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Sample records for aurora facility

  1. Aurora final report

    Energy Technology Data Exchange (ETDEWEB)

    Robert, Dross; Amedeo, Conti

    2013-12-06

    Final Technical report detailing the work done by Nuvera and its partners to fulfill the goals of the program "Transport Studies Enabling Efficiency Optimization of Cost-Competitive Fuel Cell Stacks" (a.k.a. AURORA)

  2. The dynamic aurora

    International Nuclear Information System (INIS)

    Auroral physicists today know that auroras are lights emitted when atoms and molecules in the ionosphere are struck by electrons blowing in from the sun. The apparent motion of the auroral curtain is caused not by atmospheric turbulence but by changes in the electromagnetic conditions that propel the electrons, just as motion on a television screen is an illusion created by changes in the magnetic field that directs electrons from a cathode tube onto the screen. In the case of the aurora, what serves as the cathode tube? Where is its power supply? Why does that power seem to fluctuate from time to time, causing the aurora to ebb and flow across the polar sky? More than 20 years ago it was determined that auroral emissions occur because the ionosphere is bombarded by electron beams generated by a complex interaction between the solar wind and the earth's magnetic envelope. The geomagnetic nature of the aurora can be seen clearly from outer space. Centered on each of the geomagnetic poles is a great luminous oval that is a permanent feature of the planet. The one around the North Pole is the aurora borealis. Its counterpart in the south is the aurora australis. The authors and his colleagues have now found a numerical relation between the solar wind and the generation of the power that drives the aurora, as well as other disturbances of the geomagnetic field. They are also gaining a better idea of how the sun's activity affects the solar wind. This progress raises the interesting possibility of developing a computer method to predict the intensity of auroral activity. Because auroras can interfere significantly with radio and satellite communications, as well as with power lines and some defense systems, the ability to predict auroral intensity has become increasingly important as human activity expands into polar regions and into space

  3. Structure of black aurora associated with pulsating aurora

    Science.gov (United States)

    Fritz, Bruce A.; Lessard, Marc L.; Blandin, Matthew J.; Fernandes, Philip A.

    2015-11-01

    Morphological behavior of black aurora as it relates to pulsating aurora is investigated by examining a collection of ground-based observations from January 2007 in support of the Rocket Observations of Pulsating Aurora rocket campaign. Images were sampled from video recorded by a Xybion intensified camera (30 fps) at Poker Flat Research Range, AK. The primary observations of black aurora recorded during the substorm recovery phase were between separate patches of pulsating aurora as well as pulsating aurora separated from diffuse aurora. In these observations the black aurora forms an apparent firm boundary between the auroral forms in a new behavior that is in contrast with previously reported observations. Also presented for the first time are black curls in conjunction with pulsating aurora. Curl structures that indicate shear plasma flows in the ionosphere may be used as a proxy for converging/diverging electric fields in and above the ionosphere. This new subset of black auroral behavior may provide visual evidence of black aurora as an ionospheric feedback mechanism as related to pulsating aurora.

  4. Aurora laser optical system

    International Nuclear Information System (INIS)

    The Los Alamos National Laboratory KrF Aurora laser optical system is described. Conceptual, first-order, and detailed designs are presented for the major 248-nm ultraviolet optical, subsystems. In Aurora, a 5-ns front-end pulse is replicated and time encoded into a 96-beam, 480-ns pulse train, angle encoded, amplified, and then time and angle decoded so that all the 5-ns pulses arrive at the target plane simultaneously. The encoder and the centered optical system that directs the pulse train through the amplifiers have been installed, on major alignment system has been built and tested, and most decoder optical components have been designed and ordered. The plan is to have the entire optical system installed and initial integration completed by October 1987

  5. Baxter Aurora dialysis system.

    Science.gov (United States)

    Kelly, Thomas D

    2004-01-01

    With the recent focus on the benefits of more frequent dialysis, the Baxter Aurora dialysis system provides maximum flexibility for therapy prescription, including short daily treatments, long nocturnal treatments, hemodialysis, hemofiltration, and online hemodiafiltration, all in a compact, reliable, easy to use system. A self-prompting touch screen user interface mounted on a movable arm provides for comfortable operation, whether sitting and standing. An automatic treatment setup mode facilitates easy treatment setup. Complex menus are eliminated by the use of a hardware key that automatically selects only the prescribed options during power up, eliminating all menus associated with nonprescribed functions and modalities. This prevents the user from becoming confused or accidentally altering the dialysis treatment. Prior to dialysis the instrument goes through an automatic self-test that confirms the operation of internal systems. The screen will dim when there is no action that the patient needs to attend to on the instrument. After dialysis, press the disinfect button and the instrument disinfects itself and shuts off. For patient safety, the "disinfect" menus are not available during dialysis. The instrument can also be programmed to automatically start and rinse at a set time. For remote treatment monitoring, the instrument connects to the Internet. The Aurora records information about the machine's technical status, providing a record of instrument history for easy servicing. The Aurora is a flexible platform that provides the desired renal therapy with ease of use and proper support for the hemodialysis patient when combined with Baxter's 24-hour infrastructure and support. PMID:15043620

  6. Aurora laser optical system

    International Nuclear Information System (INIS)

    Aurora is the Los Alamos short-pulse high-power krypton fluoride laser system. It is primarily an end-to-end technology demonstration prototype for large-scale UV laser systems of interest for short-wavelength inertial confinement fusion (ICF) investigations. The system is designed to employ optical angular multiplexing and aerial amplification by electron-beam-driven KrF laser amplifiers to deliver to ICF targets a stack of pulses with a duration of 5 ns containing several kilojoules at a wavelength of 248 nm. A program of high-energy density plasma physics investigations is now planned, and a sophisticated target chamber was constructed. The authors describe the design of the optical system for Aurora and report its status. This optical system was designed and is being constructed in two phases. The first phase carries only through the amplifier train and does not include a target chamber or any demultiplexing. Installation should be complete, and some performance results should be available. The second phase provides demultiplexing and carries the laser light to target. The complete design is reported

  7. Aurorae in Australian Aboriginal Traditions

    CERN Document Server

    Hamacher, Duane W

    2013-01-01

    Transient celestial phenomena feature prominently in the astronomical knowledge and traditions of Aboriginal Australians. In this paper, I collect accounts of the Aurora Australis from the literature regarding Aboriginal culture. Using previous studies of meteors, eclipses, and comets in Aboriginal traditions, I anticipate that the physical properties of aurora, such as their generally red colour as seen from southern Australia, will be associated with fire, death, blood, and evil spirits. The survey reveals this to be the case and also explores historical auroral events in Aboriginal cultures, aurorae in rock art, and briefly compares Aboriginal auroral traditions with other global indigenous groups, including the Maori of New Zealand.

  8. Aurorae in Australian Aboriginal Traditions

    Science.gov (United States)

    Hamacher, Duane W.

    2013-07-01

    Transient celestial phenomena feature prominently in the astronomical knowledge and traditions of Aboriginal Australians. In this paper, I collect accounts of the Aurora Australis from the literature regarding Aboriginal culture. Using previous studies of meteors, eclipses, and comets in Aboriginal traditions, I anticipate that the physical properties of aurora, such as their generally red colour as seen from southern Australia, will be associated with fire, death, blood, and evil spirits. The survey reveals this to be the case and also explores historical auroral events in Aboriginal cultures, aurorae in rock art, and briefly compares Aboriginal auroral traditions with other global indigenous groups, including the Maori of New Zealand.

  9. Aurora status and plans

    International Nuclear Information System (INIS)

    Aurora is a short wavelength (248 nm) 10 to kJ KrF laser systems in the ICF program at Los Alamos National Laboratory. It is both an experiment in driver technology and a means for studying target performance using KrF laser light. Both features will be used to help evaluate the uv excimer laser as a viable fusion driver. The system has been designed to employ several electron-beam pumped amplifiers in series, with a final aperture of one meter square, to amplify 96 angularly mulitplexed 5 ns beamlets to the 10 kJ level. In Phase I, 48 of these beamlets are brought to target by demultiplexing and focusing with f26 optics. The beamlet ensemble, contained within an f1.9 bundle, is focused as a single beam;however, pointing is done individually. Spot size in the target plane is variable from 0.1-4 mm, with maximum averaged intensity of /similar to/ 4 x 1015 Wcm2. The illumination geometry is designed specifically for several classes of important target physics experiments. These include: energy flow, symmetry and preheat studies related to indirectly driven targets;x-ray conversion and plasma coupling characterization on disc targets, and hydrodynamic instability studies in planar geometry. System integration is proceeding toward initial target experiments in /similar to/ late 1988. Ninety-six beam amplification through the penultimate amplifier has been obtained at the sub-kJ level. Installation of beam train optics is proceeding, and the target system vacuum envelope is in place. 18 refs., 12 figs., 2 tabs

  10. Triton torus and Neptune aurora

    Science.gov (United States)

    Cheng, Andrew F.

    1990-01-01

    Triton is shown to be the dominant source of plasma for L equal to or greater than 7 in the magnetosphere of Neptune. Triton maintains a neutral hydrogen torus of average density comparable to a greater than that of the Titan torus at Saturn. The Triton torus may be detectable in H Lyman-alpha emissions. However, the energy source from plasma outward transport and mass loading in the Triton torus is insufficient to explain the Neptune aurora. It is proposed that Neptune's aurora is driven mainly by a solar wind interaction.

  11. Artificial Aurora Generated by HAARP (Invited)

    Science.gov (United States)

    Streltsov, A. V.; Kendall, E. A.

    2013-12-01

    We present results from the ionospheric heating experiment conducted on March 12, 2013 at the High Frequency Active Auroral Research Program (HAARP) facility in Alaska. During the experiment HAARP transmitted X-mode 4.57 MHz waves modulated with the frequency 0.9 mHz and pointed in the direction of the magnetic zenith. The beam was focused to ~20 km spot at the altitude 100 km. The heating produces two effects: First, it generates magnetic field-aligned currents producing D and H components of the magnetic field with frequency 0.9 mHz detected by fluxgate magnetometer in Gakona. Second, the heating produced bright luminous structures in the heated region detected with the SRI telescope in 427.8 nm, 557.7 nm, 630.0 nm wavelengths. We emphasize, that for the best of our knowledge, this is the first experiment where the heating of the ionosphere with X-mode produces luminous structures in the ionosphere. We classify this luminosity as an 'artificial aurora', because it correlate with the intensity of the magnetic field-aligned currents, and such correlation is constantly seen in the natural aurora.

  12. Image analysis of dayside aurora

    International Nuclear Information System (INIS)

    Ground based observations from Svalbard of the midday aurora by all sky cameras and meridian scanning photometers showed the sporadic occurrence of discrete auroral forms within or near the stable cusp or cleft aurora. Some of these forms appeared near the equatorward boundary of the stable cusp/cleft aurora and moved westward and northward. The duration of the whole event was typically less than 10 minutes. Series of such events were observed when the cusp/cleft was located at low latitudes. Satellite measurements of magnetic field and ion drift components above auroral strucures gave detailed information of auroral electrodynamics in the cusp/cleft ionosphere. Satellite observations of the dayside oval at ∼ 09 MLT showed that auroral emissions can be separated in different latitudinal zones with corresponding structures in the particle precipitation. The ground based optical instruments at Svalbard measured the stationary cleft aurora produced by soft electrons and transient discrete arcs produced by precipitating keV electrons. 89 refs

  13. Ionospheric Response to Flickering Aurora

    Science.gov (United States)

    Gustavsson, B.; Grydeland, T.; Blixt, M.; Baddeley, L.; Lunde, J.

    2007-12-01

    Flickering aurora is characterized by optical emissions varying in intensity with frequencies typically between 5 and 20 Hz. Here we use high-speed narrow field-of-view imaging in white light to determine the intensity variation in the field aligned direction, which is also the direction of the beam of the EISCAT Svalbard Radar (ESR). Incoherent scatter radar data is noise-like, and must be integrated over multiple pulses to reduce the variance to useful levels, even for high signal to noise ratios. Usually, this means integrating over several seconds to some tens of seconds of observation, which is not very useful with respect to flickering aurora. In the experiment presented here, we have taken data at the voltage level, before any integration. By integrating pulses with the same relative phase with respect to the optical intensity we can determine the variation in radar back-scatter on time-scales of 0.02 s.

  14. Periodisme i literatura: Aurora Bertrana

    Directory of Open Access Journals (Sweden)

    Neus Real

    2014-06-01

    Full Text Available This article relates the activity in the press of the writer Aurora Bertrana with her literature, and it makes evident the interdependence of journalism and literary creation in the first stage of the author’s production. It also analyzes the key role of this interaction in the construction of her image as well as in the consolidation of her intellectual prestige.

  15. Hydrogeology baseline study Aurora Mine

    International Nuclear Information System (INIS)

    A baseline hydrogeologic study was conducted in the area of Syncrude's proposed Aurora Mine in order to develop a conceptual regional hydrogeologic model for the area that could be used to understand groundwater flow conditions. Geologic information was obtained from over 2,000 coreholes and from data obtained between 1980 and 1996 regarding water level for the basal aquifer. A 3-D numerical groundwater flow model was developed to provide quantitative estimates of the potential environmental impacts of the proposed mining operations on the groundwater flow system. The information was presented in the context of a regional study area which encompassed much of the Athabasca Oil Sands Region, and a local study area which was defined by the lowlands of the Muskeg River Basin. Characteristics of the topography, hydrology, climate, geology, and hydrogeology of the region are described. The conclusion is that groundwater flow in the aquifer occurs mostly in a westerly direction beneath the Aurora Mine towards its inferred discharge location along the Athabasca River. Baseflow in the Muskeg River is mostly related to discharge from shallow surficial aquifers. Water in the river under baseflow conditions was fresh, of calcium-carbonate type, with very little indication of mineralization associated with deeper groundwater in the Aurora Mine area. 44 refs., 5 tabs., 31 figs

  16. Planetary protection in the framework of the Aurora exploration program

    Science.gov (United States)

    Kminek, G.

    The Aurora Exploration Program will give ESA new responsibilities in the field of planetary protection. Until now, ESA had only limited exposure to planetary protection from its own missions. With the proposed ExoMars and MSR missions, however, ESA will enter the realm of the highest planetary protection categories. As a consequence, the Aurora Exploration Program has initiated a number of activities in the field of planetary protection. The first and most important step was to establish a Planetary Protection Working Group (PPWG) that is advising the Exploration Program Advisory Committee (EPAC) on all matters concerning planetary protection. The main task of the PPWG is to provide recommendations regarding: Planetary protection for robotic missions to Mars; Planetary protection for a potential human mission to Mars; Review/evaluate standards & procedures for planetary protection; Identify research needs in the field of planetary protection. As a result of the PPWG deliberations, a number of activities have been initiated: Evaluation of the Microbial Diversity in SC Facilities; Working paper on legal issues of planetary protection and astrobiology; Feasibility study on a Mars Sample Return Containment Facility; Research activities on sterilization procedures; Training course on planetary protection (May, 2004); Workshop on sterilization techniques (fall 2004). In parallel to the PPWG, the Aurora Exploration Program has established an Ethical Working Group (EWG). This working group will address ethical issues related to astrobiology, planetary protection, and manned interplanetary missions. The recommendations of the working groups and the results of the R&D activities form the basis for defining planetary protection specification for Aurora mission studies, and for proposing modification and new inputs to the COSPAR planetary protection policy. Close cooperation and free exchange of relevant information with the NASA planetary protection program is strongly

  17. Recent laser experiments on the Aurora KrF/ICF laser system

    International Nuclear Information System (INIS)

    The Aurora KrF/ICF Laser Facility at Los Alamos is operational at the kilojoule-level for both laser and target experiments. We report on recent laser experiments on the system and resulting system improvements. 3 refs., 4 figs

  18. Evaluation of the Aurora Application Shade Measurement Accuracy

    Energy Technology Data Exchange (ETDEWEB)

    2015-12-01

    Aurora is an integrated, Web-based application that helps solar installers perform sales, engineering design, and financial analysis. One of Aurora's key features is its high-resolution remote shading analysis.

  19. Recent developments in pulsating aurora studies

    International Nuclear Information System (INIS)

    The field of pulsating aurora studies is reviewed. The paper begins with a short description of the characteristics of pulsating auroras and the theoretical ideas which, in view of existing experimental results, seem most important. A selection of new theoretical results and experimental results from both ground based instruments and instruments on rockets and satellites is then presented. There is now convincing evidence that the luminosity modulation is caused by a modulated flux of electron. The electron flux modulation seems to arise from a modulated resonant interaction between electrons and whistler mode waves in the equatorial plane, but the reason for the modulation is not known. Measurements concerning the drift and location of patches and the creation of Pi1 micropulsations are also deiscussed. Finally some suggestions for future research work are outlined. Optical measurements, especially with low light level TV, have proven to be of great importance in experimental studies of pulsating auroras. (author)

  20. Discovery of diffuse aurora on Mars.

    Science.gov (United States)

    Schneider, N M; Deighan, J I; Jain, S K; Stiepen, A; Stewart, A I F; Larson, D; Mitchell, D L; Mazelle, C; Lee, C O; Lillis, R J; Evans, J S; Brain, D; Stevens, M H; McClintock, W E; Chaffin, M S; Crismani, M; Holsclaw, G M; Lefevre, F; Lo, D Y; Clarke, J T; Montmessin, F; Jakosky, B M

    2015-11-01

    Planetary auroras reveal the complex interplay between an atmosphere and the surrounding plasma environment. We report the discovery of low-altitude, diffuse auroras spanning much of Mars' northern hemisphere, coincident with a solar energetic particle outburst. The Imaging Ultraviolet Spectrograph, a remote sensing instrument on the Mars Atmosphere and Volatile Evolution (MAVEN) spacecraft, detected auroral emission in virtually all nightside observations for ~5 days, spanning nearly all geographic longitudes. Emission extended down to ~60 kilometer (km) altitude (1 microbar), deeper than confirmed at any other planet. Solar energetic particles were observed up to 200 kilo--electron volts; these particles are capable of penetrating down to the 60 km altitude. Given minimal magnetic fields over most of the planet, Mars is likely to exhibit auroras more globally than Earth. PMID:26542577

  1. Elevated Aurora Kinase A Protein Expression in Diabetic Skin Tissue

    Science.gov (United States)

    Cho, Moon Kyun; An, Je Min; Kang, Sang Gue

    2014-01-01

    Background Aurora kinase A (Aurora-A) plays an important role in the regulation of mitosis and cytokinesis. Dysregulated Aurora-A leads to mitotic faults and results in pathological conditions. No studies on Aurora-A expression in human diabetic skin tissue have been reported. In light of this, we explored the expression of Aurora-A in human diabetic skin tissue. Methods Aurora-A protein was evaluated by western blotting in 6 human diabetic skin tissue and 6 normal skin specimens. Results Increased expression of Aurora-A protein was detected in all diabetic skin tissue samples in both western blot analysis and immunohistochemical staining. However, in the case of the normal skin tissue, no bands of Aurora-A protein were detected in either the western blotting analysis or the immunohistochemical staining. Conclusions Thus far, there have been no studies on the expression of Aurora-A in diabetic skin tissue. However, we believe that oxidative DNA damage related to the expression of Aurora-A protein and Aurora-A could be involved inhuman diabetic skin tissue. PMID:24511492

  2. Horse-collar aurora: A frequent pattern of the aurora in quiet times

    International Nuclear Information System (INIS)

    Reported here are DE 1 auroral imager observations of an auroral configuration which is given the name ''horse-collar aurora.'' The horse-collar pattern comprises the total area of auroral emissions from a single hemisphere and derives its name from the shape of the emitting area. The pattern is found in images recorded during quiet geomagnetic conditions and is possibly related to the theta aurora, another quiet time configuration of the auroras. This initial report of the DE 1 observations illustrates the horse-collar aurora with a 2-hour images sequence that displays its basic features and shows an example of its evolution into a theta-like auroral pattern. The interplanetary magnetic field was northward during this image sequence and there is some evidence for IMF B/sub y/ influence of the temporal development of the horse-collar pattern. A preliminary statistical analysis found the horse-collar pattern appearing in one-third or more of image sequences recorded during quiet conditions; it did not appear during disturbed conditions. Further study is required to establish more fully the characteristics of the horse-collar aurora and to determine its implications concerning solar wind-magnetosphere coupling when the IMF B/sub z/ is northward. copyright American Geophysical Union 1989

  3. Aurora A's functions during mitotic exit: the Guess Who game

    Directory of Open Access Journals (Sweden)

    David eReboutier

    2015-12-01

    Full Text Available Until recently, the knowledge of Aurora A kinase functions during mitosis was limited to pre-metaphase events, particularly centrosome maturation, G2/M transition, and mitotic spindle assembly. However, an involvement of Aurora A in post-metaphase events was also suspected, but not clearly demonstrated due to the technical difficulty to perform the appropriate experiments. Recent developments of both an analog specific version of Aurora A, and of small molecule inhibitors have led to the first demonstration that Aurora A is required for the early steps of cytokinesis. As in pre-metaphase, Aurora A plays diverse functions during anaphase, essentially participating in astral microtubules dynamics and central spindle assembly and functioning. The present review describes the experimental systems used to decipher new functions of Aurora A during late mitosis and situate these functions into the context of cytokinesis mechanisms.

  4. Aurora A's Functions During Mitotic Exit: The Guess Who Game.

    Science.gov (United States)

    Reboutier, David; Benaud, Christelle; Prigent, Claude

    2015-01-01

    Until recently, the knowledge of Aurora A kinase functions during mitosis was limited to pre-metaphase events, particularly centrosome maturation, G2/M transition, and mitotic spindle assembly. However, an involvement of Aurora A in post-metaphase events was also suspected, but not clearly demonstrated due to the technical difficulty to perform the appropriate experiments. Recent developments of both an analog-specific version of Aurora A and small molecule inhibitors have led to the first demonstration that Aurora A is required for the early steps of cytokinesis. As in pre-metaphase, Aurora A plays diverse functions during anaphase, essentially participating in astral microtubules dynamics and central spindle assembly and functioning. The present review describes the experimental systems used to decipher new functions of Aurora A during late mitosis and situate these functions into the context of cytokinesis mechanisms. PMID:26734572

  5. Jung's quest for the Aurora consurgens.

    Science.gov (United States)

    Haaning, Aksel

    2014-02-01

    The paper focuses on the year 1929 when Jung published 'A European commentary' to Richard Wilhelm's German translation of the Taoist text The Secret of the Golden Flower. This shows that Jung had already started on the track of European alchemy by following up Conrad Waldkirch's preface in Artis Auriferae (1593); and it raises the question of whether this could be the possible missing link to Jung's subsequent research in Alchemy and Hermetic Philosophy in the years to come. It is argued that here was the beginning of Jung's quest for the Aurora consurgens, the publication of which concludes the Mysterium Conuinctionis more than twenty years later. It is further maintained that this choice of the Aurora is a profound expression of Jung's ambition to revitalize the past from within the individual, and helps explain Jung's deep concern with the welfare and future of modern society. PMID:24467350

  6. Aurora Mine project - historical resources baseline study

    International Nuclear Information System (INIS)

    This volume contains the results of a base line archaeological study of the Aurora Mine Project local study area. It was compiled in support of Syncrude Canada's application to the Alberta Energy and Utilities Board (AEUB) and Alberta Environmental Protection to construct and operate it new Aurora Mine, located northeast of Fort McMurray, Alberta. The objective of this study was to compile, consolidate, review and analyze the reports for the area compiled over the past 22 years in and adjacent to the local study area (LSA), particularly those of now existing and Syncrude projects, and previously proposed Alsands and OSLO projects. The report is a summary of the human history in the area including pre-contact native archaeological sites, past archaeological studies, the Hinterland site pattern, post-contact native traditional sites, oil sands exploration/development related sites and paleontological sites in the subject area, and areas adjacent to it. 150 refs., 5 tabs., 43 figs

  7. Evolutionary Reconstruction and Population Genetics Analysis of Aurora Kinases

    OpenAIRE

    Balu Kamaraj; Ambuj Kumar; Rituraj Purohit

    2013-01-01

    BACKGROUND: Aurora kinases belong to the highly conserved kinase family and play a vital role in cell cycle regulation. The structure and function of these kinases are inter-related and sometimes they also act as substitutes in case of knockdown of other aurora kinases. METHOD: In this work we carried out the evolutionary reconstruction and population genetic studies of aurora kinase proteins. Substitution saturation test, CAI (Codon adaptation index), gene expression and RSCU (Relative synon...

  8. Aurora kinase inhibitors: Progress towards the clinic

    Czech Academy of Sciences Publication Activity Database

    Kollareddy, M.; Zheleva, D.; Dzubak, P.; Brahmkshatriya, Pathik; Lepšík, Martin; Hajduch, M.

    2012-01-01

    Roč. 30, č. 6 (2012), s. 2411-2432. ISSN 0167-6997 Grant ostatní: GA ČR(CZ) GA301/08/1649; GA ČR(CZ) GD303/09/H048 Institutional research plan: CEZ:AV0Z40550506 Keywords : Aurora kinases * cancer * inhibitors Subject RIV: CF - Physical ; Theoretical Chemistry Impact factor: 3.498, year: 2012

  9. Viking observations above a postnoon aurora

    International Nuclear Information System (INIS)

    This is the first paper that combines observations of the electric and magnetic fields, particles, wave emissions and UV images taken at intermediate altitude (two Earth radii) above the acceleration region of a 14 MLT aurora. The observations were made by the Swedish Viking satellite. The aurora appeared in the region of large-scale reversal of the perpendicular electric field. Strong fluctuations in the electric and magnetic field indicated that the aurora consisted of many arcs of varying latitudinal extent. Spin-averaged data show that an upward current sheet was connected with the observed UV aurora, with an ionospheric current density of 4 μA/m2 in the center of the sheet and 7 μA/m2 near the equatorward edge. The field-aligned potential drop Vparallel was determined from the mean energy of the upward ion beams and the width of the electron loss cone. Vparallel increased from several hundred volts near the equatorward edge of the current sheet to at least 3 kV in the center. Auroral kilometric radiation (AKR) and the widened electron loss cone indicated that the top of the acceleration region wwith Vparallel ≥ 3 kV was located near one Earth radius. The critical field-aligned potential drop, Vparallelc, which is strong enough to accelerate the bulk of the electrons into the loss cone, was derived from the characteristic electron energy T and the ratio of the magnetic field in the ionosphere to taht at the top of the acceleration region, Bi/Bv. The source plasma parameters were typical for magnetosheath plasma with a characteristic electron energy of about 200 eV

  10. Polar Embedding for Aurora Image Retrieval.

    Science.gov (United States)

    Yang, Xi; Gao, Xinbo; Tian, Qi

    2015-11-01

    Exploring the multimedia techniques to assist scientists for their research is an interesting and meaningful topic. In this paper, we focus on the large-scale aurora image retrieval by leveraging the bag-of-visual words (BoVW) framework. To refine the unsuitable representation and improve the retrieval performance, the BoVW model is modified by embedding the polar information. The superiority of the proposed polar embedding method lies in two aspects. On the one hand, the polar meshing scheme is conducted to determine the interest points, which is more suitable for images captured by circular fisheye lens. Especially for the aurora image, the extracted polar scale-invariant feature transform (polar-SIFT) feature can also reflect the geomagnetic longitude and latitude, and thus facilitates the further data analysis. On the other hand, a binary polar deep local binary pattern (polar-DLBP) descriptor is proposed to enhance the discriminative power of visual words. Together with the 64-bit polar-SIFT code obtained via Hamming embedding, the multifeature index is performed to reduce the impact of false positive matches. Extensive experiments are conducted on the large-scale aurora image data set. The experimental result indicates that the proposed method improves the retrieval accuracy significantly with acceptable efficiency and memory cost. In addition, the effectiveness of the polar-SIFT scheme and polar-DLBP integration are separately demonstrated. PMID:26068312

  11. Dayside aurorae and their relation to other geophysical phenomena

    International Nuclear Information System (INIS)

    Principal morphological peculiarities of auroral luminosity are investigated on the basis of the data from multi-year aurorae observations in day hours at Spitzbergen and Franz Jozef Land. It is shown that in this region the typical forms of aurorae are moving poleward rayed arcs appearing at the equatorward boundary of the auroral oval and disappearing at its pole boundary. Discrete forms of aurorae are located inside a much broader red luminosity band in its equatorward part. Auroral pulsations with a period of 10 50 s are observed in the prenoon sector in a region of much harder precipitations found more equatorward with respect to the daytime red luminosity band. The influence of a Bz IMF component upon daytime aurorae is exercised both directly through an equatorward (poleward) shift of daytime aurorae upon decreasing (increasing) Bz and via an increase in planetary geomagnetic activity related to the appearance of substorms during which the whole region of the daytime luminosity is shifted to much lower latitudes. A decrease of intensity of daytime aurorae with duration of 5-10 min before the beginning of an expansive phase of a substorm on the night side is detected. The peculiarities of the daytime aurorae dynamics during substorms are also investigated. A scheme of the daytime auroral luminosity distribution is presented. Analytical expressions of the dependence of the daytime aurorae position on IMF are provided. Certain physical mechanisms that can explain the peculiarities of daytime aurorae dynamics are also discussed. (Author)

  12. Evolutionary reconstruction and population genetics analysis of aurora kinases.

    Directory of Open Access Journals (Sweden)

    Balu Kamaraj

    Full Text Available BACKGROUND: Aurora kinases belong to the highly conserved kinase family and play a vital role in cell cycle regulation. The structure and function of these kinases are inter-related and sometimes they also act as substitutes in case of knockdown of other aurora kinases. METHOD: In this work we carried out the evolutionary reconstruction and population genetic studies of aurora kinase proteins. Substitution saturation test, CAI (Codon adaptation index, gene expression and RSCU (Relative synonymous codon usage values were computed for all the three aurora kinases. Linear regression method was used to check the dependency of gene expression on their CAI values. RESULTS: The results suggested that aurora-B and aurora-C has shown convergence in their evolutionary pathway. Moreover, the aurora-A I57V mutation showed high penetrance in human population and exist at very high frequency (84.4% when compared to the native residue (15.6%. The mutation showed notable range of functional gain and seemed to be promising for the evolution of aurora-A function. Mutant allele might also become a challenging prospect for understanding the pattern of evolution followed by cell cycle kinases. CONCLUSION: The overall result suggested that the aurora-A is currently under the evolutionary transition and to determine the functional significance of the mutation further investigation are required.

  13. The effect of the impact of comet Shoemaker Levy-9 on Jupiter's aurorae

    Science.gov (United States)

    Miller, S.; Achilleos, N.; Dinelli, B. M.; Lam, H. A.; Tennyson, J.; Jagod, M.-F.; Geballe, T. R.; Trafton, L. M.; Joseph, R. D.; Ballester, G. E.; Baines, K.; Brooke, T. Y.; Orton, G.

    We present infrared spectra and images of the jovian aurorae taken at wavelengths sensitive to the H3+ molecular ion during the period around the impact of Comet Shoemaker Levy-9. The spectra were obtained using CGS4 on the United Kingdom Infrared Telescope and the images using NSFcam on NASA's Infrared Telescope Facility. Comparison with spectra obtained in May, 1993, shows that while the relative intensities of the northern and southern auroral zones prior to and during impact week (July 16-22, 1994) were broadly comparable with those of 1993, a few days after the last collision the northern aurora was considerably enhanced and its southern counterpart somewhat depressed. The north/south auroral ratio was returning to more normal values a week later. The effect of material drifting from the impact sites to the southern auroral zone is discussed in relation to these results.

  14. Solar activity around AD 775 from aurorae and radiocarbon

    CERN Document Server

    Neuhaeuser, Ralph

    2015-01-01

    A large variation in 14 C around AD 775 has been considered to be caused by one or more solar super-flares within one year. We critically review all known aurora reports from Europe as well as the Near, Middle, and Far East from AD 731 to 825 and find 39 likely true aurorae plus four more potential aurorae and 24 other reports about halos, meteors, thunderstorms etc., which were previously misinterpreted as aurorae or misdated; we assign probabilities for all events according to five aurora criteria. We find very likely true aurorae in AD 743, 745, 762, 765, 772, 773, 793, 796, 807, and 817. There were two aurorae in the early 770s observed near Amida (now Diyarbakir in Turkey near the Turkish-Syrian border), which were not only red, but also green-yellow - being at a relatively low geo-magnetic latidude, they indicate a relatively strong solar storm. However, it cannot be argued that those aurorae (geo-magnetical latitude 43 to 50 deg, considering five different reconstructions of the geo-magnetic pole) coul...

  15. Jung's quest for the "Aurora consurgens"

    DEFF Research Database (Denmark)

    Haaning, Aksel

    2014-01-01

    Auriferae (1593); and it raises the question of whether this could be the possible missing link to Jung's subsequent research in Alchemy and Hermetic Philosophy in the years to come. It is argued that here was the beginning of Jung's quest for the Aurora consurgens, the publication of which concludes the......The paper focuses on the year 1929 when Jung published ‘A European commentary’ to Richard Wilhelm's German translation of the Taoist text The Secret of the Golden Flower. This shows that Jung had already started on the track of European alchemy by following up Conrad Waldkirch's preface in Artis...

  16. Observation of O+ (4P-4D0 lines in electron aurora over Svalbard

    Directory of Open Access Journals (Sweden)

    K. Throp

    2004-09-01

    Full Text Available This work reports on observations of O+ lines in aurora over Svalbard, Norway. The Spectrographic Imaging Facility measures auroral spectra in three wavelength intervals (Hβ, N+2 1N(0,2 and N+2 1N(1,3. The oxygen ion multiplet (4639-4696Å is blended with the band. It is found that in electron aurora, the brightness of this multiplet, is on average, about 0.1 of the total brightness. A joint optical and incoherent scatter radar study of an electron aurora event shows that the ratio is enhanced when the ionisation in the upper E-layer (140-190km is significant with respect to the E-layer peak below 130km. Rayed arcs were observed on one such occasion, whereas on other occasions the auroral intensity was below the threshold of the imager. A one-dimensional electron transport model is used to estimate the cross section for production of the multiplet in electron collisions, yielding 0.18x10-18cm2.

  17. High-speed stereoscopy of aurora

    Science.gov (United States)

    Kataoka, R.; Fukuda, Y.; Uchida, H. A.; Yamada, H.; Miyoshi, Y.; Ebihara, Y.; Dahlgren, H.; Hampton, D.

    2016-01-01

    We performed 100 fps stereoscopic imaging of aurora for the first time. Two identical sCMOS cameras equipped with narrow field-of-view lenses (15° by 15°) were directed at magnetic zenith with the north-south base distance of 8.1 km. Here we show the best example that a rapidly pulsating diffuse patch and a streaming discrete arc were observed at the same time with different parallaxes, and the emission altitudes were estimated as 85-95 km and > 100 km, respectively. The estimated emission altitudes are consistent with those estimated in previous studies, and it is suggested that high-speed stereoscopy is useful to directly measure the emission altitudes of various types of rapidly varying aurora. It is also found that variation of emission altitude is gradual (e.g., 10 km increase over 5 s) for pulsating patches and is fast (e.g., 10 km increase within 0.5 s) for streaming arcs.

  18. Jovian-like aurorae on Saturn.

    Science.gov (United States)

    Stallard, Tom; Miller, Steve; Melin, Henrik; Lystrup, Makenzie; Cowley, Stan W H; Bunce, Emma J; Achilleos, Nicholas; Dougherty, Michele

    2008-06-19

    Planetary aurorae are formed by energetic charged particles streaming along the planet's magnetic field lines into the upper atmosphere from the surrounding space environment. Earth's main auroral oval is formed through interactions with the solar wind, whereas that at Jupiter is formed through interactions with plasma from the moon Io inside its magnetic field (although other processes form aurorae at both planets). At Saturn, only the main auroral oval has previously been observed and there remains much debate over its origin. Here we report the discovery of a secondary oval at Saturn that is approximately 25 per cent as bright as the main oval, and we show this to be caused by interaction with the middle magnetosphere around the planet. This is a weak equivalent of Jupiter's main oval, its relative dimness being due to the lack of as large a source of ions as Jupiter's volcanic moon Io. This result suggests that differences seen in the auroral emissions from Saturn and Jupiter are due to scaling differences in the conditions at each of these two planets, whereas the underlying formation processes are the same. PMID:18563160

  19. Saturn's aurora observed by the Cassini camera at visible wavelengths

    CERN Document Server

    Dyudina, Ulyana A; Ewald, Shawn P; Wellington, Danika

    2015-01-01

    The first observations of Saturn's visible-wavelength aurora were made by the Cassini camera. The aurora was observed between 2006 and 2013 in the northern and southern hemispheres. The color of the aurora changes from pink at a few hundred km above the horizon to purple at 1000-1500 km above the horizon. The spectrum observed in 9 filters spanning wavelengths from 250 nm to 1000 nm has a prominent H-alpha line and roughly agrees with laboratory simulated auroras. Auroras in both hemispheres vary dramatically with longitude. Auroras form bright arcs between 70 and 80 degree latitude north and between 65 and 80 degree latitude south, which sometimes spiral around the pole, and sometimes form double arcs. A large 10,000-km-scale longitudinal brightness structure persists for more than 100 hours. This structure rotates approximately together with Saturn. On top of the large steady structure, the auroras brighten suddenly on the timescales of a few minutes. These brightenings repeat with a period of about 1 hour....

  20. Preclinical validation of Aurora kinases-targeting drugs in osteosarcoma

    OpenAIRE

    Tavanti, E; Sero, V; Vella, S; M. Fanelli; Michelacci, F; Landuzzi, L; Magagnoli, G; Versteeg, R; Picci, P; Hattinger, C M; M. Serra

    2013-01-01

    Background: Aurora kinases are key regulators of cell cycle and represent new promising therapeutic targets in several human tumours. Methods: Biological relevance of Aurora kinase-A and -B was assessed on osteosarcoma clinical samples and by silencing these genes with specific siRNA in three human osteosarcoma cell lines. In vitro efficacy of two Aurora kinases-targeting drugs (VX-680 and ZM447439) was evaluated on a panel of four drug-sensitive and six drug-resistant human osteosarcoma cell...

  1. TPX2 Protein of Arabidopsis Activates Aurora Kinase 1, But Not Aurora Kinase 3 In Vitro

    Czech Academy of Sciences Publication Activity Database

    Tomaštíková, Eva; Demidov, D.; Jeřábková, Hana; Binarová, Pavla; Houben, A.; Doležel, Jaroslav; Petrovská, Beáta

    2015-01-01

    Roč. 33, č. 6 (2015), s. 1988-1995. ISSN 0735-9640 R&D Projects: GA ČR(CZ) GA14-28443S; GA MŠk(CZ) LO1204; GA ČR GAP501/12/2333 Institutional support: RVO:61389030 ; RVO:61388971 Keywords : Aurora kinase * Targeting protein for Xklp2 * In vitro kinase assay Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 1.656, year: 2014

  2. Were Greek temples oriented towards aurorae?

    Science.gov (United States)

    Liritzis, Ioannis; Vassiliou, Helen

    2006-02-01

    Two ancient Greek temples of Apollo at Bassae (Phigaleia, western Peloponnese, Greece), and Thermon at Aetolia, (Aetoloacarnania, western central Greece), have a north-south orientation of their main entrances. This is a rather rare alignment of temples in general and specifically of Apollo in classical Greece, where most of them have broadly an east-west orientation. Based on historical and mythological accounts, as well as astronomical orientation measurements, the northern direction orientation of these constructions may relate to the rare, albeit impressive, occurrence of aurorae borealis, the northern lights. These strong lights are attributed to god Apollo by the epithet ``hyperborean'', meaning to the northern lands. Attribution is supported by archaeomagnetic directional data accompanied by auroral occurrence during those times.

  3. Global magnetic anomaly and aurora of Neptune

    Science.gov (United States)

    Cheng, Andrew F.

    1990-01-01

    The large offset and tilt of Neptune's dipole magnetic field combine to create a global magnetic anomaly, analogous to but much more important than earth's South Atlantic Anomaly. Energetic particle precipitation loss within the Neptune anomaly creates 'atmospheric drift shadows' within which particle fluxes are greatly reduced. The energetic particle dropout observed by Voyager near closest approach occurred near the predicted times when Voyager passed within the atmospheric drift shadow. Extremely soft, structured bursts of ions and electrons within the drift shadow may result from plasma wave-induced pitch angle scattering of trapped particles confined near the magnetic equator. The dropout does not necessarily imply that Voyager passed through an earth-like discrete auroral zone, as earlier reported. The ion and electron fluxes observed within the dropout period correspond to particles that must precipitate to Neptune's atmosphere within the anomaly region. This anomaly precipitation can account for a major portion of the ultraviolet emissions previously identified as Neptune aurora.

  4. SPICAM observations and modeling of Mars aurorae

    Science.gov (United States)

    Soret, Lauriane; Gérard, Jean-Claude; Libert, Ludivine; Shematovich, Valery I.; Bisikalo, Dmitry V.; Stiepen, Arnaud; Bertaux, Jean-Loup

    2016-01-01

    Martian aurorae have been detected with the SPICAM instrument on board Mars Express both in the nadir and the limb viewing modes. In this study, we focus on three limb observations to determine both the altitudes and the intensities of the auroral emissions. The CO (a3Π-X1Σ) Cameron bands between 190 and 270 nm, the CO (A1Π-X1Σ+) Fourth Positive system (CO 4P) between 135 and 170 nm, the CO2+ (B2Σu+-X2Πg) doublet at 289 nm, the OI at 297.2 nm and the 130.4 nm OI triplet emissions have been identified in the spectra and in the time variations of the signals. The intensities of these auroral emissions have been quantified and the altitude of the strongest emission of the CO Cameron bands has been estimated to be 137 ± 27 km. The locations of these auroral events have also been determined and correspond to the statistical boundary of open-closed magnetic field lines, in cusp-like structures. The observed altitudes of the auroral emissions are reproduced by a Monte-Carlo model of electron transport in the Martian thermosphere for mono-energetic electrons between 40 and 200 eV. No correlation between electron fluxes measured in the upper thermosphere and nadir auroral intensity has been found. Here, we simulate auroral emissions observed both at the limb and at the nadir using electron energy spectra simultaneously measured with the ASPERA-3/ELS instrument. The simulated altitudes are in very good agreement with the observations. We find that predicted vertically integrated intensities for the various auroral emissions are overestimated, probably as a consequence of the inclination and curvature of the magnetic field line threading the aurora. However, the relative brightness of the CO and CO2+ emissions is in good agreement with the observations.

  5. A new Director for the BAA Aurora Section

    Science.gov (United States)

    Gavine, D.

    2011-02-01

    from 2011 January 1, Dr Dave Gavine handed over the Aurora Section Directorship to Ken Kennedy, who has been Assistant Director for the last five years, with special responsibility for Noctilucent Clouds, currently the Section's most important work.

  6. Research Ship Aurora Australis Underway Meteorological Data, Quality Controlled

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Research Ship Aurora Australis Underway Meteorological Data (delayed ~10 days for quality control) are from the Shipboard Automated Meteorological and Oceanographic...

  7. Night trend in average brightness of aurora discrete forms

    International Nuclear Information System (INIS)

    Using the method of imposed epochs according to the data of visual observations for many years of aurorae at the Tixi and Norilsk stations, a systematic decrease in the average brightness of aurora discrete forms in diurnal course with the increase in time elapsed after the sunset at the altitude of 200 km above the station is detected. It is assumed that the tendency is caused by the change in electric conductivity of ionospheric link of auroral current systems

  8. Preservation of minimally processed 'aurora-1' peaches using additives

    OpenAIRE

    Ramilo Nogueira Martins; Ben-Hur Mattiuz; Leandra Oliveira Santos; Cristiane Maria Ascari Morgado; Claudia Fabrino Machado Mattiuz

    2011-01-01

    'Aurora-1' peaches establishes an interesting alternative as a minimally processed product, due to its characteristics like flavor, color, smell, and also because of its handling resistance. However, it has a short shelf life after a fresh-cut due to enzymatic browning and stone cavity collapse. The main purpose of this research was to test the additive with antioxidant effect to prevent browning in minimally processed 'Aurora-1' peaches. The minimal processing consists of washing, sanitizing...

  9. IK-guided PP2A suppresses Aurora B activity in the interphase of tumor cells.

    Science.gov (United States)

    Lee, Sunyi; Jeong, Ae Lee; Park, Jeong Su; Han, Sora; Jang, Chang-Young; Kim, Keun Il; Kim, Yonghwan; Park, Jong Hoon; Lim, Jong-Seok; Lee, Myung Sok; Yang, Young

    2016-09-01

    Aurora B activation is triggered at the mitotic entry and required for proper microtubule-kinetochore attachment at mitotic phase. Therefore, Aurora B should be in inactive form in interphase to prevent aberrant cell cycle progression. However, it is unclear how the inactivation of Aurora B is sustained during interphase. In this study, we find that IK depletion-induced mitotic arrest leads to G2 arrest by Aurora B inhibition, indicating that IK depletion enhances Aurora B activation before mitotic entry. IK binds to Aurora B, and colocalizes on the nuclear foci during interphase. Our data further show that IK inhibits Aurora B activation through recruiting PP2A into IK and Aurora B complex. It is thus believed that IK, as a scaffold protein, guides PP2A into Aurora B to suppress its activity in interphase until mitotic entry. PMID:26906715

  10. Solar activity around AD 775 from aurorae and radiocarbon

    Science.gov (United States)

    Neuhäuser, R.; Neuhäuser, D. L.

    2015-04-01

    A large variation in 14C around AD 775 has been considered to be caused by one or more solar super-flares within one year. We critically review all known aurora reports from Europe as well as the Near, Middle, and Far East from AD 731 to 825 and find 39 likely true aurorae plus four more potential aurorae and 24 other reports about halos, meteors, thunderstorms etc., which were previously misinterpreted as aurorae or misdated; we assign probabilities for all events according to five aurora criteria. We find very likely true aurorae in AD 743, 745, 762, 765, 772, 773, 793, 796, 807, and 817. There were two aurorae in the early 770s observed near Amida (now Diyarbak\\i r in Turkey near the Turkish-Syrian border), which were not only red, but also green-yellow - being at a relatively low geomagnetic latitude, they indicate a relatively strong solar storm. However, it cannot be argued that those aurorae (geomagnetic latitude 43 to 50°, considering five different reconstructions of the geomagnetic pole) could be connected to one or more solar super-flares causing the 14C increase around AD 775: There are several reports about low- to mid-latitude aurorae at 32 to 44° geomagnetic latitude in China and Iraq; some of them were likely observed (quasi-)simultaneously in two of three areas (Europe, Byzantium/Arabia, East Asia), one lasted several nights, and some indicate a particularly strong geomagnetic storm (red colour and dynamics), namely in AD 745, 762, 793, 807, and 817 - always without 14C peaks. We use 39 likely true aurorae as well as historic reports about sunspots together with the radiocarbon content from tree rings to reconstruct the solar activity: From AD {˜ 733} to {˜ 823}, we see at least nine Schwabe cycles; instead of one of those cycles, there could be two short, weak cycles - reflecting the rapid increase to a high 14C level since AD 775, which lies at the end of a strong cycle. In order to show the end of the dearth of naked-eye sunspots, we

  11. Sporadic aurorae observed in East Asia

    Directory of Open Access Journals (Sweden)

    D. M. Willis

    2007-03-01

    aurorae observed in the United States during the interval AD 1880–1940. The localised nature and spatial structure of some sporadic aurorae observed in East Asia is indicated by the use of descriptive terms such as "lightning", "rainbow", "streak" and "grid".

  12. Dancing Lights: Creating the Aurora Story

    Science.gov (United States)

    Wood, E. L.; Cobabe-Ammann, E. A.

    2009-12-01

    Science tells a story about our world, our existence, our history, and the larger environment our planet occupies. Bearing this in mind, we created a series of lessons for 3rd-5th grades using a cross-disciplinary approach to teaching about the aurora by incorporating stories, photos, movies, and geography into the science in order to paint a broad picture and answer the question, “why do we care?” The fundamental backbone of the program is literacy. Students write and illustrate fiction and non-fiction work, poetry, and brochures that solidify both language arts skills and science content. In a time when elementary teachers relegate science to less than one hour per week, we have developed a novel science program that can be easily integrated with other topics during the typical school day to increase the amount of science taught in a school year. We are inspiring students to take an interest in the natural world with this program, a stepping-stone for larger things.

  13. Aurora A drives early signalling and vesicle dynamics during T-cell activation

    Science.gov (United States)

    Blas-Rus, Noelia; Bustos-Morán, Eugenio; Pérez de Castro, Ignacio; de Cárcer, Guillermo; Borroto, Aldo; Camafeita, Emilio; Jorge, Inmaculada; Vázquez, Jesús; Alarcón, Balbino; Malumbres, Marcos; Martín-Cófreces, Noa B.; Sánchez-Madrid, Francisco

    2016-01-01

    Aurora A is a serine/threonine kinase that contributes to the progression of mitosis by inducing microtubule nucleation. Here we have identified an unexpected role for Aurora A kinase in antigen-driven T-cell activation. We find that Aurora A is phosphorylated at the immunological synapse (IS) during TCR-driven cell contact. Inhibition of Aurora A with pharmacological agents or genetic deletion in human or mouse T cells severely disrupts the dynamics of microtubules and CD3ζ-bearing vesicles at the IS. The absence of Aurora A activity also impairs the activation of early signalling molecules downstream of the TCR and the expression of IL-2, CD25 and CD69. Aurora A inhibition causes delocalized clustering of Lck at the IS and decreases phosphorylation levels of tyrosine kinase Lck, thus indicating Aurora A is required for maintaining Lck active. These findings implicate Aurora A in the propagation of the TCR activation signal. PMID:27091106

  14. Making Sense of the Aurora: A Research Project

    Directory of Open Access Journals (Sweden)

    Robert Marc Friedman

    2012-05-01

    Full Text Available The article provides an introduction to a on-going research project based at University of Tromsø that seeks to analyze the history of efforts to make sense of the aurora borealis from the early 1700s through to the Cold War. Following brilliant displays of the northern lights in the early eighteenth century, natural philosophers strove to explain this phenomenon that evoked widespread fear and superstition. It was not until well into the twentieth century that consensual explanation emerged for this, one of the great enigmas in the history of science. From the start, the quest to explain the aurora borealis became enmeshed with patriotic science and nationalist sentiments. The history of efforts to understand the nature and cause of the aurora poses a number of thematic problems. Being a fleeting and at times rapidly changing phenomenon, only occasionally seen south of far-northern latitudes, the aurora needed to be constituted as an object able to be brought into the domain of rational science. Observational accounts of the aurora came most often from by personsliving or travelling in the far north or in the Arctic, but these persons were generally not trained scientists: Whose witnessing counted and how was authority negotiated among professional scientists and amateurs?

  15. Aurora Borealis, A Painting by Frederic Edwin Church

    Science.gov (United States)

    Love, J. J.

    2015-12-01

    This year marks the sesquicentennial anniversary of the end of the American Civil War. In 1865, the same year as the War's end, the great American landscape artist, Frederic Edwin Church, unveiled Aurora Borealis, a painting that depicts a fantastic, far-northern place, an auroral arch stretched across a quiet night-time sky, above dark mountains and a frozen sea. Church was born in Connecticut, lived in New York, and traveled to Labrador; he would have often seen the northern lights. Church might have also been influenced by the spectacular displays of aurora that were caused by some unusually intense magnetic storms in 1859. Aurora Borealis can certainly be interpreted in terms of 19th-century romanticism, scientific philosophy, and Arctic missions of exploration, all subjects of interest to Church. As with so many of his paintings, Church's meticulous attention to detail in Aurora Borealis reveals his deep admiration of nature. But his depiction of auroral light is a curious and possibly intentional departure from natural verisimilitude. Some art historians have suggested that Church painted Aurora Borealis as a subdued tribute to the end of the Civil War, with the drapery of auroral light forming an abstract representation of the American flag. If so, then colors of the flag have been unfurled across a cold and barren landscape, not in extravagant celebration, but in somber recognition of the reality of post-war desolation and an uncertain future.

  16. A mathematical model of Aurora B activity in prophase and metaphase.

    Science.gov (United States)

    Doherty, Kevin; Meere, Martin; Piiroinen, Petri T

    2016-07-01

    Aurora B kinase is a protein that controls several processes in mitosis when it is found associated with INCENP, Survivin and Borealin in a complex known as the Chromosomal Passenger Complex. Aurora B in complex with INCENP is phosphorylated on three sites, resulting in the full activation of Aurora B. In prophase and metaphase, Aurora B is activated at centromeres, the region of chromatin linking sister chromatids, due to an autophosphorylation mechanism, and it has been hypothesised that Aurora B is activated throughout the cytoplasm due to its concentration at centromeres. In this article, we first develop a time-dependent model of Aurora B activation that does not incorporate spatial variation. This model is used to demonstrate the various qualitative behaviours that the activation of Aurora B is capable of displaying for different model parameters. Next, we develop a spatio-temporal model of Aurora B activation that includes diffusion of soluble Aurora B and binding of Aurora B to immobile centromeric binding sites. This model describes the activation of Aurora B throughout the cytoplasm due to its concentration-dependent activation at centromeres. The models demonstrate the effects that a soluble phosphatase concentration, multisite phosphorylation and diffusion have on the activation of Aurora B. PMID:27155569

  17. Optical tomography of the aurora and EISCAT

    Directory of Open Access Journals (Sweden)

    H. U. Frey

    Full Text Available Tomographic reconstruction of the three-dimensional auroral arc emission is used to obtain vertical and horizontal distributions of the optical auroral emission. Under the given experimental conditions with a very limited angular range and a small number of observers, algebraic reconstruction methods generally yield better results than transform techniques. Different algebraic reconstruction methods are tested with an auroral arc model and the best results are obtained with an iterative least-square method adapted from emission-computed tomography. The observation geometry used during a campaign in Norway in 1995 is tested with the arc model and root-mean-square errors, to be expected under the given geometrical conditions, are calculated. Although optimum geometry was not used, root-mean-square errors of less than 2% for the images and of the order of 30% for the distribution could be obtained. The method is applied to images from real observations. The correspondence of original pictures and projections of the reconstructed volume is discussed, and emission profiles along magnetic field lines through the three-dimensionally reconstructed arc are calibrated into electron density profiles with additional EISCAT measurements. Including a background profile and the temporal changes of the electron density due to recombination, good agreement can be obtained between measured profiles and the time-sequence of calculated profiles. These profiles are used to estimate the conductivity distribution in the vicinity of the EISCAT site. While the radar can only probe the ionosphere along the radar beam, the three-dimensional tomography enables conductivity estimates in a large area around the radar site.

    Key words. Tomography · Aurora · EISCAT · Ionosphere · Conductivity

  18. Ionospheric response to particle precipitation within aurora

    International Nuclear Information System (INIS)

    The aurora is just the visible signature of a large number of processes occurring in a planetary ionosphere as a response to energetic charged particles falling in from the near-empty space far above the planetary atmosphere. This thesis, based on measurements using the EISCAT incoherent scatter radar system in northern Scandinavia, discusses ionospheric response processes and especially a mechanism leading to atmospheric gas escape from a planet. One of the most spectacular events in the high latitude atmosphere on earth are the 'auroral arcs' - dynamic rayed sheets of light. An investigation of the conditions of the ionosphere surrounding auroral arcs shows that strong field-aligned bulk ion outflows appear in the topside ionosphere which account for a large fraction of the escape of atmospheric oxygen from earth. Four different additional ionospheric responses are closely related to this ion outflow; 1. enhanced electron temperatures of several thousand Kelvin above an altitude of about 250 km, 2. enhanced ionization around an altitude of 200 km corresponding to electron precipitation with energies of a few hundred eV, 3. the occurrence of naturally enhanced ion acoustic fluctuations seen in the radar spectrum, most likely produced by an ion-ion two-stream instability, and 4. upward directed field-aligned currents partly carried by the outflowing ions. From these observations, it is suggested that the energy dissipation into the background plasma through Joule heating, the production of a few hundred eV energetic run-away electrons, and strong ion outflows are partly produced by the simultaneous presence of ion acoustic turbulence and field-aligned currents above auroral arcs. (20 refs.) (au)

  19. Generation of ninety-six angularly multiplexed KrF beams at Aurora

    International Nuclear Information System (INIS)

    The Aurora KrF laser facility is designed to produce ninety-six laser beams at 248 nm with total energy of -- 10 kJ. The 5-ns duration beams are angularly multiplexed to allow sequential amplification in electron-beam-pumped amplifiers. These amplifiers operated over a half-microsecond period. Previous to this investigation, all individual components of the Aurora system have been operated independently. As a first step toward integration of the full system, the author operated the front end, beam slicer, small-aperture module (SAM), and angle encoder to generate ninety-six angularly multiplexed beams. These beams have been delivered to the first of the three large amplifiers, which will boost the pulse train energy from <1 J to 10 kJ. Measurements to date have concentrated on the total energy of the pulse train and pulse shapes of the individual beams at positions preceding and following SAM. Measured gain through SAM is -- 13 with 20 the target figure. Relative pulse heights are preserved through SAM with the exception of the first pulse of the 12

  20. The grand aurorae borealis seen in Colombia in 1859

    Science.gov (United States)

    Moreno Cárdenas, Freddy; Cristancho Sánchez, Sergio; Vargas Domínguez, Santiago

    2016-01-01

    On Thursday, September 1, 1859, the British astronomer Richard Carrington, for the first time ever, observes a spectacular gleam of visible light on the surface of the solar disk, the photosphere. The Carrington Event, as it is nowadays known by scientists, occurred because of the high solar activity that had visible consequences on Earth, in particular reports of outstanding aurorae activity that amazed thousands of people in the western hemisphere during the dawn of September 2. The geomagnetic storm, generated by the solar-terrestrial event, had such a magnitude that the auroral oval expanded towards the equator, allowing low latitudes, like Panama's 9°N, to catch a sight of the aurorae. An expedition was carried out to review several historical reports and books from the northern cities of Colombia allowed the identification of a narrative from Montería, Colombia (8° 45‧N), that describes phenomena resembling those of an aurorae borealis, such as fire-like lights, blazing and dazzling glares, and the appearance of an immense S-like shape in the sky. The very low latitude of the geomagnetic north pole in 1859, the lowest value in over half a millennia, is proposed to have allowed the observations of auroral events at locations closer to the equator, and supports the historical description found in Colombia. The finding of such chronicle represents one of the most complete descriptions of low-latitude sightings of aurorae caused by the Carrington Event.

  1. Breaking the Ice: Strategies for Future European Research in the Polar Oceans - The AURORA BOREALIS Concept

    Science.gov (United States)

    Lembke-Jene, L.; Biebow, N.; Wolff-Boenisch, B.; Thiede, J.; European Research Icebreaker Consortium

    2011-12-01

    Research vessels dedicated to work in polar ice-covered waters have only rarely been built. Their history began with Fritjof Nansen's FRAM, which he used for his famous first crossing of the Arctic Ocean 1893-1896. She served as example for the first generation of polar research vessels, at their time being modern instruments planned with foresight. Ice breaker technology has developed substantially since then. However, it took almost 80 years until this technical advance also reached polar research, when the Russian AKADEMIK FEDEROV, the German POLARSTERN, the Swedish ODEN and the USCG Cutter HEALY were built. All of these house modern laboratories, are ice-breakers capable to move into the deep-Arctic during the summer time and represent the second generation of dedicated polar research vessels. Still, the increasing demand in polar marine research capacities by societies that call for action to better understand climate change, especially in the high latitudes is not matched by adequate facilities and resources. Today, no icebreaker platform exists that is permanently available to the international science community for year-round expeditions into the central Arctic Ocean or heavily ice-infested waters of the polar Southern Ocean around Antarctica. The AURORA BOREALIS concept plans for a heavy research icebreaker, which will enable polar scientists around the world to launch international research expeditions into the central Arctic Ocean and the Antarctic continental shelf seas autonomously during all seasons of the year. The European Research Icebreaker Consortium - AURORA BOREALIS (ERICON-AB) was established in 2008 to plan the scientific, governance, financial, and legal frameworks needed for the construction and operation of this first multi-nationally owned and operated research icebreaker and polar scientific drilling platform. By collaborating together and sharing common infrastructures it is envisioned that European nations make a major contribution to

  2. Aurorasaurus: A citizen science platform for viewing and reporting the aurora

    Science.gov (United States)

    MacDonald, E. A.; Case, N. A.; Clayton, J. H.; Hall, M. K.; Heavner, M.; Lalone, N.; Patel, K. G.; Tapia, A.

    2015-09-01

    A new, citizen science-based, aurora observing and reporting platform has been developed with the primary aim of collecting auroral observations made by the general public to further improve the modeling of the aurora. In addition, the real-time ability of this platform facilitates the combination of citizen science observations with auroral oval models to improve auroral visibility nowcasting. Aurorasaurus provides easily understandable aurora information, basic gamification, and real-time location-based notification of verified aurora activity to engage citizen scientists. The Aurorasaurus project is one of only a handful of space weather citizen science projects and can provide useful results for the space weather and citizen science communities. Early results are promising with over 2000 registered users submitting over 1000 aurora observations and verifying over 1700 aurora sightings posted on Twitter.

  3. Drilling Polar Oceans with the European Research Icebreaker AURORA BOREALIS: the IODP Context

    Science.gov (United States)

    Lembke-Jene, Lester; Wolff-Boenisch, Bonnie; Azzolini, Roberto; Thiede, Joern; Biebow, Nicole; Eldholm, Olav; Egerton, Paul

    2010-05-01

    Polar oceans are characterized by extreme environmental conditions for humans and materials, and have remained the least accessible regions to scientists of the IODP. DSDP and ODP have for long faced specific technical and logistical problems when attempting to drill in ice-covered polar deep-sea basins. The Arctic Ocean and large areas of the high-latitude Southern Ocean remained largely un-sampled by ODP and remain one of the major scientific and technological challenges for IODP. Drilling in these regions has been discussed and anticipated for decades and the scientific rationales are reflected in the science plans of the international Nansen Arctic Drilling Program (NAD) or the Arctic Program Planning Group (APPG) of ODP/IODP, amongst others. More recently, the rationale to investigate the polar oceans in a holistic approach has been outlined by workshops, leading to strategic assessments of the scientific potential and new drilling proposals. The European Polar Board took the initiative to develop a plan for a novel and dedicated research icebreaker with technical capabilities hitherto unrealised. This research icebreaker will enable autonomous operations in the central Arctic Ocean and the Southern Ocean, even during the severest ice conditions in the deep winter, serving all marine disciplines of polar research including scientific drilling: The European Research Icebreaker and Deep-Sea Drilling Vessel AURORA BOREALIS. AURORA BOREALIS is presently planned as a multi-purpose vessel. The ship can be deployed as a research icebreaker in all polar waters during any season of the year, as it shall meet the specifications of the highest ice-class attainable (IACS Polar Code 1) for icebreakers. During the times when it is not employed for drilling, it will operate as the most technically advanced multi-disciplinary research vessel in the Arctic or polar Southern Ocean. AURORA BOREALIS will be a "European scientific flagship facility" (fully open to non

  4. Pulsating aurora induced by upper atmospheric barium releases

    Science.gov (United States)

    Deehr, C.; Romick, G.

    1977-01-01

    The paper reports the apparent generation of pulsating aurora by explosive releases of barium vapor near 250 km altitude. This effect occurred only when the explosions were in the path of precipitating electrons associated with the visible aurora. Each explosive charge was a standard 1.5 kg thermite mixture of Ba and CuO with an excess of Ba metal which was vaporized and dispersed by the thermite explosion. Traces of Sr, Na, and Li were added to some of the charges, and monitoring was achieved by ground-based spectrophotometric observations. On March 28, 1976, an increase in emission at 5577 A and at 4278 A was observed in association with the first two bursts, these emissions pulsating with roughly a 10 sec period for approximately 60 to 100 sec after the burst.

