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Sample records for aureus sigma b-dependent

  1. Identification of a sigma B-dependent small noncoding RNA in Listeria monocytogenes

    DEFF Research Database (Denmark)

    Nielsen, Jesper Sejrup; Olsen, Anders Steno; Bonde, Mette

    2008-01-01

    In Listeria monocytogenes, the alternative sigma factor sigma(B) plays important roles in stress tolerance and virulence. Here, we present the identification of SbrA, a novel small noncoding RNA that is produced in a sigma(B)-dependent manner. This finding adds the sigma(B) regulon to the growing...

  2. Identification of sigmaB-dependent genes in Bacillus cereus by proteome and in vitro transcription analysis

    NARCIS (Netherlands)

    Schaik, van W.; Zwietering, M.H.; Vos, de W.M.; Abee, T.

    2004-01-01

    The alternative sigma factor sigma(B) of the food pathogen Bacillus cereus is activated upon stress exposure and plays a role in the adaptive response of vegetative cells. This study describes the identification of sigma(B)-dependent genes in B. cereus. Two-dimensional gel electrophoresis was perfor

  3. Alternative sigma factor sigmaH modulates prophage integration and excision in Staphylococcus aureus.

    Directory of Open Access Journals (Sweden)

    Liang Tao

    2010-05-01

    Full Text Available The prophage is one of the most important components of variable regions in bacterial genomes. Some prophages carry additional genes that may enhance the toxicity and survival ability of their host bacteria. This phenomenon is predominant in Staphylococcus aureus, a very common human pathogen. Bioinformatics analysis of several staphylococcal prophages revealed a highly conserved 40-bp untranslated region upstream of the int gene. A small transcript encoding phage integrase was identified to be initiated from the region, demonstrating that the untranslated region contained a promoter for int. No typical recognition sequence for either sigma(A or sigma(B was identified in the 40-bp region. Experiments both in vitro and in vivo demonstrated that sigma(H recognized the promoter and directed transcription. Genetic deletion of sigH altered the int expression, and subsequently, the excision proportion of prophage DNAs. Phage assays further showed that sigH affected the ability of spontaneous lysis and lysogenization in S. aureus, suggesting that sigH plays a role in stabilizing the lysogenic state. These findings revealed a novel mechanism of prophage integration specifically regulated by a host-source alternative sigma factor. This mechanism suggests a co-evolution strategy of staphylococcal prophages and their host bacteria.

  4. IsdB-dependent hemoglobin binding is required for acquisition of heme by Staphylococcus aureus.

    Science.gov (United States)

    Pishchany, Gleb; Sheldon, Jessica R; Dickson, Claire F; Alam, Md Tauqeer; Read, Timothy D; Gell, David A; Heinrichs, David E; Skaar, Eric P

    2014-06-01

    Staphylococcus aureus is a Gram-positive pathogen responsible for tremendous morbidity and mortality. As with most bacteria, S. aureus requires iron to cause disease, and it can acquire iron from host hemoglobin. The current model for staphylococcal hemoglobin-iron acquisition proposes that S. aureus binds hemoglobin through the surface-exposed hemoglobin receptor IsdB. IsdB removes heme from bound hemoglobin and transfers this cofactor to other proteins of the Isd system, which import and degrade heme to release iron in the cytoplasm. Here we demonstrate that the individual components of the Isd system are required for growth on low nanomolar concentrations of hemoglobin as a sole source of iron. An in-depth study of hemoglobin binding by IsdB revealed key residues that are required for hemoglobin binding. Further, we show that these residues are necessary for heme extraction from hemoglobin and growth on hemoglobin as a sole iron source. These processes are found to contribute to the pathogenicity of S. aureus in a murine model of infection. Together these results build on the model for Isd-mediated hemoglobin binding and heme-iron acquisition during the pathogenesis of S. aureus infection.

  5. The alternative sigma factor B modulates virulence gene expression in a murine Staphylococcus aureus infection model but does not influence kidney gene expression pattern of the host.

    Science.gov (United States)

    Depke, Maren; Burian, Marc; Schäfer, Tina; Bröker, Barbara M; Ohlsen, Knut; Völker, Uwe

    2012-01-01

    Infections caused by Staphylococcus aureus are associated with significant morbidity and mortality and are an increasing threat not only in hospital settings. The expression of the staphylococcal virulence factor repertoire is known to be affected by the alternative sigma factor B (SigB). However, its impact during infection still is a matter of debate. Kidney tissues of controls or mice infected with S. aureus HG001 or its isogenic sigB mutant were analyzed by transcriptome profiling to monitor the host response, and additionally expression of selected S. aureus genes was monitored by RT-qPCR. Direct transcript analysis by RT-qPCR revealed significant SigB activity in all mice infected with the wild-type strain, but not in its isogenic sigB mutant (p<0.0001). Despite a clear-cut difference in the SigB-dependent transcription pattern of virulence genes (clfA, aur, and hla), the host reaction to infection (either wild type or sigB mutant) was almost identical. Despite its significant activity in vivo, loss of SigB did neither have an effect on the outcome of infection nor on murine kidney gene expression pattern. Thus, these data support the role of SigB as virulence modulator rather than being a virulence determinant by itself.

  6. Role of Staphylococcus aureus global regulators sae and sigmaB in virulence gene expression during device-related infection.

    Science.gov (United States)

    Goerke, Christiane; Fluckiger, Ursula; Steinhuber, Andrea; Bisanzio, Vittoria; Ulrich, Martina; Bischoff, Markus; Patti, Joseph M; Wolz, Christiane

    2005-06-01

    The ability of Staphylococcus aureus to adapt to different environments is due to a regulatory network comprising several loci. Here we present a detailed study of the interaction between the two global regulators sae and sigmaB of S. aureus and their influence on virulence gene expression in vitro, as well as during device-related infection. The expression of sae, asp23, hla, clfA, coa, and fnbA was determined in strain Newman and its isogenic saeS/R and sigB mutants by Northern analysis and LightCycler reverse transcription-PCR. There was no indication of direct cross talk between the two regulators. sae had a dominant effect on target gene expression during device-related infection. SigmaB seemed to be less active throughout the infection than under induced conditions in vitro.

  7. On the sigma sigma term

    CERN Document Server

    Bruns, Peter C

    2016-01-01

    We give some estimates for the light-quark mass dependence of the pole position of the sigma ($f_{0}(500)$) resonance in the complex energy plane, with the help of a chiral Lagrangian for the resonance field and some input from hadronic models constrained by Chiral Perturbation Theory and elastic unitarity. We also speculate on the fate of the sigma resonance when the quark masses become unphysically large.

  8. Six sigma.

    Science.gov (United States)

    Carter, Pam

    2010-12-01

    When I was first introduced to the Six Sigma process, I resisted it with every ounce of energy I had. I continuously fabricated reasons so that I was unable to complete the training that my company required. When it came time for my performance review, I could not hide the truth from my manager; I had not completed the required training. It was then that I began my journey into the world of Six Sigma. Once I understood that a black belt and a green belt certification had nothing to do with karate, I felt much better.

  9. Mass splittings in $\\Sigma_b$ and $\\Sigma_b^*$

    OpenAIRE

    Rosner, Jonathan L.

    2006-01-01

    The charged $\\Sigma_b$ and $\\Sigma^*_b$ states have recently been reported by the CDF Collaboration. The relation of their reported charge-averaged masses to expectations based on the quark model is reviewed briefly. A relation is proved among the $\\Delta I = 1$ electromagnetic mass differences $\\Sigma_1 \\equiv M(\\Sigma^+) - M(\\Sigma^-)$, $\\Sigma^*_1 \\equiv M(\\Sigma^{*+})- M(\\Sigma^{*-})$, $\\Sigma_{b1} \\equiv M(\\Sigma_b^+) - M(\\Sigma_b^-)$, and $\\Sigma^*_{b1} \\equiv M(\\Sigma_b^{*+}) - M(\\Sigm...

  10. What is Six Sigma ?

    Directory of Open Access Journals (Sweden)

    Prof. Ph.D. Sorin-George Toma

    2008-12-01

    Full Text Available Over the past decades, several business improvement methods were launched, includingthe one known as Six Sigma. The Six Sigma implies the application of scientific principles to business processesand allows companies to obtain better, faster and cheaper products and services. Motorola was thefirst company that introduced and implemented Six Sigma in its business processes in the 1980s.

  11. What is Six Sigma?

    OpenAIRE

    Gulcin Daglioglu; Inal, Tamer C.; Kiymet Aksoy

    2009-01-01

    Sigma (σ) refers to Standard Deviation which is a measure of variation in statistics. Methodology of Six Sigma is a management philosophy that is based on the theory that parameters can be cotrolled. Six Sigma applications follow the process of identifying and defining defects, analyzing the defects using various measures, suggesting improvements and having metrics or controls in place to achieve the goals of the business. The error rate is defined as the number of error in a million. An...

  12. Six Sigma software development

    CERN Document Server

    Tayntor, Christine B

    2002-01-01

    Since Six Sigma has had marked success in improving quality in other settings, and since the quality of software remains poor, it seems a natural evolution to apply the concepts and tools of Six Sigma to system development and the IT department. Until now however, there were no books available that applied these concepts to the system development process. Six Sigma Software Development fills this void and illustrates how Six Sigma concepts can be applied to all aspects of the evolving system development process. It includes the traditional waterfall model and in the support of legacy systems,

  13. What is Six Sigma?

    Directory of Open Access Journals (Sweden)

    Gulcin Daglioglu

    2009-04-01

    Full Text Available Sigma (σ refers to Standard Deviation which is a measure of variation in statistics. Methodology of Six Sigma is a management philosophy that is based on the theory that parameters can be cotrolled. Six Sigma applications follow the process of identifying and defining defects, analyzing the defects using various measures, suggesting improvements and having metrics or controls in place to achieve the goals of the business. The error rate is defined as the number of error in a million. An increase in Sigma means decrease in the number of error, and lower values of Sigma correspond to higher number of error. The Six Sigma philosophy aims to bring about improvements in processes that have zero error. The Six Sigma approach is to implement methodologies that aim at reaching world standard quality which is 6 Sigma or more. The Six Sigma methodology used in clinical laboratories appears to be a quality management tool involving statistical calculations, process parameter based, and reports about the process performance. [Archives Medical Review Journal 2009; 18(2.000: 132-139

  14. Six Sigma in Education

    Science.gov (United States)

    LeMahieu, Paul G.; Nordstrum, Lee E.; Cudney, Elizabeth A.

    2017-01-01

    Purpose: This paper is one of seven in this volume that aims to elaborate different approaches to quality improvement in education. It delineates a methodology called Six Sigma. Design/methodology/approach: The paper presents the origins, theoretical foundations, core principles and a case study demonstrating an application of Six Sigma in a…

  15. Generalized Poisson sigma models

    CERN Document Server

    Batalin, I; Batalin, Igor; Marnelius, Robert

    2001-01-01

    A general master action in terms of superfields is given which generates generalized Poisson sigma models by means of a natural ghost number prescription. The simplest representation is the sigma model considered by Cattaneo and Felder. For Dirac brackets considerably more general models are generated.

  16. December Sigma-Virginids

    Science.gov (United States)

    Shiba, Yasuo; Ueda, Masayoshi

    2013-02-01

    We studied the December sigma-Virginids from the TV meteor observation network database in Japan (the "SonotaCo Network"). The December sigma-Virginids are a minor annual meteor shower that has a broad peak around December 20 and about 40 days active duration. The visual maximum zenithal hourly rate (ZHR) is estimated at 1.5.

  17. TonB-dependent transporters expressed by Neisseria gonorrhoeae

    Directory of Open Access Journals (Sweden)

    Cynthia N Cornelissen

    2011-05-01

    Full Text Available Neisseria gonorrhoeae causes the common sexually transmitted infection, gonorrhea. This microorganism is an obligate human pathogen, existing nowhere in nature except in association with humans. For growth and proliferation, N. gonorrhoeae requires iron and must acquire this nutrient from within its host. The gonococcus is well-adapted for growth in diverse niches within the human body because it expresses efficient transport systems enabling use of a diverse array of iron sources. Iron transport systems facilitating the use of transferrin, lactoferrin and hemoglobin have two components: one TonB-dependent transporter and one lipoprotein. A single component TonB-dependent transporter also allows N. gonorrhoeae to avail itself of iron bound to heterologous siderophores produced by bacteria within the same ecological niche. Other TonB-dependent transporters are encoded by the gonococcus but have not been ascribed specific functions. The best characterized iron transport system expressed by N. gonorrhoeae enables the use of human transferrin as a sole iron source. This review summarizes the molecular mechanisms involved in gonococcal iron acquisition from human transferrin and also reviews what is currently known about the other TonB-dependent transport systems. No vaccine is available to prevent gonococcal infections and our options for treating this disease are compromised by the emergence of antibiotic resistance. Because iron transport systems are critical for the survival of the gonococcus in vivo, the surface-exposed components of these systems are attractive candidates for vaccine development or therapeutic intervention.

  18. Supersymmetric sigma models

    Energy Technology Data Exchange (ETDEWEB)

    Bagger, J.A.

    1984-09-01

    We begin to construct the most general supersymmetric Lagrangians in one, two and four dimensions. We find that the matter couplings have a natural interpretation in the language of the nonlinear sigma model.

  19. Sigma models on supercosets

    Energy Technology Data Exchange (ETDEWEB)

    Mitev, Vladimir

    2010-08-15

    The purpose of this thesis is to deepen our understanding of the fundamental properties and defining features of non-linear sigma models on superspaces. We begin by presenting the major concepts that we have used in our investigation, namely Lie superalgebras and supergroups, non-linear sigma models and two dimensional conformal field theory. We then exhibit a method, called cohomological reduction, that makes use of the target space supersymmetry of non-linear sigma models to compute certain correlation functions. We then show how the target space supersymmetry of Ricci flat Lie supergroups simplifies the perturbation theory of suitable deformed Wess-Zumino-Witten models, making it possible to compute boundary conformal weights to all orders. This is then applied to the OSP (2S+2 vertical stroke 2S) Gross-Neveu Model, leading to a dual description in terms of the sigma model on the supersphere S{sup 2S+1} {sup vertical} {sup stroke} {sup 2S}. With this results in mind, we then turn to the similar, yet more intricate, theory of the non-linear sigma model on the complex projective superspaces CP{sup N-1} {sup vertical} {sup stroke} {sup N}. The cohomological reduction allows us to compute several important quantities non-perturbatively with the help of the system of symplectic fermions. Combining this with partial perturbative results for the whole theory, together with numerical computations, we propose a conjecture for the exact evolution of boundary conformal weights for symmetry preserving boundary conditions. (orig.)

  20. Inclusive $\\Sigma^{+}$ and $\\Sigma^{0}$ Production in Hadronic Z Decays

    CERN Document Server

    Acciarri, M; Adriani, O; Aguilar-Benítez, M; Alcaraz, J; Alemanni, G; Allaby, James V; Aloisio, A; Alviggi, M G; Ambrosi, G; Anderhub, H; Andreev, V P; Angelescu, T; Anselmo, F; Arefev, A; Azemoon, T; Aziz, T; Bagnaia, P; Bajo, A; Baksay, L; Balandras, A; Banerjee, S; Banerjee, Sw; Barczyk, A; Barillère, R; Barone, L; Bartalini, P; Basile, M; Battiston, R; Bay, A; Becattini, F; Becker, U; Behner, F; Bellucci, L; Berbeco, R; Berdugo, J; Berges, P; Bertucci, B; Betev, B L; Bhattacharya, S; Biasini, M; Biland, A; Blaising, J J; Blyth, S C; Bobbink, Gerjan J; Böhm, A; Boldizsar, L; Borgia, B; Bourilkov, D; Bourquin, Maurice; Braccini, S; Branson, J G; Brigljevic, V; Brochu, F; Buffini, A; Buijs, A; Burger, J D; Burger, W J; Cai, X D; Campanelli, M; Capell, M; Cara Romeo, G; Carlino, G; Cartacci, A M; Casaus, J; Castellini, G; Cavallari, F; Cavallo, N; Cecchi, C; Cerrada-Canales, M; Cesaroni, F; Chamizo-Llatas, M; Chang, Y H; Chaturvedi, U K; Chemarin, M; Chen, A; Chen, G; Chen, G M; Chen, H F; Chen, H S; Chiefari, G; Cifarelli, Luisa; Cindolo, F; Civinini, C; Clare, I; Clare, R; Coignet, G; Colijn, A P; Colino, N; Costantini, S; Cotorobai, F; Cozzoni, B; de la Cruz, B; Csilling, Akos; Cucciarelli, S; Dai, T S; van Dalen, J A; D'Alessandro, R; De Asmundis, R; Déglon, P L; Degré, A; Deiters, K; Della Volpe, D; Denes, P; De Notaristefani, F; De Salvo, A; Diemoz, M; Van Dierendonck, D N; Di Lodovico, F; Dionisi, C; Dittmar, Michael; Dominguez, A; Doria, A; Dova, M T; Duchesneau, D; Dufournaud, D; Duinker, P; Durán, I; El-Mamouni, H; Engler, A; Eppling, F J; Erné, F C; Extermann, Pierre; Fabre, M; Faccini, R; Falagán, M A; Falciano, S; Favara, A; Fay, J; Fedin, O; Felcini, Marta; Ferguson, T; Ferroni, F; Fesefeldt, H S; Fiandrini, E; Field, J H; Filthaut, Frank; Fisher, P H; Fisk, I; Forconi, G; Fredj, L; Freudenreich, Klaus; Furetta, C; Galaktionov, Yu; Ganguli, S N; García-Abia, P; Gataullin, M; Gau, S S; Gentile, S; Gheordanescu, N; Giagu, S; Gong, Z F; Grenier, G; Grimm, O; Grünewald, M W; Guida, M; van Gulik, R; Gupta, V K; Gurtu, A; Gutay, L J; Haas, D; Hasan, A; Hatzifotiadou, D; Hebbeker, T; Hervé, A; Hidas, P; Hirschfelder, J; Hofer, H; Holzner, G; Hoorani, H; Hou, S R; Hu, Y; Iashvili, I; Jin, B N; Jones, L W; de Jong, P; Josa-Mutuberria, I; Khan, R A; Kaur, M; Kienzle-Focacci, M N; Kim, D; Kim, J K; Kirkby, Jasper; Kiss, D; Kittel, E W; Klimentov, A; König, A C; Kopp, A; Koutsenko, V F; Kräber, M H; Krämer, R W; Krenz, W; Krüger, A; Kunin, A; Ladrón de Guevara, P; Laktineh, I; Landi, G; Lassila-Perini, K M; Lebeau, M; Lebedev, A; Lebrun, P; Lecomte, P; Lecoq, P; Le Coultre, P; Lee, H J; Le Goff, J M; Leiste, R; Leonardi, E; Levchenko, P M; Li Chuan; Likhoded, S A; Lin, C H; Lin, W T; Linde, Frank L; Lista, L; Liu, Z A; Lohmann, W; Longo, E; Lü, Y S; Lübelsmeyer, K; Luci, C; Luckey, D; Lugnier, L; Luminari, L; Lustermann, W; Ma Wen Gan; Maity, M; Malgeri, L; Malinin, A; Maña, C; Mangeol, D J J; Mans, J; Marchesini, P A; Marian, G; Martin, J P; Marzano, F; Massaro, G G G; Mazumdar, K; McNeil, R R; Mele, S; Merola, L; Meschini, M; Metzger, W J; Von der Mey, M; Mihul, A; Milcent, H; Mirabelli, G; Mnich, J; Mohanty, G B; Molnár, P; Monteleoni, B; Moulik, T; Muanza, G S; Muheim, F; Muijs, A J M; Musy, M; Napolitano, M; Nessi-Tedaldi, F; Newman, H; Niessen, T; Nisati, A; Nowak, H; Organtini, G; Oulianov, A; Palomares, C; Pandoulas, D; Paoletti, S; Paolucci, P; Paramatti, R; Park, H K; Park, I H; Pascale, G; Passaleva, G; Patricelli, S; Paul, T; Pauluzzi, M; Paus, C; Pauss, Felicitas; Pedace, M; Pensotti, S; Perret-Gallix, D; Petersen, B; Piccolo, D; Pierella, F; Pieri, M; Piroué, P A; Pistolesi, E; Plyaskin, V; Pohl, M; Pozhidaev, V; Postema, H; Pothier, J; Produit, N; Prokofev, D; Prokofiev, D O; Quartieri, J; Rahal-Callot, G; Rahaman, M A; Raics, P; Raja, N; Ramelli, R; Rancoita, P G; Raspereza, A V; Raven, G; Razis, P A; Ren, D; Rescigno, M; Reucroft, S; Van Rhee, T; Riemann, S; Riles, K; Robohm, A; Rodin, J; Roe, B P; Romero, L; Rosca, A; Rosier-Lees, S; Rubio, Juan Antonio; Ruschmeier, D; Rykaczewski, H; Saremi, S; Sarkar, S; Salicio, J; Sánchez, E; Sanders, M P; Sarakinos, M E; Schäfer, C; Shchegelskii, V; Schmidt-Kärst, S; Schmitz, D; Schopper, Herwig Franz; Schotanus, D J; Schwering, G; Sciacca, C; Sciarrino, D; Seganti, A; Servoli, L; Shevchenko, S; Shivarov, N; Shoutko, V; Shumilov, E; Shvorob, A V; Siedenburg, T; Son, D; Smith, B; Spillantini, P; Steuer, M; Stickland, D P; Stone, A; Stone, H; Stoyanov, B; Strässner, A; Sudhakar, K; Sultanov, G G; Sun, L Z; Suter, H; Swain, J D; Szillási, Z; Sztaricskai, T; Tang, X W; Tauscher, Ludwig; Taylor, L; Tellili, B; Timmermans, C; Ting, Samuel C C; Ting, S M; Tonwar, S C; Tóth, J; Tully, C; Tung, K L; Uchida, Y; Ulbricht, J; Valente, E; Vesztergombi, G; Vetlitskii, I; Vicinanza, D; Viertel, Gert M; Villa, S; Vivargent, M; Vlachos, S; Vodopyanov, I; Vogel, H; Vogt, H; Vorobev, I; Vorobyov, A A; Vorvolakos, A; Wadhwa, M; Wallraff, W; Wang, M; Wang, X L; Wang, Z M; Weber, A; Weber, M; Wienemann, P; Wilkens, H; Wu, S X; Wynhoff, S; Xia, L; Xu, Z Z; Yamamoto, J; Yang, B Z; Yang, C G; Yang, H J; Yang, M; Ye, J B; Yeh, S C; Zalite, A; Zalite, Yu; Zhang, Z P; Zhu, G Y; Zhu, R Y; Zichichi, A; Zilizi, G; Zöller, M

    2000-01-01

    We report on measurements of the inclusive production rate of $\\Sigma^+$ and $\\Sigma^0$ baryons in hadronic Z decays collected with the L3 detector at LEP. The $\\Sigma^+$ baryons are detected through the decay $\\Sigma^+ \\rightarrow {\\rm p} \\pi^0$, while the $\\Sigma^0$ baryons are detected via the decay mode $\\Sigma^0 \\rightarrow \\Lambda \\gamma$. The average numbers of $\\Sigma^+$ and $\\Sigma^0$ per hadronic Z decay are measured to be: \\begin{eqnarray*} \\left + \\left & = & 0.114 \\pm 0.011_{\\mbox{\\it \\small stat}} \\pm 0.009_{\\mbox{\\it \\small syst}} \\\\ \\left + \\left & = & 0.095 \\pm 0.015_{\\mbox{\\it \\small stat}} \\pm 0.013_{\\mbox{\\it \\small syst}} \\ \\mbox{.} \\end{eqnarray*} These rates are found to be higher than the predictions from Monte Carlo hadronization models and analytical parameterizations of strange baryon production.

  1. Staphylococcus aureus Transcriptome Architecture

    DEFF Research Database (Denmark)

    Mäder, Ulrike; Nicolas, Pierre; Depke, Maren;

    2016-01-01

    to their dependence on the RNA polymerase sigma factors SigA or SigB, and allow identification of new potential targets for several known transcription factors. In particular, this study revealed a relatively low abundance of antisense RNAs in S. aureus, where they overlap only 6% of the coding genes, and only 19...... antisense RNAs not co-transcribed with other genes were found. Promoter analysis and comparison with Bacillus subtilis links the small number of antisense RNAs to a less profound impact of alternative sigma factors in S. aureus. Furthermore, we revealed that Rho-dependent transcription termination...

  2. Six Sigma and Implementations of Six Sigma in Finance Sector

    OpenAIRE

    Gokhan Senol; Adem Anbar

    2010-01-01

    Quality is a one of the critical factors for achieving competitive advantage. Six sigma approach is a business strategy which usage has increased gradually in last years for quality improvement initiative. Although six sigma established by a manufacturing firm and it has been successfully implemented in many manufacturing firms, service firms have began to use six sigma for reducing cost, enhanced quality of service, increasing customer satisfaction and profitability. In this paper, six sigma...

  3. DESIGN FOR SIX SIGMA

    OpenAIRE

    Liem Ferryanto

    2007-01-01

    This article provides a step by step process of executing analytical or computer based Design for Six Sigma using a Sliding Door project as an example. It comprises of identification of Voice Of the Customer (VOC), transformation of VOC to what it is called Critical To Quality characteristics (CTQs), modeling of system transfers function, optimal and robust solutions, and tolerance design approach

  4. Supersymmetric Sigma Model geometry

    CERN Document Server

    Lindström, Ulf

    2012-01-01

    This is a review of how sigma models formulated in Superspace have become important tools for understanding geometry. Topics included are: The (hyper)k\\"ahler reduction; projective superspace; the generalized Legendre construction; generalized K\\"ahler geometry and constructions of hyperk\\"ahler metrics on Hermitean symmetric spaces.

  5. Supersymmetric Sigma Model Geometry

    OpenAIRE

    Ulf Lindström

    2012-01-01

    This is a review of how sigma models formulated in Superspace have become important tools for understanding geometry. Topics included are: The (hyper)k\\"ahler reduction; projective superspace; the generalized Legendre construction; generalized K\\"ahler geometry and constructions of hyperk\\"ahler metrics on Hermitean symmetric spaces.

  6. The role of sigmaB in the stress response of Gram-positive bacteria -- targets for food preservation and safety.

    Science.gov (United States)

    van Schaik, Willem; Abee, Tjakko

    2005-04-01

    The alternative sigma factor sigmaB modulates the stress response of several Gram-positive bacteria, including Bacillus subtilis and the food-borne human pathogens Bacillus cereus, Listeria monocytogenes and Staphylococcus aureus. In all these bacteria, sigmaB is responsible for the transcription of genes that can confer stress resistance to the vegetative cell. Recent findings indicate that sigmaB also plays an important role in antibiotic resistance, pathogenesis and cellular differentiation processes such as biofilm formation and sporulation. Although there are important differences in the regulation of sigmaB and in the set of genes regulated by sigmaB in B. subtilis, B. cereus, L. monocytogenes and S. aureus, there are also some conserved themes. A mechanistic understanding of the sigmaB activation processes and assessment of its regulon could provide tools for pathogen control and inactivation both in the food industry and clinical settings.

  7. Six Sigma and Implementations of Six Sigma in Finance Sector

    Directory of Open Access Journals (Sweden)

    Gokhan Senol

    2010-04-01

    Full Text Available Quality is a one of the critical factors for achieving competitive advantage. Six sigma approach is a business strategy which usage has increased gradually in last years for quality improvement initiative. Although six sigma established by a manufacturing firm and it has been successfully implemented in many manufacturing firms, service firms have began to use six sigma for reducing cost, enhanced quality of service, increasing customer satisfaction and profitability. In this paper, six sigma was examined in a view of finance sector and applications of six sigma within the finance sector were evaluated.

  8. Momentum Dependent Vertices $\\sigma \\gamma \\gamma$, $\\sigma \\rho \\gamma$ and $\\sigma \\rho \\rho$ : The NJL Scalar Hidden by Chiral Symmetry

    OpenAIRE

    Bajc, B.; Blin, A. H.; Hiller, B.; Nemes, M. C.; Rosina, M.

    1994-01-01

    We calculate the momentum dependence of three particle vertices $\\sigma \\gamma \\gamma$, $\\sigma \\rho \\gamma$ and $\\sigma \\rho \\rho$ in the context of a Nambu Jona Lasinio type model. We show how they influence the processes $\\gamma \\gamma \\rightarrow \\sigma \\rightarrow \\pi \\pi$, $\\rho \\rightarrow \\gamma \\sigma$ and $\\gamma \\gamma \\rightarrow \\rho \\rho$ and how chiral symmetry shadows the presence of the $\\sigma$.

  9. Gravitating $\\sigma$ Model Solitons

    OpenAIRE

    Kim, Yoonbai; Moon, Sei-Hoon

    1998-01-01

    We study axially symmetric static solitons of O(3) nonlinear $\\sigma$ model coupled to (2+1)-dimensional anti-de Sitter gravity. The obtained solutions are not self-dual under static metric. The usual regular topological lump solution cannot form a black hole even though the scale of symmetry breaking is increased. There exist nontopological solitons of half integral winding in a given model, and the corresponding spacetimes involve charged Ba$\\tilde n$ados-Teitelboim-Zanelli black holes with...

  10. DESIGN FOR SIX SIGMA

    Directory of Open Access Journals (Sweden)

    Liem Ferryanto

    2007-01-01

    Full Text Available This article provides a step by step process of executing analytical or computer based Design for Six Sigma using a Sliding Door project as an example. It comprises of identification of Voice Of the Customer (VOC, transformation of VOC to what it is called Critical To Quality characteristics (CTQs, modeling of system transfers function, optimal and robust solutions, and tolerance design approach

  11. Metodologie Six Sigma

    OpenAIRE

    Zajícová, Hana

    2010-01-01

    Bachelor thesis deals with the desription of the statistical foundations and individual steps of Six Sigma, which are descibed by the DMAIC model. The thesis focuses on statistical process control and control charts. The main goal is to evaluate the possible use of control charts for attributes, namely the control chart for fraction nonconforming or p-diagram and to describe its properties expressed by the operating characteristic (OC). The influence of the sample size on the OC curve is exam...

  12. Six Sigma pricing.

    Science.gov (United States)

    Sodhi, ManMohan S; Sodhi, Navdeep S

    2005-05-01

    Many companies are now good at managing costs and wringing out manufacturing efficiencies. The TQM movement and the disciplines of Six Sigma have seen to that. But the discipline so often brought to the cost side of the business equation is found far less commonly on the revenue side. The authors describe how a global manufacturer of industrial equipment, which they call Acme Incorporated, recently applied Six Sigma to one major revenue related activity--the price-setting process. It seemed to Acme's executives that pricing closely resembled many manufacturing processes. So, with the help of a Six Sigma black belt from manufacturing, a manager from Acme's pricing division recruited a team to carry out the five Six Sigma steps: Define what constitutes a defect. At Acme, a defect was an item sold at an unauthorized price. Gather data and prepare it for analysis. That involved mapping out the existing pricing-agreement process. Analyze the data. The team identified the ways in which people failed to carry out or assert effective control at each stage. Recommend modifications to the existing process. The team sought to decrease the number of unapproved prices without creating an onerous approval apparatus. Create controls. This step enabled Acme to sustain and extend the improvements in its pricing procedures. As a result of the changes, Acme earned dollar 6 million in additional revenue on one product line alone in the six months following implementation--money that went straight to the bottom line. At the same time, the company removed much of the organizational friction that had long bedeviled its pricing process. Other companies can benefit from Acme's experience as they look for ways to exercise price control without alienating customers.

  13. TonB-dependent outer membrane transport: going for Baroque?

    Science.gov (United States)

    Wiener, Michael C

    2005-08-01

    The import of essential organometallic micronutrients (such as iron-siderophores and vitamin B(12)) across the outer membrane of Gram-negative bacteria proceeds via TonB-dependent outer membrane transporters (TBDTs). The TBDT couples to the TonB protein, which is part of a multiprotein complex in the plasma (inner) membrane. Five crystal structures of TBDTs illustrate clearly the architecture of the protein in energy-independent substrate-free and substrate-bound states. In each of the TBDT structures, an N-terminal hatch (or plug or cork) domain occludes the lumen of a 22-stranded beta barrel. The manner by which substrate passes through the transporter (the "hatch-barrel problem") is currently unknown. Solution NMR and X-ray crystallographic structures of various TonB domains indicate a striking structural plasticity of this protein. Thermodynamic, biochemical and bacteriological studies of TonB and TBDTs indicate further that existing structures do not yet capture critical energy-dependent and in vivo conformations of the transport cycle. The reconciliation of structural and non-structural experimental data, and the unambiguous experimental elucidation of a detailed molecular mechanism of transport are current challenges for this field.

  14. Gravitating $\\sigma$ Model Solitons

    CERN Document Server

    Kim, Y; Kim, Yoonbai; Moon, Sei-Hoon

    1998-01-01

    We study axially symmetric static solitons of O(3) nonlinear $\\sigma$ model coupled to (2+1)-dimensional anti-de Sitter gravity. The obtained solutions are not self-dual under static metric. The usual regular topological lump solution cannot form a black hole even though the scale of symmetry breaking is increased. There exist nontopological solitons of half integral winding in a given model, and the corresponding spacetimes involve charged Ba$\\tilde n$ados-Teitelboim-Zanelli black holes without non-Abelian scalar hair.

  15. Observation of the Heavy Baryons Sigma b and Sigma b*.

    Science.gov (United States)

    Aaltonen, T; Abulencia, A; Adelman, J; Affolder, T; Akimoto, T; Albrow, M G; Amerio, S; Amidei, D; Anastassov, A; Anikeev, K; Annovi, A; Antos, J; Aoki, M; Apollinari, G; Arisawa, T; Artikov, A; Ashmanskas, W; Attal, A; Aurisano, A; Azfar, F; Azzi-Bacchetta, P; Azzurri, P; Bacchetta, N; Badgett, W; Barbaro-Galtieri, A; Barnes, V E; Barnett, B A; Baroiant, S; Bartsch, V; Bauer, G; Beauchemin, P-H; Bedeschi, F; Behari, S; Bellettini, G; Bellinger, J; Belloni, A; Benjamin, D; Beretvas, A; Beringer, J; Berry, T; Bhatti, A; Binkley, M; Bisello, D; Bizjak, I; Blair, R E; Blocker, C; Blumenfeld, B; Bocci, A; Bodek, A; Boisvert, V; Bolla, G; Bolshov, A; Bortoletto, D; Boudreau, J; Boveia, A; Brau, B; Brigliadori, L; Bromberg, C; Brubaker, E; Budagov, J; Budd, H S; Budd, S; Burkett, K; Busetto, G; Bussey, P; Buzatu, A; Byrum, K L; Cabrera, S; Campanelli, M; Campbell, M; Canelli, F; Canepa, A; Carillo, S; Carlsmith, D; Carosi, R; Carron, S; Casal, B; Casarsa, M; Castro, A; Catastini, P; Cauz, D; Cavalli-Sforza, M; Cerri, A; Cerrito, L; Chang, S H; Chen, Y C; Chertok, M; Chiarelli, G; Chlachidze, G; Chlebana, F; Cho, I; Cho, K; Chokheli, D; Chou, J P; Choudalakis, G; Chuang, S H; Chung, K; Chung, W H; Chung, Y S; Cilijak, M; Ciobanu, C I; Ciocci, M A; Clark, A; Clark, D; Coca, M; Compostella, G; Convery, M E; Conway, J; Cooper, B; Copic, K; Cordelli, M; Cortiana, G; Crescioli, F; Cuenca Almenar, C; Cuevas, J; Culbertson, R; Cully, J C; DaRonco, S; Datta, M; D'Auria, S; Davies, T; Dagenhart, D; de Barbaro, P; De Cecco, S; Deisher, A; De Lentdecker, G; De Lorenzo, G; Dell'Orso, M; Delli Paoli, F; Demortier, L; Deng, J; Deninno, M; De Pedis, D; Derwent, P F; Di Giovanni, G P; Dionisi, C; Di Ruzza, B; Dittmann, J R; D'Onofrio, M; Dörr, C; Donati, S; Dong, P; Donini, J; Dorigo, T; Dube, S; Efron, J; Erbacher, R; Errede, D; Errede, S; Eusebi, R; Fang, H C; Farrington, S; Fedorko, I; Fedorko, W T; Feild, R G; Feindt, M; Fernandez, J P; Field, R; Flanagan, G; Forrest, R; Forrester, S; Franklin, M; Freeman, J C; Furic, I; Gallinaro, M; Galyardt, J; Garcia, J E; Garberson, F; Garfinkel, A F; Gay, C; Gerberich, H; Gerdes, D; Giagu, S; Giannetti, P; Gibson, K; Gimmell, J L; Ginsburg, C; Giokaris, N; Giordani, M; Giromini, P; Giunta, M; Giurgiu, G; Glagolev, V; Glenzinski, D; Gold, M; Goldschmidt, N; Goldstein, J; Golossanov, A; Gomez, G; Gomez-Ceballos, G; Goncharov, M; González, O; Gorelov, I; Goshaw, A T; Goulianos, K; Gresele, A; Grinstein, S; Grosso-Pilcher, C; Grundler, U; Guimaraes da Costa, J; Gunay-Unalan, Z; Haber, C; Hahn, K; Hahn, S R; Halkiadakis, E; Hamilton, A; Han, B-Y; Han, J Y; Handler, R; Happacher, F; Hara, K; Hare, D; Hare, M; Harper, S; Harr, R F; Harris, R M; Hartz, M; Hatakeyama, K; Hauser, J; Hays, C; Heck, M; Heijboer, A; Heinemann, B; Heinrich, J; Henderson, C; Herndon, M; Heuser, J; Hidas, D; Hill, C S; Hirschbuehl, D; Hocker, A; Holloway, A; Hou, S; Houlden, M; Hsu, S-C; Huffman, B T; Hughes, R E; Husemann, U; Huston, J; Incandela, J; Introzzi, G; Iori, M; Ivanov, A; Iyutin, B; James, E; Jang, D; Jayatilaka, B; Jeans, D; Jeon, E J; Jindariani, S; Johnson, W; Jones, M; Joo, K K; Jun, S Y; Jung, J E; Junk, T R; Kamon, T; Karchin, P E; Kato, Y; Kemp, Y; Kephart, R; Kerzel, U; Khotilovich, V; Kilminster, B; Kim, D H; Kim, H S; Kim, J E; Kim, M J; Kim, S B; Kim, S H; Kim, Y K; Kimura, N; Kirsch, L; Klimenko, S; Klute, M; Knuteson, B; Ko, B R; Kondo, K; Kong, D J; Konigsberg, J; Korytov, A; Kotwal, A V; Kraan, A C; Kraus, J; Kreps, M; Kroll, J; Krumnack, N; Kruse, M; Krutelyov, V; Kubo, T; Kuhlmann, S E; Kuhr, T; Kulkarni, N P; Kusakabe, Y; Kwang, S; Laasanen, A T; Lai, S; Lami, S; Lammel, S; Lancaster, M; Lander, R L; Lannon, K; Lath, A; Latino, G; Lazzizzera, I; LeCompte, T; Lee, J; Lee, J; Lee, Y J; Lee, S W; Lefèvre, R; Leonardo, N; Leone, S; Levy, S; Lewis, J D; Lin, C; Lin, C S; Lindgren, M; Lipeles, E; Lister, A; Litvintsev, D O; Liu, T; Lockyer, N S; Loginov, A; Loreti, M; Lu, R-S; Lucchesi, D; Lujan, P; Lukens, P; Lungu, G; Lyons, L; Lys, J; Lysak, R; Lytken, E; Mack, P; MacQueen, D; Madrak, R; Maeshima, K; Makhoul, K; Maki, T; Maksimovic, P; Malde, S; Malik, S; Manca, G; Manousakis, A; Margaroli, F; Marginean, R; Marino, C; Marino, C P; Martin, A; Martin, M; Martin, V; Martínez, M; Martínez-Ballarín, R; Maruyama, T; Mastrandrea, P; Masubuchi, T; Matsunaga, H; Mattson, M E; Mazini, R; Mazzanti, P; McFarland, K S; McIntyre, P; McNulty, R; Mehta, A; Mehtala, P; Menzemer, S; Menzione, A; Merkel, P; Mesropian, C; Messina, A; Miao, T; Miladinovic, N; Miles, J; Miller, R; Mills, C; Milnik, M; Mitra, A; Mitselmakher, G; Miyamoto, A; Moed, S; Moggi, N; Mohr, B; Moon, C S; Moore, R; Morello, M; Movilla Fernandez, P; Mülmenstädt, J; Mukherjee, A; Muller, Th; Mumford, R; Murat, P; Mussini, M; Nachtman, J; Nagano, A; Naganoma, J; Nakamura, K; Nakano, I; Napier, A; Necula, V; Neu, C; Neubauer, M S; Nielsen, J; Nodulman, L; Norniella, O; Nurse, E; Oh, S H; Oh, Y D; Oksuzian, I; Okusawa, T; Oldeman, R; Orava, R; Osterberg, K; Pagliarone, C; Palencia, E; Papadimitriou, V; Papaikonomou, A; Paramonov, A A; Parks, B; Pashapour, S; Patrick, J; Pauletta, G; Paulini, M; Paus, C; Pellett, D E; Penzo, A; Phillips, T J; Piacentino, G; Piedra, J; Pinera, L; Pitts, K; Plager, C; Pondrom, L; Portell, X; Poukhov, O; Pounder, N; Prakoshyn, F; Pronko, A; Proudfoot, J; Ptohos, F; Punzi, G; Pursley, J; Rademacker, J; Rahaman, A; Ramakrishnan, V; Ranjan, N; Redondo, I; Reisert, B; Rekovic, V; Renton, P; Rescigno, M; Richter, S; Rimondi, F; Ristori, L; Robson, A; Rodrigo, T; Rogers, E; Rolli, S; Roser, R; Rossi, M; Rossin, R; Roy, P; Ruiz, A; Russ, J; Rusu, V; Saarikko, H; Safonov, A; Sakumoto, W K; Salamanna, G; Saltó, O; Santi, L; Sarkar, S; Sartori, L; Sato, K; Savard, P; Savoy-Navarro, A; Scheidle, T; Schlabach, P; Schmidt, E E; Schmidt, M A; Schmidt, M P; Schmitt, M; Schwarz, T; Scodellaro, L; Scott, A L; Scribano, A; Scuri, F; Sedov, A; Seidel, S; Seiya, Y; Semenov, A; Sexton-Kennedy, L; Sfyrla, A; Shalhout, S Z; Shapiro, M D; Shears, T; Shepard, P F; Sherman, D; Shimojima, M; Shochet, M; Shon, Y; Shreyber, I; Sidoti, A; Sinervo, P; Sisakyan, A; Slaughter, A J; Slaunwhite, J; Sliwa, K; Smith, J R; Snider, F D; Snihur, R; Soderberg, M; Soha, A; Somalwar, S; Sorin, V; Spalding, J; Spinella, F; Spreitzer, T; Squillacioti, P; Stanitzki, M; Staveris-Polykalas, A; St Denis, R; Stelzer, B; Stelzer-Chilton, O; Stentz, D; Strologas, J; Stuart, D; Suh, J S; Sukhanov, A; Sun, H; Suslov, I; Suzuki, T; Taffard, A; Takashima, R; Takeuchi, Y; Tanaka, R; Tecchio, M; Teng, P K; Terashi, K; Tesarek, R J; Thom, J; Thompson, A S; Thomson, E; Tipton, P; Tiwari, V; Tkaczyk, S; Toback, D; Tokar, S; Tollefson, K; Tomura, T; Tonelli, D; Torre, S; Torretta, D; Tourneur, S; Trischuk, W; Tsuno, S; Tu, Y; Turini, N; Ukegawa, F; Uozumi, S; Vallecorsa, S; van Remortel, N; Varganov, A; Vataga, E; Vazquez, F; Velev, G; Vellidis, C; Veramendi, G; Veszpremi, V; Vidal, M; Vidal, R; Vila, I; Vilar, R; Vine, T; Vogel, M; Vollrath, I; Volobouev, I; Volpi, G; Würthwein, F; Wagner, P; Wagner, R G; Wagner, R L; Wagner, J; Wagner, W; Wallny, R; Wang, S M; Warburton, A; Waters, D; Weinberger, M; Wester, W C; Whitehouse, B; Whiteson, D; Wicklund, A B; Wicklund, E; Williams, G; Williams, H H; Wilson, P; Winer, B L; Wittich, P; Wolbers, S; Wolfe, C; Wright, T; Wu, X; Wynne, S M; Yagil, A; Yamamoto, K; Yamaoka, J; Yamashita, T; Yang, C; Yang, U K; Yang, Y C; Yao, W M; Yeh, G P; Yoh, J; Yorita, K; Yoshida, T; Yu, G B; Yu, I; Yu, S S; Yun, J C; Zanello, L; Zanetti, A; Zaw, I; Zhang, X; Zhou, J; Zucchelli, S

    2007-11-16

    We report an observation of new bottom baryons produced in pp collisions at the Tevatron. Using 1.1 fb(-1) of data collected by the CDF II detector, we observe four Lambda b 0 pi+/- resonances in the fully reconstructed decay mode Lambda b 0-->Lambda c + pi-, where Lambda c+-->pK* pi+. We interpret these states as the Sigma b(*)+/- baryons and measure the following masses: m Sigma b+=5807.8 -2.2 +2.0(stat.)+/-1.7(syst.) MeV/c2, m Sigma b- =5815.2+/-1.0(stat.)+/-1.7(syst.) MeV/c2, and m(Sigma b*)-m(Sigma b)=21.2-1.9 +2.0(stat.)-0.3+0.4(syst.) MeV/c2.

  16. Staphylococcus aureus and Pregnancy

    Science.gov (United States)

    Staphylococcus aureus and Pregnancy In every pregnancy, a woman starts out with a 3-5% chance of having a ... This sheet talks about whether exposure to staphylococcus aureus may increase the risk for birth defects over ...

  17. Isolation and characterization of csbB, a gene controlled by Bacillus subtilis general stress transcription factor sigma B.

    Science.gov (United States)

    Akbar, S; Price, C W

    1996-10-24

    In the bacterium Bacillus subtilis (Bs), the alternative transcription factor sigma B is activated by environmental stresses to control the expression of a large set of unlinked genes. However, the range of physiological functions mediated by these sigma B-controlled genes is presently unknown. We report here that the newly identified gene csbB is under the dual control of a sigma B-dependent and a sigma B-independent promoter. The predicted product of csbB is a 329 residue protein containing two potential membrane-spanning segments in its C-terminal region, leading us to speculate that one class of sigma B-controlled genes acts to modify the cell envelope as part of the general stress response.

  18. Lean Six Sigma

    OpenAIRE

    N, Vivekananthamoorthy; S, ankar

    2011-01-01

    Методология Lean Six Sigma, которая идеально подходит для проектов, направленных на уменьшение объема потерь, длительности бизнес-циклов, их вариаций, а также для увеличения качества продукта, может служить основой для улучшения бизнес-процессов.

  19. Six sigma for revenue retrieval.

    Science.gov (United States)

    Plonien, Cynthia

    2013-01-01

    Deficiencies in revenue retrieval due to failures in obtaining charges have contributed to a negative bottom line for numerous hospitals. Improving documentation practices through a Six Sigma process improvement initiative can minimize opportunities for errors through reviews and instill structure for compliance and consistency. Commitment to the Six Sigma principles with continuous monitoring of outcomes and constant communication of results to departments, management, and payers is a strong approach to reducing the financial impact of denials on an organization's revenues and expenses. Using Six Sigma tools can help improve the organization's financial performance not only for today, but also for health care's uncertain future.

  20. Spectra of coset sigma models

    Energy Technology Data Exchange (ETDEWEB)

    Candu, Constantin [Institut fuer Theoretische Physik, Zuerich (Switzerland); Mitev, Vladimir [Humboldt-Universitaet, Berlin (Germany). Inst. fuer Mathematik; Humboldt-Universitaet, Berlin (Germany). Inst. fuer Physik; Schomerus, Volker [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany). Theory Group

    2013-08-15

    We compute the complete 1-loop spectrum of anomalous dimensions for the bulk fields of non-linear sigma models on symmetric coset (super)spaces G/H, both with and without world-sheet supersymmetry. In addition, we provide two new methods for the construction of partition functions in the infinite radius limit and demonstrate their efficiency in the case of (super)sphere sigma models. Our results apply to a large number of target spaces including superspheres and superprojective spaces such as the N=2 sigma model on CP{sup 3} {sup vertical} {sup stroke} {sup 4}.

  1. Staphylococcus aureus toxins.

    Science.gov (United States)

    Otto, Michael

    2014-02-01

    Staphylococcus aureus is a dangerous pathogen that causes a variety of severe diseases. The virulence of S. aureus is defined by a large repertoire of virulence factors, among which secreted toxins play a preeminent role. Many S. aureus toxins damage biological membranes, leading to cell death. In particular, S. aureus produces potent hemolysins and leukotoxins. Among the latter, some were recently identified to lyse neutrophils after ingestion, representing an especially powerful weapon against bacterial elimination by innate host defense. Furthermore, S. aureus secretes many factors that inhibit the complement cascade or prevent recognition by host defenses. Several further toxins add to this multi-faceted program of S. aureus to evade elimination in the host. This review will give an overview over S. aureus toxins focusing on recent advances in our understanding of how leukotoxins work in receptor-mediated or receptor-independent fashions.

  2. Running Head: Implementing Six Sigma Efforts

    Science.gov (United States)

    Lindsay, Jamie Eleaitia Mae

    2005-01-01

    Six Sigma is an organization wide program that provides common set of goals, language, and methodology for improving the overall quality of the processes within the organization (Davis & Heineke 2004). Six Sigma main concern is for the customer. What will the customers want? Need? Six Sigma has a model that helps Sigma get implemented DMAIC model…

  3. The extracytoplasmic function (ECF) sigma factors.

    Science.gov (United States)

    Helmann, John D

    2002-01-01

    Bacterial sigma (sigma) factors are an essential component of RNA polymerase and determine promoter selectivity. The substitution of one sigma factor for another can redirect some or all of the RNA polymerase in a cell to activate the transcription of genes that would otherwise be silent. As a class, alternative sigma factors play key roles in coordinating gene transcription during various stress responses and during morphological development. The extracytoplasmic function (ECF) sigma factors are small regulatory proteins that are quite divergent in sequence relative to most other sigma factors. Many bacteria, particularly those with more complex genomes, contain multiple ECF sigma factors and these regulators often outnumber all other types of sigma factor combined. Examples include Bacillus subtilis (7 ECF sigma factors), Mycobacterium tuberculosis (10), Caulobacter crescentus (13), Pseudomonas aeruginosa (approximately 19), and Streptomyces coelicolor (approximately 50). The roles and mechanisms of regulation for these various ECF sigma factors are largely unknown, but significant progress has been made in selected systems. As a general trend, most ECF sigma factors are cotranscribed with one or more negative regulators. Often, these include a transmembrane protein functioning as an anti-sigma factor that binds, and inhibits, the cognate sigma factor. Upon receiving a stimulus from the environment, the sigma factor is released and can bind to RNA polymerase to stimulate transcription. In many ways, these anti-sigma:sigma pairs are analogous to the more familiar two-component regulatory systems consisting of a transmembrane histidine protein kinase and a DNA-binding response regulator. Both are mechanisms of coordinating a cytoplasmic transcriptional response to signals perceived by protein domains external to the cell membrane. Here, I review current knowledge of some of the better characterized ECF sigma factors, discuss the variety of experimental approaches

  4. Spectra of conformal sigma models

    Energy Technology Data Exchange (ETDEWEB)

    Tlapak, Vaclav

    2015-04-15

    In this thesis the spectra of conformal sigma models defined on (generalized) symmetric spaces are analysed. The spaces where sigma models are conformal without the addition of a Wess-Zumino term are supermanifolds, in other words spaces that include fermionic directions. After a brief review of the general construction of vertex operators and the background field expansion, we compute the diagonal terms of the one-loop anomalous dimensions of sigma models on semi-symmetric spaces. We find that the results are formally identical to the symmetric case. However, unlike for sigma models on symmetric spaces, off diagonal terms that lead to operator mixing are also present. These are not computed here. We then present a detailed analysis of the one-loop spectrum of the supersphere S{sup 3} {sup vertical} {sup stroke} {sup 2} sigma model as one of the simplest examples. The analysis illustrates the power and simplicity of the construction. We use this data to revisit a duality with the OSP(4 vertical stroke 2) Gross-Neveu model that was proposed by Candu and Saleur. With the help of a recent all-loop result for the anomalous dimension of (1)/(2)BPS operators of Gross-Neveu models, we are able to recover the entire zero-mode spectrum of the supersphere model. We also argue that the sigma model constraints and its equations of motion are implemented correctly in the Gross-Neveu model, including the one-loop data. The duality is further supported by a new all-loop result for the anomalous dimension of the ground states of the sigma model. However, higher-gradient operators cannot be completely recovered. It is possible that this discrepancy is related to a known instability of the sigma model. The instability of sigma models is due to symmetry preserving high-gradient operators that become relevant at arbitrarily small values of the coupling. This feature has been observed long ago in one-loop calculations of the O(N)-vector model and soon been realized to be a generic

  5. Bethe Ansatz in Stringy Sigma Models

    OpenAIRE

    Klose, T.; Zarembo, K.

    2006-01-01

    We compute the exact S-matrix and give the Bethe ansatz solution for three sigma-models which arise as subsectors of string theory in AdS(5)xS(5): Landau-Lifshitz model (non-relativistic sigma-model on S(2)), Alday-Arutyunov-Frolov model (fermionic sigma-model with su(1|1) symmetry), and Faddeev-Reshetikhin model (string sigma-model on S(3)xR).

  6. Lean Six Sigma in financial services

    NARCIS (Netherlands)

    de Koning, H.; Does, R.J.M.M.; Bisgaard, S.

    2008-01-01

    Lean Thinking and Six Sigma are typically considered as separate approaches to process innovation, with complementary strengths. When combined as Lean Six Sigma, this approach provides a unified framework for systematically developing innovations. Lean Six Sigma can also bring about significant resu

  7. The sausage sigma model revisited

    Science.gov (United States)

    Suneeta, Vardarajan

    2015-06-01

    Fateev’s sausage sigma models in two and three dimensions are known to be integrable. We study their stability under renormalization group (RG) flow in the target space by using results from the mathematics of Ricci flow. We show that the three-dimensional sausage is unstable, whereas the two-dimensional sausage appears to be stable at least at leading order as it approaches the sphere. We speculate that the stability results obtained are linked to the classification of ancient solutions to Ricci flow (i.e., sigma models that are nonperturbative in the infrared regime) in two and three dimensions. We also describe a class of perturbations of the three-dimensional sausage (with the same continuous symmetries) which remarkably decouple. This indicates that there could be a new solution to RG flow, which is described at least perturbatively as a deformation of the sausage.

  8. Topological sigma models on supermanifolds

    Science.gov (United States)

    Jia, Bei

    2017-02-01

    This paper concerns constructing topological sigma models governing maps from semirigid super Riemann surfaces to general target supermanifolds. We define both the A model and B model in this general setup by defining suitable BRST operators and physical observables. Using supersymmetric localization, we express correlation functions in these theories as integrals over suitable supermanifolds. In the case of the A model, we obtain an integral over the supermoduli space of "superinstantons". The language of supergeometry is used extensively throughout this paper.

  9. Topological Sigma Models On Supermanifolds

    CERN Document Server

    Jia, Bei

    2016-01-01

    This paper concerns constructing topological sigma models governing maps from semirigid super Riemann surfaces to general target supermanifolds. We define both the A model and B model in this general setup by defining suitable BRST operators and physical observables. Using supersymmetric localization, we express correlation functions in these theories as integrals over suitable supermanifolds. In the case of the A model, we obtain an integral over the supermoduli space of "superinstantons". The language of supergeometry is used extensively throughout this paper.

  10. Lean six sigma in healthcare.

    Science.gov (United States)

    de Koning, Henk; Verver, John P S; van den Heuvel, Jaap; Bisgaard, Soren; Does, Ronald J M M

    2006-01-01

    Healthcare, as with any other service operation, requires systematic innovation efforts to remain competitive, cost efficient, and up-to-date. This article outlines a methodology and presents examples to illustrate how principles of Lean Thinking and Six Sigma can be combined to provide an effective framework for producing systematic innovation efforts in healthcare. Controlling healthcare cost increases, improving quality, and providing better healthcare are some of the benefits of this approach.

  11. The sausage sigma model revisited

    CERN Document Server

    Suneeta, Vardarajan

    2014-01-01

    Fateev's sausage sigma models in two and three dimensions are known to be integrable. We study their stability under RG flow in the target space by using results from the mathematics of Ricci flow. We show that the three dimensional sausage is unstable, whereas the two dimensional sausage appears to be stable at least at leading order as it approaches the sphere. The $n$-sphere, corresponding to the integrable O(n) sigma model, is geometrically stable and an attractor for nearby solutions to RG flow. We speculate that the stability results obtained seem to be linked to the classification of ancient solutions to Ricci flow (i.e., sigma models which are asymptotically free in the UV and nontrivial in the IR) in two and three dimensions. We also describe a class of perturbations of the three dimensional sausage (with the same continuous symmetries) which remarkably decouple. This indicates that there could be a new solution to RG flow which is described at least perturbatively as a deformation of the sausage.

  12. The sigma Orionis substellar population

    CERN Document Server

    Barrado y Navascués, D; Mundt, R; Martín, E L; Rebolo, R; Zapatero-Osorio, M R; Bailer-Jones, C A L; Navascu\\'es, David Barrado y; Mundt, Reinhard; Mart\\'{\\i}n, Eduardo L.; Rebolo, Rafael; Osorio, Mar\\'{\\i}a Rosa Zapatero; Bailer-Jones, Coryn A.L.

    2003-01-01

    VLT/FORS spectroscopy and 2MASS near-infrared photometry, together with previously known data, have been used to establish the membership and the properties of a sample of low-mass candidate members of the sigma Orionis cluster with masses spanning from 1 Msun down to about 0.013 Msun (i.e., deuterium-burning mass limit). We have observed K-band infrared excess and remarkably intense H(alpha) emission in various cluster members, which, in addition to the previously detected forbidden emision lines and the presence of LiI in absorption at 6708 A, have allowed us to tentatively classify sigma Orionis members as classical or weak-line TTauri stars and substellar analogs. Variability of the H(alpha) line has been investigated and detected in some objects. Based on the K-band infrared excesses and the intensity of H(alpha) emission, we estimate that the minimum disk frequency of the sigma Orionis low-mass population is in the range 5-12%.

  13. Sigma-class glutathione transferases.

    Science.gov (United States)

    Flanagan, Jack U; Smythe, Mark L

    2011-05-01

    Mammalian cytosolic glutathione transferases (GSTs) can be grouped into seven classes. Of these, the sigma class is also widely distributed in nature, with isoforms found in both vertebrates and invertebrates. It contains examples of proteins that have evolved specialized functions, such as the cephalopod lens S-crystallins, the mammalian hematopoietic prostaglandin D(2) synthase, and the helminth 28-kDa antigen. In mammals, the sigma-class GST has both anti- and proinflammatory functions, depending on the type of immune response, and an immunomodulatory function is also associated with the enzyme from helminth parasites. In the fly, it is associated with a specific detoxication activity toward lipid oxidation products. Mice genetically depleted of the sigma-class GST, or transgenically overexpressing it, have provided insight into the physiological roles of the GST. Inhibitors of the mammalian enzyme developed by structure-based methods are effective in controlling allergic response. This review covers the structure, function, and pharmacology of vertebrate and invertebrate GSTs.

  14. Sign ambiguity in the K Sigma channel

    CERN Document Server

    Anisovich, A V; Nikonov, V A; Sarantsev, A V; Thoma, U

    2013-01-01

    Ambiguities of the signs of $N\\to \\Sigma K$ coupling constants are studied in a multichannel partial wave analysis of a large body of pion and photo-induced reactions. It is shown that the signs are not free from some ambiguities, and further experimental data are needed. Data on the reactions $\\pi^+p\\to \\Sigma^+K^+$ and $\\gamma p\\to K^+\\Sigma^0$ define rather well the isospin 3/2 contributions to these channels. However the lack of information on polarization observables for the reactions $\\pi^-p\\to \\Sigma^0K^0$, $\\pi^-p\\to \\Sigma^-K^+$ and $\\gamma p\\to K^0\\Sigma^+$ does not allow us to fix uniquely the signs of $N\\to \\Sigma K$ coupling constants. As a consequence, also the contributions of nucleon resonances to these channels remain uncertain.

  15. Bacterial Sigma Factors and Anti-Sigma Factors: Structure, Function and Distribution.

    Science.gov (United States)

    Paget, Mark S

    2015-06-26

    Sigma factors are multi-domain subunits of bacterial RNA polymerase (RNAP) that play critical roles in transcription initiation, including the recognition and opening of promoters as well as the initial steps in RNA synthesis. This review focuses on the structure and function of the major sigma-70 class that includes the housekeeping sigma factor (Group 1) that directs the bulk of transcription during active growth, and structurally-related alternative sigma factors (Groups 2-4) that control a wide variety of adaptive responses such as morphological development and the management of stress. A recurring theme in sigma factor control is their sequestration by anti-sigma factors that occlude their RNAP-binding determinants. Sigma factors are then released through a wide variety of mechanisms, often involving branched signal transduction pathways that allow the integration of distinct signals. Three major strategies for sigma release are discussed: regulated proteolysis, partner-switching, and direct sensing by the anti-sigma factor.

  16. Cohomological reduction of sigma models

    Energy Technology Data Exchange (ETDEWEB)

    Candu, Constantin; Mitev, Vladimir; Schomerus, Volker [DESY, Hamburg (Germany). Theory Group; Creutzig, Thomas [North Carolina Univ., Chapel Hill, NC (United States). Dept. of Physics and Astronomy

    2010-01-15

    This article studies some features of quantum field theories with internal supersymmetry, focusing mainly on 2-dimensional non-linear sigma models which take values in a coset superspace. It is discussed how BRST operators from the target space super- symmetry algebra can be used to identify subsectors which are often simpler than the original model and may allow for an explicit computation of correlation functions. After an extensive discussion of the general reduction scheme, we present a number of interesting examples, including symmetric superspaces G/G{sup Z{sub 2}} and coset superspaces of the form G/G{sup Z{sub 4}}. (orig.)

  17. Sigma Factors for Cyanobacterial Transcription

    Directory of Open Access Journals (Sweden)

    Sousuke Imamura

    2009-04-01

    Full Text Available Cyanobacteria are photosynthesizing microorganisms that can be used as a model for analyzing gene expression. The expression of genes involves transcription and translation. Transcription is performed by the RNA polymerase (RNAP holoenzyme, comprising a core enzyme and a sigma (σ factor which confers promoter selectivity. The unique structure, expression, and function of cyanobacterial σ factors (and RNAP core subunits are summarized here based on studies, reported previously. The types of promoter recognized by the σ factors are also discussed with regard to transcriptional regulation.

  18. Conserved and Variable Functions of the sigma(E Stress Response in Related Genomes.

    Directory of Open Access Journals (Sweden)

    2005-12-01

    Full Text Available Bacteria often cope with environmental stress by inducing alternative sigma (sigma factors, which direct RNA polymerase to specific promoters, thereby inducing a set of genes called a regulon to combat the stress. To understand the conserved and organism-specific functions of each sigma, it is necessary to be able to predict their promoters, so that their regulons can be followed across species. However, the variability of promoter sequences and motif spacing makes their prediction difficult. We developed and validated an accurate promoter prediction model for Escherichia coli sigma(E, which enabled us to predict a total of 89 unique sigma(E-controlled transcription units in E. coli K-12 and eight related genomes. sigma(E controls the envelope stress response in E. coli K-12. The portion of the regulon conserved across genomes is functionally coherent, ensuring the synthesis, assembly, and homeostasis of lipopolysaccharide and outer membrane porins, the key constituents of the outer membrane of Gram-negative bacteria. The larger variable portion is predicted to perform pathogenesis-associated functions, suggesting that sigma(E provides organism-specific functions necessary for optimal host interaction. The success of our promoter prediction model for sigma(E suggests that it will be applicable for the prediction of promoter elements for many alternative sigma factors.

  19. Lean Six Sigma in financial services

    OpenAIRE

    Koning, H.; Does, R.J.M.M.; Bisgaard, S.

    2008-01-01

    Lean Thinking and Six Sigma are typically considered as separate approaches to process innovation, with complementary strengths. When combined as Lean Six Sigma, this approach provides a unified framework for systematically developing innovations. Lean Six Sigma can also bring about significant results and breakthrough improvements in financial services, as demonstrated with four case studies from Dutch multinational insurance companies. These cases demonstrate the importance of incremental i...

