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Sample records for aura retracting particle-like

  1. Retracted

    Science.gov (United States)

    Zhu, Yongjian; Luan, Zhu; Yang, Qingguo; Li, Dashan; Lu, Wei; Liu, Liren

    2007-04-01

    This article has been retracted at the request of the Editor-in-Chief and Author. Please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). Reason: A significant error in calculation was discovered after repeating the VC programming presented in the paperE In the previous programming, the authors neglected to include a term in the reliability function formula due to a spelling mistake, which will lead to a completely different result.

  2. Retraction.

    Science.gov (United States)

    2016-12-01

    This article corrects: Retracted: Three BUB1 and BUBR1/MAD3-related spindle assembly checkpoint proteins are required for accurate mitosis in Arabidopsis. New Phytologist 205: 202-215. Article first published online: 29 September 2014. This article has been retracted at the request of: Editor-in-Chief and Author 'Three BUB1 and BUBR1/MAD3-related spindle assembly checkpoint proteins are required for accurate mitosis in Arabidopsis', by Paganelli L, Caillaud M-C, Quentin M, Damiani I, Govetto B, Lecomte P, Karpov, PA, Abad P, Chabouté M-E and Favery B. The above article, first published online on Wiley Online Library (wileyonlinelibrary.com), and in New Phytologist 205: 202-215, has been retracted by agreement between the authors, the journal Editor-in-Chief, Alistair Hetherington, and John Wiley & Sons Ltd. Since publication of the above article, it has been brought to our attention that errors occurred in the construction of Figs 1 and 2(a); some components were inappropriately edited and duplicated, including the duplication and editing of images that first appeared in Caillaud et al. (2009), which were used by the authors as a basic template. Consequently, the integrity of the yeast two-hybrid experiments reported in the article is undermined, and, with agreement of all parties, the decision has been made to retract this article. We apologize for any inconvenience the publication of this work may have caused our readers. References Caillaud MC, Paganelli L, Lecomte P, Deslandes L, Quentin M, Pecrix Y, Le Bris M, Marfaing N, Abad P, Favery B. 2009. Spindle assembly checkpoint protein dynamics reveal conserved and unsuspected roles in plant cell division. PLoS One 4: e6757. Paganelli L, Caillaud M-C, Quentin M, Damiani I, Govetto B, Lecomte P, Karpov PA, Abad P, Chabouté M-E, Favery B. 2015. Three BUB1 and BUBR1/MAD3-related spindle assembly checkpoint proteins are required for accurate mitosis in Arabidopsis. New Phytologist 205: 202-215. © 2016 The Authors

  3. Retraction

    Directory of Open Access Journals (Sweden)

    Li JZ

    2016-02-01

    Full Text Available Li J-Z, Zhang Y, Wen B, Li M, Wang Y-J. Ability of PITX2 methylation to predict survival in patients with prostate cancer. OncoTargets Ther. 2015;8:3507–3512.Large sections of text in this paper have been reused, albeit with minimal re-wording, without citation back to the source:Li J-Z, Zhang Y, Wen B, Li M, and Wang Y-J have failed to provide any explanation for the unauthorised re-use of figures and tables from the 2014 publication, Vasiljevic N, Ahmad AS, Carter PD, Fisher G, Berney DM, Foster CS, Cuzick J, Lorincz AT. DNA methylation of PITX2 predicts poor survival in men with prostate cancer. Biomark Med. 2014;8(9:1143–1150. This retraction relates to this paper 

  4. Retraction

    Directory of Open Access Journals (Sweden)

    Gu J

    2016-02-01

    Full Text Available Gu J, Sun R, Shen S, Yu Z. The influence of TLR4 agonist lipopolysaccharides on hepatocellular carcinoma cells and the feasibility of its application in treating liver cancer. Onco Targets Ther. 2015;8:2215–2225.The first author (Junsheng Gu created an email address for Dr Yu without permission and used figures from a previously published paper: Lin A, Wang G, Zhao H, et al. TLR4 signaling promotes a COX-2/PGE2/STAT3 positive feedback loop in hepatocellular carcinoma (HCC cells. OncoImmunology. 2015: DOI:10.1080/2162402X.This was done without the knowledge, involvement, or permission of Dr Yu. This retraction relates to this paper

  5. Migraine aura

    DEFF Research Database (Denmark)

    Charles, Andrew; Hansen, Jakob Møller

    2015-01-01

    PURPOSE OF REVIEW: The migraine aura is a dramatic spontaneous change in brain activity resulting in a variety of transient neurological symptoms. The purpose of this review is to address recent advances in the understanding of aura and its role in migraine. RECENT FINDINGS: The formal...... classification of migraine aura is becoming both broader and more detailed. Traditionally viewed as a primary event that triggers a migraine attack, studies regarding the timing of aura relative to other symptoms of migraine indicate that it may not in fact play a primary role in initiating an attack. Careful...... recording and analysis of visual aura symptoms provides new insight into the initiation and propagation of the underlying brain phenomenon, and the different regions of visual cortex that produce different visual perceptions. Migraine with aura may have different responses to acute and preventive therapies...

  6. RETRACTION NOTE

    Directory of Open Access Journals (Sweden)

    Biryukova NA.

    2017-03-01

    Full Text Available Retracted article: Biryukova NA. Otsenka lichnostnogo razvitiya vzroslogo kak indikator kachestva dopolnitelnogo obrazovaniya [Assessment of the adult’s personal development as an indicator of the quality of further education]. Integratsiya obrazovaniya = Integration of Education. 2016; 2(20:238-244. DOI: 10.15507/1991-9468.083.020.201602.238-244 (In Russian This article by Natalia A. Biryukova (Email: pedagog-108@marsu.ru has been retracted (i.e. withdrawn from the press by the editor with permission of the publisher. The reason for the article retraction is redundant publication: the author has published substantially the same article under the same title in the journal “Obrazovanie i nauka [Education and Science]” (2016; 6(135:141-151. The Editorial Board would like to extend its sincere apologies for any inconvenience this retraction may have caused.

  7. Migraine with Aura

    Science.gov (United States)

    Migraine with aura Overview Migraine with aura (also called classic migraine) is a headache that strikes after or along with sensory disturbances called aura. These disturbances can include flashes ...

  8. RETRACTED: Hydrological

    Directory of Open Access Journals (Sweden)

    S.S. Panhalkar

    2014-12-01

    This paper has been retracted upon the request of the author and the editor as the paper requires major revision. The author did not have the permission to publish part of the discharge information presented in Figures 10–13. The Publisher apologizes for any inconvenience this may cause.

  9. Retraction notice.

    Science.gov (United States)

    2017-02-01

    At the request of the Journal Editor and the Publisher, the following article has been retracted: Khani Jeihooni A, Hidarnia A, Hossein Kaveh M, Hajizadeh E and Askari A (2015) The effect of an education program based on health belief model and social cognitive theory in prevention of osteoporosis in women. Journal of Health Psychology. Epub ahead of print 8 September. DOI: 10.1177/1359105315603696.

  10. Airbag retraction

    Science.gov (United States)

    1997-01-01

    This image shows that the Mars Pathfinder airbags have been successfully retracted, allowing safe deployment of the rover ramps. The Sojourner rover, still in its deployed position, is at center image, and rocks are visible in the background. Mars Pathfinder landed successfully on the surface of Mars today at 10:07 a.m. PDT.Mars Pathfinder is the second in NASA's Discovery program of low-cost spacecraft with highly focused science goals. The Jet Propulsion Laboratory, Pasadena, CA, developed and manages the Mars Pathfinder mission for NASA's Office of Space Science, Washington, D.C. JPL is an operating division of the California Institute of Technology (Caltech). The Imager for Mars Pathfinder (IMP) was developed by the University of Arizona Lunar and Planetary Laboratory under contract to JPL. Peter Smith is the Principal Investigator.

  11. The Aura Mission

    Science.gov (United States)

    Schoeberl, Mark R.

    2008-01-01

    Aura was designed to probe the chemistry of the troposphere as well as the stratosphere. Two instruments, the Microwave Limb Sounder, the Tropospheric Emission Spectrometer (TES) and the Ozone Monitoring Instrument (OMI) have provided some remarkable information on pollution, long range pollution transport and strat-trop exchange. This talk will review some of the more startling observations and some new science that we are seeing in the Aura data.

  12. Aura of mystery.

    Science.gov (United States)

    Dolgin, Elie

    2013-09-01

    It begins as a slowly expanding spot of light or similar visual disturbance, often accompanied by phantom noises and other sensory distortions. People who experience such 'auras' know all too well that these early warning signs will culminate in a head-splitting migraine, yet scientists have little idea what causes the debilitating deluge of symptoms. Elie Dolgin talks to neurologists hoping to change that - by triggering auras in the laboratory in order to study them.

  13. Discoveries from EOS Aura

    Science.gov (United States)

    Douglass, Anne

    2006-01-01

    Aura, the third and final of three large observatories that are part of NASA s Earth Observing System, was launched July 15,2004. Aura carries four instruments - the Microwave Limb Sounder (MLS), the Tropospheric Emission Spectrometer (TES), the Ozone Monitoring Instrument (OMI) and the High Resolution Dynamics Limb Sounder (HIRDLS), all of which measure atmospheric constituents. Aura measurements provide information to address broad questions about the Earth atmosphere, particularly concerning the recovery of the stratospheric ozone layer, tropospheric air quality, and climate change. TES has made the simultaneous measurements of carbon monoxide and ozone in the lower and upper troposphere. OM1 continues to observe the total ozone column and measures columns of important pollutants like NO2 at unprecedented horizontal resolution and coverage. MLS measures profiles of stratospheric ozone and constituents that affect ozone from the mesosphere into the upper troposphere. This talk will highlight results from Aura s first years in orbit, and will emphasize the way information from Aura and other satellites has contributed to the development, evaluation, and application of global chemistry climate models.

  14. EOS Aura Mission Status

    Science.gov (United States)

    Guit, William J.

    2015-01-01

    This PowerPoint presentation will discuss EOS Aura mission and spacecraft subsystem summary, recent and planned activities, inclination adjust maneuvers, propellant usage lifetime estimate. Eric Moyer, ESMO Deputy Project Manager-Technical (code 428) has reviewed and approved the slides on April 30, 2015.

  15. [Migraine with visual aura].

    Science.gov (United States)

    Bidot, S; Biotti, D

    2016-06-01

    Migraine with visual aura is marked by recurrent episodes of transient visual disturbance, often followed by headaches. Its pathophysiology has not been fully understood, but visual auras might be related to a self-propagating wave of cortical depolarization called "cortical spreading depression", triggering a trigemino-vascular "storm" ultimately leading to headaches. The most specific visual symptom is the "fortification spectrum" consisting of glimmering jagged lines spreading from the center to the periphery, and leaving a transient scotoma in its wake. Other visual symptoms are numerous, ranging from elementary positive or negative visual phenomena to complex and elaborate hallucinations. The diagnosis can be made according to the International Classification of Headache Disorders revised in 2013. The main goal of the treatment is to relieve the patient's pain quickly and to decrease the frequency of the episodes. Copyright © 2016 Elsevier Masson SAS. All rights reserved.

  16. Las declinaciones del aura

    Directory of Open Access Journals (Sweden)

    Cecilia Bettoni

    2016-11-01

    Full Text Available Habitualmente, asociamos el concepto benjaminiano de aura a una cualidad de la obra de arte que desfallece con el creciente desarrollo de las técnicas mecánicas de reproducción. Sin embargo, el mismo Benjamin señala que este desfallecimiento es un proceso sintomático, cuyo significado desborda el dominio puramente artístico. En este contexto, el presente artículo indaga este desborde a partir de la elasticidad que la noción de aura alcanza en la obra de Walter Benjamin, con el objeto de demostrar que este concepto no constituye un elemento privativo de las obras de arte, sino que se refiere más bien a cierta modulación de la experiencia histórica y estética

  17. Preputial retraction in children

    Directory of Open Access Journals (Sweden)

    Agarwal Abhinav

    2005-01-01

    Full Text Available OBJECTIVE: The aim of the study was to assess preputial retractability in children at various ages. MATERIALS AND METHODS: Nine hundred and sixty boys attending the hospital were included in the study. Children with hypospadias or history of preputial manipulation were excluded. Preputial anatomy was studied and subjects were classified into five groups as described by Kayaba et al . RESULTS: The prepuce could not be retracted at all so as to make even the external urethral meatus visible in 61.4% children aged 0-6 months while this decreased to only 0.9% in children aged 10-12 years. At the other end of the spectrum, while prepuce could not be fully retracted in any child below 6 months, it could be done in about 60% in the age group of 10-12 years. CONCLUSION Preputial nonseparation is the major cause of preputial nonretraction in the pediatric age group. Prepuce spontaneously separates from the glans as age increases and true phimosis is rare in children. Surgical intervention should be avoided for nonseparation of prepuce.

  18. The Tie retraction syndrome.

    Science.gov (United States)

    Geerling, Gerd; Neppert, Birte; Hemmant, Bridget

    2012-12-01

    Tissue retraction is implicated in the pathogenesis of various ophthalmic disorders. Here we describe the clinical characteristics, epidemiology and pathophysiology of a form of retraction syndrome which - to the best of our knowledge - has not been reported in the ophthalmic literature so far. We have termed this condition - consisting of a slowly progressive pseudovertical shortening of tie length due to a horizontal extension of girth length - the "Tie retraction syndrome" (TRS). Other pathognomonic features include an increased tie tip to belt buckle distance and a prolapse of the subumbilical fat pad (SUFP). The syndrome has a clear male to female preponderance and shows an increasing incidence with age and income before tax. Based on a newly proposed grading scheme we discuss and illustrate the diagnosis as well as the medical and surgical management options of this abundant, but often undiagnosed condition. The authors have no explanation for the apparent lack of awareness for this widely preponderant syndrome and its severe cosmetically disfiguring potential. We thus would like to invite all fellow colleagues with expertise in the field to comment or present their views.

  19. Clinical Analysis of Partial Epilepsy with Auras.

    Science.gov (United States)

    Liu, Yang; Guo, Xiao-Ming; Wu, Xun; Li, Ping; Wang, Wei-Wei

    2017-02-05

    An aura is usually considered to be the initial clinical sign of a seizure. The types of abnormal neuron activities (i.e., localized and generalized firing) play an important role in the diagnosis of epilepsy. The goal of this study was to investigate the types of auras and its correlation with the localization and treatment of epilepsy. The 426 epileptic patients with auras from a single center were reviewed with reference to International League Against Epilepsy (ILAE, 1981) classification; the clinical manifestations and incidence of auras were analyzed in this retrospective study, as well as the results of electroencephalogram (EEG), brain magnetic resonance imaging (MRI) and the treatment methods. Among the 426 epileptic patients, six different types of auras were defined, including autonomic auras, sensory auras, mental and affective auras, aura as vertigo, cognitive auras, and unspeakable feelings. Duration of auras ranged from 2 s to 7 min; the median duration of auras was 64.2 s. Abnormal EEG was observed in 297 (69.72%) patients. Moreover, abnormal brain MRI was observed in 125 (29.34%) patients. Nineteen (4.46%) epilepsy patients with auras underwent both surgeries and antiepileptic drugs (AEDs) while others were treated only with AEDs. This study suggested that auras played an important role in the diagnosis, classification, and localization of epilepsy. Epileptic aura could help differentiate partial seizure from generalized seizure.

  20. NASA 3D Models: Aura

    Data.gov (United States)

    National Aeronautics and Space Administration — Aura observes the chemical content of the atmosphere to track the state of the ozone layer and the dispersion of airborne pollution. Polygons: 6 Vertices: 4

  1. Corrigendum / Erratum / Retraction

    Directory of Open Access Journals (Sweden)

    Istadi Istadi

    2017-05-01

    Full Text Available RETRACTION TO: Dhal, G.C., Dey, S., Prasad, R., Mohan, D. (2017. Simultaneous Elimination of Soot and NOX through Silver-Barium Based Catalytic Materials. Bulletin of Chemical Reaction Engineering & Catalysis, 12 (1: 71-80 (doi:10.9767/bcrec.12.1.647.71-80 This article has been retracted by Publisher based on the following reason: Letter to Editor from Prof. James J. Spivey (Department of Chemical Engineering, Louisiana State University who reported that a comparison of this paper with a previously paper published in Catalysis Today (258 (2015 405-415, doi:10.1016/j.cattod.2015.02.024 shows significant duplication according to analysis by iThenticate shows 73% similarity, which is far more than acceptable. The authors have plagiarized part of the paper that had already published in [Catalysis Today (258 (2015 405-415, doi:10.1016/j.cattod.2015.02.024]. Based on clarification via email, Authors of the above paper have admitted their plagiarism to the previously published paper by Catalysis Today. Editor of Bulletin of Chemical Reaction Engineering & Catalysis acknowledged Prof. James J. Spivey due to the valuable Letter to Editor. One of the conditions of submission of a paper for publication in this journal is that authors declare explicitly that their work is original and has not appeared in a publication elsewhere. Re-use of any data should be appropriately cited. As such this article represents a severe abuse of the scientific publishing system. The scientific community takes a very strong view on this matter and apologies are offered to readers of the journal that this was not detected during the submission process.

  2. Notice of retraction

    Directory of Open Access Journals (Sweden)

    Tunali S

    2010-08-01

    Full Text Available Dear Colleagues,It has recently been brought to my attention that the following case report by Padeyappanavar et al., which was published online in the International Journal of Anatomical Variations (IJAV on February 23rd, 2010 (Padeyappanavar KV, Kazi AK, Nagaleekar A, Kulkarni D, Kulkarni U, Hukkeri V. Elongated styloid process – report of three cases. International Journal of Anatomical Variations. 2010; 3: 30–32. [1], has already been published in the Journal of the Anatomical Society of India in June 2008 [2], and in the Al Ameen Journal of Medical Sciences in January 2010 [3]. The manuscript has been submitted to IJAV in July 30th, 2009, and accepted for publication in January 22nd, 2010. It is obvious that the manuscript has been submitted to IJAV one year later to its initial publication in the Journal of the Anatomical Society of India. The editorial office of IJAV has confirmed that this case report by Padeyappanavar et al. was a duplicate publication, violating the publication agreement of IJAV. The most important condition of submission of a manuscript for publication is explicit declaration of the authors that the paper has not been published or is not under consideration for publication in any other journal. As such this manuscript represents a severe abuse of the scientific publishing system.We immediately contacted the corresponding author (Dr. Kiran V. Padeyappanavar, Department of Anatomy, Belgaum Institute of Medical Sciences, India. E-mail: dr.kiranvp@gmail.com. Unfortunately, we could not get a satisfactory or logical explanation. Therefore, we hereby notice our readers that the paper by Padeyappanavar et al. [1] has been retracted.The institutions of the authors will also be advised via this notice of retraction.We deeply apologize to our readers and the international scientific community for this inconvenience that was totally occurred out of IJAV, and respectfully announce to the scientific world

  3. Cephalic aura after frontal lobe resection.

    Science.gov (United States)

    Kakisaka, Yosuke; Jehi, Lara; Alkawadri, Rafeed; Wang, Zhong I; Enatsu, Rei; Mosher, John C; Dubarry, Anne-Sophie; Alexopoulos, Andreas V; Burgess, Richard C

    2014-08-01

    A cephalic aura is a common sensory aura typically seen in frontal lobe epilepsy. The generation mechanism of cephalic aura is not fully understood. It is hypothesized that to generate a cephalic aura extensive cortical areas need to be excited. We report a patient who started to have cephalic aura after right frontal lobe resection. Magnetoencephalography (MEG) showed interictal spike and ictal change during cephalic aura, both of which were distributed in the right frontal region, and the latter involved much more widespread areas than the former on MEG sensors. The peculiar seizure onset pattern may indicate that surgical modification of the epileptic network was related to the appearance of cephalic aura. We hypothesize that generation of cephalic aura may be associated with more extensive cortical involvement of epileptic activity than that of interictal activity, in at least a subset of cases. Copyright © 2014 Elsevier Ltd. All rights reserved.

  4. Improved description of the migraine aura by a diagnostic aura diary

    DEFF Research Database (Denmark)

    Russell, M B; Iversen, Helle Klingenberg; Olesen, J

    1994-01-01

    We present a diagnostic aura diary for prospective recordings of migraine with aura. Three questionnaires are supplemented with sheets for drawings and plottings of visual and sensory auras. Twenty patients recorded 54 attacks of migraine with aura and 2 attacks of migraine aura without headache....... The visual and sensory aura were usually gradually progressive, reaching maximum development in 15 and 25 min (median) respectively and had a total duration of 20 and 55 min (median) respectively. Approximately 13% of the attacks had acute onset of visual aura associated with other features more typical...... of migraine. The visual and sensory auras always preceded typical migraine headache, and headache occurring before aura symptoms was always of the tension type. The migraine headache was milder than in attacks of migraine without aura and often did not have migraine characteristics. In attacks with unilateral...

  5. Mission Status at Aura Science Team MOWG Meeting: EOS Aura

    Science.gov (United States)

    Fisher, Dominic

    2016-01-01

    Presentation at the 24797-16 Earth Observing System (EOS) Aura Science Team Meeting (Mission Operations Work Group (MOWG)) at Rotterdam, Netherlands August 29, 2016. Presentation topics include mission summary, spacecraft subsystems summary, recent and planned activities, spacecraft anomalies, data capture, propellant usage and lifetime estimates, spacecraft maneuvers and ground track history, mission highlights and past spacecraft anomalies and reliability estimates.

  6. Migraine: Does aura require investigation?

    Science.gov (United States)

    Vijiaratnam, Nirosen; Barber, Daniel; Lim, Kai Zheong; Paul, Eldho; Jiang, Matthew; Chosich, Benjamin; Wijeratne, Tissa

    2016-09-01

    Migraine is a debilitating condition that affects approximately 15% of the general population. It represents a huge proportion of presentations to the emergency department and a significant number of neurology admissions. Patients are often investigated with imaging. This is particularly the case with migraine with aura (MA). The yield of imaging is however low. There is limited information on Australian hospital presentations and utility of imaging. We aimed to analyse the demographics of migraine presentations to our hospital and the yield of imaging in our centre to help guide future approaches to these patients. We retrospectively looked at medical records of patients presenting to the western health from January 2012 to June 2013. Patients were classified as either having migraine with aura or without. Baseline demographics, cardiovascular risk factors and imaging studies (CT brain, MRI brain and carotid Doppler studies) in each group were evaluated. Patients found to have white matter hyperintensities on MRI were further evaluated. We found patients with aura were more likely to have hypercholesterolemia (12% vs 7%, p=0.05). Patients with aura were more likely to be evaluated with imaging (CT brain (70% vs 41% paura were investigated with carotid Doppler studies. Only 1 patient had an abnormal result. Patients with white matter hyperintensities were older (51 vs 39 years; paura to be largely similar. We also found imaging in either group to be of almost no clinical value. Copyright © 2016 Elsevier B.V. All rights reserved.

  7. Reduced efficacy of sumatriptan in migraine with aura vs without aura

    DEFF Research Database (Denmark)

    Hansen, Jakob Møller; Goadsby, Peter J; Charles, Andrew

    2015-01-01

    OBJECTIVE: To determine whether acute migraine treatment outcome is different in migraine with aura compared with migraine without aura. METHODS: We examined pooled outcome data for sumatriptan treatment of migraine with and without aura from the sumatriptan/naratriptan aggregate patient database....... We also examined similar outcome data for inhaled dihydroergotamine (DHE) from a single, large randomized controlled study. RESULTS: The pooled pain-free rates 2 hours postdose for sumatriptan 100 mg were significantly higher in patients treating attacks without aura (32%) compared with the group who...... treated attacks with aura (24%) (p aura was 1.33 (95% confidence interval: 1.16-1.54). The number needed to treat for 2 hours of pain freedom was 4.4 for attacks without aura and 6.2 for attacks with aura. For the clinical...

  8. Corticotomy-assisted retraction: An outcome assessment

    National Research Council Canada - National Science Library

    Krishnaswamy, NR; Sakthi, SVijayashri; Vikraman, B; Shobana, VR; Iyer, SKavitha

    2014-01-01

      Background: To assess the efficiency and treatment outcome of patients treated with corticotomy-assisted en-masse orthodontic retraction as compared with the en-masse retraction without corticotomy...

  9. JPL Testbed Image of Airbag Retraction

    Science.gov (United States)

    2004-01-01

    This image shows the deflated airbags retracted underneath the lander petal at the JPL In-Situ Instrument Laboratory. Retracting the airbags helps clear the path for the rover to roll off the lander and onto the martian surface.

  10. Retracted publications in the drug literature.

    Science.gov (United States)

    Samp, Jennifer C; Schumock, Glen T; Pickard, A Simon

    2012-07-01

    Recent studies have suggested an increase in the number of retracted scientific publications. It is unclear how broadly the issue of misleading and fraudulent publications pertains to retractions of drug therapy studies. Therefore, we sought to determine the trends and factors associated with retracted publications in drug therapy literature. A PubMed search was conducted to identify retracted drug therapy articles published from 2000-2011. Articles were grouped according to reason for retraction, which was classified as scientific misconduct or error. Scientific misconduct was further divided into data fabrication, data falsification, questions of data veracity, unethical author conduct, and plagiarism. Error was defined as duplicate publication, scientific mistake, journal error, or unstated reasons. Additional data were extracted from the retracted articles, including type of article, funding source, author information, therapeutic area, and retraction issue. A total of 742 retractions were identified from 2000-2011 in the general biomedical literature, and 102 drug studies met our inclusion criteria. Of these, 73 articles (72%) were retracted for a reason classified as scientific misconduct, whereas 29 articles (28%) were retracted for error. Among the 73 articles classified as scientific misconduct, those classified as unethical author conduct (32 articles [44%]) and data fabrication (24 articles [33%]) constituted the majority. The median time from publication of the original article to retraction was 31 months (range 1-130). Fifty percent of retracted articles did not state a funding source, whereas pharmaceutical manufacturer funding accounted for only 13 articles (13%) analyzed. Many retractions were due to repeat offenses by a small number of authors, with nearly 40% of the retracted studies associated with two individuals. We found that a greater proportion of drug therapy articles were retracted for reasons of misconduct and fraud compared with other

  11. Clinical image: MRI during migraine with aura

    Energy Technology Data Exchange (ETDEWEB)

    McNeal, A.C. [Brooklyn VA Medical Center, NY (United States)

    1996-03-01

    Migraine refers to severe headaches that are usually unilateral, throbbing, and associated with nausea, vomiting, photophobia, and phonophobia. Migraine with aura (formerly called {open_quotes}classic migraine{close_quotes}) consists of the headache preceded or accompanied by neurological dysfunction. This dysfunction (aura) usually involves visual and sensory symptoms. The patient described herein experienced migraine with aura. MRI during and after the attack showed a reversible abnormality of the right posterior cerebral artery, with no parenchymal lesions. This appears to be the first report of abnormal MR vascular imaging during migraine with aura. 10 refs., 2 figs.

  12. Retractions in cancer research: a systematic survey.

    Science.gov (United States)

    Bozzo, Anthony; Bali, Kamal; Evaniew, Nathan; Ghert, Michelle

    2017-01-01

    The annual number of retracted publications in the scientific literature is rapidly increasing. The objective of this study was to determine the frequency and reason for retraction of cancer publications and to determine how journals in the cancer field handle retracted articles. We searched three online databases (MEDLINE, Embase, The Cochrane Library) from database inception until 2015 for retracted journal publications related to cancer research. For each article, the reason for retraction was categorized as plagiarism, duplicate publication, fraud, error, authorship issues, or ethical issues. Accessibility of the retracted article was defined as intact, removed, or available but with a watermark over each page. Descriptive data was collected on each retracted article including number of citations, journal name and impact factor, study design, and time between publication and retraction. The publications were screened in duplicated and two reviewers extracted and categorized data. Following database search and article screening, we identified 571 retracted cancer publications. The majority (76.4%) of cancer retractions were issued in the most recent decade, with 16.6 and 6.7% of the retractions in the prior two decades respectively. Retractions were issued by journals with impact factors ranging from 0 (discontinued) to 55.8. The average impact factor was 5.4 (median 3.54, IQR 1.8-5.5). On average, a retracted article was cited 45 times (median 18, IQR 6-51), with a range of 0-742. Reasons for retraction include plagiarism (14.4%), fraud (28.4%), duplicate publication (18.2%), error (24.2%), authorship issues (3.9%), and ethical issues (2.1%). The reason for retraction was not stated in 9.8% of cases. Twenty-nine percent of retracted articles remain available online in their original form. Retractions in cancer research are increasing in frequency at a similar rate to all biomedical research retractions. Cancer retractions are largely due to academic misconduct

  13. A survey of retracted articles in dentistry.

    Science.gov (United States)

    Nogueira, Túlio Eduardo; Gonçalves, Andréia Souza; Leles, Cláudio Rodrigues; Batista, Aline Carvalho; Costa, Luciane Rezende

    2017-07-06

    Publication retraction is a mechanism to preserve the scientific literature against publications that contain seriously flawed or erroneous data, redundant publication, plagiarism, unethical research, and other features that compromise the integrity of science. An increase in the occurrence of retractions in recent years has been reported. Nevertheless, there is scarce information on this topic concerning publications in dentistry and related specialties. Thus, this study aimed to investigate retracted papers published in dental journals. Data collection included an exploratory search in PubMed and a specific search in SCImago Journal Rank indexed journals, complemented by the cases reported on the Retraction Watch website and in PubMed. All 167 dental journals included in SCImago were searched for identification of retracted articles up to March 2016. The selected retracted articles and their corresponding retraction notices were recorded and assessed for classification according to the reason for retraction and other additional information. Forty of the 167 journals scrutinised at SCImago (23.9%) had at least one retracted article, and four additional journals were identified from the Retraction Watch website. A total of 72 retracted found were retracted for the reasons: redundant publication (20.8%), plagiarism (18.1%), misconduct (13.8%), overlap (13.6%) and honest error (9.7%). Higher number of retractions were reported in those journals with cites/doc <2.0-n = 49 (74.2%). The types of studies were mainly laboratory studies (34.7%), case reports (22.2%) and review articles (13.9%). The approach to ethical problems in papers published in dental scientific journals is still incipient; retractions were mostly due to the authors' malpractice and were more frequently related to journals with less impact.

  14. Hemiplegic migraine aura begins with cerebral hypoperfusion

    DEFF Research Database (Denmark)

    Hansen, Jakob M; Schytz, Henrik W; Larsen, Vibeke A

    2011-01-01

    Imaging studies of spontaneous migraine aura have proved challenging because of the episodic and unpredictable nature of migraine attacks. Two patients with signs of acute ischemic stroke were evaluated for thrombolysis and turned out to suffer from familial hemiplegic migraine. It was possible...... to record the early phase of the hemiplegic aura with computed tomography with perfusion sequences and magnetic resonance imaging. We found cerebral hypoperfusion in the relevant cortical areas within the first hour after onset of aura symptoms. This report supports the concept that migraine aura across...... the migraine spectrum is caused by similar mechanisms. In a setting with efficient cooperation between headache and stroke neurologists, thrombolysis centers provide the set-up and opportunity to record aura symptoms at an early phase. Furthermore, in the time of ready access to acute systemic thrombolysis...

  15. [Migrainous aura subtypes in hospitalized children].

    Science.gov (United States)

    Biedroń, Agnieszka; Steczkowska, Małgorzata; Zajac, Anna; Stolarska, Urszula; Kroczka, Sławomir

    2009-01-01

    Migraine with aura is characterized by reversible focal neurological symptoms preceding or accompanying headache. Visual aura is the most common type of aura and its patognomic symptoms are scintillating fortification migrating across the visual field or scintillating scotoma. However, the symptoms are not always so typical and clinical doubts are greater when negative symptoms (loss of vision, numbness or paresis) are present. Differential diagnosis of migraine with aura includes in the first place transient ischemic attack (TIA) as well as epilepsy. Diagnosis of migraine in the developmental age is more difficult and associated with unprecise description of the symptoms. Thorough history taking is crucial in migraine diagnosis and following management. Knowledge of migraine with aura symptoms, clinical differences associated with developmental age and features enabling differentiation with other disorders imitating migraine is very important. Description of aura types and characteristics of migraine headache and their accompanying symptoms in children. 30 children were included, aged 8-17 years (mean 13,6 years), hospitalized at Department of Pediatric Neurology Chair of Pediatric and Adolescent Neurology, Jagiellonian University in 14 months of years 2008 and 2009. Clinical analysis was based on inquiry addressed to the patients and their parents. Migraine with visual aura was established in 9 patients, with somatosensory aura in 4, visual and somatosensory in 5, visual and dysphasic in 1, visual, somatosensory and dysphasic in 5, somatosensory and dysphasic in 2 and basilar type migraine in 4 patients. Consequently, symptoms of visual aura were present in 20/30 patients, in 9 of them it was the only type of aura and in 11 coexisted with other aura types. In more than half cases it manifested as simple visual phenomenons (spots, dots, frills, lines). Blurred vision was found in 5 patients (bilateral in 3, unilateral in 3) and hemianopia in 2 (bilateral in aura

  16. Clinical characteristics of the eardrum retraction pocket

    Directory of Open Access Journals (Sweden)

    Ješić Snežana

    2003-01-01

    Full Text Available Development of the eardrum retraction pocket, as pathologic finding, depends on Eustachian tube dysfunction, onset of the middle ear infection and site of development of retraction on the eardrum. The study is aimed at: 1. Determining the incidence of eardrum retraction pocket and cholesteatoma within it, as well as at the degree of eardrum retraction; 2. Determining of association between eardrum retraction pocket and changes of the eardrum mucosaand parstensa of the tympanic membrane; 3. Determining of onset and intensity of the bone destruction in eardrum retraction pocket; 4. Examining of Eustachian tube function based on time of mucocilliary transport according to the type of the eardrum retraction pocket. The study is based on the retrospective analysis of the results obtained from the patients treated at the Institute of Oto-Rhino-Laryngology and Maxillofacial Surgery Clinical Centre of Serbia in Belgrade for the diagnosis of the chronic suppurative otitis who underwent otosurgical procedures during the six-year period, from 1996-2001. In our series of 540 patients subjected to otosurgical treatment, the incidence of the retraction pocket of the eardrum was 11.23%. Onset of more severe degree of eardrum retraction was most frequent in the attic. Cholesteatoma was detected in 82.2% of patients of the group with the attic-retraction pocket of the eardrum, as well as in 25% of patients of the group of tensa-sinus retraction pocket of the eardrum. Atrophic changes of the tympanic membrane pars tensa were detected in almost all tensa-sinus retraction pockets of the eardrum. Approximately one half of the attic-retraction pockets of the eardrum were accompanied by eardrum atrophy. Bone destruction of the auditory ossicles was limited to the long process of incus and superior structures of stapes. Time of the mucocilliary transport was significantly longer (p<0.01 in attic-retraction pocket of the eardrum than in tensa-sinus retraction pocket of

  17. Migraine with prolonged aura: phenotype and treatment.

    Science.gov (United States)

    Viana, Michele; Afridi, Shazia

    2018-01-01

    We review the published literature on migraine with prolonged aura (PA), specifically with regards to the phenotype and treatment options. PA is not uncommon. A recent study found that about 17% of migraine auras are prolonged and that 26% of patients with migraine with aura have experienced at least one PA. The characteristics of PA are similar to most typical auras with the exception of a higher number of aura symptoms (in particular sensory and/or dysphasic). There are no well-established treatments at present which target the aura component of migraine. Other than case reports, there have been open-label studies of lamotrigine and greater occipital nerve blocks. The only randomised, blinded, controlled trial to date has been of nasal ketamine showing some reduction in aura severity but not duration. A small open-labelled pilot study of amiloride was also promising. Larger randomised, controlled trials are needed to establish whether any of the existing or novel compounds mentioned are significantly effective and safe.

  18. Topological stability through extremely tame retractions

    DEFF Research Database (Denmark)

    Feragen, Aasa

    2012-01-01

    not know whether f will be topologically stable if we can find a pair of continuous retractions r and s. The class of extremely tame (E-tame) retractions, introduced by du Plessis and Wall, are defined by their nice geometric properties, which are sufficient to ensure that f is topologically stable....... In this article, we present the E-tame retractions and their relation with topological stability, survey recent results by the author concerning their construction, and illustrate the use of our techniques by constructing E-tame retractions for certain germs belonging to the E- and Z-series of singularities....

  19. Laser Gingival Retraction: A Quantitative Assessment

    Science.gov (United States)

    Krishna Ch, Vamsi; Gupta, Nidhi; Reddy, K. Mahendranadh; Sekhar, N. Chandra; Aditya, Venkata; Reddy, G.V.K. Mohan

    2013-01-01

    Background: Proper gingival retraction improves the prognosis of crowns and bridges with sub gingival finishlines.Use of lasers assists the operator to achieve proper retraction with good clinical results. Aims: The present study was intended to assess the amount of lateral gingival retraction achieved quantitatively by using diode lasers. Settings and Design: Study was carried on 20 patients attended to a dental institution that underwent root canal treatment and indicated for fabrication of crowns. Material and Methods: Gingival retraction was carried out on 20 teeth and elastomeric impressions were obtained. Models retrieved from the impressions were sectioned and the lateral distance between finish line and the marginal gingival was measured using tool makers microscope. Retraction was measured in mid buccal, mesio buccal and disto buccal regions. Statistical Analysis: The values obtained were used to calculate the mean lateral retraction in microns. Results: Mean retraction values of 399.5 μm, 445.5 μm and 422.5μm were obtained in mid buccal, mesio buccal and disto buccal regions respectively. Conclusions: Gingival Retraction achieved was closer to the thickness of sulcular epithelium and greater than the minimum required retraction of 200um. PMID:24086914

  20. Aura, Self, and Aesthetic Experience

    Directory of Open Access Journals (Sweden)

    Marshall Battani

    2011-01-01

    Full Text Available Aesthetic experiences are generated in encounters with cultural objects and such experiences are marked by the free play of cognitive and numinous experience unstructured by concepts. Kant’s famous three types of pleasure, made infamous in social theory by Pierre Bourdieu, are examined in relation to the critical theoretical concept of aura, the social psychology of “flow,” and cognitive explanations of perception to explain experience in aesthetic fields. Theories of aesthetic experience developed at the crossroad of critical social thought and cognitive science hold promise for a social analysis able to avoid the usual sociological pitfalls of either ignoring aesthetics or reducing it to structurally determined differences of taste.

  1. Migraine aura symptoms: Duration, succession and temporal relationship to headache.

    Science.gov (United States)

    Viana, Michele; Linde, Mattias; Sances, Grazia; Ghiotto, Natascia; Guaschino, Elena; Allena, Marta; Terrazzino, Salvatore; Nappi, Giuseppe; Goadsby, Peter J; Tassorelli, Cristina

    2016-04-01

    As there are no biological markers, a detailed description of symptoms, particularly temporal characteristics, is crucial when diagnosing migraine aura. Hitherto these temporal aspects have not been studied in detail. We conducted a prospective diary-aided study of the duration and the succession of aura symptoms and their temporal relationship with headache. Fifty-four patients completed the study recording in a diary the characteristics of three consecutive auras ( ITALIC! n = 162 auras). The median duration of visual, sensory and dysphasic symptoms were 30, 20 and 20 minutes, respectively. Visual symptoms lasted for more than one hour in 14% of auras ( ITALIC! n = 158), sensory symptoms in 21% of auras ( ITALIC! n = 52), and dysphasic symptoms in 17% of auras ( ITALIC! n = 18). Twenty-six percent of patients had at least one aura out of three with one symptom lasting for more than one hour. In aura with multiple symptoms the subsequent symptom, second versus first one or third versus second, might either start simultaneously (34 and 18%), during (37 and 55%), with the end (5 and 9%), or after (24 and 18%) the previous aura symptom. The headache phase started before the aura (9%), simultaneously with the onset of aura (14%), during the aura (26%), simultaneously with the end of aura (15%) or after the end of aura (36%). We provide data to suggest that symptoms may last longer than one hour in a relevant proportion of auras or migraine with aura patients, and that there is a high variability of scenarios in terms of time relationship among aura symptoms and between aura and headache. © International Headache Society 2015.

  2. TCSP TICOSONDE-AURA 2005 V1

    Data.gov (United States)

    National Aeronautics and Space Administration — The Ticosonde/Aura-TCSP 2005 radiosonde data set consists of 4 soundings per day (00, 06, 12 and 18 UT) launched from Juan Santamaria International Airport, WMO...

  3. Cluster-like headache aura status

    NARCIS (Netherlands)

    Langedijk, M; van der Naalt, J; Luijckx, GJ; De Keyser, J

    We describe a patient with successive attacks (40 to 90 minutes) of cluster-like headache associated with aphasia, and contralateral hemihypesthesia and hemiplegia. The condition can best be described as cluster-like headache aura status.

  4. Retraction

    Directory of Open Access Journals (Sweden)

    Singhai R

    2012-03-01

    Full Text Available The Editor-in-Chief and Publisher of Breast Cancer: Targets and Therapy have been alerted to unacceptable levels of duplication with previously published papers. All four papers were submitted by Dr Rajeev Singhai.It is worth noting that all papers were peer-reviewed by a minimum of two peer-reviewers and the Editor-in-Chief of Breast Cancer: Targets and Therapy before publication. The papers concerned are:Patil VW, Tayade MB, Pingale SA, et al. The p53 breast cancer tissue biomarker in Indian women. Breast Cancer: Targets and Therapy. 2011;3:71–78.Singhai R, Patil AV, Patil VW. Cancer biomarker HER-2/neu in breast cancer in Indian women. Breast Cancer: Targets and Therapy. 2011;3:21–26.Patil AV, Bhamre RS, Singhai R, Tayade MB, Patil VW. Estrogen receptor (ER and progesterone receptor (PgR in breast cancer of Indian women. Breast Cancer: Targets and Therapy. 2011;3:27–33.Patil VW, Singhai R, Patil AV, Gurav PD. Triple-negative (ER, PgR, HER-2/neu breast cancer in Indian women. Breast Cancer: Targets and Therapy. 2011;3:9–19.

  5. The Problem of Retraction in Critical Discussion

    NARCIS (Netherlands)

    Krabbe, Erik C. W.

    2001-01-01

    In many contexts a retraction of commitment is frowned upon. For instance, it is not appreciated, generally, if one withdraws a promise or denies an earlier statement. Critical discussion, too, can easily be disrupted by retractions, if these occur too frequently and at critical points. But on the

  6. Gingival Retraction Methods: A Systematic Review.

    Science.gov (United States)

    Tabassum, Sadia; Adnan, Samira; Khan, Farhan Raza

    2017-12-01

    The aim of this systematic review was to assess the gingival retraction methods in terms of the amount of gingival retraction achieved and changes observed in various clinical parameters: gingival index (GI), plaque index (PI), probing depth (PD), and attachment loss (AL). Data sources included three major databases, PubMed, CINAHL plus (Ebsco), and Cochrane, along with hand search. Search was made using the key terms in different permutations of gingival retraction* AND displacement method* OR technique* OR agents OR material* OR medicament*. The initial search results yielded 145 articles which were narrowed down to 10 articles using a strict eligibility criteria of including clinical trials or experimental studies on gingival retraction methods with the amount of tooth structure gained and assessment of clinical parameters as the outcomes conducted on human permanent teeth only. Gingival retraction was measured in 6/10 studies whereas the clinical parameters were assessed in 5/10 studies. The total number of teeth assessed in the 10 included studies was 400. The most common method used for gingival retraction was chemomechanical. The results were heterogeneous with regards to the outcome variables. No method seemed to be significantly superior to the other in terms of gingival retraction achieved. Clinical parameters were not significantly affected by the gingival retraction method. © 2016 by the American College of Prosthodontists.

  7. Retraction of Hard, Lozano, and Tversky (2006)

    Science.gov (United States)

    Hard, B. M.; Lozano, S. C.; Tversky, B.

    2008-01-01

    Reports a retraction of "Hierarchical encoding of behavior: Translating perception into action" by Bridgette Martin Hard, Sandra C. Lozano and Barbara Tversky (Journal of Experimental Psychology: General, 2006[Nov], Vol 135[4], 588-608). All authors retract this article. Co-author Tversky and co-author Hard believe that the research results cannot…

  8. Retracted: FLT3: beyond good and evil.

    Science.gov (United States)

    Lagunas-Rangel, Francisco Alejandro; Cortes-Penagos, Carlos; Viveros-Sandoval, Martha Eva

    2016-07-29

    The above article, published online on 29 July 2016 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the Journal Editor in Chief, Journal Production Manager, and John Wiley & Sons, Ltd. The retraction has been agreed due to 48% similar significant between this article and an article published in Nature Reviews Cancer journal. Copyright © 2016 John Wiley & Sons, Ltd.

  9. Retracted: Inhibition of Corneal Neovascularization by ...

    African Journals Online (AJOL)

    This article previously published in Volume 15 Issue 2 of this journal in February 2016 has been retracted in line with the guidelines from the Committee on Publication Ethics (COPE, http://publicationethics.org/resources/guidelines). Retracted: Zhan W, Zhu J, Zhang Y. Inhibition of corneal neovascularization by ...

  10. 14 CFR 27.729 - Retracting mechanism.

    Science.gov (United States)

    2010-01-01

    ... at any airspeed up to the design maximum landing gear extended speed. (b) Landing gear lock. A... STANDARDS: NORMAL CATEGORY ROTORCRAFT Design and Construction Landing Gear § 27.729 Retracting mechanism..., retracting mechansim, wheel-well doors, and supporting structure must be designed for— (1) The loads...

  11. 14 CFR 29.729 - Retracting mechanism.

    Science.gov (United States)

    2010-01-01

    ... at any airspeed up to the design maximum landing gear extended speed. (b) Landing gear lock. A... STANDARDS: TRANSPORT CATEGORY ROTORCRAFT Design and Construction Landing Gear § 29.729 Retracting mechanism..., retracting mechanism, wheel well doors, and supporting structure must be designed for— (1) The loads...

  12. Can migraine aura be provoked experimentally? A systematic review of potential methods for the provocation of migraine aura

    DEFF Research Database (Denmark)

    Lindblad, Marianne; Hougaard, Anders; Amin, Faisal Mohammad

    2017-01-01

    Background The nature of the migraine aura and its role in migraine pathophysiology is incompletely understood. In particular, the mechanisms underlying aura initiation and the causal relation between aura and headache are unknown. The scientific investigation of aura in patients is only possible...... if aura can be triggered. This paper reviews potential methods for the experimental provocation of migraine aura. Methods We systematically searched PubMed for studies of experimental migraine provocation, including case reports of patients with aura and reports of the occurrence of aura following...... exposure to any kind of suspected trigger. Results We identified 21 provocation studies, using 13 different prospective provocation methods, and 34 case reports. In the prospective studies, aura were reported following the administration of intravenous and sublingual glyceryl trinitrate, visual stimulation...

  13. Retraction of Neurosurgical Publications: A Systematic Review.

    Science.gov (United States)

    Wang, Justin; Ku, Jerry C; Alotaibi, Naif M; Rutka, James T

    2017-07-01

    Despite the increasing awareness of scientific fraud, no attempt has been made to assess its prevalence in neurosurgery. The aim of our review was to assess the chronologic trend, reasons, research type/design, and country of origin of retracted neurosurgical publications. Three independent reviewers searched the EMBASE and MEDLINE databases using neurosurgical keywords for retracted articles from 1995 to 2016. Archives of retracted articles (retractionwatch.com) and the independent Web sites of neurosurgical journals were also searched. Data including the journal, impact factor, reason for retraction, country of origin, and citations were extracted. A total of 97 studies were included for data extraction. Journal impact factor ranged from 0.57 to 35.03. Most studies (61) were retracted within the last 5 years. The most common reason for retraction was because of a duplicated publication found elsewhere (26), followed closely by plagiarism (22), or presenting fraudulent data (14). Other reasons included scientific errors/mistakes, author misattribution, and compromised peer review. Articles originated from several countries and some were widely cited. Retractions of neurosurgical publications are increasing significantly, mostly because of issues of academic integrity, including duplicate publishing and plagiarism. Implementation of more transparent data-sharing repositories and thorough screening of data before manuscript submission, as well as additional educational programs for new researchers, may help mitigate these issues in the future. Copyright © 2017 Elsevier Inc. All rights reserved.

  14. Characterization of consistent triggers of migraine with aura

    DEFF Research Database (Denmark)

    Hauge, Anne Werner; Kirchmann, Malene; Olesen, Jes

    2011-01-01

    The aim of the present study was to characterize perceived consistent triggers of migraine with aura (MA).......The aim of the present study was to characterize perceived consistent triggers of migraine with aura (MA)....

  15. Retracted: Exploring resident reflections to understand burnout.

    Science.gov (United States)

    Winkel, Abigail Ford; Jakalow, Holli; Benton, Laura; Moss, Haley; Mitchell, Lauren; Feldman, Nathalie

    2016-04-05

    Retraction: Winkel, A. F., Jakalow, H., Benton, L., Moss, H., Mitchell, L. and Feldman, N. (2016), Exploring resident reflections to understand burnout. The Clinical Teacher. doi: 10.1111/tct.12513 The above article, published online on 5th April 2016 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the authors, the journal Co-Editors, and John Wiley & Sons Ltd. The retraction has been agreed due to a change in the status of the research project's Institutional Review Board approval, leading to permission to use some of the data in this article being revoked. © 2016 John Wiley & Sons Ltd.

  16. EOS Aura and Future Satellite Studies of the Ozone Layer

    Science.gov (United States)

    Schoeberl, Mark R.

    2007-01-01

    The EOS Aura mission, launched in 2004, provides a comprehensive assessment of the stratospheric dynamics and chemistry. This talk will focus on results from Aura including the chemistry of polar ozone depletion. The data from Aura can be directly linked to UARS data to produce long term trends in stratospheric trace gases.

  17. Study on Aeroacoustic Noise Characteristic of Retractable Aerial Refueling Assembly

    Science.gov (United States)

    2015-11-27

    Undergraduate Student Paper Postgraduate Student Paper Study on Aeroacoustic Noise Characteristic of Retractable Aerial Refueling Assembly ...The aeroacoustic noise influence of retractable assembly on aircraft surface is researched. Based on a smooth surface airplane without retractable... assembly , aeroacoustic noise is calculated and compared with the airplane contains a retractable assembly . The change of noise and the distribution of

  18. Trigger factors in migraine with aura

    DEFF Research Database (Denmark)

    Hauge, A W; Kirchmann, M; Olesen, J

    2010-01-01

    The aim of the present study was to identify trigger factors in migraine with aura (MA). A total of 629 MA patients representative of the Danish population were sent a questionnaire listing 16 trigger factors thought to be relevant as well as space for free text. Distinction was made between...... attacks with or without aura within each patient. The questionnaire was returned by 522 patients of whom 347 had current MA attacks. In total 80% with current attacks (278/347) indicated that at least one factor triggered their migraine, and 67% (187/278) in this group indicated that they were aware...... of at least one factor often or always giving rise to an attack of MA. Forty-one per cent (113/278) had co-occurring attacks of migraine without aura (MO). Stress (following stress), bright light, intense emotional influences, stress (during stress) and sleeping too much or too little were the trigger factors...

  19. Rare Complications of Migraine With Aura.

    Science.gov (United States)

    Plato, Brian M

    2016-09-01

    To provide a review of the diagnostic criteria, pathophysiology, and potential treatments of the complications of migraine as identified by the International Classification of Headache Disorders 3β, with the exception of status migrainosus. Migraine with aura may be associated with the onset of rare, but significantly disabling neurological symptoms. This review provides an overview of the associated complications that may arise from migraine with aura. The complications of migraine that arise from migraine aura are infrequently encountered in clinical practice; however, they can be severely disabling for patients. As these conditions are encountered, thorough diagnostic evaluation is necessary. In some cases, it may be difficult to find a consistently reliable therapeutic option for these patients; however, as more cases enter the literature, a greater understanding of these conditions and how to treat them may arise. © 2016 American Headache Society.

  20. A retractable barb needle for drug darts

    Directory of Open Access Journals (Sweden)

    G.L. van Rooyen

    1973-07-01

    Full Text Available The mechanism and action of a new retractable barbneedle for drug darts are described. This dart needle is particularly successful in obviating unnecessary flight reactions andtrauma in darted animals, and facilitates the complete injection of the drug dose before the barb is retracted and the dart is dislogded from the animal. The whole process is completed within a few seconds and the expended dart can usually be retrieved in the immediate vicinity where the animal was darted.

  1. Migraine with visual aura associated with thicker visual cortex

    DEFF Research Database (Denmark)

    Gaist, David; Hougaard, Anders; Garde, Ellen

    2018-01-01

    Until recent years it was believed that migraine with aura was a disorder causing intermittent neurological symptoms, with no impact on brain structure. However, recent MRI studies have reported increased cortical thickness of visual and somatosensory areas in patients with migraine with aura...... the regions of interest and active migraine, or number of lifetime aura attacks. Migraine with aura discordant twin pairs (n = 30) only differed in mean thickness of V2 (0.039 mm, 95% CI 0.005 to 0.074). In conclusion, females with migraine with aura have a thicker cortex corresponding to visual areas and our...