  5. MLN8054 and Alisertib (MLN8237): Discovery of Selective Oral Aurora A Inhibitors.

    Science.gov (United States)

    Sells, Todd B; Chau, Ryan; Ecsedy, Jeffrey A; Gershman, Rachel E; Hoar, Kara; Huck, Jessica; Janowick, David A; Kadambi, Vivek J; LeRoy, Patrick J; Stirling, Matthew; Stroud, Stephen G; Vos, Tricia J; Weatherhead, Gabriel S; Wysong, Deborah R; Zhang, Mengkun; Balani, Suresh K; Bolen, Joseph B; Manfredi, Mark G; Claiborne, Christopher F

    2015-06-11

    The Aurora kinases are essential for cell mitosis, and the dysregulation of Aurora A and B have been linked to the etiology of human cancers. Investigational agents MLN8054 (8) and alisertib (MLN8237, 10) have been identified as high affinity, selective, orally bioavailable inhibitors of Aurora A that have advanced into human clinical trials. Alisertib (10) is currently being evaluated in multiple Phase II and III clinical trials in hematological malignancies and solid tumors. PMID:26101564

  6. Sds22 regulates aurora B activity and microtubule–kinetochore interactions at mitosis

    OpenAIRE

    Posch, Markus; Khoudoli, Guennadi A.; Swift, Sam; King, Emma M.; DeLuca, Jennifer G.; Swedlow, Jason R.

    2010-01-01

    We have studied Sds22, a conserved regulator of protein phosphatase 1 (PP1) activity, and determined its role in modulating the activity of aurora B kinase and kinetochore–microtubule interactions. Sds22 is required for proper progression through mitosis and localization of PP1 to mitotic kinetochores. Depletion of Sds22 increases aurora B T-loop phosphorylation and the rate of recovery from monastrol arrest. Phospho–aurora B accumulates at kinetochores in Sds22-depleted cells juxtaposed to c...

  7. The Discovery of Aurora Kinase Inhibitor by Multi-Docking-Based Virtual Screening

    Directory of Open Access Journals (Sweden)

    Jun-Tae Kim

    2014-11-01

    Full Text Available We report the discovery of aurora kinase inhibitor using the fragment-based virtual screening by multi-docking strategy. Among a number of fragments collected from eMololecules, we found four fragment molecules showing potent activity (>50% at 100 μM against aurora kinase. Based on the explored fragment scaffold, we selected two compounds in our synthesized library and validated the biological activity against Aurora kinase.

  8. The Discovery of Aurora Kinase Inhibitor by Multi-Docking-Based Virtual Screening

    OpenAIRE

    Jun-Tae Kim; Seo Hee Jung; Sun Young Kang; Chung-Kyu Ryu; Nam Sook Kang

    2014-01-01

    We report the discovery of aurora kinase inhibitor using the fragment-based virtual screening by multi-docking strategy. Among a number of fragments collected from eMololecules, we found four fragment molecules showing potent activity (>50% at 100 μM) against aurora kinase. Based on the explored fragment scaffold, we selected two compounds in our synthesized library and validated the biological activity against Aurora kinase.

  9. Aurorae of Io and Europa: Observations and Modeling

    OpenAIRE

    Roth, Lorenz

    2012-01-01

    In the present dissertation we study the auroral emissions emanating from the tenuous atmospheres of Jupiter's satellites Io and Europa. The satellites are embedded in a dense magnetospheric plasma environment. Due to Jupiter's fast rotation the corotating magnetospheric plasma particles constantly flow past Io and Europa causing a complex interaction and triggering auroral emission in the atmospheres. Therefore, aurora observations are a useful tool to explore both the magnetospheric environ...

  10. Performance of the Aurora KrF ICF laser system

    International Nuclear Information System (INIS)

    Because short wavelength lasers are attractive for inertial confinement fusion (ICF), the Department of Energy is sponsoring work at Los Alamos National Laboratory in krypton-fluoride (KrF) laser technology. Aurora is a short-pulse, high-power, KrF laser system. It serves as an end-to-end technology demonstration prototype for large-scale ultraviolet laser systems for short wavelength ICF research. The system employs optical angular multiplexing and serial amplification by electron-beam-driven KrF laser amplifiers. The 1 to 5 ns pulse of the Aurora front end is split into 96 beams which are angularly and temporally multiplexed to produce a 480 ns pulse train for amplification by four KrF laser amplifiers. In the present system configuration half (48) of the amplified pulses are demultiplexed using different optical path lengths and delivered simultaneously to target. This paper discusses how the Aurora laser system has entered the initial operational phase by delivering pulse energies of greater than one kilojoule to target

  11. Doppler shifted H Ly α emission from Jupiter's aurora

    International Nuclear Information System (INIS)

    IUE observations of the aurora on Jupiter have been performed with high spectral resolution in a search for Doppler shifted H Ly α emission produced through charge exchange by fast precipitating protons, as observed in the Earth's aurora. No emission has been observed corresponding to proton energies greater than 200 eV, placing a strict upper limit on the contribution of KeV - MeV protons to the production of Jupiter's aurora. However, a large fraction of the H Ly α emission has appeared Doppler-shifted mainly toward the blue by roughly 50 km/sec, corresponding to a kinetic energy of 10-20 eV for a fast proton or H atom, and there are higher velocity wings on the line extending out to equivalent energies of 150-200 eV. The blue shift indicates motion up out of the atmosphere, and the authors suggest that the emission results from the in situ acceleration of ionospheric protons in Jupiter's auroral ionosphere by analogy to the ionospheric potentials observed in the Earth's auroral zones. These observations demonstrate that the acceleration of ionospheric plasma in an H2 atmosphere can lead to bright Ly α emission, with implications for the production of the outer planet airglow emissions

  12. The Grand Aurorae Borealis Seen in Colombia in 1859

    CERN Document Server

    Cárdenas, Freddy Moreno; Domínguez, Santiago Vargas

    2015-01-01

    On Thursday, September 1, 1859, the British astronomer Richard Carrington, for the first time ever, observes a spectacular gleam of visible light on the surface of the solar disk, the photosphere. The Carrington Event, as it is nowadays known by scientists, occurred because of the high solar activity that had visible consequences on Earth, in particular reports of outstanding aurorae activity that amazed thousands of people in the western hemisphere during the dawn of September 2. The geomagnetic storm, generated by the solar-terrestrial event, had such a magnitude that the auroral oval expanded towards the equator, allowing low latitudes, like Panama's 9$^\\circ$ N, to catch a sight of the aurorae. An expedition was carried out to review several historical reports and books from the northern cities of Colombia, allowing the identification of a narrative from Monter\\'ia, Colombia (8$^\\circ$ 45' N), that describes phenomena resembling those of an aurorae borealis, such as fire-like lights, blazing and dazzling ...

  13. Pulsating proton aurora caused by rising tone Pc1 waves

    Science.gov (United States)

    Nomura, R.; Shiokawa, K.; Omura, Y.; Ebihara, Y.; Miyoshi, Y.; Sakaguchi, K.; Otsuka, Y.; Connors, M.

    2016-02-01

    We found rising tone emissions with a dispersion of ˜1 Hz per several tens of seconds in the dynamic spectrum of a Pc1 geomagnetic pulsation (Pc1) observed on the ground. These Pc1 rising tones were successively observed over ˜30 min from 0250 UT on 14 October 2006 by an induction magnetometer at Athabasca, Canada (54.7°N, 246.7°E, magnetic latitude 61.7°N). Simultaneously, a Time History of Events and Macroscale Interactions during Substorms panchromatic (THEMIS) all-sky camera detected pulsations of an isolated proton aurora with a period of several tens of seconds, ˜10% variations in intensity, and fine structures of 3° in magnetic longitudes. The pulsations of the proton aurora close to the zenith of ATH have one-to-one correspondences with the Pc1 rising tones. This suggests that these rising tones scatter magnetospheric protons intermittently at the equatorial region. The radial motion of the magnetospheric source, of which the isolated proton aurora is a projection, can explain the central frequency increase of Pc1, but not the shorter period (tens of seconds) frequency increase of ˜1 Hz in Pc1 rising tones. We suggest that EMIC-triggered emissions generate the frequency increase of Pc1 rising tones on the ground and that they also cause the Pc1 pearl structure, which has a similar characteristic time.

  14. Evolutionary relationships of Aurora kinases: Implications for model organism studies and the development of anti-cancer drugs

    Directory of Open Access Journals (Sweden)

    Patrick Denis R

    2004-10-01

    Full Text Available Abstract Background As key regulators of mitotic chromosome segregation, the Aurora family of serine/threonine kinases play an important role in cell division. Abnormalities in Aurora kinases have been strongly linked with cancer, which has lead to the recent development of new classes of anti-cancer drugs that specifically target the ATP-binding domain of these kinases. From an evolutionary perspective, the species distribution of the Aurora kinase family is complex. Mammals uniquely have three Aurora kinases, Aurora-A, Aurora-B, and Aurora-C, while for other metazoans, including the frog, fruitfly and nematode, only Aurora-A and Aurora-B kinases are known. The fungi have a single Aurora-like homolog. Based on the tacit assumption of orthology to human counterparts, model organism studies have been central to the functional characterization of Aurora kinases. However, the ortholog and paralog relationships of these kinases across various species have not been rigorously examined. Here, we present comprehensive evolutionary analyses of the Aurora kinase family. Results Phylogenetic trees suggest that all three vertebrate Auroras evolved from a single urochordate ancestor. Specifically, Aurora-A is an orthologous lineage in cold-blooded vertebrates and mammals, while structurally similar Aurora-B and Aurora-C evolved more recently in mammals from a duplication of an ancestral Aurora-B/C gene found in cold-blooded vertebrates. All so-called Aurora-A and Aurora-B kinases of non-chordates are ancestral to the clade of chordate Auroras and, therefore, are not strictly orthologous to vertebrate counterparts. Comparisons of human Aurora-B and Aurora-C sequences to the resolved 3D structure of human Aurora-A lends further support to the evolutionary scenario that vertebrate Aurora-B and Aurora-C are closely related paralogs. Of the 26 residues lining the ATP-binding active site, only three were variant and all were specific to Aurora-A. Conclusions In

  15. AURORA on MEGSAT 1 a photon counting observatory for the Earth UV night-sky background and Aurora emission

    CERN Document Server

    Monfardini, A; Stalio, R; Mahne, N; Battiston, R; Menichelli, M; Mazzinghi, P

    2001-01-01

    A low-mass, low-cost photon-counting scientific payload has been developed and launched on a commercial microsatellite in order to study the near-UV night-sky background emission with a telescope nicknamed 'Notte' and the Aurora emission with 'Alba'. AURORA, this is the name of the experiment, will determine, with the 'Notte' channel, the overall night-side photon background in the 300-400 nm spectral range, together with a particular 2 sup + N sub 2 line (lambda sub c =337 nm). The 'Alba' channel, on the other hand, will study the Aurora emissions in four different spectral bands (FWHM=8.4-9.6 nm) centered on: 367 nm (continuum evaluation), 391 nm (1 sup - N sup + sub 2), 535 nm (continuum evaluation), 560 nm (OI). The instrument has been launched on the 26 September, 2000 from the Baikonur cosmodrome on a modified SS18 Dnepr-1 'Satan' rocket. The satellite orbit is nearly circular (h sub a sub p sub o sub g sub e sub e =648 km, e=0.0022), and the inclination of the orbital plane is 64.56 deg. An overview of...

  16. AURORA on MEGSAT 1: a photon counting observatory for the Earth UV night-sky background and Aurora emission

    International Nuclear Information System (INIS)

    A low-mass, low-cost photon-counting scientific payload has been developed and launched on a commercial microsatellite in order to study the near-UV night-sky background emission with a telescope nicknamed 'Notte' and the Aurora emission with 'Alba'. AURORA, this is the name of the experiment, will determine, with the 'Notte' channel, the overall night-side photon background in the 300-400 nm spectral range, together with a particular 2+N2 line (λc=337 nm). The 'Alba' channel, on the other hand, will study the Aurora emissions in four different spectral bands (FWHM=8.4-9.6 nm) centered on: 367 nm (continuum evaluation), 391 nm (1-N+2), 535 nm (continuum evaluation), 560 nm (OI). The instrument has been launched on the 26 September, 2000 from the Baikonur cosmodrome on a modified SS18 Dnepr-1 'Satan' rocket. The satellite orbit is nearly circular (hapogee=648 km, e=0.0022), and the inclination of the orbital plane is 64.56 deg. An overview of the techniques adopted is given in this paper

  17. AURORA on MEGSAT 1: a photon counting observatory for the Earth UV night-sky background and Aurora emission

    Energy Technology Data Exchange (ETDEWEB)

    Monfardini, A. E-mail: monfardi@sci.area.trieste.it; Trampus, P.; Stalio, R.; Mahne, N.; Battiston, R.; Menichelli, M.; Mazzinghi, P

    2001-08-21

    A low-mass, low-cost photon-counting scientific payload has been developed and launched on a commercial microsatellite in order to study the near-UV night-sky background emission with a telescope nicknamed 'Notte' and the Aurora emission with 'Alba'. AURORA, this is the name of the experiment, will determine, with the 'Notte' channel, the overall night-side photon background in the 300-400 nm spectral range, together with a particular 2{sup +}N{sub 2} line ({lambda}{sub c}=337 nm). The 'Alba' channel, on the other hand, will study the Aurora emissions in four different spectral bands (FWHM=8.4-9.6 nm) centered on: 367 nm (continuum evaluation), 391 nm (1{sup -}N{sup +}{sub 2}), 535 nm (continuum evaluation), 560 nm (OI). The instrument has been launched on the 26 September, 2000 from the Baikonur cosmodrome on a modified SS18 Dnepr-1 'Satan' rocket. The satellite orbit is nearly circular (h{sub apogee}=648 km, e=0.0022), and the inclination of the orbital plane is 64.56 deg. An overview of the techniques adopted is given in this paper.

  18. AURORA on MEGSAT 1: a photon counting observatory for the Earth UV night-sky background and Aurora emission

    Science.gov (United States)

    Monfardini, A.; Trampus, P.; Stalio, R.; Mahne, N.; Battiston, R.; Menichelli, M.; Mazzinghi, P.

    2001-08-01

    A low-mass, low-cost photon-counting scientific payload has been developed and launched on a commercial microsatellite in order to study the near-UV night-sky background emission with a telescope nicknamed ``Notte'' and the Aurora emission with ``Alba''. AURORA, this is the name of the experiment, will determine, with the ``Notte'' channel, the overall night-side photon background in the 300-400nm spectral range, together with a particular 2+N2 line (λc=337nm). The ``Alba'' channel, on the other hand, will study the Aurora emissions in four different spectral bands (FWHM=8.4-9.6nm) centered on: 367nm (continuum evaluation), 391nm (1-N+2), 535nm (continuum evaluation), 560nm (OI). The instrument has been launched on the 26 September, 2000 from the Baikonur cosmodrome on a modified SS18 Dnepr-1 ``Satan'' rocket. The satellite orbit is nearly circular (hapogee=648km, /e=0.0022), and the inclination of the orbital plane is 64.56°. An overview of the techniques adopted is given in this paper.

  19. STS-45 Earth observation of the Aurora Australis or Southern Lights

    Science.gov (United States)

    1992-01-01

    STS-45 Earth observation taken onboard Atlantis, Orbiter Vehicle (OV) 104, is of the Aurora Australis or Southern Lights. The STS-45 crewmembers note the interesting spiralling or corkscrew appearance of this particular sighting. Aurorae were observed and photographed throughout the STS-45 nine-day mission.

  20. Akt Inhibitor A-443654 Interferes with Mitotic Progression by Regulating Aurora A Kinase Expression

    Directory of Open Access Journals (Sweden)

    Xuesong Liu

    2008-08-01

    Full Text Available Both Akt and Aurora A kinase have been shown to be important targets for intervention for cancer therapy. We report here that Compound A (A-443654, a specific Akt inhibitor, interferes with mitotic progression and bipolar spindle formation. Compound A induces G2/M accumulation, defects in centrosome separation, and formation of either monopolar arrays or disorganized spindles. On the basis of gene expression array studies, we identified Aurora A as one of the genes regulated transcriptionally by Akt inhibitors including Compound A. Inhibition of the phosphatidylinositol 3-kinase (PI3K/Akt pathway, either by PI3K inhibitor LY294002 or by Compound A, dramatically inhibits the promoter activity of Aurora A, whereas the mammalian target of rapamycin inhibitor has little effect, suggesting that Akt might be responsible for up-regulating Aurora A for mitotic progression. Further analysis of the Aurora A promoter region indicates that the Ets element but not the Sp1 element is required for Compound A-sensitive transcriptional control of Aurora A. Overexpression of Aurora A in cells treated with Compound A attenuates the mitotic arrest and the defects in bipolar spindle formation induced by Akt inhibition. Our studies suggest that that Akt may promote mitotic progression through the transcriptional regulation of Aurora A.

  1. Spiral structures and regularities in magnetic field variations and auroras

    Science.gov (United States)

    Feldstein, Y. I.; Gromova, L. I.; Förster, M.; Levitin, A. E.

    2012-02-01

    The conception of spiral shaped precipitation regions, where solar corpuscles penetrate the upper atmosphere, was introduced into geophysics by C. Störmer and K. Birkeland at the beginning of the last century. Later, in the course of the XX-th century, spiral distributions were disclosed and studied in various geophysical phenomena. Most attention was devoted to spiral shapes in the analysis of regularities pertaining to the geomagnetic activity and auroras. We review the historical succession of perceptions about the number and positions of spiral shapes, that characterize the spatial-temporal distribution of magnetic disturbances. We describe the processes in the upper atmosphere, which are responsible for the appearance of spiral patterns. We considered the zones of maximal aurora frequency and of maximal particle precipitation intensity, as offered in the literature, in their connection with the spirals. We discuss the current system model, that is closely related to the spirals and that appears to be the source for geomagnetic field variations during magnetospheric substorms and storms. The currents in ionosphere and magnetosphere constitute together with field-aligned (along the geomagnetic field lines) currents (FACs) a common 3-D current system. At ionospheric heights, the westward and eastward electrojets represent characteristic elements of the current system. The westward electrojet covers the longitudinal range from the morning to the evening hours, while the eastward electrojet ranges from afternoon to near-midnight hours. The polar electrojet is positioned in the dayside sector at cusp latitudes. All these electrojets map along the magnetic field lines to certain plasma structures in the near-Earth space. The first spiral distribution of auroras was found based on observations in Antarctica for the nighttime-evening sector (N-spiral), and later in the nighttime-evening (N-spiral) and morning (M-spiral) sectors both in the Northern and Southern

  2. The dawn of Aurora kinase research: from fly genetics to the clinic.

    Directory of Open Access Journals (Sweden)

    Mar eCarmena

    2015-11-01

    Full Text Available Aurora kinases comprise a family of highly conserved serine-threonine protein kinases that play a pivotal role in the regulation of cell cycle. Aurora kinases are not only involved in the control of multiple processes during cell division but also coordinate chromosomal and cytoskeletal events, contributing to the regulation of checkpoints and ensuring the smooth progression of the cell cycle.Because of their fundamental contribution to cell cycle regulation, Aurora kinases were originally identified in independent genetic screens designed to find genes involved in the regulation of cell division. The first aurora mutant was part of a collection of mutants isolated in C. Nusslein-Volhard’s laboratory. This collection was screened in D. M. Glover’s laboratory in search for mutations disrupting the centrosome cycle in embryos derived from homozygous mutant mothers. The mutants identified were given names related to the polar regions, and included not only aurora but also the equally famous polo. Ipl1, the only Aurora in yeast, was identified in a genetic screen looking for mutations that caused chromosome segregation defects. The discovery of a second Aurora-like kinase in mammals opened a new chapter in the research of Aurora kinases. The rat kinase AIM was found to be highly homologous to the fly and yeast proteins, but localised at the midzone and midbody and was proposed to have a role in cytokinesis. Homologs of the equatorial Aurora (Aurora B were identified in metazoans ranging from flies to humans. Xenopus Aurora B was found to be in a complex with the chromosomal passenger INCENP, and both proteins were shown to be essential in flies for chromosome structure, segregation, central spindle formation and cytokinesis. Fifteen years on, Aurora kinase research is an active field of research. After the successful introduction of the first anti-mitotic agents in cancer therapy, both Auroras have become the focus of attention as targets for

  3. Model of the Crustal Magnetic Field in the Martian Aurora Zone

    Institute of Scientific and Technical Information of China (English)

    TONG Dong-Sheng; CHEN Chu-Xin

    2011-01-01

    It is well known that aurorae are prominent on planets with a global magnetic field and occur where open magnetic Geld lines converge. The UV spectrometer used for investigating the characteristics of the atmosphere of Mars (SPICAM) on board the Mars Express made the first observation of auroral-type emission in the cusp region of the strong crustal magnetic field on Mars and found that the arc of the Martian aurora zone is very narrow in width, which obviously differs from that of other planets. Based on the observation, we put forward a model of a crustal magnetic field on the Martian aurora zone through the morphology of Martian aurorae. In the model, equivalent currents are proposed; the topology and magnitude of the magnetic field generated by these equivalent currents are consistent with that of the crustal magnetic field in the Martian aurora zone. The morphology of the Martian aurora zone generated through the model matches well with the observations made by the Mars Express orbiter.%It is well known that aurorae are prominent on planets with a global magnetic field and occur where open magnetic field lines converge.The UV spectrometer used for investigating the characteristics of the atmosphere of Mars (SPICAM) on board the Mars Express made the first observation of auroral-type emission in the cusp region of the strong crustal magnetic field on Mars and found that the arc of the Martian aurora zone is very narrow in width,which obviously differs from that of other planets.Based on the observation,we put forward a model of a crustal magnetic field on the Martian aurora zone through the morphology of Martian aurorae.In the model,equivalent currents are proposed;the topology and magnitude of the magnetic field generated by these equivalent currents are consistent with that of the crustal magnetic field in the Martian aurora zone.The morphology of the Martian aurora zone generated through the model matches well with the observations made by the Mars Express

  4. Jupiter's Mid-Infrared Aurora: Solar Connection and Minor Constituents

    Science.gov (United States)

    Kostiuk, Theodore; Livengood, T.A.; Fast, K.E.; Hewagama, T.; Schmilling, F.; Sonnabend, G.; Delgado, J.

    2009-01-01

    High spectral resolution in the 12 pin region of the polar regions of Jupiter reveal unique information on auroral phenomena and upper stratospheric composition. Polar aurorae in Jupiter's atmosphere radiate; throughout the electromagnetic spectrum from X-ray through mid-infrared (mid-IR, 5 - 20 micron wavelength). Voyager IRIS data and ground-based. spectroscopic measurements of Jupiter's northern mid-IR aurora acquired since 1982, reveal a correlation between auroral brightness and solar activity that has not been observed in Jovian aurora at other wavelengths. Over nearly three solar cycles, Jupiter auroral ethane, emission brightness and solar 10.7-cm radar flux and sunspot number are positively correlated with high confidence. Ethane line emission intensity varies over tenfold between low and high scalar activity periods. Detailed measurements have been made using the GSFC HIPWAC spectrometer at the NASA IRTF since the last solar maximum, following the mid-IR emission through the declining phase toward solar minimum. An even more convincing correlation with solar activity is evident in these data. The spectra measured contain features that cannot be attributed to ethane and are most likely spectra of minor constituents whose molecular bands overlap the v9 band of ethane. Possible candidates are allene, propane, and other higher order hydrocarbons. These features appear to be enhanced in the active polar regions. Laboratory measurements at comparable spectral resolution of spectra of candidate molecules will be used to identify the constituents. Current analyses of these results will be described, including planned measurements on polar ethane line emission scheduled through the rise of the next solar maximum beginning in 2009, with a steep gradient to a maximum in 2012. This work is relevant to the Juno mission and to the development of the NASA/ESA Europa Jupiter System Mission.

  5. First Terrestrial Soft X-ray Aurora Observations by Chandra

    Science.gov (United States)

    Bhardwaj, Anil; Elsner, Ronald F.; Gladstone, G. Randall; Waite, J. Hunter, Jr.; Cravens, Thomas E.; Ostgaard, Nikolai; Chang, Shen-Wu; Metzger, Albert E.; Majeed, Tariq

    2004-01-01

    Northern polar "auroral" regions of Earth was observed by High-Resolution Camera in imaging mode (T32C-I) aboard Chandra X-Ray Observatory (CXO) during mid December 2003 - mid April 2004. Ten CXO observations, each approximately 20 min duration, were made in a non-conventional method (due to CXO technical issues), such that Chandra was aimed at a fixed point in sky and the Earth's polar cusp was allowed to drift through the HRC-I field-of-view. The observations were performed when CXO was near apogee and timed during northern winter mostly near midnight (6 hr), except two observations which occurred around 1200 UT, so that northern polar region is entirely in dark and solar fluoresced x-ray contamination can be avoided. These observations were aimed at searching the Earth's soft x-ray aurora and to do a comparative study with Jupiter's x-ray aurora, where a pulsating x-ray hot-spot near the northern magnetic pole has been observed by Chandra that implies a particle source region near Jupiter's magnetopause, and entry of heavy solar wind ions due to high-latitude reconnection as a viable explanation for the soft x-ray emissions. The first Chandra soft (0.1-2 keV) x-ray observations of Earth's aurora show that it is highly variable (intense arc, multiple arcs, diffuse, at times almost absent). In at least one of the observations an isolated blob of emission is observed where we expect cusp to be: giving indication of solar wind charge-exchange signature in x-rays. We are comparing the Chandra x-ray observations with observations at other wavelengths and particle data from Earth-orbiting satellites and solar wind measurements from near-Earth ACE and SOH0 spacecraft. Preliminary results from these unique CXO-Earth observations will be presented and discussed.

  6. The Aurora B kinase in chromosome biorientation and spindle checkpoint signalling

    Directory of Open Access Journals (Sweden)

    Veronica eKrenn

    2015-10-01

    Full Text Available Aurora B, a member of the Aurora family of serine/threonine protein kinases, is a key player in chromosome segregation. As part of a macromolecular complex known as the chromosome passenger complex, Aurora B concentrates early during mitosis in the proximity of centromeres and kinetochores, the sites of attachment of chromosomes to spindle microtubules. There, it contributes to a number of processes that impart fidelity to cell division, including kinetochore stabilization, kinetochore-microtubule attachment, and the regulation of a surveillance mechanism named the spindle assembly checkpoint. In the regulation of these processes, Aurora B is the fulcrum of a remarkably complex network of interactions that feed back on its localization and activation state. In this review we discuss the multiple roles of Aurora B during mitosis, focusing in particular on its role at centromeres and kinetochores. Many details of the network of interactions at these locations remain poorly understood, and we focus here on several crucial outstanding questions.

  7. Expression of Aurora-B and FOXM1 predict poor survival in patients with nasopharyngeal carcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Huang, Pei-Yu; Luo, Dong-Hua; Mai, Hai-Qiang [State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou (China); Sun Yat-sen University Cancer Center, Department of Nasopharyngeal Carcinoma, Guangzhou (China); Li, Yan; Zeng, Ting-Ting; Li, Meng-Qing [State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou (China); Hou, Xue; Zhang, Li [State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou (China); Sun Yat-sen University Cancer Center, Department of Medical Oncology, Guangzhou (China)

    2015-08-15

    The purpose of this work was to investigate the relationship between Aurora-B, FOXM1, and clinical outcomes in patients with nasopharyngeal carcinoma (NPC) who were treated with a combination of induction chemotherapy and radiotherapy. The expression of Aurora-B and FOXM1 were investigated by immunohistochemistry using a tissue microarray (TMA) containing samples from 166 NPC patients who were treated with cisplatin (DDP) + fluorouracil (5-FU) induction chemotherapy and radiotherapy between 1999 and 2005. The relationship of Aurora-B, FOXM1, and survival of these NPC patients was analyzed. Informative TMA results were obtained in 91 tumor cases for Aurora-B and 93 tumor cases for FOXM1. The 8-year failure-free survival rate (FFS) for the Aurora-B-negative and Aurora-B-positive group was 65.6 and 37.3 %, respectively (p = 0.024), and the 8-year distant FFS (D-FFS) rate was 65.6 and 41.5 %, respectively (p = 0.047). The 8-year overall survival (OS) in the FOXM1-negative group was moderately higher than in the FOXM1-positive group (58.4 vs 39.1 %, p = 0.081). Cox regression analysis revealed that for FFS, Aurora-B expression was a significant prognostic factor (p = 0.025), while for D-FFS, Aurora-B expression was a marginally significant prognostic factor (p = 0.056). When FOXM1 expression was analyzed, the Cox regression analyses showed that FOXM1 expression was a marginally significant prognostic factor (p = 0.056) for OS. Correlation analysis showed that Aurora-B and FOXM1 expression had no significant correlation. Aurora-B and FOXM1 were both adverse prognostic markers for NPC patients treated with chemoradiotherapy. However, the two markers had no significant correlation. (orig.) [German] Ziel war die Untersuchung der Beziehung zwischen Aurora-B, FOXM1 und den klinischen Ergebnissen bei Patienten mit nasopharyngealem Karzinom (NPC), die mit einer Kombinationstherapie aus Induktionschemotherapie und Radiotherapie behandelt wurden. Die Expression von Aurora-B und

  8. Expression of Aurora-B and FOXM1 predict poor survival in patients with nasopharyngeal carcinoma

    International Nuclear Information System (INIS)

    The purpose of this work was to investigate the relationship between Aurora-B, FOXM1, and clinical outcomes in patients with nasopharyngeal carcinoma (NPC) who were treated with a combination of induction chemotherapy and radiotherapy. The expression of Aurora-B and FOXM1 were investigated by immunohistochemistry using a tissue microarray (TMA) containing samples from 166 NPC patients who were treated with cisplatin (DDP) + fluorouracil (5-FU) induction chemotherapy and radiotherapy between 1999 and 2005. The relationship of Aurora-B, FOXM1, and survival of these NPC patients was analyzed. Informative TMA results were obtained in 91 tumor cases for Aurora-B and 93 tumor cases for FOXM1. The 8-year failure-free survival rate (FFS) for the Aurora-B-negative and Aurora-B-positive group was 65.6 and 37.3 %, respectively (p = 0.024), and the 8-year distant FFS (D-FFS) rate was 65.6 and 41.5 %, respectively (p = 0.047). The 8-year overall survival (OS) in the FOXM1-negative group was moderately higher than in the FOXM1-positive group (58.4 vs 39.1 %, p = 0.081). Cox regression analysis revealed that for FFS, Aurora-B expression was a significant prognostic factor (p = 0.025), while for D-FFS, Aurora-B expression was a marginally significant prognostic factor (p = 0.056). When FOXM1 expression was analyzed, the Cox regression analyses showed that FOXM1 expression was a marginally significant prognostic factor (p = 0.056) for OS. Correlation analysis showed that Aurora-B and FOXM1 expression had no significant correlation. Aurora-B and FOXM1 were both adverse prognostic markers for NPC patients treated with chemoradiotherapy. However, the two markers had no significant correlation. (orig.)

  9. Basal aurora kinase B activity is sufficient for histone H3 phosphorylation in prophase

    Directory of Open Access Journals (Sweden)

    Ly-Thuy-Tram Le

    2013-02-01

    Histone H3 phosphorylation is the hallmark of mitosis deposited by aurora kinase B. Benzo[e]pyridoindoles are a family of potent, broad, ATP-competitive aurora kinase inhibitors. However, benzo[e]pyridoindole C4 only inhibits histone H3 phosphorylation in prophase but not in metaphase. Under the C4 treatment, the cells enter into mitosis with dephosphorylated histone H3, assemble chromosomes normally and progress to metaphase, and then to anaphase. C4 also induces lagging chromosome in anaphase but we demonstrated that these chromosome compaction defects are not related to the absence of H3 phosphorylation in prophase. As a result of C4 action, mitosis lasts longer and the cell cycle is slowed down. We reproduced the mitotic defects with reduced concentrations of potent pan aurora kinase as well as with a specific aurora B ATP-competitive inhibitor; we therefore propose that histone H3 phosphorylation and anaphase chromosome compaction involve the basal activity of aurora kinase B. Our data suggest that aurora kinase B is progressively activated at mitosis entry and at anaphase onset. The full activation of aurora kinase B by its partners, in prometaphase, induces a shift in the catalytic domain of aurora B that modifies its affinity for ATP. These waves of activation/deactivation of aurora B correspond to different conformations of the chromosomal complex revealed by FRAP. The presence of lagging chromosomes may have deleterious consequences on the daughter cells and, unfortunately, the situation may be encountered in patients receiving treatment with aurora kinase inhibitors.

  10. Inhibition of Survivin and Aurora B Kinase Sensitizes Mesothelioma Cells by Enhancing Mitotic Arrests

    International Nuclear Information System (INIS)

    Purpose: Survivin, a member of the inhibitor of apoptosis gene family, has also been shown to regulate mitosis. It binds Aurora B kinase and the inner centromere protein to form the chromosome passenger complex. Both Aurora B and survivin are overexpressed in many tumors. In this study, we examined whether irradiation affected survivin and Aurora B expression in mesothelioma cells, and how inhibition of these molecules affected radiosensitivity. Methods and Materials: ZM447439 and survivin antisense oligonucleotides were used to inhibit survivin and Aurora B kinase respectively. Western blot was performed to determine the expression of survivin, Aurora B, phosphorylated-histone H3 (Ser 10), and caspase cleavage. Multinucleated cells were counted using flow cytometry, and cell survival after treatment was determined using clonogenic assay. Results: At 3-Gy irradiation an increase was observed in levels of survivin and Aurora B as well as the kinase activity of Aurora B, with an increase in G2/M phase. The radiation-induced upregulation of these molecules was effectively attenuated by antisense oligonucleotides against survivin and a small-molecule inhibitor of Aurora B, ZM447439. Dual inhibition of survivin and Aurora B synergistically radiosensitized mesothelioma cells with a dose enhancement ratio of 2.55. This treatment resulted in increased formation of multinucleated cells after irradiation but did not increase levels of cleaved caspase 3. Conclusion: Inhibition of survivin and Aurora B induces mitotic cell arrest in mesothelioma cells after irradiation. These two proteins may be potential therapeutic targets for the enhancement of radiotherapy in malignant pleural mesothelioma

  11. Arsenic-induced Aurora-A activation contributes to chromosome instability and tumorigenesis

    Science.gov (United States)

    Wu, Chin-Han; Tseng, Ya-Shih; Yang, Chao-Chun; Kao, Yu-Ting; Sheu, Hamm-Ming; Liu, Hsiao-Sheng

    2013-11-01

    Arsenic may cause serious environmental pollution and is a serious industrial problem. Depending on the dosage, arsenic may trigger the cells undergoing either proliferation or apoptosis-related cell death. Because of lack of the proper animal model to study arsenic induced tumorigenesis, the accurate risk level of arsenic exposure has not been determined. Arsenic shows genotoxic effect on human beings who uptake water contaminated by arsenic. Chromosome aberration is frequently detected in arsenic exposure-related diseases and is associated with increased oxidative stress and decreased DNA repairing activity, but the underlying mechanism remains elusive. Aurora-A is a mitotic kinase, over-expression of Aurora-A leads to centrosome amplification, chromosomal instability and cell transformation. We revealed that Aurora-A is over-expressed in the skin and bladder cancer patients from blackfoot-disease endemic areas. Our cell line studies reveal that arsenic exposure between 0.5 μM and 1 μM for 2-7 days are able to induce Aurora-A expression and activation based on promoter activity, RNA and protein analysis. Aurora-A overexpression further increases the frequency of unsymmetrical chromosome segregation through centrosome amplification followed by cell population accumulated at S phase in immortalized keratinocyte (HaCaT) and uroepithelial cells (E7). Furthermore, Aurora-A over-expression was sustained for 1-4 weeks by chronic treatment of immortalized bladder and skin cells with NaAsO2. Aurora-A promoter methylation and gene amplification was not detected in the long-term arsenic treated E7 cells. Furthermore, the expression level of E2F1 transcription factor (E2F1) is increased in the presence of arsenic, and arsenic-related Aurora-A over-expression is transcriptionally regulated by E2F1. We further demonstrated that overexpression of Aurora-A and mutant Ha-ras or Aurora-A and mutant p53 may act additively to trigger arsenic-related bladder and skin cancer

  12. Interpretation of electron spectra in morningside pulsating aurorae

    International Nuclear Information System (INIS)

    Energy spectra of precipitating electrons in morningside aurorae were obtained with instruments on the NOAA 6 satellite during several passes through the southern auroral zone in 1982. It is substantiated with the aid of coordinated data from particle detectors and a photometer in the Simulated Emission of Energetic Particles experiment payload on satellite S81-1 that the precipitation obserbed by NOAA 6 was probably in a region of pulsating aurorae. The particle detectors and forward/downward looking quadrant photometer onboard S81-1 all exhibited regular modulations at a period of about 5--15 s. The particle detectors on NOAA 6 showed fluctuating electron intensities over an energy range from several kiloelectronvolts to many tens of kiloelectronvolts, superimposed on a steady background component extending down to energies less than 1 keV. The NOAA 6 electron observations are in qualitative agreement with a time-dependent precipitation model that includes the production of backscattered and secondary electrons from the atmosphere. In this model the time variations imposed on the precipitation are restricted to the energetic portion of the electron spectrum, while the integrating effects inherent in the production of backscattered and secondary electrons, together with phase mixing introduced as those electrons transit between conjugate hemispheres, insure the existence of a nearly time independent population of low-energy electrons. A steady background precipitation is thereby created as a natural consequence of a time-variable primary precipitation. copyright American Geophysical Union 1987

  13. X-ray scanning of overhead aurorae from rockets

    International Nuclear Information System (INIS)

    Two Nike Tomahawk rocket payloads were launched into energetic auroral events to investigate their structure and effects on the atmosphere. The instrument complement included X-ray scintillation detectors with energy discrimination in four ranges to measure the deposition of bremsstrahlung produced X-rays within the stratosphere and mesosphere. For this purpose, each instrument was designed for wide angle viewing; however, properties of the rocket motion have permitted coarse observation of distinct spatial X-ray structure. The detectors were mounted at a 450 angle with respect to the payload axis to permit scanning of the upper hemisphere, with rocket spin rates near 5 c/s during the upleg portion of each flight. Here, atmospheric shielding reduced energetic particle contamination effects to insignificant values below 65 to 75 km. Iterative computer techniques were used to reconstruct X-ray source maps at 100 km, taking atmospheric absorption effects into account. Payload 18.178 was launched on 21 September (0302 LMT) into an aurora observed to have two distinct azimuthal regions of optical brightness. Payload 18.179 (23 September, 0147 LMT) was launched into an aurora of more diffuse character. The presence of a two component spectrum is indicated for each event with the hard component originating in the more diffuse, optically faint regions. (author)

  14. A specific pharmacophore model of Aurora B kinase inhibitors and virtual screening studies based on it.

    Science.gov (United States)

    Wang, Hui-Yuan; Li, Lin-Li; Cao, Zhi-Xing; Luo, Shi-Dong; Wei, Yu-Quan; Yang, Sheng-Yong

    2009-01-01

    In this study, 3D-pharmacophore models of Aurora B kinase inhibitors have been developed by using HipHop and HypoGen modules in Catalyst software package. The best pharmacophore model, Hypo1, which has the highest correlation coefficient (0.9911), consists of one hydrogen-bond acceptor, one hydrogen-bond donor, one hydrophobic aliphatic moiety and one ring aromatic feature. Hypo1 was validated by test set and cross-validation methods. And the specificity of Hypo1 to Aurora B inhibitors was examined with the use of selective inhibitors against Aurora B and its paralogue Aurora A. The results clearly indicate that Hypo1 can differentiate selective inhibitors of Aurora B from those of Aurora A, and the ring aromatic feature likely plays some important roles for the specificity of Hypo1. Then Hypo1 was used as a 3D query to screen several databases including Specs, NCI, Maybridge and Chinese Nature Product Database (CNPD) for identifying new inhibitors of Aurora B. The hit compounds were subsequently subjected to filtering by Lipinski's rule of five and docking studies to refine the retrieved hits, and some compounds selected from the top ranked hits have been suggested for further experimental assay studies. PMID:19152640

  15. Survivin inhibits anti-growth effect of p53 activated by aurora B

    International Nuclear Information System (INIS)

    Genomic instability and apoptosis evasion are hallmarks of cancer, but the molecular mechanisms governing these processes remain elusive. Here, we found that survivin, a member of the apoptosis-inhibiting gene family, and aurora B kinase, a chromosomal passenger protein, were co-overexpressed in the various glioblastoma cell lines and tumors. Notably, exogenous introduction of the aurora B in human BJ cells was shown to decrease cell growth and increase the senescence-associated β-galactosidase activity by activation of p53 tumor suppressor. However, aurora B overexpression failed to inhibit cell proliferation in BJ and U87MG cells transduced with dominant-negative p53 as well as in p53-/- mouse astrocytes. Aurora B was shown to increase centrosome amplification in the p53-/- astrocytes. Survivin was shown to induce anchorage-independent growth and inhibit anti-proliferation and drug-sensitive apoptosis caused by aurora B. Overexpression of both survivin and aurora B further accelerated the proliferation of BJ cells. Taken together, the present study indicates that survivin should accelerate tumorigenesis by inhibiting the anti-proliferative effect of p53 tumor suppressor that is activated by aurora B in normal and glioblastoma cells containing intact p53

  16. Aurora candidates from the chronicle of Qíng dynasty in several degrees of relevance

    Science.gov (United States)

    Kawamura, Akito D.; Hayakawa, Hisashi; Tamazawa, Harufumi; Miyahara, Hiroko; Isobe, Hiroaki

    2016-08-01

    We present the result of a survey of sunspots and auroras in Qíngshǐgǎo (清史稿), a draft chronicle of Qíng dynasty, for the period of 1559-1912 CE. This is a sequel to a series of works surveying historical sunspot and aurora records, and providing online data to the scientific community regarding the attained results. In total of this Qíngshǐgǎo survey, we found 111 records of night-sky luminous events with such keywords as vapor (氣, qì), cloud (雲, yún), and light (光, guāng), which may indicate auroras as well as some other phenomena. Similarly, a keyword survey for sunspots was conducted, but no sunspot record was found. In comparison with the aurora records in the western world, we found that 14 of the 111 records have a corresponding record of simultaneous observation in the western world, and hence are very likely to be aurora. In order to investigate the likeliness of the remainder of the record being aurora, we calculated the lunar age and the phase of a solar cycle for each record. After these calculations, a notable fraction of these records clustered near the full moon were to be found statistically doubtful in considerations with atmospheric optics; meanwhile, a few records of observations near the new moon could be more likely interpreted as being auroras, including three records during the Maunder minimum.

  17. MLN-8237: A dual inhibitor of aurora A and B in soft tissue sarcomas

    Science.gov (United States)

    Nair, Jayasree S.; Schwartz, Gary K.

    2016-01-01

    Aurora kinases have become an attractive target in cancer therapy due to their deregulated expression in human tumors. Liposarcoma, a type of soft tissue sarcoma in adults, account for approximately 20% of all adult soft tissue sarcomas. There are no effective chemotherapies for majority of these tumors. Efforts made to define the molecular basis of liposarcomas lead to the finding that besides the amplifications of CDK4 and MDM2, Aurora Kinase A, also was shown to be overexpressed. Based on these as well as mathematic modeling, we have carried out a successful preclinical study using CDK4 and IGF1R inhibitors in liposarcoma. MLN8237 has been shown to be a potent and selective inhibitor of Aurora A. MLN-8237, as per our results, induces a differential inhibition of Aurora A and B in a dose dependent manner. At a low nanomolar dose, cellular effects such as induction of phospho-Histone H3 (Ser10) mimicked as that of the inhibition of Aurora kinase A followed by apoptosis. However, micromolar dose of MLN-8237 induced polyploidy, a hallmark effect of Aurora B inhibition. The dose dependent selectivity of inhibition was further confirmed by using siRNA specific inhibition of Aurora A and B. This was further tested by time lapse microscopy of GFP-H2B labelled cells treated with MLN-8237. LS141 xenograft model at a dose of 30 mg/kg also showed efficient growth suppression by selective inhibition of Aurora Kinase A. Based on our data, a dose that can target only Aurora A will be more beneficial in tumor suppression. PMID:26887042

  18. Dual Aurora A and JAK2 kinase blockade effectively suppresses malignant transformation

    OpenAIRE

    Hua YANG; Lawrence, Harshani R.; Kazi, Aslamuzzaman; Gevariya, Harsukh; Patel, Ronil; Luo, Yunting; Rix, Uwe; Schonbrunn, Ernst; Lawrence, Nicholas J.; Sebti, Said M.

    2014-01-01

    Aurora A and JAK2 kinases are involved in cell division and tumor cell survival, respectively. Here we demonstrate that ectopic expression of Aurora A and JAK2 together is more effective than each alone at inducing non-transformed cells to grow in an anchorage-independent manner and to invade. Furthermore, siRNA silencing or pharmacological inhibition of Aurora A and JAK2 with Alisertib and Ruxolitinib, respectively, is more effective than blocking each kinase alone at suppressing anchorage-d...

  19. Exploring the Secrets of the Aurora Second Edition

    CERN Document Server

    Akasofu, Syun-Ichi

    2007-01-01

    This new edition of Exploring the Secrets of the Aurora is based on the author's own experiences as a scientist. It describes the history of progress made in auroral science and magnetospheric physics by providing examples of ideas, controversies, struggles, acceptance, and success. Although no general methodologies are mentioned, the hope is that the reader will learn about the history of progress in auroral science and examples of dealing with the many controversies. This book aims to help young scientific researchers learn how to persevere during periods of controversy and struggles for acceptance. In this second edition, by utilizing multiple examples, Akasofu is successful in demonstrating the importance and usefulness of Synthesis. "Probably the book's most valuable contribution to the history of space physics is precisely the narration of the discovery of substorms.---The book has special features.---Akasofu's coverage of the history of pre-space age solar-terrestrial relations is the most comprehensiv...

  20. Beam propagation considerations in the Aurora laser system

    International Nuclear Information System (INIS)

    Aurora is a high-power KrF laser system now being constructed for inertial confinement fusion (ICF) studies. It will use optical angular multiplexing and serial amplification by electron-beam-driven KrF amplifiers to deliver a stacked, multikilojoule 5-ns-duration laser pulse to ICF targets. The requirements of angular multiplexing KrF lasers at the multikilojoule level dictate path lengths on the order of 1 km. The inherent complicated path crossings produced by angular multiplexing and pulse stacking do not allow isolation of individual beam lines, so the optical quality of the long beam paths must be controlled. Propagation of the 248-nm light beams over long paths in air is affected by scattering, absorption thermal gradients and turbulence, beam alignment, and control and optical component figure errors

  1. Jupiter's north and south polar aurorae with IUE data

    International Nuclear Information System (INIS)

    Observations of Jupiter's auroral H2 emissions with the IUE spacecraft, from 1978 through 1990, show the aurorae at the two poles are similar in several respects: (a) emission intensity is modulated with magnetic longitude, north peak emission at λIII (1965) ∼ 200 degree, south peak at λIII (1965) ∼ 20 degree; (b) emission intensity and degree of modulation are comparable for both poles; (c) attenuation by hydrocarbons varies in phase with the intensity, peak attenuation coinciding approximately with peak emission. Increases in the hydrocarbon column are an indicator of either enhanced penetration depth and thus energy of the auroral primaries, or of increases in the high-altitude hydrocarbon content caused by modification of the local atmosphere

  2. Centromeric Transcription Regulates Aurora-B Localization and Activation

    Directory of Open Access Journals (Sweden)

    Michael D. Blower

    2016-05-01

    Full Text Available Centromeric transcription is widely conserved; however, it is not clear what role centromere transcription plays during mitosis. Here, I find that centromeres are transcribed in Xenopus egg extracts into a long noncoding RNA (lncRNA; cen-RNA that localizes to mitotic centromeres, chromatin, and spindles. cen-RNAs bind to the chromosomal passenger complex (CPC in vitro and in vivo. Blocking transcription or antisense inhibition of cen-RNA leads to a reduction of CPC localization to the inner centromere and misregulation of CPC component Aurora-B activation independently of known centromere recruitment pathways. Additionally, transcription is required for normal bipolar attachment of kinetochores to the mitotic spindle, consistent with a role for cen-RNA in CPC regulation. This work demonstrates that cen-RNAs promote normal kinetochore function through regulation of the localization and activation of the CPC and confirm that lncRNAs are components of the centromere.

  3. The Aurora kinase inhibitors in cancer research and therapy.

    Science.gov (United States)

    Cicenas, Jonas

    2016-09-01

    Compounds that affect enzymatic function of kinases are valuable for the understanding of the complex biochemical processes in cells. Aurora kinases (AURKs) play a key role in the control of the mitosis. These kinases are frequently deregulated in different human cancers: overexpression, amplifications, translocations and deletions were reported in many cancer cell lines as well as patient tissues. These findings steered a rigorous hunt for small-molecule AURK inhibitors not only for research purposes as well as for therapeutic uses. In this review, we describe a number of AURK inhibitors and their use in cancer research and/or therapy. We hope to assist researchers and clinicians in deciding which inhibitor is most appropriate for their specific purpose. The review will also provide a broad overview of the clinical studies performed with some of these inhibitors (if such studies have been performed). PMID:26932147

  4. Field-aligned electron flux oscillations that produce flickering aurora

    International Nuclear Information System (INIS)

    Measurements of energetic electrons that produce flickering aurora were made by a pair of sounding rockets launched during a slowly evolving auroral breakup. Both payloads passed through a broad inverted-V structure. A component of the electron distribution function was closely aligned with the magnetic field over a broad energy range that extended form low energies up to the inverted-V differential energy flux peak. High time resolution measurements of the field-aligned component showed the presence of order to magnitude coherent flux oscillations. Source altitudes between 4,000 and 8,000 km were derived from velocity dispersion of the flux oscillations. A ground-based TV camera recorded visual flickering in the vicinity of the payloads' auroral footprints during periods when flux oscillations were present. Measurements are compared with previous observations of electron flux oscillations, and possible sources for the field-aligned component are discussed

  5. The charge spectrum of positive ions in a hydrogen aurora

    Science.gov (United States)

    Lynch, J.; Pulliam, D.; Leach, R.; Scherb, F.

    1976-01-01

    An auroral ion charge spectrometer was flown into a hydrogen aurora on a Javelin sounding rocket launched from Churchill, Manitoba. The instrument contained an electrostatic analyzer which selected particles with incident energy per unit charge up to 20 keV/charge and an 80-kV power supply which accelerated these ions onto an array of solid state detectors. Ions tentatively identified as H(+), He(+2), and O(+) were detected from 225 to 820 km in altitude. The experiment did not discriminate between H(+) and He(+), or between O(+), N(+), and C(+). Upper limits of highly charged heavy ion abundances have been set at 20% of the He(+2) and 0.15% of the H(+). It is concluded that both terrestrial and solar wind sources play significant roles in auroral ion precipitation.

  6. New contributions for the assessment of intelligence : the Aurora Battery

    OpenAIRE

    Salgado, Ana Manuela Faria

    2014-01-01

    Dissertação de mestrado integrado em Psicologia A avaliação da inteligência representa um dos domínios mais divulgados e controversos da Psicologia. Em resposta às críticas aos testes clássicos de inteligência emergiu a Bateria Aurora, destinada a crianças na faixa etária dos 9-12 anos e enquadrada na Teoria Triárquica de Robert Sternberg. Esta bateria visa o diagnóstico da sobredotação através da avaliação da inteligência prática, analítica e criativa, apresentando itens figur...

  7. Forecasting auroras from regional and global magnetic field measurements

    Science.gov (United States)

    Kauristie, Kirsti; Myllys, Minna; Partamies, Noora; Viljanen, Ari; Peitso, Pyry; Juusola, Liisa; Ahmadzai, Shabana; Singh, Vikramjit; Keil, Ralf; Martinez, Unai; Luginin, Alexej; Glover, Alexi; Navarro, Vicente; Raita, Tero

    2016-06-01

    We use the connection between auroral sightings and rapid geomagnetic field variations in a concept for a Regional Auroral Forecast (RAF) service. The service is based on statistical relationships between near-real-time alerts issued by the NOAA Space Weather Prediction Center and magnetic time derivative (dB/dt) values measured by five MIRACLE magnetometer stations located in Finland at auroral and sub-auroral latitudes. Our database contains NOAA alerts and dB/dt observations from the years 2002-2012. These data are used to create a set of conditional probabilities, which tell the service user when the probability of seeing auroras exceeds the average conditions in Fennoscandia during the coming 0-12 h. Favourable conditions for auroral displays are associated with ground magnetic field time derivative values (dB/dt) exceeding certain latitude-dependent threshold values. Our statistical analyses reveal that the probabilities of recording dB/dt exceeding the thresholds stay below 50 % after NOAA alerts on X-ray bursts or on energetic particle flux enhancements. Therefore, those alerts are not very useful for auroral forecasts if we want to keep the number of false alarms low. However, NOAA alerts on global geomagnetic storms (characterized with Kp values > 4) enable probability estimates of > 50 % with lead times of 3-12 h. RAF forecasts thus rely heavily on the well-known fact that bright auroras appear during geomagnetic storms. The additional new piece of information which RAF brings to the previous picture is the knowledge on typical storm durations at different latitudes. For example, the service users south of the Arctic Circle will learn that after a NOAA ALTK06 issuance in night, auroral spotting should be done within 12 h after the alert, while at higher latitudes conditions can remain favourable during the next night.

  8. Realidad, mito y deseo. La mirada grecolatina de Aurora Luque

    Directory of Open Access Journals (Sweden)

    Virtanen, Ricardo

    2011-08-01

    Full Text Available Aurora Luque’s poetry is one of the most representative of contemporary poetry, located within a Greek culturalism, where myth and reality blend into everyday life. Luque’s poetry is characterized by irony, nonchalance, frivolity and dedramatization. The article presents a series of poems where one can find a demystification of the classical element. A poetry stressed by some topoi such as carpe diem or Catullus’ odio et amo, which have been always represented from a light-hearted glance ruled by the spirit of Eros. The article also emphasizes the play on intertextuality –following Catullus– as well as the epicurean inclination/spirit/passion of the autor.

    La poesía de Aurora Luque representa una de las poéticas más representativas de nuestra contemporaneidad, ubicada dentro de un culturalismo grecista, donde mito y realidad se conjugan dentro de la cotidianidad. La poesía de Luque se caracteriza por su ironía, desenfado, frivolidad y desdramatización. El artículo presenta una serie de poemas donde se produce una desmitificación del elemento clásico. Una poesía marcada por algunos topoi como el carpe diem o el odio et amo catuliano, siempre representados desde una mirada desenfada y dominada por el espíritu del Eros. El artículo destaca además el juego de intertextualidad –en seguimiento de Catulo– así como la vocación epicúrea de la autora.

  9. Aurora B inhibitor barasertib prevents meiotic maturation and subsequent embryo development in pig oocytes.

    Science.gov (United States)

    Ju, Shiqiang; Peng, Xu; Yang, Xiaoliu; Sozar, Sparksi; Muneri, Caroline W; Xu, Yaping; Chen, Changchao; Cui, Panpan; Xu, Weichao; Rui, Rong

    2016-07-15

    Barasertib, a highly selective Aurora B inhibitor, has been widely used in a variety of cells to investigate the role of Aurora B kinase, which has been implicated in various functions in the mitotic process. However, effects of barasertib on the meiotic maturation process are not fully understood, particularly in porcine oocyte meiotic maturation. In the present study, the effects of barasertib on the meiotic maturation and developmental competence of pig oocytes were investigated, and the possible roles of Aurora B were also evaluated in porcine oocytes undergoing meiosis. Initially, we examined the expression and subcellular localization of Aurora B using Western blot analysis and immunofluorescent staining. Aurora B was found to express and exhibit specific dynamic intracellular localization during porcine oocyte meiotic maturation. Aurora B was observed around the chromosomes after germinal vesicle breakdown. Then it was transferred to the spindle region after metaphase I stage, and was particularly concentrated at the central spindles at telophase I stage. barasertib treatment resulted in the failure of polar body extrusion in pig oocytes, with a larger percentage of barasertib-treated oocytes remaining at the pro-metaphase I stage. Additional results reported that barasertib treatment had no effect on chromosome condensation but resulted in a significantly higher percentage of the treated oocytes with aberrant spindles and misaligned chromosomes during the first meiotic division. In addition, inhibition of Aurora B with lower concentrations of barasertib during pig oocyte meiotic maturation decreased the subsequent embryo developmental competence. Thus, these results illustrate that barasertib has significant effects on porcine oocyte meiotic maturation and subsequent development through Aurora B inhibition, and this regulation is related to its effects on spindle formation and chromosome alignment during the first meiotic division in porcine oocytes. PMID

  10. From the Hubble Space Telescope to Juno, unraveling the secrets of Jupiter's UV aurorae

    OpenAIRE

    Bonfond, Bertrand

    2015-01-01

    The successive generations of instruments on board the Hubble Space Telescope (HST) have revealed an increasing amount of details concerning the aurorae of Jupiter. Among the most striking results is the finding that these aurorae are actually made of a multitude of components arising from a variety of processes, ranging from the local interaction of the Jovian moons with the magnetospheric plasma to solar-wind induced compression of the whole magnetosphere. In this presentation, I will revie...

  11. The aurora sign in a patient with type B Niemann-Pick disease

    International Nuclear Information System (INIS)

    The aurora sign, a sonographic sign found on the sagittal and transverse view, refers to multiple bands of ring-down artifacts posterior to the right hemidiaphragm. Parenchymal lung disease should be suspected when this is present. We report a case of type B Niemann-Pick disease with pulmonary involvement and the aurora sign on abdominal sonography. High-resolution CT of the chest showed corresponding thickened interlobular septa. (orig.)

  12. The aurora sign in a patient with type B Niemann-Pick disease

    Energy Technology Data Exchange (ETDEWEB)

    Costa e. Silva, Eduardo J. da [Instituto Materno Infantil Professor Fernando Figueira, Departamento de Radiologia, Recife, Pernambuco (Brazil); IMIP, Departamento de Radiologia-Rua dos Coelhos, Recife, PE (Brazil); Cavalcanti de Albuquerque, Silvio; Queiroz Praxedes, Eduardo L. de; Amaral, Fernando J. do [Instituto Materno Infantil Professor Fernando Figueira, Departamento de Radiologia, Recife, Pernambuco (Brazil)

    2007-01-15

    The aurora sign, a sonographic sign found on the sagittal and transverse view, refers to multiple bands of ring-down artifacts posterior to the right hemidiaphragm. Parenchymal lung disease should be suspected when this is present. We report a case of type B Niemann-Pick disease with pulmonary involvement and the aurora sign on abdominal sonography. High-resolution CT of the chest showed corresponding thickened interlobular septa. (orig.)

  13. Phosphorylation of CPAP by Aurora-A Maintains Spindle Pole Integrity during Mitosis

    OpenAIRE

    En-Ju Chou; Liang-Yi Hung; Chieh-Ju C. Tang; Wen-Bin Hsu; Hsin-Yi Wu; Pao-Chi Liao; Tang K. Tang

    2016-01-01

    CPAP is required for centriole elongation during S/G2 phase, but the role of CPAP in mitosis is incompletely understood. Here, we show that CPAP maintains spindle pole integrity through its phosphorylation by Aurora-A during mitosis. Depletion of CPAP induced a prolonged delay in mitosis, pericentriolar material (PCM) dispersion, and multiple mitotic abnormalities. Further studies demonstrated that CPAP directly interacts with and is phosphorylated by Aurora-A at serine 467 during mitosis. In...

  14. A Market Analysis for PVD Coating System of Aurora North America

    OpenAIRE

    Chen, Wen-Hao Arthur

    2012-01-01

    Aurora North America, a venture founded by Dr. Da-Yung Wang, endeavours to offer its coating products while providing low-cost, quality solutions to North American manufacturers who apply thin-films to their goods. The objective of this proposed research is to provide a comprehensive analysis of the market opportunities for Aurora. This paper seeks to identify markets that have yet to fully adopt Physical Vapor Deposition (PVD) technology, as well as their potential customers. Market trend of...

  15. Mechanism of action and therapeutic efficacy of Aurora kinase B inhibition in MYC overexpressing medulloblastoma

    OpenAIRE

    Diaz, Roberto Jose; Golbourn, Brian; Faria, Claudia; Picard, Daniel; Shih, David; Raynaud, Denis; Leadly, Michael; MacKenzie, Danielle; Bryant, Melissa; Bebenek, Matthew; Smith, Christian A.; Taylor, Michael D.; Huang, Annie; Rutka, James T.

    2014-01-01

    Medulloblastoma comprises four molecular subgroups of which Group 3 medulloblastoma is characterized by MYC amplification and MYC overexpression. Lymphoma cells expressing high levels of MYC are susceptible to apoptosis following treatment with inhibitors of mitosis. One of the key regulatory kinases involved in multiple stages of mitosis is Aurora kinase B. We hypothesized that medulloblastoma cells that overexpress MYC would be uniquely sensitized to the apoptotic effects of Aurora B inhibi...

  16. Atmospheric response in aurora experiment: Observations of E and F region neutral winds in a region of postmidnight diffuse aurora

    Science.gov (United States)

    Larsen, M. F.; Marshall, T. R.; Mikkelsen, I. S.; Emery, B. A.; Christensen, A.; Kayser, D.; Hecht, J.; Lyons, L.; Walterscheid, R.

    1995-01-01

    The goal of the Atmospheric Response in Aurora (ARIA) experiment carried out at Poker Flat, Alaska, on March 3, 1992, was to determine the response of the neutral atmosphere to the long-lived, large-scale forcing that is characteristic of the diffuse aurora in the post midnight sector. A combination of chemical release rocket wind measurements, instrumented rocket composition measurements, and ground-based optical measurements were used to characterize the response of the neutral atmosphere. The rocket measurements were made at the end of a 90-min period of strong Joule heating. We focus on the neutral wind measurements made with the rocket. The forcing was determined by running the assimilated mapping of ionospheric electrodynamics (AMIE) analysis procedure developed at the National Center for Atmospheric Research. The winds expected at the latitude and longitude of the experiment were calculated using the spectral thermospheric general circulation model developed at the Danish Meteorological Institute. Comparisons of the observations and the model suggest that the neutral winds responded strongly in two height ranges. An eastward wind perturbation of approximately 100 m/s developed between 140 and 200 km altitude with a peak near 160 km. A southwestward wind with peak magnitude of approximately 150 m/s developed near 115 km altitude. The large amplitude winds at the lower altitude are particularly surprising. They appear to be associated with the upward propagating semidiurnal tide. However, the amplitude is much larger than predicted by any of the tidal models, and the shear found just below the peak in the winds was nominally unstable with a Richardson number of approximately 0.08.

  17. A SUMOylation Motif in Aurora-A: Implications in Spindle Dynamics and Oncogenesis

    Directory of Open Access Journals (Sweden)

    MarcosMalumbres

    2011-12-01

    Full Text Available Aurora-A is a serine/threonine kinase that plays critical roles in centrosome maturation, spindle dynamics and chromosome orientation and is frequently found overexpressed in human cancers. In this work, we show that Aurora-A interacts with the SUMO conjugating enzyme UBC9 and co-localizes with SUMO-1 in mitotic cells. Aurora-A can be SUMOylated in vitro and mutation in the highly conserved SUMOylation residue lysine 249 results in the induction of mitotic defects characterized by defective and multipolar spindles. The Aurora-AK249R mutant has normal kinase activity but it displays altered dynamics at the mitotic spindle. In addition, ectopic expression of the Aurora-AK249R mutant results in a significant increase in the susceptibility to malignant transformation induced by the Ras oncogene and an increased protection against apoptosis in tumor cells treated with mitotic poisons. These data suggest that modification by SUMO residues may control Aurora-A function at the spindle and suggest that deficient SUMOylation of this kinase may have relevant implications in tumor development or cancer therapy.

