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Sample records for aurin

  1. Ascertainment of aurin ear drops antimicrobial and healing effect in dog otitis

    Directory of Open Access Journals (Sweden)

    Borisov Ivan

    2004-01-01

    Full Text Available Microbiological and clinical examinations have been made, related to the effect of Aurin ear drops - the solution "Primavet - Sofia" on dogs with acute and chronic conditions of external and media otitis. The pharmaceutical compatibility of the active substances and solution stability were examined. The inhibitory effects in vitro of Acidum boricum, Acidwn salicylicum Ethanolum and Aurin - solution on laboratory referents and clinically isolated strains of microorganisms were studied. The dosage and manner of application were specified and was considered the effect on different clinical forms of otitis were specified. In the course of the one-year examination period, it was ascertained that Aurin-solution possesses the necessary stability. The active Aurin-solution substances (Acidum boricum Acidum salicylicum, Novocainum secure optimal composition of supporting substances, and high inhibitory activity in vitro on microbial strains in the examined agents of dog otitis. A dosage of 10 to 20 drops and touching the earconch with 5-10 drops twice a day, in the course of 5-7 days, has local antiseptic, anti-inflammatory, antimycotic and pain soothing effects. The healing effect of Aurin is due to selective antibacterial and antimycotic effects of the active substances used. The effectiveness against otitis is due to synergism of the effects of active and supporting substances. The obtained clinical results present grounds for recommending Aurin - ear drops as an effective method of healing dog otitis.

  2. Bone marrow aluminium storage in renal failure.

    OpenAIRE

    Kaye, M.

    1983-01-01

    Using the staining method for aluminium with the ammonium salt of aurine tricarboxylic acid, aluminon, 18 patients with end stage renal disease gave positive reactions in iliac crest bone biopsies and 11 of these had positive staining in the bone marrow. In one the marrow was positive and the bone negative. The marrow reaction is putatively regarded as caused by aluminium storage in unidentified cells, possibly of the macrophage system which are strongly fluorescent when examined after prior ...

  3. 肉体労作後の尿蛋白に関する研究 第2報 濾紙CBB-G250色素法を用いた尿微量蛋白の新定量法

    OpenAIRE

    宮井, 泰三

    1987-01-01

    A simple and sensitive method for rapid semiquantitative and quantitative determinations of urinary protein was devised, in which protein absorbed and fixed on filter paper containing sulfosalicylic acid was reacted with Coomassie Brilliant Blue G-250 (CBB). For the semiquantitative method, filter paper (NO. 50, Toyo) was immersed in a 20% sulfosalicylic acid solution and dried. Dried filter paper was immersed in aurine, dried again immersed TONEIN (Othuka Assay Laboratories) and compared wit...

  4. Solubility enhancement of simvastatin by arginine: thermodynamics, solute–solvent interactions, and spectral analysis

    OpenAIRE

    Meor Mohd Affandi MMR; Tripathy M; Shah SAA; Majeed ABA

    2016-01-01

    MMR Meor Mohd Affandi,1,2 Minaketan Tripathy,1,3 Syed Adnan Ali Shah,3,4 ABA Majeed1,3 1Laboratory of Fundamental Pharmaceutics, Faculty of Pharmacy, Universiti Teknologi MARA (UiTM), Bandar Puncak Alam, Selangor, Malaysia; 2DDH Core, Universiti Teknologi MARA (UiTM), Shah Alam, Selangor Darul Ehsan, Malaysia; 3Pharmaceutical and Life Sciences Core, Universiti Teknologi MARA (UiTM), Shah Alam, Selangor Darul Ehsan, Malaysia; 4Atta-ur-Rahman Institute for Natural Products Discovery (AuRIns), ...

  5. Inhibition of aberrant complement activation by a dimer of acetylsalicylic acid.

    Science.gov (United States)

    Lee, Moonhee; Wathier, Matthew; Love, Jennifer A; McGeer, Edith; McGeer, Patrick L

    2015-10-01

    We here report synthesis for the first time of the acetyl salicylic acid dimer 5,5'-methylenebis(2-acetoxybenzoic acid) (DAS). DAS inhibits aberrant complement activation by selectively blocking factor D of the alternative complement pathway and C9 of the membrane attack complex. We have previously identified aurin tricarboxylic and its oligomers as promising agents in this regard. DAS is much more potent, inhibiting erythrocyte hemolysis by complement-activated serum with an IC50 in the 100-170 nanomolar range. There are numerous conditions where self-damage from the complement system has been implicated in the pathology, including such chronic degenerative diseases of aging as Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and age-related macular degeneration. Consequently, there is a high priority for the discovery and development of agents that can successfully treat such conditions. DAS holds considerable promise for being such an agent.

