterns and Land Surface Temperature: An Empirical Study on Single-Family Residential Areas in Austin, Texas

    Directory of Open Access Journals (Sweden)

    Jun-Hyun Kim

    2016-09-01

    Full Text Available Rapid urbanization has accelerated land use and land cover changes, and generated the urban heat island effect (UHI. Previous studies have reported positive effects of neighborhood landscapes on mitigating urban surface temperatures. However, the influence of neighborhood landscape spatial patterns on enhancing cooling effects has not yet been fully investigated. The main objective of this study was to assess the relationships between neighborhood landscape spatial patterns and land surface temperatures (LST by using multi-regression models considering spatial autocorrelation issues. To measure the influence of neighborhood landscape spatial patterns on LST, this study analyzed neighborhood environments of 15,862 single-family houses in Austin, Texas, USA. Using aerial photos, geographic information systems (GIS, and remote sensing, FRAGSTATS was employed to calculate values of several landscape indices used to measure neighborhood landscape spatial patterns. After controlling for the spatial autocorrelation effect, results showed that larger and better-connected landscape spatial patterns were positively correlated with lower LST values in neighborhoods, while more fragmented and isolated neighborhood landscape patterns were negatively related to the reduction of LST.

  8. Neighborhood Landscape Spatial Patterns and Land Surface Temperature: An Empirical Study on Single-Family Residential Areas in Austin, Texas.

    Science.gov (United States)

    Kim, Jun-Hyun; Gu, Donghwan; Sohn, Wonmin; Kil, Sung-Ho; Kim, Hwanyong; Lee, Dong-Kun

    2016-01-01

    Rapid urbanization has accelerated land use and land cover changes, and generated the urban heat island effect (UHI). Previous studies have reported positive effects of neighborhood landscapes on mitigating urban surface temperatures. However, the influence of neighborhood landscape spatial patterns on enhancing cooling effects has not yet been fully investigated. The main objective of this study was to assess the relationships between neighborhood landscape spatial patterns and land surface temperatures (LST) by using multi-regression models considering spatial autocorrelation issues. To measure the influence of neighborhood landscape spatial patterns on LST, this study analyzed neighborhood environments of 15,862 single-family houses in Austin, Texas, USA. Using aerial photos, geographic information systems (GIS), and remote sensing, FRAGSTATS was employed to calculate values of several landscape indices used to measure neighborhood landscape spatial patterns. After controlling for the spatial autocorrelation effect, results showed that larger and better-connected landscape spatial patterns were positively correlated with lower LST values in neighborhoods, while more fragmented and isolated neighborhood landscape patterns were negatively related to the reduction of LST. PMID:27598186

  9. Neighborhood Landscape Spatial Patterns and Land Surface Temperature: An Empirical Study on Single-Family Residential Areas in Austin, Texas

    Science.gov (United States)

    Kim, Jun-Hyun; Gu, Donghwan; Sohn, Wonmin; Kil, Sung-Ho; Kim, Hwanyong; Lee, Dong-Kun

    2016-01-01

    Rapid urbanization has accelerated land use and land cover changes, and generated the urban heat island effect (UHI). Previous studies have reported positive effects of neighborhood landscapes on mitigating urban surface temperatures. However, the influence of neighborhood landscape spatial patterns on enhancing cooling effects has not yet been fully investigated. The main objective of this study was to assess the relationships between neighborhood landscape spatial patterns and land surface temperatures (LST) by using multi-regression models considering spatial autocorrelation issues. To measure the influence of neighborhood landscape spatial patterns on LST, this study analyzed neighborhood environments of 15,862 single-family houses in Austin, Texas, USA. Using aerial photos, geographic information systems (GIS), and remote sensing, FRAGSTATS was employed to calculate values of several landscape indices used to measure neighborhood landscape spatial patterns. After controlling for the spatial autocorrelation effect, results showed that larger and better-connected landscape spatial patterns were positively correlated with lower LST values in neighborhoods, while more fragmented and isolated neighborhood landscape patterns were negatively related to the reduction of LST. PMID:27598186

  10. Clinical Applications of FDG PET and PET/CT in Head and Neck Cancer

    Directory of Open Access Journals (Sweden)

    Akram Al-Ibraheem

    2009-01-01

    Full Text Available 18F-FDG PET plays an increasing role in diagnosis and management planning of head and neck cancer. Hybrid PET/CT has promoted the field of molecular imaging in head and neck cancer. This modality is particular relevant in the head and neck region, given the complex anatomy and variable physiologic FDG uptake patterns. The vast majority of 18F-FDG PET and PET/CT applications in head and neck cancer related to head and neck squamous cell carcinoma. Clinical applications of 18F-FDG PET and PET/CT in head and neck cancer include diagnosis of distant metastases, identification of synchronous 2nd primaries, detection of carcinoma of unknown primary and detection of residual or recurrent disease. Emerging applications are precise delineation of the tumor volume for radiation treatment planning, monitoring treatment, and providing prognostic information. The clinical role of 18F-FDG PET/CT in N0 disease is limited which is in line with findings of other imaging modalities. MRI is usually used for T staging with an intense discussion concerning the preferable imaging modality for regional lymph node staging as PET/CT, MRI, and multi-slice spiral CT are all improving rapidly. Is this review, we summarize recent literature on 18F-FDG PET and PET/CT imaging of head and neck cancer.

  11. Nicotinic receptor imaging with F-18 A85380 PET in Alzheimer's disease and normal ageing

    International Nuclear Information System (INIS)

    high affinity but low potency for the nicotinic receptor (i.e. it is a weak agonist). It is selective for the alpha2beta4 (A2B4) subtype. A85380 does not bind to the alpha 7 subtype receptor nor the ganglionic alpha3beta4 subtype and therefore has minimal cardiovascular effects. It also has low affinity for muscle nicotinic receptors (Sullivan JP 1996). These properties indicate a high level of safety when this compound is used in the extremely low (nanomolar) concentrations required for PET imaging studies. Labelling of A85380 with fluorine-18, a positron emitting radioisotope, has been achieved without alteration of the receptor binding characteristics by Frederic Dolle and colleagues at the CEA PET Centre, Orsay (Dolle F et al., 1998). In March 2000, F-18 A85380 PET studies in baboons were presented by Prof. Bernard Maziere at the France Australia Scientific Meeting in Melbourne. After this presentation a collaboration between the CEA PET Centre and ARMC was discussed between Prof. Maziere and Dr. Rowe (Director, Department of Nuclear Medicine and Centre for PET, ARMC). Subsequently in June 2000 at the US SNM meeting in St. Louis further discussions were held between Dr. Rowe and Professor Syrota. In September 2000, draft protocols were exchanged and communication between Frederic Dolle and Henri Tochon-Danguy commenced regarding the radiochemistry. In May 2001, Dr. Rowe visited the CEA PET Centre, Orsay and a collaborative agreement was signed. Subsequently between May and August 2001, CEA PET Centre supplied the chemical precursor, labelling method, toxicology results and human radiation dosimetry data to ARMC. The research plan is to investigate the uptake and distribution of F-18 A85380 with PET in normal elderly persons, and subjects with mild Alzheimer's disease, and to quantify the effect of age on uptake. We will assess the utility of nicotinic receptor imaging with PET for the early diagnosis of AD and its potential for monitoring therapies designed to

  12. The European NEO Coordination Centre

    Science.gov (United States)

    Perozzi, E.; Borgia, B.; Micheli, M.

    An operational approach to NEO (Near-Earth Object) hazard monitoring has been developed at European level within the framework of the Space Situational Awareness Program (SSA) of the European Space Agency (ESA). Through federating European assets and profiting of the expertise developed in European Universities and Research Centers, it has been possible to start the deployment of the so-called SSA NEO Segment. This initiative aims to provide a significant contribution to the worldwide effort to the discovery, follow-up and characterization of the near-Earth object population. A major achievement has been the inauguration in May 2013 of the ESA NEO Coordination Centre located at ESRIN (Frascati, Italy). The goal of the NEOCC Precursor Service operations is twofold: to make available updated information on the NEO population and the associated hazard and to contribute to optimize the NEO observational efforts. This is done by maintaining and improving a Web Portal publicly available at http://neo.ssa.esa.int and by performing follow-up observations through a network of collaborating telescopes and facilities. An overview of the SSA-NEO System and a summary of the first two years of NEOCC operations is presented.

  13. Laparoscopic adrenalectomy: Single centre experience.

    LENUS (Irish Health Repository)

    O'Farrell, N J

    2012-02-01

    BACKGROUND: Laparoscopic adrenalectomy is an attractive alternative to the traditional open approach in the surgical excision of an adrenal gland. It has replaced open adrenalectomy in our institution and we review our experience to date. METHODS: All cases of laparoscopic adrenalectomies in our hospital over eight years (from 2001 to May 2009) were retrospectively reviewed. Patient demographics, diagnosis, length of hospital stay, histology and all operative and post-operative details were evaluated. RESULTS: Fifty-five laparoscopic adrenalectomies (LA) were performed on 51 patients over eight years. The mean age was 48 years (Range 16-86 years) with the male: female ratio 1:2. Twenty-three cases had a right adrenalectomy, 24 had a left adrenalectomy and the remaining four patients had bilateral adrenalectomies. 91% were successfully completed laparoscopically with five converted to an open approach. Adenomas (functional and non functional) were the leading indication for LA, followed by phaeochromocytomas. Other indications for LA included Cushing\\'s disease, adrenal malignancies and rarer pathologies. There was one mortality from necrotising pancreatitis following a left adrenalectomy for severe Cushing\\'s disease, with subsequent death 10 days later. CONCLUSION: Laparoscopic adrenalectomy is effective for the treatment of adrenal tumours, fulfilling the criteria for the ideal minimally invasive procedure. It has replaced the traditional open approach in our centre and is a safe and effective alternative. However, in the case of severe Cushing\\'s disease, laparoscopic adrenalectomy has the potential for significant adverse outcomes and mortality.

  14. A vida como vir-a-aceitar: considerações Austinianas sobre a modernidade Life as coming-to-accept: Austin-like considerations on modernity

    Directory of Open Access Journals (Sweden)

    Fábio Luiz Lopes da Silva

    2009-01-01

    Full Text Available Austin, como se sabe, toma a existência de um procedimento convencional aceito como condição primeira de felicidade de qualquer performativo. Mas isso coloca um problema, que o filósofo inglês não chega a considerar até suas últimas conseqüências. Refiro-me ao fato de que um certo performativo - a aceitação - está inscrito na própria estrutura da performatividade. Ou seja, todo performativo exige um 'Aceito', que, por sua vez, exige um 'Aceito'- e assim ao infinito. Aceitar - essa condição de felicidade de todo performativo - é um ato, no limite, impossível de ser objetivado. Trata-se, neste ensaio, de pensar, a partir de Austin, a vida como um vir-a-aceitar, tema correlativo ao já clássico tópico da vida como vir-a-ser. Trata-se, em seguida, de pensar a forma propriamente moderna de lidar com esse vir-a-aceitar. Para tanto, vou propor uma articulação entre a filosofia austiniana e as reflexões de Calligaris (1997 sobre a modernidade.According to Austin, the first condition of happiness of a performative utterance is the existence of "an accepted conventional procedure". We have a curious situation here, and Austin recognizes it, at least in part. In fact, if a performative - the act of accepting - is inscribed in the very structure of performativity, then every performative - including accepting - presupposes an act of accepting, which, in its turn, presupposes an act of accepting, and so on. Accepting - not merely a regular performative, but a condition of the happiness of every performative - is, in the final analysis, is impossible to totalize. In this essay, following Austin's statements, I make an attempt to define life as comingto-accept, a topic analogous to the classical topic of life as coming-to-be. After this, I will try to articulate Austinian philosophy of language to Contardo Calligaris' considerations on modernity, in order to delineate the modern way of dealing with life as comingto-accept.

  15. Oil Trading Centre to Reopen in Shanghai

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    @@ Chinese oil companies will likely resume activities at the oil trading centre in Shanghai this year, a move to further liberalize the once tightly controlled oil market. The centre will trade forward contracts for refined oil products,including gasoline, diesel oil, kerosene and fuel oil, industrial sources said.

  16. Danish Anaesthesia Allergy Centre - preliminary results

    DEFF Research Database (Denmark)

    Garvey, L H; Roed-Petersen, J; Menné, T;

    2001-01-01

    BACKGROUND: Anaphylactoid reactions in anaesthesia are rare and should ideally be investigated in specialist centres. At Gentofte University Hospital, we established such a centre in 1998 as a joint venture between the Departments of Anaesthesiology and Dermatology. We present the methodology...

  17. Neighbourhood Centres – Organisation, Management and Finance

    DEFF Research Database (Denmark)

    Larsen, Jacob Norvig

    From the late 1990s neighbourhood centres were brought to the fore of public urban regen-eration policy, because they were seen as a means to accelerate the formation of social capital in deprived urban neighbourhoods. A number of such local community centres were established with substantial pub...

  18. Clinical utility of F-18 FDG PET-CT in the initial evaluation of lung cancer

    DEFF Research Database (Denmark)

    Madsen, Poul Henning; Holdgaard, Paw Christian; Christensen, Janne Buck;

    2016-01-01

    , and pre-operative evaluation, we conducted a systematic literature search, review, and quality assessment using the rapid evidence assessment toolkit and the Oxford Centre for Evidence-Based Medicine methodology. The literature search resulted in 4,208 records including 918 reviews, of which 139 met...... the predefined criteria and were read in full to identify relevant original articles on F-18 FDG PET-CT (1) in the evaluation of solitary pulmonary nodules (n = 14), (2) in curative-intent treatment trials (n = 9), and (3) in planning of invasive procedures (n = 18). RESULTS: We found the following important...

  19. The role of the sexual assault centre.

    LENUS (Irish Health Repository)

    Eogan, Maeve

    2013-02-01

    Sexual Assault Centres provide multidisciplinary care for men and women who have experienced sexual crime. These centres enable provision of medical, forensic, psychological support and follow-up care, even if patients chose not to report the incident to the police service. Sexual Support Centres need to provide a ring-fenced, forensically clean environment. They need to be appropriately staffed and available 24 hours a day, 7 days a week to allow prompt provision of medical and supportive care and collection of forensic evidence. Sexual Assault Centres work best within the context of a core agreed model of care, which includes defined multi-agency guidelines and care pathways, close links with forensic science and police services, and designated and sustainable funding arrangements. Additionally, Sexual Assault Centres also participate in patient, staff and community education and risk reduction. Furthermore, they contribute to the development, evaluation and implementation of national strategies on domestic, sexual and gender-based violence.

  20. Attenuation correction for small animal PET tomographs

    Energy Technology Data Exchange (ETDEWEB)

    Chow, Patrick L [David Geffen School of Medicine at UCLA, Crump Institute for Molecular Imaging, University of California, 700 Westwood Plaza, Los Angeles, CA 90095 (United States); Rannou, Fernando R [Departamento de Ingenieria Informatica, Universidad de Santiago de Chile (USACH), Av. Ecuador 3659, Santiago (Chile); Chatziioannou, Arion F [David Geffen School of Medicine at UCLA, Crump Institute for Molecular Imaging, University of California, 700 Westwood Plaza, Los Angeles, CA 90095 (United States)

    2005-04-21

    Attenuation correction is one of the important corrections required for quantitative positron emission tomography (PET). This work will compare the quantitative accuracy of attenuation correction using a simple global scale factor with traditional transmission-based methods acquired either with a small animal PET or a small animal x-ray computed tomography (CT) scanner. Two phantoms (one mouse-sized and one rat-sized) and two animal subjects (one mouse and one rat) were scanned in CTI Concorde Microsystem's microPET (registered) Focus{sup TM} for emission and transmission data and in ImTek's MicroCAT{sup TM} II for transmission data. PET emission image values were calibrated against a scintillation well counter. Results indicate that the scale factor method of attenuation correction places the average measured activity concentration about the expected value, without correcting for the cupping artefact from attenuation. Noise analysis in the phantom studies with the PET-based method shows that noise in the transmission data increases the noise in the corrected emission data. The CT-based method was accurate and delivered low-noise images suitable for both PET data correction and PET tracer localization.

  1. Comparing life cycle energy and GHG emissions of bio-based PET, recycled PET, PLA and man-made cellulosics

    NARCIS (Netherlands)

    Shen, L.; Worrell, E.; Patel, M.K.

    2012-01-01

    The purpose of this paper is to review the environmental profiles of petrochemical PET, (partially) bio-based PET, recycled PET, and recycled (partially) bio-based PET, and compare them with other bio-based materials, namely PLA (polylactic acid, a bio-based polyester) and man-made cellulose fibers

  2. Use of F-18 fluoro deoxyglucose (FDG) positron emission tomography (PET) in the assessment of malignant mesothelioma

    International Nuclear Information System (INIS)

    Full text: Australia has the highest mesothelioma incidence rate in the world and the incidence of Mesothelioma is increasing. Therapy for Mesothelioma involves surgery (including phototherapy), radiotherapy and chemotherapy. Computed tomography (CT) is frequently used to stage the extent of Mesothelioma. This study aimed to evaluate the utility of FDG PET in staging Mesothelioma and monitoring response to therapy. Nineteen F-18 FDG PET was performed at the A and RMC Centre for PET in 14 patients (13M: 1F, age range 39-77 years, mean age 58 years) with biopsy proven malignant pleural Mesothelioma. Patients were referred for staging (5 patients) or evaluation of patients post surgery or phototherapy (9 patients). 3 patients had more than 1 PET scan. FDG scans were reviewed with full access to the CT report. Standardised Uptake Values (SUV) were performed in all scans in regions of maximal FDG uptake corresponding to CT abnormality. Normal lung SUVs were also calculated. Follow-up was possible in all patients to the time of death or December 2001 (Follow-up 4 - 45 months, mean 16 months; 3 patients still alive). All FDG PET scans were positive for FDG-avid pleural tissue. No surgery was deferred due to FDG PET findings. In 3 patients mediastinal nodes were identified pre-surgery. Post surgical therapy assessment by FDG PET (9 patients) guided therapy by confirming disease progression or further characterising post-operative changes when CT findings were uncertain. FDG PET was able to more accurately distinguish between collapse/consolidation and recurrent disease than CT scan. Almost all post-surgical scans were performed in patients who received phototherapy. Different Mesothelioma histological subtypes could not be differentiated by SUV criteria. False positive FDG PET studies were seen in 3 patients, all of whom had post-surgical empyemas. In conclusion, FDG PET has a potential role in the management of malignant mesothelioma patients, particularly in the post

  3. Molecular Imaging in Breast Cancer: From Whole-Body PET/CT to Dedicated Breast PET

    Directory of Open Access Journals (Sweden)

    B. B. Koolen

    2012-01-01

    Full Text Available Positron emission tomography (PET, with or without integrated computed tomography (CT, using 18F-fluorodeoxyglucose (FDG is based on the principle of elevated glucose metabolism in malignant tumors, and its use in breast cancer patients is frequently being investigated. It has been shown useful for classification, staging, and response monitoring, both in primary and recurrent disease. However, because of the partial volume effect and limited resolution of most whole-body PET scanners, sensitivity for the visualization of small tumors is generally low. To improve the detection and quantification of primary breast tumors with FDG PET, several dedicated breast PET devices have been developed. In this nonsystematic review, we shortly summarize the value of whole-body PET/CT in breast cancer and provide an overview of currently available dedicated breast PETs.

  4. Pet Ownership and Evacuation Prior to Hurricane Irene

    OpenAIRE

    Nick Rohrbaugh; Kelsey Bogue; Hunt, Melissa G.

    2012-01-01

    Simple Summary Ninety pet owners and 27 non-pet owners who lived in mandatory evacuation zones during the 2011 Hurricane Irene were surveyed about whether or not they evacuated and about their experiences during the hurricane. Although pet-ownership was not statistically associated with evacuation failure, many pet owners who chose not to evacuate still claimed that they did not evacuate because of difficulties with evacuating their pet. These findings suggest that more work needs to be done ...

  5. The Heritage of Radiotracers for PET

    Science.gov (United States)

    Fowler, J. S.; Wolf, A. P.

    1988-05-01

    The history of PET research clearly demonstrates that it is advances in chemistry coupled with a detailed examination of the biochemistry of new radiotracers which has allowed the PET method to be applied to new areas of biology and medicine. Radiotracers whose regional distribution reflects glucose metabolism, neutrotransmitter activity and enzyme activity have all required the development of rapid synthetic methods for the radiotracers themselves and the characterization of their biochemical behavior. This article traces some of the advances in the production of labeled precursors and in radiotracer synthesis and evaluation which have shaped the rapidly expanding application of PET to problems in the neurosciences, in cardiology and in oncology.

  6. Recent progress of PET in Alzheimer's disease

    Directory of Open Access Journals (Sweden)

    Na NIU

    2014-03-01

    Full Text Available Alzheimer's disease is the most common cause of dementia in the current elderly population. PET can detect pathophysiological changes in Alzheimer's disease with different radiotracers. This paper will focus on evaluating the value of 18F-FDG, amyloid and tau protein PET imaging in Alzheimer's disease. PET has been demonstrated to play an important role in the research of etiology, early diagnosis, differential dignosis, prognosis and medical treatment of Alzheimer's disease. doi: 10.3969/j.issn.1672-6731.2014.03.007

  7. Advances in PET Physics and Instrumentation

    International Nuclear Information System (INIS)

    The historical development of positron emission tomography (PET) is marked by numerous significant technological accomplishments driven by an unprecedented collaboration between multi-disciplinary groups of investigators with backgrounds in medical sciences, physics, chemistry, mathematics, bioengineering, and computer science. During the last two decades, functional and metabolic imaging using PET has advanced elegantly and steadily gained importance in the clinical and research arenas. Significant progress has been made by scanner manufacturers and academic research groups in the design of dedicated high-resolution 3-D PET units; however, emerging clinical and research applications of functional brain imaging promise even greater levels of accuracy and precision and therefore impose more constraints with respect to the intrinsic performance of the PET scanner and the quantitative analysis capabilities of the provided software. The development of optimized PET detection geometries combined with high performance detector technologies and compact designs of PET scanners have become the goal of active research groups both in academic and corporate settings. Thus, there are many different design paths being pursued and it will be interesting to see what technologies become the most successful in the future. In addition to being a powerful clinical tool, PET is also used in small laboratory animal research to visualize and track certain molecular processes associated with diseases such as cancer, heart disease and neurological disorders in living small animal models of disease. During the past decade there has been substantial research and energy devoted to the development of high resolution preclinical PET systems for rodent research. This work has resulted in the development of numerous research prototypes as well as several commercially available high-resolution PET systems. The challenges of advancing PET's capabilities and some of the new imaging system

  8. Big Surveys, Big Data Centres

    Science.gov (United States)

    Schade, D.

    2016-06-01

    Well-designed astronomical surveys are powerful and have consistently been keystones of scientific progress. The Byurakan Surveys using a Schmidt telescope with an objective prism produced a list of about 3000 UV-excess Markarian galaxies but these objects have stimulated an enormous amount of further study and appear in over 16,000 publications. The CFHT Legacy Surveys used a wide-field imager to cover thousands of square degrees and those surveys are mentioned in over 1100 publications since 2002. Both ground and space-based astronomy have been increasing their investments in survey work. Survey instrumentation strives toward fair samples and large sky coverage and therefore strives to produce massive datasets. Thus we are faced with the "big data" problem in astronomy. Survey datasets require specialized approaches to data management. Big data places additional challenging requirements for data management. If the term "big data" is defined as data collections that are too large to move then there are profound implications for the infrastructure that supports big data science. The current model of data centres is obsolete. In the era of big data the central problem is how to create architectures that effectively manage the relationship between data collections, networks, processing capabilities, and software, given the science requirements of the projects that need to be executed. A stand alone data silo cannot support big data science. I'll describe the current efforts of the Canadian community to deal with this situation and our successes and failures. I'll talk about how we are planning in the next decade to try to create a workable and adaptable solution to support big data science.

  9. The Canadian Astronomy Data Centre

    Science.gov (United States)

    Ball, Nicholas M.; Schade, D.; Astronomy Data Centre, Canadian

    2011-01-01

    The Canadian Astronomy Data Centre (CADC) is the world's largest astronomical data center, holding over 0.5 Petabytes of information, and serving nearly 3000 astronomers worldwide. Its current data collections include BLAST, CFHT, CGPS, FUSE, Gemini, HST, JCMT, MACHO, MOST, and numerous other archives and services. It provides extensive data archiving, curation, and processing expertise, via projects such as MegaPipe, and enables substantial day-to-day collaboration between resident astronomers and computer specialists. It is a stable, powerful, persistent, and properly supported environment for the storage and processing of large volumes of data, a condition that is now absolutely vital for their science potential to be exploited by the community. Through initiatives such as the Common Archive Observation Model (CAOM), the Canadian Virtual Observatory (CVO), and the Canadian Advanced Network for Astronomical Research (CANFAR), the CADC is at the global forefront of advancing astronomical research through improved data services. The CAOM aims to provide homogeneous data access, and hence viable interoperability between a potentially unlimited number of different data collections, at many wavelengths. It is active in the definition of numerous emerging standards within the International Virtual Observatory, and several datasets are already available. The CANFAR project is an initiative to make cloud computing for storage and data-intensive processing available to the community. It does this via a Virtual Machine environment that is equivalent to managing a local desktop. Several groups are already processing science data. CADC is also at the forefront of advanced astronomical data analysis, driven by the science requirements of astronomers both locally and further afield. The emergence of 'Astroinformatics' promises to provide not only utility items like object classifications, but to directly enable new science by accessing previously undiscovered or intractable

  10. PET with a dual-head coincidence gamma camera in head and neck cancer: A comparison with computed tomography and dedicated PET; Stellenwert der PET mit Koinzidenz-Gammakameras bei Kopf-Hals-Tumoren: Vergleich mit Computertomographie und dedizierter PET

    Energy Technology Data Exchange (ETDEWEB)

    Zimny, M. [Technische Hochschule Aachen (Germany). Klinik fuer Nuklearmedizin

    2001-11-01

    Positron emission tomography with {sup 18}F-fluoro-deoxyglucose (FDG PET) is a promising imaging tool for detecting and staging of primary or recurrent head and neck cancer. The aim of this study was to evaluate a dual-head gamma camera modified for coincidence detection (KGK-PET) in comparison to computed tomography (CT) and dedicated PET (dPET). 50 patients with known or suspected primary or recurrent head and neck cancer were enrolled. 32 patients underwent KGK-PET and dPET using a one-day protocol. The sensitivity for the detection of primary/ recurrent head and neck cancer for KGK-PET and CT was 80% and 54%, respectively, specificity was 73% and 82%, respectively. The sensitivity and specificity for the detection of lymph node metastases based on neck sides with KGK-PET was 71% (CT: 65%) and 88% (CT: 89%) respectively. In comparison to dPET, KGK-PET revealed concordant results in 32/32 patients with respect to primary tumor/recurrent disease and in 55/60 evaluated neck sides. All involved neck sides that were missed by KGK-PET were also negative with dPET. These results indicate that in patients with head and neck cancer KGK-PET reveals information, that are similar to dPET and complementary to CT. (orig.) [German] Die Positronenemissionstomographie mit {sup 18}F-Fluor-Deoxyglukose (FDG-PET) ist ein viel versprechendes Verfahren zur Detektion und zum Staging von primaeren und rezidivierenden Malignomen der Kopf-Hals-Region. Ziel der Studie war die Evaluation einer koinzidenzfaehigen Doppelkopf-Gammakamera (KGK-PET) im Vergleich zur Computertomographie (CT) und dedizierten Ring-PET (dPET). Untersucht wurden 50 Patienten mit Kopf-Hals-Tumoren. Vergleichsuntersuchungen mit dPET erfolgten bei 32 Patienten. Die Sensitivitaet von KGK-PET zur Erkennung von Primaertumoren/Rezidiven betrug 80% bei einer Spezifitaet von 73%. Fuer CT berechnete sich eine Sensitivitaet von 54% und eine Spezifitaet von 82%. Bezueglich einer zervikalen Lymphknotenmetastasierung errechnete

  11. Molecular Imaging Challenges With PET

    CERN Document Server

    Lecoq, P

    2010-01-01

    The future trends in molecular imaging and associated challenges for in-vivo functional imaging are illustrated on the basis of a few examples, such as atherosclerosis vulnerable plaques imaging or stem cells tracking. A set of parameters are derived to define the specifications of a new generation of in-vivo imaging devices in terms of sensitivity, spatial resolution and signal-to-noise ratio. The limitations of strategies used in present PET scanners are discussed and new approaches are proposed taking advantage of recent progress on materials, photodetectors and readout electronics. A special focus is put on metamaterials, as a new approach to bring more functionality to detection devices. It is shown that the route is now open towards a fully digital detector head with very high photon counting capability over a large energy range, excellent timing precision and possibility of imaging the energy deposition process.