  20. Applying Sigma Metrics to Reduce Outliers.

    Science.gov (United States)

    Litten, Joseph

    2017-03-01

    Sigma metrics can be used to predict assay quality, allowing easy comparison of instrument quality and predicting which tests will require minimal quality control (QC) rules to monitor the performance of the method. A Six Sigma QC program can result in fewer controls and fewer QC failures for methods with a sigma metric of 5 or better. The higher the number of methods with a sigma metric of 5 or better, the lower the costs for reagents, supplies, and control material required to monitor the performance of the methods.

  1. Bacterial Sigma Factors and Anti-Sigma Factors: Structure, Function and Distribution

    OpenAIRE

    Paget, Mark S.

    2015-01-01

    Sigma factors are multi-domain subunits of bacterial RNA polymerase (RNAP) that play critical roles in transcription initiation, including the recognition and opening of promoters as well as the initial steps in RNA synthesis. This review focuses on the structure and function of the major sigma-70 class that includes the housekeeping sigma factor (Group 1) that directs the bulk of transcription during active growth, and structurally-related alternative sigma factors (Groups 2–4) that control ...

  2. Sigma Receptors in Oncology : Therapeutic and Diagnostic Applications of Sigma Ligands

    NARCIS (Netherlands)

    van Waarde, Aren; Rybczynska, Anna A.; K. Ramakrishnan, Nisha; Ishiwata, Kiichi; Elsinga, Philip H.; Dierckx, Rudi A. J. O.

    2010-01-01

    Sigma receptors (subtypes sigma-1 and sigma-2) are a unique class of binding sites expressed throughout the mammalian body. The endogenous ligand for these sites has not been identified, but steroid hormones (particularly progesterone), sphingolipid-derived amines and N,N-dimethyltryptamine can bind

  3. Exploring the Supersymmetric $\\sigma$ Model

    CERN Document Server

    De Oliveira-Imbiriba, B C

    1999-01-01

    The purpose of this work is to present some basic concepts about the non-linear sigma model in a simple and direct way. We start with showing the bosonic model and the Wess-Zumino-Witten term, making some comments about its topological nature, and its association with the torsion. It is also shown that to cancel the quantum conformal anomaly the model should obey the Einstein equations. We provide a quick introduction about supersymmetry in chapter 2 to help the understanding the supersymmetric extension of the model. In the last chapter we present the supersymmetric model and its equations of motion. Finally we work-out the two-supersymmetry case, introducing the chiral as well as the twisted chiral fields, expliciting the very specific $SU(2)\\otimes U(1)$ case.

  4. TA-55 and Sigma Overview

    Energy Technology Data Exchange (ETDEWEB)

    Spearing, Dane Robert [Los Alamos National Lab. (LANL), Los Alamos, NM (United States). Safeguards Science and Technology Group (NEN-1)

    2016-11-29

    These are slides from a facility overview presentation for visiting agencies to Los Alamos National Laboratory (LANL). The TA-55 Plutonium Facility (PF-4) is discussed in detail. PF-4 is a unique resource for US plutonium programs. The basic design is flexible and has adapted to changing national needs. It is a robust facility with strong safety and security implementation. It supports a variety of national programs. It will continue for many years into the future. Sigma is then discussed in detail, which handles everything from hydrogen to uranium. It has been in long term service to the Nation (nearly 60 years). It has a flexible authorization basis to handle almost the entire periodic table. It has a wide breadth of prototyping and characterization capabilities. It has integrated program and line management.

  5. Geometry of Membrane Sigma Models

    CERN Document Server

    Vysoky, Jan

    2015-01-01

    String theory still remains one of the promising candidates for a unification of the theory of gravity and quantum field theory. One of its essential parts is relativistic description of moving multi-dimensional objects called membranes (or p-branes) in a curved spacetime. On the classical field theory level, they are described by an action functional extremalising the volume of a manifold swept by a propagating membrane. This and related field theories are collectively called membrane sigma models. Differential geometry is an important mathematical tool in the study of string theory. It turns out that string and membrane backgrounds can be conveniently described using objects defined on a direct sum of tangent and cotangent bundles of the spacetime manifold. Mathematical field studying such object is called generalized geometry. Its integral part is the theory of Leibniz algebroids, vector bundles with a Leibniz algebra bracket on its module of smooth sections. Special cases of Leibniz algebroids are better ...

  6. Lean Six Sigma in a hospital

    NARCIS (Netherlands)

    van den Heuvel, J.; Does, R.J.M.M.; de Koning, H.

    2006-01-01

    Abstract Hospitals today face major challenges. Patients demand quality of care to be improved continuously. Health insurance companies demand the lowest possible prices. Lean Six Sigma is a program that can help healthcare providers to achieve these (seemingly) conflicting goals. Lean Six Sigma is

  7. Six Sigma als blauwdruk voor de kenniseconomie.

    NARCIS (Netherlands)

    de Mast, J.; Does, R.J.M.M.

    2005-01-01

    Abstract Six Sigma is zo langzamerhand een niet weg te denken programma voor kwaliteits- en efficiencyverbeteringen. Het heeft met name voor enorme successen gezorgd in productiebedrijven. Six Sigma ligt ook onder vuur: het zou een trend zijn die voorbij gaat. De auteurs van dit artikel zijn het van

  8. Integrating the Many Facets of Six Sigma

    NARCIS (Netherlands)

    de Mast, J.

    2007-01-01

    We seek to provide a unified characterization of Six Sigma by studying the phenomenon from the perspectives of business economics, organizational theory, competitive strategy and industrial statistics, and we pinpoint its core methodological principles. We describe Six Sigma as a prescriptive framew

  9. De praktijk van Lean Six Sigma

    NARCIS (Netherlands)

    Does, R.J.M.M.; de Koning, H.

    2008-01-01

    Zowel Lean als Six Sigma zijn benaderingen van kwaliteits- en efficiëntieverbetering die op dit moment sterk in de belangstelling staan van zowel de industrie als de dienstverlening. Lean Six Sigma integreert beide benaderingen. Ze wordt door sommigen gezien als panacee voor alle mogelijke organisat

  10. THE LEAN AND SIX SIGMA SINERGY

    Directory of Open Access Journals (Sweden)

    Mirko Sokovic

    2008-12-01

    Full Text Available Many organizations, dealing with continuous improvement methods, have realized that Lean and Six Sigma methodologies complement each other. Lean manufacturing focuses on the remova l of waste so that all processes in the total system add value from the customers' perspectives. The main emphasis of Six Sigma is the application of statistical tools in a disciplined manner, which requires data-driven decision-making. The integration of Lean and Six Sigma provides a synergetic effect, a rapid process improvement strategy for attaining organizational goals. When separated, Lean manufacturing cannot bring a process under statistical control, and Six Sigma cannot dramatically improve cycle time or reduce invested capital. Together, synergistic qualities are created to maximize the potential for a process improvement. The paper deals with Lean and Six Sigma principles and approaches used in modern manufacturing for process improvements, and bring forward benefits that are gained when these two methodologies are integrated.

  11. Sigma-1 Receptor in Motoneuron Disease.

    Science.gov (United States)

    Mancuso, Renzo; Navarro, Xavier

    2017-01-01

    Amyotrophic Lateral Sclerosis (ALS ) is a neurodegenerative disease affecting spinal cord and brain motoneurons , leading to paralysis and early death. Multiple etiopathogenic mechanisms appear to contribute in the development of ALS , including glutamate excitotoxicity, oxidative stress , protein misfolding, mitochondrial defects, impaired axonal transport, inflammation and glial cell alterations. The Sigma-1 receptor is highly expressed in motoneurons of the spinal cord, particularly enriched in the endoplasmic reticulum (ER) at postsynaptic cisternae of cholinergic C-terminals. Several evidences point to participation of Sigma-1R alterations in motoneuron degeneration. Thus, mutations of the transmembrane domain of the Sigma-1R have been described in familial ALS cases. Interestingly, Sigma-1R KO mice display muscle weakness and motoneuron loss. On the other hand, Sigma-1R agonists promote neuroprotection and neurite elongation through activation of protein kinase C on motoneurons in vitro and in vivo after ventral root avulsion. Remarkably, treatment of SOD1 mice, the most usual animal model of ALS , with Sigma-1R agonists resulted in significantly enhanced motoneuron function and preservation, and increased animal survival. Sigma-1R activation also reduced microglial reactivity and increased the glial expression of neurotrophic factors. Two main interconnected mechanisms seem to underlie the effects of Sigma-1R manipulation on motoneurons: modulation of neuronal excitability and regulation of calcium homeostasis. In addition, Sigma-1R also contributes to regulating protein degradation, and reducing oxidative stress. Therefore, the multi-functional nature of the Sigma-1R represents an attractive target for treating aspects of ALS and other motoneuron diseases .

  12. Staphylococcus aureus bacteremia.

    Science.gov (United States)

    Jensen, Allan Garlik

    2003-11-01

    Staphylococcus aureus bacteremia (SAB) is still associated with a high mortality, and knowledge on risk factors and the clinical and the therapeutic aspects of SAB is still limited. This thesis focuses on the clinical aspects of SAB and its metastatic infections. In a study of all patients with bacteremia in Copenhagen County October 1992 through April 1993 (study I) we emphasized previous findings, that S. aureus is one of the most frequent pathogens in bacteremia, and in a case control study also in Copenhagen County 1994-95 (study II) we demonstrated, that not only an inserted central venous catheter and nasal S. aureus carriage but also hyponatremia and anemia are important risk factors for hospital-acquired SAB (study II). Studies on the treatment of SAB have pointed out, that the eradication of a primary is important, but there are only limited clinical studies dealing with antibiotic treatment. By logistic regression analysis, we were able to demonstrate that focus eradication is essential, but also that treatment with dicloxacillin 1 g x 4 or 2 g x 3 are superior to 1 g x 3 (studie III), indicating that the time for serum concentration above the Minimal Inhibitory Concentration (MIC) for the bacteria plays a role in the outcome of SAB treatment. S. aureus osteomyelitis secondary to SAB is frequently observed. No other countries, however, have a centralized registration, which make it possible to evaluate a large number of these patients. Since 1960, The Staphylococcal Laboratory, Statens Serum Institut in Copenhagen, has registrated selected clinical informations from nearly all patients with positive blood cultures of S. aureus. Based on this registration, we were able to show an increased number of S. aureus osteomyelitis among older patients and a decreased number of S. aureus osteomyelitis of femur and tibia among younger infants in the period 1980-90 (study IV). By reviewing the records of a large number of patients with vertebral S. aureus

  13. TLR-mediated NF-kB-dependent cytokine production is differently affected by HIV therapeutics

    DEFF Research Database (Denmark)

    Melchjorsen, Jesper; Paludan, Søren Riis; Mogensen, Trine

      Pathogen-recognizing Toll-like receptors 2 (TLR2) and TLR4 are known to recognize a number of pathogens, including E.Coli, S. Pneumonia and N. Meningococcus. We have studied whether a number of HIV therapeutics affect immediate proinflammatory cytokine responses in cell cultures. Preliminary...... results suggest an opposing effect of the drugs Tenofovir and Retrovir (AZT) on TLR-mediated production of NF-kappaB-dependent proinflammatory cytokines. We present data on the mechanisms behind the drug-mediated remodeling of innate immune activation and how the drugs effect early host...

  14. Higher-Dimensional Geometric $\\sigma$-Models

    CERN Document Server

    Vasilic, M

    1999-01-01

    Geometric $\\sigma$-models have been defined as purely geometric theories of scalar fields coupled to gravity. By construction, these theories possess arbitrarily chosen vacuum solutions. Using this fact, one can build a Kaluza--Klein geometric $\\sigma$-model by specifying the vacuum metric of the form $M^4\\times B^d$. The obtained higher dimensional theory has vanishing cosmological constant but fails to give massless gauge fields after the dimensional reduction. In this paper, a modified geometric $\\sigma$-model is suggested, which solves the above problem.

  15. SIGMA WEB INTERFACE FOR REACTOR DATA APPLICATIONS

    Energy Technology Data Exchange (ETDEWEB)

    Pritychenko,B.; Sonzogni, A.A.

    2010-05-09

    We present Sigma Web interface which provides user-friendly access for online analysis and plotting of the evaluated and experimental nuclear reaction data stored in the ENDF-6 and EXFOR formats. The interface includes advanced browsing and search capabilities, interactive plots of cross sections, angular distributions and spectra, nubars, comparisons between evaluated and experimental data, computations for cross section data sets, pre-calculated integral quantities, neutron cross section uncertainties plots and visualization of covariance matrices. Sigma is publicly available at the National Nuclear Data Center website at http://www.nndc.bnl.gov/sigma.

  16. Measurement of Natural Widths of Sigma-c-0 and Sigma-c-++ Baryons

    CERN Document Server

    Link, J M; Reyes, M; Yager, P M; Anjos, J C; Bediaga, I; Göbel, C; Magnin, J; Massafferri, A; De Miranda, J M; Pepe, I M; Dos Reis, A C; Carrillo, S; Casimiro, E; Cuautle, E; Sánchez-Hernández, A; Uribe, C; Vázquez, F; Agostino, L; Cinquini, L; Cumalat, J P; O'Reilly, B; Ramírez, J E; Segoni, I; Butler, J N; Cheung, H W K; Chiodini, G; Gaines, I; Garbincius, P H; Garren, L A; Gottschalk, E; Kasper, P H; Kreymer, A E; Kutschke, R; Bianco, S; Fabbri, Franco Luigi; Zallo, A; Cawlfield, C; Kim, D Y; Rahimi, A; Wiss, J; Gardner, R; Kryemadhi, A; Chung, Y S; Kang, J S; Ko, B R; Kwak, J W; Lee, K B; Park, H; Alimonti, G; Barberis, S; Boschini, M; D'Angelo, P; Di Corato, M; Dini, P; Edera, L; Erba, S; Giammarchi, M; Inzani, P; Leveraro, F; Malvezzi, S; Menasce, D; Mezzadri, M; Milazzo, L; Moroni, L; Pedrini, D; Pontoglio, C; Prelz, F; Rovere, M; Sala, S; Davenport, T F; Arena, V; Boca, G; Bonomi, G; Gianini, G; Liguori, G; Merlo, M M; Pantea, D; Ratti, S P; Riccardi, C; Vitulo, P; Hernández, H; López, A M; Méndez, H; Méndez, L; Montiel, E; Olaya, D; Paris, A; Quinones, J; Rivera, C; Xiong, W; Zhang, Y; Wilson, J R; Cho, K; Handler, T; Mitchell, R; Engh, D; Hosack, M; Johns, W E; Nehring, M; Sheldon, P D; Stenson, K; Vaandering, E W; Webster, M; Sheaff, M

    2002-01-01

    In this paper we present a measurement of the natural widths of $\\Sigma_c^0$ and $\\Sigma_c^{++}$. Using data from the FOCUS experiment, we find $\\Gamma(\\Sigma_c^0) = 1.55 +0.41/-0.37 \\pm 0.38$ MeV/c^2 and $\\Gamma(\\Sigma_c^0) = 2.05 +0.41/-0.38 \\pm 0.38$ MeV/c^2. The first errors are statistical, the second systematic. These results are obtained with a sample of 913 $\\Sigma_c^0 \\to \\Lambda_c^+ \\pi^-$ decays and 1110 $\\Sigma_c^++ \\to \\Lambda_c^+ \\pi^+$ decays. These results are compared with recent theoretical predictions. PACS numbers: 14.20.Lq 13.30Eg

  17. Measurements of the $\\Sigma_{c}^{0}$ and $\\Sigma_{c}^{++}$ Mass Splittings

    CERN Document Server

    Link, J M; Reyes, M; Yager, P M; Anjos, J C; Bediaga, I; Göbel, C; Magnin, J; De Miranda, J M; Pepe, I M; Dos Reis, A C; Simão, F R A; Carrillo, S; Casimiro, E; Méndez, H; Sánchez-Hernández, A; Uribe, C; Vázquez, F; Cinquini, L; Cumalat, J P; Ramírez, J E; O'Reilly, B; Vaandering, E W; Butler, J N; Cheung, H W K; Gaines, I; Garbincius, P H; Garren, L A; Gottschalk, E E; Gourlay, S A; Kasper, P H; Kreymer, A E; Kutschke, R; Bianco, S; Fabbri, Franco Luigi; Sarwar, S; Zallo, A; Cawlfield, C; Kim, D Y; Park, K S; Rahimi, A; Wiss, J; Gardner, R; Chung, Y S; Kang, J S; Ko, B R; Kwak, J W; Lee, K B; Myung, S S; Park, H; Alimonti, G; Boschini, M; Brambilla, D; Caccianiga, B; Calandrino, A; D'Angelo, P; Di Corato, M; Dini, P; Giammarchi, M G; Inzani, P; Leveraro, F; Malvezzi, S; Menasce, D; Mezzadri, M; Milazzo, L; Moroni, L; Pedrini, D; Prelz, F; Rovere, M; Sala, A; Sala, S; Davenport, T F; Arena, V; Boca, G; Bonomi, G; Gianini, G; Liguori, G; Merlo, M; Pantea, D; Ratti, S P; Riccardi, C; Torre, P; Viola, L; Vitulo, P; Hernández, H; López, A M; Méndez, L; Mirles, M A; Montiel, E; Olaya, D; Quinones, J; Rivera, C; Zhang, Y; Copty, N K; Purohit, M; Wilson, J R; Cho, K; Handler, T; Engh, D; Johns, W E; Hosack, M; Nehring, M S; Sales, M; Sheldon, P D; Stenson, K; Webster, M S; Sheaff, M; Kwon, Y J

    2000-01-01

    Using a high statistics sample of photoproduced charmed particles from the FOCUS experiment at Fermilab (FNAL-E831), we measure the mass splittings of the charmed baryons Sigma_c^0 and Sigma_c^{++}. We find M(Sigma_c^0 - Lambda_c^+) = 167.38 +/- 0.21 +/- 0.13 MeV/c^2 and M(Sigma_c^++ - Lambda_c^+) = 167.35 +/- 0.19 +/- 0.12 MeV/c^2 with samples of 362 +/- 36 and 461 +/- 39 events, respectively. We measure the isospin mass splitting M(Sigma_c^++ - Sigma_c^0) to be -0.03 +/- 0.28 +/- 0.11 Mev/c^2. The first errors are statistical and the second are systematic.

  18. Operation of six sigma in production engineering

    Directory of Open Access Journals (Sweden)

    Eduardo José Pereira Martin

    2016-03-01

    Full Text Available In an increasingly competitive world, where deadlines and targets are becoming more narrow and difficult to achieve, organizations are seeking new competitive advantages that allow them to improve their development, and it is in this context that the Six Sigma program offers a way to enable such income. This study consists of a literature review on the topic: Six Sigma; and a bibliometric review in order to identify the use of the Six Sigma program in Production Engineering. The database ABEPRO was used for the research, which resulted in a set of 34 publications that identified the main centers of studies, authors and more universities that have published articles on the subject, the most recurrent keywords used, number of publications per year, the type of research presented and the tools used in conjunction with the Six Sigma program. Through analysis of the selected articles, it was possible to answer such questions as those asked above

  19. Lean six sigma application to transportation logistics

    Directory of Open Access Journals (Sweden)

    Simone Tavares Fernandes

    2012-06-01

    Full Text Available This work presents the application of Lean Six Sigma in a case study of a metallurgic industry. The Six Sigma and the Lean are two processes used by enterprises in Brazil and worldwide. Currently the integration of these processes is a challenge for these companies, which search a way more efficient to reduce their wastes and to adapt to the needs of their markets. The paper had as purpose to demonstrate the applicability of the Lean Six Sigma in a real logistical problem related to the transportation of goods among units of a metallurgic industry. The stages used for the solution of the problem follow the DMAIC cycle – Define, Measure, Analyze, Improve and Control. The paper presents in details the integrated approach of the improvement processes Lean and Six Sigma, their tools set, as well the excellent results obtained in the case study.

  20. Regulation of alternative sigma factor use.

    Science.gov (United States)

    Österberg, Sofia; del Peso-Santos, Teresa; Shingler, Victoria

    2011-01-01

    Alternative bacterial sigma factors bind the catalytic core RNA polymerase to confer promoter selectivity on the holoenzyme. The different holoenzymes are thus programmed to recognize the distinct promoter classes in the genome to allow coordinated activation of discrete sets of genes needed for adaptive responses. To form the holoenzymes, the different sigma factors must be available to compete for their common substrate (core RNA polymerase). This review highlights (a) the roles of antisigma factors in controlling the availability of alternative sigma factors and (b) the involvement of diverse regulatory molecules that promote the use of alternative sigma factors through subversion of the domineering housekeeping σ(70). The latter include the nucleotide alarmone ppGpp and small proteins (DksA, Rsd, and Crl), which directly target the transcriptional machinery to mediate their effects.

  1. Properties of sigma and kappa Production Amplitudes

    CERN Document Server

    Ishida, M; Ishida, Muneyuki; Ishida, Shin

    2003-01-01

    Our method of analysis, which led to existence of sigma and kappa mesons, is reviewed and examined from a viewpoint of general S-matrix. It is shown that the method is consistent with the constraints from chiral symmetry and unitarity. Accordingly the long-believed common analyses of pipi (Kpi) scattering and production processes, based on elastic unitarity, prove to lose its theoretical base. The observed phase motion by 180 degrees of sigma shows also the validity of our method.

  2. Generalized Kahler Geometry from supersymmetric sigma models

    CERN Document Server

    Bredthauer, A; Persson, J; Zabzine, M; Bredthauer, Andreas; Lindstrom, Ulf; Persson, Jonas; Zabzine, Maxim

    2006-01-01

    We give a physical derivation of generalized Kahler geometry. Starting from a supersymmetric nonlinear sigma model, we rederive and explain the results of Gualtieri regarding the equivalence between generalized Kahler geometry and the bi-hermitean geometry of Gates-Hull-Rocek. When cast in the language of supersymmetric sigma models, this relation maps precisely to that between the Lagrangian and the Hamiltonian formalisms. We also discuss topological twist in this context.

  3. Bacterial Sigma Factors and Anti-Sigma Factors: Structure, Function and Distribution

    Directory of Open Access Journals (Sweden)

    Mark S. Paget

    2015-06-01

    Full Text Available Sigma factors are multi-domain subunits of bacterial RNA polymerase (RNAP that play critical roles in transcription initiation, including the recognition and opening of promoters as well as the initial steps in RNA synthesis. This review focuses on the structure and function of the major sigma-70 class that includes the housekeeping sigma factor (Group 1 that directs the bulk of transcription during active growth, and structurally-related alternative sigma factors (Groups 2–4 that control a wide variety of adaptive responses such as morphological development and the management of stress. A recurring theme in sigma factor control is their sequestration by anti-sigma factors that occlude their RNAP-binding determinants. Sigma factors are then released through a wide variety of mechanisms, often involving branched signal transduction pathways that allow the integration of distinct signals. Three major strategies for sigma release are discussed: regulated proteolysis, partner-switching, and direct sensing by the anti-sigma factor.

  4. Regulation of antimicrobial resistance by extracytoplasmic function (ECF) sigma factors.

    Science.gov (United States)

    Woods, Emily C; McBride, Shonna M

    2017-01-30

    Extracytoplasmic function (ECF) sigma factors are a subfamily of σ(70) sigma factors that activate genes involved in stress-response functions. In many bacteria, ECF sigma factors regulate resistance to antimicrobial compounds. This review will summarize the ECF sigma factors that regulate antimicrobial resistance in model organisms and clinically relevant pathogens.

  5. Six sigma quality for fuel manufacturing

    Energy Technology Data Exchange (ETDEWEB)

    Gabbani, M.D.; Onderwater, T. [GE Canada, Fuel Manufacturing Plant, Peterborough, Ontario (Canada)

    1997-07-01

    It is widely recognized that operational performance in product manufacturing is largely determined by understanding and maintaining process capability. By definition, Six Sigma is a statistical unit of measure reflecting process capability that yields less' than 6.8 defects per million product produced. Statistically, this translates into obtaining a long term manufacturing process capability of {+-} 4.5 standard deviations aboutthe mean within specification limits. The heart of the Six Sigma program developed by the Six Sigma Academy is what we refer to as the Breakthrough Strategy. This rigorous analytical methodology is the driving force in obtaining world class performance of Six Sigma. The methodology applies statistical and practical tools in resolving a problem or improving a product or process. The application of Six Sigma focuses on attacking process input variables (independent) rather than the output variables. Focusing on these independent variables (temperature, power, force, etc.) and the variation in the end product they create, enables us to get to the root of the problem rather than react to the symptoms of the problem. In this manner we prevent defects from occurring rather than inspecting and monitoring the product. Why the need for such an ambitious program? It is estimated that the cost of failure (rework, scrap, warranties, etc.) can be as high as 15% of sales for companies typically operating at 3-4 sigma. In achieving Six Sigma, costs of failure are typically less than 5%. The thought of reducing business costs while achieving the recognition of being our customer's premier choice provides enormous incentive to reach such status. (author)

  6. Isobar Model for Photoproduction of K+Sigma0 and K0Sigma+ on the Proton

    CERN Document Server

    Mart, T

    2005-01-01

    Kaon photoproductions on the proton gamma p --> K+Sigma0 and gamma p --> K0Sigma+ have been simultaneously analyzed by using isobar models and new SAPHIR data. The result shows that isobar models such as KAON MAID require more resonances in order to explain the data.

  7. Sigma-drop in galaxies and the sigma-metallicity degeneracy

    CERN Document Server

    Koleva, Mina; De Rijcke, Sven

    2008-01-01

    In some galaxies, the central velocity dispersion, sigma, is depressed with respect to the surroundings. This sigma-drop phenomenon may have different physical origins, bearing information about the internal dynamics of the host galaxy. In this article, we stress the importance also of observational artifacts due to the sigma-metallicity degeneracy: when a spectrum of a population is compared with a template of miss-matched metallicity, the velocity dispersion may be wrongly estimated. A sigma-drop may appear in place of a metallicity peak. The discussion is illustrated using VLT/FORS spectra of diffuse elliptical galaxies. Some of the sigma-drop galaxies reported in the literature may be analysis artifacts.

  8. Six Lessons We Learned Applying Six Sigma

    Science.gov (United States)

    Carroll, Napoleon; Casleton, Christa H.

    2005-01-01

    As Chief Financial Officer of Kennedy Space Center (KSC), I'm not only responsible for financial planning and accounting but also for building strong partnerships with the CFO customers, who include Space Shuttle and International Space Station operations as well all who manage the KSC Spaceport. My never ending goal is to design, manage and continuously improve our core business processes so that they deliver world class products and services to the CFO's customers. I became interested in Six Sigma as Christa Casleton (KSC's first Six Sigma Black belt) applied Six Sigma tools and methods to our Plan and Account for Travel Costs Process. Her analysis was fresh, innovative and thorough but, even more impressive, was her approach to ensure ongoing, continuous process improvement. Encouraged by the results, I launched two more process improvement initiatives aimed at applying Six Sigma principles to CFO processes that not only touch most of my employees but also have direct customer impact. As many of you know, Six Sigma is a measurement scale that compares the output of a process with customer requirements. That's straight forward, but demands that you not only understand your processes but also know your products and the critical customer requirements. The objective is to isolate and eliminate the causes of process variation so that the customer sees consistently high quality.

  9. Measurements of sigma(e^+ e^- -> Upsilon(nS)pi^+pi^-) and sigma(e^+ e^- -> b bbar) in the Upsilon(10860) and Upsilon(11020) resonance regions

    CERN Document Server

    Santel, D; Chang, P; Abdesselam, A; Adachi, I; Aihara, H; Said, S Al; Arinstein, K; Asner, D M; Aushev, T; Ayad, R; Bakich, A M; Bansal, V; Bhuyan, B; Bobrov, A; Bondar, A; Bonvicini, G; Bračko, M; Browder, T E; Červenkov, D; Chekelian, V; Cheon, B G; Chilikin, K; Cho, K; Chobanova, V; Choi, S -K; Choi, Y; Cinabro, D; Dalseno, J; Danilov, M; Dingfelder, J; Doležal, Z; Drásal, Z; Drutskoy, A; Eidelman, S; Farhat, H; Fast, J E; Ferber, T; Gaur, V; Gabyshev, N; Garmash, A; Getzkow, D; Gillard, R; Goh, Y M; Haba, J; Hara, T; Hayasaka, K; Hayashii, H; He, X H; Hou, W -S; Hyun, H J; Iijima, T; Inami, K; Ishikawa, A; Itoh, R; Iwasaki, Y; Jaegle, I; Joffe, D; Julius, T; Kang, K H; Kato, E; Kawasaki, T; Kiesling, C; Kim, D Y; Kim, H J; Kim, J B; Kim, J H; Kim, M J; Kim, S H; Kim, Y J; Ko, B R; Kodyš, P; Korpar, S; Križan, P; Krokovny, P; Kuzmin, A; Lange, J S; Lee, I S; Li, Y; Gioi, L Li; Libby, J; Liventsev, D; Lukin, P; Matvienko, D; Miyabayashi, K; Miyata, H; Mizuk, R; Mohanty, G B; Moll, A; Mori, T; Mussa, R; Nakano, E; Nakao, M; Nanut, T; Natkaniec, Z; Nisar, N K; Nishida, S; Ogawa, S; Okuno, S; Olsen, S L; Oswald, C; Pakhlov, P; Pakhlova, G; Park, C W; Park, H; Pedlar, T K; Petrič, M; Piilonen, L E; Ribežl, E; Ritter, M; Rostomyan, A; Ryu, S; Sakai, Y; Sandilya, S; Santelj, L; Sanuki, T; Savinov, V; Schneider, O; Schnell, G; Schwanda, C; Schwartz, A J; Senyo, K; Sevior, M E; Shebalin, V; Shibata, T -A; Shiu, J -G; Shwartz, B; Sibidanov, A; Simon, F; Sohn, Y -S; Solovieva, E; Starič, M; Steder, M; Tamponi, U; Tatishvili, G; Teramoto, Y; Trabelsi, K; Uchida, M; Uglov, T; Unno, Y; Uno, S; Van Hulse, C; Vanhoefer, P; Varner, G; Vinokurova, A; Wagner, M N; Wang, P; Wang, X L; Watanabe, M; Watanabe, Y; Won, E; Yamaoka, J; Yang, Y -P; Yashchenko, S; Yook, Y; Yusa, Y; Zhang, Z P; Zhilich, V; Zhulanov, V; Zupanc, A

    2016-01-01

    We report new measurements of $R_{\\Upsilon\\pi\\pi}\\equiv\\sigma(e^+e^-\\to \\Upsilon(n{\\rm S})\\pi^+\\pi^-)/\\sigma^0_{\\mu\\mu}$ ($n$ = 1, 2, 3) and $R_b\\equiv\\sigma(e^+e^-\\to b\\bar b)/\\sigma^0_{\\mu\\mu}$ (where $\\sigma^0_{\\mu\\mu}$ is the muon-pair Born cross section) in the region $\\sqrt{s} = 10.63$-$11.05$ GeV, based on data collected with the Belle detector. Distributions in $R_{\\Upsilon\\pi\\pi}$ and $R_b$ are fit for the masses and widths of the $\\Upsilon(10860)$ and $\\Upsilon(11020)$ resonances. Unlike $R_b$, which includes a large non-resonant $b\\bar{b}$ component, we find that $R_{\\Upsilon\\pi\\pi}$ is dominated by the two resonances. With $R_{\\Upsilon\\pi\\pi}$ as the basis, the total rate at the $\\Upsilon(10860)$ peak for known final states containing bottomonium(-like) resonances is estimated. We find that $\\Upsilon(10860)$ is essentially saturated by such modes, raising doubts about the validity of masses measured using $R_b$. With $R_{\\Upsilon\\pi\\pi}$, we measure $M_{10860}=(10891.1\\pm3.2^{+0.6}_{-1.5})$ MeV/$c...

  10. Binding characteristics of sigma2 receptor ligands Características estruturais de ligantes do receptor sigma2

    OpenAIRE

    Glennon, Richard A.

    2005-01-01

    Sigma (sigma) receptors, once considered a type of opioid receptor, are now recognized as representing a unique receptive entity and at least two different types of sigma receptors have been identified: sigma1 and sigma2 receptors. Evidence suggests that these receptors might be targeted and exploited for the development of agents potentially useful for the treatment of several central disorders. This review primarily describes some of our efforts to understand those structural features that ...

  11. Disc instantons in linear sigma models

    Energy Technology Data Exchange (ETDEWEB)

    Govindarajan, Suresh E-mail: suresh@chaos.iitm.ernet.in; Jayaraman, T. E-mail: jayaram@imsc.ernet.in; Sarkar, Tapobrata E-mail: tapo@theory.tifr.res.in

    2002-12-16

    We construct a linear sigma model for open-strings ending on special Lagrangian cycles of a Calabi-Yau manifold. We illustrate the construction for the cases considered by Aganagic and Vafa (AV). This leads naturally to concrete models for the moduli space of open-string instantons. These instanton moduli spaces can be seen to be intimately related to certain auxiliary boundary toric varieties. By considering the relevant Gelfand-Kapranov-Zelevinsky (GKZ) differential equations of the boundary toric variety, we obtain the contributions to the world volume superpotential on the A-branes from open-string instantons. By using an ansatz due to Aganagic, Klemm and Vafa (AKV), we obtain the relevant change of variables from the linear sigma model to the non-linear sigma model variables--the open-string mirror map. Using this mirror map, we obtain results in agreement with those of AV and AKV for the counting of holomorphic disc instantons.

  12. Six Sigma Driven Enterprise Model Transformation

    Directory of Open Access Journals (Sweden)

    Raymond Vella

    2009-10-01

    Full Text Available Enterprise architecture methods provide a structured system to understand enterprise activities. However, existing enterprise modelling methodologies take static views of the enterprise and do not naturally lead to a path of improvement during enterprise model transformation. This paper discusses the need for a methodology to facilitate changes for improvement in an enterprise. The six sigma methodology is proposed as the tool to facilitate progressive and continual Enterprise Model Transformation to allow businesses to adapt to meet increased customer expectation and global competition. An alignment of six sigma with phases of GERAM life cycle is described with inclusion of Critical-To-Satisfaction (CTS requirements. The synergies of combining the two methodologies are presented in an effort to provide a more culturally embedded framework for Enterprise Model Transformation that builds on the success of six sigma.

  13. Sigma photoproduction in the resonance region

    CERN Document Server

    Janssen, S; Debruyne, D; Van Cauteren, T

    2002-01-01

    A study of p(gamma,K)Sigma processes in an isobar model at tree level is reported. By comparing model calculations to the published SAPHIR data, we explore the possible role of different isospin I=1/2 (N*) and I=3/2 (Delta*) resonances in the reaction dynamics. In our analysis, the inclusion of the ``missing'' D_{13}(1895) resonance does only slightly improve the global description of the Sigma photoproduction data. More convincing signals for the presence of such a ``missing'' resonance emerged in the analysis of the isospin related p(gamma,K+)Lambda reaction. Various implementations of the nonresonant part of the Sigma photoproduction amplitude are presented. The sensitivity of the computed observables and extracted resonance parameters to the uncertainties inherent to the treatment of the nonresonant (background) diagrams are discussed.

  14. Optimization of Coaching Using Six Sigma

    Directory of Open Access Journals (Sweden)

    Dumitru Colibaba-Evulet

    2011-01-01

    Full Text Available Problem statement: In today’s sports world, coaching and training methods are the subject of intensive competition amongst rivals. Innovative technologies, methodologies and preparation methods are employed to achieve a sustainable competitive advantage. Effective performance measurement, statistical analysis and data based decision taking have been identified as key elements towards efficient performance management. The statistical approach has been emphasized in order to fill the gaps in athlete’s preparation and improve performance. There is need to better connect the dots between the methods of statistical analysis and training and coaching methods used to improve the performance of an athlete or a team. Approach: Industry giants such as Motorola, General Electric and other improved the quality of their products through a statistically driven, six sigma methodology. Literatures in the six sigma performance measurement and improvement in industry, as well as traditional coaching in sports had been extensively reviewed. Research was carried out to establish potential application of six sigma in performance measurement and improvement in sports. Results: The six sigma approach was identified as a new method in measuring, analyzing, improving and analyzing sports performance and two examples were given. The methodology was applied on one example of data collected by authors over years of performance of a basketball team. Direction for further studies in the application of six sigma methodology in team and individual performance coaching and management were also identified. Conclusion: The results of this study determined that there is significant potential to successfully introduce the six sigma methodology of measurement, analysis and improvement in athletic performance. This new direction of analysis involved augmenting the existing traditional methods of coaching and performance management with a powerful methodology

  15. SIX SIGMA - A NEW APPROACH OF QUALITY

    Directory of Open Access Journals (Sweden)

    Maria Nicolai, Sofia Totolici

    2005-01-01

    Full Text Available The term six sigma was elaborated by Motorola Corp, in the early ‘80s, after a visit in Japan. The method’s application with this name has reduced the fabrication deficiencies with 99,7%, thus, in 1998, Motorola Corp. was one of the first companies to receive The Quality National Award in USA,“Malcolm Baldrige”. Then the method was used by other companies as well, which have declared that using the six sigma method, the 3,4 deficiencies per million of opportunities level may beachieved, attaining not perfection, but almost perfection.

  16. A Lean Six Sigma journey in radiology.

    Science.gov (United States)

    Bucci, Ronald V; Musitano, Anne

    2011-01-01

    The department of radiology at Akron Children's Hospital embarked on a Lean Six Sigma mission as part of a hospital wide initiative to show increased customer satisfaction, reduce employee dissatisfaction and frustration, and decrease costs. Three processes that were addressed were reducing the MRI scheduling back-log, reconciling discrepancies in billing radiology procedures, and implementing a daily management system. Keys to success is that managers provide opportunities to openly communicate between department sections to break down barriers. Executive leaders must be engaged in Lean Six Sigma for the company to be successful.

  17. All optical binary delta-sigma modulator

    Science.gov (United States)

    Sayeh, Mohammad R.; Siahmakoun, Azad

    2005-09-01

    This paper describes a novel A/D converter called "Binary Delta-Sigma Modulator" (BDSM) which operates only with nonnegative signal with positive feedback and binary threshold. This important modification to the conventional delta-sigma modulator makes the high-speed (>100GHz) all-optical implementation possible. It has also the capability to modify its own sampling frequency as well as its input dynamic range. This adaptive feature helps designers to optimize the system performance under highly noisy environment and also manage the power consumption of the A/D converters.

  18. $K^0$-$\\Sigma^+$ Photoproduction with SAPHIR

    CERN Document Server

    Bennhold, C

    1998-01-01

    Preliminary results of the analysis of the reaction p(gamma,K0)Sigma+ are presented. We show the first measurement of the differential cross section and much improved data for the total cross section than previous data. The data are compared with model predictions from different isobar and quark models that give a good description of p(gamma,K+)Lambda and p(gamma,K+)Sigma0 data in the same energy range. None of the models yield an adequate description of the data at all energies.

  19. Linezolid resistant Staphylococcus aureus

    Directory of Open Access Journals (Sweden)

    Pavani Gandham

    2014-08-01

    Full Text Available Linezolid is the only antibiotic available as an oral formulation for resistant staphylococcal infections. It is effective in skin and soft tissue infections, nosocomial pneumonias including VAP, infective endocarditis and MRSA meningitis. It is also effective in the eradication of both nasal and throat colonization of MRSA. Its high bioavailability and post antibiotic effect, ease of switching to oral therapy during its use and the fact that it can be used in patients of all ages, also in patients with liver disease and poor kidney function and its increased effectiveness over glycopeptides makes this drug a precious drug in the treatment of resistant staphylococcal infections. Linezolid resistance in staphylococcus is defined as a linezolid MIC of and #8805;8 mg/L. Reported Linezolid resistance in India and elsewhere is 2-20%. There is clonal dissemination of Linezolid Resistant Staphylococcus aureus (LRSA within or across health care settings which demands continuous surveillance to determine the emergent risk of resistance strains and to establish guidelines for appropriate use. Clinical laboratories should confirm any LRSA preferably by a second method, prior to using linezolid for serious infections. Effective surveillance, more judicious use of this antibiotic, avoiding linezolid usage for empiric therapy in hospital acquired staphylococcus infections, optimization of the pharmacological parameters of the antibiotics in specific clinical situation, decreasing bacterial load by timely surgical debridement or drainage of collections, use of combination therapies would prevent the emergence of resistance to linezolid in staphylococcus aureus. [Int J Res Med Sci 2014; 2(4.000: 1253-1256

  20. CNK1 promotes invasion of cancer cells through NF-kappaB-dependent signaling.

    Science.gov (United States)

    Fritz, Rafael D; Radziwill, Gerald

    2010-03-01

    Hallmarks of cancer cells are uncontrolled proliferation, evasion of apoptosis, angiogenesis, cell invasion, and metastasis, which are driven by oncogenic activation of signaling pathways. Herein, we identify the scaffold protein CNK1 as a mediator of oncogenic signaling that promotes invasion in human breast cancer and cervical cancer cells. Downregulation of CNK1 diminishes the invasiveness of cancer cells and correlates with reduced expression of matrix metalloproteinase 9 (MMP-9) and membrane-type 1 MMP (MT1-MMP). Ectopic expression of CNK1 elevates MT1-MMP promoter activity in a NF-kappaB-dependent manner. Moreover, CNK1 cooperates with the NF-kappaB pathway, but not with the extracellular signal-regulated protein kinase pathway, to promote cell invasion. Mechanistically, CNK1 regulates the alternative branch of the NF-kappaB pathway because knockdown of CNK1 interferes with processing of NF-kappaB2 p100 to p52 and its localization to the nucleus. In agreement with this, the invasion of CNK1-depleted cells is less sensitive to RelB downregulation compared with the invasion of control cells. Moreover, CNK1-dependent MT1-MMP promoter activation is blocked by RelB siRNA. Thus, CNK1 is an essential mediator of an oncogenic pathway involved in invasion of breast and cervical cancer cells and is therefore a putative target for cancer therapy.

  1. Autologous Dendritic Cells Prolong Allograft Survival Through Tmem176b-Dependent Antigen Cross-Presentation

    Science.gov (United States)

    Charnet, P.; Savina, A.; Tilly, G.; Gautreau, L.; Carretero-Iglesia, L.; Beriou, G.; Cebrian, I.; Cens, T.; Hepburn, L.; Chiffoleau, E.; Floto, R. A.; Anegon, I.; Amigorena, S.; Hill, M.; Cuturi, M. C.

    2015-01-01

    The administration of autologous (recipient-derived) tolerogenic dendritic cells (ATDCs) is under clinical evaluation. However, the molecular mechanisms by which these cells prolong graft survival in a donor-specific manner is unknown. Here, we tested mouse ATDCs for their therapeutic potential in a skin transplantation model. ATDC injection in combination with anti-CD3 treatment induced the accumulation of CD8+CD11c+ T cells and significantly prolonged allograft survival. TMEM176B is an intracellular protein expressed in ATDCs and initially identified in allograft tolerance. We show that Tmem176b−/− ATDCs completely failed to trigger both phenomena but recovered their effect when loaded with donor peptides before injection. These results strongly suggested that ATDCs require TMEM176B to cross-present antigens in a tolerogenic fashion. In agreement with this, Tmem176b−/− ATDCs specifically failed to cross-present male antigens or ovalbumin to CD8+ T cells. Finally, we observed that a Tmem176b-dependent cation current controls phagosomal pH, a critical parameter in cross-presentation. Thus, ATDCs require TMEM176B to cross-present donor antigens to induce donor-specific CD8+CD11c+ T cells with regulatory properties and prolong graft survival. PMID:24731243

  2. Magnetization of a Current-Carrying Superconducting Disk with B-Dependent Critical Current Density

    Science.gov (United States)

    Sohrabi, Mahdi; Babaei-Brojeny, Ali A.

    2010-11-01

    In the frame work of the critical state model (CSM), the magnetic response of a thin type-II superconducting disk that carries a radial transport current and is subjected to an applied magnetic field have been studied. To this end, we have studied the process of the magnetic flux-penetration. For a disk initially containing no magnetic flux but carrying a radial current, when a perpendicular magnetic field is applied, magnetic flux-penetration occurs in three stages: (1) the magnetic flux gradually penetrates from the edges of the disk until an instability occurs, (2) there is a rapid inflow of magnetic flux into the disk’s central region, which becomes resistive, and (3) magnetic flux continues to enter the disk, while persistent azimuthal currents flow in an outer annular region where the net current density is equal to J c . Also the behavior of a current-carrying disk subjected to an AC magnetic field is calculated. The magnetic flux, the current profiles and the magnetization hysteresis loops are calculated for several commonly used J c ( B) dependences. Finally, the results of the applications of the local field-dependent of the critical current density J c ( B) are compared with those obtained from the Bean model.

  3. Líquen aureus "algesiogênico" "Algesiogenic" lichen aureus

    Directory of Open Access Journals (Sweden)

    Roberto Rheingantz da Cunha Filho

    2006-03-01

    Full Text Available Descreve-se caso de líquen aureus em paciente do sexo feminino, com 23 anos de idade que apresentava há dois anos lesão dolorosa, purpúrica, acastanhada tendendo por semelhante a cor de ferrugem e de aspecto liquenóide no antebraço. O exame anatomopatológico revelou denso infiltrado linfo-histiocitário na derme superior papilar, com extravasamento de hemácias. O líquen aureus é relativamente raro, sendo ainda mais raro o sintoma de dor.A case is described of lichen aureus in a 23 year old female with a 2-year history of painful, purpuric, rust-coloured to tan, lichenous lesion on forearm. A biopsy specimen demonstrated a dense lymphohistiocytic infiltrate in the upper dermis, with extravasation of red cells. The "algesiogenic" lichen aureus is a very rare dermatosis.

  4. Staphylococcus aureus: methicillin-susceptible S. aureus to methicillin-resistant S. aureus and vancomycin-resistant S. aureus.

    Science.gov (United States)

    Rehm, Susan J; Tice, Alan

    2010-09-15

    The evolution of methicillin-resistant and vancomycin-resistant Staphylococcus aureus has demanded serious review of antimicrobial use and development of new agents and revised approaches to prevent and overcome drug resistance. Depending on local conditions and patient risk factors, empirical therapy of suspected S. aureus infection may require coverage of drug-resistant organisms with newer agents and novel antibiotic combinations. The question of treatment with inappropriate antibiotics raises grave concerns with regard to methicillin-resistant S. aureus selection, overgrowth, and increased virulence. Several strategies to reduce the nosocomial burden of resistance are suggested, including shortened hospital stays and outpatient parenteral antimicrobial therapy of the most serious infections.

  5. Multiple sigma subunits and the partitioning of bacterial transcription space.

    Science.gov (United States)

    Gruber, Tanja M; Gross, Carol A

    2003-01-01

    Promoter recognition in eubacteria is carried out by the initiation factor sigma, which binds RNA polymerase and initiates transcription. Cells have one housekeeping factor and a variable number of alternative sigma factors that possess different promoter-recognition properties. The cell can choose from its repertoire of sigmas to alter its transcriptional program in response to stress. Recent structural information illuminates the process of initiation and also shows that the two key sigma domains are structurally conserved, even among diverse family members. We use the sigma repertoire of Escherichia coli, Bacillus subtilis, Streptomyces coelicolor, and cyanobacteria to illustrate the different strategies utilized to organize transcriptional space using multiple sigma factors.

  6. Model Companions of T_\\sigma for stable T

    OpenAIRE

    Baldwin, John; Shelah, Saharon

    2001-01-01

    Let T be a complete first order theory in a countable relational language L . We assume relation symbols have been added to make each formula equivalent to a predicate. Adjoin a new unary function symbol sigma to obtain the language L_sigma; T_sigma is obtained by adding axioms asserting that sigma is an L-automorphism. We provide necessary and sufficient conditions for T_sigma to have a model companion when T is stable. Namely, we introduce a new condition: T_sigma admits obstructions, and s...

  7. Region 4 of sigma as a target for transcription regulation.

    Science.gov (United States)

    Dove, Simon L; Darst, Seth A; Hochschild, Ann

    2003-05-01

    Bacterial sigma factors play a key role in promoter recognition, making direct contact with conserved promoter elements. Most sigma factors belong to the sigma70 family, named for the primary sigma factor in Escherichia coli. Members of the sigma70 family typically share four conserved regions and, here, we focus on region 4, which is directly involved in promoter recognition and serves as a target for a variety of regulators of transcription initiation. We review recent advances in the understanding of the mechanism of action of regulators that target region 4 of sigma.

  8. PCR mutagenesis identifies a polymerase-binding sequence of sigma 54 that includes a sigma 70 homology region.

    Science.gov (United States)

    Tintut, Y; Gralla, J D

    1995-10-01

    Sigma 54 is a minor bacterial sigma factor that is not a member of the sigma 70 family of proteins but binds the same core RNA polymerase. Previously, we identified a region of sigma 54 that is important for binding core polymerase. In this work, PCR mutagenesis was used to identify specific amino acids important for this binding. The results show that important residues are clustered most closely in a short sequence that was previously speculated to be potentially homologous to a sequence in sigma 70. The mutagenesis also identifies important residues in the flanking hydrophobic-acidic region of sigma 54, which is absent in sigma 70. Overall, the data indicate that sigma 54 binds core polymerase through a sequence homologous to that of sigma 70 but in addition uses unique motifs to modify this interaction.

  9. Six Sigma in the process industries; Six Sigma in der Prozessindustrie

    Energy Technology Data Exchange (ETDEWEB)

    Bamberg, A. [Merck KgaA, Zentrale Verfahrensentwicklung, Darmstadt (Germany); Duennebier, G. [Bayer Technology Services GmbH, Leverkusen (Germany); Jaeckle, C. [Wacker Chemie AG, Burghausen (Germany); Kraemer, S. [INEOS Koeln GmbH, Koeln (Germany). Advanced Process Control, Engineering and Projects; Lamers, J. [Henkel KGaA, Duesseldorf (Germany); Piechottka, U. [Degussa AG, Hanau (Germany)

    2007-07-01

    Six Sigma is an established methodology supporting process improvements which originated from manufacturing industries with a strong focus on statistical methods. Its general applicability in other industries, in particular production processes in process industries, is, also due to the limited prevalence, not obvious. This contribution therefore discusses after an initial introduction of the Six Sigma methodology the special requirements of process industries and some useful extensions of the Six Sigma toolbox. The theoretical part is followed by the discussion of three successful improvement projects from three different companies in the German chemical industries to illustrate the applicability in industrial reality. (orig.)

  10. Tethering sigma70 to RNA polymerase reveals high in vivo activity of sigma factors and sigma70-dependent pausing at promoter-distal locations.

    Science.gov (United States)

    Mooney, Rachel Anne; Landick, Robert

    2003-11-15

    Bacterial sigma factors compete for binding to RNA polymerase (RNAP) to control promoter selection, and in some cases interact with RNAP to regulate at least the early stages of transcript elongation. However, the effective concentration of sigmas in vivo, and the extent to which sigma can regulate transcript elongation generally, are unknown. We report that tethering sigma70 to all RNAP molecules via genetic fusion of rpoD to rpoC (encoding sigma70 and RNAP's beta' subunit, respectively) yields viable Escherichia coli strains in which alternative sigma-factor function is not impaired. beta'::sigma70 RNAP transcribed DNA normally in vitro, but allowed sigma70-dependent pausing at extended -10-like sequences anywhere in a transcriptional unit. Based on measurement of the effective concentration of tethered sigma70, we conclude that the effective concentration of sigma70 in E. coli (i.e., its thermodynamic activity) is close to its bulk concentration. At this level, sigma70 would be a bona fide elongation factor able to direct transcriptional pausing even after its release from RNAP during promoter escape.

  11. Need of Six Sigma in Education

    Science.gov (United States)

    Mehrotra, Dheeraj

    2007-01-01

    The marching trend of the new economic order has generated a new capsule of SIX SIGMA as a unified approach to process excellence. The tests reveal that it has transformed some of the most successful companies in the world like Motorola, GE etc. It is activated as an approach to aiming at the target by changing the culture of a company, involving…

  12. Six Sigma and Introductory Statistics Education

    Science.gov (United States)

    Maleyeff, John; Kaminsky, Frank C.

    2002-01-01

    A conflict exists between the way statistics is practiced in contemporary business environments and the way statistics is taught in schools of management. While businesses are embracing programs, such as six sigma and TQM, that bring statistical methods to the forefront of management decision making, students do not graduate with the skills to…

  13. Improving Learning Outcome Using Six Sigma Methodology

    Science.gov (United States)

    Tetteh, Godson A.

    2015-01-01

    Purpose: The purpose of this research paper is to apply the Six Sigma methodology to identify the attributes of a lecturer that will help improve a student's prior knowledge of a discipline from an initial "x" per cent knowledge to a higher "y" per cent of knowledge. Design/methodology/approach: The data collection method…

  14. How Six Sigma Methodology Improved Doctors' Performance

    Science.gov (United States)

    Zafiropoulos, George

    2015-01-01

    Six Sigma methodology was used in a District General Hospital to assess the effect of the introduction of an educational programme to limit unnecessary admissions. The performance of the doctors involved in the programme was assessed. Ishikawa Fishbone and 5 S's were initially used and Pareto analysis of their findings was performed. The results…

  15. Lean Six Sigma for Service and Healthcare

    NARCIS (Netherlands)

    J. de Mast; R.J.M.M. Does; H. de Koning

    2006-01-01

    Lean Six Sigma is built on principles and methods that have proven themselves over the twentieth century. It has incorporated the most effective approaches and integrated them into a full programme. It offers a management structure for organizing continuous improvement of routine tasks, such as manu

  16. The Scientific Underpinning of Lean Six Sigma

    NARCIS (Netherlands)

    R.J.M.M. Does; J. de Mast; H. de Koning; S. Bisgaard

    2007-01-01

    The twentieth century saw an incredible development of professional organizations. The impact of technological advances is obvious, but besides these, innovations in management structures and methods have resulted in the highly productive organizations of today. Lean Six Sigma is not revolutionary.

  17. Lean Six Sigma: Stap voor stap

    NARCIS (Netherlands)

    Does, R.J.M.M.; de Koning, H.; de Mast, J.

    2008-01-01

    Lean Six Sigma is de culminatie van ontwikkelingen in kwaliteitsverbetering in de 20ste eeuw. Het combineert belangrijke principes en technieken in een goed gestructureerde en geïntegreerde benadering. Het belichaamt wetenschappelijke inzichten over onderzoeksmethodologie, management en economie. In

  18. Extracytoplasmic function sigma factors in Pseudomonas syringae

    DEFF Research Database (Denmark)

    Kiil, Kristoffer; Oguiza, J.A.; Ussery, D.W.

    2005-01-01

    Genome analyses of the plant pathogens Pseudomonas syringae pv. tomato DC3000, pv. syringae B728a and pv. phaseolicola 1448A reveal fewer extracytoplasmic function (ECF) sigma factors than in related Pseudomonads with different lifestyles. We highlight the presence of a P. syringae-specific ECF...

  19. Design of Low Power Sigma Delta ADC

    Directory of Open Access Journals (Sweden)

    Mohammed Arifuddin Sohel

    2012-08-01

    Full Text Available A Low power discrete time sigma delta ADC consisting of a second order sigma delta modulator and third order Cascaded Integrated Comb (CIC filter is proposed. The second order modulator is designed to work at a signal band of 20 K Hz at an oversampling ratio of 64 with a sampling frequency of 2.56 MHz. It achieves a signal to noise ratio of 85.2dB and a resolution of 14 bits. The CIC digital filter is designed to implement a decimation factor of 64, operating at a maximum sampling frequency of 2.56 MHz. A second order sigma delta modulator is implemented in 0.18 micron CMOS technology using full custom design and the third order digital CIC decimation filter is implemented in verilog HDL. The complete Sigma Delta ADC, consisting of analog block of second order modulator and digital block of decimator consumes a total power 1.96mW.

  20. Design of Low Power Sigma Delta ADC

    Directory of Open Access Journals (Sweden)

    Mohammed Arifuddin Sohel

    2012-09-01

    Full Text Available A Low power discrete time sigma delta ADC consisting of a second order sigma delta modulator and third order Cascaded Integrated Comb (CIC filter is proposed. The second order modulator is designed to work at a signal band of 20K Hz at an oversampling ratio of 64 with a sampling frequency of 2.56 MHz. It achieves a signal to noise ratio of 85.2dB and a resolution of 14 bits. The CIC digital filter is designed to implement a decimation factor of 64, operating at a maximum sampling frequency of 2.56 MHz. A second order sigma delta modulator is implemented in 0.18micron CMOS technology using full custom design and the third order digital CIC decimation filter is implemented in verilog HDL. The complete Sigma Delta ADC, consisting of analog block of second order modulator and digital block of decimator consumes a total power 1.96mW.

  1. Continuous selections and sigma-spaces

    CERN Document Server

    Repovs, Dusan; Zdomskyy, Lyubomyr

    2007-01-01

    Assume that X is a metrizable separable space, and each clopen-valued lower semicontinuous multivalued map Phi from X to Q has a continuous selection. Our main result is that in this case, X is a sigma-space. We also derive a partial converse implication, and present a reformulation of the Scheepers Conjecture in the language of continuous selections.

  2. Sigma-models and Homotopy Algebras

    CERN Document Server

    Zeitlin, Anton M

    2015-01-01

    We review the relation between homotopy algebras of conformal field theory and geometric structures arising in sigma models. In particular we formulate conformal invariance conditions, which in the quasi-classical limit are Einstein equations with extra fields, as generalized Maurer-Cartan equations.

  3. A New Measurement of the Masses and Widths of the Sigma_c^*++ and Sigma_c^*0 Charmed Baryons

    OpenAIRE

    Athar, S. B.

    2004-01-01

    Using data recorded by the CLEO III detector at CESR, we have made measurements of some properties of the Sigma_c^{*++} and Sigma_c^{*0} charmed baryons. In particular: Gamma(Sigma_c^{*++})=14.4^{+1.6}_{-1.5}+-1.4 MeV, M(Sigma_c^{*++})-M(Lambda_c^+) = 231.5+-0.4+-0.3 MeV, Gamma(Sigma_c^{*0})=16.6^{+1.9}_{-1.7}+-1.4 MeV, M(Sigma_c^{*0})-M(Lambda_c^+) = 231.4+-0.5+-0.3 MeV.

  4. Pathogenesis of Staphylococcus aureus abscesses.

    Science.gov (United States)

    Kobayashi, Scott D; Malachowa, Natalia; DeLeo, Frank R

    2015-06-01

    Staphylococcus aureus causes many types of human infections and syndromes-most notably skin and soft tissue infections. Abscesses are a frequent manifestation of S. aureus skin and soft tissue infections and are formed, in part, to contain the nidus of infection. Polymorphonuclear leukocytes (neutrophils) are the primary cellular host defense against S. aureus infections and a major component of S. aureus abscesses. These host cells contain and produce many antimicrobial agents that are effective at killing bacteria, but can also cause non-specific damage to host tissues and contribute to the formation of abscesses. By comparison, S. aureus produces several molecules that also contribute to the formation of abscesses. Such molecules include those that recruit neutrophils, cause host cell lysis, and are involved in the formation of the fibrin capsule surrounding the abscess. Herein, we review our current knowledge of the mechanisms and processes underlying the formation of S. aureus abscesses, including the involvement of polymorphonuclear leukocytes, and provide a brief overview of therapeutic approaches.

  5. SIX SIGMA: A METRIC, A METHODOLOGY AND A MANAGEMENT SYSTEM

    Directory of Open Access Journals (Sweden)

    Mureşan Ioana

    2010-07-01

    Full Text Available This article is a theoretical article regarding Six Sigma. Six Sigma has been interpreted over time within quality theory as a metric, methodology or a management system. We explain Six Sigma using a logistics context: Delivery-On-Time (DOT rate problem. It is a theoretical context useful both for academic users and practitioners. At the beginning of the paper the DOT problem is generally described, while Sigma is presented according to statisticians view in the second part of the paper. Six Sigma is then presented as a metric for process’ capability. The fourth part of this article contains details regarding Six Sigma usage as a methodology for improvement, while the fifth part of this article refers to Six Sigma as a management system which can be used at firms’ level. The last chapter is dedicated to conclusions regarding the possible use of Six Sigma in Romania.

  6. Strong $\\Sigma_bNB$ and $\\Sigma_cND$ vertices in QCD

    CERN Document Server

    Azizi, K; Sundu, H

    2015-01-01

    We study the strong interactions among the heavy bottom spin--1/2 $\\Sigma_b$ baryon, nucleon and $B$ meson as well as the heavy charmed spin--1/2 $\\Sigma_c$ baryon, nucleon and $D$ meson in the context of QCD sum rules. We calculate the corresponding strong coupling form factors defining these vertices using a three point correlation function. We obtain the numerical values of the corresponding strong coupling constants via different Dirac structures entering the calculations.

  7. Investigating the green impact of lean, six sigma, and lean six sigma: A systematic literature review

    OpenAIRE

    Chugani, N.; Kumar, V.; Garza-Reyes, J. A.; Rocha-Lona, L.; Upadhyay, A.

    2016-01-01

    Purpose - The academic literature and research lines exploring the effect of quality improvement methods on environmental performance still remain in early stages. The purpose of this study is therefore to investigate, through a systematic review of the existing academic literature, the environmental (green) impact of using quality and operations improvement methods such as Lean, Six Sigma, and Lean Six Sigma. This includes the impact on energy saving and the usage of natural resources.\\ud \\u...

  8. $\\bar{D}\\Sigma^*_c$ and $\\bar{D}^*\\Sigma_c$ interactions and LHCb pentaquarks

    CERN Document Server

    He, Jun

    2016-01-01

    Recently, LHCb collaboration reported the observation of two hidden-charmed resonances $P_c(4380)$ and $P_c(4450)$ consistent with hidden-charmed pentaquarks. We perform a dynamical investigation about the $\\bar{D}\\Sigma_c^*(2520)$ and $\\bar{D}^*\\Sigma_c(2455)$ interactions which are described by the meson exchanges in a quasipotential Bethe-Salpeter equation approach. Two poles around $4450$ and $4390$ MeV are produced from the $\\bar{D}^*\\Sigma_c(2455)$ interaction with spin parities $3/2^-$ and $5/2^+$, respectively. The peak for $5/2^+$ state has a comparable hight as that of $3/2^-$ state in the $J/\\psi p$ invariant mass spectrum. Another bound state with spin-parity $J^P=3/2^-$ is produced from the $\\bar{D}\\Sigma^*_c(2520)$ interaction. Such results suggest that the narrower LHCb pentaquark $P_c(4450)$ can be well interpreted as a $5/2^+$ $\\bar{D}^*\\Sigma_c(2455)$ molecular state while the $P_c(4380)$ is a $3/2^-$ $\\bar{D}^*\\Sigma_c(2455)$ molecular state mixed with other secondary origins.

  9. Alternative Sigma Factors and Their Roles in Bacterial Virulence

    OpenAIRE

    Kazmierczak, Mark J.; Wiedmann, Martin; Boor, Kathryn J.

    2005-01-01

    Sigma factors provide promoter recognition specificity to RNA polymerase holoenzyme, contribute to DNA strand separation, and then dissociate from the core enzyme following transcription initiation. As the regulon of a single sigma factor can be composed of hundreds of genes, sigma factors can provide effective mechanisms for simultaneously regulating expression of large numbers of prokaryotic genes. One newly emerging field is identification of the specific roles of alternative sigma factors...

  10. Staphylococcus aureus Bacteraemia

    Directory of Open Access Journals (Sweden)

    James Price

    2010-01-01

    Full Text Available Staphylococcus aureus bacteraemia (SAB is commonly complicated by metastatic infection or relapse after treatment. Objectives. The study aim was to determine the role of bacterial, host, and management factors in development of complicated SAB. Methods. A prospectively-conducted observational study gathered data on predisposition, management and outcome of 100 consecutive SAB cases. Antibiotic susceptibilities and genetic lineage of bacterial isolates were determined. Further clinical and microbiological data were gathered on two retrospective series from 1999–2000 (n=57 and 2004 (n=116. Results. In the prospective cases, 27% met our definition of complicated disease. Expressed as RR and 95% CI, complicated disease was associated with diabetes (1.58, 1.00–2.48, injecting-drug use (5.48, 0.88–33.49, community-onset of symptoms (1.4, 1.02–1.92, and symptom duration ≥48 hours prior to starting effective antibiotic therapy (2.10, 1.22–3.61. Uncomplicated disease was associated with the presence of a central line (0.69, 0.55–0.88 and prompt removal of a primary focus (0.71, 0.57–0.90. Neither methicillin resistance nor genetic lineage was associated with complicated disease, but methicillin resistance was associated with higher mortality. Conclusions. This study demonstrates that clinical rather than microbial factors are the major determinants of SAB outcome and underscores the importance of early treatment.

  11. Operational excellence (six sigma) philosophy: Application to software quality assurance

    Energy Technology Data Exchange (ETDEWEB)

    Lackner, M.