  2. Hemiplegic migraine aura begins with cerebral hypoperfusion

    DEFF Research Database (Denmark)

    Hansen, Jakob M; Schytz, Henrik W; Larsen, Vibeke A

    2011-01-01

    Imaging studies of spontaneous migraine aura have proved challenging because of the episodic and unpredictable nature of migraine attacks. Two patients with signs of acute ischemic stroke were evaluated for thrombolysis and turned out to suffer from familial hemiplegic migraine. It was possible t...

  3. Can migraine aura be provoked experimentally? A systematic review of potential methods for the provocation of migraine aura.

    Science.gov (United States)

    Lindblad, Marianne; Hougaard, Anders; Amin, Faisal Mohammad; Ashina, Messoud

    2017-01-01

    Background The nature of the migraine aura and its role in migraine pathophysiology is incompletely understood. In particular, the mechanisms underlying aura initiation and the causal relation between aura and headache are unknown. The scientific investigation of aura in patients is only possible if aura can be triggered. This paper reviews potential methods for the experimental provocation of migraine aura. Methods We systematically searched PubMed for studies of experimental migraine provocation, including case reports of patients with aura and reports of the occurrence of aura following exposure to any kind of suspected trigger. Results We identified 21 provocation studies, using 13 different prospective provocation methods, and 34 case reports. In the prospective studies, aura were reported following the administration of intravenous and sublingual glyceryl trinitrate, visual stimulation, physical activity, calcitonin gene-related peptide infusion, chocolate ingestion, and the intravenous injection of insulin. In addition, carotid artery puncture has consistently been reported as a trigger of aura. Conclusions No safe and efficient method for aura provocation exists at present, but several approaches could prove useful for this purpose.

  4. A Proof Of Existence Of Particle-like Solutions Of Einstein Dirac Equations

    CERN Document Server

    Bird, E J

    2005-01-01

    We prove existence of a ground state particle-like solution to the Einstein-Dirac equations: a b ′= 1&parl0;r Ar&parr0; -wTr +m&parl0;A r&parr0; wT r- m&parl0; Ar&parr0; -1&parl0;rA r&parr0; ˙a b A′r= 1- Ar r- 16pwr T2r a2r+b 2r T′r=T rA r-1 2rAr -16pwT3r &parl0;a2r +b2r&parr0; 2rAr +32pT2r ab2r2 Ar +16pmT2r a2r -b2r 2rAr By a ground state particle-like solution we mean a solution of the above equations that satisfies the constraints: limr→∞ r1-Ar <∞lim r- ∞Tr <∞0∞ &parl0;a2r +b2r&parr0; TAdr<∞ .

  5. A new method for rapid Canine retraction

    Directory of Open Access Journals (Sweden)

    "Khavari A

    2001-06-01

    Full Text Available Distraction osteogenesis method (Do in bone lengthening and rapid midpalatal expansion have shown the great ability of osteognic tissues for rapid bone formation under distraction force and special protocol with optimum rate of one millimeter per day. Periodontal membrane of teeth (PDM is the extension of periostium in the alveolar socked. Orthodontic force distracts PDM fibers in the tension side and then bone formation will begin.Objects: Rapid retraction of canine tooth into extraction space of first premolar by DO protocol in order to show the ability of the PDM in rapid bone formation. The other objective was reducing total orthodontic treatment time of extraction cases.Patients and Methods: Tweleve maxillary canines in six patients were retracted rapidly in three weeks by a custom-made tooth-born appliance. Radiographic records were taken to evaluate the effects of heavy applied force on canine and anchorage teeth.Results: Average retraction was 7.05 mm in three weeks (2.35 mm/week. Canines rotated distal- in by mean 3.5 degrees.Anchorage loss was from 0 to 0.8 mm with average of 0.3 mm.Root resorption of canines was negligible, and was not significant clinically. Periodontium was normal after rapid retraction. No hazard for pulp vitality was observed.Discussion: PDM responded well to heavy distraction force by Do protocol. Rapid canine retraction seems to be a safe method and can considerabely reduce orthodontic time.

  6. MSP dynamics and retraction in nematode sperm

    Science.gov (United States)

    Wolgemuth, Charles; Miao, Long; Vanderlinde, Orion; Roberts, Tom; Oster, George

    2005-03-01

    Most eukaryotic cells can crawl over surfaces. In general, this motility requires three distinct actions: polymerization at the leading edge, adhesion to the substrate, and retraction at the rear. Recent in vitro experiments with extracts from spermatozoa from the nematode Ascaris suum suggest that retraction forces are generated by depolymerization of the Major Sperm Protein (MSP) cytoskeleton. Combining polymer entropy with a simple kinetic model for disassembly I propose a model for disassembly-induced retraction that fit the in vitro experimental data. This model explains the mechanism by which deconstruction of the cytoskeleton produces the force necessary to pull the cell body forward and suggest further experiments that can test the validity of the model.

  7. Retracted: Modern Concepts for Caries Tissue Removal.

    Science.gov (United States)

    Schwendicke, Falk

    2016-02-15

    "Modern Concepts for Caries Tissue Removal", by Falk Schwendicke The above article, published online on 15 February 2016 in Wiley Online Library (http://onlinelibrary.wiley.com/doi/10.llll/jerd.12201), has been retracted by agreement between the author, Dr. Falk Schwendicke, the journal Editor-in-Chief, Dr. Harald O. Heymann, Associate Editor, Dr. Edward Swift and Wiley Periodicals, Inc. The retraction has been agreed as the article was published in advance of other companion work which should have had precedence. The article pages have been replaced by the Retraction Statement and the article condensed accordingly. Schwendicke, F. Swift, EJ. Modern concepts for caries tissue removal. Dent J Esthet Rest 2016; 28:1; DOI: 10.1111/jerd.12201. © 2016 Wiley Periodicals, Inc.

  8. Optical cryptography topology based on a three-dimensional particle-like distribution and diffractive imaging.

    Science.gov (United States)

    Chen, Wen; Chen, Xudong

    2011-05-09

    In recent years, coherent diffractive imaging has been considered as a promising alternative for information retrieval instead of conventional interference methods. Coherent diffractive imaging using the X-ray light source has opened up a new research perspective for the measurement of non-crystalline and biological specimens, and can achieve unprecedentedly high resolutions. In this paper, we show how a three-dimensional (3D) particle-like distribution and coherent diffractive imaging can be applied for a study of optical cryptography. An optical multiple-random-phase-mask encoding approach is used, and the plaintext is considered as a series of particles distributed in a 3D space. A topology concept is also introduced into the proposed optical cryptosystem. During image decryption, a retrieval algorithm is developed to extract the plaintext from the ciphertexts. In addition, security and advantages of the proposed optical cryptography topology are also analyzed. © 2011 Optical Society of America

  9. Aura-like features and photophobia in sightless migraine patients

    Directory of Open Access Journals (Sweden)

    Greice Cardoso de Carvalho Silva

    2014-12-01

    Full Text Available Migraine is a central nervous system disorder frequently expressed with paroxysmal visual dysfunctions. Objective To test the hypothesis that normal visual input is vital for the migrainous aura and photophobia. Method We studied the migraine-related visual disturbances in 8 sightless migraineurs identified among 200 visually impaired subjects. Results The main findings were the visual aura and photophobia disappearance along with blindness development, the oddness of aura – too short, colourful (e.g. blue or fire-like, auditory in nature or different in shape (round forms – and the lack of photophobia. Conclusion We propose that the aura duration should be accepted as shorter in visually impaired subjects. The changes in aura phenotype observed in our patients may be the result of both cerebral plasticity induced by the visual impairment and/or the lack of visual input per se. Integrity of visual pathways plays a key role in migraine visual aura and photophobia.

  10. Aura-like features and photophobia in sightless migraine patients.

    Science.gov (United States)

    Silva, Greice Cardoso de Carvalho; Góes, Cristiana Pessoa de Queiroz Faria; Vincent, Maurice Borges

    2014-12-01

    Migraine is a central nervous system disorder frequently expressed with paroxysmal visual dysfunctions. To test the hypothesis that normal visual input is vital for the migrainous aura and photophobia. We studied the migraine-related visual disturbances in 8 sightless migraineurs identified among 200 visually impaired subjects. The main findings were the visual aura and photophobia disappearance along with blindness development, the oddness of aura - too short, colourful (e.g. blue or fire-like), auditory in nature or different in shape (round forms) - and the lack of photophobia. We propose that the aura duration should be accepted as shorter in visually impaired subjects. The changes in aura phenotype observed in our patients may be the result of both cerebral plasticity induced by the visual impairment and/or the lack of visual input per se. Integrity of visual pathways plays a key role in migraine visual aura and photophobia.

  11. Calcitonin gene-related peptide and migraine with aura

    DEFF Research Database (Denmark)

    Hansen, Jakob M; Ashina, Messoud

    2014-01-01

    BACKGROUND: Calcitonin gene-related peptide (CGRP) is a key molecule in migraine pathophysiology. Most studies have focused on CGRP in relation to migraine without aura (MO). About one-third of migraine patients have attacks with aura (MA), and this is a systematic review of the current literature...... of CGRP in MA is less studied than in MO. Further studies of the importance of CGRP for auras and migraine are needed....

  12. Aura and Other Neurologic Dysfunction in or with Migraine.

    Science.gov (United States)

    Kissoon, Narayan R; Cutrer, Fred Michael

    2017-07-01

    Migraine can present with a wide range of neurological symptoms. Based on currently available data, the symptoms of typical migraine aura are most likely related to cortical spreading depression (CSD), and evidence supports that CSD can lead to trigeminovascular activation resulting in the headache phase of migraine. An alternative diagnosis to migraine aura should be considered if migrainous headaches present with transient neurological symptoms that have features inconsistent with aura. © 2017 American Headache Society.

  13. Depression, migraine with aura and migraine without aura: their familiality and interrelatedness.

    Science.gov (United States)

    Ball, H A; Samaan, Z; Brewster, S; Craddock, N; Gill, M; Korszun, A; Maier, W; Middleton, L; Mors, O; Owen, M J; Perry, J; Preisig, M; Rice, J; Rietschel, M; Jones, L; Jones, I; Farmer, A E; McGuffin, P

    2009-08-01

    Migraine is frequently comorbid with depression. There appear to be common aetiological factors for both disorders, but the aetiology of migraine within depressed patients, in particular the significance of aura, has been little studied. A large sample of concordantly depressed sibling pairs [the Depression-Network (DeNT) sample] was assessed as having migraine with aura (MA), migraine without aura (MoA), probable migraine or no migraine according to International Headache Society guidelines. Correlations between siblings' migraine status were used to assess the nature of familial liability to migraine. A multiple threshold isocorrelational model fit best, in which different syndromes are conceptualized as different severities of one underlying dimension rather than as having separate aetiologies. Thus, MA and MoA were found to be different forms of the same disorder, with MA occupying the more extreme end of the spectrum of liability. Implications for our understanding of the relationship between migraine and depression are discussed.

  14. On the methodology of drug trials in migraine with aura

    DEFF Research Database (Denmark)

    Hauge, Anne Werner; Hougaard, Anders; Olesen, Jes

    2010-01-01

    INTRODUCTION: Specific problems occur in clinical treatment trials for migraine with aura that differ from those encountered in treatment trials for migraine without aura. DISCUSSION: Based on our experience with four such trials, we point to a number of possible solutions and outline areas...... for future inquiry. We make recommendations about subject selection; the choice, definition and assessment of outcome measures; optimal treatments in relation to aura and headache; and we provide samples of study report forms used to record occurrence of aura and headache in this population....

  15. Effect of retraction materials on gingival health: A histopathological study

    Directory of Open Access Journals (Sweden)

    Phatale Sushma

    2010-01-01

    Full Text Available Background: Gingival retraction methods are used in dentistry for impressions of subgingival crown margins, such as, mechanical, chemical, chemicomechanical, and surgical. These methods may injure the gingival sulcular epithelium. Hence, the present study is carried out to evaluate the effect of different retraction materials, such as, Expasyl, Magic Foam Cord, and impregnated retraction cord on the gingival sulcular epithelium. Materials and Methods: This study included 30 cases of bilateral premolar extraction patients with Loe and Silness gingival index zero. Retraction materials were kept in the dry, isolated labial gingival sulcus for the required time. The retraction materials were removed by rinsing with water. Retracted gingiva of 2 - 3 mm from the gingival margin along with the tooth was extracted and the decalcified sections were microscopically studied. Data analysis: Data were analyzed by applying the chi-square test. Results: This study showed better results with retraction paste as compared to the retraction cord, and there was a significant association between retraction materials and the relative degree of injury to the sulcular epithelium. Conclusion: There is a significant association between retraction materials and gingival sulcular epithelium. It can be stated that impregnated retraction cord, may be used commonly but it needs proper tissue manipulation and is technique sensitive. Newly advanced material in the form of retraction paste like Expasyl or Magic Foam Cord was found to be better than cord as assessed histologically, it respects periodontium.

  16. Article retracted, but the message lives on.

    Science.gov (United States)

    Greitemeyer, Tobias

    2014-04-01

    The retraction of an original article aims to ensure that readers are alerted to the fact that the findings are not trustworthy. However, the present research suggests that individuals still believe in the findings of an article even though they were later told that the data were fabricated and that the article was retracted. Participants in a debriefing condition and a no-debriefing condition learned about the scientific finding of an empirical article, whereas participants in a control condition did not. Afterward, participants in the debriefing condition were told that the article had been retracted because of fabricated data. Results showed that participants in the debriefing condition were less likely to believe in the findings than participants in the no-debriefing condition but were more likely to believe in the findings than participants in the control condition, suggesting that individuals do adjust their beliefs in the perceived truth of a scientific finding after debriefing-but insufficiently. Mediational analyses revealed that the availability of generated causal arguments underlies belief perseverance. These results suggest that a retraction note of an empirical article in a scientific journal is not sufficient to ensure that readers of the original article no longer believe in the article's conclusions.

  17. RETRACTED ARTICLE: Gradually varied flow computation in ...

    Indian Academy of Sciences (India)

    Mohammad Jahandar Malekabadi

    The article ''Gradually varied flow computation in channel networks by adaptive algorithm'' (DOI 10.1007/s12046- · 017-0640-x) which has been published online has been retracted by Chief Editor of the journal Sadhana as per the. Committee on Publication Ethics (COPE) guidelines on redundant publication.

  18. Characteristics of retractions related to faked peer reviews: an overview.

    Science.gov (United States)

    Qi, Xingshun; Deng, Han; Guo, Xiaozhong

    2017-08-01

    A faked peer review is a novel cause for retraction. We reviewed the characteristics of papers retracted due to a faked peer review. All papers retracted due to faked peer reviews were identified by searching the Retraction Watch website and by conducting a manual search. All identified papers were confirmed in published journals. The information of retracted papers was collected, which primarily included publisher, journal, journal impact factor, country, as well as publication and retraction year. Overall, 250 retracted papers were identified. They were published in 48 journals by six publishers. The top 5 journals included the Journal of Vibration and Control (24.8%), Molecular Biology Reports (11.6%), Immunopharmacology and Immunotoxicology (8.0%), Tumour Biology (6.8%) and European Journal of Medical Research (6.4%). The publishers included SAGE (31%), Springer (26%), BioMed Central (18%), Elsevier (13%), Informa (11%) and LWW (1%). A minority (4%) of retracted papers were published in Science Citation Index (SCI) journals with an impact factor of >5. A majority (74.8%) of retracted papers were written by Chinese researchers. In terms of the publication year, the retracted papers were published since 2010, and the number of retracted papers peaked in 2014 (40.8%). In terms of the retraction year, the retractions started in 2012, and the number of retractions peaked in 2015 (59.6%). The number of papers retracted due to faked peer reviews differs largely among journals and countries. With the improvement of the peer review mechanism and increased education about publishing ethics, such academic misconduct may gradually disappear in future. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

  19. Pars tensa retractions without cholesteatoma in children: predictors for ossicular chain destruction, air conduction thresholds, and postoperative retractions.

    Science.gov (United States)

    Jesic, Snezana Dragoljub; Rovcanin, Lejla Hilmo; Jovicevic, Ognjen Djordjije; Jotic, Ana Dragan; Slijepcevic, Nikola Aleksandar; Ljubic, Vladimir Radoslav

    2014-07-01

    Determine predictive values of preoperative stages of pars tensa retractions, coexisting attic retraction and preoperative air conduction for ossicular destruction in isolated and combined pars tensa retraction, and predictors for successful tympanic grafts after surgery. Prospective case series study. Tertiary referral center. Forty-eight children ears without cholesteatoma were included in the study: 23 with isolated pars tensa retraction (median age, 11), 25 with combined pars tensa and attic retractions (median age, 13). Otomicroscopy, pure tone audiometry, and impedancmetry were carried out preoperatively. Three surgical procedures for isolated retractions were used: ventilation tube insertion alone or together with fascia graft or cartilage graft. Two surgical procedures for combined retractions were used: ventilation tube insertion alone and with cartilage graft. Incidence of ossicular destruction, postoperative retraction of the grafts. Stage of pars tensa retraction and preoperative air conduction thresholds do not predict long incus process defect in isolated group. Coexistence of an attic retraction predicts combined, long incus process and stapes superstructure defect (Chi = 3.943, p = 0.047, OR = 12.00). Retractions of grafts are predicted by mode of surgery, favoring cartilage graft (isolated group: Chi = 4.306, p = 0.0372,OR = 4.69; combined group Chi = 4.7836, p = 0.0287, OR = 0.1364). Stage of pars tensa retraction predicts poor outcome of fascia graft (Chi = 4.5347, p = 0.0332, OR = 12.00). Absence of correlation between stage of pars tensa retraction and air conduction thresholds with ossicular defects justifies surgical exploration of the auditory ossicles, even in lower stages of retraction. Combined ossicular defect is expected in combined retractions. The usage of cartilage graft proved to be more appropriate.

  20. OMI/Aura Level 1B Solar Irradiances V003

    Data.gov (United States)

    National Aeronautics and Space Administration — The Level-1B (L1B) Radiance Product OML1BIRR (Version-3) from the Aura-OMI is now available (http://disc.gsfc.nasa.gov/Aura/OMI/oml1birr_v003.shtml) to public from...

  1. Prevalence and characteristics of visual aura in idiopathic generalized epilepsy.

    Science.gov (United States)

    Gungor-Tuncer, Ozlem; Baykan, Betul; Altindag, Ebru; Bebek, Nerses; Gurses, Candan; Gokyigit, Aysen

    2012-12-01

    Some patients with idiopathic/genetic generalized epilepsy (IGE) experience visual aura, which can confuse the diagnosis. We sought to determine the frequency and characteristics of visual auras in IGE patients. Among the 176 IGE patients, 4 men and 7 women reported visual auras (mean age - 24 years). Syndromic diagnoses were juvenile myoclonic epilepsy in four, eyelid myoclonia with absences (EMA) in three, juvenile absence epilepsy in three, and other in one. Visual auras consisted of flashing lights, macropsia, illusional movements, and blindness. Eyelid myoclonia with absences was significantly more common in the group with visual aura (3 of 11 patients vs. 8 of 165 IGE patients; P=0.02). Furthermore, photosensitivity was found significantly more common in IGE patients with visual aura (90% vs 46% of the total IGE patients) (P=0.004). In conclusion, the visual auras do not exclude a diagnosis of IGE. The presence of visual aura in the EMA syndrome is also remarkable. Copyright © 2012 Elsevier Inc. All rights reserved.

  2. Migraine with brainstem aura: Why not a cortical origin?

    Science.gov (United States)

    Demarquay, Geneviève; Ducros, Anne; Montavont, Alexandra; Mauguiere, François

    2017-01-01

    Background Migraine with brainstem aura is defined as a migraine with aura including at least two of the following symptoms: dysarthria, vertigo, tinnitus, hypacusis, diplopia, ataxia and/or decreased level of consciousness. Aim The aim of this study is to review data coming from clinical observations and functional mapping that support the role of the cerebral cortex in the initiation of brainstem aura symptoms. Results Vertigo can result from a vestibular cortex dysfunction, while tinnitus and hypacusis can originate within the auditory cortex. Diplopia can reflect a parieto-occipital involvement. Dysarthria can be caused by dysfunctions located in precentral gyri. Ataxia can reflect abnormal processing of vestibular, sensory, or visual inputs by the parietal lobe. Alteration of consciousness can be caused by abnormal neural activation within specific consciousness networks that include prefrontal and posterior parietal cortices. Conclusion Any symptom of so-called brainstem aura can originate within the cortex. Based on these data, we suggest that brainstem aura could have a cortical origin. This hypothesis would explain the co-occurrence of typical and brainstem aura during attacks and would fit with the theory of cortical spreading depression. We propose that migraine with brainstem aura should be classified as a typical migraine aura.

  3. On the methodology of drug trials in migraine with aura

    DEFF Research Database (Denmark)

    Hauge, Anne Werner; Hougaard, Anders; Olesen, Jes

    2010-01-01

    INTRODUCTION: Specific problems occur in clinical treatment trials for migraine with aura that differ from those encountered in treatment trials for migraine without aura. DISCUSSION: Based on our experience with four such trials, we point to a number of possible solutions and outline areas...

  4. Two Patients With Visual Aura - Migraine, Epilepsy, or Migralepsy?

    Science.gov (United States)

    Hartl, Elisabeth; Rémi, Jan; Noachtar, Soheyl

    2015-09-01

    The concept of migralepsy refers to visual migraine auras that seemingly evolve into epileptic seizures. It was discussed controversially ever since and scientific proof for this entity is scarce. We report two patients with visual aura fulfilling the diagnostic criteria for migralepsy. In both patients, habitual attacks were recorded during long-term video electroencephalography (EEG) monitoring. Both patients demonstrated unilateral occipital EEG seizure patterns during their long-lasting visual aura, which eventually evolved into versive seizures. Here, we prove the epileptic origin of the visual auras, which have been misdiagnosed as migraine or migralepsy before. Additional evaluation should be considered in patients with visual aura and hints for an epileptic origin as occipital lobe epilepsy might be missed in patients diagnosed with migraine. Based on our patients, we suggest to challenge the concept of migralepsy in current classifications. © 2015 American Headache Society.

  5. RETRACTED: Menselijke vrijheid en het Christelijk geloof

    Directory of Open Access Journals (Sweden)

    Jasper Doomen

    2012-05-01

    *This article has been retracted at the request of the Editor-in-Chief. Reason: ‘The article has been retracted to straighten the academic record. It has come to light that this article has significant overlap with an article that had already appeared in Informción Filosófica, Volume 1 (2004, num. 2, pp. 251–265, entitled ‘De onverenigbaarheid van menselijke vrijheid met het christelijk geloof’. Apologies are offered to readers of the journal that this was not detected during the submission process’. The full-text of the original article (2004 is here: https://openaccess.leidenuniv.nl/handle/1887/17816

  6. [Gingival retraction paste versus gingival retraction cord for fixed prosthodontics: a systematic review].

    Science.gov (United States)

    Hong, Le-guan; Guo, Li-ping; Xue, Li-li

    2013-08-01

    To assess the efficacy of gingival retraction paste versus gingival retraction cord in fixed prosthodontics on gingiva protection, tooth preparation, clarity of the impression and plaster model, and aptness of the prosthesis. Chinese BioMedical Literature Database, VIP, China National Knowledge Infrastructure (CNKI) and Wangfang database were searched on November 15th 2012 for eligible studies. Hand-searching included references of the included studies and Chinese dental journals. Risk of bias of the included studies was assessed by 2 reviewers independently using Cochrane Collaboration's tool, and data extraction was done by the 2 reviewers. Meta analysis was performed with Revman 5.1 software. Nine randomized controlled trials, involving 1153 participants, were included. All of them had moderate risk of bias. Meta analysis revealed that gingival retraction paste had better effect on gingival health [RR=1.05, 95%CI (1.00, 1.11), P=0.04], tooth preparation [RR=1.17, 95%CI (1.07, 1.28), P=0.0008] and clarity of the impression and plaster model [RR=1.08, 95%CI (1.03, 1.13), P=0.0009] than gingival retraction cord, and the aptness of the prosthesis was as good as the cord [RR=1.07, 95%CI (0.96, 1.19), P=0.21]. The gingival retraction paste has better effect on gingival health, tooth preparation and clarity of the impression and plaster model, while the aptness of the prosthesis is as good as the cord and can be considered as a good candidate of the gingival retraction cord, but more randomized controlled trials are needed.

  7. Pure menstrual migraine with sensory aura: a case report.

    Science.gov (United States)

    Chen, Jiann-Jy; Hsu, Yung-Chu; Chen, Dem-Lion

    2012-07-01

    Hormonal changes related to the menstrual cycle have a great impact on migraines in women. Menstrual migraine attacks are almost invariably without aura. Categorizing migraines into menstrual or non-menstrual types is one way to stratify migraines without aura according to the appendix criteria of the International Classification of Headache Disorders. We report a peri-menopausal woman whose sensory aura exclusively heralded menstrual migraine. A 51-year-old woman had suffered from monthly episodic headaches since the age of 46. Before a headache, and within 1 h on the first day of her menstruation, she always experienced numbness in her entire left upper limb. After the sensory aura, migrainous headaches occurred with nausea and photophobia. In the postmenopausal period, she no longer had sensory aura, and her headache pattern changed and became less severe. Her physical and neurologic exams as well as electroencephalography, brain magnetic resonance imaging, and conventional angiography were all normal. She fulfilled the diagnosis of pure menstrual migraine with typical sensory aura. To our knowledge, this is the first formal case report of pure menstrual migraine with aura.

  8. Prospective memory is dysfunctional in migraine without aura.

    Science.gov (United States)

    Santangelo, Gabriella; Russo, Antonio; Tessitore, Alessandro; Garramone, Federica; Silvestro, Marcello; Della Mura, Maria Rosaria; Marcuccio, Laura; Fornaro, Ilaria; Trojano, Luigi; Tedeschi, Gioacchino

    2018-01-01

    Introduction Prospective memory is the ability to carry out a delayed intended action, so to maintain and retrieve future plans, goals and activities. Deficits of prospective memory negatively impact on patients and caregivers' everyday living and determine poor adherence to treatment. Since frontal regions are involved in both event- and time-based prospective memory tasks and are impaired in migraine without aura, defects of prospective memory might occur in migraine without aura patients; until now this issue has not been investigated. The aim of the current study was to explore time- versus event-based prospective memory in migraine without aura. Patients and methods Ninty-one consecutive migraine without aura patients and 84 healthy subjects were enrolled in the study. They underwent a standardized measure of prospective memory evaluating both time-based and event-based prospective memory, and the Montreal Cognitive Assessment assessing global cognitive status. Moreover, all participants completed the Beck Depression Inventory-II and a self-administered version of the Apathy Evaluation Scale, to assess severity of depressive symptoms and apathy, respectively. Results Migraine without aura and healthy subjects did not differ on demographic aspects (i.e. age, education and gender). However, individuals with migraine without aura demonstrated impaired prospective memory performance compared to healthy subjects, with a greater impairment demonstrated for the time-based tasks. Within the migraine without aura group, no significant association was found between prospective memory performance and clinical scores, apathy, and depression. Conclusions Individuals with migraine without aura experience particular difficulty executing a future intention; therefore, migraine without aura is associated with dysfunction of prospective memory.

  9. Are auras a reliable clinical indicator in medial temporal lobe epilepsy with hippocampal sclerosis?

    Science.gov (United States)

    Dupont, S; Samson, Y; Nguyen-Michel, V-H; Zavanone, C; Clémenceau, S; Miles, R; Baulac, M; Adam, C

    2015-09-01

    Medial temporal lobe epilepsy with unilateral hippocampal sclerosis (MTLE-HS) is the most frequent form of surgical temporal lobe epilepsy. In this study, it was aimed to determine whether different types of aura represent a cardinal and characteristic feature of MTLE-HS and might provide a diagnostic complement to help identify patients who will be seizure-free after surgery. All types of auras and associations of auras reported by 400 MTLE-HS patients referred for surgery were retrospectively collected and their statistical correlation with the postoperative outcome was examined in a subgroup of 305 patients who underwent surgery. A total of 876 auras were collected, classified into 12 categories. Globally, MTLE-HS patients reported widely variable auras and groupings of auras. Most common were autonomic and abdominal visceral auras, followed by psychoaffective and experiential auras; less common, but seen in 10%-15% of patients, were non-specific auras, somatosensory auras and visual auras, and least common, reported by less than 10% of patients, were auditory, gustatory, vestibular, olfactory and intellectual auras. No auras were reported in 10% of patients. 65% of patients experienced more than one type of aura (two to seven). No specific groupings of aura type were apparent. No evidence was found for correlation between postoperative outcome and (i) any category of aura, (ii) the number of categories of aura per patient and (iii) any association of categories of auras. Auras and association of auras vary widely in MTLE-HS and provide no useful insight into surgical outcome. © 2015 EAN.

  10. Why articles are retracted: a retrospective cross-sectional study of retraction notices at BioMed Central.

    Science.gov (United States)

    Moylan, Elizabeth C; Kowalczuk, Maria K

    2016-11-23

    To assess why articles are retracted from BioMed Central journals, whether retraction notices adhered to the Committee on Publication Ethics (COPE) guidelines, and are becoming more frequent as a proportion of published articles. Retrospective cross-sectional analysis of 134 retractions from January 2000 to December 2015. 134 retraction notices were published during this timeframe. Although they account for 0.07% of all articles published (190 514 excluding supplements, corrections, retractions and commissioned content), the rate of retraction is rising. COPE guidelines on retraction were adhered to in that an explicit reason for each retraction was given. However, some notices did not document who retracted the article (eight articles, 6%) and others were unclear whether the underlying cause was honest error or misconduct (15 articles, 11%). The largest proportion of notices was issued by the authors (47 articles, 35%). The majority of retractions were due to some form of misconduct (102 articles, 76%), that is, compromised peer review (44 articles, 33%), plagiarism (22 articles, 16%) and data falsification/fabrication (10 articles, 7%). Honest error accounted for 17 retractions (13%) of which 10 articles (7%) were published in error. The median number of days from publication to retraction was 337.5 days. The most common reason to retract was compromised peer review. However, the majority of these cases date to March 2015 and appear to be the result of a systematic attempt to manipulate peer review across several publishers. Retractions due to plagiarism account for the second largest category and may be reduced by screening manuscripts before publication although this is not guaranteed. Retractions due to problems with the data may be reduced by appropriate data sharing and deposition before publication. Adopting a checklist (linked to COPE guidelines) and templates for various classes of retraction notices would increase transparency of retraction notices

  11. Retraction: Statement of Retraction: Khaki-khatibi F, Yaghoubi A.R ...

    African Journals Online (AJOL)

    The article has been retracted upon the request of the corresponding author, Khaki-khatibi F, due to admitted plagiarism. However, this constitutes a violation of publication ethics. It is a breach of warranties made by the author with respect to originality upon which we received, peer-reviewed, accepted and published the ...

  12. Auditory function in Duane's retraction syndrome.

    Science.gov (United States)

    Ro, A; Chernoff, G; MacRae, D; Orton, R B; Cadera, W

    1990-01-15

    We obtained audiograms and auditory brainstem responses from 44 patients with Duane's retraction syndrome to assess the incidence and nature of hearing deficit. Of 44 patients, seven (15.9%) had evidence of hearing impairment. Three (6.8%) subjects had a temporary conductive hearing loss because of middle ear fluid, and another patient had hearing loss from Crouzon's disease. The remaining three (6.8%) patients demonstrated sensorineural hearing deficit. This hearing impairment was attributed to a cochlear lesion and not to a pontine lesion. We believe that the frequency of sensorineural hearing loss in these patients warrants hearing screening programs similar to those used for infants in neonatal intensive care units.

  13. MLS/Aura L2 Diagnostics, Miscellaneous Grid V003

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2DGM is the EOS Aura Microwave Limb Sounder (MLS) product containing the minor frame diagnostic quantities on a miscellaneous grid. These include items such as...

  14. MLS/Aura Level 2 Diagnostics, Miscellaneous Grid V004

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2DGM is the EOS Aura Microwave Limb Sounder (MLS) product containing the minor frame diagnostic quantities on a miscellaneous grid. These include items such as...

  15. MLS/Aura Level 2 Geopotential Height V004

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2GPH is the EOS Aura Microwave Limb Sounder (MLS) standard product for geopotential height derived from radiances measured by the 118 and 240 GHz radiometers. The...

  16. Auditory aura in frontal opercular epilepsy: sounds from afar.

    Science.gov (United States)

    Thompson, Stephen A; Alexopoulos, Andreas; Bingaman, William; Gonzalez-Martinez, Jorge; Bulacio, Juan; Nair, Dileep; So, Norman K

    2015-06-01

    Auditory auras are typically considered to localize to the temporal neocortex. Herein, we present two cases of frontal operculum/perisylvian epilepsy with auditory auras. Following a non-invasive evaluation, including ictal SPECT and magnetoencephalography, implicating the frontal operculum, these cases were evaluated with invasive monitoring, using stereoelectroencephalography and subdural (plus depth) electrodes, respectively. Spontaneous and electrically-induced seizures showed an ictal onset involving the frontal operculum in both cases. A typical auditory aura was triggered by stimulation of the frontal operculum in one. Resection of the frontal operculum and subjacent insula rendered one case seizure- (and aura-) free. From a hodological (network) perspective, we discuss these findings with consideration of the perisylvian and insular network(s) interconnecting the frontal and temporal lobes, and revisit the non-invasive data, specifically that of ictal SPECT.

  17. MLS/Aura Level 2 Temperature V004

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2T is the EOS Aura Microwave Limb Sounder (MLS) standard product for temperature derived from radiances measured by the 118 and 240 GHz radiometers. The current...

  18. MLS/Aura L2 Geopotential Height V002

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2GPH is the EOS Aura Microwave Limb Sounder (MLS) standard product for geopotential height derived from radiances measured by the 118 and 240 GHz radiometers. The...

  19. Aqua/Aura Spring 2017 Inclination Adjust Maneuver Series

    Science.gov (United States)

    Noyes, Thomas; Stezelberger, Shane

    2017-01-01

    This will be presented at the International Earth Science Constellation Mission Operations Working Group meeting June 13-15, 2017 to discuss the AquaAura Spring 2017 Inclination Adjust Maneuver series.

  20. MLS/Aura L2 Geopotential Height V003

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2GPH is the EOS Aura Microwave Limb Sounder (MLS) standard product for geopotential height derived from radiances measured by the 118 and 240 GHz radiometers. The...

  1. Variability of clinical features in attacks of migraine with aura

    DEFF Research Database (Denmark)

    Hansen, Jakob M; Goadsby, Peter J; Charles, Andrew C

    2016-01-01

    BACKGROUND: There is significant variability in the clinical presentation of migraine, both among patients, and between attacks in an individual patient. We examined clinical features of migraine with aura in a large group of patients enrolled in a clinical trial, and compared retrospective...... migraine attack characteristics reported upon enrollment in the trial with those recorded prospectively in the trial. METHODS: Patients with migraine (n = 267) with typical visual aura in more than 30% of their attacks were enrolled from 16 centers for a clinical trial. Upon enrollment, patients provided...... a detailed retrospective description of the clinical features of their attacks of migraine. During the trial, clinical symptoms in migraine attacks starting with aura were recorded prospectively in 861 attacks. RESULTS: Retrospectively reported visual aura symptoms were variable and often overlapping...

  2. MLS/Aura Level 2 Cloud Ice Product V004

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2IWC is the EOS Aura Microwave Limb Sounder (MLS) standard product for cloud ice water content derived from radiances measured by the 240 GHz radiometer. The...

  3. MLS/Aura L2 Cloud Ice Product V002

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2IWC is the EOS Aura Microwave Limb Sounder (MLS) standard product for cloud ice water content derived from radiances measured by the 240 GHz radiometer. The...

  4. TES/Aura L2 HDO Limb V006

    Data.gov (United States)

    National Aeronautics and Space Administration — The TES Aura L2 HDO data consist of information for one molecular species for an entire Global Survey or Special Observation. TES Level 2 data contain retrieved...

  5. TES/Aura L2 Ozone Lite Nadir V006

    Data.gov (United States)

    National Aeronautics and Space Administration — The TES Aura L2 O3 data consist of information for one molecular species for an entire Global Survey or Special Observation. TES Level 2 data contain retrieved...

  6. TES/Aura L2 HDO Lite Nadir V006

    Data.gov (United States)

    National Aeronautics and Space Administration — The TES Aura L2 HDO data consist of information for one molecular species for an entire Global Survey or Special Observation. TES Level 2 data contain retrieved...

  7. TES/Aura L2 O3 Limb V006

    Data.gov (United States)

    National Aeronautics and Space Administration — The TES Aura L2 O3 data consist of information for one molecular species for an entire Global Survey or Special Observation. TES Level 2 data contain retrieved...

  8. TES/Aura L2 NO2 Limb V006

    Data.gov (United States)

    National Aeronautics and Space Administration — The TES Aura L2 NO2 data consist of information for one molecular species for an entire Global Survey or Special Observation. TES Level 2 data contain retrieved...

  9. TES/Aura L2 HNO3 Limb V006

    Data.gov (United States)

    National Aeronautics and Space Administration — The TES Aura L2 HNO3 data consist of information for one molecular species for an entire Global Survey or Special Observation. TES Level 2 data contain retrieved...

  10. Migraine aura and related phenomena: beyond scotomata and scintillations

    Science.gov (United States)

    Vincent, MB; Hadjikhani, N

    2013-01-01

    Migraine affects the cortical physiology and may induce dysfunction both ictally and interictally. Although visual symptoms predominate during aura, other contiguous cortical areas related to less impressive symptoms are also impaired in migraine. Answers from 72.2% migraine with aura and 48.6% of migraine without aura patients on human faces and objects recognition, colour perception, proper names recalling and memory in general showed dysfunctions suggestive of prosopagnosia, dyschromatopsia, ideational apraxia, alien hand syndrome, proper name anomia or aphasia, varying in duration and severity. Symptoms frequently occurred in a successively building-up pattern fitting with the geographical distribution of the various cortical functions. When specifically inquired, migraineurs reveal less evident symptoms that are not usually considered during routine examination. Spreading depression most likely underlies the aura symptoms progression. Interictal involvement indicates that MWA and MWoA are not completely silent outside attacks, and that both subforms of migraine may share common mechanisms. PMID:17944958

  11. MLS/Aura L2 Cloud Ice Product V003

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2IWC is the EOS Aura Microwave Limb Sounder (MLS) standard product for cloud ice water content derived from radiances measured by the 240 GHz radiometer. The...

  12. Migraine aura pathophysiology: the role of blood vessels and microembolisation

    OpenAIRE

    Dalkara, Turgay; Nozari, Ala; Moskowitz, Michael A

    2010-01-01

    Migraine attacks with auras are sometimes associated with underlying hereditary or acquired cerebrovascular disorders. A unifying pathophysiological explanation linking migraine to these conditions has been diffcult to identify. On the basis of genetic and epidemiological evidence, we suggest that changes in blood vessels, hypoperfusion disorders, and microembolisation can cause neurovascular dysfunction and evoke cortical spreading depression, an event that is widely thought to underlie aura...

  13. Maintaining Aura's Orbit Requirements Under New Maneuver Operations

    Science.gov (United States)

    Johnson, Megan; Petersen, Jeremy D.

    2014-01-01

    The Earth Observing System (EOS) Afternoon Constellation consists of five member missions (GCOM-W1, Aqua, CALIPSO, CloudSat, and Aura), each of which maintain a frozen, sun-synchronous orbit with a 16-day repeating ground track that follows the Worldwide Reference System-2 (WRS-2). Under nominal science operations for Aura, the propulsion system is oriented such that the resultant thrust vector is aligned 13.493 degrees away from the velocity vector along the yaw axis. When performing orbit maintenance maneuvers, the spacecraft performs a yaw slew to align the thrust vector in the appropriate direction. A new Drag Make Up (DMU) maneuver operations scheme has been implemented for Aura alleviating the need for the 13.493 degree yaw slew. The focus of this investigation is to assess the impact that no-slew DMU maneuver operations will have on Auras Mean Local Time (MLT) which drives the required along track separation between Aura and the constellation members, as well as Auras frozen orbit properties, eccentricity and argument of perigee. Seven maneuver strategies were analyzed to determine the best operational approach. A mirror pole strategy, with maneuvers alternating at the North and South poles, was implemented operationally to minimize impact to the MLT. Additional analysis determined that the mirror pole strategy could be further modified to include frozen orbit maneuvers and thus maintain both MLT and the frozen orbit properties under no-slew operations

  14. Pediatric migraine with aura in an Italian case series.

    Science.gov (United States)

    Taga, Arens; Russo, Marco; Genovese, Antonio; Paglia, Maria Vittoria; Manzoni, Gian Camillo; Torelli, Paola

    2017-05-01

    The aim of the present study was to describe the characteristics of migraine with aura (MwA) in a case series of patients with headache onset before 12 years of age. We considered all consecutive patients referred to the Parma Headache Centre between 1975 and 2015 affected by MwA, diagnosed by our team of trained neurologists; the cases were subsequently reviewed applying the ICHD3-beta criteria. We then identified those cases with headache age-of-onset aura was the most common type of aura, followed by sensory and speech disturbances; however, these two latter aura symptoms were significantly more common among pediatric cases. In this group of patients, aura without headache was significantly less frequent (1.8 vs 5.3%); furthermore, headache had migraine characteristics in a higher proportion of cases (90.1 vs 82.6%). A family history of MwA was significantly more frequent among cases with pediatric onset (31.1 vs 16.9%). Males but not females with pediatric MwA had more frequently a comorbid migraine without aura (27.6 vs 16.8%). Among cases with pediatric onset, we did not find any significant differences between males and females. In conclusion, in our very large case series of MwA, patients with headache onset before 12 years of age seem to have a specific clinical phenotype, without significant gender differences.

  15. Clinical features of migraine aura: Results from a prospective diary-aided study.

    Science.gov (United States)

    Viana, Michele; Sances, Grazia; Linde, Mattias; Ghiotto, Natascia; Guaschino, Elena; Allena, Marta; Terrazzino, Salvatore; Nappi, Giuseppe; Goadsby, Peter J; Tassorelli, Cristina

    2017-09-01

    Background A detailed evaluation of migraine aura symptoms is crucial for classification issues and pathophysiological discussion. Few studies have focused on the detailed clinical aspects of migraine aura. Methods We conducted a prospective diary-based study of migraine aura features including presence, quality, laterality, duration of each aura symptom, their temporal succession; presence of headache and its temporal succession with aura. Results Seventy-two patients completed the study recording the characteristics of three consecutive auras ( n = 216 auras). Visual symptoms occurred in 212 (98%), sensory symptoms in 77 (36%) and dysphasic symptoms in 22 (10%). Most auras had more than one visual symptom (median 2, IQR 1-3, range 1-4). The majority of patients (56%) did not report a stereotyped aura on the three attacks with respect to visual features, the combination and/or temporal succession of the three aura symptoms. Fifty-seven percent of patients also reported a different scenario of temporal succession between aura and headache in the three attacks. Five per cent of aura symptoms were longer than four hours. Conclusion These findings show a high inter- and intravariability of migraine with aura attacks. Furthermore, they provide reliable data to enrich and clarify the spectrum of the aura phenotype.

  16. Is Duane retraction syndrome part of the VACTERL association?

    Science.gov (United States)

    Akar, Serpil; Gokyigit, Birsen; Kavadarli, Isilay; Demirok, Ahmet

    2013-01-01

    We report here a patient with type 1 Duane’s retraction syndrome and multiple congenital abnormalities as a result of the VACTERL association. The presented combination of Duane’s retraction syndrome and the VACTERL association has not been reported in the literature. The present case was instructive for reviewing the continuous spectrum of ocular anomalies that accompany the VACTERL association. PMID:23658476

  17. Publication misconduct and plagiarism retractions: a systematic, retrospective study.

    Science.gov (United States)

    Stretton, Serina; Bramich, Narelle J; Keys, Janelle R; Monk, Julie A; Ely, Julie A; Haley, Cassandra; Woolley, Mark J; Woolley, Karen L

    2012-10-01

    To investigate whether plagiarism is more prevalent in publications retracted from the medical literature when first authors are affiliated with lower-income countries versus higher-income countries. Secondary objectives included investigating other factors associated with plagiarism (e.g., national language of the first author's country affiliation, publication type, journal ranking). Systematic, controlled, retrospective, bibliometric study. Retracted publications dataset in MEDLINE (search filters: English, human, January 1966-February 2008). Retracted misconduct publications were classified according to the first author's country affiliation, country income level, and country national language, publication type, and ranking of the publishing journal. Standardised definitions and data collection tools were used; data were analysed (odds ratio [OR], 95% confidence limits [CL], chi-squared tests) by an independent academic statistician. Of the 213 retracted misconduct publications, 41.8% (89/213) were retracted for plagiarism, 52.1% (111/213) for falsification/fabrication, 2.3% (5/213) for author disputes, 2.3% (5/213) for ethical issues, and 1.4% (3/213) for unknown reasons. The OR (95% CL) of plagiarism retractions (other misconduct retractions as reference) were higher (P 1 retraction) with publications retracted for plagiarism (11.5%, 9/78) than other types of misconduct (28.9%, 24/83). This is the first study to demonstrate that publications retracted for plagiarism are significantly associated with first authors affiliated with lower-income countries. These findings have implications for developing appropriate evidence-based strategies and allocation of resources to help mitigate plagiarism misconduct.

  18. Epileptic aura and perception of self-control.

    Science.gov (United States)

    Lohse, Allan; Kjaer, Troels W; Sabers, Anne; Wolf, Peter

    2015-04-01

    The health locus of control is the subjective perception of control over one's health. It has been studied for years as one of several factors that determine patient health-related behaviors. The aim of this study was to investigate how the epileptic aura is associated with the health locus of control, anxiety, and depression. Patients were included retrospectively, based on patient records from the epilepsy monitoring unit of the Rigshospitalet University Hospital. Participants were asked about the presence and nature of auras in a semistructured interview. The Multidimensional Health Locus of Control Scale, Form C was used to evaluate the health locus of control. Three domains were evaluated: internal, where health is controlled by personal action; chance, where health is controlled by fate or luck; and powerful others, where health is controlled by the actions of others (e.g., doctors and parents). The Hospital Anxiety and Depression Scale was used to evaluate levels of anxiety and depression. Forty-nine patients, with mean age of 38years, participated in the study. Of these, 67% reported experiencing one or more auras; i.e., subjective warning signs prior to a generalized or focal seizure with an impairment in consciousness. Patients that could react to their aura prior to a seizure scored higher on the internal subscale of the Multidimensional Health Locus of Control questionnaire compared to participants that could not react to their aura. The ability to react to an aura prior to a seizure correlated positively with the internal subscale of the health locus of control. However, it did not significantly correlate with the external subscales of chance and powerful others in the health locus of control. Moreover, there was no significant relation between the ability to react to an aura prior to a seizure and the levels of anxiety or depression. Copyright © 2015 Elsevier Inc. All rights reserved.

  19. Features of aura in paediatric migraine diagnosed using the ICHD 3 beta criteria.

    Science.gov (United States)

    Balestri, Martina; Papetti, Laura; Maiorani, Daniela; Capuano, Alessandro; Tarantino, Samuela; Battan, Barbara; Vigevano, Federico; Valeriani, Massimiliano

    2017-01-01

    Background In children and adolescents, the prevalence rate of migraine with aura is 1.6%. Few studies concerning migraine with aura features in paediatric population have been reported. Aim The aim of our study was to investigate clinical features of aura in a retrospective cohort of children with migraine with aura. Furthermore, we studied whether the International Classification of Headache Disorder (ICHD) 3 beta version criteria could efficiently detect migraine with aura in a paediatric population. Results We included 164 patients who experienced aura associated with headache (mean age 9.92 ± 2.64 years). When the ICHD-II criteria were used, a final diagnosis of migraine with typical aura was obtained in 15.3% of patients, probable migraine with typical aura in 13.4%, and typical aura with headache in 61.8%, while in in 9.5% of patients the diagnosis was undetermined. According to ICHD-3 beta, we diagnosed migraine with typical aura in 77.7% of patients, probable migraine with typical aura in 13.4%, and an undetermined diagnosis in 9.5% (less than two attacks). Conclusion Aura features did not depend on age and were similar to those of adults. However, the headache could be difficult to classify if headache duration was considered. In this view, the ICHD-3 beta offers the advantage of not considering headache features, including pain duration, for the diagnosis of migraine with typical aura, thus making this diagnosis easier in children and adolescents.

  20. Dust and Debris Tolerant Retractable Cover Connector

    Science.gov (United States)

    Lewis, Mark E. (Inventor); Dokos, Adam G. (Inventor); Townsend, III, Ivan I. (Inventor); Carlson, Jeffrey W. (Inventor); Bastin, Gary L. (Inventor); Murtland, Kevin A. (Inventor)

    2017-01-01

    A debris exclusion and removal apparatus for connectors which have retractable cover configurations which include internal wafers that clean the connectors prior to mating. XXXX connectors. More particularly, embodiments relate to dust tolerant connectors. Some embodiments also relate to an intelligent connector system capable of detecting damage to or faults within a conductor and then rerouting the energy to a non-damaged spare conductor. Discussion Connectors of the present invention may be used to transfer electrical current, fluid, and gas in a wide variety of environments containing dust and other debris, wherein that debris may present substantial challenges. For example, lunar/Martian dust intrusion and/or accumulation in connectors used to transfer oxygen, hydrogen, nitrogen, etc., may lead to larger system failures as well as loss of life in extraterrestrial human exploration endeavors. Additionally, embodiments of the present invention may also be suitable for use where connectors must resist water intrusion, such as terrestrial deep water operations.

  1. Opening and retraction of particulate soap films

    Science.gov (United States)

    Timounay, Yousra; Lorenceau, Elise; Rouyer, Florence

    2015-07-01

    We study for the first time the bursting dynamics of thin liquid films laden with hydrophobic micronic particles either with free or constrained edges. We highlight that the particles can arrange in bilayer or monolayer configurations and explore a range of particles coverage from zero to random close packing. When the particles bridge the two interfaces (monolayer configuration) of free-edge films, the hole opens intermittently. For the other cases, we observe constant retraction velocities, modeled by balancing liquid and particles inertia against surface tension as in Taylor-Culick theory. But, this approach is only valid up to a critical value of particles coverage due to the interplay between the interfaces and the friction between particles.

  2. Visibility of retractions: a cross-sectional one-year study.

    Science.gov (United States)

    Decullier, Evelyne; Huot, Laure; Samson, Géraldine; Maisonneuve, Hervé

    2013-06-19

    Retraction in Medline medical literature experienced a tenfold increase between 1999 and 2009, however retraction remains a rare event since it represents 0.02% of publications. Retractions used to be handled following informal practices until they were formalized in 2009 by the Committee on Publication Ethics (COPE). The objective of our study was to describe the compliance to these guidelines. All retractions published in 2008 were identified using the Medline publication type "retraction of publication". The notices of retraction and the original articles were retrieved. For each retraction, we identified the reason for retraction, the country of affiliation of the first author, the time to retraction, the impact factor of the journal and the mention of retraction on the original article. Overall, 244 retractions were considered for analysis. Formal retraction notices could not be retrieved for 9. Of the 235 retractions available (96%), the reason was not detailed for 21 articles (9%). The most cited reasons were mistakes (28%), plagiarism (20%), fraud (14%) and overlap (11%). The original paper or its location was found for 233 retractions (95%). Of these, 22% were available with no mention of the retraction. A standard retraction form could be helpful, with a check list of major reason, leaving the editor free to provide the reader with any further information. Original articles should remain available with a clear mention of the retraction.