  12. Combined PET/MRI scanner

    Science.gov (United States)

    Schlyer, David; Woody, Craig L.; Rooney, William; Vaska, Paul; Stoll, Sean; Pratte, Jean-Francois; O'Connor, Paul

    2007-10-23

    A combined PET/MRI scanner generally includes a magnet for producing a magnetic field suitable for magnetic resonance imaging, a radiofrequency (RF) coil disposed within the magnetic field produced by the magnet and a ring tomograph disposed within the magnetic field produced by the magnet. The ring tomograph includes a scintillator layer for outputting at least one photon in response to an annihilation event, a detection array coupled to the scintillator layer for detecting the at least one photon outputted by the scintillator layer and for outputting a detection signal in response to the detected photon and a front-end electronic array coupled to the detection array for receiving the detection signal, wherein the front-end array has a preamplifier and a shaper network for conditioning the detection signal.

  13. Feasibility study for PET - The right choice for establishing PET in emerging countries

    International Nuclear Information System (INIS)

    Full text: PET represents a new step forward in evaluating function of internal organs and has proven to be very useful in Oncology, Cardiology, Neurology and in the field of infection and inflammation. In response to growing interest in the PET technology IAEA Department of the Technical Cooperation and the Institute of Pathophysiology and Nuclear Medicine from Skopje, Macedonia initiated a feasibility study for evaluation of local conditions for PET implementation in Macedonia as a part of the new project cycle (2007-2009). This paper potentially will be contribute to the challenges of establishing PET in emerging countries, because Macedonia is a part of the Members States who are still in the planning stage of acquiring clinical PET. For the purposes of this feasibility study, ''Importance of establishing PET facilities in Republic of Macedonia'' several options were evaluated, and the workframe were created. The main points of this study are: - to create a strategy for the provision of positron emission tomography in the country, including Basic principles of PET, Clinical application of PET and International status of PET; - to evaluate the current status in Macedonia and relevant health statistics for the project; - to indicate all recommendation for the further evaluation (technological and scientific issues, raw materials and supplier); - economic evaluation of diagnostic imaging technologies, including price of PET and costeffectiveness analysis; - to analyze location, infrastructural and environmental conditions, work space, organization and overhead costs; - to create the implementation scheduling and the budget for the project with financial analysis and investment evaluation; - to see current problems and their solutions; - to evaluate optimal clinical indications for PET imaging; - to estimate reimbursement for PET. Conclusion: the importance of this feasibility study is: - to show the interest for the PET implementation in republic of Macedonia

  14. Quantity and quality of runoff reduction and recharge enhancement from constructed rain gardens and vegetated retention ponds in Austin, Texas

    Science.gov (United States)

    Eljuri, A. G.; Moffett, K. B.

    2013-12-01

    Rain gardens and retention ponds are intended to reduce storm water and pollutant runoff to rivers and streams, rain gardens by enhancing infiltration and retention ponds by promoting evaporation. The City of Austin, Texas is actively investing money and time into these storm water management solutions, but there are no data comparing their effectiveness. In particular, comparisons of rain gardens against control plots and new wetland-vegetated retention pond designs against traditional grassy pond designs are lacking. This study quantifies the quantity and quality of storm runoff to and from five sites: three engineered sites, two rain gardens receiving direct runoff from the same residential roof and a planted retention pond receiving municipal parking lot runoff, and two control sites, a mulched residential lawn receiving direct roof runoff and a grassy municipal retention pond receiving parking lot runoff. A locally installed rain gauge monitors precipitation rates and we collect and analyze rainwater chemistry. Each site is instrumented with bottles to collect direct runoff samples and suction lysimeters within and below the root zone, at 10 cm and 40 cm depth, from which to collect soil water. Soil moisture sensors at 5 cm, 25 cm, and 50 cm depth are used to monitor changes in soil moisture profiles over time. Evapotranspiration rates were determined using local meteorological data and stomatal conductance measurements at the sites. Infiltrometer tests, soil characterizations, and vegetation surveys were also conducted at each site. The soil at the rain gardens are highly mixed with pebbles at the top and become a more uniform soil towards the bottom of the root zone. This differs from the control site where the soil is uniform except for the thin layer of wood chips at the surface. The water samples were analyzed for pH, dissolved organic carbon (DOC), dissolved inorganic carbon (DIC), and cations (incl. cadmium, iron, zinc, and lead) and anions (incl

  15. Design and Construction of a Solar Observatory in a Liberal Arts Environment: Austin College’s Gnomon and Meridian Line

    Science.gov (United States)

    Baker, David; Salisbury, D.

    2014-01-01

    Austin College’s indoor solar observatory is one of the most distinctive features in its new IDEA Center science building. Patterned after 16th and 17th century solar observatories in European cathedrals, the IDEA Center solar facility will be used extensively for public events, introductory astronomy courses, and reproductions of important historical scientific measurements. A circular aperture, or gnomon hole, on the roof with diameter 32 mm allows a beam of sunlight to trace a path across the atrium floor 15.37 meters below. At local solar noon, the Sun’s image falls directly on a brass meridian line. Special markers for solstices and equinoxes highlight western, eastern, and indigenous cultural contributions to astronomy: Macedonian symbol of the Sun marks summer solstice, Chinese Sun symbol showcases the equinoxes, and the Mayan symbol of the Sun celebrates winter solstice. The location directly beneath the gnomon hole is marked by the universal scientific symbol of the Sun. Direct solar measurements and mathematical models were used in design and implementation of the meridian line. During IDEA Center building construction in Fall 2012, undergraduate students measured the Sun’s position at various times. The finished floor was set in February 2013, well before a full year’s worth of measurements could be recorded. A mathematical model including the effects of aperture size and atmospheric refraction was needed to predict the size and location of the Sun on the meridian line throughout the year. Confirmation of the meridian line occurred on Summer Solstice 2013 when the Sun’s image precisely hit the Macedonian marker at the correct time.

  16. Career Outcomes for Astronomy Ph.D. Graduates of the University of Texas at Austin: The Next Generation

    Science.gov (United States)

    Dinerstein, Harriet L.

    2011-01-01

    Sixteen years ago I conducted a survey of the career trajectories and outcomes of 78 individuals who earned Ph.D.s from the Department of Astronomy at the University of Texas at Austin during the period 1984-1995 (Dinerstein, H. 1996, AAS, 189.0501). In the current poster I extend these statistics up to the present, adding 68 Ph.D. recipients from 1996-2010. This is a sufficiently large sample to search for secular trends such as possible changes in duration of the postdoctoral stage, redistribution of demographics among different kinds of long-term positions, and the emergence of new categories of astronomy-related employment. The picture is less discouraging than one might expect. As of 2010, about 75% of the Texas graduates 7 - 14 years past the Ph.D. are still doing astronomy, and most of those in non-astronomical careers left the field by choice (and often have had considerable success in their alternate careers). Of those 6 years or less past the Ph.D., 50% were in postdoctoral positions and less than 10% had left astronomy. Recent reconsiderations of the employment market (Metcalfe, T.S. 2008, PASP, 120, 229; Seth, A. 2009, Astro2010: The Astronomy and Astrophysics Decadal Survey, Position Paper No. 51) make the point that a typical astronomer who ultimately achieves a permanent position will have held two or three prior temporary positions; this was equally true three decades ago. There has been notable growth nationwide in the number of astronomers employed as faculty at small liberal arts colleges and other undergraduate-centered institutions, a trend that to some degree was anticipated by the University of Texas cohort, which included a number of students for whom this was their personal goal. In a world where job certainty is no longer so prevalent, motivated and resourceful astronomers are finding ways to remain active members of our community.

  17. Integrating Infrastructure-Relevant Climate Projections into City Planning: Learning from Boulder CO, Austin TX and Washington DC

    Science.gov (United States)

    Stoner, A. M. K.; Hayhoe, K.

    2015-12-01

    Over the coming century, climate change has the potential to impact infrastructure in many different ways, particularly in population-dense areas that depend on transportation and built environments. Many of these impacts may occur via changes in the frequency and magnitude of extremes: high and low temperature, heat waves, precipitation, coastal flooding, and storm events. Having a better idea of how the climate might change locally, both within the near future as well as toward the end of the century, can give city planners and engineers guidance when designing new structures and when repairing and fortifying existing components of buildings, bridges, highways, sewers, ports, etc. However, the type of event and the amount of damages that may be incurred are often highly specific to a given location. Over the last 10 years, we have worked with a broad range of cities, states, non-profit organizations, and federal agencies to integrate climate projections into ongoing resiliency, sustainability, and management processes. Drawing on that experience, we describe the broad steps in assimilating climate information into existing decision-making frameworks relevant to most applications, as well as highlighting many of the unique aspects of these analyses using examples from our most recent work with three very different cities - Austin TX, Boulder CO and Washington DC. From initial conversations with local experts to identify relevant thresholds to final integration of projected changes into the planning processes of these cities, these case studies highlight the utility of including future climate projections into infrastructure planning, the challenges to doing so, and the over-arching importance of communication and interaction between infrastructure experts, engineers, and scientists.

  18. Implementation of a solid target production facility

    Science.gov (United States)

    Tochon-Danguy, H. J.; Poniger, S. S.; Sachinidis, J. I.; Panopoulos, H. P.; Scott, A. M.

    2012-12-01

    The desire to utilize long-lived PET isotopes in Australia has significantly increased over the years and several research projects for labelling of peptides, proteins and biomolecules, including labelling of recombinant antibodies has been restricted due to the limited availability of suitable isotopes. This need has led to the recent installation and commissioning of a new facility dedicated to fully automated solid target isotope production, including 24I, 64Cu, 89Zr and 86Y at the Austin Health Centre for PET.

  19. Business administration of PET facilities. A nationwide survey for prices of PET screening and a cost analysis of three facilities

    International Nuclear Information System (INIS)

    The purpose of this study is to analyze the business administration of positron emission tomography (PET) facilities based on the survey of the price of PET cancer screening and cost analysis of PET examination. The questionnaire survey of the price of PET cancer screening was implemented for all PET facilities in Japan. Cost data of PET examination, including fixed costs and variable costs, were obtained from three different medical institutions. The marked price of the PET cancer screening was yen111,499 in average, and the most popular range of prices was between yen80,000 and yen90,000. Costs of PET per examination were accounted for yen110,675, yen79,158 and yen111,644 in facility A, B and C, respectively. The results suggested that facilities with two or more PET/CT per a cyclotron could only secure profits. In Japan, the boom in PET facility construction could not continue in accordance with increasing number of PET facilities. It would become more essential to analyze the appropriate distribution of PET facilities and the adequate amount of PET procedures from the perspective of efficient utilization of the PET equipments and supply of PET-related healthcare. (author)

  20. Processing and characterization of extruded PET and its r-PET and MWCNT nanocomposite thin films by spin coating

    Indian Academy of Sciences (India)

    Arvind R Singh; Vineeta D Deshpande

    2016-02-01

    The objective of the present study was basic understanding of the formation of thin film morphology by spin coating using reorganized polyethylene terephthalate (r-PET) and multiwalled carbon nanotubes (MWCNTs) as fillers in PET. A study of the correlation between physical properties of the PET films and its surface morphology was carried out using atomic force microscopy-based power spectral density (PSD) analysis. No significant work of surface analysis, using PSD of thin films of PET has been reported till date. Dilute solution of PET, PET with 3 wt% (r-PET) and PET with 3 wt% (2 wt% r-PET + 1 wt% MWCNT) filler were prepared using trifluoroacetic acid (TFA) as a solvent and thin films were fabricated on glass substrate by the optimized spin coating technique. Preparation of r-PET and r-PET+ MWCNT fillers was obtained by the precipitation method using TFA as a solvent and acetone as an antisolvent. The samples before spin coating were extruded and for comparison, a film of non-extruded PET was also prepared. Structural studies by Fourier transform infrared and X-ray diffraction show higher degree of crystallinity in r-PET and decrease in chain entanglements. Owing to the crystallizing behaviour of r-PET, it allows better dispersion of MWCNT in the polymer matrix as compared with PET. The samples with fillers of MWCNT show more compact and unique mesh-like globular structure, indicating application for electromagnetic shielding foams and fibres.

  1. Review of CERN Data Centre Infrastructure

    CERN Document Server

    Andrade, P; van Eldik, J; McCance, G; Panzer-Steindel, B; Coelho dos Santos, M; Traylen, S; Schwickerath, U

    2012-01-01

    The CERN Data Centre is reviewing strategies for optimizing the use of the existing infrastructure and expanding to a new data centre by studying how other large sites are being operated. Over the past six months, CERN has been investigating modern and widely-used tools and procedures used for virtualisation, clouds and fabric management in order to reduce operational effort, increase agility and support unattended remote data centres. This paper gives the details on the project’s motivations, current status and areas for future investigation.

  2. Review of CERN Data Centre Infrastructure

    Science.gov (United States)

    Andrade, P.; Bell, T.; van Eldik, J.; McCance, G.; Panzer-Steindel, B.; Coelho dos Santos, M.; Traylen and, S.; Schwickerath, U.

    2012-12-01

    The CERN Data Centre is reviewing strategies for optimizing the use of the existing infrastructure and expanding to a new data centre by studying how other large sites are being operated. Over the past six months, CERN has been investigating modern and widely-used tools and procedures used for virtualisation, clouds and fabric management in order to reduce operational effort, increase agility and support unattended remote data centres. This paper gives the details on the project's motivations, current status and areas for future investigation.

  3. Bacterial Zoonoses Transmitted by Household Pets

    DEFF Research Database (Denmark)

    Damborg, Peter Panduro; Broens, E.M.; Chomel, B.B.;

    2016-01-01

    The close contact between household pets and people offers favourable conditions for bacterial transmission. In this article, the aetiology, prevalence, transmission, impact on human health and preventative measures are summarized for selected bacterial zoonoses transmissible by household pets. Six...... zoonoses representing distinct transmission routes were selected arbitrarily based on the available information on incidence and severity of pet-associated disease caused by zoonotic bacteria: bite infections and cat scratch disease (physical injuries), psittacosis (inhalation), leptospirosis (contact...... with urine), and campylobacteriosis and salmonellosis (faecal–oral ingestion). Antimicrobial resistance was also included due to the recent emergence of multidrug-resistant bacteria of zoonotic potential in dogs and cats. There is a general lack of data on pathogen prevalence in the relevant pet population...

  4. FDG PET/CT in cancer

    DEFF Research Database (Denmark)

    Petersen, Henrik; Holdgaard, Paw Christian; Madsen, Poul Henning;

    2016-01-01

    use of PET/CT in the RSD with these recommendations. This article summarizes the results. METHODS: A Work Group appointed a professional Subgroup which made Clinician Groups conduct literature reviews on six selected cancers responsible for 5,768 (62.6 %) of 9,213 PET/CT scans in the RSD in 2012......-recommendable" indications, respectively. RESULTS: Of 11,729 citations, 1,729 were considered for review, and 204 were included. The evidence suggested usefulness of PET/CT in lung, lymphoma, melanoma, head and neck, and colorectal cancers, whereas evidence was sparse in gynaecological cancers. The agreement between actual...... use of PET/CT and literature-based recommendations was high in the first five mentioned cancers in that 96.2 % of scans were made for grade A or B indications versus only 22.2 % in gynaecological cancers. CONCLUSION: Evidence-based usefulness was reported in five of six selected cancers; evidence...

  5. PET scanning in plastic and reconstructive surgery

    International Nuclear Information System (INIS)

    In this report we highlight the use of position emission tomography (PET) scan in plastic and reconstructive surgery. PET scanning is a very important tool in plastic surgery oncology (melanoma, soft-tissue sarcomas and bone sarcomas, head and neck cancer, peripheral nerve sheath tumors of the extremities and breast cancer after breast esthetic surgery), as diagnosis, staging, treatment planning and follow-up of cancer patients is based on imaging. PET scanning seems also to be useful as a flap monitoring system as well as an infection's imaging tool, for example in the management of diabetic foot ulcer. PET also contributes to the understanding of pathophysiology of keloids which remain a therapeutic challenge. (author)

  6. Cardiovascular physiology and diseases of pet birds.

    Science.gov (United States)

    Pees, Michael; Krautwald-Junghanns, Maria-Elisabeth

    2009-01-01

    Avian cardiac disease in pet birds occurs more often than previously assumed. The article focuses on anatomic peculiarities of the avian cardiovascular system and common diseases. Diagnostic possibilities are demonstrated, and therapeutic measures are discussed.

  7. Quantitative analysis of PET measurements in tumors

    International Nuclear Information System (INIS)

    The positron emission tomograhpy (PET) has been used for the evaluation of the characteristics of various tumors. The role of PET in oncology has been evolved from a pure research tool to a methodology of enormous clinical potential. The unique characteristics of PET imaging make sophisticated quantitation possible. Several quantitative methods, such as standardized uptake values (SUV), simplifield quantitation method, Patlak graphical analysis, and Sokoloff's glucose metabolism measurement, have been used in the field of oncology. However, each quantitative method has limitations of its own. For example, the SUV has been used as a quantitative index of glucose metabolism for tumor classification and monitoring response to treatment, even though it depends on blood glucose level, body configuration of patient, and scanning time. The quantitative methods of PET are reviewed and strategy for implementing these methods are presented

  8. FDG-PET/CT findings in systemic mastocytosis: a French multicentre study

    International Nuclear Information System (INIS)

    Mastocytosis is a clonal haematological disease characterized by uncontrolled proliferation and the activation of mast cells. The value of FDG-PET/CT (FDG-PET) in mastocytosis has yet to be determined. We retrospectively identified patients with an established diagnosis of systemic mastocytosis (SM), according to the WHO criteria, who underwent PET using the French Reference Centre for Mastocytosis database. Semi-quantitative and visual analysis of FDG-PET was performed and compared to the clinico-biological data. Our cohort included 19 adult patients, median age 65 years [range 58-74], including three with smouldering SM (SSM), three with aggressive SM (ASM), 10 with an associated clonal haematological non-mast-cell lineage disease (SM-AHNMD), and three with mast cell sarcoma (MCS). FDG-PET was performed at the time of the SM diagnosis (15/19), to evaluate lymph node (LN) activity (3/19) or the efficacy of therapy (1/19). FDG uptake was observed in the bone marrow (BM) (9/19, 47 %), LN (6/19, 32 %), spleen (12/19, 63 %), or liver (1/19, 5 %). No significant FDG uptake was observed in the SSM and ASM patients. A pathological FDG uptake was observed in the BM of 6/10 patients with SM-AHNMD, appearing as diffuse and homogeneous, and in the LN of 5/10 patients. All 3 MCS patients showed intense and multifocal BM pathological uptake, mimicking metastasis. No correlation was found between the FDG-PET findings and serum tryptase levels, BM mast cell infiltration percentage, and CD30 and CD2 expression by mast cells. FDG uptake does not appear to be a sensitive marker of mast cell activation or proliferation because no significant FDG uptake was observed in most common forms of mastocytosis (notably purely aggressive SM). However, pathological FDG uptake was observed in the SM-AHNMD and in MCS cases, suggesting a role of FDG-PET in their early identification and as a tool of therapeutic assessment in this subgroup of patients. (orig.)

  9. FDG-PET/CT findings in systemic mastocytosis: a French multicentre study

    Energy Technology Data Exchange (ETDEWEB)

    Djelbani-Ahmed, S. [Assistance Publique - Hopitaux de Paris (APHP), Department of Nuclear Medicine, Avicenne Hospital, Bobigny (France); Paris 13 University, Sorbonne Paris Cite, Bobigny (France); Chandesris, M.O. [Necker Children' s Hospital, APHP, French Reference center for Mastocytosis (Centre de Reference des Mastocytoses, CEREMAST), Paris (France); Necker Children' s Hospital, APHP, Department of Haematology, Paris (France); Paris Descartes University, Sorbonne Paris Cite, Imagine Institute, Paris (France); Mekinian, A.; Fain, O. [Saint Antoine Hospital, Department of Internal Medicine and Inflammation-Immunopathology-Biotherapy Department (DHU i2B), AP-HP, Paris (France); Canioni, D. [Necker Children' s Hospital, APHP, French Reference center for Mastocytosis (Centre de Reference des Mastocytoses, CEREMAST), Paris (France); Paris Descartes University, Sorbonne Paris Cite, Imagine Institute, Paris (France); Necker Children' s Hospital, APHP, Department of Pathology, Paris (France); Brouzes, C. [Necker Children' s Hospital, APHP, French Reference center for Mastocytosis (Centre de Reference des Mastocytoses, CEREMAST), Paris (France); Paris Descartes University, Sorbonne Paris Cite, Imagine Institute, Paris (France); Necker Children' s Hospital, APHP, Laboratory of Haematology, Paris (France); Hanssens, K. [Necker Children' s Hospital, APHP, French Reference center for Mastocytosis (Centre de Reference des Mastocytoses, CEREMAST), Paris (France); Aix-Marseille University, INSERM U1068, Centre de Recherche en Cancerologie de Marseille (Signaling, Hematopoiesis and Mechanism of Oncogenesis), Paoli Calmettes Institute, Marseille (France); Pop, G.; Eder, V. [Assistance Publique - Hopitaux de Paris (APHP), Department of Nuclear Medicine, Avicenne Hospital, Bobigny (France); Durieu, I.; Durupt, S. [Universite de Lyon, Department of Internal and Vascular Medicine, Hospices Civils de Lyon, Groupe Hopitalier Sud, Pierre-Benite (France); Grosbois, B.; Besnard, S. [Rennes University Hospital, Department of Internal Medicine, Rennes (France); Tournilhac, O. [Clermont-Ferrand University Hospital, Department of Internal Medicine, Clermont-Ferrand (France); Beyne-Rauzy, O. [Purpan University Hospital, Department of Internal Medicine, Toulouse (France); Agape, P. [Saint-Denis University Hospital, Department of Oncology and Haematology, Saint-Denis de la Reunion (France); Delmer, A. [Reims University Hospital, Department of Haematology, Reims (France); Ranta, D. [Brabois University Hospital, Department of Haematology, Vandoeuvre les Nancy (France); Jeandel, P.Y. [Nice University Hospital, Department of Internal Medicine, Nice (France); Georgin-Lavialle, S. [Tenon Hospital, Department of Internal Medicine, Paris (France); Frenzel, L.; Hermine, O. [Necker Children' s Hospital, APHP, French Reference center for Mastocytosis (Centre de Reference des Mastocytoses, CEREMAST), Paris (FR); Necker Children' s Hospital, APHP, Department of Haematology, Paris (FR); Paris Descartes University, Sorbonne Paris Cite, Imagine Institute, Paris (FR); Damaj, G. [Necker Children' s Hospital, APHP, French Reference center for Mastocytosis (Centre de Reference des Mastocytoses, CEREMAST), Paris (FR); Caen University Hospital, Department of Haematology, Caen (FR); Lortholary, O. [Necker Children' s Hospital, APHP, French Reference center for Mastocytosis (Centre de Reference des Mastocytoses, CEREMAST), Paris (FR); Paris Descartes University, Sorbonne Paris Cite, Imagine Institute, Paris (FR); Pasteur Institute, Department of Infectious Diseases and Tropical Medicine, Necker Children' s Hospital, APHP, Paris (FR); Soussan, M. [Assistance Publique - Hopitaux de Paris (APHP), Department of Nuclear Medicine, Avicenne Hospital, Bobigny (FR); Paris 13 University, Sorbonne Paris Cite, Bobigny (FR)

    2015-12-15

    Mastocytosis is a clonal haematological disease characterized by uncontrolled proliferation and the activation of mast cells. The value of FDG-PET/CT (FDG-PET) in mastocytosis has yet to be determined. We retrospectively identified patients with an established diagnosis of systemic mastocytosis (SM), according to the WHO criteria, who underwent PET using the French Reference Centre for Mastocytosis database. Semi-quantitative and visual analysis of FDG-PET was performed and compared to the clinico-biological data. Our cohort included 19 adult patients, median age 65 years [range 58-74], including three with smouldering SM (SSM), three with aggressive SM (ASM), 10 with an associated clonal haematological non-mast-cell lineage disease (SM-AHNMD), and three with mast cell sarcoma (MCS). FDG-PET was performed at the time of the SM diagnosis (15/19), to evaluate lymph node (LN) activity (3/19) or the efficacy of therapy (1/19). FDG uptake was observed in the bone marrow (BM) (9/19, 47 %), LN (6/19, 32 %), spleen (12/19, 63 %), or liver (1/19, 5 %). No significant FDG uptake was observed in the SSM and ASM patients. A pathological FDG uptake was observed in the BM of 6/10 patients with SM-AHNMD, appearing as diffuse and homogeneous, and in the LN of 5/10 patients. All 3 MCS patients showed intense and multifocal BM pathological uptake, mimicking metastasis. No correlation was found between the FDG-PET findings and serum tryptase levels, BM mast cell infiltration percentage, and CD30 and CD2 expression by mast cells. FDG uptake does not appear to be a sensitive marker of mast cell activation or proliferation because no significant FDG uptake was observed in most common forms of mastocytosis (notably purely aggressive SM). However, pathological FDG uptake was observed in the SM-AHNMD and in MCS cases, suggesting a role of FDG-PET in their early identification and as a tool of therapeutic assessment in this subgroup of patients. (orig.)

  10. Dynamic neurotransmitter interactions measured with PET

    International Nuclear Information System (INIS)

    Positron emission tomography (PET) has become a valuable interdisciplinary tool for understanding physiological, biochemical and pharmacological functions at a molecular level in living humans, whether in a healthy or diseased state. The utility of tracing chemical activity through the body transcends the fields of cardiology, oncology, neurology and psychiatry. In this, PET techniques span radiochemistry and radiopharmaceutical development to instrumentation, image analysis, anatomy and modeling. PET has made substantial contributions in each of these fields by providing a,venue for mapping dynamic functions of healthy and unhealthy human anatomy. As diverse as the disciplines it bridges, PET has provided insight into an equally significant variety of psychiatric disorders. Using the unique quantitative ability of PET, researchers are now better able to non-invasively characterize normally occurring neurotransmitter interactions in the brain. With the knowledge that these interactions provide the fundamental basis for brain response, many investigators have recently focused their efforts on an examination of the communication between these chemicals in both healthy volunteers and individuals suffering from diseases classically defined as neurotransmitter specific in nature. In addition, PET can measure the biochemical dynamics of acute and sustained drug abuse. Thus, PET studies of neurotransmitter interactions enable investigators to describe a multitude of specific functional interactions in the human brain. This information can then be applied to understanding side effects that occur in response to acute and chronic drug therapy, and to designing new drugs that target multiple systems as opposed to single receptor types. Knowledge derived from PET studies can be applied to drug discovery, research and development (for review, see (Fowler et al., 1999) and (Burns et al., 1999)). Here, we will cover the most substantial contributions of PET to understanding

  11. Dynamic neurotransmitter interactions measured with PET

    Energy Technology Data Exchange (ETDEWEB)

    Schiffer, W.K.; Dewey, S.L.

    2001-04-02

    Positron emission tomography (PET) has become a valuable interdisciplinary tool for understanding physiological, biochemical and pharmacological functions at a molecular level in living humans, whether in a healthy or diseased state. The utility of tracing chemical activity through the body transcends the fields of cardiology, oncology, neurology and psychiatry. In this, PET techniques span radiochemistry and radiopharmaceutical development to instrumentation, image analysis, anatomy and modeling. PET has made substantial contributions in each of these fields by providing a,venue for mapping dynamic functions of healthy and unhealthy human anatomy. As diverse as the disciplines it bridges, PET has provided insight into an equally significant variety of psychiatric disorders. Using the unique quantitative ability of PET, researchers are now better able to non-invasively characterize normally occurring neurotransmitter interactions in the brain. With the knowledge that these interactions provide the fundamental basis for brain response, many investigators have recently focused their efforts on an examination of the communication between these chemicals in both healthy volunteers and individuals suffering from diseases classically defined as neurotransmitter specific in nature. In addition, PET can measure the biochemical dynamics of acute and sustained drug abuse. Thus, PET studies of neurotransmitter interactions enable investigators to describe a multitude of specific functional interactions in the human brain. This information can then be applied to understanding side effects that occur in response to acute and chronic drug therapy, and to designing new drugs that target multiple systems as opposed to single receptor types. Knowledge derived from PET studies can be applied to drug discovery, research and development (for review, see (Fowler et al., 1999) and (Burns et al., 1999)). Here, we will cover the most substantial contributions of PET to understanding

  12. The establishment of the Rossendorf PET Center

    International Nuclear Information System (INIS)

    The objectives of the newly established Positron Emission Tomography (PET) Center at the Institut of Bioinorganic and Radiopharmaceutical Chemistry in Rossendorf are described, referring to medical research, development of tracers and radiochemicals developments, biochemistry and future prospects of PET in Rossendorf. The layout of the center is also described considering the cyclotron and targetry, the transport system, the radiopharmaceutical laboratories and the tomograph. A schedule for project development is going. (BBR)

  13. The history of cerebral PET scanning

    Science.gov (United States)

    Portnow, Leah H.; Vaillancourt, David E.; Okun, Michael S.