    1997-11-01

    This report contains viewgraphs on operational excellence philosophy of six sigma applied to software quality assurance. This report outlines the following: goal of six sigma; six sigma tools; manufacturing vs administrative processes; Software quality assurance document inspections; map software quality assurance requirements document; failure mode effects analysis for requirements document; measuring the right response variables; and questions.

  12. Incorporating Six Sigma Methodology Training into Chemical Engineering Education

    Science.gov (United States)

    Dai, Lenore L.

    2007-01-01

    Six Sigma is a buzz term in today's technology and business world and there has been increasing interest to initiate Six Sigma training in college education. We have successfully incorporated Six Sigma methodology training into a traditional chemical engineering course, Engineering Experimentation, at Texas Tech University. The students have…

  13. The cholinergic system, sigma-1 receptors and cognition

    NARCIS (Netherlands)

    van Waarde, Aren; Ramakrishnan, Nisha K.; Rybczynska, Anna A.; Elsinga, Philip H.; Ishiwata, Kiichi; Nijholt, Ingrid M.; Luiten, Paul G. M.; Dierckx, Rudi A.

    2011-01-01

    This article provides an overview of present knowledge regarding the relationship between the cholinergic system and sigma-1 receptors, and discusses potential applications of sigma-1 receptor agonists in the treatment of memory deficits and cognitive disorders. Sigma-1 receptors, initially consider

  14. Staphylococcus aureus Transcriptome Architecture: From Laboratory to Infection-Mimicking Conditions.

    Directory of Open Access Journals (Sweden)

    Ulrike Mäder

    2016-04-01

    Full Text Available Staphylococcus aureus is a major pathogen that colonizes about 20% of the human population. Intriguingly, this Gram-positive bacterium can survive and thrive under a wide range of different conditions, both inside and outside the human body. Here, we investigated the transcriptional adaptation of S. aureus HG001, a derivative of strain NCTC 8325, across experimental conditions ranging from optimal growth in vitro to intracellular growth in host cells. These data establish an extensive repertoire of transcription units and non-coding RNAs, a classification of 1412 promoters according to their dependence on the RNA polymerase sigma factors SigA or SigB, and allow identification of new potential targets for several known transcription factors. In particular, this study revealed a relatively low abundance of antisense RNAs in S. aureus, where they overlap only 6% of the coding genes, and only 19 antisense RNAs not co-transcribed with other genes were found. Promoter analysis and comparison with Bacillus subtilis links the small number of antisense RNAs to a less profound impact of alternative sigma factors in S. aureus. Furthermore, we revealed that Rho-dependent transcription termination suppresses pervasive antisense transcription, presumably originating from abundant spurious transcription initiation in this A+T-rich genome, which would otherwise affect expression of the overlapped genes. In summary, our study provides genome-wide information on transcriptional regulation and non-coding RNAs in S. aureus as well as new insights into the biological function of Rho and the implications of spurious transcription in bacteria.

  15. Nicotine stimulates nerve growth factor in lung fibroblasts through an NFκB-dependent mechanism.

    Directory of Open Access Journals (Sweden)

    Cherry Wongtrakool

    Full Text Available Airway hyperresponsiveness (AHR is classically found in asthma, and persistent AHR is associated with poor asthma control. Although airway smooth muscle (ASM cells play a critical pathophysiologic role in AHR, the paracrine contributions of surrounding cells such as fibroblasts to the contractile phenotype of ASM cells have not been examined fully. This study addresses the hypothesis that nicotine promotes a contractile ASM cell phenotype by stimulating fibroblasts to increase nerve growth factor (NGF secretion into the environment.Primary lung fibroblasts isolated from wild type and α7 nicotinic acetylcholine receptor (α7 nAChR deficient mice were treated with nicotine (50 µg/ml in vitro for 72 hours. NGF levels were measured in culture media and in bronchoalveolar lavage (BAL fluid from asthmatic, smoking and non-smoking subjects by ELISA. The role of the NFκB pathway in nicotine-induced NGF expression was investigated by measuring NFκB nuclear translocation, transcriptional activity, chromatin immunoprecipitation assays, and si-p65 NFκB knockdown. The ability of nicotine to stimulate a fibroblast-mediated, contractile ASM cell phenotype was confirmed by examining expression of contractile proteins in ASM cells cultured with fibroblast-conditioned media or BAL fluid.NGF levels were elevated in the bronchoalveolar lavage fluid of nicotine-exposed mice, current smokers, and asthmatic children. Nicotine increased NGF secretion in lung fibroblasts in vitro in a dose-dependent manner and stimulated NFκB nuclear translocation, p65 binding to the NGF promoter, and NFκB transcriptional activity. These responses were attenuated in α7 nAChR deficient fibroblasts and in wild type fibroblasts following NFκB inhibition. Nicotine-treated, fibroblast-conditioned media increased expression of contractile proteins in ASM cells.Nicotine stimulates NGF release by lung fibroblasts through α7 nAChR and NFκB dependent pathways. These novel findings

  16. $sigma(600)$ and background in $pipi$ scattering

    CERN Document Server

    Kaloshin, A E; Vall, A N

    2003-01-01

    We suggest a simple analytical description of the S-wave isoscalar $pipi$ amplitude, which corresponds to a joint dressing of the bare resonance and background contributions. The amplitude describes well the experimental data on the $delta^0_0$ phase shift in the energy region below 900 MeV and has two poles in the $Re s > 0$ half-plane. Besides the well-known pole of $sigma(600)$-meson with $Re s sim m_{pi}^2$, there exists a more distant pole with $Re s sim 0.6 GeV^2$. Our analysis indicates for the dynamical origin of the $sigma(600)$ pole, while the second pole should be associated with lowest $qbar{q}$ state.

  17. Sigma-Model Solitons on Noncommutative Spaces

    Science.gov (United States)

    Dabrowski, Ludwik; Landi, Giovanni; Luef, Franz

    2015-12-01

    We use results from time-frequency analysis and Gabor analysis to construct new classes of sigma-model solitons over the Moyal plane and over noncommutative tori, taken as source spaces, with a target space made of two points. A natural action functional leads to self-duality equations for projections in the source algebra. Solutions, having nontrivial topological content, are constructed via suitable Morita duality bimodules.

  18. Performance evaluation of photonic Sigma Delta ADCS

    OpenAIRE

    Tan, Yean Wee

    2010-01-01

    Approved for public release; distribution is unlimited The integration of photonic and electronic components to realize a photonic sigma delta ADC is considered in this thesis. The integration process was broken up into steps. First, the performance of a pair of dual-port Mach-Zehnder interferometers (MZI) modulating a train of narrow high-speed laser pulses from a mode-locked laser was investigated. Various parameters like the half-wave voltage (V) and insertion loss were verified. Nex...

  19. Value Engineering Synergies with Lean Six Sigma

    Science.gov (United States)

    2010-09-01

    70 Ibid. 71 Cook, Michael J., “How to Get Six Sigma Companies to Use VM and Function Analysis ,” in SAVE International 43rd Annual Conference...Voice of Customer Strengths, Weaknesses, Opportunities, and Threats ( SWOT ) Project Charter Benchmarking Design for Assembly Pareto Analysis Tear...initiative has different phases in its methodological approach: • VE phases are orientation, information, function analysis , creative, evaluation

  20. Non-Linear Sigma Model on Conifolds

    CERN Document Server

    Parthasarathy, R

    2002-01-01

    Explicit solutions to the conifold equations with complex dimension $n=3,4$ in terms of {\\it{complex coordinates (fields)}} are employed to construct the Ricci-flat K\\"{a}hler metrics on these manifolds. The K\\"{a}hler 2-forms are found to be closed. The complex realization of these conifold metrics are used in the construction of 2-dimensional non-linear sigma model with the conifolds as target spaces. The action for the sigma model is shown to be bounded from below. By a suitable choice of the 'integration constants', arising in the solution of Ricci flatness requirement, the metric and the equations of motion are found to be {\\it{non-singular}}. As the target space is Ricci flat, the perturbative 1-loop counter terms being absent, the model becomes topological. The inherent U(1) fibre over the base of the conifolds is shown to correspond to a gauge connection in the sigma model. The same procedure is employed to construct the metric for the resolved conifold, in terms of complex coordinates and the action ...

  1. An extra-cytoplasmic function sigma factor and anti-sigma factor control carotenoid biosynthesis in Azospirillum brasilense.

    Science.gov (United States)

    Thirunavukkarasu, Nagarajan; Mishra, Mukti Nath; Spaepen, Stijn; Vanderleyden, Jos; Gross, Carol A; Tripathi, Anil K

    2008-07-01

    Strains Sp7 and Cd of Azospirillum brasilense, a plant growth-promoting rhizobacterium, differ in synthesis of carotenoids. While colonies of strain Sp7 have a white-cream colour on plates, colonies of strain Cd are orange-pink coloured because of the synthesis of carotenoids. Screening of a mini-Tn5 mutant library of A. brasilense Sp7 revealed two orange-pink-coloured mutants that produced carotenoids. Cloning and sequencing of the Tn5 flanking region in both the carotenoid-producing mutants of Sp7 revealed insertion of Tn5 in an ORF encoding anti-sigma factor, a ChrR-like protein. The upstream region of the Tn5-mutated ORF contained another ORF that encoded an extra-cytoplasmic function (ECF)-class sigma factor (sigma(E), RpoE). When the nucleotide sequences of the corresponding ORFs from the carotenoid-producing strain Cd were analysed, the sequence of the Cd sigma(E) was identical to that of the carotenoid non-producing strain Sp7, but the Cd anti-sigma(E) ORF had a deletion that caused frame shifting and creation of a stop codon. This resulted in the premature termination of the protein, which was about 7 kDa smaller than the Sp7 anti-sigma(E). Cloning of Sp7 anti-sigma(E) in a broad-host-range expression vector and expression in A. brasilense Cd and in the anti-sigma(E) knockout mutant of A. brasilense Sp7 resulted in the inhibition of carotenoid synthesis. Similarly, cloning and overexpression of A. brasilense Sp7 sigma(E) in A. brasilense Sp7 resulted in the production of carotenoids. These observations clearly indicate that carotenoid synthesis in A. brasilense is controlled by sigma(E) with its cognate anti-sigma(E).

  2. Six sigma and lean production adoption in a manufacturing company

    Directory of Open Access Journals (Sweden)

    Alisson Christian Scheller

    2014-11-01

    Full Text Available The connection among Lean Production with Six Sigma originated the Lean Six Sigma methodology, focused on processes variation and waste reduction. This methodology was developed on different ways in the companies and there is no consensus over its structure and its implementation. In this context, this paper aims to identify and analyze the main characteristics on the adoption and integration of Lean Six Sigma methodology through a case study conducted in a manufacturing company that adopts lean production and six sigma. The results show two important aspects of the Lean Six Sigma methodology. One of them is the adoption of the value stream mapping as a central tool on Lean Six Sigma. The other is the use of DMAIC for improvements actions. The study indicates that despite the difficulties on Lean Six Sigma implementation, the methodology offers benefits to the company that adopts it in the suitable way.

  3. Plastid sigma factors: Their individual functions and regulation in transcription.

    Science.gov (United States)

    Chi, Wei; He, Baoye; Mao, Juan; Jiang, Jingjing; Zhang, Lixin

    2015-09-01

    Sigma factors are the predominant factors involved in transcription regulation in bacteria. These factors can recruit the core RNA polymerase to promoters with specific DNA sequences and initiate gene transcription. The plastids of higher plants originating from an ancestral cyanobacterial endosymbiont also contain sigma factors that are encoded by a small family of nuclear genes. Although all plastid sigma factors contain sequences conserved in bacterial sigma factors, a considerable number of distinct traits have been acquired during evolution. The present review summarises recent advances concerning the regulation of the structure, function and activity of plastid sigma factors since their discovery nearly 40 years ago. We highlight the specialised roles and overlapping redundant functions of plastid sigma factors according to their promoter selectivity. We also focus on the mechanisms that modulate the activity of sigma factors to optimise plastid function in response to developmental cues and environmental signals. This article is part of a Special Issue entitled: Chloroplast Biogenesis.

  4. K^0 pi^0 Sigma^+ and K^*0 Sigma^+ photoproduction off the proton

    CERN Document Server

    Nanova, M; Bantes, B; Bartholomy, O; Bayadilov, D; Beck, R; Beloglasov, Yu A; Castelijns, R; Credé, V; Dutz, H; Ehmanns, A; Elsner, D; Essig, K; Ewald, R; Fabry, I; Fornet-Ponse, K; Fuchs, M; Funke, C; Gothe, R; Gregor, R; Gridnev, A B; Gutz, E; Hoffmeister, P; Horn, I; Jaegle, I; Junkersfeld, J; Kalinowsky, H; Kammer, S; Kleber, V; Klein, Frank; Klein, Friedrich; Klempt, E; Konrad, M; Kotulla, M; Krusche, B; Lang, M; Langheinrich, J; Löhner, H; Lopatin, I V; Lotz, J; Lugert, S; Menze, D; Messchendorp, J G; Mertens, T; Metag, V; Morales, C; Novinski, D V; Novotny, R; Ostrick, M; Pant, L M; Van Pee, H; Pfeiffer, M; Radkov, A; Roy, A; Schadmand, S; Schmidt, C; Schmieden, H; Schoch, B; Shende, S V; Sokhoyan, V; Sule, A; Sumachev, V V; Szczepanek, T; Thoma, U; Trnka, D; Varma, R; Walther, D; Weinheimer, C; Wendel, C

    2008-01-01

    The exclusive reactions $\\gamma p \\to K^{*0} \\Sigma^+(1189)$ and $\\gamma p \\to K^{0} \\pi^{0}\\Sigma^+(1189)$, leading to the p 4$\\pi^{0}$ final state, have been measured with a tagged photon beam for incident energies from threshold up to 2.5 GeV. The experiment has been performed at the tagged photon facility of the ELSA accelerator (Bonn). The Crystal Barrel and TAPS detectors were combined to a photon detector system of almost 4$\\pi$ geometrical acceptance. Differential and total cross sections are reported. At energies close to the threshold, a flat angular distribution has been observed for the reaction $\\gamma p\\to K^{0} \\pi^{0}\\Sigma^+$ suggesting dominant s-channel production. $\\Sigma^*(1385)$ and higher lying hyperon states have been observed. An enhancement in the forward direction in the angular distributions of the reaction $\\gamma p \\to K^{*0}\\Sigma^+$ indicates a $t$-channel exchange contribution to the reaction mechanism. The experimental data are in reasonable agreement with recent theoretical ...

  5. First Observation of Heavy Baryons \\Sigma_b and \\Sigma_b^*

    CERN Document Server

    Aaltonen, T; Adelman, J; Affolder, T; Akimoto, T; Albrow, M G; Amerio, S; Amidei, D; Anastassov, A; Anikeev, K; Annovi, A; Antos, J; Aoki, M; Apollinari, G; Arisawa, T; Artikov, A; Ashmanskas, W; Attal, A; Aurisano, A; Azfar, F; Azzi-Bacchetta, P; Azzurri, P; Bacchetta, N; Badgett, W; Barbaro-Galtieri, A; Barnes, V E; Barnett, B A; Baroiant, S; Bartsch, V; Bauer, G; Beauchemin, P H; Bedeschi, F; Behari, S; Bellettini, G; Bellinger, J; Belloni, A; Benjamin, D; Beretvas, A; Beringer, J; Berry, T; Bhatti, A; Binkley, M; Bisello, D; Bizjak, I; Blair, R E; Blocker, C; Blumenfeld, B; Bocci, A; Bodek, A; Boisvert, V; Bölla, G; Bolshov, A; Bortoletto, D; Boudreau, J; Boveia, A; Brau, B; Brigliadori, L; Bromberg, C; Brubaker, E; Budagov, Yu A; Budd, H S; Budd, S; Burkett, K; Busetto, G; Bussey, P; Buzatu, A; Byrum, K L; Cabrera, S; Campanelli, M; Campbell, M; Canelli, F; Canepa, A; Carillo, S; Carlsmith, D; Carosi, R; Carron, S; Casal, B; Casarsa, M; Castro, A; Catastini, P; Cauz, D; Cavalli-Sforza, M; Cerri, A; Cerrito, L; Chang, S H; Chen, Y C; Chertok, M; Chiarelli, G; Chlachidze, G; Chlebana, F; Cho, I; Cho, K; Chokheli, D; Chou, J P; Choudalakis, G; Chuang, S H; Chung, K; Chung, W H; Chung, Y S; Cilijak, M; Ciobanu, C I; Ciocci, M A; Clark, A; Clark, D; Coca, M; Compostella, G; Convery, M E; Conway, J; Cooper, B; Copic, K; Cordelli, M; Cortiana, G; Crescioli, F; Cuenca-Almenar, C; Cuevas-Maestro, J; Culbertson, R; Cully, J C; Da Ronco, S; Datta, M; D'Auria, S; Davies, T; Dagenhart, D; De Barbaro, P; De Cecco, S; Deisher, A; De Lentdecker, G; De Lorenzo, G; Dell'Orso, Mauro; Delli Paoli, F; Demortier, L; Deng, J; Deninno, M; De Pedis, D; Derwent, P F; Di Giovanni, G P; Dionisi, C; Di Ruzza, B; Dittmann, J R; D'Onofrio, M; Dorr, C; Donati, S; Dong, P; Donini, J; Dorigo, T; Dube, S; Efron, J; Erbacher, R; Errede, D; Errede, S; Eusebi, R; Fang, H C; Farrington, S; Fedorko, I; Fedorko, W T; Feild, R G; Feindt, M; Fernández, J P; Field, R; Flanagan, G; Forrest, R; Forrester, S; Franklin, M; Freeman, J C; Furic, I; Gallinaro, M; Galyardt, J; García, J E; Garberson, F; Garfinkel, A F; Gay, C; Gerberich, H; Gerdes, D; Giagu, S; Giannetti, P; Gibson, K; Gimmell, J L; Ginsburg, C; Giokaris, N; Giordani, M; Giromini, P; Giunta, M; Giurgiu, G; Glagolev, V; Glenzinski, D; Gold, M; Goldschmidt, N; Goldstein, J; Golossanov, A; Gómez, G; Gómez-Ceballos, G; Goncharov, M; González, O; Gorelov, I; Goshaw, A T; Goulianos, K; Gresele, A; Grinstein, S; Grosso-Pilcher, C; Group, R C; Grundler, U; Guimarães da Costa, J; Gunay-Unalan, Z; Haber, C; Hahn, K; Hahn, S R; Halkiadakis, E; Hamilton, A; Han, B Y; Han, J Y; Handler, R; Happacher, F; Hara, K; Hare, D; Hare, M; Harper, S; Harr, R F; Harris, R M; Hartz, M; Hatakeyama, K; Hauser, J; Hays, C; Heck, M; Heijboer, A; Heinemann, B; Heinrich, J; Henderson, C; Herndon, M; Heuser, J; Hidas, D; Hill, C S; Hirschbuehl, D; Höcker, A; Holloway, A; Hou, S; Houlden, M; Hsu, S C; Huffman, B T; Hughes, R E; Husemann, U; Huston, J; Incandela, J; Introzzi, G; Iori, M; Ivanov, A; Iyutin, B; James, E; Jang, D; Jayatilaka, B; Jeans, D; Jeon, E J; Jindariani, S; Johnson, W; Jones, M; Joo, K K; Jun, S Y; Jung, J E; Junk, T R; Kamon, T; Karchin, P E; Kato, Y; Kemp, Y; Kephart, R; Kerzel, U; Khotilovich, V; Kilminster, B; Kim, D H; Kim, H S; Kim, J E; Kim, M J; Kim, S B; Kim, S H; Kim, Y K; Kimura, N; Kirsch, L; Klimenko, S; Klute, M; Knuteson, B; Ko, B R; Kondo, K; Kong, D J; Konigsberg, J; Korytov, A; Kotwal, A V; Kraan, A C; Kraus, J; Kreps, M; Kroll, J; Krumnack, N; Kruse, M; Krutelyov, V; Kubo, T; Kuhlmann, S E; Kuhr, T; Kulkarni, N P; Kusakabe, Y; Kwang, S; Laasanen, A T; Lai, S; Lami, S; Lammel, S; Lancaster, M; Lander, R L; Lannon, K; Lath, A; Latino, G; Lazzizzera, I; LeCompte, T; Lee, J; Lee, J; Lee, Y J; Lee, S W; Lefèvre, R; Leonardo, N; Leone, S; Levy, S; Lewis, J D; Lin, C; Lin, C S; Lindgren, M; Lipeles, E; Lister, A; Litvintsev, D O; Liu, T; Lockyer, N S; Loginov, A; Loreti, M; Lu, R S; Lucchesi, D; Lujan, P; Lukens, P; Lungu, G; Lyons, L; Lys, J; Lysak, R; Lytken, E; Mack, P; MacQueen, D; Madrak, R; Maeshima, K; Makhoul, K; Mäki, T; Maksimovic, P; Malde, S; Malik, S; Manca, G; Manousakis, A; Margaroli, F; Marginean, R; Marino, C; Marino, C P; Martin, A; Martin, M; Martin, V; Martínez, M; Martinez-Ballarin, R; Maruyama, T; Mastrandrea, P; Masubuchi, T; Matsunaga, H; Mattson, M E; Mazini, R; Mazzanti, P; McFarland, K S; McIntyre, P; McNulty, R; Mehta, A; Mehtälä, P; Menzemer, S; Menzione, A; Merkel, P; Mesropian, C; Messina, A; Miao, T; Miladinovic, N; Miles, J; Miller, R; Mills, C; Milnik, M; Mitra, A; Mitselmakher, G; Miyamoto, A; Moed, S; Moggi, N; Mohr, B; Moon, C S; Moore, R; Morello, M; Movilla-Fernández, P A; Mülmenstädt, J; Mukherjee, A; Müller, T; Mumford, R; Murat, P; Mussini, M; Nachtman, J; Nagano, A; Naganoma, J; Nakamura, K; Nakano, I; Napier, A; Necula, V; Neu, C; Neubauer, M S; Nielsen, J; Nodulman, L; Norniella, O; Nurse, E; Oh, S H; Oh, Y D; Oksuzian, I; Okusawa, T; Oldeman, R; Orava, R; Österberg, K; Pagliarone, C; Palencia, E; Papadimitriou, V; Papaikonomou, A; Paramonov, A A; Parks, B; Pashapour, S; Patrick, J; Pauletta, G; Paulini, M; Paus, C; Pellett, D E; Penzo, Aldo L; Phillips, T J; Piacentino, G; Piedra, J; Pinera, L; Pitts, K; Plager, C; Pondrom, L; Portell, X; Poukhov, O; Pounder, N; Prakoshyn, F; Pronko, A; Proudfoot, J; Ptohos, F; Punzi, G; Pursley, J; Rademacker, J; Rahaman, A; Ramakrishnan, V; Ranjan, N; Redondo, I; Reisert, B; Rekovic, V; Renton, P B; Rescigno, M; Richter, S; Rimondi, F; Ristori, L; Robson, A; Rodrigo, T; Rogers, E; Rolli, S; Roser, R; Rossi, M; Rossin, R; Roy, P; Ruiz, A; Russ, J; Rusu, V; Saarikko, H; Safonov, A; Sakumoto, W K; Salamanna, G; Salto, O; Santi, L; Sarkar, S; Sartori, L; Sato, K; Savard, P; Savoy-Navarro, A; Scheidle, T; Schlabach, P; Schmidt, E E; Schmidt, M A; Schmidt, M P; Schmitt, M; Schwarz, T; Scodellaro, L; Scott, A L; Scribano, A; Scuri, F; Sedov, A; Seidel, S; Seiya, Y; Semenov, A; Sexton-Kennedy, L; Sfyrla, A; Shalhout, S Z; Shapiro, M D; Shears, T G; Shepard, P F; Sherman, D; Shimojima, M; Shochet, M; Shon, Y; Shreyber, I; Sidoti, A; Sinervo, P; Sisakian, A; Slaughter, A J; Slaunwhite, J; Sliwa, K; Smith, J R; Snider, F D; Snihur, R; Söderberg, M; Soha, A; Somalwar, S; Sorin, V; Spalding, J; Spinella, F; Spreitzer, T; Squillacioti, P; Stanitzki, M; Staveris-Polykalas, A; Saint-Denis, R; Stelzer, B; Stelzer-Chilton, O; Stentz, D; Strologas, J; Stuart, D; Suh, J S; Sukhanov, A; Sun, H; Suslov, I; Suzuki, T; Taffard, A; Takashima, R; Takeuchi, Y; Tanaka, R; Tecchio, M; Teng, P K; Terashi, K; Tesarek, R J; Thom, J; Thompson, A S; Thomson, E; Tipton, P; Tiwari, V; Tkaczyk, S; Toback, D; Tokar, S; Tollefson, K; Tomura, T; Tonelli, D; Torre, S; Torretta, D; Tourneur, S; Trischuk, W; Tsuno, S; Tu, Y; Turini, N; Ukegawa, F; Uozumi, S; Vallecorsa, S; Van Remortel, N; Varganov, A; Vataga, E; Vázquez, F; Velev, G; Vellidis, C; Veramendi, G; Veszpremi, V; Vidal, M; Vidal, R; Vila, I; Vilar, R; Vine, T; Vogel, M; Vollrath, I; Volobuev, I P; Volpi, G; Würthwein, F; Wagner, P; Wagner, R G; Wagner, R L; Wagner, J; Wagner, W; Wallny, R; Wang, S M; Warburton, A; Waters, D; Weinberger, M; Wester, W C; Whitehouse, B; Whiteson, D; Wicklund, A B; Wicklund, E; Williams, G; Williams, H H; Wilson, P; Winer, B L; Wittich, P; Wolbers, S; Wolfe, C; Wright, T; Wu, X; Wynne, S M; Yagil, A; Yamamoto, K; Yamaoka, J; Yamashita, T; Yang, C; Yang, U K; Yang, Y C; Yao, W M; Yeh, G P; Yoh, J; Yorita, K; Yoshida, T; Yu, G B; Yu, I; Yu, S S; Yun, J C; Zanello, L; Zanetti, A; Zaw, I; Zhang, X; Zhou, J; Zucchelli, S

    2007-01-01

    We report an observation of new bottom baryons produced in proton-antiproton collisions at the Tevatron. Using 1.1 fb^{-1} of data collected by the CDF II detector, we observe four \\Lambda_b^0\\pi^{\\pm} resonances in the fully reconstructed decay mode \\Lambda_b^0 \\to \\Lambda_c^+ \\pi^-, where \\Lambda_c^+ \\to p K^- \\pi^+. We interpret these states as the \\Sigma_b^{(*)\\pm} baryons and measure their masses to be: m_{\\Sigma_b^+} = 5807.8^{+2.0}_{-2.2} (stat.) \\pm 1.7 (syst.) MeV/c^2 m_{\\Sigma_b^-} = 5815.2 \\pm 1.0 (stat.) \\pm 1.7 (syst.) MeV/c^2 m_{\\Sigma_b^{*+}} = 5829.0^{+1.6}_{-1.8} (stat.) ^{+1.7}_{-1.8} (syst.) MeV/c^2 m_{\\Sigma_b^{*-}} = 5836.4 \\pm 2.0 (stat.) ^{+1.8}_{-1.7} (syst.) MeV/c^2

  6. Mild Staphylococcus aureus skin infection improves the course of subsequent endogenous S. aureus bacteremia in mice

    NARCIS (Netherlands)

    S. van den Berg (Sanne); C.P. de Vogel (Corné); A.F. van Belkum (Alex); I.A.J.M. Bakker-Woudenberg (Irma)

    2015-01-01

    textabstractStaphylococcus aureus carriers with S. aureus bacteremia may have a reduced mortality risk compared to non-carriers. A role for the immune system is suggested. Here, we study in mice the effect of mild S. aureus skin infection prior to endogenous or exogenous S. aureus bacteremia, and ev

  7. [Protein toxins of Staphylococcus aureus].

    Science.gov (United States)

    Shamsutdinov, A F; Tiurin, Iu A

    2014-01-01

    Main scientific-research studies regarding protein bacterial toxins of the most widespread bacteria that belong to Staphylococcus spp. genus and in particular the most pathogenic species for humans--Staphylococcus aureus, are analyzed. Structural and biological properties of protein toxins that have received the name of staphylococcus pyrogenic toxins (PTSAg) are presented. Data regarding genetic regulation of secretion and synthesis of these toxins and 3 main regulatory genetic systems (agr--accessory gene regulator, xpr--extracellular protein regulator, sar--staphylococcal accessory regulator) that coordinate synthesis of the most important protein toxins and enzymes for virulence of S. aureus, are presented.

  8. A comparison of simulated precipitation by hybrid isentropic-sigma and sigma models

    Science.gov (United States)

    Johnson, Donald R.; Zapotocny, Tom H.; Reames, Fred M.; Wolf, Bart J.; Pierce, R. B.

    1993-01-01

    Simulations of dry and moist baroclinic development from 10- and 22-layer hybrid isentropic-sigma coordinate models are compared with those from 11-, 27-, and 35-layer sigma coordinate models. The ability of the models to transport water vapor and simulate equivalent potential temperature is examined. Predictions of the timing, location, and amount of precipitation are compared. Several analytical distributions of water vapor are specified initially. It is shown that when the relative humidity is vertically uniform through a substantial extent of the atmosphere, all the models produce very similar precipitation distributions. However, when water vapor is confined to relatively shallow layers, the ability of the sigma coordinate models to simulate the timing, location, and amount of precipitation is severely compromised.

  9. Prevention of Healthcare Associated Staphylococcus aureus Infections

    NARCIS (Netherlands)

    L.G.M. Bode (Lonneke)

    2014-01-01

    markdownabstract__Abstract__ S. aureus colonizes the skin and mucosae of a proportion of the human population. Carriers of S. aureus are at increased risk of developing infections with this pathogen. The aim of this thesis was to add to the prevention of healthcare associated S. aureus infections.

  10. Study ofe+e- to Lambda anti-Lambda, Lambda anti-Sigma^0,Sigma^0 anti-Sigma^0 using Initial State Radiation with BaBar

    Energy Technology Data Exchange (ETDEWEB)

    Aubert, B.

    2007-09-14

    We study the e+e- --> Lambda anti-Lambda gamma, Lambda anti-Sigma0 gamma, Sigma0 anti-Sigma0 gamma processes using 230 fb-1 of integrated luminosity collected by the BaBar detector at e+e- center-of-mass energy of 10.58 GeV. From the analysis of the baryon-antibaryon mass spectra the cross sections for e+e- --> Lambda anti-Lambda, Lambda anti-Sigma0, Sigma0 anti-Sigma0 are measured in the dibaryon mass range from threshold up to 3 GeV/c{sup 2}. The ratio of electric and magnetic form factors, |G{sub E}/G{sub M}|, is measured for e+e- --> Lambda anti-Lambda, and limits on the relative phase between Lambda form factors are obtained. We also measure the J/psi --> Lambda anti-Lambda, Sigma0 anti-Sigma0 and psi(2S) --> Lambda anti-Lambda branching fractions.

  11. Dermatology case: segmental lichen aureus

    OpenAIRE

    Fernandes, I.; S. Carvalho; Machado, S.; Alves,R.; Selores, M.

    2012-01-01

    ABSTRACT The authors describe a clinical case of a six-year-old boy with history of a segmental brownish maculopapular skin eruption on his left thoracic and lumbar wall, since the last four months. Based on clinical and histological findings he was diagnosed with segmental lichen aureus.

  12. Poisson sigma models and deformation quantization

    CERN Document Server

    Cattaneo, A S; Cattaneo, Alberto S.; Felder, Giovanni

    2001-01-01

    This is a review aimed at a physics audience on the relation between Poisson sigma models on surfaces with boundary and deformation quantization. These models are topological open string theories. In the classical Hamiltonian approach, we describe the reduced phase space and its structures (symplectic groupoid), explaining in particular the classical origin of the non-commutativity of the string end-point coordinates. We also review the perturbative Lagrangian approach and its connection with Kontsevich's star product. Finally we comment on the relation between the two approaches.

  13. F-theory and linear sigma models

    CERN Document Server

    Bershadsky, M; Greene, Brian R; Johansen, A; Lazaroiu, C I

    1998-01-01

    We present an explicit method for translating between the linear sigma model and the spectral cover description of SU(r) stable bundles over an elliptically fibered Calabi-Yau manifold. We use this to investigate the 4-dimensional duality between (0,2) heterotic and F-theory compactifications. We indirectly find that much interesting heterotic information must be contained in the `spectral bundle' and in its dual description as a gauge theory on multiple F-theory 7-branes. A by-product of these efforts is a method for analyzing semistability and the splitting type of vector bundles over an elliptic curve given as the sheaf cohomology of a monad.

  14. String Field Equations from Generalized Sigma Model

    Energy Technology Data Exchange (ETDEWEB)

    Bardakci, K.; Bernardo, L.M.

    1997-01-29

    We propose a new approach for deriving the string field equations from a general sigma model on the world-sheet. This approach leads to an equation which combines some of the attractive features of both the renormalization group method and the covariant beta function treatment of the massless excitations. It has the advantage of being covariant under a very general set of both local and non-local transformations in the field space. We apply it to the tachyon, massless and first massive level, and show that the resulting field equations reproduce the correct spectrum of a left-right symmetric closed bosonic string.

  15. CP Violation in the Linear Sigma Model

    CERN Document Server

    Mizher, Ana Júlia

    2009-01-01

    Motivated by the possibility of the formation of CP-odd domains in heavy ion collisions, we investigate the effects of CP violation on the chiral transition within the linear sigma model with two flavors of quarks. We also study how the CP-odd system is affected by the presence of a strong magnetic field, that is presumably generated in a non-central heavy ion collision. We find that both ingredients play an important role, influencing drastically the nature of the phase transition and the critical temperature.

  16. CP Violation in the Linear Sigma Model

    OpenAIRE

    Mizher, Ana Júlia; Fraga, Eduardo S.

    2008-01-01

    Motivated by the possibility of the formation of CP-odd domains in heavy ion collisions, we investigate the effects of CP violation on the chiral transition within the linear sigma model with two flavors of quarks. We also study how the CP-odd system is affected by the presence of a strong magnetic field, that is presumably generated in a non-central heavy ion collision. We find that both ingredients play an important role, influencing drastically the nature of the phase transition and the cr...

  17. CP Violation in the Linear Sigma Model

    Energy Technology Data Exchange (ETDEWEB)

    Mizher, Ana Julia; Fraga, Eduardo S. [Instituto de Fisica, Universidade Federal do Rio de Janeiro, Caixa Postal 68528, Rio de Janeiro, RJ 21941-972 (Brazil)

    2009-04-01

    Motivated by the possibility of the formation of CP-odd domains in heavy ion collisions, we investigate the effects of CP violation on the chiral transition within the linear sigma model with two flavors of quarks. We also study how the CP-odd system is affected by the presence of a strong magnetic field, that is presumably generated in a non-central heavy ion collision. We find that both ingredients play an important role, influencing drastically the nature of the phase transition and the critical temperature.

  18. MCRG Flow for the nonlinear Sigma Model

    CERN Document Server

    Koerner, Daniel; Wipf, Andreas

    2013-01-01

    A study of the renormalization group flow in the three-dimensional nonlinear O(N) sigma model using Monte Carlo Renormalization Group (MCRG) techniques is presented. To achieve this, we combine an improved blockspin transformation with the canonical demon method to determine the flow diagram for a number of different truncations. Systematic errors of the approach are highlighted. Results are discussed with hindsight on the fixed point structure of the model and the corresponding critical exponents. Special emphasis is drawn on the existence of a nontrivial ultraviolet fixed point as required for theories modeling the asymptotic safety scenario of quantum gravity.

  19. QCD strings as constrained grassmannian sigma model

    CERN Document Server

    Viswanathan, K S; Viswanathan, K S; Parthasarathy, R

    1995-01-01

    We present calculations for the effective action of string world sheet in R3 and R4 utilizing its correspondence with the constrained Grassmannian sigma model. Minimal surfaces describe the dynamics of open strings while harmonic surfaces describe that of closed strings. The one-loop effective action for these are calculated with instanton and anti-instanton background, reprsenting N-string interactions at the tree level. The effective action is found to be the partition function of a classical modified Coulomb gas in the confining phase, with a dynamically generated mass gap.

  20. Lean Six Sigma Projects and IT

    Institute of Scientific and Technical Information of China (English)

    Gyula Mosoni; Chee-Cheng Chen

    2013-01-01

    Lean Six Sigma operations capitalizing on the benefits of using IT follow the same principle as other process improvement methods where the main goals are maximizing the value, eliminating waste, and minimizing defects. If the transformation has been planned in the appropriate way, customer satisfaction should become higher (e.g., easier to use the web site, safer payment process, shorter waiting time)and the operations will generally be smoother; as a result, the company should be on track to becoming more profitable.

  1. Binding characteristics of sigma2 receptor ligands Características estruturais de ligantes do receptor sigma2

    Directory of Open Access Journals (Sweden)

    Richard A. Glennon

    2005-03-01

    Full Text Available Sigma (sigma receptors, once considered a type of opioid receptor, are now recognized as representing a unique receptive entity and at least two different types of sigma receptors have been identified: sigma1 and sigma2 receptors. Evidence suggests that these receptors might be targeted and exploited for the development of agents potentially useful for the treatment of several central disorders. This review primarily describes some of our efforts to understand those structural features that contribute to sigma2 receptor binding, and some recent work by other investigators is also included. Despite an inability to formulate a unified pharmacophore model for sigma2 binding due to the diversity of structure-types that bind at the receptor, and to the conformational flexibility of these ligands, significant progress has been made toward the development of some very high-affinity agents.Receptores sigma (sigma, considerados como um tipo de receptor opióide, sigma ão hoje considerados como uma entidade receptora singular. Pelo menos dois subtipos desses receptores foram identificados: sigma1e sigma2. Há evidências de que esses receptores devam ser explorados como alvo para o desenvolvimento de agentes potencialmente úteis para o tratamento de várias disfunções centrais. Esta revisão descreve, principalmente, alguns dos nossos esforços para compreender as características estruturais que contribuem para a ligação no receptor sigma2 , e incluem-se alguns trabalhos recentes desenvolvidos por outros pesquisadores. Apesar da incapacidade de formular um modelo de farmacóforo único para ligação no receptor s 2, em razão da diversidade de estruturas que a ele se ligam e da flexibilidade conformacional desses ligantes, houve progresso significativo no desenvolvimento de agentes de alta afinidade.

  2. Properties of the sigma meson at finite temperature

    Science.gov (United States)

    Ibarra, J. R. Morones; Aguirre, A. J. Garza; Flores-Baez, Francisco V.

    2015-12-01

    We study the changes of the mass and width of the sigma meson in the framework of the Linear Sigma Model at finite temperature, in the one-loop approximation. We have found that as the temperature increases, the mass of sigma shifts down. We have also analyzed the σ-spectral function and we observe an enhancement at the threshold which is a signature of partial restoration of chiral symmetry, also interpreted as a tendency to chiral phase transition. Additionally, we studied the width of the sigma, when the threshold enhancement takes place, for different values of the sigma mass. We found that there is a brief enlargement followed by an abrupt fall in the width as the temperature increases, which is also related with the restoration of chiral symmetry and an indication that the sigma is a bound state of two pions.

  3. Precise measurement of the {Sigma}{sup 0} mass

    Energy Technology Data Exchange (ETDEWEB)

    Wang, M.H.; Hartouni, E.P.; Kreisler, M.N.; Uribe, J. [Department of Physics and Astronomy, University of Massachusetts, Amherst, Massachusetts 01003 (United States); Church, M.D.; Gottschalk, E.E.; Knapp, B.C.; Stern, B.J.; Wiencke, L.R. [Columbia University, Nevis Laboratories, Irvington, New York 10533 (United States); Christian, D.C.; Gutierrez, G.; Wehmann, A. [Fermilab, Batavia, Illinois 60510 (United States); Avilez, C.; Felix, J.; Moreno, G. [Instituto de Fisica, Universidad de Guanajuato, 37150 Leon, Guanajuato (Mexico); Forbush, M.; Huson, F.R.; White, J.T. [Department of Physics, Texas AM University, College Station, Texas 77843 (United States)

    1997-09-01

    We have obtained precise measurements of the {Sigma}{sup 0} mass and the {Sigma}{sup 0}-{Lambda}{sup 0} mass difference from a fit to the {Lambda}{sup 0}{gamma} invariant mass distribution of 3327 {Sigma}{sup 0}{r_arrow}{Lambda}{sup 0}+{gamma} decays. Our measurements yield M{sub {Sigma}{sup 0}}=1192.65{plus_minus}0.020{plus_minus}0.014 MeV/c{sup 2} and M{sub {Sigma}{sup 0}}{minus}M{sub {Lambda}{sup 0}}=76.966{plus_minus}0.020{plus_minus}0.013 MeV/c{sup 2}, where the uncertainties are statistical and systematic in that order. This represents a significant improvement over all previous determinations and is the first direct measurement of the {Sigma}{sup 0} mass itself. {copyright} {ital 1997} {ital The American Physical Society}

  4. A Review: Six Sigma Implementation Practice in Manufacturing Industries

    Directory of Open Access Journals (Sweden)

    Riddhish Thakore

    2014-11-01

    Full Text Available Higher Productivity achievement is very crucial factor for the field of production. With the High productivity various other factors must be taken in to consideration in manufacturing industries such as global competitors, diversity in product range, lead time and customer demand in terms of quality and quantity. A new benchmark called Six Sigma has been invented for dealing with all these needs. Six sigma is a quality initiative which reduces variations in a process and helps to lower the cost of product as well as process. The objective of this paper is to review and examine the advancement and encounters of six sigma practices in Global manufacturing Industries and identify the key tools for each step in successful Six Sigma project execution. The paper also integrates the lessons learned from successful six sigma projects and their prospective applications in various manufacturing Industries. In today scenario, many global manufacturing industries operate their processes at the two to four sigma quality levels.

  5. Environmental Management System of Thermal plants: SIGMA; El sistema de gestion medioambiental de centrales termicas: SIGMA

    Energy Technology Data Exchange (ETDEWEB)

    Mateo Montoya, I.; Rodriguez Zarzalejos, A.

    1995-04-01

    SIGMA, (Sistema de Gestion Medioambiental) this Environmental Management System includes the different factors that are present in the environmental management of a conventional Thermal Plant such as: Air and Water Pollution, Hazardous Waste Management, Energy Recovery and Control of the Environmental Impact. Up to date the section Air Pollution is being developed and set up in the Thermal Plant of Meirama. (Author)

  6. Pseudomonas aeruginosa Alginate Overproduction Promotes Coexistence with Staphylococcus aureus in a Model of Cystic Fibrosis Respiratory Infection

    Science.gov (United States)

    Limoli, Dominique H.; Whitfield, Gregory B.; Kitao, Tomoe; Ivey, Melissa L.; Davis, Michael R.; Grahl, Nora; Hogan, Deborah A.; Rahme, Laurence G.; Howell, P. Lynne

    2017-01-01

    ABSTRACT While complex intra- and interspecies microbial community dynamics are apparent during chronic infections and likely alter patient health outcomes, our understanding of these interactions is currently limited. For example, Pseudomonas aeruginosa and Staphylococcus aureus are often found to coinfect the lungs of patients with cystic fibrosis (CF), yet these organisms compete under laboratory conditions. Recent observations that coinfection correlates with decreased health outcomes necessitate we develop a greater understanding of these interbacterial interactions. In this study, we tested the hypothesis that P. aeruginosa and/or S. aureus adopts phenotypes that allow coexistence during infection. We compared competitive interactions of P. aeruginosa and S. aureus isolates from mono- or coinfected CF patients employing in vitro coculture models. P. aeruginosa isolates from monoinfected patients were more competitive toward S. aureus than P. aeruginosa isolates from coinfected patients. We also observed that the least competitive P. aeruginosa isolates possessed a mucoid phenotype. Mucoidy occurs upon constitutive activation of the sigma factor AlgT/U, which regulates synthesis of the polysaccharide alginate and dozens of other secreted factors, including some previously described to kill S. aureus. Here, we show that production of alginate in mucoid strains is sufficient to inhibit anti-S. aureus activity independent of activation of the AlgT regulon. Alginate reduces production of siderophores, 2-heptyl-4-hydroxyquinolone-N-oxide (HQNO), and rhamnolipids—each required for efficient killing of S. aureus. These studies demonstrate alginate overproduction may be an important factor driving P. aeruginosa coinfection with S. aureus. PMID:28325763

  7. Using Lean Six Sigma to Accelerate CMMI (registered trademark) Implementation

    Science.gov (United States)

    2008-05-02

    Using Lean Six Sigma to Accelerate CMMI® Implementation Briefers: Diane A. Glaser Michael D. Barnett US Army CECOM LCMC SEC CMMI Coordinator...Objectives • Overview of Capability Maturity Model Integration (CMMI), Lean, and Six Sigma and how they combine in practice • Why the Army is adopting...Lean Six Sigma (LSS) • How the CECOM Software Engineering Center (SEC) intends to leverage LSS to accelerate CMMI implementation to support the

  8. Improve Environmental Management Systems by Auditing with Lean Six Sigma

    Science.gov (United States)

    2010-06-01

    to 00-00-2010 4. TITLE AND SUBTITLE Improve Environmental Management Systems by Auditing with Lean Six Sigma 5a. CONTRACT NUMBER 5b. GRANT NUMBER...Systems by Auditing with Lean Six Sigma U.S. Army Joint Munitions Command (JMC) AMSJM-ISM 1 Rock Island Arsenal Rock Island, IL 61299 UNCLASSIFIED...Anniston MilanPine Bluff McAlester Hawthorne Tooele Production Sites Depot Distribution Sites Depot Archive Sites GOGO GOCO 3 UNCLASSIFIED Lean Six Sigma EMS

  9. Geometry and duality in Supersymmetric $\\sigma$-Models

    CERN Document Server

    Curtright, T L; Zachos, C K; Curtright, Thomas; Uematsu, Tsuneo; Zachos, Cosmas

    1996-01-01

    The Supersymmetric Dual Sigma Model (SDSM) is a local field theory introduced to be nonlocally equivalent to the Supersymmetric Chiral nonlinear sigma-Model (SCM), this dual equivalence being proven by explicit canonical transformation in tangent space. This model is here reconstructed in superspace and identified as a chiral-entwined supersymmetrization of the Dual Sigma Model (DSM). This analysis sheds light on the Boson-Fermion Symphysis of the dual transition, and on the new geometry of the DSM.

  10. The sigma54 regulon (sigmulon) of Pseudomonas putida.

    Science.gov (United States)

    Cases, Ildefonso; Ussery, David W; de Lorenzo, Víctor

    2003-12-01

    sigma54 is unique among the bacterial sigma factors. Besides not being related in sequence with the rest of such factors, its mechanism of transcription initiation is completely different and requires the participation of a transcription activator. In addition, whereas the rest of the alternative sigma factors use to be involved in transcription of somehow related biological functions, this is not the case for sigma54 and many different and unrelated genes have been shown to be transcribed from sigma54-dependent promoters, ranging from flagellation, to utilization of several different carbon and nitrogen sources, or alginate biosynthesis. These genes have been characterized in many different bacterial species and, only until recently with the arrival of complete genome sequences, we have been able to look at the sigma54 functional role from a genomic perspective. Aided by computational methods, the sigma54 regulon has been studied both in Escherichia coli, Salmonella typhimurium and several species of the Rhizobiaceae. Here we present the analysis of the sigma54 regulon (sigmulon) in the complete genome of Pseudomonas putida KT2440. We have developed an improved method for the prediction of sigma54-dependent promoters which combines the scores of sigma54-RNAP target sequences and those of activator binding sites. In combination with other evidence obtained from the chromosomal context and the similarity with closely related bacteria, we have been able to predict more than 80% of the sigma54-dependent promoters of P. putida with high confidence. Our analysis has revealed new functions for sigma54 and, by means of comparative analysis with the previous studies, we have drawn a potential mechanism for the evolution of this regulatory system.

  11. Machine Process Capability Information Through Six Sigma

    Energy Technology Data Exchange (ETDEWEB)

    Lackner, M.F.

    1998-03-13

    A project investigating details concerning machine process capability information and its accessibility has been conducted. The thesis of the project proposed designing a part (denoted as a machine capability workpiece) based on the major machining features of a given machine. Parts are machined and measured to gather representative production, short-term variation. The information is utilized to predict the expected defect rate, expressed in terms of a composite sigma level process capability index, for a production part. Presently, decisions concerning process planning, particularly what machine will statistically produce the minimum amount of defects based on machined features and associated tolerances, are rarely made. Six sigma tools and methodology were employed to conduct this investigation at AlliedSignal FM and T. Tools such as the thought process map, factor relationship diagrams, and components of variance were used. This study is progressing toward completion. This research study was an example of how machine process capability information may be gathered for milling planar faces (horizontal) and slot features. The planning method used to determine where and how to gather variation for the part to be designed is known as factor relationship diagramming. Components-of-variation is then applied to the gathered data to arrive at the contributing level of variation illustrated within the factor relationship diagram. The idea of using this capability information beyond process planning to the other business enterprise operations is proposed.

  12. Differential Poisson Sigma Models with Extended Supersymmetry

    CERN Document Server

    Arias, Cesar; Torres-Gomez, Alexander

    2016-01-01

    The induced two-dimensional topological N=1 supersymmetric sigma model on a differential Poisson manifold M presented in arXiv:1503.05625 is shown to be a special case of the induced Poisson sigma model on the bi-graded supermanifold T[0,1]M. The bi-degree comprises the standard N-valued target space degree, corresponding to the form degree on the worldsheet, and an additional Z-valued fermion number, corresponding to the degree in the differential graded algebra of forms on M. The N=1 supersymmetry stems from the compatibility between the (extended) differential Poisson bracket and the de Rham differential on M. The latter is mapped to a nilpotent vector field Q of bi-degree (0,1) on T*[1,0](T[0,1]M), and the covariant Hamiltonian action is Q-exact. New extended supersymmetries arise as inner derivatives along special bosonic Killing vectors on M that induce Killing supervector fields of bi-degree (0,-1) on T*[1,0](T[0,1]M).

  13. Ionic rotational branching ratios in resonant enhanced multiphoton ionization of NO via the A2Sigma(+)(3s sigma) and D2Sigma(+)(3p sigma) states

    Science.gov (United States)

    Rudolph, H.; McKoy, V.; Dixit, S. N.; Huo, W. M.

    1988-01-01

    Results are presented for the rotationally resolved photoelectron spectra resulting from a (2 + 1) one-color resonant enhanced multiphoton ionization (REMPI) of NO via the rotationally clean S21(11.5) and mixed S11(15.5) + R21(15.5) branches of the 0-0 transition in the D-X band. The calculations were done in the fixed-nuclei frozen core approximation. The resulting photoionization spectra, convoluted with a Lorentzian detection function, agree qualitatively with experimental results of Viswanathan et al. (1986) and support their conclusion that the nonspherical nature of the molecular potential creates a substantial l-mixing in the continuum, which in turn leads to the intense Delta N = 0 peak. The rather strong photoelectron energy dependence of the rotational branching ratios of the D 2Sigma(+) S21(11.5) line was investigated and compared to the weak energy dependence of the A 2Sigma(+) R22(21.5) line.

  14. Sigma A recognition sites in the Bacillus subtilis genome

    DEFF Research Database (Denmark)

    Jarmer, Hanne Østergaard; Larsen, Thomas Schou; Krogh, Anders Stærmose

    2001-01-01

    A hidden Markov model of sigma (A) RNA polymerase cofactor recognition sites in Bacillus subtilis, containing either the common or the extended -10 motifs, has been constructed based on experimentally verified sigma (A) recognition sites. This work suggests that more information exists at the ini......A hidden Markov model of sigma (A) RNA polymerase cofactor recognition sites in Bacillus subtilis, containing either the common or the extended -10 motifs, has been constructed based on experimentally verified sigma (A) recognition sites. This work suggests that more information exists...

  15. Mucosal vaccination by adenoviruses displaying reovirus sigma 1

    Energy Technology Data Exchange (ETDEWEB)

    Weaver, Eric A. [Department of Internal Medicine, Division of Infectious Diseases, Translational Immunovirology and Biodefense Program, Mayo Clinic, Rochester, MN 55902 (United States); Camacho, Zenaido T. [Department of Cell Biology, Department of Natural Sciences, Western New Mexico University, Silver City, NM 88062 (United States); Hillestad, Matthew L. [Nephrology Training Program, Mayo Clinic, Rochester, MN 55902 (United States); Crosby, Catherine M.; Turner, Mallory A.; Guenzel, Adam J.; Fadel, Hind J. [Virology and Gene Therapy Graduate Program, Mayo Clinic, Rochester, MN 55902 (United States); Mercier, George T. [Department of Physics, University of Houston, Houston, TX 77004 (United States); Barry, Michael A., E-mail: mab@mayo.edu [Department of Internal Medicine, Division of Infectious Diseases, Translational Immunovirology and Biodefense Program, Mayo Clinic, Rochester, MN 55902 (United States); Department of Immunology and Department of Molecular Medicine, Mayo Clinic, Rochester, MN 55902 (United States)

    2015-08-15

    We developed adenovirus serotype 5 (Ad5) vectors displaying the sigma 1 protein from reovirus as mucosal vaccines. Ad5-sigma retargets to JAM-1 and sialic acid, but has 40-fold reduced gene delivery when compared to Ad5. While weaker at transduction, Ad5-sigma generates stronger T cell responses than Ad5 when used for mucosal immunization. In this work, new Ad5-fiber-sigma vectors were generated by varying the number of fiber β-spiral shaft repeats (R) between the fiber tail and sigma. Increasing chimera length led to decreasing insertion of these proteinsAd5 virions. Ad-R3 and R14 vectors effectively targeted JAM-1 in vitro while R20 did not. When wereused to immunize mice by the intranasal route, Ad5-R3-sigma produced higher serum and vaginal antibody responses than Ad5. These data suggest optimized Ad-sigma vectors may be useful vectors for mucosal vaccination. - Highlights: • Constructed adenoviruses (Ads) displaying different reovirus sigma 1 fusion proteins. • Progressively longer chimeras were more poorly encapsidated onto Ad virions. • Ad5-R3-sigma mediated better systemic and mucosal immune responses than Ad5.

  16. First Observation of the $\\Sigma_{c}^{*+}$ Baryon and a New Measurement of the $\\Sigma_{c}^{+}$ Mass

    CERN Document Server

    Ammar, R; Besson, D; Davis, R; Kwak, N; Zhao, X; Anderson, S; Frolov, V V; Kubota, Y; Lee, S J; Mahapatra, R; O'Neill, J J; Poling, R A; Riehle, T; Smith, A; Stepaniak, C J; Urheim, J; Ahmed, S; Alam, M S; Athar, S B; Jian, L; Ling, L; Saleem, M; Timm, S; Wappler, F; Anastassov, A; Duboscq, J E; Eckhart, E; Gan, K K; Gwon, C; Hart, T; Honscheid, K; Hufnagel, D; Kagan, H; Kass, R; Pedlar, T K; Schwarthoff, H; Thayer, J B; Von Törne, E; Zoeller, M M; Richichi, S J; Severini, H; Skubic, P L; Undrus, A; Chen, S; Fast, J; Hinson, J W; Lee, J; Miller, D H; Shibata, E I; Shipsey, I P J; Pavlunin, V; Cronin-Hennessy, D; Lyon, A L; Thorndike, E H; Jessop, C P; Marsiske, H; Perl, Martin Lewis; Savinov, V; Zhou, X; Coan, T E; Fadeev, V; Maravin, Y; Narsky, I; Stroynowski, R; Ye, J; Wlodek, T; Artuso, M; Ayad, R; Boulahouache, C; Bukin, K; Dambasuren, E; Karamov, S; Majumder, G; Moneti, G C; Mountain, R; Schuh, S; Skwarnicki, T; Stone, S; Viehhauser, G; Wang, J C; Wolf, A; Wu, J; Kopp, S E; Mahmood, A H; Csorna, S E; Danko, I; McLean, K W; Marka, S; Xu, Z; Godang, R; Kinoshita, K; Lai, I C; Schrenk, S; Bonvicini, G; Cinabro, D; McGee, S; Perera, L P; Zhou, G J; Lipeles, E; Pappas, S P; Schmidtler, M; Shapiro, A; Sun, W M; Weinstein, A J; Würthwein, F; Jaffe, D E; Masek, G E; Paar, H P; Potter, E M; Prell, S; Sharma, V; Asner, D M; Eppich, A; Hill, T S; Morrison, R J; Briere, R A; Chen, G P; Behrens, B H; Ford, W T; Gritsan, A; Roy, J D; Smith, J G; Alexander, J P; Baker, R; Bebek, C; Berger, B E; Berkelman, K; Blanc, F; Boisvert, V; Cassel, David G; Dickson, M; Drell, P S; Ecklund, K M; Ehrlich, R; Foland, A D; Gaidarev, P B; Galik, R S; Gibbons, L K; Gittelman, B; Gray, S W; Hartill, D L; Heltsley, B K; Hopman, P I; Jones, C D; Kreinick, D L; Lohner, M; Magerkurth, A; Meyer, T O; Mistry, N B; Nordberg, E; Patterson, J R; Peterson, D; Riley, D; Thayer, J G; Urner, D; Valant-Spaight, B L; Warburton, A; Avery, P; Prescott, C; Rubiera, A I; Yelton, J; Zheng, J; Brandenburg, G; Ershov, A; Gao, Y S; Kim, D Y J; Wilson, R; Browder, T E; Li, Y; Rodríguez, J L; Yamamoto, H; Bergfeld, T; Eisenstein, B I; Ernst, J; Gladding, G E; Gollin, G D; Hans, R M; Johnson, E; Karliner, I; Marsh, M A; Palmer, M; Plager, C; Sedlack, C; Selen, M; Thaler, J J; Williams, J; Edwards, K W; Janicek, R; Patel, P M; Sadoff, A J

    2001-01-01

    Using data recorded with the CLEO II and CLEO II.V detector configurations at the Cornell Electron Storage Rings, we report the first observation and mass measurement of the $\\Sigma_c^{*+}$ charmed baryon, and an updated measurement of the mass of the $\\Sigma_c^+$ baryon. We find $M(\\Sigma_c^{*+})-M(\\Lambda_c^+)$= 231.0 +- 1.1 +- 2.0 MeV, and $M(\\Sigma_c^{+})-M(\\Lambda_c^+)$= 166.4 +- 0.2 +- 0.3 MeV, where the errors are statistical and systematic respectively.

  17. Measurement of $\\sigma_{\\mathrm{ABS}}$ and $\\sigma_{\\mathrm{CX}}$ of $\\pi^+$ on carbon by DUET

    CERN Document Server

    Guerra, E S Pinzon; Berkman, S; Cao, C; de Perio, P; Hayato, Y; Ieki, K; Ikeda, M; Kanazawa, Y; Kim, J; Kitching, P; Mahn, K; Nakaya, T; Nicholson, M; Olchanski, K; Rettie, S; Tanaka, H A; Tobayama, S; Wilking, M J; Yamauchi, T; Yen, S; Yokoyama, M

    2016-01-01

    The DUET Collaboration reports on the measurements of the absorption ($\\sigma_{\\mathrm{ABS}}$) and charge exchange ($\\sigma_{\\mathrm{CX}}$) cross sections of positively charged pions on carbon nuclei for the momentum range 201.6 MeV$/c$ to 295.1 MeV$/c$. The uncertainties on the absorption and charge exchange cross sections are $\\sim$9.5\\% and $\\sim$18\\%, respectively. The results are in good agreement with previous experiments. A covariance matrix correlating the 5 $\\sigma_{\\mathrm{ABS}}$ and 5 $\\sigma_{\\mathrm{CX}}$ measured data points is also reported

  18. PCR mutagenesis identifies a polymerase-binding sequence of sigma 54 that includes a sigma 70 homology region.

    OpenAIRE

    Tintut, Y; Gralla, J D

    1995-01-01

    Sigma 54 is a minor bacterial sigma factor that is not a member of the sigma 70 family of proteins but binds the same core RNA polymerase. Previously, we identified a region of sigma 54 that is important for binding core polymerase. In this work, PCR mutagenesis was used to identify specific amino acids important for this binding. The results show that important residues are clustered most closely in a short sequence that was previously speculated to be potentially homologous to a sequence in...

  19. A model for sigma factor competition in bacterial cells.

    Science.gov (United States)

    Mauri, Marco; Klumpp, Stefan

    2014-10-01

    Sigma factors control global switches of the genetic expression program in bacteria. Different sigma factors compete for binding to a limited pool of RNA polymerase (RNAP) core enzymes, providing a mechanism for cross-talk between genes or gene classes via the sharing of expression machinery. To analyze the contribution of sigma factor competition to global changes in gene expression, we develop a theoretical model that describes binding between sigma factors and core RNAP, transcription, non-specific binding to DNA and the modulation of the availability of the molecular components. The model is validated by comparison with in vitro competition experiments, with which excellent agreement is found. Transcription is affected via the modulation of the concentrations of the different types of holoenzymes, so saturated promoters are only weakly affected by sigma factor competition. However, in case of overlapping promoters or promoters recognized by two types of sigma factors, we find that even saturated promoters are strongly affected. Active transcription effectively lowers the affinity between the sigma factor driving it and the core RNAP, resulting in complex cross-talk effects. Sigma factor competition is not strongly affected by non-specific binding of core RNAPs, sigma factors and holoenzymes to DNA. Finally, we analyze the role of increased core RNAP availability upon the shut-down of ribosomal RNA transcription during the stringent response. We find that passive up-regulation of alternative sigma-dependent transcription is not only possible, but also displays hypersensitivity based on the sigma factor competition. Our theoretical analysis thus provides support for a significant role of passive control during that global switch of the gene expression program.

  20. The optical model potential of the $\\Sigma$ hyperon in nuclear matter

    OpenAIRE

    Dabrowski, J; Rozynek, J.

    2009-01-01

    We present our attempts to determine the optical model potential $U_\\Sigma = V_\\Sigma -iW_\\Sigma$ of the $\\Sigma$ hyperon in nuclear matter. We analyze the following sources of information on $U_\\Sigma$: $\\Sigma N$ scattering, $\\Sigma^-$ atoms, and final state interaction of $\\Sigma$ hyperons in the $(\\pi,K^+)$ and $(K^-.\\pi)$ reactions on nuclear targets. We conclude that $V_\\Sigma$ is repulsive inside the nucleus and has a shallow a tractive pocket at the nuclear surface. These features of ...

  1. Polarimetric observations of $\\sigma$ Orionis E

    CERN Document Server

    Carciofi, Alex C; Townsend, Richard H D; Bjorkman, Jon E

    2013-01-01

    Some massive stars possess strong magnetic fields that confine plasma in the circumstellar environment. These \\textit{magnetospheres} have been studied spectroscopically, photometrically and, more recently, interferometrically. Here we report on the first firm detection of a magnetosphere in continuum linear polarization, as a result of monitoring of $\\sigma$\\,Ori\\,E at the Pico dos Dias Observatory. {The non-zero intrinsic polarization indicates an asymmetric structure, whose minor elongation axis is oriented $150\\fdg0$ east of the celestial north.} A modulation of the polarization was observed, with a period of half of the rotation period, which supports the theoretical prediction of the presence of two diametrally opposed, co-rotating blobs of gas. A phase lag of -0.085 was detected between the polarization minimum and the primary minimum of the light curve, suggestive of a complex shape of the plasma clouds. We present a preliminary analysis of the data with the Rigidly Rotating Magnetosphere model, which...

  2. Orbital Solution & Fundamental Parameters of sigma Scorpii

    CERN Document Server

    North, J R; Tuthill, P G; Tango, W J; Robertson, J G

    2007-01-01

    The first orbital solution for the spectroscopic pair in the multiple star system sigma Scorpii, determined from measurements with the Sydney University Stellar Interferometer (SUSI), is presented. The primary component is of beta Cephei variable type and has been one of the most intensively studied examples of its class. The orbital solution, when combined with radial velocity results found in the literature, yields a distance of 174(+23,-18) pc, which is consistent with, but more accurate than the Hipparcos value. For the primary component we determine 18.4+/-5.4 M_sun, -4.12+/-0.34 mag and 12.7+/-1.8 R_sun for the mass, absolute visual magnitude and radius respectively. A B1 dwarf spectral type and luminosity class for the secondary is proposed from the mass determination of 11.9+/-3.1 M_sun and the estimated system age of 10 Myr.

  3. QCD monopole and sigma meson coupling

    CERN Document Server

    Iwazaki, Aiichi

    2016-01-01

    Under the assumption of the Abelian dominance in QCD, we show that chiral condensate is locally present around a QCD monopole. The appearance of the chiral condensate around a GUT monopole was shown in the previous analysis of the Rubakov effect. We apply a similar analysis to the QCD monopole. It follows that the condensation of the monopole carrying the chiral condensate leads to the chiral symmetry breaking as well as quark confinement. To realize the result explicitly, we present a phenomenological linear sigma model coupled with the monopoles, in which the monopole condensation causes the chiral symmetry breaking as well as confinement. The monopoles are assumed to be described by a model of dual superconductor. We identify the monopoles with scalar isoscalar $f_0$ mesons with masses $1400\\sim 1700$ MeV as well as dual gauge fields with $h_1$ vector mesons with masses $\\sim 1500$MeV.

