WorldWideScience

Sample records for atrs world conference

  1. The Conference Proceedings of the 2003 Air Transport Research Society (ATRS) World Conference, Volume 5

    Science.gov (United States)

    Bowen, Brent (Editor); Gudmundsson, Sveinn (Editor); Oum, Tae (Editor)

    2003-01-01

    The UNO Aviation Institute Monograph Series began in 1994 as a key component of the education outreach and information transfer missions of the Aviation Institute and the NASA Nebraska Space Grant & EPSCoR Programs. The series is an outlet for aviation materials to be indexed and disseminated through an efficient medium. Publications are welcome in all aspects of aviation. Publication formats may include, but are not limited to, conference proceedings, bibliographies, research reports, manuals, technical reports, and other documents that should be archived and indexed for future reference by the aviation and world wide communities. The Conference proceedings of the 2003 Air Transport Research Society (ATRS) world conference, volume 5 is presented. The topics include: 1) The Temporal Configuration of Airline Networks in Europe; 2) Determination and Applications of Environmental Costs at Different Sized Airports-Aircraft Noise and Engine Emissions; 3) Cost Effective Measures to Reduce CO2 Emissions in the Air Freight Sector; 4) An Assessment of the Sustainability of Air Transport System: Quantification of Indicators; 5) Regulation, Competition and Network Evolution in Aviation; 6) Regulation in the Air: Price and Frequency Cap; 7) Industry Consolidation and Future Airline Network Structures in Europe; 8) Application of Core Theory to the U.S. Airline Industry; 9) Air Freight Transshipment Route Choice Analysis; 10) A Fuzzy Approach of the Competition on Air Transport Market; and 11) Developing Passenger Demand Models for International Aviation from/to Egypt: A Case Study of Cairo Airport and Egyptair.

  2. The Conference Proceedings of the 2001 Air Transport Research Society (ATRS) of the WCTR Society. Volume 1

    Science.gov (United States)

    Lee, Yeong-Heok (Editor); Bowen, Brent D. (Editor); Tarry, Scott E. (Editor)

    2001-01-01

    The ATRS held its Annual conference at Jeju Island, Korea in July 2001. The conference was a success with nearly 140 participants including 70 presenters. This report contains presentations from Volume 1 on the following: Airline and Travel Agent Relationships in Asia;Benchmarking Aviation Safety in the Commercial Airline Industry;Impact of Frequent Flyer Program on the Demand for Air Travel; Application of Genetic Algorithm on Airline Schedule;The Effects of Dual Carrier Designation and Partial Liberalization: The Case of Canada;Defense of Air Carriers and Air Agencies in FAA Enforcement proceedin gs - Damage Control Before the Case Arises; Cost Incentives for Airline Mergers? - An examination on the cost impact of U.S. airline mergers and acquisitions;Airport Regulation, Airline Competition and Canada's Airport System; Airline Competition: The Case of Israel's Domestic Doupoly; Non-Financial Indicators of Airline Distress: A Conceptual Approach;and Airport Privatization: An Empirical Analysis of Financial and Operational Efficiency.

  3. What Is the World Administrative Radio Conference?

    Science.gov (United States)

    Howkins, John

    1979-01-01

    Describes the issues and interests to be discussed at the World Administrative Radio Conference in September, 1979. Includes definitions of principles for the use of the frequency spectrum, rights and duties of users, reallocation of frequency bands, and the need for principles to guide international cooperation. (JMF)

  4. World Conference on Acoustic Emission 2013

    CERN Document Server

    Wu, Zhanwen; Zhang, Junjiao

    2015-01-01

    This volume collects the papers from the 2013 World Conference on Acoustic Emission in Shanghai. The latest research and applications of Acoustic Emission (AE) are explored, with particular emphasis on detecting and processing of AE signals, development of AE instrument and testing standards, AE of materials, engineering structures and systems, including the processing of collected data and analytical techniques as well as experimental case studies.

  5. World Conference on Acoustic Emission 2015

    CERN Document Server

    Wu, Zhanwen; Zhang, Junjiao

    2017-01-01

    This volume collects the papers from the World Conference on Acoustic Emission 2015 (WCAE-2015) in Hawaii. The latest research and applications of Acoustic Emission (AE) are explored, with particular emphasis on detecting and processing of AE signals, development of AE instrument and testing standards, AE of materials, engineering structures and systems, including the processing of collected data and analytical techniques as well as experimental case studies.

  6. The Conference Proceedings of the 2001 Air Transport Research Society (ATRS) of the WCTR Society. Volume 2

    Science.gov (United States)

    Lee, Yeong-Heok (Editor); Bowen, Brent D. (Editor); Tarry, Scott E. (Editor)

    2001-01-01

    The ATRS held its 5th Annual conference at the City University of Hong Kong Campus in July 2001. The conference was a success with nearly 140 participants including 70 presenters. Titles that comprise Volume 2 include: Intelligent Airport Gate Assignment System; A Study on the Effects of the Personality Compatibility to the Job Performance; ITS/CVO Application for Air cargo Transportation in Korea; An Airport as a Logistics and Economic Hub: The Case of Incheon International Airport; The Impact Of Aviation Safety over the Consumer's Behavior; The Integration of China and Taiwan Air Networks for Direct Air Cargo Services; Quality perception and carrier choice in Civil Aviation; Future Trends in Business Travel Decision Making; Cooperation Among German Airports in Europe; Inbound and Outbound Air Passenger Traffic Forecasting between the United States and Selected Asian countries; An Evaluation of Alternative Facilities for Airport Redevelopment using Fuzzy Linguistic Approach; Economic Analysis of Airline Alliances; The Aviation Cooperation between the two Koreas Preparing for the Reunification of the Peninsula; and A Study on the Air Transport Cooperation in Northeast Asia between China, Japan and Korea.

  7. [4th World Conference on Women].

    Science.gov (United States)

    1995-06-01

    The World Platform of Action is a document prepared by the secretary of the UN Commission on the Status of Women (CSW) that acknowledges commitments made by the subscribing governments. In the final preparatory meeting for the Fourth International Conference on Women in Beijing, official delegations of the world's governments discussed the draft of the Platform of Action. Throughout the Platform, there is evidence of a retreat from concepts internationally recognized at other conferences. The Vatican, in alliance with countries like Honduras, Argentina, and Guatemala, and with fundamentalist religious groups, is largely responsible for the obstruction. The draft indicates which topics have failed to gain consensus and require discussion at the full Conference. The Platform is defined as an agenda for seeking empowerment of women, an objective necessitating removal of obstacles to active participation by women in all spheres of public life. The Platform defines the critical areas for action as the persistent increase in poverty among women, unequal access to education and training, unequal access to health care, violence against women and girls, effects of persecution and armed conflicts, unequal access to productive processes, and unequal power and influence in decision making at all levels. Insufficient mechanisms for promoting women, protection of the human rights of women, women and communication, and women and the environment are other priority topics. Problems are discussed in each of these areas, and objectives and concrete actions are proposed. The work describes the types of institutional changes that will be needed if the objectives are to be achieved; defines sex, gender, and other relevant terms; and analyses some of the strategic objectives in greater detail. The final section contains recommendations for women's groups and other lobbyists in Colombia to present to the government.

  8. 4th World Conference on Soft Computing

    CERN Document Server

    Abbasov, Ali; Yager, Ronald; Shahbazova, Shahnaz; Reformat, Marek

    2016-01-01

    This book reports on advanced theories and cutting-edge applications in the field of soft computing. The individual chapters, written by leading researchers, are based on contributions presented during the 4th World Conference on Soft Computing, held May 25-27, 2014, in Berkeley. The book covers a wealth of key topics in soft computing, focusing on both fundamental aspects and applications. The former include fuzzy mathematics, type-2 fuzzy sets, evolutionary-based optimization, aggregation and neural networks, while the latter include soft computing in data analysis, image processing, decision-making, classification, series prediction, economics, control, and modeling. By providing readers with a timely, authoritative view on the field, and by discussing thought-provoking developments and challenges, the book will foster new research directions in the diverse areas of soft computing. .

  9. Proceedings of the 4. World TRIGA Users Conference

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2008-10-29

    This document gathers 30 presentations given at the 2008 Conference of the World TRIGA reactor Users. Most presentations are in the form of slides only, and few ones have an additional summary or are presented as an article only. All aspects of TRIGA-type reactors are approached, from upgrading to decommissioning, from radiotherapy to isotope production, from research program management to training, etc.

  10. Visions for a sustainable world: A conference on science, technology and social responsibility. Conference report

    Energy Technology Data Exchange (ETDEWEB)

    1992-12-31

    This report summarizes the organization, activities, and outcomes of Student Pugwash USA`s 1992 International Conference, Visions for a Sustainable World: A Conference on Science, Technology and Social Responsibility. The conference was held June 14--20, 1992 at Emory University, and brought together 94 students and over 65 experts from industry, academe, and government. The conference addressed issues ranging from global environmental cooperation to the social impacts of the Human Genome Project to minority concerns in the sciences. It provided a valuable forum for talented students and professionals to engage in critical dialogue on many interdisciplinary issues at the juncture of science, technology and society. The conference challenged students -- the world`s future scientists, engineers, and political leaders -- to think broadly about global problems and to devise policy options that are viable and innovative. The success of the conference in stimulating interest, understanding, and enthusiasm about interdisciplinary global issues is clearly evident from both the participants` feedback and their continued involvement in Student Pugwash USA programs. Six working groups met each morning. The working group themes included: environmental challenges for developing countries; energy options: their social and environmental impact; health care in developing countries; changing dynamics of peace and global security; educating for the socially responsible use of technology; ethics and the use of genetic information. The conference was specifically designed to include mechanisms for ensuring its long-term impact. Participants were encouraged to focus on their individual role in helping resolve global issues. This was achieved through each participant`s development of a Personal Plan of Action, a plan which mapped out activities the student could undertake after the conference to continue the dialogue and work towards the resolution of global and local problems.

  11. 6th World Conference for Graduate Research in Tourism, Hospitality and Leisure 2nd Interdisciplinary Tourism Research Conference

    National Research Council Canada - National Science Library

    Fabia Trentin; Carlos Alberto Lidizia Soares; Bianca Tempone

    2012-01-01

      In the period of 24 to 29 April, were realized the events 6th World Conference for Graduate Research in Tourism, Hospitality and Leisure 2nd Interdisciplinary Tourism Research Conference, organized...

  12. 2014 World Conference on Information Systems and Technologies

    CERN Document Server

    Correia, Ana; Tan, Felix; Stroetmann, Karl

    2014-01-01

    This book contains a selection of articles from The 2014 World Conference on Information Systems and Technologies (WorldCIST'14), held between the 15th and 18th of April in Funchal, Madeira, Portugal, a global forum for researchers and practitioners to present and discuss recent results and innovations, current trends, professional experiences and challenges of modern Information Systems and Technologies research, technological development and applications. The main topics covered are: Information and Knowledge Management; Organizational Models and Information Systems; Intelligent and Decision Support Systems; Software Systems, Architectures, Applications and Tools; Computer Networks, Mobility and Pervasive Systems; Radar Technologies; Human-Computer Interaction; Health Informatics; and Information Technologies in Education.

  13. The Conference Proceedings of the 2001 Air Transport Research Society (ATRS) of the WCTR Society. Volume 3

    Science.gov (United States)

    Lee, Yeong-Heok (Editor); Bowen, Brent D. (Editor); Tarry, Scott E. (Editor)

    2001-01-01

    The papers presented at this conference include: 1) The Global Airline Company: Agent of Market Power or Competition? 2) Airport Pavement Management; 3) Reservation System Providers and the Impact of Codeshare Arrangements on Screen Display; 4) Strategic Classification of Current Airline Alliances and Examination of Critical Factors Involving the Formations - an Explorative Perspective; 5) Airport Privatization Policy and Performance Measurement in Korea; 6) Pilot and Air Traffic Controller Relationships: The Role of Interdependence and Relative Influence; 7) Liberalization of Air Cargo Services: Background and an Economic Analysis; 8) The Implication of Hub and Spoke Network on the Airline Alliance Strategy.

  14. 2016 World Conference on Information Systems and Technologies

    CERN Document Server

    Correia, Ana; Adeli, Hojjat; Reis, Luis; Teixeira, Marcelo

    2016-01-01

    This book contains a selection of articles from The 2016 World Conference on Information Systems and Technologies (WorldCIST'16), held between the 22nd and 24th of March at Recife, Pernambuco, Brazil. WorldCIST is a global forum for researchers and practitioners to present and discuss recent results and innovations, current trends, professional experiences and challenges of modern Information Systems and Technologies research, together with their technological development and applications. The main topics covered are: Information and Knowledge Management; Organizational Models and Information Systems; Software and Systems Modeling; Software Systems, Architectures, Applications and Tools; Multimedia Systems and Applications; Computer Networks, Mobility and Pervasive Systems; Intelligent and Decision Support Systems; Big Data Analytics and Applications; Human-Computer Interaction; Health Informatics; Information Technologies in Education; Information Technologies in Radiocommunications.

  15. 2017 World Conference on Information Systems and Technologies

    CERN Document Server

    Correia, Ana; Adeli, Hojjat; Reis, Luís; Costanzo, Sandra

    2017-01-01

    This book presents a selection of papers from the 2017 World Conference on Information Systems and Technologies (WorldCIST'17), held between the 11st and 13th of April 2017 at Porto Santo Island, Madeira, Portugal. WorldCIST is a global forum for researchers and practitioners to present and discuss recent results and innovations, current trends, professional experiences and challenges involved in modern Information Systems and Technologies research, together with technological developments and applications. The main topics covered are: Information and Knowledge Management; Organizational Models and Information Systems; Software and Systems Modeling; Software Systems, Architectures, Applications and Tools; Multimedia Systems and Applications; Computer Networks, Mobility and Pervasive Systems; Intelligent and Decision Support Systems; Big Data Analytics and Applications; Human–Computer Interaction; Ethics, Computers & Security; Health Informatics; Information Technologies in Education; and Information Tec...

  16. 2015 World Conference on Information Systems and Technologies

    CERN Document Server

    Correia, Ana; Costanzo, Sandor; Reis, Luis

    2015-01-01

    This book contains a selection of articles from The 2015 World Conference on Information Systems and Technologies (WorldCIST'15), held between the 1st and 3rd of April in Funchal, Madeira, Portugal, a global forum for researchers and practitioners to present and discuss recent results and innovations, current trends, professional experiences and challenges of modern Information Systems and Technologies research, technological development and applications. The main topics covered are: Information and Knowledge Management; Organizational Models and Information Systems; Intelligent and Decision Support Systems; Big Data Analytics and Applications; Software Systems, Architectures, Applications and Tools; Multimedia Systems and Applications; Computer Networks, Mobility and Pervasive Systems; Human-Computer Interaction; Health Informatics; Information Technologies in Education; Information Technologies in Radiocommunications.

  17. World population: the risks and the prejudices. World Conference on Population and Development.

    Science.gov (United States)

    Goutier, H

    1994-01-01

    The UN Conference on Population and Development in Cairo during September 1994 aimed to find ways of limiting population explosion over the next 20 years (until 2015). Present world population is 5.6 billion and may double in 50 years, which would seriously compromise resources. In this article, abortion is viewed as the most controversial conference topic, which had to be carefully defined as a public health problem rather than a means of birth control. Other issues which generated considerable conflict of opinion included immigration quotas in developed countries and reservations about the "rights" of immigrants to reunite with families. Agreement was reached about the "fair principle" of reuniting families. The nongovernmental organization agenda was unsuccessful in promoting the issue of women's vulnerability to political and economic causes of migration and awareness of women's lack of access to independent refugee status or political asylum for sexual oppression. Every chapter in the UN Conference document had a reference to women. Chapter Eleven's topic on access to education for both boys and girls was diluted from "equal" access to "fair" access due to Muslim objections based on sacred writings. Taboo subjects included women's control over their bodies and premarital sex, human rights, and respect for cultures. The conference never affirmed the free right of women to make decisions about their bodies. Participants would have preferred greater attention to development issues such as the rapid decline in fertility in countries such as Colombia, Zimbabwe, Thailand, and China. The link between economic growth and population control was viewed by the conference as hypothetical. A well-known French demographer stated that the "major squanderers" of world resources are countries with low birth rates. The overpopulation fear is defined as the fear of having to share or restrict even surpluses. The most prominent statement at Cairo was made by Mrs. Bhutto, who said

  18. "To change the world." Cairo conference reaches consensus on plan to stabilize world growth by 2015.

    Science.gov (United States)

    1994-12-01

    After 6 days of debate and 200 speakers during September 5-13, 1994, participants from 180 countries at the Cairo International Conference on Population and Development (ICPD) agreed on a strategy for curbing global population growth over the next 20 years. The objective was sustained economic growth and sustainable development. In his opening remarks, UN Secretary-General Boutros Boutros-Ghali said that the objective was to balance humanity and the environment with the means to sustain life, and that the efficacy of the world economic order depended to some extent on the ICPD. Participants were urged to use rigor, tolerance, and conscience in conference deliberations. Men and women should have the right and the means to choose their families' futures. The preamble stated that the ICPD would probably be the last opportunity in the twentieth century to address globally the issues relating to population and development. UN Population Fund Executive Director Nafis Sadik remarked that the ICPD had the potential to change the world. Egyptian President Mohamed Hosni Mubarak was elected president of the ICPD. Mubarak stated that solutions to population problems must go beyond demographic accounting and incorporate change in social, economic, and cultural conditions. Norway's Prime Minister Gro Harlem Brundtland stated that development in many countries never reached many women. She called it a hypocritical morality that allowed women to suffer and die from unwanted pregnancies, illegal abortions, and miserable living conditions. US Vice President Albert Gore called for comprehensive and holistic solutions. The essential features of social change would involve democracy, economic reform, low rates of inflation, low levels of corruption, sound environmental management, free and open markets, and access to developed country markets. Pakistan's Prime Minister Benazir urged the empowerment of women. Many expressed the concern about unsustainable consumption in industrialized

  19. 2013 World Conference on Information Systems and Technologies (WorldCIST’13)

    CERN Document Server

    Correia, Ana; Wilson, Tom; Stroetmann, Karl; Advances in Information Systems and Technologies

    2013-01-01

    This book contains a selection of articles from The 2013 World Conference on Information Systems and Technologies (WorldCIST'13), a global forum for researchers and practitioners to present and discuss the most recent innovations, trends, results, experiences and concerns in the several perspectives of Information Systems and Technologies. The main topics covered are: Information and Knowledge Management; Organizational Models and Information Systems; Intelligent and Decision Support Systems; Software Systems, Architectures, Applications and Tools; Computer Networks, Mobility and Pervasive Systems; Radar Technologies; and Human-Computer Interaction.

  20. Purchasing & supply management for a sustainable world: Introduction to the IPSERA 2013 conference special issue

    DEFF Research Database (Denmark)

    Johnsen, T. E.; Giannakis, M.; Miemczyk, J.

    2014-01-01

    Special issue of best papers of the 22nd annual IPSERA conference 2013: Purchasing & Supply Management for a Sustainable World......Special issue of best papers of the 22nd annual IPSERA conference 2013: Purchasing & Supply Management for a Sustainable World...

  1. IDRC at the World Conference of Science Journalists 2017 | IDRC ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    2017-12-13

    class journalists with a scientific beat, many with a keen interest in the Centre's mandate and core body of work. IDRC's presence at the WCSJ2017 also offered outstanding networking opportunities with conference organizers, ...

  2. ATR promotes cilia signalling: links to developmental impacts.

    Science.gov (United States)

    Stiff, Tom; Casar Tena, Teresa; O'Driscoll, Mark; Jeggo, Penny A; Philipp, Melanie

    2016-04-15

    Mutations in ATR(ataxia telangiectasia and RAD3-related) cause Seckel syndrome (ATR-SS), a microcephalic primordial dwarfism disorder. Hitherto, the clinical manifestation of ATR deficiency has been attributed to its canonical role in DNA damage response signalling following replication fork stalling/collapse. Here, we show that ATR regulates cilia-dependent signalling in a manner that can be uncoupled from its function during replication. ATR-depleted or patient-derived ATR-SS cells form cilia of slightly reduced length but are dramatically impaired in cilia-dependent signalling functions, including growth factor and Sonic hedgehog signalling. To better understand the developmental impact of ATR loss of function, we also used zebrafish as a model. Zebrafish embryos depleted of Atr resembled ATR-SS morphology, showed a modest but statistically significant reduction in cilia length and other morphological features indicative of cilia dysfunction. Additionally, they displayed defects in left-right asymmetry including ambiguous expression of southpaw, incorrectly looped hearts and randomized localization of internal organs including the pancreas, features typically conferred by cilia dysfunction. Our findings reveal a novel role for ATR in cilia signalling distinct from its canonical function during replication and strengthen emerging links between cilia function and development. © The Author 2016. Published by Oxford University Press.

  3. Tobacco Industry Strategies to Undermine the 8th World Conference on Tobacco or Health

    National Research Council Canada - National Science Library

    M. E. Muggli; R. D. Hurt

    2003-01-01

    Objective: To demonstrate that Philip Morris and British American Tobacco Company attempted to initiate a wide ranging campaign to undermine the success of the 8th World Conference on Tobacco or Health held...

  4. 17th Online World Conference on Soft Computing in Industrial Applications

    CERN Document Server

    Krömer, Pavel; Köppen, Mario; Schaefer, Gerald

    2014-01-01

    This volume of Advances in Intelligent Systems and Computing contains accepted papers presented at WSC17, the 17th Online World Conference on Soft Computing in Industrial Applications, held from December 2012 to January 2013 on the Internet. WSC17 continues a successful series of scientific events started over a decade ago by the World Federation of Soft Computing. It brought together researchers from over the world interested in the ever advancing state of the art in the field. Continuous technological improvements make this online forum a viable gathering format for a world class conference. The aim of WSC17 was to disseminate excellent research results and contribute to building a global network of scientists interested in both theoretical foundations and practical applications of soft computing.   The 2012 edition of the Online World Conference on Soft Computing in Industrial Applications consisted of general track and special session on Continuous Features Discretization for Anomaly Intrusion Detectors...

  5. 6th World Conference on 21st Century Mathematics

    CERN Document Server

    Choudary, ADR; Waldschmidt, Michel

    2015-01-01

    Numerous well-presented and important papers from the conference are gathered in the proceedings for the purpose of pointing directions for useful future research in diverse areas of mathematics including algebraic geometry, analysis, commutative algebra, complex analysis, discrete mathematics, dynamical systems, number theory and topology. Several papers on computational and applied mathematics such as wavelet analysis, quantum mechanics, piecewise linear modeling, cosmological models of super symmetry, fluid dynamics, interpolation theory, optimization, ergodic theory and games theory are also presented.

  6. 3. world TRIGA users conference. Papers and abstracts

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2006-07-01

    The Conference is focused on TRIGA reactors operation and applications. The main topics are: use of the reactor as a research tool; inspection of spent fuel elements; integrity of fuel rods cladding checks; evaluation of corrosion of aluminum-base fuel cladding materials; Pitting behavior of Aluminum alloys; Monte Carlo simulation of TRIGA: reactivity worth, burnup, flux and power; irradiation facilities; thermal hydraulics analyses etc.

  7. Hawaii PV: 4. world conference on photovoltaic energy conversion

    Energy Technology Data Exchange (ETDEWEB)

    Pearsall, Nicola; Forbes, Ian [Northumbria Univ., Northumbria Photovoltaics Applications Centre (NPAC) (United Kingdom)

    2006-07-15

    A discussion of the technologies and topics on show at the conference under the headings: novel materials and devices; CIGS, II and IV and related thin film cells and technologies; concentrator cells and systems, III-V materials and devices; crystalline silicon solar cells and technologies; amorphous, nanocrystalline and thin film silicon; PV cells and systems for space; PV modules and system components; terrestrial PV systems; PV programmes, policies and economics; silicon concentrators and tracking; and markets (UK.) (author)

  8. Atlantic Test Range (ATR)

    Data.gov (United States)

    Federal Laboratory Consortium — ATR controls fully-instrumented and integrated test ranges that provide full-service support for cradle-to-grave testing. Airspace and surface target areas are used...

  9. UNESCO World Conference on Education for Sustainable Development: Learning Today for a Sustainable Future

    Science.gov (United States)

    Journal of Education for Sustainable Development, 2012

    2012-01-01

    The UNESCO World Conference on Education for Sustainable Development (ESD) will be co-organised in 2014 by UNESCO and the Government of Japan on the occasion of the end of the UN Decade of Education for Sustainable Development. It has the following objectives: (1) Celebrating a decade of action; (2) Reorienting education to build a better future…

  10. ATR Power Supplies

    Energy Technology Data Exchange (ETDEWEB)

    Bruno, Don [Brookhaven National Lab. (BNL), Upton, NY (United States)

    1996-09-10

    The ATR (AGS to RHIC Transfer Line) is fed beam from two synchrotron rings. The first synchrotron ring is the Booster which receives protons from a 200MeV Linac and can achieve a proton energy of 1.5GeV. The Booster can also receive heavy ions from a 15.5MV Tandem Van de Graaff. The Booster is about 1/8 of a mile in circumference. The Booser then Feeds the AGS (Alternating Gradient Synchrotron) wich can achieve a proton energy of 29.5 Gev. The AGS is about 1/2 of a mile in circumference. The AGS then kicks the beam out to the ATR line which will eventually feed RHIC (Relativistic Heavy Ion Collider) beam starting with the sextant test in December of 1996. The ATR line is about 1/2 mile long. The ATR line is made up of the upgraded U-line, new W, X and Y lines (see Figure 1). The test in November and December of 1995 transported beam from the AGS to the end of the W-line into a beam stop. During the normal operation of RHIC there will be a switching magnet at the end of the W-line which will bend beam into the X-Line and then into the Y-line so that the two beams in RHIC will be rotating in opposite directions.

  11. World Conference on Local Initiatives for Sustainable Cities, November 2-4 1995, Yokohama, Japan. Conference report.

    Science.gov (United States)

    Mathee, A

    1996-03-01

    This article describes the objectives, preamble, declarations, specific issues, and follow-up of the World Conference on Local Initiatives for Sustainable Cities. The conference was held in the City of Yokohama, Kanagawa Prefecture, Japan, during November 2-4, 1995. Participants included representatives from 192 local authorities from 62 countries. Other participants included national/international governments and organizations, as well as nongovernmental organizations. The conference aimed to describe sustainable cities, to clarify problems faced by cities, and to develop local networks of cooperation. The Federal Minister of Regional Planning, Building, and Urban Development in Germany, presented the keynote address on "Toward Sustainable Cities." The Rector of the UN University spoke about the links between urbanization and sustainability in developing countries. Special sessions were devoted to industrial pollution, consumption patterns, the scale and nature of cities, energy, transportation, Local Agenda 21, and decision-making. Participants adopted the Kanagawa Declaration. The Declaration recognizes the role of local government in assuming responsibility for social welfare, environmental protection, and the threat to the global environment and human society from rapid population growth. Local authorities need to solve urban environmental problems. Sustainable cities are those that implement sustainable development. Local governments need to provide environmental information and education, form partnerships, seek international cooperation, and seek a strategy for securing sustainability on a global scale through research studies.

  12. Thoughts on the World Conference on Women. A Chinese woman writes.

    Science.gov (United States)

    Chuan, R

    1995-01-01

    Increasing social consciousness about human rights issues in China has, in turn, stimulated Chinese women's awareness of their individual rights. The Chinese government, however, has maintained tight control over the dissemination of feminist ideas and restricted media coverage of the Fourth World Conference on Women, held in Beijing in 1995. To discredit feminism, Chinese officials link it with sexual liberation, single motherhood, and lesbianism. Nonetheless, there is a new awareness that government statistics on the high rates of female employment conceal the reality that Chinese women are concentrated in low-paying, low-status occupations. In contrast to official propaganda, a United Nations Development Report ranked China 23rd in the world for women's participation in politics and the economy. In the course of preparing for the World Conference, a few nonofficial, grass-roots Chinese women's organizations were able to present their ideas.