    2013-01-01

    Objective: To review the discoveries underpinning the introduction of cerebral PET scanning and highlight its modern applications. Background: Important discoveries in neurophysiology, brain metabolism, and radiotracer development in the post–World War II period provided the necessary infrastructure for the first cerebral PET scan. Methods: A complete review of the literature was undertaken to search for primary and secondary sources on the history of PET imaging. Searches were performed in PubMed, Google Scholar, and select individual journal Web sites. Written autobiographies were obtained through the Society for Neuroscience Web site at www.sfn.org. A reference book on the history of radiology, Naked to the Bone, was reviewed to corroborate facts and to locate references. The references listed in all the articles and books obtained were reviewed. Results: The neurophysiologic sciences required to build cerebral PET imaging date back to 1878. The last 60 years have produced an evolution of technological advancements in brain metabolism and radiotracer development. These advancements facilitated the development of modern cerebral PET imaging. Several key scientists were involved in critical discoveries and among them were Angelo Mosso, Charles Roy, Charles Sherrington, John Fulton, Seymour Kety, Louis Sokoloff, David E. Kuhl, Gordon L. Brownell, Michael Ter-Pogossian, Michael Phelps, and Edward Hoffman. Conclusions: Neurophysiology, metabolism, and radiotracer development in the postwar era synergized the development of the technology necessary for cerebral PET scanning. Continued use of PET in clinical trials and current developments in PET-CT/MRI hybrids has led to advancement in diagnosis, management, and treatment of neurologic disorders. PMID:23460618

  14. Pathophysiology of movement disorders studied using PET

    International Nuclear Information System (INIS)

    PET radiotracer methods can measure various biochemical features ol brain tissue in the living human brain. Here, local brain energy consumption and striatal dopaminergic function will be discussed in the light of the neurodegenerative processes underlying Parkinson's disease. Particularly. disease progression and its consequences for protective and restorative strategies will be outlined. Also, an example will be given to demonstrate how the effect of neurotrophic factors on the striatal dopaminergic system can be monitored by PET tracer methods. (author)

  15. PET/MRI. Methodology and clinical applications

    Energy Technology Data Exchange (ETDEWEB)

    Carrio, Ignasi [Autonomous Univ. of Barcelona, Hospital Sant Pau (Spain). Dept. Medicina Nuclear; Ros, Pablo (ed.) [Univ. Hospitals Case, Medical Center, Cleveland, OH (United States). Dept. of Radiology

    2014-04-01

    Provides detailed information on the methodology and equipment of MRI-PET. Covers a wide range of clinical applications in oncology, cardiology, and neurology. Written by an international group of experts in MRI and PET. PET/MRI is an exciting novel diagnostic imaging modality that combines the precise anatomic and physiologic information provided by magnetic resonance imaging (MRI) with the molecular data obtained with positron emission tomography (PET). PET/MRI offers the promise of a simplified work flow, reduced radiation, whole-body imaging with superior soft tissue contrast, and time of flight physiologic information. It has been described as the pathway to molecular imaging in medicine. In compiling this textbook, the editors have brought together a truly international group of experts in MRI and PET. The book is divided into two parts. The first part covers methodology and equipment and comprises chapters on basic molecular medicine, development of specific contrast agents, MR attenuation and validation, quantitative MRI and PET motion correction, and technical implications for both MRI and PET. The second part of the book focuses on clinical applications in oncology, cardiology, and neurology. Imaging of major neoplasms, including lymphomas and tumors of the breast, prostate, and head and neck, is covered in individual chapters. Further chapters address functional and metabolic cardiovascular examinations and major central nervous system applications such as brain tumors and dementias. Risks, safety aspects, and healthcare costs and impacts are also discussed. This book will be of interest to all radiologists and nuclear medicine physicians who wish to learn more about the latest developments in this important emerging imaging modality and its applications.

  16. Sea otter health: Challenging a pet hypothesis.

    Science.gov (United States)

    Lafferty, Kevin D

    2015-12-01

    A recent series of studies on tagged sea otters (Enhydra lutris nereis) challenges the hypothesis that sea otters are sentinels of a dirty ocean, in particular, that pet cats are the main source of exposure to Toxoplasma gondii in central California. Counter to expectations, sea otters from unpopulated stretches of coastline are less healthy and more exposed to parasites than city-associated otters. Ironically, now it seems that spillover from wildlife, not pets, dominates spatial patterns of disease transmission. PMID:26155464

  17. Determining Block Detector Positions for PET Scanners

    OpenAIRE

    Pierce, Larry; Miyaoka, Robert; Lewellen, Tom; Alessio, Adam; Kinahan, Paul

    2009-01-01

    We present an algorithm for accurate localization of block detectors in a positron emission tomography (PET) scanner. Accurate reconstruction of PET images requires precise knowledge of the physical position and orientation of the detectors. However, in some systems, block detector positioning and orientation can have relatively large tolerances, leading to implicit errors in the coincidence line-of-response (LOR) positioning. To compensate we utilize a rotating point source phantom where the...

  18. Towards Human-Centred Design

    Science.gov (United States)

    Bannon, Liam J.

    The field of HCI has evolved and expanded dramatically since its origin in the early 1980’s. The HCI community embraces a large community of researchers and practitioners around the world, from a variety of disciplinary backgrounds in the human and social sciences, engineering and informatics, and more recently, the arts and design disciplines. This kaleidoscope of cultures and disciplines as seen at INTERACT Conferences provides a rich pool of resources for examining our field. Applications are increasingly exploring our full range of sensory modalities, and merging the digital and physical worlds. WiFi has opened up a huge design space for mobile applications. A focus on usability of products and services has been complemented by an emphasis on engagement, enjoyment and experience. With the advent of ubiquitous computing, and the emergence of “The Internet of Things”, new kinds of more open infrastructures make possible radically new kinds of applications. The sources of innovation have also broadened, to include human and social actors outside of the computing and design organizations. The question is to what extent is our mainstream thinking in the HCI field ready for the challenges of this Brave New World? Do the technological and social innovations that we see emerging require us to re-shape, or even, re-create, our field, or is it a case of a more gradual evolution and development of that which we already know? In this closing Keynote, I will provide a perspective on the evolution and development of the HCI field, looking backwards as well as forwards, in order to determine what are some of the changes of significance in the field. This “broad-brush” approach to what I term “ human-centred design” will be complemented by the examination of specific projects and applications, to help anchor some of the discussion. Areas such as user-centred design, participatory design, computer-supported cooperative work and learning, and interaction design, in

  19. PeneloPET, a Monte Carlo PET simulation tool based on PENELOPE: features and validation

    Energy Technology Data Exchange (ETDEWEB)

    Espana, S; Herraiz, J L; Vicente, E; Udias, J M [Grupo de Fisica Nuclear, Departmento de Fisica Atomica, Molecular y Nuclear, Universidad Complutense de Madrid, Madrid (Spain); Vaquero, J J; Desco, M [Unidad de Medicina y CirugIa Experimental, Hospital General Universitario Gregorio Maranon, Madrid (Spain)], E-mail: jose@nuc2.fis.ucm.es

    2009-03-21

    Monte Carlo simulations play an important role in positron emission tomography (PET) imaging, as an essential tool for the research and development of new scanners and for advanced image reconstruction. PeneloPET, a PET-dedicated Monte Carlo tool, is presented and validated in this work. PeneloPET is based on PENELOPE, a Monte Carlo code for the simulation of the transport in matter of electrons, positrons and photons, with energies from a few hundred eV to 1 GeV. PENELOPE is robust, fast and very accurate, but it may be unfriendly to people not acquainted with the FORTRAN programming language. PeneloPET is an easy-to-use application which allows comprehensive simulations of PET systems within PENELOPE. Complex and realistic simulations can be set by modifying a few simple input text files. Different levels of output data are available for analysis, from sinogram and lines-of-response (LORs) histogramming to fully detailed list mode. These data can be further exploited with the preferred programming language, including ROOT. PeneloPET simulates PET systems based on crystal array blocks coupled to photodetectors and allows the user to define radioactive sources, detectors, shielding and other parts of the scanner. The acquisition chain is simulated in high level detail; for instance, the electronic processing can include pile-up rejection mechanisms and time stamping of events, if desired. This paper describes PeneloPET and shows the results of extensive validations and comparisons of simulations against real measurements from commercial acquisition systems. PeneloPET is being extensively employed to improve the image quality of commercial PET systems and for the development of new ones.

  20. The additional value of PET/CT over PET in FDG imaging of oesophageal cancer

    Energy Technology Data Exchange (ETDEWEB)

    Bar-Shalom, Rachel; Frenkel, Alex [Rambam Medical Center, Department of Nuclear Medicine, Haifa (Israel); Guralnik, Ludmila; Leiderman, Max [Rambam Medical Center, Department of Diagnostic Imaging, Haifa (Israel); Tsalic, Medy [Rambam Medical Center, Department of Oncology, Haifa (Israel); Gaitini, Diana [Rambam Medical Center, Department of Diagnostic Imaging, Haifa (Israel); School of Medicine, Israel Institute of Technology, Haifa (Israel); Ben-Nun, Alon [Rambam Medical Center, Department of Thoracic Surgery, Haifa (Israel); Keidar, Zohar; Israel, Ora [Rambam Medical Center, Department of Nuclear Medicine, Haifa (Israel); School of Medicine, Israel Institute of Technology, Haifa (Israel)

    2005-08-01

    The aim of this study was to assess the value of combined PET/CT compared with PET reviewed side-by-side with CT, in patients with oesophageal cancer, before and after surgery. Forty-one FDG PET/CT studies were performed in 32 patients with oesophageal cancer, before surgery (n=18) or during follow-up after resection of the primary tumour (n=23). One hundred and fifteen sites suspicious for malignancy were evaluated. PET/CT was prospectively compared with PET reviewed side-by-side with CT, for detection, accurate localisation and characterisation of malignant sites. PET/CT performance in different anatomical regions was compared before and after surgery. The impact of fused data on patient management was retrospectively assessed. PET/CT had an incremental value over PET for interpretation of 25 of 115 sites (22%), changing the initial characterisation of ten sites to either malignant (n=1) or benign (n=9), and defining the precise anatomical location of 15 sites. PET/CT provided better specificity and accuracy than PET for detecting sites of oesophageal cancer (81% and 90% vs 59% and 83% respectively, p<0.01). Fusion was of special value for interpretation of cervical and abdomino-pelvic sites, for disease assessment in loco-regional lymph nodes before surgery and in regions of postoperative anatomical distortion. PET/CT had an impact on the further management of four patients (10%), by detecting nodal metastases that warranted disease upstaging (n=2) and by excluding disease in sites of benign uptake after surgery (n=2). (orig.)

  1. PET-CT: accuracy of PET and CT spatial registration of lung lesions

    International Nuclear Information System (INIS)

    PET-CT scanners offer the unique ability to acquire PET and CT data with rapid full body registration. The purpose of this study was to evaluate the accuracy of spatial registration between PET and CT data in patients with fluorine-18 fluoro-2-deoxy-D-glucose (FDG)-avid lung lesions. PET, CT and fused PET-CT images from 244 consecutive clinical patients undergoing whole-body FDG PET-CT imaging (GE Discovery LS, CT attenuation correction, OSEM reconstruction) were evaluated. Inclusion criteria for this analysis were lung lesions clearly defined on both PET and CT, lesion diameter less than 5 cm and clear borders. Patients were allowed to breathe freely during both PET and CT image acquisitions. The spatial coordinates of the visually estimated centers of the lesion were determined independently for PET and CT images and compared. Thirty-six patients (26 females, 10 males) with a total of 48 lesions were included (19 lung cancer patients with 26 lesions, 17 patients with 22 lung metastases). The average lung lesion diameter was 15.6±9 mm. The mean distance between the center of lesions independently determined for both PET and CT was 7.55±4.73 mm. Misregistration tended to be more pronounced in the lower lungs (10.2±6.55 mm) than in the upper lungs (6.67±4.28 mm) (P=0.063). Misregistration also tended to be slightly more pronounced in the left lung (8.33±5.05 mm) than in the right lung (6.25±3.92 mm) (P=0.059). In conclusion, with a dedicated PET-CT scanner and this clinically practical imaging algorithm, registration is usually accurate, but spatial misregistration of primary lung lesions does occur. (orig.)

  2. A comparative study of PET and PET/CT in solitary pulmonary nodules

    International Nuclear Information System (INIS)

    Objective To investigate the diagnostic accuracy of PET/CT in solitary pulmonary nodule(SPN) and compare it with PET. Methods: 60 cases of SPN (30 benigns, 30 malignants) confirmed by pathology (n=47) and follow-up (n=13) underwent PET/CT. The diagnoses of malignant SPN in PET images were made by two nuclear medicine doctors with a criterion of standardized uptake value (SUV)≥2.5. Two experienced radiologists and the two nuclear medicine doctors worked together and analyzed PET/CT images by the evidence of SUV and morphological signs in CT such as lobulation, short spiculation, acantha, vacuole or cavity, calcification, pleural indentation, bronchus truncation, texture collection and satellites. The frequency of all signs were compared statistically between benign and malignant SPN with χ2 test. Results: According to the criterion of SUV≥2.5 as malignant the sensitivity, specificity and accuracy of PET were 86.7%, 90.0% and 88.3% whereas in PET/CT were 90.0%, 93.3% and 91.7%, respectively. The main frequency of 5 malignant CT signs of SPN were in order of short spiculation (63.3%), bronchus truncation (50.0%), acantha (46.7%), typical lobulation (36.7%) and pleural indentation (26.7%). All of them were significantly different between benign and malignant (P<0.05). In 7 misdiagnose PET images, 4 cases being changed therapeutic regime after PET/CT, among them 2 with correct diagnose, 2 equivocal needed further follow-up. Conclusion: The diagnostic accuracy of SPN is further improved by PET/CT as PET alone. (authors)

  3. Reproducibility of 18F-FDG PET uptake measurements in head and neck squamous cell carcinoma on both PET/CT and PET/MR

    Science.gov (United States)

    Fischer, B M; Aznar, M C; Hansen, A E; Vogelius, I R; Löfgren, J; Andersen, F L; Loft, A; Kjaer, A; Højgaard, L; Specht, L

    2015-01-01

    Objective: To investigate reproducibility of fluorine-18 fludeoxyglucose (18F-FDG) uptake on 18F-FDG positron emission tomography (PET)/CT and 18F-FDG PET/MR scans in patients with head and neck squamous cell carcinoma (HNSCC). Methods: 30 patients with HNSCC were included in this prospective study. The patients were scanned twice before radiotherapy treatment with both PET/CT and PET/MR. Patients were scanned on the same scanners, 3 days apart and according to the same protocol. Metabolic tumour activity was measured by the maximum and peak standardized uptake value (SUVmax and SUVpeak, respectively), and total lesion glycolysis from the metabolic tumour volume defined from ≥50% SUVmax. Bland–Altman analysis with limits of agreement, coefficient of variation (CV) from the two modalities were performed in order to test the reproducibility. Furthermore, CVs from SUVmax and SUVpeak were compared. The area under the curve from cumulative SUV–volume histograms were measured and tested for reproducibility of the distribution of 18F-FDG uptake. Results: 24 patients had two pre-treatment PET/CT scans and 21 patients had two pre-treatment PET/MR scans available for further analyses. Mean difference for SUVmax, peak and mean was approximately 4% for PET/CT and 3% for PET/MR, with 95% limits of agreement less than ±20%. CV was small (5–7%) for both modalities. There was no significant difference in CVs between PET/CT and PET/MR (p = 0.31). SUVmax was not more reproducible than SUVpeak (p = 0.09). Conclusion: 18F-FDG uptake in PET/CT and PET/MR is highly reproducible and we found no difference in reproducibility between PET/CT and PET/MR. Advances in knowledge: This is the first report to test reproducibility of PET/CT and PET/MR. PMID:25634069

  4. Can body volume be determined by PET?

    Energy Technology Data Exchange (ETDEWEB)

    Hentschel, Michael; Paul, Dominik; Mix, Michael; Moser, Ernst; Brink, Ingo [University Hospital Freiburg, Division of Nuclear Medicine, Section of Positron Emission Tomography, Freiburg (Germany); Korsten-Reck, Ulrike [University Hospital Freiburg, Division of Sports Medicine, Freiburg (Germany); Mueller, Frank [PET-Institute Rhein-Neckar, Ludwigshafen (Germany); Merk, Stefan [Kantonsspital Basel, Division of Nuclear Medicine, Basel (Switzerland)

    2005-04-01

    To avoid dependence on body weight, the standardised uptake value (SUV) in positron emission tomography (PET) can instead be normalised to the lean body mass (LBM), which can be determined from body volume and mass. This study was designed to answer the following questions: Firstly, can the total body volume in principle be determined using PET? Secondly, is the precision of this measurement comparable to that achieved using an established standard method. Ten patients were examined during oncological whole-body PET examinations. The whole-body volume of the patients was determined from the transmission scan in PET. Air displacement plethysmography with BOD POD was used for comparison as the standard method of volume determination. In all patients, the whole-body volumes could be determined using PET and the standard method. Bland and Altman [23] analysis for agreement between the volumes determined by the two methods (presentation of differences vs means) revealed a very small difference of -0.14 l. With a mean patient volume of 71.81{+-}15.93 l, the relative systematic error is only <0.1%. On this basis, equality of the volume values determined by the two methods can be assumed. PET can be used as a supplementary method for experimental determination of whole-body volume and total body fat in tumour patients. The fat content can be used to calculate the LBM and to determine body weight-independent SUVs (SUV{sub LBM}). (orig.)

  5. PET in diagnosing exocrine pancreatic cancer

    International Nuclear Information System (INIS)

    Despite dramatic improvements in diagnostic imaging (ultrasonography, in particular endoscopic ultrasound, CT, MRI) treatment results of pancreatic cancer are still poor. Due to the lack of early symptoms, most tumors are diagnosed at an advanced stage of disease which excludes curative surgical treatment. FDG-PET has been shown to be effective in detecting pancreatic cancer as well as differentiating benign from malignant pancreatic tumors. Results might be further improved by applying quantitative analyses, in particular kinetic modelling of FDG metabolism. Nevertheless false negative as well as false positive findings may occur. Small lesions (lymphnode or liver metastases < 1 cm) might be missed, furthermore hyperglycemia often present in patients with pancreatic disease might reduce tumor uptake and subsequently tumor detectability by PET. False positive findings were reported in active pancreatitis and some benign tumors. Although PET proved to be superior to CT or ERCP in detecting cancer, clinical relevance of PET is limited due to the absence of therapeutic consequences to be derived from PET. As a consequence PET should only be used in patients with equivocal findings of morphological imaging (CT, ERCP) who are potential candidates for surgical treatment. (orig.)

  6. PET and SPECT imaging in veterinary medicine.

    Science.gov (United States)

    LeBlanc, Amy K; Peremans, Kathelijne

    2014-01-01

    Veterinarians have gained increasing access to positron emission tomography (PET and PET/CT) imaging facilities, allowing them to use this powerful molecular imaging technique for clinical and research applications. SPECT is currently being used more in Europe than in the United States and has been shown to be useful in veterinary oncology and in the evaluation of orthopedic diseases. SPECT brain perfusion and receptor imaging is used to investigate behavioral disorders in animals that have interesting similarities to human psychiatric disorders. This article provides an overview of the potential applications of PET and SPECT. The use of commercially available and investigational PET radiopharmaceuticals in the management of veterinary disease has been discussed. To date, most of the work in this field has utilized the commercially available PET tracer, (18)F-fluorodeoxyglucose for oncologic imaging. Normal biodistribution studies in several companion animal species (cats, dogs, and birds) have been published to assist in lesion detection and interpretation for veterinary radiologists and clinicians. Studies evaluating other (18)F-labeled tracers for research applications are underway at several institutions and companion animal models of human diseases are being increasingly recognized for their value in biomarker and therapy development. Although PET and SPECT technologies are in their infancy for clinical veterinary medicine, increasing access to and interest in these applications and other molecular imaging techniques has led to a greater knowledge and collective body of expertise for veterinarians worldwide. Initiation and fostering of physician-veterinarian collaborations are key components to the forward movement of this field.

  7. Symmetric centres of braided monoidal categories

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    This paper introduces the concept of‘symmetric centres' of braided monoidal categories. Let H be a Hopf algebra with bijective antipode over a field k. We address the symmetric centre of the Yetter-Drinfel'd module category HH(yD) and show that a left Yetter-Drinfel'd module M belongs to the symmetric centre of HH(yD) if and only if M is trivial. We also study the symmetric centres of categories of representations of quasitriangular Hopf algebras and give a sufficient and necessary condition for the braid of H(M) to induce the braid of (H(H)(A),(○)A,A,φ,l,r), or equivalently, the braid of (A#H(H),(○)A,A,φ,l,r), where A is a quantum commutative H-module algebra.

  8. The relativistic two-centre continuum

    International Nuclear Information System (INIS)

    A method is presented to define unique continuum states for the two-centre Dirac Hamiltonian. In the spherical limit these states become the familiar angular momentum eigenstates of the radial Coulomb potential. The different states for a fixed total energy vertical strokeEvertical stroke > m may be distinguished by considering the asymptotic spin-angular distribution of states with unique scattering-phases. First numerical solutions of the two-centre Dirac equation for continuum states are presented. (orig.)

  9. INFOTERM – Information Disseminating Centre for Terminology

    OpenAIRE

    Albina Auksoriūtė

    2014-01-01

    International Information Centre for Terminology (INFOTERM) was founded in 1971 by contract with the United Nations Educational, Scientific and Cultural Organization (UNESCO) and the Austrian Standards Institute (ASI). In 1996, INFOTERM was reorganized and established as an independent non-profit organization. INFOTERM promotes and supports the cooperation of existing and the establishment of new terminology centres and networks with the general aim to improve domain communication, knowledge ...

  10. Two centre problems in relativistic atomic physics

    OpenAIRE

    McConnell, Sean R.

    2012-01-01

    The work contained within this thesis is concerned with the explanation and usage of a set of theoretical procedures for the study of static and dynamic two–centre problems in the relativistic framework of Dirac’s equation. Two distinctly different theories for handling time–dependent atomic interactions are reviewed, namely semi–classical perturbation theory and a non–perturbative numerical technique based on the coupled channel equation to directly solve the time–dependent, two–centre Dirac...

  11. Joint Research Centre. Ispra establishment-Italy

    International Nuclear Information System (INIS)

    A comprehensive review of the work carried out during 1974 and 1975 in the Ispra establishment of the Joint Research Centre is presented. A description of the activity carried out within the context of the running programmes is given. Some of the most relevant scientific and technical achievement are described from the viewpoints of the Scientific Departments of the Centre. The technical and administrative support activities are also presented. A list of publications issued by the Ispra Scientific staff is given

  12. Social innovation for People-Centred Development

    DEFF Research Database (Denmark)

    Hulgård, Lars; P.K., Shajahan

    2013-01-01

    Social innovation is closely related to the people-centred development (PCD) framework of knowledge production. The discussion of PCD in this chapter particularly expands on the feature of empowerment and socio-political mobilization of people in social innovation......Social innovation is closely related to the people-centred development (PCD) framework of knowledge production. The discussion of PCD in this chapter particularly expands on the feature of empowerment and socio-political mobilization of people in social innovation...

  13. Perspectives on recycling centres and future developments.

    Science.gov (United States)

    Engkvist, I-L; Eklund, J; Krook, J; Björkman, M; Sundin, E

    2016-11-01

    The overall aim of this paper is to draw combined, all-embracing conclusions based on a long-term multidisciplinary research programme on recycling centres in Sweden, focussing on working conditions, environment and system performance. A second aim is to give recommendations for their development of new and existing recycling centres and to discuss implications for the future design and organisation. Several opportunities for improvement of recycling centres were identified, such as design, layout, ease with which users could sort their waste, the work environment, conflicting needs and goals within the industry, and industrialisation. Combining all results from the research, which consisted of different disciplinary aspects, made it possible to analyse and elucidate their interrelations. Waste sorting quality was recognized as the most prominent improvement field in the recycling centre system. The research identified the importance of involving stakeholders with different perspectives when planning a recycling centre in order to get functionality and high performance. Practical proposals of how to plan and build recycling centres are given in a detailed checklist. PMID:26826952

  14. Imaging corn plants with PhytoPET, a modular PET system for plant biology

    Energy Technology Data Exchange (ETDEWEB)

    Lee, S.; Kross, B.; McKisson, J.; McKisson, J. E.; Weisenberger, A. G.; Xi, W.; Zorn, C.; Bonito, G.; Howell, C. R.; Reid, C. D.; Crowell, A.; Cumberbatch, L. C.; Topp, C.; Smith, M. F.

    2013-11-01

    PhytoPET is a modular positron emission tomography (PET) system designed specifically for plant imaging. The PhytoPET design allows flexible arrangements of PET detectors based on individual standalone detector modules built from single Hamamatsu H8500 position sensitive photomultiplier tubes and pixelated LYSO arrays. We have used the PhytoPET system to perform preliminary corn plant imaging studies at the Duke University Biology Department Phytotron. Initial evaluation of the PhytoPET system to image the biodistribution of the positron emitting tracer {sup 11}C in corn plants is presented. {sup 11}CO{sub 2} is loaded into corn seedlings by a leaf-labeling cuvette and translocation of {sup 11}C-sugars is imaged by a flexible arrangement of PhytoPET modules on each side. The PhytoPET system successfully images {sup 11}C within corn plants and allows for the dynamic measurement of {sup 11}C-sugar translocation from the leaf to the roots.

  15. Imaging with {sup 124}I in differentiated thyroid carcinoma: is PET/MRI superior to PET/CT?

    Energy Technology Data Exchange (ETDEWEB)

    Binse, I.; Poeppel, T.D.; Ruhlmann, M.; Gomez, B.; Bockisch, A.; Rosenbaum-Krumme, S.J. [University of Duisburg-Essen, Medical Faculty, Department of Nuclear Medicine, Essen (Germany); Umutlu, L. [University of Duisburg-Essen, Medical Faculty, Department of Radiology, Essen (Germany)

    2016-06-15

    The aim of this study was to compare integrated PET/CT and PET/MRI for their usefulness in detecting and categorizing cervical iodine-positive lesions in patients with differentiated thyroid cancer using {sup 124}I as tracer. The study group comprised 65 patients at high risk of iodine-positive metastasis who underwent PET/CT (low-dose CT scan, PET acquisition time 2 min; PET/CT{sub 2}) followed by PET/MRI of the neck 24 h after {sup 124}I administration. PET images from both modalities were analysed for the numbers of tracer-positive lesions. Two different acquisition times were used for the comparisons, one matching the PET/CT{sub 2} acquisition time (2 min, PET/MRI{sub 2}) and the other covering the whole MRI scan time (30 min, PET/MRI{sub 30}). Iodine-positive lesions were categorized as metastasis, thyroid remnant or inconclusive according to their location on the PET/CT images. Morphological information provided by MRI was considered for evaluation of lesions on PET/MRI and for volume information. PET/MRI{sub 2} detected significantly more iodine-positive metastases and thyroid remnants than PET/CT{sub 2} (72 vs. 60, p = 0.002, and 100 vs. 80, p = 0.001, respectively), but the numbers of patients with at least one tumour lesion identified were not significantly different (21/65 vs. 17/65 patients). PET/MRI{sub 30} tended to detect more PET-positive metastases than PET/MRI{sub 2} (88 vs. 72), but the difference was not significant (p = 0.07). Of 21 lesions classified as inconclusive on PET/CT, 5 were assigned to metastasis or thyroid remnant when evaluated by PET/MRI. Volume information was available in 34 % of iodine-positive metastases and 2 % of thyroid remnants on PET/MRI. PET/MRI of the neck was found to be superior to PET/CT in detecting iodine-positive lesions. This was attributed to the higher sensitivity of the PET component, Although helpful in some cases, we found no substantial advantage of PET/MRI over PET/CT in categorizing iodine

  16. Medication errors: pharmacovigilance centres in detection and prevention

    OpenAIRE

    Bencheikh, Rachida Soulaymani; Benabdallah, Ghita

    2009-01-01

    Detecting medication errors needs collaboration between various organizations, such as patient safety institutions, pharmacovigilance centres, and poison control centres. In order to evaluate the input of pharmacovigilance centres and poison control centres in detecting and evaluating medication errors a pilot project was initiated by the World Alliance for Patient Safety in collaboration with the Uppsala Monitoring Centre; the Moroccan pharmacovigilance centre acted as project coordinator. A...