  4. F-theory and linear sigma models

    Energy Technology Data Exchange (ETDEWEB)

    Bershadsky, M.; Johansen, A. [Harvard Univ., Cambridge, MA (United States). Lyman Lab. of Physics; Chiang, T.M. [Newman Laboratory of Nuclear Studies, Cornell University, Ithaca, NY 14850 (United States); Greene, B.R.; Lazaroiu, C.I. [Departments of Physics and Mathematics, Columbia University, New York, NY 10027 (United States)

    1998-09-07

    We present an explicit method for translating between the linear sigma model and the spectral cover description of SU(r) stable bundles over an elliptically fibered Calabi-Yau manifold. We use this to investigate the four-dimensional duality between (0,2) heterotic and F-theory compactifications. We indirectly find that much interesting heterotic information must be contained in the `spectral bundle` and in its dual description as a gauge theory on multiple F-theory 7-branes. A by-product of these efforts is a method for analyzing semistability and the splitting type of vector bundles over an elliptic curve given as the sheaf cohomology of a monad. (orig.) 24 refs.

  5. Factors determining Staphylococcus aureus susceptibility to photoantimicrobial chemotherapy: RsbU activity, staphyloxanthin level and membrane fluidity.

    Directory of Open Access Journals (Sweden)

    Monika Kossakowska-Zwierucho

    2016-07-01

    Full Text Available Photoantimicrobial chemotherapy (PACT constitutes a particular type of stress condition, in which bacterial cells induce a pleiotropic and as yet unexplored effect. In light of this, the key master regulators are of putative significance to the overall phototoxic outcome. In Staphylococcus aureus, the alternative sigma factor σB controls the expression of genes involved in the response to environmental stress. We show that aberration of any sigB operon genes in S. aureus USA300 isogenic mutants causes a pronounced sensitization (>5 log10 reduction in CFU drop to PACT with selected photosensitizers, namely protoporphyrin diarginate, zinc phthalocyanine and rose bengal. This effect is partly due to aberration-coupled staphyloxanthin synthesis inhibition. We identified frequent mutations in RsbU, a σB activator, in PACT-vulnerable clinical isolates of S. aureus, resulting in σB activity impairment. Locations of significant changes in protein structure (IS256 insertion, early STOP codon occurrence, substitutions A230T and A276D were shown in a theoretical model of S. aureus RsbU. As a phenotypic hallmark of PACT-vulnerable S. aureus strains, we observed an increased fluidity of bacterial cell membrane, which is a result of staphyloxanthin content and other yet unidentified factors. Our research indicates σB as a promising target of adjunctive antimicrobial therapy and suggests that enhanced cell membrane fluidity may be an adjuvant strategy in photoantimicrobial chemotherapy.

  6. Lean Six Sigma in het ziekenhuis: De beschikbaarheid van infuuspompen

    NARCIS (Netherlands)

    Does, R.J.M.M.; Kemper, B.P.H.; Koopmans, M.

    2011-01-01

    In het topklinisch ziekenhuis Medisch Spectrum Twente werd in 2008 een Lean Six Sigma-project gestart. Het doel was vermindering van operationele kosten van infuuspompen. Het is een interessant voorbeeld van Lean Six Sigma in de gezondheidszorg, omdat het laat zien dat kostenbesparing niet hoeft te

  7. An application of Lean Six Sigma in a hospital

    NARCIS (Netherlands)

    van den Heuvel, J.; Does, R.J.M.M.; de Koning, H.; Anthony, J.; Kumar, M.

    2007-01-01

    Abstract Healthcare today faces major challenges. Patients demand quality of care to be improved continuously. Insurance companies demand the lowest possible prices. Lean Six Sigma is a tool that can help healthcare providers to achieve these at least partly conflicting goals. Lean Six Sigma is an i

  8. Environmental Data Flow Six Sigma Process Improvement Savings Overview

    Energy Technology Data Exchange (ETDEWEB)

    Paige, Karen S [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2015-05-20

    An overview of the Environmental Data Flow Six Sigma improvement project covers LANL’s environmental data processing following receipt from the analytical laboratories. The Six Sigma project identified thirty-three process improvements, many of which focused on cutting costs or reducing the time it took to deliver data to clients.

  9. Application of Six Sigma Method to EMS Design

    Science.gov (United States)

    Rusko, Miroslav; Králiková, Ružena

    2011-01-01

    The Six Sigma method is a complex and flexible system of achieving, maintaining and maximizing the business success. Six Sigma is based mainly on understanding the customer needs and expectation, disciplined use of facts and statistics analysis, and responsible approach to managing, improving and establishing new business, manufacturing and service processes.

  10. Conversations with Early Leaders of Eta Sigma Gamma

    Science.gov (United States)

    Clark, Jeffrey K.; Seabert, Denise M.; Goldsmith, Mal

    2007-01-01

    Anniversaries are often a time to reflect on the past. With that in mind, interviews were conducted with early key leaders of Eta Sigma Gamma to explore their perspectives of the organization's growth and development as well as their hopes for the future of ESG. The individuals interviewed included the surviving founders of Eta Sigma Gamma, the…

  11. The sigma(54) regulon (sigmulon) of Pseudomonas putida

    DEFF Research Database (Denmark)

    Cases, I.; Ussery, David; de Lorenzo, V.

    2003-01-01

    , the sigma(54) regulon has been studied both in Escherichia coli, Salmonella typhimurium and several species of the Rhizobiaceae. Here we present the analysis of the sigma(54) regulon (sigmulon) in the complete genome of Pseudomonas putida KT2440. We have developed an improved method for the prediction...

  12. Kaluza-Klein monopoles and gauged sigma-models

    NARCIS (Netherlands)

    Bergshoeff, E; Janssen, B; Ortin, T; Alvarez-Gaumé, L.

    1997-01-01

    We propose an effective action for the eleven-dimensional (bosonic) Kaluza-Klein monopole solution. The construction of the action requires that the background fields admit an Abelian isometry group. The corresponding sigma-model is gauged with respect to this isometry. The gauged sigma-model is the

  13. Studi Implementasi Six Sigma dalam Sistem Inventori Galangan Kapal

    Directory of Open Access Journals (Sweden)

    Elwin Elwin

    2012-09-01

    Full Text Available Dalam industri galangan kapal terdapat bahan baku, barang dalam proses dan barang jadi yang merupakan macam-macam bentuk dari persediaan dan berhubungan dengan stok, ketika persediaan tidak dikelola dengan benar maka akan terjadi pembengkakkan biaya/pengeluaran biaya yang tidak dibutuhkan. Tugas akhir ini bertujuan untuk mengetahui kondisi inventori di PT. Dok dan Perkapalan Surbaya, untuk mengetahui faktor-faktor yang menjadi penyebab terjadinya variabilitas output six sigma dan mengurangi defect pada sistem inventori dengan menggunakan metode six sigma DMAIC (Define, Measure, Analyze, Improve dan Control,. Berdasarkan perhitungan Material Pipa mengalami defect sebesar 50.98% dengan nilai sigma 1.48, Material Elbow mengalami defect sebesar 89.80% dengan nilai sigma 0.33, Material Flange mengalami defect sebesar 71.99% dengan nilai sigma 0.90, Material Paking mengalami defect sebesar 13.12% dengan nilai sigma 2.74 dan Material Mur mengalami defect sebesar 17.26% dengan nilai sigma 2.57. Sesuai dengan perhitungan reorder point for the inventory untuk masing-masing material, maka dapat diketahui bahwa material Pipa reoder point adalah 58 lonjor, elbow 100 buah, flange 168 buah, paking 24 buah dan mur 946 buah. Nilai sigma yang diperoleh dalam perhitungan tingkat persediaan masih jauh dari nilai yang seharusnya dapat dicapai oleh suatu perusahaan (6σ, sehingga dilakukan tahap Improve dengan metode Failure Mode and Effect Analysis (FMEA, pembuat SOP Pengendalian persediaan material dengan format baru serta galangan perlu melakukan perhitungan reorder point.  

  14. Kaluza-Klein Monopoles and Gauged Sigma Models

    NARCIS (Netherlands)

    Bergshoeff, E.A.

    1998-01-01

    We review some aspects of branes. In particular, we discuss the worldvolume theory describing the dynamics of the Kaluza-Klein monopole which turns out to be a gauged sigma model. We also briefly review some recent applications of gauged sigma models to the worldvolume description of massive branes,

  15. Wess Zumino Couplings for Generalized Sigma Orbifold Fixed-points

    OpenAIRE

    Giraldo, Juan Fernando Ospina

    2000-01-01

    The Wess-Zumino couplings for generalized sigma-orbifold fixed-points are presented and the generalized GS 6-form that encoding the complete sigma-standard gauge-gravitational-non standard gauge anomaly and its opposite inflow is derived.

  16. Wess Zumino Couplings for Generalized $\\Sigma$ Orbifold Fixed-points

    CERN Document Server

    Ospina-Giraldo, J F

    2000-01-01

    The Wess-Zumino couplings for generalized sigma-orbifold fixed-points are presented and the generalized GS 6-form that encoding the complete sigma-standard gauge-gravitational-non standard gauge anomaly and its opposite inflow is derived.

  17. Inspanning om Lean Six Sigma op kaart te zetten beloond

    NARCIS (Netherlands)

    Does, R.J.M.M.

    2008-01-01

    Prof.dr. R.J.M.M. Does is al jarenlang een fervent voorvechter voor het gebruik van statistiek. En meer recent is hij zo’n beetje de belichaming van (Lean) Six Sigma in Europa. Tal van grote organisaties hebben hem te hulp geroepen bij de invoering van (Lean) Six Sigma. Het is dan ook niet meer dan

  18. Decays of Baryon Resonances into K Lambda, K^+ Sigma^0 and K^0 Sigma^+

    CERN Document Server

    Sarantsev, A V; Anisovich, A V; Klempt, E; Thoma, U

    2005-01-01

    Cross sections, beam asymmetries, and recoil polarisations for the reactions gamma p to K^+ Lambda ; gamma to K^+ Sigma^0, and gamma p to K^0 Sigma^+ have been measured by the SAPHIR, CLAS, and LEPS collaborations with high statistics and good angular coverage for centre-of-mass energies between 1.6 and 2.3 GeV. The combined analysis of these data with data from pi and eta photoproduction reveals evidence for new baryon resonances in this energy region. A new P_{11} state with mass 1840 MeV and width 140 MeV was observed contributing to most of the fitted reactions. The data demand the presence of two D_{13} states at 1870 and 2170 MeV.

  19. SIGMA Final Report: Volume V, Part 4. The Design of SIGMA.

    Science.gov (United States)

    1982-05-01

    sender , subject, date/time stamp, etc.--so that the message behind it is identifiable. It also specifies the nature of transmission, whether a message is...number, the new mail and alert counts, the load aerage, and the time of day. is generated and sent to the Driver. - Ithe user queue is not empty. the...deletes folders from the SIGMA folder database (DELETE-FOLDER). " It updates folders with delta file information (DELTA-UPDATE). * It creates inboxes

  20. Evasion of Neutrophil Killing by Staphylococcus aureus

    Directory of Open Access Journals (Sweden)

    Will A. McGuinness

    2016-03-01

    Full Text Available Staphylococcus aureus causes many types of infections, ranging from self-resolving skin infections to severe or fatal pneumonia. Human innate immune cells, called polymorphonuclear leukocytes (PMNs or neutrophils, are essential for defense against S. aureus infections. Neutrophils are the most prominent cell type of the innate immune system and are capable of producing non-specific antimicrobial molecules that are effective at eliminating bacteria. Although significant progress has been made over the past few decades, our knowledge of S. aureus-host innate immune system interactions is incomplete. Most notably, S. aureus has the capacity to produce numerous molecules that are directed to protect the bacterium from neutrophils. Here we review in brief the role played by neutrophils in defense against S. aureus infection, and correspondingly, highlight selected S. aureus molecules that target key neutrophil functions.

  1. Lean six sigma case studies in the healthcare enterprise

    CERN Document Server

    Furterer, Sandra L

    2014-01-01

    This book provides a detailed description of how to apply Lean Six Sigma in the health care industry, with a special emphasis on process improvement and operations management in hospitals.  The book begins with a description of the Enterprise Performance Excellence (EPE) improvement methodology developed by the author that links several methodologies including systems thinking, theory of constraints, Lean and Six Sigma to provide an enterprise-wide prioritization and value-chain view of health care. The EPE methodology helps to improve flow at the macro or value-chain level, and then identifies Lean Six Sigma detailed improvements that can further improve processes within the value-chain.  The book also provides real-world health care applications of the EPE and Lean Six Sigma methodologies that showed significant results on throughput, capacity, operational and financial performance. The Enterprise Performance Excellence methodology is described, and also the Six Sigma DMAIC (Define-Measure-Analyze-Improve...

  2. The LHCb pentaquark as a $\\bar{D}^*\\Sigma_c-\\bar{D}^*\\Sigma_c^*$ molecular state

    CERN Document Server

    Roca, L; Oset, E

    2015-01-01

    We perform a theoretical analysis of the $\\Lambda_b \\to J/\\psi K^- p$ reaction from where a recent LHCb experiment extracts a $\\Lambda(1405)$ contribution in the $K^- p$ spectrum close to threshold and two baryon states of hidden charm in the $J/\\psi\\,p$ spectrum. We recall that baryon states of this type have been theoretically predicted matching the mass, width and $J^P$ of the experiment, concretely some states built up from the $J/\\psi\\, N$, $\\bar D^* \\Lambda_c$, $\\bar D^* \\Sigma_c$, $\\bar D \\Sigma^*_c$ and $\\bar D^* \\Sigma^*_c$ coupled channels. We assume that the observed narrow state around 4450 MeV has this nature and we are able to describe simultaneously the shapes and relative strength of the the $K^- p$ mass distribution close to threshold and the peak of the $J/\\psi\\,p$ distribution, with values of the $J/\\psi\\, p$ coupling to the resonance in line with the theoretical ones. The non trivial matching of many properties gives support to a $J^P=3/2^-$ assignment to this state and to its nature as a ...

  3. Postoperative Staphylococcus aureus infections in Medicare beneficiaries.

    Directory of Open Access Journals (Sweden)

    Moaven Razavi

    Full Text Available Staphylococcus aureus (S. aureus infections are important because of their increasing frequency, resistance to antibiotics, and high associated rates of disabilities and deaths. We examined the incidence and correlates of S. aureus infections following 219,958 major surgical procedures in a 5% random sample of fee-for-service Medicare beneficiaries from 2004-2007. Of these surgical patients, 0.3% had S. aureus infections during the hospitalizations when index surgical procedures were performed; and 1.7% and 2.3%, respectively, were hospitalized with infections within 60 days or 180 days following admissions for index surgeries. S. aureus infections occurred within 180 days in 1.9% of patients following coronary artery bypass graft surgery, 2.3% following hip surgery, and 5.9% following gastric or esophageal surgery. Of patients first hospitalized with any major infection reported during the first 180 days after index surgery, 15% of infections were due to S. aureus, 18% to other documented organisms, and no specific organism was reported on claim forms in 67%. Patient-level predictors of S. aureus infections included transfer from skilled nursing facilities or chronic hospitals and comorbid conditions (e.g., diabetes, congestive heart failure, chronic obstructive pulmonary disease, and chronic renal disease. In a logarithmic regression, elective index admissions with S. aureus infection stayed 130% longer than comparable patients without that infection. Within 180 days of the index surgery, 23.9% of patients with S. aureus infection and 10.6% of patients without this infection had died. In a multivariate logistic regression of death within 180 days of admission for the index surgery with adjustment for demographics, co-morbidities, and other risks, S. aureus was associated with a 42% excess risk of death. Due to incomplete documentation of organisms in Medicare claims, these statistics may underestimate the magnitude of S. aureus infection

  4. Six Sigma. Quality initiatives for cost reduction and process optimisation; Six Sigma. Qualitaetsinitiative zur Kostenreduzierung und Prozessoptimierung

    Energy Technology Data Exchange (ETDEWEB)

    Boerkircher, Mikko [Rheinkalk GmbH, Flandersbach (Germany). Bereich Brennen und Verdeln

    2010-06-15

    Six Sigma occupies an important position in management practice. An increasing number of companies have recognised that this quality approach is not only an effective lever in order to reduce the costs of errors. In addition Six Sigma imparts important momentum to customer satisfaction and commitment, which is likewise reflected in increasing income and turnover. (orig.)

  5. A comparison of regional isentropic-sigma and sigma model simulations of the January 1979 Chicago blizzard

    Science.gov (United States)

    Zapotocny, Tom H.; Johnson, Donald R.; Reames, Fred M.

    1993-01-01

    In an initial effort in regional numerical weather prediction, results from the University of Wisconsin isentropic-sigma (UW theta-sigma) hybrid model and an 'identical' sigma model are compared. The two main objectives are to demonstrate the capability of the UW theta-sigma model for regional numerical weather prediction and to identify advantages of the hybrid model in simulating atmospheric water vapor transport and precipitation relative to the sigma model. The 72-h simulations produced by the two models extend over a region covering the western Pacific Ocean, North America, and the western Atlantic Ocean. The simulations begin at 0000 UTC 13 January 1979, a period during which an intense Chicago blizzard develops over the central United States. This period also includes the rapid development of a cyclone in the western Pacific Ocean. Results using the Global Weather Experiment (GWE) ECMWF level IIIB data as initial and verification data indicate that both models produce reasonable and similar 72-h simulations, with the UW theta-sigma model mass and momentum distributions being slightly more accurate than the sigma model. Of particular importance for the Chicago blizzard is that the UW theta-sigma model more accurately simulates water vapor transport northward from the Gulf of Mexico and westward from the Atlantic Ocean. As a result, the hybrid model more accurately simulates observed precipitation, especially over the northeastern U.S. and southeastern Canada.

  6. CHROMOSOMAL MAPPING IN STRAINS OF STAPHYLOCOCCUS AUREUS,

    Science.gov (United States)

    STAPHYLOCOCCUS AUREUS , CHROMOSOMES), (*CHROMOSOMES, MAPPING), NITROSO COMPOUNDS, GUANIDINES, GENETICS, MUTATIONS, DRUGS, TOLERANCES(PHYSIOLOGY), TEST METHODS, DEOXYRIBONUCLEIC ACIDS, INHIBITION, RESISTANCE(BIOLOGY).

  7. Mastite com lesões sistêmicas por Staphylococus aureus subesp. aureus em coelhos Mastitis with systemic lesions due to Staphylococus aureus subesp. aureus in rabbits

    OpenAIRE

    Sandra Davi Traverso; Leonardo da Cunha; Joaquim César Teixeira Fernandes; Alexandre Paulino Loretti; Adriana Rhoden; Elsio Wunder Jr.; David Driemeier

    2003-01-01

    Em uma criação composta por 1800 coelhos, 33% das matrizes apresentaram mastite e lesões cutâneas crostosas e purulentas. Estes animais apresentavam-se entre 10 a- 12 meses de idade e em segunda parição. Quinze coelhos afetados foram sacrificados e necropsiados. Na necropsia, além das lesões cutâneas haviam microabscessos em diversos órgãos. Das amostras coletadas isolou-se Staphylococcus aureus subesp. aureus. S. aureus subesp. aureus também foi isolado de "swab" nasal coletado do tratador e...

  8. Mild Staphylococcus aureus Skin Infection Improves the Course of Subsequent Endogenous S. aureus Bacteremia in Mice.

    Directory of Open Access Journals (Sweden)

    Sanne van den Berg

    Full Text Available Staphylococcus aureus carriers with S. aureus bacteremia may have a reduced mortality risk compared to non-carriers. A role for the immune system is suggested. Here, we study in mice the effect of mild S. aureus skin infection prior to endogenous or exogenous S. aureus bacteremia, and evaluate protection in relation to anti-staphylococcal antibody levels. Skin infections once or twice by a clinical S. aureus isolate (isolate P or S. aureus strain 8325-4 were induced in mice free of S. aureus and anti-staphylococcal antibodies. Five weeks later, immunoglobulin G (IgG levels in blood against 25 S. aureus antigens were determined, and LD50 or LD100 bacteremia caused by S. aureus isolate P was induced. S. aureus skin infections led to elevated levels of anti-staphylococcal IgG in blood. One skin infection improved the course of subsequent severe endogenous bacteremia only. A second skin infection further improved animal survival rate, which was associated with increased pre-bacteremia IgG levels against Efb, IsaA, LukD, LukE, Nuc, PrsA and WTA. In conclusion, S. aureus isolate P skin infection in mice reduces the severity of subsequent endogenous S. aureus bacteremia only. Although cellular immune effects cannot be rules out, anti-staphylococcal IgG against specified antigens may contribute to this effect.

  9. Nuclease modulates biofilm formation in community-associated methicillin-resistant Staphylococcus aureus.

    Directory of Open Access Journals (Sweden)

    Megan R Kiedrowski

    Full Text Available Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA is an emerging contributor to biofilm-related infections. We recently reported that strains lacking sigma factor B (sigB in the USA300 lineage of CA-MRSA are unable to develop a biofilm. Interestingly, when spent media from a USA300 sigB mutant was incubated with other S. aureus strains, biofilm formation was inhibited. Following fractionation and mass spectrometry analysis, the major anti-biofilm factor identified in the spent media was secreted thermonuclease (Nuc. Considering reports that extracellular DNA (eDNA is an important component of the biofilm matrix, we investigated the regulation and role of Nuc in USA300. The expression of the nuc gene was increased in a sigB mutant, repressed by glucose supplementation, and was unaffected by the agr quorum-sensing system. A FRET assay for Nuc activity was developed and confirmed the regulatory results. A USA300 nuc mutant was constructed and displayed an enhanced biofilm-forming capacity, and the nuc mutant also accumulated more high molecular weight eDNA than the WT and regulatory mutant strains. Inactivation of nuc in the USA300 sigB mutant background partially repaired the sigB biofilm-negative phenotype, suggesting that nuc expression contributes to the inability of the mutant to form biofilm. To test the generality of the nuc mutant biofilm phenotypes, the mutation was introduced into other S. aureus genetic backgrounds and similar increases in biofilm formation were observed. Finally, using multiple S. aureus strains and regulatory mutants, an inverse correlation between Nuc activity and biofilm formation was demonstrated. Altogether, our findings confirm the important role for eDNA in the S. aureus biofilm matrix and indicates Nuc is a regulator of biofilm formation.

  10. Prospects for observing the lowest-lying odd-parity $\\Sigma_c$ and $\\Sigma_b$ baryons

    CERN Document Server

    Karliner, Marek

    2015-01-01

    There exist candidates for the negative-parity states $\\Lambda_{c,b}(1/2^-, 3/2^-)$ consisting of an isospin-zero, spin-zero light diquark $[ud]$ with one unit of orbital angular momentum with respect to a $c,b$ quark. However, there exists only one candidate for the orbital excitations of the $\\Sigma_c(1/2^+)$ and $\\Sigma_c^*(3/2^+)$, and none for the orbital excitations of $\\Sigma_b(1/2^+)$ or $\\Sigma_b^*(3/2^+)$. We extend a previous discussion of odd-parity $\\Lambda_{c,b}$ states and explore some patterns of the odd-parity $\\Sigma_{c,b}$ baryons consisting of a light isospin-one nonstrange diquark $(uu,ud,dd)$ in a state of $L=1$ with respect to the spin-1/2 heavy quark $(c,b)$.

  11. The $C \\: ^1 \\Sigma ^+$, $A \\: ^1 \\Sigma ^+$, and $b \\: ^3 \\Pi_{0^+}$ states of LiRb

    CERN Document Server

    Stevenson, I C; Chen, Y P; Elliott, D S

    2016-01-01

    We present the first spectroscopic studies of the $C \\ ^1\\Sigma^+$ electronic state and the $A \\ ^1\\Sigma^+$ - $b \\ ^3\\Pi_{0^+}$ complex in $^7$Li - $^{85}$Rb. Using resonantly-enhanced, two-photon ionization, we observed $v = 7$, 9, 12, 13 and $26-44$ of the $C \\ ^1\\Sigma^+$ state. We augment the REMPI data with a form of depletion spectra in regions of dense spectral lines. The $A \\ ^1\\Sigma^+$ - $b \\ ^3\\Pi_{0^+}$ complex was observed with depletion spectroscopy, depleting to vibrational levels $v=0 \\rightarrow 29$ of the $A \\ ^1\\Sigma^+$ state and $v=8 \\rightarrow 18$ of the $b \\ ^3\\Pi_{0^+}$ state. For all three series, we determine the term energy and vibrational constants. Finally, we outline several possible future projects based on the data presented here.

  12. $\\Lambda_c\\Sigma_c\\pi$ coupling and $\\Sigma_c \\rightarrow\\Lambda_c \\pi$ decay in lattice QCD

    CERN Document Server

    Can, K U; Oka, M; Takahashi, T T

    2016-01-01

    We evaluate the $\\Lambda_c\\Sigma_c\\pi$ coupling constant ($G_{\\Lambda_c \\Sigma_c \\pi}$) and the width of the strong decay $\\Sigma_c \\rightarrow\\Lambda_c \\pi$ in 2+1 flavor lattice QCD on four different ensembles with pion masses ranging from 700 MeV to 300 MeV. We find $G_{\\Lambda_c \\Sigma_c \\pi}=18.332(1.476)_{\\rm{stat.}}(2.171)_{\\rm{syst.}}$ and the decay width $\\Gamma(\\Sigma_c \\rightarrow\\Lambda_c \\pi)=1.65(28)_{\\rm{stat.}}(30)_{\\rm{syst.}}$~MeV on the physical quark-mass point, which is in agreement with the recent experimental determination.

  13. Characterisation of Staphylococcus aureus bacteraemia at Tygerberg hospital

    NARCIS (Netherlands)

    Orth, H.; Dreyer, Z.S.; Makgotlho, E.; Oosthuysen, W.; Sinha, B.; Wasserman, E.

    2013-01-01

    To elucidate the local epidemiology of Staphylococcus aureus bacteraemia, we characterised blood culture isolates using molecular methods and prospectively collected clinical data to determine the occurrence of community-acquired, methicillinresistant S. aureus (MRSA). Consecutive S. aureus blood cu

  14. Triclosan promotes Staphylococcus aureus nasal colonization.

    Science.gov (United States)

    Syed, Adnan K; Ghosh, Sudeshna; Love, Nancy G; Boles, Blaise R

    2014-04-08

    The biocide triclosan is used in many personal care products, including toothpastes, soaps, clothing, and medical equipment. Consequently, it is present as a contaminant in the environment and has been detected in some human fluids, including serum, urine, and milk. Staphylococcus aureus is an opportunistic pathogen that colonizes the noses and throats of approximately 30% of the population. Colonization with S. aureus is known to be a risk factor for several types of infection. Here we demonstrate that triclosan is commonly found in the nasal secretions of healthy adults and the presence of triclosan trends positively with nasal colonization by S. aureus. We demonstrate that triclosan can promote the binding of S. aureus to host proteins such as collagen, fibronectin, and keratin, as well as inanimate surfaces such as plastic and glass. Lastly, triclosan-exposed rats are more susceptible to nasal colonization with S. aureus. These data reveal a novel factor that influences the ability of S. aureus to bind surfaces and alters S. aureus nasal colonization. IMPORTANCE Triclosan has been used as a biocide for over 40 years, but the broader effects that it has on the human microbiome have not been investigated. We demonstrate that triclosan is present in nasal secretions of a large portion of a test population and its presence correlates with Staphylococcus aureus nasal colonization. Triclosan also promotes the binding of S. aureus to human proteins and increases the susceptibility of rats to nasal colonization by S. aureus. These findings are significant because S. aureus colonization is a known risk factor for the development of several types of infections. Our data demonstrate the unintended consequences of unregulated triclosan use and contribute to the growing body of research demonstrating inadvertent effects of triclosan on the environment and human health.

  15. An Application of Six Sigma to Reduce Supplier Quality Cost

    Science.gov (United States)

    Gaikwad, Lokpriya Mohanrao; Teli, Shivagond Nagappa; Majali, Vijay Shashikant; Bhushi, Umesh Mahadevappa

    2016-01-01

    This article presents an application of Six Sigma to reduce supplier quality cost in manufacturing industry. Although there is a wider acceptance of Six Sigma in many organizations today, there is still a lack of in-depth case study of Six Sigma. For the present research the case study methodology was used. The company decided to reduce quality cost and improve selected processes using Six Sigma methodologies. Regarding the fact that there is a lack of case studies dealing with Six Sigma especially in individual manufacturing organization this article could be of great importance also for the practitioners. This paper discusses the quality and productivity improvement in a supplier enterprise through a case study. The paper deals with an application of Six Sigma define-measure-analyze-improve-control methodology in an industry which provides a framework to identify, quantify and eliminate sources of variation in an operational process in question, to optimize the operation variables, improve and sustain performance viz. process yield with well-executed control plans. Six Sigma improves the process performance (process yield) of the critical operational process, leading to better utilization of resources, decreases variations and maintains consistent quality of the process output.

  16. Sign ambiguity in the K{Sigma} channel

    Energy Technology Data Exchange (ETDEWEB)

    Anisovich, A.V.; Nikonov, V.A.; Sarantsev, A.V. [Universitaet Bonn, Helmholtz-Institut fuer Strahlen- und Kernphysik, Bonn (Germany); Petersburg Nuclear Physics Institute, Gatchina (Russian Federation); Klempt, E.; Thoma, U. [Universitaet Bonn, Helmholtz-Institut fuer Strahlen- und Kernphysik, Bonn (Germany)

    2013-12-15

    Ambiguities of the signs of N {yields} {Sigma}K coupling constants are studied in a multichannel partial wave analysis of a large body of pion- and photo-induced reactions. It is shown that the signs are not free from some ambiguities, and further experimental data are needed. Data on the reactions {pi}{sup +} p {yields} {Sigma}{sup +} K{sup +} and {gamma}p {yields} K{sup +} {Sigma}{sup 0} define rather well the isospin 3/2 contributions to these channels. However the lack of information on polarization observables for the reactions {pi}{sup -} p {yields} {Sigma}{sup 0} K{sup 0}, {pi}{sup -} p {yields} {Sigma}{sup -} K{sup +} and {gamma}p {yields} K{sup 0} {Sigma}{sup +} does not allow us to fix uniquely the signs of N {yields} {Sigma}K coupling constants. As a consequence, also the contributions of nucleon resonances to these channels remain uncertain. (orig.)

  17. Numerical investigations on influence of B-dependent flow resistivity on third harmonics of generated magnetic field

    Energy Technology Data Exchange (ETDEWEB)

    Kamitani, Atsushi; Saitoh, Ayumu; Ikuno, Soichiro

    2004-10-01

    The numerical code for simulating the time evolution of the shielding current density in the high-temperature superconductor has been developed on the basis of the element-free Galerkin method. The magnetic flux density generated by the shielding current density is calculated by use of the code and its spectral analysis is performed. The results of computations show that an increase in the amplitude of the applied ac magnetic field will cause the appearance of the third harmonics of the magnetic flux density. Furthermore, it is found that the rapid growth of the third harmonics arises not from the B-dependence of the critical current density but from that of the flow resistivity.

  18. The sigma model on complex projective superspaces

    Energy Technology Data Exchange (ETDEWEB)

    Candu, Constantin; Mitev, Vladimir; Schomerus, Volker [DESY, Hamburg (Germany). Theory Group; Quella, Thomas [Amsterdam Univ. (Netherlands). Inst. for Theoretical Physics; Saleur, Hubert [CEA Saclay, 91 - Gif-sur-Yvette (France). Inst. de Physique Theorique; USC, Los Angeles, CA (United States). Physics Dept.

    2009-08-15

    The sigma model on projective superspaces CP{sup S-1} {sup vertical} {sup stroke} {sup S} gives rise to a continuous family of interacting 2D conformal field theories which are parametrized by the curvature radius R and the theta angle {theta}. Our main goal is to determine the spectrum of the model, non-perturbatively as a function of both parameters. We succeed to do so for all open boundary conditions preserving the full global symmetry of the model. In string theory parlor, these correspond to volume filling branes that are equipped with a monopole line bundle and connection. The paper consists of two parts. In the first part, we approach the problem within the continuum formulation. Combining combinatorial arguments with perturbative studies and some simple free field calculations, we determine a closed formula for the partition function of the theory. This is then tested numerically in the second part. There we propose a spin chain regularization of the CP{sup S-1} {sup vertical} {sup stroke} {sup S} model with open boundary conditions and use it to determine the spectrum at the conformal fixed point. The numerical results are in remarkable agreement with the continuum analysis. (orig.)

  19. Perturbation theory for string sigma models

    CERN Document Server

    Bianchi, Lorenzo

    2016-01-01

    In this thesis we investigate quantum aspects of the Green-Schwarz superstring in various AdS backgrounds relevant for the AdS/CFT correspondence, providing several examples of perturbative computations in the corresponding integrable sigma-models. We start by reviewing in details the supercoset construction of the superstring action in $AdS_5 \\times S^5$, pointing out the limits of this procedure for $AdS_4$ and $AdS_3$ backgrounds. For the $AdS_4 \\times CP^3$ case we give a thorough derivation of an alternative action, based on the double-dimensional reduction of eleven-dimensional super-membranes. We then consider the expansion about the BMN vacuum and the S-matrix for the scattering of worldsheet excitations in the decompactification limit. To evaluate its elements efficiently we describe a unitarity-based method resulting in a very compact formula yielding the cut-constructible part of any one-loop two-dimensional S-matrix. In the second part of this review we analyze the superstring action on $AdS_4 \\ti...

  20. Pseudomonas aeruginosa Alginate Overproduction Promotes Coexistence with Staphylococcus aureus in a Model of Cystic Fibrosis Respiratory Infection.

    Science.gov (United States)

    Limoli, Dominique H; Whitfield, Gregory B; Kitao, Tomoe; Ivey, Melissa L; Davis, Michael R; Grahl, Nora; Hogan, Deborah A; Rahme, Laurence G; Howell, P Lynne; O'Toole, George A; Goldberg, Joanna B

    2017-03-21

    While complex intra- and interspecies microbial community dynamics are apparent during chronic infections and likely alter patient health outcomes, our understanding of these interactions is currently limited. For example, Pseudomonas aeruginosa and Staphylococcus aureus are often found to coinfect the lungs of patients with cystic fibrosis (CF), yet these organisms compete under laboratory conditions. Recent observations that coinfection correlates with decreased health outcomes necessitate we develop a greater understanding of these interbacterial interactions. In this study, we tested the hypothesis that P. aeruginosa and/or S. aureus adopts phenotypes that allow coexistence during infection. We compared competitive interactions of P. aeruginosa and S. aureus isolates from mono- or coinfected CF patients employing in vitro coculture models. P. aeruginosa isolates from monoinfected patients were more competitive toward S. aureus than P. aeruginosa isolates from coinfected patients. We also observed that the least competitive P. aeruginosa isolates possessed a mucoid phenotype. Mucoidy occurs upon constitutive activation of the sigma factor AlgT/U, which regulates synthesis of the polysaccharide alginate and dozens of other secreted factors, including some previously described to kill S. aureus Here, we show that production of alginate in mucoid strains is sufficient to inhibit anti-S. aureus activity independent of activation of the AlgT regulon. Alginate reduces production of siderophores, 2-heptyl-4-hydroxyquinolone-N-oxide (HQNO), and rhamnolipids-each required for efficient killing of S. aureus These studies demonstrate alginate overproduction may be an important factor driving P. aeruginosa coinfection with S. aureusIMPORTANCE Numerous deep-sequencing studies have revealed the microbial communities present during respiratory infections in cystic fibrosis (CF) patients are diverse, complex, and dynamic. We now face the challenge of determining

  1. Enlisting Lean Six Sigma in the Army Acquisition Process

    Science.gov (United States)

    2008-04-01

    One of the strategic objectives of this overarching strategy is to “support Army-wide LSS [Lean Six Sigma ] and business transformation and focus on...re- sults of financial management LSS projects Army-wide.” • • • • • • I M P R O V I N G P R O C E S S E S Enlisting Lean Six Sigma in the Army...Lean Six Sigma process. The LSS process has its own methodology that can be applied to any manufacturing, transactional, or service process to reduce

  2. The minimal linear sigma model for the Goldstone Higgs

    CERN Document Server

    Feruglio, Ferruccio; Kanshin, Kirill; Machado, Pedro Accioly Nogueira; Rigolin, Stefano; Saa, Sara

    2016-01-01

    In the context of the minimal SO(5) linear {\\sigma}-model, a complete renormalizable Lagrangian -including gauge bosons and fermions- is considered, with the symmetry softly broken to SO(4). The scalar sector describes both the electroweak Higgs doublet and the singlet {\\sigma}. Varying the {\\sigma} mass would allow to sweep from the regime of perturbative ultraviolet completion to the non-linear one assumed in models in which the Higgs particle is a low-energy remnant of some strong dynamics. We analyze the phenomenological implications and constraints from precision observables and LHC data. Furthermore, we derive the d <= 6 effective Lagrangian in the limit of heavy exotic fermions.

  3. Sigma: Web Retrieval Interface for Nuclear Reaction Data

    Energy Technology Data Exchange (ETDEWEB)

    Pritychenko,B.; Sonzogni, A.A.

    2008-06-24

    The authors present Sigma, a Web-rich application which provides user-friendly access in processing and plotting of the evaluated and experimental nuclear reaction data stored in the ENDF-6 and EXFOR formats. The main interface includes browsing using a periodic table and a directory tree, basic and advanced search capabilities, interactive plots of cross sections, angular distributions and spectra, comparisons between evaluated and experimental data, computations between different cross section sets. Interactive energy-angle, neutron cross section uncertainties plots and visualization of covariance matrices are under development. Sigma is publicly available at the National Nuclear Data Center website at www.nndc.bnl.gov/sigma.

  4. Chromones from an ascomycete,Chaetomium aureus

    Institute of Scientific and Technical Information of China (English)

    Li Mei Li; Qiang Zou; Guo You Li

    2010-01-01

    A novel chromone,named chaetoaurin (1),along with six known chromone derivatives (2-7),was isolated from the ethyl acetate extract of a solid-state fermented culture of Chaetomium aureus.Their structures were elucidated by extensive spectral analysis.All of these compounds were reported from C.aureus for the first time.

  5. Immunogenicity of toxins during Staphylococcus aureus infection

    NARCIS (Netherlands)

    N.J. Verkaik (Nelianne); O. Dauwalder (Olivier); K. Antri (Kenza); I. Boubekri (Ilhem); C.P. de Vogel (Corné); C. Badiou (Cédric); M. Bes (Michèle); F. Vandenesch (François); M. Tazir (Mohammed); H. Hooijkaas (Herbert); H.A. Verbrugh (Henri); A.F. van Belkum (Alex); J. Etienne (Jerome); G. Lina (Gérard); N. Ramdani-Bouguessa (Nadjia); W.J.B. van Wamel (Willem)

    2010-01-01

    textabstractAB - BACKGROUND: Toxins are important Staphylococcus aureus virulence factors, but little is known about their immunogenicity during infection. Here, additional insight is generated. METHODS: Serum samples from 206 S. aureus-infected patients and 201 hospital-admitted control subjects we

  6. Staphylococcus aureus and hand eczema severity

    DEFF Research Database (Denmark)

    Haslund, P; Bangsgaard, N; Jarløv, J O

    2009-01-01

    BACKGROUND: The role of bacterial infections in hand eczema (HE) remains to be assessed. OBJECTIVES: To determine the prevalence of Staphylococcus aureus in patients with HE compared with controls, and to relate presence of S. aureus, subtypes and toxin production to severity of HE. METHODS......: Bacterial swabs were taken at three different visits from the hand and nose in 50 patients with HE and 50 controls. Staphylococcus aureus was subtyped by spa typing and assigned to clonal complexes (CCs), and isolates were tested for exotoxin-producing S. aureus strains. The Hand Eczema Severity Index...... was used for severity assessment. RESULTS: Staphylococcus aureus was found on the hands in 24 patients with HE and four controls (P hands...

  7. Scalar {sigma} meson effects in {rho} and {omega} decays

    Energy Technology Data Exchange (ETDEWEB)

    Bramon, A. [Universitat Autonoma de Barcelona, Dept. de Fisica, Bellaterra, Barcelona (Spain); Escribano, R. [Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali di Frascati, Rome (Italy); Lucio, J.L.M.; Napsuciale, M. [Universidad de Guanajuato, Instituto de Fisica, Leon (Mexico)

    2001-05-01

    The complementarity between Chiral Perturbation Theory and the Linear Sigma Model in the scalar channel is exploited to study {pi}{sup 0} {pi}{sup 0} production in {rho} and {omega} radiative decays, where the effects of a low mass scalar resonance {sigma} (500) should manifest. The recently reported data on {rho} {yields} {pi}{sup 0} {pi}{sup 0} y seem to require the contribution of a low mass and moderately narrow {sigma} (500). The properties of this controversial state could be fixed by improving the accuracy of these measurements. Data on {omega} {yields} {pi}{sup 0} {pi}{sup 0} y can also be accommodated in the framework, but are much less sensitive to the {sigma} (500) properties.

  8. Quality and Competitiveness: A Lean Six Sigma Approach

    Directory of Open Access Journals (Sweden)

    Irina-Virginia Drăgulănescu

    2015-11-01

    Full Text Available Originally developed to improve the quality and production efficiency, Lean Six Sigma is now widely adopted in other non-manufacturing sectors such as financial, trade, services, etc. The methodology known as Lean Six Sigma combines the Six Sigma techniques, ‒ which allow companies to reduce manufacturing defects ‒ and the Lean Manufacturing principles, ‒ which help companies benefit from faster processing for lower costs and with superior quality. As a result of the research, the authors observed that, despite growing popularity and impressive outcomes obtained by some companies, the Lean Six Sigma model does not always offer the expected results. However, the research has shown that the analysed company, operating in the field of courier services has managed to boost productivity and competitiveness by implementing measures that generated added value.

  9. Establishing a Lean Six Sigma Program in Higher Education

    KAUST Repository

    Svensson, Carsten

    2013-09-12

    Purpose: The objective of this paper is a contribution to the body of Lean Six Sigma knowledge within the vertical of higher education institutions. The paper will review the initial phase of an implementation and highlight future challenges. Approach: The observations presented in this paper, originates from rolling out a large lean six sigma implementation at a newly established university. The paper is supported with secondary data from literature. Findings: The paper will discuss the challenges of applying the lean six sigma method in a complex transactional environment. Research limitations: This paper is based on an empirical study of a single instance and authors’ experiences as practitioners. Originality: This paper is the first description of what is believed to be one of the largest implementations of Lean Six Sigma in higher education.

  10. Binding of Quarks and the $\\pi N$ $\\sigma$-term

    CERN Document Server

    Glozman, L Ya

    1996-01-01

    It is shown that the binding effect that is associated with the short range part of the Goldstone boson exchange interaction between constituent quarks provides a good description of the $\\pi N$ $\\sigma$-term.

  11. The Six Sigma initiative at Mount Sinai Medical Center.

    Science.gov (United States)

    Chassin, Robert

    2008-01-01

    Lean Six Sigma, in various forms, has been used widely in many Fortune 500 companies. Motorola, General Electric, Sony, American Express, and Bechtel all use Six Sigma to improve quality and performance. While the impact of this methodology has been documented extensively by the press in manufacturing and transactional settings, less evidence is available regarding its utility in health care environments. Mount Sinai Medical Center initiated a Six Sigma program in 2000 to determine its applicability and value in a large academic medical center. This article discusses Mount Sinai Medical Center's experience adapting this methodology to improve both patient care and business processes and outcomes. We present an overview of Six Sigma, and offer examples of projects undertaken using this data-driven approach to performance improvement. Lastly, the article provides insights and lessons learned regarding this organization-wide experience.

  12. POLARIMETRIC OBSERVATIONS OF {sigma} ORIONIS E

    Energy Technology Data Exchange (ETDEWEB)

    Carciofi, A. C.; Faes, D. M. [Instituto de Astronomia, Geofisica e Ciencias Atmosfericas, Universidade de Sao Paulo, Rua do Matao 1226, Cidade Universitaria, 05508-900 Sao Paulo, SP (Brazil); Townsend, R. H. D. [Department of Astronomy, University of Wisconsin-Madison, Sterling Hall, 475 N. Charter Street, Madison, WI 53706 (United States); Bjorkman, J. E., E-mail: carciofi@usp.br [Ritter Observatory, Department of Physics and Astronomy, University of Toledo, Toledo, OH 43606 (United States)

    2013-03-20

    Some massive stars possess strong magnetic fields that confine plasma in the circumstellar environment. These magnetospheres have been studied spectroscopically, photometrically, and, more recently, interferometrically. Here we report on the first firm detection of a magnetosphere in continuum linear polarization, as a result of monitoring {sigma} Ori E at the Pico dos Dias Observatory. The non-zero intrinsic polarization indicates an asymmetric structure whose minor elongation axis is oriented 150. Degree-Sign 0 east of the celestial north. A modulation of the polarization was observed with a period of half of the rotation period, which supports the theoretical prediction of the presence of two diametrally opposed, corotating blobs of gas. A phase lag of -0.085 was detected between the polarization minimum and the primary minimum of the light curve, suggestive of a complex shape of the plasma clouds. We present a preliminary analysis of the data with the Rigidly Rotating Magnetosphere model, which could not reproduce simultaneously the photometric and polarimetric data. A toy model comprising two spherical corotating blobs joined by a thin disk proved more successful in reproducing the polarization modulation. With this model we were able to determine that the total scattering mass of the thin disk is similar to the mass of the blobs (2M{sub b}/M{sub d} = 1.2) and that the blobs are rotating counterclockwise on the plane of the sky. This result shows that polarimetry can provide a diagnostic of the geometry of clouds, which will serve as an important constraint for improving the Rigidly Rotating Magnetosphere model.

  13. What is the role of the meson cloud in the $\\Sigma^{*0} \\to \\gamma \\Lambda$ and $\\Sigma^\\ast \\to \\gamma \\Sigma$ decays?

    CERN Document Server

    Ramalho, G

    2013-01-01

    We study the effect of the meson cloud dressing in the octet baryon to decuplet baryon electromagnetic transitions. Combining the valence quark contributions from the covariant spectator quark model with those of the meson cloud estimated based on the flavor SU(3) cloudy bag model, we calculate the transition magnetic form factors at $Q^2=0$ ($Q^2=-q^2$ and $q$ the four-momentum transfer), and also the decuplet baryon electromagnetic decay widths. The result for the $\\gamma^\\ast \\Lambda \\to \\Sigma^{\\ast 0}$ decay width is in complete agreement with the data, while that for the $\\gamma^\\ast \\Sigma^+ \\to \\Sigma^{\\ast +}$ is underestimated the data by 1.4 standard deviations. This achievement may be regarded as a significant advance in the present theoretical situation.

  14. A Comment on the Renormalization of the Nonlinear Sigma Model

    CERN Document Server

    Bettinelli, D; Quadri, A; Bettinelli, Daniele; Ferrari, Ruggero; Quadri, Andrea

    2007-01-01

    We consider the recently proposed renormalization procedure for the nonlinear sigma model, consisting in the recursive subtraction of the divergences in a symmetric fashion. We compare this subtraction with the conventional procedure in power counting renormalizable (PCR) theories. We argue that symmetric subtraction in the nonlinear sigma model does not follow the lore by which nonrenormalizable theories require an infinite number of parameter fixings. Our conclusion is that only two parameters can be consistently used as physical constants.

  15. N=2 supersymmetric sigma-models in AdS

    CERN Document Server

    Butter, Daniel

    2011-01-01

    We construct the most general N=2 supersymmetric nonlinear sigma-model in four-dimensional anti-de Sitter (AdS) space in terms of N=1 chiral superfields. The target space is shown to be a non-compact hyperkahler manifold restricted to possess a special Killing vector field. A remarkable property of the sigma-model constructed is that the algebra of OSp(2|4) transformations is closed off the mass shell.

  16. Automatisierte VHDL-Code-Generierung eines Delta-Sigma Modulators

    Directory of Open Access Journals (Sweden)

    R. Spilka

    2006-01-01

    Full Text Available Im vorliegenden Beitrag wird eine automatische Generierung des VHDL-Codes eines Delta-Sigma Modulators präsentiert. Die Koeffizientenmultiplikation wird hierbei durch Bit-Serielle-Addition durchgeführt. Mit Hilfe zweier neuer Matlab Funktionen wird der Systementwurf durch die bekannte Delta-Sigma Toolbox von R. Schreier erweitert und direkt synthesefähiger VHDL Code erzeugt.

  17. Improved Nucleon Properties in the Extended Quark Sigma Model

    CERN Document Server

    Abu-Shady, M

    2013-01-01

    The quark sigma model describes the quarks interacting via exchange the pions and sigma meson fields. A new version of mesonic potential is suggested in the frame of some aspects of the quantum chromodynamics (QCD). The field equations have been solved in the mean-field approximation for the hedgehog baryon state. The obtained results are compared with previous works and other models. We conclude that the suggested mesonic potential successfully calculates nucleon properties.

  18. Measurement of $R =\\sigma_{L} /\\sigma_{T}$ in deep-inelastic scattering on nuclei

    CERN Document Server

    Airapetian, A; Amarian, M; Ammosov, V V; Aschenauer, E C; Avakian, R; Avetisian, A; Avetisian, E; Bailey, P; Baturin, V; Baumgarten, C; Beckmann, M; Belostotskii, S; Blok, H P; Böttcher, Helmut B; Borisov, A; Bouhali, O; Bouwhuis, M; Brack, J; Brauksiepe, S; Brüll, A; Brunn, I; Capitani, G P; Chiang Huan Ching; Ciullo, G; Court, G R; Dalpiaz, P F; De Leo, R; De Nardo, L; De Sanctis, E; Devitsin, E G; De Witt-Huberts, P K A; Di Nezza, P; Düren, M; Ehrenfried, M; Elalaoui-Moulay, A; Elbakian, G M; Ellinghaus, F; Elschenbroich, U; Ely, J; Fabbri, R; Fantoni, A; Feshchenko, A; Felawka, L; Fischer, H; Fox, B; Franz, J; Frullani, S; Gärber, Y; Gapienko, G S; Gapienko, V A; Garibaldi, F; Garutti, E; Gavrilov, G E; Gharibian, V; Graw, G; Grebenyuk, O; Green, P W; Greeniaus, L G; Gute, A; Haeberli, W; Hafidi, K; Hartig, M; Hasch, D; Heesbeen, D; Heinsius, F H; Henoch, M; Hertenberger, R; Hesselink, W H A; Holler, Y; Hommez, B; Yarygin, G; Izotov, A; Jackson, H E; Jgoun, A; Kaiser, R; Kinney, E R; Kiselev, A; Kitching, P; Königsmann, K C; Kolster, H; Kopytine, M L; Korotkov, V A; Kotik, E; Kozlov, V; Krauss, B; Krivokhizhin, V G; Lagamba, L; Lapikas, L; Laziev, A; Lenisa, P; Liebing, P; Lindemann, T; Lorenzon, W; Makins, N C R; Marukian, G; Masoli, F; Menden, F; Mexner, V; Meyners, N; Miklukho, O; Miller, C A; Muccifora, V; Nagaitsev, A P; Nappi, E; Naryshkin, Yu; Nass, A; Negodaeva, K; Nowak, Wolf-Dieter; Oganessyan, K; Ohsuga, H; Orlandi, G; Podyachev, S P; Potashov, S Yu; Potterveld, D H; Raithel, M; Reggiani, D; Reimer, P; Reischl, A; Reolon, A R; Rith, K; Rosner, G; Rostomyan, A; Ryckbosch, D; Sakemi, Y; Sanjiev, I; Sato, F; Savin, I; Scarlett, C; Schäfer, A; Schill, C; Schnell, G; Schüler, K P; Schwind, A; Seibert, J; Seitz, B; Shanidze, R G; Shibata, T A; Shutov, V B; Simani, M C; Sinram, K; Stancari, M D; Statera, M; Steffens, E; Steijger, J J M; Stewart, J; Stösslein, U; Suetsugu, K; Tanaka, H; Taroian, S P; Terkulov, A R; Tessarin, S; Thomas, E; Tkabladze, A V; Tytgat, M; Urciuoli, G M; van der Steenhoven, G; Van de Vyver, R; Vetterli, Martin C; Vikhrov, V V; Vincter, M G; Visser, J; Volmer, J; Weiskopf, C; Wendland, J; Wilbert, J; Wise, T; Yen, S; Yoneyama, S; Zihlmann, B; Zohrabyan, H G

    2002-01-01

    Cross section ratios for deep-inelastic scattering from $^3$He, $^{14}$N and $^{84}$Kr with respect to $^2$H have been measured by the HERMES collaboration at DESY using a 27.5 GeV positron beam. The data cover a range in the Bjorken scaling variable $x$ between 0.010 and 0.65, the negative squared four-momentum transfer $Q^2$ varies from 0.5 to 15 GeV$^2$, while at small values of $x$ and $Q^2$, the virtual photon polarisation parameter $\\epsilon$ extends to lower values than previous measurements. From the dependence of the data on $\\epsilon$, values for $R_A/R_D$ with $R$ the ratio $\\sigma_L / \\sigma_T$ of longitudinal to transverse DIS cross sections have been derived and found to be consistent with unity. %The data are compared to measurements performed by NMC, E665, and SLAC %on $^4$He and $^{12}$C, and are found to be different for %$x <$ 0.06 and $Q^2 <$ 1.5 GeV$^2$.

  19. A lean Six Sigma team increases hand hygiene compliance and reduces hospital-acquired MRSA infections by 51%.

    Science.gov (United States)

    Carboneau, Clark; Benge, Eddie; Jaco, Mary T; Robinson, Mary

    2010-01-01

    A low hand hygiene compliance rate by healthcare workers increases hospital-acquired infections to patients. At Presbyterian Healthcare Services in Albuquerque, New Mexico a Lean Six Sigma team identified the reasons for noncompliance were multifaceted. The team followed the DMAIC process and completed the methodology in 12 months. They implemented multiple solutions in the three areas: Education, Culture, and Environment. Based on methicillin-resistant Staphylococcus aureus (MRSA) mortality research the team's results included an estimated 2.5 lives saved by reducing MRSA infections by 51%. Subsequently this 51% decrease in MRSA saved the hospital US$276,500. For those readers tasked with increasing hand hygiene compliance this article will provide the knowledge and insight needed to overcome multifaceted barriers to noncompliance.

  20. Six Sigma Project Selection Using Fuzzy TOPSIS Decision Making Approach

    Directory of Open Access Journals (Sweden)

    Rajeev Rathi

    2015-05-01

    Full Text Available Six Sigma is considered as a logical business strategy that attempts to identify and eliminate the defects or failures for improving the quality of product and processes. A decision on project selection in Six Sigma is always very critical; it plays a key role in successful implementation of Six Sigma. Selection of a right Six Sigma project is essentially important for an automotive company because it greatly influences the manufacturing costs. This paper discusses an approach for right Six Sigma project selection at an automotive industry using fuzzy logic based TOPSIS method. The fuzzy TOPSIS is a well recognized tool to undertake the fuzziness of the data involved in choosing the right preferences. In this context, evaluation criteria have been designed for selection of best alternative. The weights of evaluation criteria are calculated by using the MDL (modified digital logic method and final ranking is calculated through priority index obtained by using fuzzy TOPSIS method. In the selected case study, this approach has rightly helped to identify the right project for implementing Six Sigma for achieving improvement in productivity.

  1. Lean sigma--will it work for healthcare?

    Science.gov (United States)

    Bahensky, James A; Roe, Janet; Bolton, Romy

    2005-01-01

    The manufacturing industry has been using Lean Sigma for years in pursuit of continuous improvement to obtain a competitive advantage. The objectives of these efforts are to use the Lean techniques for reducing cycle times and the Six Sigma concepts for reducing product defects. The Iowa Business Council with several advocates worked with the University of Iowa Hospital and Clinics (UIHC) and two other Iowa hospitals to determine whether Lean Sigma is adaptable in healthcare. A team of 15 people at UIHC used the Kaizen Breakthrough Methodology over a five-day period in an aggressive identification and elimination of non-value added activities in Radiology CT scanning. The results exceeded the initial project objectives and indicated that Lean Sigma is applicable in healthcare. Overall, the Lean Sigma project increased revenue by approximately $750,000 per year. The Kaizen process proved to be successful and interesting. Within three days, the team installed new work flow processes. This implementation-oriented approach is what differentiates Lean Sigma from other quality improvement processes.

  2. Subneurotoxic copper(II)-induced NF-κB-dependent microglial activation is associated with mitochondrial ROS

    Energy Technology Data Exchange (ETDEWEB)

    Hu, Zhuqin; Yu, Fengxiang; Gong, Ping; Qiu, Yu; Zhou, Wei; Cui, Yongyao; Li, Juan, E-mail: lijuanpharm@gmail.com; Chen, Hongzhuan, E-mail: yaoli@shsmu.edu.cn

    2014-04-15

    Microglia-mediated neuroinflammation and the associated neuronal damage play critical roles in the pathogenesis of neurodegenerative disorders. Evidence shows an elevated concentration of extracellular copper(II) in the brains of these disorders, which may contribute to neuronal death through direct neurotoxicity. Here we explored whether extracellular copper(II) triggers microglial activation. Primary rat microglia and murine microglial cell line BV-2 cells were cultured and treated with copper(II). The content of tumor necrosis factor-α (TNF-α) and nitric oxide in the medium was determined. Extracellular hydrogen peroxide was quantified by a fluorometric assay with Amplex Red. Mitochondrial superoxide was measured by MitoSOX oxidation. At subneurotoxic concentrations, copper(II) treatment induced a dose- and time-dependent release of TNF-α and nitric oxide from microglial cells, and caused an indirect, microglia-mediated neurotoxicity that was blocked by inhibition of TNF-α and nitric oxide production. Copper(II)-initiated microglial activation was accompanied with reduced IkB-α expression as well as phosphorylation and translocation of nuclear factor-κB (NF-κB) p65 and was blocked by NF-κB inhibitors (BAY11-7082 and SC-514). Moreover, copper(II) treatment evoked a rapid release of hydrogen peroxide from microglial cells, an effect that was not affected by NADPH oxidase inhibitors. N-acetyl-cysteine, a scavenger of reactive oxygen species (ROS), abrogated copper(II)-elicited microglial release of TNF-α and nitric oxide and subsequent neurotoxicity. Importantly, mitochondrial production of superoxide, paralleled to extracellular release of hydrogen peroxide, was induced after copper(II) stimulation. Our findings suggest that extracellular copper(II) at subneurotoxic concentrations could trigger NF-κB-dependent microglial activation and subsequent neurotoxicity. NADPH oxidase-independent, mitochondria-derived ROS may be involved in this activation

  3. Observation of $\\eta_{c}$ decay into $\\Sigma^{+}\\bar{\\Sigma}^{-}$ and $\\Xi^{-}\\bar{\\Xi}^{+}$ final states

    CERN Document Server

    Ablikim, M; Albayrak, O; Ambrose, D J; An, F F; An, Q; Bai, J Z; Ban, Y; Becker, J; Bennett, J V; Bertani, M; Bian, J M; Boger, E; Bondarenko, O; Boyko, I; Briere, R A; Bytev, V; Cai, X; Cakir, O; Calcaterra, A; Cao, G F; Cetin, S A; Chang, J F; Chelkov, G; Chen, G; Chen, H S; Chen, J C; Chen, M L; Chen, S J; Chen, X; Chen, Y B; Cheng, H P; Chu, Y P; Coccetti, F; Cronin-Hennessy, D; Dai, H L; Dai, J P; Dedovich, D; Deng, Z Y; Denig, A; Denysenko, I; Destefanis, M; Ding, W M; Ding, Y; Dong, L Y; Dong, M Y; Du, S X; Fang, J; Fang, S S; Fava, L; Feldbauer, F; Feng, C Q; Ferroli, R B; Fu, C D; Fu, J L; Gao, Y; Geng, C; Goetzen, K; Gong, W X; Gradl, W; Greco, M; Gu, M H; Gu, Y T; Guan, Y H; Guo, A Q; Guo, L B; Guo, Y P; Han, Y L; Harris, F A; He, K L; He, M; He, Z Y; Held, T; Heng, Y K; Hou, Z L; Hu, H M; Hu, J F; Hu, T; Huang, G M; Huang, G S; Huang, J S; Huang, X T; Huang, Y P; Hussain, T; Ji, C S; Ji, Q; Ji, Q P; Ji, X B; Ji, X L; Jiang, L L; Jiang, X S; Jiao, J B; Jiao, Z; Jin, D P; Jin, S; Jing, F F; Kalantar-Nayestanaki, N; Kavatsyuk, M; Kornicer, M; Kuehn, W; Lai, W; Lange, J S; Li, C H; Li, Cheng; Li, Cui; Li, D M; Li, F; Li, G; Li, H B; Li, J C; Li, K; Li, Lei; Li, Q J; Li, S L; Li, W D; Li, W G; Li, X L; Li, X N; Li, X Q; Li, X R; Li, Z B; Liang, H; Liang, Y F; Liang, Y T; Liao, G R; Liao, X T; Liu, B J; Liu, C L; Liu, C X; Liu, C Y; Liu, F H; Liu, Fang; Liu, Feng; Liu, H; Liu, H H; Liu, H M; Liu, H W; Liu, J P; Liu, K Y; Liu, Kai; Liu, P L; Liu, Q; Liu, S B; Liu, X; Liu, Y B; Liu, Z A; Liu, Zhiqiang; Liu, Zhiqing; Loehner, H; Lu, G R; Lu, H J; Lu, J G; Lu, Q W; Lu, X R; Lu, Y P; Luo, C L; Luo, M X; Luo, T; Luo, X L; Lv, M; Ma, C L; Ma, F C; Ma, H L; Ma, Q M; Ma, S; Ma, T; Ma, X Y; Ma, Y; Maas, F E; Maggiora, M; Malik, Q A; Mao, Y J; Mao, Z P; Messchendorp, J G; Min, J; Min, T J; Mitchell, R E; Mo, X H; Morales, C Morales; Motzko, C; Muchnoi, N Yu; Muramatsu, H; Nefedov, Y; Nicholson, C; Nikolaev, I B; Ning, Z; Olsen, S L; Ouyang, Q; Pacetti, S; Park, J W; Pelizaeus, M; Peng, H P; Peters, K; Ping, J L; Ping, R G; Poling, R; Prencipe, E; Qi, M; Qian, S; Qiao, C F; Qin, X S; Qin, Y; Qin, Z H; Qiu, J F; Rashid, K H; Rong, G; Ruan, X D; Sarantsev, A; Schaefer, B D; Schulze, J; Shao, M; Shen, C P; Shen, X Y; Sheng, H Y; Shepherd, M R; Song, X Y; Spataro, S; Spruck, B; Sun, D H; Sun, G X; Sun, J F; Sun, S S; Sun, Y J; Sun, Y Z; Sun, Z J; Sun, Z T; Tang, C J; Tang, X; Tapan, I; Thorndike, E H; Toth, D; Ullrich, M; Varner, G S; Wang, B; Wang, B Q; Wang, D; Wang, D Y; Wang, K; Wang, L L; Wang, L S; Wang, M; Wang, P; Wang, P L; Wang, Q; Wang, Q J; Wang, S G; Wang, X L; Wang, Y D; Wang, Y F; Wang, Y Q; Wang, Z; Wang, Z G; Wang, Z Y; Wei, D H; Wei, J B; Weidenkaff, P; Wen, Q G; Wen, S P; Werner, M; Wiedner, U; Wu, L H; Wu, N; Wu, S X; Wu, W; Wu, Z; Xia, L G; Xiao, Z J; Xie, Y G; Xiu, Q L; Xu, G F; Xu, G M; Xu, H; Xu, Q J; Xu, X P; Xu, Z R; Xue, F; Xue, Z; Yan, L; Yan, W B; Yan, Y H; Yang, H X; Yang, Y; Yang, Y X; Ye, H; Ye, M; Ye, M H; Yu, B X; Yu, C X; Yu, H W; Yu, J S; Yu, S P; Yuan, C Z; Yuan, Y; Zafar, A A; Zallo, A; Zeng, Y; Zhang, B X; Zhang, B Y; Zhang, C; Zhang, C C; Zhang, D H; Zhang, H H; Zhang, H Y; Zhang, J Q; Zhang, J W; Zhang, J Y; Zhang, J Z; Zhang, S H; Zhang, X J; Zhang, X Y; Zhang, Y; Zhang, Y H; Zhang, Y S; Zhang, Z P; Zhang, Z Y; Zhao, G; Zhao, H S; Zhao, J W; Zhao, K X; Zhao, Lei; Zhao, Ling; Zhao, M G; Zhao, Q; Zhao, Q Z; Zhao, S J; Zhao, T C; Zhao, X H; Zhao, Y B; Zhao, Z G; Zhemchugov, A; Zheng, B; Zheng, J P; Zheng, Y H; Zhong, B; Zhong, J; Zhong, Z; Zhou, L; Zhou, X K; Zhou, X R; Zhu, C; Zhu, K; Zhu, K J; Zhu, S H; Zhu, X L; Zhu, Y C; Zhu, Y M; Zhu, Y S; Zhu, Z A; Zhuang, J; Zou, B S; Zou, J H

    2012-01-01

    Using a data sample of $2.25\\times10^{8}$ $J/\\psi$ events collected with the BESIII detector, we present the first observation of the decays of $\\eta_{c}$ mesons to $\\Sigma^{+}\\bar{\\Sigma}^{-}$ and $\\Xi^{-}\\bar{\\Xi}^{+}$. The branching fractions are measured to be $(2.11\\pm0.28_{\\rm stat.}\\pm0.18_{\\rm syst.}\\pm0.50_{\\rm PDG})\\times10^{-3}$ and $(0.89\\pm0.16_{\\rm stat.}\\pm0.08_{\\rm syst.}\\pm0.21_{\\rm PDG})\\times10^{-3}$ for $\\eta_{c} \\to \\Sigma^{+}\\bar{\\Sigma}^{-}$ and $\\Xi^{-}\\bar{\\Xi}^{+}$, respectively. These branching fractions provide important information on the helicity selection rule in charmonium-decay processes.