  18. East Asian Observations of Low Latitude Aurora during the Carrington Magnetic Storm

    CERN Document Server

    Hayakawa, Hisashi; Tamazawa, Harufumi; Isobe, Hiroaki; Kataoka, Ryuho; Ebihara, Yusuke; Miyahara, Hiroko; Kawamura, Akito Davis; Shibata, Kazunari

    2016-01-01

    The magnetic storm around 1859 September 2, caused by so-called Carrington flare, was the most intense in the history of modern scientific observations, and hence is considered to be the benchmark event for space weather. The magnetic storm caused worldwide observations of auroras even at very low latitudes such as Hawaii, Panama, or Santiago, and the available magnetic field measurement at Bombay, India, showed two peaks: the main was the Carrington event which occurred in day time in East Asia, and a second storm after the Carrington event which occurred at night in East Asia. In this paper, we present a result from surveys of aurora records in East Asia, which provides new information of the aurora activity of this important event. We found some new East Asian records of low latitude aurora observations caused by the storm which occurred after the Carrington event. The size of the aurora belt of the second peak of the Carrington magnetic storm was even wider than usual low-latitude aurora events.

  19. A statistical study of dayside diffuse aurora observed at Yellow River Station in Ny-Ålesund, Svalbard

    Science.gov (United States)

    Han, D.; Hu, Z.; Hu, H.; Yang, H.; Huang, D. H.; Chen, X.

    2014-12-01

    Chinese Yellow River Station (YRS), at Ny-Alesund, Svalbard is one of the few stations that can make longtime optical auroral observation at the cusp latitude in the dayside during the boreal winter season on the Earth. Since November 2003, an optical observation system consisting of three identical all-sky imagers supplied with the narrow band filters centered at 427.8, 557.5 and 630.0nm, has been installed at YRS, and the continuous observations providing us with an unprecedented opportunity to investigate some new properties of dayside aurora. Optical diffuse auroras are normally observed at the sub-aurora latitude in nightside on the ground. However, by using 7-year continuous observations obtained at YRS, we found that the diffuse auroras are very frequently observed on the dayside at the high latitude, i.e., near the cusp. We classified the dayside diffuse aurora into four primary categories. They are (1) Veiling Diffuse Aurora, which has no obvious morphological structure and clear boundaries, sometimes likes a thick cloud cover the entire sky, (2) Patch Diffuse Aurora, which is an aurora patch normally in ~10-100km in width and usually owns pulsating property; (3) Diffuse Arcs, which looks like an arc but is apparently different from the discrete auroral arcs in morphology, and (4) Pulsating Aurora, occurring with sparkling forms. We statistical studied how the occurrence of the four types of dayside diffuse auroras depends on the local time, magnetic activity, and solar wind conditions. We found that the occurrence of each type of dayside diffuse aurora shows a unimodal distribution with magnetic local time and their peaks are mostly appeared near the magnetic local noon. We also noted that ~92.2% of the dayside diffuse auroras is observed under low magnetic activity, i.e., Kp ≤ 3, and the dayside diffuse auroras prefer to be observed under IMF By0. Although previous studies suggested that the dayside diffuse aurora should be caused by wave scattering of

  20. Characteristics of north jovian aurora from STIS FUV spectral images

    Science.gov (United States)

    Gustin, J.; Grodent, D.; Ray, L. C.; Bonfond, B.; Bunce, E. J.; Nichols, J. D.; Ozak, N.

    2016-04-01

    We analyzed two observations obtained in Jan. 2013, consisting of spatial scans of the jovian north ultraviolet aurora with the HST Space Telescope Imaging Spectrograph (STIS) in the spectroscopic mode. The color ratio (CR) method, which relates the wavelength-dependent absorption of the FUV spectra to the mean energy of the precipitating electrons, allowed us to determine important characteristics of the entire auroral region. The results show that the spatial distribution of the precipitating electron energy is far from uniform. The morning main emission arc is associated with mean energies of around 265 keV, the afternoon main emission (kink region) has energies near 105 keV, while the 'flare' emissions poleward of the main oval are characterized by electrons in the 50-85 keV range. A small scale structure observed in the discontinuity region is related to electrons of 232 keV and the Ganymede footprint shows energies of 157 keV. Interestingly, each specific region shows very similar behavior for the two separate observations. The Io footprint shows a weak but undeniable hydrocarbon absorption, which is not consistent with altitudes of the Io emission profiles (∼900 km relative to the 1 bar level) determined from HST-ACS observations. An upward shift of the hydrocarbon homopause of at least 100 km is required to reconcile the high altitude of the emission and hydrocarbon absorption. The relationship between the energy fluxes and the electron energies has been compared to curves obtained from Knight's theory of field-aligned currents. Assuming a fixed electron temperature of 2.5 keV, an electron source population density of ∼800 m-3 and ∼2400 m-3 is obtained for the morning main emission and kink regions, respectively. Magnetospheric electron densities are lowered for the morning main emission (∼600 m-3) if the relativistic version of Knight's theory is applied. Lyman and Werner H2 emission profiles, resulting from secondary electrons produced by

  1. AURORA BOREALIS: a polar-dedicated European Research Platform

    Science.gov (United States)

    Wolff-Boenisch, Bonnie; Egerton, Paul; Thiede, Joern; Roberto, Azzolini; Lembke-Jene, Lester

    2010-05-01

    Polar research and in particular the properties of northern and southern high latitude oceans are currently a subject of intense scientific debate and investigations, because they are subject to rapid and dramatic climatic variations. Polar regions react more rapidly and intensively to global change than other regions of the earth. A shrinking of the Arctic sea-ice cover, potentially leading to an opening of sea passages to the north of North America and Eurasia, on the long to a "blue" Arctic Ocean would additionally have a strong impact on transport, commerce and tourism bearing potential risk for humans and complex ecosystems in the future. In spite of their critical role processes and feedbacks, especially in winter but not exclusively, are virtually unknown: The Arctic Ocean for example, it is the only basin of the world's oceans that has essentially not been sampled by the drill ships of the Deep-Sea Drilling Project (DSDP) or the Ocean Drilling Program (ODP) and its long-term environmental history and tectonic structure is therefore poorly known. Exceptions are the ODP Leg 151 and the more recent very successful ACEX-expedition of the Integrated Ocean Drilling Program (IODP) in 2004. To help to address the most pressing questions regarding climate change and related processes, a Pan-European initiative in the field of Earth system science has been put in place: AURORA BOREALIS is the largest environmental research infrastructure on the ESFRI roadmap of the European Community. AURORA BOREALIS is a very powerful research icebreaker, which will enable year-round operations in the Arctic and the Antarctic as well as in the adjacent ocean basins. Equipped with its drilling rig, the vessel is also capable to explore the presently completely unknown Arctic deep-sea floor. Last but not least, the ship is a floating observatory and mobile monitoring platform that permits to measure on a long-term basis comprehensive time series in all research fields relevant to

  2. Antineoplastic effects of an Aurora B kinase inhibitor in breast cancer

    Directory of Open Access Journals (Sweden)

    Velazquez-Torres Guermarie

    2010-02-01

    Full Text Available Abstract Background Aurora B kinase is an important mitotic kinase involved in chromosome segregation and cytokinesis. It is overexpressed in many cancers and thus may be an important molecular target for chemotherapy. AZD1152 is the prodrug for AZD1152-HQPA, which is a selective inhibitor of Aurora B kinase activity. Preclinical antineoplastic activity of AZD1152 against acute myelogenous leukemia, multiple myeloma and colorectal cancer has been reported. However, this compound has not been evaluated in breast cancer, the second leading cause of cancer deaths among women. Results The antineoplastic activity of AZD1152-HQPA in six human breast cancer cell lines, three of which overexpress HER2, is demonstrated. AZD1152-HQPA specifically inhibited Aurora B kinase activity in breast cancer cells, thereby causing mitotic catastrophe, polyploidy and apoptosis, which in turn led to apoptotic death. AZD1152 administration efficiently suppressed the tumor growth in a breast cancer cell xenograft model. In addition, AZD1152 also inhibited pulmonary metastatic nodule formation in a metastatic breast cancer model. Notably, it was also found that the protein level of Aurora B kinase declined after inhibition of Aurora B kinase activity by AZD1152-HQPA in a time- and dose-dependent manner. Investigation of the underlying mechanism suggested that AZD1152-HQPA accelerated protein turnover of Aurora B via enhancing its ubiquitination. Conclusions It was shown that AZD1152 is an effective antineoplastic agent for breast cancer, and our results define a novel mechanism for posttranscriptional regulation of Aurora B after AZD1152 treatment and provide insight into dosing regimen design for this kinase inhibitor in metastatic breast cancer treatment.

  3. Evolution of resistance to Aurora kinase B inhibitors in leukaemia cells.

    Directory of Open Access Journals (Sweden)

    Timothy W Failes

    Full Text Available Aurora kinase inhibitors are new mitosis-targeting drugs currently in clinical trials for the treatment of haematological and solid malignancies. However, knowledge of the molecular factors that influence sensitivity and resistance remains limited. Herein, we developed and characterised an in vitro leukaemia model of resistance to the Aurora B inhibitor ZM447439. Human T-cell acute lymphoblastic leukaemia cells, CCRF-CEM, were selected for resistance in 4 µM ZM447439. CEM/AKB4 cells showed no cross-resistance to tubulin-targeted and DNA-damaging agents, but were hypersensitive to an Aurora kinase A inhibitor. Sequencing revealed a mutation in the Aurora B kinase domain corresponding to a G160E amino acid substitution. Molecular modelling of drug binding in Aurora B containing this mutation suggested that resistance is mediated by the glutamate substitution preventing formation of an active drug-binding motif. Progression of resistance in the more highly selected CEM/AKB8 and CEM/AKB16 cells, derived sequentially from CEM/AKB4 in 8 and 16 µM ZM447439 respectively, was mediated by additional defects. These defects were independent of Aurora B and multi-drug resistance pathways and are associated with reduced apoptosis mostly likely due to reduced inhibition of the catalytic activity of aurora kinase B in the presence of drug. Our findings are important in the context of the use of these new targeted agents in treatment regimes against leukaemia and suggest resistance to therapy may arise through multiple independent mechanisms.

  4. Aurora kinase inhibitors: a new class of drugs targeting the regulatory mitotic system.

    Science.gov (United States)

    Pérez Fidalgo, José Alejandro; Roda, Desamparados; Roselló, Susana; Rodríguez-Braun, Edith; Cervantes, Andrés

    2009-12-01

    The present review gives a perspective on the Aurora kinase family members, their function in normal cells, their role in cancer progression as well as their potential as target for anticancer treatment. Mitosis has been an important target for anticancer therapy development, leading to some specific drugs mainly addressing Tubulines, as a key structure of the mitotic spindle. Vinca alkaloids, taxanes or epotilones are good examples of conventionally developed antimitotic agents. However, novel classes of antineoplastic drugs are being studied, targeting the regulatory system that controls functional aspects of mitosis, such as Aurora or Polo-like kinases or Kinespondin inhibitors. The specific role of the different Aurora kinase proteins as regulator enzymes of the mitotic process in normal cells is discussed. Some of the mechanisms that link Aurora overexpression with cancer are also considered. Thereafter, the clinical and preclinical development of the different Aurora kinase inhibitors is presented. This is nowadays a very active area of therapeutic research and at least, sixteen new compounds are being studied as potential antineoplastic drugs. Most of them are in a very early phase of clinical development. However, we summarized the most recently published findings related with these drugs: main characteristics, way of administration, dose limiting toxicities and recommended doses for further studies. Another important aspect in Aurora kinase inhibition is the study and validation of potential biomarkers to optimize the clinical development. Several studies included pharmacodynamic assessments in normal blood cells, skin or/and tumor biopsies. Several proposals included a higher mitotic index, a decreased number of mitosis with bipolar spindles or normal alignment of chromosomes and inhibition of histone H3 phosphorylation. Future strategies and challenges for trials with Aurora kinase inhibitors are also discussed. PMID:20045785

  5. HST/STIS Ultraviolet Imaging of Polar Aurora on Ganymede

    CERN Document Server

    Feldman, P D; Strobel, D F; Moos, H W; Retherford, K D; Wolven, B C; Feldman, Paul D.; Grath, Melissa A. Mc; Strobel, Darrell F.; Retherford, Kurt D.; Wolven, Brian C.

    2000-01-01

    We report new observations of the spectrum of Ganymede in the spectral range 1160 - 1720 A made with the Space Telescope Imaging Spectrograph (STIS) on HST on 1998 October 30. The observations were undertaken to locate the regions of the atomic oxygen emissions at 1304 and 1356 A, previously observed with the GHRS on HST, that Hall et al. (1998) claimed indicated the presence of polar aurorae on Ganymede. The use of the 2" wide STIS slit, slightly wider than the disk diameter of Ganymede, produced objective spectra with images of the two oxygen emissions clearly separated. The OI emissions appear in both hemispheres, at latitudes above 40 degrees, in accordance with recent Galileo magnetometer data that indicate the presence of an intrinsic magnetic field such that Jovian magnetic field lines are linked to the surface of Ganymede only at high latitudes. Both the brightness and relative north-south intensity of the emissions varied considerably over the four contiguous orbits (5.5 hours) of observation, presum...

  6. Spatial scaling of optical fluctuations during substorm-time aurora

    Directory of Open Access Journals (Sweden)

    B. V. Kozelov

    2007-05-01

    Full Text Available A study of statistical features of auroras during substorm activity is presented, emphasizing characteristics which are commonly applied to turbulent flows. Data from all-sky television (TV observations from the Barentsburg observatory (Svalbard have been used. Features of the probability density function (PDF of auroral fluctuations have been examined at different spatial scales. We find that the observed PDFs generally have a non-Gaussian, heavy-tailed shape. The generalized structure function (GSF for the auroral luminosity fluctuations has been analyzed to determine the scaling properties of the higher (up to 6 order moments, and the evolution of the scaling indices during the actual substorm event has been determined. The scaling features obtained can be interpreted as signatures of turbulent motion of the magnetosphere-ionosphere plasma. Relations to previously obtained results of avalanche analysis of the same event, as well as possible implications for the validity of self-organized criticality models and turbulence models of the substorm activity, are discussed.

  7. Ezekiel and the Northern Lights: Biblical aurora seems plausible

    Science.gov (United States)

    Siscoe, George L.; Silverman, Samuel M.; Siebert, Keith D.

    Auroral specialists have suggested that in the Bible's Old Testament book of Ezekiel, the opening vision of a "storm cloud out of the north" depicts imagery inspired by a low-latitude auroral display [Link, 1967; Eather, 1980; Silverman, 1998]. Naturally, other interpretations have been suggested, including a true epiphany, a sandstorm, a thunderstorm, a tornado, a solar halo, a hallucination, and a UFO. Biblical scholars place the site of the Ezekiel's vision about 100 km south of Babylon near Nippur, latitude ˜32°, longitude ˜45°, and the date is within a year or two of 593 B.C., or about 2600 years ago.An auroral interpretation of the vision is subject to possible refutation due to several geophysical considerations. Can auroras be seen at Ezekiel's latitude? More important, can they reach a coronal stage of development, which is what the vision requires? Was the tilt of the dipole axis favorable? Was the general level of solar activity favorable? And finally, What effect does a larger dipole moment in Ezekiel's time have on the question? All but the last question could have been answered on the basis of geophysical data a decade ago or earlier.

  8. Aurora 7 the Mercury space flight of M. Scott Carpenter

    CERN Document Server

    Burgess, Colin

    2016-01-01

    TO A NATION enthralled by the heroic exploits of the Mercury astronauts, the launch of Lt. Cmdr. Scott Carpenter on NASA’s second orbital space flight was a renewed cause for pride, jubilation and celebration. Within hours, that excitement had given way to stunned disbelief and anxiety as shaken broadcasters began preparing the American public for the very real possibility that an American astronaut and his spacecraft may have been lost at sea. In fact, it had been a very close call. Completely out of fuel and forced to manually guide Aurora 7 through the frightening inferno of re-entry, Carpenter brought the Mercury spacecraft down to a safe splashdown in the ocean. In doing so, he controversially overshot the intended landing zone. Despite his efforts, Carpenter’s performance on the MA-7 mission was later derided by powerful figures within NASA. He would never fly into space again. Taking temporary leave of NASA, Carpenter participated in the U.S. Navy’s pioneering Sealab program. For a record 30 days...

  9. Aurora Candidates from the Chronicle of Q\\={i}ng Dynasty in Several Degrees of Relevance

    CERN Document Server

    Kawamura, Akito D; Tamazawa, Harufumi; Miyahara, Hiroko; Isobe, Hiroaki

    2016-01-01

    We present the result of the survey of sunspots and auroras in ${\\it Q\\bar{\\imath}ngsh\\check{\\imath}ga\\check{o}}$, the draft chronicle of ${\\it Q\\bar{\\imath}ng}$ dynasty, for the period of 1559-1912 CE, as a sequel of the series of works surveying historical sunspot and aurora records, and providing online data to the scientific community regarding the attained results. In total of this ${\\it Q\\bar{\\imath}ngsh\\check{\\imath}ga\\check{o}}$ survey, we found 111 records of night-sky luminous events with the keywords such as vapor (${\\it q\\grave{\\imath}}$), cloud (${\\it y\\acute{u}n}$), and light (${\\it gu\\bar{a}ng}$), which may indicate auroras as well as some other phenomena. Similarly keyword survey for sunspots were done, but no sunspot record was found. In comparison with the aurora records in the western world, we found 14 of the 111 records have a corresponding record of simultaneous observation in the western world and hence are very likely to be aurora. In order to investigate the likeliness of the rest of ...

  10. A simulation study of the current-voltage relationship of the Io tail aurora

    Science.gov (United States)

    Matsuda, K.; Terada, N.; Katoh, Y.; Misawa, H.

    2012-10-01

    The Io tail aurora extends for approximately 100 degrees downstream in longitude from the Io footprint aurora. Observations indicate that the brightness of the Io tail aurora continuously decreases along the footpath while its peak altitude remains constant. According to the quasi-steady theoretical frame, this suggests that the field-aligned voltage is constant while the parallel current density decreases in the downstream direction. The mechanism that realizes the current-voltage relationship of the Io tail aurora remains unresolved. In this paper, we apply a new multimagnetofluid code to the Io-Jupiter system to clarify the origin of the current-voltage relationship. The code solves a set of equations that includes the electron convection term in Ohm's law, which enables us to simulate the current-driven ion acoustic instability in the fluid frame. The instability forms a transition layer at a high altitude, which accelerates the magnetospheric electrons and blocks the magnetospheric ions, leading to the formation of a density depleted region called an auroral cavity. We find that if the ionospheric proton density decreases at the same rate as the parallel current density, the timescale on which the transition layer disappears is consistent with the longitudinal extent of the tail aurora, and the potential gap is constant all along the tail. We discuss the possibility that the fringe, wideband repetitive bursts of the Io-related Jovian decametric radiation, is excited in the auroral cavity.

  11. Syncrude's Aurora Mine : the key to future Athabasca oil sands development

    International Nuclear Information System (INIS)

    Syncrude's newest mine, the Aurora mine is located 35 km northeast of Syncrude's existing Mildred Lake plant, across the Athabasca River. It has a potential to produce more than 2.5 billion barrels of bitumen. Aurora will eventually consist of two surface mines, the Aurora North and Aurora South. Mining and extraction will occur at Aurora with the resulting bitumen transported as a froth by pipeline back to the existing plant for upgrading to Syncrude Sweet Blend. A total of 120 km of pipeline will be used. Syncrude has developed a new method of sending oilsand from its Athabasca deposit to the extraction plant. The company plans to phase out the dragline, bucketwheel reclaimer, and conveyor ore mining and delivery system in favour of shovel, truck, and hydrotransport technology. The advantages of hydrotransport include significant energy savings and considerably less plant infrastructure. A hydrotransport prototype is at work at Syncrude's base mine where it is responsible for 15 per cent of the production

  12. Syncrude`s Aurora Mine : the key to future Athabasca oil sands development

    Energy Technology Data Exchange (ETDEWEB)

    Kershaw, D. [Syncrude Canada Ltd., Edmonton, AB (Canada)

    1998-09-01

    Syncrude`s newest mine, the Aurora mine is located 35 km northeast of Syncrude`s existing Mildred Lake plant, across the Athabasca River. It has a potential to produce more than 2.5 billion barrels of bitumen. Aurora will eventually consist of two surface mines, the Aurora North and Aurora South. Mining and extraction will occur at Aurora with the resulting bitumen transported as a froth by pipeline back to the existing plant for upgrading to Syncrude Sweet Blend. A total of 120 km of pipeline will be used. Syncrude has developed a new method of sending oilsand from its Athabasca deposit to the extraction plant. The company plans to phase out the dragline, bucketwheel reclaimer, and conveyor ore mining and delivery system in favour of shovel, truck, and hydrotransport technology. The advantages of hydrotransport include significant energy savings and considerably less plant infrastructure. A hydrotransport prototype is at work at Syncrude`s base mine where it is responsible for 15 per cent of the production.

  13. Estrogen-Induced Aurora Kinase-A (AURKA) Gene Expression is Activated by GATA-3 in Estrogen Receptor-Positive Breast Cancer Cells

    OpenAIRE

    Jiang, Shoulei; Katayama, Hiroshi; Jin WANG; Li, Sara Antonia; Hong, Yan; Radvanyi, Laszlo; Li, Jonathan J.; Sen, Subrata

    2010-01-01

    Aurora-A is a proto-oncogenic mitotic kinase that is frequently overexpressed in human epithelial malignancies including in breast and ovarian cancers. The mechanism of transcriptional upregulation of Aurora-A in human breast cancer is not yet elucidated. We report herein that Aurora-A transcription is positively regulated by GATA-3 in response to estrogen in estrogen receptor α (ERα)-positive cells. Transient expression of aurora-A promoter deletion mutants in luciferase constructs identifie...

  14. Two Universities and Two Eras of Catholicism in China: Fu Jen University and Aurora University, 1903-1937

    Science.gov (United States)

    Xian, Liu

    2009-01-01

    This paper compares Fu Jen University in Beijing and Aurora University in Shanghai--the two comprehensive Catholic universities located in the two largest cities of China in modern history--and analyzes four aspects: identity, educational idea, curriculum, and campus culture. It was found that the differences between Aurora and Fu Jen resulted…

  15. Signatures in the dayside aurora of plasma transfer from the magnetosheath

    International Nuclear Information System (INIS)

    Continuous ground-based observations of the dayside aurora provide important information, complementary to the in situ measurements from satellites, on plasma transport and electromagnetic coupling between the magnetosheath and the magnetosphere. In this study observations of the polar cusp/dayside oval aurora from Svalbard,Norway, simultaneous observations of the nightside aurora from Poker Flat, Alaska, and the interplanetary magnetic field from satellites, are used to identify the ionospheric signatures of plasma transfer from the solar wind to the magnetosphere. The characteristics of motion, spatial scale, time of duration and repetition frequency of certain dayside auroral forms which occur at the time of large-scale oval expansions (IMF Bsub(z) < 0), are observed to be consistent with the expected optical signatures of plasma transfer through the dayside magnetopause boundary layer, in association with flux transfer events. Similarly, more large-scale (time and space) events are tentatively explained by the quasi steady-state reconnection process

  16. Function and regulation of Aurora/Ipl1p kinase family in cell division

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    During mitosis, the parent cell distributes its genetic materials equally into two daughter cells through chromosome segregation, a complex movements orchestrated by mitotic kinases and its effector proteins.Faithful chromosome segregation and cytokinesis ensure that each daughter cell receives a full copy of genetic materials of parent cell. Defects in these processes can lead to aneuploidy or polyploidy. Aurora/Ipl1p fanily,a class of conserved serine/threonine kinases, plays key roles in chromosome segregation and cytokinesis.This article highlights the function and regulation of Aurora/Ipl1p family in mitosis and provides potential links between aberrant regulation of Aurora/Ipl1p kinases and pathogenesis of human cancer.

  17. A High Resolution Magnetohydrodynamic Simulation Study of Kronian Field-Aligned Currents and Aurora

    Science.gov (United States)

    Fukazawa, K.; Ogino, T.; Walker, R. J.

    2011-12-01

    Magnetohydrodynamic simulations of the interaction of Saturn's magnetosphere with the solar wind indicate that Kelvin-Helmholtz (K-H) waves can form on the dayside magnetopause when the interplanetary magnetic field (IMF) is northward. Dayside magnetic reconnection occurs at Saturn for northward IMF. The combination of K-H waves and reconnection caused enhanced vorticity in Saturn's magnetosphere. We have used a very high resolution version (grid interval is 0.1 RS) of our simulation code to study the consequences of the vortices and reconnection for the generation of field aligned currents (FAC) and aurorae in Saturn's ionosphere. We found three bands of alternating FAC toward and away from the dawn side of the ionosphere and two sets on the dusk side. The K-H waves generated a series of toward and away currents along the dayside side magnetopause. In the ionosphere they appear as a series of spots of up and down current. The K-H field aligned currents are adjacent to nearly continuous currents located from 1600 LT around past midnight to about 0700 LT The largest currents (jpara> 5×10-8 A /m-2) are found are at the highest latitudes. They map to the magnetopause and to the near-Earth tail region. In analogy with the Earth's ionosphere the field aligned currents away from Saturn can serve as a proxy for discrete aurorae. We used the away current density and the Knight relationship to estimate the energy flux from discrete aurorae and obtained ~1 mW /m-2 in the region with the strongest currents. Similar energy fluxes were found in the K-H related aurorae. This gave approximately 70 GW for the auroral power. We also investigated diffuse aurorae by using the energy flux in the absence of the field aligned currents. We found a region of enhanced thermal energy flux in the region where cusp aurorae are observed.

  18. A review of East Asian reports of aurorae and comets circa AD 775

    Science.gov (United States)

    Chapman, J.; Neuhäuser, D. L.; Neuhäuser, R.; Csikszentmihalyi, M.

    2015-08-01

    Given that a strong 14C variation in AD 775 has recently been suggested to be due to the largest solar flare ever recorded in history, it is relevant to investigate whether celestial events observed around that time may have been aurorae, possibly even very strong aurorae, or otherwise related to the 14C variation (e.g. a suggested comet impact with Earth's atmosphere). We critically review several celestial observations from AD 757 to the end of the 770s, most of which were previously considered to be true, and in some cases, strong aurorae; we discuss in detail the East Asian records and their wording. We conclude that probably none among the events after AD 770 was actually an aurora, including the event in AD 776 Jan, which was misdated for AD 774 or 775; the observed white qi phenomenon that happened above the moon in the south-east was most probably a halo effect near the full Moon - too late in any case to be related to the 14C variation in AD 774/5. There is another report of a similar (or identical) white qi phenomenon above the moon, reported just before a comet observation and dated to AD 776 Jan; the reported comet observed by the Chinese was misdated to AD 776, but actually sighted in AD 767. Our critical review of East Asian reports of aurorae circa AD 775 shows some very likely true Chinese auroral displays observed and reported for AD 762; there were also several events prior to AD 771 that may have been aurorae but are questionable.

  19. Europa's far ultraviolet oxygen aurora from a comprehensive set of HST observations

    Science.gov (United States)

    Roth, Lorenz; Saur, Joachim; Retherford, Kurt D.; Strobel, Darrell F.; Feldman, Paul D.; McGrath, Melissa A.; Spencer, John R.; Blöcker, Aljona; Ivchenko, Nickolay

    2016-03-01

    We analyze a large set of far ultraviolet oxygen aurora images of Europa's atmosphere taken by Hubble's Space Telescope Imaging Spectrograph (HST/STIS) in 1999 and on 19 occasions between 2012 and 2015. We find that both brightness and aurora morphology undergo systematic variations correlated to the periodically changing plasma environment. The time variable morphology seems to be strongly affected by Europa's interaction with the magnetospheric plasma. The brightest emissions are often found in the polar region where the ambient Jovian magnetic field line is normal to Europa's disk. Near the equator, where bright spots are found at Io, Europa's aurora is faint suggesting a general difference in how the plasma interaction shapes the aurora at Io and Europa. The dusk side is consistently brighter than the dawnside with only few exceptions, which cannot be readily explained by obvious plasma physical or known atmospheric effects. Brightness ratios of the near-surface OI] 1356 Što OI 1304 Šemissions between 1.5 and 2.8 with a mean ratio of 2.0 are measured, confirming that Europa's bound atmosphere is dominated by O2. The 1356/1304 ratio decreases with increasing altitude in agreement with a more extended atomic O corona, but O2 prevails at least up to altitudes of ˜900 km. Differing 1356/1304 line ratios on the plasma upstream and downstream hemispheres are explained by a differing O mixing ratio in the near-surface O2 atmosphere of ˜5% (upstream) and ≲1% (downstream), respectively. During several eclipse observations, the aurora does not reveal any signs of systematic changes compared to the sunlit images suggesting no or only weak influence of sunlight on the aurora and an optically thin atmosphere.

  20. Aurora-A overexpression enhances cell-aggregation of Ha-ras transformants through the MEK/ERK signaling pathway

    International Nuclear Information System (INIS)

    Overexpression of Aurora-A and mutant Ras (RasV12) together has been detected in human bladder cancer tissue. However, it is not clear whether this phenomenon is a general event or not. Although crosstalk between Aurora-A and Ras signaling pathways has been reported, the role of these two genes acting together in tumorigenesis remains unclear. Real-time PCR and sequence analysis were utilized to identify Ha- and Ki-ras mutation (Gly -> Val). Immunohistochemistry staining was used to measure the level of Aurora-A expression in bladder and colon cancer specimens. To reveal the effect of overexpression of the above two genes on cellular responses, mouse NIH3T3 fibroblast derived cell lines over-expressing either RasV12and wild-type Aurora-A (designated WT) or RasV12 and kinase-inactivated Aurora-A (KD) were established. MTT and focus formation assays were conducted to measure proliferation rate and focus formation capability of the cells. Small interfering RNA, pharmacological inhibitors and dominant negative genes were used to dissect the signaling pathways involved. Overexpression of wild-type Aurora-A and mutation of RasV12 were detected in human bladder and colon cancer tissues. Wild-type Aurora-A induces focus formation and aggregation of the RasV12 transformants. Aurora-A activates Ral A and the phosphorylation of AKT as well as enhances the phosphorylation of MEK, ERK of WT cells. Finally, the Ras/MEK/ERK signaling pathway is responsible for Aurora-A induced aggregation of the RasV12 transformants. Wild-type-Aurora-A enhances focus formation and aggregation of the RasV12 transformants and the latter occurs through modulating the Ras/MEK/ERK signaling pathway

  1. Unidentified emission lines in Jupiter's northern and southern 2 micron aurorae

    International Nuclear Information System (INIS)

    The detection of a number of unidentified emission lines in Jupiter's 2 micron spectral region for both the northern and southern aurorae is reported. Spectra taken as far back as September 1987 show that at least some of these features are long-lived. Some emission features are present in both the aurorae while others appear to reside only in one or the other. Certain emission lines are detected only at low latitudes. Altogether, two or more species besides H2 are inferred. 13 refs

  2. BOOK REVIEW: Electron acceleration in the aurora and beyond

    Science.gov (United States)

    McClements, K. G.

    1999-08-01

    Duncan Bryant is a retired space plasma physicist who spent most of his career at the Rutherford-Appleton Laboratory in Oxfordshire, England. For many years he has been challenging a widely accepted theory, that auroral electrons are accelerated by double layers, on the grounds that it contains a fundamental error (allegedly, an implicit assumption that charged particles can gain energy from conservative fields). It is, of course, right that models of particle acceleration in natural plasmas should be scrutinized carefully in terms of their consistency with basic physical principles, and I believe that Dr Bryant has performed a valuable service by highlighting this issue. He maintains that auroral electron acceleration by double layers is fundamentally untenable, and that acceleration takes place instead via resonant interactions with lower hybrid waves. In successive chapters, he asserts that essentially the same process can account for electron acceleration observed at the Earth's bow shock, in the neighbourhood of an `artificial comet' produced as part of the Active Magnetospheric Particle Explorers (AMPTE) space mission in 1984/85, in the solar wind, at the Earth's magnetopause, and in the Earth's magneto- sphere. The evidence for this is not always convincing: waves with frequencies of the order of the lower hybrid resonance are often observed in these plasma environments, but in general it is difficult to identify clearly which wave mode is being observed (whistlers, for example, have frequencies in approximately the same range as lower hybrid waves). Moreover, it is not at all clear that the waves which are observed, even if they were of the appropriate type, would have sufficient intensity to accelerate electrons to the extent observed. The author makes a persuasive case, however, that acceleration in the aurora, and in other plasma environments accessible to in situ measurements, involves some form of wave turbulence. In Chapter 2 it is pointed out that

  3. Preliminary Results from a Coordinated Hisaki/Chandra/XMM-Newton Study of the Jovian Aurora and Io Plasma Torus

    Science.gov (United States)

    Kraft, Ralph; Kimura, Tomoki; Elsner, Ronald; Branduardi-Raymont, Graziella; Gladstone, Randy; Badman, Sarah Victoria; Ezoe, Yuichiro; Murakami, Go; Murray, Stephen S.; Roediger, Elke; Tsuchiya, Fuminori; Yamazaki, Atsushi; Yoshikawa, Ichiro; Yoshioka, Kazuo

    2014-01-01

    We present preliminary results from a coordinated Hisaki/Chandra/XMM-Newton observational campaign of the Jovian aurora and Io plasma torus. The data were taken over a three week period in April, 2014. Jupiter was observed continuously with Hisaki, six times with the Chandra/HRC instrument for roughly 12 hours per observation, and twice by XMM-Newton. The goal of this observational campaign was to understand how energy and matter are exchanged between the Jovian aurora, the IPT, and the Solar wind. X-ray observations provide key diagnostics on highly stripped ions and keV electrons in the Jovian magnetosphere. We use the temporal, spatial, and spectral capabilities of the three instruments to search for correlated variability between the Solar wind, the EUV-emitting plasma of the IPT and UV aurora, and the ions responsible for the X-ray aurora. Preliminary analysis suggests a strong 45 min periodicity in the EUV emission from the electron aurora. There is some evidence for complex variability of the X-ray auroras on scales of tens of minutes. There is also clear morphological changes in the X-ray aurora that do not appear to be correlated with either variations in the IPT or Solar wind.

  4. Aurora A kinase regulates proper spindle positioning in C. elegans and in human cells.

    Science.gov (United States)

    Kotak, Sachin; Afshar, Katayon; Busso, Coralie; Gönczy, Pierre

    2016-08-01

    Accurate spindle positioning is essential for error-free cell division. The one-cell Caenorhabditis elegans embryo has proven instrumental for dissecting mechanisms governing spindle positioning. Despite important progress, how the cortical forces that act on astral microtubules to properly position the spindle are modulated is incompletely understood. Here, we report that the PP6 phosphatase PPH-6 and its associated subunit SAPS-1, which positively regulate pulling forces acting on spindle poles, associate with the Aurora A kinase AIR-1 in C. elegans embryos. We show that acute inactivation of AIR-1 during mitosis results in excess pulling forces on astral microtubules. Furthermore, we uncover that AIR-1 acts downstream of PPH-6-SAPS-1 in modulating spindle positioning, and that PPH-6-SAPS-1 negatively regulates AIR-1 localization at the cell cortex. Moreover, we show that Aurora A and the PP6 phosphatase subunit PPP6C are also necessary for spindle positioning in human cells. There, Aurora A is needed for the cortical localization of NuMA and dynein during mitosis. Overall, our work demonstrates that Aurora A kinases and PP6 phosphatases have an ancient function in modulating spindle positioning, thus contributing to faithful cell division. PMID:27335426

  5. Polo‐like kinase 1 and Aurora A cooperate in spindle assembly during meiotic

    Czech Academy of Sciences Publication Activity Database

    Böhmová, Tereza; Mayer, Alexandra; Šolc, Petr; Baran, Vladimír; Motlík, Jan

    Liběchov : Institute of Animal Physiology and Genetics AS CR, v.v ,, 2010. s. 52-52. [Czech-Japan Joint Symposium for Animal Reproduction. 20.09.2010-21.09.2010, Liblice] Institutional research plan: CEZ:AV0Z50450515 Keywords : Polo-like kinase 1 * Aurora A * mouse oocytes Subject RIV: EB - Genetics ; Molecular Biology

  6. 76 FR 65216 - Beacon Medical Services, LLC, Aurora, CO; Notice of Negative Determination Regarding Application...

    Science.gov (United States)

    2011-10-20

    ... (76 FR 40401). The workers of Beacon Medical Services are engaged in activities related ] to the... Employment and Training Administration Beacon Medical Services, LLC, Aurora, CO; Notice of Negative... apply for Trade Adjustment Assistance (TAA) applicable to workers and former workers of Beacon...

  7. Control of Jupiter's Radio Emission and Aurorae by the Solar Wind

    Science.gov (United States)

    Gurnett, D. A.; Kurth, W. S.; Hospodarsky, G. B.; Persoon, A. M.; Zarka, P.; Lecacheux, A.; Bolton, S. J.; Desch, . D.; Farrell, W. W.; Kaiser, M. L.

    2002-01-01

    Radio emissions from Jupiter provided the first evidence that this giant planet has a strong magnetic field and a large magnetosphere. Jupiter also has polar aurorae, which are similar in many respects to Earth's aurorae. The radio emissions are believed to be generated along the high-latitude magnetic field lines by the same electrons that produce the aurorae, and both the radio emission in the hectometric frequency range and the aurorae vary considerably. The origin of the variability, however, has been poorly understood. Here we report simultaneous observations using the Cassini and Galileo spacecraft of hectometric radio emissions and extreme ultraviolet auroral emissions from Jupiter. Our results show that both of these emissions are triggered by interplanetary shocks propagating outward from the Sun. When such a shock arrives at Jupiter, it seems to cause a major compression and reconfiguration of the magnetosphere, which produces strong electric fields and therefore electron acceleration along the auroral field lines, similar to the processes that occur during geomagnetic storms at the Earth.

  8. Magnetospherically driven optical and radio aurorae at the end of the stellar main sequence.

    Science.gov (United States)

    Hallinan, G; Littlefair, S P; Cotter, G; Bourke, S; Harding, L K; Pineda, J S; Butler, R P; Golden, A; Basri, G; Doyle, J G; Kao, M M; Berdyugina, S V; Kuznetsov, A; Rupen, M P; Antonova, A

    2015-07-30

    Aurorae are detected from all the magnetized planets in our Solar System, including Earth. They are powered by magnetospheric current systems that lead to the precipitation of energetic electrons into the high-latitude regions of the upper atmosphere. In the case of the gas-giant planets, these aurorae include highly polarized radio emission at kilohertz and megahertz frequencies produced by the precipitating electrons, as well as continuum and line emission in the infrared, optical, ultraviolet and X-ray parts of the spectrum, associated with the collisional excitation and heating of the hydrogen-dominated atmosphere. Here we report simultaneous radio and optical spectroscopic observations of an object at the end of the stellar main sequence, located right at the boundary between stars and brown dwarfs, from which we have detected radio and optical auroral emissions both powered by magnetospheric currents. Whereas the magnetic activity of stars like our Sun is powered by processes that occur in their lower atmospheres, these aurorae are powered by processes originating much further out in the magnetosphere of the dwarf star that couple energy into the lower atmosphere. The dissipated power is at least four orders of magnitude larger than what is produced in the Jovian magnetosphere, revealing aurorae to be a potentially ubiquitous signature of large-scale magnetospheres that can scale to luminosities far greater than those observed in our Solar System. These magnetospheric current systems may also play a part in powering some of the weather phenomena reported on brown dwarfs. PMID:26223623

  9. Aurora T: a Monte Carlo code for transportation of neutral atoms in a toroidal plasma

    International Nuclear Information System (INIS)

    This paper contains a short description of Aurora code. This code have been developed at Princeton with Monte Carlo method for calculating neutral gas in cylindrical plasma. In this work subroutines such one can take in account toroidal geometry are developed

  10. Energetic electron precipitation associated with pulsating aurora: EISCAT and Van Allen Probe observations

    Czech Academy of Sciences Publication Activity Database

    Miyoshi, Y.; Oyama, S.; Saito, S.; Kurita, S.; Fujiwara, H.; Kataoka, R.; Ebihara, Y.; Kletzing, C.; Reeves, G.; Santolík, Ondřej; Clilverd, M.; Rodger, C. J.; Turunen, E.; Tsuchiya, F.

    2015-01-01

    Roč. 120, č. 4 (2015), s. 2754-2766. ISSN 2169-9380 Institutional support: RVO:68378289 Keywords : pulsating aurora * EISCAT * Van Allen Probes * pitch angle scattering Subject RIV: BN - Astronomy, Celestial Mechanics, Astrophysics Impact factor: 3.440, year: 2013 http://onlinelibrary.wiley.com/doi/10.1002/2014JA020690/abstract

  11. Cancer Cell Resistance to Aurora Kinase Inhibitors: Identification of Novel Targets for Cancer Therapy

    Czech Academy of Sciences Publication Activity Database

    Hrabáková, Rita; Kollaredy, M.; Tylečková, Jiřina; Halada, Petr; Hajdúch, M.; Gadher, S. J.; Kovářová, Hana

    2013-01-01

    Roč. 12, č. 1 (2013), s. 455-469. ISSN 1535-3893 R&D Projects: GA MŠk LC07017 Institutional support: RVO:67985904 ; RVO:61388971 Keywords : Aurora kinase inhibitors * resistance * p53 * apoptosis Subject RIV: CE - Biochemistry Impact factor: 5.001, year: 2013

  12. A review of East Asian reports of aurorae and comets circa AD 775

    CERN Document Server

    Chapman, Jesse; Neuhaeuser, Ralph; Csikszentmihalyi, Mark

    2015-01-01

    Given that a strong 14C variation in AD 775 has recently been suggested to be due to the largest solar flare ever recorded in history, it is relevant to investigate whether celestial events observed around that time may have been aurorae, possibly even very strong aurorae, or otherwise related to the 14C variation (e.g. a suggested comet impact with Earth's atmosphere). We critically review several celestial observations from AD 757 to the end of the 770s, most of which were previously considered to be true, and in some cases, strong aurorae; we discuss in detail the East Asian records and their wording. We conclude that probably none among the events after AD 770 was actually an aurora, including the event in AD 776 Jan, which was misdated for AD 774 or 775; the observed white qi phenomenon that happened "above the moon" in the south-east was most probably a halo effect near the full moon - too late in any case to be related to the 14C variation in AD 774/5. There is another report of a similar (or identical...

  13. Allosteric inhibition of Aurora-A kinase by a synthetic vNAR domain.

    Science.gov (United States)

    Burgess, Selena G; Oleksy, Arkadiusz; Cavazza, Tommaso; Richards, Mark W; Vernos, Isabelle; Matthews, David; Bayliss, Richard

    2016-07-01

    The vast majority of clinically approved protein kinase inhibitors target the ATP-binding pocket directly. Consequently, many inhibitors have broad selectivity profiles and most have significant off-target effects. Allosteric inhibitors are generally more selective, but are difficult to identify because allosteric binding sites are often unknown or poorly characterized. Aurora-A is activated through binding of TPX2 to an allosteric site on the kinase catalytic domain, and this knowledge could be exploited to generate an inhibitor. Here, we generated an allosteric inhibitor of Aurora-A kinase based on a synthetic, vNAR single domain scaffold, vNAR-D01. Biochemical studies and a crystal structure of the Aurora-A/vNAR-D01 complex show that the vNAR domain overlaps with the TPX2 binding site. In contrast with the binding of TPX2, which stabilizes an active conformation of the kinase, binding of the vNAR domain stabilizes an inactive conformation, in which the αC-helix is distorted, the canonical Lys-Glu salt bridge is broken and the regulatory (R-) spine is disrupted by an additional hydrophobic side chain from the activation loop. These studies illustrate how single domain antibodies can be used to characterize the regulatory mechanisms of kinases and provide a rational basis for structure-guided design of allosteric Aurora-A kinase inhibitors. PMID:27411893

  14. Aurora: Los Alamos multikilojoule angular-multiplexed KrF driver prototype for ICF

    International Nuclear Information System (INIS)

    The Los Alamos National Laboratory (LANL) has participated in programs to apply high-power gas lasers to inertial confinement fusion (ICF). The bulk of this effort has been in the development of CO/sub 2/ laser systems and laser-plasma interaction experiments at a 10.6-μm wavelength. The main hardware element in this program is the Aurora KrF laser system, which is a prototype for using optical angular multiplexing and serial amplification by large electron-beam-driven KrF laser amplifiers to study KrF systems as potential fusion drivers. Aurora will serve as a test-bed for specific laser, optical, and electron-beam-pumping technology aspects of larger KrF fusion systems. The Aurora system is being built in two phases. The first-phase portion of the Aurora system contains all the main optical and laser elements from the front end to the final amplifier output. In the first phase, the front end output is replicated using aperture slicers and beam splitters to produce a 480-ns long pulse train consisting of 96 separate 5-ns pulses. This pulse train is encoded in angular separation, relayed through the amplifier chain by means of the centered optical system and the computer-controlled alignment station, and delivered to a diagnostic station which follows the main power amplifier [large aperture module (LAM)]. The second phase of the system contains the first-phase portion and the additional optical and target hardware needed to stack 48 of the 96 multiplexed and amplified beams into a single multikilojoule 5-ns pulse at the fusion target. The authors give a description of the Aurora system and discuss its present status

  15. Design and performance of large area monolithic electron guns for the Aurora KrF laser system

    International Nuclear Information System (INIS)

    Aurora is an inertial confinement fusion laser system using optical angular multiplexing and a chain of four cold cathode electron beam driven KrF laser amplifiers to produce 10 to 20 kJ of optical energy

  16. Daurinol Enhances the Efficacy of Radiotherapy in Lung Cancer via Suppression of Aurora Kinase A/B Expression.

    Science.gov (United States)

    Woo, Jong Kyu; Kang, Ju-Hee; Shin, DongYun; Park, Seong-Hyeok; Kang, Kyungsu; Nho, Chu Won; Seong, Je Kyung; Lee, Sang-Jin; Oh, Seung Hyun

    2015-07-01

    The aurora kinases constitute one family of serine/threonine kinases whose activity is essential for mitotic progression. The aurora kinases are frequently upregulated in human cancers and are associated with sensitivity to chemotherapy in certain ones. In the present study, we investigated whether aurora kinases could be a target to overcome radioresistance or enhance the radiosensitivity of lung cancer. For that purpose, we determined the therapeutic potential of daurinol, an investigational topoisomerase inhibitor, alone and in combination with radiation, by observing its effect on aurora kinases. Daurinol decreased cell viability and proliferation in human colon and lung cancer cells. Gene expression in daurinol-treated human colon cancer cells was evaluated using RNA microarray. The mRNA expression of 18 genes involved in the mitotic spindle check point, including aurora kinase A (AURKA) and aurora kinase B (AURKB), was decreased in daurinol-treated human colon cancer cells as compared with vehicle-treated cells. As expected, radiation increased expression levels of AURKA and AURKB. This increase was effectively attenuated by siRNAs against AURKA and AURKB, which suppressed cell growth and increased apoptosis under radiation. Furthermore, the expression of AURKA and AURKB was suppressed by daurinol in the presence or absence of radiation in colon and lung cancer cells. Daurinol alone or in combination with radiation decreased lung cancer growth in xenograft mouse models. Our data clearly confirm the antitumor and radiosensitizing activity of daurinol in human lung cancer cells through the inhibition of AURKA and AURKB. PMID:25882311

  17. Targeting the interaction of Aurora kinases and SIRT1 mediated by Wnt signaling pathway in colorectal cancer: A critical review.

    Science.gov (United States)

    Subramaniyan, Boopathi; Jagadeesan, Kaviya; Ramakrishnan, Sabitha; Mathan, Ganeshan

    2016-08-01

    The Aurora kinases belong to the family of serine/threonine kinase, a central regulator of mitosis and their expression increased during G2/M phase. It is classified into Aurora A, B and C, each has distinct roles in cellular processes, which includes regulation of spindle assembly, function of centrosomes, cytoskeleton and cytokinesis. During cancer growth, their rapid increase makes most attractive marker for cancer treatment at present. However Aurora A kinase is known to be a marker for cancer therapy, the most important serine/threonine kinase of Aurora B kinase involvement in cancer is still inadequate. Subsequently, the recent findings revealed that the class III histone deacetylase of SIRT1 is a key regulator to activate Aurora kinases from S phase damaged DNA through Wnt signaling pathway. Even if both Aurora A kinase and SIRT1 serve as a marker for cancer therapy, the present review reveals it is interaction in Wnt signaling pathway that solely for colorectal cancer. PMID:27470380

  18. Aurora multikilojoule KrF laser system prototype for inertial confinement fusion

    International Nuclear Information System (INIS)

    Aurora is the Los Alamos National Laboratory short-pulse, high-power, KrF laser system. It serves as an end-to-end technology demonstration for large-scale ultraviolet laser systems of interest for short wavelength, inertial confinement fusion (ICF) investigations. The systems is a prototype for using optical angular multiplexing and serial amplification by large electron-beam-driven KrF laser amplifiers to deliver stacked, 248-nm, 5-ns duration multikilojoule laser pulses to ICF targets using an --1-km-long optical beam path. The entire Aurora KrF laser system is described and the design features of the following major system components are summarized: front-end lasers, amplifier train, multiplexer, optical relay train, demultiplexer, target irradiation apparatus, and alignment and controls systems

  19. Magnetospherically driven optical and radio aurorae at the end of the stellar main sequence

    CERN Document Server

    Hallinan, G; Cotter, G; Bourke, S; Harding, L K; Pineda, J S; Butler, R P; Golden, A; Basri, G; Doyle, J G; Kao, M M; Berdyugina, S V; Kuznetsov, A; Rupen, M P; Antonova, A

    2015-01-01

    Aurorae are detected from all the magnetized planets in our Solar System, including Earth. They are powered by magnetospheric current systems that lead to the precipitation of energetic electrons into the high-latitude regions of the upper atmosphere. In the case of the gas-giant planets, these aurorae include highly polarized radio emission at kilohertz and megahertz frequencies produced by the precipitating electrons, as well as continuum and line emission in the infrared, optical, ultraviolet and X-ray parts of the spectrum, associated with the collisional excitation and heating of the hydrogen-dominated atmosphere. Here we report simultaneous radio and optical spectroscopic observations of an object at the end of the stellar main sequence, located right at the boundary between stars and brown dwarfs, from which we have detected radio and optical auroral emissions both powered by magnetospheric currents. Whereas the magnetic activity of stars like our Sun is powered by processes that occur in their lower a...

  20. Dynamic phosphorylation of Histone Deacetylase 1 by Aurora kinases during mitosis regulates zebrafish embryos development.

    Science.gov (United States)

    Loponte, Sara; Segré, Chiara V; Senese, Silvia; Miccolo, Claudia; Santaguida, Stefano; Deflorian, Gianluca; Citro, Simona; Mattoscio, Domenico; Pisati, Federica; Moser, Mirjam A; Visintin, Rosella; Seiser, Christian; Chiocca, Susanna

    2016-01-01

    Histone deacetylases (HDACs) catalyze the removal of acetyl molecules from histone and non-histone substrates playing important roles in chromatin remodeling and control of gene expression. Class I HDAC1 is a critical regulator of cell cycle progression, cellular proliferation and differentiation during development; it is also regulated by many post-translational modifications (PTMs). Herein we characterize a new mitosis-specific phosphorylation of HDAC1 driven by Aurora kinases A and B. We show that this phosphorylation affects HDAC1 enzymatic activity and it is critical for the maintenance of a proper proliferative and developmental plan in a complex organism. Notably, we find that Aurora-dependent phosphorylation of HDAC1 regulates histone acetylation by modulating the expression of genes directly involved in the developing zebrafish central nervous system. Our data represent a step towards the comprehension of HDAC1 regulation by its PTM code, with important implications in unravelling its roles both in physiology and pathology. PMID:27458029

  1. Time sequence analysis of flickering auroras. I - Application of Fourier analysis. [in atmosphere

    Science.gov (United States)

    Berkey, F. T.; Silevitch, M. B.; Parsons, N. R.

    1980-01-01

    Using a technique that enables one to digitize the brightness of auroral displays from individual fields of a video signal, we have analyzed the frequency content of flickering aurora. Through the application of Fourier analysis to our data, we have found that flickering aurora contains a wide range of enhanced frequencies, although the dominant frequency enhancement generally occurs in the range 6-12 Hz. Each incidence of flickering that we observed was associated with increased radio wave absorption. Furthermore, we have found that flickering occurs in bright auroral surges, the occurrence of which is not limited to the 'breakup' phase of auroral substorms. Our results are interpreted in terms of a recently proposed theory of fluctuating double layers that accounts for a number of the observational features.

  2. Phase-locked coaxial reflex diodes for Aurora and other drivers

    Science.gov (United States)

    Phelps, David A.

    1990-04-01

    High power microwave (11PM) experiments with Aurora reflex diodes (ARDs) are analyzed. In particular the multi-wave guide logistics 11PM peak envelope power (PEP) and waveform consistency problems associated with multi-guide radial extraction are reviewed. A novel design involving an outer coaxial cavity to extract power from the ARD cavity via 2535 appropriately placed ports or an equivalently loaded peripheral opening (sideshoot aperture) is described. Tmproved extraction mode selection phase locking frequency stabilization and waveform smoothing via this coaxial ARD (or CARD) is predicted. Staged physics studies and scaling experiments to validate the 11PM operation of a full-scale CARD on a Pocobeam and Aurora are recommended. 1.

  3. Status of the Aurora laser system: Angular-multiplexed multikilojoule krypton fluoride prototype for inertial fusion

    International Nuclear Information System (INIS)

    In this presentation, the authors report on the present status of the Aurora system including: The operation of the final stage 1-X 1-m laser at the 10-kJ level; the generation of 5-ns pulses by the front end; integration of the front end, multiplexer, amplifiers, and the extraction of long-pulse energy from the amplifier chain. Progress on the design and construction of the demultiplexer are also reported

  4. Localization of Aurorae with 10 m High Power Radar Technique, using a Rotating Antenna

    OpenAIRE

    Hellgren, Gösta; Meos, Johan

    2011-01-01

    The paper describes the 10 m high power recorder with a rotating antenna that is used since May 1951 for the localization of aurorae at the Radio Wave Propagation Laboratory of the Kiruna Geophysical Observatory (67.8° N, 20.5° E). Continuous observations during the time May 1951–March 1952 have disclosed periods of auroral activity. The preliminary results from these observations indicate that there is a good correlation between the auroral activity, the magnetic activity, and ...

  5. The budding yeast Ipl1/Aurora protein kinase regulates mitotic spindle disassembly

    OpenAIRE

    Buvelot, Stéphanie; Tatsutani, Sean Y.; Vermaak, Danielle; Biggins, Sue

    2003-01-01

    Ipl1p is the budding yeast member of the Aurora family of protein kinases, critical regulators of genomic stability that are required for chromosome segregation, the spindle checkpoint, and cytokinesis. Using time-lapse microscopy, we found that Ipl1p also has a function in mitotic spindle disassembly that is separable from its previously identified roles. Ipl1–GFP localizes to kinetochores from G1 to metaphase, transfers to the spindle after metaphase, and accumulates at the spindle midzone ...

  6. Sgo1 Regulates Both Condensin and Ipl1/Aurora B to Promote Chromosome Biorientation

    OpenAIRE

    Peplowska, K.; Wallek, A.; Storchova, Z.

    2014-01-01

    Correct chromosome segregation is essential in order to prevent aneuploidy. To segregate sister chromatids equally to daughter cells, the sisters must attach to microtubules emanating from opposite spindle poles. This so-called biorientation manifests itself by increased tension and conformational changes across kinetochores and pericentric chromatin. Tensionless attachments are dissolved by the activity of the conserved mitotic kinase Aurora B/Ipl1, thereby promoting the formation of correct...

  7. Bora and Aurora-A continue to activate Plk1 in mitosis

    Czech Academy of Sciences Publication Activity Database

    Bruinsma, W.; Macůrek, Libor; Freire, R.; Lindqvist, A.; Medema, R.H.

    2014-01-01

    Roč. 127, č. 4 (2014), s. 801-811. ISSN 0021-9533 R&D Projects: GA ČR GA13-18392S Grant ostatní: Ministerio de Economía y Competitividad(ES) SAF2010-22357; CONSOLIDER-Ingenio(NL) CDS2007-0015 Keywords : Aurora-A * Bora * Mitosis * Plk1 Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 5.432, year: 2014

  8. Effect of acidic lake water on survival of aurora trout (Salvelinus fontinalis) embryos and alevins

    Energy Technology Data Exchange (ETDEWEB)

    Snucins, E.J.; Liimatainen, V.A.; Gale, P.A.

    1988-01-01

    During the 1960s the aurora trout, a rare color variant of the brook trout, disappeared from its native waters in northeastern Ontario. Its disappearance was attributed to acidification of the waters by atmospheric deposition of industrial emissions from metal smelters at Sudbury, Ontario. Recently, water quality in the Sudbury area has improved due to emission reductions. These experiments were designed to assess the toxicity of current water quality in the native lakes of aurora trout. During May 1984, hatchery-reared aurora trout alevins were held for 4 days in 3 of their native lakes (Whiligig, Whitepine and Wilderness with pH 4.5-4.8) and a control lake, Regan Lake (pH 6.5), and survival rates were assessed. In a second bioassay, embryos and alevins were buried in the substrate at 3 groundwater upwelling sites, and survival rates were assessed. The final test involved a 14-day exposure of groundwater-reared fish to ambient conditions.

  9. Features of the polar cap aurorae in the southern polar region

    International Nuclear Information System (INIS)

    The data of the all-sky camera and photometer at Vostok station in the Antarctic nearpole region have been used for analysis of the auroral features in the southern polar cap. It is shown that the sun-aligned arcs appear in the polar cap with a delay-time of about an hour relative to the northward turning of the interplanetary magnetic field (IMF) and that they can remain for many hours provided the IMF is invariable. The distribution of these aurorae in the dayside polar cap displays a θ-shaped pattern which is clearly separated from the latitude-oriented arcs in the auroral oval. Disappearance of the sun-aligned arcs after the southward turning of the IMF occurs much faster: in 10-15 min. The observation of the polar cap arcs immersed in a wide band of diffuse luminescence implies that the sun-aligned arcs should be located within the θ-aurora transpolar band. It is concluded that the distribution of the aurorae in the polar cap, auroral oval and in the day-side cusp requires a closed structure for the magnetosphere. The convection pattern corresponding to a closed magnetosphere suggests the formation of closed cavities with a stagnation plasma regime in the distant tail of the magnetosphere. (author)

  10. Pulsating aurora observed on the ground and in-situ by the Van Allen Probes

    Science.gov (United States)

    Lessard, M.; Cohen, I. J.; Denton, R. E.; Engebretson, M. J.; Kletzing, C.; Wygant, J. R.; Bounds, S. R.; Smith, C. W.; MacDowall, R. J.; Kurth, W. S.

    2013-12-01

    Early observations and theory related to pulsating aurora suggested that the electrons that drive this aurora originate from the equatorial region of the magnetosphere and that a likely process that can scatter these electrons would involve chorus waves. Recent satellite observations during pulsating auroral events have provided important "firsts", including evidence of strong correlations between pulsating auroral patches and in-situ lower-band chorus (THEMIS), as well as correlations with energetic electron precipitation in the vicinity of geosynchronous orbit (GOES). These results provide important information regarding particle dynamics, leading to a question about how the chorus might be driven. We present observations of the Van Allen Probes in conjunction with a pulsating aurora event, as confirmed by observations on the ground. The in-situ data again show the presence of lower-band chorus. However, magnetic and electric field data also show that the wave bursts coincide with an apparent poloidal field-line resonance, begging the question of whether the resonance might be responsible for driving the VLF waves.

  11. Aurora B regulates formin mDia3 in achieving metaphase chromosome alignment.

    Science.gov (United States)

    Cheng, Lina; Zhang, Jiayin; Ahmad, Sana; Rozier, Lorene; Yu, Haiqian; Deng, Haiteng; Mao, Yinghui

    2011-03-15

    Proper bipolar attachment of sister kinetochores to the mitotic spindle is critical for accurate chromosome segregation in mitosis. Here we show an essential role of the formin mDia3 in achieving metaphase chromosome alignment. This function is independent of mDia3 actin nucleation activity, but is attributable to EB1-binding by mDia3. Furthermore, the microtubule binding FH2 domain of mDia3 is phosphorylated by Aurora B kinase in vitro, and cells expressing the nonphosphorylatable mDia3 mutant cannot position chromosomes at the metaphase plate. Purified recombinant mDia3 phosphorylated by Aurora B exhibits reduced ability to bind microtubules and stabilize microtubules against cold-induced disassembly in vitro. Cells expressing the phosphomimetic mDia3 mutant do not form stable kinetochore microtubule fibers; despite they are able to congress chromosomes to the metaphase plate. These findings reveal a key role for mDia3 and its regulation by Aurora B phosphorylation in achieving proper stable kinetochore microtubule attachment. PMID:21397845

  12. A compact SR light source for x-ray lithography 'AURORA'

    International Nuclear Information System (INIS)

    A compact synchrotron radiation (SR) light source called AURORA has been developed for industrial use. It is specially designed for X-ray lithography. AURORA consists of a storage ring, injector microtron and SR light beam lines. The storage ring is a superconducting single magnet machine, designed to accelerate a 150 MeV electron beam to 650 MeV and to store as high as 300 mA current. The injector is a racetrack microtron (RTM) producing a pulsed 150 MeV beam. As many as 16 SR light beam channels are available for AURORA. Prototypes of the storage ring and RTM are constructed, and beam commissioning is performed. A hundred and fifty MeV electron beam of a pulsed current 10 μA from the RTM is successfully injected to the ring and accelerated to 600 MeV and 10 mA current stored with a lifetime of more than 20 hours. The half-integer method investigated is shown to work well with the injection efficiency being found to be very high. Improvement of the design is now under way. (N.K.)

  13. Phosphorylation of CPAP by Aurora-A Maintains Spindle Pole Integrity during Mitosis.

    Science.gov (United States)

    Chou, En-Ju; Hung, Liang-Yi; Tang, Chieh-Ju C; Hsu, Wen-Bin; Wu, Hsin-Yi; Liao, Pao-Chi; Tang, Tang K

    2016-03-29

    CPAP is required for centriole elongation during S/G2 phase, but the role of CPAP in mitosis is incompletely understood. Here, we show that CPAP maintains spindle pole integrity through its phosphorylation by Aurora-A during mitosis. Depletion of CPAP induced a prolonged delay in mitosis, pericentriolar material (PCM) dispersion, and multiple mitotic abnormalities. Further studies demonstrated that CPAP directly interacts with and is phosphorylated by Aurora-A at serine 467 during mitosis. Interestingly, the dispersal of the PCM was effectively rescued by ectopic expression of wild-type CPAP or a phospho-mimic CPAP-S467D mutant, but not a non-phosphorylated CPAP-S467A mutant. Finally, we found that CPAP-S467D has a low affinity for microtubule binding but a high affinity for PCM proteins. Together, our results support a model wherein CPAP is required for proper mitotic progression, and phosphorylation of CPAP by Aurora-A is essential for maintaining spindle pole integrity. PMID:26997271

  14. Phosphorylation of CPAP by Aurora-A Maintains Spindle Pole Integrity during Mitosis

    Directory of Open Access Journals (Sweden)

    En-Ju Chou

    2016-03-01

    Full Text Available CPAP is required for centriole elongation during S/G2 phase, but the role of CPAP in mitosis is incompletely understood. Here, we show that CPAP maintains spindle pole integrity through its phosphorylation by Aurora-A during mitosis. Depletion of CPAP induced a prolonged delay in mitosis, pericentriolar material (PCM dispersion, and multiple mitotic abnormalities. Further studies demonstrated that CPAP directly interacts with and is phosphorylated by Aurora-A at serine 467 during mitosis. Interestingly, the dispersal of the PCM was effectively rescued by ectopic expression of wild-type CPAP or a phospho-mimic CPAP-S467D mutant, but not a non-phosphorylated CPAP-S467A mutant. Finally, we found that CPAP-S467D has a low affinity for microtubule binding but a high affinity for PCM proteins. Together, our results support a model wherein CPAP is required for proper mitotic progression, and phosphorylation of CPAP by Aurora-A is essential for maintaining spindle pole integrity.