  3. Migraine with visual aura associated with thicker visual cortex.

    Science.gov (United States)

    Gaist, David; Hougaard, Anders; Garde, Ellen; Reislev, Nina Linde; Wiwie, Rikke; Iversen, Pernille; Madsen, Camilla Gøbel; Blaabjerg, Morten; Nielsen, Helle Hvilsted; Krøigård, Thomas; Østergaard, Kamilla; Kyvik, Kirsten Ohm; Hjelmborg, Jacob; Madsen, Kristoffer; Siebner, Hartwig Roman; Ashina, Messoud

    2018-01-18

    Until recent years it was believed that migraine with aura was a disorder causing intermittent neurological symptoms, with no impact on brain structure. However, recent MRI studies have reported increased cortical thickness of visual and somatosensory areas in patients with migraine with aura, suggesting that such structural alterations were either due to increased neuronal density in the areas involved, or a result of multiple episodes of cortical spreading depression as part of aura attacks. Subsequent studies have yielded conflicting results, possibly due to methodological reasons, e.g. small number of subjects. In this cross-sectional study, we recruited females aged 30-60 years from the nationwide Danish Twin Registry. Brain MRI of females with migraine with aura (patients), their co-twins, and unrelated migraine-free twins (controls) were performed at a single centre and assessed for cortical thickness in predefined cortical areas (V1, V2, V3A, MT, somatosensory cortex), blinded to headache diagnoses. The difference in cortical thickness between patients and controls adjusted for age, and other potential confounders was assessed. Comparisons of twin pairs discordant for migraine with aura were also performed. Comparisons were based on 166 patients, 30 co-twins, and 137 controls. Compared with controls, patients had a thicker cortex in areas V2 [adjusted mean difference 0.032 mm (95% confidence interval 0.003 to 0.061), V3A [adjusted mean difference 0.037 mm (95% confidence interval 0.008 to 0.067)], while differences in the remaining areas examined were not statistically significant [adjusted mean difference (95% confidence interval): V1 0.022 (-0.007 to 0.052); MT: 0.018 (-0.011 to 0.047); somatosensory cortex: 0.020 (-0.009 to 0.049)]. We found no association between the regions of interest and active migraine, or number of lifetime aura attacks. Migraine with aura discordant twin pairs (n = 30) only differed in mean thickness of V2 (0.039 mm, 95% CI 0

  4. Distinctive anatomical and physiological features of migraine aura revealed by 18 years of recording

    DEFF Research Database (Denmark)

    Hansen, Jakob Møller; Baca, Serapio Michael; Vanvalkenburgh, Paul

    2013-01-01

    insight into basic aura mechanisms. An individual made detailed drawings of his visual percept of migraine aura in real time during more than 1000 attacks of migraine aura without headache over 18 years. Drawings were made in a consistent fashion documenting the shape and location of the aura wavefront...... of the aura changed corresponding with the presumed propagation from the V1 to the V2 region of the occipital cortex. In some cases the visual percept disappeared for several minutes before reappearing in a distant location, providing direct evidence that the aura can be clinically 'silent'. These results...... indicate that there can be multiple distinct sites of aura initiation in a given individual and suggest that the spatial pattern of propagation in the occipital cortex is non-concentric with a variable extent of propagation. The visual percept of migraine aura changes depending on the region...

  5. Magnetic resonance angiography of intracranial and extracranial arteries in patients with spontaneous migraine without aura

    DEFF Research Database (Denmark)

    Amin, Faisal Mohammad; Asghar, Mohammad Sohail; Hougaard, Anders

    2013-01-01

    Extracranial arterial dilatation has been hypothesised to be the cause of pain in patients who have migraine without aura. To test that hypothesis, we aimed to measure extracranial and intracranial arteries during attacks of migraine without aura.......Extracranial arterial dilatation has been hypothesised to be the cause of pain in patients who have migraine without aura. To test that hypothesis, we aimed to measure extracranial and intracranial arteries during attacks of migraine without aura....

  6. Olfactory auras caused by a very focal isolated epileptic network in the amygdala

    Directory of Open Access Journals (Sweden)

    Tadashi Hamasaki

    2014-01-01

    Full Text Available Epileptic olfactory auras manifesting as simple partial seizures are rare. We report a patient who presented with olfactory auras after hemorrhage from a cavernous angioma in the left mesial temporal region. His olfactory auras persisted 12 years after two surgeries for a cavernous angioma. Intracranial depth electrodes revealed a very focal isolated epileptogenic zone in the amygdala. Olfactory auras were successfully treated by focus resection.

  7. Absence of vasoactive peptide release from brain to cerebral circulation during onset of migraine with aura

    DEFF Research Database (Denmark)

    Friberg, L; Olesen, J; Olsen, T S

    1994-01-01

    Xenon-133 injection technique. This technique is known to induce attacks of migraine with aura in many sufferers. Four patients developed aura symptoms. In three this was succeeded by throbbing headache. Typical, migraine-related, focal hypoperfusion occurred in conjunction with the aura symptoms...

  8. Do interictal microembolic signals play a role in higher cortical dysfunction during migraine aura?

    Science.gov (United States)

    Petrusic, I; Podgorac, A; Zidverc-Trajkovic, J; Radojicic, A; Jovanovic, Z; Sternic, N

    2016-05-01

    The aim of this study was to evaluate the prevalence and clinical impact of interictal microembolic signals (MES) in patients suffering from migraine with higher cortical dysfunction (HCD), such as language and memory impairment, during an aura. This study was carried out on 34 migraineurs with language and memory impairment during aura (HCD group), 31 migraineurs with only visual or visual and somatosensory symptoms during aura (Control group I), and 34 healthy controls (Control group II). We used a Doppler instrument to detect microemboli. Demographic data, disease features and the detection of MES between these groups, as well as the predictors of HCD during the aura, were analyzed. The duration of aura was longer and the frequency of aura was higher among patients with language and memory impairment during aura compared to Control group I. MES was detected in 29.4% patients from the HCD group, which was significantly higher compared to 3.2% in Control group I and 5.9% in Control group II. Regarding the absence or presence of MES, demographic and aura features were not different in the HCD subgroups. A longer duration of aura, the presence of somatosensory symptoms during the aura and the presence of interictal MES were independent predictors of HCD during the aura. The present findings indicate that HCD and MES are related in patients with migraine with aura. Further research is needed to better understand the exact pathophysiological mechanism. © International Headache Society 2015.

  9. Auras in patients with temporal lobe epilepsy and mesial temporal sclerosis.

    Science.gov (United States)

    Asadi-Pooya, Ali A; Nei, Maromi; Sharan, Ashwini; Sperling, Michael R

    2016-05-15

    We investigated auras in patients with drug-resistant temporal lobe epilepsy (TLE) and mesial temporal sclerosis (MTS). We also investigated the clinical differences between patients with MTS and abdominal auras and those with MTS and non-mesial temporal auras. All patients with drug-resistant TLE and unilateral MTS who underwent epilepsy surgery at Jefferson Comprehensive Epilepsy Center from 1986 through 2014 were evaluated. Patients with good postoperative seizure outcome were investigated. One hundred forty-nine patients (71 males and 78 females) were studied. Thirty-one patients (20.8%) reported no auras, while 29 patients (19.5%) reported abdominal aura, and 30 patients (20.1%) reported non-mesial temporal auras; 16 patients (10.7%) had sensory auras, 11 patients (7.4%) had auditory auras, and five patients (3.4%) reported visual auras. A history of preoperative tonic-clonic seizures was strongly associated with non-mesial temporal auras (odds ratio 3.8; 95% CI: 1.15-12.98; p=0.02). About one-fifth of patients who had MTS in their MRI and responded well to surgery reported auras that are historically associated with non-mesial temporal structures. However, the presence of presumed non-mesial temporal auras in a patient with MTS may herald a more widespread epileptogenic zone. Copyright © 2016 Elsevier B.V. All rights reserved.

  10. Matrix metalloproteinases during and outside of migraine attacks without aura

    DEFF Research Database (Denmark)

    Ashina, M.; Tvedskov, J.F.; Thiesen, Kerstin Lipka

    2010-01-01

    Ashina M, Tvedskov JF, Lipka K, Bilello J, Penkowa M & Olesen J. Matrix metalloproteinases during and outside of migraine attacks without aura. Cephalalgia 2009. London. ISSN 0333-1024To test the hypothesis that permeability of the blood-brain barrier (BBB) is altered during migraine attack due...... to enhanced activation of matrix metalloproteinases (MMPs), we investigated MMP-3, MMP-9 and tissue inhibitor of metalloproteases (TIMP)-1 in the external jugular vein during and outside of migraine attacks in 21 patients with migraine without aura. In addition, we measured plasma levels of several other...... and interictal plasma levels of MMP-7, -8, -10 and TIMP-2 (P > 0.05). Our data suggest that plasma MMP-9 cannot be used as a biomarker of BBB disruption in migraine without aura. Decreased MMP-3 levels are an interesting and unexpected finding warranting further investigation....

  11. Altered thalamic connectivity during spontaneous attacks of migraine without aura

    DEFF Research Database (Denmark)

    Amin, Faisal Mohammad; Hougaard, Anders; Magon, Stefano

    2017-01-01

    Background Functional connectivity of brain networks may be altered in migraine without aura patients. Functional magnetic resonance imaging (fMRI) studies have demonstrated changed activity in the thalamus, pons and cerebellum in migraineurs. Here, we investigated the thalamic, pontine and cereb......Background Functional connectivity of brain networks may be altered in migraine without aura patients. Functional magnetic resonance imaging (fMRI) studies have demonstrated changed activity in the thalamus, pons and cerebellum in migraineurs. Here, we investigated the thalamic, pontine...... and cerebellar network connectivity during spontaneous migraine attacks. Methods Seventeen patients with episodic migraine without aura underwent resting-state fMRI scan during and outside of a spontaneous migraine attack. Primary endpoint was a difference in functional connectivity between the attack...

  12. Epileptic aura and perception of self-control

    DEFF Research Database (Denmark)

    Lohse, Allan; Kjaer, Troels W; Sabers, Anne

    2015-01-01

    OBJECTIVE: The health locus of control is the subjective perception of control over one's health. It has been studied for years as one of several factors that determine patient health-related behaviors. The aim of this study was to investigate how the epileptic aura is associated with the health...... locus of control, anxiety, and depression. METHODS: Patients were included retrospectively, based on patient records from the epilepsy monitoring unit of the Rigshospitalet University Hospital. Participants were asked about the presence and nature of auras in a semistructured interview...... of others (e.g., doctors and parents). The Hospital Anxiety and Depression Scale was used to evaluate levels of anxiety and depression. RESULTS: Forty-nine patients, with mean age of 38years, participated in the study. Of these, 67% reported experiencing one or more auras; i.e., subjective warning signs...

  13. Relationship between primary restless legs syndrome and migraine with aura.

    Science.gov (United States)

    Acar, Bilgehan Atılgan; Acar, Türkan; Alagöz, Aybala Neslihan; Karacan, Alper; Varım, Ceyhun; Uyanık, Mehmet Şevki; Kaya, Tezcan; Akdemir, Ramazan

    2016-08-01

    In this study, the prevalence and characteristics of definite migraine in primary restless legs syndrome (pRLS) patients and matched control patients (CPs) were investigated. We evaluated 63 consecutive adult pRLS patients and 141 age- and sex-matched controls in this case-control study. The diagnosis of migraine and its subtypes were defined based on The International Classification of Headache Disorders-II. Only those with "definite" migraine were included in the study. The mean age of 63 adult pRLS patients (15 men and 48 women) who participated in the study was 49.4 years. A total of 27 patients (42.9%) had definite migraine. Of these migraineurs, seven (11.1%) were without aura and 20 (31.8%) were with aura. The mean age of the 141 matched CPs was 48.7 years. A total of 32 CPs (22.7%) experienced migraine. Among these 32 migraineurs, 28 (19.9%) were without aura and four (2.8%) were with aura. Migraine and migraine with aura were significantly more common in pRLS patients than in CPs. pRLS patients with migraine were more anxious and experienced a shorter duration of RLS symptoms than pRLS patients without migraine. Migraineurs in the pRLS group tended to have high scores for severity of migraine headache by Visual Analog Scale score and high levels of disability by Migraine Disability Assessment grading than those in the control group. pRLS patients showed a positive association with definite migraine headaches. In contrast to results highlighted in recent studies, we found a strong link between migraine with aura and pRLS. Copyright © 2016. Published by Elsevier Taiwan.

  14. Retraction: Plagiarism in the article Emphysematous cystitis and ...

    African Journals Online (AJOL)

    Retraction: Plagiarism in the article Emphysematous cystitis and emphysematous pyelitis: a clinically misleading association. Mustapha Ahsaini et al. The Pan African Medical Journal. 2013;16:18. (doi:10.11604/pamj.2013.16.18.2505)

  15. Dipyridamole may induce migraine in patients with migraine without aura

    DEFF Research Database (Denmark)

    Kruuse, C; Lassen, L H; Iversen, Helle Klingenberg

    2006-01-01

    Dipyridamole inhibits phosphodiesterase 5 (PDE5) and adenosine re-uptake. The most prominent side-effect is headache. We examined the migraine-generating effects of dipyridamole as well as the cerebral blood velocity response in a single-blind study, including 10 patients with migraine without aura...... repeatedly. Headache was induced in all migraine patients and in eight of 10 healthy subjects (P = 0.47) with no significant difference in headache intensity (P = 0.53). However, five patients but only one healthy subject experienced the symptoms of migraine without aura, according to ICHD-2 criteria, within...

  16. Provocation of migraine with aura using natural trigger factors

    DEFF Research Database (Denmark)

    Hougaard, Anders; Amin, Faisal; Hauge, Anne Werner

    2013-01-01

    It is well-known that migraine attacks can be precipitated by various stimuli. More than 50% of patients with migraine with aura (MA) know of at least one stimulus that always or often triggers their MA attacks. The objective of this study was to expose patients with MA to their self-reported tri......It is well-known that migraine attacks can be precipitated by various stimuli. More than 50% of patients with migraine with aura (MA) know of at least one stimulus that always or often triggers their MA attacks. The objective of this study was to expose patients with MA to their self...

  17. Potential role of lampalizumab for treatment of geographic atrophy [Retraction

    Directory of Open Access Journals (Sweden)

    Rhoades W

    2015-06-01

    Full Text Available Rhoades W, Dickson D, Do DV. Clinical Ophthalmology. 2015;9:1049–1056.The authors respectfully retract this review article. We realize that some of the results referenced in this manuscript are preliminary analyses and may not reflect the final data and conclusions of the clinical trials cited.Sincerely,Diana V Do, MDWilliam Rhoades, MDDrew Dickson, BAThis retraction relates to this paper.

  18. Retracted: Post-stroke epilepsy in Polish paediatric patients.

    Science.gov (United States)

    Kopyta, Ilona; Sarecka-Hujar, Beata

    2015-08-01

    The above article, published online on 5 October 2013 in Wiley Online Library Early View (http://onlinelibrary.wiley.com/), has been retracted by agreement between the authors, the journal Editor in Chief, Dr Peter Baxter, and John Wiley & Sons Ltd. The retraction has been agreed due to several errors in the statistics. These errors make interpretation of the data difficult and the validity of the conclusions questionable. © 2013 Mac Keith Press.

  19. Retractions in general and internal medicine in a high-profile scientific indexing database

    OpenAIRE

    Almeida,Renan Moritz Varnier Rodrigues de; Catelani,Fernanda; Fontes-Pereira,Aldo José; Gave,Nárrima de Souza

    2016-01-01

    CONTEXT AND OBJECTIVE: Increased frequency of retractions has recently been observed, and retractions are important events that deserve scientific investigation. This study aimed to characterize cases of retraction within general and internal medicine in a high-profile database, with interest in the country of origin of the article and the impact factor (IF) of the journal in which the retraction was made. DESIGN AND SETTING: This study consisted of reviewing retraction notes in the Thomso...

  20. Migraine headache is present in the aura phase: a prospective study.

    Science.gov (United States)

    Hansen, Jakob M; Lipton, Richard B; Dodick, David W; Silberstein, Stephen D; Saper, Joel R; Aurora, Sheena K; Goadsby, Peter J; Charles, Andrew

    2012-11-13

    Migraine aura is commonly considered to be a distinct phase of a migraine attack that precedes headache. The objective of the study was to examine a large number of prospectively recorded attacks of migraine with aura and determine the timing of headache and other migraine symptoms relative to aura. As part of a clinical trial we collected prospective data on the time course of headache and other symptoms relative to the aura. Patients (n = 267) were enrolled from 16 centers, and asked to keep a headache diary for 1 month (phase I). They were asked to record headache symptoms as soon as possible after aura began and always within 1 hour of aura onset. A total of 456 attacks were reported during phase I by 201 patients. These patients were then randomized and included in phase II, during which a total of 405 attacks were reported in 164 patients. In total, we present data from 861 attacks of migraine with aura from 201 patients. During the aura phase, the majority of attacks (73%) were associated with headache. Other migraine symptoms were also frequently reported during the aura: nausea (51%), photophobia (88%), and photophobia (73%). During the first 15 minutes within the onset of aura, 54% of patients reported headache fulfilling the criteria for migraine. Our results indicate that headaches as well as associated migraine symptoms are present early, during the aura phase of the migraine attack in the majority of patients.

  1. Repeat Stroke Associated with 'Migraine with Aura' and Middle ...

    African Journals Online (AJOL)

    We present a 21 year-old female, known migraineur, who presented with visual aura followed by throbbing left hemicranial headache, associated with sudden onset of weakness of the right side of the body and moderate to severe pains on the paretic limb (mixed lacuna stroke), three days after the onset of headache.

  2. Oak tree selection by nesting turkey vultures (Cathartes aura)

    Science.gov (United States)

    Gregory A. Giusti; R.J. Keiffer; Shane Feirer; R.F. Keiffer

    2015-01-01

    Turkey vultures (Cathartes aura) are a ubiquitous component of California’s oak woodland faunal assemblage. Though obvious, they are one of the least studied vertebrates found in our hardwood forests. This study attempts to define the role of oak trees as nesting sites for this large avian species. Verified nest trees are evaluated to determine...

  3. Aqua/Aura Inclination Adjust Maneuver Series Spring 2018 Planning

    Science.gov (United States)

    Trenholme, Elena; Boone, Spencer

    2017-01-01

    This will be presented at the International Earth Science Constellation Mission Operations Working Group meeting on December 6-8, 2017 to discuss the Aqua/Aura Spring 2018 Inclination Adjust Maneuver series planning. Presentation has been reviewed and approved by Eric Moyer, ESMO (Earth Science Mission Operations) Deputy Project Manager.

  4. High leptin levels are associated with migraine with aura.

    Science.gov (United States)

    Pisanu, Claudia; Preisig, Martin; Castelao, Enrique; Glaus, Jennifer; Cunningham, Janet L; Del Zompo, Maria; Merikangas, Kathleen R; Schiöth, Helgi B; Mwinyi, Jessica

    2017-04-01

    Background Migraine is a prevalent disorder characterised by recurrent headache attacks preceded or accompanied by aura in a subgroup of patients. Migraine often occurs together with major depressive disorder (MDD). Alterations of adipokine levels have been reported both in migraine and in MDD. In this cross-sectional study, we aimed to assess the associations between serum leptin and adiponectin levels and migraine or migraine subtypes. Analyses were adjusted for a lifetime history of MDD in order to investigate the association between adipokines and migraine under consideration of depression status. Methods We included 3025 participants from the CoLaus/PsyCoLaus study. The impact of leptin and adiponectin levels on a diagnosis of migraine was analysed by binary regression analyses, adjusting for variables known to influence adipokine levels. Subgroup analyses were conducted based on the presence of aura. Results Crude leptin levels were significantly higher in subjects with migraine than controls (Mann-Whitney U = 515,102, p = 6 × 10 -7 ). When performing adjusted analyses, leptin levels were found to be significantly higher in subjects with migraine (odds ratio = 1.22, p = 0.024) and migraine with aura (odds ratio = 1.34, p = 0.004). Conclusion High leptin levels might play a role in the pathogenesis of migraine and migraine with aura.

  5. Cryptocoryne aura (Araceae), a new species from West Kalimantan, Indonesia

    DEFF Research Database (Denmark)

    Wongso, Suwidji; Ipor, Isa B.; Tawan, Cheksum S.

    2016-01-01

    A new species, Cryptocoryne aura Wongso & Ipor, from West Kalimantan, Indonesia, is described and illustrated. It differs from other Cryptocoryne species primarily by having a transparent, ciliate membrane along the leaf margin and a short spathe with a yellow, forward-twisted limb. It has...

  6. Inducible nitric oxide synthase haplotype associated with migraine and aura.

    Science.gov (United States)

    de O S Mansur, Thiago; Gonçalves, Flavia M; Martins-Oliveira, Alisson; Speciali, Jose G; Dach, Fabiola; Lacchini, Riccardo; Tanus-Santos, Jose E

    2012-05-01

    Migraine is a complex neurological disorder with a clear neurogenic inflammatory component apparently including enhanced nitric oxide (NO) formation. Excessive NO amounts possibly contributing to migraine are derived from increased expression and activity of inducible NO synthase (iNOS). We tested the hypothesis that two functional, clinically relevant iNOS genetic polymorphisms (C(-1026)A-rs2779249 and G2087A-rs2297518) are associated with migraine with or without aura. We studied 142 healthy women without migraine (control group) and 200 women with migraine divided into two groups: 148 with migraine without aura (MWA) and 52 with aura (MA). Genotypes were determined by real-time polymerase chain reaction using the Taqman(®) allele discrimination assays. The PHASE 2.1 software was used to estimate the haplotypes. The A allele for the G2087A polymorphism was more commonly found in the MA group than in the MWA group (28 vs. 18%; P 0.05). The haplotype combining both A alleles for the two polymorphisms was more commonly found in the MA group than in the control group or in the MWA group (19 vs. 10 or 8%; P = 0.0245 or 0.0027, respectively). Our findings indicate that the G2087A and the C(-1026)A polymorphism in the iNOS gene affect the susceptibility to migraine with aura when their effects are combined within haplotypes, whereas the G2087A affects the susceptibility to aura in migraine patients. These finding may have therapeutic implications when examining the effects of selective iNOS inhibitors.

  7. Typology of Retractable Roof Structures in Stadiums and Sports Halls

    Directory of Open Access Journals (Sweden)

    Andrej Mahovič

    2015-10-01

    Full Text Available Retractable roof structures are one of the four fundamental systems (in addition to the playing area, stands and facade in a stadium and sports hall. The roof protects users against various weather conditions and creates optimum circumstances for carrying out different activities. Stadiums and sports halls with retractable roof structures can host a greater variety of activities, improve the quality of their implementation and the quality of visitors’ experience, and affect the perception and experience of people using or observing such buildings. A retractable roof structure allows for natural lighting and ventilation of the venue, gives optimal conditions for grass growth on the playing field, and reduces costs of use and maintenance of the building. Different typologies of movement of roof structures (frequency of opening and closing, design of the structure, and methods of movement are categorised in terms of their architectural and structural design. Application of different retractable roof systems worldwide is indicator of their effectiveness and efficiency, and is basis for use of movement also in other fundamental systems of stadiums and sports halls. Research and identification of characteristics of retractable roof structures lead to the design of new moving systems that can with the application of the moving principle change the purpose of movable elements or assume the characteristics of other fundamental systems.

  8. Exploring the characteristics, global distribution and reasons for retraction of published articles involving human research participants: a literature survey.

    Science.gov (United States)

    Li, Guowei; Kamel, Mariam; Jin, Yanling; Xu, Michael Kuan; Mbuagbaw, Lawrence; Samaan, Zainab; Levine, Mitchell Ah; Thabane, Lehana

    2018-01-01

    Article retraction is a measure taken by journals or authors where there is evidence of research misconduct or error, redundancy, plagiarism or unethical research. Recently, the retraction of scientific publications has been on the rise. In this survey, we aimed to describe the characteristics and distribution of retracted articles and the reasons for retractions. We searched retracted articles on the PubMed database and Retraction Watch website from 1980 to February 2016. The primary outcomes were the characteristics and distribution of retracted articles and the reasons for retractions. The secondary outcomes included how article retractions were handled by journals and how to improve the journal practices toward article retractions. We included 1,339 retracted articles. Most retracted articles had six authors or fewer. Article retraction was most common in the USA (26%), Japan (11%) and Germany (10%). The main reasons for article retraction were misconduct (51%, n = 685) and error (14%, n = 193). There were 66% (n = 889) of retracted articles having male senior or corresponding authors. Of the articles retracted after August 2010, 63% (n = 567) retractions were reported on Retraction Watch. Large discrepancies were observed in the ways that different journals handled article retractions. For instance, articles were completely withdrawn from some journals, while in others, articles were still available with no indication of retraction. Likewise, some retraction notices included a detailed account of the events that led to article retraction, while others only consisted of a statement indicating the article retraction. The characteristics, geographic distribution and reasons for retraction of published articles involving human research participants were examined in this survey. More efforts are needed to improve the consistency and transparency of journal practices toward article retractions.

  9. Increased interictal visual network connectivity in patients with migraine with aura.

    Science.gov (United States)

    Tedeschi, Gioacchino; Russo, Antonio; Conte, Francesca; Corbo, Daniele; Caiazzo, Giuseppina; Giordano, Alfonso; Conforti, Renata; Esposito, Fabrizio; Tessitore, Alessandro

    2016-02-01

    To evaluate the resting-state visual network functional connectivity in patients with migraine with aura and migraine without aura during the interictal period. Using resting-state functional magnetic resonance imaging, the resting-state visual network integrity was investigated in 20 patients with migraine with aura, 20 age- and sex-matched patients with migraine without aura and 20 healthy controls. Voxel-based morphometry and diffusion tensor imaging were used to assess whether between-groups differences in functional connectivity were dependent on structural or microstructural changes. Resting-state functional magnetic resonance imaging data showed that patients with migraine with aura, compared to both patients with migraine without aura and healthy controls, had a significant increased functional connectivity in the right lingual gyrus within the resting-state visual network (p aura exhibit an altered resting-state visual network connectivity. These results support the hypothesis of an extrastriate cortex involvement, centred in the lingual gyrus, a brain region related to mechanisms underlying the initiation and propagation of the migraine aura. This resting-state functional magnetic resonance imaging finding may represent a functional biomarker that could differentiate patients experiencing the aura phenomenon from patients with migraine without aura, even between migraine attacks. © International Headache Society 2015.

  10. Prospective testing of ICHD-3 beta diagnostic criteria for migraine with aura and migraine with typical aura in patients with transient ischemic attacks

    DEFF Research Database (Denmark)

    Lebedeva, Elena R; Gurary, Natalia M; Gilev, Denis V

    2018-01-01

    Introduction The International Classification of Headache Disorders 3rd edition beta (ICHD-3 beta) gave alternative diagnostic criteria for 1.2 migraine with aura (MA) and 1.2.1 migraine with typical aura (MTA) in the appendix. The latter were presumed to better differentiate transient ischemic...

  11. Characteristics of Retractions from Korean Medical Journals in the KoreaMed Database: A Bibliometric Analysis.

    Directory of Open Access Journals (Sweden)

    Sun Huh

    Full Text Available Flawed or misleading articles may be retracted because of either honest scientific errors or scientific misconduct. This study explored the characteristics of retractions in medical journals published in Korea through the KoreaMed database.We retrieved retraction articles indexed in the KoreaMed database from January 1990 to January 2016. Three authors each reviewed the details of the retractions including the reason for retraction, adherence to retraction guidelines, and appropriateness of retraction. Points of disagreement were reconciled by discussion among the three.Out of 217,839 articles in KoreaMed published from 1990 to January 2016, the publication type of 111 articles was retraction (0.051%. Of the 111 articles (addressing the retraction of 114 papers, 58.8% were issued by the authors, 17.5% were jointly issued (author, editor, and publisher, 15.8% came from editors, and 4.4% were dispatched by institutions; in 5.3% of the instances, the issuer was unstated. The reasons for retraction included duplicate publication (57.0%, plagiarism (8.8%, scientific error (4.4%, author dispute (3.5%, and other (5.3%; the reasons were unstated or unclear in 20.2%. The degree of adherence to COPE's retraction guidelines varied (79.8%-100%, and some retractions were inappropriate by COPE standards. These were categorized as follows: retraction of the first published article in the case of duplicate publication (69.2%, authorship dispute (15.4%, errata (7.7%, and other (7.7%.The major reason for retraction in Korean medical journals is duplicate publication. Some retractions resulted from overreaction by the editors. Therefore, editors of Korean medical journals should take careful note of the COPE retraction guidelines and should undergo training on appropriate retraction practices.

  12. Is Duane retraction syndrome part of the VACTERL association?

    Directory of Open Access Journals (Sweden)

    Akar S

    2013-03-01

    Full Text Available Serpil Akar,1 Birsen Gokyigit,1 Isilay Kavadarli,2 Ahmet Demirok11Pediatric Ophthalmology and Strabismus Department, Prof Dr N Resat Belger Beyoglu Education and Research Eye Hospital, Istanbul, 2Department of Ophthalmology, Gaziantep, Kilis State Hospital, Kilis, TurkeyAbstract: We report here a patient with type 1 Duane’s retraction syndrome and multiple congenital abnormalities as a result of the VACTERL association. The presented combination of Duane’s retraction syndrome and the VACTERL association has not been reported in the literature. The present case was instructive for reviewing the continuous spectrum of ocular anomalies that accompany the VACTERL association.Keywords: Duane’s retraction syndrome, VACTERL association, combination

  13. Retraction statement: Modern Concepts for Caries Tissue Removal.

    Science.gov (United States)

    2016-01-01

    "Modern Concepts for Caries Tissue Removal", by Falk Schwendicke The above article, published online on 15 February 2016 in Wiley Online Library (http://onlinelibrary.wiley.com/doi/10.llll/jerd.12201), has been retracted by agreement between the author, Dr. Falk Schwendicke, the journal Editor-in-Chief, Dr. Harald O. Heymann, Associate Editor, Dr. Edward Swift and Wiley Periodicals, Inc. The retraction has been agreed as the article was published in advance of other companion work which should have had precedence. The article pages have been replaced by the Retraction Statement and the article condensed accordingly. Schwendicke, F. Swift, EJ. Modern concepts for caries tissue removal. Dent J Esthet Rest 2016; 28:1; DOI: 10.1111/jerd.12201. © 2016 Wiley Periodicals, Inc.

  14. Distinctive anatomical and physiological features of migraine aura revealed by 18 years of recording.

    Science.gov (United States)

    Hansen, Jakob Møller; Baca, Serapio Michael; Vanvalkenburgh, Paul; Charles, Andrew

    2013-12-01

    The mechanisms underlying the initiation and propagation of the migraine aura, and the visual percept that is produces, remain uncertain. The objective of this study was to characterize and quantify a large number of visual auras recorded by a single individual over nearly two decades to gain insight into basic aura mechanisms. An individual made detailed drawings of his visual percept of migraine aura in real time during more than 1000 attacks of migraine aura without headache over 18 years. Drawings were made in a consistent fashion documenting the shape and location of the aura wavefront or scotoma in the visual field at one minute intervals. These drawings were digitized and the spatial and temporal features of auras were quantified and analysed. Consistent patterns of aura initiation, propagation and termination were observed in both right and left visual fields. Most aura attacks originated centrally (within 10° eccentricity), but there were also other distinct sites of initiation in the visual field. Auras beginning centrally preferentially propagated first through lower nasal field (69-77% of all auras) before travelling to upper and temporal fields, on both sides. Some auras propagated from peripheral to central regions of the visual field-these typically followed the reverse path of those travelling in the opposite direction. The mean velocity of the perceived visual phenomenon did not differ between attacks starting peripherally and centrally. The estimated speed of the underlying cortical event (2-3 mm/min) was in the same range as has been previously reported by others. Some auras had limited propagation and spontaneously 'aborted' after a few minutes, despite being initiated in similar locations to those that spread throughout the entire visual field. The visual percept of the aura changed corresponding with the presumed propagation from the V1 to the V2 region of the occipital cortex. In some cases the visual percept disappeared for several minutes

  15. Attic cholesteatoma with tiny retraction of pars flaccida.

    Science.gov (United States)

    Lee, Jun Ho; Hong, Seok Min; Kim, Chang Woo; Park, Yeo Hoon; Baek, So-Hye

    2015-04-01

    This clinical study was performed to analyze the characteristics of attic cholesteatoma occurring behind a tiny retraction of the pars flaccida, which was classified as Tos type I or II and had an intact pars tensa of the tympanic membrane. The clinical records of patients who underwent tympanomastoidectomy for attic cholesteatoma at a tertiary care referral center (Kangdong Sacred Heart Hospital of Seoul, Korea) between March 2004 and December 2012 were retrospectively reviewed. Eleven patients (five men and six women) who underwent tympanomastoidectomy between March 2004 and December 2012 for attic cholesteatoma occurring behind a tiny attic retraction were included. The mean age of patients was 41.1 years (range 20-58 years) and the mean duration of follow-up was 29.5 months (range 13-52 months). Every patient had a unilateral cholesteatoma, and the opposite side was normal except in one patient. Hearing loss was the most common symptom, followed by earfullness and otalgia. Five patients had type I attic retraction, and six patients had type II attic retraction. No patient had definite scutum erosion. Interestingly, during regular postoperative checkup, one patient was found incidentally for the opposite ear. Six patients had a cholesteatoma sac that was separated from the pars flaccida, whereas in five patients it was in contact with the pars flaccida but was easily separated. Six patients had a limited cholesteatoma within the epitympanum, and five patients had extension beyond the epitympanum. The average air-bone gap was 24.3±10.1dB before the operation and 14.2±6.6dB after the operation. Every patient had an intact tympanic membrane without retraction pocket postoperatively. There was no recurrence of cholesteatoma during follow-up. The rate of attic cholesteatomas occurring behind a tiny retraction of the pars flaccida was 7.7% (11 of 142 patients with attic cholesteatoma). Attic retractions must be followed closely using endoscopy, microscopy, and

  16. Approximate particle-like solutions for a nonlinear relativistic scalar complex field model in /3+1 dimensions

    Science.gov (United States)

    Maccari, Attilio

    2000-10-01

    A weakly nonlinear Lorentz invariant complex field model in 3+1 dimensions is studied by an asymptotic perturbation method, based on Fourier expansion and spatio-temporal rescaling. It is shown that a nonlinear system of partial differential equations describes oscillation amplitudes of Fourier modes. This system is C-integrable, i.e., can be linearized through a suitable transformation of the dependent and independent variables. We resolve the Cauchy problem and demonstrate that localized nondispersive waves (envelope solitons) with finite energy exist under appropriate initial conditions. These particle-like solutions propagate with the group velocity of their carrier wave. During a collision solitons maintain their shape, because the only change is a phase shift. Energy E and momentum p of solitons are identical to those of a relativistic particle. If the Planck constant is connected to the spatial dimension of the envelope soliton, then we obtain at the lowest order of approximation the quantum relations E=ℏ ω, λ= h/ p, where λ and ω are wavelength and frequency of the carrier wave. This work represents a possible way to achieve the Einstein-de Broglie soliton-particle concept.

  17. Three-dimensional structure and multistable optical switching of triple-twisted particle-like excitations in anisotropic fluids

    Science.gov (United States)

    Smalyukh, Ivan I.; Lansac, Yves; Clark, Noel A.; Trivedi, Rahul P.

    2010-02-01

    Control of structures in soft materials with long-range order forms the basis for applications such as displays, liquid-crystal biosensors, tunable lenses, distributed feedback lasers, muscle-like actuators and beam-steering devices. Bistable, tristable and multistable switching of well-defined structures of molecular alignment is of special interest for all of these applications. Here we describe the facile optical creation and multistable switching of localized configurations in the molecular orientation field of a chiral nematic anisotropic fluid. These localized chiro-elastic particle-like excitations-dubbed `triple-twist torons'-are generated by vortex laser beams and embed the localized three-dimensional (3D) twist into a uniform background. Confocal polarizing microscopy and computer simulations reveal their equilibrium internal structures, manifesting both skyrmion-like and Hopf fibration features. Robust generation of torons at predetermined locations combined with both optical and electrical reversible switching can lead to new ways of multistable structuring of complex photonic architectures in soft materials.

  18. Interference between source-free radiation and radiation from sources: Particle-like behavior for classical radiation

    Science.gov (United States)

    Boyer, Timothy H.

    2017-09-01

    A simple junior-level electrodynamics problem is used to illustrate the interference between a source-free standing plane wave and a wave generated by a pulse in a current sheet. Depending upon the relative phases between the standing wave and the current pulse and also upon the relative magnitudes, we can find quite different patterns of emitted energy and momentum. If the source gives a large radiation pulse so that the source-free plane wave can be neglected, then the radiation spreads out symmetrically on either side of the current sheet. However, if the radiation sheet gives a pulse with fields comparable to those of the standing wave, then we can find a single radiation pulse moving to the right while the current sheet recoils to the left or the situation with the directions reversed. The example is a crude illustration of particle-like behavior arising from conventional classical electromagnetic behavior in the presence of source-free radiation. The discussion makes contact with the ideas of photons in modern physics.

  19. Stomaplasty with pannicuectomy in an obese patient with stomal retraction: A case report

    Directory of Open Access Journals (Sweden)

    Eisaku Ito

    2016-01-01

    Conclusion: We report a case of an obese patient who underwent stomaplasty with pannicuectomy for stomal retraction. We believe that stomaplasty with pannicuectomy is a feasible option in obese patients with stomal retraction.

  20. The relation between migraine, typical migraine aura and "visual snow".

    Science.gov (United States)

    Schankin, Christoph J; Maniyar, Farooq H; Sprenger, Till; Chou, Denise E; Eller, Michael; Goadsby, Peter J

    2014-06-01

    To assess the relationship between the phenotype of the "visual snow" syndrome, comorbid migraine, and typical migraine aura on a clinical basis and using functional brain imaging. Patients with "visual snow" suffer from continuous TV-static-like tiny flickering dots in the entire visual field. Most patients describe a syndrome with additional visual symptoms of the following categories: palinopsia ("afterimages" and "trailing"), entopic phenomena arising from the optic apparatus itself (floaters, blue field entoptic phenomenon, photopsia, self-light of the eye), photophobia, nyctalopia (impaired night vision), as well as the non-visual symptom tinnitus. The high prevalence of migraine and typical migraine aura in this population has led to the assumption that "visual snow" is caused by persistent migraine aura. Due to the lack of objective measures, alternative diagnoses are malingering or a psychogenic disorder. (1) The prevalence of additional visual symptoms, tinnitus, and comorbid migraine as well as typical migraine aura was assessed in a prospective semi-structured telephone interview of patients with "visual snow." Correlations were calculated using standard statistics with P metabolism in a group of "visual snow" patients in comparison to healthy controls were identified using [(18) F]-2-fluoro-2-deoxy-D-glucose positron emission tomography and statistical parametric mapping (SPM8 with whole brain analysis; statistical significance was defined by P migraine and 37 had typical migraine aura. Having comorbid migraine was associated with an increased likelihood of having palinopsia (odds ratio [OR] 2.8; P = .04 for "afterimages" and OR 2.6; P = .01 for "trailing"), spontaneous photopsia (OR 2.9; P = .004), photophobia (OR 3.2; P = .005), nyctalopia (OR 2.7; P = .01), and tinnitus (OR 2.9; P = .006). Typical migraine aura was associated with an increased likelihood of spontaneous photopsia (OR 2.4; P = .04). (2) After adjusting

  1. Monitoring of the Canadian Oil Sands from the Aura Satellite

    Science.gov (United States)

    McLinden, C. A.; Shephard, M. W.; Fioletov, V.; Cady-Pereira, K. E.; Krotkov, N. A.; Boersma, K. F.; Li, C.; Luo, M.; Joiner, J.; Bhartia, P. K.

    2014-12-01

    Two instruments on-board the NASA Aura satellite, the Ozone Monitoring Instrument (OMI) and Tropospheric Emission Spectrometer (TES), have been used to monitor air pollution over the Canadian oil sands region. Between them they provide a unique perspective on the distributions, evolution, and sources of several key pollutants. This presentation will detail some highlights from these Aura-based oil sands studies: (i) the evolution of OMI-measured nitrogen dioxide and sulfur dioxide enhancements over the past decade, including comparisons with other nearby sources, (ii) two years of ammonia, carbon monoxide, methanol, and formic acid observations from TES special-observation transects, and (iii) preliminary insights into emissions derived from these observations.

  2. Heterogenous migraine aura symptoms correlate with visual cortex functional magnetic resonance imaging responses

    DEFF Research Database (Denmark)

    Arngrim, Nanna; Hougaard, Anders; Ahmadi, Khazar

    2017-01-01

    Objective: Migraine aura is sparsely studied due to the highly challenging task of capturing patients during aura. Cortical spreading depression (CSD) is likely the underlying phenomenon of aura. The possible correlation between the multifaceted phenomenology of aura symptoms and the effects of CSD...... on the brain has not been ascertained. Methods: Five migraine patients were studied during various forms of aura symptoms induced by hypoxia, sham hypoxia, or physical exercise with concurrent photostimulation. The blood oxygenation level–dependent (BOLD) functional magnetic resonance imaging (fMRI) signal...... corresponding bihemispherical changes in BOLD response. Interpretation: These findings suggest that different aura symptoms reflect different types of cerebral dysfunction, which correspond to specific changes in BOLD signal reactivity. Furthermore, we provide evidence of bilateral CSD recorded by fMRI during...

  3. The occurrence and characteristics of auras in a large epilepsy cohort

    DEFF Research Database (Denmark)

    Nakken, K O; Solaas, M H; Kjeldsen, M J

    2009-01-01

    Objectives - Despite several studies, estimates of the frequency with which auras occur in conjunction with epilepsy continue to be imprecise. The aim of this study was to assess the occurrence and characteristics of auras in a large population-based epilepsy cohort. Materials and methods...... - Subjects with verified epilepsy were recruited from population-based twin registries in the USA, Denmark and Norway. Using a structured interview in which a list of auras was provided, subjects were asked about the warning symptoms preceding their epileptic attacks. Results - 31% of the total sample (n...... = 1897) and 39% of those with active epilepsy (n = 765) had experienced an aura. Six percent reported more than one type. Non-specified auras were most frequently reported (35%), followed by somatosensory (11%) and vertiginous (11%). While the majority of those reporting auras (59%) had focal epilepsies...

  4. Psychotic aura symptoms in familial hemiplegic migraine type 2 (ATP1A2).

    Science.gov (United States)

    Barros, José; Mendes, Alexandre; Matos, Ilda; Pereira-Monteiro, José

    2012-10-01

    Neuropsychological symptoms are rare in familial hemiplegic migraine (FHM). There are no reports of psychotic symptoms in FHM type 2 (ATP1A2). We examined a family with a FHM phenotype due to a M731T mutation in ATP1A2. A 10-year follow-up allowed us to observe complex auras, including psychotic symptoms in two siblings. Male, 48 years old, with an aura that included complex illusions with a feeling of time travelling, coincident with other aura features. The aura was regarded as mystical by the patient. Female, 38 years old, with a complex migraine aura, during which she believed she had the ability to time travel and was being followed by lobbyists who wanted to steal this ability from her. FHM type 2 must be included in the list of differential diagnoses of acute psychosis in patients with a previous history of migraine aura.

  5. Sensory migraine aura is not associated with structural grey matter abnormalities

    DEFF Research Database (Denmark)

    Hougaard, Anders; Amin, Faisal Mohammad; Arngrim, Nanna

    2016-01-01

    in a large group of MA patients with and without sensory aura (i.e. gradually developing, transient unilateral sensory disturbances). We included 60 patients suffering from migraine with typical visual aura and 60 individually age and sex-matched controls. Twenty-nine of the patients additionally experienced....... These differences were not correlated to the clinical characteristics. Our results suggest that sensory migraine aura is not associated with altered grey matter structure and that patients with visual aura have normal cortical structure of areas involved in visual processing. The observed decreased grey matter...... sensory aura regularly. We analysed high-resolution structural MR images using two complimentary approaches and compared patients with and without sensory aura. Patients were also compared to controls. We found no differences of grey matter density or cortical thickness between patients with and without...

  6. Aqua/Aura Updated Inclination Adjust Maneuver Performance Prediction Model

    Science.gov (United States)

    Boone, Spencer

    2017-01-01

    This presentation will discuss the updated Inclination Adjust Maneuver (IAM) performance prediction model that was developed for Aqua and Aura following the 2017 IAM series. This updated model uses statistical regression methods to identify potential long-term trends in maneuver parameters, yielding improved predictions when re-planning past maneuvers. The presentation has been reviewed and approved by Eric Moyer, ESMO Deputy Project Manager.

  7. Pediatric extratemporal epilepsy presenting with a complex auditory aura.

    Science.gov (United States)

    Clarke, Dave F; Boop, Frederick A; McGregor, Amy L; Perkins, F Frederick; Brewer, Vickie R; Wheless, James W

    2008-06-01

    Ear plugging (placing fingers in or covering the ears) is a clinical seizure semiology that has been described as a response to an unformed, auditory hallucination localized to the superior temporal neocortex. The localizing value of ear plugging in more complex auditory hallucinations may have more involved circuitry. We report on one child, whose aura was a more complex auditory phenomenon, consisting of a door opening and closing, getting louder as the ictus persisted. This child presented, at four years of age, with brief episodes of ear plugging followed by an acute emotional change that persisted until surgical resection of a left mesial frontal lesion at 11 years of age. Scalp video-EEG, magnetic resource imaging, magnetoencephalography, and invasive video-EEG monitoring were carried out. The scalp EEG changes always started after clinical onset. These were not localizing, and encompassed a wide field over the bi-frontal head regions, the left side predominant over the right. Intracranial video-EEG monitoring with subdural electrodes over both frontal and temporal regions localized the seizure-onset to the left mesial frontal lesion. The patient has remained seizure-free since the resection on June 28, 2006, approximately one and a half years ago. Ear plugging in response to simple auditory auras localize to the superior temporal gyrus. If the patient has more complex, formed auditory auras, not only may the secondary auditory areas in the temporal lobe be involved, but one has to entertain the possibility of ictal-onset from the frontal cortex.

  8. EOS-Aura's Ozone Monitoring Instrument (OMI): Validation Requirements

    Science.gov (United States)

    Brinksma, E. J.; McPeters, R.; deHaan, J. F.; Levelt, P. F.; Hilsenrath, E.; Bhartia, P. K.

    2003-01-01

    OMI is an advanced hyperspectral instrument that measures backscattered radiation in the UV and visible. It will be flown as part of the EOS Aura mission and provide data on atmospheric chemistry that is highly synergistic with other Aura instruments HIRDLS, MLS, and TES. OMI is designed to measure total ozone, aerosols, cloud information, and UV irradiances, continuing the TOMS series of global mapped products but with higher spatial resolution. In addition its hyperspectral capability enables measurements of trace gases such as SO2, NO2, HCHO, BrO, and OClO. A plan for validation of the various OM1 products is now being formulated. Validation of the total column and UVB products will rely heavily on existing networks of instruments, like NDSC. NASA and its European partners are planning aircraft missions for the validation of Aura instruments. New instruments and techniques (DOAS systems for example) will need to be developed, both ground and aircraft based. Lidar systems are needed for validation of the vertical distributions of ozone, aerosols, NO2 and possibly SO2. The validation emphasis will be on the retrieval of these products under polluted conditions. This is challenging because they often depend on the tropospheric profiles of the product in question, and because of large spatial variations in the troposphere. Most existing ground stations are located in, and equipped for, pristine environments. This is also true for almost all NDSC stations. OMI validation will need ground based sites in polluted environments and specially developed instruments, complementing the existing instrumentation.

  9. Duane retraction syndrome type 1 with Usher syndrome type 2: an unreported association.

    Science.gov (United States)

    Khurana, Bhawna Piplani; Khurana, Aruj Kumar; Grover, Sumit

    2015-05-07

    Duane retraction syndrome is characterized by globe retraction and palpebral fissure narrowing on adduction, with restriction of abduction, adduction, or both. Usher syndrome type 2 consists of congenital bilateral sensorineural hearing loss and retinitis pigmentosa. The authors present a case with a yet unreported association between Duane retraction syndrome type 1 and Usher syndrome type 2. Copyright 2015, SLACK Incorporated.

  10. Plagiarism Allegations Account for Most Retractions in Major Latin American/Caribbean Databases.

    Science.gov (United States)

    Almeida, Renan Moritz V R; de Albuquerque Rocha, Karina; Catelani, Fernanda; Fontes-Pereira, Aldo José; Vasconcelos, Sonia M R

    2016-10-01

    This study focuses on retraction notices from two major Latin American/Caribbean indexing databases: SciELO and LILACS. SciELO includes open scientific journals published mostly in Latin America/the Caribbean, from which 10 % are also indexed by Thomson Reuters Web of Knowledge Journal of Citation Reports (JCR). LILACS has a similar geographical coverage and includes dissertations and conference/symposia proceedings, but it is limited to publications in the health sciences. A search for retraction notices was performed in these two databases using the keywords "retracted", "retraction" "withdrawal", "withdrawn", "removed" and "redress". Documents were manually checked to identify those that actually referred to retractions, which were then analyzed and categorized according to the reasons alleged in the notices. Dates of publication/retraction and time to retraction were also recorded. Searching procedures were performed between June and December 2014. Thirty-one retraction notices were identified, fifteen of which were in JCR-indexed journals. "Plagiarism" was alleged in six retractions of this group. Among the non-JCR journals, retraction reasons were alleged in fourteen cases, twelve of which were attributed to "plagiarism". The proportion of retracted articles for the SciELO database was approximately 0.005 %. The reasons alleged in retraction notices may be used as signposts to inform discussions in Latin America on plagiarism and research integrity. At the international level, these results suggest that the correction of the literature is becoming global and is not limited to mainstream international publications.

  11. Greater occipital nerve block for the acute treatment of prolonged or persistent migraine aura.

    Science.gov (United States)

    Cuadrado, María L; Aledo-Serrano, Ángel; López-Ruiz, Pedro; Gutiérrez-Viedma, Álvaro; Fernández, Cristina; Orviz, Aida; Arias, José A

    2017-07-01

    Background Presently, there is no evidence to guide the acute treatment of migraine aura. We aimed to describe the effect of greater occipital nerve (GON) anaesthetic block as a symptomatic treatment for long-lasting (prolonged or persistent) migraine aura. Methods Patients who presented with migraine aura lasting > 2 hours were consecutively recruited during one year at the Headache Unit and the Emergency Department of a tertiary hospital. All patients underwent a bilateral GON block with bupivacaine 0.5%. Patients were followed up for 24 hours. Results A total of 22 auras were treated in 18 patients. Auras consisted of visual ( n = 13), visual and sensory ( n = 4) or sensory symptoms alone ( n = 5). Eleven episodes met diagnostic criteria for persistent aura (>1 week) without infarction. The response was complete without early recurrence in 11 cases (50%), complete with recurrence in auras lasting auras (72.7% vs. 27.3%; p = 0.033). Conclusions GON block could be an effective symptomatic treatment for prolonged or persistent migraine aura. Randomised controlled trials are still required to confirm these results.

  12. Probing the Forces of Germband Retraction with Laser-Microsurgery

    Science.gov (United States)

    Lynch, Holley; Rosenthal, Brett; Kim, Elliott; Gish, Robert; Hutson, M. Shane

    2010-03-01

    Germband retraction is a stage of fruit fly embryogenesis that involves the coordinated movement of two tissues: the germband (GB), which uncurls while its cells elongate, and the amnioserosa (AS), whose cells shorten their long axis. To determine the mechanical causes of GB retraction, we conducted three series of laser ablations. First, we made linear incisions in the GB. We find an anisotropy in the maximum wound expansion consistent with a tensile force generated by the AS and applied to segments located around the curve of the GB. Second, we separated a patch of cells from the rest of the GB. These isolated cells do not continue to elongate, but instead round up. Even so, they often continue moving in the same direction. Third, we ablated part of one side of the saddle-shaped AS. Cuts destroying the AS cells closest to the curve of the GB halt GB retraction. Other AS cuts slow it. Our results indicate that the AS plays a mechanical role in GB retraction by applying tensile force to the curve of the GB.

  13. Alkaline phosphatase activity in gingival crevicular fluid during canine retraction.

    Science.gov (United States)

    Batra, P; Kharbanda, Op; Duggal, R; Singh, N; Parkash, H

    2006-02-01

    The aim of the study was to investigate alkaline phosphatase activity in the gingival crevicular fluid (GCF) during orthodontic tooth movement in humans. Postgraduate orthodontic clinic. Ten female patients requiring all first premolar extractions were selected and treated with standard edgewise mechanotherapy. Canine retraction was done using 100 g sentalloy springs. Maxillary canine on one side acted as experimental site while the contralateral canine acted as control. Gingival crevicular fluid was collected from mesial and distal of canines before initiation of canine retraction (baseline), immediately after initiation of retraction, and on 1st, 7th, 14th and 21st day and the alkaline phosphatase activity was estimated. The results show significant (p alkaline phosphatase activity on the 7th, 14th and 21st day on both mesial and distal aspects of the compared experimental and control sides. The peak in enzyme activity occurred on the 14th day of initiation of retraction followed by a significant fall in activity especially on the mesial aspect. The study showed that alkaline phosphatase activity could be successfully estimated in the GCF using calorimetric estimation assay kits. The enzyme activity showed variation according to the amount of tooth movement.

  14. Composition, Enzymes Analysis and Retraction Time of Columellar ...

    African Journals Online (AJOL)

    Composition, Enzymes Analysis and Retraction Time of Columellar Muscles of Giant African Land Snail ( Archachatina marginata ) in Response to External ... The columellar muscle of A. achatina had the highest concentration of glucose and lipids(8.3mg/dl and 46.9mg/dl respectively) while A. marginata had the least.

  15. Ergodic Retractions for Families of Asymptotically Nonexpansive Mappings

    Directory of Open Access Journals (Sweden)

    Saeidi Shahram

    2010-01-01

    Full Text Available We prove some theorems for the existence of ergodic retractions onto the set of common fixed points of a family of asymptotically nonexpansive mappings. Our results extend corresponding results of Benavides and Ramírez (2001, and Li and Sims (2002.