  6. Effect of Molecular Coupling on Ultrafast Electron-Transfer and Charge-Recombination Dynamics in a Wide-Gap ZnS Nanoaggregate Sensitized by Triphenyl Methane Dyes.

    Science.gov (United States)

    Debnath, Tushar; Maity, Partha; Dana, Jayanta; Ghosh, Hirendra N

    2016-03-01

    Wide-band-gap ZnS nanocrystals (NCs) were synthesized, and after sensitizing the NCs with series of triphenyl methane (TPM) dyes, ultrafast charge-transfer dynamics was demonstrated. HRTEM images of ZnS NCs show the formation of aggregate crystals with a flower-like structure. Exciton absorption and lumimescence, due to quantum confinement of the ZnS NCs, appear at approximately 310 and 340 nm, respectively. Interestingly, all the TPM dyes (pyrogallol red, bromopyrogallol red, and aurin tricarboxylic acid) form charge-transfer complexes with the ZnS NCs, with the appearance of a red-shifted band. Electron injection from the photoexcited TPM dyes into the conduction band of the ZnS NCs is shown to be a thermodynamically viable process, as confirmed by steady-state and time-resolved emission studies. To unravel charge-transfer (both electron injection and charge recombination) dynamics and the effect of molecular coupling, femtosecond transient absorption studies were carried out in TPM-sensitized ZnS NCs. The electron-injection dynamics is pulse-width-limited in all the ZnS/TPM dye systems, however, the back electron transfer differs, depending on the molecular coupling of the sensitizers (TPM dyes). The detailed mechanisms for the above-mentioned processes are discussed. PMID:26548569

  7. Ultrafast excited state dynamics of S2 and S1 states of triphenylmethane dyes.

    Science.gov (United States)

    Singhal, Pallavi; Ghosh, Hirendra N

    2014-08-21

    Excited state dynamics of S2 and S1 states for a series of TPM dyes, pyrogallol red (PGR), bromopyrogallol red (Br-PGR) and aurin tricarboxylic acid (ATC), have been monitored by using ultrafast transient absorption and fluorescence up-conversion techniques. Optical absorption studies indicate that all the TPM dyes exist as keto-enol tautomers depending upon the pH of the solution. Interestingly, all the TPM dyes give S2 emission (major emitting state) in addition to weak S1 emission. S2 emission lifetimes as fast as ∼150-300 fs and S1 emission lifetimes of 2-5 ns were observed depending upon the molecular structure of the dyes. Femtosecond transient absorption studies suggest the presence of an ultrafast non-radiative decay channel from the S2 state in addition to S2 luminescence. The vibrational relaxation time from hot S1 state is found to be 2-6 ps. The heavy atom effect has been observed in ultrafast relaxation dynamics of Br-PGR.

  8. Specific interaction of aurintricarboxylic acid with the human immunodeficiency virus/CD4 cell receptor

    Energy Technology Data Exchange (ETDEWEB)

    Schols, D.; Baba, M.; Pauwels, R.; Desmyter, J.; De Clercq, E. (Katholieke Universiteit Leuven (Belgium))

    1989-05-01

    The triphenylmethane derivative aurintricarboxylic acid (ATA), but not aurin, selectively prevented the binding of OKT4A/Leu-3a monoclonal antibody (mAb) and, to a lesser extent, OKT4 mAb to the CD4 cell receptor for human immunodeficiency virus type 1 (HIV-1). The effect was seen within 1 min at an ATA concentration of 10 {mu}M in various T4{sup +} cells (MT-4, U-937, peripheral blood lymphocytes, and monocytes). It was dose-dependent and reversible. ATA prevented the attachment of radiolabeled HIV-1 particles to MT-4 cells, which could be expected as the result of its specific binding to the HIV/CD4 receptor. Other HIV inhibitors such as suramin, fuchsin acid, azidothymidine, dextran sulfate, heparin, and pentosan polysulfate did not affect OKT4A/Leu-3a mAb binding to the CD4 receptor, although the sulfated polysaccharides suppressed HIV-1 adsorption to the cells at concentrations required for complete protection against HIV-1 cytopathogenicity. Thus, ATA is a selective marker molecule for the CD4 receptor. ATA also interfered with the staining of membrane-associated HIV-1 glycoprotein gp120 by a mAb against it. These unusual properties of a small molecule of nonimmunological origin may have important implications for the study of CD4/HIV/AIDS pathogenesis and possibly treatment.