  15. Inter-domain Cooperation in INCENP Promotes Aurora B Relocation from Centromeres to Microtubules

    Directory of Open Access Journals (Sweden)

    Armando van der Horst

    2015-07-01

    Full Text Available The chromosomal passenger complex is essential for error-free chromosome segregation and proper execution of cytokinesis. To coordinate nuclear division with cytoplasmic division, its enzymatic subunit, Aurora B, relocalizes from centromeres in metaphase to the spindle midzone in anaphase. In budding yeast, this requires dephosphorylation of the microtubule-binding (MTB domain of the INCENP analog Sli15. The mechanistic basis for this relocalization in metazoans is incompletely understood. We demonstrate that the putative coiled-coil domain within INCENP drives midzone localization of Aurora B via a direct, electrostatic interaction with microtubules. Furthermore, we provide evidence that the CPC multimerizes via INCENP’s centromere-targeting domain (CEN box, which increases the MTB affinity of INCENP. In (prometaphase, the MTB affinity of INCENP is outcompeted by the affinity of its CEN box for centromeres, while at anaphase onset—when the histone mark H2AT120 is dephosphorylated—INCENP and Aurora B switch from centromere to microtubule localization.

  16. Interplanetary magnetic field structure at Saturn inferred from nanodust measurements during the 2013 aurora campaign

    Science.gov (United States)

    Hsu, H.-W.; Kempf, S.; Badman, S. V.; Kurth, W. S.; Postberg, F.; Srama, R.

    2016-01-01

    Interactions between the solar wind and planetary magnetospheres provide important diagnostic information about the magnetospheric dynamics. The lack of monitoring of upstream solar wind conditions at the outer planets, however, restrains the overall scientific output. Here we apply a new method, using Cassini nanodust stream measurements, to derive the interplanetary magnetic field structure during the 2013 Saturn aurora campaign. Due to the complex dynamical interactions with the interplanetary magnetic field, a fraction of fast nanodust particles emerging from the Saturnian system is sent back into the magnetosphere and can be detected by a spacecraft located within. The time-dependent directionality caused by the variable interplanetary magnetic field enable these particles to probe the solar wind structure remotely. Information about the arrival time of solar wind compression regions (coupled with the heliospheric current sheet crossings) as well as the field direction associated with the solar wind sector structure can be inferred. Here we present a tentative identification of the interplanetary magnetic field sector structure based on Cassini nanodust and radio emission measurements during the 2013 Saturn aurora campaign. Our results show that, the interplanetary magnetic field near Saturn during 2013-080 to 176 was consistent with a two-sector structure. The intensifications of aurora and the radio emission on 2013-095, 112 and 140 coincide with the IMF sector boundaries, indicating that the encounter of the compressed solar wind is the main cause of the observed activities.

  17. Presumable European aurorae in the mid AD 770s were halo displays

    CERN Document Server

    Neuhaeuser, Dagmar

    2015-01-01

    The interpretation of the strong 14-C variation around AD 775 as one (or several) solar super-flare(s) by, e.g., Usoskin et al. (2013) is based on alleged aurora sightings in the mid AD 770s in Europe: A "red cross/crucifix" in AD 773/4/6 from the Anglo-Saxon Chronicle, "inflamed shields" in AD 776 (both listed in the aurora catalogue of Link 1962), and "riders on white horses" in AD 773 (newly proposed as aurora in Usoskin et al. 2013), the two latter from the Royal Frankish Annals. We discuss the reports about these three sightings in detail here. We can show that all three were halo displays: The "red cross" or "crucifix" is formed by the horizontal arc and a vertical pillar of light (either with the Sun during sunset or with the moon after sunset); the "inflamed shields" and the "riders on white horses" were both two mock suns, especially the latter narrated in form of a Christian adaptation of the antique dioscuri motive. While the latter event took place early in AD 774 (dated AD 773 in Usoskin et al. 2...

  18. Injúrias mecânicas e seus efeitos em pêssegos 'Aurora-1' Effect of mechanical injuries on 'Aurora-1' peaches

    Directory of Open Access Journals (Sweden)

    Giorgia Fernanda Kasat

    2007-08-01

    Full Text Available O objetivo deste trabalho foi avaliar os efeitos das injúrias mecânicas por corte, compressão e impacto na qualidade pós-colheita de pêssegos 'Aurora-1'. Na injúria por impacto, os pêssegos foram deixados cair duas vezes de uma altura de 1,20 m. Por compressão, os frutos foram colocados sob um bloco exercendo um peso constante de 3 kg por 10 minutos. Para a injúria por corte, promoveram-se três incisões longitudinalmente. Manteve-se, ainda, um lote de pêssegos intactos, correspondente ao controle. Após esses tratamentos, os frutos foram armazenados a 10±1,5 °C e 85±2% UR por 8 dias. Avaliaram-se o teor de sólidos solúveis (SS, de acidez titulável (AT e a relação SS/AT, a perda de massa fresca, a aparência, a coloração, a firmeza e o conteúdo de carboidratos solúveis. As injúrias mecânicas promoveram marcas nos pêssegos 'Aurora-1', afetando a aparência dos mesmos, que obtiveram nota ruim a partir do sexto dia de armazenamento. Esses pêssegos, quando submetidos à injúria de impacto, apresentaram maior perda de massa fresca que os do controle, da compressão e do corte. As áreas lesionadas apresentaram-se mais escurecidas, menos amareladas, com menor cromaticidade e menos firmes que as áreas dos frutos não-submetidas às injúrias. Esse efeito deletério também foi verificado quando os frutos eram submetidos à injúria por Impacto, quando comparado com os demais tratamentos. As injúrias mecânicas promoveram um amadurecimento mais rápido dos frutos, verificado pelos maiores valores da relação SS/AT.This work aimed to evaluate the effect of mechanical injuries, impact, compression and cut on the postharvest quality of peaches cv. Aurora-1. Impact injury was obtained dropping fruit, twice, from a height of 1.20 m. Compression injury was performed with the fruit submitted to weight (3 kg for 10 minutes. Cut injury was obtained cutting fruits, three times, in the longitudinal direction. after these treatments

  19. The dayside ultraviolet aurora and convection responses to a southward turning of the interplanetary magnetic field

    Directory of Open Access Journals (Sweden)

    K. A. McWilliams

    Full Text Available We examine the large-scale ultraviolet aurora and convection responses to a series of flux transfer events that immediately followed a sharp and isolated southward turning of the IMF. During the interval of interest, SuperDARN was monitoring the plasma convection in the dayside northern ionosphere, while the VIS Earth Camera and the Far Ul-traviolet Imager (UVI were monitoring the northern hemisphere’s ultraviolet aurora. Reconnection signatures were seen in the SuperDARN HF radar data in the postnoon sector following a sharp southward turning of the IMF. The presence of flux transfer events is supported by measurements of a classic dispersed ion signature in the low-altitude cusp from the DMSP spacecraft. Subsequent to the onset of reconnection, the postnoon convection and ultraviolet aurora expanded in concert, reaching 18 MLT in half an hour. The auroral oval was found to move equatorward at the convection speed in the 16–18 MLT sector, implying that it was related directly to an adiaroic magnetospheric boundary. In the present study, we have estimated the field-aligned current response to magnetic reconnection in terms of the vorticity of the ionospheric plasma convection velocity. The convection velocities were obtained using two methods: (a direct reconstruction of the full vector velocities from bistatic measurements of the convection by the SuperDARN HF radars in a relatively small region of the auroral zone, and (b from global-scale spherical harmonic fits to the SuperDARN velocities deduced from the map potential model. Regions of high vorticity, which were predicted to be an estimate of a component of the total field-aligned current, agree extremely well with the images of the dayside UV aurora, indicating that, in this case, the plasma vorticity is an excellent estimator of the morphology of dayside field-aligned currents (FACs. The morphology of the aurora and ionospheric electric field in the postnoon sector supports the

  20. Auroras and Space Weather Celebrating the International Heliophysics Year in Classroom

    Science.gov (United States)

    Craig, N.; Peticolas, L. M.; Angelopoulos, V.; Thompson, B.

    2007-05-01

    2007 Celebrates the International Heliophysics year and its outreach has a primary objective, to "demonstrate the beauty, relevance and significance of Space and Earth Science to the world." NASA's first five-satellite mission, THEMIS (Time History of Events and Macroscale Interactions during Substorms), was launched on February 17, 2007 and is to investigate a key mystery surrounding the dynamics of the auroras- when, where, and how are they triggered? When the five probes align perfectly over the North American continent- every four days - and with 20 ground stations in Northern Canada and Alaska with automated, all-sky cameras will document the auroras from Earth. To monitor the large-scale local effects of the currents in space, THEMIS Education and Outreach program has installed 10 ground magnetometers, instruments that measure Earth's magnetic field, in competitively selected rural schools around the country and receive data. The THEMIS Education and Outreach Program shares the IHY objective by bringing in this live local space weather data in the classrooms and engaging the teachers and students on authentic research in the classroom. The data are displayed on the school computer monitors as well as on the THEMIS E/PO website providing the local data to the science mission as well as schools. Teachers use the data to teach about the aurora not only in math and science, but also in Earth science, history and art. These students and their teachers are our ambassadors to rural America and share the excitement of learning and teaching with their regional teachers. We will share how authentic space science data related to Earth's magnetic field and auroras can be understood, researched, predicted and shared via the internet to any school around the globe that wished to be part of tracking solar storms. Complimenting IHY, World Space Week will take place from October 4-10th and this year. World Space week is "an international celebration of science and technology

  1. Aquatic baseline report for the Athabasca, Steepbank and Muskeg Rivers in the vicinity of the Steepbank and Aurora Mines

    International Nuclear Information System (INIS)

    Both Suncor Inc., and Syncrude Canada Ltd. plan to expand their operations in the Athabasca oil sands deposit: Suncor in the vicinity of the Steepbank and Athabasca Rivers (Steepbank Mine) and Syncrude in the Muskeg River watershed (Aurora Mine). An aquatic study was conducted in which the current conditions were described with respect to surface water, benthic invertebrates, fish habitat, fish communities and fish health. The study also provided a baseline for future comparisons. River water within the study area was characterized by pHs ranging from 7 to 8, low to moderate dissolved salt concentrations and moderate levels of nutrients. Dissolved organic carbon concentration was high. The major findings in this study were: (1) naturally-occurring hydrocarbons were found in river sediments, but no changes in surface water chemistry were associated with Athabasca oil sands deposits or existing oil sands facilities, (2) benthic invertebrate communities were thriving and showed no indication of negative effects resulting from exposure to naturally-occurring hydrocarbon deposits or existing oil sands developments, (3) fish habitat in the Athabasca River was poor because of the turbid backwaters associated with islands and sandbars, and dynamically shifting sand bottom, (4) high quality habitat was found to exist in the Steepbank and Muskeg Rivers and in some tributaries to these rivers, (5) there were diverse fish communities in the Athabasca, Steepbank and Muskeg River basins, and (6) there was evidence of exposure of fish to naturally-occurring hydrocarbons, however, general indicators suggested that the fish populations were healthy. 112 refs., 100 tabs., 118 figs

  2. Stereoscopic determination of all-sky altitude map of aurora using two ground-based Nikon DSLR cameras

    Science.gov (United States)

    Kataoka, R.; Miyoshi, Y.; Shigematsu, K.; Hampton, D.; Mori, Y.; Kubo, T.; Yamashita, A.; Tanaka, M.; Takahei, T.; Nakai, T.; Miyahara, H.; Shiokawa, K.

    2013-09-01

    A new stereoscopic measurement technique is developed to obtain an all-sky altitude map of aurora using two ground-based digital single-lens reflex (DSLR) cameras. Two identical full-color all-sky cameras were set with an 8 km separation across the Chatanika area in Alaska (Poker Flat Research Range and Aurora Borealis Lodge) to find localized emission height with the maximum correlation of the apparent patterns in the localized pixels applying a method of the geographical coordinate transform. It is found that a typical ray structure of discrete aurora shows the broad altitude distribution above 100 km, while a typical patchy structure of pulsating aurora shows the narrow altitude distribution of less than 100 km. Because of its portability and low cost of the DSLR camera systems, the new technique may open a unique opportunity not only for scientists but also for night-sky photographers to complementarily attend the aurora science to potentially form a dense observation network.

  3. Selected personal highlights from experimental space studies of the aurora (Hannes Alfvén Medal Lecture)

    Science.gov (United States)

    Marklund, Göran

    2013-04-01

    Aurora is a most spectacular and frequently occurring scenery in the winter polar sky, occurring on Earth and many other planets. To further our understanding of the physics of the aurora, numerous sounding rocket and satellite projects have been carried out since the 1960's. Results are presented for a small selection of these where the author and his research team at KTH were strongly engaged in the research, namely a series of rocket experiments and small satellite missions, and the European Space Agency Cluster multi-satellite mission. The electric field plays a fundamental role in the physics of the magnetosphere and of the aurora, such as for the acceleration of electrons and ions producing bright aurora and outflow of energetic plasma. The results include: An arc classification scheme based on the electric field variation across arcs; A method to derive global distributions of electrodynamical parameters for a given auroral oval distribution; The discovery of intense diverging electric fields and of their characteristics in the auroral downward current region; Using Cluster data to reveal how such diverging electric fields evolve in time and are closely tied to the formation of ionospheric density cavities; Reconstruction of an experimentally verified acceleration potential pattern of the aurora, being stable on a 5 min time scale. Finally, acceleration signatures and electrodynamics of large-scale auroral forms, such as spirals, surges, and polar boundary intensifications are discussed based on recent Cluster and DMSP satellite conjunctions.

  4. The real-time state of the aurora -- a research to operations need with a citizen science solution?

    Science.gov (United States)

    Heavner, M.; MacDonald, E.; Case, N.; McCloat, S.

    2015-12-01

    A prototype citizen science application called Aurorasaurus has been developed and launched in 2014. The goal of this platform is crowdsourcing observations of the aurora in real-time in order to assess global visibility of the aurora for the public. Users can submit observations, verify relevant social media observations, learn about the aurora, and receive location-based alerts based on verified reports, all in near real-time. The size and distribution of the citizen scientist community around the world has tremendous potential both for documenting the visible manifestations of global space weather impacts as well as providing quality control on the reported sightings. Information with high spatial and temporal resolution of the largest, most dynamic and mysterious space weather events is made possible by this solution, and this data can be integrated with other ground and space based measures of auroral activity. We will present initial results during the large geomagnetic events of 2015 and comparison to other measures of auroral activity. Our findings indicate the prototype application can be a valuable tool for real-time aurora knowledge and should be included in discussions of real-time aurora nowcasting needs. We will discuss those needs and assess the feasibility of available systems for meeting them.

  5. Records of sunspot and aurora during CE 960-1279 in the Chinese chronicle of the Song dynasty

    CERN Document Server

    Hayakawa, Hisashi; Kawamura, Akito D; Isobe, Hiroaki

    2015-01-01

    Records of sunspots and aurora observations in pre-telescopic historical documents can provide useful information about solar activity in the past. This is also true for extreme space weather events, as they may have been recorded as large sunspots observed by the naked eye or as low-latitude auroras. In this paper, we present the results of a comprehensive survey of records of sunspots and auroras in the Songshi, a Chinese formal chronicle spanning the tenth to the thirteenth century. This chronicle contains a record of continuous observations with well-formatted reports conducted as a policy of the government. A brief comparison of the frequency of observations of sunspots and auroras and the observations of radioisotopes as an indicator of the solar activity during corresponding periods is provided. This paper is the first step of our project in which we survey and compile the records of sunspots and aurora in historical documents from various locations and languages, ultimately providing it to the science...

  6. R. B. Cunninghame Graham’s “Aurora La Cujiñi” (1898 : An Exploration / Aurora La Cujiñi” (1898 de R. B. Cunninghame Graham - Una indagación

    Directory of Open Access Journals (Sweden)

    John C. Mc Intyre

    2011-06-01

    Full Text Available Abstract: In Aurora La Cujiñi-A realistic sketch in Seville, published by the Scottish writer R. B. Cunninghame Graham in 1898, the frontispiece showed the sepia image of a female flamenco dancer. What might ‘La Cujiñi’ mean? Charles Davillier and Gustave Doré in 1862-63 note the existence of a Sevillan dancer with this name. In 2011 the present writer was gifted an old lithograph, in colour, published in Seville ‘c. 1850’ and entitled ‘Aurora La Cujiñí’ - with ñ and í. The two images are supplied. ‘Aurora La Cujiñi’ really existed. Graham’s sketch has five phases: Seville; the bullfight; the crowd’s return to town; a low-quality flamenco show; and the highly stirring performance by an initially anonymous female dancer - the dead Aurora brought back to life. Graham emphasises the Seville blend of blood and sensuality in a realist style also capable of mockery and criticism. Graham’s writing includes a good variety of well-controlled Spanish vocabulary, his empathy with horses and a deep nostalgia for times past. W. H. Hudson, writer and friend of Graham, in 1894 recommended that Graham should read the Argentine sketches published by Alfred Ébélot in 1890. In Aurora La Cujiñi Graham in 1898 is beginning to show mastery of the literary sketch. Question: Might Lorca have read Aurora La Cujiñi before drafting “Teoría y juego del duende”? Resumen: En Aurora La Cujiñi-A realistic sketch in Seville (1898 del escritor escocés R. B. Cunninghame Graham, el frontispicio llevaba la imagen en sepia de una bailadora de flamenco. ¿Qué podría significar ‘La Cujiñi’? Charles Davillier y Gustave Doré en 1862-1863 apuntan la existencia de una bailaora sevillana con este nombre. En 2011 al que esto escribe le regalaron una litografía antigua, en color, publicada en Sevilla ‘hacia 1850’ e intitulada ‘Aurora la Cujiñí’ - con ñ y con í. Se incluyen las dos imágenes. ‘Aurora La Cujiñi’ realmente

  7. Conservação de pêssego 'Aurora-1' armazenados sob refrigeração Keeping quality of peaches 'Aurora-1' stored under refrigeration

    OpenAIRE

    Luis Carlos Cunha Junior; Maria Fernanda Berlingieri Durigan; Ben-Hur Mattiuz

    2010-01-01

    Avaliou-se o comportamento pós-colheita de pêssegos da cv. Aurora-1 armazenados sob refrigeração. Os frutos foram colhidos em dois estádios de maturação, verde maduro (de vez) e maduro. Os lotes foram armazenados em três temperaturas (2°C; 6°C e 12°C), por 35 dias, e avaliados a cada sete dias: quanto à coloração da casca, perda acumulada de massa fresca (PMF), firmeza (FIR), aparência, teores de acidez titulável (AT), sólidos solúveis (SS), açúcares solúveis (AS) e redutores (AR), pectina so...

  8. Conservação de pêssego 'Aurora-1' armazenados sob refrigeração Keeping quality of peaches 'Aurora-1' stored under refrigeration

    Directory of Open Access Journals (Sweden)

    Luis Carlos Cunha Junior

    2010-06-01

    Full Text Available Avaliou-se o comportamento pós-colheita de pêssegos da cv. Aurora-1 armazenados sob refrigeração. Os frutos foram colhidos em dois estádios de maturação, verde maduro (de vez e maduro. Os lotes foram armazenados em três temperaturas (2°C; 6°C e 12°C, por 35 dias, e avaliados a cada sete dias: quanto à coloração da casca, perda acumulada de massa fresca (PMF, firmeza (FIR, aparência, teores de acidez titulável (AT, sólidos solúveis (SS, açúcares solúveis (AS e redutores (AR, pectina solúvel (PS e total (PT, além da porcentagem de solubilização de pectinas (SOL. A menor temperatura de armazenamento elevou o tempo de prateleira dos pêssegos, e os frutos "de vez" apresentaram melhor aparência. A PMF demonstrou um gradiente em função do aumento da temperatura, e os frutos "de vez" apresentaram menor perda ao final do armazenamento sob todas as temperaturas, quando comparados aos maduros. A coloração da casca dos frutos "de vez", a 2°C, teve pouca alteração, conferindo-lhes mudança de coloração de verde-amarelada para amarelo-clara; enquanto nas temperaturas de 6°C e 12°C esse gradiente foi mais intenso. O mesmo efeito foi verificado nos pêssegos maduros. A FIR sofreu efeito da temperatura, pois temperaturas menores sofreram redução mais lenta e AT dos pêssegos maduros foi superior aos "de vez". Não houve influência dos tratamentos nos teores de SS, AS e AR. Os pêssegos 'Aurora-1' não demonstraram sensibilidade ao frio, e os "de vez", armazenados a 2°C, tiveram vida útil de 35 dias.This work aimed to evaluate the postharvest of peaches cv. Aurora-1 stored under refrigeration. The fruit were harvested in two stages ("mature green" and ripe. The lots were stored at three temperatures (2°C, 6°C, and 12°C, for 35 days and evaluated every seven days for skin color, loss of fresh mass (PMF, firmness (FIR, appearance, titratable acidity (TA, soluble solids (SS, soluble (AS and reducing (AR sugars, soluble

  9. Ultraviolet aurora on outer planets: morphology and remote sensing of electron precipitation

    Science.gov (United States)

    Gerard, Jean-Claude; Bisikalo, Dmitry; Shematovich, Valery; Soret, Lauriane

    2016-07-01

    The aurora is the result of the interaction between energetic particles and the upper atmosphere of a planet. Generally, energetic particles from the magnetosphere penetrate the atmosphere, partly deposit their energy and are partly reflected. Their collisional interactions with the atmospheric atoms and molecules heat the atmosphere and produce auroral emissions. Consequently, the aurora then bears the signature of both the acceleration mechanism and the atmospheric structure and composition. Jupiter's UV auroral H2 and H emissions are generally divided into several components. The main auroral emission at Jupiter is associated with the giant current loop connecting the region of co-rotation breakdown in the middle magnetosphere with the ionosphere. The polar emissions observed inside the main emission are very variable over short timescales. The observed diffuse emission equatorward of the main emission is most likely related to precipitation resulting from wave-particle interactions. Finally, the satellite magnetic footprints are created by accelerated electrons resulting from the interaction between the Galilean moons and the plasma in the Jovian magnetosphere. Saturn's magnetosphere and its aurorae appear to be both solar wind driven as the terrestrial magnetosphere and rotationally dominated, similarly to Jupiter. In addition to the main auroral ring, transient features have been recently identified. Uranus displays aurorae quite different from the other two with faint small-size structures appearing following solar storm activity. These different processes are probably associated with different energy spectra of the precipitated electrons. We present an overview of recent results concerning the relation between morphology, variability and remote sensing of the auroral electron energy in the different components. We show that mapping the UV color ratio is a powerful tool to globally characterize the electron precipitation and the flux-energy relation

  10. Aurora kinase B is important for antiestrogen resistant cell growth and a potential biomarker for tamoxifen resistant breast cancer

    DEFF Research Database (Denmark)

    Larsen, Sarah L; Yde, Christina W; Laenkholm, Anne-Vibeke;

    2015-01-01

    endocrine resistance, immunohistochemistry was performed on archival primary tumor tissue from breast cancer patients who have received adjuvant endocrine treatment with tamoxifen. RESULTS: The selective Aurora kinase B inhibitor barasertib was identified to preferentially inhibit growth of fulvestrant...... and PARP cleavage in the fulvestrant resistant cells. Barasertib also exerted preferential growth inhibition of tamoxifen resistant T47D cell lines. Finally, high percentage of Aurora kinase B positive tumor cells was significantly associated with reduced disease-free and overall survival in 261 ER......-positive breast cancer patients, who have received tamoxifen as first-line adjuvant endocrine treatment. CONCLUSIONS: Our results indicate that Aurora kinase B is a driving factor for growth of antiestrogen resistant T47D breast cancer cell lines, and a biomarker for reduced benefit of tamoxifen treatment. Thus...

  11. Volumetric characterization of the Aurora magnetic tracker system for image-guided transorbital endoscopic procedures

    International Nuclear Information System (INIS)

    In some medical procedures, it is difficult or impossible to maintain a line of sight for a guidance system. For such applications, people have begun to use electromagnetic trackers. Before a localizer can be effectively used for an image-guided procedure, a characterization of the localizer is required. The purpose of this work is to perform a volumetric characterization of the fiducial localization error (FLE) in the working volume of the Aurora magnetic tracker by sampling the magnetic field using a tomographic grid. Since the Aurora magnetic tracker will be used for image-guided transorbital procedures we chose a working volume that was close to the average size of the human head. A Plexiglass grid phantom was constructed and used for the characterization of the Aurora magnetic tracker. A volumetric map of the magnetic space was performed by moving the flat Plexiglass phantom up in increments of 38.4 mm from 9.6 mm to 201.6 mm. The relative spatial and the random FLE were then calculated. Since the target of our endoscopic guidance is the orbital space behind the optic nerve, the maximum distance between the field generator and the sensor was calculated depending on the placement of the field generator from the skull. For the different field generator placements we found the average random FLE to be less than 0.06 mm for the 6D probe and 0.2 mm for the 5D probe. We also observed an average relative spatial FLE of less than 0.7 mm for the 6D probe and 1.3 mm for the 5D probe. We observed that the error increased as the distance between the field generator and the sensor increased. We also observed a minimum error occurring between 48 mm and 86 mm from the base of the tracker

  12. Large-scale KrF systems for inertial confinement fusion based on Aurora experience

    International Nuclear Information System (INIS)

    The ultimate amplifier in the Aurora system was originally conceived as a stackable module suitable for construction of much larger systems. The name habitually used to describe it, large aperture module (LAM), is derived from this concept. The principal initial objective of what is now named Aurora was to test the viability of this module and obtain working experience with it. Although it is no longer clear that this is the largest feasible amplifier size, or even that a large amplifier size is advantageous, it is still true that the working experience gained in Aurora creates a special place for this particular module size. It is valuable to examine the limitations and difficulties of stacking LAMs. The key concept is aperture combination. This reduces the complexity of the decoder by combining the outputs of several amplifiers in each time channel so that they can be directed to a common large delay mirror. For this to be effective, the relevant group of amplifiers must be placed close together. A layout containing 128 parallel LAMs in its ultimate gain stage is displayed and explained in detail. An improved version of the LAM might be capable of producing 25 kJ at its output window. This array would then produce 3.2 MJ, of which perhaps 2.8 MJ would reach the target. This layout contains eight separate decoders, each handling the output of a group of sixteen LAMs, arranged symmetrically around a central target chamber. This giant system divides naturally into subsystems which could be built to meet interim objectives

  13. A magnetohydrodynamic simulation study of Kronian field-aligned currents and auroras

    Science.gov (United States)

    Fukazawa, Keiichiro; Ogino, Tatsuki; Walker, Raymond J.

    2012-02-01

    Magnetohydrodynamic simulations of the interaction of Saturn's magnetosphere with the solar wind indicate that Kelvin-Helmholtz (K-H) waves can form on the dayside magnetopause when the interplanetary magnetic field (IMF) is northward. Dayside magnetic reconnection occurs at Saturn for northward IMF, and the combination of K-H waves and reconnection caused enhanced vorticity in Saturn's magnetosphere. We have used a very high resolution version (Δx = 0.1 RS) of our simulation code to study the consequences of the vortices and reconnection for the generation of field-aligned currents (FACs) and auroras in Saturn's ionosphere. We found three bands of alternating FACs toward and away from the dawn side of the ionosphere and two sets on the dusk side. The K-H waves generated a series of toward and away currents along the dayside magnetopause. In the ionosphere they appear as a series of spots of up and down currents. The K-H field-aligned currents are adjacent to nearly continuous currents located from 16:00 LT, to around past midnight, and to about 07:00 LT. The largest currents densities (j∥ > 5 × 10-8 A m-2) are found at the highest latitudes. They map to the magnetopause and to the near-Saturn tail region. We used the away current density and the Knight relationship to estimate the energy flux related to discrete auroras and obtained ˜1 mW m-2 in the region with the strongest currents. This gives approximately 7 GW for the auroral UV emitted power. We found a region of enhanced thermal energy flux in the region where cusp auroras are observed.

  14. Stratospheric temperature and composition of Jupiter's polar aurora from IRTF-TEXES

    Science.gov (United States)

    Sinclair, J.; Orton, G. S.; Greathouse, T. K.; Fletcher, L. N.; Irwin, P. G. J.

    2015-10-01

    We perform an analysis of TEXES (Texas Echelon Cross Echelle Spectrograph, 5- to 25- μm,[1]) spectra of Jupiter's high latitudes observed in December 2014 in order to study the jovian polar aurora. The high resolving power (R˜85000) of TEXES allows a large altitude range (10 mbar to 0.01 mbar) in Jupiter's stratosphere to be sounded. Retrievals of temperature and stratospheric composition of these measurements therefore: 1) allow the vertical deposition of auroral energy to be determined and 2) quantify how the auro-ral processes modify the thermal structure and composition of the jovian stratosphere.

  15. Saturn’s UV aurora: the (high latitude) point of view of Cassini

    OpenAIRE

    Grodent, Denis; Bonfond, Bertrand; Gustin, Jacques; Radioti, Aikaterini; Gérard, Jean-Claude; Pryor, Wayne

    2013-01-01

    The high latitude vantage point of Cassini and its short distance to Saturn give rise to a unique opportunity for obtaining exceptional spectral images of the aurorae, along with in situ observations of the associated particles and magnetic field. Cassini’s T83 flyby of Titan significantly changed the inclination of the spacecraft’s orbit and marked the beginning of the XXM inclined phase 1 which will last until March 16, 2015. We will give an overview of the auroral emissions observed so ...

  16. BimEL is phosphorylated at mitosis by Aurora A and targeted for degradation by βTrCP1

    OpenAIRE

    Moustafa-Kamal, M; Gamache, I; Lu, Y.; Li, S; Teodoro, J G

    2013-01-01

    Bcl-2-interacting mediator of cell death (Bim) is a pro-apoptotic B-cell lymphoma 2 family member implicated in numerous apoptotic stimuli. In particular, Bim is required for cell death mediated by antimitotic agents, however, mitotic regulation of Bim remains poorly understood. Here, we show that the major splice variant of Bim, BimEL, is regulated during mitosis by the Aurora A kinase and protein phosphatase 2A (PP2A). We observed that BimEL is phosphorylated by Aurora A early in mitosis an...

  17. Occurrence of multipolar mitoses and association with Aurora-A/-B kinases and p53 mutations in aneuploid esophageal carcinoma cells

    Directory of Open Access Journals (Sweden)

    Münch Claudia

    2011-04-01

    Full Text Available Abstract Background Aurora kinases and loss of p53 function are implicated in the carcinogenesis of aneuploid esophageal cancers. Their association with occurrence of multipolar mitoses in the two main histotypes of aneuploid esophageal squamous cell carcinoma (ESCC and Barrett's adenocarcinoma (BAC remains unclear. Here, we investigated the occurrence of multipolar mitoses, Aurora-A/-B gene copy numbers and expression/activation as well as p53 alterations in aneuploid ESCC and BAC cancer cell lines. Results A control esophageal epithelial cell line (EPC-hTERT had normal Aurora-A and -B gene copy numbers and expression, was p53 wild type and displayed bipolar mitoses. In contrast, both ESCC (OE21, Kyse-410 and BAC (OE33, OE19 cell lines were aneuploid and displayed elevated gene copy numbers of Aurora-A (chromosome 20 polysomy: OE21, OE33, OE19; gene amplification: Kyse-410 and Aurora-B (chromosome 17 polysomy: OE21, Kyse-410. Aurora-B gene copy numbers were not elevated in OE19 and OE33 cells despite chromosome 17 polysomy. Aurora-A expression and activity (Aurora-A/phosphoT288 was not directly linked to gene copy numbers and was highest in Kyse-410 and OE33 cells. Aurora-B expression and activity (Aurora-B/phosphoT232 was higher in OE21 and Kyse-410 than in OE33 and OE19 cells. The mitotic index was highest in OE21, followed by OE33 > OE19 > Kyse-410 and EPC-hTERT cells. Multipolar mitoses occurred with high frequency in OE33 (13.8 ± 4.2%, followed by OE21 (7.7 ± 5.0% and Kyse-410 (6.3 ± 2.0% cells. Single multipolar mitoses occurred in OE19 (1.0 ± 1.0% cells. Distinct p53 mutations and p53 protein expression patterns were found in all esophageal cancer cell lines, but complete functional p53 inactivation occurred in OE21 and OE33 only. Conclusions High Aurora-A expression alone is not associated with overt multipolar mitoses in aneuploid ESCC and BAC cancer cells, as specifically shown here for OE21 and OE33 cells, respectively

  18. Solar wind-Magnetosphere-Ionosphere Coupling and Aurora at Jupiter and Saturn

    Science.gov (United States)

    Bunce, E. J.; Cowley, S. W. H.

    2015-10-01

    Solar wind-magnetosphere-ionosphere coupling is accomplished through the existence of largescale field-aligned currents which are generated in a source region and end in a sink region, and which transfer momentum (and energy) between the regions. Therefore, to move beyond a theoretical picture of how this works at Jupiter and Saturn we require in-situ measurements of these regions primarily in the form of magnetic field measurements, but importantly combined with in-situ plasma, plasma wave data, and remote auroral observations. Since the arrival of Cassini at Saturn in 2004 we have had many opportunities to sample the high-latitude magnetosphere and aurora and have learned a great deal about how this giant magnetosphere works. We also await the "proximal" orbit phase of Cassini where we will obtain information on the high-latitude magnetosphere very close to Saturn. In the case of Jupiter, we eagerly anticipate the first high-latitude observations from the Juno mission, due to arrive in the Jupiter system in 2016. The simultaneous observations from Cassini at Saturn in the final phase of the mission until 2017, and Juno at Jupiter during 2016/17, will be a first in planetary science, and we expect to learn a great deal about both planetary magnetospheres individually and by comparison. Here then, we will give an overview of what we have learned so far from Cassini at Saturn, and how it might apply to Juno at Jupiter. A principal "source" of the field-aligned currents is the planetary neutral atmosphere, that at Saturn imposes both sub-corotation (and is axi-symmetric to a first approximation), as well as an m=1 rotating twin-vortex perturbation of comparable magnitude. The Cassini data have revealed that there are two separate systems in the Northern and Southern hemispheres rotating with slowly-changing separate periods. These have been systematically studied, principally in the pre-equinox (2008) Cassini data on the nightside. The sub-corotation system of field

  19. Integration of the Aurora KrF ICF laser system at Los Alamos

    International Nuclear Information System (INIS)

    The Aurora laser system, under construction at the Los Alamos National Laboratory for the past few years, is now being integrated into a working system for examining the applicability of high-power KrF lasers to inertial confinement fusion (ICF). The design principles of the system have been described in detail in earlier publications and conferences. Multikilojoule 248-nm 5-ns duration laser pulses, which have been derived from angular-multiplexed electron-beam-driven KrF amplifiers, are to be delivered to ICF targets when the system is fully integrated. The authors describe the progress of the Aurora system toward the goal of delivering energy (MkJ/48 pulses stacked into one 5-ns pulse/200-μm spot) to ICF targets. Integrated performance to date of the front end optical multiplexer/demultiplexer e-beam-driven amplifiers and alignment hardware are discussed in particular. They have concentrated on the demonstration of system integration at a modest (--100-J) level of energy on-target (without the final amplifier stage). They discuss the amplifier gain measurements, the extraction of energy from a chain of three e-beam-driven machines, and progress toward the delivery of on-target energy

  20. Recent progress on the Los Alamos Aurora ICF [inertial confinement fusion] laser system

    International Nuclear Information System (INIS)

    Aurora is the Los Alamos short-pulse, high-power, krypton-fluoride laser system. It serves as an end-to-end technology demonstration prototype for large-scale ultraviolet laser systems for short wavelength inertial confinement fusion (ICF) investigations. The system is designed to employ optical angular multiplexing and serial amplification by electron-beam-driven KrF laser amplifiers to deliver stacked, 248-nm, 5-ns duration multikilojoule laser pulses to ICF-relevant targets. This paper presents a summary of the Aurora system and a discussion of the progress achieved in the construction and integration of the laser system. We concentrate on the main features of the following major system components: front-end lasers, amplifier train, multiplexer, optical relay train, demultiplexer, and the associated optical alignment system. During the past year, two major construction and integration tasks have been accomplished. The first task is the demonstration of 96-beam multiplexing and amplified energy extraction, as evidenced by the integrated operation of the front end, the multiplexer (12-fold and 8-fold encoders), the optical relay train, and three electron-beam-driven amplifiers. The second task is the assembly and installation of the demultiplexer optical hardware, which consists of over 300 optical components ranging in size from several centimeters square to over a meter square. 13 refs., 13 figs

  1. Improved performance of the Aurora KrF/ICF laser system

    International Nuclear Information System (INIS)

    This paper reports on Aurora the Los Alamos National Laboratory short pulse high power krypton-fluoride laser system. It serves as an end-to-end technology demonstration prototype for large scale UV laser systems for short wavelength inertial confinement fusion (ICF) research. The system employs optical angular multiplexing and serial amplification by electron-beam driven KrF laser amplifiers. The 1-5-ns pulse of the Aurora front end is split into ninety-six beams which are angularly and temporally multiplexed to produce a 480-ns pulse train for amplification by four KrF laser amplifiers. The largest amplifier, the large aperture module (LAM), has a 1-m square aperture and a gain length of 2 m. In the present system configuration half (forty-eight) of the amplified pulses are demultiplexed using different optical path lengths and delivered simultaneously to target. The system has not been optimized, and several near term improvements are expected to result in significant increases in both delivered energy and target irradiance. Removing the twelve calorimeters from the lens plate and allowing forty-eight beams to go to target will increase delivered energy by 33%. Relatively minor modifications to the front end should result in a 30% increase in system output energy. Replacement of damaged optics will increase transmission into the preamplifier by at least 25%. New optics and reduction of retro-pulses will allow the preamplifier stage gain to be increased by 50%

  2. New auroras on the roles of the Chromosomal Passenger Complex in cytokinesis: implications for cancer therapies

    Directory of Open Access Journals (Sweden)

    Pier Paolo eD'Avino

    2015-10-01

    Full Text Available The Chromosomal Passenger Complex (CPC, composed of a kinase component, Aurora B, the scaffolding subunit Inner Centromeric Protein (INCENP, Borealin, and Survivin, is a key regulator of cell division. It controls multiple events, from chromosome condensation in prophase to the final separation or abscission of the two daughter cells. The essential functions of the CPC during metaphase, however, have always hindered an accurate study of its role during cytokinesis. The recent development of small molecule inhibitors against Aurora B and the use of elegant technologies such as chemical genetics have offered new approaches to study the functions of the CPC at the end of cell division. Here we review the recent findings about the roles of the CPC in controlling the assembly of the cleavage furrow, central spindle and midbody. We will also discuss the crucial function of this complex in controlling abscission timing in order to prevent abscission when lagging chromatin is present at the cleavage site, thereby avoiding the formation of genetically abnormal daughter cells. Finally, we offer our perspective on how to exploit the potential therapeutic applications of inhibiting CPC activity during cytokinesis in cancer cells.

  3. Imaging-based observations of low-latitude auroras during 2001-2004 at Nayoro, Japan

    Science.gov (United States)

    Suzuki, Hidehiko; Chino, Haruka; Sano, Yasuo; Kadokura, Akira; Ejiri, Mitsumu K.; Taguchi, Makoto

    2015-07-01

    Color images of six low-latitude auroral events observed using color digital cameras at Nayoro (142.5° E, 44.4° N), Hokkaido, Japan, from 2001 to 2004, were analyzed to determine the events' locations and times of occurrence. Geographical azimuthal and elevation angles of the images' pixels were determined precisely by using the positions of the stars captured in the images. Horizontal regions covered by these auroral events were directly indicated by mapping the color images onto geographical maps and assuming that the emission layer's altitude is the lowest or highest value of a visible-level red aurora, as determined by the OI 630.0nm emission. The estimated geomagnetic latitudes and L values of these low-latitude auroral events were in the 39-50° range and below L reported previously based on high-sensitivity optical observations at other sites on Hokkaido (Rikubetsu and Moshiri). Although the previous study is lacking information about the maximal brightness level of the red auroral events, the present investigation suggests that these four low-latitude auroral events reached the visible level. In addition, two new events were reported in this study. The present work provides essential information such as the morphology and appearance of visible auroras, which are extremely rare in mid- or low-latitude regions.

  4. Precipitation of relativistic electrons of the Van Allen belts into the proton aurora

    Energy Technology Data Exchange (ETDEWEB)

    Jordanova, Vania K [Los Alamos National Laboratory; Miyoshi, Y [NAGOYA UNIV; Sakaguchi, K [NAGOYA UNIV; Shiokawa, K [NAGOYA UNIV; Evans, D S [SEC/NOAA; Albert, Jay [AFRL; Connors, M [UNIV OF ATHABASCA

    2008-01-01

    The Van Allen electron belts consist of two regions encircling the earth in which relativistic electrons are trapped in the earth's magnetic field. Populations of relativistic electrons in the Van Allen belts vary greatly with geomagnetic disturbance and they are a major source of damage to space vehicles. In order to know when and by how much these populations of relativistic electrons increase, it is important to elucidate not only the cause of acceleration of relativistic electrons but also the cause of their loss from the Van Allen belts. Here we show the first evidence that left-hand polarized electromagnetic ion cyclotron (EMIC) plasma waves can cause the loss of relativistic electrons into the atmosphere, on the basis of results of an excellent set of ground and satellite observations showing coincident precipitation of ions with energies of tens of keV and of relativistic electrons into an isolated proton aurora. The proton aurora was produced by precipitation of ions with energies of tens of keV due to EMIC waves near the plasma pause, which is a manifestation of wave-particle interactions. These observations clarify that ions with energies of tens of keV affect the evolution of relativistic electrons in the Van Allen belts via parasitic resonance with EMIC waves, an effect that was first theoretically predicted in the early 1970's.

  5. Independencia y su expresión léxica en la Aurora de Chile Independence and its lexical expression in the Aurora de Chile

    Directory of Open Access Journals (Sweden)

    Mariano Franco Figueroa

    2010-01-01

    Full Text Available Tomando como base documental el semanario Aurora de Chile, se realiza un análisis lingüístico que describe las caracterizaciones léxicas acomodadas a los nuevos contextos sociolingüísticos en esta época histórica de la independencia colonial y los fenómenos gramaticales que permiten observar rasgos diferenciadores en la lengua que se asienta en esta sociedad chilena. Por una parte, resulta interesante constatar la variación léxica que este texto periodístico, portavoz de una ideología ilustrada, proporciona para alcanzar un mejor conocimiento del grado de penetración del nuevo léxico político-social, con voces en muchos casos recreadas con las acepciones dominantes en las comunidades insurgentes. Por otra, la descripción de los fenómenos gramaticales y del léxico general de este corpus aporta datos concretos acerca de la preferencia de estas variantes lingüísticas y del grado de estandarización que van adquiriendo, como usos emergentes de la lengua española en Chile, bien como asentamientos de estructuras sintácticas y de léxico tradicionales o bien como mecanismos innovadores en la gramática y en el vocabulario diferencial americano.Based on the weekly newspaper Aurora de Chile, a linguistic analysis is here introduced including both the description of lexical characterizations as they adapted to the new sociolinguistic contexts in the historical period of the colonial emancipation and the grammatical phenomena that allow for the observation of differentiating features of the language being established in the Chilean society of the time. On the one hand, it is of interest to observe the lexical variation displayed in this journalistic text, which represents an illustrated ideology, in order to better understand the degree of penetration of the new political and social vocabulary, with voices in many cases recreated with uses dominating the insurgent communities. On the other hand, the description of the grammatical

  6. Facilities & Leadership

    Data.gov (United States)

    Department of Veterans Affairs — The facilities web service provides VA facility information. The VA facilities locator is a feature that is available across the enterprise, on any webpage, for the...

  7. San Huang Decoction downregulates Aurora kinase A to inhibit breast cancer cell growth and enhance chemosenstivity to anti-tumor drugs.

    Science.gov (United States)

    Xu, Yanlei; Chen, Xu; Chen, Xiyan; Bian, Weihe; Yao, Chang; Zhang, Xiaoqing; Zhu, Xiaoshu; Chen, Jiajing; Ye, Xiaozhou

    2016-08-01

    Our study aimed to explore whether San Huang Decoction (SHD) inhibited the development of breast cancer by regulating Aurora A. Human breast cancer cell lines MCF-7 and MDA-MB-231 were cultured and SHD extract was prepared. Cell growth assay and apoptosis analysis were respectively performed to detect the effects of SHD on breast cancer cells. In addition, the effects of SHD on the expression of Aurora A and p53 were determined by RT-PCR and western blot. Besides, we used Aurora A siRNA to knock down Aurora A. We then co-administrated SHD and tamoxifen or epirubicin to detect the effect of SHD on chemosensitivity to tamoxifen or epirubicin. SHD treatment significantly inhibited cell growth in a dose-dependent manner. Moreover, SHD treatment resulted in a marked decrease in Aurora A expression and obvious increase in p53 expression. In addition, knockdown of Aurora A induced cell growth inhibition, which was similar to the effect of SHD treatment. Besides, SHD exerted an additive effect on cell growth inhibition and apoptosis induction when breast cancer cells were co-administration of SHD with tamoxifen or epirubicin. Our study indicates that SHD treatment may inhibit cell growth and enhance chemosenstivity to other anti-tumor drugs in breast cancer via down-regulation of Aurora A. PMID:27461831

  8. High expression of nuclear survivin and Aurora B predicts poor overall survival in patients with head and neck squamous cell cancer

    Energy Technology Data Exchange (ETDEWEB)

    Erpolat, O.P.; Akmansu, M. [Medical School of Gazi Univ., Besevler-Ankara (Turkey). Dept. of Radiation Oncology; Gocun, P.U.; Karakus, E.; Akyol, G. [Medical School of Gazi Univ., Besevler-Ankara (Turkey). Dept. of Pathology

    2012-03-15

    Survivin is one of the apoptosis inhibitor proteins. Together with Aurora B, it also plays a role in regulating several aspects of mitosis. High expression of these markers is correlated with malignant behavior of various cancers and resistance to therapy. Our aim was to evaluate the prognostic role of these markers in head and neck cancers. We evaluated the expression of Aurora B and survivin in tissue specimens of 58 patients with head and neck squamous cell carcinoma using immunohistochemistry. Patients who showed high expression of cytoplasmic and nuclear survivin and Aurora B had significantly shorter overall survival (p = 0.036, p < 0.000, p = 0.032, respectively). In multivariate analysis, high expression of nuclear survivin was the only independent negative prognostic factor (p = 0.024). Moreover, it was found that high co-expression of nuclear survivin and Aurora B had a negative effect on survival in univariate (p < 0.000) and multivariate (p < 0.000) analyses. The negative prognostic values of high expression of Aurora B and high co-expression of nuclear survivin and Aurora B on survival were shown. These findings suggest that co-expression of nuclear survivin and Aurora B can be useful diagnostic markers and therapeutic targets for head and neck squamous cell carcinoma. However, further studies with a larger number of patients in a more homogeneous disease group are needed to confirm the conclusion.

  9. Dithiocarbamate promoted practical synthesis of N-Aryl-2-aminobenzazoles: Synthesis of novel Aurora-A kinase inhibitor

    Indian Academy of Sciences (India)

    Naresh Kumar Katari; M Venkatanarayana; Kummari Srinivas

    2015-03-01

    Various N-aryl-2-aminobenzoxazoles and N-aryl-2-aminobenzothiazoles were synthesized from o-aminophenol and o-aminothiophenol, respectively, mediated by dithiocarbamate in one step. The salient features of this method include mild reaction condition, high yield and large scale synthesis. Application of this methodology has been demonstrated by synthesizing potent Aurora kinase-A inhibitors.

  10. Biochemistry Facility

    Data.gov (United States)

    Federal Laboratory Consortium — The Biochemistry Facility provides expert services and consultation in biochemical enzyme assays and protein purification. The facility currently features 1) Liquid...

  11. Aurora A反义寡核苷酸对肺癌细胞A549的作用和对紫杉醇化疗敏感性的影响%The effect of antisense oligodeoxynucleotides targeting Aurora A kinase on cell proliferation and chemosensitivity to paclitaxel in human lung cancer cell line A549

    Institute of Scientific and Technical Information of China (English)

    Rui Meng; Gang Wu; Jing Cheng; Tao Wang

    2007-01-01

    Objective:Aurora A kinase representing a family of evolutionarily conserved mitotic serine/threonine kinases has been found elevated in human lung adenocarcinoma cell line A549.It is suggested that the overexpression of Aurora A contributes to the carcinogenesis,chromosomal instability (CIN),and de-differentiation of lung cancers.To address its possibility as a therapeutic target for lung cancer,we employed the antisense oligodeoxynucleotide (ASODN) technique to inhibi Aurora A expression and investigate its effects on tumor growth and cell cycle of A549.as well as the chemosensitivilty to paclitaxel.Methods:Aurora A ASODN was synthesized and transfected into A549 cells by lipofectAMINE 2000.Aurora A mRNA and protein expression were examined by reverse transcription-polymerase chain reaction (RT-PCR) and Western blot respectively.Cell cycle distribution was observed by flow cytometer.MTT assay was used to evaluate cell inhibition ratio before and after transfection.Results:The proliferation of the A549 cell swas inhibited by Aurora AASODN dose and time dependently.It was also observed thal the IC50 of A549 cells after 48 hours'treatmenl of ASODN was about 300 nmol/L and under such circumstances,the Aurora A mRNA and protein expression significantly decreased(P<0.05),along with the induction of accumulation of cells in S phase and the G2-M transition.Furlhermore.cell inhibition ratio of the combination of Aurora AASODN and paclitaxel was higher significantly than paclitaxel(P<0.05)or Aurora AASODN alone (P<0.05).Conclusion:Inhibition of Aurora A expression can result in the suppression of cell growth and chemosensilizina activity to paclitaxel in human lung cancer cell line A549.

  12. Substorm aurora and magnetic tail dynamics during interplanetary shock compression: THEMIS observations

    Science.gov (United States)

    Angelopoulos, Vassilis; Zhou, Xiaoyan

    2012-07-01

    Fast and forward interplanetary shocks compress and squeeze the Earth magnetosphere and cause a series of magnetospheric and ionospheric reactions. In addition to the enhancement of chorus, electromagnetic ion cyclotron (EMIC) waves and magnetospheric hiss, the ionospheric convection is enhanced as well. Shock aurora is generated, which is a phenomenon first an auroral brightness onset near local noon right after the shock impingement then followed by a fast anti-sunward auroral propagation along the oval. It has been found that substorm auroral activity can be significantly intensified by the shock compression when the shock upstream magnetic field was in southward in a certain period of time. This paper will present recent results based on the THEMIS spacecraft and ground-based observations. With multiple spacecraft in the magnetotail, the complex dynamics of the compressed tail is identified and analyzed. Correlations between the tail dynamics and substorm auroral variations will be discussed. *On-leave from Jet Propulsion Laboratory

  13. The Morphology of the X-ray Emission above 2 keV from Jupiter's Aurorae

    Science.gov (United States)

    Elsner, R.; Branduardi-Raymont, G.; Galand, M.; Grodent, D.; Gladstone, G. R.; Waite, J. H.; Cravens, T.; Ford, P.

    2007-01-01

    The discovery in XMM-Newton X-ray data of X-ray emission above 2 keY from Jupiter's aurorae has led us to reexamine the Chandra ACIS-S observations taken in Feb 2003. Chandra's superior spatial resolution has revealed that the auroral X-rays with E > 2 keV are emitted from the periphery of the region emitting those with E < 1 keV. We are presently exploring the relationship of this morphology to that of the FUV emission from the main auroral oval and the polar cap. The low energy emission has previously been established as due to charge exchange between energetic precipitating ions of oxygen and either sulfur or carbon. It seems likely to us that the higher energy emission is due to precipitation of energetic electrons, possibly the same population of electrons responsible for the FUV emission. We discuss our analysis and interpretation.

  14. H3S10 phosphorylation-mediated transcriptional regulation by Aurora kinase A.

    Science.gov (United States)

    Kim, Se-Ryeon; Kim, Kee-Beom; Chae, Yun-Cheol; Park, Jin Woo; Seo, Sang-Beom

    2016-01-01

    Histone H3S10 phosphorylation has been known as a cell cycle-specific marker and has a role in transcriptional activation. Various kinases phosphorylate H3S10 in different species, however, the role of the mitotic serine/threonine protein kinase Aurora A (AURKA) is largely unknown. Here we present evidence that AURKA phosphorylates H3S10 and activates target gene transcription. We show that down-regulation of AURKA level during leukemia cell differentiation results in decreased H3S10 phosphorylation level. We further show that AURKA is recruited to target gene promoters and activates transcription via H3S10 phosphorylation. Furthermore, this recruitment can be disrupted by the AURKA inhibitor Alisertib and results in H3K9-me2 recruitment by G9a. PMID:26607113

  15. Plant Aurora kinases play a role in maintenance of primary meristems and control of endoreduplication

    Czech Academy of Sciences Publication Activity Database

    Petrovská, Beáta; Cenklová, Věra; Pochylová, Žaneta; Kourová, Hana; Doskočilová, Anna; Plíhal, Ondřej; Binarová, Lenka; Binarová, Pavla

    2012-01-01

    Roč. 193, č. 3 (2012), s. 590-604. ISSN 0028-646X R&D Projects: GA ČR(CZ) GA204/07/1169; GA ČR GP204/09/P155; GA ČR(CZ) GD204/09/H084; GA MŠk(CZ) LC06034; GA MŠk LC545; GA AV ČR IAA500200719 Grant ostatní: GA MŠk(CZ) ED0007/01/01 Institutional research plan: CEZ:AV0Z50380511; CEZ:AV0Z50200510 Keywords : Arabidopsis thaliana * AtTPX2 (targeting protein for Xklp2) * Aurora kinases Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 6.736, year: 2012

  16. An extensive survey of dayside diffuse aurora based on optical observations at Yellow River Station

    CERN Document Server

    Han, De-Sheng; Liu, Jian-Jun; Qiu, Qi; Keika, K; Hu, Ze-Jun; Liu, Jun-Ming; Hu, Hong-Qiao; Yang, Hui-Gen

    2016-01-01

    By using 7 years optical auroral observations obtained at Yellow River Station (magnetic latitude $76.24\\,^{\\circ}{\\rm C}$N) at Ny-Alesund, Svalbard, we performed the first extensive survey for the dayside diffuse auroras (DDAs) and acquired observational results as follows. (1) The DDAs can be classified into two broad categories, i.e., unstructured and structured DDAs. The unstructured DDAs are mainly distributed in the morning and afternoon, but the structured DDAs predominantly occurred around the magnetic local noon (MLN). (2) The unstructured DDAs observed in morning and afternoon present obviously different properties. The afternoon ones are much stable and seldom show pulsating property. (3) The DDAs are more easily observed under geomagnetically quiet times. (4) The structured DDAsmainly show patchy, stripy, and irregular forms and are often pulsating and drifting. The drifting directions are mostly westward (with speed $\\sim$5km/s), but there are cases showing eastward or poleward drifting. (5) The ...

  17. Observations of a travelling aurorae curvature to the west in the dayside polar cap

    International Nuclear Information System (INIS)

    Results of visual and photometrical observations at the Vostok antarctic station are presented. The data obtained testify to the fact that during strong magnetic disturbanel auroral curvature and auroral crinkle associated with it can penetrate deeply nto the dayside polar cap. These extraordinary auroral were observed at the Vostok station during the world storm on the 13-th-15-th of July 1982. Aurorae with characteristics typical for auroral curvature were detected twice at the Vostok station on the 14-th of July 1982 at the moment of development of explosive phases of two substorms. Region limited by auroral oval was compressed to the minimum in these periods and it was locatel in the region of dayside cusp

  18. Tomographic Imaging of Water Content and Mine-Induced Stress Distribution in North Aurora, Illinois

    Science.gov (United States)

    Meulemans, A. J.; Fratta, D.; Wang, H. F.

    2013-12-01

    Located in North Aurora, Illinois, the Lafarge-Conco plant is a room-and-pillar mine that is in active production of aggregates, taken from the Galena-Platteville formations. To better understand how stresses are distributed among the pillars over periods of mining production, tomographic images of the interior of the pillar using seismic data collected in November 2012 and March 2013 were created. Seismic tomographic images showed changes in seismic velocity between the two surveys, which is interpreted as change in stress. The southeast corner pillar showed a significant stress increase, and could indicate a possible area of very high stresses within the pillar. While the ground-penetrating radar (GPR) tomographic image was used to assess a very uniform water content and porosity distribution within the pillar. Understanding how stress and moisture distribution changes within pillars during excavation is valuable to mine design and to the maintenance of mine safety.

  19. Dayside aurorae and polar arcs under south-east IMF orientation

    Directory of Open Access Journals (Sweden)

    P. E. Sandholt

    2006-12-01

    Full Text Available We document a characteristic spatial and temporal structure of the aurora in the postnoon sector present during a 10-h-long interval of very steady southeast IMF orientation (clock angle=135° ending in a sharp south-to-north transition. Focus is placed on the detailed morphology of auroral forms/activities corresponding to merging and lobe convection cells obtained from SuperDARN convection data and Greenland magnetograms. The ground optical instruments at Ny Ålesund, Svalbard (76° MLAT recorded different auroral forms/activities as the station moved to higher magnetic local times (MLTs in the 13:00–17:00 MLT sector. Whereas the 13:00–15:00 MLT sector is characterized by classical poleward moving auroral forms (PMAFs associated with merging cell transients, the aurora in the 15:00–17:00 MLT sector shows instead a characteristic latitudinal bifurcation consisting of standard oval forms and polar arcs, and a corresponding composite pattern of merging and lobe convection cells. The merging and lobe cells respond to the southward and northward IMF transitions by activation/fading and fading/activation, respectively. A sequence of brightening events is characterized by successive activations progressing in latitude from the merging cell regime to the lobe cell regime. Emphasis is placed on the association between polar arc brightenings and the activation of the channel of enhanced sunward flow in the lobe cell. The observations are discussed in relation to recent work on solar wind-magnetosphere-ionosphere interconnection topology.

  20. Reconstruction of recent climate change in Alaska from the Aurora Peak ice core, central Alaska

    Science.gov (United States)

    Tsushima, A.; Matoba, S.; Shiraiwa, T.; Okamoto, S.; Sasaki, H.; Solie, D. J.; Yoshikawa, K.

    2015-02-01

    A 180.17 m ice core was drilled at Aurora Peak in the central part of the Alaska Range, Alaska, in 2008 to allow reconstruction of centennial-scale climate change in the northern North Pacific. The 10 m depth temperature in the borehole was -2.2 °C, which corresponded to the annual mean air temperature at the drilling site. In this ice core, there were many melt-refreeze layers due to high temperature and/or strong insolation during summer seasons. We analyzed stable hydrogen isotopes (δD) and chemical species in the ice core. The ice core age was determined by annual counts of δD and seasonal cycles of Na+, and we used reference horizons of tritium peaks in 1963 and 1964, major volcanic eruptions of Mount Spurr in 1992 and Mount Katmai in 1912, and a large forest fire in 2004 as age controls. Here, we show that the chronology of the Aurora Peak ice core from 95.61 m to the top corresponds to the period from 1900 to the summer season of 2008, with a dating error of ± 3 years. We estimated that the mean accumulation rate from 1997 to 2007 (except for 2004) was 2.04 m w.eq. yr-1. Our results suggest that temporal variations in δD and annual accumulation rates are strongly related to shifts in the Pacific Decadal Oscillation index (PDOI). The remarkable increase in annual precipitation since the 1970s has likely been the result of enhanced storm activity associated with shifts in the PDOI during winter in the Gulf of Alaska.

  1. Electrodynamics and energy characteristics of aurora at high resolution by optical methods

    Science.gov (United States)

    Dahlgren, H.; Lanchester, B. S.; Ivchenko, N.; Whiter, D. K.

    2016-06-01

    Technological advances leading to improved sensitivity of optical detectors have revealed that aurora contains a richness of dynamic and thin filamentary structures, but the source of the structured emissions is not fully understood. In addition, high-resolution radar data have indicated that thin auroral arcs can be correlated with highly varying and large electric fields, but the detailed picture of the electrodynamics of auroral filaments is yet incomplete. The Auroral Structure and Kinetics (ASK) instrument is a state-of-the-art ground-based instrument designed to investigate these smallest auroral features at very high spatial and temporal resolution, by using three electron multiplying CCDs in parallel for three different narrow spectral regions. ASK is specifically designed to utilize a new optical technique to determine the ionospheric electric fields. By imaging the long-lived O+ line at 732 nm, the plasma flow in the region can be traced, and since the plasma motion is controlled by the electric field, the field strength and direction can be estimated at unprecedented resolution. The method is a powerful tool to investigate the detailed electrodynamics and current systems around the thin auroral filaments. The two other ASK cameras provide information on the precipitation by imaging prompt emissions, and the emission brightness ratio of the two emissions, together with ion chemistry modeling, is used to give information on the energy and energy flux of the precipitating electrons. In this paper, we discuss these measuring techniques and give a few examples of how they are used to reveal the nature and source of fine-scale structuring in the aurora.

  2. Pitch angle scattering and particle precipitation in a pulsating aurora - an experimental study

    International Nuclear Information System (INIS)

    A pulsating aurora occurring during the recovery phase of a substorm on January 27, 1979 was monitored by a large set of instruments. The Swedish sounding rocket S23-L2 was launched at magnetic midnight over pulsating patches, some of which exhibited 3+-1 Hz modulation. The ground based instrumentation included auroral TV cameras, all sky cameras, photometers and magnetometers. The geostationary satellite GEOS-2 was located in the equatorial plane, approximately conjugate to the rocket. The central experiment of this study is the particle experiment on the rocket. Several aspects of pulsating auroras have been investigated. The auroral luminosity variations were very well correlated to variations in the flux of precipitating hot electrons. The 1-20 second pulsations were caused by increased fluxes of 4-40 keV electrons. The 3+-1 Hz modulation was detected in 7-200 keV electrons, but the biggest energy flux modulation occurred for electrons of about 60 keV. Model calculations involving the electron distributions measured by the sounding rocket and GEOS-2, consistently show that the electrons may have been scattered into the loss cone through the Doppler shifted gyroresonance with whistler mode waves. The scattering was not a pure pitch angle scattering as in the classical Coroniti and Kennel theory, but involved also a systematic energy loss from the particles. The waves were probably hiss with some chorus elements. The equatorial plane plasma density was estimated in two independent ways to be about 2x106 m-3. The 3+-1 Hz modulation was measured both by the particle experiment on the rocket and by the wave experiment on GEOS-2. Properties of the modulated fluxes are described and a qualitative model for the cause of the modulation is proposed. (author)

  3. Distribution of energetic positive ion species above a diffuse midnight aurora

    International Nuclear Information System (INIS)

    Observational approaches to the problem of magnetospheric plasma origin usually depend upon mass-discriminating measurements of ion distribution functions. A new instrument for this purpose has been developed and flown via sounding rockets above a diffuse midnight aurora during geomagnetically quiet conditions. The instrument combines wide mass and energy ranges (2.5+ and He++ were detected, and the He++ was not clearly above background, having an upper limit of 2--4% of the H+ intensity. All other ions, including the ionospheric species He+ and O+, had upper limits at a similar or smaller level. This situation contrasts sharply with a number of recently reported observations of large intensities of O+ during magnetic storms and may be characteristic of undisturbed periods. Though these results suggest a solar wind source for the ions, an admixture including an appreciable fraction of polar wind material (predominantly H+) is not precluded. The measured proton distribution was nearly isotropic over downcoming pitch angles at all energies and showed a depleted atmospheric source cone. The proton energy distribution had a best fit temperature of 4.5 keV and a number density of 0.17 cm-3, corresponding to a peak intensity just over 105 cm-2 s-1 keV-1. Altitudinal variations observed during the flight are consistent with the theory of charge exchange of a time steady incident proton population. These ion observations, taken together with electron observations reported in a companion paper, appear to be consistent with the model of diffuse auroras in which trapped plasma precipitates owing to strong pitch angle diffusion on auroral field lines linking the near-earth plasma sheet

  4. Modeling Spectra of the North and South Jovian X-ray Auroras

    International Nuclear Information System (INIS)

    Spectra of Jovian X-ray auroras observed from the North and South poles with the Chandra X-ray telescope are analyzed and compared with predicted spectra of the charge-exchange mechanism. To determine the theoretical spectra of Jovian X-ray auroras, we model numerically the collisionally induced evolution of energy and charge distributions of Oq+ and Sq+ ions, precipitating into the Jovian atmosphere. Monte Carlo simulations of the energy and charge relaxation of the precipitating ions are carried out with updated cross-sections of the ion stripping, electron capture, and gas-ionization collisions. X-ray and Extreme Ultraviolet (EUV) spectra of cascading radiation induced by individual energetic sulfur and oxygen ions are calculated, and relative intensities of X-ray emission lines are determined. Synthetic spectra of X-ray and EUV photons are computed at different initial kinetic energies and compositions of ion-precipitating fluxes. Theoretical spectra with adjustable initial energies and relative fraction of sulfur and oxygen ions are shown to be in good agreement with the spectra of X rays detected from the South and North polar regions. The abundances and initial energies of the precipitating ions are inferred by comparing synthetic and observed X-ray spectra. Comparisons are performed independently for the North and South pole emissions. Abundances of the precipitating sulfur ions are found to be four to five times smaller than those of oxygen ions, and averaged ion energies are determined to lie between 1 and 2 MeV/amu. Slightly different ion flux compositions are found to describe the observed spectra of X-ray emission from the North and South poles

  5. The Cassini Campaign observations of the Jupiter aurora by the Ultraviolet Imaging Spectrograph and the Space Telescope Imaging Spectrograph

    Science.gov (United States)

    Ajello, Joseph M.; Pryor, Wayne; Esposito, Larry; Stewart, Ian; McClintock, William; Gustin, Jacques; Grodent, Denis; Gérard, J.-C.; Clarke, John T.