  17. FDG-PET identification of intraperitoneal metastases

    International Nuclear Information System (INIS)

    Aim: Peritoneal metastases (PM) are usually from intra-abdominal primary neoplasms, such as carcinoma of the stomach, colon, ovary, and pancreas, or from intra-abdominal lymphoma. Metastases disseminate throughout the peritoneum in four ways: 1) direct spread along peritoneal ligaments, mesenteries and omenta; 2) via the flow of ascitis fluid. 3) lymphatic extension, and 4) embolic hematogenous spread. Although CT is quite specific in identifying PM it is not very sensitive, and peritoneal lavage or biopsy can be very useful but have sampling errors. This study assessed the clinical value of FDG-PET for the detection of PM of malignant diseases. Materials and Methods: 15 FDG-PET scans of patients referred for recurrence (mean age = 54 y/o, sex = 6M, 9F), with metabolic abnormalities suspicious findings of PM from carcinoma of the colon (7), ovary (3), lymphoma (2), pancreas (1), gastrointestinal stromal tumor (1) and melanoma (1) were reviewed. The whole-body studies were performed 50 min following the intravenous administration of 370 MBq of 18F-FDG, in a high resolution dedicated PET scanner (Advance, GEMS), with images reconstructed using a iterative algorithm with segmented attenuation correction. Visual interpretation and SUV values were correlated with CT/MRI findings and biopsy/follow-up. Results: Of the 15 patients, 7 showed <3 sites of focal uptake and 8 presented multiple foci or a diffuse hypermetabolism in the abdomen (SUVmax3.04-18.83 g/ml). 6 patients had biopsy confirmation by PET-directed surgery (6 proven PM, 0 negative biopsies). 11 FDG-PET scans had correspondence with the CT/MRI findings and 4 showed discrepancies (PET positive-CT/MRI negative in patients with isolated raising tumor markers levels or unsuspected PM). FDG-PET influenced the therapeutic management in 2 patients as presented multiple metastases leading them from surgery to chemotherapy. Conclusion: When used as a complementary imaging tool to the conventional work up, FDG-PET is

  18. Is the detection rate of 18F-choline PET/CT influenced by androgen-deprivation therapy?

    Energy Technology Data Exchange (ETDEWEB)

    Chondrogiannis, Sotirios; Marzola, Maria Cristina; Grassetto, Gaia; Maffione, Anna Margherita; Rampin, Lucia; Rubello, Domenico [' ' Santa Maria della Misericordia' ' Hospital, Rovigo (Italy). PET/CT Centre; Ferretti, Alice [' ' San Giacomo Apostolo' ' Hospital, Castelfranco Veneto, Treviso (Italy). Service of Medical Physics; Fanti, Stefano [Azienda Ospedaliero-Univ. Policlinico S. Orsola-Malpighi, Bologna (Italy). Dept. of Nuclear Medicine; Giammarile, Francesco [Lyon 1 Univ. Centre Hospitalier Lyon Sud Biophysique, Villeurbanne (Italy). Dept. of Nuclear Medicine

    2014-07-15

    To evaluate if the detection rate (DR) of {sup 18}F-choline (18F-CH) PET/CT is influenced by androgen-deprivation therapy (ADT) in patients with prostate cancer (PC) already treated with radical intent and presenting biochemical relapse. We have retrospectively evaluated {sup 18}F-CH PET/CT scans of 325 consecutive PC patients enrolled in the period November 2009 to December 2012 previously treated with radical intent and referred to our centre to perform {sup 18}F-CH PET/CT for biochemical relapse. Two different groups of patients were evaluated. group A included the whole sample of 325 patients (mean age 70 years, range: 49-86) who presented trigger PSA between 0.1 and 80 ng/ml (mean 5.5 ng/ml), and group B included 187 patients (mean age 70 years, range 49-86) with medium-low levels of trigger PSA ranging between 0.5 and 5 ng/ml (mean PSA 2.1 ng/ml); group B was chosen in order to obtain a more homogeneous group of patients in terms of PSA values also excluding both very low and very high PSA levels avoiding the ''a priori'' higher probability of negative or positive PET scan, respectively. At the time of examination, 139 patients from group A and 72 patients from group B were under ADT: these patients were considered to be hormone-resistant PC patients because from their oncologic history (>18 months) an increase of PSA levels emerged despite the ongoing ADT. The relationship between {sup 18}F-CH PET/CT findings and possible clinical predictors was investigated using both univariate and multivariate binary logistic regression analyses, including trigger PSA and ADT. Considering the whole population, overall DR of {sup 18}F-CH PET was 58.2 % (189/325 patients). In the whole sample of patients (group A), both at the univariate and multivariate logistic regression analysis, trigger PSA and ADT were significantly correlated with the DR of {sup 18}F-CH PET (p < 0.05). Moreover, the DR in patients under ADT (mean PSA 7.8 ng/ml) was higher than in

  19. PET/CT in lymphoma patients; PET-CT bei Lymphompatienten

    Energy Technology Data Exchange (ETDEWEB)

    Steinert, H.C. [Universitaetsspital Zuerich, Klinik und Poliklinik fuer Nuklearmedizin (Switzerland)

    2004-11-01

    First results of PET/CT in Hodgkin's disease (HD) and aggressive non-Hodgkin's lymphoma (NHL) are reported. From March 2001 to August 2004 822 PET/CT were performed at our clinic in lymphoma patients for primary staging, restaging after therapy, and diagnosis of recurrence. For coregistration non contrast-enhanced low-dose CT were used. Due to the exact anatomic localization of {sup 18}F-FDG accumulating lesions equivocal or false positive PET findings are avoided. In comparison to contrast enhanced CT, PET/CT has a higher sensitivity and specificity in patients with HD and aggressive NHL. Integration of PET/CT in treatment planning of radiation therapy optimizes the field volume. Even in the initial phase of clinical evaluation, PET/CT has proven useful in staging and restaging of lymphoma. The exact anatomic localization of the PET findings is essential for a precise report, for treatment planning of radiation therapy, and for planning surgical biopsy. (orig.) [German] Erste Ergebnisse der PET-CT bei Morbus Hodgkin (HD) und den aggressiven Non-Hodgkin-Lymphomen (NHL) werden beschrieben. Von Maerz 2001 bis August 2004 wurden 822 PET-CT bei Lymphompatienten zum primaeren Staging, zum Restaging nach Therapie und zur Rezidivdiagnostik an unserer Klinik durchgefuehrt. Fuer die Koregistration wurde ein Low-dose-CT ohne i.v.-Kontrastmittel verwendet. Durch die exakte anatomische Zuordnung der {sup 18}F-FDG aufnehmenden Laesionen wurden unklare oder falsch-positive PET-Befunde vermieden. Die PET-CT erzielte im Vergleich zur KM-verstaerkten CT eine hoehere Sensitivitaet und Spezifitaet bei Patienten mit HD und aggressiven NHL. Die Integration der PET-CT in die Planung der Strahlentherapie fuehrte zu einer Optimierung der Feldgrenzen. Die PET-CT hat sich bereits in der Phase der initialen klinischen Evaluation als wertvoll beim Staging und Restaging von Lymphomen erwiesen. Die exakte anatomische Zuordnung der PET-Informationen ist fuer eine sichere Befundung

  20. PET and PET-CT. State of the art and future prospects; PET e PET- TC. Stato dell'arte e prospettive future

    Energy Technology Data Exchange (ETDEWEB)

    Fanti, Stefano; Franchi, Roberto [Policlinico S. Orsola-Malpighi, Bologna (Italy). U.O. di medicina legale; Battista, Giuseppe; Monetti, Nino; Canini, Romeo [Bologna Univ., Bologna (Italy). Dipartimento clinico di scienze radiologiche e istocitopatologiche

    2005-07-15

    Fluoro-deoxyglucose positron emission tomography (FDG PET) enables the in vivo study of tissue metabolism, and thus is able to identify malignant tumours as hypermetabolic lesions by an increase in tracer uptake. Many papers have demonstrated both the relevant impact of FDG PET on staging of many cancers and the superior accuracy of the technique compared with conventional diagnostic methods for pre-treatment evaluation, therapy response evaluation and relapse identification. In particular PET was found useful in identifying lymph nodal and metastatic spread. thus altering patient management in more than 30% of cases. PET images, however, provide limited anatomical data, which in regions such as the head and neck, mediastinum and pelvic cavity is a significant drawback. The exact localization of lesions may also be difficult in some cases, on the basis of PET images alone. The introduction of combined PET-computed tomography (PET-CT) scanners enables the almost simultaneous acquisition of transmission and emission images, thus obtaining optimal fusion images in a very short time. PET-CT fusion images enable lesions to be located, reducing false positive studies and increasing accuracy; the overall duration of examination may also be reduced. On the basis of both literature data and our experience we established the clinical indications when PET-CT may be particularly useful, in comparison with PET alone. It should also be underlined that the use of PET-CT is almost mandatory for new traces such as C-choline and C-methionine; these new tracers may be applied for studying tumours not assessable with FDG, such as prostate cancer. In conclusion PET-CT is at present the most advanced method for metabolic imaging, and is capable of precisely localizing and assessing tumours; fusion images reduce false positive and inconclusive studies, thus increasing diagnostic accuracy. [Italian] La PET con FDG F-18 ha consentito di studiare il metabolismo dei tessuti in vivo e di

  1. FDG PET or PET/CT in evaluation of renal angiomyolipoma

    Energy Technology Data Exchange (ETDEWEB)

    Lin, Chun Yi [Dept. of Nuclear Medicine, Show Chwan Memorial Hospital, Changhua (China); Chen, Hui Yi [Dept. of Radiology, China Medical University Hospital, Taichung (China); Ding, Hueisch Jy [Dept. of Nuclear Medicine, E-DA Hospital I-Shou University, Kaohsiung (China); Yen, Kuo Yang; Kao, Chia Hung [Dept. of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung (China)

    2013-04-15

    Angiomyolipoma is the most common benign kidney tumor. However, literature describing FDG PET findings on renal angiomyolipoma (AML) is limited. This study reports the FDG PET and PET/CT findings of 21 cases of renal AML. The study reviews FDG PET and PET/CT images of 21 patients diagnosed with renal AML. The diagnosis is based on the classical appearance of an AML on CT scan with active surveillance for 6 months. The study is focused on the observation of clinical and radiographic features. Six men and 15 women were included in our study. The mean age of the patients was 57.14 ± 9.67 years old. The mean diameter of 21 renal AML on CT scans was 1.76 ± 1.00 cm (Min: 0.6 cm; Max: 4.4 cm). CT scans illustrated renal masses typical of AMLs, and the corresponding FDG PET scans showed minimal FDG activities in the area of the tumors. None of the 21 AMLs showed a maximum standardized uptake value (SUV{sub max}) greater than 1.98. No statistically significant correlation was present between SUV{sub max} and tumor size. Renal AMLs demonstrate very low to low uptake on FDG PET and PET/CT imaging in this study. When a fat-containing tumor in the kidney is found on a CT scan, it is critical to differentiate an AML from a malignant tumor including an RCC, liposarcoma, and Wilms tumor. This study suggests that FDG PET or PET/CT imaging is useful for differentiating a renal AML from a fat-containing malignant tumor.

  2. Present and future of PET and PET/CT in gynaecologic malignancies

    Energy Technology Data Exchange (ETDEWEB)

    Musto, Alessandra [Department of Nuclear Medicine, PET Center, Policlinico Sant' Orsola Malpighi, Bologna University, Bologna (Italy); Rampin, Lucia [Department of Nuclear Medicine, PET Center, Radiology, Medical Physics, Santa Maria della Misericordia Hospital, viale tre martiri 140, 45100 Rovigo (Italy); Nanni, Cristina [Department of Nuclear Medicine, PET Center, Policlinico Sant' Orsola Malpighi, Bologna University, Bologna (Italy); Marzola, Maria Cristina [Department of Nuclear Medicine, PET Center, Radiology, Medical Physics, Santa Maria della Misericordia Hospital, viale tre martiri 140, 45100 Rovigo (Italy); Fanti, Stefano [Department of Nuclear Medicine, PET Center, Policlinico Sant' Orsola Malpighi, Bologna University, Bologna (Italy); Rubello, Domenico, E-mail: domenico.rubello@libero.it [Department of Nuclear Medicine, PET Center, Radiology, Medical Physics, Santa Maria della Misericordia Hospital, viale tre martiri 140, 45100 Rovigo (Italy)

    2011-04-15

    Objectives: To review the published data in literature on patients affected by gynaecological malignancies to establish the role of {sup 18}F-FDG positron emission tomography (PET) and PET/CT in comparison to conventional imaging (CI). Materials and methods: All papers specifically addressed to the role of {sup 18}F-FDG PET and PET/CT in gynaecological malignancies published on PubMed/Medline, in abstracts from the principal international congresses, in the guidelines from national Societies that had appeared in literature until November 2009 were considered for the purpose of the present study. Results and conclusions: The use of {sup 18}F-FDG PET, and even more of {sup 18}F-FDG PET/CT, is increasing in the follow up of patients with gynaecologic malignancies and suspected recurrent disease: there is evidence in the literature that {sup 18}F-FDG PET/CT has a higher sensitivity than CI in depicting occult metastatic spread. An interesting issue is represented by patients with ovarian cancer with an increase of the specific biomarker, CA-125, and negative/inconclusive findings at CI. The use of {sup 18}F-FDG PET in differential diagnosis and staging is more controversial, but there is some evidence that a baseline PET examination performed before commencing therapy, for staging purpose, is also useful to evaluate the response to chemoradiation treatment. In several papers it has been suggested a relevant role of {sup 18}F-FDG PET/CT in evaluating the entity of response to treatment and therefore to plan the subsequent therapeutic strategy.

  3. PET in the diagnosis of colorectal cancer; PET in der Diagnostik des kolorektalen Karzinoms

    Energy Technology Data Exchange (ETDEWEB)

    Dresel, S.; Rosa, F.; Scher, B. [Klinik und Poliklinik fuer Nuklearmedizin, Ludwig-Maximilians-Univ., Muenchen (Germany)

    2003-06-01

    [F-18]FDG PET is an established imaging modality in a wide variety of oncologic diseases. The primary diagnosis is usually performed with endoscopic procedures. However, in the pretherapeutic staging [F-18]FDG PET is helpful to clearly stage the patient's disease in order to plan the best therapeutic approach and allow for a correct patient management. Particularly when metastatic disease to the liver is present, [F-18]FDG PET is indispensable for a proper treatment of planning on curative resection. Also with [F-18]FDG PET extrahepatic lesions can be effectively ruled out or confirmed to avoid unnecessary surgery. For restaging in terms of diagnosing local recurrence [F-18]FDG PET has proven to be superior to morphological methods. (orig.) [German] Die [F-18]FDG-PET ist bei eine Vielzahl onkologischer Applikationen etabliert. Die Primaerdiagnostik des kolorektalen Karzinoms ist die Domaene endoskopischer Verfahren. Doch bereits zu diesem Zeitpunkt ist der Einsatz der [F-18]FDG-PET im Rahmen des Stagings sinnvoll, um das therapeutische Vorgehen in Abhaengigkeit vom Stadium der Erkrankung zu planen und so ein sinnvolles Patientenmanagement zu ermoeglichen. Insbesondere bei Vorhandensein einer Lebermetastasierung ist heute die [F-18]FDG-PET zur Planung einer Resektion der Laesionen mit moeglicherweise kurativem Ansatz unverzichtbar. Umgekehrt koennen mit der [F-18]FDG-PET in Ganzkoerpertechnik extrahepatische Herde mit hoher diagnostischer Sicherheit ausgeschlossen oder nachgewiesen werden, um in letzterem Fall unnoetige operative Eingriffe zu vermeiden. Fuer das Restaging hat sich die [F-18]FDG-PET zum Nachweis eines Lokalrezidivs als den morphologischen Verfahren ueberlegen bewaehrt. (orig.)

  4. Comparison of national PET radiopharmaceutical regulations

    International Nuclear Information System (INIS)

    In the United States (US), the European Union (EU) and Japan, physicians frequently prescribe formulations of drugs for patient care which are not available commercially, and require compounding. In the practice of Nuclear Medicine, Positron Emission Tomography (PET) presents a unique compounding challenge in the production of PET radiopharmaceuticals (RaPh), due to the short radionuclide half-lives [F-18 (110 minutes), C-11 (20 minutes), N-13 (10 minutes) and 0-15 (2 minutes)], and the need to maintain high quality standards for human use ''drugs'', particularly intravenous formulations. As PET has progressed and the utilization of PET increases each country is developing regulations to manage cyclotron radionuclide production, compounding and quality control (QC). Production of PET radionuclides in the US is currently regulated by the Nuclear Regulatory Commission (NRC). These radionuclides are then synthetically incorporated into the final PET RaPh for subsequent patient administration. Since these 'drugs' are usually administered intravenously, the regulations for sterile compounding, or manufacturing, come under Pharmacy Practice, which for the US is the Food and Drug Administration (FDA). On receipt of a physician's order for a PET drug, pharmacists (or chemists) working under the authority and supervision of a physician, or a pharmacist working in a centralized PET Nuclear Pharmacy (licensed by an individual State), can compound the PET drug and dispense it for the patient. In 2005, the US FDA published a proposed rule in the Federal Register on Current Good Manufacturing Practice (CGMP) for PET Drug Products [1]. These regulations are intended to ensure that PET drugs meet the requirements of the FDA Modernization Act (FDAMA) regarding safety, identity, strength, quality, and purity. These regulations will be included in the Code of Federal Regulation. After the rule is published, each site will have 2 years to comply with the new regulations, and to file a

  5. Transmission of HIV in dialysis centre.

    Science.gov (United States)

    Velandia, M; Fridkin, S K; Cárdenas, V; Boshell, J; Ramirez, G; Bland, L; Iglesias, A; Jarvis, W

    1995-06-01

    In August, 1993, 13 dialysis patients at one dialysis centre in Colombia, South America, were found to be HIV positive, and this prompted an epidemiological investigation. We carried out a cohort study of all dialysis centre patients during January, 1992 to December, 1993 (epidemic period) to determine risk factors for HIV seroconversion. Haemodialysis and medical records were reviewed, dialysis centre staff and surviving patients were interviewed, and dialysis practices were observed. Stored sera from all dialysis centre patients were tested for HIV antibody. 12 (52%) of 23 patients tested positive for HIV antibody by enzyme immunoassay and western blot during the epidemic period. Of the 23 tested, 9 (39%) converted from HIV antibody negative to positive (seroconverters) and 10 (44%) remained HIV negative (seronegatives). The HIV seroconversion rate was higher among patients dialysed at the centre while a new patient, who was HIV seropositive, was dialysed there (90% vs 0%; p dialysis centre reprocessed access needles, dialysers, and bloodlines (60% vs 0%). While 2 of 9 HIV seroconverters had had sex with prostitutes, none had received unscreened blood products or had other HIV risk factors. No surgical or dental procedures were associated with HIV seroconversion. Dialysers were reprocessed separately with 5% formaldehyde and were labelled for use on the same patient. Access needles were reprocessed by soaking them in a common container with a low-level disinfectant, benzalkonium chloride; 4 pairs of needles were placed in one pan creating the potential for cross-contamination or use of one patient's needles on another patient. HIV transmission at the dialysis centre was confirmed. Improperly reprocessed patient-care equipment, most probably access needles, is the likely mechanism of transmission. This outbreak was discovered by accident and similar transmission may be occurring in many other countries where low-level disinfectants are used to sterilise critical

  6. FDG-PET and PET/CT in the diagnostic work-up of breast cancer

    International Nuclear Information System (INIS)

    In screening mammography is the best method, followed by biopsy in suspect findings. Ultrasound is used in combination with mammography. In difficult cases like preoperative exclusion of multicentric disease, silicon implants and differentation between scar and local recurrence MRI has gained widespread acceptation. Scintimammography may be useful in nondiagnostic or equivocal findings in mammography due to dense breast parenchyma to monitor neoadjuvant chemotherapy of LABC, but is not recommended for routine use. FDG-PET showed to have a high sensitivity in the diagnosis of primary breast cancer. But there are limitations in the detection of tumors smaller than 10 mm and of lobular carcinomas. For screening its accuracy does not appear sufficient. FDG-PET may help improving the diagnosis of primary breast cancer in particular cases. The diagnostic accuracy of FDG-PET axillary lymph node staging has shown to be not sufficient. Especially small or micrometastases are missed frequently due to the low spatial resolution of PET. Diagnostic accuracy is not high enough to replace histopathological evaluation after surgical (sentinel) lymph node dissection. In the diagnosis of distant lymphatic and hematological metastases a high sensitivity and specificity of PET was reported. FDG-PET may be useful in staging women with high risk of presenting metastases like women with locally advanced breast cancer, but is not implemented in clinical routine, yet. FDG-PET shows a high potential to predict the therapeutic outcome of neoadjuvant chemotherapy very early and with high accuracy. But PET fails to detect microscopic residual tumor in case of complete clinical response. In the diagnosis of local recurrence PET is only useful in equivocal findings in mammography due to breast implant or posttherapeutic scars. A high sensitivity and specificity of FDG-PET in diagnosing metastases was reported. Especially in case of unclearly elevated tumor markers PET is recommended

  7. PET application in psychiatry and psychopharmacology

    Energy Technology Data Exchange (ETDEWEB)

    Suhara, Tetsuya [National Inst. of Radiological Sciences, Chiba (Japan)

    1999-07-01

    In the last few decades diagnostic and research tools in the medical field have made great advances, yet psychiatry has lacked sufficiently sensitive tools to measure the aberration of brain functions. Recently however, the development of Positron emission tomography (PET) techniques has made it possible to measure changes in neurochemical components in mental disorders and the effect of psychoactive drugs in living human brain. Most of the advancement in the psychiatric field has came from the development psychoactive drugs. Brain research involving identification of neurotransmission is largely based on compounds developed in psychopharmacology. Some of these compounds have been radiolabelled and used as radioligands for quantitative examination of neuroreceptors and other aspects of neurotransmission. Using PET, radioligand binding can now be examined in the human brain in vivo. PET techniques also allow examination of an unlabelled drug by examination of its interaction with a radioligand. So one potential of PET in psychiatry is to investigate the mechanism of psychoactive drugs. Antidepressants modulate serotonin transmission by inhibiting serotonin reuptake from the synaptic cleft. High affinity [{sup 3}H]imipramine binding sites in mammalian brain have been labelled to investigate serotonin transporters in living human brain by PET. Cyanoimipramine which is described as a potent serotonin reuptake inhibitor, was labelled with {sup 11}C. In a PET experiment with 6 healthy human subjects, a high accumulation of [{sup 11}C]cyanoimipramine was found in the thalamus and striatum and lowest accumulation was observed in the cerebellum, a region relatively void of serotonin transporters. The thalamus to cerebellum ratio was about 2 at 90 min after the injection of the tracer. Recently, [{sup 11}C]McN5652-X has been introduced as a better tracer for serotonin transporter imaging. Employing [{sup 11}C]McN5652-X in a PET study of 7 healthy human subjects, a high

  8. Fully 3D GPU PET reconstruction

    Energy Technology Data Exchange (ETDEWEB)

    Herraiz, J.L., E-mail: joaquin@nuclear.fis.ucm.es [Grupo de Fisica Nuclear, Departmento Fisica Atomica, Molecular y Nuclear, Universidad Complutense de Madrid (Spain); Espana, S. [Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA (United States); Cal-Gonzalez, J. [Grupo de Fisica Nuclear, Departmento Fisica Atomica, Molecular y Nuclear, Universidad Complutense de Madrid (Spain); Vaquero, J.J. [Departmento de Bioingenieria e Ingenieria Espacial, Universidad Carlos III, Madrid (Spain); Desco, M. [Departmento de Bioingenieria e Ingenieria Espacial, Universidad Carlos III, Madrid (Spain); Unidad de Medicina y Cirugia Experimental, Hospital General Universitario Gregorio Maranon, Madrid (Spain); Udias, J.M. [Grupo de Fisica Nuclear, Departmento Fisica Atomica, Molecular y Nuclear, Universidad Complutense de Madrid (Spain)

    2011-08-21

    Fully 3D iterative tomographic image reconstruction is computationally very demanding. Graphics Processing Unit (GPU) has been proposed for many years as potential accelerators in complex scientific problems, but it has not been used until the recent advances in the programmability of GPUs that the best available reconstruction codes have started to be implemented to be run on GPUs. This work presents a GPU-based fully 3D PET iterative reconstruction software. This new code may reconstruct sinogram data from several commercially available PET scanners. The most important and time-consuming parts of the code, the forward and backward projection operations, are based on an accurate model of the scanner obtained with the Monte Carlo code PeneloPET and they have been massively parallelized on the GPU. For the PET scanners considered, the GPU-based code is more than 70 times faster than a similar code running on a single core of a fast CPU, obtaining in both cases the same images. The code has been designed to be easily adapted to reconstruct sinograms from any other PET scanner, including scanner prototypes.

  9. Positron Emission Tomography (PET) in Oncology

    Energy Technology Data Exchange (ETDEWEB)

    Gallamini, Andrea, E-mail: gallamini.a@ospedale.cuneo.it [Department of Research and Medical Innovation, Antoine Lacassagne Cancer Center, Nice University, Nice Cedex 2-06189 Nice (France); Zwarthoed, Colette [Department of Nuclear Medicine, Antoine Lacassagne Cancer Center, Nice University, Nice Cedex 2-06189 Nice (France); Borra, Anna [Hematology Department S. Croce Hospital, Via M. Coppino 26, Cuneo 12100 (Italy)

    2014-09-29

    Since its introduction in the early nineties as a promising functional imaging technique in the management of neoplastic disorders, FDG-PET, and subsequently FDG-PET/CT, has become a cornerstone in several oncologic procedures such as tumor staging and restaging, treatment efficacy assessment during or after treatment end and radiotherapy planning. Moreover, the continuous technological progress of image generation and the introduction of sophisticated software to use PET scan as a biomarker paved the way to calculate new prognostic markers such as the metabolic tumor volume (MTV) and the total amount of tumor glycolysis (TLG). FDG-PET/CT proved more sensitive than contrast-enhanced CT scan in staging of several type of lymphoma or in detecting widespread tumor dissemination in several solid cancers, such as breast, lung, colon, ovary and head and neck carcinoma. As a consequence the stage of patients was upgraded, with a change of treatment in 10%–15% of them. One of the most evident advantages of FDG-PET was its ability to detect, very early during treatment, significant changes in glucose metabolism or even complete shutoff of the neoplastic cell metabolism as a surrogate of tumor chemosensitivity assessment. This could enable clinicians to detect much earlier the effectiveness of a given antineoplastic treatment, as compared to the traditional radiological detection of tumor shrinkage, which usually takes time and occurs much later.