  16. Promoting Ethics and Integrity in Management Academic Research: Retraction Initiative.

    Science.gov (United States)

    Ayodele, Freida Ozavize; Yao, Liu; Haron, Hasnah

    2018-02-13

    In the management academic research, academic advancement, job security, and the securing of research funds at one's university are judged mainly by one's output of publications in high impact journals. With bogus resumes filled with published journal articles, universities and other allied institutions are keen to recruit or sustain the appointment of such academics. This often places undue pressure on aspiring academics and on those already recruited to engage in research misconduct which often leads to research integrity. This structured review focuses on the ethics and integrity of management research through an analysis of retracted articles published from 2005 to 2016. The study employs a structured literature review methodology whereby retracted articles published between 2005 and 2016 in the field of management science were found using Crossref and Google Scholar. The searched articles were then streamlined by selecting articles based on their relevance and content in accordance with the inclusion criteria. Based on the analysed retracted articles, the study shows evidence of ethical misconduct among researchers of management science. Such misconduct includes data falsification, the duplication of submitted articles, plagiarism, data irregularity and incomplete citation practices. Interestingly, the analysed results indicate that the field of knowledge management includes the highest number of retracted articles, with plagiarism constituting the most significant ethical issue. Furthermore, the findings of this study show that ethical misconduct is not restricted to a particular geographic location; it occurs in numerous countries. In turn, avenues of further study on research misconduct in management research are proposed.

  17. 'Visual snow' - a disorder distinct from persistent migraine aura.

    Science.gov (United States)

    Schankin, Christoph J; Maniyar, Farooq H; Digre, Kathleen B; Goadsby, Peter J

    2014-05-01

    Patients with 'visual snow' report continuous tiny dots in the entire visual field similar to the noise of an analogue television. As they frequently have migraine as a comorbidity with ophthalmological, neurological and radiological studies being normal, they are offered various diagnoses, including persistent migraine aura, post-hallucinogen flashback, or psychogenic disorder. Our aim was to study patients with 'visual snow' to characterize the phenotype. A three-step approach was followed: (i) a chart review of patients referred to us identified 22 patients with 'visual snow'. Fifteen had additional visual symptoms, and 20 patients had comorbid migraine, five with aura; (ii) to identify systematically additional visual symptoms, an internet survey (n = 275) of self-assessed 'visual snow' subjects done by Eye On Vision Foundation was analysed. In two random samples from 235 complete data sets, the same eight additional visual symptoms were present in >33% of patients: palinopsia (trailing and afterimages), entoptic phenomena (floaters, blue field entoptic phenomenon, spontaneous photopsia, self-light of the eye), photophobia, and nyctalopia (impaired night vision); and (iii) a prospective semi-structured telephone interview in a further 142 patients identified 78 (41 female) with confirmed 'visual snow' and normal ophthalmological exams. Of these, 72 had at least three of the additional visual symptoms from step (ii). One-quarter of patients had 'visual snow' as long as they could remember, whereas for the others the mean age of onset was 21 ± 9 years. Thirty-two patients had constant visual symptoms, whereas the remainder experienced either progressive or stepwise worsening. Headache was the most frequent symptom associated with the beginning or a worsening of the visual disturbance (36%), whereas migraine aura (seven patients) and consumption of illicit drugs (five, no hallucinogens) were rare. Migraine (59%), migraine with aura (27%), anxiety and depression

  18. Retractable Pin Tools for the Friction Stir Welding Process

    Science.gov (United States)

    1998-01-01

    Two companies have successfully commercialized a specialized welding tool developed at the Marshall Space Flight Center (MSFC). Friction stir welding uses the high rotational speed of a tool and the resulting frictional heat created from contact to crush, 'stir' together, and forge a bond between two metal alloys. It has had a major drawback, reliance on a single-piece pin tool. The pin is slowly plunged into the joint between two materials to be welded and rotated as high speed. At the end of the weld, the single-piece pin tool is retracted and leaves a 'keyhole,' something which is unacceptable when welding cylindrical objects such as drums, pipes and storage tanks. Another drawback is the requirement for different-length pin tools when welding materials of varying thickness. An engineer at the MSFC helped design an automatic retractable pin tool that uses a computer-controlled motor to automatically retract the pin into the shoulder of the tool at the end of the weld, preventing keyholes. This design allows the pin angle and length to be adjusted for changes in material thickness and results in a smooth hole closure at the end of the weld. Benefits of friction stir welding, using the MSFC retractable pin tool technology, include the following: The ability to weld a wide range of alloys, including previously unweldable and composite materials; provision of twice the fatigue resistance of fusion welds and no keyholes; minimization of material distortion; no creation of hazards such as welding fumes, radiation, high voltage, liquid metals, or arcing; automatic retraction of the pin at the end of the weld; and maintaining full penetration of the pin.

  19. Headache as an Aura of Epilepsy: Video-EEG Monitoring Study.

    Science.gov (United States)

    Kim, Dong Wook; Sunwoo, Jun-Sang; Lee, Sang Kun

    2016-04-01

    Headache can be associated with epilepsy as a pre-ictal, ictal, or post-ictal phenomenon; however, studies of patients with headache as an epileptic aura are scarce. We performed the present study to investigate the incidence and characteristics of headache as an epileptic aura, via confirmation of electroencephalography (EEG) changes by video-EEG monitoring. Data of aura and clinical seizure episodes of 831 consecutive patients who undertook video-EEG monitoring were analyzed retrospectively. For patients who had headache as an aura, information on the detailed features of headache was acquired, including location, nature, duration, and the presence of accompanying symptoms. Video-recorded clinical seizures, EEG findings, and neuroimaging data were used to determine the ictal onset areas in the patients. Six out of 831 (0.7%) patients experienced headache as aura (age range, 25-52 years), all of whom had partial seizures. The incidence of pre-ictal headache was 6.3% (25/831), and post-ictal headache was 30.9% (257/831). In patients with headache as aura, five patients described headache as the most frequent aura, and headache was the second most frequent aura in one patient. The characteristics of headache were hemicrania epileptica in two patients, tension-type headache in another two patients, and migraine-like headache in the remaining two patients. No patient met the diagnostic criteria of ictal epileptic headache or migraine aura-triggered seizure. Our study showed that headache as an aura is uncommon in adult patients with epilepsy, and that headache can present as diverse features, including hemicrania epileptica, tension-type headache, and migraine-like headache. Further studies are necessary to characterize the features of headache as an epileptic aura in adult patients with epilepsy. © 2016 American Headache Society.

  20. Sensory migraine aura is not associated with structural grey matter abnormalities.

    Science.gov (United States)

    Hougaard, Anders; Amin, Faisal Mohammad; Arngrim, Nanna; Vlachou, Maria; Larsen, Vibeke Andrée; Larsson, Henrik B W; Ashina, Messoud

    2016-01-01

    Migraine with aura (MA) is characterized by cortical dysfunction. Frequent aura attacks may alter cerebral cortical structure in patients, or structural grey matter abnormalities may predispose MA patients to aura attacks. In the present study we aimed to investigate cerebral grey matter structure in a large group of MA patients with and without sensory aura (i.e. gradually developing, transient unilateral sensory disturbances). We included 60 patients suffering from migraine with typical visual aura and 60 individually age and sex-matched controls. Twenty-nine of the patients additionally experienced sensory aura regularly. We analysed high-resolution structural MR images using two complimentary approaches and compared patients with and without sensory aura. Patients were also compared to controls. We found no differences of grey matter density or cortical thickness between patients with and without sensory aura and no differences for the cortical visual areas between patients and controls. The somatosensory cortex was thinner in patients (1.92 mm vs. 1.96 mm, P = 0.043) and the anterior cingulate cortex of patients had a decreased grey matter density (P = 0.039) compared to controls. These differences were not correlated to the clinical characteristics. Our results suggest that sensory migraine aura is not associated with altered grey matter structure and that patients with visual aura have normal cortical structure of areas involved in visual processing. The observed decreased grey matter volume of the cingulate gyrus in patients compared to controls have previously been reported in migraine with and without aura, but also in a wide range of other neurologic and psychiatric disorders. Most likely, this finding reflects general bias between patients and healthy controls.

  1. Sensory migraine aura is not associated with structural grey matter abnormalities

    Directory of Open Access Journals (Sweden)

    Anders Hougaard

    2016-01-01

    Full Text Available Migraine with aura (MA is characterized by cortical dysfunction. Frequent aura attacks may alter cerebral cortical structure in patients, or structural grey matter abnormalities may predispose MA patients to aura attacks. In the present study we aimed to investigate cerebral grey matter structure in a large group of MA patients with and without sensory aura (i.e. gradually developing, transient unilateral sensory disturbances. We included 60 patients suffering from migraine with typical visual aura and 60 individually age and sex-matched controls. Twenty-nine of the patients additionally experienced sensory aura regularly. We analysed high-resolution structural MR images using two complimentary approaches and compared patients with and without sensory aura. Patients were also compared to controls. We found no differences of grey matter density or cortical thickness between patients with and without sensory aura and no differences for the cortical visual areas between patients and controls. The somatosensory cortex was thinner in patients (1.92 mm vs. 1.96 mm, P = 0.043 and the anterior cingulate cortex of patients had a decreased grey matter density (P = 0.039 compared to controls. These differences were not correlated to the clinical characteristics. Our results suggest that sensory migraine aura is not associated with altered grey matter structure and that patients with visual aura have normal cortical structure of areas involved in visual processing. The observed decreased grey matter volume of the cingulate gyrus in patients compared to controls have previously been reported in migraine with and without aura, but also in a wide range of other neurologic and psychiatric disorders. Most likely, this finding reflects general bias between patients and healthy controls.

  2. OMI/Aura Ozone (O3) Total Column 1-Orbit L2 Swath 13x24 km V003

    Data.gov (United States)

    National Aeronautics and Space Administration — The OMI/Aura Level-2 Total Column Ozone Data Product OMTO3 (Version 003) is made available (http://disc.gsfc.nasa.gov/Aura/OMI/omto3_v003.shtml) from the NASA...

  3. OMI/Aura Ozone (O3) DOAS Total Column 1-Orbit L2 Swath 13x24 km V003

    Data.gov (United States)

    National Aeronautics and Space Administration — The second release of Version 003 OMI/Aura Level-2 Total Column Ozone Data Product OMDOAO3 is now available ( http://disc.gsfc.nasa.gov/Aura/OMI/omdoao3_v003.shtml )...

  4. OMI/Aura Formaldehyde (HCHO) Total Column Global 0.25deg Lat/Lon Grid V003

    Data.gov (United States)

    National Aeronautics and Space Administration — The Version-3 Aura-OMI Formaldehyde Product OMHCHOG is now available (http://disc.gsfc.nasa.gov/Aura/OMI/omhchog_v003.shtml) from the NASA Goddard Earth Sciences...

  5. OMI/Aura Zoom-in Ground Pixel Corners 1-Orbit L2 Swath 13x12km V003

    Data.gov (United States)

    National Aeronautics and Space Administration — The Version-3 Aura/OMI Zoom-in Pixel Corner Coordinates and Pixel Size Product, OMPIXCORZ, is available (http://disc.gsfc.nasa.gov/Aura/OMI/ompixcorz_v003.shtml)...

  6. OMI/Aura Formaldehyde (HCHO) Total Column 1-orbit L2 Swath 13x24 km V003

    Data.gov (United States)

    National Aeronautics and Space Administration — The Version-3 Formaldehyde Product OMHCHO from the Aura-OMI is now available (http://disc.gsfc.nasa.gov/Aura/OMI/omhcho_v003.shtml) from the NASA Goddard Earth...

  7. 75 FR 13806 - Culturally Significant Objects Imported for Exhibition Determinations: “Loan From the Aura...

    Science.gov (United States)

    2010-03-23

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Loan From the Aura Collection of a... hereby determine that the object to be included in the exhibition ``Loan from the Aura Collection of a...

  8. Cerebral oxygen extraction, oxygen consumption, and regional cerebral blood flow during the aura phase of migraine

    DEFF Research Database (Denmark)

    Friberg, L; Olesen, Jes; Lassen, N A

    1994-01-01

    The aura phase of migraine is associated with focal blood flow changes, but it has been largely unknown whether these changes are correlated to changes in the cerebral metabolism.......The aura phase of migraine is associated with focal blood flow changes, but it has been largely unknown whether these changes are correlated to changes in the cerebral metabolism....

  9. What's NEW at the GES DISC: Evolution of Data Management and Services for Aura Mission and Beyond

    Science.gov (United States)

    Wei, Jennifer

    2016-01-01

    GES DISC world. Aura data usage and trend. Aura data users requests. GES DISC update (before/after); New Access method (ftp to http) with Earthdata Login System, New Website (DISC/Mirador to New Interface), New Giovanni (Giovanni to Now Federated). GES DISC support beyond Aura Mission; Multi-sensor coincident data subsets, Level 2 support (Sub-setter, Visualization), Data List.

  10. Site Protection Efforts at the AURA Observatory in Chile

    Science.gov (United States)

    Smith, R. Chris; Smith, Malcolm G.; Sanhueza, Pedro

    2015-08-01

    The AURA Observatory (AURA-O) was the first of the major international observatories to be established in northern Chile to exploit the optimal astronomical conditions available there. The site was originally established in 1962 to host the Cerro Tololo Inter-American Observatory (CTIO). It now hosts more than 20 operational telescopes, including some of the leading U.S. and international astronomical facilities in the southern hemisphere, such as the Blanco 4m telescope on Cerro Tololo and the Gemini-South and SOAR telescopes on Cerro Pachón. Construction of the next generation facility, the Large Synoptic Survey Telescope (LSST), has recently begun on Cerro Pachón, while additional smaller telescopes continue to be added to the complement on Cerro Tololo.While the site has become a major platform for international astronomical facilities over the last 50 years, development in the region has led to an ever-increasing threat of light pollution around the site. AURA-O has worked closely with local, regional, and national authorities and institutions (in particular with the Chilean Ministries of Environment and Foreign Relations) in an effort to protect the site so that future generations of telescopes, as well as future generations of Chileans, can benefit from the dark skies in the region. We will summarize our efforts over the past 15 years to highlight the importance of dark sky protection through education and public outreach as well as through more recent promotion of IDA certifications in the region and support for the World Heritage initiatives described by others in this conference.

  11. Using NASA's Aura Satellite Data for Inquiry Based Classroom Instruction

    Science.gov (United States)

    Carter, B. L.; Stockman, S.; Bojkov, B.

    2007-12-01

    NASA's Earth Observing Satellite Aura was launched in 2004, and since that time has been collecting a wealth of data that contributes to scientists' understanding of the complexity of air quality issues. The Aura spacecraft monitors five of the six EPA criteria pollutants (NO2, SO2, O3, aerosols, and CO). Data from one of the criteria pollutants, NO2, are now available in a format useful to educators and students. The data by itself is not enough for students to engage in the scientific reasoning process. Thus, inquiry-driven supporting material in the form of lessons, project based learning scenarios, and curricular support for online data have all been adapted as part of the scaffolding necessary to help students gain an understanding of issues pertaining to air quality. These materials are delivered online which makes them readily accessible to the education community. Currently, NO2 data are available for manipulation using tools such as GoogleEarth and MY NASA DATA (http://mynasadata.larc.nasa.gov). These tools are used to investigate common relationships between spatial distribution and variability of NO2 concentrations. Through guided investigations in the Earth Exploration Toolbook (http://serc.carleton.edu/eet/index.html) or MY NASA DATA, students gain an understanding of NO2 variability. Students are then asked to extrapolate their knowledge and understanding to investigate other air quality issues relating to NO2. Within the coming year, the lessons built around Aura data will be introduced in professional development workshops. Feedback from those attending the professional development workshops about how the data and lessons are used in the classroom will be used to help shape future lesson development on new data. Subsequent data on criteria pollutants of SO2, aerosols, and O3 will soon be made available in a similar format to the education community, helping to further student understanding of the complex nature of air quality issues.

  12. Aura fractal, fins da arte e capitalismo primitivista

    Directory of Open Access Journals (Sweden)

    Leonardo Carvalho Bertolossi

    2017-10-01

    Full Text Available Objetiva-se refletir sobre as relações entre as artes visuais e a antropologia a partir do texto seminal de Walter Benjamin sobre a aura para pensar sobre as finalidades e os fins da metafísica da arte no Ocidente diante dos diagnósticos de fim de mundo/fim da história da arte, e da vitória do espetáculo e da indústria cultural no capitalismo contemporâneo. O artigo apresenta alguns dos sentidos da arte no mundo ocidental e em especial no romantismo, avança sobre a crise e o fim dos modelos estruturais e cognitivos do pensamento artístico moderno, destaca o interesse pela política e pela vida, e se indaga sobre a retomada do primitivismo nas artes visuais e na antropologia contemporânea como redenção e renovação das mortes anunciadas. ABSTRACT The objective is to reflect on the relations between the visual arts and anthropology from Walter Benjamin's seminal text on the aura to think about the purposes and ends of the metaphysics of art in the West in the face of end-of-world/end-of-art history, and the victory of spectacle and cultural industry in contemporary capitalism. The article presents some of the meanings of art in the Western world and especially in Romanticism, advances on the crisis and the end of the structural and cognitive models of modern artistic thought, highlights the interest in politics and life, and inquires about the resumption of Primitivism in the visual arts and contemporary anthropology as redemption and renewal of the announced deaths. KEYWORDS Anthropology of art, aura, soul, thanatology, primitivism

  13. History of migraine with aura and cortical spreading depression from 1941 and onwards

    DEFF Research Database (Denmark)

    Tfelt-Hansen, P C

    2010-01-01

    Several personal descriptions of migraine with aura from 1870 onwards reported a slow, gradual progression of symptoms. Lashley in 1941 meticulously chartered his own auras and concluded that the symptomatology reflected a cortical process progressing with a speed of 3 mm/min across the primary...... visual cortex. Leão described cortical spreading depression (CSD) in rabbits in 1944 and noticed its similarity to the migraine aura. Despite these scattered pieces of evidence, the prevailing theory was that the migraine aura was caused by a vasospasm and cortical ischaemia. The advent of a technique...... for measurements of regional cerebral blood flow (rCBF) in 1974 made it possible to detect spreading oligaemia during migraine aura. Between 1981 and 1990 a series of studies of rCBF during migraine attacks showed reduced brain blood flow posteriorly spreading slowly and contiguously anteriorly and crossing...

  14. [Aura-related symptoms associated with cluster headache: outcomes of a LUCA substudy].

    Science.gov (United States)

    Wilbrink, L A; Cheung, Carlo; Weller, Claudia M; Ferrari, Michel D; Haan, Joost

    2013-01-01

    To describe the prevalence of aura in a Dutch cluster headache (CH) population. Cross-sectional, epidemiological study. As part of a large-scale study into headaches conducted in Leiden (the Netherlands), patients experiencing headaches were identified by means of questionnaires on a headache website. One group of patients with CH was approached by telephone and an interview on aura-related symptoms was performed by means of a standardized questionnaire. The presence of migraine co-morbidity was also investigated. Of the interviewed CH patients, 22 out of 244 (9.0%) had aura-related symptoms preceding a CH attack, which were predominantly visual in nature. The majority (72.7%) of these patients did not have migraine co-morbidity. Aura-related symptoms can occur in CH without migraine co-morbidity. In clinical practice, it should be taken into account that the presence of an aura does not always indicate migraine.

  15. Increased brainstem perfusion, but no blood-brain barrier disruption, during attacks of migraine with aura

    DEFF Research Database (Denmark)

    Hougaard, Anders; Amin, Faisal M; Christensen, Casper E

    2017-01-01

    See Moskowitz (doi:10.1093/brain/awx099) for a scientific commentary on this article.The migraine aura is characterized by transient focal cortical disturbances causing dramatic neurological symptoms that are usually followed by migraine headache. It is currently not understood how the aura...... symptoms are related to the headache phase of migraine. Animal studies suggest that cortical spreading depression, the likely mechanism of migraine aura, causes disruption of the blood-brain barrier and noxious stimulation of trigeminal afferents leading to activation of brainstem nuclei and triggering...... of the anterior, middle and posterior circulation during spontaneous attacks of migraine with aura. Patients reported to our institution to undergo magnetic resonance imaging during the headache phase after presenting with typical visual aura. Nineteen patients were scanned during attacks and on an attack...

  16. No abnormalities of intrinsic brain connectivity in the interictal phase of migraine with aura

    DEFF Research Database (Denmark)

    Hougaard, Anders; Amin, F M; Magon, S

    2015-01-01

    BACKGROUND AND PURPOSE: Functional neuroimaging studies have shown hyperresponsiveness of cortical areas to visual stimuli in migraine patients with aura outside of attacks. This may be a key feature in the initiation of aura episodes and possibly also migraine headache attacks. It is unknown...... resting-state functional brain connectivity in migraineurs with aura outside of attacks using functional magnetic resonance imaging. METHODS: Forty patients suffering from migraine with visual aura and 40 individually age and gender matched healthy controls with no history or family history of migraine...... were investigated. Following advanced denoising, the data were analyzed both in a hypothesis-driven fashion, testing for abnormalities involving 27 different brain areas of potential relevance to migraine with aura including the cortical visual areas, the amygdala and peri-aqueductal grey matter...

  17. The Efficacy of Air Pollution Control Efforts: Evidence from AURA

    Science.gov (United States)

    Dickerson, Russell R.; Canty, Tim; Duncan, Bryan N.; Hao, He; Krotkov, Nickolay A.; Salawitch, Ross J.; Stehr, Jeffrey W.; Vinnikov, Konstatin

    2014-01-01

    Observations of NO2, SO2, and H2CO from OMI on AURA provide an excellent record of pollutant concentrations for the past decade. Abatement strategies to control criteria pollutants including ozone and fine particulate matter (PM2.5) have met with varying degrees of success. Sulfur controls had a profound impact on local SO2 concentrations and a measurable impact on PM2.5. Although substantial effort has gone into VOC control, ozone in the eastern US has responded dramatically to NOx emissions controls.

  18. TCDQ-TCT retraction and losses during asynchronous beam dump

    CERN Document Server

    Bracco, Chiara; Quaranta, Elena; CERN. Geneva. ATS Department

    2016-01-01

    The protection provided by the TCDQs in case of asynchronous beam dump depends strongly on their correct setup. They have to respect the strict hierarchy of the full collimation system and shield the tertiary collimators in the experimental regions. This MD aimed at performing asynchronous beam dump tests with different configurations, in order to assess the minimum allowed retraction between TCTs and TCDQs and, as a consequence, on the The protection provided by the TCDQs in case of asynchronous beam dump depends strongly on their correct setup. They have to respect the strict hierarchy of the full collimation system and shield the tertiary collimators in the experimental regions. This MD aimed at performing asynchronous beam dump tests with different configurations, in order to assess the minimum allowed retraction between TCTs and TCDQs and, as a consequence, on the β* reach.

  19. Pyrotechnic Actuator for Retracting Tubes Between MSL Subsystems

    Science.gov (United States)

    Gallon, John C.; Webster, Richard G.; Patterson, Keith D.; Orzewalla, Matthew A.; Roberts, Eric T.; Tuszynski, Andrew J.

    2010-01-01

    An apparatus, denoted the "retractuator" (a contraction of "retracting actuator"), was designed to help ensure clean separation between the cruise stage and the entry-vehicle subsystem of the Mars Science Laboratory (MSL) mission. The retractuator or an equivalent mechanism is needed because of tubes that (1) transport a heat-transfer fluid between the stages during flight and (2) are cut immediately prior to separation of the stages retractuator. The role of the retractuator is to retract the tubes, after they are cut and before separation of the subsystem, so that cut ends of the tubes do not damage thermal-protection coats on the entry vehicle and do not contribute to uncertainty of drag and consequent uncertainty in separation velocity.

  20. RETRACTED ARTICLE: Typhoon disasters and adaptive governance in Guangdong, China.

    Science.gov (United States)

    2014-03-01

    The peer-review process for the above article was found to have been compromised and inappropriately influenced by the first author, Yongdeng Lei. As a result the findings and conclusions of these articles cannot be relied upon. The Editor-in-Chief was misled in believing that she had accepted the article based upon a favorable review. The article is retracted based upon violation of the integrity of the peer review process.The first author and the publisher wish to retract this paper to preserve the integrity of material published in the journal. The publisher acknowledges that the integrity of the peer review process should have been subject to more rigorous verification to ensure the reviews provided were genuine and impartial. The publisher apologizes for any inconvenience rendered to the readers of the journal and wishes to assure the reader that measures have been taken to ensure that the peer review process is comprehensively checked to avoid a similar error occurring.

  1. Retracted: Spontaneous rectus sheath haematoma associated with rivaroxaban treatment.

    Science.gov (United States)

    Tas Tuna, A; Palabiyik, O; Beyaz, S G

    2015-08-01

    http://onlinelibrary.wiley.com/doi/10.1111/jcpt.12228/pdf The above article, published online on 10 November 2014 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the authors, the journal Editor in Chief, A. Li Wan Po, and John Wiley & Sons Ltd. The retraction has been agreed because, unknown to the authors, another group published a similar study based on the same material in the Indian Journal of Pharmacology: Kocayigit I, Can Y, Sahinkus S, et al. Spontaneous rectus sheath haematoma during rivaroxaban therapy. Indian Journal of Pharmacology. 2014;46(3):339-340. doi:10.4103/0253-7613.132193. © 2014 John Wiley & Sons Ltd.

  2. Retracted Article : Corruption And Economic Growth: A Survey Of ...

    African Journals Online (AJOL)

    This article was retracted by the journal Editor-in-Chief at the request of the authors (as of February 2013). http://dx.doi.org/10.4314/jorind.v6i1.42402 · AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and Conditions of Use ...

  3. Modified Dento - Alveolar Distraction Osteogenesis Technique for Rapid Canine Retraction

    Directory of Open Access Journals (Sweden)

    Sameer Patil

    2012-01-01

    Full Text Available Distraction Osteogenesis claims to reduce the duration of treatment as well aid in conservation of anchorage. With the introduction of Dento- alveolar distraction retraction of canine can now be done in about 2-3 weeks with minimal loss of anchorage and little/no root resorption. However, surgical procedure required for dento-alveolar distraction can cause significant swelling and post operative discomfort. Our small modification in the surgical procedure drastically reduces the discomfort and improves patient compliance.

  4. Duane retraction syndrome: causes, effects and management strategies

    Directory of Open Access Journals (Sweden)

    Kekunnaya R

    2017-10-01

    Full Text Available Ramesh Kekunnaya, Mithila Negalur Pediatric Ophthalmology and Strabismus Services, Child Sight Institute, Jasti V Ramannama Children’s Eye Care Center, KAR Campus, Hyderabad, India Abstract: Duane retraction syndrome (DRS is a congenital eye movement anomaly characterized by variable horizontal duction deficits, with narrowing of the palpebral fissure and globe retraction on attempted adduction, occasionally accompanied by upshoot or downshoot. The etiopathogenesis of this condition can be explained by a spectrum of mechanical, innervational, neurologic and genetic abnormalities occurring independently or which influence each other giving rise to patterns of clinical presentations along with a complex set of ocular and systemic anomalies. Huber type I DRS is the most common form of DRS with an earlier presentation, while Huber type II is the least common presentation. Usually, patients with unilateral type I Duane syndrome have esotropia more frequently than exotropia, those with type II have exotropia and those with type III have esotropia and exotropia occurring equally common. Cases of bilateral DRS may have variable presentation depending upon the type of presentation in each eye. As regards its management, DRS classification based on primary position deviation as esotropic, exotropic or orthotropic is more relevant than Huber’s classification before planning surgery. Surgical approach to these patients is challenging and must be individualized based on the amount of ocular deviation, abnormal head position, associated globe retraction and overshoots. Keywords: Duane syndrome, strabismus surgery, esotropia, overshoots

  5. Optimizing Anterior En Masse Retraction with Miniscrew Anchorage

    Directory of Open Access Journals (Sweden)

    Pavankumar Janardan Vibhute

    2011-01-01

    Full Text Available In severely protrusive patients, skeletal anchorage from miniscrew is often used to avoid anchorage loss with preferred miniscrew location near centre of resistance (Cres of posterior teeth. Biomechanical requirement for directing retraction force towards Cres of posterior teeth demands the insertion of miniscrew in loose mucosa, where risk of infection and failure increases. In addition, undesirable biomechanical side effects on anterior and posterior segments may be possible in all three planes, when continuous arch sliding mechanics are installed with miniscrew anchorage. This paper describes technique of molar-stabilizing power arm (MSPA for simultaneous intrusion and retraction of anteriors with miniscrew placement at attached gingiva between 1st molar and 2nd premolar. Advantages of this technique include (i the need of miniscrews placement in loose mucosa apically near the Cres of the posterior teeth is eliminated, (ii the risk of infection and miniscrew failure is lowered since the miniscrew is placed in attached gingiva rather than the loose mucosa, and (iii by adjusting vertical length or replacing MSPA, alteration of the retraction force vector is possible in all three planes; thus, need of removal and repositioning of the miniscrew (e.g., in correction of occlusal cant can be eliminated.

  6. Retractions of the gingival margins evaluated by holographic methods

    Science.gov (United States)

    Sinescu, Cosmin; Negrutiu, Meda Lavinia; Manole, Marius; de Sabata, Aldo; Rusu, Laura-Cristina; Stratul, Stefan; Dudea, Diana; Dughir, Ciprian; Duma, Virgil-Florin

    2015-05-01

    The periodontal disease is one of the most common pathological states of the teeth and gums system. The issue is that its evaluation is a subjective one, i.e. it is based on the skills of the dental medical doctor. As for any clinical condition, a quantitative evaluation and monitoring in time of the retraction of the gingival margins is desired. This phenomenon was evaluated in this study with a holographic method by using a He-Ne laser with a power of 13 mW. The holographic system we have utilized - adapted for dentistry applications - is described. Several patients were considered in a comparative study of their state of health - regarding their oral cavity. The impressions of the maxillary dental arch were taken from a patient during his/her first visit and after a period of six months. The hologram of the first model was superposed on the model cast after the second visit. The retractions of the gingival margins could be thus evaluated three-dimensionally in every point of interest. An evaluation of the retraction has thus been made. Conclusions can thus be drawn for the clinical evaluation of the health of the teeth and gums system of each patient.

  7. Glutamate excitotoxicity inflicts paranodal myelin splitting and retraction.

    Science.gov (United States)

    Fu, Yan; Sun, Wenjing; Shi, Yunzhou; Shi, Riyi; Cheng, Ji-Xin

    2009-08-20

    Paranodal myelin damage is observed in white matter injury. However the culprit for such damage remains unknown. By coherent anti-Stokes Raman scattering imaging of myelin sheath in fresh tissues with sub-micron resolution, we observed significant paranodal myelin splitting and retraction following glutamate application both ex vivo and in vivo. Multimodal multiphoton imaging further showed that glutamate application broke axo-glial junctions and exposed juxtaparanodal K+ channels, resulting in axonal conduction deficit that was demonstrated by compound action potential measurements. The use of 4-aminopyridine, a broad-spectrum K+ channel blocker, effectively recovered both the amplitude and width of compound action potentials. Using CARS imaging as a quantitative readout of nodal length to diameter ratio, the same kind of paranodal myelin retraction was observed with applications of Ca2+ ionophore A23187. Moreover, exclusion of Ca2+ from the medium or application of calpain inhibitor abolished paranodal myelin retraction during glutamate exposure. Examinations of glutamate receptor agonists and antagonists further showed that the paranodal myelin damage was mediated by NMDA and kainate receptors. These results suggest that an increased level of glutamate in diseased white matter could impair paranodal myelin through receptor-mediated Ca2+ overloading and subsequent calpain activation.

  8. Glutamate excitotoxicity inflicts paranodal myelin splitting and retraction.

    Directory of Open Access Journals (Sweden)

    Yan Fu

    2009-08-01

    Full Text Available Paranodal myelin damage is observed in white matter injury. However the culprit for such damage remains unknown. By coherent anti-Stokes Raman scattering imaging of myelin sheath in fresh tissues with sub-micron resolution, we observed significant paranodal myelin splitting and retraction following glutamate application both ex vivo and in vivo. Multimodal multiphoton imaging further showed that glutamate application broke axo-glial junctions and exposed juxtaparanodal K+ channels, resulting in axonal conduction deficit that was demonstrated by compound action potential measurements. The use of 4-aminopyridine, a broad-spectrum K+ channel blocker, effectively recovered both the amplitude and width of compound action potentials. Using CARS imaging as a quantitative readout of nodal length to diameter ratio, the same kind of paranodal myelin retraction was observed with applications of Ca2+ ionophore A23187. Moreover, exclusion of Ca2+ from the medium or application of calpain inhibitor abolished paranodal myelin retraction during glutamate exposure. Examinations of glutamate receptor agonists and antagonists further showed that the paranodal myelin damage was mediated by NMDA and kainate receptors. These results suggest that an increased level of glutamate in diseased white matter could impair paranodal myelin through receptor-mediated Ca2+ overloading and subsequent calpain activation.

  9. Retractions in the medical literature: how many patients are put at risk by flawed research?

    Science.gov (United States)

    Steen, R Grant

    2011-11-01

    Clinical papers so flawed that they are eventually retracted may put patients at risk. Patient risk could arise in a retracted primary study or in any secondary study that draws ideas or inspiration from a primary study. To determine how many patients were put at risk, we evaluated 788 retracted English-language papers published from 2000 to 2010, describing new research with humans or freshly derived human material. These primary papers-together with all secondary studies citing them-were evaluated using ISI Web of Knowledge. Excluded from study were 468 basic science papers not studying fresh human material; 88 reviews presenting older data; 22 case reports; 7 papers retracted for journal error and 23 papers unavailable on Web of Knowledge. Overall, 180 retracted primary papers (22.8%) met the inclusion criteria. Subjects enrolled and patients treated in 180 primary studies and 851 secondary studies were combined. Retracted papers were cited over 5000 times, with 93% of citations being research related, suggesting that ideas promulgated in retracted papers can influence subsequent research. Over 28 000 subjects were enrolled-and 9189 patients were treated-in 180 retracted primary studies. Over 400 000 subjects were enrolled-and 70 501 patients were treated-in 851 secondary studies which cited a retracted paper. Papers retracted for fraud (n=70) treated more patients per study (pclinical studies were tallied.

  10. Cooperative retraction of bundled type IV pili enables nanonewton force generation.

    Directory of Open Access Journals (Sweden)

    Nicolas Biais

    2008-04-01

    Full Text Available The causative agent of gonorrhea, Neisseria gonorrhoeae, bears retractable filamentous appendages called type IV pili (Tfp. Tfp are used by many pathogenic and nonpathogenic bacteria to carry out a number of vital functions, including DNA uptake, twitching motility (crawling over surfaces, and attachment to host cells. In N. gonorrhoeae, Tfp binding to epithelial cells and the mechanical forces associated with this binding stimulate signaling cascades and gene expression that enhance infection. Retraction of a single Tfp filament generates forces of 50-100 piconewtons, but nothing is known, thus far, on the retraction force ability of multiple Tfp filaments, even though each bacterium expresses multiple Tfp and multiple bacteria interact during infection. We designed a micropillar assay system to measure Tfp retraction forces. This system consists of an array of force sensors made of elastic pillars that allow quantification of retraction forces from adherent N. gonorrhoeae bacteria. Electron microscopy and fluorescence microscopy were used in combination with this novel assay to assess the structures of Tfp. We show that Tfp can form bundles, which contain up to 8-10 Tfp filaments, that act as coordinated retractable units with forces up to 10 times greater than single filament retraction forces. Furthermore, single filament retraction forces are transient, whereas bundled filaments produce retraction forces that can be sustained. Alterations of noncovalent protein-protein interactions between Tfp can inhibit both bundle formation and high-amplitude retraction forces. Retraction forces build over time through the recruitment and bundling of multiple Tfp that pull cooperatively to generate forces in the nanonewton range. We propose that Tfp retraction can be synchronized through bundling, that Tfp bundle retraction can generate forces in the nanonewton range in vivo, and that such high forces could affect infection.

  11. Effects of tonabersat on migraine with aura: a randomised, double-blind, placebo-controlled crossover study

    DEFF Research Database (Denmark)

    Hauge, Anne W; Asghar, Mohammed S; Schytz, Henrik W

    2009-01-01

    BACKGROUND: Migraine with aura is thought likely to be caused by cortical spreading depression (CSD). Tonabersat inhibits CSD, and we therefore investigated whether tonabersat has a preventive effect in migraine with aura. METHODS: In this randomised, double-blind, placebo-controlled crossover...... trial, 40 mg tonabersat once daily was compared with matched placebo in patients who had at least one aura attack per month during the past 3 months. Randomisation was by computer-generated list. Patients kept a detailed diary to enable objective diagnosis of each attack as migraine with aura, migraine...... without aura, or other type of headache. Primary endpoints were a reduction in aura attacks with or without headache and a reduction in migraine headache days with or without an aura. Analysis was per protocol. This trial is registered, number NCT00332007. FINDINGS: 39 patients were included in the study...

  12. The visibility of scientific misconduct: A review of the literature on retracted journal articles

    Science.gov (United States)

    Hesselmann, Felicitas; Graf, Verena; Schmidt, Marion; Reinhart, Martin

    2016-01-01

    Retractions of scientific articles are becoming the most relevant institution for making sense of scientific misconduct. An increasing number of retracted articles, mainly attributed to misconduct, is currently providing a new empirical basis for research about scientific misconduct. This article reviews the relevant research literature from an interdisciplinary context. Furthermore, the results from these studies are contextualized sociologically by asking how scientific misconduct is made visible through retractions. This study treats retractions as an emerging institution that renders scientific misconduct visible, thus, following up on the sociology of deviance and its focus on visibility. The article shows that retractions, by highlighting individual cases of misconduct and general policies for preventing misconduct while obscuring the actors and processes through which retractions are effected, produce highly fragmented patterns of visibility. These patterns resemble the bifurcation in current justice systems. PMID:28943647

  13. Abnormal Connectivity Within Executive Resting-State Network in Migraine With Aura.

    Science.gov (United States)

    Tessitore, Alessandro; Russo, Antonio; Conte, Francesca; Giordano, Alfonso; De Stefano, Manuela; Lavorgna, Luigi; Corbo, Daniele; Caiazzo, Giuseppina; Esposito, Fabrizio; Tedeschi, Gioacchino

    2015-06-01

    To evaluate the executive control network connectivity integrity in patients with migraine with aura, in the interictal period, in comparison to patients with migraine without aura and healthy controls. Using resting-state functional magnetic resonance imaging, we compared executive control network functional connectivity in 20 patients with migraine with aura vs 20 sex and age-matched patients with migraine without aura and 20 healthy controls, and assessed the correlation between executive control network functional connectivity and clinical features of patients with migraine. We used voxel-based morphometry and diffusion tensor imaging to investigate potential structural or microstructural changes. Neuropsychological data revealed no significant executive dysfunction in patients with migraine. Resting-state functional magnetic resonance imaging showed significant group differences in right middle frontal gyrus (Talairach coordinates x, y, z: +26, +2, +48) and dorsal anterior cingulate cortex (Talairach coordinates x, y, z: +6, +13, +49), indicating that these areas had a decreased component activity in both patients with migraine with and without aura when compared with healthy controls. Conversely, there were no significant differences in the executive control network functional connectivity between patients with migraine with and without aura (P aura, in the interictal period. Although this functional phenomenon is present in the absence of clinically relevant executive deficits, it may reflect a vulnerability to executive high-demanding conditions of daily living activities in patients with migraine. © 2015 American Headache Society.

  14. Heterogenous migraine aura symptoms correlate with visual cortex functional magnetic resonance imaging responses.

    Science.gov (United States)

    Arngrim, Nanna; Hougaard, Anders; Ahmadi, Khazar; Vestergaard, Mark Bitsch; Schytz, Henrik Winther; Amin, Faisal Mohammad; Larsson, Henrik Bo Wiberg; Olesen, Jes; Hoffmann, Michael B; Ashina, Messoud

    2017-12-01

    Migraine aura is sparsely studied due to the highly challenging task of capturing patients during aura. Cortical spreading depression (CSD) is likely the underlying phenomenon of aura. The possible correlation between the multifaceted phenomenology of aura symptoms and the effects of CSD on the brain has not been ascertained. Five migraine patients were studied during various forms of aura symptoms induced by hypoxia, sham hypoxia, or physical exercise with concurrent photostimulation. The blood oxygenation level-dependent (BOLD) functional magnetic resonance imaging (fMRI) signal response to visual stimulation was measured in retinotopic mapping-defined visual cortex areas V1 to V4. We found reduced BOLD response in patients reporting scotoma and increased response in patients who only experienced positive symptoms. Furthermore, patients with bilateral visual symptoms had corresponding bihemispherical changes in BOLD response. These findings suggest that different aura symptoms reflect different types of cerebral dysfunction, which correspond to specific changes in BOLD signal reactivity. Furthermore, we provide evidence of bilateral CSD recorded by fMRI during bilateral aura symptoms. Ann Neurol 2017;82:925-939. © 2017 American Neurological Association.

  15. Intact blood-brain barrier during spontaneous attacks of migraine without aura

    DEFF Research Database (Denmark)

    Amin, F M; Hougaard, A; Cramer, S P

    2017-01-01

    BACKGROUND AND PURPOSE: The integrity of the blood-brain barrier (BBB) has been questioned in migraine, but BBB permeability has never been investigated during spontaneous migraine attacks. In the present study, BBB permeability during spontaneous attacks of migraine without aura was investigated...... compared to an interictal state. METHODS: Seventy-four patients suffering from migraine without aura were recruited to participate in this cross-sectional dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) study. The patients were instructed to report at the hospital for DCE-MRI scan during...... that the BBB permeability during spontaneous migraine attacks without aura was unchanged....

  16. Epilepsia do lobo temporal com aura de prazer : relato de caso

    Directory of Open Access Journals (Sweden)

    TANURI FABIANO DA CUNHA

    2000-01-01

    Full Text Available Relatamos o caso de uma paciente com epilepsia do lobo temporal e "sensação de orgasmo" como aura epiléptica. Há controvérsia na literatura a respeito da existência do prazer e do êxtase como manifestação de aura epiléptica. Neste caso, ficou evidenciada a presença da aura de prazer, através da investigação clínica, eletrencefalograma e remissão das crises com a terapêutica adotada (fenitoína.

  17. Walter Benjamin's concept of aura and the cultural industry

    Directory of Open Access Journals (Sweden)

    Bráulio Santos Rabelo de Araújo

    2010-12-01

    Full Text Available Trata-se de uma análise do texto A obra de arte na era da reprodutibilidade técnica, de 1935, de Walter Benjamin, no qual o autor analisa as alterações provocadas pelas novas técnicas de produção artística na esfera da cultura, e desenvolve, como elemento principal, a tese de a reprodutibilidade técnica provocar a superação da aura pela obra de arte. Tendo como apoio o contraste do texto de Benjamin com o texto A indústria cultural: O esclarecimento como mistificação das massas, de Theodor Adorno e Max Horkheimer, de 1947, e a observação da produção do cinema, da música e do livro (artes necessariamente reprodutíveis, este artigo (a analisa a tese da superação do conceito de aura pela obra de arte na era da reprodutibilidade técnica, (b contrasta essa tese com a reflexão sobre indústria cultural de Adorno e Horkheimer e com as características da obra de arte produzida no decorrer do século 20 e início do século 21, e (c apresenta as contribuições que podem ser retiradas dessa análise para a atual reflexão a respeito dos impactos da Internet e das tecnologias digitais sobre a produção cultural contemporânea. Como resultado principal e do qual decorre outras conclusões, o artigo considera que as técnicas analisadas por Benjamin, apesar de terem tornado a obra de arte independente de um substrato único, não a emanciparam de seu caráter aurático. Os elementos centrais da aura (autenticidade e unicidade não foram superados, mas, ao contrário, adaptaram-se às mudanças técnicas, adaptação essa que ocorreu em torno da industrialização, a qual marcou a produção cultural no século 20.

  18. Biologic targeting in the treatment of inflammatory bowel diseases [Retraction

    Directory of Open Access Journals (Sweden)

    Bosani M

    2014-01-01

    Full Text Available Bosani M, Ardizzone S, Porro GB. Biologics: Targets and Therapy. 2009;3:77–97.This paper has been retracted after we were made aware that it contains a large amount of reused, and uncited material that was not placed within quotation marks.The following statement has been supplied by Dr Sandro Ardizzone:The review entitled "Biologic targeting in the treatment of inflammatory bowel disease" has been commissioned by this journal and published in 2009 (Matteo Bosani, Sandro Ardizzone, Gabriele Bianchi Porro. Biologics: Targets & Therapy 2009;3:77–97. The paper was written by our young coworker (Dr M Bosani. He has consulted many papers, including our previous reviews published years before. The not perfect knowledge of English language has greatly influenced the writing of the paper itself. So he saved in word file several parts of our previous papers (Ardizzone S, Bianchi Porro G. Inflammatory bowel disease: new insights into pathogenesis and treatment. J Intern Med 2002;252:475–496 – Ardizzone S, Bianchi Porro G. Biologic therapy for inflammatory bowel disease. Drugs 2005:2253–2286, and then transferred to the final paper. He was unaware as we are, of the fact that he could not reuse previously published material in other journals. The reuse of this material was made in good faith.Taking our responsibility for what happened, we intend to apologize for this inconvenience to the Editor (Dr Doris Benbrook and Publisher (Dr Tim Hill. Moreover, for the reasons mentioned above, I consider appropriate to retract the paper itself.This retraction relates to this paper.

  19. Site Protection Efforts at the AURA Observatory in Chile

    Science.gov (United States)

    Smith, R. Chris; Sanhueza, Pedro; Smith, Malcolm G.

    2016-10-01

    The AURA Observatory site in northern Chile, which includes Cerro Tololo and Cerro Pachon, has been operational for over 50 years now, facing a variety of challenges to its long-term future. The site now hosts over 20 operational telescopes, ranging from small projects with 0.4m telescopes to the Blanco 4m, the SOAR 4.1m, and the 8m Gemini-South telescopes. In addition, we have recently begun the construction of the Large Synoptic Survey Telescope (LSST) on the summit of Cerro Pachon. We summarize our efforts over the past 20-30 years to highlight the importance of site protection through education and public outreach as well as through more recent promotion of IDA certifications in the region and support for the World Heritage initiatives described by others in this conference.

  20. Aura MLS Cloud Measurements: First-Year Results

    Science.gov (United States)

    Jiang, Jonathan H.; Wu, Dong L.

    2005-01-01

    Aura MLS provides the first vertical upper tropospheric cloud profiling from space, enabling global survey of the vertical structure of cloud systems, with seasonal and geographical variations, needed to evaluate the way clouds are parameterized in global models, thereby contributing to the understanding of cloud-climate feedbacks, and improved weather and climate predictions. The vertical structure of cloud systems is fundamentally important for understanding how clouds affect both their regional and large-scale atmospheric and radiative environments. The regional cloud profiles provide a critical tests of important parameterizations that enable the calculation of radiative flux profiles and heating rates throughout the atmospheric column, which in turn also regulates the water and energy cycles in the upper troposphere

  1. Direct Observations of PMC Local Time Variations by Aura OMI

    Science.gov (United States)

    DeLand, Matthew T.; Shettle, Eric P.; Thomas, Gary E.; Olivero, John J.

    2010-01-01

    The Ozone Monitoring Instrument (OMI) on the Aura satellite obtains unique measurements for polar mesospheric cloud (PMC) analysis. Its wide cross-track viewing swath and high along-track spatial resolution makes it possible to directly evaluate PMC occurrence frequency and brightness variations between 6S" and 8S' latitude as a function of local time over a 12-14 h continuous period. OMI PMC local time variations are closely coupled to concurrent variations in measurement scattering angle, so that ice phase function effects must be considered when interpreting the observations. Two different phase functions corresponding to bright and faint clouds are examined in this analysis. OMI observations show maximum frequency and albedo values at 8-10 h local time in the Northern Hemisphere, with decreasing amplitude at higher latitudes. Southern Hemisphere values reach a minimum at 18-20 h LT. Larger variations are seen in Northern Hemisphere data. No statistically significant longitudinal dependence was seen.

  2. Summary of Aqua, Aura, and Terra High Interest Events

    Science.gov (United States)

    Newman, Lauri

    2015-01-01

    Single-obs tracking Sparsely tracked objects are an unfortunate reality of CARA operations Terra vs. 32081: new track with bad data was included in OD solution for secondary object and risk became high CARA and JSpOC discussed tracking and OSAs threw out the bad data. Event no longer presented high risk based on new OD Improvement: CARA now sends JSpOC a flag indicating when a single obs is included, so OSAs can evaluate if manual update to OD is required. Missing ASW OCMsAura vs. 87178, TCA: 317 at 08:04 UTC. Post-maneuver risk (conjunction was identified in OO results)CARA confirmed with JSpOC that ASW OCMs should have been received in addition to OO OCMsJSpOC corrected the manual error in their script that prevented the data from being delivered to CARAJSpOC QAd their other scripts to ensure this error did not exist in other places.

  3. Simultaneous Occurrence of Duane Retraction Syndrome with Marfan Syndrome

    Directory of Open Access Journals (Sweden)

    Mihir Kothari

    2011-01-01

    Full Text Available Marfan syndrome (MFS is an autosomal dominant disorder of connective tissue, while Duane retraction syndrome (DRS is a congenital cranial dysinnervation disorder (CCDD which can be transmitted as autosomal dominant disorder in 5–10% of patients. In this paper, we present an 8-year-old girl who presented with left eye DRS and bilateral subluxation of the lens associated with MFS in absence of familial involvement. To our knowledge this is the first case report of DRS with MFS. The occurrence of these syndromes together is very rare and appears to be coincidental.

  4. On permanent retraction of the fingers, according to Dupuytren.

    Science.gov (United States)

    Dohlem, R

    1996-06-01

    During a lecture on clinical surgery that he gave at the Hôtel-Dieu Hospital in Paris in 1831, Guillaume Dupuytren established the nature of "Permanent retraction of the fingers", that has been designated Dupuytren's contracture since the end of the XIXth century. The nosological individualization of this soft tissue rheumatism is analyzed based on a review of Dupuytren's lectures and of writings by XIXth century practitioners; the other two conditions included in Dupuytren's diathesis, namely Ledderhose's contracture and Peyronie's disease, are also discussed.

  5. Validation of Aura Microwave Limb Sounder HCl Measurements

    Science.gov (United States)

    Froidevaux, L.; Jiang, Y. B.; Lambert, A.; Livesey, N. J.; Read, W. G.; Waters, J. W.; Fuller, R. A.; Marcy, T. P.; Popp, P. J.; Gao, R. S.; hide

    2008-01-01

    The Earth Observing System (EOS) Microwave Limb Sounder (MLS) aboard the Aura satellite has provided daily global HCl profiles since August 2004. We provide a characterization of the resolution, random and systematic uncertainties, and known issues for the version 2.2 MLS HCl data. The MLS sampling allows for comparisons with many (1500 to more than 3000) closely matched profiles from the Halogen Occultation Experiment (HALOE) and Atmospheric Chemistry Experiment Fourier Transform Spectrometer (ACE-FTS). These data sets provide HCl latitudinal distributions that are, overall, very similar to those from (coincident) MLS profiles, although there are some discrepancies in the upper stratosphere between the MLS and HALOE gradients. As found in previous work, MLS and ACE HCl profiles agree very well (within approximately 5%, on average), but the MLS HCl abundances are generally larger (by 10-20%) than HALOE HCl. The bias versus HALOE is unlikely to arise mostly from MLS, as a similar systematic bias (of order 15%) is not observed between average MLS and balloon-borne measurements of HCl, obtained over Fort Sumner, New Mexico, in 2004 and 2005. At the largest pressure (147 hPa) for MLS HCl, a high bias (approximately 0.2 ppbv) is apparent in analyses of low to midlatitude data versus in situ aircraft chemical ionization mass spectrometry (CIMS) HCl measurements from the Aura Validation Experiment (AVE) campaigns in 2004, 2005, and 2006; this bias is also observed in comparisons of MLS and aircraftHCl/O3 correlations. Good agreement between MLS and CIMS HCl is obtained at 100 to 68 hPa. The recommended pressure range for MLS HCl is from 100 to 0.15 hPa.

  6. Migraine-Like Visual Auras Among Traumatized Cambodians with PTSD: Fear of Ghost Attack and Other Disasters.

    Science.gov (United States)

    Hinton, Devon E; Reis, Ria; de Jong, Joop

    2017-10-10

    This article profiles visual auras among traumatized Cambodian refugees attending a psychiatric clinic. Thirty-six percent (54/150) had experienced an aura in the previous 4 weeks, almost always phosphenes (48% [26/54]) or a scintillating scotoma (74% [40/54]). Aura and PTSD were highly associated: patients with visual aura in the last month had greater PTSD severity, 3.6 (SD = 1.8) versus 1.9 (SD = 1.6), t = 10.2 (df = 85), p PTSD had a higher rate of visual aura in the last month, 69% (22/32) versus 13% (7/55), odds ratio 15.1 (5.1-44.9), p lying or sitting position, i.e., orthostasis, with the most common sequence being an aura triggered upon orthostasis during a migraine, experienced by 60% of those with aura. The visual aura was often catastrophically interpreted: as the dangerous assault of a supernatural being, most commonly the ghost of someone who died in the Pol Pot period. Aura often triggered flashback. Illustrative cases are provided. The article suggests the existence of local biocultural ontologies of trauma as evinced by the centrality of visual auras among Cambodian refugees.