    2005-11-01

    We have analyzed the Cassini Ultraviolet Imaging Spectrometer (UVIS) observations of the Jupiter aurora with an auroral atmosphere two-stream electron transport code. The observations of Jupiter by UVIS took place during the Cassini Campaign. The Cassini Campaign included support spectral and imaging observations by the Hubble Space Telescope (HST) Space Telescope Imaging Spectrograph (STIS). A major result for the UVIS observations was the identification of a large color variation between the far ultraviolet (FUV: 1100-1700 Å) and extreme ultraviolet (EUV: 800-1100 Å) spectral regions. This change probably occurs because of a large variation in the ratio of the soft electron flux (10-3000 eV) responsible for the EUV aurora to the hard electron flux (˜15-22 keV) responsible for the FUV aurora. On the basis of this result a new color ratio for integrated intensities for EUV and FUV was defined ( 4πI/4πI) which varied by approximately a factor of 6. The FUV color ratio ( 4πI/4πI) was more stable with a variation of less than 50% for the observations studied. The medium resolution (0.9 Å FWHM, G140M grating) FUV observations (1295-1345 Å and 1495-1540 Å) by STIS on 13 January 2001, on the other hand, were analyzed by a spectral modeling technique using a recently developed high-spectral resolution model for the electron-excited H 2 rotational lines. The STIS FUV data were analyzed with a model that considered the Lyman band spectrum (B Σu+1→XΣg+1) as composed of an allowed direct excitation component (X Σg+1→BΣu+1) and an optically forbidden component (X Σg+1→EF,GK,HH¯,…Σg+1 followed by the cascade transition Σg+1→BΣu+1). The medium-resolution spectral regions for the Jupiter aurora were carefully chosen to emphasize the cascade component. The ratio of the two components is a direct measurement of the mean secondary electron energy of the aurora. The mean secondary electron energy of the aurora varies between 50 and 200 eV for the polar

  6. Inhibition of Aurora-A kinase induces cell cycle arrest in epithelial ovarian cancer stem cells by affecting NFκB pathway

    OpenAIRE

    Chefetz, Ilana; Holmberg, Jennie C.; Alvero, Ayesha B.; Visintin, Irene; Mor, Gil

    2011-01-01

    Recurrent ovarian cancer is resistant to conventional chemotherapy. A sub-population of ovarian cancer cells, the epithelial ovarian cancer stem cells (EOC stem cells) have stemness properties, constitutive NFκB activity, and represent the chemoresistant population. Currently, there is no effective treatment that targets these cells. Aurora-A kinase (Aurora-A) is associated with tumor initiation and progression and is overexpressed in numerous malignancies. The aim of this study is to determi...

  7. Bioactive compounds of Eriocaulon sieboldianum blocking proliferation and inducing apoptosis of HepG2 cells might be involved in Aurora kinase inhibition.

    Science.gov (United States)

    Fan, Yanhua; Lu, Hongyuan; Ma, Hongda; Feng, Fan; Hu, Xiaolong; Zhang, Qiao; Wang, Jian; Xu, Yongnan; Zhao, Qingchun

    2015-12-01

    Eriocaulon sieboldianum (Sieb. & Zucc. ex Steud.) is an edible and medicinal plant used in traditional Chinese medicine. Often in combination with other herbs, it is processed into healthcare beverages for expelling wind-heat, protecting eyes, and reducing blood lipids. Besides, its water decoction together with other herbs has been utilized to treat cancer in China. However, the active ingredients and the precise cellular mechanisms of E. sieboldianum remain to be elucidated. The Aurora kinase family plays critical roles in the regulation of cell division and has attracted great attention to the identification of small-molecule Aurora kinase inhibitors for potential treatment of cancer. A molecular docking study was employed for docking of the most bioactive compounds. Hispidulin (HPDL) and quercetin-3-O-(6''-O-galloyl)-β-D-galactopyranoside (QGGP) were singled out as potent inhibitors of Aurora kinase. Their inhibitory activity towards Aurora kinase was further confirmed by the obvious decrease in autophosphorylation of Aurora-A (Thr288) and Aurora-B (Thr232). Moreover, the induction of cell cycle arrest in HepG2 cells and the suppressed phosphorylation of histone H3 were also consistent with the inhibition of Aurora kinase. The data indicate that the E. sieboldianum extract and its two active compounds, HPDL and QGGP, could effectively induce apoptosis via p53, MAPKs and the mitochondrial apoptotic pathways. These findings could improve the understanding and enhance the development of drugs based on E. sieboldianum and raise its application value in anticancer therapy or prevention. In addition, our results indicated that Aurora kinase might be a novel target of HPDL and QGGP. PMID:26369427

  8. Nuclear epidermal growth factor receptor (EGFR) interacts with signal transducer and activator of transcription 5 (STAT5) in activating Aurora-A gene expression

    OpenAIRE

    Hung, Liang-Yi; Tseng, Joseph T.; Lee, Yi-Chao; Xia, Weiya; Wang, Ying-Nai; Wu, Min-Li; Chuang, Yu-Hsuan; Lai, Chein-Hsien; Chang, Wen-Chang

    2008-01-01

    Loss of the maintenance of genetic material is a critical step leading to tumorigenesis. It was reported that overexpression of Aurora-A and the constitutive activation of the epidermal growth factor (EGF) receptor (EGFR) are implicated in chromosome instability. In this study, we examined that when cells treated with EGF result in centrosome amplification and microtubule disorder, which are critical for genetic instability. Interestingly, the expression of Aurora-A was also increased by EGF ...

  9. Aurora kinases are expressed in medullary thyroid carcinoma (MTC) and their inhibition suppresses in vitro growth and tumorigenicity of the MTC derived cell line TT

    International Nuclear Information System (INIS)

    The Aurora kinase family members, Aurora-A, -B and -C, are involved in the regulation of mitosis, and alterations in their expression are associated with cell malignant transformation. To date no information on the expression of these proteins in medullary thyroid carcinoma (MTC) are available. We here investigated the expression of the Aurora kinases in human MTC tissues and their potential use as therapeutic targets. The expression of the Aurora kinases in 26 MTC tissues at different TNM stages was analyzed at the mRNA level by quantitative RT-PCR. We then evaluated the effects of the Aurora kinase inhibitor MK-0457 on the MTC derived TT cell line proliferation, apoptosis, soft agar colony formation, cell cycle and ploidy. The results showed the absence of correlation between tumor tissue levels of any Aurora kinase and tumor stage indicating the lack of prognostic value for these proteins. Treatment with MK-0457 inhibited TT cell proliferation in a time- and dose-dependent manner with IC50 = 49.8 ± 6.6 nM, as well as Aurora kinases phosphorylation of substrates relevant to the mitotic progression. Time-lapse experiments demonstrated that MK-0457-treated cells entered mitosis but were unable to complete it. Cytofluorimetric analysis confirmed that MK-0457 induced accumulation of cells with ≥ 4N DNA content without inducing apoptosis. Finally, MK-0457 prevented the capability of the TT cells to form colonies in soft agar. We demonstrate that Aurora kinases inhibition hampered growth and tumorigenicity of TT cells, suggesting its potential therapeutic value for MTC treatment

  10. Aurora kinases are expressed in medullary thyroid carcinoma (MTC and their inhibition suppresses in vitro growth and tumorigenicity of the MTC derived cell line TT

    Directory of Open Access Journals (Sweden)

    Morrone Stefania

    2011-09-01

    Full Text Available Abstract Background The Aurora kinase family members, Aurora-A, -B and -C, are involved in the regulation of mitosis, and alterations in their expression are associated with cell malignant transformation. To date no information on the expression of these proteins in medullary thyroid carcinoma (MTC are available. We here investigated the expression of the Aurora kinases in human MTC tissues and their potential use as therapeutic targets. Methods The expression of the Aurora kinases in 26 MTC tissues at different TNM stages was analyzed at the mRNA level by quantitative RT-PCR. We then evaluated the effects of the Aurora kinase inhibitor MK-0457 on the MTC derived TT cell line proliferation, apoptosis, soft agar colony formation, cell cycle and ploidy. Results The results showed the absence of correlation between tumor tissue levels of any Aurora kinase and tumor stage indicating the lack of prognostic value for these proteins. Treatment with MK-0457 inhibited TT cell proliferation in a time- and dose-dependent manner with IC50 = 49.8 ± 6.6 nM, as well as Aurora kinases phosphorylation of substrates relevant to the mitotic progression. Time-lapse experiments demonstrated that MK-0457-treated cells entered mitosis but were unable to complete it. Cytofluorimetric analysis confirmed that MK-0457 induced accumulation of cells with ≥ 4N DNA content without inducing apoptosis. Finally, MK-0457 prevented the capability of the TT cells to form colonies in soft agar. Conclusions We demonstrate that Aurora kinases inhibition hampered growth and tumorigenicity of TT cells, suggesting its potential therapeutic value for MTC treatment.

  11. Aurora-B and HDAC synergistically regulate survival and proliferation of lymphoma cell via AKT, mTOR and Notch pathways.

    Science.gov (United States)

    Wang, Chong; Chen, Jing; Cao, Weijie; Sun, Ling; Sun, Hui; Liu, Yanfang

    2016-05-15

    Aurora-B is a protein kinase that functions mainly in the attachment of the mitotic spindle to the centromere. Overexpression of Aurora-B causes unequal distribution of genetic information, creating aneuploidy cells, a hallmark of cancer. Histone deacetylases (HDACs) are a class of enzymes that remove acetyl groups from a ε-N-acetyl lysine amino acid on a histone, allowing the histones to wrap the DNA more tightly, thus globally regulating gene transcription. Additionally, these HDACs can also modify non-histone proteins. Inhibition of HDACs is a potent strategy for cancer treatment. Here, we report that inhibition of Aurora-B and HDAC exerts similar tumor suppressive effects in cells. Knockdown of Aurora-B or inhibition of HDAC achieved the same effect on repression of cell proliferation. Furthermore, we found that the tumor suppressive effect of Aurora-B and HDAC inhibition is due to the induction of cell cycle arrest and/or apoptosis. Mechanistically, we demonstrated that Aurora-B and HDAC can cooperatively regulate AKT, mTOR and Notch pathways. PMID:26638998

  12. Experimental facilities

    International Nuclear Information System (INIS)

    We have completed an engineering feasibility study of a major modification of the HFIR facility and are now beginning a similar study of an entirely new facility. The design of the reactor itself is common to both options. In this paper, a general description of the modified HFIR is presented with some indications of the additional facilities that might be available in an entirely new facility

  13. A real-time hybrid aurora alert system: Combining citizen science reports with an auroral oval model

    Science.gov (United States)

    Case, N. A.; Kingman, D.; MacDonald, E. A.

    2016-06-01

    Accurately predicting when, and from where, an aurora will be visible is particularly difficult, yet it is a service much desired by the general public. Several aurora alert services exist that attempt to provide such predictions but are, generally, based upon fairly coarse estimates of auroral activity (e.g., Kp or Dst). Additionally, these services are not able to account for a potential observer's local conditions (such as cloud cover or level of darkness). Aurorasaurus, however, combines data from the well-used, solar wind-driven, OVATION Prime auroral oval model with real-time observational data provided by a global network of citizen scientists. This system is designed to provide more accurate and localized alerts for auroral visibility than currently available. Early results are promising and show that over 100,000 auroral visibility alerts have been issued, including nearly 200 highly localized alerts, to over 2000 users located right across the globe.

  14. Self-consistent electrostatic simulations of reforming double layers in the downward current region of the aurora

    OpenAIRE

    H. Gunell; Andersson, L.; De Keyser, J; I. Mann

    2015-01-01

    The plasma on a magnetic field line in the downward current region of the aurora is simulated using a Vlasov model. It is found that an electric field parallel to the magnetic fields is supported by a double layer moving toward higher altitude. The double layer accelerates electrons upward, and these electrons give rise to plasma waves and electron phase-space holes through beam–plasma interaction. The double layer is disrupted when reaching altitudes of 1–2 Earth r...

  15. Aurora Tropical”: a model of Ecological Horticulture, Case studies of 11 Onion and Shallot cultivars

    OpenAIRE

    Ramirez-Guerrero, Hugo; Moyeeja-Guerrero, J.; Renaud-Rodriguez, D.; Paz-Leon, R.; Lugo-Gonzalez, J.; Anzalone-Grazi, A.

    2008-01-01

    A proposal is presented for a model programme of ecological horticulture which could contribute to improved vegetable crop production and biodiversity in tropical agroecosystems. Each step of the model “Aurora Tropical” was successfully applied for producing pesticide-free onions and shallots in semiarid conditions of Venezuela and for comparing simultaneously growth and productivity of 11 cultivars. The model steps include a good knowledge of the vegetable crop, market, soil/substrate, irrig...

  16. v-Src causes delocalization of Mklp1, Aurora B, and INCENP from the spindle midzone during cytokinesis failure

    Energy Technology Data Exchange (ETDEWEB)

    Soeda, Shuhei [Department of Molecular Cell Biology, Graduate School of Pharmaceutical Sciences, Chiba University, Inohana 1-8-1, Chuo-ku, Chiba 260-8675 (Japan); Nakayama, Yuji, E-mail: nakayama@mb.kyoto-phu.ac.jp [Department of Molecular Cell Biology, Graduate School of Pharmaceutical Sciences, Chiba University, Inohana 1-8-1, Chuo-ku, Chiba 260-8675 (Japan); Department of Biochemistry and Molecular Biology, Kyoto Pharmaceutical University, 5 Nakauchi-cho, Misasagi, Yamashina-ku, Kyoto 607-8414 (Japan); Honda, Takuya; Aoki, Azumi; Tamura, Naoki; Abe, Kohei; Fukumoto, Yasunori [Department of Molecular Cell Biology, Graduate School of Pharmaceutical Sciences, Chiba University, Inohana 1-8-1, Chuo-ku, Chiba 260-8675 (Japan); Yamaguchi, Naoto, E-mail: nyama@faculty.chiba-u.jp [Department of Molecular Cell Biology, Graduate School of Pharmaceutical Sciences, Chiba University, Inohana 1-8-1, Chuo-ku, Chiba 260-8675 (Japan)

    2013-06-10

    Src-family tyrosine kinases are aberrantly activated in cancers, and this activation is associated with malignant tumor progression. v-Src, encoded by the v-src transforming gene of the Rous sarcoma virus, is a mutant variant of the cellular proto-oncogene c-Src. Although investigations with temperature sensitive mutants of v-Src have shown that v-Src induces many oncogenic processes, the effects on cell division are unknown. Here, we show that v-Src inhibits cellular proliferation of HCT116, HeLa S3 and NIH3T3 cells. Flow cytometry analysis indicated that inducible expression of v-Src results in an accumulation of 4N cells. Time-lapse analysis revealed that binucleation is induced through the inhibition of cytokinesis, a final step of cell division. The localization of Mklp1, which is essential for cytokinesis, to the spindle midzone is inhibited in v-Src-expressing cells. Intriguingly, Aurora B, which regulates Mklp1 localization at the midzone, is delocalized from the spindle midzone and the midbody but not from the metaphase chromosomes upon v-Src expression. Mklp2, which is responsible for the relocation of Aurora B from the metaphase chromosomes to the spindle midzone, is also lost from the spindle midzone. These results suggest that v-Src inhibits cytokinesis through the delocalization of Mklp1 and Aurora B from the spindle midzone, resulting in binucleation. -- Highlights: • v-Src inhibits cell proliferation of HCT116, HeLa S3 and NIH3T3 cells. • v-Src induces binucleation together with cytokinesis failure. • v-Src causes delocalization of Mklp1, Aurora B and INCENP from the spindle midzone.

  17. The conserved apicomplexan Aurora kinase TgArk3 is involved in endodyogeny, duplication rate and parasite virulence.

    Science.gov (United States)

    Berry, Laurence; Chen, Chun-Ti; Reininger, Luc; Carvalho, Teresa G; El Hajj, Hiba; Morlon-Guyot, Juliette; Bordat, Yann; Lebrun, Maryse; Gubbels, Marc-Jan; Doerig, Christian; Daher, Wassim

    2016-08-01

    Aurora kinases are eukaryotic serine/threonine protein kinases that regulate key events associated with chromatin condensation, centrosome and spindle function and cytokinesis. Elucidating the roles of Aurora kinases in apicomplexan parasites is crucial to understand the cell cycle control during Plasmodium schizogony or Toxoplasma endodyogeny. Here, we report on the localization of two previously uncharacterized Toxoplasma Aurora-related kinases (Ark2 and Ark3) in tachyzoites and of the uncharacterized Ark3 orthologue in Plasmodium falciparum erythrocytic stages. In Toxoplasma gondii, we show that TgArk2 and TgArk3 concentrate at specific sub-cellular structures linked to parasite division: the mitotic spindle and intranuclear mitotic structures (TgArk2), and the outer core of the centrosome and the budding daughter cells cytoskeleton (TgArk3). By tagging the endogenous PfArk3 gene with the green fluorescent protein in live parasites, we show that PfArk3 protein expression peaks late in schizogony and localizes at the periphery of budding schizonts. Disruption of the TgArk2 gene reveals no essential function for tachyzoite propagation in vitro, which is surprising giving that the P. falciparum and P. berghei orthologues are essential for erythrocyte schizogony. In contrast, knock-down of TgArk3 protein results in pronounced defects in parasite division and a major growth deficiency. TgArk3-depleted parasites display several defects, such as reduced parasite growth rate, delayed egress and parasite duplication, defect in rosette formation, reduced parasite size and invasion efficiency and lack of virulence in mice. Our study provides new insights into cell cycle control in Toxoplasma and malaria parasites and highlights Aurora kinase 3 as potential drug target. PMID:26833682

  18. Ipl1/Aurora-dependent phosphorylation of Sli15/INCENP regulates CPC–spindle interaction to ensure proper microtubule dynamics

    OpenAIRE

    Nakajima, Yuko; Cormier, Anthony; Tyers, Randall G.; Pigula, Adrianne; Peng, Yutian; Drubin, David G; Barnes, Georjana

    2011-01-01

    Dynamic microtubules facilitate chromosome arrangement before anaphase, whereas during anaphase microtubule stability assists chromosome separation. Changes in microtubule dynamics at the metaphase–anaphase transition are regulated by Cdk1. Cdk1-mediated phosphorylation of Sli15/INCENP promotes preanaphase microtubule dynamics by preventing chromosomal passenger complex (CPC; Sli15/INCENP, Bir1/Survivin, Nbl1/Borealin, Ipl1/Aurora) association with spindles. However, whether Cdk1 has sole con...

  19. Ipl1/Aurora B kinase coordinates synaptonemal complex disassembly with cell cycle progression and crossover formation in budding yeast meiosis

    OpenAIRE

    Jordan, Philip; Copsey, Alice; Newnham, Louise; Kolar, E; Lichten, M; Hoffmann, Eva

    2009-01-01

    Several protein kinases collaborate to orchestrate and integrate cellular and chromosomal events at the G2/M transition in both mitotic and meiotic cells. During the G2/M transition in meiosis, this includes the completion of crossover recombination, spindle formation, and synaptonemal complex (SC) breakdown. We identified Ipl1/Aurora B kinase as the main regulator of SC disassembly. Mutants lacking Ipl1 or its kinase activity assemble SCs with normal timing, but fail to dissociate the centra...

  20. Glc7/Protein Phosphatase 1 Regulatory Subunits Can Oppose the Ipl1/Aurora Protein Kinase by Redistributing Glc7

    OpenAIRE

    Pinsky, Benjamin A.; Kotwaliwale, Chitra V.; Tatsutani, Sean Y.; Breed, Christopher A.; Biggins, Sue

    2006-01-01

    Faithful chromosome segregation depends on the opposing activities of the budding yeast Glc7/PP1 protein phosphatase and Ipl1/Aurora protein kinase. We explored the relationship between Glc7 and Ipl1 and found that the phosphorylation of the Ipl1 substrate, Dam1, was altered by decreased Glc7 activity, whereas Ipl1 levels, localization, and kinase activity were not. These data strongly suggest that Glc7 ensures accurate chromosome segregation by dephosphorylating Ipl1 targets rather than regu...

  1. The budding yeast protein kinase Ipl1/Aurora allows the absence of tension to activate the spindle checkpoint

    OpenAIRE

    Biggins, Sue; Murray, Andrew W.

    2001-01-01

    The spindle checkpoint prevents cell cycle progression in cells that have mitotic spindle defects. Although several spindle defects activate the spindle checkpoint, the exact nature of the primary signal is unknown. We have found that the budding yeast member of the Aurora protein kinase family, Ipl1p, is required to maintain a subset of spindle checkpoint arrests. Ipl1p is required to maintain the spindle checkpoint that is induced by overexpression of the protein kinase Mps1. Inactivating I...

  2. Relation between fine structure of energy spectra for pulsating aurora electrons and frequency spectra of whistler mode chorus waves

    Czech Academy of Sciences Publication Activity Database

    Miyoshi, Y.; Saito, S.; Seki, K.; Nishiyama, T.; Kataoka, R.; Asamura, K.; Katoh, Y.; Ebihara, Y.; Sakanoi, T.; Hirahara, M.; Oyama, S.; Kurita, S.; Santolík, Ondřej

    2015-01-01

    Roč. 120, č. 9 (2015), s. 7728-7736. ISSN 2169-9380 R&D Projects: GA MŠk LH12231 Institutional support: RVO:68378289 Keywords : pulsating aurora * chorus waves * wave-particle interactions * computer simulation * Reimei satellite Subject RIV: DG - Athmosphere Sciences, Meteorology Impact factor: 3.440, year: 2013 http://onlinelibrary.wiley.com/doi/10.1002/2015JA021562/full

  3. Combining the pan-aurora kinase inhibitor AMG 900 with histone deacetylase inhibitors enhances antitumor activity in prostate cancer

    International Nuclear Information System (INIS)

    Histone deacetylase inhibitors (HDACIs) are being tested in clinical trials for the treatment of solid tumors. While most studies have focused on the reexpression of silenced tumor suppressor genes, a number of genes/pathways are downregulated by HDACIs. This provides opportunities for combination therapy: agents that further disable these pathways through inhibition of residual gene function are speculated to enhance cell death in combination with HDACIs. A previous study from our group indicated that mitotic checkpoint kinases such as PLK1 and Aurora A are downregulated by HDACIs. We used in vitro and in vivo xenograft models of prostate cancer (PCA) to test whether combination of HDACIs with the pan-aurora kinase inhibitor AMG 900 can synergistically or additively kill PCA cells. AMG 900 and HDACIs synergistically decreased cell proliferation activity and clonogenic survival in DU-145, LNCaP, and PC3 PCA cell lines compared to single-agent treatment. Cellular senescence, polyploidy, and apoptosis was significantly increased in all cell lines after combination treatment. In vivo xenograft studies indicated decreased tumor growth and decreased aurora B kinase activity in mice treated with low-dose AMG 900 and vorinostat compared to either agent alone. Pharmacodynamics was assessed by scoring for phosphorylated histone H3 through immunofluorescence. Our results indicate that combination treatment with low doses of AMG 900 and HDACIs could be a promising therapy for future clinical trials against PCA

  4. The JUPITER and AURORA clinical trials for rosuvastatin in special primary prevention populations: perspectives, outcomes, and consequences

    Directory of Open Access Journals (Sweden)

    Venkata Narla

    2009-11-01

    Full Text Available Venkata Narla, Michael J Blaha, Roger S Blumenthal, Erin D MichosThe Ciccarone Preventive Cardiology Center, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD, USAAbstract: Statins have emerged at the forefront of preventive cardiology and have significantly reduced cardiovascular events and mortality. Nonetheless, cardiovascular disease remains the leading cause of death in the United States and in other developed countries, as well as the etiology of significant morbidity and health-care expenditure. In an attempt to reduce potentially missed opportunities for instituting preventive therapy, the JUPITER study (Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin and the AURORA study (A Study to Evaluate the Use of Rosuvastatin in Subjects on Regular Hemodialysis: An Assessment of Survival and Cardiovascular Events examined the effect of statins in two specific patient populations who currently do not meet the guidelines for statin treatment, but nonetheless, are at high cardiovascular risk. This review outlines the JUPITER and AURORA trials, interprets the data and significance of the results, analyses the drawbacks and impact of both trials and delineates the potential for further clinical trials.Keywords: JUPITER, AURORA, rosuvastatin, cardiovascular disease

  5. Aurora kinases as druggable targets in pediatric leukemia: heterogeneity in target modulation activities and cytotoxicity by diverse novel therapeutic agents.

    Directory of Open Access Journals (Sweden)

    Aarthi Jayanthan

    Full Text Available Leukemia is the most common pediatric malignancy, constituting more than 30% of all childhood cancers. Although cure rates have improved greatly, approximately one in five children relapse and poor survival rates post relapse remain a challenge. Given this, more effective and innovative therapeutic strategies are needed in order to improve prognosis. Aurora kinases, a family of serine/threonine kinases essential for the regulation of several mitotic processes, have been identified as potential targets for cancer therapeutics. Elevated expression of Aurora kinases has been demonstrated in several malignancies and is associated with aberrant mitotic activity, aneuploidy and alterations in chromosomal structure and genome instability. Based on this rationale, a number of small molecule inhibitors have been formulated and advanced to human studies in the recent past. A comparative analysis of these agents in cytotoxicity and target modulation analyses against a panel of leukemia cells provides novel insights into the unique mechanisms and codependent activity pathways involved in targeting Aurora kinases, constituting a distinctive preclinical experimental framework to identify appropriate agents and combinations in future clinical studies.

  6. Antifouling activity by sea anemone (Heteractis magnifica and H. aurora extracts against marine biofilm bacteria Actividades antiincrustantes de las extractos de las anémonas marinas Heteractis magnifica y H. aurora frente a biofilm de bacterias marinas

    Directory of Open Access Journals (Sweden)

    Subramanian Bragadeeswaran

    2011-07-01

    Full Text Available Sea anemones (Actiniaria are solitary, ocean-dwelling members of the phylum Cnidaria and the class Anthozoa. In this study, we screened antibacterial activity of two benthic sea anemones (Heteractis magnifica and H. aurora collected from the Mandapam coast of southeast India. Crude extracts of the sea anemone were assayed against seven bacterial biofilms isolated from three different test panels. The crude extract of H. magnifica showed a maximum inhibition zone of 18 mm against Pseudomonas sp. and Escherichia coli and a minimum inhibition zone of 3 mm against Pseudomonas aeruginosa, Micrococcus sp., and Bacillus cerens for methanol, acetone, and DCM extracts, respectively. The butanol extract of H. aurora showed a maximum inhibition zone of 23 mm against Vibrio parahaemolyticus, whereas the methanol extract revealed a minimum inhibition zone of 1 mm against V. parahaemolyticus. The present study revealed that the H. aurora extracts were more effective than those of H. magnifica and that the active compounds from the sea anemone can be used as antifouling compounds.Las anémonas de mar (Actiniaria son solitarias, habitantes oceánicos del phylum Cnidaria y de la clase Anthozoa. En este estudio se determina la actividad antibacteriana de dos anémonas bentónicas Heteractis magnifica y H. aurora recolectadas en la costa de Mandapam, sudeste de India. Los extractos crudos de estas anémonas fueron ensayados frente a siete biofilms bacterianos aislados de tres paneles de control distintos. El extracto crudo de la anémona H. magnifica mostró una zona inhibición máxima de 18 mm contra Psudomonas sp. y Escherichia coli y la zona de inhibición mínima de 3 mm fue encontrada frente a Pseudomonas aeruginosa, Micrococus sp. y Bacillus cerens de extractos de metanol, acetona y DCM respectivamente. El extracto de butanol de la anémona H. magnifica mostró una zona de inhibición máxima de 23 mm frente a Vibrio parahemolyticus, mientras que con el

  7. Dayside Proton Aurora: Comparisons between Global MHD Simulations and Image Observations

    Science.gov (United States)

    Berchem, J.; Fuselier, S. A.; Petrinec, S.; Frey, H. U.; Burch, J. L.

    2003-01-01

    The IMAGE mission provides a unique opportunity to evaluate the accuracy of current global models of the solar wind interaction with the Earth's magnetosphere. In particular, images of proton auroras from the Far Ultraviolet Instrument (FUV) onboard the IMAGE spacecraft are well suited to support investigations of the response of the Earth's magnetosphere to interplanetary disturbances. Accordingly, we have modeled two events that occurred on June 8 and July 28, 2000, using plasma and magnetic field parameters measured upstream of the bow shock as input to three-dimensional magnetohydrodynamic (MHD) simulations. This paper begins with a discussion of images of proton auroras from the FUV SI-12 instrument in comparison with the simulation results. The comparison showed a very good agreement between intensifications in the auroral emissions measured by FUV SI-12 and the enhancement of plasma flows into the dayside ionosphere predicted by the global simulations. Subsequently, the IMAGE observations are analyzed in the context of the dayside magnetosphere's topological changes in magnetic field and plasma flows inferred from the simulation results. Finding include that the global dynamics of the auroral proton precipitation patterns observed by IMAGE are consistent with magnetic field reconnection occurring as a continuous process while the iMF changes in direction and the solar wind dynamic pressure varies. The global simulations also indicate that some of the transient patterns observed by IMAGE are consistent with sporadic reconnection processes. Global merging patterns found in the simulations agree with the antiparallel merging model. though locally component merging might broaden the merging region, especially in the region where shocked solar wind discontinuities first reach the magnetopause. Finally, the simulations predict the accretion of plasma near the bow shock in the regions threaded by newly open field lines on which plasma flows into the dayside

  8. A statistical analysis of the location and width of Saturn's southern auroras

    Directory of Open Access Journals (Sweden)

    S. V. Badman

    2006-12-01

    Full Text Available A selection of twenty-two Hubble Space Telescope images of Saturn's ultraviolet auroras obtained during 1997–2004 has been analysed to determine the median location and width of the auroral oval, and their variability. Limitations of coverage restrict the analysis to the southern hemisphere, and to local times from the post-midnight sector to just past dusk, via dawn and noon. It is found that the overall median location of the poleward and equatorward boundaries of the oval with respect to the southern pole are at ~14° and ~16° co-latitude, respectively, with a median latitudinal width of ~2°. These median values vary only modestly with local time around the oval, though the poleward boundary moves closer to the pole near noon (~12.5° such that the oval is wider in that sector (median width ~3.5° than it is at both dawn and dusk (~1.5°. It is also shown that the position of the auroral boundaries at Saturn are extremely variable, the poleward boundary being located between 2° and 20° co-latitude, and the equatorward boundary between 6° and 23°, this variability contrasting sharply with the essentially fixed location of the main oval at Jupiter. Comparison with Voyager plasma angular velocity data mapped magnetically from the equatorial magnetosphere into the southern ionosphere indicates that the dayside aurora lie poleward of the main upward-directed field-aligned current region associated with corotation enforcement, which maps to ~20°–24° co-latitude, while agreeing reasonably with the position of the open-closed field line boundary based on estimates of the open flux in Saturn's tail, located between ~11° and ~15°. In this case, the variability in location can be understood in terms of changes in the open flux present in the system, the changes implied by the Saturn data then matching those observed at Earth as fractions of the total planetary flux. We infer that the broad (few degrees diffuse auroral emissions

  9. Alfvén Waves and the Aurora (Hannes Alfvén Medal Lecture)

    Science.gov (United States)

    Lysak, Robert

    2015-04-01

    The most compelling visual evidence of plasma processes in the magnetosphere of Earth as well as the other magnetized planets is the aurora. Over 40 years of research have indicated that the aurora is a consequence of the acceleration of charged particles toward the neutral atmosphere, where the excitation of neutral atoms and their subsequent relaxation to the ground state produces the auroral light. Much of this acceleration can be described by acceleration in a quasi-static electric field parallel to the geomagnetic field, producing nearly monoenergetic beams of electrons. While a variety of quasi-static models to describe such parallel electric fields have been developed, the dynamics of how these fields evolve is still an open question. Satellite measurements have indicated that a primary source of energy to support these fields is the Poynting flux associated with shear Alfvén waves propagating along auroral field lines. These Alfvén waves are generated in the magnetosphere and reflect from the ionosphere. On closed field lines, Alfvén waves bouncing between conjugate ionospheres produce field line resonances that have be observed both in space and by ground magnetometers. However, some auroral emissions do not follow this scenario. In these cases, the accelerated electrons are observed to have a broad energy spectrum, rather than a monoenergetic peak. Such a spectrum is suggestive of a time-dependent acceleration process that operates on a time scale of a few seconds, comparable to the electron transit time across the acceleration region. While field line resonances have a time scale on the order of minutes, waves with periods of a few seconds can be produced by partial reflections in the Ionospheric Alfvén Resonator, a resonant cavity formed by the rapid decrease of the plasma density and increase of the Alfvén speed above the ionosphere. In order to develop a parallel electric field that can accelerate auroral particles, these Alfvén waves must

  10. Animal facilities

    International Nuclear Information System (INIS)

    The animal facilities in the Division are described. They consist of kennels, animal rooms, service areas, and technical areas (examining rooms, operating rooms, pathology labs, x-ray rooms, and 60Co exposure facilities). The computer support facility is also described. The advent of the Conversational Monitor System at Argonne has launched a new effort to set up conversational computing and graphics software for users. The existing LS-11 data acquisition systems have been further enhanced and expanded. The divisional radiation facilities include a number of gamma, neutron, and x-ray radiation sources with accompanying areas for related equipment. There are five 60Co irradiation facilities; a research reactor, Janus, is a source for fission-spectrum neutrons; two other neutron sources in the Chicago area are also available to the staff for cell biology studies. The electron microscope facilities are also described

  11. Aurora: A short-pulse multikilojoule KrF inertial fusion laser system

    International Nuclear Information System (INIS)

    Aurora is a laser system that serves as an operating technology demonstration prototype for large-scale high-energy KrF laser systems of interest for inertial fusion applications. This system will incorporate the following elements to achieve an end-to-end 248-nm laser fusion concept demonstration: an injection-locked oscillator-amplifier front end; an optical angular multiplexer to produce 96 encoded optical channels each of 5-nsec duration; a chain of four electron-beam-driven KrF laser amplifiers; automated alignment systems for beam alignment; a decoder to provide for pulse compression of some fraction of the total beam train to be delivered to target, and a target chamber to house and diagnose fusion targets. The front end configuration uses a stable resonator master oscillator to drive an injection-locked unstable resonator slave oscillator. An extension of existing technology has been used to develop an electrooptic switchout at 248 nm that produces a 5-nsec pulse from the longer slave oscillator pulse. This short pulse is amplified by a postamplifier. Using these discharge lasers, the front end then delivers at least 250 mJ of KrF laser light output to the optical encoder

  12. Artificial-recharge investigation near Aurora, Nebraska: 2-year progress report

    Science.gov (United States)

    Lichtler, William F.; Stannard, David I.; Kouma, Edwin

    1979-01-01

    This report presents the results of the first 2 years of a 4-year investigation of potential for artificial recharge and recharge methods that might be used to mitigate excessive aquifer depletion in Nebraska. A Quaternary sand-and-gravel aquifer near Aurora, Nebr., was recharged by injecting water through a well at a rate of approximately 730 gallons per minute for nearly 6 months. Total recharge was 530 acre-feet. Recharge was intermittent during the first 2 months, but was virtually continuous during the last 4 months. Buildup of the water level in the recharge well was 17 feet. The rate of buildup indicates that the well could have accepted water by gravity flow at more than 3,000 gallons per minute for at least 1 year. The cause of a continuing slow rise in water levels in the recharge well in contrast to nearly stable water levels in observation wells as close as 10 feet from the recharge well is as yet uncertain. The recharge water and the native ground water appeared to be chemically compatible. Infiltration rates from 24-foot-diameter surface impoundments ranged from 0.04 to 0.66 feet per day. The higher rates may have resulted in part from leakage down incompletely sealed holes that were drilled to install monitoring equipment. The investigation, including a report on the entire project, is scheduled for completion by 1980.

  13. miR-137 suppresses tumor growth of malignant melanoma by targeting aurora kinase A.

    Science.gov (United States)

    Chang, Xiao; Zhang, Haiping; Lian, Shi; Zhu, Wei

    2016-07-01

    As an oncogene, aurora kinase A (AURKA) is overexpressed in various types of human cancers. However, the expression and roles of AURKA in malignant melanoma are largely unknown. In this study, a miR-137-AURKA axis was revealed to regulate melanoma growth. We found a significant increase in levels of AURKA in melanoma. Both genetic knockdown and pharmacologic inhibition of AURKA decreased tumor cell growth in vitro and in vivo. Further found that miR-137 reduced AURKA expression through interaction with its 3' untranslated region (3'UTR) and that miR-137 was negatively correlated with AURKA expression in melanoma specimens. Overexpression of miR-137 decreased cell proliferation and colony formation in vitro. Notably, re-expression of AURKA significantly rescued miR-137-mediated suppression of cell growth and clonality. In summary, these results reveal that miR-137 functions as a tumor suppressor by targeting AURKA, providing new insights into investigation of therapeutic strategies against malignant melanoma. PMID:27233613

  14. Sunspot turning-points and aurorae since A.D. 1510

    International Nuclear Information System (INIS)

    Dates of solar maxima and minima extending back to c. 1610 were estimated by Wolf and Wolfer at Zuerich (Waldmeier, 1961) in the nineteenth century, and those back to c. 1710 have been generally accepted. Slight modifications have already been suggested by the author (Schove, 1967) for the seventeenth century, although, in that century, even the existence of the eleven-year cycle has been questioned (Eddy, 1976). In the course of any sunspot cycle one finds a pattern of the aurorae in place and time characteristic of sunspot cycles of the particular amplitude-class. These patterns since c. 1710 can be linked to the precise dates of the Zuerich turning-points by a set of empirical rules. A sunspot rule is based on the Gnevyshev gap, the gap in large sunspots near the 'smoothed' maximum. These rules are here applied to the period c. 1510-1710 to give improved determination of earlier turning-points, and approximately confirm the dates given for the seventeenth century by Wolfer and for most of the later sixteenth century by Link (1978). Some turning-points for the fifteenth century and revised sunspot numbers for the period 1700-48 are also given. (Auth.)

  15. Cross-Field Current Instabilities in Thin Ionization Layers and the Enhanced Aurora

    Energy Technology Data Exchange (ETDEWEB)

    Jay R. Johnson and Hideo Okuda

    2008-05-20

    Nearly half of the time, auroral displays exhibit thin, bright layers known as \\enhanced aurora." There is a substantial body of evidence that connects these displays with thin, dense, heavy ion layers in the E-region. Based on the spectral characteristics of the enhanced layers, it is believed that they result when wave-particle interaction heats ambient electrons to energies at or just above the 17 eV ionization energy of N2. While there are several possible instabilities that could produce suprathermal electrons in thin layers, there has been no clear theoretical investigation which examines in detail how wave instabilities in the thin ionization layers could develop and produce the suprathermal electrons. We examine instabilities which would occur in thin, dense, heavy ion layers using extensive analytical analysis combined with particle simulations. We analyze a cross field current instability that is found to be strongly unstable in the heavy ion layers. Electrostatic simulations show that substantial heating of the ambient electrons occurs with energization at or above the N2 ionization energy.

  16. Combined geophysical methods for mapping infiltration pathways at the Aurora Water Aquifer recharge and recovery site

    Science.gov (United States)

    Jasper, Cameron A.

    Although aquifer recharge and recovery systems are a sustainable, decentralized, low cost, and low energy approach for the reclamation, treatment, and storage of post- treatment wastewater, they can suffer from poor infiltration rates and the development of a near-surface clogging layer within infiltration ponds. One such aquifer recharge and recovery system, the Aurora Water site in Colorado, U.S.A, functions at about 25% of its predicted capacity to recharge floodplain deposits by flooding infiltration ponds with post-treatment wastewater extracted from river bank aquifers along the South Platte River. The underwater self-potential method was developed to survey self-potential signals at the ground surface in a flooded infiltration pond for mapping infiltration pathways. A method for using heat as a groundwater tracer within the infiltration pond used an array of in situ high-resolution temperature sensing probes. Both relatively positive and negative underwater self-potential anomalies are consistent with observed recovery well pumping rates and specific discharge estimates from temperature data. Results from electrical resistivity tomography and electromagnetics surveys provide consistent electrical conductivity distributions associated with sediment textures. A lab method was developed for resistivity tests of near-surface sediment samples. Forward numerical modeling synthesizes the geophysical information to best match observed self- potential anomalies and provide permeability distributions, which is important for effective aquifer recharge and recovery system design, and optimization strategy development.

  17. Energetic electron precipitation in the aurora as determined by x-ray imaging

    International Nuclear Information System (INIS)

    This work examines two aspects of energetic-particle dynamics in the Earth's magnetosphere through the use of an x-ray imager flown from a stratospheric balloon in the auroral zone. The design and theory of this instrument is completely described, including the technique of image formation using an on-board microprocessor and a statistical analysis of the imaging process. Day-side energetic-electron precipitation is examined in the context of global energy dissipation during the substorm process. It is found that the relationship between events on the night side and the day side are considerably more complex that can be modeled with just a simple picture of drifting particles that induced instabilities, wave growth, and pitch-angle diffusion into the loss cone. The driving force for precipitation is probably not the presence of the energetic electrons (>30 keV) alone, but is influenced either by local effects or the less energetic component. The presence of small-scale structure, including gradients and complex motions in the precipitation region in the morning sector, suggests a local process influencing the rate of electron precipitation. The spatial and temporal evolution of a classic 5-15 second pulsating aurora during the post-breakup phase is also examined with the x-ray imager

  18. Superthermal Electron Magnetosphere-Ionosphere Coupling in the Diffuse Aurora in the Presence of ECH Waves

    Science.gov (United States)

    Khazanov, G. V.; Tripathi, A. K.; Singhal, R. P.; Himwich, Elizabeth; Glocer, A.; Sibeck, D. G.

    2015-01-01

    There are two main theories for the origin of the diffuse auroral electron precipitation: first, pitch angle scattering by electrostatic electron cyclotron harmonic (ECH) waves, and second, by whistler mode waves. Precipitating electrons initially injected from the plasma sheet to the loss cone via wave-particle interaction processes degrade in the atmosphere toward lower energies and produce secondary electrons via impact ionization of the neutral atmosphere. These secondary electrons can escape back to the magnetosphere, become trapped on closed magnetic field lines, and deposit their energy back to the inner magnetosphere. ECH and whistler mode waves can also move electrons in the opposite direction, from the loss cone into the trap zone, if the source of such electrons exists in conjugate ionospheres located at the same field lines as the trapped magnetospheric electron population. Such a situation exists in the simulation scenario of superthermal electron energy interplay in the region of diffuse aurora presented and discussed by Khazanov et al. (2014) and will be quantified in this paper by taking into account the interaction of secondary electrons with ECH waves.

  19. Simultaneous measurements of X-rays and electrons during a pulsating aurora

    Directory of Open Access Journals (Sweden)

    N. Østgaard

    Full Text Available The PULSAUR II rocket was launched from Andøya Rocket Range at 23.43 UT on 9 February 1994 into a pulsating aurora. In this paper we focus on the observations of precipitating electrons and auroral X-rays. By using models it is possible to deduce the electron energy spectrum from X-ray measurements. Comparisons are made between the deduced electron fluxes and the directly measured electron fluxes on the rocket. We found the shape of the observed and the deduced electron spectra to fit very well, with almost identical e-folding energies in the energy range from 10 ke V to ~60–80 ke V. For the integrated fluxes from 10.8 to 250 ke V, we found a discrepancy of 30% . By combining two models, we have found a good method of deducing the electron precipitation from X-ray measurements. The discrepancies between calculations and measurements are in the range of the uncertainties in the measurements.

    Key words. Ionospheric particle precipitation · Magnetospheric physics · Annual phenomena · Energetic particle

  20. Cross-Field Current Instabilities in Thin Ionization Layers and the Enhanced Aurora

    International Nuclear Information System (INIS)

    Nearly half of the time, auroral displays exhibit thin, bright layers known as 'enhanced aurora'. There is a substantial body of evidence that connects these displays with thin, dense, heavy ion layers in the E-region. Based on the spectral characteristics of the enhanced layers, it is believed that they result when wave-particle interaction heats ambient electrons to energies at or just above the 17 eV ionization energy of N2. While there are several possible instabilities that could produce suprathermal electrons in thin layers, there has been no clear theoretical investigation which examines in detail how wave instabilities in the thin ionization layers could develop and produce the suprathermal electrons. We examine instabilities which would occur in thin, dense, heavy ion layers using extensive analytical analysis combined with particle simulations. We analyze a cross field current instability that is found to be strongly unstable in the heavy ion layers. Electrostatic simulations show that substantial heating of the ambient electrons occurs with energization at or above the N2 ionization energy.

  1. Aurora A kinase expression is increased in leukemia stem cells, and a selective Aurora A kinase inhibitor enhances Ara-C-induced apoptosis in acute myeloid leukemia stem cells

    OpenAIRE

    Kim, Soo-Jeong; Jang, Ji Eun; CHEONG, JUNE-WON; Eom, Ju-In; Jeung, Hoi-Kyung; Kim, Yundeok; Hwang, Doh Yu; Min, Yoo Hong

    2012-01-01

    Background The overexpression of Aurora A kinase (AurA) has been reported in various malignancies, including acute myeloid leukemia (AML). However, the expression of AurA and the effects of AurA inhibition in cancer stem cells are not yet fully understood. We investigated the expression and inhibition of AurA in AML stem cells (CD34+/CD38-). Methods Expression of AurA was investigated in cell lines (NB4 and KG1) that express high levels of CD34 and low levels of CD38. Primary AML cells were h...

  2. Interplanetary magnetic field control of Saturn's polar cusp aurora

    Directory of Open Access Journals (Sweden)

    E. J. Bunce

    2005-06-01

    Full Text Available Dayside UV emissions in Saturn's polar ionosphere have been suggested to be the first observational evidence of the kronian "cusp" (Gérard et al., 2004. The emission has two distinct states. The first is a bright arc-like feature located in the pre-noon sector, and the second is a more diffuse "spot" of aurora which lies poleward of the general location of the main auroral oval, which may be related to different upstream interplanetary magnetic field (IMF orientations. Here we take up the suggestion that these emissions correspond to the cusp. However, direct precipitation of electrons in the cusp regions is not capable of producing significant UV aurora. We have therefore investigated the possibility that the observed UV emissions are associated with reconnection occurring at the dayside magnetopause, possibly pulsed, akin to flux transfer events seen at the Earth. We devise a conceptual model of pulsed reconnection at the low-latitude dayside magnetopause for the case of northwards IMF which will give rise to pulsed twin-vortical flows in the magnetosphere and ionosphere in the vicinity of the open-closed field-line boundary, and hence to bi-polar field-aligned currents centred in the vortical flows. During intervals of high-latitude lobe reconnection for southward IMF, we also expect to have pulsed twin-vortical flows and corresponding bi-polar field-aligned currents. The vortical flows in this case, however, are displaced poleward of the open-closed field line boundary, and are reversed in sense, such that the field-aligned currents are also reversed. For both cases of northward and southward IMF we have also for the first time included the effects associated with the IMF By effect. We also include the modulation introduced by the structured nature of the solar wind and IMF at Saturn's orbit by developing "slow" and "fast" flow models corresponding to intermediate and high strength IMF respectively. We then

  3. Global MHD modeling of ionospheric convection and field-aligned currents associated with IMF By triggered theta auroras

    Science.gov (United States)

    Watanabe, Masakazu; Sakito, Shintaro; Tanaka, Takashi; Shinagawa, Hiroyuki; Murata, Ken T.

    2014-08-01

    Using numerical magnetohydrodynamic simulations, we investigate the evolution of ionospheric convection and field-aligned currents (FACs) when θ auroras are formed in response to interplanetary magnetic field (IMF) By transitions. When the polarity of IMF By switches abruptly during northward IMF periods, the crossbar of the θ aurora is isolated from the flankside auroral oval and drifts into the polar cap. This drift motion is involved in a large round cell associated with new IMF By, with sunward convection residing only on the dayside tip of the crossbar. There exists an IMF By-controlled large-scale FAC system on the crossbar. When the θ aurora is drifting duskward (dawnward), the FACs are located on the dawnside (duskside) boundary of the crossbar adjacent to the "new" lobe. In contrast, the magnetospheric source region of the crossbar FAC system is located on the duskside (dawnside) boundary of the protruded plasma sheet adjacent to the "old" lobe. In the source region, plasma thermal pressure feeds the electromagnetic energy of FACs, and these processes can be interpreted as coupling of slow mode and Alfvén mode disturbances. In the ionosphere, the crossbar-associated FACs close with part of the region 1 currents associated with the new crescent cell. The magnetospheric source of that part of the region 1 FACs is located on the plasma sheet boundary and the magnetopause both adjacent to the new lobe. Dynamo processes in the old-lobe side and the new-lobe side work together to drive the ionospheric drift motion of the crossbar.

  4. Evolution of the current system during solar wind pressure pulses based on aurora and magnetometer observations

    Science.gov (United States)

    Nishimura, Yukitoshi; Kikuchi, Takashi; Ebihara, Yusuke; Yoshikawa, Akimasa; Imajo, Shun; Li, Wen; Utada, Hisashi

    2016-08-01

    We investigated evolution of ionospheric currents during sudden commencements using a ground magnetometer network in conjunction with an all-sky imager, which has the advantage of locating field-aligned currents much more accurately than ground magnetometers. Preliminary (PI) and main (MI) impulse currents showed two-cell patterns propagating antisunward, particularly during a southward interplanetary magnetic field (IMF). Although this overall pattern is consistent with the Araki (solar wind sources of magnetospheric ultra-low-frequency waves. Geophysical monograph series, vol 81. AGU, Washington, DC, pp 183-200, 1994. doi: 10.1029/GM081p0183) model, we found several interesting features. The PI and MI currents in some events were highly asymmetric with respect to the noon-midnight meridian; the post-noon sector did not show any notable PI signal, but only had an MI starting earlier than the pre-noon MI. Not only equivalent currents but also aurora and equatorial magnetometer data supported the much weaker PI response. We suggest that interplanetary shocks impacting away from the subsolar point caused the asymmetric current pattern. Additionally, even when PI currents form in both pre- and post-noon sectors, they can initiate and disappear at different timings. The PI currents did not immediately disappear but coexisted with the MI currents for the first few minutes of the MI. During a southward IMF, the MI currents formed equatorward of a preexisting DP-2, indicating that the MI currents are a separate structure from a preexisting DP-2. In contrast, the MI currents under a northward IMF were essentially an intensification of a preexisting DP-2. The magnetometer and imager combination has been shown to be a powerful means for tracing evolution of ionospheric currents, and we showed various types of ionospheric responses under different upstream conditions.

  5. Can the downward current region of the aurora be simulated in the laboratory?

    Science.gov (United States)

    Gunell, H.; Andersson, L.; De Keyser, J.; Mann, I.

    2016-05-01

    A laboratory plasma device is proposed to simulate the downward current region of the aurora. In this device, a discharge in neon is used as a plasma source to represent the hot plasma of the magnetosphere, and a sodium Q-machine source represents the ionospheric plasma. An electrostatic Vlasov model is used to simulate both the downward current region itself and the proposed laboratory analogue. All important phenomena that appear in the simulation of space are found in the laboratory simulation too: a double layer carries most of the potential difference; double layers are in constant motion in the direction of decreasing magnetic field; electron phase space holes appear on the high potential side of double layers and these holes carry a part of the potential difference during double layer disruptions. The ability to simulate auroral physics in the laboratory is better for the downward than the upward current region, because of the lower levels of ion acoustic-like waves in the laboratory model of the former region. Better laboratory-space agreement is found when the discharge and Q-machine ions are of similar masses. If the masses differ significantly, as they do when using helium together with sodium ions, waves on the ion time scale dominate the plasma on the low potential side of the double layer, and there is a tendency toward multiple double layers appearing simultaneously at different locations. The experiment is suitable for the study of heating processes that occur in the downward current region and to address the behaviour of the current–voltage relationship for low voltages.

  6. A comparison of optical and coherent HF radar backscatter observations of a post-midnight aurora

    Directory of Open Access Journals (Sweden)

    S. E. Milan

    Full Text Available A poleward-progressing 630 nm optical feature is observed between approximately 0100 UT and 0230 UT (0400 MLT to 0530 MLT by a meridian-scanning photometer (MSP located at Ny Ålesund, Svalbard. Simultaneous coherent HF radar measurements indicate a region of poleward-expanding backscatter with rapid sunward plasma flow velocity along the MSP meridian. Spatial maps of the backscatter indicate a stationary backscatter feature aligned obliquely with respect to the MSP meridian, which produces an impression of poleward-expansion as the MSP progresses to later MLT. Two interpretations of the observations are possible, depending on whether the arc system is considered to move (time-dependent or to be stationary in time and apparent motion is produced as the MSP meridian rotates underneath it (time-independent. The first interpretation is as a poleward motion of an east-west aligned auroral arc. In this case the appearance of the region of backscatter is not associated with the optical feature, though the velocities within it are enhanced when the two are co-located. The second interpretation is as a polar arc or theta aurora, common features of the polar cap under the prevailing IMF northwards conditions. In this case the backscatter appears as an approximately 150 km wide region adjacent to the optical arc. In both interpretations the luminosity of the optical feature appears related to the magnitude of the plasma flow velocity. The optical features presented here do not generate appreciable HF coherent backscatter, and are only identifiable in the backscatter data as a modification of the flow by the arc electrodynamics.

  7. 16-Hydroxycleroda-3,13-dien-15,16-olide deregulates PI3K and Aurora B activities that involve in cancer cell apoptosis

    International Nuclear Information System (INIS)

    Highlights: → Natural product PL3 induced cancer cell apoptosis and cell cycle arrest. → PL3 targeted and de-regulated PI3K pathway activities. → De-activated PI3K pathway caused Aurora B degradation and spindle dysfunction. → PL3 could reverse the drug-resistance of Bcr-ABL T315I-positive cells to Imatinib. -- Abstract: The PI3K-AKT pathway and Aurora kinase play essential roles in such cellular processes as cell survival, angiogenesis, and differentiation, and are usually expressed at maximum levels during cancer cell proliferation. The present study investigated the effect of the natural compound, 16-hydroxycleroda-3,13-dien-15,16-olide (PL3), on regulating the PI3K-AKT pathway and Aurora B, which led to cancer cell apoptosis. PL3 acts as a PI3K inhibitor by influencing cell survival, signaling transduction, and cell cycle progression. It was observed that PL3 targeted and induced dephosphorylation of the PI3K pathway, degradation of Aurora B and mitotic-related gene expressions, and sequentially shut down the cell cycle. This eventually resulted in cell death. As Aurora B was downregulated, spindle dysfunction and destruction of the G2/M phase checkpoint resulted in DNA-damaged cells undergoing apoptosis. Moreover, PL3 also resensitized T315I-mutated Bcr-ABL+ BA/F3 cells to improve the cytotoxicity of Imatinib in Imatinib-resistant cell line. Taken together, PL3 can perturb the PI3K-AKT pathway and Aurora B resulting in gene silencing and cell cycle disturbance. It was demonstrated that PL3 acted like a novel small-molecule PI3K modulator, thereby potentially contributing to cancer chemotherapy and combination medication.

  8. Relationship of increased aurora kinase A gene copy number, prognosis and response to chemotherapy in patients with metastatic colorectal cancer

    OpenAIRE

    Dotan, E; Meropol, N J; Zhu, F; Zambito, F; Bove, B; Cai, K Q; Godwin, A. K.; Golemis, E A; Astsaturov, I; Cohen, S. J.

    2012-01-01

    Background: Increased Aurora kinase A gene copy number (AURKA-CN) has been reported in metastatic colorectal cancer (mCRC), with unknown relationship to clinical outcome. We correlated increased AURKA-CN in mCRC tumours with KRAS mutation status, overall and progression-free survival (OS, PFS). Methods: Sixty-one mCRC tumours were analysed for AURKA-CN using q-PCR, and KRAS mutation status by direct sequencing. Expression of AURKA protein was analysed by immunohistochemistry. Cox-proportional...

  9. Mps1 and Ipl1/Aurora B Act Sequentially to Correctly Orient Chromosomes on the Meiotic Spindle of Budding Yeast

    OpenAIRE

    Meyer, Régis E; Kim, Seoyoung; Obeso, David; Straight, Paul D.; Winey, Mark; Dawson, Dean S.

    2013-01-01

    The conserved kinases Mps1 and Ipl1/Aurora B are critical for enabling chromosomes to attach to microtubules such that partner chromosomes will be segregated correctly from each other, but the precise roles of these kinases have been unclear. Here, imaging of live yeast cells was performed to elucidate the stages of chromosome-microtubule interactions, and their regulation by Ipl1 and Mps1, through meiosis I. Ipl1 was found to release kinetochore-microtubule (kMT) associations following meiot...

  10. A pathway containing the Ipl1/Aurora protein kinase and the spindle midzone protein Ase1 regulates yeast spindle assembly

    OpenAIRE

    Kotwaliwale, Chitra V.; Frei, Stéphanie Buvelot; Stern, Bodo M.; Biggins, Sue

    2007-01-01

    It is critical to elucidate the pathways that mediate spindle assembly and therefore ensure accurate chromosome segregation during cell division. Our studies of a unique allele of the budding yeast Ipl1/Aurora protein kinase revealed that it is required for centrosome-mediated spindle assembly in the absence of the BimC motor protein Cin8. In addition, we found that the Ase1 spindle midzone-associated protein is required for bipolar spindle assembly. The cin8 ipl1 and cin8 ase1 double mutant ...

  11. Representation of the Indian in Calderón’s «La Aurora en Copacabana»

    Directory of Open Access Journals (Sweden)

    José Elías Gutiérrez Meza

    2014-11-01

    Full Text Available The article analyzes the onomastics of the Indian characters, the portrayal of the Inca Empire of Huáscar and Atahualpa, and the Christianization of Guacolda and Yupangui in Calderón’s La Aurora en Copacabana. Rational and proactive, these two characters realize the illegitimacy of the Inca idolatry and embrace the true religion, long before the formal start of Perú’s christianization. Thus, it is argued that this specific representation of the Indian may have been influenced by the close circles indianos of Miguel de Aguirre, who allegedly patronized this comedy.

  12. Mammography Facilities

    Data.gov (United States)

    U.S. Department of Health & Human Services — The Mammography Facility Database is updated periodically based on information received from the four FDA-approved accreditation bodies: the American College of...

  13. Health Facilities

    Science.gov (United States)

    Health facilities are places that provide health care. They include hospitals, clinics, outpatient care centers, and specialized care centers, such as birthing centers and psychiatric care centers. When you ...

  14. Canyon Facilities

    Data.gov (United States)

    Federal Laboratory Consortium — B Plant, T Plant, U Plant, PUREX, and REDOX (see their links) are the five facilities at Hanford where the original objective was plutonium removal from the uranium...

  15. Collision of comet Shoemaker-Levy 9 with Jupiter observed by the NASA infrared telescope facility

    Science.gov (United States)

    Orton, G.; A'Hearn, M.; Baines, K.; Deming, D.; Dowling, T.; Goguen, J.; Griffith, C.; Hammel, H.; Hoffmann, W.; Hunten, D.; Zahnle, K. (Principal Investigator)

    1995-01-01

    The National Aeronautics and Space Administration (NASA) Infrared Telescope Facility was used to investigate the collision of comet Shoemaker-Levy 9 with Jupiter from 12 July to 7 August 1994. Strong thermal infrared emission lasting several minutes was observed after the impacts of fragments C, G, and R. All impacts warmed the stratosphere and some the troposphere up to several degrees. The abundance of stratospheric ammonia increased by more than 50 times. Impact-related particles extended up to a level where the atmospheric pressure measured several millibars. The north polar near-infrared aurora brightened by nearly a factor of 5 a week after the impacts.

  16. Vida útil de pêssegos 'Aurora 2' armazenados sob atmosfera modificada e refrigeração Shelf-life of peaches 'Aurora 2' stored in modified atmosphere and refrigeration

    Directory of Open Access Journals (Sweden)

    Elisângela Elena Nunes

    2004-12-01

    Full Text Available O objetivo deste trabalho foi avaliar a eficiência da película de fécula de mandioca 3% e de sacos plásticos de polietileno de baixa densidade na conservação da qualidade pós-colheita de pêssegos 'Aurora 2' armazenados sob refrigeração (9 + 1ºC e 90 + 5% UR por 10 dias. O experimento foi realizado no DCA/Ufla, em Lavras-MG. A fécula 3% induziu maior perda de massa, comprometendo a qualidade final do fruto e tendo vida útil de apenas 6 dias. O uso do polietileno reduziu a perda de massa e manteve a firmeza, diminuindo a solubilização das pectinas.The goal of the present work was to evaluate the use of starch film of cassava and polyethylene package in postharvest quality maintenance of peaches 'Aurora 2' stored under refrigeration (9 + 1ºC e 90 + 5% RH for 10 days. This experiment was carried out in DCA/Ufla, Lavras, MG. The film at the concentration of 3% showed higher mass loss and compromising the final quality, with shelf-life only for 6 days. The fruits packed with polyethylene bags presented reduction of mass loss and firmness maintenance due to pectin solubilization decrease.