  10. Evaluation of various hepatic lesions with PET

    International Nuclear Information System (INIS)

    When a liver lesion is found in a PET image, differential diagnosis and analysis of the lesion is very important. We tried to analyze hepatic lesions found in PET. 53 patients with focal liver lesions (13 patients with HCC, 8 patients with cholangiocarcinoma (CC), 20 patients with liver metastasis, 5 patients with hemangioma, 7 patients with liver abscess, including 1 patient with liver candidiasis) were examined. Definitely high FDG uptake pattern were observed in 54% (7/13) of HCC, 100% (8/8) of CC, 95% (19/20) of metastatic liver cancer and 100% (7/7) of liver abscess. Therefore, PET was partially useful in the diagnosis of HCC, but it was very useful in the diagnosis of CC or liver metastasis or liver abscess. The contrast between lesions and surrounding liver background was very conspicuous in PET images of CC or liver metastasis or liver abscess, which suggests that PET might be used for the follow up and assessment of treatment response of these diseases

  11. Fully 3D GPU PET reconstruction

    International Nuclear Information System (INIS)

    Fully 3D iterative tomographic image reconstruction is computationally very demanding. Graphics Processing Unit (GPU) has been proposed for many years as potential accelerators in complex scientific problems, but it has not been used until the recent advances in the programmability of GPUs that the best available reconstruction codes have started to be implemented to be run on GPUs. This work presents a GPU-based fully 3D PET iterative reconstruction software. This new code may reconstruct sinogram data from several commercially available PET scanners. The most important and time-consuming parts of the code, the forward and backward projection operations, are based on an accurate model of the scanner obtained with the Monte Carlo code PeneloPET and they have been massively parallelized on the GPU. For the PET scanners considered, the GPU-based code is more than 70 times faster than a similar code running on a single core of a fast CPU, obtaining in both cases the same images. The code has been designed to be easily adapted to reconstruct sinograms from any other PET scanner, including scanner prototypes.

  12. Positron Emission Tomography (PET in Oncology

    Directory of Open Access Journals (Sweden)

    Andrea Gallamini

    2014-09-01

    Full Text Available Since its introduction in the early nineties as a promising functional imaging technique in the management of neoplastic disorders, FDG-PET, and subsequently FDG-PET/CT, has become a cornerstone in several oncologic procedures such as tumor staging and restaging, treatment efficacy assessment during or after treatment end and radiotherapy planning. Moreover, the continuous technological progress of image generation and the introduction of sophisticated software to use PET scan as a biomarker paved the way to calculate new prognostic markers such as the metabolic tumor volume (MTV and the total amount of tumor glycolysis (TLG. FDG-PET/CT proved more sensitive than contrast-enhanced CT scan in staging of several type of lymphoma or in detecting widespread tumor dissemination in several solid cancers, such as breast, lung, colon, ovary and head and neck carcinoma. As a consequence the stage of patients was upgraded, with a change of treatment in 10%–15% of them. One of the most evident advantages of FDG-PET was its ability to detect, very early during treatment, significant changes in glucose metabolism or even complete shutoff of the neoplastic cell metabolism as a surrogate of tumor chemosensitivity assessment. This could enable clinicians to detect much earlier the effectiveness of a given antineoplastic treatment, as compared to the traditional radiological detection of tumor shrinkage, which usually takes time and occurs much later.

  13. [Microbiological conservation medicine and exotic pets].

    Science.gov (United States)

    Hassl, Andreas

    2004-01-01

    The keeping and the breeding of exotic pets in privacy is a hobby with increasing popularity in industrialised countries. The growing demand for animals usually imported from the tropics, the growing demand for unprofessionally bred feeder organisms, and the increasing number of cases of faulty caring behaviour lead to the creation of new infectiological niches in the interface between exotic pet--nurse--feed--vivarium. These niches are filled preferably by ubiquitous, facultative pathogenic, stress- and age-deduced opportunists with a broad host spectrum. On the one hand these extraordinary germ faunas, relating to their compositions, may generate broad relevance in human medicine, lead to bizarre clinical pictures in specific cases, and may contribute to a reduction of the mean span of life of exotic pets kept in human care. On the other hand the quantitative composition of the fauna may also be a direct measure of the degree of stress the pets are suffering in captivity. Thus, a professional designation of the germ fauna of an exotic pet may contribute to an optimisation of the captivity conditions. PMID:15683044

  14. Evaluation of various hepatic lesions with PET

    Energy Technology Data Exchange (ETDEWEB)

    Han, Chul Ju

    2000-12-01

    When a liver lesion is found in a PET image, differential diagnosis and analysis of the lesion is very important. We tried to analyze hepatic lesions found in PET. 53 patients with focal liver lesions (13 patients with HCC, 8 patients with cholangiocarcinoma (CC), 20 patients with liver metastasis, 5 patients with hemangioma, 7 patients with liver abscess, including 1 patient with liver candidiasis) were examined. Definitely high FDG uptake pattern were observed in 54% (7/13) of HCC, 100% (8/8) of CC, 95% (19/20) of metastatic liver cancer and 100% (7/7) of liver abscess. Therefore, PET was partially useful in the diagnosis of HCC, but it was very useful in the diagnosis of CC or liver metastasis or liver abscess. The contrast between lesions and surrounding liver background was very conspicuous in PET images of CC or liver metastasis or liver abscess, which suggests that PET might be used for the follow up and assessment of treatment response of these diseases.

  15. Know the Risks of Feeding Raw Food to Your Pets

    Science.gov (United States)

    ... causing bacteria. Two of these bacteria— Salmonella and Listeria monocytogenes — are particularly dangerous to both pets and humans. ... poultry to kill harmful bacteria like Salmonella and Listeria monocytogenes before you give the food to your pets. ...

  16. PET imaging in pediatric neuroradiology: current and future applications

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Sunhee [Children' s Hospital of Pittsburgh of UPMC, Department of Radiology, Pittsburgh, PA (United States); Salamon, Noriko [UCLA David Geffen School of Medicine at UCLA, Department of Radiology, Ronald Reagan UCLA Medical Center, Los Angeles, CA (United States); Jackson, Hollie A.; Blueml, Stefan [Keck School of Medicine of USC, Department of Radiology, Childrens Hospital Los Angeles, Los Angeles, CA (United States); Panigrahy, Ashok [Children' s Hospital of Pittsburgh of UPMC, Department of Radiology, Pittsburgh, PA (United States); Keck School of Medicine of USC, Department of Radiology, Childrens Hospital Los Angeles, Los Angeles, CA (United States)

    2010-01-15

    Molecular imaging with positron emitting tomography (PET) is widely accepted as an essential part of the diagnosis and evaluation of neoplastic and non-neoplastic disease processes. PET has expanded its role from the research domain into clinical application for oncology, cardiology and neuropsychiatry. More recently, PET is being used as a clinical molecular imaging tool in pediatric neuroimaging. PET is considered an accurate and noninvasive method to study brain activity and to understand pediatric neurological disease processes. In this review, specific examples of the clinical use of PET are given with respect to pediatric neuroimaging. The current use of co-registration of PET with MR imaging is exemplified in regard to pediatric epilepsy. The current use of PET/CT in the evaluation of head and neck lymphoma and pediatric brain tumors is also reviewed. Emerging technologies including PET/MRI and neuroreceptor imaging are discussed. (orig.)

  17. [¹⁸F]-fluorodeoxyglucose PET imaging of atherosclerosis

    DEFF Research Database (Denmark)

    Blomberg, Björn Alexander; Høilund-Carlsen, Poul Flemming

    2015-01-01

    [(18)F]-fluorodeoxyglucose PET ((18)FDG PET) imaging has emerged as a promising tool for assessment of atherosclerosis. By targeting atherosclerotic plaque glycolysis, a marker for plaque inflammation and hypoxia, (18)FDG PET can assess plaque vulnerability and potentially predict risk of atheros......[(18)F]-fluorodeoxyglucose PET ((18)FDG PET) imaging has emerged as a promising tool for assessment of atherosclerosis. By targeting atherosclerotic plaque glycolysis, a marker for plaque inflammation and hypoxia, (18)FDG PET can assess plaque vulnerability and potentially predict risk...... of atherosclerosis-related disease, such as stroke and myocardial infarction. With excellent reproducibility, (18)FDG PET can be a surrogate end point in clinical drug trials, improving trial efficiency. This article summarizes key findings in the literature, discusses limitations of (18)FDG PET imaging...... of atherosclerosis, and reports recommendations to optimize imaging protocols....

  18. FLOODPLAIN, AUSTIN COUNTY, TEXAS

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — The Floodplain Mapping/Redelineation study deliverables depict and quantify the flood risks for the study area. The primary risk classificatinos used are the...

  19. Scavenger hunt in the CERN Computing Centre

    CERN Multimedia

    CERN Bulletin

    2013-01-01

    Hidden among the racks of servers and disks in the CERN Computing Centre, you’ll find Hawaiian dancers, space aliens, gorillas… all LEGO® figurines! These characters were placed about the Centre for the arrival of Google’s Street View team for the world to discover.   PLEASE NOTE THAT THE COMPETITION IS OVER. ONLY FOR REFERENCE, HERE IS THE ORIGINAL ARTICLE. We’re pleased to announce our first global scavenger hunt! Spot three LEGO® figurines using Google’s Street View and you’ll be entered to win a gift of your choice from our CERN Gift Guide. A LEGO® figurine in the CERN Computing Centre, as seen on Google Street View. Here are the details: Find at least three LEGO® figurines hidden around the CERN Computing Centre using Google Street View.   Take screencaps of the figurines and e-mail the pictures to TreasureHunt-ComputingCentre@cern.ch. This email is no longer active.   The...

  20. Visits to Tier-1 Computing Centres

    CERN Multimedia

    Dario Barberis

    At the beginning of 2007 it became clear that an enhanced level of communication is needed between the ATLAS computing organisation and the Tier-1 centres. Most usual meetings are ATLAS-centric and cannot address the issues of each Tier-1; therefore we decided to organise a series of visits to the Tier-1 centres and focus on site issues. For us, ATLAS computing management, it is most useful to realize how each Tier-1 centre is organised, and its relation to the associated Tier-2s; indeed their presence at these visits is also very useful. We hope it is also useful for sites... at least, we are told so! The usual participation includes, from the ATLAS side: computing management, operations, data placement, resources, accounting and database deployment coordinators; and from the Tier-1 side: computer centre management, system managers, Grid infrastructure people, network, storage and database experts, local ATLAS liaison people and representatives of the associated Tier-2s. Visiting Tier-1 centres (1-4). ...

  1. Malignancy rate of biopsied suspicious bone lesions identified on FDG PET/CT

    Energy Technology Data Exchange (ETDEWEB)

    Adams, Hugo J.A.; Kwee, Thomas C. [University Medical Center Utrecht, Department of Radiology and Nuclear Medicine, Utrecht (Netherlands); Klerk, John M.H. de [Meander Medical Center, Department of Nuclear Medicine, Amersfoort (Netherlands); Heggelman, Ben G.F. [Meander Medical Center, Department of Radiology, Amersfoort (Netherlands); Dubois, Stefan V. [Meander Medical Center, Department of Pathology, Amersfoort (Netherlands)

    2016-07-15

    To determine the malignancy rate of bone lesions identified on FDG PET/CT in patients who have undergone CT-guided biopsy because of the suspicion of malignancy. This single-centre retrospective study spanned eight consecutive years and included all patients who underwent both FDG PET/CT and CT-guided bone biopsy because of the suspicion of malignancy. The positive predictive value (PPV) for malignancy was calculated, and different patient and imaging characteristics were compared between malignant and benign bone lesions. Of 102 included patients with bone lesions that all showed FDG uptake exceeding mediastinal uptake, bone biopsy showed a malignant lesion in 91 patients, yielding a PPV for malignancy of 89.2 % (95 % CI 81.7 - 93.9 %). In the 94 patients with bone lesions that showed FDG uptake exceeding liver uptake, bone biopsy showed a malignant lesion in 83 patients, yielding a PPV for malignancy of 88.3 % (95 % CI 80.1 - 93.5 %). Higher age, bone marrow replacement of the lesion seen on CT, expansion of the lesion seen on CT, and presence of multifocal lesions on FDG PET/CT were significantly more frequent in patients with malignant lesions than in those with benign bone lesions (P = 0.044, P = 0.009, P = 0.015, and P = 0.019, respectively). Furthermore, there was a trend towards a higher incidence of cortical destruction (P = 0.056) and surrounding soft tissue mass (P = 0.063) in patients with malignant bone lesions. The PPV for malignancy of suspicious bone lesions identified on FDG PET/CT is not sufficiently high to justify changes in patient management without histopathological confirmation. Nevertheless, ancillary patient and imaging characteristics may increase the likelihood of a malignant bone lesion. (orig.)

  2. Breast cancer detection using high-resolution breast PET compared to whole-body PET or PET/CT

    Energy Technology Data Exchange (ETDEWEB)

    Kalinyak, Judith E. [Naviscan Inc., San Diego, CA (United States); Berg, Wendie A. [University of Pittsburgh School of Medicine, Magee-Womens Hospital, Pittsburgh, PA (United States); Schilling, Kathy [Boca Raton Regional Hospital, Boca Raton, FL (United States); Madsen, Kathleen S. [Certus International, Inc., St. Louis, MO (United States); Narayanan, Deepa [Naviscan Inc., San Diego, CA (United States); National Cancer Institute, Bethesda, MD (United States); Tartar, Marie [Scripps Clinic, Scripps Green Hospital, La Jolla, CA (United States)

    2014-02-15

    To compare the performance characteristics of positron emission mammography (PEM) with those of whole-body PET (WBPET) and PET/CT in women with newly diagnosed breast cancer. A total of 178 women consented to PEM for presurgical planning in an IRB-approved protocol and also underwent either WBPET (n = 69) or PET/CT (n = 109) imaging, as per usual care at three centers. Tumor detection sensitivity, positive predictive values, and {sup 18}F-fluorodeoxyglucose (FDG) uptake were compared between the modalities. The effects of tumor size, type, and grade on detection were examined. The chi-squared or Fisher's exact tests were used to compare distributions between groups, and McNemar's test was used to compare distributions for paired data within subject groups, i.e. PEM versus WBPET or PEM versus PET/CT. The mean age of the women was 59 ± 12 years (median 60 years, range 26-89 years), with a mean invasive index tumor size of 1.6 ± 0.8 cm (median 1.5 cm, range 0.5-4.0 cm). PEM detected more index tumors (61/66, 92 %) than WBPET (37/66, 56 %; p < 0.001) or PET/CT (95/109, 87 % vs. 104/109, 95 % for PEM; p < 0.029). Sensitivity for the detection of additional ipsilateral malignancies was also greater with PEM (7/15, 47 %) than with WBPET (1/15, 6.7 %; p = 0.014) or PET/CT (3/23, 13 % vs. 13/23, 57 % for PEM; p = 0.003). Index tumor detection decreased with decreasing invasive tumor size for both WBPET (p = 0.002) and PET/CT (p < 0.001); PEM was not significantly affected (p = 0.20). FDG uptake, quantified in terms of maximum PEM uptake value, was lowest in ductal carcinoma in situ (median 1.5, range 0.7-3.0) and invasive lobular carcinoma (median 1.5, range 0.7-3.4), and highest in grade III invasive ductal carcinoma (median 3.1, range 1.4-12.9). PEM was more sensitive than either WBPET or PET/CT in showing index and additional ipsilateral breast tumors and remained highly sensitive for tumors smaller than 1 cm. (orig.)

  3. 浅析“PET/CT检查”%PET/CT Examinations

    Institute of Scientific and Technical Information of China (English)

    李燕; 邵建霞; 田蕴青

    2014-01-01

    PET/CT examinations are general inspections, which utilize different imaging principle to obtain cross-sectional and functional fusion images of the whole body by only one examination. As an important method for diagnosing early stage tumor, PET/CT examinations have some limitations such as poor specificity of smal tumor, false-positive, false-negative, image artifacts, large radiation dosage, and expensive price. However, PET/CT would overcome these limitations and be used more widely due to the continuous development of new technology of PET and CT.%PET/CT检查是一种全身性检查手段,其利用了PET和CT两种不同成像原理的设备,一次检查即可获取全身各方位的断层功能融合图像。 PET/CT检查已成为诊断早期肿瘤非常重要的检查手段,尽管其存在对小肿瘤特异性差、假阳性和假阴性、图像有伪影、辐射剂量大、价格昂贵等局限性,但在PET、CT等新技术的不断发展下,PET/CT将克服这些局限性得到更加广泛的应用。

  4. Combined PET-MRI of the abdomen; Kombinierte PET-MRT des Abdomens

    Energy Technology Data Exchange (ETDEWEB)

    Vag, Tibor; Eiber, M.; Schwaiger, M. [Technische Universitaet Muenchen, Klinik fuer Nuklearmedizin, Klinikum Rechts der Isar, Muenchen (Germany)

    2015-12-15

    The first fully integrated combined positron emission tomography-magnetic resonance imaging (PET-MRI) scanners have been clinically available since 2010. Large prospective studies regarding indications and diagnostic accuracy of this new modality are not yet available; however, preliminary studies have shown a higher diagnostic accuracy and confidence compared to PET-computed tomography (PET-CT) in regions where MRI is known to be superior to CT, such as the liver. The benefit of MRI in accurate lesion characterization and the additional value of diffusion-weighted imaging (DWI) as a complementary functional modality by means of the apparent diffusion coefficient (ADC) is apparent in entities with low tracer uptake (e. g. due to small size) and a decreased or absent accumulation pattern on PET. (orig.) [German] Seit 2010 sind die ersten voll integrierten Positronenemissionstomographie(PET)-MR-Scanner im klinischen Gebrauch. Obwohl es derzeit noch an empirischen Daten im Sinne groesserer und prospektiver Studien fehlt, implizieren erste Studien einen diagnostischen Mehrwert gegenueber der PET-CT in Regionen, in denen die MRT bekanntermassen der CT ueberlegen ist. Diese ist in der besseren morphologischen Charakterisierung begruendet, die insbesondere bei Laesionen mit geringer Tracerspeicherung (z. B. aufgrund der geringen Groesse) oder unbekanntem Speicherverhalten in der PET ausschlaggebend ist. Zudem steht der MRT eine komplementaere funktionelle Modalitaet in Form der Diffusionsbildgebung zur Verfuegung, die ueber die Berechnung des Apparent-diffusion-coefficient(ADC)-Werts eine weitere Einschaetzung des Gewebes geben kann. (orig.)

  5. The Aube centre. 1997 statement; Le centre de l`Aube. Bilan 1997

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-09-01

    Since January 1992 the Aube centre ensures the storage of 90% of the short life radioactive wastes produced in France. This educational booklet describes the organization of the activities in the centre from the storage of wastes to the radioactivity surveillance of the environment (air, surface and ground waters, river sediments, plants and milk). (J.S.)

  6. Cine CT for Attenuation Correction in Cardiac PET/CT

    OpenAIRE

    Alessio, Adam M.; Kohlmyer, Steve; Branch, Kelley; Chen, Grace; Caldwell, James; Kinahan, Paul

    2007-01-01

    In dual-modality PET/CT systems, the CT scan provides the attenuation map for PET attenuation correction. The current clinical practice of obtaining a single helical CT scan provides only a snapshot of the respiratory cycle, whereas PET occurs over multiple respiratory cycles. Misalignment of the attenuation map and emission image because of respiratory motion causes errors in the attenuation correction factors and artifacts in the attenuation-corrected PET image. To rectify this problem, we ...

  7. PET-CT in oncology: making the most of CT

    OpenAIRE

    Miles, K. A.

    2008-01-01

    Abstract Combined positron emission tomography–computed tomography (PET-CT) has made a significant impact on cancer imaging. The use of CT to map tissue attenuation for correction of PET images and the ability to co-register the functional information provided by PET with the anatomical data afforded by CT, has resulted in demonstrable improvements in diagnostic accuracy. However, attenuation correction and anatomical localisation may not represent the full benefits of integrating CT with PET...

  8. Clinical oncologic applications of PET/MRI: a new horizon

    OpenAIRE

    Partovi, Sasan; Kohan, Andres; Rubbert, Christian; Vercher-Conejero, Jose Luis; Gaeta, Chiara; Yuh, Roger; Zipp, Lisa; Herrmann, Karin A.; Robbin, Mark R.; Lee, Zhenghong; Muzic, Raymond F.; Faulhaber, Peter; Ros, Pablo R

    2014-01-01

    Positron emission tomography/magnetic resonance imaging (PET/MRI) leverages the high soft-tissue contrast and the functional sequences of MR with the molecular information of PET in one single, hybrid imaging technology. This technology, which was recently introduced into the clinical arena in a few medical centers worldwide, provides information about tumor biology and microenvironment. Studies on indirect PET/MRI (use of positron emission tomography/computed tomography (PET/CT) images softw...

  9. The Power of Pets: How Animals Affect Family Relationships

    OpenAIRE

    Geller, Krista Scott

    2002-01-01

    THE POWER OF PETS: HOW ANIMALS AFFECT FAMILY RELATIONSHIPS By Krista Scott Geller Katherine R. Allen, Committee Chair Department of Human Development Virginia polytechnic Institute and State University (ABSTRACT) This study was designed to explore the importance a pet can have on someoneâ s life, including ways a pet affects the relationships an individual has with other family members. This study assessed how pets can be influential in peopleâ s lives, espe...

  10. Learning Styles of Independent Learning Centre Users

    Directory of Open Access Journals (Sweden)

    Tarik Uzun

    2014-09-01

    Full Text Available Learning style research has been a significant field within language teaching and learning. There have been very few attempts, however, to seek possible links between independent learning and learning style preferences. This paper aims to identify the learning styles of students who use the Independent Learning Centre (ILC on a regular basis at a state university in Turkey (n=102. The findings of the learning style analysis revealed that, contrary to expectations, most of the regular users of the centre were synoptic learners, which implies that these learners might not necessarily have conscious control over their own learning processes. An in-depth analysis of learning styles and recommendations to improve the services offered in the centre are also included in the paper.

  11. Occupational deprivation in an asylum centre:

    DEFF Research Database (Denmark)

    Morville, Anne-Le; Erlandsson, Lena-Karin

    2013-01-01

    This article presents a study of three asylum-seeking men from Iran and Afghanistan. It aimed to explore how and if they experienced occupations as occupations in a Danish asylum centre and how their life experience shaped their choice and value of current occupations. In-depth narrative interviews...... explored the participants’ occupational history and its influence on their occupations in the asylum centre. A thematic analysis showed that the participants had been subjected to occupational disruption and deprivation by politically oppressive systems even before their flight. Their occupations...... in Denmark were to a certain extent influenced by their earlier occupations and the current occupational deprivation they all experienced was due to limited possibilities in the centre. Although they tried their best to fill their days and create structure, there was a loss of valued occupations...

  12. A day in the CERN Control Centre

    CERN Multimedia

    Rosaria Marraffino

    2015-01-01

    The CERN Control Centre (CCC) is the nerve centre of the CERN beam systems. From this room, the experts prepare, monitor, adjust, and control the particle beams that circulate throughout the accelerator complex while ensuring that the services and the technical infrastructure work flawlessly. Buttons, screens, telephones, lights (but no sound): in the CCC, everything is ready to make it possible for the LHC to reach the unprecedented energies expected at Run 2.   Seen from above, the CERN Control Centre resembles the shape of a quadrupole magnet. The consoles are distributed in four circles, called “islands”, dedicated to the LHC, the SPS, the PS Complex and the Technical Infrastructure (TI) respectively. Spread between TI and LHC are the Cryogenics consoles. Being in the same room allows the 24h-manned islands to be constantly in touch with one another, thus ensuring the best performance of the machines. At the LHC island, operators are currently busy training the magnet...

  13. Wildlife, exotic pets, and emerging zoonoses.

    Science.gov (United States)

    Chomel, Bruno B; Belotto, Albino; Meslin, François-Xavier

    2007-01-01

    Most emerging infectious diseases are zoonotic; wildlife constitutes a large and often unknown reservoir. Wildlife can also be a source for reemergence of previously controlled zoonoses. Although the discovery of such zoonoses is often related to better diagnostic tools, the leading causes of their emergence are human behavior and modifications to natural habitats (expansion of human populations and their encroachment on wildlife habitat), changes in agricultural practices, and globalization of trade. However, other factors include wildlife trade and translocation, live animal and bushmeat markets, consumption of exotic foods, development of ecotourism, access to petting zoos, and ownership of exotic pets. To reduce risk for emerging zoonoses, the public should be educated about the risks associated with wildlife, bushmeat, and exotic pet trades; and proper surveillance systems should be implemented.

  14. Cardiac sympathetic neuronal imaging using PET

    Energy Technology Data Exchange (ETDEWEB)

    Lautamaeki, Riikka; Tipre, Dnyanesh [Johns Hopkins University, Division of Nuclear Medicine, Russell H. Morgan Department of Radiology and Radiological Science, Baltimore, MD (United States); Bengel, Frank M. [Johns Hopkins University, Division of Nuclear Medicine, Russell H. Morgan Department of Radiology and Radiological Science, Baltimore, MD (United States); Cardiovascular Nuclear Medicine, Baltimore, MD (United States)

    2007-06-15

    Balance of the autonomic nervous system is essential for adequate cardiac performance, and alterations seem to play a key role in the development and progression of various cardiac diseases. PET imaging of the cardiac autonomic nervous system has advanced extensively in recent years, and multiple pre- and postsynaptic tracers have been introduced. The high spatial and temporal resolution of PET enables noninvasive quantification of neurophysiologic processes at the tissue level. Ligands for catecholamine receptors, along with radiolabeled catecholamines and catecholamine analogs, have been applied to determine involvement of sympathetic dysinnervation at different stages of heart diseases such as ischemia, heart failure, and arrhythmia. This review summarizes the recent findings in neurocardiological PET imaging. Experimental studies with several radioligands and clinical findings in cardiac dysautonomias are discussed. (orig.)

  15. Technology challenges in small animal PET imaging

    Energy Technology Data Exchange (ETDEWEB)

    Lecomte, Roger E-mail: roger.lecomte@usherbrooke.ca

    2004-07-11

    Positron Emission Tomography (PET) is a non-invasive nuclear imaging modality allowing biochemical processes to be investigated in vivo with sensitivity in the picomolar range. For this reason, PET has the potential to play a major role in the emerging field of molecular imaging by enabling the study of molecular pathways and genetic processes in living animals non-invasively. The challenge is to obtain a spatial resolution that is appropriate for rat and mouse imaging, the preferred animal models for research in biology, while achieving a sensitivity adequate for real-time measurement of rapid dynamic processes in vivo without violating tracer kinetic principles. An overview of the current state of development of dedicated small animal PET scanners is given, and selected applications are reported and discussed with respect to performance and significance to research in biology.

  16. PET designated flouride-18 production and chemistry.

    Science.gov (United States)

    Jacobson, Orit; Chen, Xiaoyuan

    2010-01-01

    Positron emission tomography (PET) is a nuclear medicine imaging technology which allows for four-dimensional, quantitative determination of the distribution of labeled biological compounds within the human body. PET is becoming an increasingly important tool for the measurement of physiological, biochemical and pharmacological functions at the molecular level in healthy and pathological conditions. This review will focus on Flouride-18, one of the common isotopes used for PET imaging, which has a half life of 109.8 minutes. This isotope can be produced with an efficient yield in a cyclotron as a nucleophile or as an electrophile. Flouride-18 can be thereafter introduced into small molecules or biomolecules using various chemical synthetic routes, to give the desired imaging agent.

  17. Automated radiochemical processing for clinical PET

    International Nuclear Information System (INIS)

    The Siemens RDS 112, an automated radiochemical production and delivery system designed to support a clinical PET program, consists of an 11 MeV, proton only, negative ion cyclotron, a shield, a computer, and targetry and chemical processing modules to produce radiochemicals used in PET imaging. The principal clinical PET tracers are [18F]FDG, [13N]ammonia and [15O]water. Automated synthesis of [18F]FDG is achieved using the Chemistry Process Control Unit (CPCU), a general purpose valve-and-tubing device that emulates manual processes while allowing for competent operator intervention. Using function-based command file software, this pressure-driven synthesis system carries out chemical processing procedures by timing only, without process-based feedback. To date, nine CPCUs have installed at seven institutions resulting in 1,200+ syntheses of [18F]FDG, with an average yield of 55% (EOB)

  18. Functional diagnosis of cancer using PET

    International Nuclear Information System (INIS)

    Positron emission tomography (PET) can demonstrate increased metabolic demand as visual images, and it provides alternative information for diagnosis that can be used to complement morphological observations. This year, we carried out a study on the usefulness of methionine PET for diagnosis in ovarian cancer. In this study, 13 cases with ovarian tumor, 9 cases were original or recurrent malignant tumors and 4 cases were benign tumors, were studied by both C-11 methionine and FDG PET. All cases received the two PET studies at intervals of one week. C-11 methionine PET showed mean accumulation of 5.26±0.68 (tumor-to-muscle ratio (TMR)) in malignant group and 2.56±0.40 (TMR) in benign group which were significantly different by p-value=0.030. FDG PET showed mean accumulation of 5.80±1.24 standardized uptake value (SUV)) in malignant group and 2.44±0.40 (SUV) in benign group which were significantly different by p-value=0.029. We compared the diagnostic accuracy with C-11 methionine, FDG PET, X-ray CT and CA125 serum level. In C-11 methionine and FDG PET studies, sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) were 88.9%, 75.0%, 88.9% and 75.0%, respectively. C-11 methionine and FDG-PET showed just the same diagnostic accuracy in our cases. In X-ray CT study, sensitivity, specificity, PPV and NPV were 55.6%, 75.0%, 83.3% and 42.9%, respectively. The tumor marker, CA125 level in the serum, showed that sensitivity, specificity, PPV and NPV were 55.6%, 25.0%, 62.5% and 20.0%, respectively. C-11 methionine PET was superior in diagnostic accuracy to usual diagnostic tools such as X-ray CT findings and CA125 serum level, and it had same diagnostic accuracy with FDG PET. C-11 methionine accumulated in normal liver and normal intestine physiologically, some cases showed that FDG was able to detect lesions in these organs better than C-11 methionine. But FDG accumulated in very high level in urinal system form kidney to bladder

  19. Positron kinetics in an idealized PET environment

    Science.gov (United States)

    Robson, R. E.; Brunger, M. J.; Buckman, S. J.; Garcia, G.; Petrović, Z. Lj.; White, R. D.