  13. Population policy at a crossroads. Will world conference signal new directions for U.S.?

    Science.gov (United States)

    Mccarty, L; Sherman, D

    1994-06-01

    In September 1994 in Cairo, at the third population conference hosted by the United Nations, world leaders will be asked to approve a plan that could stabilize the world population at about 8 billion people by the middle of the next century. Participants will consider interrelated issues: population growth, access to family planning, women's empowerment, sustainable development, poverty, consumption, and the environment. This campaign for a more equitable world is likely to continue after Cairo, with the UN-sponsored social summit in Copenhagen and a women's conference in Beijing slated for next year. The Cairo International Conference on Population and Development will require a new approach to sustainability by balancing environmental protection, economic development, and present and future human needs. The United States has only 5% of the world's population, but it uses 25% of the world's commercial energy, produces more garbage and waste than any other country, and generates 21% of all carbon dioxide emissions, which contribute to global warming. Demands for energy, water and food already cannot be met as natural resources are being exhausted at an alarming rate. The fight over water rights to the Colorado River exemplifies the shrinking natural resource base. In contrast to the Reagan-Bush administration, the Clinton administration restored funding to international family planning agencies and endorsed sustainable development. The US birth rate is back at a 2-decade high, while 60% of pregnancies are unintended. US adolescent pregnancy is the highest among industrialized countries, leading to a cycle of poverty and soaring public costs. Government funding for new contraceptive research has been stagnant because of the pressure of right-wing groups, although finally RU-486 became available for clinical trials. The Cairo conference is likely to recognize the US as the leader in global political issues, however, domestic population and consumption issues have

  14. 1st Complex Systems Digital Campus World E-Conference 2015

    CERN Document Server

    Bourgine, Paul; Collet, Pierre

    2017-01-01

    This book contains the proceedings as well as invited papers for the first annual conference of the UNESCO Unitwin Complex System Digital Campus (CSDC), which is an international initiative gathering 120 Universities on four continents, and structured in ten E-Departments. First Complex Systems Digital Campus World E-Conference 2015 features chapters from the latest research results on theoretical questions of complex systems and their experimental domains. The content contained bridges the gap between the individual and the collective within complex systems science and new integrative sciences on topics such as: genes to organisms to ecosystems, atoms to materials to products, and digital media to the Internet. The conference breaks new ground through a dedicated video-conferencing system – a concept at the heart of the international UNESCO UniTwin, embracing scientists from low-income and distant countries. This book promotes an integrated system of research, education, and training. It also aims at contr...

  15. PUREX new substation ATR

    Energy Technology Data Exchange (ETDEWEB)

    Nelson, D.E.

    1997-05-12

    This document is the acceptance test report (ATR) for the New PUREX Main and Minisubstations. It covers the factory and vendor acceptance and commissioning test reports. Reports are presented for the Main 5 kV substation building, the building fire system, switchgear, and vacuum breaker; the minisubstation control building and switch gear; commissioning test; electrical system and loads inspection; electrical utilities transformer and cable; and relay setting changes based on operational experience.

  16. Polar Gateways Arctic Circle Sunrise 2008 Conference at the Top of the World

    Science.gov (United States)

    Cooper, J. F.; Kauristie, K.; Weatherwax, A. T.; Sheehan, G. W.; Smith, R. W.; Cline, T. D.; Lewis, E. M.; Haines-Stiles, G.

    2008-12-01

    The Polar Gateways conference was hosted during January 23-29, 2008, the first week of polar sunrise at Barrow, Alaska, at the new Barrow Arctic Research Center of the Barrow Arctic Science Consortium (BASC). The dawn week of polar day, the highly variable low temperatures, and the ice-covered shore tundra and adjacent sea ice conditions provided an appropriate locale for a conference dedicated in the spirit of the International Polar and Heliophysical Years 2007-2009 to the educational exploration of polar and icy world science of Earth and the solar system. The many scientific, educational, and cultural interactions with the local community of four thousand residents, sixty percent native Inupiat Eskimo, further provided an unforgettable experience of what life might be someday be like on other remote polar and icy worlds to be explored and eventually inhabited. Over one hundred active participants, more than half participating remotely, contributed science presentations and educational activities during this unique circumpolar and very "green" conference. Most remote contributions came via videoconference from the Swedish Institute of Space Physics (IRF) at Kiruna, Sweden, the EISCAT Svalbard Radar Facility at Spitzbergen, Norway, the University of Alaska at Fairbanks, NASA Goddard Space Flight Center and the Jet Propulsion Laboratory, the University of California at Berkeley, and the University of Arizona. A few contributors participated via teleconference, including one from the Polar Geophysical Institute at Apatity in Russia. These active contributions spanned up to thirteen time zones (Alaska to Russia) at various times during the conference. Primary videoconferencing support between Barrow and other sites was ably provided by the University of Alaska at Fairbanks, and local operators at each remote site collectively made this conference possible. Science presentations spanned the solar system from the polar Sun and heliospheric environment to Earth, Moon

  17. Polar Gateways Arctic Circle Sunrise 2008 Conference at the Top of the World

    Science.gov (United States)

    Cooper, John F.; Kauristie, Kirsti; Weatherwax, Allan T.; Sandahl, Ingrid; Ostgaard, Nikolai; Sheehan, Glenn W.; Smith, Roger W.; Lewis, Elaine M.; Cline, Troy D.; Haines-Stiles, Geoff

    2008-01-01

    The Polar Gateways conference was hosted during January 23-29, 2008, the first week of polar sunrise at Barrow, Alaska, at the new Barrow Arctic Research Center of the Barrow Arctic Science consortium (BASC). The dawn week of polar day, the highly variable low temperatures, and the ice-covered shore tundra and adjacent sea ice conditions provided an appropriate locale for a conference dedicated in the spirit of the International Polar and Heliophysical Years 2007-2009 to the educational exploration of polar and icy world science of Earth and the solar system. The many scientific, educational, and cultural interactions with the local community of four thousand residents, sixty percent native Inupiat Eskimo, further provided an unforgettable experience of what life might be someday be like on other remote polar and icy worlds to be explored and eventually inhabited. Over one hundred active participants, more than half participating remotely, contributed science presentations and educational activities during this unique circumpolar and very "green" conference. Most remote contributions came via videoconference from the Swedish Institute of Space Physics (IRF) at Kisuna, Sweden, the EISCAT Svalbard Radar Facility at Spitzbergen, Norway, the University of Alaska at Fairbanks, NASA Goddard Space Flight Center and the Jet Propulsion Laboratory, the University of California at Berkeley, and the University of Arizona. A few contributors participated via teleconference, including one from the Polar Geophysical Institute at Apatity in Russia. These active contributions spanned up to thirteen time zones (Alaska to Russia) at various tirnes during the conference. Primary videoconferencing support between Barrow and other sites was ably provided by the University of Alaska at Fairbanks, and local operators at each remote site collectively made this conference possible. Science presentations spanned the solar system from the polar Sun and heliospheric environment to Earth, Moon

  18. Archimedes in the 21st Century : World Conference at the Courant Institute of Mathematical Sciences

    CERN Document Server

    2017-01-01

    This book is a collection of papers presented at the “Archimedes in the 21st Century” world conference, held at the Courant Institute of Mathematical Sciences in 2013. This conference focused on the enduring and continuing influence of Archimedes in our modern world, celebrating his centuries of influence on mathematics, science, and engineering.  Archimedes planted the seeds for a myriad of seminal ideas that would grow over the ages. Each chapter surveys the growth of one or more of these seeds, and the fruit that they continue to bear to this day. The conference speakers contributing to this book are actively involved in STEM fields whose origins trace back to Archimedes, many of whom have conducted and published research that extends Archimedes’ work into the 21st century. The speakers are not historians, so while historical context is provided, this book is uniquely focused on the works themselves as opposed to their history.   The breadth and depth of Archimedes’ influence will inspire, deligh...

  19. MODSIM World 2007 Conference and Expo: Select Papers and Presentations from the Education and Training Track

    Science.gov (United States)

    Pinelli, Thomas E. (Editor); Sullivan, Shannon (Editor); Sanchez, Alicia (Editor)

    2008-01-01

    This NASA Conference Publication features select papers and PowerPoint presentations from the Education and Training Track of MODSIM World 2007 Conference and Expo. Invited speakers and panelists of national and international renown, representing academia, industry and government, discussed how modeling and simulation (M&S) technology can be used to accelerate learning in the K-16 classroom, especially when using M&S technology as a tool for integrating science, technology, engineering and mathematics (STEM) classes. The presenters also addressed the application ofM&S technology to learning and training outside of the classroom. Specific sub-topics of the presentations included: learning theory; curriculum development; professional development; tools/user applications; implementation/infrastructure/issues; and workforce development. There was a session devoted to student M&S competitions in Virginia too, as well as a poster session.

  20. Impact of the 1985 space World Administrative Radio Conference on frequency/orbit planning and use

    Science.gov (United States)

    Miller, E. F.

    1986-01-01

    The 1985 World Administrative Radio Conference (WARC-ORB-85) was held to determine which space radio services should be planned and which planning methods should be used. The second session of this Conference (WARC-ORB-88) will meet to develop the required plans. This paper presents the results of WARC-ORB-85, assesses the impact of those decisions, and identifies the intersessional work to be conducted by administrations and the CCIR (consultative Committee on International Radio). The major decisions of WARC-ORB-85 were: (1) the restriction of additional planning to the fixed satellite service at identified frequencies; and (2) the selection of a planning method consisting of two parts: (a) an allotment plan, and (b) improved procedures. The paper also discusses WARC-ORB-85 decisions relative to the Region 2 broadcast satellite service plans at 12 GHz, feederlink planning for Regions 1 and 3 broadcast satellites at 12 GHz, and sound broadcast satellite service.

  1. ICT, Innovation and Knowledge Challenges as seen by a World Conference of Experts

    Directory of Open Access Journals (Sweden)

    Jose Francisco Aguilar Pereira

    2015-01-01

    Full Text Available The World Conference on Computers in Agriculture (WCCA, held in San Jose Costa Rica in 2014, provided a forum where professionals from different disciplines exchanged research finding and experience on the use of ICT in a wide variety of contexts. This special issue is a collection of manuscripts by experts in agriculture and food related disciplines presenting the results of their research and experience on uses of ICT, which although not comprehensive in their scope, partially address the issues discussed in the editorial.

  2. Combining Immersive Virtual Worlds and Virtual Learning Environments into an Integrated System for Hosting and Supporting Virtual Conferences

    Science.gov (United States)

    Polychronis, Nikolaos; Patrikakis, Charalampos; Voulodimos, Athanasios

    In this paper, a proposal for hosting and supporting virtual conferences based on the use of state of the art web technologies and computer mediated education software is presented. The proposed system consists of a virtual conference venue hosted in Second Life platform, targeted at hosting synchronous conference sessions, and of a web space created with the use of the e-learning platform Moodle, targeted at serving the needs of asynchronous communication, as well as user and content management. The use of Sloodle (the next generation of Moodle software incorporating virtual world supporting capabilities), which up to now has been used only in traditional education, enables the combination of the virtual conference venue and the conference supporting site into an integrated system that allows for the conduction of successful and cost-effective virtual conferences.

  3. Camp Creates a World of Magic: The Trail to Innovative Thinking Begins at the ACA National Conference.

    Science.gov (United States)

    Coleman, Marla

    2001-01-01

    The American Camping Association 2001 National Conference at Walt Disney World draws parallels between the administration of camp programs and practices at Disney World. Seminars led by Disney managers focus on recruitment of college students, development of a corporate culture and philosophy, emphasis on environment, and quality service that…

  4. ATR Performance Estimation Seed Program

    Science.gov (United States)

    2015-09-28

    19b. TELEPHONE NUMBER (Include area code) 09/28/2015 Research Performance Report July 2014 - June 2015 ATR Performance Estimation Seed Program Cook...Report: ATR Performance Estimation Seed Program Daniel A. Cook Georgia Tech Research Institute Sensors and Electromagnetic Applications Laboratory...term seed program to expand the Navy’s efforts in performance prediction for MCM. The team included individuals from ARL/PSU, APL-UW, GTRI, and NSWC

  5. Fourth World Conference on Women, Beijing, China. What was accomplished for the League?

    Science.gov (United States)

    Laird, G

    1995-01-01

    The CCL hosted a workshop on natural family planning (NFP) at the Non-Government Organization (NGO) Forum for the Fourth World Conference on Women. It focused on the sympto-thermal method (STM) and discussed violence against women, NFP as women's empowerment, how NFP encourages men to become responsible for their fertility, and teaching and role-modeling marital fidelity to our children. Participants in the workshop came from the Philippines, Russia, China, Israel, Africa, Muslim countries, and the US. The workshop facilitator explained that pharmaceutical companies, birth control providers (e.g., Planned Parenthood), and abortion clinics promote contraception and promiscuity to meet their self-interests, while NFP teachers make no money. Due to logistical difficulties, another CCL workshop, NFP and the Reluctant Husband, began two hours later than scheduled. Even though many people had come to hear what the workshop had to offer, many left. A few women and a Chinese obstetrician/gynecologist did return, however. The CCL representative spent most of her time talking with the physician about STM (e.g., its mechanics), building one's marriage, credibility to our children, and the parents' role in teaching children sexual abstinence. She and a CCL couple teaching English in China helped the Vatican and other countries promote positive language in the document of the women's conference. They regularly met with the pro-family coalition to discuss ways to lobby for a more acceptable document and to share ideas with a representative of the Pope's delegation. The final document is anti-family, anti-chastity, and anti-God. More than 40 countries submitted formal reservations on the final document on the last day of the conference.

  6. Identification of a Novel System for Boron Transport: Atr1 Is a Main Boron Exporter in Yeast▿ †

    Science.gov (United States)

    Kaya, Alaattin; Karakaya, Huseyin C.; Fomenko, Dmitri E.; Gladyshev, Vadim N.; Koc, Ahmet

    2009-01-01

    Boron is a micronutrient in plants and animals, but its specific roles in cellular processes are not known. To understand boron transport and functions, we screened a yeast genomic DNA library for genes that confer resistance to the element in Saccharomyces cerevisiae. Thirty boron-resistant transformants were isolated, and they all contained the ATR1 (YML116w) gene. Atr1 is a multidrug resistance transport protein belonging to the major facilitator superfamily. C-terminal green fluorescent protein-tagged Atr1 localized to the cell membrane and vacuole, and ATR1 gene expression was upregulated by boron and several stress conditions. We found that atr1Δ mutants were highly sensitive to boron treatment, whereas cells overexpressing ATR1 were boron resistant. In addition, atr1Δ cells accumulated boron, whereas ATR1-overexpressing cells had low intracellular levels of the element. Furthermore, atr1Δ cells showed stronger boron-dependent phenotypes than mutants deficient in genes previously reported to be implicated in boron metabolism. ATR1 is widely distributed in bacteria, archaea, and lower eukaryotes. Our data suggest that Atr1 functions as a boron efflux pump and is required for boron tolerance. PMID:19414602

  7. 18{sup th} world hydrogen energy conference 2010 (WHEC 2010). Proceedings. Speeches and plenary talks

    Energy Technology Data Exchange (ETDEWEB)

    Stolten, Detlef; Emonts, Bernd (eds.)

    2012-07-03

    A comprehensive and renowned conference offers the opportunity to extend the scope beyond mere technical issues. It allows for having strategic presentations and discussing aspects of market introduction, industrial and Governmental target setting as well as approaches to and actions for implementation. The 18th World Hydrogen Conference 2010, WHEC2010, succeeded in exploiting this opportunity and satisfied the expectations. Strong political support in Germany and in the State of North Rhine Westphalia in particular made it possible to have high profile decision makers at the conference presenting their strategies first hand. Hence, a full day was dedicated to plenary speeches and overview talks. The WHEC2010 came handy at a time when fuel cells are developed to suit the requirements for vehicles, except for cost and durability. At a time when the competition with batteries and whether or how a hydrogen infrastructure can be established and afforded were hot topics in the public debate, which needed answers on a well informed basis. Considering fuel cells and hydrogen at a time at one conference and supplementing it with the current knowledge on batteries and hybridization clarity on the future role of these technologies was gained. Very likely fuel cells and batteries will coexist in a future of electrified vehicular transport. Their different technical characteristics will open the doors to different market segments. Implementing hydrogen infrastructure, being a requirement for fuel cells in transport, is considered doable and affordable. This book presents the speeches and overview papers from the plenary session of the WHEC2010 on May 17, 2010. Six further books of this issue contain the papers of the oral and poster presentations, except for the introductory talks of the sessions. The latter are published separately by Wiley in a book named Hydrogen and Fuel Cells. In total the 18th WHEC is documented on over 3800 pages in a structured way in order to reach

  8. IFLA General Conference, 1987. Conference Opening and Plenary. "Library and Information Services in a Changing World." Papers.

    Science.gov (United States)

    International Federation of Library Associations, The Hague (Netherlands).

    The three papers in this collection were presented at the opening of the conference and the plenary session. The first is the "Presidential Address: Brighton, 1987 = Eroffnungsansprache zur IFLA Generalkonferenz Brighton 1987" (Hans-Peter Geh). These remarks by the President of the International Federation of Library Associations (IFLA) address…

  9. Creating Cultures of Peace: Pedagogical Thought and Practice. Selected Papers from the 10th Triennial World Conference (September 10-15, 2001, Madrid, Spain)

    Science.gov (United States)

    Benton, Jean E., Ed.; Swami, Piyush, Ed.

    2007-01-01

    The 10th Triennial World Conference of the World Council for Curriculum and Instruction (WCCI) was held September 10-15, 2001 in Madrid, Spain. The theme of the conference was "Cultures of Peace." Thirty-four papers and presentations are divided into nine sections. Part I, Tributes to the Founders of WCCI, includes: (1) Tribute to Alice…

  10. ED-MEDIA/ED-TELECOM 98 World Conference on Educational Multimedia and Hypermedia & World Conference on Educational Telecommunications. Proceedings (10th, Freiburg, Germany, June 20-25, 1998).

    Science.gov (United States)

    Ottmann, Thomas, Ed.; Tomek, Ivan, Ed.

    This collection presents papers pertaining to the wide area of educational multimedia/hypermedia and telecommunications. The conference serves as a forum for the dissemination of information on the research, development, and applications in all areas of multimedia/hypermedia and telecommunications in education across all disciplines and levels.…

  11. ATR Spent Fuel Options Study

    Energy Technology Data Exchange (ETDEWEB)

    Connolly, Michael James [Idaho National Lab. (INL), Idaho Falls, ID (United States); Bean, Thomas E. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Brower, Jeffrey O. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Luke, Dale E. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Patterson, M. W. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Robb, Alan K. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Sindelar, Robert [Idaho National Lab. (INL), Idaho Falls, ID (United States); Smith, Rebecca E. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Tonc, Vincent F. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Tripp, Julia L. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Winston, Philip L. [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2017-01-01

    The Advanced Test Reactor (ATR) is a materials and fuels test nuclear reactor that performs irradiation services for the U.S. Department of Energy (DOE) Office of Nuclear Energy (NE), Naval Reactors, the National Nuclear Security Administration (NNSA), and other research programs. ATR achieved initial criticality in 1967 and is expected to operate in support of needed missions until the year 2050 or beyond. It is anticipated that ATR will generate approximately 105 spent nuclear fuel (SNF) elements per year through the year 2050. Idaho National Laboratory (INL) currently stores 2,008 ATR SNF elements in dry storage, 976 in wet storage, and expects to have 1,000 elements in wet storage before January 2017. A capability gap exists at INL for long-term (greater than the year 2050) management, in compliance with the Idaho Settlement Agreement (ISA), of ATR SNF until a monitored retrievable geological repository is open. INL has significant wet and dry storage capabilities that are owned by the DOE Office of Environmental Management (EM) and operated and managed by Fluor Idaho, which include the Idaho Nuclear Technology and Engineering Center’s (INTEC’s) CPP-666, CPP-749, and CPP-603. In addition, INL has other capabilities owned by DOE-NE and operated and managed by Battelle Energy Alliance, LLC (BEA), which are located at the Materials and Fuel Complex (MFC). Additional storage capabilities are located on the INL Site at the Naval Reactors Facility (NRF). Current INL SNF management planning, as defined in the Fluor Idaho contract, shows INTEC dry fuel storage, which is currently used for ATR SNF, will be nearly full after transfer of an additional 1,000 ATR SNF from wet storage. DOE-NE tasked BEA with identifying and analyzing options that have the potential to fulfill this capability gap. BEA assembled a team comprised of SNF management experts from Fluor Idaho, Savannah River Site (SRS), INL/BEA, and the MITRE Corp with an objective of developing and analyzing

  12. 7th World Conference on Mass Customization, Personalization, and Co-Creation

    CERN Document Server

    Nielsen, Kjeld; Joergensen, Kaj; Taps, Stig

    2014-01-01

    The MCPC 2014 is a multi‐track conference featuring a combination of high profile keynotes with expert talks, panel discussions, paper sessions, workshops, receptions, and much more. While it is devoted to sharing and discussing the latest research in the field, the MCPC conference has a strong focus on real life applications. Since its beginning, the MCPC conference has had an equal share of participants, practitioners and academics/researchers. This makes the MCPC conference truly unique among many conferences. It strives to connect MCPC thinkers, first movers, entrepreneurs, technology developers, and researchers with people applying these strategies in practice. Twenty years ago Mass Customization was acknowledged as the ”New Frontier in Business Competition”. Ever since, industry has been applying the concept and researchers have developed the topic into a well-established research area and businesses have formed new strategies. More knowledge, methods and technologies are available now than ever b...

  13. The All-Russian Scientific Conference “The Ananyino World: Sources, Development, Interrelations, Historical Destinies”

    Directory of Open Access Journals (Sweden)

    Kuzminykh Sergey V.

    2012-06-01

    Full Text Available The report on the conference, which was held in Bolgar (the Republic of Tatarstan in November, 2012, and dedicated to the Ananyino cultural and historical community, is presented. A wide range of problems related to the final Bronze Age and the Early Iron Age in the forest-steppe zone of European Russia, the Urals and Western Siberia were considered. Special attention was paid to the intercultural relations of the time. The results of the latest research in the field, including broad historical and cultural generalizations, are presented. It was decided to publish the materials contributed, and to hold future similar conferences at 3-4- years’ intervals.

  14. Key features for ATA / ATR database design in missile systems

    Science.gov (United States)

    Özertem, Kemal Arda

    2017-05-01

    Automatic target acquisition (ATA) and automatic target recognition (ATR) are two vital tasks for missile systems, and having a robust detection and recognition algorithm is crucial for overall system performance. In order to have a robust target detection and recognition algorithm, an extensive image database is required. Automatic target recognition algorithms use the database of images in training and testing steps of algorithm. This directly affects the recognition performance, since the training accuracy is driven by the quality of the image database. In addition, the performance of an automatic target detection algorithm can be measured effectively by using an image database. There are two main ways for designing an ATA / ATR database. The first and easy way is by using a scene generator. A scene generator can model the objects by considering its material information, the atmospheric conditions, detector type and the territory. Designing image database by using a scene generator is inexpensive and it allows creating many different scenarios quickly and easily. However the major drawback of using a scene generator is its low fidelity, since the images are created virtually. The second and difficult way is designing it using real-world images. Designing image database with real-world images is a lot more costly and time consuming; however it offers high fidelity, which is critical for missile algorithms. In this paper, critical concepts in ATA / ATR database design with real-world images are discussed. Each concept is discussed in the perspective of ATA and ATR separately. For the implementation stage, some possible solutions and trade-offs for creating the database are proposed, and all proposed approaches are compared to each other with regards to their pros and cons.

  15. The 2015 Paris Climate Conference: A turning point in the world's energy history

    Science.gov (United States)

    Klimenko, V. V.; Mikushina, O. V.; Tereshin, A. G.

    2016-06-01

    It has been established that the consistent implementation of the 2015 Paris Climate Conference implies the quick retire of coal from the global energy balance and its replacement with the energy from unconventional and renewable sources. It is shown that even the full-scale implementation of the agreement will not keep global warming within 2°C.

  16. APOBEC3A and APOBEC3B Activities Render Cancer Cells Susceptible to ATR Inhibition.

    Science.gov (United States)

    Buisson, Rémi; Lawrence, Michael S; Benes, Cyril H; Zou, Lee

    2017-09-01

    The apolipoprotein B mRNA editing enzyme catalytic polypeptide-like APOBEC3A and APOBEC3B have emerged as key mutation drivers in cancer. Here, we show that APOBEC3A and APOBEC3B activities impose a unique type of replication stress by inducing abasic sites at replication forks. In contrast to cells under other types of replication stress, APOBEC3A-expressing cells were selectively sensitive to ATR inhibitors (ATRi), but not to a variety of DNA replication inhibitors and DNA-damaging drugs. In proliferating cells, APOBEC3A modestly elicited ATR but not ATM. ATR inhibition in APOBEC3A-expressing cells resulted in a surge of abasic sites at replication forks, revealing an ATR-mediated negative feedback loop during replication. The surge of abasic sites upon ATR inhibition associated with increased accumulation of single-stranded DNA, a substrate of APOBEC3A, triggering an APOBEC3A-driven feed-forward loop that ultimately drove cells into replication catastrophe. In a panel of cancer cell lines, ATRi selectively induced replication catastrophe in those harboring high APOBEC3A and/or APOBEC3B activities, showing that APOBEC3A and APOBEC3B activities conferred susceptibility to ATRi. Our results define an APOBEC-driven replication stress in cancer cells that may offer an opportunity for ATR-targeted therapy. Cancer Res; 77(17); 4567-78. ©2017 AACR. ©2017 American Association for Cancer Research.

  17. Energy and the public as viewed by the World Energy Conference. Energie und Oeffentlichkeit aus der Sicht der WEK

    Energy Technology Data Exchange (ETDEWEB)

    Wiedemann, P.M. (Kernforschungsanlage Juelich GmbH (Germany, F.R.). Programmgruppe Technik und Gesellschaft); Jungermann, H. (Technische Univ. Berlin (Germany, F.R.). Inst. fuer Psychologie)

    1989-09-01

    The committee 'Energy and the Public', set up by the World Energy Conference, at this year's meeting of the WEK presented a comparative international study on the attitude of the public towards systems of energy production, respectively energy supply. Attitudes towards a certain energy system depend on different aspects: With nuclear energy it is above all the safety aspect; for the rest, environmental-protection and economic aspects are important. But the conflict between materialistic and postmaterialistic values also influences people's energy-political convictions. What this study documents is the origin of a world-wide problem-consciousness that energy policy has to contend with if it wants to be economically, environmentally, and socially compatible. (orig./UA).

  18. Proceedings of the world heavy oil congress : 2009 business and technical conference

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2009-07-01

    This international conference provided a forum for collaborative examination of issues facing the heavy oil industry. The complete heavy oil value chain was examined in order to define short-term and long-term challenges and supply solutions. Leading experts were linked with the latest technologies for the unconventional oil industry. Participants from Venezuela, Canada, China, Brazil, France, Italy, Mexico, Netherlands, Norway, Russia, the United Kingdom and the United States presented case studies and field results, along with numerical simulation and laboratory investigations. The topics ranged from innovative oil sands processing and upgrading technologies; reservoir exploitation strategies; produced water treatment; sand control; reservoir monitoring; cementing design; geomechanics; and recovery processes such as cold heavy oil production with sand (CHOPS), chemical flooding, steam assisted gravity drainage, in-situ combustion and toe-to-heel air injection (THAI). The technical conference featured sessions on drilling and completions; fuels and upgrading; thermal recovery operations; field development; enhanced oil recovery and emerging recovery technologies; reservoir characterization; oil and water treatment; processing and transportation; production facilities; upgrading technology; and production technology. All 100 papers from the technical sessions have been catalogued separately for inclusion in this database. refs., tabs., figs.