  4. Exfoliative Toxins of Staphylococcus aureus

    Directory of Open Access Journals (Sweden)

    Michal Bukowski

    2010-05-01

    Full Text Available Staphylococcus aureus is an important pathogen of humans and livestock. It causes a diverse array of diseases, ranging from relatively harmless localized skin infections to life-threatening systemic conditions. Among multiple virulence factors, staphylococci secrete several exotoxins directly associated with particular disease symptoms. These include toxic shock syndrome toxin 1 (TSST-1, enterotoxins, and exfoliative toxins (ETs. The latter are particularly interesting as the sole agents responsible for staphylococcal scalded skin syndrome (SSSS, a disease predominantly affecting infants and characterized by the loss of superficial skin layers, dehydration, and secondary infections. The molecular basis of the clinical symptoms of SSSS is well understood. ETs are serine proteases with high substrate specificity, which selectively recognize and hydrolyze desmosomal proteins in the skin. The fascinating road leading to the discovery of ETs as the agents responsible for SSSS and the characterization of the molecular mechanism of their action, including recent advances in the field, are reviewed in this article.

  5. Genome-wide prediction and validation of sigma70 promoters in Lactobacillus plantarum WCFS1

    NARCIS (Netherlands)

    Todt, T.J.; Wels, M.; Bongers, R.S.; Siezen, R.S.; Hijum, S.A. van; Kleerebezem, M.

    2012-01-01

    BACKGROUND: In prokaryotes, sigma factors are essential for directing the transcription machinery towards promoters. Various sigma factors have been described that recognize, and bind to specific DNA sequence motifs in promoter sequences. The canonical sigma factor sigma(70) is commonly involved in

  6. Potential applications for sigma receptor ligands in cancer diagnosis and therapy

    NARCIS (Netherlands)

    van Waarde, Aren; Rybczynska, Anna A.; Kuzhuppilly Ramakrishnan, Nisha; Ishiwata, Kiichi; Elsinga, Philip H.; Dierckx, Rudi A. J. O.

    2015-01-01

    Sigma receptors (sigma-1 and sigma-2) represent two independent classes of proteins. Their endogenous ligands may include the hallucinogen N,N-dimethyltryptamine (DMT) and sphingolipid-derived amines which interact with sigma-1 receptors, besides steroid hormones (e.g., progesterone) which bind to b

  7. The flagellar-specific transcription factor, sigma28, is the Type III secretion chaperone for the flagellar-specific anti-sigma28 factor FlgM.

    Science.gov (United States)

    Aldridge, Phillip D; Karlinsey, Joyce E; Aldridge, Christine; Birchall, Christopher; Thompson, Danielle; Yagasaki, Jin; Hughes, Kelly T

    2006-08-15

    The sigma(28) protein is a member of the bacterial sigma(70)-family of transcription factors that directs RNA polymerase to flagellar late (class 3) promoters. The sigma(28) protein is regulated in response to flagellar assembly by the anti-sigma(28) factor FlgM. FlgM inhibits sigma(28)-dependent transcription of genes whose products are needed late in assembly until the flagellar basal motor structure, the hook-basal body (HBB), is constructed. A second function for the sigma(28) transcription factor has been discovered: sigma(28) facilitates the secretion of FlgM through the HBB, acting as the FlgM Type III secretion chaperone. Transcription-specific mutants in sigma(28) were isolated that remained competent for FlgM-facilitated secretion separating the transcription and secretion-facilitation activities of sigma (28). Conversely, we also describe the isolation of mutants in sigma(28) that are specific for FlgM-facilitated secretion. The data demonstrate that sigma(28) is the Type III secretion chaperone for its own anti-sigma factor FlgM. Thus, a novel role for a sigma(70)-family transcription factor is described.

  8. 21 CFR 866.3700 - Staphylococcus aureus serological reagents.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Staphylococcus aureus serological reagents. 866... Staphylococcus aureus serological reagents. (a) Identification. Staphylococcus aureus serological reagents are... epidemiological information on these diseases. Certain strains of Staphylococcus aureus produce an...

  9. Inhibitory effect of the antidepressant imipramine on NF-κB-dependent CXCL1 expression in TNFα-exposed astrocytes.

    Science.gov (United States)

    Lee, Young Han; Kim, Se Hyun; Kim, Yeni; Lim, Yoongho; Ha, Kyooseob; Shin, Soon Young

    2012-04-01

    Neuroinflammation is associated with the pathophysiology of various neurodegenerative diseases. Emerging evidence indicates that imipramine, a tricyclic antidepressant commonly used in depressive disorders, exhibits neuroprotective activity partly through anti-inflammatory effects. However, the molecular mechanisms underlying imipramine-mediated anti-inflammatory response are poorly understood. In this study, rat primary cultured astrocytes were used to elucidate the effect of the imipramine on TNFα-induced inflammatory responses. The results clearly demonstrated that imipramine reduced TNFα-induced CXCL1 expression through suppression of NF-κB-dependent CXCL1 promoter activity in primary astrocytes. In addition, we found that imipramine suppressed TNFα-induced phosphorylation of inhibitor of κBα (IκBα) and p65/RelA nuclear factor-κB (NF-κB), as well as the nuclear translocation of p65/RelA in primary cultured astrocytes. Chemotaxis assay demonstrated that astrocyte-derived CXCL1 contributed to migration of BV2 microglial cells toward astrocytes. This response was significantly blocked by treatment of astrocytes with imipramine or NF-κB inhibitor BAY11-7082. This study indicates that the antidepressant imipramine inhibits TNFα-induced CXCL1 expression via down-regulation of NF-κB signaling pathway in astrocytes and suggests that imipramine has a potential as an anti-inflammatory drug.

  10. Chromatin remodeling protein SMAR1 regulates NF-κB dependent Interleukin-8 transcription in breast cancer.

    Science.gov (United States)

    Malonia, Sunil K; Yadav, Bhawna; Sinha, Surajit; Lazennec, Gwendel; Chattopadhyay, Samit

    2014-10-01

    Interleukin-8 (IL-8) is a pleiotropic chemokine involved in metastasis and angiogenesis of breast tumors. The expression of IL-8 is deregulated in metastatic breast carcinomas owing to aberrant NF-κB activity, which is known to positively regulate IL-8 transcription. Earlier, we have shown that tumor suppressor SMAR1 suppresses NF-κB transcriptional activity by modulating IκBα function. Here, we show that NF-κB target gene IL-8, is a direct transcriptional target of SMAR1. Using chromatin immunoprecipitation and reporter assays, we demonstrate that SMAR1 binds to IL-8 promoter MAR (matrix attachment region) and recruits HDAC1 dependent co-repressor complex. Further, we also show that SMAR1 antagonizes p300-mediated acetylation of RelA/p65, a post-translational modification indispensable for IL-8 transactivation. Thus, we decipher a new role of SMAR1 in NF-κB dependent transcriptional regulation of pro-angiogenic chemokine IL-8.

  11. MiR-155 induction by microbes/microbial ligands requires NF-kB-dependent de novo protein synthesis

    Directory of Open Access Journals (Sweden)

    Susheela eTridandapani

    2012-06-01

    Full Text Available MiR-155 regulates numerous aspects of innate and adaptive immune function. This miR is induced in response to toll-like receptor ligands, cytokines, and microbial infection. We have previously shown that miR-155 is induced in monocytes/macrophages infected with Francisella tularensis and suppresses expression of the inositol phosphatase SHIP to enhance activation of the PI3K/Akt pathway, which in turn promotes favorable responses for the host. Here we examined how miR-155 expression is regulated during infection. First, our data demonstrate that miR-155 can be induced through soluble factors of bacterial origin and not the host. Second, miR-155 induction is not a direct effect of infection and it requires NF-κB signaling to up-regulate fos/jun transcription factors. Finally, we demonstrate that the requirement for NF-κB-dependent de novo protein synthesis is globally shared by microbial ligands and live bacteria. This study provides new insight into the complex regulation of miR-155 during microbial infection.

  12. Distribution and functions of TonB-dependent transporters in marine bacteria and environments: implications for dissolved organic matter utilization.

    Directory of Open Access Journals (Sweden)

    Kai Tang

    Full Text Available BACKGROUND: Bacteria play critical roles in marine nutrient cycles by incorporating and redistributing dissolved organic matter (DOM and inorganic nutrients in the ocean. TonB-dependent transporter (TBDT proteins allow Gram-negative bacteria to take up scarce resources from nutrient-limiting environments as well as siderophores, heme, vitamin B12, and recently identified carbohydrates. Thus, the characterization of TBDT distribution and functions is essential to better understand the contribution TBDT to DOM assimilation and its consequences on nutrient cycling in the environment. METHODOLOGY/PRINCIPAL FINDINGS: This study presents the distribution of encoded known and putative TBDT proteins in the genomes of microorganisms and from the Global Ocean Survey data. Using a Lek clustering algorithm and substrate specificities, the TBDT sequences were mainly classified into the following three groups: (1 DOM transporters; (2 Siderophores/Vitamins transporters; and (3 Heme/Hemophores/Iron(heme-binding protein transporters. Diverse TBDTs were found in the genomes of oligotroph Citromicrobium bathyomarinum JL354 and Citromicrobium sp JLT1363 and were highly expressed in the stationary phase of bacterial growth. The results show that the Gammaproteobacteria and the Cytophaga-Flavobacterium-Bacteroides (CFB group bacteria accounted for the majority of the TBDT gene pool in marine surface waters. CONCLUSIONS/SIGNIFICANCE: The results of this study confirm the ecological importance of TBDTs in DOM assimilation for bacteria in marine environments owing to a wide range of substrate utilization potential in the ubiquitous Gammaproteobacteria and CFB group bacteria.

  13. Sigma-1 Receptors and Neurodegenerative Diseases: Towards a Hypothesis of Sigma-1 Receptors as Amplifiers of Neurodegeneration and Neuroprotection.

    Science.gov (United States)

    Nguyen, Linda; Lucke-Wold, Brandon P; Mookerjee, Shona; Kaushal, Nidhi; Matsumoto, Rae R

    2017-01-01

    Sigma-1 receptors are molecular chaperones that may act as pathological mediators and targets for novel therapeutic applications in neurodegenerative diseases. Accumulating evidence indicates that sigma-1 ligands can either directly or indirectly modulate multiple neurodegenerative processes, including excitotoxicity, calcium dysregulation, mitochondrial and endoplasmic reticulum dysfunction, inflammation, and astrogliosis. In addition, sigma-1 ligands may act as disease-modifying agents in the treatment for central nervous system (CNS) diseases by promoting the activity of neurotrophic factors and neural plasticity. Here, we summarize their neuroprotective and neurorestorative effects in different animal models of acute brain injury and chronic neurodegenerative diseases, and highlight their potential role in mitigating disease. Notably, current data suggest that sigma-1 receptor dysfunction worsens disease progression, whereas enhancement amplifies pre-existing functional mechanisms of neuroprotection and/or restoration to slow disease progression. Collectively, the data support a model of the sigma-1 receptor as an amplifier of intracellular signaling, and suggest future clinical applications of sigma-1 ligands as part of multi-therapy approaches to treat neurodegenerative diseases.

  14. Incorporating IPMVP and Six Sigma Strategies into Monitoring and Evaluation

    Energy Technology Data Exchange (ETDEWEB)

    Carlson, Kathleen [Verified, Inc. (United States); Mowris, Robert; Jones, Ean [Robert Mowris and Associates (United States)

    2007-07-01

    Increased emphasis on energy efficiency to reduce energy use and mitigate global warming requires rigorous evaluations based on the International Performance Measurement and Verification Protocol (IPMVP). The California Public Utilities Commission, New York State Energy Research and Development Authority (NYSERDA), the World Bank, and many state and federal agencies require adherence to IPMVP. The World Resources Inst. recommends evaluation standards such as IPMVP for the Kyoto Protocol. Increased emphasis on customer satisfaction and resource efficiency to improve profitability has motivated businesses worldwide to adopt Six Sigma strategies. Motorola, General Electric, Sony, Honda, Toyota, and many other companies have adopted Six Sigma to decrease costs and increase profitability and market share. The objectives of IPMVP and Six Sigma are similar to IEA Annex 40 which provides tools, guidelines, and recommendations for commissioning HVAC systems to optimize building energy efficiency. IPMVP provides a framework to measure, verify, and commission energy efficiency and renewable energy savings. Six Sigma provides a framework to measure and verify energy efficiency performance metrics at critical steps in the market chain (i.e., design, manufacturing, installation). Incorporating IPMVP and Six Sigma into monitoring and evaluation will help program implementers, utilities, consumers, corporations, and government agencies better understand the value of energy efficiency.This paper provides an example of how to incorporate IPMVP and Six Sigma strategies into monitoring and evaluation studies of four residential air conditioner incentive programs implemented by public utilities in California. The net realization rates for the four residential air conditioner programs are 0.53 {+-} 0.1 for kWh and 0.58 {+-} 0.04 for kW. The net realization rates are lower than anticipated due to lower baseline usage, lower ex post savings, and lower net-to-gross ratios. Findings for the

  15. Six Sigma a zlepšenie špecifickej účtovnej kontroly

    OpenAIRE

    Otčenášová, Jana

    2009-01-01

    The thesis, entitled "Six Sigma and improvement of the specific financial control" deals with the Six Sigma methodology in general in theoretical part. It defines the method, the objectives of its establishment, its history, next, theoretical part covers key aspects of Six Sigma, its principles and benefits, tools, management responsibilities for Six Sigma, the COQ in terms of Six Sigma philosophy and most important, the DMAIC methodology, which combines theoretical and empirical part of the ...

  16. Modus operandi of the bacterial RNA polymerase containing the sigma54 promoter-specificity factor.

    Science.gov (United States)

    Wigneshweraraj, Sivaramesh; Bose, Daniel; Burrows, Patricia C; Joly, Nicolas; Schumacher, Jörg; Rappas, Mathieu; Pape, Tillmann; Zhang, Xiaodong; Stockley, Peter; Severinov, Konstantin; Buck, Martin

    2008-05-01

    Bacterial sigma (sigma) factors confer gene specificity upon the RNA polymerase, the central enzyme that catalyses gene transcription. The binding of the alternative sigma factor sigma(54) confers upon the RNA polymerase special functional and regulatory properties, making it suited for control of several major adaptive responses. Here, we summarize our current understanding of the interactions the sigma(54) factor makes with the bacterial transcription machinery.

  17. Mastite com lesões sistêmicas por Staphylococus aureus subesp. aureus em coelhos

    OpenAIRE

    Traverso Sandra Davi; Cunha Leonardo da; Fernandes Joaquim César Teixeira; Loretti Alexandre Paulino; Rhoden Adriana; Wunder Jr. Elsio; Driemeier David

    2003-01-01

    Em uma criação composta por 1800 coelhos, 33% das matrizes apresentaram mastite e lesões cutâneas crostosas e purulentas. Estes animais apresentavam-se entre 10 a- 12 meses de idade e em segunda parição. Quinze coelhos afetados foram sacrificados e necropsiados. Na necropsia, além das lesões cutâneas haviam microabscessos em diversos órgãos. Das amostras coletadas isolou-se Staphylococcus aureus subesp. aureus. S. aureus subesp. aureus também foi isolado de "swab" nasal coletado do tratador e...

  18. Etudes structurales du ribosome de Staphylococcus aureus

    OpenAIRE

    Khusainov, Iskander

    2015-01-01

    The ribosome is a large cellular machinery that performs the protein synthesis in every living cell. Therefore, the ribosome is one of the major targets of naturally produced antibiotics, which can kill bacterial cells by blocking protein synthesis. However, some bacteria are resistant to these antibiotics due to small modifications of their ribosomes. Among them, Staphylococcus aureus (S. aureus) is a severe pathogen that causes numerous infections in humans. The crystal structures of comple...

  19. Topiramate protects against glutamate excitotoxicity via activating BDNF/TrkB-dependent ERK pathway in rodent hippocampal neurons.

    Science.gov (United States)

    Mao, Xiao-Yuan; Cao, Yong-Gang; Ji, Zhong; Zhou, Hong-Hao; Liu, Zhao-Qian; Sun, Hong-Li

    2015-07-01

    Topiramate (TPM) was previously found to have neuroprotection against neuronal injury in epileptic and ischemic models. However, whether TPM protects against glutamate-induced excitotoxicity in hippocampal neurons is elusive. Our present work aimed to evaluate the protective effect of TPM against glutamate toxicity in hippocampal neurons and further figure out the potential molecular mechanisms. The in vitro glutamate excitotoxic model was prepared with 125μM glutamate for 20min. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide (MTT) analysis and Hoechst 33342 staining were conducted to detect neuronal survival. The protein expressions of brain-derived neurotrophic factor (BDNF), TrkB, mitogen-activated protein kinase (MAPK) cascade (including extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK) and p38 MAPK), cyclic AMP response element binding protein (CREB), Bcl-2, Bax and β-actin were detected via Western blot assay. Our results demonstrated that TPM protected hippocampal neurons from glutamate toxicity. Meanwhile, the pretreatment of TPM for 10min significantly prevented the down-regulation of BDNF and the phosphorylation of TrkB. Furthermore, the elevation of phosphorylated EKR expression was significantly inhibited after blockade of TrkB by TrkB IgG, while no alterations of phosphorylated JNK and p38 MAPK were found in the cultured hippocampal neurons. Besides, it was also found that the enhanced phosphorylation of CREB was evidently reversed under excitotoxic conditions after treating with U0126 (the selective inhibitor of ERK). The protein level of Bcl-2 was also observed to be remarkably increased after TPM treatment. In conclusion, these findings implicate that TPM exerts neuroprotective effects against glutamate excitotoxicity in hippocampal neurons and its protection may be modulated through BDNF/TrkB-dependent ERK pathway.

  20. EWS-FLI1 inhibits TNF{alpha}-induced NF{kappa}B-dependent transcription in Ewing sarcoma cells

    Energy Technology Data Exchange (ETDEWEB)

    Lagirand-Cantaloube, Julie, E-mail: julie.cantaloube@crbm.cnrs.fr [UMR8113 CNRS, LBPA, Ecole Normale Superieure, Cachan (France); Laud, Karine, E-mail: karine.laud@curie.fr [U830 INSERM, Institut Curie, Paris (France); Institut Curie, Genetique et biologie des cancers, Paris (France); Lilienbaum, Alain, E-mail: alain.lilienbaum@univ-paris-diderot.fr [EA300 Universite Paris 7, Stress et pathologies du cytosquelette, Paris (France); Tirode, Franck, E-mail: franck.tirode@curie.fr [U830 INSERM, Institut Curie, Paris (France); Institut Curie, Genetique et biologie des cancers, Paris (France); Delattre, Olivier, E-mail: olivier.delattre@curie.fr [U830 INSERM, Institut Curie, Paris (France); Institut Curie, Genetique et biologie des cancers, Paris (France); Auclair, Christian, E-mail: auclair@lbpa.ens-cachan.fr [UMR8113 CNRS, LBPA, Ecole Normale Superieure, Cachan (France); Kryszke, Marie-Helene, E-mail: kryszke@lbpa.ens-cachan.fr [UMR8113 CNRS, LBPA, Ecole Normale Superieure, Cachan (France)

    2010-09-03

    Research highlights: {yields} EWS-FLI1 interferes with TNF-induced activation of NF{kappa}B in Ewing sarcoma cells. {yields} EWS-FLI1 knockdown in Ewing sarcoma cells increases TNF-induced NF{kappa}B binding to DNA. {yields} EWS-FLI1 reduces TNF-stimulated NF{kappa}B-dependent transcriptional activation. {yields} Constitutive NF{kappa}B activity is not affected by EWS-FLI1. {yields} EWS-FLI1 physically interacts with NF{kappa}B p65 in vivo. -- Abstract: Ewing sarcoma is primarily caused by a t(11;22) chromosomal translocation encoding the EWS-FLI1 fusion protein. To exert its oncogenic function, EWS-FLI1 acts as an aberrant transcription factor, broadly altering the gene expression profile of tumor cells. Nuclear factor-kappaB (NF{kappa}B) is a tightly regulated transcription factor controlling cell survival, proliferation and differentiation, as well as tumorigenesis. NF{kappa}B activity is very low in unstimulated Ewing sarcoma cells, but can be induced in response to tumor necrosis factor (TNF). We wondered whether NF{kappa}B activity could be modulated by EWS-FLI1 in Ewing sarcoma. Using a knockdown approach in Ewing sarcoma cells, we demonstrated that EWS-FLI1 has no influence on NF{kappa}B basal activity, but impairs TNF-induced NF{kappa}B-driven transcription, at least in part through inhibition of NF{kappa}B binding to DNA. We detected an in vivo physical interaction between the fusion protein and NF{kappa}B p65, which could mediate these effects. Our findings suggest that, besides directly controlling the activity of its primary target promoters, EWS-FLI1 can also indirectly influence gene expression in tumor cells by modulating the activity of key transcription factors such as NF{kappa}B.

  1. Plant carbohydrate scavenging through tonB-dependent receptors: a feature shared by phytopathogenic and aquatic bacteria.

    Science.gov (United States)

    Blanvillain, Servane; Meyer, Damien; Boulanger, Alice; Lautier, Martine; Guynet, Catherine; Denancé, Nicolas; Vasse, Jacques; Lauber, Emmanuelle; Arlat, Matthieu

    2007-02-21

    TonB-dependent receptors (TBDRs) are outer membrane proteins mainly known for the active transport of iron siderophore complexes in Gram-negative bacteria. Analysis of the genome of the phytopathogenic bacterium Xanthomonas campestris pv. campestris (Xcc), predicts 72 TBDRs. Such an overrepresentation is common in Xanthomonas species but is limited to only a small number of bacteria. Here, we show that one Xcc TBDR transports sucrose with a very high affinity, suggesting that it might be a sucrose scavenger. This TBDR acts with an inner membrane transporter, an amylosucrase and a regulator to utilize sucrose, thus defining a new type of carbohydrate utilization locus, named CUT locus, involving a TBDR for the transport of substrate across the outer membrane. This sucrose CUT locus is required for full pathogenicity on Arabidopsis, showing its importance for the adaptation to host plants. A systematic analysis of Xcc TBDR genes and a genome context survey suggested that several Xcc TBDRs belong to other CUT loci involved in the utilization of various plant carbohydrates. Interestingly, several Xcc TBDRs and CUT loci are conserved in aquatic bacteria such as Caulobacter crescentus, Colwellia psychrerythraea, Saccharophagus degradans, Shewanella spp., Sphingomonas spp. or Pseudoalteromonas spp., which share the ability to degrade a wide variety of complex carbohydrates and display TBDR overrepresentation. We therefore propose that TBDR overrepresentation and the presence of CUT loci designate the ability to scavenge carbohydrates. Thus CUT loci, which seem to participate to the adaptation of phytopathogenic bacteria to their host plants, might also play a very important role in the biogeochemical cycling of plant-derived nutrients in marine environments. Moreover, the TBDRs and CUT loci identified in this study are clearly different from those characterized in the human gut symbiont Bacteroides thetaiotaomicron, which allow glycan foraging, suggesting a convergent

  2. Plant carbohydrate scavenging through tonB-dependent receptors: a feature shared by phytopathogenic and aquatic bacteria.

    Directory of Open Access Journals (Sweden)

    Servane Blanvillain

    Full Text Available TonB-dependent receptors (TBDRs are outer membrane proteins mainly known for the active transport of iron siderophore complexes in Gram-negative bacteria. Analysis of the genome of the phytopathogenic bacterium Xanthomonas campestris pv. campestris (Xcc, predicts 72 TBDRs. Such an overrepresentation is common in Xanthomonas species but is limited to only a small number of bacteria. Here, we show that one Xcc TBDR transports sucrose with a very high affinity, suggesting that it might be a sucrose scavenger. This TBDR acts with an inner membrane transporter, an amylosucrase and a regulator to utilize sucrose, thus defining a new type of carbohydrate utilization locus, named CUT locus, involving a TBDR for the transport of substrate across the outer membrane. This sucrose CUT locus is required for full pathogenicity on Arabidopsis, showing its importance for the adaptation to host plants. A systematic analysis of Xcc TBDR genes and a genome context survey suggested that several Xcc TBDRs belong to other CUT loci involved in the utilization of various plant carbohydrates. Interestingly, several Xcc TBDRs and CUT loci are conserved in aquatic bacteria such as Caulobacter crescentus, Colwellia psychrerythraea, Saccharophagus degradans, Shewanella spp., Sphingomonas spp. or Pseudoalteromonas spp., which share the ability to degrade a wide variety of complex carbohydrates and display TBDR overrepresentation. We therefore propose that TBDR overrepresentation and the presence of CUT loci designate the ability to scavenge carbohydrates. Thus CUT loci, which seem to participate to the adaptation of phytopathogenic bacteria to their host plants, might also play a very important role in the biogeochemical cycling of plant-derived nutrients in marine environments. Moreover, the TBDRs and CUT loci identified in this study are clearly different from those characterized in the human gut symbiont Bacteroides thetaiotaomicron, which allow glycan foraging

  3. APLIKASI SIX SIGMA PADA PRODUK CLEAR FILE DI PERUSAHAAN STATIONARY

    Directory of Open Access Journals (Sweden)

    Desy Emilasari

    2007-01-01

    Full Text Available This paper describes the application of the Six Sigma methods is used in order to improve quality in manufacturing company that produce stationary product. DMAIC approach is utilized to analyze and improve 'Pocket Clear File' product since this product has more variability and defects. Quality improvement also monitor the process that influenced pocket defect in Bag Making, Kami-ire, Karidome, and Pocket after Karidome Inspections section. Determining of Six Sigma project is based in process and defect type in each section. FMEA also gave the recommendation for quality improvement we need to evaluate the final result of the improvement since some of them were not working properly. Abstract in Bahasa Indonesia : Paper ini menggambarkan bagaimana aplikasi metode Six Sigma digunakan untuk melakukan perbaikan kualitas pada perusahaan manufaktur yang memproduksi produk stationary. Pendekatan DMAIC dipakai untuk menganalisa dan melakukan perbaikan produk 'Pocket Clear File' karena tingginya variabilitas dan cacat dibanding produk lain. Perbaikan kualitas juga memperhatikan proses yang mempengaruhi terjadinya cacat pocket pada section Bag Making, Kami-ire, Karidome, dan Pocket after Karidome Inspection. Penentuan proyek Six Sigma didasarkan atas proses dan jenis cacat pada setiap section. Pendekatan FMEA mampu memberi rekomendasi perbaikan kualitas. Evaluasi dari hasil perbaikan penting untuk dilakukan karena beberapa implementasi perbaikan kualitas tidak berjalan sesuai dengan rencana. kata kunci: six sigma, DMAIC, perusahaan stationary.

  4. Sistem Informasi Kinerja Layanan Laboratorium Medis dengan Metode Six Sigma

    Directory of Open Access Journals (Sweden)

    Anindita Kusumastuti Dewi

    2016-01-01

    Full Text Available Medical Laboratory currently holds a very important role in medicine. Evaluation of laboratory quality plays a very important to maintain accurate laboratory results. This study aims to design an information system performance based on the same perception of medical laboratory services from customers using Six Sigma methods and frameworks using ServQual questionnaire. Selection of Six Sigma itself is based on this method can measure the extent to which each process deviates from its purpose as well as to reduce the variation of each of the attributes.  Six Sigma DMAIC namely (Define, Measure, Analyze, Improve, Control preferred because the end result will not yield new products, but only improvements on existing processes. The results of this calculation will be presented in the form of a dashboard for easier management in understanding the results of the evaluation. From the system can be obtained an average value of consumer perceptions terhdap performance today is 2,883, consumer expectations on the performance of 3.3768, the gap between the perceptions and expectations of consumers is -0.4936, customer satisfaction will be the performance of the current 85.37%, the value of 423 360 DPMO and sigma value there at the 2.07664 level.   Keywords: Laboratory Performance; Six Sigma; Servqual; Dashboard

  5. Functional modules of sigma factor regulons guarantee adaptability and evolvability

    Science.gov (United States)

    Binder, Sebastian C.; Eckweiler, Denitsa; Schulz, Sebastian; Bielecka, Agata; Nicolai, Tanja; Franke, Raimo; Häussler, Susanne; Meyer-Hermann, Michael

    2016-02-01

    The focus of modern molecular biology turns from assigning functions to individual genes towards understanding the expression and regulation of complex sets of molecules. Here, we provide evidence that alternative sigma factor regulons in the pathogen Pseudomonas aeruginosa largely represent insulated functional modules which provide a critical level of biological organization involved in general adaptation and survival processes. Analysis of the operational state of the sigma factor network revealed that transcription factors functionally couple the sigma factor regulons and significantly modulate the transcription levels in the face of challenging environments. The threshold quality of newly evolved transcription factors was reached faster and more robustly in in silico testing when the structural organization of sigma factor networks was taken into account. These results indicate that the modular structures of alternative sigma factor regulons provide P. aeruginosa with a robust framework to function adequately in its environment and at the same time facilitate evolutionary change. Our data support the view that widespread modularity guarantees robustness of biological networks and is a key driver of evolvability.

  6. A Lean Six Sigma program in higher education

    KAUST Repository

    Svensson, Carsten

    2015-01-01

    Purpose The objective of this paper is to contribute to the body of Lean Six Sigma knowledge within the field of higher education institutions. The paper will review the initial phase of an implementation and highlight future challenges of applying the Lean Six Sigma method in a complex transactional environment. Design/methodology/approach The observations presented in this paper originate from rolling out a large Lean Six Sigma implementation at a recently established university. The paper is supported with secondary data from literature. Findings The implementation of Lean Six Sigma methodology at King Abdullah University of Science and Technology (KAUST) has resulted in improvements in business processes and efficiency. This has been achieved through project execution and training programs. Approximately 350 staff members have completed awareness training, 50 yellow belts and 150 green belts have been trained, and the first round of seven black belts have completed training of which two have completed certification. Research limitations/implications This paper is based on an empirical study of a single instance and the authors’ experiences as practitioners. Originality/value This paper is the first description of what is believed to be one of the largest implementations of Lean Six Sigma in higher education.

  7. The Application of Six Sigma Method in a Power Plant

    Directory of Open Access Journals (Sweden)

    Zumrut Ecevit Sati

    Full Text Available In the last decade a process improvement technique, known as Six Sigma, is implemented by many pioneers of the industry as an approach used to more productive and increase profits in all business process from production to human resources management, from finance to marketing. The companies would like to keep and improve their position in a daily changing world market while new techniques and concepts are introduced to the global markets every day and this is only possible through continuous improvements and breakthroughs. In this study, it has been presented the six sigma practice of a power plant owned by Enerjisa, a major energy company in Turkey. In order to achieve Six Sigma project targets, quality techniques and statistical techniques (hypothesis testing, design of experiment etc. are used.

  8. Yang–Baxter sigma models based on the CYBE

    Energy Technology Data Exchange (ETDEWEB)

    Matsumoto, Takuya, E-mail: takuya.matsumoto@math.nagoya-u.ac.jp [Institute for Advanced Research and Department of Mathematics, Nagoya University, Nagoya 464-8602 (Japan); Yoshida, Kentaroh, E-mail: kyoshida@gauge.scphys.kyoto-u.ac.jp [Department of Physics, Kyoto University, Kyoto 606-8502 (Japan)

    2015-04-15

    It is known that Yang–Baxter sigma models provide a systematic way to study integrable deformations of both principal chiral models and symmetric coset sigma models. In the original proposal and its subsequent development, the deformations have been characterized by classical r-matrices satisfying the modified classical Yang–Baxter equation (mCYBE). In this article, we propose the Yang–Baxter sigma models based on the classical Yang–Baxter equations (CYBE) rather than the mCYBE. This generalization enables us to utilize various kinds of solutions of the CYBE to classify integrable deformations. In particular, it is straightforward to realize partial deformations of the target space without loss of the integrability of the parent theory.

  9. Quasicomplex N=2, d=1 Supersymmetric Sigma Models

    Directory of Open Access Journals (Sweden)

    Evgeny A. Ivanov

    2013-11-01

    Full Text Available We derive and discuss a new type of N=2 supersymmetric quantum mechanical sigma models which appear when the superfield action of the (1,2,1 multiplets is modified by adding an imaginary antisymmetric tensor to the target space metric, thus completing the latter to a non-symmetric Hermitian metric. These models are not equivalent to the standard de Rham sigma models, but are related to them through a certain special similarity transformation of the supercharges. On the other hand, they can be obtained by a Hamiltonian reduction from the complex supersymmetric N=2 sigma models built on the multiplets (2,2,0 and describing the Dolbeault complex on the manifolds with proper isometries. We study in detail the extremal two-dimensional case, when the target space metric is defined solely by the antisymmetric tensor, and show that the corresponding quantum systems reveal a hidden N=4 supersymmetry.

  10. The Process to Estimate Economical Benefits of Six Sigma Projects

    Directory of Open Access Journals (Sweden)

    Jan Kosina

    2013-07-01

    Full Text Available This paper seeks to define the process for the continuous evaluation of the financial benefits during Six Sigma project life time. The financial criteria are critical success factors of a Six Sigma project. The process has been developed as part of the six sigma project monitoring in order to estimate proper allocation of the resources taking in account the expected project benefits as well as evaluationof real achievements. The evaluation of the finacial benefits based on the quality costs is not sufficient in the real life and has to be accomplished with key financial performance indicators of the business to visualize the results. The evaluation based on the savings seems to be too difficult especially for green belts. The early involvement of the finance department in the project definition as well as ongoing evaluation is key. The defined process has been applied to real business enviroment.

  11. Sliding mode control the delta-sigma modulation approach

    CERN Document Server

    Sira-Ramírez, Hebertt

    2015-01-01

    This monograph presents a novel method of sliding mode control for switch-regulated nonlinear systems. The Delta Sigma modulation approach allows one to implement a continuous control scheme using one or multiple, independent switches, thus effectively merging the available linear and nonlinear controller design techniques with sliding mode control.   Sliding Mode Control: The Delta-Sigma Modulation Approach, combines rigorous mathematical derivation of the unique features of Sliding Mode Control and Delta-Sigma modulation with numerous illustrative examples from diverse areas of engineering. In addition, engineering case studies demonstrate the applicability of the technique and the ease with which one can implement the exposed results. This book will appeal to researchers in control engineering and can be used as graduate-level textbook for a first course on sliding mode control.

  12. Carotenoid Formation by Staphylococcus aureus

    Science.gov (United States)

    Hammond, Ray K.; White, David C.

    1970-01-01

    The carotenoid pigments of Staphylococcus aureus U-71 were identified as phytoene; ζ-carotene; δ-carotene; phytofluenol; a phytofluenol-like carotenoid, rubixanthin; and three rubixanthin-like carotenoids after extraction, saponification, chromatographic separation, and determination of their absorption spectra. There was no evidence of carotenoid esters or glycoside ethers in the extract before saponification. During the aerobic growth cycle the total carotenoids increased from 45 to 1,000 nmoles per g (dry weight), with the greatest increases in the polar, hydroxylated carotenoids. During the anaerobic growth cycle, the total carotenoids increased from 20 nmoles per g (dry weight) to 80 nmoles per g (dry weight), and only traces of the polar carotenoids were formed. Light had no effect on carotenoid synthesis. About 0.14% of the mevalonate-2-14C added to the culture was incorporated into the carotenoids during each bacterial doubling. The total carotenoids did not lose radioactivity when grown in the absence of 14C for 2.5 bacterial doublings. The total carotenoids did not lose radioactivity when grown in the absence of 14C for 2.5 bacterial doublings. The incorporation and turnover of 14C indicated the carotenes were sequentially desaturated and hydroxylated to form the polar carotenoids. PMID:5423369

  13. Study of the $\\Lambda p$ Interaction Close to the $\\Sigma^+n$ and $\\Sigma^0p$ Thresholds

    CERN Document Server

    Machner, H; Hinterberger, F; Magiera, A; Niskanen, J A; Ritman, J; Siudak, R

    2013-01-01

    The $\\Lambda p$ interaction close to the $\\Sigma N$ threshold is considered. Specifically, the pronounced structure seen in production reactions like $K^-d \\to \\pi^- \\Lambda p$ and $pp\\to K^+ \\Lambda p$ around the $\\Sigma N$ threshold is analyzed. Modern interaction models of the coupled $\\Lambda N - \\Sigma N$ systems generate such a structure either due to the presence of a (deuteron-like) unstable bound state or of an inelastic virtual state. % A determination of the position of the prominent peak as observed in various experiments for the two aforementioned reactions leads to values that agree quite well with each other. Furthermore, the deduced mean value of $2128.7\\pm 0.3$ MeV for the peak position coincides practically with the threshold energy of the $\\Sigma^+ n$ channel. This supports the interpretation of the structure as a genuine cusp, signaling an inelastic virtual state in the $^3S_1-^3D_1$ partial wave of the $\\Sigma N$ isospin 1/2 channel. % There is also evidence for a second peak (or shoulder...

  14. Incidence and function of sigma factors in Ralstonia metallidurans and other bacteria.

    Science.gov (United States)

    Nies, Dietrich H

    2004-04-01

    Bacterial sigma factors are essential for directing the bacterial RNA polymerase to promoter regions during transcription initiation. Genomic sequencing of the highly heavy-metal-resistant beta-proteobacterium Ralstonia metallidurans strain CH34 revealed 17 candidate genes for sigma factors. This review compares the sigma factor machinery of R. metallidurans to that of other bacteria. The sigma factors of 105 bacterial genomes were assigned to sigma factor clusters and families formed around the factors from Escherichia coli, Bacillus subtilis, and R. metallidurans. Genes for between 1 and 65 sigma-factor-related proteins were found in these genomes. Although prediction of sigma factor function from sequence comparisons can be misleading, organization of the R. metallidurans sigma factors into clusters and protein families, together with a discussion of the physiological function of members of these clusters, might yield insight into the cellular roles of bacterial sigma factors and the genes that depend on them for their expression.

  15. Improving standards and labels with IPMVP and Six Sigma strategies

    Energy Technology Data Exchange (ETDEWEB)

    Mowris, Robert; Jones, Ean [Robert Mowris and Associates (United States); Carlson, Kathleen [Verified, Inc. (United States)

    2007-07-01

    Efforts to improve energy efficiency and mitigate global warming through equipment and appliance standards and labels have been somewhat hampered by differences in energy consumption between actual and labeled energy use. In some cases actual energy use is 50 to 200 % greater than labeled energy use. The International Performance Measurement and Verification Protocol (IPMVP) can be used to evaluate standards and labels to improve performance. The California Public Utilities Commission, NYSERDA, the World Bank, and many state and federal agencies require adherence to IPMVP. The World Resources Inst. is recommending evaluation standards such as IPMVP for the Kyoto Protocol. Greenhouse gas trading policy encourages rigorous EM and V by applying savings discount factors tied to IPMVP Options. Efforts to increase customer satisfaction, resource efficiency, and improve profitability have motivated businesses worldwide to adopt Six Sigma strategies. Motorola, General Electric, Sony, Honda, Toyota, and many other companies have adopted Six Sigma to decrease costs and increase profitability and market share. Companies implementing Six Sigma find that 70 to 80 percent of the total cost of a product or service is determined in the design stage. The higher the quality of energy efficiency designed into a product, the lower its lifecycle costs. IPMVP and Six Sigma share similar objectives with respect to reducing lifecycle costs and improving performance through measurement and verification of quality and efficiency improvements. IPMVP provides a framework to measure and verify energy efficiency performance. Six Sigma strategies provide a framework to measure and verify energy savings and performance metrics at critical steps in the market chain (i.e., design, manufacturing, installation, and service). Incorporating IPMVP and Six Sigma into appliance standards and labels will improve reliability and ensure that labeled energy use is closer to actual energy use.

  16. Molecular regulation of tst superantigen expression by global regulatory systems in Staphylococcus aureus

    OpenAIRE

    Andrey, Diego Olivier

    2011-01-01

    Staphylocoque doré est un dangereux pathogène, capable de diverses formes d’infections, dont le Toxic Shock Syndrome. Ce travail étudie la régulation génique de tst, codant TSST-1, la toxine du Toxic Shock, au niveau moléculaire. Bien que situé sur un élément génétique mobile, les résultats montrent que tst est finement régulée et de manière complexe par les voies de régulation endogènes suivantes : SarA (S. aureus accessory regulator), le facteur de stress sigmaB, SarS, le senseur du quorum ...

  17. Structural Multi-objective Probabilistic Design for Six Sigma

    Institute of Scientific and Technical Information of China (English)

    LI Yu-qiang; CUI Zhen-shan; CHEN Jun; ZHANG Dong-juan; RUAN Xue-yu

    2007-01-01

    Uncertainties in engineering design may lead to low reliable solutions that also exhibit high sensitivity to uncontrollable variations. In addition, there often exist several conflicting objectives and constraints in various design environments. In order to obtain solutions that are not only "multi-objectively" optimal, but also reliable and robust, a probabilistic optimization method was presented by integrating six sigma philosophy and multi-objective genetic algorithm. With this method, multi-objective genetic algorithm was adopted to obtain the global Pareto solutions, and six sigma method was used to improve the reliability and robustness of those optimal solutions. Two engineering design problems were provided as examples to illustrate the proposed method.

  18. CMOS sigma-delta converters practical design guide

    CERN Document Server

    De la Rosa, Jose M

    2013-01-01

    A comprehensive overview of Sigma-Delta Analog-to-Digital Converters (ADCs) and a practical guide to their design in nano-scale CMOS for optimal performance. This book presents a systematic and comprehensive compilation of sigma-delta converter operating principles, the new advances in architectures and circuits, design methodologies and practical considerations - going from system-level specifications to silicon integration, packaging and measurements, with emphasis on nanometer CMOS implementation. The book emphasizes practical design issues - from high-level behavioural modelling i

  19. Precision measurement of the {Sigma}{sup 0} hyperon mass

    Energy Technology Data Exchange (ETDEWEB)

    Wang, M.H.; Hartouni, E.P.; Kreisler, M.N.; Uribe, J.; Church, M.D.; Gottschalk, E.E.; Knapp, B.C.; Stern, B.J.; Wiencke, L.R.; Christian, D.C.; Gutierrez, G.; Wehmann, A.; Avilez, C.; Felix, J.; Moreno, G.; Forbush, M.; Huson, F.R.; White, J.T. [BNL E766 Collaboration (United States)

    1998-10-01

    Using pp{r_arrow}p+ all charged particles at 800 GeV/c and 27.5 GeV/c incident protons at Fermilah and Brookhaven, respectively, the mass of the {Sigma}{sup 0} hyperon has been measured with an uncertainty of 7 times smaller than the best previous result. This result, M{sub {Sigma}{sup 0}}=1192.65{plus_minus}0.020{plus_minus}0.014 MeV/c{sup 2} is based on 16 times the statistics of previous results. {copyright} {ital 1998 American Institute of Physics.}

  20. The Present Status on sigma and kappa Meson Properties

    CERN Document Server

    Ishida, M

    2003-01-01

    The recent experimental data of both pipi / Kpi scattering and production processes, suggesting the existence of scalar sigma and kappa mesons, are reviewed. In many pipi /Kpi production processes the direct effects of their productions are observed, while they are, because of chiral symmetry, hidden in scattering processes, and now sigma(500--600) and kappa(800--900) are considered to be confirmed experimentally. The recent criticism on our method of analyses, which is based on the long believed prejudice of universal pipi / Kpi phase through scattering and production amplitudes, is explained not to be valid.

  1. A Mathematical Theory of the Gauged Linear Sigma Model

    CERN Document Server

    Fan, Huijun; Ruan, Yongbin

    2015-01-01

    We construct a rigorous mathematical theory of Witten's Gauged Linear Sigma Model (GLSM). Our theory applies to a wide range of examples, including many cases with non-Abelian gauge group. Both the Gromov-Witten theory of a Calabi-Yau complete intersection X and the Landau-Ginzburg dual (FJRW-theory) of X can be expressed as gauged linear sigma models. Furthermore, the Landau-Ginzburg/Calabi-Yau correspondence can be interpreted as a variation of the moment map or a deformation of GIT in the GLSM. This paper focuses primarily on the algebraic theory, while a companion article will treat the analytic theory.

  2. A Delta-Sigma beamformer with integrated apodization

    DEFF Research Database (Denmark)

    Tomov, Borislav Gueorguiev; Stuart, Matthias Bo; Hemmsen, Martin Christian;

    2013-01-01

    This paper presents a new design of a discrete time Delta-Sigma (ΔΣ) oversampled ultrasound beamformer which integrates individual channel apodization by means of variable feedback voltage in the Delta-Sigma analog to digital (A/D) converters. The output bit-width of each oversampled A/D converter....... The performance is evaluated by comparing the width of the wire images at half amplitude and the noise level of the images. The ΔΣ beamformer resolution has been found to be identical to that of the multi-bit A/D beamforming architecture, while the noise floor is elevated by approximately 6 dB....

  3. THE STORY OF SIGMA HYPERNUCLEI - A MODERN FABLE.

    Energy Technology Data Exchange (ETDEWEB)

    CHRIEN,R.E.

    1999-02-19

    The reality of {Sigma} hypernuclei has been the subject of intense concern among experimenters and theoreticians for more than 20 years. The possible existence of {Sigma} hypernuclei was first suggested by a pioneering experiment on a {sup 9}Be target at the CERN PS. There were reported to be two narrow ({Gamma} < 8 MeV) peaks in the continuum region. This finding was quite unexpected since the widths of {Sigma} states were believed to be large due to the strong conversion process. It is obvious that if such relatively long-lived systems were confirmed unambiguously by experiment, their masses and widths provide important constraints on the {Sigma}N effective interaction and its relation to the {Lambda}N and NN interactions. Since the {Sigma} carries isospin, the role of isospin and isospin conservation in hadronic reactions could be explored. This report stimulated a number of subsequent experiments at the BNL-AGS and KEK, along with further experiments with a specially created short kaon beam at the CERN PS. Experimental data were reported for different targets at different momenta and at different conditions. Various tagging techniques were employed to suppress backgrounds, but always at the expense of a reduction in statistical quality. Because of problems with resolution and statistics, contradictions among the different sets of data resulted more often in clouding the issues than clarifying them. Thus, up until a few years ago, there was no statistically clear confirmation of this surprising finding. In the last few years, however, a series of definitive experiments has been performed at the BNL-AGS in an effort to resolve the discrepancies and settle the controversy. Besides repeating the initial experiment on Be, a target of {sup 6}Li was run. The earlier stopped kaon data on {sup 4}He was repeated in an in-flight experiment, and the suggestion of a {Sigma} bound state, with virtually pure isospin, confirmed. We now have a better understanding of the role

  4. Order cycle time reduction : logistics lean six sigma aplication

    OpenAIRE

    Alberto Graça Lopes Peixoto Neto

    2008-01-01

    Resumo: Este trabalho tem o objetivo de mostrar a eficiência da aplicação da metodologia Lean Six Sigma na Logística, isto é, mais especificamente na redução do tempo de atendimento a pedidos. Tanto o Lean quanto o Six Sigma, até então aplicados de maneira isolada, tinham reduzido significativamente o nível das perdas (estoques) ou melhorado a velocidade dos processos ou reduzido a variabilidade. Porém, se fazia necessária uma abordagem diferente e completa para se reduzir ainda mais o lead t...

  5. Remarks on the pion-nucleon sigma-term

    CERN Document Server

    Hoferichter, Martin; Kubis, Bastian; Meißner, Ulf-G

    2016-01-01

    The pion-nucleon $\\sigma$-term can be stringently constrained by the combination of analyticity, unitarity, and crossing symmetry with phenomenological information on the pion-nucleon scattering lengths. Recently, lattice calculations at the physical point have been reported that find lower values by about $3\\sigma$ with respect to the phenomenological determination. We point out that a lattice measurement of the pion-nucleon scattering lengths could help resolve the situation by testing the values extracted from spectroscopy measurements in pionic atoms.

  6. A lattice determination of Sigma-Lambda mixing

    Energy Technology Data Exchange (ETDEWEB)

    Horsley, R. [Edinburgh Univ. (United Kingdom). School of Physics and Astronomy; Najjar, J. [Regensburg Univ. (Germany). Institut fuer Theoretische Physik; Nakamura, Y. [RIKEN Advanced Institute for Computational Science, Kobe (Japan); Perlt, H.; Schiller, A. [Leipzig Univ. (Germany). Inst. fuer Theoretische Physik; Pleiter, D. [Forschungszentrum Juelich (Germany). Juelich Supercomputer Centre; Rakow, P.E.L. [Liverpool Univ. (United Kingdom). Theoretical Physics Division; Schierholz, G. [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany); Stueben, H. [Hamburg Univ. (Germany). Regionales Rechenzentrum; Zanotti, J.M. [Adelaide Univ. (Australia). CSSM, Dept. of Physics; Collaboration: QCDSF-UKQCD Collaboration

    2014-11-15

    Isospin breaking effects in baryon octet (and decuplet) masses are due to a combination of up and down quark mass differences and electromagnetic effects and lead to small mass splittings. Between the Sigma and Lambda this mass splitting is much larger, this being mostly due to their different wavefunctions. However when isospin is broken, there is a mixing between between these states. We describe the formalism necessary to determine the QCD mixing matrix and hence find the mixing angle and mass splitting between the Sigma and Lambda particles due to QCD effects.

  7. Added value in health care with six sigma.

    Science.gov (United States)

    Lenaz, Maria P

    2004-06-01

    Six sigma is the structured application of the tools and techniques of quality management applied on a project basis that can enable organizations to achieve superior performance and strategic business results. The Greek character sigma has been used as a statistical term that measures how much a process varies from perfection, based on the number of defects per million units. Health care organizations using this model proceed from the lower levels of quality performance to the highest level, in which the process is nearly error free.

  8. NF-kappaB dependent cytokine levels in saliva of patients with oral preneoplastic lesions and oral squamous cell carcinoma.

    Science.gov (United States)

    Rhodus, Nelson L; Ho, Vu; Miller, Craig S; Myers, Sandra; Ondrey, Frank

    2005-01-01

    Previous investigations in our laboratory and others (Chen et al., 1998) have shown that the levels of certain inflammatory, proangiogenic cytokines in saliva and tissue specimens of patients with oral premalignant lesions (OPML) are elevated. We have also shown that these cytokines are elevated in tissue culture of oral squamous cell carcinoma (OSCC) cell lines. The purpose of this pilot study was to determine the level of several inflammatory, NF-kappaB-dependent cytokines in whole unstimulated saliva (WUS), in subjects with OPML as compared to those with diagnosed OSCC. Subjects (n=13) with OMPL, OSCC (n=13), and age-sex matched controls without oral lesions (C) (n=13) were enrolled. The mean age was 58.7 years. WUS was collected by standard techniques for 5 min (Navazesh, 1993). WUS samples were centrifuged and the cytokine analysis was performed on the supernatants by ELISA as previously described by Ondrey et al. (1991). The cytokines analyzed were: TNF-alpha, interleukin-1, interleukin-6, and interleukin-8 (TNF-alpha, IL-1, IL-6, and IL-8). The results as analyzed by Pairwise t-tests revealed significant differences in the salivary levels of: (1) TNF-alpha: (mean+/-S.E.M.: TNF-alpha-OSSC=28.9+/-14.6* pcg/ml versus OPML=10.5+/-7.4* pcg/ml versus controls=3.0+/-1.0 pcg/ml; *p<0.01); (2) IL-1: (IL-1-OSSC=454.4+/-215.8* pcg/ml versus OPML=255.1+/-124.8* pcg/ml versus controls=173.2+/-66.9 pcg/ml; *p<0.01); (3) IL-6: (mean+/-S.E.M.: IL-6-OSSC=88.2+/-43.2* pcg/ml versus OPML=70.8+/-24.3* pcg/ml versus controls=1.4+/-1.0 pcg/ml; *p<0.001) and (4) IL-8 in saliva: (mean+/-S.E.M.: IL-8-OSSC=3154.1+/-1023.2* pcg/ml versus OPML=1918.2+/-899.1* pcg/ml versus controls=1580.7+/-789.0 pcg/ml; *p<0.001). There was a significant increase in the levels of all cytokines in the saliva of the OPML as compared to controls, and a significant difference in the cytokines of OSSC saliva compared to the OPML and controls. These results suggest that these proangiogenic, proinflammatory

  9. Influenza A virus inhibits type I IFN signaling via NF-kappaB-dependent induction of SOCS-3 expression.

    Directory of Open Access Journals (Sweden)

    Eva-K Pauli

    2008-11-01

    Full Text Available The type I interferon (IFN system is a first line of defense against viral infections. Viruses have developed various mechanisms to counteract this response. So far, the interferon antagonistic activity of influenza A viruses was mainly observed on the level of IFNbeta gene induction via action of the viral non-structural protein 1 (NS1. Here we present data indicating that influenza A viruses not only suppress IFNbeta gene induction but also inhibit type I IFN signaling through a mechanism involving induction of the suppressor of cytokine signaling-3 (SOCS-3 protein. Our study was based on the observation that in cells that were infected with influenza A virus and subsequently stimulated with IFNalpha/beta, phosphorylation of the signal transducer and activator of transcription protein 1 (STAT1 was strongly reduced. This impaired STAT1 activation was not due to the action of viral proteins but rather appeared to be induced by accumulation of viral 5' triphosphate RNA in the cell. SOCS proteins are potent endogenous inhibitors of Janus kinase (JAK/STAT signaling. Closer examination revealed that SOCS-3 but not SOCS-1 mRNA levels increase in an RNA- and nuclear factor kappa B (NF-kappaB-dependent but type I IFN-independent manner early in the viral replication cycle. This direct viral induction of SOCS-3 mRNA and protein expression appears to be relevant for suppression of the antiviral response since in SOCS-3 deficient cells a sustained phosphorylation of STAT1 correlated with elevated expression of type I IFN-dependent genes. As a consequence, progeny virus titers were reduced in SOCS-3 deficient cells or in cells were SOCS-3 expression was knocked-down by siRNA. These data provide the first evidence that influenza A viruses suppress type I IFN signaling on the level of JAK/STAT activation. The inhibitory effect is at least in part due to the induction of SOCS-3 gene expression, which results in an impaired antiviral response.

  10. Defects in ErbB-dependent establishment of adult melanocyte stem cells reveal independent origins for embryonic and regeneration melanocytes.

    Directory of Open Access Journals (Sweden)

    Keith A Hultman

    2009-07-01

    Full Text Available Adult stem cells are responsible for maintaining and repairing tissues during the life of an organism. Tissue repair in humans, however, is limited compared to the regenerative capabilities of other vertebrates, such as the zebrafish (Danio rerio. An understanding of stem cell mechanisms, such as how they are established, their self-renewal properties, and their recruitment to produce new cells is therefore important for the application of regenerative medicine. We use larval melanocyte regeneration following treatment with the melanocytotoxic drug MoTP to investigate these mechanisms in Melanocyte Stem Cell (MSC regulation. In this paper, we show that the receptor tyrosine kinase, erbb3b, is required for establishing the adult MSC responsible for regenerating the larval melanocyte population. Both the erbb3b mutant and wild-type fish treated with the ErbB inhibitor, AG1478, develop normal embryonic melanocytes but fail to regenerate melanocytes after MoTP-induced melanocyte ablation. By administering AG1478 at different time points, we show that ErbB signaling is only required for regeneration prior to MoTP treatment and before 48 hours of development, consistent with a role in establishing MSCs. We then show that overexpression of kitla, the Kit ligand, in transgenic larvae leads to recruitment of MSCs, resulting in overproliferation of melanocytes. Furthermore, kitla overexpression can rescue AG1478-blocked regeneration, suggesting that ErbB signaling is required to promote the progression and specification of the MSC from a pre-MSC state. This study provides evidence that ErbB signaling is required for the establishment of adult MSCs during embryonic development. That this requirement is not shared with the embryonic melanocytes suggests that embryonic melanocytes develop directly, without proceeding through the ErbB-dependent MSC. Moreover, the shared requirement of larval melanocyte regeneration and metamorphic melanocytes that develops at

  11. Mass and width of sigma(750) scalar meson from measurements of pi(-)p->pi(-)pi(+)n on polarized target

    OpenAIRE

    Svec, M.

    1997-01-01

    Model independent amplitude analyses of $\\pi^- p_\\uparrow \\to \\pi^- \\pi^+ n$ on polarized target at 17.2 GeV/c reveal resonant structure of S-wave transversity amplitudes $|\\bar S|^2\\Sigma$ and $|S|^2\\Sigma$ near 750 MeV. Simultaneous fit to $|\\bar S|^2\\Sigma$ and $|S|^2\\Sigma$ with a single $\\sigma$ pole yields $m_\\sigma = 775 \\pm 17$ MeV and $\\Gamma_\\sigma = 147 \\pm 33$ MeV. Simultaneous fit with two common $\\sigma$ poles yields a lower $\\chi^2/dpt$. Their resonance parameters are $m_\\sigma...

  12. Aplicação da metodologia Lean Six Sigma para melhoria de um processo produtivo

    OpenAIRE

    Augusto Schaffer

    2016-01-01

    O Lean Six Sigma é a metodologia originada a partir da integração das metodologias Lean e Six Sigma. O Lean Six Sigma procura eliminar as perdas e reduzir os defeitos, agregando os benefícios de cada uma das duas metodologias que a dão origem. O objetivo deste trabalho é aplicar a metodologia Lean Six Sigma para melhoria de um processo produtivo. Neste trabalho é apresentada uma revisão bibliográfica sobre as metodologias Lean e Six Sigma, buscando a compreensão das origens do Lean Six Sigma,...

  13. Purification and activities of the Rhodobacter capsulatus RpoN (sigma N) protein.

    Science.gov (United States)

    Cannon, W; Missailidis, S; Austin, S; Moore, M; Drake, A; Buck, M

    1996-07-01

    The rpoN-encoded sigma factors (sigma N) are a distinct class of bacterial sigma factors, with no obvious homology to the major sigma 70 class. The sigma N-containing RNA polymerase holoenzyme functions in enhancer-dependent transcription to allow expression of positively controlled genes. We have purified the Rhodobacter capsulatus sigma N protein, which is distinctive in lacking an acidic region implicated in the melting of promoter DNA by the Escherichia coll sigma N holoenzyme, and may represent a minor subclass of sigma N proteins. Assays of promoter recognition and holoenzyme formation and function showed that the purified R. capsulatus sigma N protein is distinct in activity compared to the enteric proteins, but retains the broad functions described for these proteins. As first described for the Klebsiella pneumoniae protein, promoter recognition in the absence of core RNA polymerase was detected, but contact of certain promoter bases by the R. capsulatus sigma N protein and its response to core RNA polymerase was clearly different from that determined for the K. pneumoniae and E. coli proteins. Results are discussed in the context of a requirement to modulate the activity of the DNA-binding surfaces of sigma N to regulate sigma N function. Circular dichroism was used to evaluate the structure of the R. capsulatus protein and revealed differences in the tertiary signals as compared to the K. pneumoniae protein, some of which are attributable to the DNA-binding domain of sigma N.

  14. Why all this fuss over a few Sigma ?

    CERN Multimedia

    Patrice Loïez

    2001-01-01

    Sigma, the standard deviation, is the quantity used most often by physicists to express the strength of evidence for a new phenomenon. It is the way they measure the distance between the data observed and the data expected if there were no new phenomenon. What that means is best understood by taking a more familiar example : toss a fair coin (See Bulletin)

  15. Strategically Focused Training in Six Sigma Way: A Case Study

    Science.gov (United States)

    Pandey, Ashish

    2007-01-01

    Purpose: The purpose of the current study is to examine the utility of Six Sigma interventions as a performance measure and explore its applicability for making the training design and delivery operationally efficient and strategically effective. Design/methodology/approach: This is a single revelatory case study. Data were collected from multiple…

  16. Using Six-Sigma To Change and Measure Improvement.

    Science.gov (United States)

    Feld, Karl G.; Stone, William K.

    2002-01-01

    Explains why Honeywell's Market Research Department replaced its traditional data collection and paper-based tabulation with blended modes, including electronic interviewing and real-time reporting. Describes how the Six-Sigma quality control process demonstrated that a hybrid approach with blended modes and Web-based reporting tools could deliver…

  17. Six Sigma in Health Care: Lessons learned from a Hospital

    NARCIS (Netherlands)

    van den Heuvel, J.; Does, R.J.M.M.; Verver, J.P.S.

    2005-01-01

    Six Sigma is a quality improvement approach aimed at optimising processes while reducing defects and costs. It has been developed and is widely used in industry and recently has been introduced, on a limited scale, in healthcare. In this article, we discuss the results of the implementation of Six S

  18. Applying Lean and Six Sigma in financial service

    NARCIS (Netherlands)

    Does, R.J.M.M.; de Koning, H.; Anthony, J.; Kumar, M.

    2006-01-01

    Abstract Lean and Six Sigma have gone through parallel developments in recent years. Originally applied to a small range of industries, both approaches are now also used widely in healthcare, administration and service. A recent development is the integration of the two approaches. In this paper we

  19. Three-body system of $\\pi \\pi \\Sigma_c$

    CERN Document Server

    Long, Bingwei

    2016-01-01

    The existence of near-threshold charmed baryon $\\Lambda_c^+(2595)$ implies the pion and the lightest, isospin-$1$ charmed baryon $\\Sigma_c$ interact very strongly at extremely low energies. Using the two-flavor version of heavy hadron chiral perturbation theory, I explore the direct consequences of this strong force by investigating whether the $\\Sigma_c$ can trap two very soft pions to form any visible hadronic states. The answer is positive. It is found without tuning any free parameters or ultraviolet cutoff that the state in question, with quantum numbers $I(J^P) = 1({\\frac{1}{2}}^+)$, presents itself as a resonance pole only a few MeVs away from the $\\pi \\pi \\Sigma_c$ threshold. Subleading corrections are estimated with power-counting arguments, and the smallness of pion momenta is found to facilitate the reliability of the analysis. Because of its proximity in mass, this excited $\\Sigma_c$ resonance is speculated to be related to the broad resonance labeled as $\\Lambda_c^+(2765)$.

  20. Sigma phase formation kinetics in stainless steel laminate composites

    Energy Technology Data Exchange (ETDEWEB)

    Wenmen, D.W.; Olson, D.L.; Matlock, D.K. [Colorado School of Mines, Golden, CO (United States)] [and others

    1994-12-31

    Stainless steel laminate composites were made to simulate weld microstructures. The use of laminates with variations in chemical composition allows for one dimensional analysis of phase transformation associated with the more complex three-dimensional solidification experience of weld metal. Alternate layers of austenitic (304L and 316L) and ferritic (Ebrite) stainless steels allowed for the study of sigma phase formation at the austenite-ferrite interface in duplex stainless steel. Two austenitic stainless steels, 304L (18.5Cr-9.2Ni-0.3Mo) and 316L (16.2Cr-10.1Ni-2.6Mo), and one ferritic stainless steel, Ebrite (26.3Cr-0Ni-1.0Mo) were received in the form of sheet which was laboratory cold rolled to a final thickness of 0.25 mm (0.030 in.). Laminate composites were prepared by laboratory hot rolling a vacuum encapsulated compact of alternating layers of the ferrite steel with either 304L or 316L stainless steel sheets. Laminate composite specimens, which simulate duplex austenite-ferrite weld metal structure, were used to establish the kinetics of nucleation and growth of sigma phase. The factors affecting sigma phase formation were identified. The effects of time, temperature, and transport of chromium and nickel were evaluated and used to establish a model for sigma phase formation in the austenite-ferrite interfacial region. Information useful for designing stainless steel welding consumables to be used for high temperature service was determined.