  7. MLS/Aura L2 Hydrogen Cyanide (HCN) Mixing Ratio V003

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2HCN is the EOS Aura Microwave Limb Sounder (MLS) standard product for hydrogen cyanide derived from radiances measured primarily by the 190 GHz radiometer. The...

  8. TES/Aura L2 NO2 Limb Special Observation V006

    Data.gov (United States)

    National Aeronautics and Space Administration — The TES Aura L2 NO2 data consist of information for one molecular species for an entire Global Survey or Special Observation. TES Level 2 data contain retrieved...

  9. TES/Aura L2 HDO Limb Special Observation V006

    Data.gov (United States)

    National Aeronautics and Space Administration — The TES Aura L2 HDO data consist of information for one molecular species for an entire Global Survey or Special Observation. TES Level 2 data contain retrieved...

  10. TES/Aura L2 HNO3 Limb Special Observation V006

    Data.gov (United States)

    National Aeronautics and Space Administration — The TES Aura L2 HNO3 data consist of information for one molecular species for an entire Global Survey or Special Observation. TES Level 2 data contain retrieved...

  11. TES/Aura L2 H2O Limb V006

    Data.gov (United States)

    National Aeronautics and Space Administration — The TES Aura L2 H2O data consist of information for one molecular species for an entire Global Survey or Special Observation. TES Level 2 data contain retrieved...

  12. TES/Aura L3 CO2 Lite Monthly Gridded V003

    Data.gov (United States)

    National Aeronautics and Space Administration — The TES Aura L3 CO2 data consist of daily atmospheric temperature and VMR for the atmospheric species. Data are provided at 2 degree latitude X 4 degree longitude...

  13. MLS/Aura L2 Nitric Acid (HNO3) Mixing Ratio V003

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2HNO3 is the EOS Aura Microwave Limb Sounder (MLS) standard product for nitric acid derived from radiances measured by the 240 GHz radiometer at and below 10 hPa,...

  14. MLS/Aura L2 Nitric Acid (HNO3) Mixing Ratio V002

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2HNO3 is the EOS Aura Microwave Limb Sounder (MLS) standard product for nitric acid derived from radiances measured by the 240 GHz radiometer at and below 10 hPa,...

  15. TES/Aura L2 Formic Acid Lite Nadir V006

    Data.gov (United States)

    National Aeronautics and Space Administration — The TES Aura L2 Formic Acid data consist of information for one molecular species for an entire Global Survey or Special Observation. TES Level 2 data contain...

  16. MLS/Aura L2 Hypochlorous Acid (HOCL) Mixing Ratio V003

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2HOCL is the EOS Aura Microwave Limb Sounder (MLS) standard product for hypochlorous acid derived from radiances measured primarily by the 640 GHz radiometer. The...

  17. MLS/Aura Level 2 Nitric Acid (HNO3) Mixing Ratio V004

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2HNO3 is the EOS Aura Microwave Limb Sounder (MLS) standard product for nitric acid derived from radiances measured by the 240 GHz radiometer at and below 10 hPa,...

  18. MLS/Aura L2 Hypochlorous Acid (HOCL) Mixing Ratio V002

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2HOCL is the EOS Aura Microwave Limb Sounder (MLS) standard product for hypochlorous acid derived from radiances measured primarily by the 640 GHz radiometer. The...

  19. MLS/Aura Level 2 Hypochlorous Acid (HOCl) Mixing Ratio V004

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2HOCL is the EOS Aura Microwave Limb Sounder (MLS) standard product for hypochlorous acid derived from radiances measured primarily by the 640 GHz radiometer. The...

  20. TES/Aura L2 H2O Lite Nadir V006

    Data.gov (United States)

    National Aeronautics and Space Administration — The TES Aura L2 H2O data consist of information for one molecular species for an entire Global Survey or Special Observation. TES Level 2 data contain retrieved...

  1. MLS/Aura L2 Hydrogen Cyanide (HCN) Mixing Ratio V002

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2HCN is the EOS Aura Microwave Limb Sounder (MLS) standard product for hydrogen cyanide derived from radiances measured primarily by the 190 GHz radiometer. The...

  2. MLS/Aura L2 Hydroperoxy (HO2) Mixing Ratio V002

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2HO2 is the EOS Aura Microwave Limb Sounder (MLS) standard product for hydroperoxy derived from radiances measured in two bands from the 640 GHz radiometer. The...

  3. MLS/Aura Level 2 Bromine Monoxide (BrO) Mixing Ratio V004

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2BRO is the EOS Aura Microwave Limb Sounder (MLS) standard product for bromine monoxide derived from radiances measured by the 640 GHz radiometer. The current...

  4. MLS/Aura Level 2 Ozone (O3) Mixing Ratio V004

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2O3 is the EOS Aura Microwave Limb Sounder (MLS) standard product for ozone derived from radiances measured by the 240 GHz radiometer. The current version is 4.2....

  5. Explicit diagnostic criteria for transient ischemic attacks to differentiate it from migraine with aura

    DEFF Research Database (Denmark)

    Lebedeva, Elena R; Gurary, Natalia M; Gilev, Denis V

    2018-01-01

    and mimics, particularly migraine with aura with its varied symptomatology. In other disease areas, explicit diagnostic criteria have improved sensitivity and specificity of diagnoses. We therefore present novel explicit diagnostic criteria for transient ischemic attacks tested for sensitivity...... and for specificity against migraine with aura. Methods The proposed criteria were developed using the format of the international headache classification. We drew upon the existing literature about clinical characteristics and diagnosis of migraine with aura and transient ischemic attacks. We tested the criteria...... within 24 hours without presence of new infarction on magnetic resonance imaging with diffusion weighted imaging (n = 112) or computed tomography (n = 8). These criteria were also tested for specificity against a Danish (n = 1390) and a Russian (n = 152) material of patients with migraine with aura...

  6. MLS/Aura L2 Hydroperoxy (HO2) Mixing Ratio V003

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2HO2 is the EOS Aura Microwave Limb Sounder (MLS) standard product for hydroperoxy derived from radiances measured in two bands from the 640 GHz radiometer. The...

  7. MLS/Aura L2 Bromine Monoxide (BRO) Mixing Ratio V002

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2BRO is the EOS Aura Microwave Limb Sounder (MLS) standard product for bromine monoxide derived from radiances measured by the 640 GHz radiometer. The current...

  8. MLS/Aura L1 Radiances from Filter Banks for GHz V004

    Data.gov (United States)

    National Aeronautics and Space Administration — ML1RADG is the EOS Aura Microwave Limb Sounder (MLS) product containing the level 1 radiances from the filter banks for the GHz radiometers. The current version is...

  9. MLS/Aura Level 2 Hydrogen Chloride (HCl) Mixing Ratio V004

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2HCL is the EOS Aura Microwave Limb Sounder (MLS) standard product for hydrogen chloride derived from radiances measured primarily by the 640 GHz radiometer. The...

  10. MLS/Aura Level 2 Water Vapor (H2O) Mixing Ratio V004

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2H2O is the EOS Aura Microwave Limb Sounder (MLS) standard product for water vapor derived from radiances measured primarily by the 190 GHz radiometer. The current...

  11. EOS Aura Mission Status at Earth Science Constellation MOWG Meeting @ LASP (Boulder, CO) April 13, 2016

    Science.gov (United States)

    Guit, William J.; Fisher, Dominic

    2016-01-01

    Presentation reflects EOS Aura mission status, spacecraft subsystems summary, recent and planned activities, inclination adjust maneuvers, propellant usage, orbit maintenance maneuvers, conjunction assessment events, orbital parameters trends and predictions.

  12. MLS/Aura L2 Hydroxyl (OH) Mixing Ratio V002

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2OH is the EOS Aura Microwave Limb Sounder (MLS) standard product for hydroxyl derived from radiances measured by the THz radiometer. The current version is 2.2....

  13. MLS/Aura Level 2 Carbon Monoxide (CO) Mixing Ratio V004

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2CO is the EOS Aura Microwave Limb Sounder (MLS) standard product for carbon monoxide derived from radiances measured by the 640 GHz radiometer. The current...

  14. MLS/Aura Level 2 Hydroxyl (OH) Mixing Ratio V004

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2OH is the EOS Aura Microwave Limb Sounder (MLS) standard product for hydroxyl derived from radiances measured by the THz radiometer. The current version is 4.2....

  15. MLS/Aura L2 Bromine Monoxide (BRO) Mixing Ratio V003

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2BRO is the EOS Aura Microwave Limb Sounder (MLS) standard product for bromine monoxide derived from radiances measured by the 640 GHz radiometer. The current...

  16. MLS/Aura L2 Sulfur Dioxide (SO2) Mixing Ratio V002

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2SO2 is the EOS Aura Microwave Limb Sounder (MLS) standard product for sulfur dioxide derived from radiances measured by the 240 GHz radiometer. The current...

  17. HIRDLS/Aura Level 3 Dinitrogen Pentoxide (N2O5) Zonal Fourier Coefficients V007

    Data.gov (United States)

    National Aeronautics and Space Administration — The "HIRDLS/Aura Level 3 Dinitrogen Pentoxide (N2O5) Zonal Fourier Coefficients" version 7 data product (H3ZFCN2O) contains the entire mission (~3 years) of HIRDLS...

  18. HIRDLS/Aura Level 3 Temperature Zonal Fourier Coefficients V007

    Data.gov (United States)

    National Aeronautics and Space Administration — The "HIRDLS/Aura Level 3 Temperature Zonal Fourier Coefficients" version 7 data product (H3ZFCT) contains the entire mission (~3 years) of HIRDLS data expressed as...

  19. MLS/Aura L2 Chlorine Monoxide (ClO) Mixing Ratio V002

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2CLO is the EOS Aura Microwave Limb Sounder (MLS) standard product for chlorine monoxide derived from radiances measured primarily by the 640 GHz radiometer. The...

  20. MLS/Aura Level 2 Methyl Chloride (CH3CL) Mixing Ratio V004

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2CH3CL is the EOS Aura Microwave Limb Sounder (MLS) standard product for methyl chloride derived from radiances measured by the 640 GHz radiometer. The current...

  1. Structural gray matter abnormalities in migraine relate to headache lateralization, but not aura

    DEFF Research Database (Denmark)

    Hougaard, Anders; Amin, Faisal M; Hoffmann, Michael B

    2015-01-01

    BACKGROUND: The hallmark of migraine aura (MA) is transient cortical dysfunction but it is not known if MA is associated with structural cortical or subcortical changes. To determine the relation between MA and structural gray matter abnormalities, we studied a unique sample of 20 patients...... with frequent side-locked MA, i.e. visual aura consistently occurring in the same hemifield. METHODS: We applied a highly sensitive within-patient design to assess anatomical differences with both voxel-based morphometry and surface-based morphometry on a whole-hemisphere level and for specific anatomical...... regions of interest. Within-subject comparisons were made with regard to aura symptoms (N = 20 vs 20) and with regard to headache (N = 13 vs 13). RESULTS: We found no differences in gray matter structure with regard to aura symptoms in MA patients. Comparing the typical migraine headache side...

  2. MLS/Aura L2 Diagnostics, Geophysical Parameter Grid V002

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2DGG is the EOS Aura Microwave Limb Sounder (MLS) product containing geophysical diagnostic quantities pertaining directly to the standard geophysical data...

  3. MLS/Aura L2 Hydrogen Chloride (HCl) Mixing Ratio V002

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2HCL is the EOS Aura Microwave Limb Sounder (MLS) standard product for hydrogen chloride derived from radiances measured primarily by the 640 GHz radiometer. The...

  4. MLS/Aura L1 Radiances from Filter Banks for GHz V002

    Data.gov (United States)

    National Aeronautics and Space Administration — ML1RADG is the EOS Aura Microwave Limb Sounder (MLS) product containing the level 1 radiances from the filter banks for the GHz radiometers. The current version is...

  5. MLS/Aura L1 Radiances from Filter Banks for THz V004

    Data.gov (United States)

    National Aeronautics and Space Administration — ML1RADT is the EOS Aura Microwave Limb Sounder (MLS) product containing the level 1 radiances from the filter banks for the THz radiometer. The current version is...

  6. MLS/Aura L1 Radiances from Digital Autocorrelators V002

    Data.gov (United States)

    National Aeronautics and Space Administration — ML1RADD is the EOS Aura Microwave Limb Sounder (MLS) product containing the level 1 radiances from the digital autocorrelators. The current version is 2.3. Data...

  7. MLS/Aura L2 Methyl Cyanide (CH3CN) Mixing Ratio V002

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2CH3CN is the EOS Aura Microwave Limb Sounder (MLS) standard product for methyl cyanide derived from radiances measured by the 190 GHz radiometer. The current...

  8. MLS/Aura L1 Radiances from Filter Banks for THz V002

    Data.gov (United States)

    National Aeronautics and Space Administration — ML1RADT is the EOS Aura Microwave Limb Sounder (MLS) product containing the level 1 radiances from the filter banks for the THz radiometer. The current version is...

  9. MLS/Aura L2 Water Vapor (H2O) Mixing Ratio V002

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2H2O is the EOS Aura Microwave Limb Sounder (MLS) standard product for water vapor derived from radiances measured primarily by the 190 GHz radiometer. The current...

  10. HIRDLS/Aura Level 3 Ozone (O3) Zonal Fourier Coefficients V007

    Data.gov (United States)

    National Aeronautics and Space Administration — The "HIRDLS/Aura Level 3 Ozone (O3) Zonal Fourier Coefficients" version 7 data product (H3ZFCO3) contains the entire mission (~3 years) of HIRDLS data expressed as...

  11. MLS/Aura L1 Orbit/Attitude and Tangent Point Geolocation Data V004

    Data.gov (United States)

    National Aeronautics and Space Administration — ML1OA is the EOS Aura Microwave Limb Sounder (MLS) product containing the level 1 orbit attitude and tangent point geolocation data. The current version is 4.2. Data...

  12. MLS/Aura Level 2 Sulfur Dioxide (SO2) Mixing Ratio V004

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2SO2 is the EOS Aura Microwave Limb Sounder (MLS) standard product for sulfur dioxide derived from radiances measured by the 240 GHz radiometer. The current...

  13. MLS/Aura L2 Hydrogen Chloride (HCl) Mixing Ratio V003

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2HCL is the EOS Aura Microwave Limb Sounder (MLS) standard product for hydrogen chloride derived from radiances measured primarily by the 640 GHz radiometer. The...

  14. MLS/Aura L2 Methyl Chloride (CH3CL) Mixing Ratio V003

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2CH3CL is the EOS Aura Microwave Limb Sounder (MLS) standard product for methyl chloride derived from radiances measured by the 640 GHz radiometer. The current...

  15. MLS/Aura Near-Real-Time L2 Carbon Monoxide (CO) Mixing Ratio V003

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2CO_NRT is the EOS Aura Microwave Limb Sounder (MLS) Near-Real-Time (NRT) product for carbon monoxide (CO). This product contains daily CO profiles taken from the...

  16. TES/Aura L3 H2O Monthly Gridded V004

    Data.gov (United States)

    National Aeronautics and Space Administration — The TES Aura L3 H2O data consist of daily atmospheric temperature and VMR for the atmospheric species. Data are provided at 2 degree latitude X 4 degree longitude...

  17. HIRDLS/Aura Level 3 Nitric Acid (HNO3) Zonal Fourier Coefficients V007

    Data.gov (United States)

    National Aeronautics and Space Administration — The "HIRDLS/Aura Level 3 Nitric Acid (HNO3) Zonal Fourier Coefficients" version 7 data product (H3ZFCHNO3) contains the entire mission (~3 years) of HIRDLS data...

  18. MLS/Aura L1 Orbit/Attitude and Tangent Point Geolocation Data V002

    Data.gov (United States)

    National Aeronautics and Space Administration — ML1OA is the EOS Aura Microwave Limb Sounder (MLS) product containing the level 1 orbit attitude and tangent point geolocation data. The current version is 2.3. Data...

  19. MLS/Aura L2 Nitrous Oxide (N2O) Mixing Ratio V003

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2N2O is the EOS Aura Microwave Limb Sounder (MLS) standard product for nitrous oxide derived from radiances measured primarily by the 640 GHz radiometer (Band 12)...

  20. MLS/Aura L2 Nitrous Oxide (N2O) Mixing Ratio V002

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2N2O is the EOS Aura Microwave Limb Sounder (MLS) standard product for nitrous oxide derived from radiances measured primarily by the 640 GHz radiometer (Band 12)...

  1. MLS/Aura Level 2 Nitrous Oxide (N2O) Mixing Ratio V004

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2N2O is the EOS Aura Microwave Limb Sounder (MLS) standard product for nitrous oxide derived from radiances measured primarily by the 640 GHz radiometer (Band 12)...

  2. MLS/Aura Level 2 Methanol (CH3OH) Mixing Ratio V004

    Data.gov (United States)

    National Aeronautics and Space Administration — At this time it is recommended that these data not be used pending further validation. ML2CH3OH is the EOS Aura Microwave Limb Sounder (MLS) standard product for...

  3. MLS/Aura L2 Diagnostics, Geophysical Parameter Grid V003

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2DGG is the EOS Aura Microwave Limb Sounder (MLS) product containing geophysical diagnostic quantities pertaining directly to the standard geophysical data...

  4. MLS/Aura Level 2 Diagnostics, Geophysical Parameter Grid V004

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2DGG is the EOS Aura Microwave Limb Sounder (MLS) product containing geophysical diagnostic quantities pertaining directly to the standard geophysical data...

  5. TES/Aura L2 H2O Limb Special Observation V006

    Data.gov (United States)

    National Aeronautics and Space Administration — The TES Aura L2 H2O data consist of information for one molecular species for an entire Global Survey or Special Observation. TES Level 2 data contain retrieved...

  6. TES/Aura L2 O3 Limb Special Observation V006

    Data.gov (United States)

    National Aeronautics and Space Administration — The TES Aura L2 O3 data consist of information for one molecular species for an entire Global Survey or Special Observation. TES Level 2 data contain retrieved...

  7. HIRDLS/Aura Level 3 Chlorofluorocarbon-11 (CFC-11) Zonal Fourier Coefficients V007

    Data.gov (United States)

    National Aeronautics and Space Administration — The "HIRDLS/Aura Level 3 Chlorofluorocarbon-11 (CFC-11) Zonal Fourier Coefficients" version 7 data product (H3ZFCCFC11) contains the entire mission (~3 years) of...

  8. MLS/Aura L2 Carbon Monoxide (CO) Mixing Ratio V002

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2CO is the EOS Aura Microwave Limb Sounder (MLS) standard product for carbon monoxide derived from radiances measured by the 640 GHz radiometer. The current...

  9. TES/Aura L3 CH4 Daily Gridded V004

    Data.gov (United States)

    National Aeronautics and Space Administration — The TES Aura L3 CH4 data consist of daily averages of atmospheric Methane for atmospheric species. Data are provided at 2 degree latitude X 4 degree longitude...

  10. TES/Aura L3 CH4 Monthly Gridded V004

    Data.gov (United States)

    National Aeronautics and Space Administration — The TES Aura L3 CH4 data consist of monthly averages of atmospheric Methane for atmospheric species. Data are provided at 2 degree latitude X 4 degree longitude...

  11. HIRDLS/Aura Level 3 Nitrogen Dioxide (NO2) Zonal Fourier Coefficients V007

    Data.gov (United States)

    National Aeronautics and Space Administration — The "HIRDLS/Aura Level 3 Nitrogen Dioxide (NO2) Zonal Fourier Coefficients" version 7 data product (H3ZFCNO2) contains the entire mission (~3 years) of HIRDLS data...

  12. HIRDLS/Aura Level 3 Chlorofluorocarbon-12 (CFC-12) Zonal Fourier Coefficients V007

    Data.gov (United States)

    National Aeronautics and Space Administration — The "HIRDLS/Aura Level 3 Chlorofluorocarbon-12 (CFC-12) Zonal Fourier Coefficients" version 7 data product (H3ZFCCFC12) contains the entire mission (~3 years) of...

  13. HIRDLS/Aura Level 3 Nitrous Oxide (N2O) Zonal Fourier Coefficients V007

    Data.gov (United States)

    National Aeronautics and Space Administration — The "HIRDLS/Aura Level 3 Nitrous Oxide (N2O) Zonal Fourier Coefficients" version 7 data product (H3ZFCN2O) contains the entire mission (~3 years) of HIRDLS data...

  14. HIRDLS/Aura Level 3 Extinction at 12.1 Microns Zonal Fourier Coefficients V007

    Data.gov (United States)

    National Aeronautics and Space Administration — The "HIRDLS/Aura Level 3 Extinction at 12.1 Microns Zonal Fourier Coefficients" version 7 data product (H3ZFC12MEXT) contains the entire mission (~3 years) of HIRDLS...

  15. HIRDLS/Aura Level 3 Extinction at 8.3 Microns Zonal Fourier Coefficients V007

    Data.gov (United States)

    National Aeronautics and Space Administration — The "HIRDLS/Aura Level 3 Extinction at 8.3 Microns Zonal Fourier Coefficients" version 7 data product (H3ZFC8MEXT) contains the entire mission (~3 years) of HIRDLS...

  16. HIRDLS/Aura Level 3 Chlorine Nitrate (ClONO2) Zonal Fourier Coefficients V007

    Data.gov (United States)

    National Aeronautics and Space Administration — The "HIRDLS/Aura Level 3 Chlorine Nitrate (ClONO2) Zonal Fourier Coefficients" version 7 data product (H3ZFCCLONO2) contains the entire mission (~3 years) of HIRDLS...

  17. MLS/Aura Level 2 Methyl Cyanide (CH3CN) Mixing Ratio V004

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2CH3CN is the EOS Aura Microwave Limb Sounder (MLS) standard product for methyl cyanide derived from radiances measured by the 640 GHz radiometer. The current...

  18. MLS/Aura L2 Methyl Cyanide (CH3CN) Mixing Ratio V003

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2CH3CN is the EOS Aura Microwave Limb Sounder (MLS) standard product for methyl cyanide derived from radiances measured by the 640 GHz radiometer. The current...

  19. TES/Aura L3 CO2 Daily Gridded V004

    Data.gov (United States)

    National Aeronautics and Space Administration — The TES Aura L3 CO2 data consist of daily atmospheric temperature and VMR for the atmospheric species. Data are provided at 2 degree latitude X 4 degree longitude...

  20. TES/Aura L3 HNO3 Monthly Gridded V004

    Data.gov (United States)

    National Aeronautics and Space Administration — The TES Aura L3 ATD data consist of monthly atmospheric temperature and VMR for the atmospheric species. Data are provided at 2 degree latitude X 4 degree longitude...

  1. MLS/Aura L2 Relative Humidity With Respect To Ice V002

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2RHI is the EOS Aura Microwave Limb Sounder (MLS) standard product for relative humidity with respect to ice derived from radiances measured by the 118 and 190 GHz...

  2. MLS/Aura L1 Radiances from Digital Autocorrelators V004

    Data.gov (United States)

    National Aeronautics and Space Administration — ML1RADD is the EOS Aura Microwave Limb Sounder (MLS) product containing the level 1 radiances from the digital autocorrelators. The current version is 4.2. Data...

  3. MLS/Aura L2 Hydroxyl (OH) Mixing Ratio V003

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2OH is the EOS Aura Microwave Limb Sounder (MLS) standard product for hydroxyl derived from radiances measured by the THz radiometer. The current version is...

  4. MLS/Aura Level 2 Hydrogen Cyanide (HCN) Mixing Ratio V004

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2HCN is the EOS Aura Microwave Limb Sounder (MLS) standard product for hydrogen cyanide derived from radiances measured primarily by the 190 GHz radiometer. The...

  5. MLS/Aura L1 Radiances from Filter Banks for GHz V003

    Data.gov (United States)

    National Aeronautics and Space Administration — ML1RADG is the EOS Aura Microwave Limb Sounder (MLS) product containing the level 1 radiances from the filter banks for the GHz radiometers. The current version is...

  6. HIRDLS/Aura Level 2 Geophysical Parameters (on a pressure grid) V007

    Data.gov (United States)

    National Aeronautics and Space Administration — The "HIRDLS/Aura Level 2 Geophysical Parameters" data product (HIRDLS2) contains an entire day's worth of Level-2 vertical profiles of O3, HNO3, H2O, CFC-11, CFC-12,...

  7. MLS/Aura L2 Carbon Monoxide (CO) Mixing Ratio V003

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2CO is the EOS Aura Microwave Limb Sounder (MLS) standard product for carbon monoxide derived from radiances measured by the 640 GHz radiometer. The current...

  8. MLS/Aura L2 Water Vapor (H2O) Mixing Ratio V003

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2H2O is the EOS Aura Microwave Limb Sounder (MLS) standard product for water vapor derived from radiances measured primarily by the 190 GHz radiometer. The current...

  9. MLS/Aura L1 Radiances from Filter Banks for THz V003

    Data.gov (United States)

    National Aeronautics and Space Administration — ML1RADT is the EOS Aura Microwave Limb Sounder (MLS) product containing the level 1 radiances from the filter banks for the THz radiometer. The current version is...

  10. Earth Observing System (EOS) Aqua and Aura Space Weather Effects on Operational Collision Avoidance

    Science.gov (United States)

    Guit, Bill

    2017-01-01

    This presentation will describe recent EOS Aqua and Aura operational collision avoidance experience during periods of solar and geomagnetic storm activity. It will highlight challenges faced by the operations team during short-notice, high-risk predicted close approaches. The presentation will highlight the evolution of the operational collision avoidance process for the EOS Aqua and Aura missions. The presentation will highlight operational challenges that have occurred, process improvements that have been implemented and identify potential future challenges.

  11. A cellular Potts model of germband retraction and dorsal closure

    Science.gov (United States)

    Hutson, M. Shane; Rohner, Jason; Crews, Sarah; McCleery, W. Tyler; Robinson, W. Bradley

    2011-03-01

    Germband retraction and dorsal closure are critical morphogenetic events in fruit fly embryogenesis. Both involve the coordinated reshaping of two epitheloid tissues -- germband (GB) and amnioserosa (AS). The GB is initially curled into a U-shape with the AS between the arms of the U. Retraction leaves the embryo's dorsal surface covered by AS cells which then contract to pull lateral parts of the GB up to cover the dorsal surface. We have simulated these events using a cellular Potts model. The model is 3D with several generalized cell types: a central yolk; a surrounding monolayer of AS and GB cells with epithelial polarization; and an outer vitelline membrane enclosing the cells and a perivitelline fluid. The model also incorporates several critical cell behaviors: polarized apical constriction of AS cells; controlled relaxation of stretched GB cells; and differentiation of GB cells at the GB-AS interface so that these cells then contract a supracellular purse-string and extend filopodia that reach across the AS and zip together the GB's approaching lateral flanks. We will discuss how all of these components are necessary to reproduce normal tissue motions and those observed during laser microsurgery experiments. Supported by NSF Grant IOB-0545679.

  12. Surgical effects in patients with Duane retraction syndrome

    Directory of Open Access Journals (Sweden)

    Shui-Lian Zhou

    2017-03-01

    Full Text Available AIM: To investigate the clinical characteristics and surgical effects in patients with Duane retraction syndrome(DRS.METHODS: Totally 13 patients with DRS during June 2011 to December 2015 were analyzed retrospectively. The data including clinical types and manifestations, surgical methods and outcomes were reviewed and analyzed. RESULTS: There were 11 male cases and 2 female cases who all had no ocular and systemic anomalies. The left eye was involved in 9 cases, the right eye was involved in 3 cases and 1 case involved in both eyes. Six cases were type Ⅰ,1 case was typeⅡand 6 cases were type Ⅲ. Eleven cases had abnormal head posture(AHP, 9 cases had the up- or down-shoot phenomenon. The surgical treatment was designed according to subtypes and clinical features which included medial rectus recession, lateral rectus recession, recession of both horizontal rectus muscles and lateral rectus recession combined with Y splitting. After surgery, horizontal deviation was less than ±10△ in all patients, and AHP disappeared in 4 cases and improved in 7 cases. The up- or down-shoot and global retraction disappeared in 5 cases and improved in 4 cases. Simultaneously, the restriction of ocular motility was improved in all patients. CONCLUSION: The clinical features of DRS are variant in different types. Detailed examination before surgery and reasonable surgical design are important in treatment of patients with DRS.

  13. Frequency of pediatric migraine with aura in a clinic-based sample.

    Science.gov (United States)

    Genizi, Jacob; Khourieh Matar, Amal; Zelnik, Nathanel; Schertz, Mitchell; Srugo, Isaac

    2016-01-01

    To assess the prevalence and risk factors for pediatric migraine with aura (MWA) among patients presenting to pediatric neurology clinics. Headache is a common complaint among children, and the prevalence of migraine is about 8%. Up to one third of adults with migraine report experiencing aura; however, the exact percentage in children is unknown. Medical records of children presenting with headache to three pediatric neurology clinics in Haifa in the last 5 years were retrospectively reviewed. Inclusion criteria were a diagnosis of migraine headache at 5-18 years of age. Of 260 children (140 female) who had migraine, 26.2% experienced aura. MWA was more common among females compared to males (32.6% vs 18.9%, P aura, visual aura was more common in females than males (66.7% vs 33.3%, P Aura is more common in older children. Children who have MWA are more likely to have a family history of migraine. © 2015 American Headache Society.

  14. The epileptic aura in literature: aesthetic and philosophical dimensions. An essay.

    Science.gov (United States)

    Wolf, Peter

    2013-03-01

    In literary accounts of epilepsy the aura has a prominent place as the subjective aspect of the seizure experience. Descriptions by authors with their own aura experiences stand out by their precision and authenticity. Many different aura types are mentioned, but the ecstatic aura described by Dostoyevsky has received particular attention and is echoed in many later works. Some authors are interested primarily in the possibilities provided by auras to react, for example, by hiding, seeking help, counteracting the oncoming seizure, or taking measures to prevent damage. Others by their unique aura experiences are inspired to create specific literary flavors like oxymora, spectacular metaphors, or the depiction of complex perceptions and states of mind. Some authors, adding a philosophical dimension, proceed to analyze the consequences of patients' subjective seizure experiences for their identity and their self-perception as creative or religious persons. To sum up, the works discussed herein strongly support that literary texts provide valuable insights beyond those of medical texts. Wiley Periodicals, Inc. © 2013 International League Against Epilepsy.

  15. A Decade of Volcanic Observations from Aura and the A-Train

    Science.gov (United States)

    Carn, Simon A.; Krotkov, Nickolay Anatoly; Yang, Kai; Krueger, Arlin J.; Hughes, Eric J.; Wang, Jun; Flower, Verity; Telling, Jennifer

    2014-01-01

    Aura observations have made many seminal contributions to volcanology. Prior to the Aura launch, satellite observations of volcanic degassing (e.g., from TOMS) were mostly restricted to large eruptions. However, the vast majority of volcanic gases are released during quiescent 'passive' degassing between eruptions. The improved sensitivity of Aura OMI permitted the first daily, space-borne measurements of passive volcanic SO2 degassing, providing improved constraints on the source locations and magnitude of global SO2 emissions for input to atmospheric chemistry and climate models. As a result of this unique sensitivity to volcanic activity, OMI data were also the first satellite SO2 measurements to be routinely used for volcano monitoring at several volcano observatories worldwide. Furthermore, the Aura OMI SO2 data also offer unprecedented sensitivity to volcanic clouds in the UTLS, elucidating the transport, fate and lifetime of volcanic SO2 and providing critical input to aviation hazard mitigation efforts. Another major advance has been the improved vertical resolution of volcanic clouds made possible by synergy between Aura and other A-Train instruments (e.g., AIRS, CALIPSO, CloudSat), advanced UV SO2 altitude retrievals, and inverse trajectory modeling of detailed SO2 cloud maps. This altitude information is crucial for climate models and aviation hazards. We will review some of the highlights of a decade of Aura observations of volcanic activity and look ahead to the future of volcanic observations from space.

  16. 14 CFR 23.729 - Landing gear extension and retraction system.

    Science.gov (United States)

    2010-01-01

    ... use of hydraulic pressure) to keep the landing gear extended. (c) Emergency operation. For a landplane... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Landing gear extension and retraction... Design and Construction Landing Gear § 23.729 Landing gear extension and retraction system. (a) General...

  17. When Scholarly Publishing Goes Awry: Educating Ourselves and Our Patrons about Retracted Articles

    Science.gov (United States)

    Thielen, Joanna

    2018-01-01

    Retracted articles, articles that violate professional ethics, are an unsettling, yet integral, part of the scholarly publishing process seldom discussed in the academy. Unfortunately, article retractions continue to rise across all disciplines. Although academic librarians consistently provide instruction on scholarly publishing, little has been…

  18. Retracted: The clinical anatomy of the insertion of the rotator cuff ...

    African Journals Online (AJOL)

    2nd March 2017 - Article Retracted. The Article THE CLINICAL ANATOMY OF THE INSERTION OF THE ROTATOR CUFF TENDON has been retracted from the Anatomy Journal of Africa on author request, and on the understanding that it was concurrently submitted and published in another journal. Managing Editor.

  19. 76 FR 472 - Harmonization of Airworthiness Standards for Transport Category Airplanes-Landing Gear Retracting...

    Science.gov (United States)

    2011-01-05

    ... Airworthiness Standards for Transport Category Airplanes--Landing Gear Retracting Mechanisms and Pilot... transport category airplanes on landing gear retracting mechanisms and the pilot compartment view. This... in a stalling maneuver, and would add an additional requirement to keep the landing gear and doors in...

  20. Interhemispheric differences of fMRI responses to visual stimuli in patients with side-fixed migraine aura

    DEFF Research Database (Denmark)

    Hougaard, Anders; Amin, Faisal Mohammad; Hoffmann, Michael B

    2014-01-01

    Migraine sufferers with aura often report photosensitivity and visual discomfort outside of attacks and many consider bright or flickering light an attack-precipitating factor. The nature of this visual hypersensitivity and its relation to the underlying pathophysiology of the migraine aura...... is unknown. Using fMRI measurements during visual stimulation we examined the visual cortical responsiveness of patients with migraine with aura. We applied a within-patient design by assessing functional interhemispheric differences in patients consistently experiencing visual aura in the same visual...... hemifield. We recruited 20 patients with frequent side-fixed visual aura attacks (≥90% of auras occurring in the same visual hemifield) and 20 age and sex matched healthy controls and compared the fMRI blood oxygenation level dependent (BOLD) responses to visual stimulation between symptomatic...

  1. Correlation Between Cerebellar Retraction and Hearing Loss After Microvascular Decompression for Hemifacial Spasm: A Prospective Study.

    Science.gov (United States)

    Li, Ning; Zhao, Wei-Guo; Pu, Chun-Hua; Yang, Wen-Lei

    2017-06-01

    This study prospectively investigated the relationship between cerebellar retraction factors measured on preoperative magnetic resonance and the development of postoperative hearing loss and evaluated their potential role in predicting the possibility of hearing loss after microvascular decompression (MVD) for hemifacial spasm (HFS). The study included 110 patients clinically diagnosed with primary HFS who underwent MVD in our department. The cerebellar retraction factors were quantitatively measured on preoperative magnetic resonance. Associations of cerebellar retraction and other risk factors with postoperative hearing loss were analyzed. Eleven patients (10%) developed nonserviceable hearing loss after MVD. Compared with the group without hearing loss, the cerebellar retraction distance and depth of the group with hearing loss were significantly greater (P hearing loss (P hearing loss after MVD for HFS. In addition, cerebellar retraction depth could be considered as a useful tool to predict the risk of post-MVD hearing loss. Copyright © 2017 Elsevier Inc. All rights reserved.

  2. Retractions in general and internal medicine in a high-profile scientific indexing database

    Directory of Open Access Journals (Sweden)

    Renan Moritz Varnier Rodrigues de Almeida

    Full Text Available CONTEXT AND OBJECTIVE: Increased frequency of retractions has recently been observed, and retractions are important events that deserve scientific investigation. This study aimed to characterize cases of retraction within general and internal medicine in a high-profile database, with interest in the country of origin of the article and the impact factor (IF of the journal in which the retraction was made. DESIGN AND SETTING: This study consisted of reviewing retraction notes in the Thomson-Reuters Web of Knowledge (WoK indexing database, within general and internal medicine. METHODS: The retractions were classified as plagiarism/duplication, error, fraud and authorship problems and then aggregated into two categories: "plagiarism/duplication" and "others." The countries of origin of the articles were dichotomized according to the median of the indicator "citations per paper" (CPP, and the IF was dichotomized according to its median within general and internal medicine, also obtained from the WoK database. These variables were analyzed using contingency tables according to CPP (high versus low, IF (high versus low and period (1992-2002 versus 2003-2014. The relative risk (RR and 95% confidence interval (CI were estimated for plagiarism/duplication. RESULTS: A total of 86 retraction notes were identified, and retraction reasons were found for 80 of them. The probability that plagiarism/duplication was the reason for retraction was more than three times higher for the low CPP group (RR: 3.4; 95% CI: [1.9-6.2], and similar results were seen for the IF analysis. CONCLUSION: The study identified greater incidence of plagiarism/duplication among retractions from countries with lower scientific impact.

  3. Retractions in general and internal medicine in a high-profile scientific indexing database.

    Science.gov (United States)

    de Almeida, Renan Moritz Varnier Rodrigues; Catelani, Fernanda; Fontes-Pereira, Aldo José; Gave, Nárrima de Souza

    2016-01-01

    Increased frequency of retractions has recently been observed, and retractions are important events that deserve scientific investigation. This study aimed to characterize cases of retraction within general and internal medicine in a high-profile database, with interest in the country of origin of the article and the impact factor (IF) of the journal in which the retraction was made. This study consisted of reviewing retraction notes in the Thomson-Reuters Web of Knowledge (WoK) indexing database, within general and internal medicine. The retractions were classified as plagiarism/duplication, error, fraud and authorship problems and then aggregated into two categories: "plagiarism/duplication" and "others." The countries of origin of the articles were dichotomized according to the median of the indicator "citations per paper" (CPP), and the IF was dichotomized according to its median within general and internal medicine, also obtained from the WoK database. These variables were analyzed using contingency tables according to CPP (high versus low), IF (high versus low) and period (1992-2002 versus 2003-2014). The relative risk (RR) and 95% confidence interval (CI) were estimated for plagiarism/duplication. A total of 86 retraction notes were identified, and retraction reasons were found for 80 of them. The probability that plagiarism/duplication was the reason for retraction was more than three times higher for the low CPP group (RR: 3.4; 95% CI: [1.9-6.2]), and similar results were seen for the IF analysis. The study identified greater incidence of plagiarism/duplication among retractions from countries with lower scientific impact.

  4. Increased brainstem perfusion, but no blood-brain barrier disruption, during attacks of migraine with aura.

    Science.gov (United States)

    Hougaard, Anders; Amin, Faisal M; Christensen, Casper E; Younis, Samaira; Wolfram, Frauke; Cramer, Stig P; Larsson, Henrik B W; Ashina, Messoud

    2017-06-01

    See Moskowitz (doi:10.1093/brain/awx099) for a scientific commentary on this article.The migraine aura is characterized by transient focal cortical disturbances causing dramatic neurological symptoms that are usually followed by migraine headache. It is currently not understood how the aura symptoms are related to the headache phase of migraine. Animal studies suggest that cortical spreading depression, the likely mechanism of migraine aura, causes disruption of the blood-brain barrier and noxious stimulation of trigeminal afferents leading to activation of brainstem nuclei and triggering of migraine headache. We used the sensitive and validated technique of dynamic contrast-enhanced high-field magnetic resonance imaging to simultaneously investigate blood-brain barrier permeability and tissue perfusion in the brainstem (at the level of the lower pons), visual cortex, and brain areas of the anterior, middle and posterior circulation during spontaneous attacks of migraine with aura. Patients reported to our institution to undergo magnetic resonance imaging during the headache phase after presenting with typical visual aura. Nineteen patients were scanned during attacks and on an attack-free day. The mean time from attack onset to scanning was 7.6 h. We found increased brainstem perfusion bilaterally during migraine with aura attacks. Perfusion also increased in the visual cortex and posterior white matter following migraine aura. We found no increase in blood-brain barrier permeability in any of the investigated regions. There was no correlation between blood-brain barrier permeability, brain perfusion, and time from symptom onset to examination or pain intensity. Our findings demonstrate hyperperfusion in brainstem during the headache phase of migraine with aura, while the blood-brain barrier remains intact during attacks of migraine with aura. These data thus contradict the preclinical hypothesis of cortical spreading depression-induced blood-brain barrier

  5. Numerical study of the stopping of aura during migraine

    Directory of Open Access Journals (Sweden)

    Moussa A.

    2010-12-01

    Full Text Available This work is devoted to the study of migraine with aura in the human brain. Following [6], we class migraine as a propagation of a wave of depolarization through the cells. The mathematical model used, based on a reaction-diffusion equation, is briefly presented. The equation is considered in a duct containing a bend, in order to model one of the numerous circumvolutions of the brain. For a wide set of parameters, one can establish the existence of a critical radius below which the wave stops. The approximation scheme used for the simulations is first described and then a numerical study is realized, precising the dependence of the critical radius with respect to the different parameters of the model. Ce travail est consacré à l’étude de l’évolution d’une migraine avec aura dans le cerveau humain. Suivant [6], nous assimilons la migraine à une onde de dépolarisation attaquant les cellules du cerveau. Le modèle mathématique retenu, basé sur une équation de réaction-diffusion, est brièvement rappelé. Le domaine d’espace utilisé est constitué d’un conduit présentant un coude, afin de représenter l’une des nombreuses circonvolutions cérébrales. Pour une importante classe de paramètres, il est possible de mettre en évidence l’existence d’un rayon critique au delà duquel le front d’onde n’arrive pas à dépasser le coude. Après une description du schéma d’approximation utilisé, une étude numérique a été réalisée, visant à préciser la dépendance du rayon critique en fonction des différents paramètres du modèle.

  6. Atypical association of Duane retraction syndrome and Bardet Biedl syndrome

    Directory of Open Access Journals (Sweden)

    Jethani Jitendra

    2007-01-01

    Full Text Available Duane′s retraction syndrome (DRS includes changes in palpebral fissure width along with restriction of ocular motility. Bardet Biedl syndrome (BBS includes presence of retinitis pigmentosa (RP with obesity, mental retardation, polydactyly and renal abnormalities. We report a case of rare association of DRS with BBS in a seven-year-old child. The ocular motility examination revealed left DRS with esotropia. Fundus examination revealed findings characteristic of an atypical retinitis pigmentosa. The electro-retinogram waveforms were extinguished both for rods and cones. He was diagnosed as a case of BBS on the basis of the ophthalmological findings plus association with the systemic features of obesity, polydactyly, hypogonadism, mental retardation and renal abnormalities. This case gives further evidence of the fact that BBS may be associated with abnormalities of eye movements.

  7. Increased intrinsic brain connectivity between pons and somatosensory cortex during attacks of migraine with aura.

    Science.gov (United States)

    Hougaard, Anders; Amin, Faisal Mohammad; Larsson, Henrik B W; Rostrup, Egill; Ashina, Messoud

    2017-05-01

    The neurological disturbances of migraine aura are caused by transient cortical dysfunction due to waves of spreading depolarization that disrupt neuronal signaling. The effects of these cortical events on intrinsic brain connectivity during attacks of migraine aura have not previously been investigated. Studies of spontaneous migraine attacks are notoriously challenging due to their unpredictable nature and patient discomfort. We investigated 16 migraine patients with visual aura during attacks and in the attack-free state using resting state fMRI. We applied a hypothesis-driven seed-based approach focusing on cortical visual areas and areas involved in migraine pain, and a data-driven independent component analysis approach to detect changes in intrinsic brain signaling during attacks. In addition, we performed the analyses after mirroring the MRI data according to the side of perceived aura symptoms. We found a marked increase in connectivity during attacks between the left pons and the left primary somatosensory cortex including the head and face somatotopic areas (peak voxel: P = 0.0096, (x, y, z) = (-54, -32, 32), corresponding well with the majority of patients reporting right-sided pain. For aura-side normalized data, we found increased connectivity during attacks between visual area V5 and the lower middle frontal gyrus in the symptomatic hemisphere (peak voxel: P = 0.0194, (x, y, z) = (40, 40, 12). The present study provides evidence of altered intrinsic brain connectivity during attacks of migraine with aura, which may reflect consequences of cortical spreading depression, suggesting a link between aura and headache mechanisms. Hum Brain Mapp 38:2635-2642, 2017. © 2017 Wiley Periodicals, Inc. © 2017 Wiley Periodicals, Inc.

  8. No abnormalities of intrinsic brain connectivity in the interictal phase of migraine with aura.

    Science.gov (United States)

    Hougaard, A; Amin, F M; Magon, S; Sprenger, T; Rostrup, E; Ashina, M

    2015-04-01

    Functional neuroimaging studies have shown hyperresponsiveness of cortical areas to visual stimuli in migraine patients with aura outside of attacks. This may be a key feature in the initiation of aura episodes and possibly also migraine headache attacks. It is unknown if cortical dysfunction is present at rest, i.e. in the absence of any external stimuli. Functional magnetic resonance imaging is a powerful technique for evaluating resting state functional connectivity, i.e. coherence of brain activity across cerebral areas. The objective of this study was to investigate resting-state functional brain connectivity in migraineurs with aura outside of attacks using functional magnetic resonance imaging. Forty patients suffering from migraine with visual aura and 40 individually age and gender matched healthy controls with no history or family history of migraine were investigated. Following advanced denoising, the data were analyzed both in a hypothesis-driven fashion, testing for abnormalities involving 27 different brain areas of potential relevance to migraine with aura including the cortical visual areas, the amygdala and peri-aqueductal grey matter, and in a data-driven exploratory fashion (dual regression) in order to reveal any possible between-group differences of resting state networks. Age, gender, attack frequency and disease duration were included as nuisance variables. No differences of functional connectivity were found between patients and controls. The previously reported increased cortical hyperresponsivity in the interictal phase of migraine with aura is unlikely to be caused by abnormalities of intrinsic brain connectivity. The interictal migraine aura brain may be abnormally functioning only during exposure to external stimuli. © 2015 EAN.

  9. Tapio Aura - tsemenditehas tuleb järgmisele põlvkonnale üle anda natuke paremas seisus / Tapio Aura ; interv. Toomas Kään

    Index Scriptorium Estoniae

    Aura, Tapio

    2005-01-01

    AS Kunda Nordic Tsement juhatuse esimees on kümne Eestis elatud ja töötatud aastaga ära õppinud eesti keele ning teinud tehasest tugeva, jätkusuutliku ja konkurentsivõimelise ettevõtte. Lisa: Eino Tapio Aura. Kommenteerib maxit Estonia AS tegevdirektor Viktor Valkiainen

  10. [ISOMETRIC RETRACTION AND THE INVISIBLE PROCESSES OF NERVE CELLS].

    Science.gov (United States)

    Sotnikov, O S; Vasyagina, N Yu; Krasnova, T V

    2015-01-01

    Recently, a large number of physiological studies on stress and hibernation had described an unusual morphological phenomenon of the rapid disappearance and reapperance of apical dendrites of pyramidal neurons of the hippocampus, prefrontal cortex and other parts of the brain. In this article an attempt is maid to explain this phenomenon on the basis of morphological analysis of natural elastic properties of neuroplasm and structural kinetics of partially preserved processes of the living isolated neurons. The neuroplasm displacement with its bidirectional flow was identified in the processes. A new physiological phenomenon is described--the isometric retraction of nerve cell processes, during which the neuroplasm fluxes were directed to the opposite sides, leading to abrupt thinning of middle parts of the processes and to a thickening of both ends. It is suggested that the extremely attenuated processes can reach the submicroscopic sizes, becoming invisible in the light microscope. The repeated reversible "disappearance" and "appearance" of the processes was demonstrated supravitally in the culture of neurons and of C-1300 neuroblastoma cells. Reduction of the diameter of the processes to a limit of their visibility was demonstrated by the example of their natural stretching. The same effect was observed in the areas between the reversible varicosities of the processes. These areas became extremely thin, and then invisible. Becoming thinner, the processes were capable of sharp extension. A review of the available literature and our own data allow to conclude that the phenomenon of the disappearance of the apical dendrites was due to their isometric retraction, which lead to the emergence of "invisible processes".

  11. Excitable actin dynamics in lamellipodial protrusion and retraction.

    Science.gov (United States)

    Ryan, Gillian L; Petroccia, Heather M; Watanabe, Naoki; Vavylonis, Dimitrios

    2012-04-04

    Many animal cells initiate crawling by protruding lamellipodia, consisting of a dense network of actin filaments, at their leading edge. We imaged XTC cells that exhibit flat lamellipodia on poly-L-lysine-coated coverslips. Using active contours, we tracked the leading edge and measured the total amount of F-actin by summing the pixel intensities within a 5-μm band. We observed protrusion and retraction with period 130-200 s and local wavelike features. Positive (negative) velocities correlated with minimum (maximum) integrated actin concentration. Approximately constant retrograde flow indicated that protrusions and retractions were driven by fluctuations of the actin polymerization rate. We present a model of these actin dynamics as an excitable system in which a diffusive, autocatalytic activator causes actin polymerization; F-actin accumulation in turn inhibits further activator accumulation. Simulations of the model reproduced the pattern of actin polymerization seen in experiments. To explore the model's assumption of an autocatalytic activation mechanism, we imaged cells expressing markers for both F-actin and the p21 subunit of the Arp2/3 complex. We found that integrated Arp2/3-complex concentrations spike several seconds before spikes of F-actin concentration. This suggests that the Arp2/3 complex participates in an activation mechanism that includes additional diffuse components. Response of cells to stimulation by fetal calf serum could be reproduced by the model, further supporting the proposed dynamical picture. Copyright © 2012 Biophysical Society. Published by Elsevier Inc. All rights reserved.

  12. Observational Diagnoses of Extratropical Ozone STE During the Aura Era

    Science.gov (United States)

    Olsen, Mark A.; Douglass, Anne R.; Witte, Jacquie C.; Kaplan, Trevor B.

    2011-01-01

    The transport of ozone from the stratosphere to the extratropical troposphere is an important boundary condition to tropospheric chemistry. However, previous direct estimates from models and indirect estimates from observations have poorly constrained the magnitude of ozone stratosphere-troposphere exchange (STE). In this study we provide a direct diagnosis of the extratropical ozone STE using data from the Microwave Limb Sounder on Aura and output of the MERRA reanalysis over the time period from 2005 to the present. We find that the mean annual STE is about 275 Tg/yr and 205 Tg/yr in the NH and SH, respectively. The interannual variability of the magnitude is about twice as great in the NH than the SH. We find that this variability is dominated by the seasonal variability during the late winter and spring. A comparison of the ozone flux to the mass flux reveals that there is not a simple relationship between the two quantities. This presentation will also examine the magnitude and distribution of ozone in the lower stratosphere relative to the years of maximum and minimum ozone STE. Finally, we will examine any possible signature of increased ozone STE in the troposphere using sonde and tropospheric ozone residual (TOR) data, and output from the Global Modeling Initiative Chemistry Transport Model (GMI CTM).

  13. Observations of volcanic SO2 from MLS on Aura

    Directory of Open Access Journals (Sweden)

    H. C. Pumphrey

    2015-01-01

    Full Text Available Sulfur dioxide (SO2 is an important atmospheric constituent, particularly in the aftermath of volcanic eruptions. These events can inject large amounts of SO2 into the lower stratosphere, where it is oxidised to form sulfate aerosols; these in turn have a significant effect on the climate. The MLS instrument on the Aura satellite has observed the SO2 mixing ratio in the upper troposphere and lower stratosphere from August 2004 to the present, during which time a number of volcanic eruptions have significantly affected those regions of the atmosphere. We describe the MLS SO2 data and how various volcanic events appear in the data. As the MLS SO2 data are currently not validated we take some initial steps towards their validation. First we establish the level of internal consistency between the three spectral regions in which MLS is sensitive to SO2. We compare SO2 column values calculated from MLS data to total column values reported by the OMI instrument. The agreement is good (within about 1 DU in cases where the SO2 is clearly at altitudes above 147 hPa.