  19. Abstracts presented at the 7th World Alliance for Risk Factor Surveillance (WARFS) Global Conference. October 16-19, 2011. Toronto, Ontario, Canada.

    Science.gov (United States)

    2012-01-01

    The 7th World Alliance for Risk Factor Surveillance (WARFS) Global Conference, hosted by the Public Health Agency of Canada, was held in Toronto, Ontario, Canada, from October 16 to 19, 2011. Previous WARFS conferences were held in USA (1999), Finland (2001), Australia (2003), Uruguay (2005) and Italy (2007, 2009). WARFS is a global working group on surveillance under the International Union for Health Promotion and Education (IUHPE) It supports the development of risk factor surveillance as a tool for evidence-based public health, acknowledging the importance of this source of information to inform, monitor and evaluate disease prevention and health promotion policies and programs. The theme of the 2011 Global Conference was the role of surveillance in the promotion of health. The Global Conference had 146 registered participants, making it the second most attended WARFS conference in its history. Over the three days, participants attended oral and poster presentations from 30 countries. The conference would not have been possible without the hard work of the International Scientific Committee and the Local Organizing Committee. To highlight the importance and the significance of this conference at an international level, Chronic Diseases and Injuries in Canada (CDIC) is pleased to publish this supplementary issue, which contains 70 abstracts presented at the 7th WARFS Global Conference. In the spirit the Global Conference, this collection of abstracts brings together surveillance material on risk factors, chronic diseases, infectious diseases and injuries from around the world. By making these abstracts widely available, CDIC hopes to further the conference objectives through a continued dialogue between those interested in linking risk factor surveillance to health promotion.

  20. White Paper Report of the 2011 RAD-AID Conference on International Radiology for Developing Countries: Integrating Multidisciplinary Strategies for Imaging Services in the Developing World

    Science.gov (United States)

    Mazal, Jonathan; Lexa, Frank; Starikovsky, Anna; Jimenez, Pablo; Jain, Sanjay; DeStigter, Kristen K.; Nathan, Robert; Krebs, Elizabeth; Noble, Vicki; Marks, William; Hirsh, Richard N.; Short, Brad; Sydnor, Ryan; Timmreck-Jackson, Emily; Lungren, Matthew P.; Maxfield, Charles; Azene, Ezana M.; Garra, Brian S.; Choi, Brian G.; Lewin, Jonathan S.; Mollura, Daniel J.

    2016-01-01

    The 2011 RAD-AID Conference on International Radiology for Developing Countries discussed data, experiences and models pertaining to radiology in the developing world, where widespread shortages of imaging services significantly reduce health care quality and increase health care disparity. This white paper from the 2011 RAD-AID Conference represents consensus advocacy of multidisciplinary strategies to improve planning, accessibility and quality of imaging services in the developing world. Conference presenters and participants discussed numerous solutions to imaging and healthcare disparities including: (1) economic development for radiology service planning, (2) public health mechanisms to address disease and prevention at the population and community levels, (3) comparative clinical models to implement various clinical and workflow strategies adapted to unique developing world community contexts, (4) education to improve training and optimize service quality, and (5) technology innovation to bring new technical capabilities to limited-resource regions. PMID:22748790

  1. Report of the 4th World Climate Research Programme International Conference on Reanalyses

    Science.gov (United States)

    Bosilovich, Michael G.; Rixen, Michel; van Oevelen, Peter; Asrar, Ghassem; Compo, Gilbert; Onogi, Kazutoshi; Simmons, Adrian; Trenberth, Kevin; Behringer, Dave; Bhuiyan, Tanvir Hossain; hide

    2012-01-01

    The 4th WCRP International Conference on Reanalyses provided an opportunity for the international community to review and discuss the observational and modelling research, as well as process studies and uncertainties associated with reanalysis of the Earth System and its components. Characterizing the uncertainty and quality of reanalyses is a task that reaches far beyond the international community of producers, and into the interdisciplinary research community, especially those using reanalysis products in their research and applications. Reanalyses have progressed greatly even in the last 5 years, and newer ideas, projects and data are coming forward. While reanalysis has typically been carried out for the individual domains of atmosphere, ocean and land, it is now moving towards coupling using Earth system models. Observations are being reprocessed and they are providing improved quality for use in reanalysis. New applications are being investigated, and the need for climate reanalyses is as strong as ever. At the heart of it all, new investigators are exploring the possibilities for reanalysis, and developing new ideas in research and applications. Given the many centres creating reanalyses products (e.g. ocean, land and cryosphere research centres as well as NWP and atmospheric centers), and the development of new ideas (e.g. families of reanalyses), the total number of reanalyses is increasing greatly, with new and innovative diagnostics and output data. The need for reanalysis data is growing steadily, and likewise, the need for open discussion and comment on the data. The 4th Conference was convened to provide a forum for constructive discussion on the objectives, strengths and weaknesses of reanalyses, indicating potential development paths for the future.

  2. Education, Nation-Building and Modernization after World War I: American Ideas for the Peace Conference

    Science.gov (United States)

    Ment, David M.

    2005-01-01

    The First World War ended with the collapse of the Austro-Hungarian, Russian, German and Ottoman Empires. In planning for the peace negotiations the allied governments considered not only the European boundaries but especially the national aspirations and future development of the peoples of the Balkans, the Caucasus, the Middle East, Africa and…

  3. 16th International Conference on Hybrid Intelligent Systems and the 8th World Congress on Nature and Biologically Inspired Computing

    CERN Document Server

    Haqiq, Abdelkrim; Alimi, Adel; Mezzour, Ghita; Rokbani, Nizar; Muda, Azah

    2017-01-01

    This book presents the latest research in hybrid intelligent systems. It includes 57 carefully selected papers from the 16th International Conference on Hybrid Intelligent Systems (HIS 2016) and the 8th World Congress on Nature and Biologically Inspired Computing (NaBIC 2016), held on November 21–23, 2016 in Marrakech, Morocco. HIS - NaBIC 2016 was jointly organized by the Machine Intelligence Research Labs (MIR Labs), USA; Hassan 1st University, Settat, Morocco and University of Sfax, Tunisia. Hybridization of intelligent systems is a promising research field in modern artificial/computational intelligence and is concerned with the development of the next generation of intelligent systems. The conference’s main aim is to inspire further exploration of the intriguing potential of hybrid intelligent systems and bio-inspired computing. As such, the book is a valuable resource for practicing engineers /scientists and researchers working in the field of computational intelligence and artificial intelligence.

  4. ATR Commissioning Software Task Force Report

    Energy Technology Data Exchange (ETDEWEB)

    D' Ottavio, Ted [Brookhaven National Lab. (BNL), Upton, NY (United States); Kewisch, Jorg [Brookhaven National Lab. (BNL), Upton, NY (United States); Saltmarsh, Chris [Brookhaven National Lab. (BNL), Upton, NY (United States); Sathe, Smita [Brookhaven National Lab. (BNL), Upton, NY (United States); Satogata, Todd [Brookhaven National Lab. (BNL), Upton, NY (United States); Shea, Don [Brookhaven National Lab. (BNL), Upton, NY (United States); Tepikian, Steve [Brookhaven National Lab. (BNL), Upton, NY (United States); Trahern, Garry [Brookhaven National Lab. (BNL), Upton, NY (United States)

    1994-12-16

    The Beam Injection Tests Software Task Force was charged with studying the software needed for the ATR tests, seen as a stepping stone or template for the larger scope of the full RHIC control system. This report outlines our avenues of exploration so far, presents the current analysis and implementation work in progress, and gives recommendations for the future on the ATR and longer time scales.

  5. Structural elucidation and functional characterization of the Hyaloperonospora arabidopsidis effector protein ATR13.

    Directory of Open Access Journals (Sweden)

    Lauriebeth Leonelli

    2011-12-01

    Full Text Available The oomycete Hyaloperonospora arabidopsidis (Hpa is the causal agent of downy mildew on the model plant Arabidopsis thaliana and has been adapted as a model system to investigate pathogen virulence strategies and plant disease resistance mechanisms. Recognition of Hpa infection occurs when plant resistance proteins (R-genes detect the presence or activity of pathogen-derived protein effectors delivered to the plant host. This study examines the Hpa effector ATR13 Emco5 and its recognition by RPP13-Nd, the cognate R-gene that triggers programmed cell death (HR in the presence of recognized ATR13 variants. Herein, we use NMR to solve the backbone structure of ATR13 Emco5, revealing both a helical domain and a disordered internal loop. Additionally, we use site-directed and random mutagenesis to identify several amino acid residues involved in the recognition response conferred by RPP13-Nd. Using our structure as a scaffold, we map these residues to one of two surface-exposed patches of residues under diversifying selection. Exploring possible roles of the disordered region within the ATR13 structure, we perform domain swapping experiments and identify a peptide sequence involved in nucleolar localization. We conclude that ATR13 is a highly dynamic protein with no clear structural homologues that contains two surface-exposed patches of polymorphism, only one of which is involved in RPP13-Nd recognition specificity.

  6. International Conference on Remote Sensing Applications for Archaeological Research and World Heritage Conservation

    Science.gov (United States)

    2002-01-01

    Contents include the following: Monitoring the Ancient Countryside: Remote Sensing and GIS at the Chora of Chersonesos (Crimea, Ukraine). Integration of Remote Sensing and GIS for Management Decision Support in the Pendjari Biosphere Reserve (Republic of Benin). Monitoring of deforestation invasion in natural reserves of northern Madagascar based on space imagery. Cartography of Kahuzi-Biega National Park. Cartography and Land Use Change of World Heritage Areas and the Benefits of Remote Sensing and GIS for Conservation. Assessing and Monitoring Vegetation in Nabq Protected Area, South Sinai, Egypt, using combine approach of Satellite Imagery and Land Surveys. Evaluation of forage resources in semi-arid savannah environments with satellite imagery: contribution to the management of a protected area (Nakuru National Park) in Kenya. SOGHA, the Surveillance of Gorilla Habitat in World Heritage sites using Space Technologies. Application of Remote Sensing to monitor the Mont-Saint-Michel Bay (France). Application of Remote Sensing & GIS for the Conservation of Natural and Cultural Heritage Sites of the Southern Province of Sri Lanka. Social and Environmental monitoring of a UNESCO Biosphere Reserve: Case Study over the Vosges du Nord and Pfalzerwald Parks using Corona and Spot Imagery. Satellite Remote Sensing as tool to Monitor Indian Reservation in the Brazilian Amazonia. Remote Sensing and GIS Technology for Monitoring UNESCO World Heritage Sites - A Pilot Project. Urban Green Spaces: Modern Heritage. Monitoring of the technical condition of the St. Sophia Cathedral and related monastic buildings in Kiev with Space Applications, geo-positioning systems and GIS tools. The Murghab delta palaeochannel Reconstruction on the Basis of Remote Sensing from Space. Acquisition, Registration and Application of IKONOS Space Imagery for the cultural World Heritage site at Mew, Turkmenistan. Remote Sensing and VR applications for the reconstruction of archaeological landscapes

  7. Proceedings of the fourth international conference and exhibition: World Congress on superconductivity. Volume 1

    Energy Technology Data Exchange (ETDEWEB)

    Krishen, K.; Burnham, C. [eds.] [National Aeronautics and Space Administration, Houston, TX (United States). Lyndon B. Johnson Space Center

    1994-12-31

    The goals of the World Congress on Superconductivity (WCS) have been to establish and foster the development and commercial application of superconductivity technology on a global scale by providing a non-adversarial, non-advocacy forum where scientists, engineers, businessmen and government personnel can freely exchange information and ideas on recent developments and directions for the future of superconductive research. Sessions were held on: accelerator technology, power and energy, persistent magnetic fields, performance characterization, physical properties, fabrication methodology, superconductive magnetic energy storage (SMES), thin films, high temperature materials, device applications, wire fabrication, and granular superconductors. Individual papers are indexed separately.

  8. White Paper Report of the 2010 RAD-AID Conference on International Radiology for Developing Countries: Identifying Sustainable Strategies for Imaging Services in the Developing World

    Science.gov (United States)

    Welling, Rodney D.; Azene, Ezana M.; Kalia, Vivek; Pongpirul, Krit; Starikovsky, Anna; Sydnor, Ryan; Lungren, Matthew P.; Johnson, Benjamin; Kimble, Cary; Wiktorek, Sarah; Drum, Tom; Short, Brad; Cooper, Justin; Khouri, Nagi F.; Mayo-Smith, William W.; Mahesh, Mahadevappa; Goldberg, Barry B.; Garra, Brian S.; DeStigter, Kristen K.; Lewin, Jonathan S.; Mollura, Daniel J.

    2015-01-01

    The 2010 RAD-AID Conference on International Radiology for Developing Countries was a multidisciplinary meeting to discuss data, experiences, and models pertaining to radiology in the developing world, where widespread shortages of imaging services reduce health care quality. The theme of this year’s conference was sustainability, with a focus on establishing and maintaining imaging services in resource-limited regions. Conference presenters and participants identified 4 important components of sustainability: (1) sustainable financing models for radiology development, (2) integration of radiology and public health, (3) sustainable clinical models and technology solutions for resource-limited regions, and (4) education and training of both developing and developed world health care personnel. PMID:21807349

  9. Following the Fourth World Conference on Women -- Let's Expand Grass-Roots Networking! Proceedings of the International Forum on Intercultural Exchange (Saitama, Japan, November 15-17, 1995).

    Science.gov (United States)

    National Women's Education Centre, Saitama (Japan).

    Based on the success of the Fourth World Conference on Women, the National Women's Education Centre of Japan planned and carried out the 1995 International Forum on Intercultural Exchange to search for an up-to-date understanding of the problems of women and ways to solve them and to develop a network of already existing groups. This Forum focused…

  10. Languages and Communication for World Business and the Professions. Proceedings of the Annual Conference (6th, Ann Arbor, Michigan, May 8-9, 1987).

    Science.gov (United States)

    Des Harnais, Gaston R., Ed.

    Topics covered in papers presented at a conference on languages and communication for world business and the professions include: (1) trends and aspects of internationalizing the business curriculum; (2) internationalized programs in business, foreign language, and cultures; (3) internationalized courses in business, foreign languages, and…

  11. Hands That Shape the World: Report on the Conditions of Immigrant Women in the U.S. Five Years after the Beijing Conference.

    Science.gov (United States)

    National Network for Immigrant and Refugee Rights, Oakland, CA.

    This report details the challenges that immigrant women in the United States have faced since the 1995 United Nations World Conference on Women in Beijing, China. It presents a compilation of research and synthesis by immigrants' rights activists and organizations. Data come from immigrant women's testimony. The following topics are featured:…

  12. "Radical" Feminists and "Bickering" Women: Backlash in U.S. Media Coverage of the United Nations Fourth World Conference on Women.

    Science.gov (United States)

    Danner, Lauren; Walsh, Susan

    1999-01-01

    Analyzes United States' newspaper coverage of the United Nations Fourth World Conference on Women for themes indicating backlash against feminism. Finds that several backlash themes, such as women in conflict and stereotypical portrayals of women, were present throughout the coverage. (CR)

  13. The 5th IUPAP International Conference on Women in Physics: Making progress in the number of women in physics around the world

    Science.gov (United States)

    Cunningham, Beth

    2015-04-01

    A short report on the 5th IUPAP International Conference on Women in Physics (ICWIP) will be presented. In particular, a summary of the structure of the 5th ICWIP that occurred in Waterloo, Canada in August 2014 will be provided and placed into context of the previous four conferences. In addition, a synopsis of the recent efforts that are happening around the world to encourage girls and women to participate in physics will be given. Several US projects have been very successful in introducing girls to science and physics (e.g., ``Expanding Your Horizons'' intervention) and encouraging undergraduate women physics majors to continue into physics careers (e.g., Conferences for Undergraduate Women in Physics). Projects from other countries, such as the Juno Project in the UK that rates physics departments on their climate for women, might be implemented by US physics professional societies as well as colleges and universities. Several projects originating from the conference will be described: the new ``HERstories: Encouraging words from women in physics'' video based on interviews with delegates of the Conference, the My STEM Story project (http://mystemstory.wlu.ca), and the proceedings of the conference. Partial support provided by NSF #PHY-1419453.

  14. Network analysis of global tobacco control collaboration: data from the World Conference on Tobacco or Health (WCTOH

    Directory of Open Access Journals (Sweden)

    Scott J. Leischow

    2017-04-01

    Full Text Available Abstract Background The World Conference on Tobacco or Health (WCTOH is held every three years to foster communication and collaboration on global tobacco control. Very little is known about the nature of interactions between WCTOH attendees and their linkages to tobacco control organizations, so knowing this information could help improve tobacco control efforts. Methods At the 2015 WCTOH, we implemented an online survey to assess barriers to global tobacco control activities, which information sources they use for tobacco control information, and with whom they interact regarding tobacco control. Results A total of 169 respondents completed the survey, with responses from all six World Health Organization (WHO regions. Respondents worked in all areas of tobacco control; the most common were research (29.2% and patient care/treatment (23.3%. The top barriers faced regarding tobacco control activities were: funding is weak (56.8%, government commitment (45.0%, tobacco industry interference (43.8%, and lack of coordination (34.3%. The network analysis identified Framework Convention Alliance (FCA and Society for Research on Nicotine and Tobacco (SRNT as the two most prominent groups that people belonged to and where they went to exchange information and best practices. Important regional and country specific groups also appear to be growing, such as the African Tobacco Control Alliance (ATCA and the Argentinian Association of Tabacology (ASAT. Discussion Mapping and better understanding the global tobacco control network is important for informing knowledge exchange and best practices, particularly as increasing attention is being focused on global tobacco control efforts in low- and middle-income countries in particular. Conclusions The present study demonstrates that even a subsample of the WCTOH shows considerable collaboration. The full WCTOH network should be mapped in order to foster greater collaboration that has the the potential to

  15. Network analysis of global tobacco control collaboration: data from the World Conference on Tobacco or Health (WCTOH).

    Science.gov (United States)

    Leischow, Scott J; Okamoto, Janet; McIntosh, Scott; Ossip, Deborah J; Lando, Harry A

    2017-04-20

    The World Conference on Tobacco or Health (WCTOH) is held every three years to foster communication and collaboration on global tobacco control. Very little is known about the nature of interactions between WCTOH attendees and their linkages to tobacco control organizations, so knowing this information could help improve tobacco control efforts. At the 2015 WCTOH, we implemented an online survey to assess barriers to global tobacco control activities, which information sources they use for tobacco control information, and with whom they interact regarding tobacco control. A total of 169 respondents completed the survey, with responses from all six World Health Organization (WHO) regions. Respondents worked in all areas of tobacco control; the most common were research (29.2%) and patient care/treatment (23.3%). The top barriers faced regarding tobacco control activities were: funding is weak (56.8%), government commitment (45.0%), tobacco industry interference (43.8%), and lack of coordination (34.3%). The network analysis identified Framework Convention Alliance (FCA) and Society for Research on Nicotine and Tobacco (SRNT) as the two most prominent groups that people belonged to and where they went to exchange information and best practices. Important regional and country specific groups also appear to be growing, such as the African Tobacco Control Alliance (ATCA) and the Argentinian Association of Tabacology (ASAT). Mapping and better understanding the global tobacco control network is important for informing knowledge exchange and best practices, particularly as increasing attention is being focused on global tobacco control efforts in low- and middle-income countries in particular. The present study demonstrates that even a subsample of the WCTOH shows considerable collaboration. The full WCTOH network should be mapped in order to foster greater collaboration that has the the potential to improve global tobacco control efforts.

  16. MIR-ATR sensor for process monitoring

    Science.gov (United States)

    Geörg, Daniel; Schalk, Robert; Methner, Frank-Jürgen; Beuermann, Thomas

    2015-06-01

    A mid-infrared attenuated total reflectance (MIR-ATR) sensor has been developed for chemical reaction monitoring. The optical setup of the compact and low-priced sensor consists of an IR emitter as light source, a zinc selenide (ZnSe) ATR prism as boundary to the process, and four thermopile detectors, each equipped with an optical bandpass filter. The practical applicability was tested during esterification of ethanol and formic acid to ethyl formate and water as a model reaction with subsequent distillation. For reference analysis, a Fourier transform mid-infrared (FT-MIR) spectrometer with diamond ATR module was applied. On-line measurements using the MIR-ATR sensor and the FT-MIR spectrometer were performed in a bypass loop. The sensor was calibrated by multiple linear regression in order to link the measured absorbance in the four optical channels to the analyte concentrations. The analytical potential of the MIR-ATR sensor was demonstrated by simultaneous real-time monitoring of all four chemical substances involved in the esterification and distillation process. The temporal courses of the sensor signals are in accordance with the concentration values achieved by the commercial FT-MIR spectrometer. The standard error of prediction for ethanol, formic acid, ethyl formate, and water were 0.38 mol L  -  1, 0.48 mol L  -  1, 0.38 mol L  -  1, and 1.12 mol L  -  1, respectively. A procedure based on MIR spectra is presented to simulate the response characteristics of the sensor if the transmission ranges of the filters are varied. Using this tool analyte specific bandpass filters for a particular chemical reaction can be identified. By exchanging the optical filters, the sensor can be adapted to a wide range of processes in the chemical, pharmaceutical, and beverage industries.

  17. Proceedings of the third USGS modeling conference, June 7-11, 2010, Broomfield, Colorado-Understanding and predicting for a changing world

    Science.gov (United States)

    Brady, Shailaja R.

    2011-01-01

    The Third USGS Modeling Conference was held June 7th-11, 2010, in Broomfield, Colorado. The conference focused on the development and application of analytical and theoretical models and data availability that support managing the Nation's resources and help protect lives and property. Participants at the conference included scientists and managers from Department of the Interior (DOI) Bureaus; national and international Federal, State, and local agencies; academic institutions; and nongovernmental organizations. The conference was organized according to DOI priorities and the strategic directions of the USGS Science Strategy; the following themes were emphasized: (1) Understanding Ecosystems and Restoring America's Treasured Landscapes; (2) Climate Change and Impact; (3) New Energy Frontier and Minerals for America; (4) A National Hazards, Risk, and Resilience Assessment Program; (5) Role of Environment and Wildlife in Human Health; (6) A Water Census of the United States; and (7) New Methods of Investigation and Discovery. The conference theme-"Understanding and Predicting for a Changing World"-focused on the following goals: advance development and application of models; provide tools that address management issues; present state-of-the-art models ranging from individual phenomena to integrated systems; and foster a working community among scientists and managers.

  18. Current Business and Economics Driven Discourse and Education: Perspectives from around the World. BCES Conference Books, Volume 15

    Science.gov (United States)

    Popov, Nikolay, Ed.; Wolhuter, Charl, Ed.; Kalin, Jana, Ed.; Hilton, Gillian, Ed.; Ogunleye, James, Ed.; Niemczyk, Ewelina, Ed.; Chigisheva, Oksana, Ed.

    2017-01-01

    This volume contains selected papers submitted to the 15th Annual International Conference of the Bulgarian Comparative Education Society (BCES), held in June 2017 in Borovets, Bulgaria, and papers submitted to the 5th International Partner Conference of the International Research Centre (IRC) "Scientific Cooperation," Rostov-on-Don,…

  19. Twenty-fifth Semiannual Report of the Commission to the Congress, January 1959. Atomic Industrial Process and Second World Conference, July - December 1958

    Energy Technology Data Exchange (ETDEWEB)

    McCone, John A.

    1959-01-31

    The document represents the twenty-fifth semiannual Atomic Energy Commission (AEC) report to Congress. The report sums up the major activities and developments in the national atomic energy program in Part Three, covering the period July - December 1958. A special Part One of this semiannual report is titled ''Industrial Atomic Progress During 1958", and a Part Two entitled "Second World Conference on Peaceful Uses of Atomic Energy".

  20. Is the world finally waking up to HIV/AIDS in prisons? A report from the XV International AIDS Conference.

    Science.gov (United States)

    2004-12-01

    Issues related to HIV/AIDS in prisons have traditionally received little attention at the International AIDS Conference, despite the fact that levels of HIV prevalence within prison populations tend to be much higher than in the general population. However, the conference in Bangkok may represent a turning point. This article highlights some of the relevant findings presented at the conference. A longer version of this article, including background information about HIV/AIDS in prisons worldwide, has been published in the September 2004 issue of Infectious Diseases in Corrections Report.

  1. Conference "Internet, Web, What's next?" on 26 June 1998 at CERN: Mark Bernstein, Vice President of CNN Interactive, describes the impact of the Web on world media and predicts what we can expect as the next developments

    CERN Multimedia

    1998-01-01

    Conference "Internet, Web, What's next?" on 26 June 1998 at CERN: Mark Bernstein, Vice President of CNN Interactive, describes the impact of the Web on world media and predicts what we can expect as the next developments

  2. Polar Gateways Arctic Circle Sunrise Conference 2008, Barrow, Alaska: IHY-IPY Outreach on Exploration of Polar and Icy Worlds in The Solar System

    Science.gov (United States)

    Cooper, John F.; Kauristie, K.; Weatherwax, A. T.; Sheehan, G. W.; Smith, R. W.; Sandahl, I.; Østgaard, N.; Chernouss, S.; Moore, M. H.; Peticolas, L. M.; Senske, D. A.; Thompson, B. J.; Tamppari, L. K.; Lewis, E. M.