  9. Solubility enhancement of simvastatin by arginine: thermodynamics, solute–solvent interactions, and spectral analysis

    Directory of Open Access Journals (Sweden)

    Meor Mohd Affandi MMR

    2016-03-01

    Full Text Available MMR Meor Mohd Affandi,1,2 Minaketan Tripathy,1,3 Syed Adnan Ali Shah,3,4 ABA Majeed1,3 1Laboratory of Fundamental Pharmaceutics, Faculty of Pharmacy, Universiti Teknologi MARA (UiTM, Bandar Puncak Alam, Selangor, Malaysia; 2DDH Core, Universiti Teknologi MARA (UiTM, Shah Alam, Selangor Darul Ehsan, Malaysia; 3Pharmaceutical and Life Sciences Core, Universiti Teknologi MARA (UiTM, Shah Alam, Selangor Darul Ehsan, Malaysia; 4Atta-ur-Rahman Institute for Natural Products Discovery (AuRIns, Faculty of Pharmacy, Universiti Teknologi MARA (UiTM, Bandar Puncak Alam, Selangor, Malaysia Abstract: We examined the solubility of simvastatin in water in 0.01 mol·dm-3, 0.02 mol·dm-3, 0.04 mol·dm-3, 0.09 mol·dm-3, 0.18 mol·dm-3, 0.36 mol·dm-3, and 0.73 mol·dm-3 arginine (ARG solutions. The investigated drug is termed the solute, whereas ARG the cosolute. Phase solubility studies illustrated a higher extent of solubility enhancement for simvastatin. The aforementioned system was subjected to conductometric and volumetric measurements at temperatures (T of 298.15 K, 303.15 K, 308.15 K, and 313.15 K to illustrate the thermodynamics involved and related solute–solvent interactions. The conductance values were used to evaluate the limiting molar conductance and association constants. Thermodynamic parameters (ΔG0, ΔH0, ΔS0, and Es for the association process of the solute in the aqueous solutions of ARG were calculated. Limiting partial molar volumes and expansibilities were evaluated from the density values. These values are discussed in terms of the solute–solvent and solute–cosolute interactions. Further, these systems were analyzed using ultraviolet–visible analysis, Fourier-transform infrared spectroscopy, and 13C, 1H, and two-dimensional nuclear overhauser effect spectroscopy nuclear magnetic resonance to complement thermophysical explanation. Keywords: simvastatin–arginine complex, solubility, volumetric, conductometric

  10. Building Cyberinfrastructures for Earth and Space Sciences so that they will come: lessons learnt from Australia

    Science.gov (United States)

    Wyborn, L. A.; Woodcock, R.

    2013-12-01

    environments and workflows. The eResearch Infrastructure Stack is designed to support 12 individual domain-specific capabilities. Four are relevant to the Earth and Space Sciences: (1) AuScope (a national Earth Science Infrastructure Program), (2) the Integrated Marine Observing System (IMOS), (3) the Terrestrial Ecosystems Research Network (TERN) and (4) the Australian Urban Research Infrastructure Network (AURIN). The two main research integration infrastructures, ANDS and NeCTAR, are seen as pivotal to the success of the Australian eResearch Infrastructure. Without them, there was a risk that that the investments in new computers and data storage would provide physical infrastructure, but few would come to use it as the skills barriers to entry were too high. ANDS focused on transforming Australia's research data environment. Its flagship is Research Data Australia, an Internet-based discovery service designed to provide rich connections between data, projects, researchers and institutions, and promote visibility of Australian research data collections in search engines. NeCTAR focused on building eResearch infrastructure in four areas: virtual laboratories, tools, a federated research cloud and a hosting service. Combined, ANDS and NeCTAR are ensuring that people ARE coming and ARE using the physical infrastructures that were built.