  17. From the sun's corona to the polar cusp aurora above Svalbard. Interplanetary and terrestrial effects of a coronal transient

    International Nuclear Information System (INIS)

    The report presents a study of the flare-related coronal transient of Nov. 27, 1979, with the resulting interplanetary (IP) shock, and the associated auroral and magnetic effects that were observed from the ground 72 hours after the initial coronal brightening. The observed disturbance of the interplanetary magnetic field (IMF) resulting from the coronal mass ejection is discussed in relation to a model discription of flare-related perturbations of the solar current sheet. The power transfer from the solar wind to the magnetosphere did not rise above the treshold value for magnetospheric strom triggering in this case. thus, the IP shock was not followed by a major storm. However, distinct signatures related to the IP disturbance were observed in the polar cusp aurorae above Svaldbard and in the local magnetic field. The dynamical behaviour of the cusp aurora is discussed in relation to different models of plasma transfer across the dayside magnetopause, from the shocked solar wind to the magnetosphere. A detailed analysis of the available information from interplanetary space and the ground indicates that the main auroral dynamics observed in this case are related to localized, impulsive plasma injections associated with flux transfer events

  18. A shared frequency set between the historical mid-latitude aurora records and the global surface temperature

    CERN Document Server

    Scafetta, Nicola

    2012-01-01

    Herein we show that the historical records of mid-latitude auroras from 1700 to 1966 present oscillations with periods of about 9, 10-11, 20-21, 30 and 60 years. The same frequencies are found in proxy and instrumental global surface temperature records since 1650 and 1850, respectively and in several planetary and solar records. Thus, the aurora records reveal a physical link between climate change and astronomical oscillations. Likely, there exists a modulation of the cosmic ray flux reaching the Earth and/or of the electric properties of the ionosphere. The latter, in turn, have the potentiality of modulating the global cloud cover that ultimately drives the climate oscillations through albedo oscillations. In particular, a quasi 60-year large cycle is quite evident since 1650 in all climate and astronomical records herein studied, which also include an historical record of meteorite fall in China from 619 to 1943. These findings support the thesis that climate oscillations have an astronomical origin. We ...

  19. Long-term Spatial and Temporal Variations of Aurora Borealis Events in the Period 1700--1905

    CERN Document Server

    Vázquez, M; Gallego, M C

    2013-01-01

    Catalogues and other records of aurora-borealis events were used to study the long-term spatial and temporal variation of these phenomena in the period from 1700 to 1905 in the Northern Hemisphere. For this purpose, geographic and geomagnetic coordinates were assigned to approximately 27 000 auroral events with more than 80 000 observations. They were analysed separately in three large-scale areas: i) Europe and North Africa, ii) North America, and iii) Asia. There was a clear need to fill some gaps existing in the records so as to have a reliable proxy of solar activity, especially during the 18th century. In order to enhance the long-term variability, an 11-year smoothing window was applied to the data. Variations in the cumulative numbers of auroral events with latitude (in both geographic and geomagnetic coordinates) were used to discriminate between the two main solar sources: coronal mass ejections and high-speed streams from coronal holes. The characteristics of the associated aurorae correlate differe...

  20. MAVEN Primary Mission Results from the Imaging UltraViolet Spectrograph: Aurora, Meteor Showers, Dayglow and Corona

    Science.gov (United States)

    Schneider, Nicholas

    2016-07-01

    The Imaging Ultraviolet Spectrograph (IUVS) is one of nine science instruments aboard the Mars Atmosphere and Volatile and EvolutioN (MAVEN) spacecraft. Its payload is dedicated to exploring the upper atmosphere of Mars and understanding the magnitude and drivers of Mars' atmospheric escape rate. The instrument is among the most powerful spectrographs sent to another planet, with several key capabilities: (1) separate Far-UV & Mid-UV channels for stray light control, (2) a high resolution echelle mode to resolve deuterium and hydrogen emission, (3) internal instrument pointing and scanning capabilities to allow complete mapping and nearly continuous operation, and (4) optimization for airglow studies. I will present an overview of selected IUVS results, including: • The impact of Comet Siding Spring's tail on Mars' atmosphere; • The discovery of diffuse aurora at Mars, and its contrast with previously detected discrete aurora near crustal fields; • Significant seasonal and short-timescale variability in thermospheric dayglow emissions; • Global ozone maps spanning six months of seasonal evolution; and • Mapping of the Mars H and O coronas, to measure the escape rates of H and O and their variability.

  1. Excitation of O(1D) atoms in aurorae and emission of the forbidden OI 6300-A line

    Science.gov (United States)

    Rees, M. H.; Roble, R. G.

    1986-01-01

    The electron aurora leads to six processes capable of exciting the O(1D2) metastable state of the atomic-oxygen ground-state configuration, the parent state of the 6300-A red line. Altitude profiles of the volume emission rate resulting from each process are computed for Maxwellian electron spectra with characteristic energies between 0.1 and 2.0 keV. Since each process peaks at a different altitude, the sum or total volume emission rate extends over a wide altitude range. Measurements of 6300-A emission obtained by rocket and satellite-borne instruments are summarized, and it is shown that the chemical reaction of N(2D) with O2 is the major source of O(1D) atoms in the electron aurora. New calculations of the 6300-A:4728-A column emission-rate ratio are presented for a range of characteristic energies in an assumed Maxwellian electron spectrum. An approximate equation for the red-line emission per unit energy input is given as a function of electron-spectrum characteristic energy.

  2. Aurora-A mediated histone H3 phosphorylation of threonine 118 controls condensin I and cohesin occupancy in mitosis.

    Science.gov (United States)

    Wike, Candice L; Graves, Hillary K; Hawkins, Reva; Gibson, Matthew D; Ferdinand, Michelle B; Zhang, Tao; Chen, Zhihong; Hudson, Damien F; Ottesen, Jennifer J; Poirier, Michael G; Schumacher, Jill; Tyler, Jessica K

    2016-01-01

    Phosphorylation of histone H3 threonine 118 (H3 T118ph) weakens histone DNA-contacts, disrupting the nucleosome structure. We show that Aurora-A mediated H3 T118ph occurs at pericentromeres and chromosome arms during prophase and is lost upon chromosome alignment. Expression of H3 T118E or H3 T118I (a SIN mutation that bypasses the need for the ATP-dependent nucleosome remodeler SWI/SNF) leads to mitotic problems including defects in spindle attachment, delayed cytokinesis, reduced chromatin packaging, cohesion loss, cohesin and condensin I loss in human cells. In agreement, overexpression of Aurora-A leads to increased H3 T118ph levels, causing cohesion loss, and reduced levels of cohesin and condensin I on chromatin. Normal levels of H3 T118ph are important because it is required for development in fruit flies. We propose that H3 T118ph alters the chromatin structure during specific phases of mitosis to promote timely condensin I and cohesin disassociation, which is essential for effective chromosome segregation. PMID:26878753

  3. Cold storage of peaches cv. Aurora grown in the Zona da Mata Mineira, Minas Gerais State, Brazil

    Directory of Open Access Journals (Sweden)

    Danielle Fabíola Pereira Silva

    2013-12-01

    Full Text Available This study aimed to evaluate the postharvest behavior of peach cv. Aurora 1 harvested in the Zona da Mata region of Minas Gerais in two ripening stages and kept under different storage temperatures. Fruits on mid-ripe and fully ripe stages were stored at three temperatures: 5.6 ± 1.57 °C and 72.8 ± 3.8% RH; 10.4 ± 0.5 °C and 95.8 ± 5.5% RH; 21.04 ± 1.63 °C and 96.9 ± 2.6% RH up to 28 storage days (SD . During storage, fruits stored at 21.04 ± 1.63 °C were evaluated every two days until 8 SD, and every four days for fruits stored at other temperatures. The harvest day was assigned as day zero. The variables evaluated were CO2 production, color of the pericarp and pulp, fresh mass loss, flesh firmness, total soluble solids, titratable acidity, contents of ascorbic acid and carotenoids. The fresh mass loss increased during storage, peaking at 5.6 °C. The reduction in ascorbic acid content was higher in fully ripe fruits at all temperatures. Mid-ripe fruits reached the end of the storage period with better quality. The temperature of 10.4 °C was the most efficient in keeping postharvest quality of peach cv. Aurora 1 harvested in the Zona da Mata region.

  4. Finite-difference time-domain modeling of infrasound from pulsating auroras and comparison with recent experiments

    Science.gov (United States)

    de Larquier, S.; Pasko, V. P.; Stenbaek-Nielsen, H. C.; Wilson, C. R.; Olson, J. V.

    2009-12-01

    Atmospheric infrasonic waves are acoustic waves with frequencies ranging from 0.02 to 10 Hz, slightly higher than the acoustic cut-off frequency (approximately 0.032 Hz), but lower than the audible frequencies (typically 20 Hz-15 kHz) [e.g., Blanc, Ann. Geophys., 3, 673, 1985]. A number of natural events have been identified as generating atmospheric infrasound, such as volcanoes, tornadoes, avalanches, earthquakes [e.g., Bedard and Georges, Physics Today, S3, 32, 2000], ocean surfaces [e.g., Gossard and Hooke, Waves in the Atmosphere, Elsevier, 1975, Ch. 9], lightning [e.g., Assink et al., GRL, 35, L15802, 2008; Pasko, JGR, 114, D08205, 2009], or transient luminous events in the middle atmosphere termed sprites [e.g., Farges, Lightning: Principles, Instruments and Applications, H.D. Betz et al. (eds), Springer, 2009, Ch. 18]. The importance of infrasound studies has been emphasized in the past ten years from the Comprehensive Nuclear-Test-Ban Treaty verification perspective [e.g., Le Pichon et al., JGR, 114, D08112, 2009]. A proper understanding of infrasound propagation in the atmosphere is required for identification and classification of different infrasonic waves and their sources [Drob et al., JGR, 108, D21, 4680, 2003]. The goal of the present work is to provide a quantitative interpretation and explanation of infrasonic signatures from pulsating auroras reported recently by Wilson et al. [GRL, 32, L14810, 2005]. The infrasound signals observed with an infrasonic array at Fairbanks, Alaska had a mean amplitude of 0.05 Pa, a delay of about 5 minutes from the pulsating aurora, and an almost normal incidence on the ground plane [Wilson et al., 2005]. We employ a finite-difference time-domain (FDTD) model of infrasound propagation in a realistic atmosphere. We use the absorption model of infrasound introduced by Sutherland and Bass [J. Acoust. Soc. Am., 115, 1012, 2004]. Classical absorption mechanisms as well as molecular relaxation mechanisms are taken into

  5. netPICOMAG: a low-cost turn-key magnetometer for aurora detection

    Science.gov (United States)

    Schofield, I.; Connors, M.

    2008-12-01

    Previous work on development of a compact, low-cost, fluxgate magnetometer, dubbed PICOMAG, yielded a 1-nanotesla resolution, 1-second cadence instrument, suitable for research or teaching solar/terrestrial physics. With a low-cost magnetic instrument and the wider availability of Internet connectivity in the auroral zone (of Canada for example), the potential exists to fill gaps in spatial coverage that still plague auroral geomagnetic research. Thus, the ability to widely distribute accurate, low cost magnetometers was the motivating factor to develop PICOMAG. NetPICOMAG was developed in the effort to refine PICOMAG into a turn-key magnetometer data collection system that is self contained, simple to install and requires zero-maintenance. Once the unit is placed in the ground and connected to the Internet, it locks onto a GPS time signal and begins to transmit magnetic field measurements back to a central data repository, where it is archived, processed and plotted for public viewing via the World Wide Web. It is envisaged (among many other uses) that science teachers can use real scientific data provided by netPICOMAG in teaching the interactions between the sun and the Earth's magnetic field, manifesting itself in the phenomenon known as the northern lights. As such, netPICOMAG can be aptly described and is being promoted as an aurora detector. The netPICOMAG unit is based around three spatially oriented Speake and Company FGM-3/3h series magnetic field sensors that each emit a pulse stream whose frequency is related to the magnetic field along these three axes, and is nearly linearly related to magnetic field perturbations relevant to auroral studies. The individual pulse frequencies are measured by two PIC18F252 programmable microcontrollers. The measurements are combined with a GPS timestamp from a Garmin GPS 18 LVC GPS receiver, and transmitted as plain text as UDP datagrams by a Rabbit Semiconductor RCM4010 8-bit, networked microcontroller module. The self

  6. Aurora-A regulates MTOCs (centrosome) biogenesis but it does not trigger G2/M transition in mouse oocytes matured in vivo

    Czech Academy of Sciences Publication Activity Database

    Šolc, Petr; Panenková, Gabriela; Baran, Vladimír; Šašková, Adéla; Schultz, R. M.; Motlík, Jan

    Waterville : -, 2009. s. 1-1. [Cell Growth & Proliferation. 05.07.2009-10.07.2009, Waterville] R&D Projects: GA MŠk ME08030 Institutional research plan: CEZ:AV0Z50450515 Keywords : Aurora-A Subject RIV: EB - Genetics ; Molecular Biology

  7. Intertextual Sexual Politics: Illness and Desire in Enrique Gomez Carrillo's "Del amor", "del dolor y del vicio" and Aurora Caceres's "La rosa muerta"

    Science.gov (United States)

    LaGreca, Nancy

    2012-01-01

    This study explores the intertextuality between Aurora Caceres's "La rosa muerta" (1914) and the novel "Del amor, del dolor y del vicio" (1898) by her ex-husband, Enrique Gomez Carrillo. Caceres strategically mentions Gomez Carrillo's novel in "La rosa muerta" to invite a reading of her work in dialogue with his. Both narratives follow the sexual…

  8. Marina Facilities

    OpenAIRE

    2014-01-01

    The CIRPAS main facility and headquarters are at Marina Municipal Airport (formerly Fritchie Field, Fort Ord) in Marina, California. CIRPAS has a 30,000 sq. ft. maintenance hanger there, which houses staff offices, an instrument and calibration laboratory, maintenance and payload integration shops, conference rooms, and flight planning and operations control center.

  9. Métodos de propagação do porta-enxerto 'Okinawa' e espaçamentos: efeitos no diâmetro do tronco, fenologia e produção de gemas em pessegueiros 'Aurora-1' Propagation methods of the'Okinawa' rootstock and spacing: effects on the trunck diameter, phenology and bud production in 'Aurora-1' peach trees

    Directory of Open Access Journals (Sweden)

    Newton Alex Mayer

    2008-06-01

    Full Text Available O presente trabalho teve por objetivo estudar o diâmetro do tronco, a fenologia e a produção de gemas em pessegueiros 'Aurora-1', enxertados no porta-enxerto 'Okinawa' propagado por sementes e por estacas herbáceas, em três espaçamentos (6 x 2 m, 6 x 3 m e 6 x 4 m. No 2º e 3º anos após o plantio das mudas (2005 e 2006, respectivamente, foram estudadas 13 variáveis na cultivar-copa 'Aurora-1', além de sete avaliações trimestrais de diâmetro do tronco, mensuradas a 5 cm acima e abaixo do ponto de enxertia. Nas condições experimentais adotadas, conclui-se que: a o diâmetro do tronco de pessegueiros 'Aurora-1' não é influenciado pelo método de propagação do porta-enxerto 'Okinawa' nem pelos diferentes espaçamentos entre plantas; b não há diferença de diâmetro do tronco entre as medições feitas acima e abaixo do ponto de enxertia e não foram constatados sintomas visíveis de incompatibilidade com a cultivar-copa 'Aurora-1', em ambas as formas de propagação do porta-enxerto; c os métodos de propagação do porta-enxerto 'Okinawa' estudados não exercem nenhum efeito diferenciado na fenologia, no comprimento de ramos mistos, na produção de gemas floríferas e vegetativas e em sua relação, avaliadas na cv. Aurora-1; d os diferentes espaçamentos estudados não influenciaram na fenologia, no comprimento de ramos mistos e no número de gemas floríferas por ramo da cv. Aurora-1.The present research had the objective of studying the trunk diameter, the phenology and the bud production in 'Aurora-1' peach trees, budded on 'Okinawa' rootstock propagated by seeds and herbaceous cuttings, in three spacings (6 x 2 m, 6 x 3 m and 6 x 4 m. In 2nd and 3rd year after the planting seedlings (2005 and 2006, respectively, 13 variables were studied related to phenology and bud production in 'Aurora-1' peach tree, beyond seven quarterly diameter trunk evaluations, measured 5 cm above and below of bud point. In the adopted

  10. Inhibiting the Aurora B Kinase Potently Suppresses Repopulation During Fractionated Irradiation of Human Lung Cancer Cell Lines

    Energy Technology Data Exchange (ETDEWEB)

    Sak, Ali, E-mail: ali.sak@uni-due.de [Department of Radiotherapy, West German Cancer Centre (WTZ), University Hospital Essen, University Duisburg-Essen, Essen (Germany); Stuschke, Martin; Groneberg, Michael; Kuebler, Dennis; Poettgen, Christoph [Department of Radiotherapy, West German Cancer Centre (WTZ), University Hospital Essen, University Duisburg-Essen, Essen (Germany); Eberhardt, Wilfried E.E. [Department of Medicine (Cancer Research), West German Cancer Centre (WTZ), University Hospital Essen, University Duisburg-Essen, Essen (Germany)

    2012-10-01

    Purpose: The use of molecular-targeted agents during radiotherapy of non-small-cell lung cancer (NSCLC) is a promising strategy to inhibit repopulation, thereby improving therapeutic outcome. We assessed the combined effectiveness of inhibiting Aurora B kinase and irradiation on human NSCLC cell lines in vitro. Methods and Materials: NSCLC cell lines were exposed to concentrations of AZD1152-hydroxyquinazoline pyrazol anilide (AZD1152-HQPA) inhibiting colony formation by 50% (IC50{sub clone}) in combination with single dose irradiation or different fractionation schedules using multiple 2-Gy fractions per day up to total doses of 4-40 Gy. The total irradiation dose required to control growth of 50% of the plaque monolayers (TCD50) was determined. Apoptosis, G2/M progression, and polyploidization were also analyzed. Results: TCD50 values after single dose irradiation were similar for the H460 and H661 cell lines with 11.4 {+-} 0.2 Gy and 10.7 {+-} 0.3 Gy, respectively. Fractionated irradiation using 3 Multiplication-Sign 2 Gy/day, 2 Multiplication-Sign 2 Gy/day, and 1 Multiplication-Sign 2 Gy/day schedules significantly increased TCD50 values for both cell lines grown as plaque monolayers with increasing radiation treatment time. This could be explained by a repopulation effect per day that counteracts 75 {+-} 8% and 27 {+-} 6% of the effect of a 2-Gy fraction in H460 and H661 cells, respectively. AZD1152-HQPA treatment concomitant to radiotherapy significantly decreased the daily repopulation effect (H460: 28 {+-} 5%, H661: 10 {+-} 4% of a 2-Gy fraction per day). Treatment with IC50{sub clone} AZD1152-HPQA did not induce apoptosis, prolong radiation-induced G2 arrest, or delay cell cycle progression before the spindle check point. However, polyploidization was detected, especially in cell lines without functional p53. Conclusions: Inhibition of Aurora B kinase with low AZD1152-HQPA concentrations during irradiation of NSCLC cell lines affects repopulation during

  11. Inhibiting the Aurora B Kinase Potently Suppresses Repopulation During Fractionated Irradiation of Human Lung Cancer Cell Lines

    International Nuclear Information System (INIS)

    Purpose: The use of molecular-targeted agents during radiotherapy of non-small-cell lung cancer (NSCLC) is a promising strategy to inhibit repopulation, thereby improving therapeutic outcome. We assessed the combined effectiveness of inhibiting Aurora B kinase and irradiation on human NSCLC cell lines in vitro. Methods and Materials: NSCLC cell lines were exposed to concentrations of AZD1152-hydroxyquinazoline pyrazol anilide (AZD1152-HQPA) inhibiting colony formation by 50% (IC50clone) in combination with single dose irradiation or different fractionation schedules using multiple 2-Gy fractions per day up to total doses of 4–40 Gy. The total irradiation dose required to control growth of 50% of the plaque monolayers (TCD50) was determined. Apoptosis, G2/M progression, and polyploidization were also analyzed. Results: TCD50 values after single dose irradiation were similar for the H460 and H661 cell lines with 11.4 ± 0.2 Gy and 10.7 ± 0.3 Gy, respectively. Fractionated irradiation using 3 × 2 Gy/day, 2 × 2 Gy/day, and 1 × 2 Gy/day schedules significantly increased TCD50 values for both cell lines grown as plaque monolayers with increasing radiation treatment time. This could be explained by a repopulation effect per day that counteracts 75 ± 8% and 27 ± 6% of the effect of a 2-Gy fraction in H460 and H661 cells, respectively. AZD1152-HQPA treatment concomitant to radiotherapy significantly decreased the daily repopulation effect (H460: 28 ± 5%, H661: 10 ± 4% of a 2-Gy fraction per day). Treatment with IC50clone AZD1152-HPQA did not induce apoptosis, prolong radiation-induced G2 arrest, or delay cell cycle progression before the spindle check point. However, polyploidization was detected, especially in cell lines without functional p53. Conclusions: Inhibition of Aurora B kinase with low AZD1152-HQPA concentrations during irradiation of NSCLC cell lines affects repopulation during radiotherapy. Thus, concomitant Aurora B kinase inhibition and irradiation

  12. GEOScan: A GEOScience Facility From Space

    Science.gov (United States)

    Dyrud, L. P.; Fentzke, J. T.; Anderson, B. J.; Bishop, R. L.; Bust, G. S.; Cahoy, K.; Erlandson, R. E.; Fish, C. S.; Gunter, B. C.; Hall, F. G.; Hilker, T.; Lorentz, S. R.; Mazur, J. E.; Murphy, S. D.; Mustard, J. F.; O'Brien, P. P.; Slagowski, S.; Trenberth, K. E.; Wiscombe, W. J.

    2012-12-01

    GEOScan is a proposed globally networked orbiting facility that will provide revolutionary, massively dense global geosciences observations. Major scientific research projects are typically conducted using two approaches: community facilities, or investigator led focused missions. GEOScan is a new concept in space science, blending the PI mission and community facility models: it is PI-led, but it carries sensors that are the result of a grass-roots competition, and, uniquely, it preserves open slots for sensors which are purposely not yet decided. The goal is threefold: first, to select sensors that maximize science value for the greatest number of scientific disciplines, second, to target science questions that cannot be answered without simultaneous global space-based measurements, and third to reap the cost advantages of scale manufacturing for space instrumentation. The relatively small size, mass, and power requirements of the GEOScan sensor suite would make it an ideal hosted payload aboard a global constellation of communication satellites, such as Iridium NEXT's 66-satellite constellation or as hosted small-sat payload. Each GEOScan sensor suite consists of 6 instruments: a Radiometer to measure Earth's total outgoing radiation; a GPS Compact Total Electron Content Sensor to image Earth's plasma environment and gravity field; a MicroCam Multispectral Imager to provide the first uniform, instantaneous image of Earth and measure global cloud cover, vegetation, land use, and bright aurora; a Radiation Belt Mapping System (dosimeter) to measure energetic electron and proton distributions; a Compact Earth Observing Spectrometer to measure aerosol-atmospheric composition and vegetation; and MEMS Accelerometers to deduce non-conservative forces aiding gravity and neutral drag studies. These instruments, employed in a constellation, can provide major breakthroughs in Earth and Geospace science, as well as offering a low-cost technology demonstration for

  13. Produtividade de pessegueiros 'Aurora-1' em diferentes espaçamentos e métodos de propagação do porta-enxerto 'Okinawa' Productivity of 'Aurora-1' peach trees as affected by spacing and propagation methods of 'Okinawa' rootstock

    Directory of Open Access Journals (Sweden)

    Newton Alex Mayer

    2012-01-01

    Full Text Available O presente trabalho teve por objetivo estudar a influência de diferentes espaçamentos entre plantas (6x2 m, 6x3 m e 6x4 m e de métodos de propagação do porta-enxerto 'Okinawa' (sementes e estacas herbáceas em variáveis relativas à produção da cultivar Aurora-1 de pessegueiro. O experimento foi desenvolvido em condições de campo, no município de Vista Alegre do Alto (SP, adotando-se as tecnologias recomendadas para a cultura do pessegueiro na região, e as avaliações foram realizadas no segundo e no terceiro ano após o plantio das mudas. Nas condições experimentais adotadas, pode-se concluir que o método de propagação do porta-enxerto 'Okinawa' não interfere em nenhuma das características vegetativas e produtivas da cv. Aurora-1, nas duas safras avaliadas. O espaçamento de 6x2 m promove significativos aumentos na produtividade do pessegueiro 'Aurora-1'.The present research had the objective of studying the influence of different spaces in-row (6x2 m, 6x3 m and 6x4 m and propagation methods of 'Okinawa' rootstock (seeds and herbaceous cuttings in variables related to 'Aurora-1' peach scion production. The trial was carried out at field conditions, in Vista Alegre do Alto, São Paulo State, Brazil, adopting the recommended technologies for peach culture. Evaluations were taken at the 2nd and 3rd years after planting. As conclusions, the propagation methods of 'Okinawa' rootstock did not influence the vegetative and productive characteristics of 'Aurora-1' scion, on both evaluated harvests. The 6x2 m space promotes significant improvements in 'Aurora-1' peach productivity.

  14. Main Facilities

    International Nuclear Information System (INIS)

    This chapter discuss on main nuclear facilities available in the Malaysian Institute for Nuclear Technology Research (MINT). As a national research institute whose core activities are nuclear science and technology, MINT are made up of main commercializable radiation irradiators, pilot plant and fully equipped laboratories. Well elaboration on its characteristics and functions explain for RTP (PUPSPATI TRIGA reactors), Cobalt-60 gamma irradiator, electron beam accelerators, and radioactive waste management center

  15. Nuclear facility

    International Nuclear Information System (INIS)

    In nuclear facilities with a fuel storage pool in a spent fuel pit building there is a filter to each pool through which the fuel pit water is pumped. According to the invention the filter is provided with an independently movable housing placed beneath the surface of the pool water and fixed to the lateral side of the pool by means of detachable fixtures. (orig./RW)

  16. Support facilities

    International Nuclear Information System (INIS)

    Computer support is centered on the Remote Access Data Station (RADS), which is equipped with a 1000 lpm printer, 1000 cpm reader, and a 300 cps paper tape reader with 500-foot spools. The RADS is located in a data preparation room with four 029 key punches (two of which interpret), a storage vault for archival magnetic tapes, card files, and a 30 cps interactive terminal principally used for job inquiry and routing. An adjacent room provides work space for users, with a documentation library and a consultant's office, plus file storage for programs and their documentations. The facility has approximately 2,600 square feet of working laboratory space, and includes two fully equipped photographic darkrooms, sectioning and autoradiographic facilities, six microscope cubicles, and five transmission electron microscopes and one Cambridge scanning electron microscope equipped with an x-ray energy dispersive analytical system. Ancillary specimen preparative equipment includes vacuum evaporators, freeze-drying and freeze-etching equipment, ultramicrotomes, and assorted photographic and light microscopic equipment. The extensive physical plant of the animal facilities includes provisions for holding all species of laboratory animals under controlled conditions of temperature, humidity, and lighting. More than forty rooms are available for studies of the smaller species. These have a potential capacity of more than 75,000 mice, or smaller numbers of larger species and those requiring special housing arrangements. There are also six dog kennels to accommodate approximately 750 dogs housed in runs that consist of heated indoor compartments and outdoor exercise areas

  17. Search for double beta decay of $^{116}$Cd with enriched $^{116}$CdWO$_4$ crystal scintillators (Aurora experiment)

    CERN Document Server

    Danevich, F A; Belli, P; Bernabei, R; Cappella, F; Caracciolo, V; Cerulli, R; Chernyak, D M; d'Angelo, S; Incicchitti, A; Kobychev, V V; Konovalov, S I; Laubenstein, M; Mokina, V M; Poda, D V; Polischuk, O G; Shlegel, V N; Tretyak, V I; Umatov, V I

    2016-01-01

    The Aurora experiment to investigate double beta decay of $^{116}$Cd with the help of 1.162 kg cadmium tungstate crystal scintillators enriched in $^{116}$Cd to 82\\% is in progress at the Gran Sasso Underground Laboratory. The half-life of $^{116}$Cd relatively to the two neutrino double beta decay is measured with the highest up-to-date accuracy $T_{1/2}=(2.62\\pm0.14)\\times10^{19}$ yr. The sensitivity of the experiment to the neutrinoless double beta decay of $^{116}$Cd to the ground state of $^{116}$Sn is estimated as $T_{1/2} \\geq 1.9\\times10^{23}$ yr at 90\\% CL, which corresponds to the effective Majorana neutrino mass limit $\\langle m_{\

  18. An overview of Aurora: a multi-kilojoule KrF laser system for inertial confinement fusion

    International Nuclear Information System (INIS)

    Aurora is a short-pulse high-power krypton-fluoride laser system that serves as an end-to-end technology demonstration prototype for large-scale ultraviolet laser systems of interest for short wavelength inertial confinement fusion (ICF) studies. The system is designed to employ optical angular multiplexing and serial amplification by electron-beam-driven KrF laser amplifiers to deliver 248 nm, 5-ns duration multi-kilojoule laser pulses to ICF targets using a beam train of approximately 1 km in length. The goals for the system are discussed and the design features of the major system components: front-end lasers, amplifier train, and the alignment and controls systems are summarised. (author)

  19. Importance of Biologically Active Aurora-like Ultraviolet Emission: Stochastic Irradiation of Earth and Mars by Flares and Explosions

    CERN Document Server

    Smith, D S; Wheeler, J C; Smith, David S.; Scalo, John

    2003-01-01

    (Abridged) We show that sizeable fractions of incident ionizing radiation from stochastic astrophysical sources can be redistributed to biologically and chemically important UV wavelengths, a significant fraction of which can reach the surface. This redistribution is mediated by secondary electrons, resulting from Compton scattering and X-ray photoabsorption, with energies low enough to excite atmospheric molecules and atoms, resulting in a rich aurora-like spectrum. We calculate the fraction of energy redistributed into biologically and chemically important wavelength regions for spectra characteristic of stellar flares and supernovae using a Monte-Carlo transport code written for this problem and then estimate the fraction of this energy that is transmitted from the atmospheric altitudes of redistribution to the surface for a few illustrative cases. Redistributed fractions are found to be of order 1%, even in the presence of an ozone shield. This result implies that planetary organisms will be subject to mu...

  20. Severe and localized GNSS scintillation at the poleward edge of the nightside auroral oval during intense substorm aurora

    CERN Document Server

    van der Meeren, Christer; Lorentzen, Dag A; Rietveld, Michael T; Clausen, Lasse B N

    2016-01-01

    In this paper we study how GPS, GLONASS, and Galileo navigation signals are compromised by strong irregularities causing severe phase scintillation ($\\mathit{\\sigma }_{\\phi }$ > 1) in the nightside high-latitude ionosphere during a substorm on 3 November 2013. Substorm onset and a later intensification coincided with polar cap patches entering the auroral oval to become auroral blobs. Using Global Navigation Satellite Systems (GNSS) receivers and optical data, we show severe scintillation driven by intense auroral emissions in the line of sight between the receiver and the satellites. During substorm expansion, the area of scintillation followed the intense poleward edge of the auroral oval. The intense auroral emissions were colocated with polar cap patches (blobs). The patches did not contain strong irregularities, neither before entering the auroral oval nor after the aurora had faded. Signals from all three GNSS constellations were similarly affected by the irregularities. Furthermore, two receivers space...

  1. Treatment of human pre-B acute lymphoblastic leukemia with the Aurora kinase inhibitor PHA-739358 (Danusertib

    Directory of Open Access Journals (Sweden)

    Fei Fei

    2012-06-01

    Full Text Available Abstract Background Treatment of Philadelphia chromosome-positive acute lymphoblastic leukemias (Ph-positive ALL with clinically approved inhibitors of the Bcr/Abl tyrosine kinase frequently results in the emergence of a leukemic clone carrying the T315I mutation in Bcr/Abl, which confers resistance to these drugs. PHA-739358, an Aurora kinase inhibitor, was reported to inhibit the Bcr/Abl T315I mutant in CML cells but no preclinical studies have examined this in detail in human ALL. Results We compared the sensitivity of human Bcr/Abl T315I, Bcr/Abl wild type and non-Bcr/Abl ALL cells to this drug. PHA-739358 inhibited proliferation and induced apoptosis independently of Bcr/Abl, the T315I mutation, or presence of the tumor suppressor p53, but the degree of effectiveness varied between different ALL samples. Since short-term treatment with a single dose of drug only transiently inhibited proliferation, we tested combination treatments of PHA-739358 with the farnesyltransferase inhibitor Lonafarnib, with vincristine and with dasatinib. All combinations reduced viability and cell numbers compared to treatment with a single drug. Clonogenic assays showed that 25 nM PHA-739358 significantly reduced the colony growth potential of Ph-positive ALL cells, and combined treatment with a second drug abrogated colony growth in this assay. PHA-739358 further effectively blocked Bcr/Abl tyrosine kinase activity and Aurora kinase B in vivo, and mice transplanted with human Bcr/Abl T315I ALL cells treated with a 3x 7-day cycle of PHA-739358 as mono-treatment had significantly longer survival. Conclusions PHA-739358 represents an alternative drug for the treatment of both Ph-positive and negative ALL, although combined treatment with a second drug may be needed to eradicate the leukemic cells.

  2. In vitro evaluation of Aurora kinase inhibitor—VX680—in formulation of PLA-TPGS nanoparticles

    Science.gov (United States)

    Thuy Duong Le, Thi; Thu Ha, Phuong; Hai Yen Tran, Thi; Nguyen, Dac Tu; Nguyen, Hoai Nam; Khanh Bui, Van; Nhung Hoang, My

    2016-06-01

    Polymeric nanoparticles prepared from poly(lactide)-tocopheryl polyethylene glycol succinate (PLA-TPGS) were used as potential drug carries with many advantages to overcome the disadvantages of insoluble anticancer drugs and enhance blood circulation time and tissues. VX680 is an Aurora kinase inhibitor and is also the foremost Aurora kinase inhibitor to be studied in clinical trials. In this study, we aimed to investigate whether VX680-loaded PLA-TPGS nanoparticles (VX680-NPs) are able to effectively increase the toxicity of chemotherapy. Accordingly, we first synthesized VX680-loaded nanoparticles and NP characterizations of morphology, mean size, zeta potential, and encapsulation efficiency were spherical shape, 63 nm, ‑30 mV and 76%, respectively. Then, we investigated the effects on HeLa cells. The cell cytotoxicity was evaluated by the xCELLigence real-time cell analyzer allowing measurement of changes in electrical impedance on the surface of the E-plate. Analysis of nucleus morphology and level of histone H3 phosphorylation was observed by confocal fluorescence scanning microscopy. Cell cycle distribution and apoptosis were analyzed by flow cytometry. Our results showed that VX680-NPs reduced cell viability with IC50 value lower 3.4 times compared to free VX680. Cell proliferation was inhibited by VX680-NPs accompanied by other effects such as high abnormal changes of nucleus, a decrease of phospho-histone H3 at Ser10 level, an increase of polyploid cells and resulted in higher apoptotic cells. These results demonstrated that VX680-NPs had more cytotoxicity than as treated with VX680 alone. Thus, VX680-NPs may be considered as promising drug delivery system for cancer treatment.

  3. Jovian Mid-Infrared Aurora: Retrospective Analysis of Variability and Cassini Flyby Measurements in Preparation for Juno

    Science.gov (United States)

    Kostiuk, Theodor; Hewagama, Tilak; Livengood, Timothy A.; Fast, Kelly E.; Carlson, Ronald; MacDowall, Robert; Jennings, Donald E.; Pitts, Rebecca

    2014-11-01

    With the approaching arrival of the Juno mission at Jupiter it is important to look at the current knowledge of Jovian phenomena that can or cannot be further studied from orbital spacecraft. It is also important to retrospectively investigate previously acquired data using current improved methods and capabilities. The thermal (mid-) infrared aurora from Jupiter’s polar regions has been studied extensively from ground-based observatories as well as by Voyager IRIS and Cassini CIRS during Jupiter flybys. We report on a reexamination and re-analysis of hydrocarbon emission spectra from the polar regions of Jupiter obtained using ground based infrared heterodyne spectroscopy (IRHS) and Cassini CIRS Fourier transform spectroscopy (FTS) during the flyby of Jupiter in 2000-2001. Measurements with IRHS have been made over 30 years, primarily of ethane near 12 micrometer wavelength. IRHS provides fully resolved individual spectral lines whose shape yields unique information on variability of temperature and abundance. CIRS data, at lower spectral resolution, explores extended spatial distributions and covers a broad spectral region that includes auroral response of ethane as well as several other hydrocarbons in the 8-13 micrometer wavelength region (methane, ethylene, and acetylene). These spectra are radiometrically calibrated and can serve as a sensitive thermometer of the Jovian atmosphere. Recently improved analysis techniques show detailed spatial enhancements of the primary hydrocarbons in northern latitudes. Temporal changes of the ethane line emission over three solar cycles and comparison of retrievals from ethane data taken contemporaneously during the Cassini flyby by both techniques will be compared and results discussed. Juno does not have instrumentation in this spectral region and this work provides complementary information and diagnostics for studying Jovian aurora and magnetosphere in a spectral region and altitude range not directly probed by Juno.

  4. Temperature, salinity and other variables collected from discrete sample and profile observations using CTD, bottle and other instruments from the AURORA AUSTRALIS in the Indian Ocean from 1991-09-25 to 1991-10-27 (NODC Accession 0116370)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NODC Accession 0116370 includes chemical, discrete sample, physical and profile data collected from AURORA AUSTRALIS in the Indian Ocean from 1991-09-25 to...

  5. The ion experiment onboard the Interball-Aurora satellite; initial results on velocity-dispersed structures in the cleft and inside the auroral oval

    Directory of Open Access Journals (Sweden)

    J. A. Sauvaud

    Full Text Available The Toulouse ION experiment flown on the Russian Interball-Aurora mission performs simultaneous ion and electron measurements. Two mass spectrometers looking in opposing directions perpendicular to the satellite spin axis, which points toward the sun, measure ions in the mass and energy ranges 1–32 amu and ~0–14 000 eV. Two electron spectrometers also looking in opposing directions perform measurements in the energy range ~10 eV–20 000 eV. The Interball-Aurora spacecraft was launched on 29 August 1996 into a 62.8° inclination orbit with an apogee of ~3 RE. The satellite orbital period is 6 h, so that every four orbits the satellite sweeps about the same region of the auroral zone; the orbit plane drifts around the pole in ~9 months. We present a description of the ION experiment and discuss initial measurements performed in the cusp near noon, in the polar cleft at dusk, and inside the proton aurora at dawn. Ion-dispersed energy structures resulting from time-of-flight effects are observed both in the polar cleft at ~16 hours MLT and in the dawnside proton aurora close to 06 hours MLT. Magnetosheath plasma injections in the polar cleft, which appear as overlapping energy bands in particle energy-time spectrograms, are traced backwards in time using a particle trajectory model using 3D electric and magnetic field models. We found that the cleft ion source is located at distances of the order of 18 RE from the earth at about 19 MLT, i.e., on the flank of the magnetopause. These observations are in agreement with flux transfer events (FTE occurring not only on the front part of the magnetopause but also in a region extending at least to dusk. We also show that, during quiet magnetic conditions, time-of-flight ion dispersions can also be measured inside the dawn proton aurora. A method similar to that used for the cleft is applied to these auroral energy dispersion signatures. Unexpectedly, the ion source is found to be

  6. Facility Management

    OpenAIRE

    Král, David

    2012-01-01

    Tématem bakalářské práce je nalezení cesty ke zvýšení dlouhodobé efektivnosti a prosperity společnosti, která v rámci své podnikatelské činnosti spravuje a udržuje vlastní nemovitosti v centru Brna. Práce vychází z aktuálního stavu facility managementu společnosti a definování jejich silných a slabých stránek. Základem pro návrh efektivního řízení facility managementu je zpracování finanční analýzy společnosti a sledování nákladů včetně jejich optimalizace. Hlavním přínosem mé bakalářské prác...

  7. Pegamento e crescimento inicial de enxertos do pessegueiro 'Aurora-1' em clones de umezeiro (Prunus mume Sieb. et Zucc. e 'Okinawa' [Prunus persica (L. Batsch] propagados por estacas herbáceas Tissue union and initial growth of 'Aurora-1' peach buds on mume clones (Prunus mume Sieb. et Zucc. and 'Okinawa' [Prunus persica (L. Batsch] propagated by herbaceous cuttings

    Directory of Open Access Journals (Sweden)

    Newton Alex Mayer

    2005-04-01

    Full Text Available O presente estudo teve por objetivo avaliar o pegamento e o crescimento inicial de enxertos do pessegueiro 'Aurora-1' em clones de umezeiro (Prunus mume Sieb. et Zucc. e 'Okinawa' [Prunus persica (L. Batsch] propagados por estacas herbáceas. Realizaram-se dois experimentos, adotando-se a enxertia de borbulhia por escudo (março e borbulhia por escudo modificada (julho. Com os resultados obtidos, pode-se concluir que é viável a realização da enxertia do 'Aurora-1' nos Clones 05; 10 e 15 de umezeiro e no 'Okinawa', tanto em março quanto em julho, com as metodologias utilizadas. O 'Okinawa' induz crescimento mais rápido ao enxerto, de forma que o ponto máximo do comprimento é atingido em tempo menor.This study aimed to evaluate the tissue union and initial growth of 'Aurora-1' peach buds on mume clones (Prunus mume Sieb. et Zucc. and 'Okinawa' [Prunus persica (L. Batsch] propagated by herbaceous cuttings. Two experiments were carried out, being adopted the chip budding (March and chip budding modified (July. The results showed that accomplishment of 'Aurora-1' peach bud on mume Clones 05, 10 and 15 and 'Okinawa' is viable, in both periods, with the methodologies used. The 'Okinawa' induces faster growth to the bud and the maximum length point is reached in a short time.

  8. Mitotic phosphorylation of SOX2 mediated by Aurora kinase A is critical for the stem-cell like cell maintenance in PA-1 cells.

    Science.gov (United States)

    Qi, Dandan; Wang, Qianqian; Yu, Min; Lan, Rongfeng; Li, Shuiming; Lu, Fei

    2016-08-01

    Transcription factor SOX2 is multiple phosphorylated. However, the kinase and the timing regulating SOX2 phosphorylation remains poorly understood. Here we reported mitotic phosphorylation of SOX2 by Aurora kinase A (AURKA). AURKA inhibitors (VX680, Aurora kinase Inhibitor I) but not PLK1 inhibitors (BI2536, CBB2001) eliminate the mitotic phosphorylation of SOX2. Consistently, siRNA inhibition of AURKA can eliminate mitotic SOX2 phosphorylation. Ser220 and Ser251 are two sites that identified for mitotic phosphorylation on SOX2. Moreover, SOX2 mutants (S220A and S251A) can promote SOX2 induced OCT4 re-expression in differentiated cells. These findings reveal a novel regulation mechanism of SOX2 phosphorylation mediated by AURKA in mitosis and its function in stem cell pluripotency maintenance in cancer cells. PMID:27249336

  9. Aurora-A regulates MTOCs (centrosome) biogenesis but it does not trigger G2/M transition in mouse oocytes matured in vivo

    Czech Academy of Sciences Publication Activity Database

    Šolc, Petr; Baran, V.; Panenková, Gabriela; Šašková, Adéla; Böhmová, Tereza; Mayer, Alexandra; Schultz, R. M.; Motlík, Jan

    San Juan Island : Friday Harbor Laboratories, 2010. s. 12-12. [Mechanism of Egg Maturation and Fertilization: From Sea to Land: An international symposium at Friday Harbor Laboratories. 10.09.-12.09.2010, San Juan Island] R&D Projects: GA MŠk ME08030 Institutional research plan: CEZ:AV0Z50450515 Keywords : Aurora-A * mouse oocytes * biogenesis Subject RIV: EB - Genetics ; Molecular Biology

  10. Aurora-A regulates MTOCs (centrosome) biogenesis it does not trigger G2/M transition in mouse oocytes matured in vivo

    Czech Academy of Sciences Publication Activity Database

    Šolc, Petr; Baran, Vladimír; Panenková, Gabriela; Šašková, Adéla; Böhmová, Tereza; Mayer, Alexandra; Schultz, R. M.; Motlík, Jan

    Liběchov : Institute of Animal Physiology and Genetics AS CR, v.v ,, 2010. s. 22-22. [Czech‐Japan Joint Symposium for Animal Reproduction. 20.09.-21.09.2010, Liblice] R&D Projects: GA MŠk ME08030 Institutional research plan: CEZ:AV0Z50450515 Keywords : Aurora-A * mouse oocytes * MTOCs Subject RIV: EB - Genetics ; Molecular Biology

  11. LRD-22, a novel dual dithiocarbamatic acid ester, inhibits Aurora-A kinase and induces apoptosis and cell cycle arrest in HepG2 cells

    International Nuclear Information System (INIS)

    In this study we investigated the antitumor activity of the novel dual dithiocarbamatic acid ester LRD-22 in vitro and in vivo. Several cancer cell lines were employed to determine the effect of LRD-22 on cell growth, and the MTT assay showed there was a significant decrease in viable tumor cell numbers in the presence of LRD-22, especially in the HepG2 cell line. Colony formation assay also showed LRD-22 strongly inhibits HepG2 cell growth. Evaluation of the mechanism involved showed that inhibitory effects of LRD-22 on cell growth are due to induction of apoptosis and G2/M arrest. LRD-22 inhibited Aurora-A phosphorylation at Thr288 and subsequently impaired p53 phosphorylation at Ser315 which was associated with the proteasome degradation pathway. Tumor suppressor protein p53 is stabilized by this mechanism and accumulates through inhibition of Aurora-A kinase activity via treatment with LRD-22. In vivo study of HepG2 xenograft in nude mice also shows LRD-22 suppresses tumor growth at a concentration of 5 mg/kg without animals suffering loss of body weight. In conclusion, our results demonstrate LRD-22 acts as an Aurora-A kinase inhibitor to induce apoptosis and inhibit proliferation in HepG2 cells, and should be considered as a promising targeting agent for HCC therapy. - Highlights: • LRD-22 significantly inhibits cancer cell growth, especially in the HepG2 cell line. • The inhibitory effect of LRD-22 is due to induction of apoptosis and cell cycle arrest. • LRD-22 inhibits Aurora-A phosphorylation which results in subsequent impairment of the p53 pathway. • LRD-22 suppresses tumor growth in xenograft mice without body weight loss

  12. LRD-22, a novel dual dithiocarbamatic acid ester, inhibits Aurora-A kinase and induces apoptosis and cell cycle arrest in HepG2 cells

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Huiling; Li, Ridong [State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing (China); Li, Li [Department of Cell Biology, School of Basic Medical Sciences, Peking University, Beijing (China); Ge, Zemei [State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing (China); Zhou, Rouli, E-mail: rlzhou@bjmu.edu.cn [Department of Cell Biology, School of Basic Medical Sciences, Peking University, Beijing (China); Li, Runtao, E-mail: lirt@bjmu.edu.cn [State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing (China)

    2015-02-27

    In this study we investigated the antitumor activity of the novel dual dithiocarbamatic acid ester LRD-22 in vitro and in vivo. Several cancer cell lines were employed to determine the effect of LRD-22 on cell growth, and the MTT assay showed there was a significant decrease in viable tumor cell numbers in the presence of LRD-22, especially in the HepG2 cell line. Colony formation assay also showed LRD-22 strongly inhibits HepG2 cell growth. Evaluation of the mechanism involved showed that inhibitory effects of LRD-22 on cell growth are due to induction of apoptosis and G2/M arrest. LRD-22 inhibited Aurora-A phosphorylation at Thr{sub 288} and subsequently impaired p53 phosphorylation at Ser{sub 315} which was associated with the proteasome degradation pathway. Tumor suppressor protein p53 is stabilized by this mechanism and accumulates through inhibition of Aurora-A kinase activity via treatment with LRD-22. In vivo study of HepG2 xenograft in nude mice also shows LRD-22 suppresses tumor growth at a concentration of 5 mg/kg without animals suffering loss of body weight. In conclusion, our results demonstrate LRD-22 acts as an Aurora-A kinase inhibitor to induce apoptosis and inhibit proliferation in HepG2 cells, and should be considered as a promising targeting agent for HCC therapy. - Highlights: • LRD-22 significantly inhibits cancer cell growth, especially in the HepG2 cell line. • The inhibitory effect of LRD-22 is due to induction of apoptosis and cell cycle arrest. • LRD-22 inhibits Aurora-A phosphorylation which results in subsequent impairment of the p53 pathway. • LRD-22 suppresses tumor growth in xenograft mice without body weight loss.

  13. Temperature-sensitive ipl1-2/Aurora B mutation is suppressed by mutations in TOR complex 1 via the Glc7/PP1 phosphatase

    OpenAIRE

    Tatchell, Kelly; Makrantoni, Vasso; Stark, Michael J. R.; Robinson, Lucy C.

    2011-01-01

    Ipl1/Aurora B is the catalytic subunit of a complex that is required for chromosome segregation and nuclear division. Before anaphase, Ipl1 localizes to kinetochores, where it is required to establish proper kinetochore–microtubule associations and regulate the spindle assembly checkpoint. The protein phosphatase Glc7/PP1 opposes Ipl1 for some of these activities. To more thoroughly characterize the Glc7 phosphatase that opposes Ipl1, we have identified mutations that suppress the thermosensi...

  14. 3D-QSAR and Molecular Docking Studies on Derivatives of MK-0457, GSK1070916 and SNS-314 as Inhibitors against Aurora B Kinase

    Directory of Open Access Journals (Sweden)

    Chunzhi Ai

    2010-11-01

    Full Text Available Development of anticancer drugs targeting Aurora B, an important member of the serine/threonine kinases family, has been extensively focused on in recent years. In this work, by applying an integrated computational method, including comparative molecular field analysis (CoMFA, comparative molecular similarity indices analysis (CoMSIA, homology modeling and molecular docking, we investigated the structural determinants of Aurora B inhibitors based on three different series of derivatives of 108 molecules. The resultant optimum 3D-QSAR models exhibited (q2 = 0.605, r2pred = 0.826, (q2 = 0.52, r2pred = 0.798 and (q2 = 0.582, r2pred = 0.971 for MK-0457, GSK1070916 and SNS-314 classes, respectively, and the 3D contour maps generated from these models were analyzed individually. The contour map analysis for the MK-0457 model revealed the relative importance of steric and electrostatic effects for Aurora B inhibition, whereas, the electronegative groups with hydrogen bond donating capacity showed a great impact on the inhibitory activity for the derivatives of GSK1070916. Additionally, the predictive model of the SNS-314 class revealed the great importance of hydrophobic favorable contour, since hydrophobic favorable substituents added to this region bind to a deep and narrow hydrophobic pocket composed of residues that are hydrophobic in nature and thus enhanced the inhibitory activity. Moreover, based on the docking study, a further comparison of the binding modes was accomplished to identify a set of critical residues that play a key role in stabilizing the drug-target interactions. Overall, the high level of consistency between the 3D contour maps and the topographical features of binding sites led to our identification of several key structural requirements for more potency inhibitors. Taken together, the results will serve as a basis for future drug development of inhibitors against Aurora B kinase for various tumors.

  15. Refined broad-scale sub-glacial morphology of Aurora Subglacial Basin, East Antarctica derived by an ice-dynamics-based interpolation scheme

    OpenAIRE

    Roberts, J. L.; Department of Sustainability, Environment, Water, Population and Communities, Australian Antarctic Division, Hobart, Tasmania, Australia and Antarctic Climate and Ecosystems Cooperative Research Centre, Private Bag 80, Hobart, Tasmania 7001, Australia; Warner, R. C.; Department of Sustainability, Environment, Water, Population and Communities, Australian Antarctic Division, Hobart, Tasmania, Australia and Antarctic Climate and Ecosystems Cooperative Research Centre, Private Bag 80, Hobart, Tasmania 7001, Australia; Young, D.; Institute of Geophysics, Jackson School of Geosciences, University of Texas at Austin, Austin, Texas, USA; Wright, A.; School of GeoSciences, University of Edinburgh Edinburgh, Scotland, UK; van Ommen, T. D.; Department of Sustainability, Environment, Water, Population and Communities, Australian Antarctic Division, Hobart, Tasmania, Australia and Antarctic Climate and Ecosystems Cooperative Research Centre, Private Bag 80, Hobart, Tasmania 7001, Australia; Blankenship, D. D.; Institute of Geophysics, Jackson School of Geosciences, University of Texas at Austin, Austin, Texas, USA; Siegert, M.; School of GeoSciences, Grant Institute, University of Edinburgh, The King's Buildings, West Mains Road, Edinburgh EH9 3JW, UK; Young, N. W.; Department of Sustainability, Environment, Water, Population and Communities, Australian Antarctic Division, Hobart, Tasmania, Australia and Antarctic Climate and Ecosystems Cooperative Research Centre, Private Bag 80, Hobart, Tasmania 7001, Australia; Tabacco, I. E.; Geofisica, Universita di Milano, Milan, Italy; Forieri, A.; Geofisica, Universita di Milano, Milan, Italy; Passerini, A.; Istituto Nazionale di Geofisica e Vulcanologia, Sezione Roma1, Roma, Italia; Zirizzotti, A.; Istituto Nazionale di Geofisica e Vulcanologia, Sezione Roma2, Roma, Italia; Frezzotti, M.; Agenzia nazionale per le nuove tecnologie, l’energia e lo sviluppo economico sostenibile, Rome, Italy

    2011-01-01

    Ice thickness data over much of East Antarctica are sparse and irregularly distributed. This poses difficulties for reconstructing the homogeneous coverage needed to properly assess underlying sub-glacial morphology and fundamental geometric constraints on sea level rise. Here we introduce a new physically-based ice thickness interpolation scheme and apply this to existing ice thickness data in the Aurora Subglacial Basin region. The skill and robustness of the new rec...

  16. Tanshinone I induces human colorectal cancer cell apoptosis: The potential roles of Aurora A-p53 and survivin-mediated signaling pathways.

    Science.gov (United States)

    Lu, Mingjie; Wang, Chen; Wang, Jian

    2016-08-01

    Colorectal cancer (CRC) is one of the most common malignancies worldwide and a leading cause of cancer death. Despite decades of intensive investigations, effective interventional options are still limited and patient prognosis remains poor. Tanshinone I, an active compound from traditional Chinese herbal medicine Salvia miltiorrhiza Bunge, has been shown to inhibit cell growth of leukemia, lung, and breast cancers. However, whether and how Tanshinone I exerts similar effects on CRC needs to be elucidated. Tanshinone I induced CRC cell apoptosis was characterized and the roles of Aurora A-p53 and survivin-mediated pathways were analyzed in different CRC cell lines. Tanshinone I markedly inhibited CRC cell growth and induced apoptosis in CRC cells with functional p53 protein. Interestingly, Tanshinone I did not exert as much inhibitory effect on normal colon epithelial cells or CRC cells with mutant p53, indicating relative selectivity toward colorectal cancer cells with full presence of p53. In tse cells with wild-type p53, data showed that Tanshinone I mediated Aurora A inhibition results in p53 upregulation, which is required for cell apoptosis. In CRC cells with mutant p53 protein (not able to localize to the nucleus), however, Aurora A knockdown failed to induce CRC cell apoptosis. Instead, data showed that protein level of survivin decreased following Tanshinone I treatment. These observations were further substantiated by the pivotal role of survivin in Tanshinone I mediated apoptosis in CRC cells with p53 mutant. Tanshinone I, a novel natural compound, exerts significant inhibitory effect on CRC cell growth via a mechanism involving either Aurora A-p53 axis or survivin-involving mechanism depending on different intrinsic characteristics of tumor cells. PMID:27279458

  17. Phase I study of the selective Aurora A kinase inhibitor MLN8054 in patients with advanced solid tumors: safety, pharmacokinetics, and pharmacodynamics.

    Science.gov (United States)

    Macarulla, Teresa; Cervantes, Andres; Elez, Elena; Rodríguez-Braun, Edith; Baselga, José; Roselló, Susana; Sala, Gemma; Blasco, Inma; Danaee, Hadi; Lee, Yih; Ecsedy, Jeffrey; Shinde, Vaishali; Chakravarty, Arijit; Bowman, Douglas; Liu, Hua; Eton, Omar; Fingert, Howard; Tabernero, Josep

    2010-10-01

    This phase I trial examined the safety, pharmacokinetics, and pharmacodynamics of MLN8054, an oral, selective, small-molecule inhibitor of Aurora A kinase. Patients with advanced solid tumors received increasing doses of MLN8054 in 28-day cycles until dose-limiting toxicity (DLT) was seen in ≥2 of 3-6 patients in a cohort. For the 10-mg and 20-mg cohorts, treatment was administered once daily on days 1 to 5 and 8 to 12. Patients in later cohorts (25, 35, 45, 55, 60, 70, and 80 mg/day) were treated four times daily on days 1 to 14, with the largest dose at bedtime (QID-14D) to mitigate benzodiazepine-like effects possibly associated with peak plasma concentrations. Patients (n = 43) received a median of 1 cycle (range, 1-10). DLT of somnolence was first noted in the 20-mg cohort. Two DLTs of somnolence (n = 1) and transaminitis (n = 1) were seen at QID-14D 80 mg. Grade 2 oral mucositis (n = 1), predicted to be a mechanistic effect, was observed only at QID-14D 80 mg. MLN8054 exposure levels were roughly linear with dose; terminal half-life was 30 to 40 hours. Pharmacodynamic analyses of skin and tumor mitotic indices, mitotic cell chromosome alignment, and spindle bipolarity provided evidence of Aurora A inhibition. MLN8054 dosing for 10 to 14 days in 28-day cycles was feasible. Somnolence and transaminitis were DLTs. Pharmacodynamic analyses in mitotic cells of both skin and tumor provided proof of mechanism for Aurora A kinase inhibition. A more potent, selective, second-generation Aurora A kinase inhibitor, MLN8237, is in clinical development. PMID:20724522

  18. Produtividade de pessegueiros 'Aurora-1' em diferentes espaçamentos e métodos de propagação do porta-enxerto 'Okinawa'

    Directory of Open Access Journals (Sweden)

    Newton Alex Mayer

    2012-01-01

    Full Text Available O presente trabalho teve por objetivo estudar a influência de diferentes espaçamentos entre plantas (6x2 m, 6x3 m e 6x4 m e de métodos de propagação do porta-enxerto 'Okinawa' (sementes e estacas herbáceas em variáveis relativas à produção da cultivar Aurora-1 de pessegueiro. O experimento foi desenvolvido em condições de campo, no município de Vista Alegre do Alto (SP, adotando-se as tecnologias recomendadas para a cultura do pessegueiro na região, e as avaliações foram realizadas no segundo e no terceiro ano após o plantio das mudas. Nas condições experimentais adotadas, pode-se concluir que o método de propagação do porta-enxerto 'Okinawa' não interfere em nenhuma das características vegetativas e produtivas da cv. Aurora-1, nas duas safras avaliadas. O espaçamento de 6x2 m promove significativos aumentos na produtividade do pessegueiro 'Aurora-1'.

  19. Temperature, salinity and other variables collected from underway - surface observations using PAR Sensor and other instruments from the AURORA AUSTRALIS, DISCOVERER and others in the Bering Sea, Caribbean Sea and others from 1994-01-28 to 2004-07-02 (NODC Accession 0109923)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NODC Accession 0109923 includes biological, chemical, meteorological, physical and underway - surface data collected from AURORA AUSTRALIS, DISCOVERER, NATHANIEL B....

  20. QM/MD studies of the dynamics of the MTSL spin label in Aurora-A kinase protein activation loop

    CERN Document Server

    Concilio, Maria Grazia; Bayliss, Richard; Burgess, Selena

    2015-01-01

    Molecular dynamics(MD)simulations using a graphics processing unit (GPU) has been employed in order to determine the conformational space of the methane-thiosulfonate spin label (MTSL) attached to the activation loop of the Aurora-A kinase protein and compared with quantum mechanical (QM) methods rooted on density functional theory (DFT). MD provided a wealth of information about interactions between the MTSL and the residues of the protein and on the different motional contributions to the overall dynamics of the MTSL. Data obtained from MD were seen to be in good agreement with those obtained from QM but the dynamics of the system revealed more interactions than those observed from QM methods. A strong correlation between the tumbling of the protein and the transitions of the X4 and X5 dihedral angles of the MTSL, was observed with a consequent effect also the distribution of the nitroxide(NO)group in the space. Theoretical EPR spectra calculated from opportunely selected MD frames showing interactions betw...

  1. Aurora kinase inhibitors attached to iron oxide nanoparticles enhances inhibition of the growth of liver cancer cells

    International Nuclear Information System (INIS)

    We have developed a novel Aurora kinase inhibitor (AKI) AM-005, an analogue of pan-AKI AT-9283. To improve the intracellular efficacy of AM-005 and AT-9283, we utilized magnetite nanoparticles (NPs) to deliver AM-005 and AT-9283 into human SMMC-7721 and HepG2 liver cancer cells. The drug-loaded NPs were prepared through quasi-emulsion solvent diffusion of magnetite NPs with AM-005 or AT-9283. The encapsulated drugs were readily released from NPs, preferentially at low pHs. Upon exposure, cancer cells effectively internalized drug-loaded NPs into lysosome-like vesicles, which triggered a series of cellular changes, including the formation of enlarged cytoplasm, the significant increase of membrane permeability, and the generation of reactive oxygen species (ROS). The increased ROS synthesis sustained over 72 h, whereas that in the cells treated with free-form drugs declined rapidly after 48 h. However, chemical sequestration of the iron core of NPs had a minor influence on the generation of intracellular ROS. On the other hand, uncoupling of AM-005 uptake with NP internalization into cells failed to induce ROS synthesis. Overall, our approach achieved two-fold increase in suppressing the viability of tumor cells in vitro and the growth of tumors in vivo. We conclude that magnetite NPs can be used as pH responsive nanocarriers that are able to improve the efficacy of AKIs

  2. Protein tyrosine phosphatase receptor delta acts as a neuroblastoma tumor suppressor by destabilizing the aurora kinase a oncogene

    LENUS (Irish Health Repository)

    Meehan, Maria

    2012-02-05

    Abstract Background Protein tyrosine phosphatase receptor delta (PTPRD) is a member of a large family of protein tyrosine phosphatases which negatively regulate tyrosine phosphorylation. Neuroblastoma is a major childhood cancer arising from precursor cells of the sympathetic nervous system which is known to acquire deletions and alterations in the expression patterns of PTPRD, indicating a potential tumor suppressor function for this gene. The molecular mechanism, however, by which PTPRD renders a tumor suppressor effect in neuroblastoma is unknown. Results As a molecular mechanism, we demonstrate that PTPRD interacts with aurora kinase A (AURKA), an oncogenic protein that is over-expressed in multiple forms of cancer, including neuroblastoma. Ectopic up-regulation of PTPRD in neuroblastoma dephosphorylates tyrosine residues in AURKA resulting in a destabilization of this protein culminating in interfering with one of AURKA\\'s primary functions in neuroblastoma, the stabilization of MYCN protein, the gene of which is amplified in approximately 25 to 30% of high risk neuroblastoma. Conclusions PTPRD has a tumor suppressor function in neuroblastoma through AURKA dephosphorylation and destabilization and a downstream destabilization of MYCN protein, representing a novel mechanism for the function of PTPRD in neuroblastoma.