    2008-09-01

    Polar, heliophysical, and planetary science topics related to the International Heliophysical and Polar Years 2007-2009 were addressed during this circumpolar video conference hosted January 23-29, 2008 at the new Barrow Arctic Research Center of the Barrow Arctic Science Consortium in Barrow, Alaska. This conference was planned as an IHY-IPY event science outreach event bringing together scientists and educational specialists for the first week of sunrise at subzero Arctic temperatures in Barrow. Science presentations spanned the solar system from the polar Sun to Earth, Moon, Mars, Jupiter, Saturn, and the Kuiper Belt. On-site participants experienced look and feel of icy worlds like Europa and Titan by being in the Barrow tundra and sea ice environment and by going "on the ice" during snowmobile expeditions to the near-shore sea ice environment and to Point Barrow, closest geographic point in the U.S. to the North Pole. Many science presentations were made remotely via video conference or teleconference from Sweden, Norway, Russia, Canada, Antarctica, and the United States, spanning up to thirteen time zones (Alaska to Russia) at various times. Extensive educational outreach activities were conducted with the local Barrow and Alaska North Slope communities and through the NASA Digital Learning Network live from the "top of the world" at Barrow. The Sun-Earth Day team from Goddard, and a videographer from the Passport to Knowledge project, carried out extensive educational interviews with many participants and native Inupiaq Eskimo residents of Barrow. Video and podcast recordings of selected interviews are available at http://sunearthday.nasa.gov/2008/multimedia/podcasts.php. Excerpts from these and other interviews will be included in a new high definition video documentary called "From the Sun to the Stars: The New Science of Heliophysics" from Passport to Knowledge that will later broadcast on NASA TV and other educational networks. Full conference

  3. Polar Gateways Arctic Circle Sunrise Conference 2008, Barrow, Alaska: IHY-IPY Outreach on Exploration of Polar and Icy Worlds in the Solar System

    Science.gov (United States)

    Cooper, John F.; Kauristie, Kirsti; Weatherwax, Allan T.; Sheehan, Glenn W.; Smith, Roger W.; Sandahl, Ingrid; Ostgaard, Nikolai; Chernouss, Sergey; Thompson, Barbara J.; Peticolas, Laura; hide

    2008-01-01

    Polar, heliophysical, and planetary science topics related to the International Heliophysical and Polar Years 2007-2009 were addressed during this circumpolar video conference hosted January 23-29, 2808 at the new Barrow Arctic Research Center of the Barrow Arctic Science Consortium in Barrow, Alaska. This conference was planned as an IHY-IPY event science outreach event bringing together scientists and educational specialists for the first week of sunrise at subzero Arctic temperatures in Barrow. Science presentations spanned the solar system from the polar Sun to Earth, Moon, Mars, Jupiter, Saturn, and the Kuiper Belt. On-site participants experienced look and feel of icy worlds like Europa and Titan by being in the Barrow tundra and sea ice environment and by going "on the ice" during snowmobile expeditions to the near-shore sea ice environment and to Point Barrow, closest geographic point in the U.S. to the North Pole. Many science presentations were made remotely via video conference or teleconference from Sweden, Norway, Russia, Canada, Antarctica, and the United States, spanning up to thirteen time zones (Alaska to Russia) at various times. Extensive educational outreach activities were conducted with the local Barrow and Alaska North Slope communities and through the NASA Digital Learning Network live from the "top of the world" at Barrow. The Sun- Earth Day team from Goddard, and a videographer from the Passport to Knowledge project, carried out extensive educational interviews with many participants and native Inupiaq Eskimo residents of Barrow. Video and podcast recordings of selected interviews are available at http://sunearthday.nasa.gov/2008/multimedidpodcasts.php. Excerpts from these and other interviews will be included in a new high definition video documentary called "From the Sun to the Stars: The New Science of Heliophysics" from Passport to Knowledge that will later broadcast on NASA TV and other educational networks. Full conference

  4. Rationally Designed PI3Kα Mutants to Mimic ATR and Their Use to Understand Binding Specificity of ATR Inhibitors.

    Science.gov (United States)

    Lu, Yipin; Knapp, Mark; Crawford, Kenneth; Warne, Robert; Elling, Robert; Yan, Kelly; Doyle, Michael; Pardee, Gwynn; Zhang, Li; Ma, Sylvia; Mamo, Mulugeta; Ornelas, Elizabeth; Pan, Yue; Bussiere, Dirksen; Jansen, Johanna; Zaror, Isabel; Lai, Albert; Barsanti, Paul; Sim, Janet

    2017-06-02

    ATR, a protein kinase in the PIKK family, plays a critical role in the cell DNA-damage response and is an attractive anticancer drug target. Several potent and selective inhibitors of ATR have been reported showing significant antitumor efficacy, with most advanced ones entering clinical trials. However, due to the absence of an experimental ATR structure, the determinants contributing to ATR inhibitors' potency and specificity are not well understood. Here we present the mutations in the ATP-binding site of PI3Kα to progressively transform the pocket to mimic that of ATR. The generated PI3Kα mutants exhibit significantly improved affinity for selective ATR inhibitors in multiple chemical classes. Furthermore, we obtained the X-ray structures of the PI3Kα mutants in complex with the ATR inhibitors. The crystal structures together with the analysis on the inhibitor affinity profile elucidate the roles of individual amino acid residues in the binding of ATR inhibitors, offering key insights for the binding mechanism and revealing the structure features important for the specificity of ATR inhibitors. The ability to obtain structural and binding data for these PI3Kα mutants, together with their ATR-like inhibitor binding profiles, makes these chimeric PI3Kα proteins valuable model systems for structure-based inhibitor design. Copyright © 2017 The Author(s). Published by Elsevier Ltd.. All rights reserved.

  5. Cytoplasmic ATR Activation Promotes Vaccinia Virus Genome Replication

    Directory of Open Access Journals (Sweden)

    Antonio Postigo

    2017-05-01

    Full Text Available In contrast to most DNA viruses, poxviruses replicate their genomes in the cytoplasm without host involvement. We find that vaccinia virus induces cytoplasmic activation of ATR early during infection, before genome uncoating, which is unexpected because ATR plays a fundamental nuclear role in maintaining host genome integrity. ATR, RPA, INTS7, and Chk1 are recruited to cytoplasmic DNA viral factories, suggesting canonical ATR pathway activation. Consistent with this, pharmacological and RNAi-mediated inhibition of canonical ATR signaling suppresses genome replication. RPA and the sliding clamp PCNA interact with the viral polymerase E9 and are required for DNA replication. Moreover, the ATR activator TOPBP1 promotes genome replication and associates with the viral replisome component H5. Our study suggests that, in contrast to long-held beliefs, vaccinia recruits conserved components of the eukaryote DNA replication and repair machinery to amplify its genome in the host cytoplasm.

  6. News Event: UK to host Science on Stage Travel: Gaining a more global perspective on physics Event: LIYSF asks students to 'cross scientific boundaries' Competition: Young Physicists' tournament is international affair Conference: Learning in a changing world of new technologies Event: Nordic physical societies meet in Lund Conference: Tenth ESERA conference to publish ebook Meeting: Rugby meeting brings teachers together Note: Remembering John L Lewis OBE

    Science.gov (United States)

    2013-03-01

    Event: UK to host Science on Stage Travel: Gaining a more global perspective on physics Event: LIYSF asks students to 'cross scientific boundaries' Competition: Young Physicists' tournament is international affair Conference: Learning in a changing world of new technologies Event: Nordic physical societies meet in Lund Conference: Tenth ESERA conference to publish ebook Meeting: Rugby meeting brings teachers together Note: Remembering John L Lewis OBE

  7. News Conference: Physics brings the community together Training: CERN trains physics teachers Education: World conference fosters physics collaborations Lecture: Physics education live at ASE Prize: Physics teacher wins first Moore medal Festival: European presidents patronize Science on Stage festival Videoconference: Videoconference brings Durban closer to the classroom

    Science.gov (United States)

    2012-03-01

    Conference: Physics brings the community together Training: CERN trains physics teachers Education: World conference fosters physics collaborations Lecture: Physics education live at ASE Prize: Physics teacher wins first Moore medal Festival: European presidents patronize Science on Stage festival Videoconference: Videoconference brings Durban closer to the classroom

  8. Scheduling EURO-k Conferences

    DEFF Research Database (Denmark)

    Stidsen, Thomas Jacob Riis; Pisinger, David; Vigo, Daniele

    2017-01-01

    EURO-k conferences are among the largest Operations Research conferences in the world, typically including more than 2000 presentations. As opposed to many other conferences, EURO-k conferences are hierarchically organized, and the conference schedule should reflect this structure to make...

  9. An add-on cap for ATR-IR spectroscopy studies

    DEFF Research Database (Denmark)

    2014-01-01

    The invention relates to a cap (300B) for an attenuated total reflectance infrared (ATR-IR) spectrometer, the ATR-IR spectrometer comprising an ATR-IR plate (200). The cap (300B) comprises an ATR- IR plate facing cap surface. When the ATR-IR plate facing cap surface is placed on the sample surface...

  10. Remarks at Opening Press Conference, IMF/World Bank Spring Meetings, Washington, D.C., April 18, 2013

    OpenAIRE

    Kim, Jim Yong

    2013-01-01

    Jim Yong Kim, President of the World Bank Group, discusses the issues to end extreme poverty in the World, promoting shared prosperity, and taking bold action on climate change. He speaks about accelerating the high growth rate in the developing world, and to translate this into poverty reduction and job creation. It must be inclusive to curb inequality. He insists that we must avert or mitigate potential shocks such as climate disas...

  11. Visión de la II Conferencia Mundial de Educación Superior (CMES, 2009 = Vision of the II World Conference on Higher Education (WCHE, 2009

    Directory of Open Access Journals (Sweden)

    Francisco Lopez Segrera

    2010-01-01

    Full Text Available El objetivo de este artículo es ofrecer algunas reflexiones sobre La Segunda Conferencia Mundial sobre Educación Superior (UNESCO, 2009, cuyo tema central fue: “Las nuevas dinámicas de la Educación Superior y la Investigación para el Cambio Social y el Desarrollo”. En la Conferencia se expresó la preocupación por la recesión mundial y suimpacto negativo en la educación superior y se formularon previsiones y recomendaciones para que dicha recesión no afecte el desarrollo de la educación superior y la investigación. El principal debate en el seno de la Conferencia giró en torno a la visión de la educaciónsuperior como “un bien público”, o como “un servicio público” o mera mercancía. En el Comunicado Final prevaleció el primer criterio.The aim of this article is to offer some reflections on The Second World Conference on Higher Education (UNESCO, 2009, whose central topic was: “The new dynamics of Higher Education and Research for the Social Change and the Development”. The Conference expressed its concern for the World recession and its negative impact on highereducation. Forecasts and recommendations were formulated in order that the above mentioned recession does not affect the development of higher education and research. The main debate in the Conference was about a key alternative: higher education as “a public good”, or as “a public service”. In the Final Communiqué the first criterion prevailed.

  12. HCLK2 is required for activity of the DNA damage response kinase ATR

    DEFF Research Database (Denmark)

    Rendtlew Danielsen, Jannie M; Larsen, Dorthe Helena; Schou, Kenneth Bødtker

    2008-01-01

    of ATR kinase activity. We show that HCLK2 forms a complex with ATR-ATRIP and the ATR activator TopBP1. We demonstrate that HCLK2-induced ATR kinase activity toward substrates requires TopBP1 and vice versa and provides evidence that HCLK2 facilitates efficient ATR-TopBP1 association. Consistent with its...... in the same pathway as TopBP1 but that the two proteins regulate different steps in ATR activation....

  13. ATR FTIR Mapping of Leather Fiber Panels

    Science.gov (United States)

    Tondi, G.; Grünewald, T.; Petutschnigg, A.; Schnabel, T.

    2015-01-01

    Leather fiber panels are very promising materials for many applications, not only for the easy availability of the constituents but also for their outstanding fi re-retardant properties. These innovative composite panels can be an excellent material for building insulation, and in recent times, the interest of industries in this composite board has considerably arisen. For this reason the discrimination of the components in the leather fiber panels is becoming fundamental in order to ensure their homogeneous properties. A method to characterize the surface of these materials is then required. An ATR FTIR mapping system for the leather fiber panels has been performed with a Perkin-Elmer microscope coupled with a Frontier FTIR spectrometer. The system has successfully allowed transforming the optical image to a chemical one. This technique can be considered as a right tool for routine controls of the surface quality, especially when the leather shavings cannot be optically distinguished.

  14. Encefalomenigocele atrésico parietal

    Directory of Open Access Journals (Sweden)

    Liliana Rivera Oliva

    2011-09-01

    Full Text Available El encefalocele es una anomalía congénita rara, en la que una porción del encéfalo protruye a través de un orificio craneal (evaginación, generalmente situado en la línea media. Clínicamente se caracteriza por una masa epicraneal, de consistencia blanda, muchas veces acompañada de trastornos psicomotores, convulsiones y trastornos de la visión. Se presenta el caso de un recién nacido con diagnóstico de encefalomeningocele atrésico parietal, intervenido quirúrgicamente y con evolución satisfactoria.

  15. ATR Prohibits Replication Catastrophe by Preventing Global Exhaustion of RPA

    DEFF Research Database (Denmark)

    Toledo Lazaro, Luis Ignacio; Altmeyer, Matthias; Rask, Maj-Britt

    2013-01-01

    origin firing generates an excess of single-stranded DNA that exhausts the nuclear pool of RPA. Partial reduction of RPA accelerated fork breakage, and forced elevation of RPA was sufficient to delay such "replication catastrophe" even in the absence of ATR activity. Conversely, unscheduled origin firing...... induced breakage of stalled forks even in cells with active ATR. Thus, ATR-mediated suppression of dormant origins shields active forks against irreversible breakage via preventing exhaustion of nuclear RPA. This study elucidates how replicating genomes avoid destabilizing DNA damage. Because cancer cells...

  16. An inaugural conference on occupational health in The Gambia: exploring the world through international occupational health programs.

    Science.gov (United States)

    Culp, Kennith; Marquez, Shannon P; Bobb, Maram; Jagne, D M B

    2005-02-01

    This conference on workplace safety was a success for both the Gambians who attended and the Americans involved in planning, implementing, and funding the conference. The Americans were delighted to bring about some understanding of worker safety to a country that has struggled with labor issues for centuries. The dialogue reflected the concern that stakeholders in both countries have for labor issues, but there is a tremendous need for ongoing partnership with industrialized countries to bring these ideas and strategies to fruition. The Gambia has received some assistance in the area of economic development, but not in improving workplace safety. A wide range of economic support activities have been initiated by the ILO in The Gambia during the past 20 years. This has included providing guidance with international labor standards, assistance to the development of labor and related services, support to employer and worker organizations, vocational training, job creation and employment policy, and small enterprise development. Many challenges lie ahead for The Gambia in improving workplace safety. Serious concerns remain related to minimum safeguards in the workplace. For example, the Labor Act specifies safety equipment that an employer must provide for employees working in designated occupations, but these are rarely offered (Culp et al., 2003). Workers are plentiful and jobs are not, so workers tend to take any employment they can without regard to working conditions. The government has not formally revoked employers who have contributed to worker deaths. Industrial inspections are conducted, although there is little consequence for violations. The cycle of poverty, younger workers, and lack of education also contribute to many worker safety issues. Farm workers cannot read instructions on pesticide containers and industrial employees cannot understand workplace hazard communications. While the Gambian constitution mandates free compulsory primary education, the

  17. LWRS ATR Irradiation Testing Readiness Status

    Energy Technology Data Exchange (ETDEWEB)

    Kristine Barrett

    2012-09-01

    The Light Water Reactor Sustainability (LWRS) Program was established by the U.S. Department of Energy Office of Nuclear Energy (DOE-NE) to develop technologies and other solutions that can improve the reliability, sustain the safety, and extend the life of the current reactors. The LWRS Program is divided into four R&D Pathways: (1) Materials Aging and Degradation; (2) Advanced Light Water Reactor Nuclear Fuels; (3) Advanced Instrumentation, Information and Control Systems; and (4) Risk-Informed Safety Margin Characterization. This report describes an irradiation testing readiness analysis in preparation of LWRS experiments for irradiation testing at the Idaho National Laboratory (INL) Advanced Test Reactor (ATR) under Pathway (2). The focus of the Advanced LWR Nuclear Fuels Pathway is to improve the scientific knowledge basis for understanding and predicting fundamental performance of advanced nuclear fuel and cladding in nuclear power plants during both nominal and off-nominal conditions. This information will be applied in the design and development of high-performance, high burn-up fuels with improved safety, cladding integrity, and improved nuclear fuel cycle economics

  18. ATR National Scientific User Facility 2009 Annual Report

    Energy Technology Data Exchange (ETDEWEB)

    Todd R. Allen; Mitchell K. Meyer; Frances Marshall; Mary Catherine Thelen; Jeff Benson

    2010-11-01

    This report describes activities of the ATR NSUF from FY-2008 through FY-2009 and includes information on partner facilities, calls for proposals, users week and education programs. The report also contains project information on university research projects that were awarded by ATR NSUF in the fiscal years 2008 & 2009. This research is university-proposed researcher under a user facility agreement. All intellectual property from these experiments belongs to the university per the user agreement.

  19. 8th World Congress on Engineering Asset Management & the 3rd International Conference on Utility Management & Safety

    CERN Document Server

    Mathew, Joseph; Wong, King; Lam, Rocky; Ko, CN; WCEAM 2013; ICUMAS; Engineering asset management : systems, professional practices and certification

    2015-01-01

    This proceedings represents state-of-the-art trends and developments in the emerging field of engineering asset management as presented at the Eight World Congress on Engineering Asset Management (WCEAM). The Proceedings of the WCEAM 2013 is an excellent reference for practitioners, researchers and students in the multidisciplinary field of asset management, covering topics such as: Asset condition monitoring and intelligent maintenance, 2.  Asset data warehousing, data mining and fusion, 3. Asset performance and level-of-service models, 4. Design and life-cycle integrity of physical assets, 5. Deterioration and preservation models for assets, 6. Education and training in asset management, 7. Engineering standards in asset management, 8. Fault diagnosis and prognostics, 9. Financial analysis methods for physical assets, 10. Human dimensions in integrated asset management, 11. Information quality management, 12. Information systems and knowledge management, 13. Intelligent sensors and devices, 14. Maintenance...

  20. Changes and Challenges: The Power of Education to Build the World to Which We Aspire. Australian College of Educators (ACE) National Conference Proceedings (Sydney, Australia, September 26-27, 2016)

    Science.gov (United States)

    Ikin, Kerrie, Ed.

    2016-01-01

    The theme of the 2016 National Conference of the Australian College of Educators (ACE), "Challenges and changes: The power of education to build the world to which we aspire," provided a unique opportunity for education professionals to carefully consider and propose papers, workshops, and poster sessions to stimulate discussion and…

  1. International Conference on Physics

    CERN Document Server

    2016-01-01

    OMICS International, (conference series) the World Class Open Access Publisher and Scientific Event Organizer is hosting “International Conference on physics” which is going to be the biggest conference dedicated to Physics. The theme “Highlighting innovations and challenges in the field of Physics” and it features a three day conference addressing the major breakthroughs, challenges and the solutions adopted. The conference will be held during June 27-29, 2016 at New Orleans, USA. Will be published in: http://physics.conferenceseries.com/

  2. FLUX SENSOR EVALUATIONS AT THE ATR CRITICAL FACILITY

    Energy Technology Data Exchange (ETDEWEB)

    Troy Unruh; Joy Rempe; David Nigg; George Imel; Jason Harris; Eric Bonebrake

    2010-11-01

    The Advanced Test Reactor (ATR) and the ATR Critical (ATRC) facilities lack real-time methods for detecting thermal neutron flux and fission reaction rates for irradiation capsules. Direct measurements of the actual power deposited into a test are now possible without resorting to complicated correction factors. In addition, it is possible to directly measure minor actinide fission reaction rates and to provide time-dependent monitoring of the fission reaction rate or fast/thermal flux during transient testing. A joint Idaho State University /Idaho National Laboratory ATR National Scientific User Facility (ATR NSUF) project was recently initiated to evaluate new real-time state-of-the-art in-pile flux detection sensors. Initially, the project is comparing the accuracy, response time, and long duration performance of French Atomic Energy Commission (CEA)-developed miniature fission chambers, specialized self-powered neutron detectors (SPNDs) by the Argentinean National Energy Commission (CNEA), specially developed commercial SPNDs, and back-to-back fission (BTB) chambers developed by Argonne National Laboratory (ANL). As discussed in this paper, specialized fixturing and software was developed by INL to facilitate these joint ISU/INL evaluations. Calculations were performed by ISU to assess the performance of and reduce uncertainties in flux detection sensors and compare data obtained from these sensors with existing integral methods employed at the ATRC. Ultimately, project results will be used to select the detector that can provide the best online regional ATRC power measurement. It is anticipated that project results may offer the potential to increase the ATRC’s current power limit and its ability to perform low-level irradiation experiments. In addition, results from this effort will provide insights about the viability of using these detectors in the ATR. Hence, this effort complements current activities to improve ATR software tools, computational

  3. “Il Dolore, il Lutto, la Gloria. Rappresentazioni Fotografiche della Grande Guerra fra Pubblico e Privato, 1914-1940” a Conference on the First World War and its Representations

    Directory of Open Access Journals (Sweden)

    Gianluigi Di Giangirolamo

    2016-11-01

    Full Text Available On the occasion of the First World War Centenary, the Department for Cultural Heritage of the University of Bologna in Ravenna together with the SISF Italian Society for the Study on photography, promoted the conference Il dolore, il lutto, la gloria. Rappresentazioni fotografiche della grande guerra fra pubblico e privato, 1914-1940 between 26-28 May, 2016. The conference was organised in collaboration with the University of Padova, the Fundation of Historical Studies Filippo Turati of Florence and the Institute of the History of Italian Risorgimento of Rome.

  4. Homeostatic regulation of meiotic DSB formation by ATM/ATR

    Energy Technology Data Exchange (ETDEWEB)

    Cooper, Tim J.; Wardell, Kayleigh; Garcia, Valerie; Neale, Matthew J., E-mail: m.neale@sussex.ac.uk

    2014-11-15

    Ataxia–telangiectasia mutated (ATM) and RAD3-related (ATR) are widely known as being central players in the mitotic DNA damage response (DDR), mounting responses to DNA double-strand breaks (DSBs) and single-stranded DNA (ssDNA) respectively. The DDR signalling cascade couples cell cycle control to damage-sensing and repair processes in order to prevent untimely cell cycle progression while damage still persists [1]. Both ATM/ATR are, however, also emerging as essential factors in the process of meiosis; a specialised cell cycle programme responsible for the formation of haploid gametes via two sequential nuclear divisions. Central to achieving accurate meiotic chromosome segregation is the introduction of numerous DSBs spread across the genome by the evolutionarily conserved enzyme, Spo11. This review seeks to explore and address how cells utilise ATM/ATR pathways to regulate Spo11-DSB formation, establish DSB homeostasis and ensure meiosis is completed unperturbed.

  5. SIGEF Conference

    CERN Document Server

    Terceño-Gómez, Antonio; Ferrer-Comalat, Joan; Merigó-Lindahl, José; Linares-Mustarós, Salvador

    2015-01-01

    This book is a collection of selected papers presented at the SIGEF conference, held at the Faculty of Economics and Business of the University of Girona (Spain), 06-08 July, 2015. This edition of the conference has been presented with the slogan “Scientific methods for the treatment of uncertainty in social sciences”. There are different ways for dealing with uncertainty in management. The book focuses on soft computing theories and their role in assessing uncertainty in a complex world. It gives a comprehensive overview of quantitative management topics and discusses some of the most recent developments in all the areas of business and management in soft computing including Decision Making, Expert Systems and Forgotten Effects Theory, Forecasting Models, Fuzzy Logic and Fuzzy Sets, Modelling and Simulation Techniques, Neural Networks and Genetic Algorithms and Optimization and Control. The book might be of great interest for anyone working in the area of management and business economics and might be es...

  6. Monitoring Theophylline Concentrations in Saline Using Terahertz ATR Spectroscopy

    Directory of Open Access Journals (Sweden)

    Kei Takeya

    2016-03-01

    Full Text Available To assess the possibility of terahertz technology for the determination of drug concentration in blood, we endeavored to apply a terahertz (THz attenuated total reflection (ATR method to measure the levels of theophylline in saline. A change in reflected THz wave amplitude was observed in a theophylline concentration-dependent manner. This result was obtained with simple measurements of comparisons of the amplitude of the reflected wave, and suggests that it is possible to monitor concentration changes of drugs in liquid material using THz ATR measurements.

  7. Validation of HELIOS for ATR Core Follow Analyses

    Energy Technology Data Exchange (ETDEWEB)

    Bays, Samuel E. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Swain, Emily T. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Crawford, Douglas S. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Nigg, David W. [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2015-03-01

    This work summarizes the validation analyses for the HELIOS code to support core design and safety assurance calculations of the Advanced Test Reactor (ATR). Past and current core safety assurance is performed by the PDQ-7 diffusion code; a state of the art reactor physics simulation tool from the nuclear industry’s earlier days. Over the past twenty years, improvements in computational speed have enabled the use of modern neutron transport methodologies to replace the role of diffusion theory for simulation of complex systems, such as the ATR. More exact methodologies have enabled a paradigm-shift away from highly tuned codes that force compliance with a bounding safety envelope, and towards codes regularly validated against routine measurements. To validate HELIOS, the 16 ATR operational cycles from late-2009 to present were modeled. The computed power distribution was compared against data collected by the ATR’s on-line power surveillance system. It was found that the ATR’s lobe-powers could be determined with ±10% accuracy. Also, the ATR’s cold startup shim configuration for each of these 16 cycles was estimated and compared against the reported critical position from the reactor log-book. HELIOS successfully predicted criticality within the tolerance set by the ATR startup procedure for 13 out of the 16 cycles. This is compared to 12 times for PDQ (without empirical adjustment). These findings, as well as other insights discussed in this report, suggest that HELIOS is highly suited for replacing PDQ for core safety assurance of the ATR. Furthermore, a modern verification and validation framework has been established that allows reactor and fuel performance data to be computed with a known degree of accuracy and stated uncertainty.

  8. Application of ATR-spectroscopy aboard landers: the MATROS experiment

    Science.gov (United States)

    Grigoriev, A.; Coradini, A.; Korablev, O.; Korzhenevskaya, T.; Korolev, Yu.; Gusev, M.; Garbuz, A.; Moshkin, E.; Piccioni, G.; Bellucci, G.; Dibs/Pasteur Team

    We propose to implement the technique of Attenuated Total Reflection (ATR) spectroscopy for in situ studies of planets and small bodies. This method is well-known in laboratory practice (especially in microbiological studies), but so far was not used in space. During descend in an atmosphere an ATR-spectrometer allows investigation of suspended particles -- both solid and liquid. After landing, it can be used for mineralogical studies; on potentially habitable bodies (Mars, Europe) ATR-spectroscopy can be focused on direct detection of living cells. The primary goal of Exo-Mars Pasteur program (2009) is the search for Martian life. We propose for Pasteur the MATROS (Martian Attenuated Total Reflection Optical Spectroscopy) investigation in synergy with DIBS (Drill-Integrated spectrometer) and MIMA (Infrared spectrometer) -- two experiments rated as ``very good'' during preliminary selection. MATROS will perform mineralogical analysis and search for primitive forms of Martian life. Soil samples will be provided from the drill's distribution system. MATROS' hardware consists of a dedicated Mineralogical-Biological Unit (MBU) with multiple hermetic lid and an internal source of radiation (micro-globar). The spectrum of this globar at the output of MATROS modified by ATR absorption will be analyzed by DIBS near infrared spectrometer (0.7-2.8 μ m) and by MIMA Fourier-spectrometer (2.5-20 μ m). Thus the ATR absorption spectra will be measured in the spectral range as wide as 0.7-20 μ m. The measuring sequence is as follows: first, MBU is sterilized by heating up to 100C or more. Then, a sample (actually a bit of mineral powder) will be put into the MBU and analyzed to obtain mineralogical information, including possibly the oxidation degree. After this, some water will be added, and a modification of the ATR spectrum may indicate the presence of clay minerals. Finally, we set up the conditions optimal for culturing of anaerobic autotrophic bacteria (proper temperature

  9. Activation of the ATR kinase by the RPA-binding protein ETAA1

    DEFF Research Database (Denmark)

    Haahr, Peter; Hoffmann, Saskia; Tollenaere, Maxim A X

    2016-01-01

    Activation of the ATR kinase following perturbations to DNA replication relies on a complex mechanism involving ATR recruitment to RPA-coated single-stranded DNA via its binding partner ATRIP and stimulation of ATR kinase activity by TopBP1. Here, we discovered an independent ATR activation pathway...... in vertebrates, mediated by the uncharacterized protein ETAA1 (Ewing's tumour-associated antigen 1). Human ETAA1 accumulates at DNA damage sites via dual RPA-binding motifs and promotes replication fork progression and integrity, ATR signalling and cell survival after genotoxic insults. Mechanistically......, this requires a conserved domain in ETAA1 that potently and directly stimulates ATR kinase activity independently of TopBP1. Simultaneous loss of ETAA1 and TopBP1 gives rise to synthetic lethality characterized by massive genome instability and abrogation of ATR-dependent signalling. Our findings demonstrate...

  10. Recent ATR and fusion algorithm improvements for multiband sonar imagery

    Science.gov (United States)

    Aridgides, Tom; Fernández, Manuel

    2009-05-01

    An improved automatic target recognition processing string has been developed. The overall processing string consists of pre-processing, subimage adaptive clutter filtering, normalization, detection, data regularization, feature extraction, optimal subset feature selection, feature orthogonalization and classification processing blocks. The objects that are classified by the 3 distinct ATR strings are fused using the classification confidence values and their expansions as features, and using "summing" or log-likelihood-ratio-test (LLRT) based fusion rules. The utility of the overall processing strings and their fusion was demonstrated with new high-resolution three-frequency band sonar imagery. The ATR processing strings were individually tuned to the corresponding three-frequency band data, making use of the new processing improvement, data regularization; this improvement entails computing the input data mean, clipping the data to a multiple of its mean and scaling it, prior to feature extraction and resulted in a 3:1 reduction in false alarms. Two significant fusion algorithm improvements were made. First, a nonlinear exponential Box-Cox expansion (consisting of raising data to a to-be-determined power) feature LLRT fusion algorithm was developed. Second, a repeated application of a subset Box-Cox feature selection / feature orthogonalization / LLRT fusion block was utilized. It was shown that cascaded Box-Cox feature LLRT fusion of the ATR processing strings outperforms baseline "summing" and single-stage Box-Cox feature LLRT algorithms, yielding significant improvements over the best single ATR processing string results, and providing the capability to correctly call the majority of targets while maintaining a very low false alarm rate.