  1. Inter-industry generic Lean Six Sigma project definitions

    NARCIS (Netherlands)

    Lameijer, B.A.; Does, R.J.M.M.; de Mast, J.

    2016-01-01

    Purpose - The objective of this research is to provide practitioners with inter-industry applicable rules and guidelines for the Lean Six Sigma (LSS) project definition phase. This research resulted in 13 inter-industry generic project definitions that are divided by four performance dimensions: qua

  2. Shake for Sigma, Pray for Pi: Classroom Orbital Overlap Analogies

    Science.gov (United States)

    Dicks, Andrew P.

    2011-01-01

    An introductory organic classroom demonstration is discussed where analogies are made between common societal hand contact and covalent bond formation. A handshake signifies creation of a [sigma] bond ("head-on" orbital overlap), whereas the action of praying illustrates "sideways" overlap and generation of a [pi] bond. The nature of orbital and…

  3. Beam asymmetry $\\Sigma$ measurements on the $\\pi^-$ photoproduction off neutrons

    CERN Document Server

    Mandaglio, G; Manganaro, M; Bellini, V; Bocquet, J P; Casano, L; D'Angelo, A; Di Salvo, R; Fantini, A; Franco, D; Gervino, G; Ghio, F; Giardina, G; Girolami, B; Giusa, A; Ignatov, A; Lapik, A; Sandri, P Levi; Lleres, A; Moricciani, D; Mushkarenkov, A N; Nedorezov, V; Randieri, C; Rebreyend, D; Rudnev, N V; Russo, G; Schaerf, C; Sperduto, M L; Sutera, M C; Turinge, A; Vegna, V; Briscoe, W J; Strakovsky, I I

    2010-01-01

    The $\\Sigma$ beam asymmetry in the photoproduction of negative pions from quasi-free neutrons in a deuterium target was measured at Graal in the energy interval 700 - 1500 MeV and a wide angular range, using polarized and tagged photons. The results are compared with recent partial wave analyses.

  4. SIGMA Release v1.2 - Capabilities, Enhancements and Fixes

    Energy Technology Data Exchange (ETDEWEB)

    Mahadevan, Vijay [Argonne National Lab. (ANL), Argonne, IL (United States); Grindeanu, Iulian R. [Argonne National Lab. (ANL), Argonne, IL (United States); Ray, Navamita [Argonne National Lab. (ANL), Argonne, IL (United States); Jain, Rajeev [Argonne National Lab. (ANL), Argonne, IL (United States); Wu, Danqing [Argonne National Lab. (ANL), Argonne, IL (United States)

    2015-09-30

    In this report, we present details on SIGMA toolkit along with its component structure, capabilities, and feature additions in FY15, release cycles, and continuous integration process. These software processes along with updated documentation are imperative to successfully integrate and utilize in several applications including the SHARP coupled analysis toolkit for reactor core systems funded under the NEAMS DOE-NE program.

  5. Generic Lean Six Sigma project definitions in financial services

    NARCIS (Netherlands)

    H. de Koning; J. de Mast; R.J.M.M. Does; T. Vermaat; S. Simons

    2008-01-01

    Lean Six Sigma (LSS) is applied in financial service organizations to improve operational efficiency and effectiveness. LSS prescribes that these improvements are designed and implemented by projects. The purpose of this article is to facilitate the process of defining LSS projects in finance, becau

  6. Nonlinearities in SC Delta-Sigma A/D Converters

    DEFF Research Database (Denmark)

    Steensgaard-Madsen, Jesper

    1998-01-01

    The effects of using nonlinear low-gain opamps in switched-capacitor delta-sigma modulators are analyzed. Using unconventional topologies, the state variables are made essentially uncorrelated with the input signal, hence opamp nonlinearity will cause very little harmonic distortion. Nonlinearity...

  7. High Speed and Wide Bandwidth Delta-Sigma ADCs

    NARCIS (Netherlands)

    Bolatkale, M.

    2013-01-01

    This thesis describes the theory, design and implementation of a high-speed, high-performance continuous-time delta-sigma (CTΔΣ) ADC for applications such as medical imaging, high-definition video processing, and wireline and wireless communications. In order to achieve a GHz clocking speed, this th

  8. On the morphology of sigma-drop galaxies

    CERN Document Server

    Comerón, S; Beckman, J E

    2008-01-01

    Context: Local reductions of the stellar velocity dispersion in the central regions of galaxies are known as sigma-drops. Knowing the origin of these features can lead to better understanding of inner galactic dynamics. Aims: We present a sample of 20 sigma-drop galaxies matched with a control sample of galaxies without sigma-drop in order to search for correlations between sigma-drops and the properties, primarily morphological, of the nuclear zones and discs of their host galaxies. Methods: We study the dust and Halpha distribution at 0.1 arcsec scale, using Hubble Space Telescope imaging, in the circumnuclear zones of the two samples of galaxies, searching for differences and trying to establish a link between the nuclear kinematics and the host morphology. We have also considered the CO and HI emission of the galaxies and their luminosity profiles. Results: We classify the two samples following both morphological parameters and the luminosity profiles. We find a larger fraction of nuclear dust spirals and...

  9. Goldberger-treiman relation in the renormalized sigma model

    NARCIS (Netherlands)

    Strubbe, H.J.

    1972-01-01

    The regularization and renormalization of the full sigma model is worked out explicitly in the tree and one-loop approximation. Various renormalized quantities relevant for chiral symmetry breaking are listed. The numerically calculated Goldberger-Treiman relation is also compared with experiment.

  10. Improved actions for the two-dimensional sigma-model

    OpenAIRE

    Caracciolo, Sergio; Montanari, Andrea; Pelissetto, Andrea

    1997-01-01

    For the O(N) sigma-model we studied the improvement program for actions with two- and four-spin interactions. An interesting example is an action which is reflection-positive, on-shell improved, and has all the coupling defined on an elementary plaquette. We show the large N solution and preliminary Monte Carlo results for N=3.

  11. Main-Seqence Fitting Distance to the sigma Ori Cluster

    CERN Document Server

    Sherry, W H; Wolk, S J; Adams, N R

    2008-01-01

    The sigma Ori cluster is an unbound aggregate of a few hundred young, low-mass stars centered on the multiple system sigma Ori. This cluster is of great interest because it is at an age when roughly half of the stars have lost their protoplanetary disks, and the cluster has a very large population of brown dwarfs. One of the largest sources of uncertainty in the properties of the cluster is that the distance is not well known. The directly measured Hipparcos distance to sigma Ori AB is 350 (+120,-90) pc. On the other hand, the distance to the Orion OB1b subgroup (of which sigma Ori is thought to be a member), 473+/-40 pc, is far better determined, but it is an indirect estimate of the cluster's distance. Also, Orion OB1b may have a depth of 40 pc along our line of sight. We use main sequence fitting to 9 main sequence cluster members to estimate a best fit distance of 420+/-30 pc, assuming a metallicity of -0.16+/-0.11 or 444 pc assuming solar metallicity. A distance as close as 350 pc is inconsistent with th...

  12. ROSAT observations of the RSCVn binary sigma Geminorum

    DEFF Research Database (Denmark)

    Yi, Z.; Elgaroy, O.; Engvold, O.

    1997-01-01

    X-ray observations of the RSCVn system sigma Geminorum have been undertaken with the ROSAT observatory. Several spectra of very good signal-to-noise ratio were obtained. Spectral fitting using metal abundances amounting to 50% of solar values reveal two temperature components at 2 MK and 12 MK. P...

  13. The Moduli Space in the Gauged Linear Sigma Model

    CERN Document Server

    Fan, Huijun; Ruan, Yongbin

    2016-01-01

    This is a survey article for the mathematical theory of Witten's Gauged Linear Sigma Model, as developed recently by the authors. Instead of developing the theory in the most general setting, in this paper we focus on the description of the moduli.

  14. Thermodynamics of O(N) sigma models : 1/N corrections

    NARCIS (Netherlands)

    Andersen, JO; Boer, D; Warringa, HJ

    2004-01-01

    The thermodynamics of the O(N) linear and nonlinear sigma models in 3+1 dimensions is studied. We calculate the pressure to next-to-leading order in the 1/N expansion and show that at this order, temperature-independent renormalization is only possible at the minimum of the effective potential. The

  15. Locally supersymmetric D=3 non-linear sigma models

    NARCIS (Netherlands)

    Wit, B. de; Tollsten, A. K.; Nicolai, H.

    1992-01-01

    We study non-linear sigma models with N local supersymmetries in three space-time dimensions. For N=1 and 2 the target space of these models is Riemannian or Kahler, respectively. All N>2 theories are associated with Einstein spaces. For N=3 the target space is quaternionic, while for N=4 it general

  16. On quantum equivalence of dual $\\sigma$ models $SL(3)$ examples

    CERN Document Server

    Horváth, Z; Palla, L

    1996-01-01

    The equivalence of several $SL(3)$ sigma models and their special Abelian duals is investigated in the two loop order of perturbation theory. The investigation is based on extracting and comparing various $\\beta$ functions of the original and dual models. The role of the discrete global symmetries is emphasized.

  17. On quantum equivalence of dual sigma models: SL(3) examples

    Energy Technology Data Exchange (ETDEWEB)

    Horvath, Z. [Lorand Eoetvoes Univ., Budapest (Hungary). Inst. for Theoretical Physics; Karp, R.L. [Lorand Eoetvoes Univ., Budapest (Hungary). Inst. for Theoretical Physics; Palla, L. [Lorand Eoetvoes Univ., Budapest (Hungary). Inst. for Theoretical Physics

    1997-04-14

    The equivalence of several SL(3) sigma models and their special Abelian duals is investigated in two-loop order of perturbation theory. The investigation is based on extracting and comparing various {beta}-functions of the original and dual models. The role of discrete global symmetries is emphasized. (orig.).

  18. Noise as a Boolean algebra of sigma-fields

    CERN Document Server

    Tsirelson, Boris

    2011-01-01

    The black noise of two-dimensional percolation, disclosed recently by O. Schramm, S. Smirnov and C. Garban, exceeds the limits of the existing framework based on one-dimensional intervals. A remake of the theory of noises, provided here, treats them as Boolean algebras of sigma-fields. Completeness of the Boolean algebra implies classicality, which answers an old question of J. Feldman.

  19. Gustav Naan ja Sigma Tau / Arvo Pesti, Madli Pesti

    Index Scriptorium Estoniae

    Pesti, Arvo, 1956-2010

    2009-01-01

    Füüsik, kosmoloog ja ühiskonnategelane Gustav Naanist. Merle Karusoo dokumentaallavastusest "Sigma Tau-C705", mis põhineb Enn Vetemaa ja Erki Aule näidendil "Gustav Naani hiilgus ja viletsus". Esietendus 16. märtsil 2008 Eesti Draamateatris

  20. A rational reconstruction of Six Sigma's Breakthrough Cookbook

    NARCIS (Netherlands)

    de Koning, H.; de Mast, J.

    2006-01-01

    Purpose: The purpose of this paper is to develop a consistent and crystallized exposition of Six-Sigma's methodology for improvement projects, which could serve as a basis for subsequent scientific research of the method. Design/methodology/approach: The paper shows that reformulation of imprecise a

  1. Using Six Sigma and Lean methodologies to improve OR throughput.

    Science.gov (United States)

    Fairbanks, Catharine B

    2007-07-01

    Improving patient flow in the perioperative environment is challenging, but it has positive implications for both staff members and for the facility. One facility in vermont improved patient throughput by incorporating Six Sigma and Lean methodologies for patients undergoing elective procedures. The results of the project were significantly improved patient flow and increased teamwork and pride among perioperative staff members.

  2. Lean-Six Sigma: tools for rapid cycle cost reduction.

    Science.gov (United States)

    Caldwell, Chip

    2006-10-01

    Organizational costs can be grouped as process cost, cost of quality, and cost of poor quality. Providers should train managers in the theory and application of Lean-Six Sigma, including the seven categories of waste and how to remove them. Healthcare financial executives should work with managers in eliminating waste to improve service and reduce costs.

  3. Generic Lean Six Sigma project definitions in publishing

    NARCIS (Netherlands)

    de Koning, H.; Does, R.J.M.M.; Groen, A.; Kemper, B.P.H.

    2010-01-01

    Purpose - Many companies in the publishing industry are facing the task of developing new business models and becoming more efficient and effective in execution. Lean Six Sigma (LSS) is a unified framework for systematically developing efficiency and quality improvements; it can help realize signifi

  4. Reply to "Comment on `Lattice determination of Sigma - Lambda mixing' "

    CERN Document Server

    Horsley, R; Nakamura, Y; Perlt, H; Pleiter, D; Rakow, P E L; Schierholz, G; Schiller, A; Stüben, H; Zanotti, J M

    2015-01-01

    In this Reply, we respond to the above Comment. Our computation [Phys. Rev. D 91 (2015) 074512] only took into account pure QCD effects, arising from quark mass differences, so it is not surprising that there are discrepancies in isospin splittings and in the Sigma - Lambda mixing angle. We expect that these discrepancies will be smaller in a full calculation incorporating QED effects.

  5. Single-Path Sigma from a Huge Dataset in Taiwan

    Science.gov (United States)

    Sung, Chih-Hsuan; Lee, Chyi-Tyi

    2014-05-01

    Ground-motion variability, which was used in the probabilistic seismic hazard analysis (PSHA) in computing annual exceedence probability, is composed of random variability (aleatory uncertainty) and model uncertainty (epistemic uncertainty). Finding random variability of ground motions has become an important issue in PSHA, and only the random variability can be used in deriving the annual exceedence probability of ground-motion. Epistemic uncertainty will be put in the logic tree to estimate the total uncertainty of ground-motion. In the present study, we used about 18,859 records from 158 shallow earthquakes (Mw > 3.0, focal depth ≤ 35 km, each station has at least 20 records) form the Taiwan Strong-Motion Instrumentation Program (TSMIP) network to analyse the random variability of ground-motion. First, a new ground-motion attenuation model was established by using this huge data set. Second, the residuals from the median attenuation were analysed by direct observation on inter-event variability and site-specific variability. Finally, the single-path variability was found by a moving-window method on either single-earthquake residuals or single-station residuals. A variogram method was also used to find minimum variability for intra-event residuals and inter-event residuals, respectively. Results reveal that 90% of the single-path sigma σSP are ranging from 0.219 to 0.254 (ln unit) and are 58% to 64% smaller than the total sigma (σT =0.601). The single-site sigma (σSS) are also 39%-43% smaller. If we use only random variability (single-path sigma) in PSHA, then the resultant hazard level would be 28% and 25% lower than the traditional one (using total sigma) in 475-year and in 2475-year return period, respectively, in Taipei.

  6. Staphylococcus aureus survival in human blood.

    Science.gov (United States)

    Malachowa, Natalia; DeLeo, Frank R

    2011-01-01

    Methicillin-resistant Staphylococcus aureus (MRSA) is abundant in hospitals and in the United States is a leading cause of mortality due to infectious agents. Community-associated MRSA (CA-MRSA) strains such as USA300, which typically cause disease outside of healthcare settings, are also prevalent in the United States. Although most CA-MRSA infections affect skin and soft tissue, the pathogen can enter the bloodstream and ultimately cause severe disease. In a recent paper, we used USA300-specific microarrays to generate a comprehensive view of the molecules that facilitate S. aureus immune evasion and survival in human blood. Notably, genes encoding proteins involved in iron-uptake and utilization and gamma-hemolysin (hlgABC) are highly up-regulated by USA300 during culture in human blood. Here we discuss the potential implication of these findings and the possible role of gamma-hemolysin in the success of S. aureus as a human pathogen.

  7. Genomics of Natural Populations of Staphylococcus aureus.

    Science.gov (United States)

    Fitzgerald, J Ross; Holden, Matthew T G

    2016-09-01

    Staphylococcus aureus is a major human pathogen and an important cause of livestock infections. The first S. aureus genomes to be published, 15 years ago, provided the first view of genome structure and gene content. Since then, thousands of genomes from a wide array of strains from different sources have been sequenced. Comparison of these sequences has resulted in broad insights into population structure, bacterial evolution, clone emergence and expansion, and the molecular basis of niche adaptation. Furthermore, this information is now being applied clinically in outbreak investigations to inform infection control measures and to determine appropriate treatment regimens. In this review, we summarize some of the broad insights into S. aureus biology gained from the analysis of genomes and discuss future directions and opportunities in this dynamic field of research.

  8. Study of $\\psi$ decays to the $\\Xi^{-}\\bar\\Xi^{+}$ and $\\Sigma(1385)^{\\mp}\\bar\\Sigma(1385)^{\\pm}$ final states

    CERN Document Server

    Ablikim, M; Ai, X C; Albayrak, O; Albrecht, M; Ambrose, D J; Amoroso, A; An, F F; An, Q; Bai, J Z; Ferroli, R Baldini; Ban, Y; Bennett, D W; Bennett, J V; Bertani, M; Bettoni, D; Bian, J M; Bianchi, F; Boger, E; Boyko, I; Briere, R A; Cai, H; Cai, X; Cakir, O; Calcaterra, A; Cao, G F; Cetin, S A; Chang, J F; Chelkov, G; Chen, G; Chen, H S; Chen, H Y; Chen, J C; Chen, M L; Chen, S J; Chen, X; Chen, X R; Chen, Y B; Cheng, H P; Chu, X K; Cibinetto, G; Dai, H L; Dai, J P; Dbeyssi, A; Dedovich, D; Deng, Z Y; Denig, A; Denysenko, I; Destefanis, M; De Mori, F; Ding, Y; Dong, C; Dong, J; Dong, L Y; Dong, M Y; Dou, Z L; Du, S X; Duan, P F; Fan, J Z; Fang, J; Fang, S S; Fang, X; Fang, Y; Farinelli, R; Fava, L; Fedorov, O; Feldbauer, F; Felici, G; Feng, C Q; Fioravanti, E; Fritsch, M; Fu, C D; Gao, Q; Gao, X L; Gao, X Y; Gao, Y; Gao, Z; Garzia, I; Goetzen, K; Gong, L; Gong, W X; Gradl, W; Greco, M; Gu, M H; Gu, Y T; Guan, Y H; Guo, A Q; Guo, L B; Guo, Y; Guo, Y P; Haddadi, Z; Hafner, A; Han, S; Hao, X Q; Harris, F A; He, K L; Held, T; Heng, Y K; Hou, Z L; Hu, C; Hu, H M; Hu, J F; Hu, T; Hu, Y; Huang, G S; Huang, J S; Huang, X T; Huang, Y; Hussain, T; Ji, Q; Ji, Q P; Ji, X B; Ji, X L; Jiang, L W; Jiang, X S; Jiang, X Y; Jiao, J B; Jiao, Z; Jin, D P; Jin, S; Johansson, T; Julin, A; Kalantar-Nayestanaki, N; Kang, X L; Kang, X S; Kavatsyuk, M; Ke, B C; Kiese, P; Kliemt, R; Kloss, B; Kolcu, O B; Kopf, B; Kornicer, M; Kupsc, A; Kühn, W; Lange, J S; Lara, M; Larin, P; Leng, C; Li, C; Li, Cheng; Li, D M; Li, F; Li, F Y; Li, G; Li, H B; Li, J C; Li, Jin; Li, K; Li, Lei; Li, P R; Li, Q Y; Li, T; Li, W D; Li, W G; Li, X L; Li, X N; Li, X Q; Li, Z B; Liang, H; Liang, Y F; Liang, Y T; Liao, G R; Lin, D X; Liu, B J; Liu, C X; Liu, D; Liu, F H; Liu, Fang; Liu, Feng; Liu, H B; Liu, H H; Liu, H M; Liu, J; Liu, J B; Liu, J P; Liu, J Y; Liu, K; Liu, K Y; Liu, L D; Liu, P L; Liu, Q; Liu, S B; Liu, X; Liu, Y B; Liu, Z A; Liu, Zhiqing; Loehner, H; Lou, X C; Lu, H J; Lu, J G; Lu, Y; Lu, Y P; Luo, C L; Luo, M X; Luo, T; Luo, X L; Lyu, X R; Ma, F C; Ma, H L; Ma, L L; Ma, Q M; Ma, T; Ma, X N; Ma, X Y; Ma, Y M; Maas, F E; Maggiora, M; Mao, Y J; Mao, Z P; Marcello, S; Messchendorp, J G; Min, J; Mitchell, R E; Mo, X H; Mo, Y J; Morales, C; Muchnoi, N Yu; Muramatsu, H; Nefedov, Y; Nerling, F; Nikolaev, I B; Ning, Z; Nisar, S; Niu, S L; Niu, X Y; Olsen, S L; Ouyang, Q; Pacetti, S; Pan, Y; Patteri, P; Pelizaeus, M; Peng, H P; Peters, K; Pettersson, J; Ping, J L; Ping, R G; Poling, R; Prasad, V; Qi, H R; Qi, M; Qian, S; Qiao, C F; Qin, L Q; Qin, N; Qin, X S; Qin, Z H; Qiu, J F; Rashid, K H; Redmer, C F; Ripka, M; Rong, G; Rosner, Ch; Ruan, X D; Santoro, V; Sarantsev, A; Savrié, M; Schoenning, K; Schumann, S; Shan, W; Shao, M; Shen, C P; Shen, P X; Shen, X Y; Sheng, H Y; Song, W M; Song, X Y; Sosio, S; Spataro, S; Sun, G X; Sun, J F; Sun, S S; Sun, Y J; Sun, Y Z; Sun, Z J; Sun, Z T; Tang, C J; Tang, X; Tapan, I; Thorndike, E H; Tiemens, M; Ullrich, M; Uman, I; Varner, G S; Wang, B; Wang, B L; Wang, D; Wang, D Y; Wang, K; Wang, L L; Wang, L S; Wang, M; Wang, P; Wang, P L; Wang, S G; Wang, W; Wang, W P; Wang, X F; Wang, Y D; Wang, Y F; Wang, Y Q; Wang, Z; Wang, Z G; Wang, Z H; Wang, Z Y; Weber, T; Wei, D H; Wei, J B; Weidenkaff, P; Wen, S P; Wiedner, U; Wolke, M; Wu, L H; Wu, Z; Xia, L; Xia, L G; Xia, Y; Xiao, D; Xiao, H; Xiao, Z J; Xie, Y G; Xiu, Q L; Xu, G F; Xu, L; Xu, Q J; Xu, Q N; Xu, X P; Yan, L; Yan, W B; Yan, W C; Yan, Y H; Yang, H J; Yang, H X; Yang, L; Yang, Y X; Ye, M; Ye, M H; Yin, J H; Yu, B X; Yu, C X; Yu, J S; Yuan, C Z; Yuan, W L; Yuan, Y; Yuncu, A; Zafar, A A; Zallo, A; Zeng, Y; Zeng, Z; Zhang, B X; Zhang, B Y; Zhang, C; Zhang, C C; Zhang, D H; Zhang, H H; Zhang, H Y; Zhang, J J; Zhang, J L; Zhang, J Q; Zhang, J W; Zhang, J Y; Zhang, J Z; Zhang, K; Zhang, L; Zhang, X Y; Zhang, Y; Zhang, Y H; Zhang, Y N; Zhang, Y T; Zhang, Yu; Zhang, Z H; Zhang, Z P; Zhang, Z Y; Zhao, G; Zhao, J W; Zhao, J Y; Zhao, J Z; Zhao, Lei; Zhao, Ling; Zhao, M G; Zhao, Q; Zhao, Q W; Zhao, S J; Zhao, T C; Zhao, Y B; Zhao, Z G; Zhemchugov, A; Zheng, B; Zheng, J P; Zheng, W J; Zheng, Y H; Zhong, B; Zhou, L; Zhou, X; Zhou, X K; Zhou, X R; Zhou, X Y; Zhu, K; Zhu, K J; Zhu, S; Zhu, S H; Zhu, X L; Zhu, Y C; Zhu, Y S; Zhu, Z A; Zhuang, J; Zotti, L; Zou, B S; Zou, J H

    2016-01-01

    We study the decays of the charmonium resonances $J/\\psi$ and $\\psi(3686)$ to the final states $\\Xi^{-}\\bar\\Xi^{+}$, $\\Sigma(1385)^{\\mp}\\bar\\Sigma(1385)^{\\pm}$ based on a single baryon tag method using data samples of $(223.7 \\pm 1.4) \\times 10^{6}$ $J/\\psi$ and $(106.4 \\pm 0.9) \\times 10^{6}$ $\\psi(3686)$ events collected with the BESIII detector at the BEPCII collider. The decay $\\psi(3686)\\rightarrow\\Sigma(1385)^{\\mp}\\bar\\Sigma(1385)^{\\pm}$ is observed for the first time, and the measurements of the other processes, including the branching fractions and angular distributions, are in good agreement with and much more precise than the previously published results. Additionally, the ratios $\\frac{{\\cal{B}}(\\psi(3686)\\rightarrow\\Xi^{-}\\bar\\Xi^{+})}{{\\cal{B}}(J/\\psi\\rightarrow\\Xi^{-}\\bar\\Xi^{+})}$, $\\frac{{\\cal{B}}(\\psi(3686)\\rightarrow\\Sigma(1385)^{-}\\bar\\Sigma(1385)^{+})}{{\\cal{B}}(J/\\psi\\rightarrow\\Sigma(1385)^{-}\\bar\\Sigma(1385)^{+})}$ and $\\frac{{\\cal{B}}(\\psi(3686)\\rightarrow\\Sigma(1385)^{+}\\bar\\Sigma(138...

  9. Measurements of the masses and widths of the $\\Sigma_{c}(2455)^{0/++}$ and $\\Sigma_{c}(2520)^{0/++}$ baryons

    CERN Document Server

    Lee, S -H; Won, E; Abdesselam, A; Adachi, I; Aihara, H; Asner, D M; Aushev, T; Ayad, R; Bakich, A M; Bala, A; Bansal, V; Bhardwaj, V; Bhuyan, B; Bonvicini, G; Bozek, A; Browder, T E; Červenkov, D; Chen, A; Cheon, B G; Chistov, R; Cho, K; Chobanova, V; Choi, S -K; Choi, Y; Cinabro, D; Dalseno, J; Danilov, M; Doležal, Z; Drásal, Z; Drutskoy, A; Eidelman, S; Epifanov, D; Farhat, H; Fast, J E; Ferber, T; Frey, A; Gaur, V; Gabyshev, N; Ganguly, S; Garmash, A; Gillard, R; Goh, Y M; Golob, B; Hayashii, H; He, X H; Hoshi, Y; Hyun, H J; Iijima, T; Ishikawa, A; Itoh, R; Iwasaki, Y; Iwashita, T; Jaegle, I; Julius, T; Kang, J H; Kawasaki, T; Kiesling, C; Kim, B H; Kim, D Y; Kim, J B; Kim, J H; Kim, M J; Kinoshita, K; Klucar, J; Kodyš, P; Korpar, S; Križan, P; Krokovny, P; Kuhr, T; Kumita, T; Kwon, Y -J; Lange, J S; Li, Y; Gioi, L Li; Libby, J; Liventsev, D; Matvienko, D; Miyabayashi, K; Miyata, H; Moll, A; Mori, T; Mussa, R; Nagasaka, Y; Nakano, E; Nakao, M; Nayak, M; Nedelkovska, E; Nisar, N K; Nishida, S; Nitoh, O; Ogawa, S; Okuno, S; Pakhlov, P; Pakhlova, G; Park, H K; Pedlar, T K; Peng, T; Pestotnik, R; Petrič, M; Piilonen, L E; Poluektov, A; Ribežl, E; Ritter, M; Röhrken, M; Rostomyan, A; Ryu, S; Sahoo, H; Saito, T; Sakai, K; Sakai, Y; Sandilya, S; Santel, D; Santelj, L; Sanuki, T; Sato, Y; Schneider, O; Schnell, G; Schwanda, C; Semmler, D; Senyo, K; Seon, O; Sevior, M E; Shapkin, M; Shebalin, V; Shen, C P; Shibata, T -A; Shiu, J -G; Sibidanov, A; Sohn, Y -S; Solovieva, E; Stanič, S; Starič, M; Steder, M; Sumihama, M; Sumiyoshi, T; Tamponi, U; Tanida, K; Teramoto, Y; Trabelsi, K; Uchida, M; Uehara, S; Uglov, T; Uno, S; Van Hulse, C; Vanhoefer, P; Varner, G; Varvell, K E; Vinokurova, A; Wagner, M N; Wang, C H; Wang, P; Watanabe, M; Watanabe, Y; Williams, K M; Yamashita, Y; Yashchenko, S; Yook, Y; Yuan, C Z; Zhilich, V; Zhulanov, V; Zupanc, A

    2014-01-01

    We present measurements of the masses and decay widths of the baryonic states $\\Sigma_{c}(2455)^{0/++}$ and $\\Sigma_{c}(2520)^{0/++}$ using a data sample corresponding to an integrated luminosity of 711 fb$^{-1}$ collected with the Belle detector at the KEKB $e^{+}e^{-}$ asymmetric-energy collider operating at the $\\Upsilon(4S)$ resonance. We report the mass differences with respect to the $\\Lambda_{c}^{+}$ baryon $M(\\Sigma_{c}(2455)^{0})-M(\\Lambda_{c}^{+}) = 167.29\\pm0.01\\pm0.02$ MeV/$c^{2}$, $M(\\Sigma_{c}(2455)^{++})-M(\\Lambda_{c}^{+}) = 167.51\\pm0.01\\pm0.02$ MeV/$c^{2}$, $M(\\Sigma_{c}(2520)^{0})-M(\\Lambda_{c}^{+}) = 231.98\\pm0.11\\pm0.04$ MeV/$c^{2}$, $M(\\Sigma_{c}(2520)^{++})-M(\\Lambda_{c}^{+}) = 231.99\\pm0.10\\pm0.02$ MeV/$c^{2}$, and the decay widths $\\Gamma(\\Sigma_{c}(2455)^{0}) = 1.76\\pm0.04^{+0.09}_{-0.21}$ MeV/$c^{2}$, $\\Gamma(\\Sigma_{c}(2455)^{++}) = 1.84\\pm0.04^{+0.07}_{-0.20}$ MeV/$c^{2}$, $\\Gamma(\\Sigma_{c}(2520)^{0}) = 15.41\\pm0.41^{+0.20}_{-0.32}$ MeV/$c^{2}$, $\\Gamma(\\Sigma_{c}(2520)^{++}) = 14...

  10. Propionibacterium acnes biofilm - A sanctuary for Staphylococcus aureus?

    Science.gov (United States)

    Tyner, Harmony; Patel, Robin

    2016-08-01

    The purpose of this study was to measure the effect of combined culture of Propionibacterium acnes and Staphylococcus aureus on biofilm formation under different oxygen concentrations. We measured planktonic growth and biofilm formation of P. acnes and S. aureus alone and together under aerobic and anaerobic conditions. Both P. acnes and S. aureus grew under anaerobic conditions. When grown under anaerobic conditions, P. acnes with or without S. aureus formed a denser biomass biofilm than did S. aureus alone. Viable S. aureus was recovered from a16-day old combined P. acnes and S. aureus biofilm, but not a monomicrobial S. aureus biofilm.

  11. Evolution of methicillin-resistant Staphylococcus aureus towards increasing resistance

    DEFF Research Database (Denmark)

    Strommenger, Birgit; Bartels, Mette Damkjær; Kurt, Kevin

    2014-01-01

    To elucidate the evolutionary history of Staphylococcus aureus clonal complex (CC) 8, which encompasses several globally distributed epidemic lineages, including hospital-associated methicillin-resistant S. aureus (MRSA) and the highly prevalent community-associated MRSA clone USA300....

  12. Reconstruction and topological characterization of the sigma factor regulatory network of Mycobacterium tuberculosis.

    Science.gov (United States)

    Chauhan, Rinki; Ravi, Janani; Datta, Pratik; Chen, Tianlong; Schnappinger, Dirk; Bassler, Kevin E; Balázsi, Gábor; Gennaro, Maria Laura

    2016-03-31

    Accessory sigma factors, which reprogram RNA polymerase to transcribe specific gene sets, activate bacterial adaptive responses to noxious environments. Here we reconstruct the complete sigma factor regulatory network of the human pathogen Mycobacterium tuberculosis by an integrated approach. The approach combines identification of direct regulatory interactions between M. tuberculosis sigma factors in an E. coli model system, validation of selected links in M. tuberculosis, and extensive literature review. The resulting network comprises 41 direct interactions among all 13 sigma factors. Analysis of network topology reveals (i) a three-tiered hierarchy initiating at master regulators, (ii) high connectivity and (iii) distinct communities containing multiple sigma factors. These topological features are likely associated with multi-layer signal processing and specialized stress responses involving multiple sigma factors. Moreover, the identification of overrepresented network motifs, such as autoregulation and coregulation of sigma and anti-sigma factor pairs, provides structural information that is relevant for studies of network dynamics.

  13. Mastite com lesões sistêmicas por Staphylococus aureus subesp. aureus em coelhos Mastitis with systemic lesions due to Staphylococus aureus subesp. aureus in rabbits

    Directory of Open Access Journals (Sweden)

    Sandra Davi Traverso

    2003-04-01

    Full Text Available Em uma criação composta por 1800 coelhos, 33% das matrizes apresentaram mastite e lesões cutâneas crostosas e purulentas. Estes animais apresentavam-se entre 10 a- 12 meses de idade e em segunda parição. Quinze coelhos afetados foram sacrificados e necropsiados. Na necropsia, além das lesões cutâneas haviam microabscessos em diversos órgãos. Das amostras coletadas isolou-se Staphylococcus aureus subesp. aureus. S. aureus subesp. aureus também foi isolado de "swab" nasal coletado do tratador encarregado de fazer o diagnóstico de gestação nas coelhas. Histologicamente, havia formação de múltiplos abscessos, presença de bactérias gram positivas em vasos sangüíneos e linfáticos, além de êmbolos bacterianos nos tecidos. Nas mamas, observou-se tecido glandular normal associado a abscessos multifocais delimitados.At a commercial rabbitry which was composed of 1800 New Zealand White rabbits, 30% of the does had presented mastitis and purulent cutaneal lesions. The age of the animals ranged from 10 to 12 months and were at the second parturition. At necropsy, microabscesses were observed in several organs. Bacteriological samples collected from affected animals resulted Staphylococcus aureus subesp. aureus.. Additionally, the same agent has been isolated from a nasal swab collected from the person responsible for the pregnancy diagnosis. Histologically, there were multiple abscesses, gram positive bacteria within blood and lymphatic vessels, and bacterial emboli scattered in the tissues. In the mammas, normal glandular tissue associated with multifocal abscesses were observed.

  14. Epidemiology of Staphylococcus aureus during space flight

    Science.gov (United States)

    Pierson, D. L.; Chidambaram, M.; Heath, J. D.; Mallary, L.; Mishra, S. K.; Sharma, B.; Weinstock, G. M.

    1996-01-01

    Staphylococcus aureus was isolated over 2 years from Space Shuttle mission crewmembers to determine dissemination and retention of bacteria. Samples before and after each mission were from nasal, throat, urine, and feces and from air and surface sampling of the Space Shuttle. DNA fingerprinting of samples by digestion of DNA with SmaI restriction endonuclease followed by pulsed-field gel electrophoresis showed S. aureus from each crewmember had a unique fingerprint and usually only one strain was carried by an individual. There was only one instance of transfer between crewmembers. Strains from interior surfaces after flight matched those of crewmembers, suggesting microbial fingerprinting may have forensic application.

  15. Design and Research on Sigma-Delta Digital-to-Analog Converters for Audio Power Amplifiers

    OpenAIRE

    Puidokas, Vytenis

    2011-01-01

    The dissertation investigates the issues of analyzing a digital Sigma-Delta digital-to-analog converter (DAC) for audio power amplifiers. The main objects of research include a digital Sigma-Delta audio power DAC, improvement of its structure and an experimental research. The primary purpose of the dissertation is to suggest methods for improvement the structure of digital Sigma-Delta audio power DAC interpolator and the converter analysis. Disertacijoje nagrinėjami Sigma-Delta skaitmenini...

  16. The structural basis for promoter -35 element recognition by the group IV sigma factors.

    OpenAIRE

    William J Lane; Darst, Seth A.

    2006-01-01

    The control of bacterial transcription initiation depends on a primary sigma factor for housekeeping functions, as well as alternative sigma factors that control regulons in response to environmental stresses. The largest and most diverse subgroup of alternative sigma factors, the group IV extracytoplasmic function sigma factors, directs the transcription of genes that regulate a wide variety of responses, including envelope stress and pathogenesis. We determined the 2.3-A resolution crystal ...

  17. The molecular evolution of methicillin-resistant Staphylococcus aureus

    NARCIS (Netherlands)

    Deurenberg, R H; Vink, C; Kalenic, S; Friedrich, A W; Bruggeman, C A; Stobberingh, E E

    2007-01-01

    Staphylococcus aureus is a potentially pathogenic bacterium that causes a broad spectrum of diseases. S. aureus can adapt rapidly to the selective pressure of antibiotics, and this has resulted in the emergence and spread of methicillin-resistant S. aureus (MRSA). Resistance to methicillin and other

  18. 9 CFR 113.115 - Staphylococcus Aureus Bacterin-Toxoid.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Staphylococcus Aureus Bacterin-Toxoid... REQUIREMENTS Inactivated Bacterial Products § 113.115 Staphylococcus Aureus Bacterin-Toxoid. Staphylococcus... Staphylococcus aureus which has been inactivated and is nontoxic. Each serial of biological product...

  19. A pig model of acute Staphylococcus aureus induced pyemia

    DEFF Research Database (Denmark)

    Nielsen, O. L.; Iburg, T.; Aalbæk, B.;

    2009-01-01

    Background: Sepsis caused by Staphylococcus aureus constitutes an important cause of morbidity and mortality in humans, and the incidence of this disease-entity is increasing. In this paper we describe the initial microbial dynamics and lesions in pigs experimentally infected with S. aureus....... aureus isolated from man and an extension of the timeframe aiming at inducing sepsis, severe sepsis and septic shock....

  20. A Framework for Six Sigma Project Selection in Higher Educational Institutions, Using a Weighted Scorecard Approach

    Science.gov (United States)

    Holmes, Monica C.; Jenicke, Lawrence O.; Hempel, Jessica L.

    2015-01-01

    Purpose: This paper discusses the importance of the Six Sigma selection process, describes a Six Sigma project in a higher educational institution and presents a weighted scorecard approach for project selection. Design/Methodology/Approach: A case study of the Six Sigma approach being used to improve student support at a university computer help…

  1. Cutamesine Overcomes REM Sleep Deprivation-Induced Memory Loss : Relationship to Sigma-1 Receptor Occupancy

    NARCIS (Netherlands)

    Kuzhuppilly Ramakrishnan, Nisha; Schepers, Marianne; Luurtsema, Gert; Nyakas, Csaba J.; Elsinga, Philip H.; Ishiwata, Kiichi; Dierckx, Rudi A. J. O.; van Waarde, Aren

    2015-01-01

    Rapid eye movement (REM) sleep deprivation (SD) decreases cerebral sigma-1 receptor expression and causes cognitive deficits. Sigma-1 agonists are cognitive enhancers. Here, we investigate the effect of cutamesine treatment in the REM SD model. Sigma-1 receptor occupancy (RO) in the rat brain by cut

  2. MTDH mediates trastuzumab resistance in HER2 positive breast cancer by decreasing PTEN expression through an NFκB-dependent pathway

    OpenAIRE

    Du, Cheng; Yi, Xiaomin; Liu, Wenchao; Han, Tao; Liu,Zhaozhe; Ding, Zhenyu; Zheng, Zhendong; PIAO, YING; Yuan, Jianlin; Han, Yaling; Xie, Manjiang; Xie, Xiaodong

    2014-01-01

    Background Trastuzumab resistance is almost inevitable in the management of human epidermal growth factor receptor (HER) 2 positive breast cancer, in which phosphatase and tensin homolog deleted from chromosome 10 (PTEN) loss is implicated. Since metadherin (MTDH) promotes malignant phenotype of breast cancer, we sought to define whether MTDH promotes trastuzumab resistance by decreasing PTEN expression through an NFκB-dependent pathway. Methods The correlations between MTDH and PTEN expressi...

  3. The New $\\sigma_{tot}(\\Sigma p)$ Data, the new PDG fit to hadron total cross sections and the TCP alternative

    CERN Document Server

    Lipkin, Harry Jeannot

    1999-01-01

    The new SELEX measurement $\\sigma_{tot}(\\Sigma p) = 36.96 \\pm 0.65$ at P = 609 GeV/c and the new 1998 Particle-Data-Group Regge (PDG) analysis of hadron total cross sections with an additional even-signature-exchange contribution recall the 1975 two-component-Pomeron model (TCP), which introduced such an additional term and predicted $\\sigma_{tot}(\\Sigma p) = 37.07$ mb. in 1975 as well as fitting all the same data now fit by PDG with fewer free parameters.and predicting $\\sigma_{tot}(\\Sigma p)$, (not predicted by PDG) at lower energies. The additional contribution confuses the extraction of the Pomeron intercept from data in the 600 GeV range and its dynamical origin is still unclear. But its surprising systematics suggests an interesting origin.

  4. Staphylococcus aureus entrance into the dairy chain: Tracking S. aureus from dairy cow to cheese

    Directory of Open Access Journals (Sweden)

    Judith Kümmel

    2016-10-01

    Full Text Available Staphylococcus aureus is one of the most important contagious mastitis pathogens in dairy cattle. Due to its zoonotic potential, control of S. aureus is not only of great economic importance in the dairy industry but also a significant public health concern. The aim of this study was to decipher the potential of bovine udder associated S. aureus as reservoir for S. aureus contamination in dairy production and processing. From 18 farms, delivering their milk to an alpine dairy plant for the production of smeared semi-hard and hard cheese. 1176 quarter milk (QM samples of all cows in lactation (n = 294 and representative samples form bulk tank milk (BTM of all farms were surveyed for coagulase positive (CPS and coagulase negative Staphylococci (CNS. Furthermore, samples from different steps of the cheese manufacturing process were tested for CPS and CNS. As revealed by chemometric-assisted FTIR spectroscopy and molecular subtyping (spa typing and multi locus sequence typing, dairy cattle represent indeed an important, yet underreported, entrance point of S. aureus into the dairy chain. Our data clearly show that certain S. aureus subtypes are present in primary production as well as in the cheese processing at the dairy plant. However, although a considerable diversity of S. aureus subtypes was observed in QM and BTM at the farms, only certain S. aureus subtypes were able to enter and persist in the cheese manufacturing at the dairy plant and could be isolated from cheese until day fourteen of ripening. Farm strains belonging to the FTIR cluster B1 and B3, which show genetic characteristics (t2953, ST8, enterotoxin profile: sea/sed/sej of the recently described S. aureus genotype B, most successfully contaminated the cheese production at the dairy plant. Thus our study fosters the hypothesis that genotype B S. aureus represent a specific challenge in control of S. aureus in the dairy chain that requires effective clearance strategies and hygienic

  5. Staphylococcus aureus Entrance into the Dairy Chain: Tracking S. aureus from Dairy Cow to Cheese

    Science.gov (United States)

    Kümmel, Judith; Stessl, Beatrix; Gonano, Monika; Walcher, Georg; Bereuter, Othmar; Fricker, Martina; Grunert, Tom; Wagner, Martin; Ehling-Schulz, Monika

    2016-01-01

    Staphylococcus aureus is one of the most important contagious mastitis pathogens in dairy cattle. Due to its zoonotic potential, control of S. aureus is not only of great economic importance in the dairy industry but also a significant public health concern. The aim of this study was to decipher the potential of bovine udder associated S. aureus as reservoir for S. aureus contamination in dairy production and processing. From 18 farms, delivering their milk to an alpine dairy plant for the production of smeared semi-hard and hard cheese. one thousand hundred seventy six one thousand hundred seventy six quarter milk (QM) samples of all cows in lactation (n = 294) and representative samples form bulk tank milk (BTM) of all farms were surveyed for coagulase positive (CPS) and coagulase negative Staphylococci (CNS). Furthermore, samples from different steps of the cheese manufacturing process were tested for CPS and CNS. As revealed by chemometric-assisted FTIR spectroscopy and molecular subtyping (spa typing and multi locus sequence typing), dairy cattle represent indeed an important, yet underreported, entrance point of S. aureus into the dairy chain. Our data clearly show that certain S. aureus subtypes are present in primary production as well as in the cheese processing at the dairy plant. However, although a considerable diversity of S. aureus subtypes was observed in QM and BTM at the farms, only certain S. aureus subtypes were able to enter and persist in the cheese manufacturing at the dairy plant and could be isolated from cheese until day 14 of ripening. Farm strains belonging to the FTIR cluster B1 and B3, which show genetic characteristics (t2953, ST8, enterotoxin profile: sea/sed/sej) of the recently described S. aureus genotype B, most successfully contaminated the cheese production at the dairy plant. Thus, our study fosters the hypothesis that genotype B S. aureus represent a specific challenge in control of S. aureus in the dairy chain that requires

  6. Meningitis causada por staphylococcus aureus catalasa negativa

    OpenAIRE

    Álvarez Moreno, Carlos Arturo; Arroyo A., Claudia Patricia; Rodríguez, Elizabeth; Martínez R., Luz Marina; Quevedo S., Ruth

    2011-01-01

    En un paciente con cáncer se aisló del liquido cefaloraquideo y ascitico un coco gram positivo coagulasa positivo. El germen aislado mostró las características típicas de un Staphylococcus aureus, a excepción de la actividad de la catalasa, la cual no pudo ser encontrada.

  7. Staphylococcus aureus spa type t437

    DEFF Research Database (Denmark)

    Glasner, C; Pluister, G; Westh, H;

    2015-01-01

    Methicillin-resistant Staphylococcus aureus (MRSA) belonging to the multilocus sequence type clonal complex 59 (MLST CC59) is the predominant community-associated MRSA clone in Asia. This clone, which is primarily linked with the spa type t437, has so far only been reported in low numbers among...

  8. Meticillin-resistant Staphylococcus aureus (MRSA)

    DEFF Research Database (Denmark)

    Stefani, Stefania; Chung, Doo Ryeon; Lindsay, Jodi A;

    2012-01-01

    This article reviews recent findings on the global epidemiology of healthcare-acquired/associated (HA), community-acquired/associated (CA) and livestock-associated (LA) meticillin-resistant Staphylococcus aureus (MRSA) and aims to reach a consensus regarding the harmonisation of typing methods...

  9. Methicillin-resistant Staphylococcus aureus transmission

    DEFF Research Database (Denmark)

    Andersen, Leif Percival; Nielsen, Xiaohui

    2015-01-01

    INTRODUCTION: Even though methicillin-resistant Staphylococcus aureus (MRSA) is a common cause of nosocomial infections, it may often be difficult to evaluate the exact route of transmission. METHODS: In this study, we describe four cases of nosocomial transmission of MRSA in a hospital with a low...

  10. Profiling the surfacome of Staphylococcus aureus

    NARCIS (Netherlands)

    Dreisbach, Annette; Hempel, Kristina; Buist, Girbe; Hecker, Michael; Becher, Doerte; van Dijl, Jan Maarten

    2010-01-01

    Staphylococcus aureus is a widespread opportunistic pathogen that can cause a wide variety of life-threatening diseases. Especially for the colonization of human tissues and the development of invasiveness, surface-exposed proteins are of major importance. In the present studies, we optimized a prot

  11. Staphylococcus aureus resistente a la meticilina (SARM)

    Centers for Disease Control (CDC) Podcasts

    2007-10-22

    Datos importantes sobre las infecciones por SARM en Estados Unidos, en las escuelas y los entornos médicos. (Title: Methicillin-resistant Staphylococcus aureus (MRSA)Created: 10/2007).  Created: 10/22/2007 by National Center for Preparedness, Detection, and Control of Infectious Diseases.   Date Released: 11/9/2007.

  12. An extracytoplasmic function sigma factor-mediated cell surface signaling system in Pseudomonas syringae pv. tomato DC3000 regulates gene expression in response to heterologous siderophores.

    Science.gov (United States)

    Markel, Eric; Maciak, Charlene; Butcher, Bronwyn G; Myers, Christopher R; Stodghill, Paul; Bao, Zhongmeng; Cartinhour, Sam; Swingle, Bryan

    2011-10-01

    The diversity of regulatory systems encoded by bacteria provides an indication of the variety of stresses and interactions that these organisms encounter in nature. We have been investigating how the plant pathogen Pseudomonas syringae pv. tomato DC3000 responds to iron limitation and have focused on the iron starvation (IS) sigma factors to identify regulon members and to explore the mechanistic details of genetic control for this class of regulators. In the study described in this report, we used chromatin immunoprecipitation paired with high-throughput sequencing (ChIP-Seq) to screen the genome for locations associated with binding of the P. syringae IS sigma factor PSPTO_1203. We used multiple methods to demonstrate differential regulation of two genes identified in the ChIP-Seq screen and characterize the promoter elements that facilitate PSPTO_1203-dependent regulation. The genes regulated by PSPTO_1203 encode a TonB-dependent transducer (PSPTO_1206) and a cytoplasmic membrane protein (PSPTO_2145), which is located in the P. syringae pyoverdine cluster. Additionally, we identified siderophores that induce the activity of PSPTO_1203 and used this information to investigate the functional components of the signal transduction cascade.

  13. IMPROVE MACHINING PROCESS CAPABILITY BY USING SIX-SIGMA

    Directory of Open Access Journals (Sweden)

    Sanjit Ray

    2011-06-01

    Full Text Available Abstract: Six-Sigma is an improvement strategy for achieving customer satisfaction by reducing variation and thus producing products and services better, faster and cheaper. This study presents a Six-Sigma project of an automotive plant illustrating how the DMAIC methodology and statistical techniques were applied to resolve the issue of manufacturing process capability. This project has substantially benefit ted the organization by reducing the variation of bore size of crank case, achieving zero rejection and improving the on time delivery. By using appropriate qualitative and quantitative tools in different phases of the DMAIC methodology, the critical output, key process inputs and root causes were identified, analyzed and validated. This project methodology can be used in general to reduce process variation for any other manufacturing processes as well, which will help in improving customer satisfaction.

  14. Rethinking behavioral health processes by using design for six sigma.

    Science.gov (United States)

    Lucas, Anthony G; Primus, Kelly; Kovach, Jamison V; Fredendall, Lawrence D

    2015-02-01

    Clinical evidence-based practices are strongly encouraged and commonly utilized in the behavioral health community. However, evidence-based practices that are related to quality improvement processes, such as Design for Six Sigma, are often not used in behavioral health care. This column describes the unique partnership formed between a behavioral health care provider in the greater Pittsburgh area, a nonprofit oversight and monitoring agency for behavioral health services, and academic researchers. The authors detail how the partnership used the multistep process outlined in Design for Six Sigma to completely redesign the provider's intake process. Implementation of the redesigned process increased access to care, decreased bad debt and uncollected funds, and improved cash flow--while consumer satisfaction remained high.

  15. Optimization of Steel Bar Manufacturing Process Using Six Sigma

    Institute of Scientific and Technical Information of China (English)

    NAEEM Khawar; ULLAH Misbah; TARIQ Adnan; MAQSOOD Shahid; AKHTAR Rehman; NAWAZ Rashid; HUSSAIN Iftikhar

    2016-01-01

    Optimization of a manufacturing process results in higher productivity and reduced wastes. Production parameters of a local steel bar manufacturing industry of Pakistan is optimized by using six Sigma-Define, measure, analyze, improve, and control- methodology. Production data is collected and analyzed. After analysis, experimental design result is used to identify significant factors affecting process performance. The significant factors are controlled to optimized level using two-level factorial design method. A regression model is developed that helps in the estimation of response under multi variable input values. Model is tested, verified, and validated by using industrial data collected at a local steel bar manufacturing industry of Peshawar(Khyber Pakhtunkhwa, Pakistan). The sigma level of the manufacturing process is improved to 4.01 from 3.58. The novelty of the research is the identification of the significant factors along with the optimum levels that affects the process yield, and the methodology to optimize the steel bar manufacturing process.

  16. Optimization of steel bar manufacturing process using six sigma

    Science.gov (United States)

    Naeem, Khawar; Ullah, Misbah; Tariq, Adnan; Maqsood, Shahid; Akhtar, Rehman; Nawaz, Rashid; Hussain, Iftikhar

    2016-03-01

    Optimization of a manufacturing process results in higher productivity and reduced wastes. Production parameters of a local steel bar manufacturing industry of Pakistan is optimized by using six Sigma-Define, measure, analyze, improve, and controlmethodology. Production data is collected and analyzed. After analysis, experimental design result is used to identify significant factors affecting process performance. The significant factors are controlled to optimized level using two-level factorial design method. A regression model is developed that helps in the estimation of response under multi variable input values. Model is tested, verified, and validated by using industrial data collected at a local steel bar manufacturing industry of Peshawar(Khyber Pakhtunkhwa, Pakistan). The sigma level of the manufacturing process is improved to 4.01 from 3.58. The novelty of the research is the identification of the significant factors along with the optimum levels that affects the process yield, and the methodology to optimize the steel bar manufacturing process.

  17. Multi-Agent Modeling in Managing Six Sigma Projects

    Directory of Open Access Journals (Sweden)

    K. Y. Chau

    2009-10-01

    Full Text Available In this paper, a multi-agent model is proposed for considering the human resources factor in decision making in relation to the six sigma project. The proposed multi-agent system is expected to increase the acccuracy of project prioritization and to stabilize the human resources service level. A simulation of the proposed multiagent model is conducted. The results show that a multi-agent model which takes into consideration human resources when making decisions about project selection and project team formation is important in enabling efficient and effective project management. The multi-agent modeling approach provides an alternative approach for improving communication and the autonomy of six sigma projects in business organizations.

  18. LEAN AND SIX SIGMA CONCEPTS - APPLICATION IN PHARMACEUTICAL INDUSTRY

    Directory of Open Access Journals (Sweden)

    Katarina Pavlović

    2011-06-01

    Full Text Available LEAN thinking and Six Sigma have been utilized by manufacturing industries to decrease cost and improve quality and productivity by reducing variation and production defects. Because of the dramatic successes in manufacturing, there is rising interest among companies in the pharmaceutical industry, which choose to implement LEAN in order to accomplish such goals as decreased wait time to release product to the market, reduce production waste, improve communication with end users and raise quality level both in the production and in testing laboratories. In this article, basics of LEAN and Six Sigma are presented and suggestion was given for application of their concepts in pharmaceutical industry together with harmonization with legal regulation represented by requirements Good Manufacturing Practice (cGMP, in order to work "smarter", more cost- effectively and avoid wasting time and other resources.

  19. LEAN AND SIX SIGMA CONCEPTS APPLICATION IN PHARMACEUTICAL INDUSTRY

    Directory of Open Access Journals (Sweden)

    Katarina Pavlović

    2012-03-01

    Full Text Available LEAN thinking and Six Sigma have been utilized by manufacturing industries to decrease cost and improve quality and productivity by reducing variation and production defects [1]. Because of the dramatic successes in manufacturing, there is rising interest among companies in the pharmaceutical industry, which chooses to implement LEAN in order to accomplish such goals as decreased wait time to release product to the market, reduce production waste, and improve communication with end users and raize quality level both in the production and in testing laboratories. In this article, basics of LEAN and Six Sigma are presented and suggestion was given for application of their concepts in pharmaceutical industry together with harmonization with legal regulation represented by requirements Good Manufacturing Practice (cGMP, in order to work "smarter", more cost-effectively and avoid was ting time and other resources.

  20. DEVELOPMENT OF SIX SIGMA INFRASTRUCTURE FOR STRABISMUS SURGERIES

    Directory of Open Access Journals (Sweden)

    Mehmet Tolga Taner

    2014-01-01

    Full Text Available The purpose of this study is to show how a private eye care center in Turkey developed a Six Sigma infrastructure to investigate the root causes of complications occuring during strabismus surgeries. To analyze the collected data, main tools of Six Sigma’s Define-Measure-Analyze-Improve-Control (DMAIC improvement cycle such as SIPOC table, Fishbone Diagram and, Failure, Mode and Effect Analysis were implemented. Patient’s eye anatomy, experience of the anesthesiologist, experience/attention of the strabismus surgeon was identified to be Critical-to-Quality (CTQ factors for a successful strabismus surgery. The most frequent complications of strabismus surgeries were found to be X, Y and Z. The process sigma level was found to be 3.2025.

  1. Effective action and vacuum expectations in nonlinear $\\sigma$ model

    CERN Document Server

    Fayzullaev, B A

    2015-01-01

    The equations for effective action for nonlinear $\\sigma$ model are derived using DeWitt method in two forms - for generator of vertex parts $\\Gamma$ and for generator of weakly connected parts $W$. Loop-expansion solutions to these equations are found. It is shown that vacuum expectation values for various quantities including divergence of a N\\"{o}ther current, trace of the energy-momentum tensor and so on, can be calculated by this method. Also it is shown that vacuum expectation to the sigma-field is determined by an explicit combination of tree Green function and classical solution. It is shown that the limit when coupling constant tends to zero is singular one.

  2. On energy conversion in a sigma coordinate ocean model

    Energy Technology Data Exchange (ETDEWEB)

    Eldevik, Tor

    1999-08-01

    Energy diagnostics are useful for understanding the transfer of energy through instabilities and between different scales. In this note the conservation equations for kinetic and potential energy, divided into suitable mean and eddy quantities, for a sigma coordinate ocean model are set up. By identifying the transfer terms responsible for the conservative conversions between the different energies, an energy flow diagram is suggested. The motivation for this is twofold. Firstly, the average operator required for dividing the quantities of the flow into mean and eddy parts is in general not well defined in Cartesian coordinates when the upper and lower boundaries are not at fixed vertical levels. This is overcome by introducing the ''terrain-following'' sigma as the vertical coordinate. Secondly, and most important, many of today's numerical ocean models have this as the vertical coordinate. (author)

  3. $\\sigma$-Set Theory and the Integer Space

    CERN Document Server

    Araus, Ivan Gatica

    2009-01-01

    In this article we develop an alternative theory to the ZF Set Theory called $\\sigma$-Set Theory. The goal of this theory is to build the Integer Space $3^{X}$, that will be the algebraic completion of the Power Set $2^{X}$, i.e., $3^{X}$ contains the inverse element for the union, that in this case we call fusion. We first give an introduction where we explain in a more detailed way the motivations and the objectives of this new theory. Later we present the language of the theory that will be the same as that of the Set Theory. Finally, we present the axioms of the $\\sigma$-Set Theory and their individual analysis.

  4. Adaptive Delta-Sigma Modulation for Enhanced Input Dynamic Range

    Directory of Open Access Journals (Sweden)

    Clemens M. Zierhofer

    2008-06-01

    Full Text Available An adaptive delta-sigma modulator of 1st order with one-bit quantization is presented. Adaptation is instantaneous and based on an exponential law. The feedback signal is a multibit discrete-level signal generated by a digital-to-analog converter (DAC. Compared to a nonadaptive delta-sigma modulator of 1st order, the input dynamic range is significantly enhanced. The gain in dynamic range is 6 dB per bit defining the feedback amplitude. The influence of nonideal DAC performance is discussed. It is demonstrated that an implementation of the system is realistic with standard CMOS technology. To relax the requirements to the one-bit quantizer, the quantizer input signal is amplified adaptively (Q-Switching.

  5. Six sigma for organizational excellence a statistical approach

    CERN Document Server

    Muralidharan, K

    2015-01-01

    This book discusses the integrated concepts of statistical quality engineering and management tools. It will help readers to understand and apply the concepts of quality through project management and technical analysis, using statistical methods. Prepared in a ready-to-use form, the text will equip practitioners to implement the Six Sigma principles in projects. The concepts discussed are all critically assessed and explained, allowing them to be practically applied in managerial decision-making, and in each chapter, the objectives and connections to the rest of the work are clearly illustrated. To aid in understanding, the book includes a wealth of tables, graphs, descriptions and checklists, as well as charts and plots, worked-out examples and exercises. Perhaps the most unique feature of the book is its approach, using statistical tools, to explain the science behind Six Sigma project management and integrated in engineering concepts. The material on quality engineering and statistical management tools of...

  6. Off-shell BCJ Relation in Nonlinear Sigma Model

    CERN Document Server

    Chen, Gang; Liu, Hanqing

    2016-01-01

    We investigate relations among tree-level off-shell currents in nonlinear sigma model. Under Cayley parametrization, we propose and prove a general revised BCJ relation for even-point currents. Unlike the on-shell BCJ relation, the off-shell one behaves quite differently from Yang-Mills theory although the algebraic structure is the same. After performing the permutation summation in the revised BCJ relation, the sum is non-vanishing, instead, it equals to the sum of sub-current products with the BCJ coefficients under a specific ordering, which is presented by an explicit formula. Taking on-shell limit, this identity is reduced to the on-shell BCJ relation, and thus provides the full off-shell correspondence of tree-level BCJ relation in nonlinear sigma model.

  7. Lepton Private Higgs and the discrete group \\Sigma(81)

    CERN Document Server

    BenTov, Yoni

    2012-01-01

    We use the discrete group \\Sigma(81) = (Z_3 x Z_3 x Z_3)\\rx Z_3 to suggest a relation among the off-diagonal entries of the neutrino mass matrix, as well as to explain the muon magnetic moment anomaly, a_\\mu^exp-a_\\mu^SM ~ 10^{-9}. We predict three new nearly degenerate Higgs doublets with masses of order ~500 GeV to ~ 1 TeV, and three nearly degenerate SM-singlet TeV-scale neutrinos. The largest scale in the model is ~10 TeV, so there is no severe hierarchy problem. The appendix is devoted to the group theory of \\Sigma(81).

  8. Applying a Hybrid MCDM Model for Six Sigma Project Selection

    Directory of Open Access Journals (Sweden)

    Fu-Kwun Wang

    2014-01-01

    Full Text Available Six Sigma is a project-driven methodology; the projects that provide the maximum financial benefits and other impacts to the organization must be prioritized. Project selection (PS is a type of multiple criteria decision making (MCDM problem. In this study, we present a hybrid MCDM model combining the decision-making trial and evaluation laboratory (DEMATEL technique, analytic network process (ANP, and the VIKOR method to evaluate and improve Six Sigma projects for reducing performance gaps in each criterion and dimension. We consider the film printing industry of Taiwan as an empirical case. The results show that our study not only can use the best project selection, but can also be used to analyze the gaps between existing performance values and aspiration levels for improving the gaps in each dimension and criterion based on the influential network relation map.

  9. Sigma-1 Receptor Modulates Neuroinflammation After Traumatic Brain Injury.

    Science.gov (United States)

    Dong, Hui; Ma, Yunfu; Ren, Zengxi; Xu, Bin; Zhang, Yunhe; Chen, Jing; Yang, Bo

    2016-07-01

    Traumatic brain injury (TBI) remains a significant clinical problem and contributes to one-third of all injury-related deaths. Activated microglia-mediated inflammatory response is a distinct characteristic underlying pathophysiology of TBI. Here, we evaluated the effect and possible mechanisms of the selective Sigma-1 receptor agonist 2-(4-morpholinethyl)-1-phenylcyclohexanecarboxylate (PRE-084) in mice TBI model. A single intraperitoneal injection 10 μg/g PRE-084, given 15 min after TBI significantly reduced lesion volume, lessened brain edema, attenuated modified neurological severity score, increased the latency time in wire hang test, and accelerated body weight recovery. Moreover, immunohistochemical analysis with Iba1 staining showed that PRE-084 lessened microglia activation. Meanwhile, PRE-084 reduced nitrosative and oxidative stress to proteins. Thus, Sigma-1 receptors play a major role in inflammatory response after TBI and may serve as useful target for TBI treatment in the future.

  10. Nonlinear Sigma Models with Compact Hyperbolic Target Spaces

    CERN Document Server

    Gubser, Steven; Schoenholz, Samuel S; Stoica, Bogdan; Stokes, James

    2015-01-01

    We explore the phase structure of nonlinear sigma models with target spaces corresponding to compact quotients of hyperbolic space, focusing on the case of a hyperbolic genus-2 Riemann surface. The continuum theory of these models can be approximated by a lattice spin system which we simulate using Monte Carlo methods. The target space possesses interesting geometric and topological properties which are reflected in novel features of the sigma model. In particular, we observe a topological phase transition at a critical temperature, above which vortices proliferate, reminiscent of the Kosterlitz-Thouless phase transition in the $O(2)$ model. Unlike in the $O(2)$ case, there are many different types of vortices, suggesting a possible analogy to the Hagedorn treatment of statistical mechanics of a proliferating number of hadron species. Below the critical temperature the spins cluster around six special points in the target space known as Weierstrass points. The diversity of compact hyperbolic manifolds suggest...