  3. Aurora kinase inhibitors attached to iron oxide nanoparticles enhances inhibition of the growth of liver cancer cells

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Xiquan [Southeast University, State Key Laboratory of Bioelectronics and Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Science & Medical Engineering (China); Xie, Li [Southeast University, Zhongda Hospital, School of Medicine (China); Zheng, Ming; Yao, Juan [Jiangsu Chai Tai Tianqing Pharmaceutical Co. Ltd. (China); Song, Lina [Southeast University, State Key Laboratory of Bioelectronics and Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Science & Medical Engineering (China); Chang, Weiwei [Jiangsu Chai Tai Tianqing Pharmaceutical Co. Ltd. (China); Zhang, Yu; Ji, Min, E-mail: minji888@hotmail.com; Gu, Ning, E-mail: guning@seu.edu.cn [Southeast University, State Key Laboratory of Bioelectronics and Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Science & Medical Engineering (China); Zhan, Xi, E-mail: zhan01@gmail.com [University of Maryland School of Medicine, The Center of Vascular and Inflammatory Diseases, The Department of Pathology (United States)

    2015-06-15

    We have developed a novel Aurora kinase inhibitor (AKI) AM-005, an analogue of pan-AKI AT-9283. To improve the intracellular efficacy of AM-005 and AT-9283, we utilized magnetite nanoparticles (NPs) to deliver AM-005 and AT-9283 into human SMMC-7721 and HepG2 liver cancer cells. The drug-loaded NPs were prepared through quasi-emulsion solvent diffusion of magnetite NPs with AM-005 or AT-9283. The encapsulated drugs were readily released from NPs, preferentially at low pHs. Upon exposure, cancer cells effectively internalized drug-loaded NPs into lysosome-like vesicles, which triggered a series of cellular changes, including the formation of enlarged cytoplasm, the significant increase of membrane permeability, and the generation of reactive oxygen species (ROS). The increased ROS synthesis sustained over 72 h, whereas that in the cells treated with free-form drugs declined rapidly after 48 h. However, chemical sequestration of the iron core of NPs had a minor influence on the generation of intracellular ROS. On the other hand, uncoupling of AM-005 uptake with NP internalization into cells failed to induce ROS synthesis. Overall, our approach achieved two-fold increase in suppressing the viability of tumor cells in vitro and the growth of tumors in vivo. We conclude that magnetite NPs can be used as pH responsive nanocarriers that are able to improve the efficacy of AKIs.

  4. Penetration dynamics of the ring current into the plasmasphere during substorms by the observation of diffuse aurora and SAR arc

    International Nuclear Information System (INIS)

    Complete text of publication follows. Observations of the diffuse aurora (DA) and stable auroral red (SAR) arc are the informative investigation method of magnetosphere-ionosphere coupling in the vicinity of plasmapause and inner boundary of the plasma sheet during magnetospheric disturbances. SAR arcs are the consequence of interaction of the outer plasmasphere (plasmapause) with energetic ions of the ring current. The DA is caused by the low-energy electron precipitation from the plasma sheet. During substorms we observe the intensity increase of DA and its equatorward extension up to the plasmapause projection which is mapped by the SAR arc occurring at that time. (Ievenko et al, Adv. Space Res., 2008). In this work we present the new study results of the DA and SAR arc dynamics based on spectrophotometric observations at the Yakutsk meridian (199deg E geomagnetic longitude). For individual events the relationship of equatorward extension of the DA in the 557,7 nm emission to the magnetospheric convection intensification after the turn of IMF BZ to the south is shown. The longitudinal dynamics of SAR arc formation during the substorm expansion phase is investigated. The connection of SAR arc occurrence with the substorm injection by the geosynchronous measurements is analyzed. It is assumed that the interval of latitudes where SAR arcs are observed during weak and moderate storms is a statistical map of the outer plasmasphere region, into which the developing ring current penetrates and damps during substorms.

  5. Aparcería y disposición en una hacienda cafetera del Tolima (La Aurora, 1948-1993

    Directory of Open Access Journals (Sweden)

    Anrup, Rolando

    1996-06-01

    Full Text Available Not available.

    El artículo cuestiona los diferentes tipos de transformación administrativo-laboral en los cultivos de café de la hacienda La Aurora, ubicada en la región del Líbano (Colombia. El estudio toma en cuenta las formas cambiantes de disposición desarrolladas en el caso específico del norte del departamento del Tolima, una de las zonas de mayor producción cafetera a nivel nacional y una de las áreas donde con mayor intensidad se vivieron los estragos de la violencia de los años 50 y 60. Los elementos metodológicos para su interpretación son considerados como una aproximación realista en torno al concepto de propiedad. Su análisis explora los diferentes grados de disposición que ejerce el hacendado sobre los objetos en una determinada estructura de disposición.

  6. IMF dependence of Saturn's auroras: modelling study of HST and Cassini data from 12–15 February 2008

    Directory of Open Access Journals (Sweden)

    E. S. Belenkaya

    2010-08-01

    Full Text Available To gain better understanding of auroral processes in Saturn's magnetosphere, we compare ultraviolet (UV auroral images obtained by the Hubble Space Telescope (HST with the position of the open-closed field line boundary in the ionosphere calculated using a magnetic field model that employs Cassini measurements of the interplanetary magnetic field (IMF as input. Following earlier related studies of pre-orbit insertion data from January 2004 when Cassini was located ~ 1300 Saturn radii away from the planet, here we investigate the interval 12–15 February 2008, when UV images of Saturn's southern dayside aurora were obtained by the HST while the Cassini spacecraft measured the IMF in the solar wind just upstream of the dayside bow shock. This configuration thus provides an opportunity, unique to date, to determine the IMF impinging on Saturn's magnetosphere during imaging observations, without the need to take account of extended and uncertain interplanetary propagation delays. The paraboloid model of Saturn's magnetosphere is then employed to calculate the magnetospheric magnetic field structure and ionospheric open-closed field line boundary for averaged IMF vectors that correspond, with appropriate response delays, to four HST images. We show that the IMF-dependent open field region calculated from the model agrees reasonably well with the area lying poleward of the UV emissions, thus supporting the view that the poleward boundary of Saturn's auroral oval in the dayside ionosphere lies adjacent to the open-closed field line boundary.

  7. Aurora A Kinase Regulates Mammary Epithelial Cell Fate by Determining Mitotic Spindle Orientation in a Notch-Dependent Manner

    Directory of Open Access Journals (Sweden)

    Joseph L. Regan

    2013-07-01

    Full Text Available Cell fate determination in the progeny of mammary epithelial stem/progenitor cells remains poorly understood. Here, we have examined the role of the mitotic kinase Aurora A (AURKA in regulating the balance between basal and luminal mammary lineages. We find that AURKA is highly expressed in basal stem cells and, to a lesser extent, in luminal progenitors. Wild-type AURKA expression promoted luminal cell fate, but expression of an S155R mutant reduced proliferation, promoted basal fate, and inhibited serial transplantation. The mechanism involved regulation of mitotic spindle orientation by AURKA and the positioning of daughter cells after division. Remarkably, this was NOTCH dependent, as NOTCH inhibitor blocked the effect of wild-type AURKA expression on spindle orientation and instead mimicked the effect of the S155R mutant. These findings directly link AURKA, NOTCH signaling, and mitotic spindle orientation and suggest a mechanism for regulating the balance between luminal and basal lineages in the mammary gland.

  8. North Slope, Alaska ESI: FACILITY (Facility Points)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains data for oil field facilities for the North Slope of Alaska. Vector points in this data set represent oil field facility locations. This data...

  9. [Interior] Configuration options, habitability and architectural aspects of the transfer habitat module (THM) and the surface habitat on Mars (SHM)/ESA's AURORA human mission to Mars (HMM) study

    Science.gov (United States)

    Imhof, Barbara

    2007-02-01

    This paper discusses the findings for [Interior] configuration options, habitability and architectural aspects of a first human spacecraft to Mars. In 2003 the space architecture office LIQUIFER was invited by the European Space Agency's (ESA) AURORA Program committee to consult the scientists and engineers from the European Space and Technology Center (ESTEC) and other European industrial communities with developing the first human mission to Mars, which will take place in 2030, regarding the architectural issues of crewed habitats. The task was to develop an interior configuration for a transfer vehicle (TV) to Mars, especially a transfer habitation module (THM) and a surface habitat module (SHM) on Mars. The total travel time Earth—Mars and back for a crew of six amounts to approximately 900 days. After a 200-day-flight three crewmembers will land on Mars in the Mars excursion vehicle (MEV) and will live and work in the SHM for 30 days. For 500 days before the 200-day journey back the spacecraft continues to circle the Martian orbit for further exploration. The entire mission program is based on our present knowledge of technology. The project was compiled during a constant feedback-design process and trans-disciplinary collaboration sessions in the ESA-ESTEC concurrent design facility. Long-term human space flight sets new spatial conditions and requirements to the design concept. The guidelines were developed from relevant numbers and facts of recognized standards, interviews with astronauts/cosmonauts and from analyses about habitability, sociology, psychology and configuration concepts of earlier space stations in combination with the topics of the individual's perception and relation of space. Result of this study is the development of a prototype concept for the THM and SHM with detailed information and complete plans of the interior configuration, including mass calculations. In addition the study contains a detailed explanation of the development of

  10. Air Quality Facilities

    Data.gov (United States)

    Iowa State University GIS Support and Research FacilityFacilities with operating permits for Title V of the Federal Clean Air Act, as well as facilities required to submit an air emissions inventory, and other...

  11. Basic Research Firing Facility

    Data.gov (United States)

    Federal Laboratory Consortium — The Basic Research Firing Facility is an indoor ballistic test facility that has recently transitioned from a customer-based facility to a dedicated basic research...

  12. Facility Registry Service (FRS)

    Data.gov (United States)

    U.S. Environmental Protection Agency — The Facility Registry Service (FRS) provides an integrated source of comprehensive (air, water, and waste) environmental information about facilities across EPA,...

  13. Licensed Healthcare Facilities

    Data.gov (United States)

    California Department of Resources — The Licensed Healthcare Facilities point layer represents the locations of all healthcare facilities licensed by the State of California, Department of Health...

  14. High Throughput Facility

    Data.gov (United States)

    Federal Laboratory Consortium — Argonne?s high throughput facility provides highly automated and parallel approaches to material and materials chemistry development. The facility allows scientists...

  15. Guide to research facilities

    Energy Technology Data Exchange (ETDEWEB)

    1993-06-01

    This Guide provides information on facilities at US Department of Energy (DOE) and other government laboratories that focus on research and development of energy efficiency and renewable energy technologies. These laboratories have opened these facilities to outside users within the scientific community to encourage cooperation between the laboratories and the private sector. The Guide features two types of facilities: designated user facilities and other research facilities. Designated user facilities are one-of-a-kind DOE facilities that are staffed by personnel with unparalleled expertise and that contain sophisticated equipment. Other research facilities are facilities at DOE and other government laboratories that provide sophisticated equipment, testing areas, or processes that may not be available at private facilities. Each facility listing includes the name and phone number of someone you can call for more information.

  16. ``A red cross appeared in the sky'' and other celestial signs: Presumable European aurorae in the mid AD 770s were halo displays

    Science.gov (United States)

    Neuhäuser, D. L.; Neuhäuser, R.

    2015-12-01

    The interpretation of the strong 14C variation around AD 775 as one (or several) solar super-flare(s) by, e.g., Usoskin et al. (2013) is based on alleged aurora sightings in the mid AD 770s in Europe: A red cross/crucifix in AD 773/4/6 from the Anglo-Saxon Chronicle, inflamed shields in AD 776 (both listed in the aurora catalogue of Link 1962), and riders on white horses in AD 773 (newly proposed as aurora in Usoskin et al. 2013), the two latter from the Royal Frankish Annals. We discuss the reports about these three sightings in detail here. We can show that all three can be interpreted convincingly as halo displays: The red cross or crucifix is formed by the horizontal arc and a vertical pillar of light (either with the Sun during sunset or with the moon after sunset); the inflamed shields and the riders on white horses were both two mock suns, especially the latter narrated in form of a Christian adaptation of the antique dioscuri motive. While the latter event took place early in AD 774 (dated AD 773 in Usoskin et al. 2013), the two other sightings have to be dated AD 776, i.e. anyway too late for being in connection with a 14C rise that started before AD 775. We also sketch the ideological background of those sightings and there were many similar reports throughout that time. In addition, we present a small drawing of a lunar halo display with horizontal arc and vertical pillar forming a cross for shortly later, namely AD 806 June 4, the night of full moon, also from the Anglo-Saxon Chronicle; we also show historic observations of halo phenomena (mock suns and crosses) from G. Kirch and Hevelius - and a modern photograph.

  17. High Chromosome Number in hematological cancer cell lines is a Negative Predictor of Response to the inhibition of Aurora B and C by GSK1070916

    Directory of Open Access Journals (Sweden)

    Hardwicke Mary

    2011-07-01

    Full Text Available Abstract Background Aurora kinases play critical roles in mitosis and are being evaluated as therapeutic targets in cancer. GSK1070916 is a potent, selective, ATP competitive inhibitor of Aurora kinase B and C. Translation of predictive biomarkers to the clinic can benefit patients by identifying the tumors that are more likely to respond to therapies, especially novel inhibitors such as GSK1070916. Methods 59 Hematological cancer-derived cell lines were used as models for response where in vitro sensitivity to GSK1070916 was based on both time and degree of cell death. The response data was analyzed along with karyotype, transcriptomics and somatic mutation profiles to determine predictors of response. Results 20 cell lines were sensitive and 39 were resistant to treatment with GSK1070916. High chromosome number was more prevalent in resistant cell lines (p-value = 0.0098, Fisher Exact Test. Greater resistance was also found in cell lines harboring polyploid subpopulations (p-value = 0.00014, Unpaired t-test. A review of NOTCH1 mutations in T-ALL cell lines showed an association between NOTCH1 mutation status and chromosome number (p-value = 0.0066, Fisher Exact Test. Conclusions High chromosome number associated with resistance to the inhibition of Aurora B and C suggests cells with a mechanism to bypass the high ploidy checkpoint are resistant to GSK1070916. High chromosome number, a hallmark trait of many late stage hematological malignancies, varies in prevalence among hematological malignancy subtypes. The high frequency and relative ease of measurement make high chromosome number a viable negative predictive marker for GSK1070916.

  18. Self-consistent electrostatic simulations of reforming double layers in the downward current region of the aurora

    International Nuclear Information System (INIS)

    The plasma on a magnetic field line in the downward current region of the aurora is simulated using a Vlasov model. It is found that an electric field parallel to the magnetic fields is supported by a double layer moving toward higher altitude. The double layer accelerates electrons upward, and these electrons give rise to plasma waves and electron phase-space holes through beam-plasma interaction. The double layer is disrupted when reaching altitudes of 1- 2 Earth radii where the Langmuir condition no longer can be satisfied due to the diminishing density of electrons coming up from the ionosphere. During the disruption the potential drop is in part carried by the electron holes. The disruption creates favourable conditions for double layer formation near the ionosphere and double layers form anew in that region. The process repeats itself with a period of approximately 1 min. This period is determined by how far the double layer can reach before being disrupted: a higher disruption altitude corresponds to a longer repetition period. The disruption altitude is, in turn, found to increase with ionospheric density and to decrease with total voltage. The current displays oscillations around a mean value. The period of the oscillations is the same as the recurrence period of the double layer formations. The oscillation amplitude increases with increasing voltage, whereas the mean value of the current is independent of voltage in the 100 to 800V range covered by our simulations. Instead, the mean value of the current is determined by the electron density at the ionospheric boundary.

  19. Variation of Jupiter's aurora observed by Hisaki/EXCEED: 2. Estimations of auroral parameters and magnetospheric dynamics

    Science.gov (United States)

    Tao, Chihiro; Kimura, Tomoki; Badman, Sarah V.; André, Nicolas; Tsuchiya, Fuminori; Murakami, Go; Yoshioka, Kazuo; Yoshikawa, Ichiro; Yamazaki, Atsushi; Fujimoto, Masaki

    2016-05-01

    Jupiter's auroral parameters are estimated from observations by a spectrometer EXCEED (Extreme Ultraviolet Spectroscope for Exospheric Dynamics) on board Japanese Aerospace Exploration Agency's Earth-orbiting planetary space telescope Hisaki. EXCEED provides continuous auroral spectra covering the wavelength range over 80-148 nm from the whole northern polar region. The auroral electron energy is estimated using a hydrocarbon color ratio adopted for the wavelength range of EXCEED, and the emission power in the long wavelength range 138.5-144.8 nm is used as an indicator of total emitted power before hydrocarbon absorption and auroral electron energy flux. The quasi-continuous observations by Hisaki provide the auroral electron parameters and their relation under different auroral activity levels. Short- (within one planetary rotation) enhancements of auroral power accompany increases of the electron number flux rather than the electron energy variations. The relationships between the auroral electron energy (~70-400 keV) and flux (1026-1027/s, 0.08-0.9 μA/m2) estimated from the observations over a 40 day interval are in agreement with field-aligned acceleration theory when incorporating probable magnetospheric parameters. Applying the electron acceleration theory to each observation point, we explore the magnetospheric source plasma variation during these power-enhanced events. Possible scenarios to explain the derived variations are (i) an adiabatic variation of the magnetospheric plasma under a magnetospheric compression and/or plasma injection, and (ii) a change of the dominant auroral component from the main emission (main aurora) to the emission at the open-closed boundary.

  20. Fine scale structures of pulsating auroras in the early recovery phase of substorm using ground-based EMCCD camera

    Science.gov (United States)

    Nishiyama, Takanori; Sakanoi, Takeshi; Miyoshi, Yoshizumi; Kataoka, Ryuho; Hampton, Donald; Katoh, Yuto; Asamura, Kazushi; Okano, Shoichi

    2012-10-01

    We have carried out ground-based observations, optimized to temporal and spatial characteristics of pulsating auroras (PAs) in the micro/meso scale, using an electron multiplying charge coupled device (EMCCD) camera with a wide field of view corresponding to 100 × 100 km at an altitude of 110 km and a high sampling rate up to 100 frames per second. We focus on transient PAs propagating southward around 1100 UT, in the early recovery phase of the substorm, on 4th March 2011. Three independent patches (PA1-3) each with different periods between 4 and 7 s were observed, which means that the periodicity was not explained by the electron bounce motion and strongly depended on local plasma conditions in the magnetosphere or in the ionosphere. One more insight is that only PA1 had also a sharp peak of modulations around 1.5 Hz, with a narrow frequency width of 0.30 Hz, and the strong modulations existed as a small spot in the center of PA1. We have also conducted cross spectrum analysis and have obtained coherence and phase distributions for auroral variations between 0.1 and 3.0 Hz. The results indicated that low frequency variations from 0.2 to 0.5 Hz inside PA1-3 propagated as a collective motion in well-defined directions. The estimated horizontal propagation velocities ranged from 50 to 120 km/s at the auroral altitude. The velocities are almost consistent with the Alfven speed at the magnetic equator, which suggests that compressional waves have an effect on PA via modulations of the ambient plasma environment.

  1. Aurora Kinase A expression predicts platinum-resistance and adverse outcome in high-grade serous ovarian carcinoma patients.

    Science.gov (United States)

    Mignogna, Chiara; Staropoli, Nicoletta; Botta, Cirino; De Marco, Carmela; Rizzuto, Antonia; Morelli, Michele; Di Cello, Annalisa; Franco, Renato; Camastra, Caterina; Presta, Ivan; Malara, Natalia; Salvino, Angela; Tassone, Pierfrancesco; Tagliaferri, Pierosandro; Barni, Tullio; Donato, Giuseppe; Di Vito, Anna

    2016-01-01

    High-Grade Serous Ovarian Carcinoma (HGSOC) is the predominant histotype of epithelial ovarian cancer (EOC), characterized by advanced stage at diagnosis, frequent TP53 mutation, rapid progression, and high responsiveness to platinum-based-chemotherapy. To date, standard first-line-chemotherapy in advanced EOC includes platinum salts and paclitaxel with or without bevacizumab. The major prognostic factor is the response duration from the end of the platinum-based treatment (platinum-free interval) and about 10-0 % of EOC patients bear a platinum-refractory disease or develop early resistance (platinum-free interval shorter than 6 months). On these bases, a careful selection of patients who could benefit from chemotherapy is recommended to avoid unnecessary side effects and for a better disease outcome. In this retrospective study, an immunohistochemical evaluation of Aurora Kinase A (AURKA) was performed on 41 cases of HGSOC according to platinum-status. Taking into account the number and intensity of AURKA positive cells we built a predictive score able to discriminate with high accuracy platinum-sensitive patients from platinum-resistant patients (p < 0.001). Furthermore, we observed that AURKA overexpression correlates to worse overall survival (p = 0.001; HR 0.14). We here suggest AURKA as new effective tool to predict the biological behavior of HGSOC. Particularly, our results indicate that AURKA has a role both as predictor of platinum-resistance and as prognostic factor, that deserves further investigation in prospective clinical trials. Indeed, in the era of personalized medicine, AURKA could assist the clinicians in selecting the best treatment and represent, at the same time, a promising new therapeutic target in EOC treatment. PMID:27209210

  2. Near Simultaneous Observations of the Aurora From FUV, Particle and Photometric Instruments on DMSP-F16, TIMED, and IMAGE

    Science.gov (United States)

    Hecht, J. H.; Strickland, D. J.; Knight, H. K.; Kochenash, A. J.; Zhang, Y.; Morrison, M. D.; Paxton, L. J.; Mende, S. B.; Frey, H. U.; Burke, W. J.; Rich, F. J.

    2005-12-01

    With the launch of DMSP F16 there are now three FUV remote sensing instruments which measure auroral emissions originating from the impact of electrons and protons on atmospheric constituents. These instruments are the FUV cameras on IMAGE which generally observes from HEO (approximately 7 Re apogee), the GUVI instrument on TIMED, and the SSUSI instrument on F16 which are in LEO. The Image cameras measure the OI (1356) emission, Ly-alpha, and the N2 LBH bands. GUVI, although a spectrograph, generally produces images in 5 colors (Ly-alpha, OI(1304), OI(1356), LBH-short and LBH-long). SSUSI is at a slightly higher altitude and includes a spectrograph that is essentially identical to the GUVI instrument. All these data can be used to determine the energetics of the auroral precipitation using algorithms. Unique to DMSP are two other instruments, J5, a particle sensor which measures electron and proton fluxes from 30 eV to 30 keV, and as part of SSUSI, a multi-channel photometer measuring two emission (N2+(4278) and OI(6300)) which are often used in ground-based applications to measure auroral particle energetics. In a companion paper (Knight et al.) a statistical analysis is given on how well the SSUSI spectrograph derived energy flux, Q, is compared to the J5 measured Q. In this paper we present results for several individual events where data can be obtained from most or all of these five instruments. The results for Q and the average energy of the particle flux are compared. In particular, we look at whether there is any significant difference between these derived quantities during proton-dominated and electron-dominated aurorae.

  3. Expression of aurora kinase A is associated with metastasis-free survival in node-negative breast cancer patients

    International Nuclear Information System (INIS)

    Inhibitors targeting the cell cycle-regulated aurora kinase A (AURKA) are currently being developed. Here, we examine the prognostic impact of AURKA in node-negative breast cancer patients without adjuvant systemic therapy (n = 766). AURKA was analyzed using microarray-based gene-expression data from three independent cohorts of node-negative breast cancer patients. In multivariate Cox analyses, the prognostic impact of age, histological grade, tumor size, estrogen receptor (ER), and HER2 were considered. Patients with higher AURKA expression had a shorter metastasis-free survival (MFS) in the Mainz (HR 1.93; 95% CI 1.34 – 2.78; P < 0.001), Rotterdam (HR 1.95; 95% CI 1.45– 2.63; P<0.001) and Transbig (HR 1.52; 95% CI 1.14–2.04; P=0.005) cohorts. AURKA was also associated with MFS in the molecular subtype ER+/HER2- carcinomas (HR 2.10; 95% CI 1.70–2.59; P<0.001), but not in ER-/HER2- nor in HER2+ carcinomas. In the multivariate Cox regression adjusted to age, grade and tumor size, AURKA showed independent prognostic significance in the ER+/HER2- subtype (HR 1.73; 95% CI 1.24–2.42; P=0.001). Prognosis of patients in the highest quartile of AURKA expression was particularly poor. In addition, AURKA correlated with the proliferation metagene (R=0.880; P<0.001), showed a positive association with grade (P<0.001), tumor size (P<0.001) and HER2 (P<0.001), and was inversely associated with ER status (P<0.001). AURKA is associated with worse prognosis in estrogen receptor positive breast carcinomas. Patients with the highest AURKA expression (>75% percentile) have a particularly bad prognosis and may profit from therapy with AURKA inhibitors

  4. Self-consistent electrostatic simulations of reforming double layers in the downward current region of the aurora

    Science.gov (United States)

    Gunell, H.; Andersson, L.; De Keyser, J.; Mann, I.

    2015-10-01

    The plasma on a magnetic field line in the downward current region of the aurora is simulated using a Vlasov model. It is found that an electric field parallel to the magnetic fields is supported by a double layer moving toward higher altitude. The double layer accelerates electrons upward, and these electrons give rise to plasma waves and electron phase-space holes through beam-plasma interaction. The double layer is disrupted when reaching altitudes of 1-2 Earth radii where the Langmuir condition no longer can be satisfied due to the diminishing density of electrons coming up from the ionosphere. During the disruption the potential drop is in part carried by the electron holes. The disruption creates favourable conditions for double layer formation near the ionosphere and double layers form anew in that region. The process repeats itself with a period of approximately 1 min. This period is determined by how far the double layer can reach before being disrupted: a higher disruption altitude corresponds to a longer repetition period. The disruption altitude is, in turn, found to increase with ionospheric density and to decrease with total voltage. The current displays oscillations around a mean value. The period of the oscillations is the same as the recurrence period of the double layer formations. The oscillation amplitude increases with increasing voltage, whereas the mean value of the current is independent of voltage in the 100 to 800 V range covered by our simulations. Instead, the mean value of the current is determined by the electron density at the ionospheric boundary.

  5. Self-consistent electrostatic simulations of reforming double layers in the downward current region of the aurora

    Energy Technology Data Exchange (ETDEWEB)

    Gunell, H.; Keyser, J. de [Belgian Institute for Space Aeronomy, Brussels (Belgium); Andersson, L. [Colorado Univ., Boulder, CO (United States). Lab. for Atmospheric and Space Physics; Mann, I. [EISCAT Scientific Association, Kiruna (Sweden); Umeaa Univ. (Sweden). Dept. of Physics

    2015-07-01

    The plasma on a magnetic field line in the downward current region of the aurora is simulated using a Vlasov model. It is found that an electric field parallel to the magnetic fields is supported by a double layer moving toward higher altitude. The double layer accelerates electrons upward, and these electrons give rise to plasma waves and electron phase-space holes through beam-plasma interaction. The double layer is disrupted when reaching altitudes of 1- 2 Earth radii where the Langmuir condition no longer can be satisfied due to the diminishing density of electrons coming up from the ionosphere. During the disruption the potential drop is in part carried by the electron holes. The disruption creates favourable conditions for double layer formation near the ionosphere and double layers form anew in that region. The process repeats itself with a period of approximately 1 min. This period is determined by how far the double layer can reach before being disrupted: a higher disruption altitude corresponds to a longer repetition period. The disruption altitude is, in turn, found to increase with ionospheric density and to decrease with total voltage. The current displays oscillations around a mean value. The period of the oscillations is the same as the recurrence period of the double layer formations. The oscillation amplitude increases with increasing voltage, whereas the mean value of the current is independent of voltage in the 100 to 800V range covered by our simulations. Instead, the mean value of the current is determined by the electron density at the ionospheric boundary.

  6. Aurora Kinase A Is Not Involved in CPEB1 Phosphorylation and cyclin B1 mRNA Polyadenylation during Meiotic Maturation of Porcine Oocytes

    Czech Academy of Sciences Publication Activity Database

    Komrsková, Pavla; Šušor, Andrej; Malík, Radek; Procházková, Barbora; Lišková, Lucie; Šupolíková, Jaroslava; Hladký, Štěpán; Kubelka, Michal

    2014-01-01

    Roč. 9, č. 7 (2014), e101222-e101222. E-ISSN 1932-6203 R&D Projects: GA ČR GAP502/10/0944; GA ČR GA13-12291S; GA ČR GAP502/12/2201 Institutional support: RVO:67985904 ; RVO:68378050 Keywords : Aurora Kinase A Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 3.234, year: 2014 http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0101222

  7. Reliable Facility Location Problem with Facility Protection.

    Science.gov (United States)

    Tang, Luohao; Zhu, Cheng; Lin, Zaili; Shi, Jianmai; Zhang, Weiming

    2016-01-01

    This paper studies a reliable facility location problem with facility protection that aims to hedge against random facility disruptions by both strategically protecting some facilities and using backup facilities for the demands. An Integer Programming model is proposed for this problem, in which the failure probabilities of facilities are site-specific. A solution approach combining Lagrangian Relaxation and local search is proposed and is demonstrated to be both effective and efficient based on computational experiments on random numerical examples with 49, 88, 150 and 263 nodes in the network. A real case study for a 100-city network in Hunan province, China, is presented, based on which the properties of the model are discussed and some managerial insights are analyzed. PMID:27583542

  8. AOV Facility Tool/Facility Safety Specifications

    Data.gov (United States)

    Department of Transportation — Develop and maintain authorizing documents that are standards that facilities must follow. These standards are references of FAA regulations and are specific to the...

  9. Introduction of the 2007-2008 JOGMEC/NRCan/Aurora Mallik Gas Hydrate Production Research Program, NWT, Canada

    Science.gov (United States)

    Yamamoto, K.; Dallimore, S. R.; Numasawa, M.; Yasuda, M.; Fujii, T.; Fujii, K.; Wright, J.; Nixon, F.

    2007-12-01

    Japan Oil, Gas and Metals National Corporation (JOGMEC) and Natural Resource Canada (NRCan) have embarked on a new research program to study the production potential of gas hydrates. The program is being carried out at the Mallik gas hydrate field in the Mackenzie Delta, a location where two previous scientific investigations have been carried in 1998 and 2002. In the 2002 program that was undertaken by seven partners from five countries, 468m3 of gas flow was measured during 124 hours of thermal stimulation using hot warm fluid. Small-scale pressure drawdown tests were also carried out using Schlumberger's Modular Dynamics Tester (MDT) wireline tool, gas flow was observed and the inferred formation permeabilities suggested the possible effectiveness of the simple depressurization method. While the testing undertaken in 2002 can be cited as the first well constrained gas production from a gas hydrate deposit, the results fell short of that required to fully calibrate reservoir simulation models or indeed establish the technical viability of long term production from gas hydrates. The objectives of the current JOGMEC/NRCan/Aurora Mallik production research program are to undertake longer term production testing to further constrain the scientific unknowns and to demonstrate the technical feasibility of sustained gas hydrate production using the depressurization method. A key priority is to accurately measure water and gas production using state-of-art production technologies. The primary production test well was established during the 2007 field season with the re-entry and deepening of JAPEX/JNOC/GSC Mallik 2L-38 well, originally drilled in 1998. Production testing was carried out in April of 2007 under a relatively low drawdown pressure condition. Flow of methane gas was measured from a 12m perforated interval of gas-hydrate-saturated sands from 1093 to 1105m. The results establish the potential of the depressurization method and provide a basis for future

  10. Renzo Ramírez Bacca. Historia Laboral de una hacienda cafetera: La Aurora, 1882-1982

    Directory of Open Access Journals (Sweden)

    Jesús Fernando Barrios Ordóñez

    2011-08-01

    Full Text Available Normal 0 21 false false false ES-CO X-NONE X-NONE MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Tabla normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin-top:0cm; mso-para-margin-right:0cm; mso-para-margin-bottom:10.0pt; mso-para-margin-left:0cm; line-height:115%; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;} El libro de Renzo Ramírez Bacca, historiador y profesor asociado adscrito al Departamento de Historia de la Universidad Nacional de Colombia, sede Medellín, es el resultado de una investigación profunda y documentada que tiene como propósito analizar los sistemas de organización laboral y las formas de ordenamiento administrativo y productivo en la hacienda cafetera La Aurora, ubicada en el actual municipio de El Líbano, en el departamento del Tolima. Esta hacienda fue una de las mayores del norte del Tolima, en la cual se adoptaron sistemas modernos de producción, relacionados, en un principio, con el sistema de aparcería, categoría de trabajadores permanentes con base en la fuerza de trabajo familiar, bajo la figura de arrendatarios, tabloneros, contratistas, partijeros y agregados. Posteriormente, la tecnificación cafetera se sustituye por la administración directa, que utiliza fuerza de trabajo asalariada temporal, modificando las relaciones laborales de tipo familiar que prevalecían en la hacienda.

  11. Armament Technology Facility (ATF)

    Data.gov (United States)

    Federal Laboratory Consortium — The Armament Technology Facility is a 52,000 square foot, secure and environmentally-safe, integrated small arms and cannon caliber design and evaluation facility....

  12. Financing Professional Sports Facilities

    OpenAIRE

    Baade, Robert A.; Victor A. Matheson

    2011-01-01

    This paper examines public financing of professional sports facilities with a focus on both early and recent developments in taxpayer subsidization of spectator sports. The paper explores both the magnitude and the sources of public funding for professional sports facilities.

  13. Explosive Components Facility

    Data.gov (United States)

    Federal Laboratory Consortium — The 98,000 square foot Explosive Components Facility (ECF) is a state-of-the-art facility that provides a full-range of chemical, material, and performance analysis...

  14. The Educational Facilities Charrette

    Science.gov (United States)

    Chase, William W.

    1970-01-01

    The deputy director for the Division of Facilities Development of the U.S. Office of Education discusses a technique for studying and resolving educational facilities development problems within the context of total community planning needs." (Author/AA)

  15. Ouellette Thermal Test Facility

    Data.gov (United States)

    Federal Laboratory Consortium — The Thermal Test Facility is a joint Army/Navy state-of-the-art facility (8,100 ft2) that was designed to: Evaluate and characterize the effect of flame and thermal...

  16. Health Facility General Information

    Data.gov (United States)

    U.S. Department of Health & Human Services — This dataset contains the locations of Article 28, Article 36 and Article 40 health care facilities and programs from the Health Facilities Information System...

  17. Projectile Demilitarization Facilities

    Data.gov (United States)

    Federal Laboratory Consortium — The Projectile Wash Out Facility is US Army Ammunition Peculiar Equipment (APE 1300). It is a pilot scale wash out facility that uses high pressure water and steam...

  18. Dialysis Facility Compare

    Data.gov (United States)

    U.S. Department of Health & Human Services — Dialysis Facility Compare helps you find detailed information about Medicare-certified dialysis facilities. You can compare the services and the quality of care...

  19. Facility Response Plan (FRP)

    Data.gov (United States)

    U.S. Environmental Protection Agency — A Facility Response Plan (FRP) demonstrates a facility's preparedness to respond to a worst case oil discharge. Under the Clean Water Act, as amended by the Oil...

  20. Energetics Conditioning Facility

    Data.gov (United States)

    Federal Laboratory Consortium — The Energetics Conditioning Facility is used for long term and short term aging studies of energetic materials. The facility has 10 conditioning chambers of which 2...

  1. Wastewater Treatment Facilities

    Data.gov (United States)

    Iowa State University GIS Support and Research Facility — Individual permits for municipal, industrial, and semi-public wastewater treatment facilities in Iowa for the National Pollutant Discharge Elimination System...

  2. A Functionally Superior Second-Generation Vector Expressing an Aurora Kinase-A-Specific T-Cell Receptor for Anti-Leukaemia Adoptive Immunotherapy.

    Science.gov (United States)

    Casey, Nicholas Paul; Fujiwara, Hiroshi; Tanimoto, Kazushi; Okamoto, Sachiko; Mineno, Junichi; Kuzushima, Kiyotaka; Shiku, Hiroshi; Yasukawa, Masaki

    2016-01-01

    Aurora Kinase A is a cancer-associated protein normally involved in the regulation of mitosis. Being over-expressed in a range of cancers, it is a suitable target for cell-based immunotherapy. Gene transfer of T-cell receptor sequences cognisant of HLA-A*0201-restricted Aurora Kinase A antigen has previously been shown to transfer specific immunoreactivity against the target peptide in a Human Lymphocyte Antigen-restricted manner. While T cell receptor gene-transfer has great potential in overcoming the difficulties of isolating and expanding tumour-reactive lymphocytes from a patient's own cells, one hurdle is potential mispairing and competition between exogenous and endogenous T cell receptor chains. We have used a retroviral vector design bearing a short-interfering RNA that downregulates endogenous T cell receptor chains, without affecting expression of the transgenic T cell receptor sequences. The T cell receptor expression cassette also includes a 2A self-cleaving peptide, resulting in equimolar expression of the T cell receptor alpha and beta chains, further enhancing formation of the desired T cell receptor. Via a simple, modular cloning method, we have cloned the alpha and beta chains of the anti-Aurora Kinase A-reactive T cell receptor into this 'siTCR' vector. We then compared the activity of this vector against the original, 'conventional' vector across a panel of assays. T cell receptors expressed from the siTCR-vector retained the cytotoxic functionality of the original vector, with evidence of reduced off-target reactivity. The rate of expression of correctly-formed T cell receptors was superior using the siTCR design, and this was achieved at lower vector copy numbers. Maintaining T cell receptor efficacy with a reduced vector copy number reduces the risk of genotoxicity. The siTCR design also reduces the risk of mispairing and cross-reactivity, while increasing the functional titre. Such improvements in the safety of T cell receptor gene

  3. A Functionally Superior Second-Generation Vector Expressing an Aurora Kinase-A-Specific T-Cell Receptor for Anti-Leukaemia Adoptive Immunotherapy.

    Directory of Open Access Journals (Sweden)

    Nicholas Paul Casey

    Full Text Available Aurora Kinase A is a cancer-associated protein normally involved in the regulation of mitosis. Being over-expressed in a range of cancers, it is a suitable target for cell-based immunotherapy. Gene transfer of T-cell receptor sequences cognisant of HLA-A*0201-restricted Aurora Kinase A antigen has previously been shown to transfer specific immunoreactivity against the target peptide in a Human Lymphocyte Antigen-restricted manner. While T cell receptor gene-transfer has great potential in overcoming the difficulties of isolating and expanding tumour-reactive lymphocytes from a patient's own cells, one hurdle is potential mispairing and competition between exogenous and endogenous T cell receptor chains. We have used a retroviral vector design bearing a short-interfering RNA that downregulates endogenous T cell receptor chains, without affecting expression of the transgenic T cell receptor sequences. The T cell receptor expression cassette also includes a 2A self-cleaving peptide, resulting in equimolar expression of the T cell receptor alpha and beta chains, further enhancing formation of the desired T cell receptor. Via a simple, modular cloning method, we have cloned the alpha and beta chains of the anti-Aurora Kinase A-reactive T cell receptor into this 'siTCR' vector. We then compared the activity of this vector against the original, 'conventional' vector across a panel of assays. T cell receptors expressed from the siTCR-vector retained the cytotoxic functionality of the original vector, with evidence of reduced off-target reactivity. The rate of expression of correctly-formed T cell receptors was superior using the siTCR design, and this was achieved at lower vector copy numbers. Maintaining T cell receptor efficacy with a reduced vector copy number reduces the risk of genotoxicity. The siTCR design also reduces the risk of mispairing and cross-reactivity, while increasing the functional titre. Such improvements in the safety of T cell

  4. P-glycoprotein and breast cancer resistance protein in acute myeloid leukaemia cells treated with the Aurora-B Kinase Inhibitor barasertib-hQPA

    International Nuclear Information System (INIS)

    Aurora kinases play an essential role in orchestrating chromosome alignment, segregation and cytokinesis during mitotic progression, with both aurora-A and B frequently over-expressed in a variety of human malignancies. Over-expression of the ABC drug transporter proteins P-glycoprotein (Pgp) and Breast cancer resistance protein (BCRP) is a major obstacle for chemotherapy in many tumour types with Pgp conferring particularly poor prognosis in acute myeloid leukaemia (AML). Barasertib-hQPA is a highly selective inhibitor of aurora-B kinase that has shown tumouricidal activity against a range tumour cell lines including those of leukaemic AML origin. Effect of barasertib-hQPA on the pHH3 biomarker and cell viability was measured in a panel of leukaemic cell lines and 37 primary AML samples by flow cytometry. Pgp status was determined by flow cytometry and BCRP status by flow cytometry and real-time PCR. In this study we report the creation of the cell line OCI-AML3DNR, which over-expresses Pgp but not BCRP or multidrug resistance-associated protein (MRP), through prolonged treatment of OCI-AML3 cells with daunorubicin. We demonstrate that Pgp (OCI-AML3DNR and KG-1a) and BCRP (OCI-AML6.2) expressing AML cell lines are less sensitive to barasertib-hQPA induced pHH3 inhibition and subsequent loss of viability compared to transporter negative cell lines. We also show that barasertib-hQPA resistance in these cell lines can be reversed using known Pgp and BCRP inhibitors. We report that barasertib-hQPA is not an inhibitor of Pgp or BCRP, but by using 14[C]-barasertib-hQPA that it is effluxed by these transporters. Using phosphoHistone H3 (pHH3) as a biomarker of barasertib-hQPA responsiveness in primary AML blasts we determined that Pgp and BCRP positive primary samples were less sensitive to barasertib-hQPA induced pHH3 inhibition (p = <0.001) than samples without these transporters. However, we demonstrate that IC50 inhibition of pHH3 by barasertib-hQPA was achieved in

  5. P-glycoprotein and breast cancer resistance protein in acute myeloid leukaemia cells treated with the Aurora-B Kinase Inhibitor barasertib-hQPA

    Directory of Open Access Journals (Sweden)

    Russell Nigel H

    2011-06-01

    Full Text Available Abstract Background Aurora kinases play an essential role in orchestrating chromosome alignment, segregation and cytokinesis during mitotic progression, with both aurora-A and B frequently over-expressed in a variety of human malignancies. Over-expression of the ABC drug transporter proteins P-glycoprotein (Pgp and Breast cancer resistance protein (BCRP is a major obstacle for chemotherapy in many tumour types with Pgp conferring particularly poor prognosis in acute myeloid leukaemia (AML. Barasertib-hQPA is a highly selective inhibitor of aurora-B kinase that has shown tumouricidal activity against a range tumour cell lines including those of leukaemic AML origin. Methods Effect of barasertib-hQPA on the pHH3 biomarker and cell viability was measured in a panel of leukaemic cell lines and 37 primary AML samples by flow cytometry. Pgp status was determined by flow cytometry and BCRP status by flow cytometry and real-time PCR. Results In this study we report the creation of the cell line OCI-AML3DNR, which over-expresses Pgp but not BCRP or multidrug resistance-associated protein (MRP, through prolonged treatment of OCI-AML3 cells with daunorubicin. We demonstrate that Pgp (OCI-AML3DNR and KG-1a and BCRP (OCI-AML6.2 expressing AML cell lines are less sensitive to barasertib-hQPA induced pHH3 inhibition and subsequent loss of viability compared to transporter negative cell lines. We also show that barasertib-hQPA resistance in these cell lines can be reversed using known Pgp and BCRP inhibitors. We report that barasertib-hQPA is not an inhibitor of Pgp or BCRP, but by using 14[C]-barasertib-hQPA that it is effluxed by these transporters. Using phosphoHistone H3 (pHH3 as a biomarker of barasertib-hQPA responsiveness in primary AML blasts we determined that Pgp and BCRP positive primary samples were less sensitive to barasertib-hQPA induced pHH3 inhibition (p = 50 inhibition of pHH3 by barasertib-hQPA was achieved in 94.6% of these samples after 1

  6. Longitudinal asymmetries in aurora

    Science.gov (United States)

    Michell, R.; Samara, M.; Grubbs, G. A.

    2013-12-01

    We present a comparative study of auroral structure and dynamics over Poker Flat, Alaska and Tromso, Norway. These stations are at the same geomagnetic latitude but differ significantly (by 4 degrees) in geographic latitude. In the period of 25 November 2012 to 15 March 2013 we have optical imaging data from both stations. There is approximately a 12 hour difference in local time between them and therefore near winter solstice we have simultaneous observations in the dawn and dusk sectors. Differences in auroral morphology, for similar solar wind driving conditions, will be investigated.

  7. Facilities projects performance measurement system

    International Nuclear Information System (INIS)

    The two DOE-owned facilities at Hanford, the Fuels and Materials Examination Facility (FMEF), and the Fusion Materials Irradiation Test Facility (FMIT), are described. The performance measurement systems used at these two facilities are next described

  8. Facility transition instruction

    International Nuclear Information System (INIS)

    The Bechtel Hanford, Inc. facility transition instruction was initiated in response to the need for a common, streamlined process for facility transitions and to capture the knowledge and experience that has accumulated over the last few years. The instruction serves as an educational resource and defines the process for transitioning facilities to long-term surveillance and maintenance (S and M). Generally, these facilities do not have identified operations missions and must be transitioned from operational status to a safe and stable configuration for long-term S and M. The instruction can be applied to a wide range of facilities--from process canyon complexes like the Plutonium Uranium Extraction Facility or B Plant, to stand-alone, lower hazard facilities like the 242B/BL facility. The facility transition process is implemented (under the direction of the US Department of Energy, Richland Operations Office [RL] Assistant Manager-Environmental) by Bechtel Hanford, Inc. management, with input and interaction with the appropriate RL division and Hanford site contractors as noted in the instruction. The application of the steps identified herein and the early participation of all organizations involved are expected to provide a cost-effective, safe, and smooth transition from operational status to deactivation and S and M for a wide range of Hanford Site facilities

  9. Nuclear Physics accelerator facilities

    International Nuclear Information System (INIS)

    The Nuclear Physics program requires the existence and effective operation of large and complex accelerator facilities. These facilities provide the variety of projectile beams upon which virtually all experimental nuclear research depends. Their capability determine which experiments can be performed and which cannot. Seven existing accelerator facilities are operated by the Nuclear Physics program as national facilities. These are made available to all the Nation's scientists on the basis of scientific merit and technical feasibility of proposals. The national facilities are the Clinton P. Anderson Meson Physics Facility (LAMPF) at Los Alamos National Laboratory; the Bates Linear Accelerator Center at Massachusetts Institute of Technology; the Bevalac at Lawrence Berkeley Laboratory; the Tandem/AGS Heavy Ion Facility at Brookhaven National Laboratory; the ATLAS facility at Argonne National Laboratory; the 88-Inch Cyclotron at Lawrence Berkeley Laboratory; the Holifield Heavy Ion Research Facility at Oak Ridge National Laboratory. The Nuclear Physics Injector at the Stanford Linear Accelerator Center (SLAC) enables the SLAC facility to provide a limited amount of beam time for nuclear physics research on the same basis as the other national facilities. To complement the national facilities, the Nuclear Physics program supports on-campus accelerators at Duke University, Texas A and M University, the University of Washington, and Yale University. The facility at Duke University, called the Triangle Universities Nuclear Laboratory (TUNL), is jointly staffed by Duke University, North Carolina State University, and the University of North Carolina. These accelerators are operated primarily for the research use of the local university faculty, junior scientists, and graduate students

  10. Melliferous flora and pollen characterization of honey samples of Apis mellifera L., 1758 in apiaries in the counties of Ubiratã and Nova Aurora, PR.

    Science.gov (United States)

    Sekine, Elizabete S; Toledo, Vagner A A; Caxambu, Marcelo G; Chmura, Suzane; Takashiba, Eliza H; Sereia, Maria Josiane; Marchini, Luís C; Moreti, Augusta C C C

    2013-03-01

    The aim of this study was to carry out a survey of the flora with potential for beekeeping in the counties of Ubiratã and Nova Aurora-PR through the collection of plants and pollen analyses in honey samples collected monthly. 208 species of plants were recorded, distributed in 66 families. The families that showed the major richness of pollen types were: Asteraceae, Myrtaceae and Solanaceae. Approximately 80 pollen types were found in honey samples, most of them were characterized as heterofloral. Cultivated plants, such as Glycine max (soybean) and Eucalyptus spp., were representative in some months of the year. Exotic species, such as Ricinus communis and Melia azedarach, were also frequent. However, over than 50% of the pollen types belong to native species of the region, such as Schinus terebinthifolius, Baccharis spp. Alchornea triplinervia, Parapiptadenia rigida, Hexaclamys edulis, Zanthoxylum sp. and Serjania spp., indicating the importance of the native vegetation for the survival of the colonies. PMID:23460431

  11. New Treatment of Medullary and Papillary Human Thyroid Cancer: Biological Effects of Hyaluronic Acid Hydrogel Loaded With Quercetin Alone or in Combination to an Inhibitor of Aurora Kinase.

    Science.gov (United States)

    Quagliariello, Vincenzo; Armenia, Emilia; Aurilio, Caterina; Rosso, Francesco; Clemente, Ottavia; de Sena, Gabriele; Barbarisi, Manlio; Barbarisi, Alfonso

    2016-08-01

    The aim of this paper is based on the use of a hyaluronic acid hydrogel of Quercetin tested alone and in combination to an inhibitor of Aurora Kinase type A and B (SNS-314) on human medullary and papillary thyroid cancer cells. Biological investigations were focused on the cellular uptake of the hydrogel, cell viability, antioxidant, and cytokines secretion studies. Quercetin delivered from hydrogel show a time and CD44 dependent interaction with both cell lines with significant anti-inflammatory effects. Combination of Quercetin and SNS-314 leads to a synergistic cytotoxic effect on medullary TT and papillary BCPAP cell lines with a significant reduction of the IC50 value. These results, highlights the importance of synergistic effect of the hyaluronic acid hydrogel of Quercetin with SNS-314 in the regulation of human thyroid cancer cell proliferation and emphasize the anti-tumor activity of these molecules. J. Cell. Physiol. 231: 1784-1795, 2016. © 2015 Wiley Periodicals, Inc. PMID:26660542

  12. Content Analysis of Select YouTube Postings: Comparisons of Reactions to the Sandy Hook and Aurora Shootings and Hurricane Sandy.

    Science.gov (United States)

    Miller, Eric D

    2015-11-01

    This study details an innovative and methodical content analysis of 2,207 YouTube comments from four different YouTube videos (e.g., breaking news or memorials) related to the 2012 Sandy Hook Elementary School and Aurora theater mass shootings and the catastrophic Hurricane Sandy. As expected, YouTube comments associated with the Sandy Hook shootings (particularly those from a memorial video) were especially likely to feature compassion and grief with lessened hostility. This study highlights differing online contexts by which individuals show grief and related emotions following man-made and natural calamities and how-even in an online environment-powerful situational contexts greatly guide behavior. PMID:26379103

  13. In vivo FRET imaging revealed a regulatory role of RanGTP in kinetochore-microtubule attachments via Aurora B kinase.

    Directory of Open Access Journals (Sweden)

    Yoke-Peng Lee

    Full Text Available Under the fluctuating circumstances provided by the innate dynamics of microtubules and opposing tensions resulted from microtubule-associated motors, it is vital to ensure stable kinetochore-microtubule attachments for accurate segregation. However, a comprehensive understanding of how this regulation is mechanistically achieved remains elusive. Using our newly designed live cell FRET time-lapse imaging, we found that post-metaphase RanGTP is crucial in the maintenance of stable kinetochore-microtubule attachments by regulating Aurora B kinase via the NES-bearing Mst1. More importantly, our study demonstrates that by ensuring stable alignment of metaphase chromosomes prior to segregation, RanGTP is indispensible in governing the genomic integrity and the fidelity of cell cycle progression. Our findings suggest an additional role of RanGTP beyond its known function in mitotic spindle assembly during the prometaphase-metaphase transition.

  14. El proyecto de rehabilitación frente al método educativo : el caso de la escuela Aurora en Tomiño

    OpenAIRE

    Teixeira Lago, Maria Lorena

    2012-01-01

    Esta investigación pretende que el diálogo entre la arquitectura, la pedagogía y los espacios infantiles se formalice en un caso real: la rehabilitación de la escuela “Aurora del Porvenir”. Ésta se ubica en el ayuntamiento de Tomiño y tiene una gran importancia en la comarca debido a que su construcción fue realizada por una asociación de emigrantes de Río de Janeiro. Buscaban la alfabetización de la población para que ésta pudiera tener oportunidades, por lo que el edificio ti...

  15. 340 Facility compliance assessment

    International Nuclear Information System (INIS)

    This study provides an environmental compliance evaluation of the RLWS and the RPS systems of the 340 Facility. The emphasis of the evaluation centers on compliance with WAC requirements for hazardous and mixed waste facilities, federal regulations, and Westinghouse Hanford Company (WHC) requirements pertinent to the operation of the 340 Facility. The 340 Facility is not covered under either an interim status Part A permit or a RCRA Part B permit. The detailed discussion of compliance deficiencies are summarized in Section 2.0. This includes items of significance that require action to ensure facility compliance with WAC, federal regulations, and WHC requirements. Outstanding issues exist for radioactive airborne effluent sampling and monitoring, radioactive liquid effluent sampling and monitoring, non-radioactive liquid effluent sampling and monitoring, less than 90 day waste storage tanks, and requirements for a permitted facility

  16. Facility effluent monitoring plan determinations for the 400 Area facilities

    International Nuclear Information System (INIS)

    This Facility Effluent Monitoring Plan determination resulted from an evaluation conducted for the Westinghouse Hanford Company 400 Area facilities on the Hanford Site. The Facility Effluent Monitoring Plan determinations have been prepared in accordance with A Guide for Preparing Hanford Site Facility Effluent Monitoring Plans. Two major Westinghouse Hanford Company facilities in the 400 Area were evaluated: the Fast Flux Test Facility and the Fuels Manufacturing and examination Facility. The determinations were prepared by Westinghouse Hanford Company. Of these two facilities, only the Fast Flux Test Facility will require a Facility Effluent Monitoring Plan. 7 refs., 5 figs., 4 tabs

  17. Facility of aerosol filtration

    International Nuclear Information System (INIS)

    Said invention relates to a facility of aerosol filtration, particularly of sodium aerosols. Said facility is of special interest for fast reactors where sodium fires involve the possibility of high concentrations of sodium aerosols which soon clog up conventional filters. The facility intended for continuous operation, includes at the pre-filtering stage, means for increasing the size of the aerosol particles and separating clustered particles (cyclone separator)

  18. Synchrotron radiation facilities

    CERN Multimedia

    1972-01-01

    Particularly in the past few years, interest in using the synchrotron radiation emanating from high energy, circular electron machines has grown considerably. In our February issue we included an article on the synchrotron radiation facility at Frascati. This month we are spreading the net wider — saying something about the properties of the radiation, listing the centres where synchrotron radiation facilities exist, adding a brief description of three of them and mentioning areas of physics in which the facilities are used.

  19. Air gun test facility

    International Nuclear Information System (INIS)

    This paper describes a facility that is potentially useful in providing data for models to predict the effects of nuclear explosions on cities. IIT Research Institute has a large air gun facility capable of launching heavy items of a wide variety of geometries to velocities ranging from about 80 fps to 1100 fps. The facility and its capabilities are described, and city model problem areas capable of investigation using the air gun are presented

  20. Partial pressure (or fugacity) of carbon dioxide, salinity and other variables collected from underway - surface observations using Carbon dioxide (CO2) gas analyzer, Shower head chamber equilibrator for autonomous carbon dioxide (CO2) measurement and other instruments from the AURORA AUSTRALIS in the Indian Ocean, South Pacific Ocean and Tasman Sea from 2011-01-04 to 2011-11-28 (NODC Accession 0115179)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NODC Accession 0115179 includes chemical, meteorological, physical and underway - surface data collected from AURORA AUSTRALIS in the Indian Ocean, South Pacific...

  1. Dissolved inorganic carbon, alkalinity, temperature, salinity and other variables collected from discrete sample and profile observations using Alkalinity titrator, CTD and other instruments from the AURORA AUSTRALIS in the Indian Ocean from 2008-03-22 to 2008-04-17 (NODC Accession 0109900)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NODC Accession 0109900 includes biological, chemical, discrete sample, physical and profile data collected from AURORA AUSTRALIS in the Indian Ocean from 2008-03-22...

  2. Dissolved inorganic carbon, alkalinity, temperature, salinity and other variables collected from discrete sample and profile observations using Alkalinity titrator, CTD and other instruments from the AURORA AUSTRALIS in the Indian Ocean from 2006-01-02 to 2006-03-12 (NODC Accession 0109922)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NODC Accession 0109922 includes biological, chemical, discrete sample, meteorological, physical and profile data collected from AURORA AUSTRALIS in the Indian Ocean...

  3. Partial pressure (or fugacity) of carbon dioxide, salinity and other variables collected from underway - surface observations using Barometric pressure sensor, Carbon dioxide (CO2) gas analyzer and other instruments from the AURORA AUSTRALIS in the Great Australian Bight, Indian Ocean and others from 1992-10-19 to 2001-12-12 (NODC Accession 0115153)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NODC Accession 0115153 includes chemical, meteorological, physical and underway - surface data collected from AURORA AUSTRALIS in the Great Australian Bight, Indian...

  4. Partial pressure (or fugacity) of carbon dioxide, salinity and other variables collected from Surface underway observations using Carbon dioxide (CO2) gas analyzer, Shower head chamber equilibrator for autonomous carbon dioxide (CO2) measurement and other instruments from the AURORA AUSTRALIS in the Indian Ocean, South Pacific Ocean and Tasman Sea from 2013-01-13 to 2013-03-14 (NODC Accession 0117696)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NODC Accession 0117696 includes Surface underway, chemical, meteorological and physical data collected from AURORA AUSTRALIS in the Indian Ocean, South Pacific...

  5. Temperature, salinity and other variables collected from discrete sample and profile observations using CTD, bottle and other instruments from AURORA AUSTRALIS in the Indian Ocean, South Pacific Ocean and Southern Oceans from 2011-01-04 to 2011-02-06 (NCEI Accession 0143947)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NCEI Accession 0143947 includes discrete sample and profile data collected from AURORA AUSTRALIS in the Indian Ocean, South Pacific Ocean and Southern Oceans (>...

  6. Dissolved inorganic carbon, alkalinity, temperature, salinity and other variables collected from discrete sample and profile observations using Alkalinity titrator, CTD and other instruments from AURORA AUSTRALIS in the Indian Ocean and Southern Oceans from 2004-12-23 to 2005-02-17 (NODC Accession 0108076)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NCEI Accession 0108076 includes discrete sample and profile data collected from AURORA AUSTRALIS in the Indian Ocean and Southern Oceans (> 60 degrees South)...

  7. Dissolved inorganic carbon, alkalinity, temperature, salinity and other variables collected from discrete sample and profile observations using Alkalinity titrator, CTD and other instruments from the AURORA AUSTRALIS in the Indian Ocean from 2001-10-29 to 2001-12-13 (NODC Accession 0108158)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NODC Accession 0108158 includes chemical, discrete sample, physical and profile data collected from AURORA AUSTRALIS in the Indian Ocean from 2001-10-29 to...

  8. Temperature, salinity and other variables collected from discrete sample and profile observations using CTD, PAR Sensor and other instruments from AURORA AUSTRALIS in the Indian Ocean and Southern Oceans from 2012-01-05 to 2012-02-12 (NCEI Accession 0143949)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NCEI Accession 0143949 includes discrete sample and profile data collected from AURORA AUSTRALIS in the Indian Ocean and Southern Oceans (> 60 degrees South)...

  9. Dissolved inorganic carbon, alkalinity, temperature, salinity and other variables collected from discrete sample and profile observations using CTD, bottle and other instruments from the AURORA AUSTRALIS in the Great Australian Bight and Indian Ocean from 1998-02-28 to 1998-04-01 (NODC Accession 0115154)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NODC Accession 0115154 includes chemical, discrete sample, physical and profile data collected from AURORA AUSTRALIS in the Great Australian Bight and Indian Ocean...

  10. Dissolved inorganic carbon, temperature, salinity and other variables collected from discrete sample and profile observations using CTD, bottle and other instruments from the AURORA AUSTRALIS in the Indian Ocean, South Pacific Ocean and Tasman Sea from 1993-04-04 to 1993-05-09 (NODC Accession 0115004)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NODC Accession 0115004 includes chemical, discrete sample, physical and profile data collected from AURORA AUSTRALIS in the Indian Ocean, South Pacific Ocean and...

  11. Dissolved inorganic carbon, alkalinity, temperature, salinity and other variables collected from discrete sample and profile observations using CTD, bottle and other instruments from the AURORA AUSTRALIS in the Indian Ocean and South Pacific Ocean from 1994-12-13 to 1995-02-01 (NODC Accession 0115020)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NODC Accession 0115020 includes chemical, discrete sample, physical and profile data collected from AURORA AUSTRALIS in the Indian Ocean and South Pacific Ocean...

  12. Temperature, salinity and other variables collected from discrete sample and profile observations using CTD, bottle and other instruments from AURORA AUSTRALIS in the Indian Ocean and Southern Oceans from 2003-01-03 to 2003-03-17 (NCEI Accession 0143930)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NCEI Accession 0143930 includes discrete sample and profile data collected from AURORA AUSTRALIS in the Indian Ocean and Southern Oceans (> 60 degrees South)...

  13. Temperature, salinity and other variables collected from discrete sample and profile observations using CTD, PAR Sensor and other instruments from AURORA AUSTRALIS in the Indian Ocean, South Pacific Ocean and Southern Oceans from 2007-12-16 to 2008-01-27 (NCEI Accession 0143932)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NCEI Accession 0143932 includes discrete sample and profile data collected from AURORA AUSTRALIS in the Indian Ocean, South Pacific Ocean and Southern Oceans (>...

  14. Target Assembly Facility

    Data.gov (United States)

    Federal Laboratory Consortium — The Target Assembly Facility integrates new armor concepts into actual armored vehicles. Featuring the capability ofmachining and cutting radioactive materials, it...

  15. Materials Characterization Facility

    Data.gov (United States)

    Federal Laboratory Consortium — The Materials Characterization Facility enables detailed measurements of the properties of ceramics, polymers, glasses, and composites. It features instrumentation...

  16. High Combustion Research Facility

    Data.gov (United States)

    Federal Laboratory Consortium — At NETL's High-Pressure Combustion Research Facility in Morgantown, WV, researchers can investigate new high-pressure, high-temperature hydrogen turbine combustion...

  17. DUPIC facility engineering

    Energy Technology Data Exchange (ETDEWEB)

    Park, J. J.; Lee, H. H.; Kim, K. H. and others

    2000-03-01

    The objectives of this study are (1) the refurbishment for PIEF(Post Irradiation Examination Facility) and M6 hot-cell in IMEF(Irradiated Material Examination Facility), (2) the establishment of the compatible facility for DUPIC fuel fabrication experiments which is licensed by government organization, and (3) the establishment of the transportation system and transportation cask for nuclear material between facilities. The report for this project describes following contents, such as objectives, necessities, scope, contents, results of current step, R and D plan in future and etc.

  18. Textiles Performance Testing Facilities

    Data.gov (United States)

    Federal Laboratory Consortium — The Textiles Performance Testing Facilities has the capabilities to perform all physical wet and dry performance testing, and visual and instrumental color analysis...

  19. Manufacturing Demonstration Facility (MDF)

    Data.gov (United States)

    Federal Laboratory Consortium — The U.S. Department of Energy Manufacturing Demonstration Facility (MDF) at Oak Ridge National Laboratory (ORNL) provides a collaborative, shared infrastructure to...

  20. GPS Test Facility

    Data.gov (United States)

    Federal Laboratory Consortium — The Global Positioning System (GPS) Test Facility Instrumentation Suite (GPSIS) provides great flexibility in testing receivers by providing operational control of...

  1. Composite Structures Manufacturing Facility

    Data.gov (United States)

    Federal Laboratory Consortium — The Composite Structures Manufacturing Facility specializes in the design, analysis, fabrication and testing of advanced composite structures and materials for both...

  2. Proximal Probes Facility

    Data.gov (United States)

    Federal Laboratory Consortium — The Proximal Probes Facility consists of laboratories for microscopy, spectroscopy, and probing of nanostructured materials and their functional properties. At the...

  3. DUPIC facility engineering

    International Nuclear Information System (INIS)

    The objectives of this study are 1) the refurbishment for PIEF(Post Irradiation Examination Facility) and M6 hot-cell in IMEF(Irradiated Material Examination Facility), 2) the establishment of the compatible facility for DUPIC fuel fabrication experiments which is licensed by government organization, and 3) the establishment of the transportation system and transportation cask for nuclear material between facilities. The report for this project describes following contents, such as objectives, necessities, scope, contents, results of current step, R and D plan in future and etc

  4. Region 9 NPDES Facilities

    Data.gov (United States)

    U.S. Environmental Protection Agency — Point geospatial dataset representing locations of NPDES Facilities. NPDES (National Pollution Discharge Elimination System) is an EPA permit program that regulates...