  14. Características clínicas da enxaqueca sem aura Clinical characteristics of migraine without aura

    Directory of Open Access Journals (Sweden)

    LUIZ PAULO DE QUEIROZ

    1998-03-01

    Full Text Available Um estudo aprofundado das características clínicas da enxaqueca sem aura (ESA revela alguns dados interessantes. Um questionário foi respondido por 200 pacientes que preenchiam os critérios da Sociedade Internacional de Cefaléia para ESA. O pico do início da enxaqueca foi entre 10 e 19 anos de idade. A cefaléia era restrita a um lado em 19%. Era exclusivamente bilateral em 9%. A maioria (86,2% dos pacientes que descreveram cefaléias em um único local localizou-a na área fronto-temporal. Cervicalgia estava associada aos ataques de enxaqueca em 70,5% e dor facial em 73,5%. O caráter latejante foi notado por 81%. Todos os pacientes descreveram a cefaléia como moderada a severa. Somente 55% disseram que a dor era agravada por atividades físicas rotineiras. Náusea ocorreu em 91%, foto e fonofobia em 77% e vômitos em 50%. Este olhar detalhado na ESA demonstra a grande complexidade dos seus sintomas.A detailed study of the clinical characteristics of migraine without aura (MOA reveals some interesting data. A questionnaire was returned by 200 patients who met the International Headache Society criteria for MOA. The peak of onset of migraine was between 10 and 19 years of age. The headache was side-locked in 19%. It was exclusively bilateral in 9%. The majority (86.2% of the patients who described headaches in only one site located them in the fronto-temporal area. Neck pain was associated with migraine attacks in 70.5% and face pain in 73.5%. A pounding quality was noted by 81%. Every patient described the headache as moderate to severe. Only 55% stated that it was aggravated by routine physical activity. Nausea occurred in 91%, photo and phonophobia in 77%, and vomiting in 50%. This close look at MOA uncovers a great complexity of symptoms.

  15. Effectiveness of en masse versus two-step retraction: a systematic review and meta-analysis

    Directory of Open Access Journals (Sweden)

    Mumen Z. Rizk

    2018-01-01

    Full Text Available Abstract Background This review aims to compare the effectiveness of en masse and two-step retraction methods during orthodontic space closure regarding anchorage preservation and anterior segment retraction and to assess their effect on the duration of treatment and root resorption. Methods An electronic search for potentially eligible randomized controlled trials and prospective controlled trials was performed in five electronic databases up to July 2017. The process of study selection, data extraction, and quality assessment was performed by two reviewers independently. A narrative review is presented in addition to a quantitative synthesis of the pooled results where possible. The Cochrane risk of bias tool and the Newcastle-Ottawa Scale were used for the methodological quality assessment of the included studies. Results Eight studies were included in the qualitative synthesis in this review. Four studies were included in the quantitative synthesis. En masse/miniscrew combination showed a statistically significant standard mean difference regarding anchorage preservation − 2.55 mm (95% CI − 2.99 to − 2.11 and the amount of upper incisor retraction − 0.38 mm (95% CI − 0.70 to − 0.06 when compared to a two-step/conventional anchorage combination. Qualitative synthesis suggested that en masse retraction requires less time than two-step retraction with no difference in the amount of root resorption. Conclusions Both en masse and two-step retraction methods are effective during the space closure phase. The en masse/miniscrew combination is superior to the two-step/conventional anchorage combination with regard to anchorage preservation and amount of retraction. Limited evidence suggests that anchorage reinforcement with a headgear produces similar results with both retraction methods. Limited evidence also suggests that en masse retraction may require less time and that no significant differences exist in the amount of root

  16. Effectiveness of en masse versus two-step retraction: a systematic review and meta-analysis.

    Science.gov (United States)

    Rizk, Mumen Z; Mohammed, Hisham; Ismael, Omar; Bearn, David R

    2018-01-05

    This review aims to compare the effectiveness of en masse and two-step retraction methods during orthodontic space closure regarding anchorage preservation and anterior segment retraction and to assess their effect on the duration of treatment and root resorption. An electronic search for potentially eligible randomized controlled trials and prospective controlled trials was performed in five electronic databases up to July 2017. The process of study selection, data extraction, and quality assessment was performed by two reviewers independently. A narrative review is presented in addition to a quantitative synthesis of the pooled results where possible. The Cochrane risk of bias tool and the Newcastle-Ottawa Scale were used for the methodological quality assessment of the included studies. Eight studies were included in the qualitative synthesis in this review. Four studies were included in the quantitative synthesis. En masse/miniscrew combination showed a statistically significant standard mean difference regarding anchorage preservation - 2.55 mm (95% CI - 2.99 to - 2.11) and the amount of upper incisor retraction - 0.38 mm (95% CI - 0.70 to - 0.06) when compared to a two-step/conventional anchorage combination. Qualitative synthesis suggested that en masse retraction requires less time than two-step retraction with no difference in the amount of root resorption. Both en masse and two-step retraction methods are effective during the space closure phase. The en masse/miniscrew combination is superior to the two-step/conventional anchorage combination with regard to anchorage preservation and amount of retraction. Limited evidence suggests that anchorage reinforcement with a headgear produces similar results with both retraction methods. Limited evidence also suggests that en masse retraction may require less time and that no significant differences exist in the amount of root resorption between the two methods.

  17. OMI/Aura DOAS Total Column Ozone 1-Orbit L2 Swath 13x24 km V003 (OMDOAO3) at GES DISC

    Data.gov (United States)

    National Aeronautics and Space Administration — The second release of Aura Ozone Monitoring Instrument (OMI) Version 003 OMI/Aura Level-2 Total Column Ozone Data Product OMDOAO3 is now available from the NASA...

  18. OMI/Aura Bromine Monoxide (BrO) Total Column 1-orbit L2 Swath 13x24 km V003 (OMBRO) at GES DISC

    Data.gov (United States)

    National Aeronautics and Space Administration — The Aura Ozone Monitoring Instrument (OMI) collection-3 Bromine Monoxide Product OMBRO from the Aura-OMI, is now available from the NASA Goddard Earth Sciences Data...

  19. OMI/Aura Chlorine Dioxide (OClO) Total Column 1-orbit L2 Swath 13x24 km V003

    Data.gov (United States)

    National Aeronautics and Space Administration — The collection-3 Chlorine Dioxide Product OMOCLO from the Aura-OMI, is now available (http://disc.gsfc.nasa.gov/Aura/OMI/omoclo_v003.shtml) from the NASA Goddard...

  20. OMI/Aura Bromine Monoxide (BrO) Total Column 1-orbit L2 Swath 13x24 km V003

    Data.gov (United States)

    National Aeronautics and Space Administration — The Collection-3 Bromine Monoxide Product OMBRO from the Aura-OMI, is now available http://disc.gsfc.nasa.gov/Aura/OMI/ombro_v003.shtml) from the NASA Goddard Earth...

  1. Magnetoencephalographic correlates of different types of aura in temporal lobe epilepsy.

    Science.gov (United States)

    Fukao, Kenjiro; Inoue, Yushi; Yagi, Kazuichi

    2010-09-01

    To estimate magnetoencephalography (MEG) correlates of different types of aura in temporal lobe epilepsy (TLE). MEG study was performed on 57 patients (26 male and 31 female) with TLE, whose ages ranged from 14-46 years (mean 27 years). Interictal magnetoencephalograms showing discharges were analyzed, and spike-dipole clusters were categorized into left and right inferotemporal-horizontal (IH) and superotemporal-vertical (SV) types. Auras were classified into autonomic, auditory, and psychic seizures. The correlation between the four types of interictal spike-dipole and three types of aura was analyzed using Fisher's exact probability test. IH type correlated with autonomic seizures (p = 0.0004), whereas SV type correlated with both auditory (p = 0.0002) and psychic seizures (p = 0.042). When subdivided into left and right, left IH type correlated with autonomic seizures (p = 0.046), but right IH type did not. Right SV type correlated with both auditory (p = 0.014) and psychic seizures (p = 0.002), but left SV did not correlate with either. Both types did not correlate with "no aura." Using our proposed classification of spike-dipoles, MEG distinguishes auras of mesial temporal origin from those of lateral temporal region. Furthermore, by adopting our classification, laterality of spike-dipoles is clearly demonstrated in auditory and psychic seizures. Wiley Periodicals, Inc. © 2010 International League Against Epilepsy.

  2. Typical aura without headache: a case report and review of the literature.

    Science.gov (United States)

    He, Yusheng; Li, Yancheng; Nie, Zhiyu

    2015-02-24

    Typical aura without headache (TAWH), which has been rarely reported both at home and abroad, is a rare type of migraine with aura. This is a report on a 64-year-old Chinese migraineur who has had recurrent typical visual aura without headache attacks for more than 30 years, and has been misdiagnosed as having had transient ischemic attacks (TIA) many times. He mainly experienced episodes of 'homonymous blurred vision' or photopsia, which presented as different shapes located at the side or above his visual field, for example, patchy, cord-like, zigzag, curtain-like or irregular shapes. The shape was inconsistent during each attack, however, the color was mainly gray or light blue. The visual symptoms gradually disappeared in about 30 minutes. Our patient has never suffered a headache attack during or after the visual aura. Normal results were observed in his neurological and eye examinations, complete blood test, electroencephalogram and neuroimaging examination. TAWH is an uncommon phenomenon of migraine. Migraine with visual aura mainly presents positive and dynamic symptoms. It has a benign course and can be diagnosed after exclusion of other organic diseases such as TIA and epilepsy.

  3. Quantification of intrusive/retraction force and moment generated during en-masse retraction of maxillary anterior teeth using mini-implants: A conceptual approach

    Directory of Open Access Journals (Sweden)

    A. Sumathi Felicita

    Full Text Available ABSTRACT Objective: The aim of the present study was to clarify the biomechanics of en-masse retraction of the upper anterior teeth and attempt to quantify the different forces and moments generated using mini-implants and to calculate the amount of applied force optimal for en-masse intrusion and retraction using mini-implants. Methods: The optimum force required for en-masse intrusion and retraction can be calculated by using simple mathematical formulae. Depending on the position of the mini-implant and the relationship of the attachment to the center of resistance of the anterior segment, different clinical outcomes are encountered. Using certain mathematical formulae, accurate measurements of the magnitude of force and moment generated on the teeth can be calculated for each clinical outcome. Results: Optimum force for en-masse intrusion and retraction of maxillary anterior teeth is 212 grams per side. Force applied at an angle of 5o to 16o from the occlusal plane produce intrusive and retraction force components that are within the physiologic limit. Conclusion: Different clinical outcomes are encountered depending on the position of the mini-implant and the length of the attachment. It is possible to calculate the forces and moments generated for any given magnitude of applied force. The orthodontist can apply the basic biomechanical principles mentioned in this study to calculate the forces and moments for different hypothetical clinical scenarios.

  4. Effect of hypoxia on BOLD fMRI response and total cerebral blood flow in migraine with aura patients

    DEFF Research Database (Denmark)

    Arngrim, Nanna; Hougaard, Anders; Schytz, Henrik W

    2018-01-01

    Experimentally induced hypoxia triggers migraine and aura attacks in patients suffering from migraine with aura (MA). We investigated the blood oxygenation level-dependent (BOLD) signal response to visual stimulation during hypoxia in MA patients and healthy volunteers. In a randomized double...

  5. Abnormal brain processing of pain in migraine without aura: a high-density EEG brain mapping study

    DEFF Research Database (Denmark)

    Buchgreitz, L; Egsgaard, L L; Jensen, R

    2010-01-01

    In the present study we used high-density EEG brain mapping to investigate spatio-temporal aspects of brain activity in response to experimentally induced muscle pain in 17 patients with migraine without aura and 15 healthy controls. Painful electrical stimuli were applied to the trapezius muscle...... to the tonic muscle pain condition (z = 29 mm vs. z =¿-13 mm, P aura....

  6. Familial hemiplegic migraine locus on 19p13 is involved in the common forms of migraine with and without aura

    NARCIS (Netherlands)

    A. May (Arne); R.A. Ophoff (Roel); G.M. Terwindt (Gisela); C. Urban; R. van Eijk (Ronald); J. Haan (Joost); H.C. Diener (Hans Christoph); D. Lindhout (Dick); R.R. Frants (Rune); L.A. Sandkuijl (Lodewijk); M.D. Ferrari (Michel)

    1995-01-01

    textabstractMigraine is a common neurological disease of two main types: migraine with aura and migraine without aura. Familial clustering suggests that genetic factors are involved in the etiology of migraine. Recently, a gene for familial hemiplegic migraine, a rare autosomal dominant subtype of

  7. Primary intracranial angiomatoid fibrous histiocytoma presenting with anaemia and migraine-like headaches and aura as early clinical features

    DEFF Research Database (Denmark)

    Hansen, Jakob Møller; Larsen, Vibeke Andrée; Scheie, David

    2015-01-01

    A 17-year-old female with migraine with aura complained of fatigue and was diagnosed with anemia. Three years later, changes in her headache pattern prompted hospital referral. Brain MRI showed a bi-lobed extra-axial intracerebral tumor encroaching both parieto-occipital regions. The resection...... of an intracranial AFH presenting as migraine with visual aura and anemia....

  8. OMI/Aura Ozone (O3) Profile 1-Orbit L2 Swath 13x48km V003

    Data.gov (United States)

    National Aeronautics and Space Administration — The OMI/Aura Level-2 Ozone Profile data product OMO3PR (Version 003) is now available ( http://disc.gsfc.nasa.gov/Aura/OMI/omo3pr_v003.shtml ) from the NASA Goddard...

  9. OMI/Aura DOAS Total Column Ozone Zoomed 1-Orbit L2 Swath 13x12km V003

    Data.gov (United States)

    National Aeronautics and Space Administration — The reprocessed OMI/Aura Level-2 Zoomed Ozone data product OMDOAO3Z at 13x12 km resolution is now available (http://disc.gsfc.nasa.gov/Aura/OMI/omdoao3z_v003.shtml )...

  10. Attachment styles in children affected by migraine without aura

    Directory of Open Access Journals (Sweden)

    Esposito M

    2013-10-01

    Full Text Available Maria Esposito,1 Lucia Parisi,2 Beatrice Gallai,3 Rosa Marotta,4 Anna Di Dona,1 Serena Marianna Lavano,2 Michele Roccella,4 Marco Carotenuto11Center for Childhood Headache, Clinic of Child and Adolescent Neuropsychiatry, Department of Mental Health, Physical and Preventive Medicine, Second University of Naples, Naples, Italy; 2Child Neuropsychiatry, Department of Psychology, University of Palermo, Palermo, Italy; 3Unit of Child and Adolescent Neuropsychiatry, University of Perugia, Perugia, Italy; 4Department of Psychiatry, The Magna Graecia University of Catanzaro, Catanzaro, ItalyBackground: In recent years, great attention has been given to the presence of psychological problems and psychiatric comorbidity that are also present in children affected by primary headaches. The relationship between pain and attachment has been identified, and it may be that pain perception may change in relation with specific attachment styles. The aim of the present study was to assess the prevalent attachment style and verify its putative relationship and correlation with the main characteristics of migraine attacks, in school-aged children affected by migraine without aura (MoA.Materials and methods: The study population consisted of 219 children (103 males, 116 females aged between 6 and 11 years (mean 8.96 ± 2.14 years, consecutively referred for MoA compared with 381 healthy controls (174 males, 207 females; mean age 9.01 ± 1.75 years randomly selected from schools. All the children were classified according to the attachment typologies of the Italian modified version of the Separation Anxiety Test; monthly headache frequency and mean headache duration were assessed from daily headache diaries kept by all the children. Headache intensity was assessed on a visual analogue scale. The chi-square test and t-test, where appropriate, were applied, and the Spearman rank correlation test was applied to explore the relationship between the types of attachment

  11. Heart rate variability in sleep-related migraine without aura.

    Science.gov (United States)

    Vollono, Catello; Gnoni, Valentina; Testani, Elisa; Dittoni, Serena; Losurdo, Anna; Colicchio, Salvatore; Di Blasi, Chiara; Mazza, Salvatore; Farina, Benedetto; Della Marca, Giacomo

    2013-07-15

    This is an observational study aimed to investigate the activity of autonomic nervous system during sleep in patients with sleep-related migraine. Eight consecutive migraineurs without aura were enrolled (6 women and 2 men), aged 30 to 62 years (mean 48.1 ± 9.3 years). Inclusion criteria were: high frequency of attacks (> 5 per month) and occurrence of more than 75% of the attacks during sleep causing an awakening. Patients were compared with a control group of 55 healthy subjects (23 men and 32 women, mean age 54.2 ± 13.0 years), and with a further control group of 8 age- and gender-matched healthy controls. Patient and controls underwent polysomnography and heart rate variability analysis. A significant reduction of the LF/HF ratio during N2 and N3 sleep stages was observed in migraineurs compared with controls. No differences in sleep macrostructure were observed; cyclic alternating pattern (CAP) time and CAP rate were lower in migraineurs than in controls. These findings indicate a peculiar modification of the autonomic balance during sleep in sleep-related migraine. The reduction of LF/HF ratio in NREM sleep was observed in controls, but it was quantitatively much more evident in migraineurs. Changes in LF/HF could be consequent to an autonomic unbalance which could manifest selectively (or alternatively become more evident) during sleep. These findings, together with the reduction in CAP rate, could be an expression of reduced arousability during sleep in patients with sleep-related migraine. The simultaneous involvement of the autonomic, arousal, and pain systems might suggest involvement of the hypothalamic pathways.

  12. Migraine with aura and risk of silent brain infarcts and white matter hyperintensities

    DEFF Research Database (Denmark)

    Gaist, David; Garde, Ellen; Blaabjerg, Morten

    2016-01-01

    A small number of population-based studies reported an association between migraine with aura and risk of silent brain infarcts and white matter hyperintensities in females. We investigated these relations in a population-based sample of female twins. We contacted female twins ages 30-60 years...... identified through the population-based Danish Twin Registry. Based on questionnaire responses, twins were invited to participate in a telephone-based interview conducted by physicians. Headache diagnoses were established according to the International Headache Society criteria. Cases with migraine with aura......% confidence interval): 0.17 (-0.08 to 0.41) cm(3)] and a similar difference was present in analyses restricted to twin pairs discordant for migraine with aura [adjusted mean difference 0.21 (-0.20 to 0.63)], but these differences did not reach statistical significance. We found no evidence of an association...

  13. Migraine without aura is not associated with incomplete circle of Willis

    DEFF Research Database (Denmark)

    Ezzatian-Ahar, Shabnam; Amin, Faisal Mohammad; Obaid, Hayder Ghani

    2014-01-01

    the prevalence of incomplete circle of Willis in migraineurs and controls. In the present study we compared the prevalence of incomplete circle of Willis in female migraine patients without aura to female healthy non-migraine controls.Using 3-Tesla magnetic resonance angiography we recorded three......-dimensional time-of-flight angiograms in 85 female participants (48 migraine patients without aura [median age 28 years] and 37 healthy controls [median age 25 years]). The images were subsequently analysed blindly by a neuroradiologist to detect incomplete circle of Willis. FINDINGS: We found no difference...... between the prevalence of incomplete circle of Willis in patients, 20/47 (43%), and controls, 15/37 (41%), p = 0.252. Post hoc analysis showed a significant relationship between age and prevalence of incomplete circle of Willis, p = 0.003. CONCLUSION: We found no relationship between migraine without aura...

  14. Increased intrinsic brain connectivity between pons and somatosensory cortex during attacks of migraine with aura

    DEFF Research Database (Denmark)

    Hougaard, Anders; Amin, Faisal Mohammad; Larsson, Henrik B W

    2017-01-01

    The neurological disturbances of migraine aura are caused by transient cortical dysfunction due to waves of spreading depolarization that disrupt neuronal signaling. The effects of these cortical events on intrinsic brain connectivity during attacks of migraine aura have not previously been......-based approach focusing on cortical visual areas and areas involved in migraine pain, and a data-driven independent component analysis approach to detect changes in intrinsic brain signaling during attacks. In addition, we performed the analyses after mirroring the MRI data according to the side of perceived......-sided pain. For aura-side normalized data, we found increased connectivity during attacks between visual area V5 and the lower middle frontal gyrus in the symptomatic hemisphere (peak voxel: P = 0.0194, (x, y, z) = (40, 40, 12). The present study provides evidence of altered intrinsic brain connectivity...

  15. Bilateral inverse Duane′s retraction syndrome-A case report

    Directory of Open Access Journals (Sweden)

    Chatterjee Pranab

    1991-01-01

    Full Text Available Duane′s retraction syndrome is a well known congenital musculo-facial anomaly. Various explanations have been given for the aetiology of this syndrome. Inverse Duane′s retraction syndrome is a condition with reverse clinical features. Abduction of the affected eye is possible to some extent and is accompanied by retraction of the eyeball, narrowing of the palpebral fissure and pseudoptosis. There may be some restriction of movement on adduction. The primary lesion is suspected to be in the medial rectus muscle. Frequently the muscle is found to be entrapped following trauma to the medial wall of the orbit. A case of bilateral inverse Duane′s retraction syndrome and convergent squint along with left-sided perceptive deafness is reported. As is usually the case there was no structural abnormality or entrapment of the muscle from trauma.

  16. Retraction and expansion of flock mobility in central asia: costs and ...

    African Journals Online (AJOL)

    Retraction and expansion of flock mobility in central asia: costs and consequences. Carol Kerven, Ilya Ilych Alimaev, Roy Behnke, Grant Davidson, Leen Franchois, Nurlan Malmakov, Erik Mathijs, Aidos Smailov, Sayat Temirbekov, Iain Wright ...

  17. Effectiveness of mini implants in three-dimensional control during retraction - a clinical study

    National Research Council Canada - National Science Library

    Victor, Deepak; Prabhakar, Ramchandra; Karthikeyan, M K; Saravanan, R; Vanathi, P; Vikram, N Raj; Reddy, P Adarsh; Sudeepthi, M

    2014-01-01

    .... The purpose of this study was to compare and measure the vertical control and torque control of incisors and molar during enmass retraction with titanium microimplants and conventional molar anchorage...

  18. Rapid maxillary anterior teeth retraction en masse by bone compression: a canine model

    National Research Council Canada - National Science Library

    Liu, Chufeng; Cao, Yang; Liu, Conghua; Zhang, Jincai; Xu, Pingping

    2011-01-01

    The present study sought to establish an animal model to study the feasibility and safety of rapid retraction of maxillary anterior teeth en masse aided by alveolar surgery in order to reduce orthodontic treatment time...

  19. Retraction Note: Radiation Sialadenitis Induced by High-dose Radioactive Iodine Therapy

    Energy Technology Data Exchange (ETDEWEB)

    Jeong, Shin Young; Lee, Jaetae [Kyungpook National Univ. Hospital, Daegu (Korea, Republic of)

    2014-06-15

    The senior author (J. Lee) and the first author (S. Y. Jeong) have retracted this review article due to misconduct. They have discovered multiple instances of misreferencing and misquotation in the text which raise the concern of potential plagiarism.

  20. [Two cases of koro syndrome or anxiety disorder associated with genital retraction fear].

    Science.gov (United States)

    Atalay, Hakan

    2007-01-01

    As a cultural-bound syndrome, koro is described in the DSM-IV as "an episode of sudden and intense anxiety that the penis (or, in females, the vulva and the nipples) will recede into the body and possibly cause death." Sometimes the syndrome may occur as an epidemic involving several hundreds to thousands of subjects within a short period of time. While the syndrome individually involves an anxiety reaction and fear of mortal genital retraction, it collectively takes the form of epidemics and mass panic. Recently a consensus has been reached about the fact that genital retraction is intimately related not only with ethno-cultural beliefs but also with the dramatic expression of acute anxiety and fear of impending catastrophe or death. We present two cases of koro syndrome who experienced severe anxiety due to the feeling of genital retraction and thus we question the cultural specifity of fears of genital retraction.

  1. Increased cerebrovascular pCO2 reactivity in migraine with aura--a transcranial Doppler study during hyperventilation

    DEFF Research Database (Denmark)

    Thomsen, L L; Iversen, Helle Klingenberg; Olesen, J

    1995-01-01

    Cerebrovascular reactivity during hypocapnia was tested in 20 migraineurs (8 with aura, 12 without aura) and 30 sex- and age-matched healthy subjects, and during nitroglycerin-induced headache in 12 healthy subjects. Before and during hyperventilation, mean blood-flow velocity (Vmean) in the middle...... cerebral artery was measured with transcranial Doppler. In each subject a pCO2 reactivity index (RI) was calculated as (delta Vmean/baseline Vmean)/delta pCO2. Interictally, patients with migraine with aura showed higher RI (p ... aura did not differ from healthy subjects. Ictal and interictal RIs were similar in 9 patients suffering from migraine without aura. No side-to-side differences were detected in RI. During nitroglycerin-induced headache, the RIs were no different from those recorded during migraine attacks and in non...

  2. Ischemic stroke subtypes and migraine with visual aura in the ARIC study.

    Science.gov (United States)

    Androulakis, X Michelle; Kodumuri, Nishanth; Giamberardino, Lauren D; Rosamond, Wayne D; Gottesman, Rebecca F; Yim, Eunsil; Sen, Souvik

    2016-12-13

    To investigate the association among migraine, ischemic stroke, and stroke subtypes in the Atherosclerosis Risk in Communities (ARIC) study. In this ongoing, prospective, longitudinal community-based cohort study, participants were given an interview ascertaining migraine history in 1993-1995, and were followed for all vascular events, including stroke. All stroke events over the subsequent 20 years were adjudicated and classified into stroke subtypes by standard definitions. Cox proportional hazards models adjusted for stroke risk factors were used to study the relationship between migraine and ischemic stroke, overall, as well as stroke subtypes (cardioembolic, lacunar, or thrombotic). We identified 1,622 migraineurs among 12,758 participants. Mean age of the study population at the 3rd clinical visit was 59 years. When compared to nonheadache participants, there was a significant association between migraine with visual aura and ischemic stroke (hazard ratio [HR] 1.7, 95% confidence interval [CI] 1.2-2.6, p = 0.008). Migraine without visual aura was not significantly associated with ischemic stroke (HR 1.2, CI 1.0-1.8, p = 0.28) when compared to nonheadache participants. Among the 3 subtypes of ischemic stroke evaluated, migraine with visual aura was significantly associated only with cardioembolic stroke (HR 3.7, 95% CI 1.6-8.7, p = 0.003). In participants with migraine with visual aura in late middle age, increased risk of cardioembolic stroke was observed. Migraine with visual aura was linked to increased stroke risk, while migraine without visual aura was not, over the period of 20 years. These results are specific to older migraineurs. © 2016 American Academy of Neurology.

  3. RETRACTED: Facies analysis and depositional environments of the Oligocene–Miocene Asmari Formation, Zagros Basin, Iran

    OpenAIRE

    Sahraeyan, Mohammad; Bahrami, Mohammad; Arzaghi, Solmaz

    2014-01-01

    This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). This article has been retracted at the request of the Editor-in-Chief. The article duplicates significant parts of three other articles without proper citations (Allahkarampour Dill, M., Seyrafian, A., Vaziri-Moghaddam, H., 2010. The Asmari Formation, north of the Gascharan (Dill anticline), southwest Iran: facies analysis, depositional environments and se...

  4. Intramuscular fat accumulation and muscle atrophy in the absence of muscle retraction

    OpenAIRE

    Uhthoff, H K; Coletta, E.; Trudel, G.

    2014-01-01

    Objectives Although many clinical and experimental investigations have shed light on muscle atrophy and intramuscular accumulation of fat after rotator cuff disruption, none have reported on their onset in the absence of muscle retraction. Methods In 30 rabbits, we detached one supraspinatus (SSP) tendon and repaired it immediately, thus preventing muscle retraction. The animals were killed in groups of 10 at one, two and six weeks. Both shoulders of 15 non-operated rabbits served as controls...

  5. Retraction: Two novel duck antibacterial peptides, avian β-defensins 9 and 10, with antimicrobial activity.

    Science.gov (United States)

    2013-01-01

    The article by Ma et al. that published in the Journal of Microbiology and Biotechnology (2009, 19: 1447-1455) was used the same data in two journal articles (Acta Veterinaria et Zootechnica Sinica, 2009, 40(9): 1320-1326, Scientia Agricultura Sinica, 2009, 42(4): 1406-1412). Therefore, the article is retracted from JMB as a misconduct of the authors. JMB as the publisher regrets for any inconvenience may have caused by the retraction to readers.

  6. RETRACTED: A novel technique of multi-track percutaneous balloon mitral commissurotomy (PBMC

    Directory of Open Access Journals (Sweden)

    Sherif A. Sakr

    2012-07-01

    This paper has been retracted upon mutual agreement between the publisher and the Editor-in-Chief of EJCDT when it was discovered that this article had also been submitted and published in the International Heart Journal http://dx.doi.org/10.1536/ihj.54.196. The authors did not give clarification for the action, therefore the paper was retracted following international publishing practices.

  7. [Retraction of: Diagnostics and treatment of early stages of oral cancer].

    Science.gov (United States)

    Warloe, Trond; Aamdal, Steinar; Reith, Albrecht; Bryne, Magne

    2006-09-07

    The undersigned, who are co-authors of the article Diagnostics and treatment of early stages of oral cancer, wish to retract it. The reason is that the basis for the review article has been shown to be false. A review committee, that has assessed the research activity of the main author, has concluded that the data in this article are fabricated. We can no longer stand behind the article and hereby retract it.

  8. Calcitonin gene-related peptide triggers migraine-like attacks in patients with migraine with aura

    DEFF Research Database (Denmark)

    Hansen, Jakob Møller; Hauge, Anne Werner; Olesen, J.

    2010-01-01

    Calcitonin gene-related peptide (CGRP) is a key molecule in migraine pathogenesis. Intravenous CGRP infusion triggers delayed migraine-like attacks in patients with migraine without aura (MO). In contrast to patients with MO, in prior studies patients with familial hemiplegic migraine (FHM) did...... not report more migraine-like attacks compared to controls. Whether CGRP triggers migraine in patients with typical (non-hemiplegic) migraine with aura is (MA) unknown. In the present study we examined the migraine inducing effect of CGRP infusion in patients suffering from MA and healthy controls....

  9. Peri-ictal changes of cortical excitability in children suffering from migraine without aura

    DEFF Research Database (Denmark)

    Siniatchkin, Michael; Reich, Anna-Lena; Shepherd, Alex J

    2009-01-01

    regional excitability of the occipital (phosphene threshold [PT] and suppression of visual perception) and motor (resting motor threshold and cortical silent period) cortex in ten children suffering from migraine without aura and ten healthy age-matched controls. Patients were studied 1-2 days before...... aftereffect. Motor cortex excitability was not altered in patients and did not change during the migraine cycle. These findings show that pediatric migraine without aura is associated with a systematic shift in occipital excitability preceding the migraine attack. Similar systematic fluctuations in cortical...

  10. Carbachol induces headache, but not migraine-like attacks, in patients with migraine without aura

    DEFF Research Database (Denmark)

    Schytz, H W; Wienecke, T; Olesen, J

    2009-01-01

    Schytz HW, Wienecke T, Olesen J & Ashina M. Carbachol induces headache, but not migraine-like attacks, in patients with migraine without aura. Cephalalgia 2009. London. ISSN 0333-1024Carbachol induces headache in healthy subjects, but the migraine eliciting effect of carbachol has not previously...... been studied. We hypothesized that the cholinomimetic agonist carbachol would induce headache and migraine-like attacks in migraineurs. Carbachol (3 microg/kg) or placebo was randomly infused into 18 patients with migraine without aura in a double-blind crossover study. Headache was scored on a verbal...

  11. Migraine with aura is associated with an incomplete circle of willis: results of a prospective observational study.

    Directory of Open Access Journals (Sweden)

    Brett Cucchiara

    Full Text Available To compare the prevalence of an incomplete circle of Willis in patients with migraine with aura, migraine without aura, and control subjects, and correlate circle of Willis variations with alterations in cerebral perfusion.Migraine with aura, migraine without aura, and control subjects were prospectively enrolled in a 1∶1∶1 ratio. Magnetic resonance angiography was performed to examine circle of Willis anatomy and arterial spin labeled perfusion magnetic resonance imaging to measure cerebral blood flow. A standardized template rating system was used to categorize circle of Willis variants. The primary pre-specified outcome measure was the frequency of an incomplete circle of Willis. The association between circle of Willis variations and cerebral blood flow was also analyzed.170 subjects were enrolled (56 migraine with aura, 61 migraine without aura, 53 controls. An incomplete circle of Willis was significantly more common in the migraine with aura compared to control group (73% vs. 51%, p = 0.02, with a similar trend for the migraine without aura group (67% vs. 51%, p = 0.08. Using a quantitative score of the burden of circle of Willis variants, migraine with aura subjects had a higher burden of variants than controls (p = 0.02. Compared to those with a complete circle, subjects with an incomplete circle had greater asymmetry in hemispheric cerebral blood flow (p = 0.05. Specific posterior cerebral artery variants were associated with greater asymmetries of blood flow in the posterior cerebral artery territory.An incomplete circle of Willis is more common in migraine with aura subjects than controls, and is associated with alterations in cerebral blood flow.

  12. Pattern Visual Evoked Potential, Pattern Electroretinogram, and Retinal Nerve Fiber Layer Thickness in Patients with Migraine during and after Aura.

    Science.gov (United States)

    El-Shazly, Amany Abd El-Fattah; Farweez, Yousra Ahmed; Hamdi, Momen Mahmoud; El-Sherbiny, Noha Ezzat

    2017-09-01

    To study pattern visual evoked potential (PVEP), pattern electroretinogram (PERG), and retinal nerve fiber layer (RNFL) thickness in patients with migraine during and after aura. We included 60 eyes of 60 patients with migraine (Group 1) and 30 healthy volunteers (30 eyes) as controls (Group 2). Group 1 was studied twice, during a visual aura (1-a) and in between attacks (1-b). All participants underwent full ophthalmological examination, PVEP, PERG, and optical coherence tomographyOCT imaging of the RNFL thickness for each patient. RNFL thickness was found to be thinner in patients during the aura compared to controls. It increased significantly post-aura but remained lower than the controls. Prolonged P100 latency and decreased amplitude were found in patients during aura compared to controls with significant change in between attacks to values comparable to the controls. We found prolonged N95 latency and decreased amplitude in patients during aura compared to controls with significant change post-aura to values comparable to the controls. There was positive correlation between average RNFL thicknesses and VA and spherical equivalent; but it showed negative correlation with duration of migraine, attack duration, and aura duration. Multiple regression analysis showed that the most important determinants of average RNFL thickness in patients of migraine were attack and aura duration (beta = -0.21 and -0.26 and p = 0.03 and 0.04, respectively). Migraine attacks impose both functional and structural retinal changes. The functional changes are fully reversible after the aura but not the structural ones. So, vigorous prevention of migraine attacks would be protective for retina.

  13. Migraine with aura is associated with an incomplete circle of willis: results of a prospective observational study.

    Science.gov (United States)

    Cucchiara, Brett; Wolf, Ronald L; Nagae, Lidia; Zhang, Quan; Kasner, Scott; Datta, Ritobrato; Aguirre, Geoffrey K; Detre, John A

    2013-01-01

    To compare the prevalence of an incomplete circle of Willis in patients with migraine with aura, migraine without aura, and control subjects, and correlate circle of Willis variations with alterations in cerebral perfusion. Migraine with aura, migraine without aura, and control subjects were prospectively enrolled in a 1∶1∶1 ratio. Magnetic resonance angiography was performed to examine circle of Willis anatomy and arterial spin labeled perfusion magnetic resonance imaging to measure cerebral blood flow. A standardized template rating system was used to categorize circle of Willis variants. The primary pre-specified outcome measure was the frequency of an incomplete circle of Willis. The association between circle of Willis variations and cerebral blood flow was also analyzed. 170 subjects were enrolled (56 migraine with aura, 61 migraine without aura, 53 controls). An incomplete circle of Willis was significantly more common in the migraine with aura compared to control group (73% vs. 51%, p = 0.02), with a similar trend for the migraine without aura group (67% vs. 51%, p = 0.08). Using a quantitative score of the burden of circle of Willis variants, migraine with aura subjects had a higher burden of variants than controls (p = 0.02). Compared to those with a complete circle, subjects with an incomplete circle had greater asymmetry in hemispheric cerebral blood flow (p = 0.05). Specific posterior cerebral artery variants were associated with greater asymmetries of blood flow in the posterior cerebral artery territory. An incomplete circle of Willis is more common in migraine with aura subjects than controls, and is associated with alterations in cerebral blood flow.

  14. Can triggered electromyography monitoring throughout retraction predict postoperative symptomatic neuropraxia after XLIF? Results from a prospective multicenter trial.

    Science.gov (United States)

    Uribe, Juan S; Isaacs, Robert E; Youssef, Jim A; Khajavi, Kaveh; Balzer, Jeffrey R; Kanter, Adam S; Küelling, Fabrice A; Peterson, Mark D

    2015-04-01

    This multicenter study aims to evaluate the utility of triggered electromyography (t-EMG) recorded throughout psoas retraction during lateral transpsoas interbody fusion to predict postoperative changes in motor function. Three hundred and twenty-three patients undergoing L4-5 minimally invasive lateral interbody fusion from 21 sites were enrolled. Intraoperative data collection included initial t-EMG thresholds in response to posterior retractor blade stimulation and subsequent t-EMG threshold values collected every 5 min throughout retraction. Additional data collection included dimensions/duration of retraction as well as pre-and postoperative lower extremity neurologic exams. Prior to expanding the retractor, the lowestt-EMG threshold was identified posterior to the retractor in 94 % of cases. Postoperatively, 13 (4.5 %) patients had a new motor weakness that was consistent with symptomatic neuropraxia (SN) of lumbar plexus nerves on the approach side. There were no significant differences between patients with or without a corresponding postoperative SN with respect to initial posterior blade reading (p = 0.600), or retraction dimensions (p > 0.05). Retraction time was significantly longer in those patients with SN vs. those without (p = 0.031). Stepwise logistic regression showed a significant positive relationship between the presence of new postoperative SN and total retraction time (p neuropraxia may be reduced by limiting retraction time and utilizing t-EMG throughout retraction, while understanding that the specificity of this monitoring technique is low during initial retraction and increases with longer retraction duration.

  15. Retraction With Face Saving: modelling conversational interaction through dynamic hypermedia

    Directory of Open Access Journals (Sweden)

    Roberto Bolognesi

    1994-12-01

    Full Text Available This paper describes RWFS (Retraction With Face Saving, a hypermedia application which models an interview between a lawyer and his client - a lorry driver - facing court charges of reckless driving. At one level RWFS takes the form of a sophisticated game in which different outcomes to the interview are possible according to the learner's degree of skill. At another level, RWFS is designed to encourage the language learner's awareness and understanding of the pragmatic features of conversation. RWFS runs on HyperContext, a hybrid hypertextlexpert system developed in Pavia by two of the authors, Marco Piastra and Roberto Bolognesi, and which supports dynamic hypermedia units. HyperContext's dynamic linking capacity plays a vital role in simulating significant conversational features such as the conditioning of a current move in the conversation by information acquired much earlier in the course of the interview. In this connection, the paper discusses the contribution of RMCI (Re-usable Model of Conversational Interaction, a re-usable application-independent applied model of interaction on which the game is based, and which links a tactical level (the conversation to a metalevel which provides a moveby- move commentary on interactional theory. In its turn, RMCFs metalevel is linked to a strategic level which interprets the structure of the conversation in terms of a pyramid-like hierarchy of increasingly abstract theoretical concepts.

  16. Management of Duane retraction syndrome with prismatic glasses

    Science.gov (United States)

    Aygit, Ebru Demet; Kocamaz, Murat; Inal, Asli; Fazil, Korhan; Ocak, Osman Bulut; Akar, Serpil; Gokyigit, Birsen

    2017-01-01

    Purpose To report the results of using prismatic glasses for Duane retraction syndrome (DRS). Methods Data were obtained from the records of patients who were evaluated during the year 2000 in the Strabismus Unit of the Beyoglu Eye Training and Research Hospital. The average follow-up was 12.2±17.7 months. In all cases, 2 main variables were evaluated: horizontal deviation in the primary position and face turn. Prismatic glasses were provided to patients according to the degree of shift in the primary position. Results The mean age of patients was 11.2 years. An analysis was performed on the data collected from 12 cases; 7 patients were females (58.3%) and 5 were males (41.7%), with 11 (91.7%) cases being of type I DRS. All 12 patients had abnormal head posture (face turn) and an angle of mean deviation equaling 10 PD (prism dioptri). Conclusion Treatment was individualized on a case-by-case basis. Prismatic glasses are useful for eliminating abnormal head posture and ocular misalignment in selected cases. PMID:28442887

  17. Learned navigation in unknown terrains: A retraction method

    Science.gov (United States)

    Rao, Nageswara S. V.; Stoltzfus, N.; Iyengar, S. Sitharama

    1989-01-01

    The problem of learned navigation of a circular robot R, of radius delta (is greater than or equal to 0), through a terrain whose model is not a-priori known is considered. Two-dimensional finite-sized terrains populated by an unknown (but, finite) number of simple polygonal obstacles are also considered. The number and locations of the vertices of each obstacle are unknown to R. R is equipped with a sensor system that detects all vertices and edges that are visible from its present location. In this context two problems are covered. In the visit problem, the robot is required to visit a sequence of destination points, and in the terrain model acquisition problem, the robot is required to acquire the complete model of the terrain. An algorithmic framework is presented for solving these two problems using a retraction of the freespace onto the Voronoi diagram of the terrain. Algorithms are then presented to solve the visit problem and the terrain model acquisition problem.

  18. Effects of Duane's retraction syndrome on sensory visual development.

    Science.gov (United States)

    Sloper, J S; Collins, A D

    1999-03-01

    To study the effects of Duane's retraction syndrome on sensory visual development. Monocular and binocular visual function and ocular motility have been studied and pattern reversal visual evoked potentials recorded from 22 patients with Duane's syndrome aged from 4 to 55 years. Sixteen of the patients maintained binocular single vision using an abnormal head posture. All had normal visual acuities in both eyes. The 12 adults in this group had a mean stereoacuity of 78 seconds of arc with the Titmus stereotest and 101 seconds of arc with the TNO test. Both these values were significantly worse than for normal adults with a similar age range. The binocular VEPs from these patients showed enhancement of the binocular P100 VEP amplitude compared to the mean monocular P100 amplitude when they used their head posture but, unlike in normal subjects, this binocular enhancement was not reduced significantly after the age of 5. Six patients had lost binocular function and had a manifest convergent squint. Of these, 4 were anisometropic. VEPs in this group showed mildly delayed P100 latencies in the affected eye with asymmetric amplitudes even though their amblyopia had been successfully treated by patching and only one patient had a substantially reduced acuity. In neither group was there any relationship between the degree of restriction of ocular motility and the sensory changes. Patients with Duane's syndrome who retain binocular single vision show abnormal binocular visual maturation after the age of 5 years. This results in reduced stereoacuity in the absence of amblyopia.

  19. Investigations of functional and structural changes in migraine with aura by magnetic resonance imaging.

    Science.gov (United States)

    Hougaard, Anders

    2015-08-01

    Migraine sufferers with aura often report visual discomfort outside of attacks and many consider bright or flickering light an attack-precipitating factor. The nature of this visual hypersensitivity and its relation to the underlying pathophysiology of the migraine aura is unknown. A useful technology to study these features of migraine with aura (MA) is functional magnetic resonance imaging (fMRI), which has the potential not only to detect, but also to localize hypersensitive cortex. The main objective of this thesis was to investigate the cortical responsivity of patients with MA during visual stimulation using fMRI. To optimize sensitivity, we applied a within-patient design by assessing functional interhemispheric differences in patients consistently experiencing visual aura in the same visual hemifield. To validate our data analysis methods, we initially studied healthy volunteers using single hemifield visual stimulation and compared the "stimulated" hemispheres (i.e. hemispheres contralateral to the visual stimulation) to the "non-stimulated" hemispheres. We then applied this validated method of interhemispheric comparison of fMRI-blood oxygenation level dependent (BOLD) activation to compare left versus right hemisphere responses to symmetric full-field visual stimulation in 54 healthy subjects (study I). This study concluded that, a) the applied visual stimulation is effective in activating large expanses of visual cortex, b) interhemispheric differences in fMRI-BOLD activation can be determined using the proposed method, and c) visual responses to symmetric full-field visual stimulation are asymmetrically distributed between the cerebral hemispheres. We investigated the effects of migraine aura, by including 20 patients with frequent side-fixed visual aura attacks, i.e. ≥= 90% of auras occurring in the same visual hemifield (study II). To circumvent bias relating to differences between right and left hemispheres (e.g. caused by physiological left

  20. Estudio oftalmológico de la migraña con aura visual Ophthalmological study of migraine with visual aura

    Directory of Open Access Journals (Sweden)

    María Cáceres Toledo

    2005-06-01

    Full Text Available En la migraña con aura visual, la cefalea va precedida por la aparición de escotomas centelleantes y pérdida de la visión en la mitad del campo visual entre otros síntomas. Se estudió un grupo de pacientes migrañosos con aura visual con el objetivo de determinar las alteraciones oftalmológicas y los defectos de refracción que aparecen en estos casos y cuales de éstas pueden agravar sus crisis. Se realizó un estudio oftalmológico completo, a 30 pacientes con este diagnóstico, que incluyó la refracción, la medida del punto próximo de convergencia, y la amplitud de fusión. Se considera que la disminución de la amplitu de fusión pudiera ser un factor desencadenante en la aparición de las crisis de migrañaIn the migraine with visual aura, headache is preceded by the appearance of sparkling scotomas and the loss of vision in half of the visual field, among other symptoms. A group of patients suffering from migraine with visual aura was studied aimed at determining the ophthalmological alterations and the refraction defects appearing in these cases and which of them may worsen their crises. A complete ophthalmological study was conducted in 30 patients with this diagnosis that included refraction, the measurement of the proximal point of convergence and the amplitude of fusion. It is considered that the reduction of the amplitude of fusion may be a precipitating factor in the emergence of migraine crises

  1. Eficácia de três drogas sobre a aura migranosa: um estudo randomizado placebo controlado Efficacy of three drugs in the treatment of migrainous aura: a randomized, placebo-controlled study

    Directory of Open Access Journals (Sweden)

    Marcelo E. Bigal

    2002-06-01

    Full Text Available A despeito da enorme quantidade de pesquisas referentes à classificação, epidemiologia, diagnóstico, fisiopatologia e tratamento da migrânea, a aura migranosa permanece bem menos estudada. O objetivo do presente estudo é, portanto, verificar a evolução da aura em pacientes submetidos a placebo e a três diferentes drogas disponíveis em unidades públicas de saúde brasileiras. Foram estudados 86 pacientes em vigência de crise de migrânea com aura, apresentando aura no momento da randomização. Após a randomização os pacientes recebiam uma das seguintes substâncias, por via endovenosa: placebo, dipirona, clorpromazina, sulfato de magnésio. O sulfato de magnésio foi superior ao placebo (p In spite of the enormous amount of research regarding classification, epidemiology, diagnosis, pathophisiology and treatment of migraines, aura, one of its hallmarks, stays much less studied. The objective of this study is, therefore, to evaluate the evolution of aura in patients submitted to placebo and three different drugs available in Brazilian public health units. We studied 86 patients during an acute migrainous attack, with aura at the moment of the evaluation. Patients were randomized to receive one of the following substances, in a parenteral route: placebo, dipyrone, chlorpromazine and magnesium sulphate. Magnesium sulphate was superior to placebo (p <0,05 30 and 60 minutes after its administration. Dipyrone and chlorpromazine reduced the duration of the aura, when compared to placebo, 60 minutes following their administration. Our findings make possible some speculations about the pathophisiology of migraine, as well as about the therapeutic approach of patients presenting migrainous aura.

  2. Is SOD2 Ala16Val polymorphism associated with migraine with aura phenotype?

    Science.gov (United States)

    Palmirotta, Raffaele; Barbanti, Piero; De Marchis, Maria Laura; Egeo, Gabriella; Aurilia, Cinzia; Fofi, Luisa; Ialongo, Cristiano; Valente, Maria Giovanna; Ferroni, Patrizia; Della-Morte, David; Guadagni, Fiorella

    2015-01-20

    Several studies suggest a role of oxidative stress in the physiopathology of migraine, particularly in the form with aura. In a case-control study, we investigated the association between migraine and superoxide dismutase 1 (SOD1) and superoxide dismutase 2 (SOD2) genes in a cohort of 490 consecutive unrelated Caucasian migraineurs (migraine with aura [MwA], n=107; migraine without aura [MwoA], n=246; chronic migraine [CM], n=137) and 246 healthy controls recruited at our Headache and Pain Unit and stored in the Interinstitutional Multidisciplinary BioBank (BioBIM). Migraine phenotype was carefully detailed using face-to-face interviews. We examined polymorphisms of SOD1 gene (A/C substitution-rs2234694) and SOD2 gene (C/T transition-rs4880-Ala16Val). The rs4880 TT (Val/Val) genotype was associated (p=0.042) with the presence of unilateral cranial autonomic symptoms (UAs) in MwA patients. We also found a mild correlation between SOD2 rs4880 genotype and the type of acute migraine treatment (p=0.048) in MwA patients. Our findings suggest that SOD2 is a disease-modifier gene influencing oxidative mechanisms in MwA. These observations lead to the hypothesis that SOD2 polymorphism may cause a defective control of the oxidative phenomena linked to cortical spreading depression, the neurophysiological hallmark of migraine aura, causing an overstimulation of trigeminal neurons and UAs triggering.

  3. Intact neurovascular coupling during executive function in migraine without aura: interictal near-infrared spectroscopy study

    DEFF Research Database (Denmark)

    Schytz, H W; Ciftçi, K; Akin, A

    2010-01-01

    An altered neurovascular coupling has been proposed in migraine. We aimed to investigate neurovascular coupling during a mental task interictally in patients with migraine without aura (MO) by near-infrared spectroscopy (NIRS). Twelve migraineurs and 12 healthy controls were included. Using NIRS...

  4. Highlights from a Decade of OMI-TOMS Total Ozone Observations on EOS Aura

    Science.gov (United States)

    Haffner, David P.; Bhartia, Pawan K.; McPeters, Richard D.; Joiner, Joanna; Ziemke, Jerald R.; Vassilkov, Alexander; Labow, Gordon J.; Chiou, Er-Woon

    2014-01-01

    Total ozone measurements from OMI have been instrumental in meeting Aura science objectives. In the last decade, OMI has extended the length of the TOMS total ozone record to over 35 years to monitor stratospheric ozone recovery. OMI-TOMS total ozone measurements have also been combined synergistically with measurements from other Aura instruments and MLS in particular, which provides vertically resolved information that complements the total O3 mapping capability of OMI. With this combined approach, the EOS Aura platform has produced more accurate and detailed measurements of tropospheric ozone. This has led in turn to greater understanding of the sources and transport of tropospheric ozone as well as its radiative forcing effect. The combined use of OMI and MLS data was also vital to the analysis of the severe Arctic ozone depletion event of 2011. The quality of OMI-TOMS total O3 data used in these studies is the result of several factors: a mature and well-validated algorithm, the striking stability of the OMI instrument, and OMI's hyperspectral capabilities used to derive cloud pressures. The latter has changed how we think about the effects of clouds on total ozone retrievals. We will discuss the evolution of the operational V8.5 algorithm and provide an overview and motivation for V9. After reviewing results and developments of the past decade, we finally highlight how ozone observations from EOS Aura are playing an important role in new ozone mapping missions.

  5. Vitamin supplementation as possible prophylactic treatment against migraine with aura and menstrual migraine.

    Science.gov (United States)

    Shaik, Munvar Miya; Gan, Siew Hua

    2015-01-01

    Migraine is the most common form of headache disorder globally. The etiology of migraine is multifactorial, with genetic components and environmental interactions considered to be the main causal factors. Some researchers postulate that deficits in mitochondrial energy reserves can cause migraine or an increase in homocysteine levels can lead to migraine attacks; therefore, vitamins could play a vital role in migraine prevention. For instance, riboflavin influences mitochondrial dysfunction and prevents migraine. Genes such as flavoenzyme 5,10-methylenetetrahydrofolate reductase (MTHFR), especially the C677T variant, have been associated with elevated plasma levels of homocysteine and migraine with aura. Homocysteine catalyzation requires the presence of vitamins B6, B12, and folic acid, which can decrease the severity of migraine with aura, making these vitamins potentially useful prophylactic agents for treating migraine with aura. Menstrual migraine, on the other hand, is associated with increased prostaglandin (PG) levels in the endometrium, indicating a role for vitamin E, which is an anti-PG. Vitamin C can also be used as a scavenger of reactive oxygen species for treating neurogenic inflammation in migraine patients. This paper reviews possible therapies based on vitamin supplementation for migraine prophylaxis, focusing on migraine with aura and menstrual migraine.

  6. Aqua-Aura QuickDAM (QDAM) 2.0 Ops Concept

    Science.gov (United States)

    Nidhiry, John

    2015-01-01

    The presentation describes the Quick Debris Avoidance Maneuver (QDAM) 2.0 process used the Aqua and Aura flight teams to (a) reduce the work load and dependency on staff and systems; (b) reduce turn-around time and provide emergency last minute capabilities; and (c) increase burn parameter flexibility. The presentation also compares the QDAM 2.0 process to previous approaches.