  11. Sigma, Kappa, fo(980) and a0(980)

    CERN Document Server

    Bugg, D V

    2005-01-01

    Both sigma and kappa are well established from E791 data on D->3pi and Ds->Kpipi and BES II data on J/Psi -> omega pi pi and KKpipi. These fits are accurately consistent with pipi and Kpi elastic scattering when one allows for the Adler zero which arises from Chiral Symmetry Breaking. The phase variation with mass is consistent between elastic scattering and production data. Possible interpretations of sigma, kappa, fo(980) and ao(980) are explored. The experimental ratio g^2(fo(980)->KK)/g^2(ao(980)->KK) = 2.7+-0.5 suggests strongly that fo(980) has a large KK component in its wave function. This is a natural consequence of its pole lying very close to the KK threshold.

  12. T^{\\sigma}_{\\rho}(G) Theories and Their Hilbert Series

    CERN Document Server

    Cremonesi, Stefano; Mekareeya, Noppadol; Zaffaroni, Alberto

    2015-01-01

    We give an explicit formula for the Higgs and Coulomb branch Hilbert series for the class of 3d N=4 superconformal gauge theories T^{\\sigma}_{\\rho}(G) corresponding to a set of D3 branes ending on NS5 and D5-branes, with or without O3 planes. Here G is a classical group, \\sigma is a partition of G and \\rho a partition of the dual group G^\\vee. In deriving such a formula we make use of the recently discovered formula for the Hilbert series of the quantum Coulomb branch of N=4 superconformal theories. The result can be expressed in terms of a generalization of a class of symmetric functions, the Hall-Littlewood polynomials, and can be interpreted in mathematical language in terms of localization. We mainly consider the case G=SU(N) but some interesting results are also given for orthogonal and symplectic groups.

  13. Observation of the sigma_b baryons at CDF

    Energy Technology Data Exchange (ETDEWEB)

    Pursley, Jennifer M.; /Johns Hopkins U.

    2007-03-01

    We present a measurement of four new bottom baryons in proton-antiproton collisions with a center of mass energy of 1.96 TeV. Using 1.1 fb{sup -1} of data collected by the CDF II detector, we observe four {Lambda}{sup 0}{sub b}{pi}{+-} resonances in the fully reconstructed decay mode {Lambda}{sup 0}{sub b} {yields} {Lambda}{sup +}{sub c}{pi}{sup -}, where {Lambda}{sup +}{sub c} {yields} pK{sup -}{pi}{sup +}. The probability for the background to produce a similar or larger signal is less than 8.3 x 10{sup -8}, corresponding to a significance of greater than 5.2 {sigma}. We interpret these baryons as the {Sigma}{sub b}{sup (*){+-}} baryons.

  14. Generalized complex geometry, generalized branes and the Hitchin sigma model

    Energy Technology Data Exchange (ETDEWEB)

    Zucchini, Roberto E-mail: zucchinir@bo.infn.it

    2005-03-01

    Hitchin's generalized complex geometry has been shown to be relevant in compactifications of superstring theory with fluxes and is expected to lead to a deeper understanding of mirror symmetry. Gualtieri's notion of generalized complex submanifold seems to be a natural candidate for the description of branes in this context. Recently, we introduced a Batalin-Vilkovisky field theoretic realization of generalized complex geometry, the Hitchin sigma model, extending the well known Poisson sigma model. In this paper, exploiting Gualtieri's formalism, we incorporate branes into the model. A detailed study of the boundary conditions obeyed by the world sheet fields is provided. Finally, it is found that, when branes are present, the classical Batalin-Vilkovisky cohomology contains an extra sector that is related non trivially to a novel cohomology associated with the branes as generalized complex submanifolds. (author)

  15. Effects of the Tsallis distribution in the linear sigma model

    CERN Document Server

    Ishihara, Masamichi

    2014-01-01

    The effects of the Tsallis distribution which has a parameter $q$ on physical quantities are studied using the linear sigma model in chiral phase transitions. The temperature dependences of the condensate and mass for various $q$ are shown, where the Tsallis distribution approaches the Boltzmann-Gibbs distribution as $q$ approaches $1$. The critical temperature and energy density are described with digamma function, and the $q$ dependences of these quantities and the extension of Stefan-Boltzmann limit of the energy density are shown. The following facts are clarified. The chiral symmetry restoration for $q>1$ occurs at low temperature, compared with the restoration for $q=1$. The sigma mass and pion mass reflect the restoration. The critical temperature decreases monotonically as $q$ increases. The small deviation from the Boltzmann-Gibbs distribution results in the large deviations of physical quantities, especially the energy density. It is displayed from the energetic point of view that the small deviatio...

  16. DEPLOYMENT OF SIX SIGMA METHODOLOGY IN PHACOEMULSIFICATION CATARACT SURGERY

    Directory of Open Access Journals (Sweden)

    Ibrahim SAHBAZ

    2014-04-01

    Full Text Available The purpose of this study is to show how a public eye care center in Turkey initiated Six Sigma principles to reduce the number of complications encountered during and after phacoemulsification cataract surgeries. To analyze the 3-year data, main tools of Six Sigma’s Define-Measure-Analyze-Improve-Control (DMAIC improvement cycle such as SIPOC table, Fishbone Diagram and, Failure, Mode and Effect Analysis were implemented. Experience of the ophthalmic surgeon, patient’s anatomy, cooperation of patient during the surgery, sterilization and hygiene, attention of assistant surgeon, calibration of equipment and quality/chemical composition of intraocular material were identified to be Critical-to-Quality (CTQ factors for a successful phacoemulsification cataract surgery. The most frequently occurring complication was found to be iris atrophy. The process sigma level for the process was found to be 3.958.

  17. Making Supersymmetric Quivers from N =(0,2) Sigma Models

    CERN Document Server

    Shifman, Mikhail; Yung, Alexei

    2014-01-01

    We show how to construct quiver-like (0,2) sigma models starting from n copies of (2,2) CP(N-1) models (or similar more generic models). These "quivers" present a natural generalization of the non-minimally deformed (2,2) model with an extra (0,2) fermion superfield on tangle bundle T[CP(N-1)xC^1] considered previously. A remarkable feature observed is elimination of the spontaneous supersymmetry breaking. We study supersymmetric vacua and determine the particle spectrum in the large-N limit. We then examine the \\beta -functions of our quiver-like (0,2) sigma models and show that under certain conditions they develop an infrared fixed point in the perturbative domain.

  18. The coupling of Poisson sigma models to topological backgrounds

    CERN Document Server

    Rosa, Dario

    2016-01-01

    We extend the coupling to the topological backgrounds, recently worked out for the 2-dimensional BF-model, to the most general Poisson sigma models. The coupling involves the choice of a Casimir function on the target manifold and modifies the BRST transformations. This in turn induces a change in the BRST cohomology of the resulting theory. The observables of the coupled theory are analyzed and their geometrical intrepretation is given. We finally couple the theory to 2-dimensional topological gravity: this is the first step to study a topological string theory in propagation on a Poisson manifold. As an application, we show that the gauge-fixed vectorial supersymmetry of the Poisson sigma models has a natural explanation in terms of the theory coupled to topological gravity.

  19. Pseudo-random number generator for the Sigma 5 computer

    Science.gov (United States)

    Carroll, S. N.

    1983-01-01

    A technique is presented for developing a pseudo-random number generator based on the linear congruential form. The two numbers used for the generator are a prime number and a corresponding primitive root, where the prime is the largest prime number that can be accurately represented on a particular computer. The primitive root is selected by applying Marsaglia's lattice test. The technique presented was applied to write a random number program for the Sigma 5 computer. The new program, named S:RANDOM1, is judged to be superior to the older program named S:RANDOM. For applications requiring several independent random number generators, a table is included showing several acceptable primitive roots. The technique and programs described can be applied to any computer having word length different from that of the Sigma 5.

  20. Digital Pixel Sensor Array with Logarithmic Delta-Sigma Architecture

    Directory of Open Access Journals (Sweden)

    Jing Li

    2013-08-01

    Full Text Available Like the human eye, logarithmic image sensors achieve wide dynamic range easily at video rates, but, unlike the human eye, they suffer from low peak signal-to-noise-and-distortion ratios (PSNDRs. To improve the PSNDR, we propose integrating a delta-sigma analog-to-digital converter (ADC in each pixel. An image sensor employing this architecture is designed, built and tested in 0.18 micron complementary metal-oxide-semiconductor (CMOS technology. It achieves a PSNDR better than state-of-the-art logarithmic sensors and comparable to the human eye. As the approach concerns an array of many ADCs, we use a small-area low-power delta-sigma design. For scalability, each pixel has its own decimator. The prototype is compared to a variety of other image sensors, linear and nonlinear, from industry and academia.

  1. Digital pixel sensor array with logarithmic delta-sigma architecture.

    Science.gov (United States)

    Mahmoodi, Alireza; Li, Jing; Joseph, Dileepan

    2013-08-16

    Like the human eye, logarithmic image sensors achieve wide dynamic range easily at video rates, but, unlike the human eye, they suffer from low peak signal-to-noise-and-distortion ratios (PSNDRs). To improve the PSNDR, we propose integrating a delta-sigma analog-to-digital converter (ADC) in each pixel. An image sensor employing this architecture is designed, built and tested in 0.18 micron complementary metal-oxide-semiconductor (CMOS) technology. It achieves a PSNDR better than state-of-the-art logarithmic sensors and comparable to the human eye. As the approach concerns an array of many ADCs, we use a small-area low-power delta-sigma design. For scalability, each pixel has its own decimator. The prototype is compared to a variety of other image sensors, linear and nonlinear, from industry and academia.

  2. Sigma-model soliton intersections from exceptional calibrations

    CERN Document Server

    Portugues, R

    2002-01-01

    A first-order `BPS' equation is obtained for 1/8 supersymmetric intersections of soliton-membranes (lumps) of supersymmetric (4+1)-dimensional massless sigma models, and a special non-singular solution is found that preserves 1/4 supersymmetry. For 4-dimensional hyper-K\\"ahler target spaces ($HK_4$) the BPS equation is shown to be the low-energy limit of the equation for a Cayley-calibrated 4-surface in $\\bE^4\\times HK_4$. Similar first-order equations are found for stationary intersections of Q-lump-membranes of the massive sigma model, but now generic solutions preserve either 1/8 supersymmetry or no supersymmetry, depending on the time orientation.

  3. D-brane Solitons in Supersymmetric Sigma-Models

    CERN Document Server

    Gauntlett, J P; Tong, D; Townsend, P K; Gauntlett, Jerome P.; Portugues, Rubén; Tong, David; Townsend, Paul K.

    2001-01-01

    Massive D=4 N=2 supersymmetric sigma models typically admit domain wall (Q-kink) solutions and string (Q-lump) solutions, both preserving 1/2 supersymmetry. We exhibit a new static 1/4 supersymmetric `kink-lump' solution in which a string ends on a wall, and show that it has an effective realization as a BIon of the D=4 super DBI-action. It is also shown to have a time-dependent Q-kink-lump generalization which reduces to the Q-lump in a limit corresponding to infinite BI magnetic field. All these 1/4 supersymmetric sigma-model solitons are shown to be realized in M-theory as calibrated, or `Q-calibrated', M5-branes in an M-monopole background.

  4. Is health care ready for Six Sigma quality?

    Science.gov (United States)

    Chassin, M R

    1998-01-01

    Serious, widespread problems exist in the quality of U.S. health care: too many patients are exposed to the risks of unnecessary services; opportunities to use effective care are missed; and preventable errors lead to injuries. Advanced practitioners of industrial quality management, like Motorola and General Electric, have committed themselves to reducing the frequency of defects in their business processes to fewer than 3.4 per million, a strategy known as Six Sigma Quality. In health care, quality problems frequently occur at rates of 20 to 50 percent, or 200,000 to 500,000 per million. In order to approach Six Sigma levels of quality, the health care sector must address the underlying causes of error and make important changes: adopting new educational models; devising strategies to increase consumer awareness; and encouraging public and private investment in quality improvement.

  5. The coupling of Poisson sigma models to topological backgrounds

    Science.gov (United States)

    Rosa, Dario

    2016-12-01

    We extend the coupling to the topological backgrounds, recently worked out for the 2-dimensional BF-model, to the most general Poisson sigma models. The coupling involves the choice of a Casimir function on the target manifold and modifies the BRST transformations. This in turn induces a change in the BRST cohomology of the resulting theory. The observables of the coupled theory are analyzed and their geometrical interpretation is given. We finally couple the theory to 2-dimensional topological gravity: this is the first step to study a topological string theory in propagation on a Poisson manifold. As an application, we show that the gauge-fixed vectorial supersymmetry of the Poisson sigma models has a natural explanation in terms of the theory coupled to topological gravity.

  6. Comparative proteome analysis reveals conserved and specific adaptation patterns of Staphylococcus aureus after internalization by different types of human non-professional phagocytic host cells.

    Science.gov (United States)

    Surmann, Kristin; Michalik, Stephan; Hildebrandt, Petra; Gierok, Philipp; Depke, Maren; Brinkmann, Lars; Bernhardt, Jörg; Salazar, Manuela G; Sun, Zhi; Shteynberg, David; Kusebauch, Ulrike; Moritz, Robert L; Wollscheid, Bernd; Lalk, Michael; Völker, Uwe; Schmidt, Frank

    2014-01-01

    Staphylococcus aureus is a human pathogen that can cause a wide range of diseases. Although formerly regarded as extracellular pathogen, it has been shown that S. aureus can also be internalized by host cells and persist within these cells. In the present study, we comparatively analyzed survival and physiological adaptation of S. aureus HG001 after internalization by two human lung epithelial cell lines (S9 and A549), and human embryonic kidney cells (HEK 293). Combining enrichment of bacteria from host-pathogen assays by cell sorting and quantitation of the pathogen's proteome by mass spectrometry we characterized S. aureus adaptation during the initial phase between 2.5 h and 6.5 h post-infection. Starting with about 2 × 10(6) bacteria, roughly 1450 S. aureus proteins, including virulence factors and metabolic enzymes were identified by spectral comparison and classical database searches. Most of the bacterial adaptation reactions, such as decreased levels of ribosomal proteins and metabolic enzymes or increased amounts of proteins involved in arginine and lysine biosynthesis, enzymes coding for terminal oxidases and stress responsive proteins or activation of the sigma factor SigB were observed after internalization into any of the three cell lines studied. However, differences were noted in central carbon metabolism including regulation of fermentation and threonine degradation. Since these differences coincided with different intracellular growth behavior, complementary profiling of the metabolome of the different non-infected host cell types was performed. This revealed similar levels of intracellular glucose but host cell specific differences in the amounts of amino acids such as glycine, threonine or glutamate. With this comparative study we provide an impression of the common and specific features of the adaptation of S. aureus HG001 to specific host cell environments as a starting point for follow-up studies with different strain isolates and regulatory

  7. Comparative proteome analysis reveals conserved and specific adaptation patterns of Staphylococcus aureus after internalization by different types of human non-professional phagocytic host cells

    Directory of Open Access Journals (Sweden)

    Kristin eSurmann

    2014-08-01

    Full Text Available Staphylococcus aureus is a human pathogen that can cause a wide range of diseases. Although formerly regarded as extracellular pathogen, it has been shown that S. aureus can also be internalized by host cells and persist within these cells. In the present study, we comparatively analyzed survival and physiological adaptation of S. aureus HG001 after internalization by two human lung epithelial cell lines (S9 and A549, and human embryonic kidney cells (HEK 293. Combining enrichment of bacteria from host-pathogen assays by cell sorting and quantitation of the pathogen´s proteome by mass spectrometry we characterized S. aureus adaptation during the initial phase between 2.5 h and 6.5 h post-infection. Starting with about 2x106 bacteria, roughly 1,450 S. aureus proteins, including virulence factors and metabolic enzymes were identified by spectral comparison and classical database searches. Most of the bacterial adaptation reactions, such as decreases in levels of ribosomal proteins and metabolic enzymes or increases in amounts of proteins involved in arginine and lysine biosynthesis, coding for terminal oxidases and stress responsive genes or activation of the sigma factor SigB were observed after internalization into any of the three cell lines studied. However, differences were noted in central carbon metabolism including regulation of fermentation and threonine degradation. Since these differences coincided with different intracellular growth behavior, complementary profiling of the metabolome of the different non-infected host cell types was performed. This revealed similar levels of intracellular glucose but host cell specific differences in the amounts of amino acids such as glycine, threonine or glutamate. With this comparative study we provide an impression of the common and specific features of the adaptation of S. aureus HG001 to specific host cell environments as a starting point for follow-up studies with different strain isolates and

  8. Comparative proteome analysis reveals conserved and specific adaptation patterns of Staphylococcus aureus after internalization by different types of human non-professional phagocytic host cells

    Science.gov (United States)

    Surmann, Kristin; Michalik, Stephan; Hildebrandt, Petra; Gierok, Philipp; Depke, Maren; Brinkmann, Lars; Bernhardt, Jörg; Salazar, Manuela G.; Sun, Zhi; Shteynberg, David; Kusebauch, Ulrike; Moritz, Robert L.; Wollscheid, Bernd; Lalk, Michael; Völker, Uwe; Schmidt, Frank

    2014-01-01

    Staphylococcus aureus is a human pathogen that can cause a wide range of diseases. Although formerly regarded as extracellular pathogen, it has been shown that S. aureus can also be internalized by host cells and persist within these cells. In the present study, we comparatively analyzed survival and physiological adaptation of S. aureus HG001 after internalization by two human lung epithelial cell lines (S9 and A549), and human embryonic kidney cells (HEK 293). Combining enrichment of bacteria from host-pathogen assays by cell sorting and quantitation of the pathogen's proteome by mass spectrometry we characterized S. aureus adaptation during the initial phase between 2.5 h and 6.5 h post-infection. Starting with about 2 × 106 bacteria, roughly 1450 S. aureus proteins, including virulence factors and metabolic enzymes were identified by spectral comparison and classical database searches. Most of the bacterial adaptation reactions, such as decreased levels of ribosomal proteins and metabolic enzymes or increased amounts of proteins involved in arginine and lysine biosynthesis, enzymes coding for terminal oxidases and stress responsive proteins or activation of the sigma factor SigB were observed after internalization into any of the three cell lines studied. However, differences were noted in central carbon metabolism including regulation of fermentation and threonine degradation. Since these differences coincided with different intracellular growth behavior, complementary profiling of the metabolome of the different non-infected host cell types was performed. This revealed similar levels of intracellular glucose but host cell specific differences in the amounts of amino acids such as glycine, threonine or glutamate. With this comparative study we provide an impression of the common and specific features of the adaptation of S. aureus HG001 to specific host cell environments as a starting point for follow-up studies with different strain isolates and regulatory

  9. A Lean Six Sigma Analysis of Student In-Processing

    Science.gov (United States)

    2012-12-01

    IV and V of this thesis. D. THEORY OF CONSTRAINTS Popularized in the book “The Goal” by Eli Goldratt , the Theory of Constraints (ToC) applies...effectively to Lean Six Sigma efforts. Goldratt analyzed systems in an effort to identify constraints, or bottlenecks. Once the constraint is...service. New York: McGraw- Hill. Goldratt , E. M., & Cox, J. The Goal: A process of ongoing improvement. 3rd rev. ed., 25th anniversary ed. Great

  10. Conformal Sigma Models with Anomalous Dimensions and Ricci Solitons

    CERN Document Server

    Nitta, M

    2004-01-01

    We present new non-Ricci-flat Kahler metrics with U(N) and O(N) isometries as target manifolds of conformally invariant sigma models with an anomalous dimension. They are so-called Ricci solitons, special solutions to a Ricci-flow equation. These metrics explicitly contain the anomalous dimension and reduce to Ricci-flat Kahler metrics on the canonical line bundles over certain coset spaces in the limit of vanishing anomalous dimension.

  11. Comparing Poisson Sigma Model with A-model

    Science.gov (United States)

    Bonechi, F.; Cattaneo, A. S.; Iraso, R.

    2016-10-01

    We discuss the A-model as a gauge fixing of the Poisson Sigma Model with target a symplectic structure. We complete the discussion in [4], where a gauge fixing defined by a compatible complex structure was introduced, by showing how to recover the A-model hierarchy of observables in terms of the AKSZ observables. Moreover, we discuss the off-shell supersymmetry of the A-model as a residual BV symmetry of the gauge fixed PSM action.

  12. Does the {sigma}(1580)((3)/(2)){sup -} resonance exist?

    Energy Technology Data Exchange (ETDEWEB)

    Olmsted, J.; Prakhov, S.; Manley, D.M.; Allgower, C.E.; Bekrenev, V.S.; Briscoe, W.J.; Clajus, M.; Comfort, J.R.; Craig, K.; Grosnick, D.; Isenhower, D.; Knecht, N.; Koetke, D.D.; Kozlenko, N.G.; Kruglov, S.; Kulbardis, A.A.; Lolos, G.; Lopatin, I.V.; Manweiler, R.; Marusic, A.; McDonald, S.; Nefkens, B.M.K.; Papandreou, Z.; Peaslee, D.C.; Phaisangittisakul, N.; Price, J.W.; Ramirez, A.F.; Sadler, M.; Shafi, A.; Spinka, H.; Stanislaus, T.D.S.; Starostin, A.; Staudenmaier, H.M.; Strakovsky, I.I.; Supek, I.; Tippens, W.B

    2004-05-20

    Precise new data for the reaction K{sup -}p{yields}{pi}{sup 0}{lambda} are presented in the c.m. energy range 1565 to 1600 MeV. Our analysis of these data sheds new light on claims for the {sigma}(1580)((3)/(2)){sup -} resonance, which (if it exists with the specified quantum numbers) must be an exotic baryon because of its very low mass. Our results show no evidence for this state.

  13. Does the Sigma(1580)3/2- resonance exist?

    CERN Document Server

    Olmsted, J A; Manley, D M; Allgower, C E; Bekrenev, V S; Briscoe, W J; Clajus, M; Comfort, J R; Craig, K; Grosnick, D P; Isenhower, D; Knecht, N; Koetke, D D; Kozlenko, N G; Kruglov, S; Kulbardis, A A; Lolos, G J; Lopatin, I V; Manweiler, R; Marusic, A; McDonald, S; Nefkens, B M K; Papandreou, Z; Peaslee, D C; Phaisangittisakul, N; Price, J W; Ramírez, A F; Sadler, M E; Shafi, A; Spinka, H M; Stanislaus, T D S; Starostin, A S; Staudenmaier, H M; Strakovsky, I I; Supek, I; Tippens, W B; Tippens, and W.B.

    2003-01-01

    Precise new data for the reaction $K^- p \\to \\pi^0 \\Lambda$ are presented in the c.m. energy range 1565 to 1600 MeV. Our analysis of these data sheds new light on claims for the $\\Sigma(1580){3/2}^-$ resonance, which (if it exists with the specified quantum numbers) must be an exotic baryon because of its very low mass. Our results are decisive and show no evidence for this state.

  14. Evidence for the rare decay $\\Sigma^+ \\to p \\mu^+ \\mu^-$

    CERN Document Server

    The LHCb Collaboration

    2016-01-01

    A search for the rare decay $\\Sigma^+ \\to p \\mu^+ \\mu^-$ is performed using $pp$ collision data recorded by the LHCb experiment at centre-of-mass energies $\\sqrt{s} = 7$ and $8 TeV$, corresponding to an integrated luminosity of $3 ~ \\text {fb}^{-1}$. An excess of events is observed with respect to the background expectations with a signal significance of 4.0 standard deviations. No significant structure is observed in the dimuon invariant mass distribution.

  15. Color screening, absorption and $\\sigma_{tot}^{pp}$ at LHC

    CERN Document Server

    Fiore, R; Zoller, V R

    2014-01-01

    We show that a growth of the proton-proton total cross section with energy can be entirely attributed to the purely perturbative mechanism. The infrared regularization at rather short distances, $R_c\\simeq 0.3$ fm, allows to extend the BFKL technique from deep inelastic to hadron-hadron scattering. With the account of the absorption corrections our results are in agreement with the LHC data on $\\sigma_{tot}^{pp}$.

  16. Continuous-Time Delta-Sigma Modulators for Wireless Communication

    OpenAIRE

    Andersson, Mattias

    2014-01-01

    The ever increasing data rates in wireless communication require analog to digital converters (ADCs) with greater requirements on speed and accuracy, while being power efficient to prolong battery life. This dissertation contains an introduction to the field and five papers that focus on the continuous-time (CT) Delta-Sigma modulator (DSM) as ADC. Paper I analyses the performance degradation of dynamic nonlinearity in the feedback DAC of the DSM, caused by Vth mismatch in the current-s...

  17. Topological Twisted Sigma Model with H-flux Revisited

    Energy Technology Data Exchange (ETDEWEB)

    Chuang, Wu-yen

    2006-08-18

    In this paper we revisit the topological twisted sigma model with H-flux. We explicitly expand and then twist the worldsheet Lagrangian for bi-Hermitian geometry. we show that the resulting action consists of a BRST exact term and pullback terms, which only depend on one of the two generalized complex structures and the B-field. We then discuss the topological feature of the model.

  18. 2D Poisson sigma models with gauged vectorial supersymmetry

    OpenAIRE

    2015-01-01

    In this note, we gauge the rigid vectorial supersymmetry of the two-dimensional Poisson sigma model presented in arXiv:1503.05625. We show that the consistency of the construction does not impose any further constraints on the differential Poisson algebra geometry than those required for the ungauged model. We conclude by proposing that the gauged model provides a first-quantized framework for higher spin gravity.

  19. 2D Poisson Sigma Models with Gauged Vectorial Supersymmetry

    CERN Document Server

    Bonezzi, Roberto; Torres-Gomez, Alexander

    2015-01-01

    In this note, we gauge the rigid vectorial supersymmetry of the two-dimensional Poisson sigma model presented in arXiv:1503.05625. We show that the consistency of the construction does not impose any further constraints on the differential Poisson algebra geometry than those required for the ungauged model. We conclude by proposing that the gauged model provides a first-quantized framework for higher spin gravity.

  20. 2D Poisson sigma models with gauged vectorial supersymmetry

    Science.gov (United States)

    Bonezzi, Roberto; Sundell, Per; Torres-Gomez, Alexander

    2015-08-01

    In this note, we gauge the rigid vectorial supersymmetry of the two-dimensional Poisson sigma model presented in arXiv:1503.05625. We show that the consistency of the construction does not impose any further constraints on the differential Poisson algebra geometry than those required for the ungauged model. We conclude by proposing that the gauged model provides a first-quantized framework for higher spin gravity.

  1. The Nonlinear Sigma Model With Distributed Adaptive Mesh Refinement

    CERN Document Server

    Liebling, S L

    2004-01-01

    An adaptive mesh refinement (AMR) scheme is implemented in a distributed environment using Message Passing Interface (MPI) to find solutions to the nonlinear sigma model. Previous work studied behavior similar to black hole critical phenomena at the threshold for singularity formation in this flat space model. This work is a follow-up describing extensions to distribute the grid hierarchy and presenting tests showing the correctness of the model.

  2. The innovative use of Six Sigma in home care.

    Science.gov (United States)

    Elberfeld, Adrienne; Bennis, Sandra; Ritzius, Jeannie; Yhlen, David

    2007-01-01

    The Prospective Payment System had significant impact on home healthcare agencies throughout the nation. Virtua Home Care, located in Southern New Jersey, realized the need for process improvement in order to remain viable. Six Sigma was introduced to the agency and the Define, Measure, Analyze, Improve, and Control processes were initiated to achieve sustainable results, and within 9 months, Virtua Home Care improved regulatory compliance, experienced a deficiency-free survey, and recognized a 1.2 million dollars financial gain.

  3. A community hospital's journey into Lean Six Sigma.

    Science.gov (United States)

    Stuenkel, Kurt; Faulkner, Taunya

    2009-01-01

    The implementation of Lean Six Sigma and 100-day workouts throughout the 304-bed Floyd Medical Center community hospital organization has led to sustainable results and a marked change in culture. The organization-wide learning of such an effort is deep and intehse, and to remain focused and successful it must be a priority of top management. The workout methodology can assist the organization to carry projects to completion and to achieve rapid implementation of desired improvements.

  4. Supersymmetric Q-Lumps in the Grassmannian nonlinear sigma models

    CERN Document Server

    Bak, D; Lee, J; Oh, P; Bak, Dongsu; Hahn, Sang-Ok; Lee, Joohan; Oh, Phillial

    2007-01-01

    We construct the N=2 supersymmetric Grassmannian nonlinear sigma model for the massless case and extend it to massive N=2 model by adding an appropriate superpotential. We then study their BPS equations leading to supersymmetric Q-lumps carrying both topological and Noether charges. These solutions are shown to be always time dependent even sometimes involving multiple frequencies. Thus we illustrate explicitly that the time dependence is consistent with remaining supersymmetries of solitons.

  5. Statistical and Managerial Techniques for Six Sigma Methodology Theory and Application

    CERN Document Server

    Barone, Stefano

    2012-01-01

    Statistical and Managerial Techniques for Six Sigma Methodology examines the methodology through illustrating the most widespread tool and techniques involved in Six Sigma application. Both managerial and statistical aspects of Six Sigma will be analyzed, allowing the reader to apply these tools in the field. This book offers an insight on variation and risk management, and focuses on the structure and organizational aspects of the Six Sigma projects. It covers six sigma methodology, basic managerial techniques, basic statistical techniques, methods for variation and risk management and advanc

  6. SU($4$) Polyakov linear-sigma model at finite temperature and density

    CERN Document Server

    Diab, Abdel Magied; Tawfik, Abdel Nasser; Dahab, Eiman Abou El

    2016-01-01

    In mean-field approximation, the SU($4$) Polyakov linear - sigma model (PLSM) is constructed in order to characterize the quark-hadron phase structure in a wide range of temperatures and densities. The chiral condensates $\\sigma_l$, $\\sigma_s$ and $\\sigma_c$ for light, strange and charm quarks, respectively, and the deconfinement order-parameters $\\phi$ and $\\phi^*$ shall be analyzed at finite temperatures and densities. We conclude that the critical temperatures corresponding to charm condensates are greater than that to strange and light ones, respectively. Thus, the charm condensates are likely not affected by the QCD phase transition. Furthermore, increasing the chemical potentials decreases the corresponding critical temperatures.

  7. Energy Dependence of the Lambda-Sigma0 Production in Proton-Proton Collisions

    CERN Document Server

    Dillig, M

    2006-01-01

    The energy dependence of the reactions pp -> p Lambda K+ and pp -> p Sigma0 K+ and the ratio R(Lambda/Sigma0} is studied in a constituent quark-gluon model, including the excitation of the baryon resonances N*(1650), N*(1710) and N*(1720) near the Lambda/Sigma0 thresholds. Representing the baryons as quark-diquark objects, the energy dependent ratio Lambda/Sigma0, which is qualitatively reproduced up to excess energies of 60 MeV above threshold, provides detailed information on the momentum spectrum of axial diquarks in the proton and the Sigma0.

  8. The L-sigma Relation of Local HII Galaxies

    CERN Document Server

    Bordalo, Vinicius

    2011-01-01

    We present for the first time a new data set of emission line widths for 118 star-forming regions in HII galaxies (HIIGs). This homogeneous set is used to investigate the L-sigma relation in conjunction with optical spectrophotometric observations. Peculiarities in the line profiles such as sharp lines, wings, asymmetries, and in some cases more than one component in emission were verified. From a new independent homogeneous set of spectrophotometric data we derived physical condition parameters and performed the statistical principal component analysis. We have investigated the potential role of metallicity (O/H), Hbeta equivalent width (WHbeta) and ionization ratio [OIII]/[OII] to account for the observational scatter of L-sigma relation. Our results indicate that the L-sigma relation for HIIGs is more sensitive to the evolution of the current starburst event (short-term evolution) and dated by WHbeta or even the [OIII]/[OII] ratio. The long-term evolution measured by O/H also plays a potential role in dete...

  9. Multiple-Description Coding by Dithered Delta-Sigma Quantization

    CERN Document Server

    Ostergaard, Jan

    2007-01-01

    We address the connection between the multiple-description (MD) problem and Delta-Sigma quantization. The inherent redundancy due to oversampling in Delta-Sigma quantization, and the simple linear-additive noise model resulting from dithered lattice quantization, allow us to construct a symmetric MD coding scheme. We show that the use of a noise shaping filter makes it possible to trade off central distortion for side distortion. Asymptotically as the dimension of the lattice vector quantizer and order of the noise shaping filter approach infinity, the entropy rate of the dithered Delta-Sigma quantization scheme approaches the symmetric two-channel MD rate-distortion function for a memoryless Gaussian source and MSE fidelity criterion, at any side-to-central distortion ratio and any resolution. In the optimal scheme, the infinite-order noise shaping filter must be minimum phase and have a piece-wise flat power spectrum with a single jump discontinuity. We further show that the optimal noise-shaping filter of ...

  10. Precision measurement of the {Sigma}{sup 0} hyperon mass

    Energy Technology Data Exchange (ETDEWEB)

    Wang, M.H.L.S.; Hartouni, E.P.; Kreisler, M.N. [and others

    1998-02-17

    The research that is described in this paper is part of a program to study strong interaction mechanisms in proton proton collisions. The program consists of two experiments: Brookhaven E766 in which we studied the reactions pp {yields} p+ all charged particles with 27.5 GeV/c incident protons and Fermilab E690 in which we studied the reactions pp {yields} p+ all charged particles with 800 GeV/c incident protons. In these experiments, we employed state-of-the-art data acquisition sys- tems and acquired large samples of data: at Brookhaven we amassed 300 million high multiplicity events and at Fermilab, 5.5 billion events. Our uncertainty in the {Sigma}{sup 0} mass is more than 7 times smaller than the best previous result and was based on 16 times the statistics. Likewise, the {Sigma}{sup 0} - {Lambda}{sup 0} mass difference is more than 14 times more accurate than the previous best result. Finally, we note that this measurement is the first direct measurement of the {Sigma}{sup 0} mass.

  11. Sigma models for genuinely non-geometric backgrounds

    CERN Document Server

    Chatzistavrakidis, Athanasios; Lechtenfeld, Olaf

    2015-01-01

    The existence of genuinely non-geometric backgrounds, i.e. ones without geometric dual, is an important question in string theory. In this paper we examine this question from a sigma model perspective. First we construct a particular class of Courant algebroids as protobialgebroids with all types of geometric and non-geometric fluxes. For such structures we apply the mathematical result that any Courant algebroid gives rise to a 3D topological sigma model of the AKSZ type and we discuss the corresponding 2D field theories. It is found that these models are always geometric, even when both 2-form and 2-vector fields are neither vanishing nor inverse of one another. Taking a further step, we suggest an extended class of 3D sigma models, whose world volume is embedded in phase space, which allow for genuinely non-geometric backgrounds. Adopting the doubled formalism such models can be related to double field theory, albeit from a world sheet perspective.

  12. Sigma factors in a thousand E. coli genomes

    DEFF Research Database (Denmark)

    Cook, Helen Victoria; Ussery, David

    2013-01-01

    , we describe a method to quickly sort through genomes for a particular set of protein families. We apply these two methods to all of the current Escherichia coli genomes available in the The National Center for Biotechnology Information database. Out of the 2074 E. coli/Shigella genomes listed (June......, 2013), only less than half (983) are of sufficient quality to use in comparative genomic work. Unfortunately, even some of the ‘complete’ E. coli genomes are in pieces, and a few ‘draft’ genomes are good quality. Six of the seven known sigma factors in E. coli strain K‐12 are extremely well conserved......; the iron‐regulating sigma factor FecI (σ19) is missing in most genomes. Surprisingly, the E. coli strain CFT073 genome does not encode a functional RpoD (σ70), which is obviously essential, and this is likely due to poor genome assembly/annotation. We find a possible novel sigma factor present in more than...

  13. The Bacillus subtilis flagellar regulatory protein sigma D: overproduction, domain analysis and DNA-binding properties.

    Science.gov (United States)

    Chen, Y F; Helmann, J D

    1995-06-16

    Flagellar biosynthesis requires an alternative sigma (sigma) subunit of RNA polymerase to allow recognition of the promoters for flagellin and other late genes of the flagellar regulon. We have now overproduced and characterized Bacillus subtilis sigma D: the prototype of the sigma 28 family of flagellar sigma factors. Limited protease digestion studies indicate that sigma D contains an amino-terminal domain, comprising conserved regions 1.2 and 2, and a carboxyl-terminal domain containing conserved regions 3.2 and 4. The protease-sensitive region between these two domains correlates with a region of very low sequence conservation among bacterial sigma factors. Unlike the primary sigma factor, sigma D binds to DNA. In non-denaturing polyacrylamide gel electrophoresis the sigma D-DNA complex has an apparent equilibrium dissociation constant of 1 microM. Binding of sigma D to the promoter for flagellin, PD-6, appears to lead to an altered DNA structure near the -35 and -10 recognition elements as detected by DNase I footprinting and by the enhanced reactivity of several bases to dimethylsulfate.

  14. Genome-scale reconstruction of the sigma factor network in Escherichia coli: topology and functional states

    DEFF Research Database (Denmark)

    Cho, Byung-Kwan; Kim, Donghyuk; Knight, Eric M.

    2014-01-01

    to transcription units (TUs), representing an increase of more than 300% over what has been previously reported. The reconstructed network was used to investigate competition between alternative sigma-factors (the sigma(70) and sigma(38) regulons), confirming the competition model of sigma substitution......Background: At the beginning of the transcription process, the RNA polymerase (RNAP) core enzyme requires a sigma-factor to recognize the genomic location at which the process initiates. Although the crucial role of sigma-factors has long been appreciated and characterized for many individual...... promoters, we do not yet have a genome-scale assessment of their function. Results: Using multiple genome-scale measurements, we elucidated the network of s-factor and promoter interactions in Escherichia coli. The reconstructed network includes 4,724 sigma-factor-specific promoters corresponding...

  15. The hallucinogen N,N-dimethyltryptamine (DMT) is an endogenous sigma-1 receptor regulator.

    Science.gov (United States)

    Fontanilla, Dominique; Johannessen, Molly; Hajipour, Abdol R; Cozzi, Nicholas V; Jackson, Meyer B; Ruoho, Arnold E

    2009-02-13

    The sigma-1 receptor is widely distributed in the central nervous system and periphery. Originally mischaracterized as an opioid receptor, the sigma-1 receptor binds a vast number of synthetic compounds but does not bind opioid peptides; it is currently considered an orphan receptor. The sigma-1 receptor pharmacophore includes an alkylamine core, also found in the endogenous compound N,N-dimethyltryptamine (DMT). DMT acts as a hallucinogen, but its receptor target has been unclear. DMT bound to sigma-1 receptors and inhibited voltage-gated sodium ion (Na+) channels in both native cardiac myocytes and heterologous cells that express sigma-1 receptors. DMT induced hypermobility in wild-type mice but not in sigma-1 receptor knockout mice. These biochemical, physiological, and behavioral experiments indicate that DMT is an endogenous agonist for the sigma-1 receptor.

  16. Characterizing the interplay between multiple levels of organization within bacterial sigma factor regulatory networks.

    Science.gov (United States)

    Qiu, Yu; Nagarajan, Harish; Embree, Mallory; Shieu, Wendy; Abate, Elisa; Juárez, Katy; Cho, Byung-Kwan; Elkins, James G; Nevin, Kelly P; Barrett, Christian L; Lovley, Derek R; Palsson, Bernhard O; Zengler, Karsten

    2013-01-01

    Bacteria contain multiple sigma factors, each targeting diverse, but often overlapping sets of promoters, thereby forming a complex network. The layout and deployment of such a sigma factor network directly impacts global transcriptional regulation and ultimately dictates the phenotype. Here we integrate multi-omic data sets to determine the topology, the operational, and functional states of the sigma factor network in Geobacter sulfurreducens, revealing a unique network topology of interacting sigma factors. Analysis of the operational state of the sigma factor network shows a highly modular structure with σ(N) being the major regulator of energy metabolism. Surprisingly, the functional state of the network during the two most divergent growth conditions is nearly static, with sigma factor binding profiles almost invariant to environmental stimuli. This first comprehensive elucidation of the interplay between different levels of the sigma factor network organization is fundamental to characterize transcriptional regulatory mechanisms in bacteria.

  17. Characterizing the interplay betwen mulitple levels of organization within bacterial sigma factor regulatory networks

    Energy Technology Data Exchange (ETDEWEB)

    Yu, Qiu [University of California, San Diego; Nagarajan, Harish [University of California, San Diego; Embree, Mallory [University of California, San Diego; Shieu, Wendy [University of California, San Diego; Abate, Elisa [University of California, San Diego; Juarez, Katy [Universidad Nacional Autonoma de Mexico (UNAM); Cho, Byung-Kwan [University of California, San Diego; Elkins, James G [ORNL; Nevin, Kelly P. [University of Massachusetts, Amherst; Barrett, Christian [University of California, San Diego; Lovley, Derek [University of Massachusetts, Amherst; Palsson, Bernhard O. [University of California, San Diego; Zengler, Karsten [University of California, San Diego

    2013-01-01

    Bacteria contain multiple sigma factors, each targeting diverse, but often overlapping sets of promoters, thereby forming a complex network. The layout and deployment of such a sigma factor network directly impacts global transcriptional regulation and ultimately dictates the phenotype. Here we integrate multi-omic data sets to determine the topology, the operational, and functional states of the sigma factor network in Geobacter sulfurreducens, revealing a unique network topology of interacting sigma factors. Analysis of the operational state of the sigma factor network shows a highly modular structure with sN being the major regulator of energy metabolism. Surprisingly, the functional state of the network during the two most divergent growth conditions is nearly static, with sigma factor binding profiles almost invariant to environmental stimuli. This first comprehensive elucidation of the interplay between different levels of the sigma factor network organization is fundamental to characterize transcriptional regulatory mechanisms in bacteria.

  18. A shock-tube measurement of the SiO/E 1 Sigma + - X 1 Sigma +/ transition moment

    Science.gov (United States)

    Park, C.

    1978-01-01

    The sum of the squares of the electronic transition moments for the (E 1 Sigma +) - (X 1 Sigma +) band system of SiO has been determined from absorption measurements conducted in the reflected-shock region of a shock tube. The test gas produced by shock-heating a mixture of SiCl4, N2O, and Ar, and the spectra were recorded photographically in the 150-230-nm wavelength range. The values of the sum of the squares were determined by comparing the measured absorption spectra with those produced by a line-by-line synthetic spectrum calculation. The value so deduced at an r-centroid value of 3.0 bohr was 0.86 + or - 0.10 atomic unit.

  19. Comparison of binding parameters of sigma 1 and sigma 2 binding sites in rat and guinea pig brain membranes: novel subtype-selective trishomocubanes.

    Science.gov (United States)

    Nguyen, V H; Kassiou, M; Johnston, G A; Christie, M J

    1996-09-12

    Comparisons of binding parameters of [3H](+)-pentazocine and [3H]1,3-di-o-tolylguanidine (DTG) at sigma binding sites in guinea pig and rat brain membranes demonstrated that [3H](+)-pentazocine binds to a single high-affinity site, whereas [3H]DTG binds to two high-affinity sites in both species. The Kd values of the radioligands were similar in both types of membranes. However, the density of sigma 1 sites in guinea pig was significantly higher than that of rat. Novel trishomocubanes were tested for their affinities at sigma 1 and sigma 2 binding sites in guinea pig brain membranes using [3H](+)-pentazocine and [3H]DTG as the radioligands. N-(4-Phenylbutyl)-3-hydroxy-4- azahexacyclo[5.4.1.0(2,6).0(3,10).0(5,9).0(8,11)]dodecane (ANSTO-14) showed the highest affinity for the sigma 1 site (Ki = 9.4 nM) and 19-fold sigma 1/sigma 2 selectivity, as a result of increasing the alkyl chain between the cubane moiety and the aromatic ring. N-(3'-Fluorophenyl)methyl- 3-hydroxy-4-azahexacyclo[5.4.1.0(2,6).0(3,10).0(5,9).0(8,11]dodeca ne (ANSTO-19), displayed the highest affinity for sigma 2 sites (Ki = 19.6 nM) and 8-fold sigma 2/sigma 1 selectivity due to a fluoro substitution in the meta position of the aromatic ring. These represent structurally novel lead compounds, especially for the development of selective sigma 2 receptor ligands.

  20. Staphylococcus aureus Shifts toward Commensalism in Response to Corynebacterium Species.

    Science.gov (United States)

    Ramsey, Matthew M; Freire, Marcelo O; Gabrilska, Rebecca A; Rumbaugh, Kendra P; Lemon, Katherine P

    2016-01-01

    Staphylococcus aureus-human interactions result in a continuum of outcomes from commensalism to pathogenesis. S. aureus is a clinically important pathogen that asymptomatically colonizes ~25% of humans as a member of the nostril and skin microbiota, where it resides with other bacteria including commensal Corynebacterium species. Commensal Corynebacterium spp. are also positively correlated with S. aureus in chronic polymicrobial diabetic foot infections, distinct from acute monomicrobial S. aureus infections. Recent work by our lab and others indicates that microbe-microbe interactions between S. aureus and human skin/nasal commensals, including Corynebacterium species, affect S. aureus behavior and fitness. Thus, we hypothesized that S. aureus interactions with Corynebacterium spp. diminish S. aureus virulence. We tested this by assaying for changes in S. aureus gene expression during in vitro mono- versus coculture with Corynebacterium striatum, a common skin and nasal commensal. We observed a broad shift in S. aureus gene transcription during in vitro growth with C. striatum, including increased transcription of genes known to exhibit increased expression during human nasal colonization and decreased transcription of virulence genes. S. aureus uses several regulatory pathways to transition between commensal and pathogenic states. One of these, the quorum signal accessory gene regulator (agr) system, was strongly inhibited in response to Corynebacterium spp. Phenotypically, S. aureus exposed to C. striatum exhibited increased adhesion to epithelial cells, reflecting a commensal state, and decreased hemolysin activity, reflecting an attenuation of virulence. Consistent with this, S. aureus displayed diminished fitness in experimental in vivo coinfection with C. striatum when compared to monoinfection. These data support a model in which S. aureus shifts from virulence toward a commensal state when exposed to commensal Corynebacterium species.

  1. Exploring the role of sigma factor gene expression on production by Corynebacterium glutamicum: sigma factor H and FMN as example.

    Science.gov (United States)

    Taniguchi, Hironori; Wendisch, Volker F

    2015-01-01

    Bacteria are known to cope with environmental changes by using alternative sigma factors binding to RNA polymerase core enzyme. Sigma factor is one of the targets to modify transcription regulation in bacteria and to influence production capacities. In this study, the effect of overexpressing each annotated sigma factor gene in Corynebacterium glutamicum WT was assayed using an IPTG inducible plasmid system and different IPTG concentrations. It was revealed that growth was severely decreased when sigD or sigH were overexpressed with IPTG concentrations higher than 50 μM. Overexpression of sigH led to an obvious phenotypic change, a yellow-colored supernatant. High performance liquid chromatography analysis revealed that riboflavin was excreted to the medium when sigH was overexpressed and DNA microarray analysis confirmed increased expression of riboflavin biosynthesis genes. In addition, genes for enzymes related to the pentose phosphate pathway and for enzymes dependent on flavin mononucleotide (FMN), flavin adenine dinucleotide (FAD), or NADPH as cofactor were upregulated when sigH was overexpressed. To test if sigH overexpression can be exploited for production of riboflavin-derived FMN or FAD, the endogenous gene for bifunctional riboflavin kinase/FMN adenyltransferase was co-expressed with sigH from a plasmid. Balanced expression of sigH and ribF improved accumulation of riboflavin (19.8 ± 0.3 μM) and allowed for its conversion to FMN (33.1 ± 1.8 μM) in the supernatant. While a proof-of-concept was reached, conversion was not complete and titers were not high. This study revealed that inducible and gradable overexpression of sigma factor genes is an interesting approach to switch gene expression profiles and to discover untapped potential of bacteria for chemical production.

  2. Exploring the role of sigma factor gene expression on production by Corynebacterium glutamicum: sigma factor H and FMN as example

    Directory of Open Access Journals (Sweden)

    Hironori eTaniguchi

    2015-07-01

    Full Text Available Bacteria are known to cope with environmental changes by using alternative sigma factors binding to RNA polymerase core enzyme. Sigma factor is one of the targets to modify transcription regulation in bacteria and to influence production capacities. In this study, the effect of overexpressing each annotated sigma factor gene in C. glutamicum WT was assayed using an IPTG inducible plasmid system and different IPTG concentrations. It was revealed that growth was severely decreased when sigD or sigH were overexpressed with IPTG concentrations higher than 50 μM. Overexpression of sigH led to an obvious phenotypic change, a yellow-colored supernatant. HPLC analysis revealed that riboflavin was excreted to the medium when sigH was overexpressed and DNA microarray analysis confirmed increased expression of riboflavin biosynthesis genes. In addition, genes for enzymes related to the pentose phosphate pathway and for enzymes dependent on FMN, FAD or NADPH as cofactor were upregulated when sigH was overexpressed. To test if sigH overexpression can be exploited for production of riboflavin-derived FMN or FAD, the endogenous gene for bifunctional riboflavin kinase/FMN adenyltransferase was co-expressed with sigH from a plasmid. Balanced expression of sigH and ribF improved accumulation of riboflavin (19.8 ± 0.3 μM and allowed for its conversion to FMN (33.1 ± 1.8 μM in the supernatant. While a proof-of-concept was reached, conversion was not complete and titers were not high. This study revealed that inducible and gradable overexpression of sigma factor genes is an interesting approach to switch gene expression profiles and to discover untapped potential of bacteria for chemical production.

  3. Quasifree Lambda, Sigma^0, and Sigma^- electroproduction from 1,2H, 3,4He, and Carbon

    Energy Technology Data Exchange (ETDEWEB)

    F. Dohrmann; A. Ahmidouch; C.S. Armstrong; J. Arrington; R. Asaturyan; S. Avery; K. Bailey; H. Bitao; H. Breuer; D.S. Brown; R. Carlini; J. Cha; N. Chant; E. Christy; A. Cochran; L. Cole; J. Crowder; S. Danagoulian; M. Elaasar; R. Ent; H. Fenker; Y. Fujii; L. Gan; K. Garrow; D.F. Geesaman; P. Gueye; K. Hafidi; W. Hinton; H. Juengst; C. Keppel; Y. Liang; J.H. Liu; A. Lung; D. Mack; P. Markowitz; J. Mitchell; T. Miyoshi; H. Mkrtchyan; S.K. Mtingwa; B. Mueller; G. Niculescu; I. Niculescu; D. Potterveld; B.A. Raue; P.E. Reimer; J. Reinhold; J. Roche; M. Sarsour; Y. Sato; R.E. Segel; A. Semenov; S. Stepanyan; V. Tadevosyan; S. Tajima; L. Tang; A. Uzzle; S. Wood; H. Yamaguchi; C. Yan; L. Yuan; B. Zeidman; M. Zeier; B. Zihlmann

    2007-07-30

    Kaon electroproduction from light nuclei and hydrogen, using 1H, 2H, 3He, 4He, and Carbon targets has been measured at Jefferson Laboratory. The quasifree angular distributions of Lambda and Sigma hyperons were determined at Q^2= 0.35(GeV/c)^2 and W= 1.91GeV. Electroproduction on hydrogen was measured at the same kinematics for reference.

  4. 光学Sigma-Delta模数转换器的研究进展%Research and development of optical sigma-delta analog to digital converter

    Institute of Scientific and Technical Information of China (English)

    周雯; 王目光; 李博

    2012-01-01

    Optical analog to digital conversion techniques have been the developing trend of analog to digital converter(ADC) with high conversion rate and high bit accuracy in recent years. As a kind of optical ADC, optical Sigma-Delta ADC has distinguished advantages such as high conversion accuracy and simple analog circuitry. Basic principle of optical Sigma-Delta ADC is introduced. The structures of several typical optical Sigma-Delta ADCs are described detailedly.Finally the merits and demerits of optical Sigma-Delta ADCs with different structures are summed up.%采用光学模数转换技术已经成为高转换速率、高比特精度模数转换器(ADC)的发展趋势.光学Sigma-Delta ADC作为一种光学ADC,具有转换精度高和模拟电路简单等显著优点.介绍了光学Sigma-Delta ADC的基本原理,详细阐述了几种典型的光学Sigma-Delta ADC的系统结构,对不同结构的光学Sigma-Delta ADC的优缺点进行了归纳总结.

  5. The C-Terminal RpoN Domain of sigma54 Forms an unpredictedHelix-Turn-Helix Motif Similar to domains of sigma70

    Energy Technology Data Exchange (ETDEWEB)

    Doucleff, Michaeleen; Malak, Lawrence T.; Pelton, Jeffrey G.; Wemmer, David E.

    2005-11-01

    The ''{delta}'' subunit of prokaryotic RNA-polymerase allows gene-specific transcription initiation. Two {sigma} families have been identified, {sigma}{sup 70} and {sigma}{sup 54}, which use distinct mechanisms to initiate transcription and share no detectable sequence homology. Although the {sigma}{sup 70}-type factors have been well characterized structurally by x-ray crystallography, no high-resolution structural information is available for the {sigma}{sup 54}-type factors. Here we present the NMR derived structure of the C-terminal domain of {sigma}{sup 54} from Aquifex aeolicus. This domain (Thr323 to Gly389), which contains the highly conserved RpoN box sequence, consists of a poorly structured N-terminal tail followed by a three-helix bundle, which is surprisingly similar to domains of the {sigma}{sup 70}-type proteins. Residues of the RpoN box, which have previously been shown to be critical for DNA binding, form the second helix of an unpredicted helix-turn-helix motif. This structure's homology with other DNA binding proteins, combined with previous biochemical data, suggest how the C-terminal domain of {sigma}{sup 54} binds to DNA.

  6. Sigma-1 Receptor Imaging in the Brain : Cerebral sigma-1 receptors and cognition: Small-animal PET studies using 11C-SA4503

    NARCIS (Netherlands)

    Kuzhuppilly Ramakrishnan, Nisha

    2014-01-01

    The sigma-1 receptor is a unique orphan receptor, strongly expressed in neurons and glia. Sigma-1 receptors are involved in several central nervous system (CNS) disorders like depression, anxiety, psychosis, schizophrenia, Parkinson’s disease, Alzheimer’s disease, addiction and neuropathic pain. Sev

  7. First Observation of the Cabibbo-suppressed Decays Xi_c+ -> Sigma+ pi- pi+ and Xi_c+ -> Sigma- pi+ pi+ and Measurement of their Branching Ratios

    CERN Document Server

    Vazquez-Jauregui, E

    2008-01-01

    We report the first observation of two Cabibbo-suppressed decay modes, Xi_c+ -> Sigma+ pi- pi+ and Xi_c+ -> Sigma- pi+ pi+. We observe 56+/-13 over a background of 21, and 23+/-7 over a background of 12 events, respectively, for the signals. The data were accumulated using the SELEX spectrometer during the 1996-1997 fixed target run at Fermilab, chiefly from a 600GeV/c Sigma- beam. The branching ratios of the decays relative to the Cabibbo--favored Xi_c+ -> Xi- pi+ pi+ are measured to be B(Xi_c+ -> Sigma+ pi- pi+)/B(Xi_c+ -> Xi- pi+ pi+) = 0.50+/-0.20, and B(Xi_c+ -> Sigma- pi+ pi+)/B(Xi_c+ -> Xi- pi+ pi+) = 0.23+/-0.11, respectively. We also report branching ratios for the same decay modes of the Lambda_c+ relative to Lambda_c+ -> p K- pi+.

  8. Ab initio potential curves for the X $^2\\Sigma_u^+$, A $^2\\Pi_u$ and B $^2\\Sigma_g^+$ states of Ca$_{2}^+$

    CERN Document Server

    Banerjee, Sandipan; Byrd, Jason N; Michels, H Harvey; Côté, Robin

    2014-01-01

    We report \\textit{ab initio} calculations of the X $^2 \\Sigma_{u}^+$, A $^2\\Pi_u$ and B $^2 \\Sigma_{g}^+$ states of the Ca$_{2}^+$ dimer. All electron CAS+MRCI calculations are performed for the X $^2 \\Sigma_{u}^+$ and B $^2 \\Sigma_{g}^+$ states, while valence CAS+MRCI calculations using an effective core potential are used to describe the A $^2\\Pi_u$ state. A double well is found in the B $^2 \\Sigma_{g}^+$ state. Spectroscopic constants, vibrational levels, transition moments and radiative lifetimes are calculated for the most abundant isotope of calcium ($^{40}$Ca). The static dipole and quadrupole polarizabilities, and the leading order van der Waals coefficients are also calculated for all three states.

  9. Dependencia de la Temperatura de Compensaci\\'on en Modelos de Multicapas Ferrimagn\\'eticas de tipo $3(S_{1-x} \\sigma_x)/\\sigma$

    CERN Document Server

    Dalmagro, F A

    2013-01-01

    We investigate numerically the behavior of the compensation temperature, $T_{comp}$, in ferrimagnetic multilayer in the type $3(S_{1-x} \\sigma_x)/\\sigma$ with respect to the increase of the spin concentration $\\sigma_x$, which are randomly distributive in a mix of spins $S = 0, \\pm 1$ and $\\sigma = \\pm 1/2$, with ferromagnetic interaction between spins of the same type, and antiferromagnetic interaction for spins of different type. We have found that $T_{comp}$ decrease slowly with the increase of $x$, until $\\sigma_x$ represent a little more than 40\\% of the spin mixture. For higher concentration values $T_{comp}$ drops abruptly and disappears, as predicted by experimental result.

  10. A polymerase chain reaction-based approach to cloning sigma factors from eubacteria and its application to the isolation of a sigma-70 homolog from Chlamydia trachomatis.

    Science.gov (United States)

    Engel, J N; Ganem, D

    1990-05-01

    Taking advantage of the known sequence conservation of portions of bacterial sigma factor proteins, we have designed degenerate oligonucleotides corresponding to these domains and used these synthetic DNA sequences as primers in a polymerase chain reaction (PCR) to amplify DNA sequences from the chlamydial genome. The PCR products were used as a probe to recover the genomic fragments from a library of cloned murine Chlamydia trachomatis DNA. Sequence analysis of one of these clones revealed striking homology to the sigma-70 protein of Escherichia coli and the sigma-43 protein of Bacillus subtilis, strongly implying that this locus (sigA) encodes the major vegetative sigma factor of murine C. trachomatis. This PCR-based approach will be broadly applicable to the cloning of major sigma factors from other eubacteria.

  11. Pathway-specific profiling identifies the NF-kappa B-dependent tumor necrosis factor alpha-regulated genes in epidermal keratinocytes.

    Science.gov (United States)

    Banno, Tomohiro; Gazel, Alix; Blumenberg, Miroslav

    2005-05-13

    Identification of tumor necrosis factor alpha (TNF alpha) as the key agent in inflammatory disorders led to new therapies specifically targeting TNF alpha and avoiding many side effects of earlier anti-inflammatory drugs. However, because of the wide spectrum of systems affected by TNF alpha, drugs targeting TNF alpha have a potential risk of delaying wound healing, secondary infections, and cancer. Indeed, increased risks of tuberculosis and carcinogenesis have been reported as side effects after anti-TNF alpha therapy. TNF alpha regulates many processes (e.g. immune response, cell cycle, and apoptosis) through several signal transduction pathways that convey the TNF alpha signals to the nucleus. Hypothesizing that specific TNF alpha-dependent pathways control specific processes and that inhibition of a specific pathway may yield even more precisely targeted therapies, we used oligonucleotide microarrays and parthenolide, an NF-kappa B-specific inhibitor, to identify the NF-kappa B-dependent set of the TNF alpha-regulated genes in human epidermal keratinocytes. Expression of approximately 40% of all TNF alpha-regulated genes depends on NF-kappa B; 17% are regulated early (1-4 h post-treatment), and 23% are regulated late (24-48 h). Cytokines and apoptosis-related and cornification proteins belong to the "early" NF-kappa B-dependent group, and antigen presentation proteins belong to the "late" group, whereas most cell cycle, RNA-processing, and metabolic enzymes are not NF-kappa B-dependent. Therefore, inflammation, immunomodulation, apoptosis, and differentiation are on the NF-kappa B pathway, and cell cycle, metabolism, and RNA processing are not. Most early genes contain consensus NF-kappaB binding sites in their promoter DNA and are, presumably, directly regulated by NF-kappa B, except, curiously, the cornification markers. Using siRNA silencing, we identified cFLIP/CFLAR as an essential NF-kappa B-dependent antiapoptotic gene. The results confirm our

  12. Staphylococcus aureus shifts towards commensalism in response to Corynebacterium species

    Directory of Open Access Journals (Sweden)

    Matthew M Ramsey

    2016-08-01

    Full Text Available Staphylococcus aureus–human interactions result in a continuum of outcomes from commensalism to pathogenesis. S. aureus is a clinically important pathogen that asymptomatically colonizes ~25% of humans as a member of the nostril and skin microbiota, where it resides with other bacteria including commensal Corynebacterium species. Commensal Corynebacterium spp. are also positively correlated with S. aureus in chronic polymicrobial diabetic foot infections, distinct from acute monomicrobial S. aureus infections. Recent work by our lab and others indicates that microbe-microbe interactions between S. aureus and human skin/nasal commensals, including Corynebacterium species, affect S. aureus behavior and fitness. Thus, we hypothesized that S. aureus interactions with Corynebacterium spp. diminish S. aureus virulence. We tested this by assaying for changes in S. aureus gene expression during in vitro mono- versus coculture with Corynebacterium striatum, a common skin and nasal commensal. We observed a broad shift in S. aureus gene transcription during in vitro growth with C. striatum, including increased transcription of genes known to exhibit increased expression during human nasal colonization and decreased transcription of virulence genes. S. aureus uses several regulatory pathways to transition between commensal and pathogenic states. One of these, the quorum signal accessory gene regulator (agr system, was strongly inhibited in response to Corynebacterium spp. Phenotypically, S. aureus exposed to C. striatum exhibited increased adhesion to epithelial cells, reflecting a commensal state, and decreased hemolysin activity, reflecting an attenuation of virulence. Consistent with this, S. aureus displayed diminished fitness in experimental in vivo coinfection with C. striatum when compared to monoinfection. These data support a model in which S. aureus shifts from virulence towards a commensal state when exposed to commensal Corynebacterium species.

  13. Development and initial test of the University of Wisconsin global isentropic-sigma model

    Science.gov (United States)

    Zapotocny, Tom H.; Johnson, Donald R.; Reames, Fred M.

    1994-01-01

    The description of a global version of the University of Wisconsin (UW) hybrid isentropic-sigma (theta-sigma) model and the results from an initial numerical weather prediction experiment are presented in this paper. The main objectives of this initial test are to (1) discuss theta-sigma model development and computer requirements, (2) demonstrate the ability of the UW theta-sigma model for global numerical weather prediction using realistic orography and parameterized physical processes, and (3) compare the transport of an inert trace constituent against a nominally 'identical' sigma coordinate model. Initial and verifying data for the 5-day simulations presented in this work were supplied by the Goddard Earth Observing System (GEOS-1) data assimilation system. The time period studied is 1-6 February 1985. This validation experiment demonstrates that the global UW theta-sigma model produces a realistic 5-day simulation of the mass and momentum distributions when compared to both the identical sigma model and GEOS-1 verification. Root-mean-square errors demonstrate that the theta-sigma model is slightly more accurate than the nominally identical sigma model with respect to standard synoptic variables. Of particular importance, the UW theta-sigma model displays a distinct advantage over the conventional sigma model with respect to the prognostic simulation of inert trace constituent transport in amplifying baroclinic waves of the extratropics. This is especially true in the upper troposphere and stratosphere where the spatial integrity and conservation of an inert trace constituent is severely compromised in the sigma model compared to the theta-sigma model.

  14. A full-length group 1 bacterial sigma factor adopts a compact structure incompatible with DNA binding.

    Science.gov (United States)

    Schwartz, Edmund C; Shekhtman, Alexander; Dutta, Kaushik; Pratt, Matthew R; Cowburn, David; Darst, Seth; Muir, Tom W

    2008-10-20

    The sigma factors are the key regulators of bacterial transcription initiation. Through direct read-out of promoter DNA sequence, they recruit the core RNA polymerase to sites of initiation, thereby dictating the RNA polymerase promoter-specificity. The group 1 sigma factors, which direct the vast majority of transcription initiation during log phase growth and are essential for viability, are autoregulated by an N-terminal sequence known as sigma1.1. We report the solution structure of Thermotoga maritima sigmaA sigma1.1. We additionally demonstrate by using chemical crosslinking strategies that sigma1.1 is in close proximity to the promoter recognition domains of sigmaA. We therefore propose that sigma1.1 autoinhibits promoter DNA binding of free sigmaA by stabilizing a compact organization of the sigma factor domains that is unable to bind DNA.