  11. Preliminary Discrimination of Butter Adulteration by ATR-FTIR Spectroscopy

    Directory of Open Access Journals (Sweden)

    Lucian Cuibus

    2015-05-01

    Full Text Available The Attenuated Total Reflectance-Fourier Transform Infrared Spectroscopy (ATR-FTIR  was applied for the discrimination of butter samples adulterated with solid fraction of palm oil. For FTIR fingerprinting of butter samples, with or without controlled additions of palm oil as adulterant was firstly obtained, using a Shimatsu Prestige 21 Spectrophotometer, including a horizontal diamond ATR accessory with reflection in the MIR region (3873-690 cm-1.The spiked butter samples including 0 level and seven increasing concentrations of palm fats, up to 50% were fingerprinted and the calibration curve was obtained (n=19. In parallel, the validation was realized using different set of spiked butter samples ranging 1-44.4 % of palm fat (n=7. Finally, an independent set of commercial samples was analized (n=14.Partial least squares (PLS model was used for statistical data processing in accordance with standard method. The value of the correlation coefficient (R2= 0.977 between actual and predicted values was statistically significant (p<0.001, considering the superposition of  "actual vs predicted” curves. This combined FTIR-PLS evaluation revealed that 3 out of  samples of butter were suspected of adulteration with palm oil, presented values 14 ranging 4-12%.In conclusion, ATR-FTIR methodology may offer an rapid evaluation of  butter samples authenticity. The low value for detection limit (3%palm oil in butter and the low limit of quantification (9.8% palm oil in butter confirms that ATR-FTIR spectroscopy  is a sensitive method to identify the adulteration of butter with  palm oil.   

  12. AGR-2 Data Qualification Report for ATR Cycle 154B

    Energy Technology Data Exchange (ETDEWEB)

    Binh Pham; Jeff Einerson

    2014-01-01

    This report provides the data qualification status of Advanced Gas Reactor-2 (AGR-2) fuel irradiation experimental data from Advanced Test Reactor (ATR) Cycle 154B as recorded in the Nuclear Data Management and Analysis System (NDMAS). This is the last cycle of AGR-2 irradiation, as the test train was pulled from the ATR core during the outage portion of ATR Cycle 155A. The AGR-2 data streams addressed in this report include thermocouple (TC) temperatures, sweep gas data (flow rates including new Fission Product Monitoring (FPM) downstream flows from Fission Product Monitoring System (FPMS) detectors, pressure, and moisture content), and FPMS data (release rates and release-to-birth rate ratios [R/Bs]) for each of the six capsules in the AGR-2 experiment. The final data qualification status for these data streams is determined by a Data Review Committee (DRC) comprised of AGR technical leads, Sitewide Quality Assurance (QA), and NDMAS analysts. The Data Review Committee reviewed the data acquisition process, considered whether the data met the requirements for data collection as specified in QA-approved Very High Temperature Reactor (VHTR) data collection plans, examined the results of NDMAS data testing and statistical analyses, and confirmed the qualification status of the data as given in this report.

  13. Natural convection heat transfer analysis of ATR fuel elements

    Energy Technology Data Exchange (ETDEWEB)

    Langerman, M.A.

    1992-05-01

    Natural convection air cooling of the Advanced Test Reactor (ATR) fuel assemblies is analyzed to determine the level of decay heat that can be removed without exceeding the melting temperature of the fuel. The study was conducted to assist in the level 2 PRA analysis of a hypothetical ATR water canal draining accident. The heat transfer process is characterized by a very low Rayleigh number (Ra {approx} 10{sup {minus}5}) and a high temperature ratio. Since neither data nor analytical models were available for Ra < 0.1, an analytical approach is presented based upon the integral boundary layer equations. All assumptions and simplifications are presented and assessed and two models are developed from similar foundations. In one model, the well-known Boussinesq approximations are employed, the results from which are used to assess the modeling philosophy through comparison to existing data and published analytical results. In the other model, the Boussinesq approximations are not used, thus making the model more general and applicable to the ATR analysis.

  14. Immune Response of A Novel ATR-AP205-001 Conjugate Anti-hypertensive Vaccine.

    Science.gov (United States)

    Hu, Xiajun; Deng, Yihuan; Chen, Xiao; Zhou, Yanzhao; Zhang, Hongrong; Wu, Hailang; Yang, Shijun; Chen, Fen; Zhou, Zihua; Wang, Min; Qiu, Zhihua; Liao, Yuhua

    2017-10-03

    We developed a virus-like particle (VLP)-based therapeutic vaccine against angiotensin II receptor type 1, ATR-AP205-001, which could significantly reduce the blood pressure and protect target organs of hypertensive animals. In this study, we focused on the immunological effect and safety of the VLP-based vaccine. By comparing to the depolymerized dimeric vaccine ATR-Dimer-001, we found that ATR-AP205-001 reached subcapsular sinus of lymph node shortly after administration, followed by accumulation on follicle dendritic cells via follicle B cell transportation, while ATR-Dimer-001 vaccine showed no association with FDCs. ATR-AP205-001 vaccine strongly activated dendritic cells, which promoted T cells differentiation to follicular helper T cells. ATR-AP205-001 vaccine induced powerful germinal center reaction, which was translated to a boost of specific antibody production and long-lasting B cell memory, far superior to ATR-Dimer-001 vaccine. Moreover, neither cytotoxic T cells, nor Th1/Th17 cell-mediated inflammation was observed in ATR-AP205-001 vaccine, similar to ATR-Dimer-001 vaccine. We concluded that ATR-AP205-001 vaccine quickly induced potent humoral immunity through collaboration of B cells, follicular dendritic cells and follicular helper T cells, providing an effective and safe intervention for hypertension in the future clinical application.

  15. Transcriptional Regulation of the Daptomycin Gene Cluster in Streptomyces roseosporus by an Autoregulator, AtrA*

    Science.gov (United States)

    Mao, Xu-Ming; Luo, Shuai; Zhou, Ri-Cheng; Wang, Feng; Yu, Pin; Sun, Ning; Chen, Xiao-Xia; Tang, Yi; Li, Yong-Quan

    2015-01-01

    Daptomycin is a cyclic lipopeptide antibiotic produced by Streptomyces roseosporus. To reveal the transcriptional regulatory mechanism of daptomycin biosynthesis, we used the biotinylated dptE promoter (dptEp) as a probe to affinity isolate the dptEp-interactive protein AtrA, a TetR family transcriptional regulator, from the proteome of mycelia. AtrA bound directly to dptEp to positively regulate gene cluster expression and daptomycin production. Meanwhile, both ΔatrA and ΔadpA mutants showed bald phenotype and null production of daptomycin. AdpA positively regulated atrA expression by direct interaction with atrA promoter (atrAp), and removal of ArpA in S. roseosporus, a homolog of the A-factor receptor, resulted in accelerated morphological development and increased daptomycin production, suggesting that atrA was the target of AdpA to mediate the A-factor signaling pathway. Furthermore, AtrA was positively autoregulated by binding to its own promoter atrAp. Thus, for the first time at the transcriptional level, we have identified an autoregulator, AtrA, that directly mediates the A-factor signaling pathway to regulate the proper production of daptomycin. PMID:25648897

  16. Transcriptional regulation of the daptomycin gene cluster in Streptomyces roseosporus by an autoregulator, AtrA.

    Science.gov (United States)

    Mao, Xu-Ming; Luo, Shuai; Zhou, Ri-Cheng; Wang, Feng; Yu, Pin; Sun, Ning; Chen, Xiao-Xia; Tang, Yi; Li, Yong-Quan

    2015-03-20

    Daptomycin is a cyclic lipopeptide antibiotic produced by Streptomyces roseosporus. To reveal the transcriptional regulatory mechanism of daptomycin biosynthesis, we used the biotinylated dptE promoter (dptEp) as a probe to affinity isolate the dptEp-interactive protein AtrA, a TetR family transcriptional regulator, from the proteome of mycelia. AtrA bound directly to dptEp to positively regulate gene cluster expression and daptomycin production. Meanwhile, both ΔatrA and ΔadpA mutants showed bald phenotype and null production of daptomycin. AdpA positively regulated atrA expression by direct interaction with atrA promoter (atrAp), and removal of ArpA in S. roseosporus, a homolog of the A-factor receptor, resulted in accelerated morphological development and increased daptomycin production, suggesting that atrA was the target of AdpA to mediate the A-factor signaling pathway. Furthermore, AtrA was positively autoregulated by binding to its own promoter atrAp. Thus, for the first time at the transcriptional level, we have identified an autoregulator, AtrA, that directly mediates the A-factor signaling pathway to regulate the proper production of daptomycin. © 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

  17. Invited Colloquium--on Publishing in Applied Linguistics: A Forum on Innovation and Challenges in a Changing World, AAAL Conference 2014

    Science.gov (United States)

    Byrnes, Heidi

    2015-01-01

    Under the leadership of then 1st vice president and program chair Aneta Pavlenko, Temple University, the 2014 AAAL conference had as one of its focal areas the changing scene of publishing in a digital and global age. Within an array of offerings addressing the theme, this three-hour invited colloquium, organized by Heidi Byrnes, Georgetown…

  18. E-Learn 2012. World Conference on E-Learning in Corporate, Government, Healthcare, & Higher Education. Proceedings (Montreal, Quebec, Canada, October 9-12, 2012)

    Science.gov (United States)

    Association for the Advancement of Computing in Education, 2012

    2012-01-01

    This year's E-Learn conference has numerous exciting presentations and keynotes. Many speakers will be discussing how education is changing in the forthcoming years. Among them are Dale Stephens who works with the social movement "Uncollege" that empower students to create their own education, Saul Carliner who talks about Massive Online…

  19. Conferinţa Mondială a Populaţiei, Bucureşti 1974. Semnificaţii politice (World Population Conference, Bucharest 1974. Political Meanings

    Directory of Open Access Journals (Sweden)

    Cezar STANCIU

    2014-09-01

    Full Text Available n 1974, the United Nations organized the first inter-governmental conference dedicated especially to problems of population and demography. Apart from technical issue involved, the conference represented yet another manifestation of disagreements between the industrialized countries, on one hand, and the underdeveloped or developing countries. The first group argued that overpopulation was a major risk as the Earth did not have sufficient resources to feed the ever-growing population and birth control measures were required. The latter group disagreed with this perspective and claimed that population issues could be solved only by the development of the poor countries. Development, argued this group of countries, had to be insured by a restructuring of the international economy and more financial assistance from the developed countries. This paper examines Romania’s position in this context, analyzing how the regime in Bucharest tried to balance between foreign constraints such as its obligation as host country to remain neutral, its effort to build bridges to the underdeveloped or developing countries thus trying to tacitly evade it international status of Warsaw Pact member and gain acceptance in the Group of 77. The World Population Conference in 1974 is a conclusive case study for Romania’s foreign policy after the Soviet-American détente of 1972.

  20. Analysis of the ATR fuel element swaging process

    Energy Technology Data Exchange (ETDEWEB)

    Richins, W.D.; Miller, G.K.

    1995-12-01

    This report documents a detailed evaluation of the swaging process used to connect fuel plates to side plates in Advanced Test Reactor (ATR) fuel elements. The swaging is a mechanical process that begins with fitting a fuel plate into grooves in the side plates. Once a fuel plate is positioned, a lip on each of two side plate grooves is pressed into the fuel plate using swaging wheels to form the joints. Each connection must have a specified strength (measured in terms, of a pullout force capacity) to assure that these joints do not fail during reactor operation. The purpose of this study is to analyze the swaging process and associated procedural controls, and to provide recommendations to assure that the manufacturing process produces swaged connections that meet the minimum strength requirement. The current fuel element manufacturer, Babcock and Wilcox (B&W) of Lynchburg, Virginia, follows established procedures that include quality inspections and process controls in swaging these connections. The procedures have been approved by Lockheed Martin Idaho Technologies and are designed to assure repeatability of the process and structural integrity of each joint. Prior to July 1994, ATR fuel elements were placed in the Hydraulic Test Facility (HTF) at the Idaho National Engineering Laboratory (AGNAIL), Test Reactor Area (TRA) for application of Boehmite (an aluminum oxide) film and for checking structural integrity before placement of the elements into the ATR. The results presented in this report demonstrate that the pullout strength of the swaged connections is assured by the current manufacturing process (with several recommended enhancements) without the need for- testing each element in the HTF.

  1. Mislocalization of the MRN complex prevents ATR signaling during adenovirus infection

    DEFF Research Database (Denmark)

    Carson, Christian T; Orazio, Nicole I; Lee, Darwin V

    2009-01-01

    The protein kinases ataxia-telangiectasia mutated (ATM) and ATM-Rad3 related (ATR) are activated in response to DNA damage, genotoxic stress and virus infections. Here we show that during infection with wild-type adenovirus, ATR and its cofactors RPA32, ATRIP and TopBP1 accumulate at viral...... during virus infection, which is independent of Mre11 nuclease activity and recruitment of RPA/ATR/ATRIP/TopBP1. Unlike other damage scenarios, we found that ATM and ATR signaling are not dependent on each other during infection. We identify a region of the viral E4orf3 protein responsible...

  2. ATR Kinase Inhibition Protects Non-cycling Cells from the Lethal Effects of DNA Damage and Transcription Stress*

    Science.gov (United States)

    Kemp, Michael G.; Sancar, Aziz

    2016-01-01

    ATR (ataxia telangiectasia and Rad-3-related) is a protein kinase that maintains genome stability and halts cell cycle phase transitions in response to DNA lesions that block DNA polymerase movement. These DNA replication-associated features of ATR function have led to the emergence of ATR kinase inhibitors as potential adjuvants for DNA-damaging cancer chemotherapeutics. However, whether ATR affects the genotoxic stress response in non-replicating, non-cycling cells is currently unknown. We therefore used chemical inhibition of ATR kinase activity to examine the role of ATR in quiescent human cells. Although ATR inhibition had no obvious effects on the viability of non-cycling cells, inhibition of ATR partially protected non-replicating cells from the lethal effects of UV and UV mimetics. Analyses of various DNA damage response signaling pathways demonstrated that ATR inhibition reduced the activation of apoptotic signaling by these agents in non-cycling cells. The pro-apoptosis/cell death function of ATR is likely due to transcription stress because the lethal effects of compounds that block RNA polymerase movement were reduced in the presence of an ATR inhibitor. These results therefore suggest that whereas DNA polymerase stalling at DNA lesions activates ATR to protect cell viability and prevent apoptosis, the stalling of RNA polymerases instead activates ATR to induce an apoptotic form of cell death in non-cycling cells. These results have important implications regarding the use of ATR inhibitors in cancer chemotherapy regimens. PMID:26940878

  3. UCSB ATR-­NSUF Irradiation DMC Sample Inspection Report

    Energy Technology Data Exchange (ETDEWEB)

    Saleh, Tarik A. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Quintana, Matthew Estevan [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Romero, Tobias J. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2015-02-23

    A variety of tensile samples of Ferritic and Oxide Dispersion Strengthened (ODS or nanoferritic) steels were placed the ATR reactor over 2 Years achieving doses of roughly 4-6 dpa at temperatures of roughly 290°C. After irradiation, samples were shipped from the MFC hot cells at Idaho National Laboratory (INL) to the Wing 9 hot cells in the CMR facility at Los Alamos National Laboratory. Samples were cleaned to removed alpha contamination from the MFC hot cells, and then, as needed removed from their irradiation containers, sorted and inspected. This report will summarize the inspection of the Disc Multipurpose Coupon (DMC) inspection from packet 7-1.

  4. The role of ATR kinase during mammalian gametogenesis

    OpenAIRE

    Pacheco Piñol, Sarai

    2015-01-01

    ATR és una proteïna cinasa essencial per a la viabilitat cel·lular que participa en els mecanismes de resposta al dany en el DNA per tal de mantenir la integritat del genoma. Aquesta proteïna es activada en resposta a regions de cadena simple del DNA (ssDNA) generades per la resecció dels trencaments de doble cadena (DSBs) i controla la progressió de les forques de replicació durant la fase S del cicle cel·lular. Durant la meiosi, un tipus de divisió cel·lular especialitzada per la qual les c...

  5. Quantitative analysis of anti-inflammatory drugs using FTIR-ATR spectrometry

    Science.gov (United States)

    Hassib, Sonia T.; Hassan, Ghaneya S.; El-Zaher, Asmaa A.; Fouad, Marwa A.; Taha, Enas A.

    2017-11-01

    Four simple, accurate, sensitive and economic Attenuated Total Reflectance-Fourier Transform Infrared Spectroscopic (ATR-FTIR) methods have been developed for the quantitative estimation of some non-steroidal anti-inflammatory drugs. The first method involves the determination of Etodolac by direct measurement of the absorbance at 1716 cm- 1. In the second method, the second derivative of the IR spectra of Tolfenamic acid and its reported degradation product (2-chlorobenzoic acid) was used and the amplitudes were measured at 1084.27 cm- 1 and 1056.02 cm- 1 for Tolfenamic acid and 2-chlorobenzoic acid, respectively. The third method used the first derivative of the IR spectra of Bumadizone and its reported degradation product, N,N-diphenylhydrazine and the amplitudes were measured at 2874.98 cm- 1 and 2160.32 cm- 1 for Bumadizone and N,N-diphenylhydrazine, respectively. The fourth method depends on measuring the amplitude of Diacerein at 1059.18 cm- 1 and of rhein, its reported degradation product, at 1079.32 cm- 1 in their first derivative spectra. The four methods were successfully applied on the pharmaceutical formulations by extracting the active constituent in chloroform and the extract was directly measured in liquid phase mode using a specific cell. Moreover, validation of these methods was carried out following International Conference of Harmonisation (ICH) guidelines.

  6. Conference Interpreters

    DEFF Research Database (Denmark)

    Leal Lobato, Ana Isabel

    2017-01-01

    Conference Interpreters: How to serve the cause of minorized communities in the new postmonolingual / ‘postmonodiscoursive’ order,......Conference Interpreters: How to serve the cause of minorized communities in the new postmonolingual / ‘postmonodiscoursive’ order,...

  7. CONFERENCE CALENDAR

    National Research Council Canada - National Science Library

    2014-01-01

    .... 2nd Annual Integrated Health Conference March 20-22, 2015-Town and Country Resort and Convention Center, San Diego, California The Integrated Health Conference provides the latest in integrative...

  8. Conference Planning.

    Science.gov (United States)

    Burke, W. Warner, Ed.; Beckhard, Richard, Ed.

    This book, written to instruct in the use of a conference as a medium of social intercourse, is divided into four sections. Section I, which contains five articles, deals with factors to be considered in planning a conference. Specific techniques one can employ to improve a conference and several different techniques for evaluating the…

  9. The use of ATR-FTIR imaging to study coated oil capsules

    NARCIS (Netherlands)

    Heussen, P.C.M.; Dalen, van G.; Nootenboom, P.; Smit, I.; Duynhoven, van J.P.M.

    2012-01-01

    Fourier transform infrared (FTIR) spectroscopic imaging using a large Internal Reflection Element (IRE), also called Attenuated Total Reflection (ATR) crystal, can be used for the identification and localisation of chemical compounds in solid food products. In this study ATR-FTIR imaging, by means

  10. Australian coal conference

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-06-01

    Almost 600 people attended this year's Australian Coal Conference on Queensland's Gold Coast. The article reports on issues raised at the conference which included the effects of globalisation and the difficulties of raising funds faced by the coal industry and environmental issues. A life cycle analysis of coal's emissions compared to other fuels, released at the conference had demonstrated that coal was a legitimate part of the world's future energy mix. Conference speakers included Michael Pinnock, Queensland Mining Council Chief Executive Officer, Dr Louis Wibberley and Rich Gazzard of BHP, Robin Batterham, the Australian Governments Chief Scientist, Mark Vale, Federal Minister for Trade, Tony Armor of EPRI, Daren Fooks, Clayton Utz Lawyers, Ron Knapp, Chief Executive of the World Coal Institute and Andrew Tucker, Australian Competition and Consumer Commission. Highlights of their addresses are given. Winners of the five research awards presented by the Australian Coal Association at the conference are reported. 11 photos.

  11. Modern approaches in deep learning for SAR ATR

    Science.gov (United States)

    Wilmanski, Michael; Kreucher, Chris; Lauer, Jim

    2016-05-01

    Recent breakthroughs in computational capabilities and optimization algorithms have enabled a new class of signal processing approaches based on deep neural networks (DNNs). These algorithms have been extremely successful in the classification of natural images, audio, and text data. In particular, a special type of DNNs, called convolutional neural networks (CNNs) have recently shown superior performance for object recognition in image processing applications. This paper discusses modern training approaches adopted from the image processing literature and shows how those approaches enable significantly improved performance for synthetic aperture radar (SAR) automatic target recognition (ATR). In particular, we show how a set of novel enhancements to the learning algorithm, based on new stochastic gradient descent approaches, generate significant classification improvement over previously published results on a standard dataset called MSTAR.

  12. Structural Analysis of Spiropyran Polimers using ATR Spectroscopy

    Energy Technology Data Exchange (ETDEWEB)

    Delgado Macui, R; Rojas Lopez, M; Gayou, V L; Orduna Diaz, A [Centro de Investigacion en BiotecnologIa Aplicada del IPN, San Juan de los Molinos km. 1.5 Tepetitla de Lardizabal, A.P. 90700, Tlaxcala (Mexico)

    2006-01-01

    We have used infrared spectroscopy in attenuated total reflection (ATR) mode to analyze the interactions between the polymeric base and solvent with a photochromic material (spyropiran). We used cellulose acetate as polymeric base and the spyropiran; 1,3,3 trimethyl indoline-5-nitro benzopyrane. Thin films with different weight concentrations of SP were deposited in the polymeric base. The infrared spectra show bands whose frequencies are associated to several molecular bondings. It was observed a decreasing in intensity of absorbance for C = O stretching mode of the acetate group at 1720 cm{sup -1} and for C = C stretching mode for the main chain at 823 and 982 cm{sup -1} both associated to the presence of SP in polymeric films.

  13. Feature Fusion Based on Convolutional Neural Network for SAR ATR

    Directory of Open Access Journals (Sweden)

    Chen Shi-Qi

    2017-01-01

    Full Text Available Recent breakthroughs in algorithms related to deep convolutional neural networks (DCNN have stimulated the development of various of signal processing approaches, where the specific application of Automatic Target Recognition (ATR using Synthetic Aperture Radar (SAR data has spurred widely attention. Inspired by the more efficient distributed training such as inception architecture and residual network, a new feature fusion structure which jointly exploits all the merits of each version is proposed to reduce the data dimensions and the complexity of computation. The detailed procedure presented in this paper consists of the fused features, which make the representation of SAR images more distinguishable after the extraction of a set of features from DCNN, followed by a trainable classifier. In particular, the obtained results on the 10-class benchmark data set demonstrate that the presented architecture can achieve remarkable classification performance to the current state-of-the-art methods.

  14. Diagnostic standards for dopaminergic augmentation of restless legs syndrome: report from a World Association of Sleep Medicine-International Restless Legs Syndrome Study Group consensus conference at the Max Planck Institute.

    Science.gov (United States)

    García-Borreguero, Diego; Allen, Richard P; Kohnen, Ralf; Högl, Birgit; Trenkwalder, Claudia; Oertel, Wolfgang; Hening, Wayne A; Paulus, Walter; Rye, David; Walters, Arthur; Winkelmann, Juliane; Earley, Christopher J

    2007-08-01

    Augmentation of symptom severity is the main complication of dopaminergic treatment of restless legs syndrome (RLS). The current article reports on the considerations of augmentation that were made during a European Restless Legs Syndrome Study Group (EURLSSG)-sponsored Consensus Conference in April 2006 at the Max Planck Institute (MPI) in Munich, Germany, the conclusions of which were endorsed by the International RLS Study Group (IRLSSG) and the World Association of Sleep Medicine (WASM). The Consensus Conference sought to develop a better understanding of augmentation and generate a better operational definition for its clinical identification. Current concepts of the pathophysiology, clinical features, and therapy of RLS augmentation were evaluated by subgroups who presented a summary of their findings for general consideration and discussion. Recent data indicating sensitivity and specificity of augmentation features for identification of augmentation were also evaluated. The diagnostic criteria of augmentation developed at the National Institutes of Health (NIH) conference in 2002 were reviewed in light of current data and theoretical understanding of augmentation. The diagnostic value and criteria for each of the accepted features of augmentation were considered by the group. A consensus was then developed for a revised statement of the diagnostic criteria for augmentation. Five major diagnostic features of augmentation were identified: usual time of RLS symptom onset each day, number of body parts with RLS symptoms, latency to symptoms at rest, severity of the symptoms when they occur, and effects of dopaminergic medication on symptoms. The quantitative data available relating the time of RLS onset and the presence of other features indicated optimal augmentation criteria of either a 4-h advance in usual starting time for RLS symptoms or a combination of the occurrence of other features. A paradoxical response to changes in medication dose also indicates

  15. The first UN world conference on women (1975 as a cold war encounter: Recovering anti-imperialist, non-aligned and socialist genealogies

    Directory of Open Access Journals (Sweden)

    Bonfiglioli Chiara

    2016-01-01

    Full Text Available The essay addresses contemporary discussions on women’s transnationalism and women’s agency by looking at the first conference of the UN Decade for Women held in Mexico City in 1975, and at its specific embedding in Cold War geopolitics. Through an engagement with different feminist and activists voices, and particularly with the less visible anti-imperialist, Non-Aligned and socialist genealogies of women’s activism expressed during the meeting, the essay argues that the paradigm of Western feminist knowledge production needs to be revisited, in order to encompass multiple forms of women’s political agency that are not expressed through the liberal framework of women’s individual autonomy from the state. By juxtaposing Betty Friedan’s and Vida Tomšič’s stances during the Mexico City event, the paper shows that women’s political agency during the Cold War era took different forms, which included both the refusal and the acceptance of women’s activism within existing national and international institutions.

  16. The 'diverse, dynamic new world of global tobacco control'? An analysis of participation in the Conference of the Parties to the WHO Framework Convention on Tobacco Control.

    Science.gov (United States)

    Plotnikova, Evgeniya; Hill, Sarah E; Collin, Jeff

    2014-03-01

    The increasingly inequitable impacts of tobacco use highlight the importance of ensuring developing countries' ongoing participation in global tobacco control. The WHO Framework Convention on Tobacco Control (FCTC) has been widely regarded as reflecting the high engagement and effective influence of developing countries. We examined participation in FCTC governance based on records from the first four meetings of the Conference of the Parties (COP), comparing representation and delegate diversity across income levels and WHO regions. While attendance at the COP sessions is high, there are substantial disparities in the relative representation of different income levels and regions, with lower middle and low income countries contributing only 18% and 10% of total meeting delegates, respectively. In regional terms, Europe provided the single largest share of delegates at all except the Durban (2008) meeting. Thirty-nine percent of low income countries and 27% of those from Africa were only ever represented by a single person delegation compared with 10% for high income countries and 11% for Europe. Rotation of the COP meeting location outside of Europe is associated with better representation of other regions and a stronger presence of delegates from national ministries of health and focal points for tobacco control. Developing countries face particular barriers to participating in the COP process, and their engagement in global tobacco control is likely to diminish in the absence of specific measures to support their effective participation.