  7. Reduced functional connectivity between salience and visual networks in migraine with aura.

    Science.gov (United States)

    Niddam, David M; Lai, Kuan-Lin; Fuh, Jong-Ling; Chuang, Chih-Ying Naomi; Chen, Wei-Ta; Wang, Shuu-Jiun

    2016-01-01

    Migraine with visual aura (MA) is associated with distinct visual disturbances preceding migraine attacks, but shares other visual deficits in between attacks with migraine without aura (MO). Here, we seek to determine if abnormalities specific to interictal MA patients exist in functional brain connectivity of intrinsic cognitive networks. In particular, these networks are involved in top-down modulation of visual processing. Using resting-state functional magnetic resonance imaging, whole-brain functional connectivity maps were derived from seeds placed in the anterior insula and the middle frontal gyrus, key nodes of the salience and dorsal attention networks, respectively. Twenty-six interictal MA patients were compared with 26 matched MO patients and 26 healthy matched controls. The major findings were: connectivity between the anterior insula and occipital areas, including area V3A, was reduced in MA but not in MO. Connectivity changes between the anterior insula and occipital areas further correlated with the headache severity in MA only. The unique pattern of connectivity changes found in interictal MA patients involved area V3A, an area previously implicated in aura generation. Hypoconnectivity to this and other occipital regions may either represent a compensatory response to occipital dysfunctions or predispose MA patients to the development of aura. © International Headache Society 2015.

  8. MLS/Aura Near-Real-Time L2 Ozone (O3) Mixing Ratio V003

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2O3_NRT is the EOS Aura Microwave Limb Sounder (MLS) Near-Real-Time (NRT) product for ozone (O3). This product contains daily O3 profiles taken from the 240 GHz...

  9. Prostaglandin (E2) induces immediate migraine-like attack in migraine patients without aura

    DEFF Research Database (Denmark)

    Antonova, Maria; Wienecke, Troels; Olesen, Jes

    2012-01-01

    without aura were randomly allocated to receive 0.4 µg/kg/min PGE(2) (Prostin®E2, dinoprostone) or placebo over 25 minutes in a two-way, crossover study. Headache intensity was recorded on a verbal rating scale, middle cerebral artery blood flow velocity (V(MCA)) was measured by transcranial Doppler (TCD...

  10. Headache symptoms from migraine patients with and without aura through structure-validated self-reports.

    Science.gov (United States)

    Wang, Jiawei; Zhang, Bingren; Shen, Chanchan; Zhang, Jinhua; Wang, Wei

    2017-10-12

    Headache symptoms self-reported by migraine patients are largely congruent with the clinician-used diagnostic criteria, but not always so. Patients' self-reports of headache symptoms might offer additional clues to characterize migraine with (MA) and without (MO) aura more precisely. Firstly, we invited 324 participants with a life-long headache attack to answer an item-matrix measuring symptoms of primary headaches, then we performed both exploratory and confirmatory factor analyses to their answers and refined a headache symptom questionnaire. Secondly, we applied this questionnaire to 28 MA and 52 MO patients. In participants with a life-long headache, we refined a 27-item, structure-validated headache symptom questionnaire, with four factors (scales) namely the Somatic /Aura Symptoms, Gastrointestinal and Autonomic Symptoms, Tightness and Location Features, and Prodromal/Aggravating Symptoms. Further, we found that MA patients reported higher than did MO patients on the Somatic/Aura Symptoms and Tightness and Location Features scales. Compared to MO, MA was conferred with more prominent tightness and location features besides its higher somatic or aura symptoms. Patients' self-reports of headache symptoms might offer more clues to distinguish two types of migraine besides their clinician-defined criteria.

  11. Transient Splenial Lesion of the Corpus Callosum Related to Migraine with Aura in a Pediatric Patient.

    Science.gov (United States)

    Ünver, Olcay; Kutlubay, Büşra; Besci, Tolga; Ekinci, Gazanfer; Baltacıoğlu, Feyyaz; Türkdoğan, Dilşad

    Transient splenial lesions of the corpus callosum are rare radiological findings first described in association with epilepsy, antiepileptic drugs and viral encephalitis. However, subsequently more cases were described associated with diverse clinical conditions. We describe a 13-year-old girl suffering from migraine with aura presenting with headache, right-sided hemiparesis and encephalopathy. Brain magnetic resonance imaging revealed an ovoid lesion in the splenium of the corpus callosum. The patient's neurological symptoms resolved within 3 days without therapy and the lesion disappeared in follow up magnetic resonance images obtained 3 weeks after the onset of the symptoms. Migraine with aura was considered to be the cause of the lesion. To our knowledge the present case is the first report of a pediatric patient with a diagnosis of migraine with aura presenting with hemiparesis and encephalopathy. A diagnosis of transient lesion of the corpus callosum should be suspected in patients with migraine with aura presenting with hemiparesis and encephalopathy. A mild course and a good prognosis might be expected in the presence of a splenial lesion of the corpus callosum.

  12. Late onset aura may herald cerebral amyloid angiopathy: A case report.

    Science.gov (United States)

    Samanci, Bedia; Coban, Oguzhan; Baykan, Betul

    2016-09-01

    Although migraine usually begins in the early decades of life, late onset of migraine with aura is occasionally observed and can occur without headache, causing confusion in the differential diagnosis. A 72-year-old man presented with recurrent episodes of visual aura lasting for 20 minutes. These episodes had started at 57 years of age and were only once accompanied by a severe headache. Magnetic resonance imaging revealed changes in the periventricular white matter, left occipital haemorrhage and subcortical haemosiderin deposits, compatible with cerebral amyloid angiopathy. Previous treatment with antiplatelet drugs was discontinued. His episodes of visual aura stopped on treatment with lamotrigine and add-on treatment with verapamil. In patients with a late onset of migraine aura, doctors must consider other under-recognized causes of transient neurological symptoms, such as cerebral amyloid angiopathy. Blood-sensitive magnetic resonance imaging sequences are the best tool for the early detection of an underlying pathology and therefore treatment with antiplatelet/anticoagulant drugs should be avoided as this may increase the risk of haemorrhage. © International Headache Society 2015.

  13. Inimlik eksitus Lätis saatis kontrolli kõik Aura mahlajoogid / Hindrek Riikoja

    Index Scriptorium Estoniae

    Riikoja, Hindrek

    2006-01-01

    Tartu Õlletehase liiga suure säilitusaine sisalduse tõttu Lätis müügilt kõrvaldatud Aura Arcticu mahlajoogid tõid kaasa kogu tootesarja ulatusliku kontrolli. Rohkem eksimusi uuring ei tuvastanud. Lisa: Bensoehape

  14. Mission Status for Earth Science Constellation MOWG Meeting at KSC: EOS Aura

    Science.gov (United States)

    Fisher, Dominic

    2017-01-01

    This will be presented at the Earth Science Constellation Mission Operations Working Group (MOWG) meeting at KSC (Kennedy Space Center) in December 2017 to discus EOS (Earth Observing System) Aura status. Reviewed and approved by Eric Moyer, ESMO (Earth Sciences Mission Operations) Deputy Project Manager.

  15. Scent of aura? Clinical features of olfactory hallucinations during a migraine attack (OHM).

    Science.gov (United States)

    Mainardi, Federico; Rapoport, Alan; Zanchin, Giorgio; Maggioni, Ferdinando

    2017-02-01

    Introduction Olfactory hallucination during a migraine attack (OHM) is a rare phenomenon. At present, it is not considered a manifestation of migraine aura. Material and methods The clinical features of OHM were collected in 11 patients. Results Of the 11 patients, 10 had migraine without aura and one migraine with aura associated with OHM. Mean age at onset of headache and at appearance of OHM were respectively 17.8 and 32.3 years. Migraine average frequency was 3.9 attacks/month, 19% of them being associated with OHM. The temporal pattern of OHM maintained the same characteristics in the different attacks. OHM onset was described as sudden ( n = 5), gradual ( n = 3), initially sudden and then gradual ( n = 2), or developing in a few seconds ( n = 1). In most of the cases ( n = 8) OHM lasted from 3 to 10 minutes; it persisted during the pain phase (2-24 hours) in only three patients. The type of the perceived smell was invariably constant in nine patients. Conclusion OHM features fulfilled the ICHD-III beta criteria for typical aura.

  16. Aura OMI observations of regional SO2 and NO2 pollution changes from 2005 to 2015

    NARCIS (Netherlands)

    Krotkov, Nickolay A.; McLinden, Chris A.; Li, Can; Lamsal, Lok N.; Celarier, Edward A.; Marchenko, Sergey V.; Swartz, William H.; Bucsela, Eric J.; Joiner, Joanna; Duncan, Bryan N.; Boersma, K. Folkert; Veefkind, J.P.; Levelt, Pieternel Felicitas; Fioletov, Vitali E.; Dickerson, Russell R.; He, Hao; Lu, Zifeng; Streets, David G.

    2016-01-01

    The Ozone Monitoring Instrument (OMI) onboard NASA's Aura satellite has been providing global observations of the ozone layer and key atmospheric pollutant gases, such as nitrogen dioxide (NO2) and sulfur dioxide (SO2), since October 2004. The data products from the same instrument provide

  17. A case of strictly unilateral migraine without aura transformed in an episodic hemicrania continua.

    Science.gov (United States)

    Terlizzi, Rossana; Cevoli, Sabina; Nicodemo, Marianna; Pierangeli, Giulia; Grimaldi, Daniela; Cortelli, Pietro

    2011-02-01

    According to the diagnostic criteria of International Headache Society classification, hemicrania continua is a strictly unilateral continuous headache of moderate intensity with painful exacerbations associated with ipsilateral autonomic signs without pain-free periods. We report a case of a 42-year-old woman suffered of a remitting form of hemicrania continua evolved from a strictly unilateral migraine without aura.

  18. Type of preoperative aura may predict postsurgical outcome in patients with temporal lobe epilepsy and mesial temporal sclerosis.

    Science.gov (United States)

    Asadi-Pooya, Ali A; Nei, Maromi; Sharan, Ashwini; Sperling, Michael R

    2015-09-01

    As the initial symptoms of epileptic seizures, many types of auras have significant localizing or lateralizing value. In this study, we hypothesized that the type of aura may predict postsurgical outcome in patients with medically refractory temporal lobe epilepsy (TLE) and mesial temporal sclerosis (MTS). In this retrospective study, all patients with a clinical diagnosis of medically refractory TLE due to unilateral mesial temporal sclerosis who underwent epilepsy surgery at the Jefferson Comprehensive Epilepsy Center were recruited. Patients were prospectively registered in a database from 1986 through 2014. Postsurgical outcome was classified into two groups: seizure freedom or relapse. Outcome was compared between seven groups of patients according to their preoperative auras. Two hundred thirty-seven patients were studied. The chance of becoming free of seizures after surgery in patients with abdominal aura was 65.1%, while in other patients, this was 43.3% (P=0.01). In two-by-two comparisons, no other significant differences were observed. Patients with medically refractory TLE-MTS who reported abdominal auras preceding their seizures fared better postoperatively with regard to seizure control compared with those who did not report auras, which may indicate bitemporal dysfunction, and to patients with other auras, which may indicate a widespread epileptogenic zone in the latter group of patients. Copyright © 2015 Elsevier Inc. All rights reserved.

  19. La "visión del aura" como experiencia alucinatoria en individuos no-clinicos The aura experience as cognitive perceptual schizotypy in non-clinical population

    Directory of Open Access Journals (Sweden)

    Alejandro Parra

    2008-12-01

    Full Text Available Individuos que dicen ver el aura/energía en forma espontánea también tienden a tener un nivel más elevado de actividad imaginativa/fantaseosa o de propensidad a la fantasía. Hay indicadores que muestran que quienes experimentan alta capacidad de absorción, usualmente experimentan también diversas formas parasomáticas, alucinaciones táctiles, y sensaciones de energías sutiles, asi como también ideación esquizotípica, error perceptual, y mayor sinestesia. El objetivo es correlacionar puntajes de absorción psicológica, disociación, propensidad a la fantasía, intensidad de la imaginería, y tendencia a la esquizotipia en individuos que dicen ver el aura (N=83 en comparación con un grupo sin experiencias (N=503. La muestra incluyó 678 estudiantes de psicología de ambos sexos, 449 (76,5% mujeres y 139 (23,5% varones, cuya rango etario es de 17 y 57 años (Media=25,54; SD=7,22 residentes en la Ciudad de Buenos Aires y alrededores. Ningun estudiante recibió compensación económica. Respecto a la experiencia de ver el aura, se formuló la pregunta de la siguiente manera: "¿Ha tenido alguna experiencia usted es capaz de ver campos de energia o luces alrededor del cuerpo de una persona? (si duda, por favor, responda no". Si la respuesta es afirmativa, la pregunta también mapea tres dimensiones de la experiencia: frecuencia de la experiencia, explicación subjetiva (racional, desconocida y paranormal de la experiencia, y positivo o negativo impacto (emocional en una escala Likert, siendo 1 positivo y 7 negativo. Los resultados muestran mayor nivel de esquizotipia cognitivo perceptual en comparación con quienes no tienen la experiencia. Posiblemente, estas personas tienen mucha más intensa vida imaginativa. Esta experiencia no necesariamente posee un significado psicopatológico para el individuo; quienes ven el aura simplemente podrían ser sensibles a las experiencias perceptuales anómalas.Individuals who claim being able to

  20. Aura-biomes are present in the water layer above coral reef benthic macro-organisms

    Directory of Open Access Journals (Sweden)

    Kevin Walsh

    2017-08-01

    Full Text Available As coral reef habitats decline worldwide, some reefs are transitioning from coral- to algal-dominated benthos with the exact cause for this shift remaining elusive. Increases in the abundance of microbes in the water column has been correlated with an increase in coral disease and reduction in coral cover. Here we investigated how multiple reef organisms influence microbial communities in the surrounding water column. Our study consisted of a field assessment of microbial communities above replicate patches dominated by a single macro-organism. Metagenomes were constructed from 20 L of water above distinct macro-organisms, including (1 the coral Mussismilia braziliensis, (2 fleshy macroalgae (Stypopodium, Dictota and Canistrocarpus, (3 turf algae, and (4 the zoanthid Palythoa caribaeorum and were compared to the water microbes collected 3 m above the reef. Microbial genera and functional potential were annotated using MG-RAST and showed that the dominant benthic macro-organisms influence the taxa and functions of microbes in the water column surrounding them, developing a specific “aura-biome”. The coral aura-biome reflected the open water column, and was associated with Synechococcus and functions suggesting oligotrophic growth, while the fleshy macroalgae aura-biome was associated with Ruegeria, Pseudomonas, and microbial functions suggesting low oxygen conditions. The turf algae aura-biome was associated with Vibrio, Flavobacterium, and functions suggesting pathogenic activity, while zoanthids were associated with Alteromonas and functions suggesting a stressful environment. Because each benthic organism has a distinct aura-biome, a change in benthic cover will change the microbial community of the water, which may lead to either the stimulation or suppression of the recruitment of benthic organisms.

  1. Aura-biomes are present in the water layer above coral reef benthic macro-organisms.

    Science.gov (United States)

    Walsh, Kevin; Haggerty, J Matthew; Doane, Michael P; Hansen, John J; Morris, Megan M; Moreira, Ana Paula B; de Oliveira, Louisi; Leomil, Luciana; Garcia, Gizele D; Thompson, Fabiano; Dinsdale, Elizabeth A

    2017-01-01

    As coral reef habitats decline worldwide, some reefs are transitioning from coral- to algal-dominated benthos with the exact cause for this shift remaining elusive. Increases in the abundance of microbes in the water column has been correlated with an increase in coral disease and reduction in coral cover. Here we investigated how multiple reef organisms influence microbial communities in the surrounding water column. Our study consisted of a field assessment of microbial communities above replicate patches dominated by a single macro-organism. Metagenomes were constructed from 20 L of water above distinct macro-organisms, including (1) the coral Mussismilia braziliensis , (2) fleshy macroalgae ( Stypopodium , Dictota and Canistrocarpus ), (3) turf algae, and (4) the zoanthid Palythoa caribaeorum and were compared to the water microbes collected 3 m above the reef. Microbial genera and functional potential were annotated using MG-RAST and showed that the dominant benthic macro-organisms influence the taxa and functions of microbes in the water column surrounding them, developing a specific "aura-biome". The coral aura-biome reflected the open water column, and was associated with Synechococcus and functions suggesting oligotrophic growth, while the fleshy macroalgae aura-biome was associated with Ruegeria , Pseudomonas, and microbial functions suggesting low oxygen conditions. The turf algae aura-biome was associated with Vibrio, Flavobacterium, and functions suggesting pathogenic activity, while zoanthids were associated with Alteromonas and functions suggesting a stressful environment. Because each benthic organism has a distinct aura-biome, a change in benthic cover will change the microbial community of the water, which may lead to either the stimulation or suppression of the recruitment of benthic organisms.

  2. A Comprehensive Analysis of Articles Retracted Between 2004 and 2013 from Biomedical Literature – A Call for Reforms

    Directory of Open Access Journals (Sweden)

    Harkanwal Preet Singh

    2014-07-01

    Full Text Available Science is a dynamic subject and it was never free of misconduct or bad research. Indeed, the scientific method itself is intended to overcome mistakes and misdeeds. So, we aimed to assess various factors associated with retraction of scientific articles from 2004 to 2013. Data were retrieved from PubMed and Medline using the keywords retraction of articles, retraction notice, and withdrawal of article in April 2014 to detect articles retracted from 2004 to 2013. Statistical analysis was carried out using t-test and Karl Pearson's correlation coefficient. Results showed that a total of 2343 articles were retracted between 2004 and 2013, and original articles followed by case reports constituted major part of it. Time interval between submission and retraction of article has reduced in recent times. Impact factor and retraction do not have any significant correlation. We conclude that although retraction of articles is a rare event, its constant rise in scientific literature is quite worrisome. It is still unclear whether misconduct/mistakes in articles are increasing hastily or the articles are retracted at a rapid rate in recent times. So, it should be considered as an urgent issue and it is the responsibility of journal editors to track misconduct by following Committee on Publication Ethics (COPE guidelines and making an effective strategy.

  3. Self-concept evaluation and migraine without aura in childhood

    Directory of Open Access Journals (Sweden)

    Esposito M

    2013-08-01

    Full Text Available Maria Esposito,1 Beatrice Gallai,2 Lucia Parisi,3 Laura Castaldo,1 Rosa Marotta,4 Serena Marianna Lavano,4 Giovanni Mazzotta,5 Michele Roccella,3 Marco Carotenuto11Center for Childhood Headache, Clinic of Child and Adolescent Neuropsychiatry, Department of Mental Health, Physical and Preventive Medicine, Second University of Naples, Naples, Italy; 2Unit of Child and Adolescent Neuropsychiatry, University of Perugia, Perugia, Italy; 3Child Neuropsychiatry, Department of Psychology, University of Palermo, Palermo, Italy; 4Department of Psychiatry, "Magna Graecia" University of Catanzaro, Catanzaro, Italy; 5Unit of Child and Adolescent Neuropsychiatry, AUSL Umbria 2, Terni, ItalyIntroduction: Self-esteem is related to the broadly understood concept of self-schemas and is a crucial mechanism for a correct psychological development in children and adolescents. The impact of the many psychological difficulties linked to the migraine without aura (MoA and recurrent headache attacks, such as anger and separation anxiety, on self-esteem has not yet been well investigated. The aims of the present study were to assess self-esteem levels in an objective way and to verify their possible relationship and correlation with the frequency and intensity of migraine attacks, in a population of children and adolescents affected by MoA.Methods: The study population was comprised of 185 children (88 males [M], 97 females [F] aged between 6 and 12 years (mean 9.04 ± 2.41 years referred consecutively for MoA to the Center for Childhood Headache, Clinic of Child and Adolescent Neuropsychiatry, Second University of Naples and of 203 healthy controls (95 M, 108 F with mean age 9.16 ± 2.37 years, recruited from schools in Campania. The monthly headache frequency and the mean headache duration were assessed from daily headache diaries kept by all the children, and MoA intensity was assessed on a VAS (visual analog scale. To further evaluate their level of self-concept, all

  4. Comparison of anchorage capacity between implant and headgear during anterior segment retraction.

    Science.gov (United States)

    Li, F; Hu, H K; Chen, J W; Liu, Z P; Li, G F; He, S S; Zou, S J; Ye, Q S

    2011-09-01

    To compare the anchorage effects of the implants and the headgear for patients with anterior teeth retraction in terms of incisor retraction, anchorage loss, inclination of maxillary incisors, positional change of maxillary basal bone, and treatment duration. An electronic search for relative randomized controlled trials (RCTs) prospective and retrospective controlled trials was done through the Cochrane Central Register of Controlled Trials (CENTRAL), PubMed, Embase, Medline, and CNKI, regardless of language of study. Study selection, methodological quality assessment, and data extraction were performed by two reviewers independently. Meta-analysis was performed when possible; otherwise descriptive assessment was done. The search yielded 35 articles, of which eight met the inclusion criteria and were categorized into five groups according to types of intervention. For the midpalatal implant, the anchorage loss was much less than for the headgear group, with insignificant differences in terms of anterior teeth retraction, maxillary incisor inclination, positional change of basal bone, and treatment duration. For the mini-implant, greater anterior teeth retraction and less anchorage loss were demonstrated, with inconsistent results for the other measures. For the onplant, less anchorage loss was noted, with insignificant differences for the other measures. The skeletal anchorage of the midpalatal implant, mini-implant, and onplant offer better alternatives to headgear, with less anchorage loss and more anterior teeth retraction. There were inconsistent results from the included studies in terms of maxillary incisor inclination, positional change of maxillary basal bone, and treatment duration. More qualified RCTs are required to provide clear recommendations.

  5. A novel magnetic-driven tissue retraction device for minimally invasive surgery.

    Science.gov (United States)

    Brancadoro, Margherita; Tognarelli, Selene; Ciuti, Gastone; Menciassi, Arianna

    2017-02-01

    The purpose of this work is to design and validate an innovative magnetic-based device for tissue retraction for minimally invasive surgery. An intra-abdominal magnetic module is coupled with an extracorporeal system for establishing a stable attraction, and consequently a reliable tissue retraction. Once the retractor has been inserted into the abdomen, tissue retraction is not constrained by a fixed access port, thus guaranteeing a more flexible, safer and less invasive operation. The intra-abdominal unit is composed of an axial permanent magnet attached to a stainless-steel non-magnetic alligator clip by a traditional suturing thread. A miniaturized mechanism to adjust the length of the suturing thread for lengthening or shortening the distance between the tissue grasper and the internal magnetic unit is included. A multiphysics approach assured a dedicated design that thoroughly fulfills anatomical, physiological and engineering constraints. System functionalities were demonstrated both in in-vitro and ex-vivo conditions, reaching good results and promising outcomes in terms of effectiveness and maneuverability. The retractor was successfully tested in an animal model, carrying out a whole retraction procedure. The proposed retraction system resulted to be intuitive, reliable, robust and easy to use, representing a suitable device for MIS procedures.

  6. Gingival Retraction Methods for Fabrication of Fixed Partial Denture: Literature Review

    Directory of Open Access Journals (Sweden)

    Safari S

    2016-06-01

    Full Text Available Fixed dental prosthesis success requires appropriate impression taking of the prepared finish line. This is critical in either tooth supported fixed prosthesis (crown and bridge or implant supported fixed prosthesis (solid abutment. If the prepared finish line is adjacent to the gingival sulcus, gingival retraction techniques should be used to decrease the marginal discrepancy among the restoration and the prepared abutment. Accurate marginal positioning of the restoration in the prepared finish line of the abutment is required for therapeutic, preventive and aesthetic purposes. In this article, conventional and modern methods of gingival retraction in the fixed tooth supported prosthesis and fixed implant supported prosthesis are expressed. PubMed and Google Scholar databases were searched manually for studies on gingival tissue managements prior to impression making in fixed dental prosthesis since 1975. Conclusions were extracted and summarized. Keywords were impression making, gingival retraction, cordless retraction, and implant. Gingival retraction techniques can be classified as mechanical, chemical or surgical. In this article, different gingival management techniques are discussed.

  7. A Miniature Robot for Retraction Tasks under Vision Assistance in Minimally Invasive Surgery

    Directory of Open Access Journals (Sweden)

    Giuseppe Tortora

    2014-03-01

    Full Text Available Minimally Invasive Surgery (MIS is one of the main aims of modern medicine. It enables surgery to be performed with a lower number and severity of incisions. Medical robots have been developed worldwide to offer a robotic alternative to traditional medical procedures. New approaches aimed at a substantial decrease of visible scars have been explored, such as Natural Orifice Transluminal Endoscopic Surgery (NOTES. Simple surgical tasks such as the retraction of an organ can be a challenge when performed from narrow access ports. For this reason, there is a continuous need to develop new robotic tools for performing dedicated tasks. This article illustrates the design and testing of a new robotic tool for retraction tasks under vision assistance for NOTES. The retraction robots integrate brushless motors to enable additional degrees of freedom to that provided by magnetic anchoring, thus improving the dexterity of the overall platform. The retraction robot can be easily controlled to reach the target organ and apply a retraction force of up to 1.53 N. Additional degrees of freedom can be used for smooth manipulation and grasping of the organ.

  8. Forest management could counteract distribution retractions forced by climate change.

    Science.gov (United States)

    Mair, Louise; Harrison, Philip J; Räty, Minna; Bärring, Lars; Strandberg, Gustav; Snäll, Tord

    2017-07-01

    Climate change is expected to drive the distribution retraction of northern species. However, particularly in regions with a history of intensive exploitation, changes in habitat management could facilitate distribution expansions counter to expectations under climate change. Here, we test the potential for future forest management to facilitate the southward expansion of an old-forest species from the boreal region into the boreo-nemoral region, contrary to expectations under climate change. We used an ensemble of species distribution models based on citizen science data to project the response of Phellinus ferrugineofuscus, a red-listed old-growth indicator, wood-decaying fungus, to six forest management and climate change scenarios. We projected change in habitat suitability across the boreal and boreo-nemoral regions of Sweden for the period 2020-2100. Scenarios varied in the proportion of forest set aside from production, the level of timber extraction, and the magnitude of climate change. Habitat suitabilities for the study species were projected to show larger relative increases over time in the boreo-nemoral region compared to the boreal region, under all scenarios. By 2100, mean suitabilities in set-aside forest in the boreo-nemoral region were similar to the suitabilities projected for set-aside forest in the boreal region in 2020, suggesting that occurrence in the boreo-nemoral region could be increased. However, across all scenarios, consistently higher projected suitabilities in set-aside forest in the boreal region indicated that the boreal region remained the species stronghold. Furthermore, negative effects of climate change were evident in the boreal region, and projections suggested that climatic changes may eventually counteract the positive effects of forest management in the boreo-nemoral region. Our results suggest that the current rarity of this old-growth indicator species in the boreo-nemoral region may be due to the history of intensive

  9. HIRDLS/Aura Level 3 daily gridded 1 x 1 deg. stratospheric columns of NO2 V007

    Data.gov (United States)

    National Aeronautics and Space Administration — HIR3SCOL is the EOS High Resolution Dynamics Limb Sounder (HIRDLS/Aura) level 3 daily gridded 1 x 1 deg. stratospheric columns of NO2 (nitrogen dioxide) data...

  10. MLS/Aura L1 Radiances from Filter Banks for THz V004 (ML1RADT) at GES DISC

    Data.gov (United States)

    National Aeronautics and Space Administration — ML1RADT is the EOS Aura Microwave Limb Sounder (MLS) product containing the level 1 radiances from the filter banks for the GHz radiometers. The data version is 4.2....

  11. MLS/Aura L1 Radiances from Filter Banks for THz V003 (ML1RADT) at GES DISC

    Data.gov (United States)

    National Aeronautics and Space Administration — ML1RADT is the EOS Aura Microwave Limb Sounder (MLS) product containing the level 1 radiances from the filter banks for the THz radiometer. The data version is...

  12. MLS/Aura L1 Radiances from Filter Banks for GHz V004 (ML1RADG) at GES DISC

    Data.gov (United States)

    National Aeronautics and Space Administration — ML1RADG is the EOS Aura Microwave Limb Sounder (MLS) product containing the level 1 radiances from the filter banks for the GHz radiometers. The data version is 4.2....

  13. MLS/Aura L1 Radiances from Filter Banks for GHz V003 (ML1RADG) at GES DISC

    Data.gov (United States)

    National Aeronautics and Space Administration — ML1RADG is the EOS Aura Microwave Limb Sounder (MLS) product containing the level 1 radiances from the filter banks for the GHz radiometers. The data version is...

  14. MLS/Aura Level 2 Hypochlorous Acid (HOCl) Mixing Ratio V004 (ML2HOCL) at GES DISC

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2HOCL is the EOS Aura Microwave Limb Sounder (MLS) standard product for hypochlorous acid derived from radiances measured primarily by the 640 GHz radiometer. The...

  15. MLS/Aura Level 2 Nitric Acid (HNO3) Mixing Ratio V004 (ML2HNO3) at GES DISC

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2HNO3 is the EOS Aura Microwave Limb Sounder (MLS) standard product for nitric acid derived from radiances measured by the 240 GHz radiometer at and below 10 hPa,...

  16. MLS/Aura Level 2 Hypochlorous Acid (HOCl) Mixing Ratio V003 (ML2HOCL) at GES DISC

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2HOCL is the EOS Aura Microwave Limb Sounder (MLS) standard product for hypochlorous acid derived from radiances measured primarily by the 640 GHz radiometer. The...

  17. MLS/Aura Level 2 Nitric Acid (HNO3) Mixing Ratio V003 (ML2HNO3) at GES DISC

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2HNO3 is the EOS Aura Microwave Limb Sounder (MLS) standard product for nitric acid derived from radiances measured by the 240 GHz radiometer at and below 10 hPa,...

  18. MLS/Aura Near-Real-Time L2 Sulfur Dioxide (SO2) Mixing Ratio V003

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2SO2_NRT is the EOS Aura Microwave Limb Sounder (MLS) Near-Real-Time (NRT) product for sulfur dioxide (SO2). This product contains daily SO2 profiles taken from...

  19. OMI/Aura Cloud Pressure and Fraction (Raman Scattering) 1-Orbit L2 Swath 13x24 km V003

    Data.gov (United States)

    National Aeronautics and Space Administration — The reprocessed Aura OMI Version 003 Level 2 Cloud Data Product OMCLDRR is made available (in April 2012) to the public from the NASA Goddard Earth Sciences Data and...

  20. MLS/Aura Level 3 Bromine Monoxide (BrO) Daily 10deg Lat Zonal Mean V003

    Data.gov (United States)

    National Aeronautics and Space Administration — ML3DZMBRO is the EOS Aura Microwave Limb Sounder (MLS) daily zonal mean product for bromine monoxide derived from radiances measured by the 640 GHz radiometer. The...

  1. MLS/Aura Near-Real-Time L2 Nitric Acid (HNO3) Mixing Ratio V003

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2HNO3_NRT is the EOS Aura Microwave Limb Sounder (MLS) Near-Real-Time (NRT) product for nitric acid (HNO3). This product contains daily HNO3 profiles taken from...

  2. MLS/Aura L1 Radiances from Digital Autocorrelators V004 (ML1RADD) at GES DISC

    Data.gov (United States)

    National Aeronautics and Space Administration — ML1RADD is the EOS Aura Microwave Limb Sounder (MLS) product containing the level 1 radiances from the digital autocorrelators. The data version is 4.2. Data...

  3. MLS/Aura L1 Radiances from Digital Autocorrelators V003 (ML1RADD) at GES DISC

    Data.gov (United States)

    National Aeronautics and Space Administration — ML1RADD is the EOS Aura Microwave Limb Sounder (MLS) product containing the level 1 radiances from the digital autocorrelators. The data version is 3.3/3.4. Data...

  4. OMI/Aura Ozone (O3) Total Column 1-Orbit L2 Swath 13x24 km V003 NRT

    Data.gov (United States)

    National Aeronautics and Space Administration — The OMI/Aura Level-2 Total Column Ozone Data Product OMTO3 Near Real Time data is made available from the OMI SIPS NASA for the public access. The Ozone Monitoring...

  5. OMI/Aura Global Ground Pixel Corners 1-Orbit L2 Swath 13x24km V003

    Data.gov (United States)

    National Aeronautics and Space Administration — The Version-3 Aura/OMI Pixel Corner Product, OMPIXCOR, is now available from the NASA Goddard Earth Sciences Data and Information Services Center (GES DISC)for the...

  6. HIRDLS/Aura Level 3 Temperature 1deg Lat Zonal Fourier Coefficients V007 (H3ZFCT) at GES DISC

    Data.gov (United States)

    National Aeronautics and Space Administration — The "HIRDLS/Aura Level 3 Temperature Zonal Fourier Coefficients" version 7 data product (H3ZFCT) contains the entire mission (~3 years) of HIRDLS data expressed as...

  7. OMI/Aura Sulphur Dioxide (SO2) Total Column 1-orbit L2 Swath 13x24 km V003

    Data.gov (United States)

    National Aeronautics and Space Administration — The Ozone Monitoring Instrument (OMI) was launched aboard the EOS-Aura satellite on July 15, 2004 (1:38 pm equator crossing time, ascending mode). OMI with its 2600...

  8. MLS/Aura Level 2 Bromine Monoxide (BrO) Mixing Ratio V004 (ML2BRO) at GES DISC

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2BRO is the EOS Aura Microwave Limb Sounder (MLS) standard product for bromine monoxide derived from radiances measured by the 640 GHz radiometer. The data version...

  9. MLS/Aura Level 2 Sulfur Dioxide (SO2) Mixing Ratiio V003 (ML2SO2) at GES DISC

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2SO2 is the EOS Aura Microwave Limb Sounder (MLS) standard product for sulfur dioxide derived from radiances measured by the 240 GHz radiometer. The data version...

  10. MLS/Aura Level 2 Hydrogen Cyanide (HCN) Mixing Ratio V003 (ML2HCN) at GES DISC

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2HCN is the EOS Aura Microwave Limb Sounder (MLS) standard product for hydrogen cyanide derived from radiances measured primarily by the 190 GHz radiometer. The...

  11. MLS/Aura Level 2 Hydrogen Cyanide (HCN) Mixing Ratio V004 (ML2HCN) at GES DISC

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2HCN is the EOS Aura Microwave Limb Sounder (MLS) standard product for hydrogen cyanide derived from radiances measured primarily by the 190 GHz radiometer. The...

  12. Activation of rectus capitis posterior major muscles during voluntary retraction of the head in asymptomatic subjects.

    Science.gov (United States)

    Hallgren, Richard C; Rowan, Jacob J; Bai, Peng; Pierce, Steven J; Shafer-Crane, Gail A; Prokop, Lawrence L

    2014-01-01

    The purpose of this study was to assess levels of electromyographic activity measured from rectus capitis posterior major (RCPM) muscles of asymptomatic subjects as their heads moved from a self-defined neutral position to a retracted position. A 2 × 2 within-subjects factorial research design was used. Disposable, intramuscular electrodes were used to collect electromyographic data from asymptomatic subjects between the ages of 20 and 40 years old. Data analysis was performed using mixed effects β regression models. Activation of RCPM muscles was found to significantly increase (P < .0001) as the head moved from a self-defined neutral position to a retracted position. Rectus capitis posterior major muscle activation levels, measured as a function of head position, have not been previously reported. The findings from this study showed that RCPM muscle activation significantly increases during voluntary retraction of the head. Copyright © 2014 National University of Health Sciences. Published by Elsevier Inc. All rights reserved.

  13. Retracted: Differential expression of microRNAs in myometrium and leiomyomas and regulation by ovarian steroids.

    Science.gov (United States)

    2015-10-01

    The above article, published online on 20 December 2007 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor in Chief, Professor L Popescu and John Wiley and Sons Ltd. The retraction has been requested by the University of Florida, Office of Research, in response to their investigation which concluded fabrication of data in Figures 2, 3 and 4. Reference Pan Q, Luo X, Chegini N. Retracted: differential expression of microRNAs in myometrium and leiomyomas and regulation by ovarian steroids. J Cell Mol Med 12: 227-240. Doi: 10.1111/j.1582-4934.2007.00207.x. Copyright © 2015 Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.

  14. [Study of skin retraction applied to the treatment of skin tumors. Mapping of the human body].

    Science.gov (United States)

    Dumas, P; Benatar, M; Cardot-Leccia, N; Lebreton, E; Chignon-Sicard, B

    2012-04-01

    Skin, the main organ of the human body, is equipped with own biomechanical characteristics, highly variable depending on intra-individual factors (location, weight status, dermatological diseases…) and interindividual (age, sex…). Despite some recent cutometric studies, our review of the literature shows that there is no currently reliable analytical model representing the biomechanical behavior of the skin. Yet, this is a central issue in dermatology surgery, especially in the treatment of skin tumors, for the proper observance of surgical margins. We studied prospectively on 75 resection specimens (about 71 patient(s)), for the treatment of skin lesions tumor suspicious or known malignant or benign. Room dimensions were measured before and 5 minutes after excision, leading us to calculate a ratio of retraction of the skin surface. This retraction was correlated with age, gender, tumor type, and anatomic location of the site of excision. The power of retraction of the skin varies significantly by region of the body. It is maximum in the upper limb (hand excluded) and in the cervical region. At the cephalic region, skin of the ear and periorbital skin have capacities of important early retraction. Unlike the lower limb (foot excluded), the back skin of the nose and face appear to be a minimum of shrinkage. Age also seems to change on that capacity shrinkage, sex would have no influence. Our study confirms the variations in the ability of skin retraction based on a number of factors. In dermato-oncology, that power retraction could cause significant differences between clinical surgical margins and final pathologist margins. We believe it must be taken into account by the couple surgeon-pathologist, especially in the context of invasive and/or recurrent tumors. Copyright © 2012. Published by Elsevier SAS.

  15. Probabilistic Design Methodology and its Application to the Design of an Umbilical Retract Mechanism

    Science.gov (United States)

    Onyebueke, Landon; Ameye, Olusesan

    2002-01-01

    A lot has been learned from past experience with structural and machine element failures. The understanding of failure modes and the application of an appropriate design analysis method can lead to improved structural and machine element safety as well as serviceability. To apply Probabilistic Design Methodology (PDM), all uncertainties are modeled as random variables with selected distribution types, means, and standard deviations. It is quite difficult to achieve a robust design without considering the randomness of the design parameters which is the case in the use of the Deterministic Design Approach. The US Navy has a fleet of submarine-launched ballistic missiles. An umbilical plug joins the missile to the submarine in order to provide electrical and cooling water connections. As the missile leaves the submarine, an umbilical retract mechanism retracts the umbilical plug clear of the advancing missile after disengagement during launch and retrains the plug in the retracted position. The design of the current retract mechanism in use was based on the deterministic approach which puts emphasis on factor of safety. A new umbilical retract mechanism that is simpler in design, lighter in weight, more reliable, easier to adjust, and more cost effective has become desirable since this will increase the performance and efficiency of the system. This paper reports on a recent project performed at Tennessee State University for the US Navy that involved the application of PDM to the design of an umbilical retract mechanism. This paper demonstrates how the use of PDM lead to the minimization of weight and cost, and the maximization of reliability and performance.

  16. Modeling length-tension properties of RCPm muscles during voluntary retraction of the head.

    Science.gov (United States)

    Hallgren, Richard C

    2014-08-01

    Head retraction exercises are one of several commonly used clinical tools that are used to assess and treat patients with head and neck pain and to aid in restoration of a normal neutral head posture. Retraction of the head results in flexion of the occipitoatlantal (OA) joint and stretching of rectus capitis posterior minor (RCPm) muscles. The role that retraction of the head might have in treating head and neck pain patients is currently unknown. RCPm muscles arise from the posterior tubercle of the posterior arch of C1 and insert into the occipital bone inferior to the inferior nuchal line and lateral to the midline. RCPm muscles are the only muscles that attach to the posterior arch of C1. The functional role of RCPm muscles has not been clearly defined. The goal of this project was to develop a three-dimensional, computer-based biomechanical model of the posterior aspect of the OA joint. This model should help clarify why voluntary head retraction exercises seem to contribute to the resolution of head and neck pain and restoration of a normal head posture in some patients. The model documents that length-tension properties of RCPm muscles are significantly affected by variations in the physical properties of the musculotendonous unit. The model suggests that variations in the cross sectional area of RCPm muscles due to pathologies that weaken the muscle, such as muscle atrophy, may reduce the ability of these muscles to generate levels of force that are necessary for the performance of normal, daily activities. The model suggests that the main benefit of the initial phase of head retraction exercises may be to strengthen RCPm muscles through eccentric contractions, and that the main benefit of the final phase of retraction may be to stretch the muscles as the final position is held. Copyright © 2014 Elsevier Ltd. All rights reserved.

  17. Reduced fractional anisotropy of corpus callosum modulates inter-hemispheric resting state functional connectivity in migraine patients without aura.

    Science.gov (United States)

    Yuan, Kai; Qin, Wei; Liu, Peng; Zhao, Ling; Yu, Dahua; Zhao, Limei; Dong, Minghao; Liu, Jixin; Yang, Xuejuan; von Deneen, Karen M; Liang, Fanrong; Tian, Jie

    2012-01-01

    Diffusion tensor imaging (DTI) study revealed reduced fractional anisotropy (FA) values in the corpus callosum (CC) in migraine patients without aura. Abnormalities in white matter integrity, particularly in the CC, may affect inter-hemispheric resting state functional connectivity (RSFC). Unfortunately, relatively little is known about the alterations in functional interactions between the cerebral hemispheres during resting state in migraine patients without aura, and even less about how the inter-hemispheric RSFC are affected by the abnormalities of the CC. Twenty-one migraine patients without aura and 21 healthy controls participated in this study, age-, sex-, and education-matched. Tract-based spatial statistics (TBSS) was employed to investigate the white matter alterations of the CC. Meanwhile, voxel-mirrored homotopic connectivity (VMHC) was used to compare the inter-hemispheric RSFC differences between the patients and controls. TBSS analysis revealed reduced FA values in the genu and the splenium of CC in patient group. VMHC analysis showed decreased inter-hemispheric RSFC of anterior cingulate cortex (ACC) in migraine patients without aura relative to that of the controls. Furthermore, in migraine patients without aura, the reduced FA values of the genu of CC correlated with the decreased inter-hemispheric RSFC of the ACC. Our findings demonstrated that the migraine patients without aura showed reduced FA values of the genu of CC and decreased inter-hemispheric RSFC of the ACC. The correlation between the above structural and functional changes suggested that the reduced fractional anisotropy (FA) of CC modulates inter-hemispheric VMHC in migraine patients without aura. Our results demonstrated that the VMHC alterations of ACC can reflect the FA changes of the genu of CC in migraine patients without aura.

  18. RETRACTED: A novel membrane-based anti-diabetic action of atorvastatin

    Energy Technology Data Exchange (ETDEWEB)

    Horvath, Emily M.; Tackett, Lixuan [Department of Cellular and Integrative Physiology, Indiana University School of Medicine, Center for Diabetes Research, VanNuys Medical Science, Building Rm 308A, Indianapolis, IN 46202 (United States); Elmendorf, Jeffrey S., E-mail: jelmendo@iupui.edu [Department of Cellular and Integrative Physiology, Indiana University School of Medicine, Center for Diabetes Research, VanNuys Medical Science, Building Rm 308A, Indianapolis, IN 46202 (United States); Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Center for Diabetes Research, Indianapolis, IN 46202 (United States)

    2008-08-08

    This article has been retracted. Please see Elsevier Policy on Article Withdrawal ((http://www.elsevier.com/locate/withdrawalpolicy)). Reason: The editors would like to confirm the retraction of this paper at the request of the authors. One of the authors, Emily M. Horvath, admitted to altering data in two of the figures. Specifically in Figures 2, and 4A, some of the values were incorrectly reported for the radioactive glucose uptake assays. None of the other authors associated with this publication were aware of the data manipulation. The authors sincerely regret if this has caused problems with investigators that have used this information experimentally.

  19. Attenuation of the Type IV Pilus Retraction Motor Influences Neisseria gonorrhoeae Social and Infection Behavior.

    Science.gov (United States)

    Hockenberry, Alyson M; Hutchens, Danielle M; Agellon, Al; So, Magdalene

    2016-12-06

    Retraction of the type IV pilus (Tfp) mediates DNA uptake, motility, and social and infection behavior in a wide variety of prokaryotes. To date, investigations into Tfp retraction-dependent activities have used a mutant deleted of PilT, the ATPase motor protein that causes the pilus fiber to retract. ΔpilT cells are nontransformable, nonmotile, and cannot aggregate into microcolonies. We tested the hypothesis that these retraction-dependent activities are sensitive to the strength of PilT enzymatic activity by using the pathogen Neisseria gonorrhoeae as a model. We constructed an N. gonorrhoeae mutant with an amino acid substitution in the PilT Walker B box (a substitution of cysteine for leucine at position 201, encoded by pilTL201C). Purified PilTL201C forms a native hexamer, but mutant hexamers hydrolyze ATP at half the maximal rate. N. gonorrhoeae pilTL201C cells produce Tfp fibers, crawl at the same speed as the wild-type (wt) parent, and are equally transformable. However, the social behavior of pilTL201C cells is intermediate between the behaviors of wt and ΔpilT cells. The infection behavior of pilTL201C is also defective, due to its failure to activate the epidermal growth factor receptor (EGFR)-heparin-binding EGF-like growth factor (HB-EGF) pathway. Our study indicates that pilus retraction, per se, is not sufficient for N. gonorrhoeae microcolony formation or infectivity; rather, these activities are sensitive to the strength of PilT enzymatic activity. We discuss the implications of these findings for Neisseria pathogenesis in the context of mechanobiology. Type IV pili are fibers expressed on the surface of many bacteria. Neisseria gonorrhoeae cells crawl, take up DNA, and communicate with each other and with human cells by retracting these fibers. Here, we show that an N. gonorrhoeae mutant expressing an enzymatically weakened type IV pilus retraction motor still crawls and takes up DNA normally. However, mutant cells exhibit abnormal social

  20. Retraction statement: Advances in the physiological and pathological implications of cholesterol.

    Science.gov (United States)

    2015-08-01

    The above article, published online on 28 February 2013 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor in Chief, William Foster, and John Wiley and Sons Ltd. The retraction has been agreed due to the publication of a similar paper by the same authors (with the exclusion of P Mardones) in Frontiers in Bioscience in January 2014. The authors believed that they had taken the necessary steps to withdraw their paper from Frontiers in Bioscience before they submitted to Biological Reviews in June 2012. © 2015 Cambridge Philosophical Society.

  1. Retracted: Bacteria diversity overview and endoglucanase assessment from Himalayan Tapovan geothermal spring.

    Science.gov (United States)

    Sahoo, Jitendra Kumar; Navani, Naveen Kumar; Pathania, Ranjana

    2015-08-25

    The above article from the Journal of Basic Microbiology, published online on 25 August 2015 in Wiley Online Library as Early View (http://onlinelibrary.wiley.com/doi/10.1002/jobm.201500135/pdf), has been retracted by agreement between Naveen Kumar Navani and Ranjana Pathania, the Editor-in-Chief and Wiley-VCH GmbH & Co. KGaA. The retraction has been agreed because the article has been submitted and approved for publication by Jitendra Kumar Sahoo without consent in any form by the named co-authors Naveen Kumar Navani and Ranjana Pathania. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  2. Functional and effective connectivity in EEG alpha and beta bands during intermittent flash stimulation in migraine with and without aura.

    Science.gov (United States)

    de Tommaso, Marina; Stramaglia, Sebastiano; Marinazzo, Daniele; Trotta, Gabriele; Pellicoro, Mario

    2013-08-01

    This research was a case-control study to evaluate functional and effective connectivity patterns in ongoing electroencephalography (EEG) under repetitive photic stimulation in the interictal phase of migraine patients with and without aura compared to nonmigraine controls. EEG was recorded by six scalp electrodes from 19 migraine without aura patients (MO), 19 migraine with aura patients (MA) and 11 healthy subjects (control group (N)). Flash stimuli were presented at 9-27 Hz frequencies. Phase synchronization after Hilbert transform and Granger causality were evaluated filtering the EEG in alpha and beta bands. Phase synchronization increased in alpha band in MO, and decreased in beta band in MA, with respect to controls. The intensity of directed interactions in beta band, revealed by Granger causality, increased in MA compared to both MO patients and controls. There were clear differences in ongoing EEG under visual stimulation, which emerged between the two forms of migraine, probably subtended by increased cortical activation in migraine with aura, and compensatory phenomena of reduced connectivity and functional networks segregation, occurring in patients not experiencing aura symptoms. Further investigation may confirm whether the clinical manifestation of aura symptoms is subtended by a peculiar neuronal connectivity pattern.

  3. Maintaining Aura's Orbit Requirements While Performing Orbit Maintenance Maneuvers Containing an Orbit Normal Delta-V Component

    Science.gov (United States)

    Johnson, Megan R.; Petersen, Jeremy D.

    2014-01-01

    The Earth Observing System (EOS) Afternoon Constellation consists of five member missions (GCOM-W1, Aqua, CALIPSO, CloudSat, and Aura), each of which maintain a frozen, sun-synchronous orbit with a 16-day repeating ground track that follows the Worldwide Reference System-2 (WRS-2). Under nominal science operations for Aura, the propulsion system is oriented such that the resultant thrust vector is aligned 13.493 degrees away from the velocity vector along the yaw axis. When performing orbit maintenance maneuvers, the spacecraft performs a yaw slew to align the thrust vector in the appropriate direction. A new Drag Make Up (DMU) maneuver operations scheme has been implemented for Aura alleviating the need for the 13.493 degree yaw slew. The focus of this investigation is to assess the impact that no-slew DMU maneuver operations will have on Aura's Mean Local Time (MLT) which drives the required along track separation between Aura and the constellation members, as well as Aura's frozen orbit properties, eccentricity and argument of perigee. Seven maneuver strategies were analyzed to determine the best operational approach. A mirror pole strategy, with maneuvers alternating at the North and South poles, was implemented operationally to minimize impact to the MLT. Additional analysis determined that the mirror pole strategy could be further modified to include frozen orbit maneuvers and thus maintain both MLT and the frozen orbit properties under noslew operations.

  4. Magnetic resonance imaging arterial-spin-labelling perfusion alterations in childhood migraine with atypical aura: a case-control study.

    Science.gov (United States)

    Boulouis, Grégoire; Shotar, Eimad; Dangouloff-Ros, Volodia; Grévent, David; Calmon, Raphaël; Brunelle, Francis; Naggara, Olivier; Kossorotoff, Manoelle; Boddaert, Nathalie

    2016-09-01

    Atypical migraine with aura can be challenging to diagnose. Arterial-spin-labelling (ASL) is able to non-invasively quantify brain perfusion. Our aim was to report cerebral blood flow (CBF) alterations using ASL, at the acute phase of atypical migraine with aura in children. Paediatric patients were retrospectively included if (1) referred for acute neurological deficit(s), (2) underwent brain magnetic resonance imaging (MRI) at presentation with ASL sequence, and (3) had subsequent diagnosis of migraine with aura. Neurological symptom-free controls were matched for age. Twenty-eight regions of interest (ROIs) were drawn on CBF maps for each participant/control. Ten patients were included (median age 13y, range 8-16y). Eight of 10 had multiple aura symptoms during the episode. For every patient, CBF was decreased in a brain region consistent with symptoms when MRI was performed less than 14 hours after onset (n=7 patients) and increased if the MRI was performed 17 hours or more after (n=4 MRIs). MRI-ASL appears to be a promising tool for the diagnostic workup and differentials exclusion in paediatric migraine with aura. Constant and time-consistent non-territorial CBF modifications were found in our sample providing additional insight to migraine with aura pathophysiology. The authors encourage implementing this sequence at the acute phase of unexplained paediatric neurological deficits, with or without accompanying headache. © 2016 Mac Keith Press.

  5. On retracting properties and covering homotopy theorem for S-maps into Sχ-cofibrations and Sχ-fibrations

    Directory of Open Access Journals (Sweden)

    Amin Saif

    2016-10-01

    Full Text Available In this paper we generalize the retracting property in homotopy theory for topological semigroups by introducing the notions of deformation S-retraction with its weaker forms and ES-homotopy extension property. Furthermore, the covering homotopy theorems for S-maps into Sχ-fibrations and Sχ-cofibrations are introduced and pullbacks for Sχ-fibrations behave properly.

  6. Retracted article: Khasanov I.F. Modern regional investment policy implementation methods. Statistics and Economics. 2016;(6:114-119. (In Russ.

    Directory of Open Access Journals (Sweden)

    article Editorial

    2017-01-01

    Full Text Available This article by Ildar F. Khasanov has been retracted (i.e. withdrawn from the press by the editor with permission of the publisher.Retracted article due to unformed borrowings (plagiarism.

  7. Timing and topography of cerebral blood flow, aura, and headache during migraine attacks

    DEFF Research Database (Denmark)

    Olesen, J; Friberg, L; Olsen, T S

    1990-01-01

    Ten years of study has resulted in considerable but fragmented knowledge about regional cerebral blood flow in migraine with aura (classic migraine). In the present study, the number of repeatedly studied patients (n = 63) was large enough to determine statistically significant sequences of events...... and statistically significant spatial relations. The first observable event was a decrease of regional cerebral blood flow posteriorly in one cerebral hemisphere. Further development of this pathological process was accompanied by the aura symptoms. Thereafter headache occurred while regional cerebral blood flow...... remained decreased. During the headache phase, regional cerebral blood flow gradually changed from abnormally low to abnormally high without apparent change in headache. In some patients headache disappeared while regional cerebral blood flow remained increased. Although regional cerebral blood flow...