    2015-08-01

    The kinetic theory of non-relativistic positrons in an idealized positron emission tomography PET environment is developed by solving the Boltzmann equation, allowing for coherent and incoherent elastic, inelastic, ionizing and annihilating collisions through positronium formation. An analytic expression is obtained for the positronium formation rate, as a function of distance from a spherical source, in terms of the solutions of the general kinetic eigenvalue problem. Numerical estimates of the positron range - a fundamental limitation on the accuracy of PET, are given for positrons in a model of liquid water, a surrogate for human tissue. Comparisons are made with the ‘gas-phase’ assumption used in current models in which coherent scattering is suppressed. Our results show that this assumption leads to an error of the order of a factor of approximately 2, emphasizing the need to accurately account for the structure of the medium in PET simulations.

  20. Pet Care Teaching Unit: 1st-3rd Grades.

    Science.gov (United States)

    Peninsula Humane Society, San Mateo, CA.

    Activities in this unit are designed to familiarize primary grade students with the responsibilities involved in pet ownership. Teaching plans are provided for a total of 12 lessons involving social studies, language arts, math, and health sciences. Activities adaptable for readers and non-readers focus on pet overpopulation, care of pets when…

  1. 24 CFR 5.318 - Discretionary pet rules.

    Science.gov (United States)

    2010-04-01

    ... supportive services or supervision (other than continual nursing, medical or psychiatric care). (ii) For... nursing, medical or psychiatric care). (c) Pet size and pet type. The pet rules may place reasonable... Total Tenant Payment (as defined in 24 CFR 913.102) or such reasonable fixed amount as the PHA...

  2. 50 CFR 36.36 - Sled dogs and household pets.

    Science.gov (United States)

    2010-10-01

    ... Sled dogs and household pets. The general trespass provisions of 50 CFR 26.21 shall not apply to household pets and sled, work, or pack dogs under the direct control of their owners or handlers, but such... 50 Wildlife and Fisheries 6 2010-10-01 2010-10-01 false Sled dogs and household pets....

  3. Ictal PET in presurgical workup of refractory extratemporal epilepsy

    Directory of Open Access Journals (Sweden)

    Javeria Nooraine

    2013-01-01

    Full Text Available Ictal Pet in presurgical workup of refractory epilepsy is seldom performed and limited due to technical difficulties. In carefully selected patient subset with frequent extratemporal seizures, ictal PET depicts ′seizure onset zone′ with high spatial resolution even within a widespread pathology. We here depict a four year old with posterior quadrant dysplasia evaluated with ictal PET.

  4. Couples' Perception of Stressfulness of Death of the Family Pet.

    Science.gov (United States)

    Gage, M. Geraldine; Holcomb, Ralph

    1991-01-01

    Surveyed 242 couples whose pet had died during 3 years prior to survey. About one-half of wives and over one-quarter of husbands reported being "quite" or "extremely" disturbed by pet death. Husbands rated pet loss about as stressful as loss of close friendship; wives rated it about as stressful as losing touch with married children. (Author/NB)

  5. 76 FR 8770 - Polyethylene Terephthalate (Pet) Film From Korea

    Science.gov (United States)

    2011-02-15

    ... COMMISSION Polyethylene Terephthalate (Pet) Film From Korea AGENCY: United States International Trade... full five-year review concerning the antidumping duty order on polyethylene terephthalate (PET) film... whether revocation of the antidumping order on PET film from Korea would be likely to lead to...

  6. 75 FR 53711 - Polyethylene Terephthalate (PET) Film From Korea

    Science.gov (United States)

    2010-09-01

    ... Department of Commerce (Commerce) issued an antidumping duty order on imports of PET film from Korea (56 FR..., Commerce issued a continuation of the antidumping duty order on imports of PET film from Korea (65 FR 11984... issued a continuation of the antidumping duty order on imports of PET film from Korea (70 FR 61118)....

  7. SPECT and PET imaging in epilepsia; SPECT und PET in der Diagnostik von Epilepsien

    Energy Technology Data Exchange (ETDEWEB)

    Landvogt, C. [Mainz Univ. (Germany). Klinik und Poliklinik fuer Nuklearmedizin

    2007-09-15

    In preoperative localisation of epileptogenic foci, nuclear medicine diagnostics plays a crucial role. FDG-PET is used as first line diagnostics. In case of inconsistent MRI, EEG and FDG-PET findings, {sup 11}C-Flumazenil-PET or ictal and interictal perfusion-SPECT should be performed. Other than FDG, Flumazenil can help to identify the extend of the region, which should be resected. To enhance sensitivity and specificity, further data analysis using voxelbased statistical analyses or SISCOM (substraction ictal SPECT coregistered MRI) should be performed.

  8. Choline PET and PET/CT in Primary Diagnosis and Staging of Prostate Cancer

    Directory of Open Access Journals (Sweden)

    S. Schwarzenböck, M. Souvatzoglou, B. J. Krause

    2012-01-01

    Full Text Available PET and PET/CT using [11C]- and [18F]-labelled choline derivates is increasingly being used for imaging of primary and recurrent prostate cancer. While PET and PET/CT with [11C]- and [18F]-labelled choline derivates in patients suffering from biochemical recurrence of prostate cancer has been examined in many studies that demonstrate an increasing importance, its role in the primary staging of prostate cancer is still a matter of debate.Morphological and functional imaging techniques such as CT, MRI and TRUS have demonstrated only limited accuracy for the diagnosis of primary prostate cancer. Molecular imaging with PET and PET/CT could potentially increase accuracy to localize primary prostate cancer. A considerable number of studies have examined the value of PET/CT with [11C]- and [18F]- labelled choline derivates for the diagnosis of primary prostate cancer with mixed results. Primary prostate cancer can only be detected with moderate sensitivity using [11C]- and [18F]choline PET and PET/CT. The detection rate depends on the tumour configuration. Detection is also limited by a considerable number of microcarcinomas that cannot be detected due to partial volume effects. Therefore small and in part rind-like tumours can often not be visualized. Furthermore, the differentiation between benign changes like prostatitis, high-grade intraepithelial neoplasia (HGPIN or prostatic hyperplasia is not always possible. Therefore, at the present time, the routine use of PET/CT with [11C]- and [18F]-labelled choline derivates cannot be recommended as a first-line screening procedure for primary prostate cancer in men at risk. A potential application of choline PET and PET/CT may be to increase the detection rate of clinically suspected prostate cancer with multiple negative prostate biopsies, for example in preparation of a focused re-biopsy and may play a role in patient stratification with respect to primary surgery and radiation therapy in the future.

  9. Head and neck imaging with PET and PET/CT: artefacts from dental metallic implants

    International Nuclear Information System (INIS)

    Germanium-68 based attenuation correction (PETGe68) is performed in positron emission tomography (PET) imaging for quantitative measurements. With the recent introduction of combined in-line PET/CT scanners, CT data can be used for attenuation correction. Since dental implants can cause artefacts in CT images, CT-based attenuation correction (PETCT) may induce artefacts in PET images. The purpose of this study was to evaluate the influence of dental metallic artwork on the quality of PET images by comparing non-corrected images and images attenuation corrected by PETGe68 and PETCT. Imaging was performed on a novel in-line PET/CT system using a 40-mAs scan for PETCT in 41 consecutive patients with high suspicion of malignant or inflammatory disease. In 17 patients, additional PETGe68 images were acquired in the same imaging session. Visual analysis of fluorine-18 fluorodeoxyglucose (FDG) distribution in several regions of the head and neck was scored on a 4-point scale in comparison with normal grey matter of the brain in the corresponding PET images. In addition, artefacts adjacent to dental metallic artwork were evaluated. A significant difference in image quality scoring was found only for the lips and the tip of the nose, which appeared darker on non-corrected than on corrected PET images. In 33 patients, artefacts were seen on CT, and in 28 of these patients, artefacts were also seen on PET imaging. In eight patients without implants, artefacts were seen neither on CT nor on PET images. Direct comparison of PETGe68 and PETCT images showed a different appearance of artefacts in 3 of 17 patients. Malignant lesions were equally well visible using both transmission correction methods. Dental implants, non-removable bridgework etc. can cause artefacts in attenuation-corrected images using either a conventional 68Ge transmission source or the CT scan obtained with a combined PET/CT camera. We recommend that the non-attenuation-corrected PET images also be evaluated

  10. Clinical Utility and Future Applications of PET/CT and PET/CMR in Cardiology.

    Science.gov (United States)

    Pan, Jonathan A; Salerno, Michael

    2016-01-01

    Over the past several years, there have been major advances in cardiovascular positron emission tomography (PET) in combination with either computed tomography (CT) or, more recently, cardiovascular magnetic resonance (CMR). These multi-modality approaches have significant potential to leverage the strengths of each modality to improve the characterization of a variety of cardiovascular diseases and to predict clinical outcomes. This review will discuss current developments and potential future uses of PET/CT and PET/CMR for cardiovascular applications, which promise to add significant incremental benefits to the data provided by each modality alone. PMID:27598207

  11. PRODUCTION CONSIDERATIONS FOR THE CLASSICAL PET NUCLIDES

    International Nuclear Information System (INIS)

    Nuclear Medicine is the specialty of medical imaging, which utilizes a variety of radionuclides incorporated into specific compounds for diagnostic imaging and therapeutic applications. During recent years, research efforts associated with this discipline have concentrated on the decay characteristics of particular radionuclides and the design of unique radiolabeled tracers necessary to achieve time-dependent molecular images. The specialty is expanding with specific Positron emission tomography (PET) and SPECT radiopharmaceuticals allowing for an extension from functional process imaging in tissue to pathologic processes and nuclide directed treatments. PET is an example of a technique that has been shown to yield the physiologic information necessary for clinical oncology diagnoses based upon altered tissue metabolism. Most PET drugs are currently produced using a cyclotron at locations that are in close proximity to the hospital or academic center at which the radiopharmaceutical will be administered. In November 1997, a law was enacted called the Food and Drug Administration Modernization Act of 1997 which directed the Food and Drug Administration (FDA) to establish appropriate procedures for the approval of PET drugs in accordance with section 505 of the Federal Food, Drug, and Cosmetic Act and to establish current good manufacturing practice requirements for such drugs. At this time the FDA is considering adopting special approval procedures and cGMP requirements for PET drugs. The evolution of PET radiopharmaceuticals has introduced a new class of ''drugs'' requiring production facilities and product formulations that must be closely aligned with the scheduled clinical utilization. The production of the radionuclide in the appropriate synthetic form is but one critical component in the manufacture of the finished radiopharmaceutical

  12. PET Imaging in Huntington’s Disease

    Science.gov (United States)

    Roussakis, Andreas-Antonios; Piccini, Paola

    2015-01-01

    To date, little is known about how neurodegeneration and neuroinflammation propagate in Huntington’s disease (HD). Unfortunately, no treatment is available to cure or reverse the progressive decline of function caused by the disease, thus considering HD a fatal disease. Mutation gene carriers typically remain asymptomatic for many years although alterations in the basal ganglia and cortex occur early on in mutant HD gene–carriers. Positron Emission Tomography (PET) is a functional imaging technique of nuclear medicine which enables in vivo visualization of numerous biological molecules expressed in several human tissues. Brain PET is most powerful to study in vivo neuronal and glial cells function as well as cerebral blood flow in a plethora of neurodegenerative disorders including Parkinson’s disease, Alzheimer’s and HD. In absence of HD–specific biomarkers for monitoring disease progression, previous PET studies in HD were merely focused on the study of dopaminergic terminals, cerebral blood flow and glucose metabolism in manifest and premanifest HD–gene carriers. More recently, research interest has been exploring novel PET targets in HD including the state of phosphodiesterse expression and the role of activated microglia. Hence, a better understanding of the HD pathogenesis mechanisms may lead to the development of targeted therapies. PET imaging follow–up studies with novel selective PET radiotracers such as 11C-IMA–107 and 11C-PBR28 may provide insight on disease progression and identify prognostic biomarkers, elucidate the underlying HD pathology and assess novel pharmaceutical agents and over time. PMID:26683130

  13. PRODUCTION CONSIDERATIONS FOR THE CLASSICAL PET NUCLIDES.

    Energy Technology Data Exchange (ETDEWEB)

    FINN,R.; SCHLYER,D.

    2001-06-25

    Nuclear Medicine is the specialty of medical imaging, which utilizes a variety of radionuclides incorporated into specific compounds for diagnostic imaging and therapeutic applications. During recent years, research efforts associated with this discipline have concentrated on the decay characteristics of particular radionuclides and the design of unique radiolabeled tracers necessary to achieve time-dependent molecular images. The specialty is expanding with specific Positron emission tomography (PET) and SPECT radiopharmaceuticals allowing for an extension from functional process imaging in tissue to pathologic processes and nuclide directed treatments. PET is an example of a technique that has been shown to yield the physiologic information necessary for clinical oncology diagnoses based upon altered tissue metabolism. Most PET drugs are currently produced using a cyclotron at locations that are in close proximity to the hospital or academic center at which the radiopharmaceutical will be administered. In November 1997, a law was enacted called the Food and Drug Administration Modernization Act of 1997 which directed the Food and Drug Administration (FDA) to establish appropriate procedures for the approval of PET drugs in accordance with section 505 of the Federal Food, Drug, and Cosmetic Act and to establish current good manufacturing practice requirements for such drugs. At this time the FDA is considering adopting special approval procedures and cGMP requirements for PET drugs. The evolution of PET radiopharmaceuticals has introduced a new class of ''drugs'' requiring production facilities and product formulations that must be closely aligned with the scheduled clinical utilization. The production of the radionuclide in the appropriate synthetic form is but one critical component in the manufacture of the finished radiopharmaceutical.

  14. Enhancing person-centred communication in NICU

    DEFF Research Database (Denmark)

    Weis, Janne; Zoffmann, Vibeke; Egerod, Ingrid

    2015-01-01

    Aims of this article were (a) to explore how parents of premature infants experience guided family-centred care (GFCC), and (b) to compare how parents receiving GFCC versus standard care (SC) describe nurse-parent communication in the neonatal intensive care unit.......Aims of this article were (a) to explore how parents of premature infants experience guided family-centred care (GFCC), and (b) to compare how parents receiving GFCC versus standard care (SC) describe nurse-parent communication in the neonatal intensive care unit....

  15. Imperial College Reactor Centre annual report. 1984

    International Nuclear Information System (INIS)

    The following new equipment is noted; for atomic absorption spectrometry to supplement the neutron activation analysis, and an additional nuclear data analysis system to improve the quality and speed of the service to users of the Centre's facilities. Users include undergraduates from the University of London, outside bodies such as the British Musueum, as well as departments of Colleges of the University of London. The reactor lost only three days through failures or faults. Two replacement fuel elements were put into the reactor during the year. The report contains brief accounts of 34 research programmes at the Centre. (U.K.)

  16. PET-Studies in parkinson's disease

    International Nuclear Information System (INIS)

    Positron-emission-tomography (PET) has enabled to study the metabolism and blood flow in specific brain areas. Besides, there is a variety of radiotracers that allow quantification of the function of distinct molecules. In respect to Parkinson's disease, PET allowed for the first time to assess the number of dopaminergic neurons in vivo. Thus, helping confirming a dopaminergic deficit, measuring disease progression and also help to determine the function of dopaminergic grafts. Current research has shifted to determine the role of related neurotransmitter systems in the pathophysiology of Parkinson's disease. (orig.)

  17. Pharmacological studies of the lung with PET

    International Nuclear Information System (INIS)

    Positron emission tomography (PET), known to be used for lung ventilation and perfusion studies, can also be used in pharmacology to obtain information that is otherwise not available. The lung takes up biologically active substances which can be inactivated or activated, and synthesises and releases others. Such information in man has been obtained from samples of human lungs, or from in vivo first-pass studies, invasive or not, as well as from in vivo kinetic studies using external detection methods with scintillation cameras. PET provides now quantitative regional data in the human lung

  18. PeneloPET:一种PET专用的蒙特卡罗仿真工具%PeneloPET: a PET-dedicated Monte Carlo simulation Toolkit

    Institute of Scientific and Technical Information of China (English)

    刘豪佳; 赵书俊; 张斌; 周山虎

    2011-01-01

    It introduces PeneloPET, a PET - dedicated Monte Carlo simulation toolkit, which based on PENELOPE , including the features of PeneloPET and the general process of PeneloPET simulation, then we validate PeneloPET to model the GE Healthcare eXplore Vista microPET system. The PeneloPET simulation results a-gree well with the data from real scanners and GATE simulation data. Therefore, it can be concluded that PeneloPET is an accurate tool for PET simulations.%PeneloPET是一种基于PENELOPE的PET专用蒙特卡罗仿真工具.文章介绍了PeneloPET 的主要特点及使用PeneloPET进行PET仿真的一般过程,并以GE Healthcare的双环型eXplore Vista microPET为原型验证了PeneloPET仿真的有效性.仿真结果显示,PeneloPET仿真数据和实际实验结果及GATE仿真结果之间均具有良好的一致性,证明了PeneloPET是一种精确的PET仿真工具.

  19. The impact of {sup 18}F-FDG PET on the management of patients with suspected large vessel vasculitis

    Energy Technology Data Exchange (ETDEWEB)

    Fuchs, Martin; Rasch, Helmut; Berg, Scott; Ng, Quinn K.T.; Mueller-Brand, Jan; Walter, Martin A. [University Hospital, Institute of Nuclear Medicine, Basel (Switzerland); Briel, Matthias [University Hospital Basel, Institute for Clinical Epidemiology and Biostatistics, Basel (Switzerland); McMaster University, Department of Clinical Epidemiology and Biostatistics, Hamilton, ON (Canada); Daikeler, Thomas; Tyndall, Alan [University Hospital Basel, Department of Rheumatology, Basel (Switzerland); Walker, Ulrich A. [Felix Platter Spital, Department of Rheumatology of Basle University, Basel (Switzerland); Raatz, Heike [University Hospital Basel, Institute for Clinical Epidemiology and Biostatistics, Basel (Switzerland); Jayne, David [Addenbrooke' s Hospital, Vasculitis and Lupus Unit, Cambridge (United Kingdom); Koetter, Ina [University Hospital Tuebingen, Department of Internal Medicine II, Tuebingen (Germany); Blockmans, Daniel [University Hospital Gasthuisberg, Department of General Internal Medicine, Leuven (Belgium); Cid, Maria C.; Prieto-Gonzalez, Sergio [Hospital Clinic, University of Barcelona, IDIBAPS, Department of Systemic Autoimmune Diseases, 08036-Barcelona (Spain); Lamprecht, Peter [University Hospital of Schleswig-Holstein, Department of Rheumatology, Luebeck (Germany); Salvarani, Carlo [Arcispedale S. Maria Nuova, Department of Rheumatology, Reggio Emilia (Italy); Karageorgaki, Zaharenia [Agios Dimitrios General Hospital, 1st Department of Internal Medicine, Thessaloniki (Greece); Watts, Richard [University of East Anglia, Norwich Medical School, Norwich (United Kingdom); Ipswich Hospital NHS Trust, Ipswich (United Kingdom); Luqmani, Raashid [Nuffield Orthopaedic Centre, Department of Rheumatology, Oxford (United Kingdom)

    2012-02-15

    We aimed to assess the impact of {sup 18}F-fluorodeoxyglucose (FDG) positron emission tomography (PET) on the management of patients with suspected large vessel vasculitis. An international expert panel determined diagnoses and clinical management in patients with suspected large vessel vasculitis, with and without the results of {sup 18}F-FDG PET, respectively. The accuracy of the clinical diagnosis and the resulting clinical management with and without the {sup 18}F-FDG PET results were compared using logistic regression models. The analysis included 30 patients referred to a tertiary care centre with large vessel vasculitis and 31 controls. {sup 18}F-FDG PET had an overall sensitivity of 73.3% [95% confidence interval (CI) 54.1-87.7%], a specificity of 83.9% (95% CI 66.3-94.5%), a positive predictive value of 81.5% (95% CI 61.9-93.7%) and a negative predictive value of 76.5% (95% CI 58.8-89.3%). The diagnostic accuracy of {sup 18}F-FDG PET was higher in patients not receiving immunosuppressive drugs (93.3 vs 64.5%, p = 0.006). Taken in context with other available diagnostic modalities, the addition of {sup 18}F-FDG PET increased the clinical diagnostic accuracy from 54.1 to 70.5% (p = 0.04). The addition of {sup 18}F-FDG PET increased the number of indicated biopsies from 22 of 61 patients (36.1%) to 25 of 61 patients (41.0%) and changed the treatment recommendation in 8 of 30 patients (26.7%) not receiving immunosuppressive medication and in 7 of 31 patients (22.6%) receiving immunosuppressive medication. {sup 18}F-FDG PET is a sensitive and specific imaging tool for large vessel vasculitis, especially when performed in patients not receiving immunosuppressive drugs. It increases the overall diagnostic accuracy and has an impact on the clinical management in a significant proportion of patients. (orig.)

  20. Deep-inspiration breath-hold PET/CT versus free breathing PET/CT and respiratory gating PET for reference. Evaluation in 95 patients with lung cancer

    International Nuclear Information System (INIS)

    The objective of this study was to define the factors that correlate with differences in maximum standardized uptake value (SUVmax) in deep-inspiration breath-hold (DIBH) and free breathing (FB) positron emission tomography (PET)/CT admixed with respiratory gating (RG) PET for reference. Patients (n=95) with pulmonary lesions were evaluated at one facility over 33 months. After undergoing whole-body PET/CT, a RG PET and FB PET/CT scans were obtained, followed by a DIBH PET/CT scan. All scans were recorded using a list-mode dynamic collection method with respiratory gating. The RG PET was reconstructed using phase gating without attenuation correction; the FB PET was reconstructed from the RG PET sinogram datasets with attenuation correction. Respiratory motion distance, breathing cycle speed, and waveform of RG PET were recorded. The SUVmax of FB PET/CT and DIBH PET/CT were recorded: the percent difference in SUVmax between the FB and DIBH scans was defined as the %BH-index. The %BH-index was significantly higher for lesions in the lower lung area than in the upper lung area. Respiratory motion distance was significantly higher in the lower lung area than in the upper lung area. A significant relationship was observed between the %BH-index and respiratory motion distance. Waveforms without steady end-expiration tended to show a high %BH-index. Significant inverse relationships were observed between %BH-index and cycle speed, and between respiratory motion distance and cycle speed. Decrease in SUVmax of FB PET/CT was due to tumor size, distribution of lower lung, long respiratory movement at slow breathing cycle speeds, and respiratory waveforms without steady end-expiration. (author)

  1. Performance Evaluation of microPET: A High-Resolution Lutetium Oxyorthosilicate PET Scanner for Animal Imaging

    OpenAIRE

    Chatziioannou, Arion F.; Cherry, Simon R.; Shao, Yiping; Silverman, Robert W.; Meadors, Ken; Farquhar, Thomas H.; Pedarsani, Marjan; Phelps, Michael E.

    1999-01-01

    A new dedicated PET scanner, microPET, was designed and developed at the University of California, Los Angeles, for imaging small laboratory animals. The goal was to provide a compact system with superior spatial resolution at a fraction of the cost of a clinical PET scanner.

  2. PET/MRI: A luxury or a necessity?

    Science.gov (United States)

    Carreras-Delgado, J L; Pérez-Dueñas, V; Riola-Parada, C; García-Cañamaque, L

    2016-01-01

    PET/MRI is a new multimodality technique with a promising future in diagnostic imaging. Technical limitations are being overcome. Interference between the two systems (PET and MRI) seems to have been resolved. MRI-based PET attenuation correction can be performed safely. Scan time is acceptable and the study is tolerable, with claustrophobia prevalence similar to that of MRI. Quantification with common parameters, such as Standardized Uptake Value (SUV), shows a fairly good correlation between both systems. However, PET/CT currently provides better results in scan time, scan costs, and patient comfort. Less patient radiation exposure is a big advantage of PET/MRI over PET/CT, which makes it particularly recommended in paediatric and adolescent patients requiring one or more studies. PET/MRI indications are the same as those of PET/CT, given that in cases where MRI is superior to CT, PET/MRI is superior to PET/CT. This superiority is clear in many soft tissue tumours. Moreover, it is common to perform both PET/CT and MRI in neurological diseases, as well as in some tumours, such as breast cancer. A single PET/MRI study replaces both with obvious benefit. MRI also allows other MRI-based PET corrections, such as motion or partial volume effect corrections. The better spatial resolution of MRI allows the transfer of well-defined MRI areas or small volumes of interest to PET image, in order to measure PET biomarkers in these areas. The richness of information of both techniques opens up immense possibilities of synergistic correlation between them. PMID:27349326

  3. Similarities between obesity in pets and children: the addiction model.

    Science.gov (United States)

    Pretlow, Robert A; Corbee, Ronald J

    2016-09-01

    Obesity in pets is a frustrating, major health problem. Obesity in human children is similar. Prevailing theories accounting for the rising obesity rates - for example, poor nutrition and sedentary activity - are being challenged. Obesity interventions in both pets and children have produced modest short-term but poor long-term results. New strategies are needed. A novel theory posits that obesity in pets and children is due to 'treats' and excessive meal amounts given by the 'pet-parent' and child-parent to obtain affection from the pet/child, which enables 'eating addiction' in the pet/child and results in parental 'co-dependence'. Pet-parents and child-parents may even become hostage to the treats/food to avoid the ire of the pet/child. Eating addiction in the pet/child also may be brought about by emotional factors such as stress, independent of parental co-dependence. An applicable treatment for child obesity has been trialled using classic addiction withdrawal/abstinence techniques, as well as behavioural addiction methods, with significant results. Both the child and the parent progress through withdrawal from specific 'problem foods', next from snacking (non-specific foods) and finally from excessive portions at meals (gradual reductions). This approach should adapt well for pets and pet-parents. Pet obesity is more 'pure' than child obesity, in that contributing factors and treatment points are essentially under the control of the pet-parent. Pet obesity might thus serve as an ideal test bed for the treatment and prevention of child obesity, with focus primarily on parental behaviours. Sharing information between the fields of pet and child obesity would be mutually beneficial. PMID:27469280

  4. PET/MRI and PET/CT in follow-up of head and neck cancer patients

    Energy Technology Data Exchange (ETDEWEB)

    Queiroz, Marcelo A. [University Hospital Zurich, Department of Medical Radiology, Nuclear Medicine, Zurich (Switzerland); University Hospital Zurich, Department of Nuclear Medicine, Zurich (Switzerland); Huellner, Martin [University Hospital Zurich, Department of Medical Radiology, Nuclear Medicine, Zurich (Switzerland); University Hospital Zurich, Department of Medical Radiology, Neuroradiology, Zurich (Switzerland); Kuhn, Felix; Veit-Haibach, Patrick [University Hospital Zurich, Department of Medical Radiology, Nuclear Medicine, Zurich (Switzerland); University Hospital Zurich, Department of Medical Radiology, Diagnostic and Interventional Radiology, Zurich (Switzerland); Huber, Gerhardt; Meerwein, Christian [University Hospital Zurich, Department of Otorhinolaryngology, Zurich (Switzerland); Kollias, Spyros [University Hospital Zurich, Department of Medical Radiology, Neuroradiology, Zurich (Switzerland); Schulthess, Gustav von [University Hospital Zurich, Department of Medical Radiology, Nuclear Medicine, Zurich (Switzerland)

    2014-06-15

    Positron emission tomography (PET)/MRI combines the functional ability of PET and the high soft tissue contrast of MRI. The aim of this study was to assess contrast-enhanced (ce)PET/MRI compared to cePET/CT in patients with suspected recurrence of head and neck cancer (HNC). Eighty-seven patients underwent sequential cePET/CT and cePET/MRI using a trimodality PET/CT-MRI set-up. Diagnostic accuracy for the detection of recurrent HNC was evaluated using cePET/CT and cePET/MRI. Furthermore, image quality, presence of unclear {sup 18}F-fluorodeoxy-D-glucose (FDG) findings of uncertain significance and the diagnostic advantages of use of gadolinium contrast enhancement were analysed. cePET/MRI showed no statistically significant difference in diagnostic accuracy compared to cePET/CT (91.5 vs 90.6 %). Artefacts' grade was similar in both methods, but their location was different. cePET/CT artefacts were primarily located in the suprahyoid area, while on cePET/MRI, artefacts were more equally distributed among the supra and infrahyoid neck regions. cePET/MRI and cePET/CT showed 34 unclear FDG findings; of those 11 could be solved by cePET/MRI and 5 by cePET/CT. The use of gadolinium in PET/MRI did not yield higher diagnostic accuracy, but helped to better define tumour margins in 6.9 % of patients. Our data suggest that cePET/MRI may be superior compared to cePET/CT to specify unclear FDG uptake related to possible tumour recurrence in follow-up of patients after HNC. It seems to be the modality of choice for the evaluation of the oropharynx and the oral cavity because of a higher incidence of artefacts in cePET/CT in this area mainly due to dental implants. However, overall there is no statistically significant difference. (orig.)