  17. Nostradamus conference

    CERN Document Server

    Rössler, Otto; Snášel, Václav; Abraham, Ajith; Corchado, Emilio; Nostradamus: Modern Methods of Prediction, Modeling and Analysis of Nonlinear Systems

    2013-01-01

    This proceeding book of Nostradamus conference (http://nostradamus-conference.org) contains accepted papers presented at this event in 2012. Nostradamus conference was held in the one of the biggest and historic city of Ostrava (the Czech Republic, http://www.ostrava.cz/en), in September 2012. Conference topics are focused on classical as well as modern methods for prediction of dynamical systems with applications in science, engineering and economy. Topics are (but not limited to): prediction by classical and novel methods, predictive control, deterministic chaos and its control, complex systems, modelling and prediction of its dynamics and much more.

  18. Mutation of serine 1333 in the ATR HEAT repeats creates a hyperactive kinase.

    Directory of Open Access Journals (Sweden)

    Jessica W Luzwick

    Full Text Available Subcellular localization, protein interactions, and post-translational modifications regulate the DNA damage response kinases ATR, ATM, and DNA-PK. During an analysis of putative ATR phosphorylation sites, we found that a single mutation at S1333 creates a hyperactive kinase. In vitro and in cells, mutation of S1333 to alanine (S1333A-ATR causes elevated levels of kinase activity with and without the addition of the protein activator TOPBP1. S1333 mutations to glycine, arginine, or lysine also create a hyperactive kinase, while mutation to aspartic acid decreases ATR activity. S1333A-ATR maintains the G2 checkpoint and promotes completion of DNA replication after transient exposure to replication stress but the less active kinase, S1333D-ATR, has modest defects in both of these functions. While we find no evidence that S1333 is phosphorylated in cultured cells, our data indicate that small changes in the HEAT repeats can have large effects on kinase activity. These mutants may serve as useful tools for future studies of the ATR pathway.

  19. Evaluation of the AtrAedes™ Lure for Collection of Culex quinquefasciatus in Gravid Traps.

    Science.gov (United States)

    Irish, S R; Batengana, B M; Eiras, A E; Cameron, M M

    2015-03-01

    The typical attractant used in gravid trapping of Culex quinquefasciatus is an aged infusion of organic materials, which can change in attractiveness over time. A standardized chemical attractant dispenser derived from grass infusion, the AtrAedes™ lure, has been produced for the surveillance of the dengue vector Aedes aegypti. A study using this lure in combination with the Centers for Disease Control and Prevention gravid traps was conducted in Tanga, Tanzania. The addition of the lure to traps baited with either grass infusion or tap water did not result in significant increases in trap catch. Grass infusion-baited traps (with and without the AtrAedes lure) collected significantly more Cx. quinquefasciatus than traps baited with AtrAedes + tap water, tap water alone, or AtrAedes alone. The catches of the traps baited with AtrAedes + tap water, tap water alone, and AtrAedes alone were not significantly different from each other. Although the placement of the lure in the base of the trap may have decreased trap catches, it seems that the AtrAedes is not as effective as grass infusion for collecting Cx. quinquefasciatus in Tanzania.

  20. Roles of ATR1 paralogs YMR279c and YOR378w in boron stress tolerance

    OpenAIRE

    BOZDAĞ, Gönensin Ozan; Uluışık, İrem; Gülcüler, Gülce Sıla; Karakaya, Hüseyin Çağlar; KOÇ, Ahmet

    2011-01-01

    Boron is a necessary nutrient for plants and animals, however excess of it causes toxicity. Previously, Atr1 and Arabidopsis Bor1 homolog were identified as the boron efflux pump in yeast, which lower the cytosolic boron concentration and help cells to survive in the presence of toxic amount of boron. In this study, we analyzed ATR1 paralogs, YMR279c and YOR378w, to understand whether they participate in boron stress tolerance in yeast. Even though these genes share homology with ATR1, neithe...

  1. ATR-FTIR as a potential tool for controlling high quality vinegar categories

    DEFF Research Database (Denmark)

    Ríos-Reina, Rocío; Callejón, Raquel M.; Oliver-Pozo, Celia

    2017-01-01

    Characterization of wine vinegars qualified with a Protected Designation of Origin (PDO) is crucial to certify their quality and authenticity. Spectroscopic techniques as Fourier transform mid infrared spectroscopy (FTIR) with Attenuated Total Reflectance (ATR) has been applied to investigate its...

  2. Montana Weigh-in-Motion (WIM) and Automatic Traffic Recorder (ATR) Strategy Final Report

    Science.gov (United States)

    2017-03-01

    The objective of this project was to review the Montana Department of Transportations (MDTs) permanent Weigh-in-Motion (WIM) and Automated Traffic Recorder (ATR) data collection programs to ensure they are efficiently providing the best possibl...

  3. Encefalomenigocele atrésico parietal Parietal atresic encephalomeningocele

    Directory of Open Access Journals (Sweden)

    Liliana Rivera Oliva

    2011-09-01

    Full Text Available El encefalocele es una anomalía congénita rara, en la que una porción del encéfalo protruye a través de un orificio craneal (evaginación, generalmente situado en la línea media. Clínicamente se caracteriza por una masa epicraneal, de consistencia blanda, muchas veces acompañada de trastornos psicomotores, convulsiones y trastornos de la visión. Se presenta el caso de un recién nacido con diagnóstico de encefalomeningocele atrésico parietal, intervenido quirúrgicamente y con evolución satisfactoria.The encephalocele is a uncommon congenital anomaly where a portion of encephalon protrudes through a cranial orifice (evagination, generally located in the middle line. Clinically, it is characterized by a soft epicranial mass often accompanied or psychomotor disorders, convulsions and vision disorders. This is the case of a newborn diagnosed with parietal atresic encephalomeningocele operated on with a satisfactory evolution.

  4. Experimental active control of sound in the ATR 42

    Science.gov (United States)

    Paonessa, A.; Sollo, A.; Paxton, M.; Purver, M.; Ross, C. F.

    Passenger comfort is becoming day by day an important issue for the market of the regional turboprop aircraft and also for the future high speed propeller driven aircraft. In these aircraft the main contribution to the passenger annoyance is due to the propeller noise blade passing frequency (BPF) and its harmonics. In the recent past a detailed theoretical and experimental work has been done by Alenia Aeronautica in order to reduce the noise level in the ATR aircraft passenger cabin by means of conventional passive treatments: synchrophasing of propellers, dynamic vibration absorbers, structural reinforcements, damping materials. The application of these treatments has been introduced on production aircraft with a remarkable improvement of noise comfort but with a significant weight increase. For these reasons, a major technology step is required for reaching passenger comfort comparable to that of jet aircraft with the minimum weight increase. The most suitable approach to this problem has been envisaged in the active noise control which consists in generating an anti-sound field in the passenger cabin to reduce the noise at propeller BPF and its harmonics. The attenuation is reached by means of a control system which acquires information about the cabin noise distribution and the propeller speed during flight and simultaneously generates the signals to drive the speakers.

  5. Neutron dosimetry and damage calculations for the ATR-A1 irradiation

    Energy Technology Data Exchange (ETDEWEB)

    Greenwood, L.R.; Ratner, R.T. [Pacific Northwest National Lab., Richland, WA (United States)

    1998-09-01

    Neutron fluence measurements and radiation damage calculations are reported for the collaborative US/Japan ATR-A1 irradiation in the Advanced Test Reactor (ATR) at Idaho National Engineering Laboratory (INEL). The maximum total neutron fluence at midplane was 9.4 {times} 10{sup 21} n/cm{sup 2} (5.5 {times} 10{sup 21} n/cm{sup 2} above 0.1 MeV), resulting in about 4.6 dpa in vanadium.

  6. 28th Linear Accelerator Conference

    CERN Document Server

    Facco, Alberto; McCausey, Amy; Schaa, Volker R W

    2017-01-01

    The 28th Linear Accelerator Conference, LINAC 16, to take place at the Kellogg Hotel and Conference Center in East Lansing, Michigan, on 25-30 September 2016. This conference is the main bi-yearly gathering for the world-wide community of linac specialists. It provides a unique opportunity to hear about the latest advances of projects and developments concerning hadron and lepton linacs, and their applications. In the tradition of previous LINAC conferences, plenary sessions including invited speakers are scheduled every day. Poster sessions will be held on Monday, Tuesday and Thursday afternoons. There will also be two special events on Sunday, 25 September 2016, namely a student poster session and an evening reception for registrants and their companions at the Kellogg Hotel and Conference Center. Participants are also warmly invited to join an outing to Lake Michigan and the beautiful surroundings on Wednesday afternoon, and to visit the Facility for Rare Isotope Beams on Friday afternoon, after the formal...

  7. ATM and ATR Signaling Regulate the Recruitment of Human Telomerase to Telomeres

    Directory of Open Access Journals (Sweden)

    Adrian S. Tong

    2015-11-01

    Full Text Available The yeast homologs of the ATM and ATR DNA damage response kinases play key roles in telomerase-mediated telomere maintenance, but the role of ATM/ATR in the mammalian telomerase pathway has been less clear. Here, we demonstrate the requirement for ATM and ATR in the localization of telomerase to telomeres and telomere elongation in immortal human cells. Stalled replication forks increased telomerase recruitment in an ATR-dependent manner. Furthermore, increased telomerase recruitment was observed upon phosphorylation of the shelterin component TRF1 at an ATM/ATR target site (S367. This phosphorylation leads to loss of TRF1 from telomeres and may therefore increase replication fork stalling. ATM and ATR depletion reduced assembly of the telomerase complex, and ATM was required for telomere elongation in cells expressing POT1ΔOB, an allele of POT1 that disrupts telomere-length homeostasis. These data establish that human telomerase recruitment and telomere elongation are modulated by DNA-damage-transducing kinases.

  8. Cancer-Specific Synthetic Lethality between ATR and CHK1 Kinase Activities

    Directory of Open Access Journals (Sweden)

    Kumar Sanjiv

    2016-01-01

    Full Text Available ATR and CHK1 maintain cancer cell survival under replication stress and inhibitors of both kinases are currently undergoing clinical trials. As ATR activity is increased after CHK1 inhibition, we hypothesized that this may indicate an increased reliance on ATR for survival. Indeed, we observe that replication stress induced by the CHK1 inhibitor AZD7762 results in replication catastrophe and apoptosis, when combined with the ATR inhibitor VE-821 specifically in cancer cells. Combined treatment with ATR and CHK1 inhibitors leads to replication fork arrest, ssDNA accumulation, replication collapse, and synergistic cell death in cancer cells in vitro and in vivo. Inhibition of CDK reversed replication stress and synthetic lethality, demonstrating that regulation of origin firing by ATR and CHK1 explains the synthetic lethality. In conclusion, this study exemplifies cancer-specific synthetic lethality between two proteins in the same pathway and raises the prospect of combining ATR and CHK1 inhibitors as promising cancer therapy.

  9. Achilles Tendon Reflex (ATR) in response to short exposures of microgravity and hypergravity

    Science.gov (United States)

    Fujii, M.; Jaweed, M.

    1992-01-01

    Previous studies indicate that latency and amplitude of the Achilles tendon reflex (ATR) are reduced after exposure to microgravity for 28 days. The objective of this study was to quantitatively measure the latency of ATR during brief (20 sec) exposure to microgravity in KC-135 parabolic flights. Methods: The ATR was elicited in ten men during parabolic flight with the ankle held neutrally, planarflexed, and dorsiflexed. During flight, the ATR was elicited during the zero G and 1.8 G phases. Postflight testing was performed flying back to the airfield. Latencies to onset of the ATR were calculated and analyses of variance were performed to determine the effect of gravity and ankle position on latency. Result: The mean latencies for zero-G, 1.8-G and postflight with the ankle in the neutral position were 32.7 plus or minus 0.5 ms, and 33.1 plus or minus 0.7 ms respectively, which were not significantly different. There was a trend toward prolongation of latencies postflight. The mean latency for those who were motion sick was 32.1 plus or minus 0.1 ms compared to 34.0 plus or minus 0.3 ms for those who were not sick. Conclusions: These studies indicate that neither the level of gravity nor ankle position significantly affected the latency of the ATR.

  10. CONFERENCE REPORTS

    African Journals Online (AJOL)

    Test

    imagining. Psychology in Africa. She asserted that psychology is very important in society because it brings out human perceptions and attitudes. In a unique keynote presentation, Sean Hagen, a lecturer at UNISA who organised the conference ...

  11. Untangling the ATR-CHEK1 network for prognostication, prediction and therapeutic target validation in breast cancer.

    Science.gov (United States)

    Abdel-Fatah, Tarek M A; Middleton, Fiona K; Arora, Arvind; Agarwal, Devika; Chen, Tao; Moseley, Paul M; Perry, Christina; Doherty, Rachel; Chan, Stephen; Green, Andrew R; Rakha, Emad; Ball, Graham; Ellis, Ian O; Curtin, Nicola J; Madhusudan, Srinivasan

    2015-03-01

    ATR-CHEK1 signalling is critical for genomic stability. ATR-CHEK1 signalling may be deregulated in breast cancer and have prognostic, predictive and therapeutic significance. We investigated ATR, CHEK1 and phosphorylated CHEK1 (Ser345) protein (pCHEK1) levels in 1712 breast cancers. ATR and CHEK1 mRNA expression was evaluated in 1950 breast cancers. Pre-clinically, biological consequences of ATR gene knock down or ATR inhibition by the small molecule inhibitor (VE-821) were investigated in MCF7 and MDA-MB-231 breast cancer cell lines and in non-tumorigenic breast epithelial cells (MCF10A). High ATR and high cytoplasmic pCHEK1 levels were significantly associated with higher tumour stage, higher mitotic index, pleomorphism and lymphovascular invasion. In univariate analyses, high ATR and high cytoplasmic pCHEK1 levels were associated with poor breast cancer specific survival (BCSS). In multivariate analysis, high ATR level remains an independent predictor of adverse outcome. At the mRNA level, high CHEK1 remains associated with aggressive phenotypes including lymph node positivity, high grade, Her-2 overexpression, triple negative, aggressive molecular phenotypes and adverse BCSS. Pre-clinically, CHEK1 phosphorylation at serine(345) following replication stress was impaired in ATR knock down and in VE-821 treated breast cancer cells. Doxycycline inducible knockdown of ATR suppressed growth, which was restored when ATR was re-expressed. Similarly, VE-821 treatment resulted in a dose dependent suppression of cancer cell growth and survival (MCF7 and MDA-MB-231) but was less toxic in non-tumorigenic breast epithelial cells (MCF10A). We provide evidence that ATR and CHEK1 are promising biomarkers and rational drug targets for personalized therapy in breast cancer. Copyright © 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

  12. Conference on Environmental Data Management

    CERN Document Server

    Oppenheimer, Dorothy; Brogden, William; Environmental Data Management

    1976-01-01

    Throughout the world a staggering amount of resources have been used to obtain billions of environmental data points. Some, such as meteorological data, have been organized for weather map display where many thousands of data points are synthesized in one compressed map. Most environmental data, however, are still widely scattered and generally not used for a systems approach, but only for the purpose for which they were originally taken. These data are contained in relatively small computer programs, research files, government and industrial reports, etc. This Conference was called to bring together some of the world's leaders from research centers and government agencies, and others concerned with environmental data management. The purpose of the Conference was to organize discussion on the scope of world environmental data, its present form and documentation, and whether a systematic approach to a total system is feasible now or in the future. This same subject permeated indirectly the Stockholm Conference...

  13. Conference Video for Booth at SAE World Congress Experience Conference

    Science.gov (United States)

    Harkey, Ann Marie

    2017-01-01

    Contents: Publicly released videos on technology transfer items available for licensing from NASA. Includes; Powder Handling Device for Analytical Instruments (Ames); 2. Fiber Optic Shape Sensing (FOSS) (Armstrong); 3. Robo-Glove (Johnson); 4. Modular Robotic Vehicle (Johnson); 5. Battery Management System (Johnson); 6. Active Response Gravity Offload System (ARGOS) (Johnson); 7. Contaminant Resistant Coatings for Extreme Environments (Langley); 8. Molecular Adsorber Coating (MAC) (Goddard); 9. Ultrasonic Stir Welding (Marshall). Also includes scenes from the International Space Station.

  14. Learning in a technology enhanced world

    NARCIS (Netherlands)

    Specht, Marcus

    2010-01-01

    Specht, M. (2009). Learning in a technology enhanced world. Invited talk given at the World Conference on E-learning in Corporate, Government, Healthcare & Higher Education. October, 27, 2009, Vancouver, Canada.

  15. Mendel conference

    CERN Document Server

    2015-01-01

    This book is a collection of selected accepted papers of Mendel conference that has been held in Brno, Czech Republic in June 2015. The book contents three chapters which represent recent advances in soft computing including intelligent image processing and bio-inspired robotics.: Chapter 1: Evolutionary Computing, and Swarm intelligence, Chapter 2: Neural Networks, Self-organization, and Machine Learning, and Chapter3: Intelligent Image Processing, and Bio-inspired Robotics. The Mendel conference was established in 1995, and it carries the name of the scientist and Augustinian priest Gregor J. Mendel who discovered the famous Laws of Heredity. In 2015 we are commemorating 150 years since Mendel's lectures, which he presented in Brno on February and March 1865. The main aim of the conference was to create a periodical possibility for students, academics and researchers to exchange their ideas and novel research methods.  .

  16. CERN automatic audio-conference service

    CERN Document Server

    Sierra Moral, R

    2010-01-01

    Scientists from all over the world need to collaborate with CERN on a daily basis. They must be able to communicate effectively on their joint projects at any time; as a result telephone conferences have become indispensable and widely used. Managed by 6 operators, CERN already has more than 20000 hours and 5700 audio-conferences per year. However, the traditional telephone based audio-conference system needed to be modernized in three ways. Firstly, to provide the participants with more autonomy in the organization of their conferences; secondly, to eliminate the constraints of manual intervention by operators; and thirdly, to integrate the audio-conferences into a collaborative working framework. The large number, and hence cost, of the conferences prohibited externalization and so the CERN telecommunications team drew up a specification to implement a new system. It was decided to use a new commercial collaborative audio-conference solution based on the SIP protocol. The system was tested as the first Euro...

  17. CERN automatic audio-conference service

    CERN Multimedia

    Sierra Moral, R

    2009-01-01

    Scientists from all over the world need to collaborate with CERN on a daily basis. They must be able to communicate effectively on their joint projects at any time; as a result telephone conferences have become indispensable and widely used. Managed by 6 operators, CERN already has more than 20000 hours and 5700 audio-conferences per year. However, the traditional telephone based audio-conference system needed to be modernized in three ways. Firstly, to provide the participants with more autonomy in the organization of their conferences; secondly, to eliminate the constraints of manual intervention by operators; and thirdly, to integrate the audio-conferences into a collaborative working framework. The large number, and hence cost, of the conferences prohibited externalization and so the CERN telecommunications team drew up a specification to implement a new system. It was decided to use a new commercial collaborative audio-conference solution based on the SIP protocol. The system was tested as the first Euro...

  18. In-situ ATR-FTIR for characterization of thin biorelated polymer films

    Energy Technology Data Exchange (ETDEWEB)

    Müller, M., E-mail: mamuller@ipfdd.de [Leibniz Institute of Polymer Research Dresden (IPF Dresden), Hohe Straße 6, 01069 Dresden (Germany); Technical University of Dresden (TUD), Department of Chemistry and Food Chemistry, 01062 Dresden (Germany); Torger, B. [Leibniz Institute of Polymer Research Dresden (IPF Dresden), Hohe Straße 6, 01069 Dresden (Germany); Technical University of Dresden (TUD), Department of Chemistry and Food Chemistry, 01062 Dresden (Germany); Bittrich, E. [Leibniz Institute of Polymer Research Dresden (IPF Dresden), Hohe Straße 6, 01069 Dresden (Germany); Kaul, E.; Ionov, L. [Leibniz Institute of Polymer Research Dresden (IPF Dresden), Hohe Straße 6, 01069 Dresden (Germany); Technical University of Dresden (TUD), Department of Chemistry and Food Chemistry, 01062 Dresden (Germany); Uhlmann, P. [Leibniz Institute of Polymer Research Dresden (IPF Dresden), Hohe Straße 6, 01069 Dresden (Germany); Stamm, M. [Leibniz Institute of Polymer Research Dresden (IPF Dresden), Hohe Straße 6, 01069 Dresden (Germany); Technical University of Dresden (TUD), Department of Chemistry and Food Chemistry, 01062 Dresden (Germany)

    2014-04-01

    We present and review in-situ-attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopic data from thin biorelated polymer films useful for the modification and functionalization of polymer and inorganic materials and discuss their applications related to life sciences. A special ATR mirror attachment operated by the single-beam-sample-reference (SBSR) concept and housing a homebuilt thermostatable flow cell was used, which allows for appropriate background compensation and signal to noise ratio. ATR-FTIR data on the reactive deposition of dopamine on inorganic model surfaces are shown. Information on the structure and deposition pathway for such bioinspired melanin-like films is provided. ATR-FTIR data on thermosensitive polymer brushes of poly(N-isopropylacrylamide) (PNIPAAM) is then presented. The thermotropic hydration and hydrogen bonding behavior of PNIPAAM brush films is described. Finally, ATR-FTIR data on biorelated polyelectrolyte multilayers (PEM) are given together with details on PEM growth and detection. Applications of these latter films for biopassivation/activation and local drug delivery are addressed.

  19. The essential kinase ATR: ensuring faithful duplication of a challenging genome.

    Science.gov (United States)

    Saldivar, Joshua C; Cortez, David; Cimprich, Karlene A

    2017-10-01

    One way to preserve a rare book is to lock it away from all potential sources of damage. Of course, an inaccessible book is also of little use, and the paper and ink will continue to degrade with age in any case. Like a book, the information stored in our DNA needs to be read, but it is also subject to continuous assault and therefore needs to be protected. In this Review, we examine how the replication stress response that is controlled by the kinase ataxia telangiectasia and Rad3-related (ATR) senses and resolves threats to DNA integrity so that the DNA remains available to read in all of our cells. We discuss the multiple data that have revealed an elegant yet increasingly complex mechanism of ATR activation. This involves a core set of components that recruit ATR to stressed replication forks, stimulate kinase activity and amplify ATR signalling. We focus on the activities of ATR in the control of cell cycle checkpoints, origin firing and replication fork stability, and on how proper regulation of these processes is crucial to ensure faithful duplication of a challenging genome.

  20. XIX Edoardo Amaldi Conference

    CERN Document Server

    Abousahl, Said; Plastino, Wolfango

    2016-01-01

    This book, comprising contributions presented at the XIX Edoardo Amaldi Conference, examines important aspects of international cooperation aimed at enhancing nuclear safety, security, safeguards (the “3S”), and non-proliferation, thereby assisting in the development and maintenance of the verification regime and progress toward a nuclear weapon-free world. The Conference served as a forum where eminent scientists, diplomats, and policymakers could compare national perspectives and update international collaborations. The book opens by addressing the political, institutional, and legal dimensions of the 3S and non-proliferation; current challenges are discussed and attempts made to identify possible solutions and future improvements. Subsequent sections consider scientific developments that can contribute to increased effectiveness in the implementation of international regimes, particularly in critical areas, technology foresight, and the ongoing evaluation of current capabilities. The closing sections d...

  1. Conference Report: CAQD Conference 2013

    Directory of Open Access Journals (Sweden)

    Christina Silver

    2013-05-01

    Full Text Available Nestled on the banks of the river Lahn in central Germany, the 15th CAQD conference was held at Marburg. A beautiful provincial town, it is one of very few that was spared the bombings of WWII; now providing the perfect backdrop for meeting to discuss developments in qualitative technology. This was the second international conference in the series with more than 140 delegates from 14 countries, including: Canada, Brazil, Portugal, the UK, as well as Germany. Hosted by MAGMA, the Marburg Research Group for Methodology and Evaluation, in partnership with Philipps-University Marburg, CAQD prioritizes a user-focus which balances practical and methodological workshops with conference presentations. URN: http://nbn-resolving.de/urn:nbn:de:0114-fqs1302249

  2. Consensus conferences

    DEFF Research Database (Denmark)

    Nielsen, Annika Porsborg; Lassen, Jesper

    , the differing perceptions are each in their own way rooted in an argument for democratic legitimacy. We therefore argue that national interpretations of consensus conferences, and of their ability to functions as a tool for public participation, depend to a great extent on the dominant ideals of democratic...

  3. Conference Summary

    Science.gov (United States)

    Harrington, James L., Jr.

    2000-01-01

    Celebrations and special events were in order this year as the Minority University-Space Interdisciplinary Network (MU-SPIN) Program and NASA's Minority University Research and Education Division (MURED) both reached their 10th anniversaries. In honor of this occasion, the 2000 Annual Users' Conference held at Morris Brown College (MBC) in Atlanta, Georgia, September 11-15, 2000, was the first to be jointly hosted by MU-SPIN and MURED. It was particularly fitting that this anniversary should fall in the year 2000. The start of the new millennium propelled us to push bold new ideas and renew our commitment to minority university participation in all areas of NASA. With the theme 'Celebrating Our Tenth Year With Our Eyes on the Prize,' the conference provided a national forum for showcasing successful MU-SPIN and MURED Program (MUREP) experiences to enhance faculty/student development in areas of scientific and technical research and education. Our NASA-relevant conference agenda resulted in a record-breaking 220 registered attendees. Using feedback from past participants, we designed a track of student activities closely tailored to their interests. The resulting showcase of technical assistance and best practices set a new standard for our conferences in the years to come. This year's poster session was our largest ever, with over 50 presentations from students, faculty, and teachers. Posters covered a broad range of NASA activities from 'A Study of the Spiral Galaxy M101' to 'Network Cabling Characteristics.'

  4. Conference report

    African Journals Online (AJOL)

    Tamara Shefer

    poster presentations on numerous disciplines, including: epidemiology, preventive medicine, public health, social ... The conference theme “from research to implementation” emphasised the importance of ... sustainable implementation were addressed in an honest and nuanced manner, leaving me with a sense of trouble ...

  5. CONFERENCE REPORTS

    African Journals Online (AJOL)

    Dr. Marfo

    dinner and, at this dinner, socialization was at its best, with some music and dancing and presentation of gifts from the host university. Some members of the .... Jean Monnet, a student hostel with conference facilities where most of the participants also stayed. The third and fourth days' sessions were held at the INALCO ...

  6. 10. international mouse genome conference

    Energy Technology Data Exchange (ETDEWEB)

    Meisler, M.H.

    1996-12-31

    Ten years after hosting the First International Mammalian Genome Conference in Paris in 1986, Dr. Jean-Louis Guenet presided over the Tenth Conference at the Pasteur Institute, October 7--10, 1996. The 1986 conference was a satellite to the Human Gene Mapping Workshop and had approximately 50 attendees. The 1996 meeting was attended by 300 scientists from around the world. In the interim, the number of mapped loci in the mouse increased from 1,000 to over 20,000. This report contains a listing of the program and its participants, and two articles that review the meeting and the role of the laboratory mouse in the Human Genome project. More than 200 papers were presented at the conference covering the following topics: International mouse chromosome committee meetings; Mutant generation and identification; Physical and genetic maps; New technology and resources; Chromatin structure and gene regulation; Rate and hamster genetic maps; Informatics and databases; and Quantitative trait analysis.