  8. Migraine with aura and risk of silent brain infarcts and white matter hyperintensities: an MRI study.

    Science.gov (United States)

    Gaist, David; Garde, Ellen; Blaabjerg, Morten; Nielsen, Helle H; Krøigård, Thomas; Østergaard, Kamilla; Møller, Harald S; Hjelmborg, Jacob; Madsen, Camilla G; Iversen, Pernille; Kyvik, Kirsten O; Siebner, Hartwig R; Ashina, Messoud

    2016-07-01

    A small number of population-based studies reported an association between migraine with aura and risk of silent brain infarcts and white matter hyperintensities in females. We investigated these relations in a population-based sample of female twins. We contacted female twins ages 30-60 years identified through the population-based Danish Twin Registry. Based on questionnaire responses, twins were invited to participate in a telephone-based interview conducted by physicians. Headache diagnoses were established according to the International Headache Society criteria. Cases with migraine with aura, their co-twins, and unrelated migraine-free twins (controls) were invited to a brain magnetic resonance imaging scan performed at a single centre. Brain scans were assessed for the presence of infarcts, and white matter hyperintensities (visual rating scales and volumetric analyses) blinded to headache diagnoses. Comparisons were based on 172 cases, 34 co-twins, and 139 control subjects. Compared with control subjects, cases did not differ with regard to frequency of silent brain infarcts (four cases versus one control), periventricular white matter hyperintensity scores [adjusted mean difference (95% confidence interval): -0.1 (-0.5 to 0.2)] or deep white matter hyperintensity scores [adjusted mean difference (95% confidence interval): 0.1 (-0.8 to 1.1)] assessed by Scheltens' scale. Cases had a slightly higher total white matter hyperintensity volume compared with controls [adjusted mean difference (95% confidence interval): 0.17 (-0.08 to 0.41) cm(3)] and a similar difference was present in analyses restricted to twin pairs discordant for migraine with aura [adjusted mean difference 0.21 (-0.20 to 0.63)], but these differences did not reach statistical significance. We found no evidence of an association between silent brain infarcts, white matter hyperintensities, and migraine with aura. © The Author (2016). Published by Oxford University Press on behalf of the

  9. Better Asthma Management with Advanced Technology: Creation of an Asthma Utilization Rx Analyzer (AURA) Tool.

    Science.gov (United States)

    Jackson, James H; Gutierrez, Benjamin; Lunacsek, Orsolya E; Ramachandran, Sulabha

    2009-02-01

    With nearly 23 million people affected by asthma each year, optimizing care among patients with persistent disease is a constant challenge for health care providers. The Asthma Utilization Rx Analyzer (AURA) tool enables health plan managers to evaluate quality and resource utilization for its members with asthma by analyzing medical and pharmacy claims. Customizable quality measures allow users of the tool to generate results from specific plans in order to optimize asthma disease management.

  10. Laser hazard analysis for airborne AURA (Big Sky variant) Proteus platform.

    Energy Technology Data Exchange (ETDEWEB)

    Augustoni, Arnold L.

    2004-02-01

    A laser safety and hazard analysis was performed for the airborne AURA (Big Sky Laser Technology) lidar system based on the 2000 version of the American National Standard Institute's (ANSI) Standard Z136.1, for the Safe Use of Lasers and the 2000 version of the ANSI Standard Z136.6, for the Safe Use of Lasers Outdoors. The AURA lidar system is installed in the instrument pod of a Proteus airframe and is used to perform laser interaction experiments and tests at various national test sites. The targets are located at various distances or ranges from the airborne platform. In order to protect personnel, who may be in the target area and may be subjected to exposures, it was necessary to determine the Maximum Permissible Exposure (MPE) for each laser wavelength, calculate the Nominal Ocular Hazard Distance (NOHD), and determine the maximum 'eye-safe' dwell times for various operational altitudes and conditions. It was also necessary to calculate the appropriate minimum Optical Density (ODmin) of the laser safety eyewear used by authorized personnel who may receive hazardous exposures during ground base operations of the airborne AURA laser system (system alignment and calibration).

  11. Alleviation of Brain Hypoperfusion after Preventative Treatment with Lomerizine in an Elderly Migraineur with Aura

    Science.gov (United States)

    Aoyagi, Joe; Ikeda, Ken; Kiyozuka, Tetsuhito; Hirayama, Takehisa; Ishikawa, Yuichi; Sato, Ryuta; Yoshii, Yasuhiro; Kawabe, Kiyokazu; Iwasaki, Yasuo

    2011-01-01

    Previous studies of brain single-photon emission tomography (SPECT) showed changes of regional cerebral blood flow (rCBF) in migraineurs during prodromes or headache attacks. Little is known about how successful medication of migraine prevention can reflect rCBF in migraineurs. We highlighted alternation of brain SPECT findings in a migraineur with aura before and after prophylactic treatment with lomerizine, a calcium channel blocker. A 70-year-old man with migraine developed visual disturbance frequently at walking exercise for the recent 3 months. After this visual attack, a mild-degree of throbbing headache occured occasionally. Brain SPECT using 99mTc-ethyl cysteinate dimer was performed at interictal time of migraine. Brain SPECT before lomerizine treatment revealed hypoperfusion in the frontal, parietal, and occipital regions. He was diagnosed with recurrence of migraine with aura (MA). Lomerizine (10 mg/day, po) was administered for 3 months. MA and visual aura without headache were dramatically improved. Migraine attacks and visual disturbance were not induced at exercise. At 3 months after lomerizine medication, brain SPECT showed remarkable increase of rCBF. These SPECT changes of our patient indicated that antimigraine mechanism of lomerizine could contribute to restoration of cerebral hypoperfusion. PMID:21490733

  12. Alleviation of Brain Hypoperfusion after Preventative Treatment with Lomerizine in an Elderly Migraineur with Aura

    Directory of Open Access Journals (Sweden)

    Joe Aoyagi

    2011-01-01

    Full Text Available Previous studies of brain single-photon emission tomography (SPECT showed changes of regional cerebral blood flow (rCBF in migraineurs during prodromes or headache attacks. Little is known about how successful medication of migraine prevention can reflect rCBF in migraineurs. We highlighted alternation of brain SPECT findings in a migraineur with aura before and after prophylactic treatment with lomerizine, a calcium channel blocker. A 70-year-old man with migraine developed visual disturbance frequently at walking exercise for the recent 3 months. After this visual attack, a mild-degree of throbbing headache occured occasionally. Brain SPECT using 99mTc-ethyl cysteinate dimer was performed at interictal time of migraine. Brain SPECT before lomerizine treatment revealed hypoperfusion in the frontal, parietal, and occipital regions. He was diagnosed with recurrence of migraine with aura (MA. Lomerizine (10 mg/day, po was administered for 3 months. MA and visual aura without headache were dramatically improved. Migraine attacks and visual disturbance were not induced at exercise. At 3 months after lomerizine medication, brain SPECT showed remarkable increase of rCBF. These SPECT changes of our patient indicated that antimigraine mechanism of lomerizine could contribute to restoration of cerebral hypoperfusion.

  13. Hormonal Contraceptives and Migraine With Aura-Is There Still a Risk?

    Science.gov (United States)

    Calhoun, Anne H

    2017-02-01

    Unnecessary confusion still surrounds the use of combined hormonal contraceptives (CHCs) in the setting of migraine with aura (MwA). Clearing this confusion is a key issue for headache specialists, since most women with migraine have menstrual-related migraine (MRM), and some CHCs can prevent this particularly severe migraine. Their use, however, is still restricted by current guidelines due to concerns of increased stroke risk - concerns that originated over half a century ago in the era of high dose contraceptives. Yet studies consistently show that stroke risk is not increased with today's very low dose CHCs containing 20-25 µg ethinyl estradiol (EE), and continuous ultra low-dose formulations (10-15 µg EE) may even reduce aura frequency, thereby potentially decreasing stroke risk. This article clarifies the stroke risk of CHCs and examines their impact on migraine. It also examines how stroke risk is altered by the estrogen content of the CHC, by contributing factors such as smoking, age and hypertension, and by aura frequency. And finally, it puts these risks into a meaningful context with a risk/benefit assessment. © 2016 American Headache Society.

  14. Propagation of errors in citation networks: a study involving the entire citation network of a widely cited paper published in, and later retracted from, the journal Nature

    NARCIS (Netherlands)

    van der Vet, P.E.; Nijveen, Harmen

    2016-01-01

    Background In about one in 10,000 cases, a published article is retracted. This very often means that the results it reports are flawed. Several authors have voiced concerns about the presence of retracted research in the memory of science. In particular, a retracted result is propagated by citing

  15. Propagation of errors in citation networks: a study involving the entire citation network of a widely cited paper published in, and later retracted from, the journal Nature

    NARCIS (Netherlands)

    Vet, Van Der Paul E.; Nijveen, Harm

    2016-01-01

    Background
    In about one in 10,000 cases, a published article is retracted. This very often means that the results it reports are flawed. Several authors have voiced concerns about the presence of retracted research in the memory of science. In particular, a retracted result is propagated by

  16. Crossover between activated reptation and arm retraction mechanisms in entangled rod-coil block copolymers

    Science.gov (United States)

    Wang, Muzhou; Likhtman, Alexei E.; Olsen, Bradley D.

    2015-11-01

    Using a coarse-grained slip-spring model, the dynamics of rod-coil block copolymers is explored over a wide parameter space to fully capture the crossover between the short rod (activated reptation) and long rod (arm retraction) limits. An analytical, closed-form expression for curvilinear diffusion by activated reptation was derived by separating the drag into individual components for the rod and coil block. Curvilinear diffusion in the intermediate rod regime, where both mechanisms are important, was then found to be faster than predicted when both mechanisms are independently combined. The discrepancy in the crossover regime arises because the rod-coil copolymer's exploration of space is not accurately described by either a coil homopolymer (assumed by activated reptation) or a rod homopolymer (assumed by arm retraction). This effect is explored by tracking the rod orientation as the polymer reptates, confirming that the polymer reptates along a path that becomes more rodlike as the rod fraction is increased. Thus, activated reptation under-predicts diffusion because the rod can choose reptation paths that are more extended than the coil homopolymer by renewal of the entanglement tube from the ends. Arm retraction under-predicts diffusion because minor rotations of the rod allow some motion before full retractions of the coil block. Finally, more familiar 3-dimensional center-of-mass diffusion measurements are related to the curvilinear diffusion analysis because the ratio of these two quantities varies smoothly between the coil and rod homopolymer limits as the reptation path becomes more extended.

  17. Retraction of "Women's Preference for Attractive Makeup Tracks Changes in Their Salivary Testosterone".

    Science.gov (United States)

    2016-03-01

    At the request of the authors, the following article has been retracted by the Editor and publishers of Psychological Science:Fisher, C. I., Hahn, A. C., DeBruine, L. M., & Jones, B. C. (2015). Women's preference for attractive makeup tracks changes in their salivary testosterone. Psychological Science, 26, 1958-1964. doi:10.1177/0956797615609900. © The Author(s) 2016.

  18. 77 FR 75189 - Certain Electronic Devices Having a Retractable USB Connector; Termination of an Investigation

    Science.gov (United States)

    2012-12-19

    ... From the Federal Register Online via the Government Publishing Office INTERNATIONAL TRADE COMMISSION Certain Electronic Devices Having a Retractable USB Connector; Termination of an Investigation... viewed on the Commission's electronic docket (EDIS) at http://edis.usitc.gov . Hearing-impaired persons...

  19. Statement of Retraction: Kumar Ajay, Singh Neetu, Gaurav S.S. ...

    African Journals Online (AJOL)

    McRoy

    The Editors and Publisher of the International Journal of Medicine and Biomedical Research wish to state that the following article has been retracted from the journal: Kumar Ajay, Singh. Neetu, Gaurav S.S. Forensic Bioinformatics: An innovative technological advancement in the field of Forensic Medicine and Diagnosis.

  20. Eugregarine trophozoite detachment from the host epithelium via epimerite retraction: Fiction or fact?

    Czech Academy of Sciences Publication Activity Database

    Valigurová, A.; Michalková, V.; Koudela, Břetislav

    2009-01-01

    Roč. 39, č. 11 (2009), s. 1235-1242 ISSN 0020-7519 R&D Projects: GA MŠk LC522 Institutional research plan: CEZ:AV0Z60220518 Keywords : Apicomplexa * epimerite retraction * trophozoite Subject RIV: GJ - Animal Vermins ; Diseases, Veterinary Medicine Impact factor: 3.819, year: 2009

  1. RETRACTED: Investigation into the kinetic behavior of molten aluminum pressureless infiltration into SiC preforms

    Directory of Open Access Journals (Sweden)

    Hassan Sharifi

    2016-10-01

    According to the policy of our Journal, this paper has been retracted because of sheer plagiarism. This paper has been published at the same time in the International Journal of Materials Research (IJMR: http://dx.doi.org/10.3139/146.111422.

  2. Electromyographic activity of rectus capitis posterior minor muscles associated with voluntary retraction of the head.

    Science.gov (United States)

    Hallgren, Richard C; Pierce, Steven J; Prokop, Lawrence L; Rowan, Jacob J; Lee, Angela S

    2014-01-01

    The functional role of rectus capitis posterior minor (RCPm) muscles is not well defined. To the best of our knowledge, electromyographic (EMG) data from RCPm muscles in humans have never been collected and analyzed. To test the null hypothesis that there will be no difference in normalized levels of EMG activity measured from RCPm muscles with the head in a neutral position and with the head in a retracted position. A repeated measures design intended to quantify normalized levels of EMG activity measured from RCPm muscles. Disposable 25-gauge, bipolar fine wire hooked electrodes were used to collect EMG data from both right and left RCPm muscles from 17 asymptomatic subjects. Data were collected while subjects performed five trials with the head maintained in a neutral position; performed three maximal voluntary isometric contraction efforts; performed four trials with the head maintained in a retracted position. Mixed effects beta regression models were used to analyze the data. Normalized EMG activity of RCPm muscles collected with the subject's head held in a retracted position was significantly higher (p<.0001) than normalized EMG activity collected with the subject's head held in a self-selected, neutral position. Rectus capitis posterior minor muscles are active when the head is held in a neutral position and show a significant increase in activity when the head is held in a retracted position. Copyright © 2014 Elsevier Inc. All rights reserved.

  3. Retracted: Nrf2: a novel therapeutic target in fragile X syndrome is modulated by NNZ2566.

    Science.gov (United States)

    Deacon, R M J; Hurley, M J; Rebolledo, C M; Snape, M; Altimiras, F J; Farías, L; Pino, M; Biekofsky, R; Glass, L; Cogram, P

    2017-09-01

    Retraction: "Nrf2: a novel therapeutic target in fragile X syndrome is modulated by NNZ2566" by R. M. J. Deacon, M. J. Hurley, C. M. Rebolledo, M. Snape, F. J. Altimiras, L. Farías, M. Pino, R. Biekofsky, L. Glass and P. Cogram. The above article, from Genes, Brain and Behavior, published online on 12th May 2017 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor in Chief, Andrew Holmes and John Wiley & Sons Ltd. The retraction has been agreed as all authors cannot agree on a revised author order, and at least one author continues to dispute the original order. In this case, the original article is being retracted on the grounds that the journal does not have permission to publish. Reference: Deacon, R. M. J., Hurley, M. J., Rebolledo, C. M., Snape, M., Altimiras, F. J., Farías, L., Pino, M., Biekofsky, R., Glass, L. and Cogram, P. (2017), Nrf2: a novel therapeutic target in fragile X syndrome is modulated by NNZ2566. Genes, Brain and Behavior. doi:10.1111/gbb.12373. © 2017 John Wiley & Sons Ltd and International Behavioural and Neural Genetics Society.

  4. Molecular dynamics simulation of the self-retracting motion of a graphene flake

    Science.gov (United States)

    Popov, Andrey M.; Lebedeva, Irina V.; Knizhnik, Andrey A.; Lozovik, Yurii E.; Potapkin, Boris V.

    2011-12-01

    The self-retracting motion of a graphene flake on a stack of graphene flakes is studied using molecular dynamics simulations. It is shown that in the case when the extended flake is initially rotated to an incommensurate state, there is no barrier to the self-retracting motion of the flake and the flake retracts as fast as possible. If the extended flake is initially commensurate with the other flakes, the self-retracting motion is hindered by potential energy barriers. However, in this case, rotation of the flake to incommensurate states is often observed. Such a rotation is found to be induced by the torque acting on the flake on hills of the potential relief of interaction energy between the flakes. Contrary to carbon nanotubes, telescopic oscillations of the graphene flake are suppressed because of high dynamic friction related to the excitation of flexural vibrations of the flake. This makes graphene promising for the use in fast-responding electromechanical memory cells.

  5. Magnetic resonance imaging findings of the abducens nerves in type 1 Duane's retraction syndrome.

    Science.gov (United States)

    Tuzcu, Esra Ayhan; Bayarogullari, Hanifi; Atci, Nesrin; Basarslan, Fatmagul; Coskun, Mesut; Yilmaz, Cahide; Ilhan, Nilufer; Daglioglu, Mutlu

    2014-05-01

    To investigate nervus abducens and extraocular mucles in patients with Type 1 Duane's retraction syndrome using high-definition magnetic resonance imaging. The study included 10 patients with Type I Duane's retraction syndrome who underwent magnetic resonance imaging (MRI) of the brain and orbits. Overall, 10 cases were included in the study. There were seven women and three men. The mean age was 5.2 years (1-15 years). MRI of the abducens nerve was performed in all cases. Of the cases, the left eye was involved in eight cases, whereas the right eye was involved in two cases. There was no bilateral eye involvement. Among the 10 patients clinically diagnosed as Type 1 Duane's retraction syndrome, the abducens nerve could not be visualized in eight cases, whereas the nerve was hypoplastic in one case and bilateral abducens nerves were present in one case by MRI. The extraocular muscles were normal in all cases on T2 weighted coronal MRI of the orbits. Absence of abducens nerve and normal extraocular muscles was detected in patients with Type 1 Duane's retraction syndrome at the affected side.

  6. Assessment of Eustachian tube function in patients with tympanic membrane retraction and in normal subjects.

    Science.gov (United States)

    Canali, Inesângela; Petersen Schmidt Rosito, Letícia; Siliprandi, Bruno; Giugno, Cláudia; Selaimen da Costa, Sady

    The diagnosis of Eustachian tube dysfunctions is essential for better understanding of the pathogenesis of chronic otitis media. A series of tests to assess tube function are described in the literature; however, they are methodologically heterogeneous, with differences ranging from application protocols to standardization of tests and their results. To evaluate the variation in middle ear pressure in patients with tympanic membrane retraction and in normal patients during tube function tests, as well as to evaluate intra-individual variation between these tests. An observational, contemporary, cross-sectional study was conducted, in which the factor under study was the variation in middle ear pressure during tube function tests (Valsalva maneuver, sniff test, Toynbee maneuver) in healthy patients and in patients with mild and moderate/severe tympanic retraction. A total of 38 patients (76 ears) were included in the study. Patients underwent tube function tests at two different time points to determine pressure measurements after each maneuver. Statistical analysis was performed using SPSS software, version 18.0, considering p-values <0.05 as statistically significant. Mean (standard deviation) age was 11 (2.72) years; 55.3% of patients were male and 44.7% female. The prevalence of type A tympanogram was higher among participants with healthy ears and those with mild retraction, whereas type C tympanograms were more frequent in the moderate/severe retraction group. An increase in middle ear pressure was observed during the Valsalva maneuver at the first time point evaluated in all three groups of ears (p=0.012). The variation in pressure was not significant either for the sniff test or for the Toynbee maneuver at the two time points evaluated (p≥0.05). Agreement between measurements obtained at the two different time points was weak to moderate for all tests in all three groups of ears, and the variations in discrepancy between measurements were higher in ears

  7. Assessment of Eustachian tube function in patients with tympanic membrane retraction and in normal subjects,

    Directory of Open Access Journals (Sweden)

    Inesângela Canali

    Full Text Available Abstract Introduction The diagnosis of Eustachian tube dysfunctions is essential for better understanding of the pathogenesis of chronic otitis media. A series of tests to assess tube function are described in the literature; however, they are methodologically heterogeneous, with differences ranging from application protocols to standardization of tests and their results. Objective To evaluate the variation in middle ear pressure in patients with tympanic membrane retraction and in normal patients during tube function tests, as well as to evaluate intra-individual variation between these tests. Methods An observational, contemporary, cross-sectional study was conducted, in which the factor under study was the variation in middle ear pressure during tube function tests (Valsalva maneuver, sniff test, Toynbee maneuver in healthy patients and in patients with mild and moderate/severe tympanic retraction. A total of 38 patients (76 ears were included in the study. Patients underwent tube function tests at two different time points to determine pressure measurements after each maneuver. Statistical analysis was performed using SPSS software, version 18.0, considering p-values <0.05 as statistically significant. Results Mean (standard deviation age was 11 (2.72 years; 55.3% of patients were male and 44.7% female. The prevalence of type A tympanogram was higher among participants with healthy ears and those with mild retraction, whereas type C tympanograms were more frequent in the moderate/severe retraction group. An increase in middle ear pressure was observed during the Valsalva maneuver at the first time point evaluated in all three groups of ears (p = 0.012. The variation in pressure was not significant either for the sniff test or for the Toynbee maneuver at the two time points evaluated (p ≥ 0.05. Agreement between measurements obtained at the two different time points was weak to moderate for all tests in all three groups of ears, and the

  8. Evaluation of corticotomy-facilitated orthodontics and piezocision in rapid canine retraction.

    Science.gov (United States)

    Abbas, Noha Hussein; Sabet, Noha Ezzat; Hassan, Islam Tarek

    2016-04-01

    The purpose of this study was to evaluate the efficiency of corticotomy-facilitated orthodontics and piezocision in rapid canine retraction. The sample consisted of 20 patients (15-25 years old) with Class II Division 1 malocclusions. The suggested treatment plan was extraction of the maxillary first premolars with subsequent canine retraction. The sample was divided into 2 equal groups. In the first group, 1 side of the maxillary arch was randomly chosen for treatment with corticotomy, and in the second group, piezocision treatment was used. The contralateral sides of both groups served as the controls. Cuts and perforations were performed with a piezotome, and canine retraction was initiated bilaterally in both groups with closed-coil nickel-titanium springs that applied 150 g of force on each side. The following variables were examined over a 3-month follow-up period: rate of canine crown tip, molar anchorage loss, canine rotation, canine inclination, canine root resorption, plaque index, gingival index, probing depth, attachment level, and gingival recession. The rate of canine crown tip was assessed every 2 weeks after the start of canine retraction at 6 time points. The rates of canine crown tip were greater in the experimental sides than in the control sides in both groups. Corticotomies produced greater rates of canine movement than did piezocision at 4 time points. Canine root resorption was greater in the control sides. The remaining studied variables exhibited no differences between the control and the experimental sides. Corticotomy-facilitated orthodontics and piezocision are efficient treatment modalities for accelerating canine retraction. Copyright © 2016 American Association of Orthodontists. Published by Elsevier Inc. All rights reserved.

  9. Miniscrew implant-supported maxillary canine retraction with and without corticotomy-facilitated orthodontics.

    Science.gov (United States)

    Aboul-Ela, Shadw Mohammed Badr El-Din; El-Beialy, Amr Ragab; El-Sayed, Karim Mohamed Fawzy; Selim, Essam Mohamed Nassef; El-Mangoury, Nagwa Helmy; Mostafa, Yehya Ahmed

    2011-02-01

    The purpose of this study was to clinically evaluate miniscrew implant-supported maxillary canine retraction with corticotomy-facilitated orthodontics. The sample consisted of 13 adult patients (5 men, 8 women; mean age, 19 years) exhibiting Class II Division 1 malocclusion with increased overjet requiring the therapeutic extraction of the maxillary first premolars, with subsequent retraction of the maxillary canines. Corticotomy-facilitated orthodontics was randomly assigned to 1 side of the maxillary arch at the canine-premolar region, and the other side served as the control. By using miniscrews as anchorage, canine retraction was initiated via closed nickel-titanium coil springs applying 150 g of force per side. The following variables were examined over a 4-month follow-up period: rate of tooth movement, molar anchorage loss, plaque index, gingival index, probing depth, attachment loss, and gingival recession. The average daily rate of canine retraction was significantly higher on the corticotomy than the control side by 2 times during the first 2 months after the corticotomy surgery. This rate of tooth movement declined to only 1.6 times higher in the third month and 1.06 times higher by the end of the fourth month. No molar anchorage loss occurred during canine retraction on either the operated or the nonoperated side. There was no statistically significant difference between preoperative and postoperative measurements of plaque index, probing depth, attachment loss, and gingival recession. Corticotomy-facilitated orthodontics can be a feasible treatment modality for adults seeking orthodontic treatment with reduced treatment times. Copyright © 2011 American Association of Orthodontists. Published by Mosby, Inc. All rights reserved.

  10. Cell protrusion and retraction driven by fluctuations in actin polymerization: A two-dimensional model.

    Science.gov (United States)

    Ryan, Gillian L; Holz, Danielle; Yamashiro, Sawako; Taniguchi, Daisuke; Watanabe, Naoki; Vavylonis, Dimitrios

    2017-07-28

    Animal cells that spread onto a surface often rely on actin-rich lamellipodial extensions to execute protrusion. Many cell types recently adhered on a two-dimensional substrate exhibit protrusion and retraction of their lamellipodia, even though the cell is not translating. Travelling waves of protrusion have also been observed, similar to those observed in crawling cells. These regular patterns of protrusion and retraction allow quantitative analysis for comparison to mathematical models. The periodic fluctuations in leading edge position of XTC cells have been linked to excitable actin dynamics using a one-dimensional model of actin dynamics, as a function of arc-length along the cell. In this work we extend this earlier model of actin dynamics into two dimensions (along the arc-length and radial directions of the cell) and include a model membrane that protrudes and retracts in response to the changing number of free barbed ends of actin filaments near the membrane. We show that if the polymerization rate at the barbed ends changes in response to changes in their local concentration at the leading edge and/or the opposing force from the cell membrane, the model can reproduce the patterns of membrane protrusion and retraction seen in experiment. We investigate both Brownian ratchet and switch-like force-velocity relationships between the membrane load forces and actin polymerization rate. The switch-like polymerization dynamics recover the observed patterns of protrusion and retraction as well as the fluctuations in F-actin concentration profiles. The model generates predictions for the behavior of cells after local membrane tension perturbations. © 2017 Wiley Periodicals, Inc.

  11. Finite element analysis of rapid canine retraction through reducing resistance and distraction

    Directory of Open Access Journals (Sweden)

    Junjie XUE

    2014-01-01

    Full Text Available Objective: The aims of this study were to compare different surgical approaches to rapid canine retraction by designing and selecting the most effective method of reducing resistance by a three-dimensional finite element analysis. Material and Methods: Three-dimensional finite element models of different approaches to rapid canine retraction by reducing resistance and distraction were established, including maxillary teeth, periodontal ligament, and alveolar. The models were designed to dissect the periodontal ligament, root, and alveolar separately. A 1.5 N force vector was loaded bilaterally to the center of the crown between first molar and canine, to retract the canine distally. The value of total deformation was used to assess the initial displacement of the canine and molar at the beginning of force loading. Stress intensity and force distribution were analyzed and evaluated by Ansys 13.0 through comparison of equivalent (von Mises stress and maximum shear stress. Results: The maximum value of total deformation with the three kinds of models occurred in the distal part of the canine crown and gradually reduced from the crown to the apex of the canine; compared with the canines in model 3 and model 1, the canine in model 2 had the maximum value of displacement, up to 1.9812 mm. The lowest equivalent (von Mises stress and the lowest maximum shear stress were concentrated mainly on the distal side of the canine root in model 2. The distribution of equivalent (von Mises stress and maximum shear stress on the PDL of the canine in the three models was highly concentrated on the distal edge of the canine cervix. . Conclusions: Removal of the bone in the pathway of canine retraction results in low stress intensity for canine movement. Periodontal distraction aided by surgical undermining of the interseptal bone would reduce resistance and effectively accelerate the speed of canine retraction.

  12. Lack of Improvement in Scientific Integrity: An Analysis of WoS Retractions by Chinese Researchers (1997-2016).

    Science.gov (United States)

    Lei, Lei; Zhang, Ying

    2017-09-09

    This study investigated the status quo of article retractions by Chinese researchers. The bibliometric information of 834 retractions from the Web of Science SCI-expanded database were downloaded and analysed. The results showed that the number of retractions increased in the past two decades, and misconduct such as plagiarism, fraud, and faked peer review explained approximately three quarters of the retractions. Meanwhile, a large proportion of the retractions seemed typical of deliberate fraud, which might be evidenced by retractions authored by repeat offenders of data fraud and those due to faked peer review. In addition, a majority of Chinese fraudulent authors seemed to aim their articles which contained a possible misconduct at low-impact journals, regardless of the types of misconduct. The system of scientific evaluation, the "publish or perish" pressure Chinese researchers are facing, and the relatively low costs of scientific integrity may be responsible for the scientific integrity. We suggested more integrity education and severe sanctions for the policy-makers, as well as change in the peer review system and transparent retraction notices for journal administrators.

  13. Retraction: Genistein protects genioglossus myocyte against hypoxia-induced injury through PI3K-Akt and ERK MAPK pathways.

    Science.gov (United States)

    2012-05-01

    RETRACTION: The following article from Journal of Cellular Biochemistry, Genistein protects genioglossus myocyte against hypoxia-induced injury through PI3K-Akt and ERK MAPK pathways by Wanghui Ding and Yuehua Liu, posted online on May 19, 2011 in Wiley Online Library (onlinelibrary.wiley.com), has been retracted by agreement between the authors, the journal Editor in Chief, Dr. Gary S. Stein and Wiley-Liss, Inc. The retraction has been made as authorization to publish was not granted by one of the funding bodies. Copyright © 2012 Wiley Periodicals, Inc.

  14. Field-testing of the ICHD-3 beta/proposed ICD-11 diagnostic criteria for migraine with aura

    DEFF Research Database (Denmark)

    Li, Dana; Christensen, Anne F; Olesen, Jes

    2015-01-01

    abbreviated to fulfill the needs of ICD-11. In the following, only ICHD-3 beta is mentioned, but findings regarding the validity of ICHD-3 beta categories are equally relevant to the forthcoming ICD-11. Here we field-tested the criteria for 1.2 migraine with aura (MA), 1.2.1 migraine with typical aura (MTA......), 1.2.3 hemiplegic migraine, 1.2.2 migraine with brainstem aura, and the alternative criteria A1.2 MA and A1.2.1 MTA. METHODS: Clinical characteristics were systematically and prospectively collected from patients with 1.2.1 MTA, 1.2.4 familial hemiplegic migraine (FHM), 1.2.5 sporadic hemiplegic...... migraine (SHM) and 1.2.6 basilar-type migraine according to ICHD-2 in a cross-sectional study design. A database of 2464 patients with 1.1 migraine without aura and 1.2 migraine with non-hemiplegic aura and a database of 252 hemiplegic migraine patients (1.2.4 FHM or 1.2.5 SHM) was collected. We used SPSS...

  15. Frequency-Dependent Habituation Deficit of the Nociceptive Blink Reflex in Aura With Migraine Headache. Can Migraine Aura Modulate Trigeminal Excitability?

    Science.gov (United States)

    Perrotta, Armando; Anastasio, Maria Grazia; De Icco, Roberto; Coppola, Gianluca; Ambrosini, Anna; Serrao, Mariano; Sandrini, Giorgio; Pierelli, Francesco

    2017-06-01

    To study the influence of the migraine aura on the trigeminal nociception, we investigated the habituation of the nociceptive blink reflex (nBR) R2 responses in aura with migraine headache (AwMH) and comparatively in migraine without aura (MWoA) and healthy subjects (HS). A clear deficit of habituation in trigeminal nociceptive responses has been documented in MWoA; however, similar data in MWA are lacking. Seventeen AwMH, 29 MWoA, and 30 HS were enrolled and a nonrandomized clinical neurophysiological study examining nBR habituation by clinical diagnosis was devised. We delivered a series of 26 electrical stimuli, at different stimulation frequencies (SF) (0.05, 0.1, 0.2, 0.3, 0.5, and 1 Hz), subsequently subdivided in five blocks of five responses for each SF. The mean area values of the second to the fifth block expressed as the percentage of the mean area value of the first block were taken as an index of habituation for each SF. A significant lower mean percentage decrease of the R2 area across all blocks was found at 1, 0.5, 0.3, and 0.2 Hz SF in MWoA and at 0.3 and 0.2 Hz SF in AwMH, when compared to HS. In the most representative fifth block of responses, we found in MWoA vs HS at 1 Hz, 57.0 ± 27.8 vs 30.6 ± 12.0; at 0.5 Hz, 54.8 ± 26.1 vs 32.51 ± 17.7; at 0.3 Hz, 44.7 ± 21.6 vs 27.6 ± 13.2; at 0.2 Hz, 61.3 ± 29.5 vs 32.6 ± 18.0, and in AwMH vs HS at 0.3 Hz, 52.7 ± 24.7 vs 27.6 ± 13.2; at 0.2 Hz, 69.3 ± 38.6 vs 32.6 ± 18.0 as mean ± SD of the R2 area percentage of the first block, respectively. Interestingly, AwMH subjects did not show differences in mean percentage decrease of the R2 area at 1 and 0.5 Hz SF when compared to HS. No differences between groups were found at 0.1 and 0.05 Hz SF. We demonstrated in AwMH a deficit of habituation of the nBR R2 responses after repeated stimulations, although less pronounced than that observed in MWoA of comparable clinical severity. We hypothesize

  16. Retraction - Request that it is necessary to retract paper: Thermal and electrical energy yield analysis of a directly water cooled photovoltaic module DOI:10.2298/TSCI130118144M

    National Research Council Canada - National Science Library

    Editorial

    2016-01-01

    Prof. Dr. Simeon Oka, Editor-in-chief of the journal THERMAL SCIENCE request that it is necessary to retract paper Thermal and electrical energy yield analysis of a directly water cooled photovoltaic module DOI...

  17. OMI/Aura Nitrogen Dioxide (NO2) Total and Tropospheric Column 1-orbit L2 Swath 13x24 km V003

    Data.gov (United States)

    National Aeronautics and Space Administration — The second release of collection 3 OMI/Aura Level-2 NO2 data product OMNO2 is now available (http://disc.gsfc.nasa.gov/Aura/OMI/omno2_v003.shtml ) to public and...

  18. OMI/Aura Cloud Pressure and Fraction (O2-O2 Absorption) Daily L2 Global 0.25 deg Lat/Lon Grid V003

    Data.gov (United States)

    National Aeronautics and Space Administration — The reprocessed OMI/Aura Level-2G cloud data product OMCLDO2G, is now available (http://disc.gsfc.nasa.gov/Aura/OMI/omcldo2g_v003.shtml) from the NASA Goddard Earth...

  19. OMI/Aura Ozone (O3) Total Column Daily L2 Global 0.25 deg Lat/Lon Grid V003

    Data.gov (United States)

    National Aeronautics and Space Administration — The OMI/Aura Level-2G Total Column Ozone Data Product OMTO3G (Version 003) is made available ( http://disc.gsfc.nasa.gov/Aura/OMI/omto3g_v003.shtml ) from the NASA...

  20. The Aura of the Letter : Cornelis Crul's ABC Poem in BL Sloane MS 1174 and sixteenth-century views on form and content

    NARCIS (Netherlands)

    Moser, P.H.; Mareel, S.; Buskirk, J.

    2016-01-01

    This essay focuses on the aura of the letter. It discusses eight different incarnations of one sixteenth-century alphabet poem in manuscript and print, comparing the presentation of the initials at the beginning of each stanza to clarify the relationship between aura and bibliographic code. How is

  1. OMI/Aura Ozone (O3) DOAS Total Column Daily L2 Global 0.25 deg Lat/Lon Grid V003

    Data.gov (United States)

    National Aeronautics and Space Administration — The OMI/Aura Level-2G Total Column Ozone Data Product OMDOAO3G (Version 003) is now available ( http://disc.gsfc.nasa.gov/Aura/OMI/omdoao3g_v003.shtml ) from the...

  2. OMI/Aura Sulphur Dioxide (SO2) Total Column Daily L2 Global 0.125 deg Lat/Lon Grid V003

    Data.gov (United States)

    National Aeronautics and Space Administration — The OMI/Aura Level-2G SO2 Data Product OMSO2G (Version 003) is now available http://disc.gsfc.nasa.gov/Aura/OMI/omso2g_v003.shtml ) from the NASA Goddard Earth...

  3. OMI/Aura Cloud Pressure and Fraction (O2-O2 Absorption) Zoomed 1-Orbit L2 Swath 13x12km V003

    Data.gov (United States)

    National Aeronautics and Space Administration — The reprocessed OMI/Aura Level-2 zoomed cloud data product OMCLDO2Z at 13x12 km resolution is now available ( http://disc.gsfc.nasa.gov/Aura/OMI/omcldo2z_v003.shtml...

  4. OMI/Aura Level 1B VIS Global Geolocated Earth Shine Radiances 1-orbit L2 Swath 13x24 km V003

    Data.gov (United States)

    National Aeronautics and Space Administration — The Level-1B (L1B) Radiance Product OML1BRVG (Version-3) from the Aura-OMI is now available (http://disc.gsfc.nasa.gov/Aura/OMI/oml1brvg_v003.shtml) to public from...

  5. OMI/Aura Level 1B UV Global Geolocated Earthshine Radiances 1-orbit L2 Swath 13x24 km V003

    Data.gov (United States)

    National Aeronautics and Space Administration — The Level-1B (L1B) Radiance Product OML1BRUG (Version-3) from the Aura-OMI is now available to public (http://disc.gsfc.nasa.gov/Aura/OMI/oml1brug_v003.shtml) from...

  6. OMI/Aura Level 1B UV Zoom-in Geolocated Earthshine Radiances 1-orbit L2 Swath 13x12 km V003

    Data.gov (United States)

    National Aeronautics and Space Administration — The Level-1B (L1B) Radiance Product OML1BRUZ (Version-3) from the Aura-OMI is now available (http://disc.gsfc.nasa.gov/Aura/OMI/oml1bruz_v003.shtml) to public from...

  7. Assessment of changes following en-masse retraction with mini-implants anchorage compared to two-step retraction with conventional anchorage in patients with class II division 1 malocclusion: a randomized controlled trial.

    Science.gov (United States)

    Al-Sibaie, Salma; Hajeer, Mohammad Y

    2014-06-01

    No randomized controlled trial has tried to compare treatment outcomes between the sliding en-masse retraction of upper anterior teeth supported by mini-implants and the two-step sliding retraction technique employing conventional anchorage devices. To evaluate skeletal, dental, and soft tissue changes following anterior teeth retraction. Parallel-groups randomized controlled trial on patients with class II division 1 malocclusion treated at the University of Al-Baath Dental School in Hamah, Syria between July 2011 and May 2013. One hundred and thirty-three patients with an upper dentoalveolar protrusion were evaluated and 80 patients fulfilled the inclusion criteria. Randomization was performed using computer-generated tables; allocation was concealed using sequentially numbered opaque and sealed envelopes. Fifty-six participants were analysed (mean age 22.34 ± 4.56 years). They were randomly distributed into two groups with 28 patients in each group (1:1 allocation ratio). Following first premolar extraction, space closure was accomplished using either the en-masse technique with mini-implants or the two-step technique with transpalatal arches (TPAs). The antero-posterior displacements of upper incisal edges and upper first molars were measured on lateral cephalograms at three assessment times. Assessor blinding was employed. A bodily retraction (-4.42 mm; P upper anterior teeth was achieved in the mini-implants group, whereas upper anterior teeth retraction was achieved by controlled palatal tipping in the TPA group. When retracting anterior teeth in patients with moderate to severe protrusion, the en-masse retraction based on mini-implants anchorage gave superior results compared to the two-step retraction based on conventional anchorage in terms of speed, dental changes, anchorage loss, and aesthetic outcomes.

  8. Anatomical alterations of the visual motion processing network in migraine with and without aura.

    Directory of Open Access Journals (Sweden)

    Cristina Granziera

    2006-10-01

    Full Text Available Patients suffering from migraine with aura (MWA and migraine without aura (MWoA show abnormalities in visual motion perception during and between attacks. Whether this represents the consequences of structural changes in motion-processing networks in migraineurs is unknown. Moreover, the diagnosis of migraine relies on patient's history, and finding differences in the brain of migraineurs might help to contribute to basic research aimed at better understanding the pathophysiology of migraine.To investigate a common potential anatomical basis for these disturbances, we used high-resolution cortical thickness measurement and diffusion tensor imaging (DTI to examine the motion-processing network in 24 migraine patients (12 with MWA and 12 MWoA and 15 age-matched healthy controls (HCs. We found increased cortical thickness of motion-processing visual areas MT+ and V3A in migraineurs compared to HCs. Cortical thickness increases were accompanied by abnormalities of the subjacent white matter. In addition, DTI revealed that migraineurs have alterations in superior colliculus and the lateral geniculate nucleus, which are also involved in visual processing.A structural abnormality in the network of motion-processing areas could account for, or be the result of, the cortical hyperexcitability observed in migraineurs. The finding in patients with both MWA and MWoA of thickness abnormalities in area V3A, previously described as a source in spreading changes involved in visual aura, raises the question as to whether a "silent" cortical spreading depression develops as well in MWoA. In addition, these experimental data may provide clinicians and researchers with a noninvasively acquirable migraine biomarker.

  9. Occipital transcranial magnetic stimulation discriminates transient neurological symptoms of vascular origin from migraine aura without headache.

    Science.gov (United States)

    Naeije, Gilles; Fogang, Yannick; Ligot, Noémie; Mavroudakis, Nicolas

    2017-09-01

    The diagnosis of transient neurological attacks (TNA) relies on medical history. Transient ischemic attack is often considered until proven otherwise, because of lack of objective paraclinical tools that can help discriminate TIA from differential diagnoses such as migraine aura. This may lead to needless and potentially harmful stroke secondary prevention in many cases. This study aimed at determining the yield of occipital transcranial magnetic stimulation (oTMS) in discriminating TNA of vascular origin from migraine aura without headache (MAWH). Ten patients with acute TNA of vascular origin and ten patients with migraine aura without headache (MAWH), without prior history of migrainous headache, were prospectively included. TNA of vascular origin were considered for individuals presenting unilateral focal symptoms with full resolution within 24hours and positive diffusion weighted imaging (DWI+). For individuals with MAWH, diagnostic criteria were either ICHD-III beta or Fischer criteria for a first episode of MAWH. All participants underwent one session of oTMS. Induction and threshold of phosphene induction were recorded. In TNA of vascular origin, MRI disclosed cortical lesions in nine and one sub-cortical lesion. Phosphenes were induced in 9/10 subjects with MAWH with a mean threshold of 66% of the maximal intensity, whereas oTMS induced phosphenes in only one subject with TNA of vascular origin at a threshold of 85%. In this pilot study, oTMS was found to be an effective tool to discriminate between MAWH and transient neurological symptoms of vascular origin. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

  10. Erratum: Retraction Note: Six-body bound system calculations in the case of effective α-core structure

    Science.gov (United States)

    The Publishers

    2017-10-01

    The paper has been retracted by the Editorial Board after an investigation on the possibility that part of the published results were obtained in collaboration with scientists not included in the author list.

  11. Retraction: Graphene-SnO2 nanocomposites decorated with quantum tunneling junctions: preparation strategies, microstructures and formation mechanism.

    Science.gov (United States)

    Simpson, Anna

    2017-09-20

    Retraction of 'Graphene-SnO2 nanocomposites decorated with quantum tunneling junctions: preparation strategies, microstructures and formation mechanism' by Qingxiu Wang et al., Phys. Chem. Chem. Phys., 2014, 16, 19351-19357.

  12. Open Access Works are as Reliable as Other Publishing Models at Retracting Flawed Articles from the Biomedical Literature

    Directory of Open Access Journals (Sweden)

    Elizabeth Margaret Stovold

    2014-09-01

    Full Text Available A Review of: Peterson, G.M. (2013. Characteristics of retracted open access biomedical literature: a bibliographic analysis. Journal of the American Society for Information Science and Technology. 64(12, 2428-2436. doi: 10.1002/asi.22944 Objective – To investigate whether the rate of retracted articles and citation rates post-retraction in the biomedical literature are comparable across open access, free-to-access, or pay-to-access journals. Design – Citation analysis. Setting – Biomedical literature. Subjects – 160 retracted papers published between 1st January 2001 and 31st December 2010. Methods – For the retracted papers, 100 records were retrieved from the PubMed database and 100 records from the PubMed Central (PMC open access subset. Records were selected at random, based on the PubMed identifier. Each article was assigned a number based on its accessibility using the specific criteria. Articles published in the PMC open access subset were assigned a 2; articles retrieved from PubMed that were freely accessible, but did not meet the criteria for open access were assigned a 1; and articles retrieved through PubMed which were pay-to-access were assigned a 0. This allowed articles to be grouped and compared by accessibility. Citation information was collected primarily from the Science Citation Index. Articles for which no citation information was available, and those with a lifetime citation of 0 (or 1 where the citation came from the retraction statement were excluded, leaving 160 articles for analysis. Information on the impact factor of the journals was retrieved and the analysis was performed twice; first with the entire set, and second after excluding articles published in journals with an impact factor of 10 or above (14% of the total. The average number of citations per month was used to compare citation rates, and the percentage change in citation rate pre- and post-retraction was calculated. Information was also collected

  13. Visual Field Losses in Patients with Migraine without Aura and Tension-Type Headache.

    Science.gov (United States)

    Yener, Arif Ü; Korucu, Osman

    2017-04-01

    The aim of the study was to compare the visual fields during pain attacks in the patients with migraine without aura and tension-type headache using automated perimetry. In this study 25 patients with migraine and 25 patients with tension-type headache were evaluated.The optic disc, macula and retina were assessed and patients with normal values were enrolled into the study. Intraocular pressure of all patients were measured. Furthermore, visual field test was applied to both groups using Humphrey field analyzer (Carl-Zeiss Meditec, model-745 i, Dublin, CA, USA). Both mean deviation and pattern standart deviation values of these two goups were not statistically significant.

  14. Cryptocoryne aura (Araceae), a new species from West Kalimantan, Indonesia

    DEFF Research Database (Denmark)

    Wongso, Suwidji; Ipor, Isa B.; Tawan, Cheksum S.

    2016-01-01

    A new species, Cryptocoryne aura Wongso & Ipor, from West Kalimantan, Indonesia, is described and illustrated. It differs from other Cryptocoryne species primarily by having a transparent, ciliate membrane along the leaf margin and a short spathe with a yellow, forward-twisted limb. It has a chro...... a chromosome number of 2n = 26, which has not hitherto been recorded within the genus. The morphology of the germinating seed is unique within the genus, the embryo emerging c. ⅓ from the distal end of the seed with 3(or 4) plumulary processes (prophylls)....

  15. Recurrent Epileptic Auras As a Presenting Symptom of Alzheimer’s Disease

    Directory of Open Access Journals (Sweden)

    Rani A. Sarkis

    2017-07-01

    Full Text Available Seizures are a common co-morbidity during the course of Alzheimer’s disease (AD and in a subset of patients may be one of the presenting symptoms. In this case series, we highlight three patients with recurrent medically refractory epileptic auras whose work up ultimately lead to the diagnosis of AD. All three patients underwent prolonged EEG, serial neuropsychological testing, FDG-PET, cerebrospinal fluid (CSF AD biomarkers, and MRI. CSF biomarkers were particularly helpful in two cases. These cases highlight the importance of having a high index of suspicion for AD in new onset “idiopathic” epilepsy in the elderly.

  16. Aura y La señorita Christina: un diálogo posible

    Directory of Open Access Journals (Sweden)

    Mihaela Comsa

    2015-01-01

    Full Text Available Estudio intertextual de Aura , de Carlos Fuentes y La señorita Christina , de Mircea Eliade. Ambos textos se revelan como portadores de la capacidad de la literatura para condicionar la irrupción en nuestro mundo de otros espacios, tiempos y seres cuyas existencias no se sujetan, afortunadamente, a la prueba de la realidad fáctica, porque al ser pobladores de ‘frases imaginarias’, y por lo tanto, de ‘realidades imaginarias’, imponen su identidad autorreferencial.

  17. [Migraine with aura and patent foramen ovale. A different clinical entity].

    Science.gov (United States)

    Ramírez-Moreno, J M; Casado-Naranjo, I; Gómez, M; Portilla, Jc; Caballero, M; Serrano, A; Ojalvo, M J; Falcón, A; Tena-Mora, D; Calle, M

    2008-10-01

    This work has aimed to evaluate the prevalence of patent foramen ovale in subjects with migraine with aura by transcranial contrast doppler and to describe the clinical and risk profile of these patients. We performed a transcranial contrast doppler in 94 consecutive out-patients with migraine with aura (MWA) in a neurology outpatient clinic. They were divided into two groups according to the presence of patent foramen ovale: MWA_RLsh (with right-to-left shunt) and MWA_RLNsh (without right-to-left shunt). Differences between the groups were analyzed according to endpoints of age, gender, clinical severity, aura type and attacks frequency, comorbility, cardiovascular risk factors (CVRFs), neuroimaging findings, severity of shunt and treatment. n=94; MWA_RLsh: 47 (54%). MWA_RLNsh: 40 (46%). Age: 33.13; standard desviation (SD): 10.8 vs 33.496; SD: 11.2; p=0.728. Female: 66 vs 72.5%; p=0.511. Visual aura: 73.9% vs 78.9%; p=0.921. There were no significant differences in regards to the risk factors studied or to the comorbid diseases that are associated to migraine. The patients with patent foramen ovale have an odds ratio (OR) of ischemic stroke: 1.189 (95% confidence interval [CI]: 0.226 to 6.248; p=0.840), OR for subclinical brain lesions in cranial magnetic resonance imaging (MRI): 0.589 (95% CI: 0.193 to 1.799; p=0.35) and OR for combined previous ischemic stroke and subclinical brain lesions: 0.745 (95% CI: 0.261 to 2.129; p=0.58). Migraine attack frequency >1 per month: 27.9 vs 36.4; p=0.464. Need for prophylaxis therapy: 44.7 vs 57.7%; p=0.284. Both groups are similar regarding their clinical profile. We did not find a greater prevalence of stroke or silent brain lesions in the group with positive shunt..

  18. Simultaneous torquing, aligning and retraction spring: A three-dimensional approach for blocked out canines

    Directory of Open Access Journals (Sweden)

    Abhay Kumar Jain

    2016-01-01

    Full Text Available Orthodontic management of a buccally blocked-out canine requires a substantial amount of bodily movement, which is difficult to perform because of its long and bulbous root. Even when orthodontic forces are applied in a desired direction, large hyalinized areas are created which impede the root movement. Palatal root torque is needed for the canine to increase the buccal bone thickness, decrease the risk of bone dehiscence and gingival recession. Closing loops generate a distal force along with an extrusive component which retracts the canine into the extraction space but lacks control on the torque of the canine. To overcome this limitation, this simultaneous torquing, aligning, and retraction spring was designed. It can be easily fabricated, activated at chairside for either simultaneous or sequential controlled three-dimensional tooth movements.

  19. Training in Brain Retraction Using a Self-Made Three-Dimensional Model.

    Science.gov (United States)

    Mashiko, Toshihiro; Konno, Takehiko; Kaneko, Naoki; Watanabe, Eiju

    2015-08-01

    A hollow brain model was created using soft urethane. A tube passing through the hollow was attached for use as a water inlet and manometer. Water sufficient in quantity to realize the intended initial pressure was infused through the tube. The brain model was retracted with a brain spatula and the surgical corridor was opened. By measuring local force with a sensor set on the brain spatula, the model could be used for training in brain retraction. At the same time, the water column of the manometer was measured and the relationship with the force of the brain spatula was investigated. A positive correlation between the water column and local force was confirmed. This indicated that it was possible to use this model without a force sensor for the same training using water column measurements. Copyright © 2015 Elsevier Inc. All rights reserved.

  20. Brain-derived neurotrophic factor prevents dendritic retraction of adult mouse retinal ganglion cells.

    Science.gov (United States)

    Binley, Kate E; Ng, Wai S; Barde, Yves-Alain; Song, Bing; Morgan, James E

    2016-08-01

    We used cultured adult mouse retinae as a model system to follow and quantify the retraction of dendrites using diolistic labelling of retinal ganglion cells (RGCs) following explantation. Cell death was monitored in parallel by nuclear staining as 'labelling' with RGC and apoptotic markers was inconsistent and exceedingly difficult to quantify reliably. Nuclear staining allowed us to delineate a lengthy time window during which dendrite retraction can be monitored in the absence of RGC death. The addition of brain-derived neurotrophic factor (BDNF) produced a marked reduction in dendritic degeneration, even when application was delayed for 3 days after retinal explantation. These results suggest that the delayed addition of trophic factors may be functionally beneficial before the loss of cell bodies in the course of conditions such as glaucoma. © 2016 The Authors. European Journal of Neuroscience published by Federation of European Neuroscience Societies and John Wiley & Sons Ltd.