  5. Open-label study of the short-term effects of memantine on FDG-PET in frontotemporal dementia

    Directory of Open Access Journals (Sweden)

    Chow TW

    2011-07-01

    Full Text Available Tiffany W Chow1–6, Ariel Graff-Guerrero4,6, Nicolaas PLG Verhoeff2–4,7, Malcolm A Binns3,8, David F Tang-Wai5,9, Morris Freedman1,3,5, Mario Masellis5,10, Sandra E Black3,5,10, Alan A Wilson4,6, Sylvain Houle4,6, Bruce G Pollock4,61Division of Neurology, 2Department of Psychiatry, 3Rotman Research Institute, Baycrest; 4Departments of Psychiatry, 5Medicine, Division of Neurology, University of Toronto; 6Centre for Addiction and Mental Health PET Centre; 7Kunin-Lunenfeld Applied Research Unit, Baycrest; 8Dalla Lana School of Public Health, University of Toronto; 9University Health Network Memory Clinic; 10LC Campbell Cognitive Neurology Research Unit, Department of Medicine (Neurology, Sunnybrook Health Sciences Centre, Toronto, ON, CanadaBackground: Memantine has shown effects on cortical metabolism in Alzheimer's disease (AD, and the mechanism of action may not be specific to AD alone. We hypothesized that participants with frontotemporal dementia taking memantine would show an increased cortical metabolic activity in frontal regions, temporal regions, or in salience network hubs.Methods: Sixteen participants with behavioral or language variant frontotemporal dementia syndromes (FTD were recruited from tertiary FTD clinics and treated with memantine hydrochloride 10 mg twice daily in this fixed-dose, open-label pilot study. The primary endpoint was enhancement of cortical metabolic activity after 7–8 weeks of treatment. Secondary endpoints were measures of mood and behavior disturbance, frontal executive function, and motor disturbance.Results: Voxel-wise parametric image analysis of positron emission tomography (PET data from seven behavioral variant FTD patients, eight semantic dementia patients, and one progressive nonfluent aphasia patient, of mean age 64.3 years, mean duration of illness 4.25 years, and baseline mean sum of boxes Clinical Dementia Rating score 6.59, revealed an increase in [18F]-fluorodeoxyglucose (FDG normalized

  6. PET and paediatrics; La tomographie par emission de positons (ou PET scan) en pediatrie

    Energy Technology Data Exchange (ETDEWEB)

    Boddaert, N. [Necker Enfants Malades, AP-HP, Serv Radiol Pediat, Paris (France); Ribeiro, M.J. [CEA, DSV, I2BM, Serv Hosp Frederic Joliot, F-91406 Orsay (France)

    2008-07-01

    Positon emission tomography (PET scan) is a functional imagery technique.As in scintigraphy, a radioactive tracer is administrated to the patient and its distribution into the organism is detected by a tomograph or a PET scanner. The nuclear medicine techniques which use radioactive tracers allow to obtain an imagery of the regional metabolism of glucose, blood flow or of different neurotransmitters. The PET-TDM (tomodensitometry) is an hybrid imagery system which associates a PET to a multi-bars scanner (4 to 64 bars). The use of hybrid imagery systems allows an anatomic register of the metabolic anomalies or others, as well as the adjustment of the attenuation of the emitted particles. (O.M.)

  7. [The coordination of care in health centres].

    Science.gov (United States)

    Ribardière, Olivia

    2016-06-01

    Health centres are structurally designed to facilitate the coordination of care. However, evolutions in society have resulted in forms of consumption of health care which are not necessarily compatible with efficient care coordination. On a local level, teams are nevertheless organising and structuring themselves to offer the right form of care, to the right patient and at the right time. PMID:27338687

  8. Renovation of the CERN Computer Centre

    CERN Multimedia

    Patrice Loïez

    2003-01-01

    The Computer Centre at CERN is seen after half of the equipment is the large ground floor room has been removed. A large-scale spring-cleaning operation took place before renovation work for the new CERN Grid system began. Fifteen kilometres of cables that were no longer needed were removed from the cavity floor for recycling.

  9. The Australian Centre for Minesite Rehabilitation Research

    International Nuclear Information System (INIS)

    The Australian Centre for Minesite Rehabilitation Research (ACMRR) is a joint venture between the Australian mining industry through the Australian Mineral Industries Research Association Ltd. (AMIRA) and three of the organizations working most actively in this area in Australia: CSIRO Minesite Rehabilitation Research Program; University of Queensland Centre for Mined Land Rehabilitation; and Curtin University Mulga Research Centre. The ACMRR was established in July 1993 to provide a national framework to conduct Strategic Research into minesite rehabilitation. It is an industry led and funded initiative. The Goals of the Centre include: to conduct strategic research into minesite rehabilitation to provide sustainable environmental solutions which are acceptable to industry, government and the community; to be recognized as a center of excellence undertaking commissioned research on minesite rehabilitation in an independent and thorough manner; to provide scientific and technological foundations to facilitate industry and government in setting acceptable standards; to act as networking and communications focus; and to enhance education and training in minesite rehabilitation. Strategic Research Programs in: Water Systems--downstream surface and groundwater quality; Land--the long-term behavior and stability of constructed landforms; Ecosystems--the long-term sustainability of constructed landforms; Waste--the long-term treatment and disposal of waste products; will allow the ACMRR to achieve these goals through specific research projects in these areas, developed with industry sponsors. This paper will discuss their progress to date, research projects underway, and plans for the future

  10. Interorganisatorisk styring i Shared Service Centre

    DEFF Research Database (Denmark)

    Harritz, Daniel

    2011-01-01

    I den offentlige sektor er der en stigende udbredelse af Shared Service Centre (SSC). Men der er endnu meget lidt viden om de interorganisatoriske styringsproblemstillinger, der opstår når et SSC oprettes. I denne artikel præsenteres, ud fra et interorganisatorisk perspektiv, en styringsramme der...

  11. [The coordination of care in health centres].

    Science.gov (United States)

    Ribardière, Olivia

    2016-06-01

    Health centres are structurally designed to facilitate the coordination of care. However, evolutions in society have resulted in forms of consumption of health care which are not necessarily compatible with efficient care coordination. On a local level, teams are nevertheless organising and structuring themselves to offer the right form of care, to the right patient and at the right time.

  12. In the Field: The Canadian Ecology Centre.

    Science.gov (United States)

    Magee, Clare

    2000-01-01

    The Canadian Ecology Centre (Ontario) offers year-round residential and day programs in outdoor and environmental education for secondary students, field placement and internship opportunities for college students, and ecotourism programs, while providing employment and tax revenues to the local community. Dubbed consensus environmentalism, the…

  13. Centring the Subject in Order to Educate

    Science.gov (United States)

    Webster, R. Scott

    2007-01-01

    It is important for educators to recognise that the various calls to decentre the subject--or self--should not be interpreted as necessarily requiring the removal of the subject altogether. Through the individualism of the Enlightenment the self was centred. This highly individualistic notion of the sovereign self has now been decentred especially…

  14. The fragility of human-centred design

    NARCIS (Netherlands)

    Steen, M.G.D.

    2008-01-01

    In human-centred design (HCD), researchers and designers develop products in cooperation with the potential users of these products. They attempt to give users a voice or a role in their projects, with the intention of developing products that match users' needs and preferences. This approach is esp

  15. Student-Centred Learning: A Humanist Perspective

    Science.gov (United States)

    Tangney, Sue

    2014-01-01

    The notion of student-centred learning is often not defined; within the pedagogic literature it is generally associated with constructivism or principles associated with a constructivist environment such as building on prior knowledge, purposeful active learning and sense-making. An informal enquiry into conceptions of university staff prior to…

  16. The young centre of the Earth

    DEFF Research Database (Denmark)

    Uggerhøj, Ulrik Ingerslev; Mikkelsen, Rune E.; Faye, Jan

    2016-01-01

    We treat, as an illustrative example of gravitational time dilation in relativity, the observation that the centre of the Earth is younger than the surface by an appreciable amount. Richard Feynman first made this insightful point and presented an estimate of the size of the effect in a talk...

  17. Analysis framework for the J-PET scanner

    CERN Document Server

    Krzemień, W; Gruntowski, A; Stola, K; Trybek, D; Bednarski, T; Białas, P; Czerwiński, E; Kamińska, D; Kapłon, L; Kochanowski, A; Korcyl, G; Kowal, J; Kowalski, P; Kozik, T; Kubicz, E; Moskal, P; Niedźwiecki, Sz; Pałka, M; Raczyński, L; Rudy, Z; Salabura, P; Sharma, N G; Silarski, M; Słomski, A; Smyrski, J; Strzelecki, A; Wieczorek, A; Wiślicki, W; Zieliński, M; Zoń, N

    2015-01-01

    J-PET analysis framework is a flexible, lightweight, ROOT-based software package which provides the tools to develop reconstruction and calibration procedures for PET tomography. In this article we present the implementation of the full data-processing chain in the J-PET framework which is used for the data analysis of the J-PET tomography scanner. The Framework incorporates automated handling of PET setup parameters' database as well as high level tools for building data reconstruction procedures. Each of these components is briefly discussed.

  18. Biodegradation of DTP and PET Fiber by Microbe

    Institute of Scientific and Technical Information of China (English)

    张健飞; 王晓春; 巩继贤; 顾振亚

    2003-01-01

    The degradation of diethylene glycol terephthalate (DTP) and polyethylene terephthalate (PET) fiber by microbe was studied.The degree of DTP degradation was determined by High Performance Liquid Chromatography (HPLC) to be more than 90%.The products after degradation of DTP and PET fiber were various.The degradation of DTP can be described by the first-order reaction model.The degradation of PET fiber was found to be little,but surface erosion of PET fiber could be clearly seen from the SEM photographs indicating there occurred some traces of biodegradation on the PET fiber surface.

  19. Improving the Spatial Alignment in PET/CT Using Amplitude-Based Respiration-Gated PET and Respiration-Triggered CT

    NARCIS (Netherlands)

    Vos, C.S. van der; Grootjans, W.; Osborne, D.R.; Meeuwis, A.P.; Hamill, J.J.; Acuff, S.; Geus-Oei, L.F. de; Visser, E.P.

    2015-01-01

    Respiratory motion during PET can cause inaccuracies in the quantification of radiotracer uptake, which negatively affects PET-guided radiotherapy planning. Quantitative accuracy can be improved by respiratory gating. However, additional miscalculation of standardized uptake value (SUV) in PET image

  20. High management impact of Ga-68 DOTATATE (GaTate) PET/CT for imaging neuroendocrine and other somatostatin expressing tumours

    International Nuclear Information System (INIS)

    Ga-68 DOTATATE (Ga-octreotate, GaTate) positron emission tomography (PET)/CT has multiple advantages compared with conventional and In-111 octreotide imaging for neuroendocrine tumours and other somatostatin-receptor expressing tumours. This study assesses the management impact of incremental diagnostic information obtained from this technique compared with conventional staging. Fifty-nine GaTate PET/CT studies were performed over an 18-month period (52 proven or suspected gastro-entero-pancreatic or bronchial neuroendocrine tumours and seven neural crest/mesenchymal tumours). A retrospective blinded review was performed on the number of abnormalities (1, 2–5 or >5) within defined regions with comparison to conventional imaging to assess incremental diagnostic information. Subsequent management impact (high, moderate or low) was determined by clinical review and follow up to assess pre-PET stage, treatment intent and post-PET management change. Eighty-eight percent of GaTate studies were abnormal. Compared with conventional and In-111 octreotide imaging, additional information was provided by GaTate PET/CT in 68 and 83% of patients, respectively. Management impact was high (inter-modality change) in 47%, moderate (intra-modality change) in 10% and low in 41% (not assessable in 2%). High management impact included directing patients to curative surgery by identifying a primary site and directing patients with multiple metastases to systemic therapy. GaTate PET/CT imaging provides additional diagnostic information in a high proportion of patients with consequent high management impact. GaTate PET/CT could replace In-111 octreotide scintigraphy at centres where it is available given its superior accuracy, faster acquisition and lower radiation exposure. Rapid implementation could be achieved by allowing substitutional funding in the Medicare Benefit Schedule.

  1. Comparison of {sup 18}F-FACBC and {sup 11}C-choline PET/CT in patients with radically treated prostate cancer and biochemical relapse: preliminary results

    Energy Technology Data Exchange (ETDEWEB)

    Nanni, Cristina; Boschi, Stefano [Azienda Ospedaliero-Universitaria di Bologna Policlinico S.Orsola-Malpighi, OU Nuclear Medicine, Bologna (Italy); Schiavina, Riccardo; Ambrosini, Valentina; Brunocilla, Eugenio; Martorana, Giuseppe; Fanti, Stefano [Azienda Ospedaliero-Universitaria di Bologna Policlinico S.Orsola-Malpighi, OU Urology, Bologna (Italy); Pettinato, Cinzia [Azienda Ospedaliero-Universitaria di Bologna Policlinico S.Orsola-Malpighi, OU Medical Physics, Bologna (Italy)

    2013-07-15

    We assessed the rate of detection rate of recurrent prostate cancer by PET/CT using anti-3-{sup 18}F-FACBC, a new synthetic amino acid, in comparison to that using {sup 11}C-choline as part of an ongoing prospective single-centre study. Included in the study were 15 patients with biochemical relapse after initial radical treatment of prostate cancer. All the patients underwent anti-3-{sup 18}F-FACBC PET/CT and {sup 11}C-choline PET/CT within a 7-day period. The detection rates using the two compounds were determined and the target-to-background ratios (TBR) of each lesion are reported. No adverse reactions to anti-3-{sup 18}F-FACBC PET/CT were noted. On a patient basis, {sup 11}C-choline PET/CT was positive in 3 patients and negative in 12 (detection rate 20 %), and anti-3-{sup 18}F-FACBC PET/CT was positive in 6 patients and negative in 9 (detection rate 40 %). On a lesion basis, {sup 11}C-choline detected 6 lesions (4 bone, 1 lymph node, 1 local relapse), and anti-3-{sup 18}F-FACBC detected 11 lesions (5 bone, 5 lymph node, 1 local relapse). All {sup 11}C-choline-positive lesions were also identified by anti-3-{sup 18}F-FACBC PET/CT. The TBR of anti-3-{sup 18}F-FACBC was greater than that of {sup 11}C-choline in 8/11 lesions, as were image quality and contrast. Our preliminary results indicate that anti-3-{sup 18}F-FACBC may be superior to {sup 11}C-choline for the identification of disease recurrence in the setting of biochemical failure. Further studies are required to assess efficacy of anti-3-{sup 18}F-FACBC in a larger series of prostate cancer patients. (orig.)

  2. Supplemental transmission method for improved PET attenuation correction on an integrated MR/PET

    International Nuclear Information System (INIS)

    Although MR image segmentation, combined with information from the PET emission data, has achieved a clinically usable PET attenuation correction (AC) on whole-body MR/PET systems, more accurate PET AC remains one of the main instrumental challenges for quantitative imaging. Incorporating a full conventional PET transmission system in these machines would be difficult, but even a small amount of transmission data might usefully complement the MR-based estimate of the PET attenuation image. In this paper we explore one possible configuration for such a system that uses a small number of fixed line sources placed around the periphery of the patient tunnel. These line sources are implemented using targeted positron beams. The sparse transmission (sTX) data are collected simultaneously with the emission (EM) acquisition. These data, plus a blank scan, are combined with a partially known attenuation image estimate in a modified version of the maximum likelihood for attenuation and activity (MLAA) algorithm, to estimate values of the linear attenuation coefficients (LAC) in unknown regions of the image. This algorithm was tested in two simple phantom experiments. We find that the use of supplemental transmission data can significantly improve the accuracy of the estimated LAC in a truncated region, as well as the estimate of the emitter concentration within the phantom. In the experiments, the bias in the EM+sTX estimate of emitter concentrations was 3–5%, compared to 15–20% with the use of EM-only data. Highlights: • MR-based PET attenuation correction (AC) on MR/PET scanners remains problematic. • We propose a supplemental sparse transmission (sTX) system to improve MR-AC. • The sTX sources were implemented very practically using targeted positron beams. • A novel MLAA-like algorithm was developed to reconstruct these data. • We show that sTX leads to more accurate emission images in two phantom studies

  3. Pets, policies and tenants: report on PATHWAY housing provider - 'Pet Policy' survey

    OpenAIRE

    McBride, E. A.; Bryant, I.

    2004-01-01

    The Pet Foods Manufacturers’ Association (2003) estimates 50% of UK households have a pet. Whilst most have traditional ‘domestic’ species, there is an increasing trend for exotic species including invertebrates, snakes, parrots and raptors. Insufficient knowledge of species’ needs may result in poor animal welfare. Health and safety issues potentially compromise human welfare, such as zoonotic disease or bite injury. Escaped small mammals can chew through wiring, causing a fire hazard to all...

  4. Person-centred care in nursing documentation.

    LENUS (Irish Health Repository)

    Broderick, Margaret C

    2012-12-07

    BACKGROUND: Documentation is an essential part of nursing. It provides evidence that care has been carried out and contains important information to enhance the quality and continuity of care. Person-centred care (PCC) is an approach to care that is underpinned by mutual respect and the development of a therapeutic relationship between the patient and nurse. It is a core principle in standards for residential care settings for older people and is beneficial for both patients and staff (International Practice Development in Nursing and Healthcare, Chichester, Blackwell, 2008 and The Implementation of a Model of Person-Centred Practice in Older Person Settings, Dublin, Health Service Executive, 2010a). However, the literature suggests a lack of person-centredness within nursing documentation (International Journal of Older People Nursing 2, 2007, 263 and The Implementation of a Model of Person-Centred Practice in Older Person Settings, Dublin, Health Service Executive, 2010a). AIMS AND OBJECTIVES: To explore nursing documentation in long-term care, to determine whether it reflected a person-centred approach to care and to describe aspects of PCC as they appeared in nursing records. METHOD: A qualitative descriptive study using the PCN framework (Person-centred Nursing; Theory and Practice, Oxford, Wiley-Blackwell, 2010) as the context through which nursing assessments and care plans were explored. RESULTS: Findings indicated that many nursing records were incomplete, and information regarding psychosocial aspects of care was infrequent. There was evidence that nurses engaged with residents and worked with their beliefs and values. However, nursing documentation was not completed in consultation with the patient, and there was little to suggest that patients were involved in decisions relating to their care. IMPLICATIONS FOR PRACTICE: The structure of nursing documentation can be a major obstacle to the recording of PCC and appropriate care planning. Documentation

  5. Nuclear Electric Visitor Centres - Innovation and inspiration

    International Nuclear Information System (INIS)

    Full text: This eight minute video demonstrates the approach taken by Nuclear Electric to exhibitions that are open to the public. The information is given both visually - with excerpts from some of the attractions on display at the centres - and in comments from interviews with visitors, the centre guides and the man responsible for many of the exhibits featured in the video. on one side are the schoolchildren who are visiting the exhibition and are seen both playing and learning as they press buttons, watch videos, 'meet' Michael Faraday, and learn about radiation - its disposal and its safe transportation. The headmaster of the school is interviewed and explains that the exhibition is helping his children understand the importance of electricity to their world. on the other side is Jackie Lucas, the visitor centre manager, explaining what the public make of the exhibition. We see her staff greeting the children and helping them to understand the show. The designer of the exhibition, Len Upton explains how you go about making an exhibition such as this both informative and fun. Also interviewed is the man behind many of the exhibitions featured at Nuclear Electric's visitor centres up and down the country, Nicholas Mullane. He explains the purpose of the exhibition and what messages it imparts. The video is presented in split-screen or composite format, whereby the interviewee and children are often presented together. Excerpts from the various videos on display are presented as both how they are seen from the floor, as well as the full screen effect of the various programmes. The video gives much of the feeling of fun to be gained at the exhibition, as well as showing the educational benefits to be gained from a couple of hours at one of Nuclear Electric's visitor centres. Copies of the video can be obtained from Bob Fenton at Nuclear Electric. (Fax: ++44 1 452 652 443). (author)

  6. Clinical PET activities in European and Asia-Oceanian Countries

    International Nuclear Information System (INIS)

    Clinical diagnosis using positron emission tomography (PET) requires high costs. Therefore, sociomedical evaluation is very important for spread of clinical PET. In this report, sociomedical situation in European and Asia-Oceanian countries, especially concerning transportation of 18F-FDG and reimbursement of medical costs for clinical PET indications, is reported. It seems that UK, Germany and Belgium are the most advanced in clinical PET in Europe. In these countries, many PET investigations are reimbursed though systems are different among the countries. In UK, both public and private insurance gives authorization for clinical PET to some extent. In Germany, private health insurance companies give authorization but public insurance has not. In Belgium, private health insurance does not exist and public insurance gives authorization for clinical PET. Other European countries seem to be in transitional stages. Transportation of 18F-FDG has been already started in almost every country in Europe and Asia-Oceania. In Japan, neither transportation of FDG nor full reimbursement of clinical PET has not started yet and this situation seems to be exceptional. To promote clinical PET in Japan, there is the need of at least establishing a list of clinical indications for PET investigations and establishing commercial-based 18F-FDG supplying system. They could be regarded as a kind of infrastructure for spread of clinical PET. (author)

  7. PET/MRI: Technical challenges and recent advances

    Energy Technology Data Exchange (ETDEWEB)

    Jung, Jin Ho; Choi, Yong; Im, Ki Chun [Molecular Imaging Research and Education Laboratory, Dept. of Electronic Engineering, Sogang University, Seoul (Korea, Republic of)

    2016-03-15

    Integrated positron emission tomography (PET)/magnetic resonance imaging (MRI), which can provide complementary functional and anatomical information about a specific organ or body system at the molecular level, has become a powerful imaging modality to understand the molecular biology details, disease mechanisms, and pharmacokinetics in animals and humans. Although the first experiment on the PET/MRI was performed in the early 1990s, its clinical application was accomplished in recent years because there were various technical challenges in integrating PET and MRI in a single system with minimum mutual interference between PET and MRI. This paper presents the technical challenges and recent advances in combining PET and MRI along with several approaches for improving PET image quality of the PET/MRI hybrid imaging system.

  8. Research Progress of PET Traces for Alzheimer’s Disease

    Directory of Open Access Journals (Sweden)

    TANG Cai-hua1,2;HU Kong-zhen1;TANG Gang-hua1

    2014-02-01

    Full Text Available Alzheimer’s disease (AD is unknown cause progressive degenerative diseases of central nervous system. It is a serious threat to the health of the elderly people. The diagnosis is mainly based on pathological examination after death. With the wide application of positron emission tomography (PET imaging in clinic, in vivo noninvasive imaging diagnosis of AD at the early stage become possible. PET imaging mainly depends on the positron-labeled imaging agents. The PET imaging agents can be used in the early diagnosis and differential diagnosis on AD include several kinds: PET traces for glucose metabolic, PET traces combined with amyloid proteinplaques,tau protein, neurotransmitter and receptor, activation of microglia and PET traces for cell apoptosis.The research progress of various PET tracers were reviewed that can be used in the early diagnosis and differential diagnosis on AD in recent years.

  9. Cost-effective analysis of PET application in NSCLC

    International Nuclear Information System (INIS)

    Objective: To evaluate the cost-effectiveness of PET and CT application for diagnosis of non-small cell lung cancer (NSCLC) in China. Methods: Using decision analysis method the diagnostic efficiency of PET and CT for diagnosis of NSCLC in china was analysed. And also the value of cost for accurate diagnosis (CAD), cost for accurate staging (CAS) and cost for effective therapy (CAT) was calculated. Results: (1) For the accurate diagnosis, CT was much more cost-effective than PET. (2) For the accurate staging, CT was still more cost-effective than PET. (3) For the all over diagnostic and therapeutic cost, PET was more cost-effective than CT. (4) The priority of PET to CT was for the diagnosis of stage I NSCLC. Conclusion: For the management of NSCLC patient in China, CT is more cost-effective for screening, whereas PET for clinical staging and monitoring therapeutic effect. (authors)

  10. Validation of PSF-based 3D reconstruction for myocardial blood flow measurements with Rb-82 PET

    DEFF Research Database (Denmark)

    Tolbod, Lars Poulsen; Christensen, Nana Louise; Møller, Lone W.;

    is not well validated and problems with both edge-effects and unphysical contrast-recovery have been reported.1 In this study, we compare myocardial blood flow (MBF) and coronary flow reserve (CFR) obtained using GEs implementation of PSF, SharpIR, with the conventional method for reconstruction of dynamic...... images, filtered backprojection (FBP). Furthermore, since myocardial segmentation might be affected by image quality, two different approaches to segmentation implemented in standard software (Carimas (Turku PET Centre) and QPET (Cedar Sinai)) are utilized. Method:14 dynamic rest-stress Rb-82 patient...

  11. PhytoPET: Design and initial results of modular PET for plant biology

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Seung Joon [JLAB; Kross, Brian J. [JLAB; McKisson, John E. [JLAB; Weisenberger, Andrew G. [JLAB; Xi, Wenze [JLAB; Zorn, Carl J. [JLAB; Howell, C. R.; Reid, C. D.; Smith, M. P.

    2012-11-01

    We have developed a positron emission tomography (PET) system designed specifically for plant imaging in Phytotron at Duke University. Initial evaluation of a PhytoPET system to image the biodistribution of the positron emitting tracer {sup 11}C in live plants is presented. The mechanical arrangement of the detectors is designed to accommodate the unpredictable and random distribution in space of the plant parts such as stems, leaves, and roots. Prototyping such a system requires a completely new PET system design strategy different from preclinical and clinical applications. This PhytoPET design allows flexible arrangements of PET detectors based on individual standalone detector modules built from single 5 cm × 5 cm Hamamatsu H8500 position sensitive photomultiplier tubes. Each H8500 is coupled to a L YSO:Ce scintillator array composed of 48 × 48 elements that are 10 mm thick with a 1 mm pitch. Initial results provide planar PET images from two different arrangements (1 × 4 or 2 × 2) for flexible imaging capability.

  12. Cardiovascular hybrid imaging using PET/MRI; Kardiovaskulaere Hybridbildgebung mit PET/MRT

    Energy Technology Data Exchange (ETDEWEB)

    Nensa, Felix; Schlosser, Thomas [Universitaetsklinikum Essen (Germany). Inst. fuer Diagnostische und Interventionelle Radiologie und Neuroradiologie

    2014-12-15

    The following overview provides a summary of the state of the art and research as well as potential clinical applications of cardiovascular PET/MR imaging. PET/MRI systems have been clinically available for a few years, and their use in cardiac imaging has been successfully demonstrated. At this period in time, some of the technical difficulties that arose at the beginning have been solved; in particular with respect to MRI-based attenuation correction, caution should be exercised with PET quantification. In addition, many promising technical options are still in the developmental stage, such as MRI-based motion correction of PET data resulting from simultaneous MR acquisition, and are not yet available for cardiovascular imaging. On the other hand, PET/MRI has been used to demonstrate significant pathologies such as acute and chronic myocardial infarction, myocarditis or cardiac sarcoidosis; future applications in clinical routine or within studies appear to be possible. In coming years additional studies will have to be performed to prove diagnostic gain at a reasonable cost-benefit ratio before valid conclusions are possible regarding the clinical utility and future of cardiovascular PET/MR imaging.