  7. EDITORIAL: International MEMS Conference 2006

    Science.gov (United States)

    Tay, Francis E. H.; Jianmin, Miao; Iliescu, Ciprian

    2006-04-01

    The International MEMS conference (iMEMS2006) organized by the Institute of Bioengineering and Nanotechnology and Nanyang Technological University aims to provide a platform for academicians, professionals and industrialists in various related fields from all over the world to share and learn from each other. Of great interest is the incorporation of the theme of life sciences application using MEMS. It is the desire of this conference to initiate collaboration and form network of cooperation. This has continued to be the objective of iMEMS since its inception in 1997. The technological advance of MEMS over the past few decades has been truly exciting in terms of development and applications. In order to participate in this rapid development, a conference involving delegates from within the MEMS community and outside the community is very meaningful and timely. With the receipt of over 200 articles, delegates related to MEMS field from all over the world will share their perspectives on topics such as MEMS/MST Design, MEMS Teaching and Education, MEMS/MST Packaging, MEMS/MST Fabrication, Microsystems Applications, System Integration, Wearable Devices, MEMSWear and BioMEMS. Invited speakers and delegates from outside the field have also been involved to provide challenges, especially in the life sciences field, for the MEMS community to potentially address. The proceedings of the conference will be published as an issue in the online Journal of Physics: Conference Series and this can reach a wider audience and will facilitate the reference and citation of the work presented in the conference. We wish to express our deep gratitude to the International Scientific Committee members and the organizing committee members for contributing to the success of this conference. We would like to thank all the delegates, speakers and sponsors from all over the world for presenting and sharing their perspectives on topics related to MEMS and the challenges that MEMS can

  8. Seeded growth fabrication of Cu-on-Si electrodes for in situ ATR-SEIRAS applications

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Hui-Feng [Shanghai Key Laboratory for Molecular Catalysis and Innovative Materials and Department of Chemistry, Fudan University, Shanghai 200433 (China); Yan, Yan-Gang [Shanghai Key Laboratory for Molecular Catalysis and Innovative Materials and Department of Chemistry, Fudan University, Shanghai 200433 (China); Huo, Sheng-Juan [Shanghai Key Laboratory for Molecular Catalysis and Innovative Materials and Department of Chemistry, Fudan University, Shanghai 200433 (China); Cai, Wen-Bin [Shanghai Key Laboratory for Molecular Catalysis and Innovative Materials and Department of Chemistry, Fudan University, Shanghai 200433 (China); Department of Enviromental Engineering, Shanghai University of Electric Power, Shanghai 200090 (China); E-mail: wbcai@fudan.edu.cn; Xu, Qun-Jie [Department of Enviromental Engineering, Shanghai University of Electric Power, Shanghai 200090 (China); Osawa, Masatoshi [Catalysis Research Center, Hokkaido University, Sapporo 001-0021 (Japan)

    2007-05-25

    A seeded-growth approach has been developed to fabricate a Cu nanoparticle film (simplified hereafter with nanofilm) on Si for electrochemical ATR surface-enhanced infrared absorption spectroscopy (ATR-SEIRAS). The approach comprises an initial activation of the reflecting plane of hemicylindrical Si prism by introducing a Cu seed layer in a CuSO{sub 4}-HF solution and the subsequent electroless deposition of the Cu nanofilms from an electroless Cu plating bath. The as-deposited Cu nanofilm exhibited strong SEIRA effect for the CO probe and interfacial free H{sub 2}O. ATR-SEIRAS was also applied to characterize the adsorbed geometries of pyridine at the Cu/electrolyte interface. Only vibrational bands assignable to the A {sub 1} symmetry modes were detected in the entire potential window investigated, suggestive of an end-on adsorption via the ring N-atom on a Cu electrode.

  9. ATM, ATR, and DNA-PK: The Trinity at the Heart of the DNA Damage Response.

    Science.gov (United States)

    Blackford, Andrew N; Jackson, Stephen P

    2017-06-15

    In vertebrate cells, the DNA damage response is controlled by three related kinases: ATM, ATR, and DNA-PK. It has been 20 years since the cloning of ATR, the last of the three to be identified. During this time, our understanding of how these kinases regulate DNA repair and associated events has grown profoundly, although major questions remain unanswered. Here, we provide a historical perspective of their discovery and discuss their established functions in sensing and responding to genotoxic stress. We also highlight what is known regarding their structural similarities and common mechanisms of regulation, as well as emerging non-canonical roles and how our knowledge of ATM, ATR, and DNA-PK is being translated to benefit human health. Copyright © 2017 Elsevier Inc. All rights reserved.

  10. 10 CFR 830 Major Modification Determination for Replacement of ATR Primary Coolant Pumps and Motors

    Energy Technology Data Exchange (ETDEWEB)

    Noel Duckwitz

    2011-05-01

    The continued safe and reliable operation of the ATR is critical to the Department of Energy (DOE) Office of Nuclear Energy (NE) mission. While ATR is safely fulfilling current mission requirements, a variety of aging and obsolescence issues challenge ATR engineering and maintenance personnel’s capability to sustain ATR over the long term. First documented in a series of independent assessments, beginning with an OA Environmental Safety and Health Assessment conducted in 2003, the issues were validated in a detailed Material Condition Assessment (MCA) conducted as a part of the ATR Life Extension Program in 2007.Accordingly, near term replacement of aging and obsolescent original ATR equipment has become important to ensure ATR capability in support of NE’s long term national missions. To that end, a mission needs statement has been prepared for a non-major system acquisition which is comprised of three interdependent subprojects. The first project will replace the existent diesel-electrical bus (E-3), switchgear, and the 50-year-old obsolescent marine diesels with commercial power that is backed with safety related emergency diesel generators, switchgear, and uninterruptible power supply (UPS). The second project, the subject of this major modification determination, will replace the four, obsolete, original primary coolant pumps (PCPs) and motors. Completion of this and the two other age-related projects (replacement of the ATR diesel bus [E-3] and switchgear and replacement of the existent emergency firewater injection system) will resolve major age-related operational issues plus make a significant contribution in sustaining the ATR safety and reliability profile. The major modification criteria evaluation of the project pre-conceptual design identified several issues that lead to the conclusion that the project is a major modification: 1. Evaluation Criteria #3 (Change of existing process). The proposed strategy for equipping the replacement PCPs with VFDs

  11. Status of ATR-A1 irradiation experiment on vanadium alloys and low-activation steels

    Energy Technology Data Exchange (ETDEWEB)

    Tsai, H.; Strain, R.V.; Gomes, I.; Smith, D.L. [Argonne National Lab., IL (United States); Matsui, H. [Tohoku Univ. (Japan)

    1996-10-01

    The ATR-A1 irradiation experiment was a collaborative U.S./Japan effort to study at low temperature the effects of neutron damage on vanadium alloys. The experiment also contained a limited quantity of low-activation ferritic steel specimens from Japan as part of the collaboration agreement. The irradiation started in the Advanced Test Reactor (ATR) on November 30, 1995, and ended as planned on May 5, 1996. Total exposure was 132.9 effective full power days (EFPDs) and estimated neutron damage in the vanadium was 4.7 dpa. The vehicle has been discharged from the ATR core and is scheduled to be disassembled in the next reporting period.

  12. Measured Thermal and Fast Neutron Fluence Rates for ATF-1 Holders During ATR Cycle 157D

    Energy Technology Data Exchange (ETDEWEB)

    Smith, Larry Don [Idaho National Lab. (INL), Idaho Falls, ID (United States); Miller, David Torbet [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2016-03-01

    This report contains the thermal (2200 m/s) and fast (E>1MeV) neutron fluence rate data for the ATF-1 holders located in core for ATR Cycle 157D which were measured by the Radiation Measurements Laboratory (RML) as requested by the Power Reactor Programs (ATR Experiments) Radiation Measurements Work Order. This report contains measurements of the fluence rates corresponding to the particular elevations relative to the 80-ft. core elevation. The data in this report consist of (1) a table of the ATR power history and distribution, (2) a hard copy listing of all thermal and fast neutron fluence rates, and (3) plots of both the thermal and fast neutron fluence rates. The fluence rates reported are for the average power levels given in the table of power history and distribution.

  13. SAR image dataset of military ground targets with multiple poses for ATR

    Science.gov (United States)

    Belloni, Carole; Balleri, Alessio; Aouf, Nabil; Merlet, Thomas; Le Caillec, Jean-Marc

    2017-10-01

    Automatic Target Recognition (ATR) is the task of automatically detecting and classifying targets. Recognition using Synthetic Aperture Radar (SAR) images is interesting because SAR images can be acquired at night and under any weather conditions, whereas optical sensors operating in the visible band do not have this capability. Existing SAR ATR algorithms have mostly been evaluated using the MSTAR dataset.1 The problem with the MSTAR is that some of the proposed ATR methods have shown good classification performance even when targets were hidden,2 suggesting the presence of a bias in the dataset. Evaluations of SAR ATR techniques are currently challenging due to the lack of publicly available data in the SAR domain. In this paper, we present a high resolution SAR dataset consisting of images of a set of ground military target models taken at various aspect angles, The dataset can be used for a fair evaluation and comparison of SAR ATR algorithms. We applied the Inverse Synthetic Aperture Radar (ISAR) technique to echoes from targets rotating on a turntable and illuminated with a stepped frequency waveform. The targets in the database consist of four variants of two 1.7m-long models of T-64 and T-72 tanks. The gun, the turret position and the depression angle are varied to form 26 different sequences of images. The emitted signal spanned the frequency range from 13 GHz to 18 GHz to achieve a bandwidth of 5 GHz sampled with 4001 frequency points. The resolution obtained with respect to the size of the model targets is comparable to typical values obtained using SAR airborne systems. Single polarized images (Horizontal-Horizontal) are generated using the backprojection algorithm.3 A total of 1480 images are produced using a 20° integration angle. The images in the dataset are organized in a suggested training and testing set to facilitate a standard evaluation of SAR ATR algorithms.

  14. APE2 is required for ATR-Chk1 checkpoint activation in response to oxidative stress.

    Science.gov (United States)

    Willis, Jeremy; Patel, Yogin; Lentz, Barry L; Yan, Shan

    2013-06-25

    The base excision repair pathway is largely responsible for the repair of oxidative stress-induced DNA damage. However, it remains unclear how the DNA damage checkpoint is activated by oxidative stress at the molecular level. Here, we provide evidence showing that hydrogen peroxide (H2O2) triggers checkpoint kinase 1 (Chk1) phosphorylation in an ATR [ataxia-telangiectasia mutated (ATM) and Rad3-related]-dependent but ATM-independent manner in Xenopus egg extracts. A base excision repair protein, Apurinic/apyrimidinic (AP) endonuclease 2 (APE2, APN2, or APEX2), is required for the generation of replication protein A (RPA)-bound single-stranded DNA, the recruitment of a checkpoint protein complex [ATR, ATR-interacting protein (ATRIP), and Rad9] to damage sites, and H2O2-induced Chk1 phosphorylation. A conserved proliferating cell nuclear antigen interaction protein box of APE2 is important for the recruitment of APE2 to H2O2-damaged chromatin. APE2 3'-phosphodiesterase and 3'-5' exonuclease activity is essential for single-stranded DNA generation in the 3'-5' direction from single-stranded breaks, referred to as single-stranded break end resection. In addition, APE2 associates with Chk1, and a serine residue (S86) in the Chk1-binding motif of APE2 is essential for Chk1 phosphorylation, indicating a Claspin-like but distinct role for APE2 in ATR-Chk1 signaling. Our data indicate that APE2 plays a vital and previously unexpected role in ATR-Chk1 checkpoint signaling in response to oxidative stress. Thus, our findings shed light on a distinct mechanism of how an ATR-Chk1-dependent DNA damage checkpoint is mediated by APE2 in the oxidative stress response.

  15. 10 CFR 830 Major Modification Determination for the ATR Diesel Bus (E-3) and Switchgear Replacement

    Energy Technology Data Exchange (ETDEWEB)

    Noel Duckwtiz

    2011-05-01

    Near term replacement of aging and obsolescent original ATR equipment has become important to ensure ATR capability in support of NE’s long term national missions. To that end, a mission needs statement has been prepared for a non-major system acquisition which is comprised of three interdependent subprojects. The first project, subject of this determination, will replace the existent diesel-electrical bus (E-3) and associated switchgear. More specifically, INL proposes transitioning ATR to 100% commercial power with appropriate emergency backup to include: • Provide commercial power as the normal source of power to the ATR loads currently supplied by diesel-electric power. • Provide backup power to the critical ATR loads in the event of a loss of commercial power. • Replace obsolescent critical ATR power distribution equipment, e.g., switchgear, transformers, motor control centers, distribution panels. Completion of this and two other age-related projects (primary coolant pump and motor replacement and emergency firewater injection system replacement) will resolve major age related operational issues plus make a significant contribution in sustaining the ATR safety and reliability profile. The major modification criteria evaluation of the project pre-conceptual design identified several issues make the project a major modification: 1. Evaluation Criteria #2 (Footprint change). The addition of a new PC-4 structure to the ATR Facility to house safety-related SSCs requires careful attention to maintaining adherence to applicable engineering and nuclear safety design criteria (e.g., structural qualification, fire suppression) to ensure no adverse impacts to the safety-related functions of the housed equipment. 2. Evaluation Criteria #3 (Change of existing process). The change to the strategy for providing continuous reliable power to the safety-related emergency coolant pumps requires careful attention and analysis to ensure it meets a project primary object

  16. PREFACE: The Irago Conference 2012

    Science.gov (United States)

    Sandhu, Adarsh; Okada, Hiroshi

    2013-04-01

    The Irago Conference 2012 - 360 degree outlook on critical scientific and technological challenges for a sustainable society Organized by the Electronics-Inspired Interdisciplinary Research Institute (EIIRIS) at Toyohashi University of Technology, the Irago Conference, held recently (15-16 November) in Aichi, Japan, aimed to enhance mutual understanding between scientists, engineers and policymakers. Over 180 participants tackled topics ranging from energy and natural resources to public health and disaster prevention. The 360-degree outlook of the conference impressed speakers and guests. ''This conference has been extremely informative,'' noted Robert Gellar from the University of Tokyo. ''A unique conference with experts from a range of backgrounds,'' agreed Uracha Ruktanonchai from the National Nanotechnology Center (NANOTEC) in Thailand. Similarly, G P Li, professor of electrical engineering and computer science at the University of California Irvine commented that he had been ''able to think the unthinkable'' as a range of topics came together. The conference was streamed live on Ustream to ensure that researchers from across the world could benefit from thought-provoking presentations examining global issues such as energy, disaster mitigation and nanotechnology. ''This was wonderful,'' said Oussama Khatib from Stanford University, ''A good recipe of speakers from such a range of backgrounds.'' Manuscripts submitted to the organizers were peer-reviewed, and the papers in this proceedings were accepted for Journal of Physics: Conference Series. In addition to the formal speaker programme, graduate-student sessions provided a platform for graduate students to describe their latest findings as oral presentations. A series of excursions to relevant locations, such as the Tahara megasolar region under construction and a local car-manufacturing factory, gave participants the opportunity to further consider practical applications of their research in industry

  17. Alterations in ATR in nasal NK/T-cell lymphoma and chronic active Epstein-Barr virus infection.

    Science.gov (United States)

    Liu, Angen; Takakuwa, Tetsuya; Luo, Wen-Juan; Fujita, Shigeki; Aozasa, Katsuyuki

    2006-07-01

    Nasal natural killer (NK)/T-cell lymphoma (NKTCL) and chronic active Epstein-Barr virus infection (CAEBV) are relatively frequent, especially in Asia, and are poor in prognosis. Both diseases are proliferative diseases of NK/T cells that show highly complicated karyotypes, suggesting the involvement of chromosomal instability. ATR is an important gene for DNA damage response and chromosomal stability. To evaluate the role of ATR gene alterations in the pathogenesis of NKTCL and CAEBV, the whole coding region of the ATR gene was examined in cell lines derived from NKTCL and CAEBV, as well as tumor samples from patients. ATR alterations were detected in two of eight NKTCL and in one of three CAEBV lines. Most aberrant transcripts observed were deletions resulting from aberrant splicing. ATR alterations were also detected in four of 10 NKTCL clinical samples. Both NKTCL and CAEBV cell lines with ATR alterations showed a delay or abrogation in repair of ionizing radiation-induced DNA double-strand breaks and ultraviolet-induced DNA single-strand breaks, and both exhibited a defect in p53 accumulation. These findings show that alterations in the ATR gene result in an abnormal response to DNA double-strand break and single-strand break repair, suggesting a role for ATR gene alterations in NKTCL lymphomagenesis.

  18. Small-molecule inhibitors of Ataxia Telangiectasia and Rad3 related kinase (ATR) sensitize lymphoma cells to UVA radiation

    DEFF Research Database (Denmark)

    Biskup, Edyta; Naym, David Gram; Gniadecki, Robert

    2016-01-01

    and require more aggressive therapies. OBJECTIVE: The aim of this project was to investigate whether inhibition of Ataxia Telangiectasia and Rad3 related kinase (ATR) may enhance efficacy of phototherapy. METHODS: CTCL cell lines (MyLa2000, SeAx and Mac2a) served as in vitro cell models. ATR and Chk1 were...

  19. ATR-FTIR Spectroscopy in the Undergraduate Chemistry Laboratory: Part II--A Physical Chemistry Laboratory Experiment on Surface Adsorption

    Science.gov (United States)

    Schuttlefield, Jennifer D.; Larsen, Sarah C.; Grassian, Vicki H.

    2008-01-01

    Attenuated total reflectance-Fourier transform infrared (ATR-FTIR) spectroscopy is a useful technique for measuring the infrared spectra of solids and liquids as well as probing adsorption on particle surfaces. The use of FTIR-ATR spectroscopy in organic and inorganic chemistry laboratory courses as well as in undergraduate research was presented…

  20. Organising, Educating... Changing the World

    Science.gov (United States)

    Grayson, John

    2005-01-01

    Over the past few years a constellation of social movements and organisations concerned with issues of globalisation and world poverty have exploded onto the world stage. They have mobilised demonstrations, organised mass gatherings and conferences, created e-networks and websites and become major players in international political lobbying and…

  1. 78 FR 12136 - Preparations for the International Telecommunication Union World Telecommunication Development...

    Science.gov (United States)

    2013-02-21

    ... Preparations for the International Telecommunication Union World Telecommunication Development Conference (ITU... International Telecommunication Advisory Committee (ITAC) to begin preparations for the ITU World Telecommunication Development Conference (WTDC 2014). The meetings are announced to the ITAC committee and referred...

  2. ATR controls cellular adaptation to hypoxia through positive regulation of hypoxia-inducible factor 1 (HIF-1) expression.

    Science.gov (United States)

    Fallone, F; Britton, S; Nieto, L; Salles, B; Muller, C

    2013-09-12

    Tumor cells adaptation to severe oxygen deprivation (hypoxia) plays a major role in tumor progression. The transcription factor HIF-1 (hypoxia-inducible factor 1), whose α-subunit is stabilized under hypoxic conditions is a key component of this process. Recent studies showed that two members of the phosphoinositide 3-kinase-related kinases (PIKKs) family, ATM (ataxia telangiectasia mutated) and DNA-PK (DNA-dependent protein kinase), regulate the hypoxic-dependent accumulation of HIF-1. These proteins initiate cellular stress responses when DNA damage occurs. In addition, it has been demonstrated that extreme hypoxia induces a replicative stress resulting in regions of single-stranded DNA at stalled replication forks and the activation of ATR (ataxia telangiectasia and Rad3 related protein), another member of the PIKKs family. Here, we show that even less severe hypoxia (0.1% O2) also induces activation of ATR through replicative stress. Importantly, in using either transiently silenced ATR cells, cells expressing an inactive form of ATR or cells exposed to an ATR inhibitor (CGK733), we demonstrate that hypoxic ATR activation positively regulates the key transcription factor HIF-1 independently of the checkpoint kinase Chk1. We show that ATR kinase activity regulates HIF-1α at the translational level and we find that the elements necessary for the regulation of HIF-1α translation are located within the coding region of HIF-1α mRNA. Finally, by using three independent cellular models, we clearly show that the loss of ATR expression and/or kinase activity results in the decrease of HIF-1 DNA binding under hypoxia and consequently affects protein expression levels of two HIF-1 target genes, GLUT-1 and CAIX. Taken together, our data show a new function for ATR in cellular adaptation to hypoxia through regulation of HIF-1α translation. Our work offers new prospect for cancer therapy using ATR inhibitors with the potential to decrease cellular adaptation in hypoxic

  3. La segunda conferencia mundial de educación superior (unesco, 2009 y la visión del concepto de acreditación en las conferencias de unesco (1998-2009 The second world conference of higher education (unesco, 2009 and the vision of accreditation in the conferences of unesco (1998-2009

    Directory of Open Access Journals (Sweden)

    Francisco López Segrera

    2012-11-01

    Full Text Available El presente artículo formula algunas reflexiones sobre la Segunda Conferencia Mundial de Educación Superior (UNESCO, 2009. El debate principal en ella versó sobre la visión de enseñanza superior como "un bien común", o como "un servicio público", esta última visión fue considerada por muchos delegados como un camino hacia una mayor mercantilización. En el Comunicado Final prevaleció el primer criterio. También en el artículo se analizan los cambios principales en los conceptos de evaluación, calidad, garantía de la calidad y acreditación entre 1995 y 2009. El énfasis se ha movido de la evaluación y la calidad (1995-1998 a la garantía de calidad y acreditación (1998-2003 y luego (2008-2009 en vincular los criterios de calidad a la pertinencia.The present article formulates some reflections on The Second World Higher Education Conference (UNESCO, 2009. The main debate was about the vision of higher education as "a common good", or as "a public service", this last vision was considered by many delegates as a road to further mercantilization. In the Final Communiqué the first criterion prevailed. The article also analyzes the main changes concerning the concepts of evaluation, quality, quality assurance and accreditation between 1995 and 2009. The emphasis has moved from evaluation and quality (1995-1998 to quality assurance and accreditation (1998-2003 and then (2008-2009 in linking the quality criteria to pertinence, relevance, equity, and sustainable development.

  4. Cyclohexene photo-oxidation over vanadia catalyst analyzed by time resolvedATR-FT-IT spectroscopy

    NARCIS (Netherlands)

    Mul, Guido; Wasylenko, W.; Sameh Hamdy, M.; Frei, H.

    2008-01-01

    Vanadia was incorporated in the 3-D mesoporous material TUD-1 with a loading of 2% w/w vanadia. The performance in the selective photo-oxidation of liquid cyclohexene was investigated using ATR-FT-IR spectroscopy. Under continuous illumination at 458 nm a significant amount of product,

  5. ATM/ATR-mediated phosphorylation of PALB2 promotes RAD51 function

    DEFF Research Database (Denmark)

    Ahlskog, Johanna K; Larsen, Brian D; Achanta, Kavya

    2016-01-01

    DNA damage activates the ATM and ATR kinases that coordinate checkpoint and DNA repair pathways. An essential step in homology-directed repair (HDR) of DNA breaks is the formation of RAD51 nucleofilaments mediated by PALB2-BRCA2; however, roles of ATM and ATR in this critical step of HDR are poorly...... understood. Here, we show that PALB2 is markedly phosphorylated in response to genotoxic stresses such as ionizing radiation and hydroxyurea. This response is mediated by the ATM and ATR kinases through three N-terminal S/Q-sites in PALB2, the consensus target sites for ATM and ATR Importantly, a phospho......-deficient PALB2 mutant is unable to support proper RAD51 foci formation, a key PALB2 regulated repair event, whereas a phospho-mimicking PALB2 version supports RAD51 foci formation. Moreover, phospho-deficient PALB2 is less potent in HDR than wild-type PALB2. Further, this mutation reveals a separation in PALB2...

  6. Hydroxyl accessibility in wood by deuterium exchange and ATR-FTIR spectroscopy

    DEFF Research Database (Denmark)

    Tarmian, Asghar; Burgert, Ingo; Thybring, Emil Engelund

    2017-01-01

    The accessibility of wood hydroxyls to water is commonly studied by infrared spectroscopy after deuteration where water-interacting hydroxyls have their H exchanged for D. In this study, the hydroxyl accessibility is determined with ATR-FTIR spectroscopy after deuteration of specimens with liquid D...

  7. 78 FR 42898 - Airworthiness Directives; ATR-GIE Avions de Transport Régional Airplanes

    Science.gov (United States)

    2013-07-18

    ... investigation into an ATR 72 accident in August 2005 have shown that overruling standard operational procedures... proposed AD was prompted by reports of airplane incidents and accidents that have occurred because of low.... ADDRESSES: You may send comments by any of the following methods: Federal eRulemaking Portal: Go to http...

  8. Dynamic generation of artificial HRSAR imagery for ATR development and cockpit simulation

    Science.gov (United States)

    Seidel, Heiko; Stahl, Christoph; Knappe, Peter; Hurst, Peter

    2004-09-01

    Following the tendency of increasingly using imaging sensors in military aircraft, future combat airplane pilots will need onboard artificial intelligence for aiding them in image interpretation and target designation. This document presents a system which is able to simulate high-resolution artificial SAR imagery and thereby facilitates automatic target recognition (ATR) algorithm development. The system provides a comprehensive interface that allows dynamically requesting imagery depending on the location and heading of a simulated carrier platform. Landscapes, structures and target signatures are generated based on digital terrain data and target models. An assessment of dissimilar database preparations for sensor simulation was done with respect to the different properties of SAR imaging compared to optical imaging. The document presents selected results for specific landscape elements. Post-processing algorithms for overcoming weaknesses of digital terrain databases and improving image realism are presented. Simulated sensor imagery is useful in a wide range of applications, two of which are training of ATR algorithms and sensor simulation in flight simulation environments. Using an existing ATR method as an example, the applicability and the influences of synthetic imagery on ATR training are shown and first approaches on how to validate the correctness of the imagery are explained. The integration of the system into a flight simulator in the context of interfacing and control topics serves as a concluding example.

  9. An in situ ATR-IR spectroscopy study of aluminas under aqueous phase reforming conditions

    NARCIS (Netherlands)

    Koichumanova, Kamila; Gupta, K.B. Sai Sankar; Lefferts, Leonardus; Mojet, Barbara; Seshan, Kulathuiyer

    2015-01-01

    High temperature/pressure in situ Attenuated Total Reflection Infrared (ATR-IR) spectroscopy was used to investigate the phase transformation of support γ-Al2O3 into boehmite (AlO(OH)) under the hydrothermal conditions of aqueous phase reforming (APR). Activation energy barriers of boehmite

  10. Increased Rrm2 gene dosage reduces fragile site breakage and prolongs survival of ATR mutant mice

    DEFF Research Database (Denmark)

    Lopez-Contreras, Andres J; Specks, Julia; Barlow, Jacqueline H

    2015-01-01

    of the RNR regulatory subunit RRM2 (Rrm2(TG)) present supraphysiological RNR activity and reduced chromosomal breakage at fragile sites. Moreover, increased Rrm2 gene dosage significantly extends the life span of ATR mutant mice. Our study reveals the first genetic condition in mammals that reduces fragile...

  11. Roles of ATR1 paralogs YMR279c and YOR378w in boron stress tolerance.

    Science.gov (United States)

    Bozdag, Gonensin Ozan; Uluisik, Irem; Gulculer, Gulce Sila; Karakaya, Huseyin C; Koc, Ahmet

    2011-06-17

    Boron is a necessary nutrient for plants and animals, however excess of it causes toxicity. Previously, Atr1 and Arabidopsis Bor1 homolog were identified as the boron efflux pump in yeast, which lower the cytosolic boron concentration and help cells to survive in the presence of toxic amount of boron. In this study, we analyzed ATR1 paralogs, YMR279c and YOR378w, to understand whether they participate in boron stress tolerance in yeast. Even though these genes share homology with ATR1, neither their deletion rendered cells boron sensitive nor their expression was significantly upregulated by boron treatment. However, expression of YMR279, but not YOR378w, from the constitutive GAPDH promoter on a high copy plasmid provided remarkable boron resistance by decreasing intracellular boron levels. Thus our results suggest the presence of a third boron exporter, YMR279c, which functions similar to ATR1 and provides boron resistance in yeast. Copyright © 2011 Elsevier Inc. All rights reserved.

  12. 76 FR 70044 - Airworthiness Directives; ATR-GIE Avions de Transport Régional Airplanes

    Science.gov (United States)

    2011-11-10

    ... require parts costing $960, for a cost of $6,060 per product. We have no way of determining the number of... condition on an aviation product. The MCAI describes the unsafe condition as: One ATR operator has... condition on these products. DATES: This AD becomes effective December 15, 2011. The Director of the Federal...

