Sample records for aurothioglucose

  1. Cell-bound gold (CBG) in patients treated with aurothioglucose and with auranofin. A comparison of different methods of determination. (United States)

    van Riel, P L; Gribnau, F W; van de Putte, L B


    Three different methods of determining the cell-bound gold concentration were compared in patients given intramuscular and oral chrysotherapy for rheumatoid arthritis. We found a strong correlation between the different methods and no difference between 2 washing procedures.

  2. Radiosynovectomy of the knee joint in chronic arthritis; An easy and useful treatment. Radiosynoviectomie van de knie bij chronische artritis; Een eenvoudige en zinvolle behandeling

    Energy Technology Data Exchange (ETDEWEB)

    Boerbooms, A.M.T.; Putte, L.B.A. van de (Academisch Ziekenhuis St. Radboud, Nijmegen (Nteherlands). Afdeling Reumatologie); Corstens, F.H.M.; Buijs, W.C.A.M. (Academisch Ziekenhuis St. Radboud, Nijmegen (Netherlands). Afdeling Nucleaire Geneeskunde); Bruyn, G.A.W. (Medisch Centrum, Leeuwarden (Netherlands). Afdeling Reumatologie)


    185 MBq (5 mCi) colloidal 198-aurothioglucose ({sup 198}Au) or colloidal yttrium-90-silicate ({sup 90}Y) in 10 ml 0.9% NaCl was injected into knee joint cavity after aspiration of joint fluid. After that the patient stayed in bed for 3 days. Clinical examination, erythrocyte sedimentation rate, {sup 99m}Tc-pertechnetate uptake measurements and radiographs of the knee joints were performed at baseline and during follow-up. Main results, group 1. evaluation after 6 months and after 3 years showed significantly better results in the group of knee joints with no minimal pre-existing radiological abnormalities compared with the group of knee joints with moderate or severe radiological abnormalities (p<0.05). Group 2. 24 months (mean) after treatment with {sup 90}Y, 50% of the treated knees showed clinical improvement of the synovitis. Group 3. a significant reduction of haemarthrotic episodes of all 6 joints treated and a reduction of pain in 4 during a follow-up of 2.5 years.It is concluded that radiosynovectomy is a valuable and simple form of treatment for therapy-resistant chronic synovitis. (author). 20 refs.; 3 tabs.

  3. Do thyroid hormones function in insects? (United States)

    Davey, K G


    Earlier work demonstrated that phenoxy-phenyl compounds such as fenoxycarb and thyroxine mimicked the effects of JH III in causing a reduction in volume of the follicle cells of Locusta migratoria. While these compounds were only moderately effective, a derivative of thyroxine, 3,3',5-triiodothyronine (T3) was as effective as JH III, and T3 has been shown to bind to the same membrane receptor and activate the same pathway as JH III. The current paper shows that other thyroxine derivatives vary in activity. 3,3', 5'-Triiodothyronine (reverse T3) is inactive. 3,5-Diiodothyronine (T2) is more active than JH III, while its relatives (iodines at 3', 5' or at 3,3') are inactive. When follicles are exposed in vitro to rhodamine conjugated T3, the fluorescent compound can be seen to enter the cells and accumulate there: this process is inhibited by cycloheximide or by a temperature of 0 degrees C. The accumulation is antagonised by JH III but not JH I (which does not bind to the JH III membrane receptor) and by an antiserum raised against the putative membrane receptor protein. The action of T3, but not T2, is inhibited by 6-n-propyl-2-thiouracil or by aurothioglucose, both known to inhibit deiodinases. The activity of T3, but not of T2, increases with time of exposure to the follicle cells. These facts suggest that T3 enters the cells by receptor mediated endocytosis and is converted to a more active compound. Immunoreactivity to T3, but not thyroxine, can be detected in the haemolymph of locusts, and the titre varies slightly with the gonotrophic cycle. The food shows immunoreactivity for both thyroxine and T3. These findings suggest that thyroid hormones are ingested by locusts and have the potential to be used as hormonal signals in the control of egg production.