  13. A PET scanner developed by CERN

    CERN Multimedia

    Laurent Guiraud

    1998-01-01

    This image shows a Position Emission Tomography (PET) scanner at the Hopital Cantonal Universitaire de Genève. Development of the multiwire proportional chamber at CERN in the mid-1970s was soon seen as a potential device for medical imaging. It is much more sensitive than previous devices and greatly reduced the dose of radiation received by the patient.

  14. PET imaging in patients with Modic changes

    DEFF Research Database (Denmark)

    Albert, Hanne; Pedersen, Henrik; Manniche, Claus;

    2009-01-01

    The aim of this study was via PET imaging to reveal if any highly metabolic processes were occurring in Modic changes type 1 and/or in the adjacent discs. Modic changes (MC) are signal changes in the vertebral endplate and body visualised by magnetic resonance imaging (MRI). MC are strongly...... disc. All patients had a PET scan using FDG (18F-fluorodeoxyglucose) as tracer. RESULTS: Included in the study were 11 patients, 4 women and 7 men, mean age 48.1 year (range 20-65). All MC were situated in the vertebrae both above and below the previously herniated disc/discs. Ten patients had MC at 1...... level, and 1 had MC at 2 levels. The affected levels were 1 at L2/L3, 6 at L4 /L5, and 5 at L5/S1. All had a previous disc herniation and MC larger than 4 mm in diameter. Technically satisfactory PET scans were obtained. However, PET imaging showed no increases in metabolism in any vertebra or disc...

  15. Maillard reaction products in pet foods

    NARCIS (Netherlands)

    Rooijen, van C.

    2015-01-01

    Pet dogs and cats around the world are commonly fed processed commercial foods throughout their lives. Often heat treatments are used during the processing of these foods to improve nutrient digestibility, shelf life, and food safety. Processing is known to induce the Maillard reaction, in which a r

  16. PET and SPECT of neurobiological systems

    International Nuclear Information System (INIS)

    Addresses a variety of aspects of neurotransmission in the brain. Details the latest results in probe development. Emphasis on a multidisciplinary approach. Written by internationally acclaimed experts. PET and SPECT of Neurobiological Systems combines the expertise of renowned authors whose dedication to the development of novel probes and techniques for the investigation of neurobiological systems has achieved international recognition. Various aspects of neurotransmission in the brain are discussed, such as visualization and quantification of (more than 20 different) neuroreceptors, neuroinflammatory markers, transporters, and enzymes as well as neurotransmitter synthesis, ?-amyloid deposition, cerebral blood flow, and the metabolic rate of glucose. The latest results in probe development are also detailed. Most chapters are written jointly by radiochemists and nuclear medicine specialists to ensure a multidisciplinary approach. This state of the art compendium will be valuable to anyone in the field of clinical or preclinical neuroscience, from the radiochemist and radiologist/nuclear medicine specialist to the interested neurobiologist and general practitioner. It is the second volume of a trilogy on PET and SPECT imaging in the neurosciences. Other volumes focus on PET and SPECT in psychiatry and PET and SPECT in neurology''.

  17. People Can Catch Diseases from Their Pets

    Centers for Disease Control (CDC) Podcasts

    2013-01-23

    Dr. Carol Rubin, Associate Director for Zoonoses and One Health at CDC, discusses zoonotic diseases in pets.  Created: 1/23/2013 by National Center for Emerging and Zoonotic Infectious Diseases (NCEZID).   Date Released: 1/28/2013.

  18. Thin Time-Of-Flight PET project

    CERN Multimedia

    The pre-R&D aims at designing and producing a compact and thin Time-Of-Flight PET detector device with depth of interaction measurement capability, which employs layered silicon sensors as active material, with a readout consisting of a new generation of very-low noise and very fast electronics based on SiGe Heterojunction Bipolar Transistors (HBT) components.

  19. Appropriate Use Criteria for Amyloid PET

    Science.gov (United States)

    Johnson, Keith A.; Minoshima, Satoshi; Bohnen, Nicolaas I.; Donohoe, Kevin J.; Foster, Norman L.; Herscovitch, Peter; Karlawish, Jason H.; Rowe, Christopher C.; Carrillo, Maria C.; Hartley, Dean M.; Hedrick, Saima; Mitchell, Kristi; Pappas, Virginia; Thies, William H.

    2013-01-01

    Positron Emission Tomography (PET) of brain amyloid-beta is a technology that is becoming more available, but its clinical utility in medical practice requires careful definition. In order to provide guidance to dementia care practitioners, patients and caregivers, the Alzheimer Association and the Society of Nuclear Medicine and Molecular Imaging convened the Amyloid Imaging Taskforce (AIT). The AIT considered a broad range of specific clinical scenarios in which amyloid PET could potentially be appropriately used. Peer-reviewed, published literature was searched to ascertain available evidence relevant to these scenarios, and the AIT developed a consensus of expert opinion. While empirical evidence of impact on clinical outcomes is not yet available, a set of specific Appropriate Use Criteria (AUC) were agreed upon that define the types of patients and clinical circumstances in which amyloid PET could be used. Both appropriate and inappropriate uses were considered and formulated, and are reported and discussed here. Because both dementia care and amyloid PET technology are in active development, these AUC will require periodic reassessment. Future research directions are also outlined, including diagnostic utility and patient-centered outcomes. PMID:23360977

  20. Prevent Heartworms in Pets Year-Round

    Science.gov (United States)

    ... Consumer Updates by E-mail Consumer Updates RSS Feed Print & Share (PDF 296 K) En Español On this page: Putting Pets at Risk An Indoor Issue as Well FDA-Approved Heartworm Preventatives for Dogs and Cats If you’ve been to a veterinarian’s office, ...

  1. Combined PET/MR imaging in neurology

    DEFF Research Database (Denmark)

    Andersen, Flemming Littrup; Ladefoged, Claes Nøhr; Beyer, Thomas;

    2014-01-01

    AIM: Combined PET/MR systems have now become available for clinical use. Given the lack of integrated standard transmission (TX) sources in these systems, attenuation and scatter correction (AC) must be performed using the available MR-images. Since bone tissue cannot easily be accounted for duri...

  2. OCCURENCE OF MERCURY IN PET FOOD

    Directory of Open Access Journals (Sweden)

    M.C. Abete

    2013-02-01

    Full Text Available Mercury levels in 61 complete pet feed containing fish were evaluated. In five samples a mercury content exceeding the maximum residues level (0.4 mg/kg was detected. The statistical evaluation didn’t show a significant correlation between the percentage of fish in feedingstuffs and the contamination level.

  3. SPECT and PET in Eating Disorders

    NARCIS (Netherlands)

    van Waarde, Aren; Audenaert, Kurt; Busatto, Geraldo F.; Buchpiguel, Carlos; Dierckx, Rudi; Dierckx, Rudi AJO; Otte, Andreas; de Vries, Erik FJ; van Waarde, Aren; den Boer, Johan A

    2014-01-01

    Medical imaging techniques like PET and SPECT have been applied for investigation of brain function in anorexia and bulimia nervosa. Regional abnormalities have been detected in cerebral blood flow, glucose metabolism, the availability of several neurotransmitter receptors (serotonin 1A and 2A, dopa

  4. Captive Conditions of Pet Lemurs in Madagascar.

    Science.gov (United States)

    Reuter, Kim E; Schaefer, Melissa S

    2016-01-01

    Live extraction of wildlife is a threat to biodiversity and can compromise animal welfare standards. Studies of the captive environments and welfare of pet primates are known, but none has focused on Madagascar. We aimed to expand knowledge about the captive conditions of pet lemurs in Madagascar. We hypothesized that captive lemurs would often be kept in restrictive settings, including small cages, would be fed foods inconsistent with their natural diets and, as a result, would be in bad physical or psychological health. Data were collected via a web-based survey (n = 253 reports) and from the websites and social media pages of 25 hotels. Most lemurs seen by respondents were either kept on a rope/leash/chain or in a cage (67%), though some lemurs were habituated and were not restrained (28%). Most of the time (72%) cages were considered small, and lemurs were rarely kept in captivity together with other lemurs (81% of lemurs were caged alone). Pet lemurs were often fed foods inconsistent with their natural diets, and most (53%) were described as being in bad health. These findings point to a need to undertake outreach to pet lemur owners in Madagascar about the captivity requirements of primates. PMID:27092548

  5. PET Scan and Autoimmune Focal Encephalitis

    OpenAIRE

    J Gordon Millichap

    2010-01-01

    The value of the PET scan in the diagnosis of autoimmune focal encephalitis is reported in a 22-month-old girl who presented with involuntary movements, hemiparesis, and behavioral changes at Juntendo University School of Medicine, Tokyo Metropolitan Institute for Neuroscience, Japan.

  6. New developments in radiotracers for PET

    International Nuclear Information System (INIS)

    PET (Positron Emission Tomography) is a medical imaging method in which a radiotracer tagged with a short-lived positron emitting isotope is used to track a specific biochemical process or the distribution and kinetics of a drug in a living human or animal subject. PET can be applied to an almost limitless variety of problems in biology and medicine because of the chemical flexibility of positron emitters such as carbon-11 (half-life: 20.4 min) and fluorine-18 (half-life: 110 min). Today radiotracers have been developed for probing a diversity of biochemical transformations including blood flow, sugar metabolism, neurotransmission and enzyme activity. In addition PET is finding increasing application in the study of therapeutic drugs and substances of abuse. Dopamine metabolism has been an area of intense interest because of derangements in diseases such as schizophrenia and Parkinson's disease. This has been probed from a number of perspectives with carbon-11 and fluorine-18 labeled tracers which participate selectively in dopamine metabolism, or bind to the dopamine reuptake system or post-synaptic receptors. Advances in the design of highly selective radiotracers, in rapid organic synthesis and sophisticated analytical methods and in mechanistic biochemical studies in vivo have all contributed to the advancement of PET and to its application to new problems in basic and clinical research

  7. PET and SPECT of neurobiological systems

    Energy Technology Data Exchange (ETDEWEB)

    Dierckx, Rudi A.J.O. [Groningen Univ. (Netherlands). Dept. of Nuclear Medicine and Molecular Imaging; Gent Univ. (Belgium). Dept. of Nuclear Medicine; Otte, Andreas [Univ. of Applied Sciences, Offenburg (Germany). Faculty of Electrical Engineering and Information Technology; Vries, Erik F.J. de; Waarde, Aren van (eds.) [Groningen Univ. (Netherlands). Dept. of Nuclear Medicine and Molecular Imaging

    2014-04-01

    Addresses a variety of aspects of neurotransmission in the brain. Details the latest results in probe development. Emphasis on a multidisciplinary approach. Written by internationally acclaimed experts. PET and SPECT of Neurobiological Systems combines the expertise of renowned authors whose dedication to the development of novel probes and techniques for the investigation of neurobiological systems has achieved international recognition. Various aspects of neurotransmission in the brain are discussed, such as visualization and quantification of (more than 20 different) neuroreceptors, neuroinflammatory markers, transporters, and enzymes as well as neurotransmitter synthesis, ?-amyloid deposition, cerebral blood flow, and the metabolic rate of glucose. The latest results in probe development are also detailed. Most chapters are written jointly by radiochemists and nuclear medicine specialists to ensure a multidisciplinary approach. This state of the art compendium will be valuable to anyone in the field of clinical or preclinical neuroscience, from the radiochemist and radiologist/nuclear medicine specialist to the interested neurobiologist and general practitioner. It is the second volume of a trilogy on PET and SPECT imaging in the neurosciences. Other volumes focus on PET and SPECT in psychiatry and PET and SPECT in neurology''.

  8. PET tracer for imaging of neuroendocrine tumors

    DEFF Research Database (Denmark)

    2013-01-01

    There is provided a radiolabelled peptide-based compound for diagnostic imaging using positron emission tomography (PET). The compound may thus be used for diagnosis of malignant diseases. The compound is particularly useful for imaging of somatostatin overexpression in tumors, wherein the compound...

  9. Importance of PET/CT for imaging of colorectal cancer; Stellenwert der PET/CT zur Bildgebung des kolorektalen Karzinoms

    Energy Technology Data Exchange (ETDEWEB)

    Meinel, F.G.; Schramm, N.; Graser, A.; Reiser, M.F.; Rist, C. [Klinikum der Ludwig-Maximilians-Universitaet Muenchen, Campus Grosshadern, Institut fuer Klinische Radiologie, Muenchen (Germany); Haug, A.R. [Klinikum der Ludwig-Maximilians-Universitaet Muenchen, Campus Grosshadern, Klinik und Poliklinik fuer Nuklearmedizin, Muenchen (Germany)

    2012-06-15

    Fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) has emerged as a very useful imaging modality in the management of colorectal carcinoma. Data from the literature regarding the role of PET/CT in the initial diagnosis, staging, radiotherapy planning, response monitoring and surveillance of colorectal carcinoma is presented. Future directions and economic aspects are discussed. Computed tomography (CT), magnetic resonance imaging (MRI) and FDG-PET for colorectal cancer and endorectal ultrasound for rectal cancer. Combined FDG-PET/CT. While other imaging modalities allow superior visualization of the extent and invasion depth of the primary tumor, PET/CT is most sensitive for the detection of distant metastases of colorectal cancer. We recommend a targeted use of PET/CT in cases of unclear M staging, prior to metastasectomy and in suspected cases of residual or recurrent colorectal carcinoma with equivocal conventional imaging. The role of PET/CT in radiotherapy planning and response monitoring needs to be determined. Currently there is no evidence to support the routine use of PET/CT for colorectal screening, staging or surveillance. To optimally exploit the synergy between morphologic and functional information, FDG-PET should generally be performed as an integrated FDG-PET/CT with a contrast-enhanced CT component in colorectal carcinoma. (orig.) [German] Die Fluordesoxyglukose-Positronenemissionstomographie/Computertomographie (FDG-PET/CT) hat in den letzten Jahren zunehmende Bedeutung zur Bildgebung des kolorektalen Karzinoms erlangt. In diesem Beitrag stellen wir den Stand der Literatur zur Rolle der PET/CT bei Screening, Staging, Bestrahlungsplanung, Beurteilung eines Therapieansprechens und Nachsorge des kolorektalen Karzinoms dar. Zudem wird auf gesundheitsoekonomische Aspekte und zukuenftige Entwicklungen eingegangen. CT, MRT, FDG-PET, beim Rektumkarzinom zusaetzlich endorektaler Ultraschall. Kombinierte FDG-PET/CT. Waehrend

  10. Regional climate model data used within the SWURVE project – 1: projected changes in seasonal patterns and estimation of PET

    Directory of Open Access Journals (Sweden)

    2007-01-01

    Full Text Available Climate data for studies within the SWURVE (Sustainable Water: Uncertainty, Risk and Vulnerability in Europe project, assessing the risk posed by future climatic change to various hydrological and hydraulic systems were obtained from the regional climate model HadRM3H, developed at the Hadley Centre of the UK Met Office. This paper gives some background to HadRM3H; it also presents anomaly maps of the projected future changes in European temperature, rainfall and potential evapotranspiration (PET, estimated using a variant of the Penman formula. The future simulations of temperature and rainfall, following the SRES A2 emissions scenario, suggest that most of Europe will experience warming in all seasons, with heavier precipitation in winter in much of western Europe (except for central and northern parts of the Scandinavian mountains and drier summers in most parts of western and central Europe (except for the north-west and the eastern part of the Baltic Sea. Particularly large temperature anomalies (>6°C are projected for north-east Europe in winter and for southern Europe, Asia Minor and parts of Russia in summer. The projected PET displayed very large increases in summer for a region extending from southern France to Russia. The unrealistically large values could be the result of an enhanced hydrological cycle in HadRM3H, affecting several of the input parameters to the PET calculation. To avoid problems with hydrological modelling schemes, PET was re-calculated, using empirical relationships derived from observational values of temperature and PET.

  11. Simultaneous PET/MRI with 13C magnetic resonance spectroscopic imaging (hyperPET): phantom-based evaluation of PET quantification

    DEFF Research Database (Denmark)

    Hansen, Adam E.; Andersen, Flemming L.; Henriksen, Sarah T.;

    2016-01-01

    -MRSI phantoms including a NEMA [18F]-FDG phantom, 13C-acetate and 13C-urea sources, and hyperpolarized 13C-pyruvate were imaged repeatedly with PET and/or 13C-MRSI. Measurements evaluated for interference effects included PET activity values in the largest sphere and a background region; total number of PET......Background: Integrated PET/MRI with hyperpolarized 13C magnetic resonance spectroscopic imaging (13C-MRSI) offers simultaneous, dual-modality metabolic imaging. A prerequisite for the use of simultaneous imaging is the absence of interference between the two modalities. This has been documented...... for a clinical whole-body system using simultaneous 1 H-MRI and PET but never for 13C-MRSI and PET. Here, the feasibility of simultaneous PET and 13C-MRSI as well as hyperpolarized 13C-MRSI in an integrated whole-body PET/MRI hybrid scanner is evaluated using phantom experiments. Methods: Combined PET and 13C...

  12. Value of PET and PET-CT in the management of lymphoma

    International Nuclear Information System (INIS)

    Positron emission tomography (PET) using 18F-fluorodeoxyglucose (FDG) is now widely used for staging and monitoring treatment results in patients with Hodgkin's disease (HD) and non-Hodgkin's lymphoma (NHL). Together, HD and NHL comprise only 8% of all malignancies, but most patients are young and potentially curable. In contrast to many solid tumors, lymphomas are highly sensitive to chemotherapy or radiotherapy and substantial long-term cure-rates of 90% for HD and 50% for aggressive NHL are expected with the current treatment options. However, the magnitude of late treatment-related morbidity and mortality especially in young HD patients treated with combination chemo-radiotherapy as well as the fact that still a considerable amount of NHL patients cannot be cured with standard induction therapy, has tempered the initial enthusiasm. Accordingly, tailoring the intensity of the treatment to individual patient basis has become very important. There are 3 principal domains to optimize the management of lymphoma patients in which FDG-PET has potential advantages: improving the accuracy of initial staging, early and more accurate assessment of response to treatment and finally optimizing the follow-up after therapy. In this lecture, the value of PET in these different areas is discussed. Several studies have investigated the role of FDG-PET for the initial staging of lymphoma. The majority of the studies compared the performances of PET with other imaging modalities. Studies were often retrospective and included a mix of NHL and HD without separate analysis for both subgroups. Another drawback is the missing of a true gold standard since discordant findings were rarely histological confirmed. In a recent meta-analysis [1] which included 20 studies, the pooled sensitivity was 90.9% and the pooled false-positive rate was 10.3%. Most reports focused on the comparison of PET with CT. PET was found to be more sensitive in both the detection of nodal (e.g. small sized nodes

  13. Evaluation of Dixon Sequence on Hybrid PET/MR Compared with Contrast-Enhanced PET/CT for PET-Positive Lesions

    Energy Technology Data Exchange (ETDEWEB)

    Jeong, Ju Hye; Cho, Ihn Ho; Kong, Eun Jung; Chun, Kyung Ah [Yeungnam Univ. Hospital, Daegu (Korea, Republic of)

    2014-03-15

    Hybrid positron emission tomography and magnetic resonance (PET/MR) imaging performs a two-point Dixon MR sequence for attenuation correction. However, MR data in hybrid PET/MR should provide anatomic and morphologic information as well as an attenuation map. We evaluated the Dixon sequence of hybrid PET/MR for anatomic correlation of PET-positive lesions compared with contrast-enhanced PET/computed tomography (CT) in patients with oncologic diseases. Twelve patients underwent a single injection, dual imaging protocol. PET/CT was performed with an intravenous contrast agent (85±13 min after {sup 18}F-FDG injection of 403± 45 MBq) and then (125±19 min after injection) PET/MR was performed. Attenuation correction and anatomic allocation of PET were performed using contrast-enhanced CT for PET/CT and Dixon MR sequence for hybrid PET/MR. The Dixon MR sequence and contrast-enhanced CT were compared for anatomic correlation of PET-positive lesions (scoring scale ranging from 0 to 3 for visual ratings). Additionally, standardized uptake values (SUVs) for the detected lesions were assessed for quantitative comparison. Both hybrid PET/MR and contrast-enhanced PET/CT identified 55 lesions with increased FDG uptake in ten patients. In total, 28 lymph nodes, 11 bone lesions, 3 dermal nodules, 3 pleural thickening lesions, 2 thyroid nodules, 1 pancreas, 1 liver, 1 ovary, 1 uterus, 1 breast, 1 soft tissue and 2 lung lesions were present. The best performance was observed for anatomic correlation of PET findings by the contrast-enhanced CT scans (contrast-enhanced CT, 2.64± 0.70; in-phase, 1.29±1.01; opposed-phase, 1.29±1.15; water-weighted, 1.71±1.07; fat weighted, 0.56±1.03). A significant difference was observed between the scores obtained from the contrast-enhanced CT and all four coregistered Dixon MR images. Quantitative evaluation revealed a high correlation between the SUVs measured with hybrid PET/MR (SUVmean, 2.63±1.62; SUVmax, 4.30±2.88) and contrast

  14. Measurement of Eccentricity of the Centre of Mass from the Geometric Centre of a Sphere

    Institute of Scientific and Technical Information of China (English)

    郭俊起; 胡忠坤; 顾邦明; 罗俊

    2004-01-01

    The eccentricity of the centre of mass from the geometric centre of a spherical attracting mass in determining the Newtonian gravitational constant G is tested by means of an electronic balance. The experimental result shows that the eccentricity of the sample is about 0.31 μm with uncertainty of 0.05 μm. Two density distribution models are discussed to estimate the uncertainty to G by the eccentricities of the attracting masses.

  15. 浅析奥斯汀的"performatives"发展及对翻译学的影响%On Austin's "performatives" and Its Influence on Translation Studies

    Institute of Scientific and Technical Information of China (English)

    任士明

    2006-01-01

    作为言语行为的最重要的奠基人之一,奥斯汀(Austin)从最初提出"constatives"与"performatives"的区别到最终放弃两者的区别,并把所有话语(utterances)归入"performatives".本文在探究这种转变的同时,进一步追溯"performatives"的来源,为"performatives"在国内译法进行正名,概述舍尔(Searle)对"performatives"的发展以及罗伯逊(Robinson)利用"performatives"理论在翻译领域的研究.因此,笔者在探讨中发现了该理论的应用价值及其对翻译学的影响.

  16. Development of PET in Latin America. Experience of the first PET-Cyclotron Center

    International Nuclear Information System (INIS)

    Aim: Describe the experience of the first PET-Cyclotron Center in Latin America. Demonstrate the viability of running a PET Center in Argentina despite the economic crisis. Materials and Methods: For this study, we used a UGM/GE Quest 250 PET scan, a RDS 112 cyclotron and a Radiosynthesis Laboratory installed at the (FUESMEN) Nuclear Medicine School Foundation, located in Mendoza City, in the middle-west of Argentina. From January 1999 to March 2002, 741 studies were obtained, 731 were 18FluorDeoxyGlucose-PET studies and 10 phantoms for calibration purposes. We used acquisition and imaging processing standard protocols, as well as research protocols designed according to the pathology under investigation. To better correlate anatomical and functional images, we used fusion techniques with (CT) Computed Tomography in some (WB) whole-body PET scans. Results: A total of 731 patients were retrospectively analyzed and classified according to statistics variables such as: 1-sex: 317 women and 414 men, 2-type of scan: 439 WB cases, 267 brain studies and 25 cardiac. From this data we divided them as PET indications and resulted in 17 cases as healthy volunteers, 422 oncological cases, 267 neurological studies and 25 cardiac for myocardial viability. According to the origin they were classified as patients coming from Mendoza 544, Buenos Aires 112, other argentine provinces 60 and foreign (Chile, Brazil and Uruguay) 15 cases. In terms of billing, 181 studies were done free of charge, 95 under research protocols were also done free of charge and 451 were charged. Conclusion: Not only the economical and political factors play an important role limiting the advances of PET Imaging in Latin America, but also the lack of a neighboring cyclotron that circumscribe many hospitals to have access to the radiopharmaceutical agent. FUESMEN was established in 1991 by three governmental entities: the (CONEA) National Commission of Atomic Energy, the (UNC) National University of Cuyo and

  17. Effects of unstratified and centre-stratified randomization in multi-centre clinical trials.

    Science.gov (United States)

    Anisimov, Vladimir V

    2011-01-01

    This paper deals with the analysis of randomization effects in multi-centre clinical trials. The two randomization schemes most often used in clinical trials are considered: unstratified and centre-stratified block-permuted randomization. The prediction of the number of patients randomized to different treatment arms in different regions during the recruitment period accounting for the stochastic nature of the recruitment and effects of multiple centres is investigated. A new analytic approach using a Poisson-gamma patient recruitment model (patients arrive at different centres according to Poisson processes with rates sampled from a gamma distributed population) and its further extensions is proposed. Closed-form expressions for corresponding distributions of the predicted number of the patients randomized in different regions are derived. In the case of two treatments, the properties of the total imbalance in the number of patients on treatment arms caused by using centre-stratified randomization are investigated and for a large number of centres a normal approximation of imbalance is proved. The impact of imbalance on the power of the study is considered. It is shown that the loss of statistical power is practically negligible and can be compensated by a minor increase in sample size. The influence of patient dropout is also investigated. The impact of randomization on predicted drug supply overage is discussed.

  18. Versatile coordination chemistry of a bis(methyliminophosphoranyl)pyridine ligand on copper centres.

    Science.gov (United States)

    Cheisson, Thibault; Auffrant, Audrey

    2014-09-21

    The coordination of a bis(methyliminophosphoranyl)pyridine ligand (L) to copper centres was studied. The use of copper(I) bromide precursors gave access to [LCuBr] (2) in which only one iminophosphorane arm is coordinated to the metal, as observed by X-ray crystallography and MAS (31)P NMR. Its fluxional behaviour in solution was demonstrated by VT-(31)P NMR, and investigated by DFT calculations. On the other hand, coordination of L to [Cu(CH3CN)4]PF6 gave a dimer [L2Cu2](PF6)2 (3) in which the two copper centres do not have the same coordination sphere as shown by X-ray crystallography. Addition of a strong ligand such as PEt3 allows the preparation of a cationic monomeric copper complex (4) in which L has a behaviour similar to that observed for 2. Synthesis of copper(II) complexes was also achieved by chemical oxidation of 2, which shows an irreversible oxidation at -0.36 vs. Fc(+)/Fc, or directly via the coordination of L to CuBr2. In [LCuBr2] (5), L adopts a pincer coordination. Finally, the catalytic behaviour of copper(I) complexes 2 and 3 was investigated in cyclopropanation reactions and [3 + 2] cycloadditions. PMID:25076168

  19. It's all change at the Computer Centre

    CERN Multimedia

    Laëtitia Pedroso

    2011-01-01

    The IT and EN Departments are modernising the infrastructure of the Computer Centre to improve the conditions in which the equipment has to operate and to increase capacity. The construction work has already begun and is due to be completed in October 2012.   Every year CERN experiences around ten power cuts lasting from less than a second to several hours. In most cases the two protection systems - the UPS* and the diesel generators – are able to ensure that the operation of the Computer Centre is not affected. As Vincent Doré, the project leader for the IT Department, and Paul Pepinster, the EN Department's technical coordinator in charge of modernising the infrastructure, explains: "Building 513 has two types of computing facilities – the "non-critical" ones, such as the servers for "off-line" computing, which have UPS systems ensuring that they can operate for 10 minutes after a power cut, and the "critical&...

  20. JOB CENTRE FOR DOMESTIC STAFF IN SWITZERLAND

    CERN Multimedia

    Relations with the Host States Service; http://www.cern.ch/relations/

    2001-01-01

    The Permanent mission of Switzerland to the International Organisations in Geneva has informed CERN that the Geneva Welcome Centre has set up an employment registration desk for the domestic staff of international civil servants. The aim of this pilot project is, on the one hand, to help international civil servants find domestic staff and, on the other hand, to help domestic staff holding an 'F'-type carte de légitimation find employment within 30 days after the expiry of a contract. For more information, please contact the Geneva Welcome Centre, La Pastorale, 106, route de Ferney, Case postale 103, 1211 Genève 20, tel. (+41.22) 918 02 70, fax (+41.22) 918 02 79), http://geneva-international.org/Welcome.E.html.