  15. Aspartate inhibits Staphylococcus aureus biofilm formation.

    Science.gov (United States)

    Yang, Hang; Wang, Mengyue; Yu, Junping; Wei, Hongping

    2015-04-01

    Biofilm formation renders Staphylococcus aureus highly resistant to conventional antibiotics and host defenses. Four D-amino acids (D-Leu, D-Met, D-Trp and D-Tyr) have been reported to be able to inhibit biofilm formation and disassemble established S. aureus biofilms. We report here for the first time that both D- and L-isoforms of aspartate (Asp) inhibited S. aureus biofilm formation on tissue culture plates. Similar biofilm inhibition effects were also observed against other staphylococcal strains, including S. saprophyticus, S. equorum, S. chromogenes and S. haemolyticus. It was found that Asp at high concentrations (>10 mM) inhibited the growth of planktonic N315 cells, but at subinhibitory concentrations decreased the cellular metabolic activity without influencing cell growth. The decreased cellular metabolic activity might be the reason for the production of less protein and DNA in the matrix of the biofilms formed in the presence of Asp. However, varied inhibition efficacies of Asp were observed for biofilms formed by clinical staphylococcal isolates. There might be mechanisms other than decreasing the metabolic activity, e.g. the biofilm phenotypes, affecting biofilm formation in the presence of Asp.

  16. Toxin-Antitoxin Systems of Staphylococcus aureus

    Directory of Open Access Journals (Sweden)

    Christopher F. Schuster

    2016-05-01

    Full Text Available Toxin-antitoxin (TA systems are small genetic elements found in the majority of prokaryotes. They encode toxin proteins that interfere with vital cellular functions and are counteracted by antitoxins. Dependent on the chemical nature of the antitoxins (protein or RNA and how they control the activity of the toxin, TA systems are currently divided into six different types. Genes comprising the TA types I, II and III have been identified in Staphylococcus aureus. MazF, the toxin of the mazEF locus is a sequence-specific RNase that cleaves a number of transcripts, including those encoding pathogenicity factors. Two yefM-yoeB paralogs represent two independent, but auto-regulated TA systems that give rise to ribosome-dependent RNases. In addition, omega/epsilon/zeta constitutes a tripartite TA system that supposedly plays a role in the stabilization of resistance factors. The SprA1/SprA1AS and SprF1/SprG1 systems are post-transcriptionally regulated by RNA antitoxins and encode small membrane damaging proteins. TA systems controlled by interaction between toxin protein and antitoxin RNA have been identified in S. aureus in silico, but not yet experimentally proven. A closer inspection of possible links between TA systems and S. aureus pathophysiology will reveal, if these genetic loci may represent druggable targets. The modification of a staphylococcal TA toxin to a cyclopeptide antibiotic highlights the potential of TA systems as rather untapped sources of drug discovery.

  17. Toxin-Antitoxin Systems of Staphylococcus aureus.

    Science.gov (United States)

    Schuster, Christopher F; Bertram, Ralph

    2016-05-05

    Toxin-antitoxin (TA) systems are small genetic elements found in the majority of prokaryotes. They encode toxin proteins that interfere with vital cellular functions and are counteracted by antitoxins. Dependent on the chemical nature of the antitoxins (protein or RNA) and how they control the activity of the toxin, TA systems are currently divided into six different types. Genes comprising the TA types I, II and III have been identified in Staphylococcus aureus. MazF, the toxin of the mazEF locus is a sequence-specific RNase that cleaves a number of transcripts, including those encoding pathogenicity factors. Two yefM-yoeB paralogs represent two independent, but auto-regulated TA systems that give rise to ribosome-dependent RNases. In addition, omega/epsilon/zeta constitutes a tripartite TA system that supposedly plays a role in the stabilization of resistance factors. The SprA1/SprA1AS and SprF1/SprG1 systems are post-transcriptionally regulated by RNA antitoxins and encode small membrane damaging proteins. TA systems controlled by interaction between toxin protein and antitoxin RNA have been identified in S. aureus in silico, but not yet experimentally proven. A closer inspection of possible links between TA systems and S. aureus pathophysiology will reveal, if these genetic loci may represent druggable targets. The modification of a staphylococcal TA toxin to a cyclopeptide antibiotic highlights the potential of TA systems as rather untapped sources of drug discovery.

  18. NVC-422 inactivates Staphylococcus aureus toxins.

    Science.gov (United States)

    Jekle, Andreas; Yoon, Jungjoo; Zuck, Meghan; Najafi, Ramin; Wang, Lu; Shiau, Timothy; Francavilla, Charles; Rani, Suriani Abdul; Eitzinger, Christian; Nagl, Markus; Anderson, Mark; Debabov, Dmitri

    2013-02-01

    Bacterial pathogens have specific virulence factors (e.g., toxins) that contribute significantly to the virulence and infectivity of microorganisms within the human hosts. Virulence factors are molecules expressed by pathogens that enable colonization, immunoevasion, and immunosuppression, obtaining nutrients from the host or gaining entry into host cells. They can cause pathogenesis by inhibiting or stimulating certain host functions. For example, in systemic Staphylococcus aureus infections, virulence factors such as toxic shock syndrome toxin 1 (TSST-1), staphylococcal enterotoxin A (SEA), and staphylococcal enterotoxin B (SEB) cause sepsis or toxic shock by uncontrolled stimulation of T lymphocytes and by triggering a cytokine storm. In vitro, these superantigens stimulate the proliferation of human peripheral blood mononuclear cells (PBMC) and the release of many cytokines. NVC-422 (N,N-dichloro-2,2-dimethyltaurine) is a broad-spectrum, fast-acting topical anti-infective agent against microbial pathogens, including antibiotic-resistant microbes. Using mass spectrometry, we demonstrate here that NVC-422 oxidizes methionine residues of TSST-1, SEA, SEB, and exfoliative toxin A (ETA). Exposure of virulence factors to 0.1% NVC-422 for 1 h prevented TSST-1-, SEA-, SEB-, and ETA-induced cell proliferation and cytokine release. Moreover, NVC-422 also delayed and reduced the protein A- and clumping factor-associated agglutination of S. aureus cultures. These results show that, in addition to its well-described direct microbicidal activity, NVC-422 can inactivate S. aureus virulence factors through rapid oxidation of methionines.

  19. Improvement of Production Quality by using Six Sigma Technique:

    Directory of Open Access Journals (Sweden)

    Sawsan Ali

    2013-04-01

    Full Text Available As a result of lack of conformity of the outer diameter of the filling piston of plastic syringe to the specifications set out in the design map and the increased demand for its  products from the Medical syringes factory – Babylon. The research conducts the necessary investigations and  analysis of the production process as most of the units rejected by fact that the outer diameter of the filling piston is smaller than the minimum specification and units returned to work  due to the fact that  the outer diameter larger than the upper limit of the specification.13The research aims firstly to examine the outer diameter of the filling piston through the use of the control chart of the variables represented by the average , and its impact on the production process capability because the increase in diameter specification leads to an increase in the pressure imposed on the lining of the cylinder, causing difficulty in piston movement and a decrease in diameter specification which leads to loose the process capability to prevent leakage of fluid, causing air to enter as well as to speed the movement of the piston, which negatively affects human life in both cases. Secondly, study the possibility of improving the production process capability by using advanced levels of the sigma.The results showed that the production process in the case of a disciplined and follows a normal distribution, the pointer of  the production process capability is equal to (0.55 and the factory works within the level of Sigma equal to (1.65. The proportion of a damaged product is (15.8 % and rework (0.99 %.In order to  reduce the proportion of damaged product, this paper introduces a quality plan depending on ( ±0.025 as tolerance limits instead of ( ±0.05 to increase sigma level by 202%.

  20. Naval Surface Warfare Center Dahlgren Division: Application of Lean Six Sigma in the Pre-Award Procurement Process

    Science.gov (United States)

    2008-09-01

    This Project outlines Lean Six Sigma principles, provides examples of Lean Six Sigma events, and analyzes principles that can be applied to Navy...acquisition and contracting. The objectives of this project are as follows: (1) provide an overview of Lean Six Sigma principles in contracting and...acquisition; (2) identify Navy contracting processes that have and can be analyzed using Lean Six Sigma principles; (3) explore how Lean Six Sigma can be

  1. Naval Surface Warfare Center Dahlgren Division: application of Lean Six Sigma in the pre-award procurement process

    OpenAIRE

    Himes, Kristy M.; Salisbury, Constance M.

    2008-01-01

    Joint Applied Project This Project outlines Lean Six Sigma principles, provides examples of Lean Six Sigma events, and analyzes principles that can be applied to Navy acquisition and contracting. The objective of this project is to: (1) provide an overview of Lean Six Sigma principles in contracting and acquisition; (2) identify Navy contracting processes that have and can be analyzed using Lean Six Sigma principles; (3) explore how Lean Six Sigma can be applied to interpret and implem...

  2. Six Sigma: not for the faint of heart.

    Science.gov (United States)

    Benedetto, Anthony R

    2003-01-01

    Six Sigma is an excellent quality and performance improvement tool. Like any tool, the results of using it are highly dependent on whether you use it with competence and on the right problem. This article will help you decide if your problem is well-suited for a Six Sigma approach and will suggest the optimum approach for planning and implementing Six Sigma methodology. Performance improvement methods can be grouped into two broad categories, based on the problem to be addressed. When the problem is relatively minor and localized, "evolutionary" methods may be suitable (e.g., quality circles, problem-solving staff meetings, continuous quality improvement [CQI], total quality management [TQM]). These tools work best when modest incremental improvements are sought, when major process redesign is not thought to be necessary, and when the avoidance of workplace disruption is desired. Reengineering and Six Sigma are the best-known examples of the "revolutionary" performance improvement methods. These methods should be used when major (drastic, do or die, etc.) improvements are needed. Problems that cross departmental boundaries need these methods. When a process is so dysfunctional that you feel like you need to tear up the standard operating procedure (SOP) and start all over again, you need a revolutionary method. A Six Sigma project requires a major expenditure of money and employee time, and a willingness to make some hard decisions about jobs, employee retention and relationships among stakeholders. An institution's culture should be considered as part of the decision about using Six Sigma. If the institution has a history of making data-driven decisions, or at least has displayed openness to operating in that manner, Six Sigma has a good chance of success. A radiology-driven Six Sigma project should not be undertaken until a comprehensive written description of the scope of the project is approved by the radiology department leadership team and by the appropriate

  3. Winding vacuum energies in a deformed O(4) sigma model

    CERN Document Server

    Bazhanov, Vladimir V; Lukyanov, Sergei L

    2014-01-01

    We consider the problem of calculating the Casimir energies in the winding sectors of Fateev's SS-model, which is an integrable two-parameter deformation of the O(4) non-linear sigma model in two dimensions. This problem lies beyond the scope of all traditional methods of integrable quantum field theory including the thermodynamic Bethe ansatz and non-linear integral equations. Here we propose a solution based on a remarkable correspondence between classical and quantum integrable systems and express the winding energies in terms of certain solutions of the classical sinh-Gordon equation.

  4. Comparing Poisson Sigma Model with A-model

    CERN Document Server

    Bonechi, Francesco; Iraso, Riccardo

    2016-01-01

    We discuss the A-model as a gauge fixing of the Poisson Sigma Model with target a symplectic structure. We complete the discussion in [arXiv:0706.3164], where a gauge fixing defined by a compatible complex structure was introduced, by showing how to recover the A-model hierarchy of observables in terms of the AKSZ observables. Moreover, we discuss the off-shell supersymmetry of the A-model as a residual BV symmetry of the gauge-fixed PSM action.

  5. Pion Effect of Nuclear Matter in a Chiral Sigma Model

    Institute of Scientific and Technical Information of China (English)

    HU Jin-niu; Y.Ogawa; H.Toki; A.Hosaka; SHEN Hong

    2009-01-01

    We develop a new framework for the study of the nuclear matter based on the linear sigma model.We introduce a completely new viewpoint on the treatment of the nuclear matter with the inclusion of the pion.We extend the relativistic chiral mean field model by using the similar method in the tensor optimized shell model.We also regulate the pion-nucleon interaction by considering the form-factor and short range repulsion effects.We obtain the equation of state of nuclear matter and study the importance of the pion effect.

  6. Winding vacuum energies in a deformed O(4) sigma model

    Energy Technology Data Exchange (ETDEWEB)

    Bazhanov, Vladimir V. [Department of Theoretical Physics, Research School of Physics and Engineering, Australian National University, Canberra, ACT 0200 (Australia); Mathematical Sciences Institute, Australian National University, Canberra, ACT 0200 (Australia); Kotousov, Gleb A. [Department of Theoretical Physics, Research School of Physics and Engineering, Australian National University, Canberra, ACT 0200 (Australia); Lukyanov, Sergei L., E-mail: sergei@physics.rutgers.edu [NHETC, Department of Physics and Astronomy, Rutgers University, Piscataway, NJ 08855-0849 (United States); L.D. Landau Institute for Theoretical Physics, Chernogolovka 142432 (Russian Federation)

    2014-12-15

    We consider the problem of calculating the Casimir energies in the winding sectors of Fateev's SS-model, which is an integrable two-parameter deformation of the O(4) non-linear sigma model in two dimensions. This problem lies beyond the scope of all traditional methods of integrable quantum field theory including the thermodynamic Bethe ansatz and non-linear integral equations. Here we propose a solution based on a remarkable correspondence between classical and quantum integrable systems and express the winding energies in terms of certain solutions of the classical sinh-Gordon equation.

  7. Can sigma models describe finite temperature chiral transitions?

    CERN Document Server

    Kocic, Aleksandar; Aleksandar KOCIC; John KOGUT

    1995-01-01

    Large-N expansions and computer simulations indicate that the universality class of the finite temperature chiral symmetry restoration transition in the 3D Gross-Neveu model is mean field theory. This is a counterexample to the standard 'sigma model' scenario which predicts the 2D Ising model universality class. We trace the breakdown of the standard scenario (dimensional reduction and universality) to the absence of canonical scalar fields in the model. We point out that our results could be generic for theories with dynamical symmetry breaking, such as Quantum Chromodynamics.

  8. Zur Situation gehörloser Menschen im Alter (SIGMA)

    OpenAIRE

    Kaul, Thomas; Gelhardt, Anne; Klinner, Susanne; Menzel, Frank

    2009-01-01

    In dem Projekt SIGMA wurden im Auftrag des Bundesministeriums für Familie, Senioren, Frauen und Jugend erstmals aus der Perspektive gehörloser Menschen im Alter ihre individuellen Ressourcen sowie die Qualität und Quantität von Angeboten und Maßnahmen der Altenhilfe erforscht. Zwischen 2006 und 2009 wurden u.a. mehr als 200 gehörlose Menschen über 55 Jahre zu ihren spezifischen Lebensbedingungen und Lebensvorstellungen interviewt. Darüber hinaus wurden auch Experten zu der Versorgungssituatio...

  9. Complex structure-induced deformations of sigma-models

    CERN Document Server

    Bykov, Dmitri

    2016-01-01

    We describe a deformation of the principal chiral model (with an even-dimensional target space G) by a B-field proportional to the K\\"ahler form on the target space. The equations of motion of the deformed model admit a zero-curvature representation. As a simplest example, we consider the case of G=S^1 x S^3. We also apply a variant of the construction to a deformation of the AdS_3 x S^3 x S^1 (super-)sigma-model.

  10. A calculation of the physical mass of sigma meson

    Indian Academy of Sciences (India)

    J R Morones-Ibarra; Ayax Santos-Guevara

    2007-06-01

    We calculate the physical mass and the width of the sigma meson by considering that it couples in vacuum to two virtual pions. The mass is calculated by using the spectral function, and we find that it is about 600 MeV. In addition, we obtained 220 MeV as the value for the width of its spectral function. The value obtained for the mass is in good agreement with that reported in the Particle Data Book for the σ-meson, which is also named 0(600). This result also shows that -meson can be considered as a two-pion resonance.

  11. A framework to a mass dimension one fermionic sigma model

    CERN Document Server

    Rogerio, R J Bueno; Pereira, S H; da Rocha, Roldao

    2016-01-01

    In this paper a mass dimension one fermionic sigma model, realized by the eigenspinors of the charge conjugation operator with dual helicity (Elko spinors), is developed. Such spinors are chosen as a specific realization of mass dimension one spinors, wherein the non-commutative fermionic feature is ruled by torsion. Moreover, we analyse Elko spinors as a source of matter in a background in expansion. Moreover, we analyse Elko spinors as a source of matter in a background in expansion and we have found that such kind of mass dimension one fermions can serve not only as dark matter but they also induce an effective cosmological constant.

  12. Investigation of $\\eta'N$ system using linear sigma model

    CERN Document Server

    Sakai, Shuntaro

    2016-01-01

    In this paper, we investigate the $\\eta'N$ system using the three-flavor linear sigma model including the effect of the flavor SU(3) symmetry breaking. The $\\eta'N$ bound state is found also in the case including the flavor symmetry braking and the coupling with the $\\eta N$ and $\\pi N$ channels. The $\\eta'N$ interaction becomes more attractive with the inclusion of the flavor symmetry breaking which causes the mixing between the singlet and octet scalar mesons. The existence of such a bound state would have some impact on the $\\eta'$-nucleus system, which is of interest from the theoretical and experimental viewpoint.

  13. A Dynamical Resolution of the Sigma Term Puzzle

    CERN Document Server

    Ball, R D; Tigg, J; Ball, Richard D.; Forte, Stefano; Tigg, Jason

    1994-01-01

    We propose a resolution of the puzzle posed by the discrepancy between the pion-nucleon sigma term inferred from pion-nucleon scattering, and that deduced from baryon mass splittings using the Zweig rule. We show that there is a significant hypercharge-dependent dynamical contribution to baryon masses, not hitherto included in the analysis, which may be estimated using the scale Ward identity, and computed by solution of the Schwinger-Dyson equation for the quark self-energy. We find that the discrepancy is completely resolved without the need for any Zweig rule violation.

  14. Integrable deformations of T-dual $\\sigma$ models

    CERN Document Server

    Borsato, Riccardo

    2016-01-01

    We present a method to deform (generically non-abelian) T duals of two-dimensional $\\sigma$ models, which preserves classical integrability. The deformed models are identified by a linear operator $\\omega$ on the dualised subalgebra, which satisfies the 2-cocycle condition. We prove that the so-called homogeneous Yang-Baxter deformations are equivalent, via a field redefinition, to our deformed models when $\\omega$ is invertible. We explain the details for deformations of T duals of Principal Chiral Models, and present the corresponding generalisation to the case of supercoset models.

  15. On the Chiral Phase Transition in the Linear Sigma Model

    CERN Document Server

    Phat, T H; Hoa, L V; Phat, Tran Huu; Anh, Nguyen Tuan; Hoa, Le Viet

    2004-01-01

    The Cornwall-Jackiw-Tomboulis (CJT) effective action for composite operators at finite temperature is used to investigate the chiral phase transition within the framework of the linear sigma model as the low-energy effective model of quantum chromodynamics (QCD). A new renormalization prescription for the CJT effective action in the Hartree-Fock (HF) approximation is proposed. A numerical study, which incorporates both thermal and quantum effect, shows that in this approximation the phase transition is of first order. However, taking into account the higher-loop diagrams contribution the order of phase transition is unchanged.

  16. 12位Sigma-Delta模数转换器的降采样滤波器设计%Decimation Filter Design for 12-bit Sigma-Delta ADC

    Institute of Scientific and Technical Information of China (English)

    黄博志

    2014-01-01

    The paper presents a signal-noise-ratio (SNR) based design method for the decimation filter of a 12-bit Sigma-Delta ADC (analog-to-digital converter). Sigma-Delta ADC consists of Sigma-Delta modulatorand decimation filter. Sigma-Delta modulatoris used for signal modulation and over-sampling quantization. Decimation filter is used for down-sampling the digital signal to its normal frequency and the quantization noise is filtered at the same time. Sigma-Delta ADC has higher sampling frequency, higher precision and less hardware cost than traditional ADC. There are two specifications for decimation filter:down-sampling rate and filter performance. This filter design method is driven by SNR and two solutions are applied. Simulation is done using MATLAB and the result is met the requirement of 12-bit Sigma-Delta ADC with SNR larger than 74 dB.%一种由SNR(信噪比)驱动的滤波器设计,用于12位Sigma-Delta模数转换器。Sigma-Delta模数转换器包括Sigma-Delta调制器和降采样滤波器两部分,首先用Sigma-Delta调制器对信号进行过采样率量化,然后通过降采样滤波器进行数字信号处理,将信号还原到原始采样率并去除量化噪声。和传统的模数转换器相比,Sigma-Delta模数转换器具有采样率高、精度高、面积小等优点。Sigma-Delta模数转换器的滤波器设计有降采样率和滤波性能两个指标要求,该设计方法由SNR驱动并采用了两种滤波器方案,设计结果在MATLAB里进行了仿真,其SNR大于74 dB,达到12位Sigma-Delta模数转换器的要求。

  17. SAMMD: Staphylococcus aureus Microarray Meta-Database

    Directory of Open Access Journals (Sweden)

    Elasri Mohamed O

    2007-10-01

    Full Text Available Abstract Background Staphylococcus aureus is an important human pathogen, causing a wide variety of diseases ranging from superficial skin infections to severe life threatening infections. S. aureus is one of the leading causes of nosocomial infections. Its ability to resist multiple antibiotics poses a growing public health problem. In order to understand the mechanism of pathogenesis of S. aureus, several global expression profiles have been developed. These transcriptional profiles included regulatory mutants of S. aureus and growth of wild type under different growth conditions. The abundance of these profiles has generated a large amount of data without a uniform annotation system to comprehensively examine them. We report the development of the Staphylococcus aureus Microarray meta-database (SAMMD which includes data from all the published transcriptional profiles. SAMMD is a web-accessible database that helps users to perform a variety of analysis against and within the existing transcriptional profiles. Description SAMMD is a relational database that uses MySQL as the back end and PHP/JavaScript/DHTML as the front end. The database is normalized and consists of five tables, which holds information about gene annotations, regulated gene lists, experimental details, references, and other details. SAMMD data is collected from the peer-reviewed published articles. Data extraction and conversion was done using perl scripts while data entry was done through phpMyAdmin tool. The database is accessible via a web interface that contains several features such as a simple search by ORF ID, gene name, gene product name, advanced search using gene lists, comparing among datasets, browsing, downloading, statistics, and help. The database is licensed under General Public License (GPL. Conclusion SAMMD is hosted and available at http://www.bioinformatics.org/sammd/. Currently there are over 9500 entries for regulated genes, from 67 microarray

  18. Protein kinase Cmu downregulation of tumor-necrosis-factor-induced apoptosis correlates with enhanced expression of nuclear-factor-kappaB-dependent protective genes.

    Science.gov (United States)

    Johannes, F J; Horn, J; Link, G; Haas, E; Siemienski, K; Wajant, H; Pfizenmaier, K

    1998-10-01

    Protein kinase Cmu (PKCmu) represents a new subtype of the PKC family characterized by the presence of a pleckstrin homology (PH) domain and an amino-terminal hydrophobic region. In order to analyse the potential role of PKCmu in signal-transduction pathways, stable PKCmu transfectants were established with human and murine cell lines. All transfectants showed a reduced sensitivity to tumor-necrosis-factor (TNF)-induced apoptosis, which correlated with the amount of transgene expressed and with an enhanced basal transcription rate of NF-kappaB-driven genes including the inhibitor of apoptosis protein 2 (cIAP2) and TNF-receptor-associated protein 1 (TRAF1). Sensitivity to apoptosis induced by the lipid mediator ceramide was unchanged in PKCmu transfectants. In support of a PKCmu action on NF-kappaB, we show enhancement and downregulation of TNF-induced expression of a NF-kappaB-dependent reporter gene by transient overexpression of wild-type and kinase-negative mutants of PKCmu, respectively. Interestingly, no significant changes were found in an electrophoretic mobility shift assay, indicative of PKCmu action downstream of IkappaB degradation, probably by modulation of the transactivation capacity of NF-kappaB. The dominant negative action of the kinase-negative mutant further suggest a regulatory role of PKCmu for NF-kappaB-dependent gene expression.

  19. Bacillithiol: a key protective thiol in Staphylococcus aureus.

    Science.gov (United States)

    Perera, Varahenage R; Newton, Gerald L; Pogliano, Kit

    2015-01-01

    Bacillithiol is a low-molecular-weight thiol analogous to glutathione and is found in several Firmicutes, including Staphylococcus aureus. Since its discovery in 2009, bacillithiol has been a topic of interest because it has been found to contribute to resistance during oxidative stress and detoxification of electrophiles, such as the antibiotic fosfomycin, in S. aureus. The rapid increase in resistance of methicillin-resistant Staphylococcus aureus (MRSA) to available therapeutic agents is a great health concern, and many research efforts are focused on identifying new drugs and targets to combat this organism. This review describes the discovery of bacillithiol, studies that have elucidated the physiological roles of this molecule in S. aureus and other Bacilli, and the contribution of bacillithiol to S. aureus fitness during pathogenesis. Additionally, the bacillithiol biosynthesis pathway is evaluated as a novel drug target that can be utilized in combination with existing therapies to treat S. aureus infections.

  20. Some Practical Issues in the Application of Lean Six Sigma to Service Systems

    Directory of Open Access Journals (Sweden)

    Goh Thong-Ngee

    2014-11-01

    Full Text Available Six Sigma as a quality improvement framework has gained considerable popularity in the past two decades. Its extension Lean Six Sigma has also been embraced by many organizations for improvement of quality and business competitiveness. One important factor for the popularity of Six Sigma and Lean Six Sigma is their potential for improving service systems, in contrast to the conventional perceptions that only manufacturing systems can benefit from statistics-based methodologies. There are however a number of issues related to the nature of service systems that must be resolved before the full benefits of Lean Six Sigma can be realized. In this paper, these issues are discussed from a practical point of view from three angles: analytical, organizational, and personal. Awareness of the existence of such issues, if not the answers to all of them, is a pre-requisite to effective adoption of Lean Six Sigma tools.

  1. Magnetic Feshbach resonances in collisions of closed-shell $^1\\Sigma$ molecules

    CERN Document Server

    Wallis, Alisdair O G

    2012-01-01

    Magnetic Feshbach resonances play a central role in experimental research of atomic gases at ultracold temperatures. A major thrust of current research is to create an ultracold gas of diatomic alkali-metal molecules in the ground rovibrational state of the ground electronic $^1\\Sigma$ state. Can ultracold $^1\\Sigma$ molecules be controlled by means of magnetic Feshbach resonances? Unlike alkali metal atoms, $^1\\Sigma$ diatomic molecules have no unpaired electrons. The response of $^1\\Sigma$ molecules to an external magnetic field is determined by the spin structure of the atomic nuclei. We present quantum scattering calculations illustrating that nuclear spin relaxation and Feshbach resonances in ultracold molecule-molecule collisions for $^1\\Sigma$ molecules in a magnetic field are highly probable. We show that certain Zeeman states of $^1\\Sigma$ molecules exhibit broad resonances and weak inelastic scattering, which makes these states ideal for experiments exploiting magnetic field control of ultracold mol...

  2. The sigma-1 receptor enhances brain plasticity and functional recovery after experimental stroke

    DEFF Research Database (Denmark)

    Ruscher, Karsten; Shamloo, Mehrdad; Rickhag, Karl Mattias

    2011-01-01

    in an enriched environment for two weeks after permanent middle cerebral artery occlusion, we found increased sigma-1 receptor expression in peri-infarct areas. Treatment of rats subjected to permanent or transient middle cerebral artery occlusion with 1-(3,4-dimethoxyphenethyl)-4-(3-phenylpropyl......)piperazine dihydrochloride, an agonist of the sigma-1 receptor, starting two days after injury, enhanced the recovery of lost sensorimotor function without decreasing infarct size. The sigma-1 receptor was found in the galactocerebroside enriched membrane microdomains of reactive astrocytes and in neurons. Sigma-1 receptor...... activation increased the levels of the synaptic protein neurabin and neurexin in membrane rafts in the peri-infarct area, while sigma-1 receptor silencing prevented sigma-1 receptor-mediated neurite outgrowth in primary cortical neuronal cultures. In astrocytic cultures, oxygen and glucose deprivation...

  3. The sigma receptor as a ligand-regulated auxiliary potassium channel subunit.

    Science.gov (United States)

    Aydar, Ebru; Palmer, Christopher P; Klyachko, Vitaly A; Jackson, Meyer B

    2002-04-25

    The sigma receptor is a novel protein that mediates the modulation of ion channels by psychotropic drugs through a unique transduction mechanism depending neither on G proteins nor protein phosphorylation. The present study investigated sigma receptor signal transduction by reconstituting responses in Xenopus oocytes. Sigma receptors modulated voltage-gated K+ channels (Kv1.4 or Kv1.5) in different ways in the presence and absence of ligands. Association between Kv1.4 channels and sigma receptors was demonstrated by coimmunoprecipitation. These results indicate a novel mechanism of signal transduction dependent on protein-protein interactions. Domain accessibility experiments suggested a structure for the sigma receptor with two cytoplasmic termini and two membrane-spanning segments. The ligand-independent effects on channels suggest that sigma receptors serve as auxiliary subunits to voltage-gated K+ channels with distinct functional interactions, depending on the presence or absence of ligand.

  4. Seis Sigma: Fatores Críticos de Sucesso para sua Implantação

    Directory of Open Access Journals (Sweden)

    Antonio Cesar Amaru Maximiano

    2009-10-01

    Full Text Available This article describes an investigation of critical success factors to implement Six Sigma in organizations operating in the Brazilian market place. Besides that, a secondary objective was to investigate the relationship between aspects like success perception among those companies which implemented Six Sigma, company size, company nationality, time of Six Sigma of implementation, continuous training, communication level between professionals, full-time and part-time Black Belts, project completion, project duration and project savings. Data were collected through an Internet questionnaire, distributed by email and sent to discussion groups involving Six Sigma professionals. Questionnaire development included a literature review and interviews with experienced Six Sigma professionals. The results indicated eight critical success factors for Six Sigma implementation: (a Leadership, (b Projects, (c Training, (d Communication and Review, (e Managerial Process, (f Black Belts Profile, (g Project Teams and (h Previous Quality Initiatives.

  5. Phagocytosis and Killing of Staphylococcus aureus by Human Neutrophils

    OpenAIRE

    Lu, Thea; Porter, Adeline R.; Kennedy, Adam D.; Kobayashi, Scott D.; Frank R DeLeo

    2014-01-01

    Neutrophils are essential for host defense against Staphylococcus aureus infections. Although significant progress has been made, our understanding of neutrophil interactions with S. aureus remains incomplete. To provide a more comprehensive view of this process, we investigated phagocytosis and killing of S. aureus by human neutrophils using varied assay conditions in vitro. A greater percentage of bacteria were internalized by adherent neutrophils compared to those in suspension, and unexpe...

  6. Sequences in sigma(54) region I required for binding to early melted DNA and their involvement in sigma-DNA isomerisation.

    Science.gov (United States)

    Gallegos, M T; Buck, M

    2000-04-07

    The bacterial sigma(54) RNA polymerase functions in a transcription activation mechanism that fully relies upon nucleotide hydrolysis by an enhancer binding activator protein to stimulate open complex formation. Here, we describe results of DNA-binding assays used to probe the role of the sigma(54) amino terminal region I in activation. Of the 15 region I alanine substitution mutants assayed, several specifically failed to bind to a DNA structure representing an early conformation in DNA melting. The same mutants are defective in activated transcription and in forming an isomerised sigma-DNA complex on the early opened DNA. The mechanism of activation may therefore require tight binding of sigma(54) to particular early melted DNA structures. Where mutant sigma(54) binding to early melted DNA was detected, activator-dependent isomerisation generally occurred as efficiently as with the wild-type protein, suggesting that certain region I sequences are largely uninvolved in sigma isomerisation. DNA-binding, sigma isomerisation and transcription activation assays allow formulation of a functional map of region I.

  7. An Innovative Requirements Solution: Combining Six Sigma KJ Language Data Analysis with Automated Content Analysis

    Science.gov (United States)

    2009-03-01

    2008 Carnegie Mellon University An Innovative Requirements Solution: Combining Six Sigma KJ Language Data Analysis with Automated Content...2. REPORT TYPE 3. DATES COVERED 00-00-2009 to 00-00-2009 4. TITLE AND SUBTITLE An Innovative Requirements Solution: Combining Six Sigma KJ...Prescribed by ANSI Std Z39-18 3 An Innovative Requirements Solution: Marrying Six Sigma KJ Analysis with Automation for Text Analysis and

  8. Use of the Six Sigma by the 500 Largent Companies in Portugal

    OpenAIRE

    Mendes da Conceição, Ana Cristina; Martins Ferreira Major, Maria João

    2011-01-01

    The Six Sigma had its genesis in big industrial companies that have implemented it as a tool for reducing defects. The initial success encouraged its application in other areas and we see today successful implementation in other sectors such as services, and within their own organizations in other areas beyond production, setting; this has contributed to Six Sigma being recognized as a new management model. In order to determine the extent to which Six Sigma is present in Portuguese companies...

  9. INTEGRATING SIX-SIGMA AND HEALTHCARE QUALITY IMPROVEMENT CIRCLES IN REDUCING THE NEEDLE STICKING

    OpenAIRE

    Sen-Ji Chen; Frank F. C. Pan; Hsuen C. H. Chen

    2008-01-01

    Six-Sigma (SS) is a managerial philosophy used in detecting the error rate of a particular (set) of activities. This research applies six sigma concepts in dealing with troublesome needle-stick events that occurred in a Taiwan hospital. This research integrates several advanced managerial instruments into one framework, grounded in Continuous Quality Improvement and Total Quality Management. This framework combines Six-Sigma and Health Quality Improvement circle practices. The project suggest...

  10. Retention of transcription initiation factor sigma(70) in transcription elongation: Single-molecule analysis

    OpenAIRE

    Kapanidis, A. N.; Margeat, E; Laurence, T A; Doose, S.; Ho, S O; Mukhopadhyay, J.; Kortkhonjia, E; Mekler, V; Ebright, R H; S. Weiss

    2005-01-01

    We report a single-molecule assay that defines, simultaneously, the translocational position of a protein complex relative to DNA and the subunit stoichiometry of the complex. We applied the assay to define translocational positions and sigma(70) contents of bacterial transcription elongation complexes in vitro. The results confirm ensemble results indicating that a large fraction, similar to 70%-90%, of early elongation complexes retain sigma(70) and that a determinant for sigma(70) recognit...

  11. On the role of the Escherichia coli RNA polymerase sigma factor in T4 phage development.

    Science.gov (United States)

    Zograff, Y N

    1981-01-01

    The rpoD800 mutation causing the temperature sensitivity of Escherichia coli RNA polymerase sigma factor has been used to demonstrate that the bacterial sigma factor is necessary throughout T4 phage development. In T4-infected RpoD800 mutant cells RNA synthesis is equally depressed at restrictive temperature at early and late stages of infection. The results show the bacterial sigma factor to be necessary for the synthesis of all RNA types in infected cells.

  12. SIX SIGMA, PERANGKAT MANAJERIAL PERUSAHAAN PADA ERA EKONOMI BARU (Sebuah Pendekatan Konseptual Terhadap Studi Literatur

    Directory of Open Access Journals (Sweden)

    Sugiono Sugiharto

    2004-01-01

    Full Text Available This study is directed to deepen the Sig Sigma conceptuals, as a very useful managerial instrument for every firm that needs competitive advantage in the era of new economy. Abstract in Bahasa Indonesia : Kajian ini diarahkan untuk mempelajari dengan seksama konsep-konsep yang terdapat di dalam Six Sigma, sebuah perangkat manajerial yang layak digunakan oleh setiap perusahaan yang ingin mendapatkan keunggulan bersaing di era ekonomi baru. Kata kunci: six sigma, perangkat manajerial, era ekonomi baru.

  13. Resistance in Staphylococcus Aureus: The Never-Ending Story

    Directory of Open Access Journals (Sweden)

    Orlović Jovan

    2016-09-01

    Full Text Available Combating Staphylococcus aureus (S. aureus infections using antibacterial drugs is actually an ongoing effort to overcome resistance mechanism of this microorganism. In this paper, we discussed (1 the mechanisms of resistance to some of the most commonly used antimicrobial agents in the treatment of S. aureus: methicillin, vancomicyn and quinolones. In addition, (2 efflux pump mechanisms involved in maintaining homeostasis in the presence of compounds that inhibit S. aureus growth and reproduction, as well as mechanisms of resistance to a number of antibiotics, have been reviewed.

  14. A porcine model of haematogenous brain infectionwith staphylococcus aureus

    DEFF Research Database (Denmark)

    Astrup, Lærke Boye; Agerholm, Jørgen Steen; Nielsen, Ole Lerberg;

    2012-01-01

    A PORCINE MODEL OF HAEMATOGENOUS BRAIN INFECTION WITH STAPHYLOCOCCUS AUREUS Astrup Lærke1, Agerholm Jørgen1, Nielsen Ole1, Jensen Henrik1, Leifsson Páll1, Iburg Tine2. 1: Faculty of Health and Medical Sciences, University of Copenhagen, Denmark boye@life.ku.dk 2: National Veterinary Institute......, Uppsala, Sweden Introduction Staphylococcus aureus (S.aureus) is a common cause of sepsis and brain abscesses in man and a frequent cause of porcine pyaemia. Here we present a porcine model of haematogenous S. aureus-induced brain infection. Materials and Methods Four pigs had two intravenous catheters...

  15. Phagocytosis and killing of Staphylococcus aureus by human neutrophils.

    Science.gov (United States)

    Lu, Thea; Porter, Adeline R; Kennedy, Adam D; Kobayashi, Scott D; DeLeo, Frank R

    2014-01-01

    Neutrophils are essential for host defense against Staphylococcus aureus infections. Although significant progress has been made, our understanding of neutrophil interactions with S. aureus remains incomplete. To provide a more comprehensive view of this process, we investigated phagocytosis and killing of S. aureus by human neutrophils using varied assay conditions in vitro. A greater percentage of bacteria were internalized by adherent neutrophils compared to those in suspension, and, unexpectedly, uptake of S. aureus by adherent neutrophils occurred efficiently in the absence of opsonins. An antibody specific for S. aureus promoted uptake of unopsonized bacteria in suspension, but had little or no capacity to enhance phagocytosis of S. aureus opsonized with normal human serum or by adherent neutrophils. Collectively, these results indicate that assay conditions can have a significant influence on the phagocytosis and killing of S. aureus by neutrophils. More importantly, the results suggest a vaccine approach directed to enhance opsonophagocytosis alone is not sufficient to promote increased killing of S. aureus by human neutrophils. With the emergence and reemergence of antibiotic-resistant microorganisms, establishing parameters that are optimal for studying neutrophil-S. aureus interactions will pave the way towards developing immune-directed strategies for anti-staphylococcal therapies.

  16. Remarks on the UA4/2 d$\\sigma$/dt and on the asymptotic $\\sigma_{T}$(s) behavior

    CERN Document Server

    Kang, K; Kang, Kyungsik; Valin, Pierre

    1995-01-01

    We find that the UA4/2 measurements on the real part of the forward p \\bar p scattering amplitude and total cross section are consistent with each other and also with the standard picture of the Pomeron of either {\\it ln} ^2 s or {\\it ln} s type. However the asymptotic \\sigma _T (s) behavior obtained from the {\\it ad hoc} parametrization fit to the p \\bar p total cross sections as quoted in the Review of Particle Properties is consistent with the analysis of the class of the analytic amplitude models that contain the {\\it ln} ^2 s type Pomeron term.

  17. Improving Quality of Seal Leak Test Product using Six Sigma

    Science.gov (United States)

    Luthfi Malik, Abdullah; Akbar, Muhammad; Irianto, Dradjad

    2016-02-01

    Seal leak test part is a polyurethane material-based product. Based on past data, defect level of this product was 8%, higher than the target of 5%. Quality improvement effort was done using six sigma method that included phases of define, measure, analyse, improve, and control. In the design phase, a Delphi method was used to identify factors that were critical to quality. In the measure phase, stability and process capability was measured. Fault tree analysis (FTA) and failure mode and effect analysis (FMEA) were used in the next phase to analize the root cause and to determine the priority issues. Improve phase was done by compiling, selecting, and designing alternative repair. Some improvement efforts were identified, i.e. (i) making a checklist for maintenance schedules, (ii) making written reminder form, (iii) modifying the SOP more detail, and (iv) performing a major service to the vacuum machine. To ensure the continuity of improvement efforts, some control activities were executed, i.e. (i) controlling, monitoring, documenting, and setting target frequently, (ii) implementing reward and punishment system, (iii) adding cleaning tool, and (iv) building six sigma organizational structure.

  18. Six Sigma methods applied to cryogenic coolers assembly line

    Science.gov (United States)

    Ventre, Jean-Marc; Germain-Lacour, Michel; Martin, Jean-Yves; Cauquil, Jean-Marc; Benschop, Tonny; Griot, René

    2009-05-01

    Six Sigma method have been applied to manufacturing process of a rotary Stirling cooler: RM2. Name of the project is NoVa as main goal of the Six Sigma approach is to reduce variability (No Variability). Project has been based on the DMAIC guideline following five stages: Define, Measure, Analyse, Improve, Control. Objective has been set on the rate of coolers succeeding performance at first attempt with a goal value of 95%. A team has been gathered involving people and skills acting on the RM2 manufacturing line. Measurement System Analysis (MSA) has been applied to test bench and results after R&R gage show that measurement is one of the root cause for variability in RM2 process. Two more root causes have been identified by the team after process mapping analysis: regenerator filling factor and cleaning procedure. Causes for measurement variability have been identified and eradicated as shown by new results from R&R gage. Experimental results show that regenerator filling factor impacts process variability and affects yield. Improved process haven been set after new calibration process for test bench, new filling procedure for regenerator and an additional cleaning stage have been implemented. The objective for 95% coolers succeeding performance test at first attempt has been reached and kept for a significant period. RM2 manufacturing process is now managed according to Statistical Process Control based on control charts. Improvement in process capability have enabled introduction of sample testing procedure before delivery.

  19. Binding of kappa- and sigma-opiates in rat brain

    Energy Technology Data Exchange (ETDEWEB)

    Wolozin, B.L.; Nishimura, S.; Pasternak, G.W.

    1982-06-01

    Detailed displacements of (/sup 3/H)dihydromorphine by ketocyclazocine and SKF 10,047, (/sup 3/H)ethylketocyclazocine by SKF 10,047, and (/sup 3/H)SKF 10,047 by ketocyclazocine are all multiphasic, suggesting multiple binding sites. After treating brain tissue in vitro with naloxazone, all displacements lose the initial inhibition of /sup 3/H-ligand binding by low concentrations of unlabeled drugs. Together with Scatchard analysis of saturation experiments, these studies suggest a common site which binds mu-, kappa, and sigma-opiates and enkephalins equally well and with highest affinity (KD less than 1 nM). The ability of unlabeled drugs to displace the low affinity binding of (/sup 3/H)dihydromorphine (KD . 3 nM), (/sup 3/H)ethylketocyclazocine (KD . 4 nM), (/sup 3/H)SKF 10,047 (KD . 6 nM), and D-Ala2-D-Leu5-(/sup 3/H)enkephalin (KD . 5 nM) remaining after treating tissue with naloxazone demonstrates unique pharmacological profiles for each. These results suggest the existence of distinct binding sites for kappa- and sigma-opiates which differ from those sites which selectively bind morphine (mu) and enkephalin (delta).

  20. The $L - \\sigma$ relation for massive bursts of star formation

    CERN Document Server

    Chávez, Ricardo; Terlevich, Elena; Bresolin, Fabio; Melnick, Jorge; Plionis, Manolis; Basilakos, Spyros

    2014-01-01

    The validity of the emission line luminosity vs. ionised gas velocity dispersion ($L - \\sigma$) correlation for HII galaxies (HIIGx), and its potential as an accurate distance estimator are assessed. For a sample of 128 local ($0.02\\lesssim z\\lesssim 0.2$) compact HIIGx with high equivalent widths of their Balmer emission lines we obtained ionised gas velocity dispersion from high S/N high-dispersion spectroscopy (Subaru-HDS and ESO VLT-UVES) and integrated H$\\beta$ fluxes from low dispersion wide aperture spectrophotometry. We find that the $L - \\sigma$ relation is strong and stable against restrictions in the sample (mostly based on the emission line profiles). The `gaussianity' of the profile is important for reducing the rms uncertainty of the distance indicator, but at the expense of substantially reducing the sample. By fitting other physical parameters into the correlation we are able to significantly decrease the scatter without reducing the sample. The size of the starforming region is an important s...

  1. Semi-doubled Sigma Models for Five-branes

    CERN Document Server

    Kimura, Tetsuji

    2015-01-01

    We study two-dimensional ${\\cal N}=(2,2)$ gauge theory and its dualized system in terms of complex (linear) superfields and their alternatives. Although this technique itself is not new, we can obtain a new model, the so-called "semi-doubled" GLSM. Similar to doubled sigma model, this involves both the original and dual degrees of freedom simultaneously, whilst the latter only contribute to the system via topological interactions. Applying this to the ${\\cal N}=(4,4)$ GLSM for H-monopoles, i.e., smeared NS5-branes, we obtain its T-dualized systems in quite an easy way. As a bonus, we also obtain the semi-doubled GLSM for an exotic $5^3_2$-brane whose background is locally nongeometric. In the low energy limit, we construct the semi-doubled NLSM which also generates the conventional string worldsheet sigma models. In the case of the NLSM for $5^3_2$-brane, however, we find that the Dirac monopole equation does not make sense any more because the physical information is absorbed into the divergent part via the ...

  2. High speed and wide bandwidth delta-sigma ADCs

    CERN Document Server

    Bolatkale, Muhammed; Makinwa, Kofi A A

    2014-01-01

    This book describes techniques for realizing wide bandwidth (125MHz) over-sampled analog-to-digital converters (ADCs) in nanometer-CMOS processes.  The authors offer a clear and complete picture of system level challenges and practical design solutions in high-speed Delta-Sigma modulators.  Readers will be enabled to implement ADCs as continuous-time delta-sigma (CT∆Σ) modulators, offering simple resistive inputs, which do not require the use of power-hungry input buffers, as well as offering inherent anti-aliasing, which simplifies system integration. The authors focus on the design of high speed and wide-bandwidth ΔΣMs that make a step in bandwidth range which was previously only possible with Nyquist converters. More specifically, this book describes the stability, power efficiency, and linearity limits of ΔΣMs, aiming at a GHz sampling frequency.   • Provides overview of trends in Wide Bandwidth and High Dynamic Range analog-to-digital converters (ADCs); • Enables the design of a wide band...

  3. Nonlinear sigma models with compact hyperbolic target spaces

    Science.gov (United States)

    Gubser, Steven; Saleem, Zain H.; Schoenholz, Samuel S.; Stoica, Bogdan; Stokes, James

    2016-06-01

    We explore the phase structure of nonlinear sigma models with target spaces corresponding to compact quotients of hyperbolic space, focusing on the case of a hyperbolic genus-2 Riemann surface. The continuum theory of these models can be approximated by a lattice spin system which we simulate using Monte Carlo methods. The target space possesses interesting geometric and topological properties which are reflected in novel features of the sigma model. In particular, we observe a topological phase transition at a critical temperature, above which vortices proliferate, reminiscent of the Kosterlitz-Thouless phase transition in the O(2) model [1, 2]. Unlike in the O(2) case, there are many different types of vortices, suggesting a possible analogy to the Hagedorn treatment of statistical mechanics of a proliferating number of hadron species. Below the critical temperature the spins cluster around six special points in the target space known as Weierstrass points. The diversity of compact hyperbolic manifolds suggests that our model is only the simplest example of a broad class of statistical mechanical models whose main features can be understood essentially in geometric terms.

  4. Chaotic Inflation from Nonlinear Sigma Models in Supergravity

    CERN Document Server

    Hellerman, Simeon; Yanagida, Tsutomu T

    2014-01-01

    We present a common solution to the puzzles of the light Higgs or quark masses and the need for a shift symmetry and large field values in high scale chaotic inflation. One way to protect, for example, the Higgs from a large supersymmetric mass term is if it is the Nambu-Goldstone boson (NGB) of a nonlinear sigma model. However, it is well known that nonlinear sigma models (NLSMs) with nontrivial K\\"ahler transformations are problematic to couple to supergravity. An additional field is necessary to make the K\\"ahler potential of the NLSM invariant in supergravity. This field must have a shift symmetry --- making it a candidate for the inflaton (or axion). We give an explicit example of such a model for the coset space $SU(3)/SU(2) \\times U(1)$, with the Higgs as the NGB, including breaking the inflaton's shift symmetry and producing a chaotic inflation potential. This construction can also be applied to other models, such as one based on $E_7/SO(10) \\times U(1) \\times U(1)$ which incorporates the first two ge...

  5. A new putative sigma factor of Myxococcus xanthus.

    Science.gov (United States)

    Apelian, D; Inouye, S

    1993-06-01

    A third putative sigma factor gene, sigC, has been isolated from Myxococcus xanthus by using the sigA gene (formerly rpoD of M. xanthus) as a probe. The nucleotide sequence of sigC has been determined, and an open reading frame of 295 residues (M(r) = 33,430) has been identified. The deduced amino acid sequence of sigC exhibits the features which are characteristic of other bacterial sigma factors. The characterization of a sigC-lacZ strain has demonstrated that sigC expression is induced immediately after cells enter into the developmental cycle and is dramatically reduced at the onset of sporulation. A deletion mutant of sigC grows normally in vegetative culture and is able to develop normally. However, in contrast to the wild-type cells, the sigC deletion mutant cells became capable of forming fruiting bodies and myxospores on semirich agar plates. This suggests that sigC may play a role in expression of genes involved in negatively regulating the initiation of fruiting body formation.

  6. [Investigation on spectrum of B 2sigma(+)-X 2sigma+ and C 2pi(r)-X 2sigma+ bands of AlO radical in shock tube].

    Science.gov (United States)

    Peng, Zhi-Min; Yang, Qian-Suo; Liu, Chun; Zhu, Nai-Yi; Jiang, Zong-Lin

    2010-04-01

    There are some impurities such as aluminum dioxide adhering on the shock tube wall due to the ablating and heating of the aluminum diaphragm by high temperature gas. Under high temperature, the collision of AlO radicals with the gaseous molecules leads to transition of the electronic states and production of strong radiation, which disturb the analysis of radiation spectrum of heated gases in shock tube. In the authors' experiments, the air in the test section with adhering aluminum dioxide was heated to some 4 000-7 000 K, the spectrum of AlO radical was obvious in the range of 460-530 nm, which corresponds to B 2sigma(+)-X 2sigma+ (T00 = 20 689 cm(-1) band. There were several band heads for this band, the interval of neighbor heads was some 2 nm, and all the band heads were with the shortest wavelength. The characteristics of B 2sigma(+)-X 2sigma+ band were explored in experiment and by theory. In addition, the spectrum of C 2pi(r)-X 2sigma+ (T00 = 33 047 cm(-1)) band was also investigated. The corresponding strength was lower than that of B 2sigma(+) -X 2sigma+ band, and the wavelength range of this band was some 270-335 nm where the radiation of A 2sigma(+) -X 2pi (T00 = 32 682 cm(-1)) band of OH radical also existed. This occurrence of the two bands in the same wavelength range is disadvantageous for the spectrum analysis.

  7. THE QUALITY IMPROVEMENT OF PRIMER PACKAGING PROCESS USING SIX SIGMA METHODOLOGY

    Directory of Open Access Journals (Sweden)

    Prima Ditahardiyani

    2008-01-01

    Full Text Available The implementation of Six Sigma has become a common theme in many organizations. This paper presents the Six Sigma methodology and its implementation in a primer packaging process of Cranberry drink. DMAIC (Define, Measure, Analyze, Improve and Control approach is used to analyze and to improve the primer packaging process, which have high variability and defects output. After the improvement, the results showed that there was an increasing sigma level. However, it is not significantly and has not achieved the world standard quality, yet. Therefore, the implementation of Six Sigma in primer packaging process of Cranberry drink still has a room for doing a further research.

  8. Quality assurance and management in microelectronics companies: ISO 9000 versus Six Sigma

    Science.gov (United States)

    Lupan, Razvan; Kobi, Abdessamad; Robledo, Christian; Bacivarov, Ioan; Bacivarov, Angelica

    2009-01-01

    A strategy for the implementation of the Six Sigma method as an improvement solution for the ISO 9000:2000 Quality Standard is proposed. Our approach is focused on integrating the DMAIC cycle of the Six Sigma method with the PDCA process approach, highly recommended by the standard ISO 9000:2000. The Six Sigma steps applied to each part of the PDCA cycle are presented in detail, giving some tools and training examples. Based on this analysis the authors conclude that applying Six Sigma philosophy to the Quality Standard implementation process is the best way to achieve the optimal results in quality progress and therefore in customers satisfaction.

  9. An investigation on dysphotopsia of a sigma-edged intraocular lens

    Institute of Scientific and Technical Information of China (English)

    Zhishan Gao; Meimei Kong; Xinhua Li; Lei Chen; Rihong Zhu

    2006-01-01

    @@ A sigma-edged design of intraocular lens (IOL) is proposed to minimize the reflected glare images associated with the edge. The optimal sigma inverse edge is investigated when pupil diameter is 5.0 mm by the established Escudero-Sanz's wide angle model. The non-sequential ray tracing program of Zemax-EE (Zemax Development Corp., San Diego, USA) is used to investigate the sigma edge of reducing the potential for edge glare phenomena. The results show that sigma-edged design can significantly reduce the reflected glare intensity on retina if the angle of its inverse edge is taken from 20 to 70 degrees.

  10. Determination of the pi Sigma scattering lengths from the weak decays of Lambda_c

    CERN Document Server

    Hyodo, Tetsuo

    2011-01-01

    The scattering lengths of the pi Sigma systems are key quantities in understanding the structure of the Lambda(1405) resonance and the subthreshold extrapolation of the barK N interaction. We demonstrate that the pi Sigma scattering lengths can be extracted from the threshold cusp phenomena in the weak Lambda_c -> pi pi Sigma decays, in analogy with Cabibbo's method for determination of the pi pi scattering length. We show that the substantial cusp effect should be observed in the spectrum, when the pi Sigma interaction in I=0 is strongly attractive so as to generate near threshold singularity, such as a bound state or a virtual state.

  11. Six Sigma Quality Management System and Design of Risk-based Statistical Quality Control.

    Science.gov (United States)

    Westgard, James O; Westgard, Sten A

    2017-03-01

    Six sigma concepts provide a quality management system (QMS) with many useful tools for managing quality in medical laboratories. This Six Sigma QMS is driven by the quality required for the intended use of a test. The most useful form for this quality requirement is the allowable total error. Calculation of a sigma-metric provides the best predictor of risk for an analytical examination process, as well as a design parameter for selecting the statistical quality control (SQC) procedure necessary to detect medically important errors. Simple point estimates of sigma at medical decision concentrations are sufficient for laboratory applications.

  12. THE IMPLEMENTATION OF SIX SIGMA IN MANUFACTURING ORGANIZATIONS: MOTIVATIONS AND RESULTS ACHIEVED

    Directory of Open Access Journals (Sweden)

    Antônio Domingos Padula

    2005-12-01

    Full Text Available The competitive context forces organizations to choose improvement tools that yield maximum efficiency from their operations. There are many articles about Six Sigma in the technical literature but academic research is not so abundant. This research aims at evaluating how Six Sigma implementation takes place and identifies critical success factors, by analyzing six industrial organizations which have already adopted Six Sigma. The results show convergence between organizations and aspects that maximize gains beyond those publicized on Six Sigma methodology. The research concludes that adherence to the methodology, support from Upper Management and alignment with other initiatives are critical success factors.

  13. Six sigma in production engine development - the new GE evolution series diesel engine; Six Sigma in der Motorenentwicklung - der neue GE Evolution Series Diesel Motor

    Energy Technology Data Exchange (ETDEWEB)

    Flynn, P.L.; Donner, J.L. [GE Rail, Erie, PA (United States); Hupperich, P.; Reichert, E. [FEV Engine Technology, Auburn Hills, MI (United States)]|[FEV Motorentechnik, Aachen (Germany)

    2004-07-01

    Triggered by stories of success from high-profile corporations, such as Motorola (1987), Texas Instruments (1988) and Allied Signal (1993), the Six Sigma business approach has gained worldwide recognition as a Total Quality Management tool. It has allowed organizations to dramatically improve the quality and consistency of their products and processes, reduce cost and, ultimately, increase customer satisfaction. The launch of the six sigma effort at general electric in 1995 and the associated corporate focus on quality has set the stage for the first ever full-scale application of six sigma in a concept-to-production engine development program. (orig.)

  14. THE APPROXIMATION PROBLEMS ON SIGMA-PI NEURAL NETWORKS%关于Sigma-Pi神经网络中的逼近问题

    Institute of Scientific and Technical Information of China (English)

    罗跃虎; 沈世镒

    2000-01-01

    研究R上不连续函数可作为Sigma-Pi神经网络激励函数的条件.给出了R上局部黎曼可积函数可作为Sigma-Pi神经网络激励函数的特征条件.本文的结果表明:局部黎曼可积函数作为Sigma-Pi神经网络激励函数的特征条件与连续函数时的情形是一致的.

  15. Ab initio studies of low-lying 3Sigma(-), 3Pi, and 5Sigma(-) states of NH. I - Potential curves and dipole moment functions

    Science.gov (United States)

    Goldfield, Evelyn M.; Kirby, Kate P.

    1987-01-01

    Configuration interaction wave functions, potential energy curves, and dipole moment functions have been calculated for the four lowest 3Sigma(-) and the three lowest 3Pi states and 5Sigma(-) states of NH. The electronic wave functions were constructed to give a balanced description of valence-Rydberg interactions. Two repulsive states have been identified as important photodissociation pathways. Spectroscopic constants are presented for the bound states, and results are compared to other theoretical and experimental work. The possible predissociation of the A 3Pi state by the 1 5Sigma(-) state is discussed.

  16. The virulence regulator Sae of Staphylococcus aureus: promoter activities and response to phagocytosis-related signals.

    Science.gov (United States)

    Geiger, Tobias; Goerke, Christiane; Mainiero, Markus; Kraus, Dirk; Wolz, Christiane

    2008-05-01

    The two-component system SaeRS of Staphylococcus aureus is closely involved in the regulation of major virulence factors. However, little is known about the signals leading to saeRS activation. A total of four overlapping transcripts (T1 to T4) from three different transcription starting points are expressed in the sae operon. We used a beta-galactosidase reporter assay to characterize the putative promoter regions within the saeRS upstream region. The main transcript T2 is probably generated by endoribonucleolytic processing of the T1 transcript. Only two distinct promoter elements (P1 and P3) could be detected within the saeRS upstream region. The P3 promoter, upstream of saeRS, generates the T3 transcript, includes a cis-acting enhancer element and is repressed by saeRS. The most distal P1 promoter is strongly autoregulated, activated by agr, and repressed by sigma factor B. In strain Newman a mutation within the histidine kinase SaeS leads to a constitutively activated sae system. Evaluation of different external signals revealed that the P1 promoter in strain ISP479R and strain UAMS-1 is inhibited by low pH and high NaCl concentrations but activated by hydrogen peroxide. The most prominent induction of P1 was observed at subinhibitory concentrations of alpha-defensins in various S. aureus strains, with the exception of strain ISP479R and strain COL. P1 was not activated by the antimicrobial peptides LL37 and daptomycin. In summary, the results indicate that the sensor molecule SaeS is activated by alteration within the membrane allowing the pathogen to react to phagocytosis related effector molecules.

  17. Induction of virulence gene expression in Staphylococcus aureus by pulmonary surfactant.

    Science.gov (United States)

    Ishii, Kenichi; Adachi, Tatsuo; Yasukawa, Jyunichiro; Suzuki, Yutaka; Hamamoto, Hiroshi; Sekimizu, Kazuhisa

    2014-04-01

    We performed a genomewide analysis using a next-generation sequencer to investigate the effect of pulmonary surfactant on gene expression in Staphylococcus aureus, a clinically important opportunistic pathogen. RNA sequence (RNA-seq) analysis of bacterial transcripts at late log phase revealed 142 genes that were upregulated >2-fold following the addition of pulmonary surfactant to the culture medium. Among these genes, we confirmed by quantitative reverse transcription-PCR analysis that mRNA amounts for genes encoding ESAT-6 secretion system C (EssC), an unknown hypothetical protein (NWMN_0246; also called pulmonary surfactant-inducible factor A [PsiA] in this study), and hemolysin gamma subunit B (HlgB) were increased 3- to 10-fold by the surfactant treatment. Among the major constituents of pulmonary surfactant, i.e., phospholipids and palmitate, only palmitate, which is the most abundant fatty acid in the pulmonary surfactant and a known antibacterial substance, stimulated the expression of these three genes. Moreover, these genes were also induced by supplementing the culture with detergents. The induction of gene expression by surfactant or palmitate was not observed in a disruption mutant of the sigB gene, which encodes an alternative sigma factor involved in bacterial stress responses. Furthermore, each disruption mutant of the essC, psiA, and hlgB genes showed attenuation of both survival in the lung and host-killing ability in a murine pneumonia model. These findings suggest that S. aureus resists membrane stress caused by free fatty acids present in the pulmonary surfactant through the regulation of virulence gene expression, which contributes to its pathogenesis within the lungs of the host animal.

  18. Application of sigma metrics for the assessment of quality assurance in clinical biochemistry laboratory in India: a pilot study.

    Science.gov (United States)

    Singh, Bhawna; Goswami, Binita; Gupta, Vinod Kumar; Chawla, Ranjna; Mallika, Venkatesan

    2011-04-01

    Ensuring quality of laboratory services is the need of the hour in the field of health care. Keeping in mind the revolution ushered by six sigma concept in corporate world, health care sector may reap the benefits of the same. Six sigma provides a general methodology to describe performance on sigma scale. We aimed to gauge our laboratory performance by sigma metrics. Internal quality control (QC) data was analyzed retrospectively over a period of 6 months from July 2009 to December 2009. Laboratory mean, standard deviation and coefficient of variation were calculated for all the parameters. Sigma was calculated for both the levels of internal QC. Satisfactory sigma values (>6) were elicited for creatinine, triglycerides, SGOT, CPK-Total and Amylase. Blood urea performed poorly on the sigma scale with sigma six sigma standards for all the analytical processes.

  19. On the A-dependence of {sigma}{sub L}/{sigma}{sub T}: Skeletons in the shadow

    Energy Technology Data Exchange (ETDEWEB)

    Milana, J. [Univ. of Maryland, College Park (United States)

    1994-04-01

    A most counter-intuitive dependence in the differential cross-section in the shadowing regime is shown to result from a higher-twist nuclear enhancement in R = {sigma}{sub L}/{sigma}{sub T} which severely complicates the unravelling from present data the corresponding dependence in Q{sup 2} of the nuclear structure functions, F{sub 2}{sup A}(x,Q{sup 2}). Indeed, until precision measurements close this loophole, the extrapolations of the structure functions to either higher Q{sup 2} or other processes (as is necessary to address present data at FNAL or future experiments at RHIC) must be considered problematic. The contribution CEBAF can make in this regard by providing systematic determination of R{sub A}(x, Q{sup 2}) is thus emphasized. The purpose of this talk is to motivate an experiment CEBAF can and should do, especially if upgraded to higher energies. While providing information on nuclear structure that is interesting in itself, the added motivation is that precision results will have important impact on other high-energy experiments involving nuclear targets that have been, and will continue to be done all over the world.

  20. Staphylococcus aureus: resistance pattern and risk factors

    Directory of Open Access Journals (Sweden)

    Mohammad Naghavi-Behzad

    2015-03-01

    Full Text Available Introduction: Methicillin resistant Staphylococcus aureus (MRSA has emerged as a nosocomial pathogen of major worldwide importance and is an increasingly frequent cause of community-acquired infections. In this study, different risk factors and MRSA resistance pattern were investigated. Methods: In a 24 months period, all of the patients who were confined to bed in the surgery ward were included in the study. Then they were assessed to find out as if they had MRSA infection when hospitalized and once when they were discharged. Almost 48 h after admission, when patients were discharged, social and medical histories were acquired. Acquired samples were examined. Results: During the present study of 475 patients, 108 patients (22.8% had S. aureus. About frequency of antibiotic resistance among collected S. aureus colonies, erythromycin resistance, was the most frequent antibiotic resistance, also resistance to vancomycin was 0.4% that was the least. Only hospitalization duration had statistically significant correlation with antibiotic resistance, also resistance to erythromycin had statistically significant relation with history of surgery and alcohol consumption. Of all 34 MRSA species, 22 (64.7% samples were resistant to erythromycin, 17 (50.0% resistant to cefoxitin, 5 (14.7% resistant to mupirocin, 1 (2.9% resistant to vancomycin and 1 (2.9% resistant to linezolid. Conclusion: The results of the current study show that among hospitalized patients, there is resistance against methicillin. Since based on results of the study there is resistance against oxacillin and erythromycin in most cases, administering appropriate antibiotics have an important role in minimizing the resistance burden among bacterial species.