  5. Universal Drive Train Facility

    Data.gov (United States)

    Federal Laboratory Consortium — This vehicle drive train research facility is capable of evaluating helicopter and ground vehicle power transmission technologies in a system level environment. The...

  6. Pavement Testing Facility

    Data.gov (United States)

    Federal Laboratory Consortium — Comprehensive Environmental and Structural Analyses The ERDC Pavement Testing Facility, located on the ERDC Vicksburg campus, was originally constructed to provide...

  7. Joint Computing Facility

    Data.gov (United States)

    Federal Laboratory Consortium — Raised Floor Computer Space for High Performance Computing The ERDC Information Technology Laboratory (ITL) provides a robust system of IT facilities to develop and...

  8. Neutron Therapy Facility

    Data.gov (United States)

    Federal Laboratory Consortium — The Neutron Therapy Facility provides a moderate intensity, broad energy spectrum neutron beam that can be used for short term irradiations for radiobiology (cells)...

  9. Geodynamics Research Facility

    Data.gov (United States)

    Federal Laboratory Consortium — This GSL facility has evolved over the last three decades to support survivability and protective structures research. Experimental devices include three gas-driven...

  10. Florida Educational Facilities, 1999.

    Science.gov (United States)

    Florida State Dept. of Education, Tallahassee. Office of Educational Facilities.

    This publication describes Florida school and community college facilities completed in 1999, including photographs and floor plans. The facilities profiled are: Buchholz High School (Alachua County); Gator Run Elementary School (Broward); Corkscrew Elementary School (Collier); The 500 Role Models Academy of Excellence (Miami-Dade); Caribbean…

  11. Science Facilities Bibliography.

    Science.gov (United States)

    National Science Foundation, Washington, DC.

    A bibliographic collection on science buildings and facilities is cited with many different reference sources for those concerned with the design, planning, and layout of science facilities. References are given covering a broad scope of information on--(1) physical plant planning, (2) management and safety, (3) building type studies, (4) design…

  12. Medical cyclotron facilities

    International Nuclear Information System (INIS)

    This report examines the separate proposals from the Austin Hospital and the Australian Atomic Energy Commission for a medical cyclotron facility. The proponents have argued that a cyclotron facility would benefit Australia in areas of patient care, availability and export of radioisotopes, and medical research. Positron emission tomography (PET) and neutron beam therapy are also examined

  13. Bevalac biomedical facility

    International Nuclear Information System (INIS)

    This paper describes the physical layout of the Bevalac Facility and the research programs carried out at the facility. Beam time on the Bevalac is divided between two disciplines: one-third for biomedical research and two-thirds for nuclear science studies. The remainder of the paper discusses the beam delivery system including dosimetry, beam sharing and beam scanning

  14. FACILITIES FOR PHYSICAL FITNESS.

    Science.gov (United States)

    MUSIAL, STAN

    THIS ARTICLE CITES THE LOW PRIORITY THAT PHYSICAL EDUCATION GENERALLY HAS IN CURRICULUM AND SCHOOL FACILITY PLANNING. IT ALSO CITES THE REASONS FOR DEVELOPING MORE ADEQUATE PHYSICAL EDUCATION FACILITIES--(1) OUR WAY OF LIFE NO LONGER PROVIDES VIGOROUS PHYSICAL ACTIVITY NECESSARY FOR HEALTHY DEVELOPMENT, (2) A DIRECT RELATIONSHIP EXISTS BETWEEN…

  15. Grout treatment facility operation

    International Nuclear Information System (INIS)

    This paper summarizes the operation of the Grout Treatment Facility from initial testing to the final disposal to date of 3.8 x 103 m3 (1 Mgal) of low-level radioactive waste. It describes actual component testing and verification, testing of the full-scale system with simulated waste feed, summary of the radioactive disposal operation, lessons learned and equipment performance summary, facility impacts from safety analyses, long-term performance assessments, the Part B application, and projected facility modifications. The Grout Treatment Facility is one of two operations for permanently disposing of liquid defense wastes at the Hanford site near Richland, Washington, for the U.S. Department of Energy. High- and low-level radioactive wastes have been accumulating from defense material production since the mid-1940s at the Hanford site. All radioactive low-level and low-level mixed liquid wastes will be disposed of at the future Hanford Vitrification Facility

  16. Nuclear physics accelerator facilities

    International Nuclear Information System (INIS)

    This paper describes many of the nuclear physics heavy-ion accelerator facilities in the US and the research programs being conducted. The accelerators described are: Argonne National Laboratory--ATLAS; Brookhaven National Laboratory--Tandem/AGS Heavy Ion Facility; Brookhaven National Laboratory--Relativistic Heavy Ion Collider (RHIC) (Proposed); Continuous Electron Beam Accelerator Facility; Lawrence Berkeley Laboratory--Bevalac; Lawrence Berkeley Laboratory--88-Inch Cyclotron; Los Alamos National Laboratory--Clinton P. Anderson Meson Physics Facility (LAMPF); Massachusetts Institute of Technology--Bates Linear Accelerator Center; Oak Ridge National Laboratory--Holifield Heavy Ion Research Facility; Oak Ridge National Laboratory--Oak Ridge Electron Linear Accelerator; Stanford Linear Accelerator Center--Nuclear Physics Injector; Texas AandM University--Texas AandM Cyclotron; Triangle Universities Nuclear Laboratory (TUNL); University of Washington--Tandem/Superconducting Booster; and Yale University--Tandem Van de Graaff

  17. Reactor coolant cleanup facility

    International Nuclear Information System (INIS)

    A depressurization device is disposed in pipelines upstream of recycling pumps of a reactor coolant cleanup facility to reduce a pressure between the pressurization device and the recycling pump at the downstream, thereby enabling high pressure coolant injection from other systems by way of the recycling pumps. Upon emergency, the recycling pumps of the coolant cleanup facility can be used in common to an emergency reactor core cooling facility and a reactor shutdown facility. Since existent pumps of the emergency reactor core cooling facility and the reactor shutdown facility which are usually in a stand-by state can be removed, operation confirmation test and maintenance for equipments in both of facilities can be saved, so that maintenance and reliability of the plant are improved and burdens on operators can also be mitigated. Moreover, low pressure design can be adopted for a non-regenerative heat exchanger and recycling coolant pumps, which enables to improve the reliability and economical property due to reduction of possibility of leakage. (N.H.)

  18. DUPIC facility engineering

    International Nuclear Information System (INIS)

    In the early stage of the project, a comprehensive survey was conducted to identify the feasibility of using available facilities and of interface between those facilities. It was found out that the shielded cell M6 interface between those facilities. It was found out that the shielded cell M6 of IMEF could be used for the main process experiments of DUPIC fuel fabrication in regard to space adequacy, material flow, equipment layout, etc. Based on such examination, a suitable adapter system for material transfer around the M6 cell was engineered. Regarding the PIEF facility, where spent PWR fuel assemblies are stored in an annex pool, disassembly devices in the pool are retrofitted and spent fuel rod cutting and shipping system to the IMEF are designed and built. For acquisition of casks for radioactive material transport between the facilities, some adaptive refurbishment was applied to the available cask (Padirac) based on extensive analysis on safety requirements. A mockup test facility was newly acquired for remote test of DUPIC fuel fabrication process equipment prior to installation in the M6 cell of the IMEF facility. (author). 157 refs., 57 tabs., 65 figs

  19. DUPIC facility engineering

    Energy Technology Data Exchange (ETDEWEB)

    Lee, J. S.; Choi, J. W.; Go, W. I.; Kim, H. D.; Song, K. C.; Jeong, I. H.; Park, H. S.; Im, C. S.; Lee, H. M.; Moon, K. H.; Hong, K. P.; Lee, K. S.; Suh, K. S.; Kim, E. K.; Min, D. K.; Lee, J. C.; Chun, Y. B.; Paik, S. Y.; Lee, E. P.; Yoo, G. S.; Kim, Y. S.; Park, J. C.

    1997-09-01

    In the early stage of the project, a comprehensive survey was conducted to identify the feasibility of using available facilities and of interface between those facilities. It was found out that the shielded cell M6 interface between those facilities. It was found out that the shielded cell M6 of IMEF could be used for the main process experiments of DUPIC fuel fabrication in regard to space adequacy, material flow, equipment layout, etc. Based on such examination, a suitable adapter system for material transfer around the M6 cell was engineered. Regarding the PIEF facility, where spent PWR fuel assemblies are stored in an annex pool, disassembly devices in the pool are retrofitted and spent fuel rod cutting and shipping system to the IMEF are designed and built. For acquisition of casks for radioactive material transport between the facilities, some adaptive refurbishment was applied to the available cask (Padirac) based on extensive analysis on safety requirements. A mockup test facility was newly acquired for remote test of DUPIC fuel fabrication process equipment prior to installation in the M6 cell of the IMEF facility. (author). 157 refs., 57 tabs., 65 figs.

  20. Biotechnology Facility: An ISS Microgravity Research Facility

    Science.gov (United States)

    Gonda, Steve R.; Tsao, Yow-Min

    2000-01-01

    The International Space Station (ISS) will support several facilities dedicated to scientific research. One such facility, the Biotechnology Facility (BTF), is sponsored by the Microgravity Sciences and Applications Division (MSAD) and developed at NASA's Johnson Space Center. The BTF is scheduled for delivery to the ISS via Space Shuttle in April 2005. The purpose of the BTF is to provide: (1) the support structure and integration capabilities for the individual modules in which biotechnology experiments will be performed, (2) the capability for human-tended, repetitive, long-duration biotechnology experiments, and (3) opportunities to perform repetitive experiments in a short period by allowing continuous access to microgravity. The MSAD has identified cell culture and tissue engineering, protein crystal growth, and fundamentals of biotechnology as areas that contain promising opportunities for significant advancements through low-gravity experiments. The focus of this coordinated ground- and space-based research program is the use of the low-gravity environment of space to conduct fundamental investigations leading to major advances in the understanding of basic and applied biotechnology. Results from planned investigations can be used in applications ranging from rational drug design and testing, cancer diagnosis and treatments and tissue engineering leading to replacement tissues.

  1. Exploring the Habitability of Ice-covered Waterworlds: The Deep-Sea Hydrothermal System of the Aurora Mount at Gakkel Ridge, Arctic Ocean (82°54' N, 6°15W, 3900 m)

    Science.gov (United States)

    Boetius, A.; Bach, W.; Borowski, C.; Diehl, A.; German, C. R.; Kaul, N. E.; Koehler, J.; Marcon, Y.; Mertens, C.; Molari, M.; Schlindwein, V. S. N.; Tuerke, A.; Wegener, G.

    2014-12-01

    The geographic remoteness of the ultraslow Gakkel Ridge in the ice-covered Arctic Ocean raises many questions about the nature and biogeography of its habitats. In 2001, the two-ice-breaker mission AMORE (RV POLARSTERN and USCGC HEALY) detected hydrothermal plumes and evidence for seafloor venting associated with volcanic ridges rising from the rift valley floor of 4.2 km depth (Edmonds et al., 2003; Michael et al., 2003). The AURORA expedition in July 2014 (RV POLARSTERN Cruise PS86) targeted this "Aurora" field at the SW limit of Gakkel Ridge, to investigate its habitats, communities and their energy sources. No robots can yet be deployed through ice-cover to explore such deep habitats and ice-breaking research vessels cannot hold position in the thick multiyear ice. Instead, we estimated ice-drift to predict suitable start positions, then attached POLARSTERN to a matching ice floe, to achieve the bottom trajectories that we required for targeted exploration. The Aurora mount is volcanic in origin formed from mounded pillow basalts overlain by about a meter of sediment and cut through by steep cliffs revealing basalt pillows in outcrop and in talus piles. We identified persistent plume activity in the water column above the mount at 3100-3600 m (800-300 m off-bottom of its top) characterized by anomalies in turbidity, Eh, methane, temperature, density, and elevated microbial chemoautotrophic activity. Using a towed camera-, and multisensor- platform (OFOS) we located active venting as the source of this plume together with inactive chimneys and associated craters on the SW flank of Mt.Aurora. Its dominantly filter-feeding fauna is apparently sustained by venting of energy-rich fluids and microbial transfer of this geofuel into nutrition. This communication presents first results of our recent fieldwork and experimental investigations in Summer 2014 to explore deep-sea ecosystems in ice-covered oceans.

  2. Sustainable Facilities Management

    DEFF Research Database (Denmark)

    Nielsen, Susanne Balslev; Elle, Morten; Hoffmann, Birgitte; Jensen, Jesper Ole

    The Danish public housing sector has more than 20 years of experience with sustainable facilities management based on user involvement. The paper outlines this development in a historical perspective and gives an analysis of different approaches to sustainable facilities management. The focus is on...... the housing departments and strateies for the management of the use of resources. The research methods used are case studies based on interviews in addition to literature studies. The paper explores lessons to be learned about sustainable facilities management in general, and points to a need for new...

  3. Sustainable Facilities Management

    DEFF Research Database (Denmark)

    Nielsen, Susanne Balslev; Elle, Morten; Hoffmann, Birgitte;

    2004-01-01

    the housing departments and strateies for the management of the use of resources. The research methods used are case studies based on interviews in addition to literature studies. The paper explores lessons to be learned about sustainable facilities management in general, and points to a need for new......The Danish public housing sector has more than 20 years of experience with sustainable facilities management based on user involvement. The paper outlines this development in a historical perspective and gives an analysis of different approaches to sustainable facilities management. The focus is on...

  4. Metal-smelting facility

    International Nuclear Information System (INIS)

    Currently there are 90,000 tons of contaminated ferrous and nonferrous scrap metal stored in aboveground scrap yards at the Department of Energy's Uranium Enrichment Facilities in Tennessee, Kentucky, and Ohio. This scrap is primarily contaminated with 100 to 500 ppM uranium at an average enrichment of 1 to 1.5% 235U. A study was performed that evaluated smelting of the ORGDP metal in a reference facility located at Oak Ridge. The study defined the process systems and baseline requirements, evaluated alternatives to smelting, and provided capital and operating costs for the reference facility. A review of the results and recommendations of this study are presented

  5. Environmental Test Facility (ETF)

    Data.gov (United States)

    Federal Laboratory Consortium — The Environmental Test Facility (ETF) provides non-isolated shock testing for stand-alone equipment and full size cabinets under MIL-S-901D specifications. The ETF...

  6. GPS Satellite Simulation Facility

    Data.gov (United States)

    Federal Laboratory Consortium — The GPS satellite simulation facility consists of a GPS satellite simulator controlled by either a Silicon Graphics Origin 2000 or PC depending upon unit under test...

  7. Frost Effects Research Facility

    Data.gov (United States)

    Federal Laboratory Consortium — Full-scale study in controlled conditions The Frost Effects Research Facility (FERF) is the largest refrigerated warehouse in the United States that can be used for...

  8. The Birmingham Irradiation Facility

    International Nuclear Information System (INIS)

    At the end of 2012 the proton irradiation facility at the CERN PS will shut down for two years. With this in mind, we have been developing a new ATLAS scanning facility at the University of Birmingham Medical Physics cyclotron. With proton beams of energy approximately 30 MeV, fluences corresponding to those of the upgraded Large Hadron Collider (HL-LHC) can be reached conveniently. The facility can be used to irradiate silicon sensors, optical components and mechanical structures (e.g. carbon fibre sandwiches) for the LHC upgrade programme. Irradiations of silicon sensors can be carried out in a temperature controlled cold box that can be scanned through the beam. The facility is described in detail along with the first tests carried out with mini (1×1 cm2) silicon sensors

  9. Mark 1 Test Facility

    Data.gov (United States)

    Federal Laboratory Consortium — The Mark I Test Facility is a state-of-the-art space environment simulation test chamber for full-scale space systems testing. A $1.5M dollar upgrade in fiscal year...

  10. Structural Test Facility

    Data.gov (United States)

    Federal Laboratory Consortium — Provides a wide variety of testing equipment, fixtures and facilities to perform both unique aviation component testing as well as common types of materials testing...

  11. Healthcare Facility Locations

    Data.gov (United States)

    U.S. Department of Health & Human Services — MAP:http://tinyurl.com/HealthcareFacilityLocationsMap The California Department of Public Health (CDPH), Center for Health Care Quality, Licensing and Certification...

  12. FDA Certified Mammography Facilities

    Science.gov (United States)

    ... Products Radiation-Emitting Products Home Radiation-Emitting Products Mammography Quality Standards Act and Program Consumer Information (MQSA) ... it Email Print This list of FDA Certified Mammography Facilities is updated weekly. If you click on ...

  13. Laser Guidance Analysis Facility

    Data.gov (United States)

    Federal Laboratory Consortium — This facility, which provides for real time, closed loop evaluation of semi-active laser guidance hardware, has and continues to be instrumental in the development...

  14. Water Tunnel Facility

    Data.gov (United States)

    Federal Laboratory Consortium — NETL’s High-Pressure Water Tunnel Facility in Pittsburgh, PA, re-creates the conditions found 3,000 meters beneath the ocean’s surface, allowing scientists to study...

  15. Liquid Effluent Retention Facility

    Data.gov (United States)

    Federal Laboratory Consortium — The Liquid Effluent Retention Facility (LERF) is located in the central part of the Hanford Site. LERF is permitted by the State of Washington and has three liquid...

  16. Decontamination of nuclear facilities

    International Nuclear Information System (INIS)

    Thirty-seven papers were presented at this conference in five sessions. Topics covered include regulation, control and consequences of decontamination; decontamination of components and facilities; chemical and non-chemical methods of decontamination; and TMI decontamination experience

  17. Robotics Research Facility

    Data.gov (United States)

    Federal Laboratory Consortium — This 60 feet x 100 feet structure on the grounds of the Fort Indiantown Gap Pennsylvania National Guard (PNG) Base is a mixed-use facility comprising office space,...

  18. FacilitiesSchools_PTSCHOOL

    Data.gov (United States)

    Vermont Center for Geographic Information — FacilitiesSchools_PTSCHOOL is designed to provide point locations of every Vermont School along with the established school ID (PSID) for geographic analysis of...

  19. Skilled Nursing Facility PPS

    Data.gov (United States)

    U.S. Department of Health & Human Services — Section 4432(a) of the Balanced Budget Act (BBA) of 1997 modified how payment is made for Medicare skilled nursing facility (SNF) services. Effective with cost...

  20. The Birmingham Irradiation Facility

    CERN Document Server

    Dervan, P; Hodgson, P; Marin-Reyes, H; Wilson, J

    2013-01-01

    At the end of 2012 the proton irradiation facility at the CERN PS [1] will shut down for two years. With this in mind, we have been developing a new ATLAS scanning facility at the University of Birmingham Medical Physics cyclotron. With proton beams of energy approximately 30 MeV, fluences corresponding to those of the upgraded Large Hadron Collider (HL-LHC) can be reached conveniently. The facility can be used to irradiate silicon sensors, optical components and mechanical structures (e.g. carbon fibre sandwiches) for the LHC upgrade programme. Irradiations of silicon sensors can be carried out in a temperature controlled cold box that can be scanned through the beam. The facility is described in detail along with the first tests carried out with mini (1 x 1 cm^2 ) silicon sensors.

  1. Combustion Research Facility

    Data.gov (United States)

    Federal Laboratory Consortium — For more than 30 years The Combustion Research Facility (CRF) has served as a national and international leader in combustion science and technology. The need for a...

  2. Electra Laser Facility

    Data.gov (United States)

    Federal Laboratory Consortium — FUNCTION: The Electra Laser Facility is used to develop the science and technology needed to develop a reliable, efficient, high-energy, repetitively pulsed krypton...

  3. Dialysis Facility Compare Data

    Data.gov (United States)

    U.S. Department of Health & Human Services — These are the official datasets used on the Medicare.gov Dialysis Facility Compare Website provided by the Centers for Medicare and Medicaid Services. These data...

  4. Photovoltaic systems test facility

    Science.gov (United States)

    1979-01-01

    Facility provides broad and flexible capability for evaluating photovoltaic systems and design concepts. As 'breadboard' system, it can be used to check out complete systems, subsystems, and components before installation in actual service.

  5. Ballistic Test Facility

    Data.gov (United States)

    Federal Laboratory Consortium — The Ballistic Test Facility is comprised of two outdoor and one indoor test ranges, which are all instrumented for data acquisition and analysis. Full-size aircraft...

  6. College/University Facilities.

    Science.gov (United States)

    Athletic Business, 2002

    2002-01-01

    Describes the building designs of 117 state-of-the-art of college athletic and recreational facilities, including the educational contexts and design goals. Includes information on architects and designers, construction cost, size, and occupancy date. Also provides photographs. (EV)

  7. Indoor Ground Ejection Facility

    Data.gov (United States)

    Federal Laboratory Consortium — This climate controlled facility is used to evaluate air stores and equipment to determine ejection velocities, store pitch rates, and arming wire and device system...

  8. Pittsburgh City Facilities

    Data.gov (United States)

    Allegheny County / City of Pittsburgh / Western PA Regional Data Center — Pittsburgh City FacilitiesIncludes: City Administrative Buildings, Police Stations, Fire Stations, EMS Stations, DPW Sites, Senior Centers, Recreation Centers,...

  9. Advanced Microscopy Facility

    Data.gov (United States)

    Federal Laboratory Consortium — FUNCTION: Provides a facility for high-resolution studies of complex biomolecular systems. The goal is an understanding of how to engineer biomolecules for various...

  10. Coastal Inlet Model Facility

    Data.gov (United States)

    Federal Laboratory Consortium — The Coastal Inlet Model Facility, as part of the Coastal Inlets Research Program (CIRP), is an idealized inlet dedicated to the study of coastal inlets and equipped...

  11. Wind Tunnel Testing Facilities

    Data.gov (United States)

    Federal Laboratory Consortium — NASA Ames Research Center is pleased to offer the services of our premier wind tunnel facilities that have a broad range of proven testing capabilities to customers...

  12. Hypersonic Tunnel Facility (HTF)

    Data.gov (United States)

    Federal Laboratory Consortium — The Hypersonic Tunnel Facility (HTF) is a blow-down, non-vitiated (clean air) free-jet wind tunnel capable of testing large-scale, propulsion systems at Mach 5, 6,...

  13. Air Data Calibration Facility

    Data.gov (United States)

    Federal Laboratory Consortium — This facility is for low altitude subsonic altimeter system calibrations of air vehicles. Mission is a direct support of the AFFTC mission. Postflight data merge is...

  14. Skilled nursing or rehabilitation facilities

    Science.gov (United States)

    ... page: //medlineplus.gov/ency/patientinstructions/000435.htm Skilled nursing or rehabilitation facilities To use the sharing features ... facility. Who Needs to go to a Skilled Nursing or Rehabilitation Facility? Your health care provider may ...

  15. National Solar Thermal Test Facility

    Data.gov (United States)

    Federal Laboratory Consortium — The National Solar Thermal Test Facility (NSTTF) is the only test facility in the United States of its type. This unique facility provides experimental engineering...

  16. Design of Children Entertainment Facilities

    OpenAIRE

    Mei Li

    2009-01-01

    In this paper, mainly through analysis of problems on existing children entertainment facilities and the impact of children entertainment facilities on children psychological development, it is to be discussed about the key point of children entertainment facilities design.

  17. Hydrography - Water Pollution Control Facilities

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — A Water Pollution Control Facility is a DEP primary facility type related to the Water Pollution Control Program. The sub-facility types related to Water Pollution...

  18. Auditing radiation sterilization facilities

    International Nuclear Information System (INIS)

    The diversity of radiation sterilization systems available today places renewed emphasis on the need for thorough Quality Assurance audits of these facilities. Evaluating compliance with Good Manufacturing Practices is an obvious requirement, but an effective audit must also evaluate installation and performance qualification programs (validation), and process control and monitoring procedures in detail. The present paper describes general standards that radiation sterilization operations should meet in each of these key areas, and provides basic guidance for conducting QA audits of these facilities. (author)

  19. Nuclear physics accelerator facilities

    International Nuclear Information System (INIS)

    Brief descriptions are given of DOE and Nuclear Physics program operated and sponsored accelerator facilities. Specific facilities covered are the Argonne Tandem/Linac Accelerator System, the Tandem/AGS Heavy Ion Facility at Brookhaven National Laboratory, the proposed Continuous Beam Accelerator at Newport News, Virginia, the Triangle Universities Nuclear Laboratory at Duke University, the Bevalac and the SuperHILAC at Lawrence Berkeley Laboratory, the 88-Inch Cyclotron at Lawrence Berkeley Laboratory, the Clinton P. Anderson Meson Physics Facility at Los Alamos National Laboratory, the Bates Linear Accelerator Center at Massachusetts Institute of Technology, the Holifield Heavy Ion Research Facility at Oak Ridge National Laboratory, the Nuclear Physics Injector at Stanford Linear Accelerator Center, the Texas A and M Cyclotrons, the Tandem/Superconducting Booster Accelerator at the University of Washington and the Tandem Van de Graaff at the A.W. Wright Nuclear Structure Laboratory of Yale University. Included are acquisition cost, research programs, program accomplishments, future directions, and operating parameters of each facility

  20. The CUTLASS database facilities

    International Nuclear Information System (INIS)

    The enhancement of the CUTLASS database management system to provide improved facilities for data handling is seen as a prerequisite to its effective use for future power station data processing and control applications. This particularly applies to the larger projects such as AGR data processing system refurbishments, and the data processing systems required for the new Coal Fired Reference Design stations. In anticipation of the need for improved data handling facilities in CUTLASS, the CEGB established a User Sub-Group in the early 1980's to define the database facilities required by users. Following the endorsement of the resulting specification and a detailed design study, the database facilities have been implemented as an integral part of the CUTLASS system. This paper provides an introduction to the range of CUTLASS Database facilities, and emphasises the role of Database as the central facility around which future Kit 1 and (particularly) Kit 6 CUTLASS based data processing and control systems will be designed and implemented. (author)

  1. Mound facility physical characterization

    Energy Technology Data Exchange (ETDEWEB)

    Tonne, W.R.; Alexander, B.M.; Cage, M.R.; Hase, E.H.; Schmidt, M.J.; Schneider, J.E.; Slusher, W.; Todd, J.E.

    1993-12-01

    The purpose of this report is to provide a baseline physical characterization of Mound`s facilities as of September 1993. The baseline characterizations are to be used in the development of long-term future use strategy development for the Mound site. This document describes the current missions and alternative future use scenarios for each building. Current mission descriptions cover facility capabilities, physical resources required to support operations, current safety envelope and current status of facilities. Future use scenarios identify potential alternative future uses, facility modifications required for likely use, facility modifications of other uses, changes to safety envelope for the likely use, cleanup criteria for each future use scenario, and disposition of surplus equipment. This Introductory Chapter includes an Executive Summary that contains narrative on the Functional Unit Material Condition, Current Facility Status, Listing of Buildings, Space Plans, Summary of Maintenance Program and Repair Backlog, Environmental Restoration, and Decontamination and Decommissioning Programs. Under Section B, Site Description, is a brief listing of the Site PS Development, as well as Current Utility Sources. Section C contains Site Assumptions. A Maintenance Program Overview, as well as Current Deficiencies, is contained within the Maintenance Program Chapter.

  2. Advanced reactor experimental facilities

    International Nuclear Information System (INIS)

    For many years, the NEA has been examining advanced reactor issues and disseminating information of use to regulators, designers and researchers on safety issues and research needed. Following the recommendation of participants at an NEA workshop, a Task Group on Advanced Reactor Experimental Facilities (TAREF) was initiated with the aim of providing an overview of facilities suitable for carrying out the safety research considered necessary for gas-cooled reactors (GCRs) and sodium fast reactors (SFRs), with other reactor systems possibly being considered in a subsequent phase. The TAREF was thus created in 2008 with the following participating countries: Canada, the Czech Republic, Finland, France, Germany, Hungary, Italy, Japan, Korea and the United States. In a second stage, India provided valuable information on its experimental facilities related to SFR safety research. The study method adopted entailed first identifying high-priority safety issues that require research and then categorizing the available facilities in terms of their ability to address the safety issues. For each of the technical areas, the task members agreed on a set of safety issues requiring research and established a ranking with regard to safety relevance (high, medium, low) and the status of knowledge based on the following scale relative to full knowledge: high (100%-75%), medium (75 - 25%) and low (25-0%). Only the issues identified as being of high safety relevance and for which the state of knowledge is low or medium were included in the discussion, as these issues would likely warrant further study. For each of the safety issues, the TAREF members identified appropriate facilities, providing relevant information such as operating conditions (in- or out-of reactor), operating range, description of the test section, type of testing, instrumentation, current status and availability, and uniqueness. Based on the information collected, the task members assessed prospects and priorities

  3. Facility Environmental Vulnerability Assessment

    International Nuclear Information System (INIS)

    From mid-April through the end of June 2001, a Facility Environmental Vulnerability Assessment (FEVA) was performed at Oak Ridge National Laboratory (ORNL). The primary goal of this FEVA was to establish an environmental vulnerability baseline at ORNL that could be used to support the Laboratory planning process and place environmental vulnerabilities in perspective. The information developed during the FEVA was intended to provide the basis for management to initiate immediate, near-term, and long-term actions to respond to the identified vulnerabilities. It was expected that further evaluation of the vulnerabilities identified during the FEVA could be carried out to support a more quantitative characterization of the sources, evaluation of contaminant pathways, and definition of risks. The FEVA was modeled after the Battelle-supported response to the problems identified at the High Flux Beam Reactor at Brookhaven National Laboratory. This FEVA report satisfies Corrective Action 3A1 contained in the Corrective Action Plan in Response to Independent Review of the High Flux Isotope Reactor Tritium Leak at the Oak Ridge National Laboratory, submitted to the Department of Energy (DOE) ORNL Site Office Manager on April 16, 2001. This assessment successfully achieved its primary goal as defined by Laboratory management. The assessment team was able to develop information about sources and pathway analyses although the following factors impacted the team's ability to provide additional quantitative information: the complexity and scope of the facilities, infrastructure, and programs; the significantly degraded physical condition of the facilities and infrastructure; the large number of known environmental vulnerabilities; the scope of legacy contamination issues [not currently addressed in the Environmental Management (EM) Program]; the lack of facility process and environmental pathway analysis performed by the accountable line management or facility owner; and poor

  4. Facility Environmental Vulnerability Assessment

    Energy Technology Data Exchange (ETDEWEB)

    Van Hoesen, S.D.

    2001-07-09

    From mid-April through the end of June 2001, a Facility Environmental Vulnerability Assessment (FEVA) was performed at Oak Ridge National Laboratory (ORNL). The primary goal of this FEVA was to establish an environmental vulnerability baseline at ORNL that could be used to support the Laboratory planning process and place environmental vulnerabilities in perspective. The information developed during the FEVA was intended to provide the basis for management to initiate immediate, near-term, and long-term actions to respond to the identified vulnerabilities. It was expected that further evaluation of the vulnerabilities identified during the FEVA could be carried out to support a more quantitative characterization of the sources, evaluation of contaminant pathways, and definition of risks. The FEVA was modeled after the Battelle-supported response to the problems identified at the High Flux Beam Reactor at Brookhaven National Laboratory. This FEVA report satisfies Corrective Action 3A1 contained in the Corrective Action Plan in Response to Independent Review of the High Flux Isotope Reactor Tritium Leak at the Oak Ridge National Laboratory, submitted to the Department of Energy (DOE) ORNL Site Office Manager on April 16, 2001. This assessment successfully achieved its primary goal as defined by Laboratory management. The assessment team was able to develop information about sources and pathway analyses although the following factors impacted the team's ability to provide additional quantitative information: the complexity and scope of the facilities, infrastructure, and programs; the significantly degraded physical condition of the facilities and infrastructure; the large number of known environmental vulnerabilities; the scope of legacy contamination issues [not currently addressed in the Environmental Management (EM) Program]; the lack of facility process and environmental pathway analysis performed by the accountable line management or facility owner; and

  5. Baseline non-traditional resource use in the Aurora Mine EIA local study area and the Syncrude/Suncor regional study area

    International Nuclear Information System (INIS)

    As part of the environmental impact assessment (EIA) in the regional and local study area of Syncrude's proposed Aurora Mine, the use of natural resources by non-aboriginal residents and non-residents in the area was documented. The objective of the study was to determine what specific resources are being used, how much, when, where and why. The topics included hunting, fishing, camping and canoeing. Public opinion regarding opportunities for resource use was also documented. The report focused on the dynamic nature of resource use, secondary economies (tourist accommodations) and quality of life. A telephone survey was conducted in which 17 respondents from recreational organizations answered a resource use questionnaire which contained 38 questions on consumptive and non-consumptive uses of wildlife, fish, berries, timber, non-resident use and resource management policies. The three environmentally significant areas of the local study area included the Muskeg River, Kearl Lake and East Jackpine Creek. The regional study are contained the Horse River Diversity area, La Saline Natural area, Schultz's Bog Diversity area, Athabasca Tar Sands Reach, Clearwater River, McClelland Lake Patterned Fens, McClelland Lake, and the Fort Hills. Agriculture in both areas is limited because of unfavourable climate and generally low-quality soil. 13 refs., 7 tabs., 6 figs

  6. A phase I trial of the aurora kinase inhibitor, ENMD-2076, in patients with relapsed or refractory acute myeloid leukemia or chronic myelomonocytic leukemia.

    Science.gov (United States)

    Yee, Karen W L; Chen, Hsiao-Wei T; Hedley, David W; Chow, Sue; Brandwein, Joseph; Schuh, Andre C; Schimmer, Aaron D; Gupta, Vikas; Sanfelice, Deborah; Johnson, Tara; Le, Lisa W; Arnott, Jamie; Bray, Mark R; Sidor, Carolyn; Minden, Mark D

    2016-10-01

    ENMD-2076 is a novel, orally-active molecule that inhibits Aurora A kinase, as well as c-Kit, FLT3 and VEGFR2. A phase I study was conducted to determine the maximum tolerated dose (MTD), recommended phase 2 dose (RP2D) and toxicities of ENMD-2076 in patients with acute myeloid leukemia (AML) and chronic myelomonocytic leukemia (CMML). Patients received escalating doses of ENMD-2076 administered orally daily [225 mg (n = 7), 375 mg (n = 6), 325 mg (n = 9), or 275 mg (n = 5)]. Twenty-seven patients were treated (26 AML; 1 CMML-2). The most common non-hematological toxicities of any grade, regardless of association with drug, were fatigue, diarrhea, dysphonia, dyspnea, hypertension, constipation, and abdominal pain. Dose-limiting toxicities (DLTs) consisted of grade 3 fatigue, grade 3 typhilitis, grade 3 syncope and grade 3 QTc prolongation). Of the 16 evaluable patients, one patient achieved a complete remission with incomplete count recovery (CRi), three experienced a morphologic leukemia-free state (MLFS) with a major hematologic improvement in platelets (HI-P), and 5 other patients had a reduction in marrow blast percentage (i.e. 11-65 %). The RP2D in this patient population is 225 mg orally once daily. PMID:27406088

  7. HIRISE observations of daytime aurora over boston from ground in response to the magnetic disturbance of october 30, 2003 as corroborated by the TIMED measurements from space

    Science.gov (United States)

    Pallamraju, D.; Chakrabarti, S.

    HIRISE (High Resolution Imaging Spectrograph using Echelle grating) is a high-resolution spectrograph built at Boston University, which is capable of making unambiguous ground-based daytime airglow/aurora measurements. HIRISE has been making daytime red line (OI 630.0nm) emission measurements from Boston (42.2° N, 71° W) on all clear sky days since April 2003. On October 30, 2003, in response to a severe geomagnetic disturbance, HIRISE measured intense daytime red line emissions of 15 KR (scattered background continuum around 2 MRÅ-1)^at 1500 LT (2000 UT; SZA around 75°), which are a factor of 6 -- 8 greater when compared to the typical quiet time dayglow emission rates at that time. Interplanetary magnetic field (IMF) Bz stayed negative throughout that day but showed a monotonic increase from --20 nT at 0 UT to --15 nT by 24 UT. IMF By was mostly positive (around 5 nT) throughout the day, which is known to move the precipitation/interaction region towards postnoon time, raising interest on whether the magnetospheric cusps moved as far down to mid-latitudes on this day. GUVI (Global UltraViolet Imager) onboard TIMED (Thermosphere, Ionosphere, and Mesosphere Energetics and Dynamics) satellite showed nearly an order of magnitude enhancements in irradiances of 1356 and LBH emissions during this time as compared to the quiet time values. Comparison against TIMED Doppler Interferometer (TIDI) brightness data will also be made. These different simultaneous measurements will be presented.

  8. Icaritin suppresses development of neuroendocrine differentiation of prostate cancer through inhibition of IL-6/STAT3 and Aurora kinase A pathways in TRAMP mice.

    Science.gov (United States)

    Sun, Feng; Zhang, Zhi Wei; Tan, Ee Min; Lim, Z L Ryan; Li, Yu; Wang, Xiao Chong; Chua, Seok Eng; Li, Jun; Cheung, Edwin; Yong, Eu-Leong

    2016-07-01

    Neuroendocrine prostate cancer (NEPC) has a poor prognosis, with a median survival of less than 1 year after diagnosis. Following androgen deprivation therapy, prostate adenocarcinoma cells have been observed to develop an androgen receptor-negative, terminally differentiated and indolent neuroendocrine-like phenotype. However, several molecular events, including interleukin 6 (IL-6) stimulation, in the prostate microenvironment result in the appearance of aggressive, highly proliferative castrate-resistant NEPC. In this study, we examined the mechanistic effects of a natural prenylflavonoid, icaritin (ICT), on neuroendocrine differentiation in IL-6-induced LNCaP cells and NEPC development in the male transgenic adenocarcinoma of the mouse prostate (TRAMP) model. TRAMP mice received daily intraperitoneal injection of ICT or vehicle. ICT induced apoptosis in prostate tumor, suppressed NEPC development and, accordingly, improved overall survival in TRAMP mice. Expression of neuroendocrine markers (synaptophysin) and androgen receptor in TRAMP mice and neuroendocrine-like LNCaP cells were inhibited by ICT. Suppression of neuroendocrine and NEPC development by ICT was associated with dose-dependent inhibitory effects on abnormally elevated IL-6/STAT3 and Aurora kinase A in vitro and in vivo Since ICT demonstrated favorable pharmacokinetic and safety profiles with marked enrichment in prostate tissues, our study provides evidence for the development of prenylflavonoid as a multimodal therapeutic agent against NEPC. PMID:27207661

  9. Epithelial Cell Transforming 2 and Aurora Kinase B Modulate Formation of Stress Granule-Containing Transcripts from Diverse Cellular Pathways in Astrocytoma Cells.

    Science.gov (United States)

    Weeks, Adrienne; Agnihotri, Sameer; Lymer, Jennifer; Chalil, Alan; Diaz, Roberto; Isik, Semra; Smith, Christian; Rutka, James T

    2016-06-01

    Stress granules are small RNA-protein granules that modify the translational landscape during cellular stress to promote survival. The RhoGTPase RhoA is implicated in the formation of RNA stress granules. Our data demonstrate that the cytokinetic proteins epithelial cell transforming 2 and Aurora kinase B (AurkB) are localized to stress granules in human astrocytoma cells. AurkB and its downstream target histone-3 are phosphorylated during arsenite-induced stress. Chemical (AZD1152-HQPA) and siRNA inhibition of AurkB results in fewer and smaller stress granules when analyzed using high-throughput fluorescent-based cellomics assays. RNA immunoprecipitation with the known stress granule aggregates TIAR and G3BP1 was performed on astrocytoma cells, and subsequent analysis revealed that astrocytoma stress granules harbor unique mRNAs for various cellular pathways, including cellular migration, metabolism, translation, and transcriptional regulation. Human astrocytoma cell stress granules contain mRNAs that are known to be involved in glioma signaling and the mammalian target of rapamycin pathway. These data provide evidence that RNA stress granules are a novel form of epigenetic regulation in astrocytoma cells, which may be targetable by chemical inhibitors and enhance astrocytoma susceptibility to conventional therapy, such as radiation and chemotherapy. PMID:27106762

  10. Survey of wildlife, including aquatic mammals, associated with riparian habitat on the Syncrude Canada Ltd. Aurora Mine environmental impact assessment local study area

    International Nuclear Information System (INIS)

    A general overview of the wildlife associated with riparian habitats at Syncrude's proposed Aurora Mine, located 70 km northeast of Fort McMurray, Alberta on the east side of the Athabasca River, was presented. The area is underlain by bitumen and is being considered for bitumen extraction and production of synthetic crude oil. Two surveys were conducted with the help of experienced trappers from the community at Fort McKay. One was an aerial survey on November 3, 1995, the other a ground survey on November 29-30, 1995. The two surveys yielded 248 observed tracks on four 500 metre transects. The study area was comprised of boreal forest with natural drainage via Stanley Creek into the Muskeg River and via Fort Creek into the Athabasca River. Beavers, fox, weasel, mink, rabbit, wolf, moose, deer, ptarmigan, sharp-tailed grouse and ruffed grouse, lynx, coyote, river otter and mice were associated with riparian habitat on the study area. There was no sign of muskrat in the study area. It was concluded that in order to develop an understanding of reclamation alternatives for mined areas in the region, future detailed examination of the site should be approached through the integration of traditional ecological knowledge and conventional scientific methodology. 26 refs., 12 tabs., 2 figs

  11. Berkeley Low Background Facility

    International Nuclear Information System (INIS)

    The Berkeley Low Background Facility (BLBF) at Lawrence Berkeley National Laboratory (LBNL) in Berkeley, California provides low background gamma spectroscopy services to a wide array of experiments and projects. The analysis of samples takes place within two unique facilities; locally within a carefully-constructed, low background laboratory on the surface at LBNL and at the Sanford Underground Research Facility (SURF) in Lead, SD. These facilities provide a variety of gamma spectroscopy services to low background experiments primarily in the form of passive material screening for primordial radioisotopes (U, Th, K) or common cosmogenic/anthropogenic products; active screening via neutron activation analysis for U,Th, and K as well as a variety of stable isotopes; and neutron flux/beam characterization measurements through the use of monitors. A general overview of the facilities, services, and sensitivities will be presented. Recent activities and upgrades will also be described including an overview of the recently installed counting system at SURF (recently relocated from Oroville, CA in 2014), the installation of a second underground counting station at SURF in 2015, and future plans. The BLBF is open to any users for counting services or collaboration on a wide variety of experiments and projects

  12. Comprehensive facilities plan

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-09-01

    The Ernest Orlando Lawrence Berkeley National Laboratory`s Comprehensive Facilities Plan (CFP) document provides analysis and policy guidance for the effective use and orderly future development of land and capital assets at the Berkeley Lab site. The CFP directly supports Berkeley Lab`s role as a multiprogram national laboratory operated by the University of California (UC) for the Department of Energy (DOE). The CFP is revised annually on Berkeley Lab`s Facilities Planning Website. Major revisions are consistent with DOE policy and review guidance. Facilities planing is motivated by the need to develop facilities for DOE programmatic needs; to maintain, replace and rehabilitate existing obsolete facilities; to identify sites for anticipated programmatic growth; and to establish a planning framework in recognition of site amenities and the surrounding community. The CFP presents a concise expression of the policy for the future physical development of the Laboratory, based upon anticipated operational needs of research programs and the environmental setting. It is a product of the ongoing planning processes and is a dynamic information source.

  13. Power Systems Development Facility

    International Nuclear Information System (INIS)

    The objective of the PSDF would be to provide a modular facility which would support the development of advanced, pilot-scale, coal-based power systems and hot gas clean-up components. These pilot-scale components would be designed to be large enough so that the results can be related and projected to commercial systems. The facility would use a modular approach to enhance the flexibility and capability for testing; consequently, overall capital and operating costs when compared with stand-alone facilities would be reduced by sharing resources common to different modules. The facility would identify and resolve technical barrier, as well as-provide a structure for long-term testing and performance assessment. It is also intended that the facility would evaluate the operational and performance characteristics of the advanced power systems with both bituminous and subbituminous coals. Five technology-based experimental modules are proposed for the PSDF: (1) an advanced gasifier module, (2) a fuel cell test module, (3) a PFBC module, (4) a combustion gas turbine module, and (5) a module comprised of five hot gas cleanup particulate control devices. The final module, the PCD, would capture coal-derived ash and particles from both the PFBC and advanced gasifier gas streams to provide for overall particulate emission control, as well as to protect the combustion turbine and the fuel cell

  14. Berkeley Low Background Facility

    Energy Technology Data Exchange (ETDEWEB)

    Thomas, K. J.; Norman, E. B. [Department of Nuclear Engineering, University of California-Berkeley, CA 94720 (United States); Nuclear Science Division, Lawrence Berkeley National Laboratory, CA 94720 (United States); Smith, A. R.; Poon, A. W. P.; Chan, Y. D. [Nuclear Science Division, Lawrence Berkeley National Laboratory, CA 94720 (United States); Lesko, K. T. [Physics Division, Lawrence Berkeley National Laboratory, CA 94720 (United States)

    2015-08-17

    The Berkeley Low Background Facility (BLBF) at Lawrence Berkeley National Laboratory (LBNL) in Berkeley, California provides low background gamma spectroscopy services to a wide array of experiments and projects. The analysis of samples takes place within two unique facilities; locally within a carefully-constructed, low background laboratory on the surface at LBNL and at the Sanford Underground Research Facility (SURF) in Lead, SD. These facilities provide a variety of gamma spectroscopy services to low background experiments primarily in the form of passive material screening for primordial radioisotopes (U, Th, K) or common cosmogenic/anthropogenic products; active screening via neutron activation analysis for U,Th, and K as well as a variety of stable isotopes; and neutron flux/beam characterization measurements through the use of monitors. A general overview of the facilities, services, and sensitivities will be presented. Recent activities and upgrades will also be described including an overview of the recently installed counting system at SURF (recently relocated from Oroville, CA in 2014), the installation of a second underground counting station at SURF in 2015, and future plans. The BLBF is open to any users for counting services or collaboration on a wide variety of experiments and projects.

  15. FACILITIES MANAGEMENT AT CERN

    CERN Multimedia

    2002-01-01

    Recently we have been confronted with difficulties concerning services which are part of a new contract for facilities management. Please see below for some information about this contract. Following competitive tendering and the Finance Committee decision, the contract was awarded to the Swiss firm 'Facilities Management Network (FMN)'. The owners of FMN are two companies 'M+W Zander' and 'Avireal', both very experienced in this field of facilities management. The contract entered into force on 1st July 2002. CERN has grouped together around 20 different activities into this one contract, which was previously covered by separate contracts. The new contract includes the management and execution of many activities, in particular: Guards and access control; cleaning; operation and maintenance of heating plants, cooling and ventilation equipment for buildings not related to the tunnel or the LHC; plumbing; sanitation; lifts; green areas and roads; waste disposal; and includes a centralised helpdesk for these act...

  16. Experimental facilities for KAON

    International Nuclear Information System (INIS)

    In order to ensure that the type of experimental facilities provided at the TRIUMF KAON Factory meet the needs of physicists, TRIUMF is seeking advice from the physics community by sponsoring a number of workshops. A list of desired facilities has been made. From this list it is learned that channels providing charged particles, K±'s (π±'s and polarized p's) at all the possible energies would be desirable. As well there will be a need for a neutral kaon beam, a neutrino beam, muon spin resonance beams and an area for extracted polarized proton studies. Some of these latter studies could be done using internal targets, so an area for such must also be included. Tasks still requiring input include definition the requirements for the polarized proton beam area, internal targets, neutrino facility, kaon spectrometers and/or detectors, production targets, and proton beams downstream of production targets

  17. Mirror Fusion Test Facility

    International Nuclear Information System (INIS)

    On October 1, 1977 work began at LLL on the Mirror Fusion Test Facility (MFTF), an advanced experimental fusion device. Scheduled for operation in late 1981, MFTF is designed as an intermediate step between present mirror machines, such as 2XIIB, and an experimental fusion reactor. This design incorporates improved technology and a better theoretical understanding of how neutral beam injection, plasma guns, and gas injection into the plasma region compensate for cooling and particle losses. With the new facility, we expect to achieve a confinement factor (n tau) of 1012 particles . sm/cm3--a tenfold increase over 2XIIB n tau values--and to increase plasma temperature to over 500 million K. The following article describes this new facility and reports on progress in some of the R and D projects that are providing the technological base for its construction

  18. Electromagnetic propulsion test facility

    Science.gov (United States)

    Gooder, S. T.

    1984-01-01

    A test facility for the exploration of electromagnetic propulsion concept is described. The facility is designed to accommodate electromagnetic rail accelerators of various lengths (1 to 10 meters) and to provide accelerating energies of up to 240 kiloJoules. This accelerating energy is supplied as a current pulse of hundreds of kiloAmps lasting as long as 1 millisecond. The design, installation, and operating characteristics of the pulsed energy system are discussed. The test chamber and its operation at pressures down to 1300 Pascals (10 mm of mercury) are described. Some aspects of safety (interlocking, personnel protection, and operating procedures) are included.

  19. Line facilities outline

    International Nuclear Information System (INIS)

    This book deals with line facilities. The contents of this book are outline line of wire telecommunication ; development of line, classification of section of line and theory of transmission of line, cable line ; structure of line, line of cable in town, line out of town, domestic cable and other lines, Optical communication ; line of optical cable, transmission method, measurement of optical communication and cable of the sea bottom, Equipment of telecommunication line ; telecommunication line facilities and telecommunication of public works, construction of cable line and maintenance and Regulation of line equipment ; regulation on technique, construction and maintenance.

  20. Bevalac Radiotherapy Facility

    International Nuclear Information System (INIS)

    Patient Treatment Room at the Bevalac is now in full operation. In the design of this facility, emphasis has been placed on creating an atmosphere appropriate to a clinical facility; the usual features of an irradiation cave have been hidden behind carpets, curtains and paint. Patient positioning is done with a Philips Ram-style couch, with additional fixtures to accommodate a patient in the seated or standing, as well as the supine, position. Dosimetry apparatus, collimators, ion chambers and the beam flattening system used to produce the highly uniform 20 cm diameter therapy field are described

  1. Multipurpose dry storage facilities

    International Nuclear Information System (INIS)

    SGN has gained considerable experience in the design and construction of interim storage facilities for spent fuel and various nuclear waste, and can therefore propose single product and multiproduct facilities capable of accommodating all types of waste in a single structure. The pooling of certain functions (transport cask reception, radiation protection), the choice of optimized technologies to meet the specific needs of the clients (automatic transfer by shielded cask or nuclearized crane) and the use of the same type of well to cool the heat releasing packages (glass canisters, fuel elements) make it possible to propose industrially proven and cost effective solutions. The studies conducted by SGN on behalf of the Dutch company COVRA (Centrale Organisatie Voor Radioactif Afval), offer an example of the application of this new concept. This paper first presents the SGN experience through a short description of reference storage facilities for various types of products (MLW, HLW and Spent Fuel). It goes on with a typical application to show how these proven technologies are combined to obtain single product or multiproduct facilities tailored to the client's specific requirements. (author)

  2. Basic nuclear facilities

    International Nuclear Information System (INIS)

    This document reprints the text of the French by-law from February 21, 2002 relative to the information of populations living in the vicinity of a facility for which a particular emergency plan exists. The by-law precises the content of the information documents intended for the populations living in the area of application of the plan. (J.S.)

  3. Facility Modernization Report

    Energy Technology Data Exchange (ETDEWEB)

    Robinson, D; Ackley, R

    2007-05-10

    Modern and technologically up-to-date facilities and systems infrastructure are necessary to accommodate today's research environment. In response, Lawrence Livermore National Laboratory (LLNL) has a continuing commitment to develop and apply effective management models and processes to maintain, modernize, and upgrade its facilities to meet the science and technology mission. The Facility Modernization Pilot Study identifies major subsystems of facilities that are either technically or functionally obsolete, lack adequate capacity and/or capability, or need to be modernized or upgraded to sustain current operations and program mission. This study highlights areas that need improvement, system interdependencies, and how these systems/subsystems operate and function as a total productive unit. Although buildings are 'grandfathered' in and are not required to meet current codes unless there are major upgrades, this study also evaluates compliance with 'current' building, electrical, and other codes. This study also provides an evaluation of the condition and overall general appearance of the structure.

  4. Decommissioning of Nuclear Facilities

    International Nuclear Information System (INIS)

    Atomic Energy Regulatory Board (AERB) is of the view that every organisation should focus attention on the decommissioning of nuclear facilities after completion of their useful life. AERB is aware that, internationally there is a growing interest in plant life extension due to economic considerations. Regulatory bodies stipulate upgradation of safety features based on international experience and current safety standards. However, decommissioning becomes a necessity at some time after the extended life of the plant. Nuclear industry has demonstrated that, with modern technological developments, decommissioning of nuclear facilities can be carried out without undue risk to the occupational workers, members of the public and protection of the environment. In view of limited experience in the field of decommissioning, this document is being issued as a safety manual instead of a safety guide. This manual elaborates the various technical and safety considerations in the decommissioning of nuclear facilities including ultimate disposal of radioactive materials/ wastes generated during decommissioning. Details that are required to be furnished to the regulatory body while applying for authorisation for decommissioning and till its completion are enumerated. This manual is issued to assist Department of Atomic Energy (DAE) units in formulating a decommissioning programme. Since the subject of decommissioning of nuclear facilities is a continuously evolving process, AERB is of the view, that provisions of this manual will apply for a period of five years from the date of issue and will be subsequently revised, if necessary

  5. Dismantling of nuclear facilities

    International Nuclear Information System (INIS)

    Nuclear facilities have a long estimable lifetime but necessarily limited in time. At the end of their operation period, basic nuclear installations are the object of cleansing operations and transformations that will lead to their definitive decommissioning and then to their dismantling. Because each facility is somewhere unique, cleansing and dismantling require specific techniques. The dismantlement consists in the disassembly and disposing off of big equipments, in the elimination of radioactivity in all rooms of the facility, in the demolition of buildings and eventually in the reconversion of all or part of the facility. This article describes these different steps: 1 - dismantling strategy: main de-construction guidelines, expected final state; 2 - industries and sites: cleansing and dismantling at the CEA, EDF's sites under de-construction; 3 - de-construction: main steps, definitive shutdown, preparation of dismantling, electromechanical dismantling, cleansing/decommissioning, demolition, dismantling taken into account at the design stage, management of polluted soils; 4 - waste management: dismantlement wastes, national policy of radioactive waste management, management of dismantlement wastes; 5 - mastery of risks: risk analysis, conformability of risk management with reference documents, main risks encountered at de-construction works; 6 - regulatory procedures; 7 - international overview; 8 - conclusion. (J.S.)

  6. Facilities of Environmental Distinction

    Science.gov (United States)

    Pascopella, Angela

    2011-01-01

    Three of nine school buildings that have won the latest Educational Facility Design Awards from the American Institute of Architects (AIA) Committee on Architecture for Education stand out from the crowd of other school buildings because they are sustainable and are connected to the nature that surrounds them. They are: (1) Thurston Elementary…

  7. Track and Field Facilities.

    Science.gov (United States)

    Wood, Tony

    2001-01-01

    Discusses planning and design tips that help ensure track and field facilities are successful and well-suited to both school and community use. Examines approaches to determining the best track surface and ways to maximize track and field flexibility with limited space. (GR)

  8. PFP Wastewater Sampling Facility

    International Nuclear Information System (INIS)

    This test report documents the results obtained while conducting operational testing of the sampling equipment in the 225-WC building, the PFP Wastewater Sampling Facility. The Wastewater Sampling Facility houses equipment to sample and monitor the PFP's liquid effluents before discharging the stream to the 200 Area Treated Effluent Disposal Facility (TEDF). The majority of the streams are not radioactive and discharges from the PFP Heating, Ventilation, and Air Conditioning (HVAC). The streams that might be contaminated are processed through the Low Level Waste Treatment Facility (LLWTF) before discharging to TEDF. The sampling equipment consists of two flow-proportional composite samplers, an ultrasonic flowmeter, pH and conductivity monitors, chart recorder, and associated relays and current isolators to interconnect the equipment to allow proper operation. Data signals from the monitors are received in the 234-5Z Shift Office which contains a chart recorder and alarm annunciator panel. The data signals are also duplicated and sent to the TEDF control room through the Local Control Unit (LCU). Performing the OTP has verified the operability of the PFP wastewater sampling system. This Operability Test Report documents the acceptance of the sampling system for use

  9. Facility effluent monitoring

    Energy Technology Data Exchange (ETDEWEB)

    Gleckler, B.P.

    1995-06-01

    This section of the 1994 Hanford Site Environmental Report summarizes the facility effluent monitoring programs and provides an evaluation of effluent monitoring data. These evaluations are useful in assessing the effectiveness of effluent treatment and control systems, as well as management practices.

  10. Food Service Facilities.

    Science.gov (United States)

    Rifenbark, Ray

    This annotated bibliography included summaries of 14 articles and one report dealing with the topic of school and college food service programs. A brief introduction discusses the current trend toward more diversified use of food service facilities and describes recent innovations in the preparation and distribution of students' meals. Many of the…

  11. Toroid magnet test facility

    CERN Multimedia

    2002-01-01

    Because of its exceptional size, it was not feasible to assemble and test the Barrel Toroid - made of eight coils - as an integrated toroid on the surface, prior to its final installation underground in LHC interaction point 1. It was therefore decided to test these eight coils individually in a dedicated test facility.

  12. Invasive Fungal Infections in Patients with Hematologic Malignancies (Aurora Project: Lights and Shadows During 18-Months Surveillance

    Directory of Open Access Journals (Sweden)

    Giorgina Specchia

    2012-01-01

    Full Text Available The aim of this multicenter prospective study was to evaluate the incidence of invasive fungal infections (IFIs in adult and pediatric patients with hematologic malignancies, involving nine nosocomial facilities in Southern Italy over a period of 18 months. Furthermore, results of an environmental microbial surveillance routinely carried out in some of the enrolled hospitals are reported. A total of 589 onco-hematological patients were enrolled and 27 IFIs were documented. The main infections were caused by yeasts, more than filamentous fungi (overall incidence of 2.7% and 1.9%, respectively. The yeasts were mainly represented by Candida spp. (87.5%, all isolated by blood cultures; C. parapsilosis was the most common species. Among mould infections, the most frequent site was the lung, with regard to aspergillosis (81.8%. In six of the 10 patients with suspected aspergillosis, the diagnosis was made by the detection of galactomannan and (1,3-β-d-glucan antigens. The microbiological surveillance carried out on 156 air, 312 water and 312 surface samples revealed low environmental contamination: Alternaria alternata was the only fungus isolated from two surface samples. Our data, especially the low occurrence of filamentous fungi, suggest a particular local epidemiology. Further studies are needed to confirm this microbiological trend in onco-hematological patients in Southern Italy, the results of which might be helpful to improve the management of these patients.

  13. Simultaneous multi-scale and multi-instrument observations of Saturn's aurorae during the 2013 observing campaign

    Science.gov (United States)

    Melin, Henrik; Badman, S. V.; Stallard, T. S.; Cowley, S. W. H.; Dyudina, U.; Nichols, J. D.; Provan, G.; O'Donoghue, J.; Pryor, W. R.; Baines, K. H.; Miller, S.; Gustin, J.; Radioti, A.; Tao, C.; Meredith, C. J.; Blake, J. S. D.; Johnson, R. E.

    2016-01-01

    On 21 April 2013, during a co-ordinated Saturn auroral observing campaign, the northern and southern poles of the planet were observed from the Earth using the NASA Infrared Telescope Facility (IRTF), Keck, and Hubble Space Telescope (HST) simultaneously with the Cassini infrared, visible, and ultraviolet remote sensing instruments. We present simultaneous multi-scale and multi-wavelength analysis of the morphology of auroral emissions at Saturn. The visible main auroral emission vary between ∼ 2 and 10 kR on timescales of minutes and across spatial scales of down to ∼ 14 km on the planet. The H2 Far Ultraviolet (FUV) brightness varies by a factor of ∼ 10, from ∼ 4-40 kR, over timescales of 1 min and spatial scales of 720 km. H3+ infrared emissions vary less than the H2 emissions, from ∼ 5-10 μ W m-2 sr-1, over similar spatial scales (∼ 300 km) and timescales of a few seconds to a few hours. The fine-scale temporal and spatial features seen in the main oval show that complex structures are present even during quiet solar wind conditions. Diffuse ultraviolet emissions southward of the southern midnight main oval that are not seen in the infrared, implying a steep temperature gradient of ∼ 50 K over 2-4 ° latitude equatorward of the main oval. Dynamics on scales of ∼ 100 km at the poles are revealed by lower spatial resolution observations, the morphologies of which are partly consistent with overlapping local-time fixed and co-rotating current systems. We also present the first direct comparison of simultaneous infrared, visible, and ultraviolet auroral emissions at Saturn. Finally, the main auroral emissions are found to be approximately co-located in the midnight sector, forming an arc with a width of ∼ 0.5-1 ° , at 72-74° southern latitude, moving slightly equatorward with increasing local-time.

  14. EPA Facility Registry Service (FRS): Facility Interests Dataset - Intranet

    Data.gov (United States)

    U.S. Environmental Protection Agency — This web feature service consists of location and facility identification information from EPA's Facility Registry Service (FRS) for all sites that are available in...

  15. EPA Facility Registry Service (FRS): Facility Interests Dataset - Intranet Download

    Data.gov (United States)

    U.S. Environmental Protection Agency — This downloadable data package consists of location and facility identification information from EPA's Facility Registry Service (FRS) for all sites that are...

  16. Assisted Living Facilities, care facilities, Published in 2006, Washoe County.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Assisted Living Facilities dataset, was produced all or in part from Published Reports/Deeds information as of 2006. It is described as 'care facilities'. Data...

  17. EPA Facility Registry Service (FRS): Facility Interests Dataset Download

    Data.gov (United States)

    U.S. Environmental Protection Agency — This downloadable data package consists of location and facility identification information from EPA's Facility Registry Service (FRS) for all sites that are...

  18. EPA Facility Registry Service (FRS): Facility Interests Dataset

    Data.gov (United States)

    U.S. Environmental Protection Agency — This web feature service consists of location and facility identification information from EPA's Facility Registry Service (FRS) for all sites that are available in...

  19. EPA Facility Registry Service (FRS): AIRS_AFS Sub Facilities

    Data.gov (United States)

    U.S. Environmental Protection Agency — The Air Facility System (AFS) contains compliance and permit data for stationary sources regulated by EPA, state and local air pollution agencies. The sub facility...

  20. The maternal-effect gene cellular island encodes aurora B kinase and is essential for furrow formation in the early zebrafish embryo.

    Directory of Open Access Journals (Sweden)

    Taijiro Yabe

    2009-06-01

    Full Text Available Females homozygous for a mutation in cellular island (cei produce embryos with defects in cytokinesis during early development. Analysis of the cytoskeletal events associated with furrow formation reveal that these defects include a general delay in furrow initiation as well as a complete failure to form furrow-associated structures in distal regions of the blastodisc. A linkage mapping-based candidate gene approach, including transgenic rescue, shows that cei encodes the zebrafish Aurora B kinase homologue. Genetic complementation analysis between the cei mutation and aurB zygotic lethal mutations corroborate gene assignment and reveal a complex nature of the maternal-effect cei allele, which appears to preferentially affect a function important for cytokinesis in the early blastomeres. Surprisingly, in cei mutant embryos a short yet otherwise normal furrow forms in the center of the blastodisc. Furrow formation is absent throughout the width of the blastodisc in cei mutant embryos additionally mutant for futile cycle, which lack a spindle apparatus, showing that the residual furrow signal present in cei mutants is derived from the mitotic spindle. Our analysis suggests that partially redundant signals derived from the spindle and astral apparatus mediate furrow formation in medial and distal regions of the early embryonic blastomeres, respectively, possibly as a spatial specialization to achieve furrow formation in these large cells. In addition, our data also suggest a role for Cei/AurB function in the reorganization of the furrow-associated microtubules in both early cleavage- and somite-stage embryos. In accordance with the requirement for cei/aurB in furrow induction in the early cleavage embryo, germ plasm recruitment to the forming furrow is also affected in embryos lacking normal cei/aurB function.