  13. Measured thermal and fast neutron fluence rates for ATF-1 holders during ATR cycle 160A

    Energy Technology Data Exchange (ETDEWEB)

    Walker, B. J. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Miller, D. T. [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2017-06-06

    This report contains the thermal (2200 m/s) and fast (E>1MeV) neutron fluence rate data for the ATF-1 holders located in core for ATR Cycle 160A which were measured by the Radiation Measurements Laboratory (RML).

  14. An add-on system including a micro-reactor for an atr-ir spectrometer

    DEFF Research Database (Denmark)

    2014-01-01

    The invention relates to an add-on system for an attenuated total reflectance infrared (ATR-IR) spectrometer, the add-on system allowing for time-resolved in situ IR measurements of heterogeneous mixtures. The add-on device comprises a micro-reactor (300A) forming a sample cavity (305) when...

  15. An add-on system for photochemical ATR-IR spectroscopy studies

    DEFF Research Database (Denmark)

    2014-01-01

    The invention relates to an add-on system for a unit mainly adapted for attenuated total reflectance infrared (ATR-IR) spectroscopy. The add-on system enables time-resolved in-situ measurements of different sample types in an easy, simple and inexpensive way. The add-on system includes a cap (300G...

  16. DNA-PKcs, ATM, and ATR Interplay Maintains Genome Integrity during Neurogenesis.

    Science.gov (United States)

    Enriquez-Rios, Vanessa; Dumitrache, Lavinia C; Downing, Susanna M; Li, Yang; Brown, Eric J; Russell, Helen R; McKinnon, Peter J

    2017-01-25

    The DNA damage response (DDR) orchestrates a network of cellular processes that integrates cell-cycle control and DNA repair or apoptosis, which serves to maintain genome stability. DNA-PKcs (the catalytic subunit of the DNA-dependent kinase, encoded by PRKDC), ATM (ataxia telangiectasia, mutated), and ATR (ATM and Rad3-related) are related PI3K-like protein kinases and central regulators of the DDR. Defects in these kinases have been linked to neurodegenerative or neurodevelopmental syndromes. In all cases, the key neuroprotective function of these kinases is uncertain. It also remains unclear how interactions between the three DNA damage-responsive kinases coordinate genome stability, particularly in a physiological context. Here, we used a genetic approach to identify the neural function of DNA-PKcs and the interplay between ATM and ATR during neurogenesis. We found that DNA-PKcs loss in the mouse sensitized neuronal progenitors to apoptosis after ionizing radiation because of excessive DNA damage. DNA-PKcs was also required to prevent endogenous DNA damage accumulation throughout the adult brain. In contrast, ATR coordinated the DDR during neurogenesis to direct apoptosis in cycling neural progenitors, whereas ATM regulated apoptosis in both proliferative and noncycling cells. We also found that ATR controls a DNA damage-induced G2/M checkpoint in cortical progenitors, independent of ATM and DNA-PKcs. These nonoverlapping roles were further confirmed via sustained murine embryonic or cortical development after all three kinases were simultaneously inactivated. Thus, our results illustrate how DNA-PKcs, ATM, and ATR have unique and essential roles during the DDR, collectively ensuring comprehensive genome maintenance in the nervous system. The DNA damage response (DDR) is essential for prevention of a broad spectrum of different human neurologic diseases. However, a detailed understanding of the DDR at a physiological level is lacking. In contrast to many in

  17. 2nd Tourism Postdisciplinarity Conference

    DEFF Research Database (Denmark)

    Following the noted success of the 1st international conference on postdisciplinary approaches to tourism studies (held in Neuchatel, Switzerland, 19-22 June, 2013), we are happy to welcome you to the 2nd Tourism Postdisciplinarity Conference. Postdisciplinarity surpasses the boundaries...... of study less embedded in that system of thought. Postdisciplinarity is an epistemological endeavour that speaks of knowledge production and the ways in which the world of physical and social phenomena can be known. It is also an ontological discourse as it concerns what we call ‘tourism...

  18. Protein phosphatase 5 is necessary for ATR-mediated DNA repair

    Energy Technology Data Exchange (ETDEWEB)

    Kang, Yoonsung [Department of Pharmacology, DNA Repair Research Center, Chosun University School of Medicine, 375 Seosuk-Dong, Gwangju 501-759 (Korea, Republic of); Cheong, Hyang-Min [Department of Life Science, College of Natural Science, Chung-Ang University, 221 Heuksuk-Dong, Dongjak-Ku, Seoul 156-756 (Korea, Republic of); Lee, Jung-Hee [Department of Pharmacology, DNA Repair Research Center, Chosun University School of Medicine, 375 Seosuk-Dong, Gwangju 501-759 (Korea, Republic of); Song, Peter I. [Department of Dermatology, University of Arkansas for Medical Science, 4301 West Markham, Slot 576, Little Rock, AR 72205 (Korea, Republic of); Lee, Kwang-Ho [Department of Life Science, College of Natural Science, Chung-Ang University, 221 Heuksuk-Dong, Dongjak-Ku, Seoul 156-756 (Korea, Republic of); Kim, Sang-Yong [Division of Endocrinology, Department of Internal Medicine, Chosun University School of Medicine, 375 Seosuk-Dong, Gwangju 501-759 (Korea, Republic of); Jun, Jae Yeoul [Department of Physiology, Chosun University School of Medicine, 375 Seosuk-Dong, Gwangju 501-759 (Korea, Republic of); You, Ho Jin, E-mail: hjyou@chosun.ac.kr [Department of Pharmacology, DNA Repair Research Center, Chosun University School of Medicine, 375 Seosuk-Dong, Gwangju 501-759 (Korea, Republic of)

    2011-01-07

    Research highlights: {yields} Serine/threonine protein phosphatase 5 (PP5) has been shown to participate in ataxia telangiectasia-mutated (ATM)- and ATR (ATM- and Rad3-related)-mediated checkpoint pathways, which plays an important role in the DNA damage response and maintenance of genomic stability. {yields} However, it is not clear exactly how PP5 participates in this process. {yields} Our results indicate that PP5 is more closely related with ATR-mediated pathway than ATM-mediated pathway in DNA damage repair. -- Abstract: Several recent studies have shown that protein phosphatase 5 (PP5) participates in cell cycle arrest after DNA damage, but its roles in DNA repair have not yet been fully characterized. We investigated the roles of PP5 in the repair of ultraviolet (UV)- and neocarzinostatin (NCS)-induced DNA damage. The results of comet assays revealed different repair patterns in UV- and NCS-exposed U2OS-PS cells. PP5 is only essential for Rad3-related (ATR)-mediated DNA repair. Furthermore, the phosphorylation of 53BP1 and BRCA1, important mediators of DNA damage repair, and substrates of ATR and ATM decreased in U2OS-PS cells exposed to UV radiation. In contrast, the cell cycle arrest proteins p53, CHK1, and CHK2 were normally phosphorylated in U2OS and U2OS-PS cells exposed to UV radiation or treated with NCS. In view of these results, we suggest that PP5 plays a crucial role in ATR-mediated repair of UV-induced DNA damage.

  19. Estimation of the age of human bloodstains under the simulated indoor and outdoor crime scene conditions by ATR-FTIR spectroscopy.

    Science.gov (United States)

    Lin, Hancheng; Zhang, Yinming; Wang, Qi; Li, Bing; Huang, Ping; Wang, Zhenyuan

    2017-10-16

    Estimation of the age of human bloodstains is of great importance in forensic practices, but it is a challenging task because of the lack of a well-accepted, reliable, and established method. Here, the attenuated total reflection (ATR)-Fourier transform infrared (FTIR) technique combined with advanced chemometric methods was utilized to determine the age of indoor and outdoor bloodstains up to 107 days. The bloodstain storage conditions mimicked crime scene scenarios as closely as possible. Two partial least squares regression models-indoor and outdoor models with 7-85 days-exhibited good performance for external validation, with low values of predictive root mean squared error (5.83 and 4.77) and high R(2) values (0.94 and 0.96) and residual predictive deviation (4.08 and 5.14), respectively. Two partial least squares-discriminant analysis classification models were built and demonstrated excellent distinction between fresh (age ≤1 d) and older (age >1 d) bloodstains, which is highly valuable for forensic investigations. These findings demonstrate that ATR-FTIR spectroscopy coupled with advanced chemometric methods can be employed as a rapid and non-destructive tool for age estimation of bloodstains in real-world forensic investigation.

  20. EGC Conferences

    CERN Document Server

    Ritschard, Gilbert; Pinaud, Bruno; Venturini, Gilles; Zighed, Djamel; Advances in Knowledge Discovery and Management

    This book is a collection of representative and novel works done in Data Mining, Knowledge Discovery, Clustering and Classification that were originally presented in French at the EGC'2012 Conference held in Bordeaux, France, on January 2012. This conference was the 12th edition of this event, which takes place each year and which is now successful and well-known in the French-speaking community. This community was structured in 2003 by the foundation of the French-speaking EGC society (EGC in French stands for ``Extraction et Gestion des Connaissances'' and means ``Knowledge Discovery and Management'', or KDM). This book is intended to be read by all researchers interested in these fields, including PhD or MSc students, and researchers from public or private laboratories. It concerns both theoretical and practical aspects of KDM. The book is structured in two parts called ``Knowledge Discovery and Data Mining'' and ``Classification and Feature Extraction or Selection''. The first part (6 chapters) deals with...

  1. NATO Conference

    CERN Document Server

    Lynn, W

    1975-01-01

    The contents of this volume involve selection, emendation and up-dating of papers presented at the NATO Conference "Mathe­ matical Analysis of Decision problems in Ecology" in Istanbul, Turkey, July 9-13, 1973. It was sponsored by the System Sciences Division of NATO directed by Dr. B. Bayraktar with local arrange­ ments administered by Dr. Ilhami Karayalcin, professor of the Department of Industrial Engineering at the Technical University of Istanbul. It was organized by A. Charnes, University professor across the University of Texas System, and Walter R.Lynn, Di­ rector of the School of Civil and Environmental Engineering at Cornell Unjversity. The objective of the conference was to bring together a group of leading researchers from the major sciences involved in eco­ logical problems and to present the current state of progress in research of a mathematical nature which might assist in the solu­ tion of these problems. Although their presentations are not herein recorded, the key­ note address of Dr....

  2. News Education: Physics Education Networks meeting has global scale Competition: Competition seeks the next Brian Cox Experiment: New measurement of neutrino time-of-flight consistent with the speed of light Event: A day for all those who teach physics Conference: Students attend first Anglo-Japanese international science conference Celebration: Will 2015 be the 'Year of Light'? Teachers: Challenging our intuition in spectacular fashion: the fascinating world of quantum physics awaits Research: Science sharpens up sport Learning: Kittinger and Baumgartner: on a mission to the edge of space International: London International Youth Science Forum calls for leading young scientists Competition: Physics paralympian challenge needs inquisitive, analytical, artistic and eloquent pupils Forthcoming events

    Science.gov (United States)

    2012-05-01

    Education: Physics Education Networks meeting has global scale Competition: Competition seeks the next Brian Cox Experiment: New measurement of neutrino time-of-flight consistent with the speed of light Event: A day for all those who teach physics Conference: Students attend first Anglo-Japanese international science conference Celebration: Will 2015 be the 'Year of Light'? Teachers: Challenging our intuition in spectacular fashion: the fascinating world of quantum physics awaits Research: Science sharpens up sport Learning: Kittinger and Baumgartner: on a mission to the edge of space International: London International Youth Science Forum calls for leading young scientists Competition: Physics paralympian challenge needs inquisitive, analytical, artistic and eloquent pupils Forthcoming events

  3. Knockdown of REV3 synergizes with ATR inhibition to promote apoptosis induced by cisplatin in lung cancer cells.

    Science.gov (United States)

    Jiang, He-Guo; Chen, Ping; Su, Jin-Yu; Wu, Ming; Qian, Hai; Wang, Yi; Li, Jian

    2017-12-01

    It has been demonstrated that REV3, the catalytic subunit of the translesion synthesis (TLS) polymerase ζ, play an important role in DNA damage response (DDR) induced by cisplatin, and Ataxia-telangietasia mutated and Rad-3-related (ATR) knase is a central player in activating cell cycle checkpoint, stabilizing replication forks, regulating DDR, and promoting repair of DNA damage caused by cisplatin. Cancer cells deficient in either one of REV3 and ATR are more sensitive to cisplatin. However, whether co-inhibition of REV3 and ATR can further increase sensitivity of non-small cell lung cancer (NSCLC) cells to cisplatin is not clear. In this study, we show that REV3 knockdown combined with ATR inhibition further enhance cytotoxicity of cisplatin in NSCLC cells, including cisplatin-sensitive and -resistant cell lines, compared to individual knockdown of REV3 or ATR, which are accompanied by markedly caspase-dependent apoptosis response, pronounced DNA damage accumulation and severe impediment of interstrand crosslink (ICL), and double strand break (DSB) repair. Our results suggest that REV3 knockdown synergize strongly with ATR inhibition to significantly increase sensitivity of cisplatin in NSCLC cells by inhibiting ICL and DSB repair. Thus simultaneously targeting REV3 and ATR may represent one approach to overcome cisplatin resistance and improve chemotherapeutic efficacy in NSCLC treatment. © 2017 Wiley Periodicals, Inc.

  4. Fifth International Conference KSE 2013

    CERN Document Server

    Denoeux, Thierry; Tran, Dang; Le, Anh; Pham, Son; Knowledge and Systems Engineering

    2014-01-01

    The field of Knowledge and Systems Engineering (KSE) has experienced rapid development and inspired many applications in the world of information technology during the last decade. The KSE conference aims at providing an open international forum for presentation, discussion and exchange of the latest advances and challenges in research of the field. These proceedings contain papers presented at the Fifth International Conference on Knowledge and Systems Engineering (KSE 2013), which was held in Hanoi, Vietnam, during 17–19 October, 2013. Besides the main track of contributed papers, which are compiled into the first volume, the conference also featured several special sessions focusing on specific topics of interest as well as included one workshop, of which the papers form the second volume of these proceedings. The book gathers a total of 68 papers describing recent advances and development on various topics including knowledge discovery and data mining, natural language processing, expert systems, intell...

  5. World Literature - World Culture

    DEFF Research Database (Denmark)

    Offering their own twenty-first-century perspectives - across generations, nationalities and disciplines -, the contributors to this anthology explore the idea of world literature for what it may add of new connections and itineraries to the study of literature and culture today. Covering a vast ...

  6. PREFACE: Quark Matter 2006 Conference Quark Matter 2006 Conference

    Science.gov (United States)

    Ma, Yu-Gang; Wang, En-Ke; Cai, Xu; Huang, Huan-Zhong; Wang, Xin-Nian; Zhu, Zhi-Yuan

    2007-07-01

    The Quark Matter 2006 conference was held on 14-20 November 2006 at the Shanghai Science Hall of the Shanghai Association of Sciences and Technology in Shanghai, China. It was the 19th International Conference on Ultra-Relativistic Nucleus-Nucleus Collisions. The conference was organized jointly by SINAP (Shanghai Institute of Applied Physics, Chinese Academy of Sciences (CAS)) and CCNU (Central China Normal University, Wuhan). Over 600 scientists from 32 countries in five continents attended the conference. This is the first time that China has hosted such a premier conference in the field of relativistic heavy-ion collisions, an important event for the Chinese high energy nuclear physics community. About one half of the conference participants are junior scientists—a clear indication of the vigor and momentum for this field, in search of the fundamental nature of the nuclear matter at extreme conditions. Professor T D Lee, honorary chair of the conference and one of the founders of the quark matter research, delivered an opening address with his profound and philosophical remarks on the recent discovery of the nature of strongly-interacting quark-gluon-plasma (sQGP). Professor Hongjie Xu, director of SINAP, gave a welcome address to all participants on behalf of the two hosting institutions. Dr Peiwen Ji, deputy director of the Mathematics and Physics Division of the Natural Science Foundation of China (NSFC), also addressed the conference participants and congratulated them on the opening of the conference. Professor Mianheng Jiang, vice president of the Chinese Academy of Sciences (CAS), gave a concise introduction about the CAS as the premier research institution in China. He highlighted continued efforts at CAS to foster international collaborations between China and other nations. The Quark Matter 2006 conference is an example of such a successful collaboration between high energy nuclear physicists in China and other nations all over the world. The

  7. Advanced Test Reactor National Scientific User Facility (ATR NSUF) Monthly Report November 2014

    Energy Technology Data Exchange (ETDEWEB)

    Soelberg, Renae [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2014-11-01

    Advanced Test Reactor National Scientific User Facility (ATR NSUF) Monthly Report November 2014 Highlights Rory Kennedy and Sarah Robertson attended the American Nuclear Society Winter Meeting and Nuclear Technology Expo in Anaheim, California, Nov. 10-13. ATR NSUF exhibited at the technology expo where hundreds of meeting participants had an opportunity to learn more about ATR NSUF. Dr. Kennedy briefed the Nuclear Engineering Department Heads Organization (NEDHO) on the workings of the ATR NSUF. • Rory Kennedy, James Cole and Dan Ogden participated in a reactor instrumentation discussion with Jean-Francois Villard and Christopher Destouches of CEA and several members of the INL staff. • ATR NSUF received approval from the NE-20 office to start planning the annual Users Meeting. The meeting will be held at INL, June 22-25. • Mike Worley, director of the Office of Innovative Nuclear Research (NE-42), visited INL Nov. 4-5. Milestones Completed • Recommendations for the Summer Rapid Turnaround Experiment awards were submitted to DOE-HQ Nov. 12 (Level 2 milestone due Nov. 30). Major Accomplishments/Activities • The University of California, Santa Barbara 2 experiment was unloaded from the GE-2000 at HFEF. The experiment specimen packs will be removed and shipped to ORNL for PIE. • The Terrani experiment, one of three FY 2014 new awards, was completed utilizing the Advanced Photon Source MRCAT beamline. The experiment investigated the chemical state of Ag and Pd in SiC shell of irradiated TRISO particles via X-ray Absorption Fine Structure (XAFS) spectroscopy. Upcoming Meetings/Events • The ATR NSUF program review meeting will be held Dec. 9-10 at L’Enfant Plaza. In addition to NSUF staff and users, NE-4, NE-5 and NE-7 representatives will attend the meeting. Awarded Research Projects Boise State University Rapid Turnaround Experiments (14-485 and 14-486) Nanoindentation and TEM work on the T91, HT9, HCM12A and 9Cr ODS specimens has been completed at

  8. MUSME Conference

    CERN Document Server

    Martinez, Eusebio

    2015-01-01

    This volume contains the Proceedings of MUSME 2014, held at Huatulco in Oaxaca, Mexico, October 2014. Topics include analysis and synthesis of mechanisms; dynamics of multibody systems; design algorithms for mechatronic systems; simulation procedures and results; prototypes and their performance; robots and micromachines; experimental validations; theory of mechatronic simulation; mechatronic systems; and control of mechatronic systems. The MUSME symposium on Multibody Systems and Mechatronics was held under the auspices of IFToMM, the International Federation for Promotion of Mechanism and Machine Science, and FeIbIM, the Iberoamerican Federation of Mechanical Engineering. Since the first symposium in 2002, MUSME events have been characterised by the way they stimulate the integration between the various mechatronics and multibody systems dynamics disciplines, present a forum for facilitating contacts among researchers and students mainly in South American countries, and serve as a joint conference for the ...

  9. Conference proceedings

    African Journals Online (AJOL)

    ebutamanya

    2016-02-29

    Feb 29, 2016 ... United Nations' agencies (World Health Organization, United Nations. Children's Fund); international organisations(Malaria Vaccine. Initiative, PATH, International AIDS Vaccine Initiative, Agence de. Medecine Preventive, Bill and Melinda Gates Foundation); private- public partnerships (Global Alliance for ...

  10. Conference Attendees’ Satisfaction: Evidence from Belgrade (Serbia

    Directory of Open Access Journals (Sweden)

    Dunjić Jelena

    2012-10-01

    Full Text Available Conference industry brings significant economic effects and that is one of the reasons why many destinations around the world strive to organize conferences, especially the international ones, which make bigger economic effects. According to the Strategy of tourism development of the Republic of Serbia (2005-2015, city break and business tourism are tourism products of high priority, which can provide short-term positioning of Novi Sad and Belgrade, at the first place, at the international tourism market, and contribute to the growth of tourism turnover of foreign travellers.Belgrade is the capital and the largest city in Serbia. It is very well equipped with necessary infrastructure for organizing business events such as conferences, congresses, meetings etc. Lately, the number of international business events in Serbia is increasing and the majority of those events are organized in Belgrade. However, there are very few surveys which are examining satisfaction of the conference attendees in Serbia. This topic is often ignored despite the fact that the attendees satisfaction is substantial for organizers and all other relevant stakeholders at host destination. Therefore, the aim of this paper is to analyze the satisfaction of the conference attendees, as they are final consumers of conference tourist product and their experience regarding both conference and host destination is thus essential to destination marketing and management organizations, conference centres, hotel managers, meeting planners and all other stakeholders involved in conference industry and tourism

  11. Eighth national passive solar conference. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Owen, A.; Zee, R.

    1983-12-01

    The Eighth National Passive Solar Conference was held near Santa Fe, New Mexico at the Glorieta Conference Center on September 5 to 11, 1983. Nearly 900 people from all across the nation and the world attended the conference. Close to 200 technical papers were presented, 50 solar product exhibits were available; 34 poster sessions were presented; 16 solar workshops were conducted; 10 renowned solar individuals participated in rendezvous sessions; 7 major addresses were delivered; 5 solar home tours were conducted; 2 emerging architecture sessions were held which included 21 separate presentations; and commercial product presentations were given for the first time ever at a national passive solar conference. Peter van Dresser of Santa Fe received the prestigious Passive Solar Pioneer Award, posthumously, from the American Solar Energy Society and Benjamin T. Buck Rogers of Embudo received the prestigious Peter van Dresser Award from the New Mexico Solar Energy Association. This report reviews conference organization, attendance, finances, conference evaluation form results, and includes press coverage samples, selected conference photos courtesy of Marshall Tyler, and a summary with recommendations for future conferences. The Appendices included conference press releases and a report by the New Mexico Solar Industry Development Corporation on exhibits management.

  12. PREFACE: Quark Matter 2006 Conference

    Science.gov (United States)

    Ma, Yu-Gang; Wang, En-Ke; Cai, Xu; Huang, Huan-Zhong; Wang, Xin-Nian; Zhu, Zhi-Yuan

    2007-07-01

    The Quark Matter 2006 conference was held on 14 20 November 2006 at the Shanghai Science Hall of the Shanghai Association of Sciences and Technology in Shanghai, China. It was the 19th International Conference on Ultra-Relativistic Nucleus Nucleus Collisions. The conference was organized jointly by SINAP (Shanghai Institute of Applied Physics, Chinese Academy of Sciences (CAS)) and CCNU (Central China Normal University, Wuhan). Over 600 scientists from 32 countries in five continents attended the conference. This is the first time that China has hosted such a premier conference in the field of relativistic heavy-ion collisions, an important event for the Chinese high energy nuclear physics community. About one half of the conference participants are junior scientists—a clear indication of the vigor and momentum for this field, in search of the fundamental nature of the nuclear matter at extreme conditions. Professor T D Lee, honorary chair of the conference and one of the founders of the quark matter research, delivered an opening address with his profound and philosophical remarks on the recent discovery of the nature of strongly-interacting quark-gluon-plasma (sQGP). Professor Hongjie Xu, director of SINAP, gave a welcome address to all participants on behalf of the two hosting institutions. Dr Peiwen Ji, deputy director of the Mathematics and Physics Division of the Natural Science Foundation of China (NSFC), also addressed the conference participants and congratulated them on the opening of the conference. Professor Mianheng Jiang, vice president of the Chinese Academy of Sciences (CAS), gave a concise introduction about the CAS as the premier research institution in China. He highlighted continued efforts at CAS to foster international collaborations between China and other nations. The Quark Matter 2006 conference is an example of such a successful collaboration between high energy nuclear physicists in China and other nations all over the world. The

  13. Merging science and management in a rapidly changing world: Biodiversity and management of the Madrean Archipelago III and 7th Conference on Research and Resource Management in the Southwestern Deserts; 2012 May 1-5; Tucson, AZ

    Science.gov (United States)

    Gerald J. Gottfried; Peter F. Ffolliott; Brooke S. Gebow; Lane G. Eskew; Loa C. Collins

    2013-01-01

    The Madrean Archipelago or Sky Islands region of the southwestern United States and northern Mexico is recognized for its unique biological diversity, natural beauty, and cultural heritage. This 2012 conference brought together scientists, managers, students, and other interested parties from the United States and Mexico to share their knowledge and passion about the...

  14. Educational Multimedia/Hypermedia and Telecommunications, 1997. Proceedings of ED-MEDIA/ED-TELECOM 97--World Conference on Educational Multimedia/Hypermedia and Educational Telecommunications (Calgary, Canada, June 14-19, 1997). Volumes I and II.

    Science.gov (United States)

    Muldner, Tomasz, Ed.; Reeves, Thomas C., Ed.

    This collection presents papers pertaining to the wide area of educational multimedia/hypermedia and telecommunications. The conference serves as a forum for the dissemination of information on the research, development, and applications in all areas of multimedia/hypermedia and telecommunications in education across all disciplines and levels.…

  15. Meteorological Conditions Associated with the ATR72 Aircraft Accident near Roselawn, Indiana, on 31 October 1994.

    Science.gov (United States)

    Marwitz, J.; Politovich, M.; Bernstein, B.; Ralph, F.; Neiman, P.; Ashenden, R.; Bresch, J.

    1997-01-01

    An ATR72 commuter aircraft crashed near Roselawn, Indiana, on 31 October 1994 killing all 68 people on board. Available weather data, including those from a Next Generation Radar, a radar wind profiler, a Geostationary Operational Environmental Satellite, and pilot reports of icing have been examined in combination with analysis fields from the Rapid Update Cycle model and forecast fields from the Pennsylvania State University/National Center for Atmospheric Research MM5 numerical model. Synthesis of this information provides a relatively complete and consistent picture of the ambient meteorological conditions in the region of the ATR72 holding pattern at 3.1 km above mean sea level. Of particular interest is the evidence that these conditions favored the development of supercooled drizzle drops within a strong frontal zone, as indicated by cloud-top temperatures of 10° to 15°C, weak radar reflectivity, and strong, vertical wind shear within the cloud and warm front.

  16. Proteomics Reveals Global Regulation of Protein SUMOylation by ATM and ATR Kinases during Replication Stress

    Directory of Open Access Journals (Sweden)

    Stephanie Munk

    2017-10-01

    Full Text Available The mechanisms that protect eukaryotic DNA during the cumbersome task of replication depend on the precise coordination of several post-translational modification (PTM-based signaling networks. Phosphorylation is a well-known regulator of the replication stress response, and recently an essential role for SUMOs (small ubiquitin-like modifiers has also been established. Here, we investigate the global interplay between phosphorylation and SUMOylation in response to replication stress. Using SUMO and phosphoproteomic technologies, we identify thousands of regulated modification sites. We find co-regulation of central DNA damage and replication stress responders, of which the ATR-activating factor TOPBP1 is the most highly regulated. Using pharmacological inhibition of the DNA damage response kinases ATR and ATM, we find that these factors regulate global protein SUMOylation in the protein networks that protect DNA upon replication stress and fork breakage, pointing to integration between phosphorylation and SUMOylation in the cellular systems that protect DNA integrity.

  17. ATR Activates the S-M Checkpoint during Unperturbed Growth to Ensure Sufficient Replication Prior to Mitotic Onset

    Directory of Open Access Journals (Sweden)

    John Kenneth Eykelenboom

    2013-11-01

    Full Text Available Cells must accurately replicate and segregate their DNA once per cell cycle in order to successfully transmit genetic information. During S phase in the presence of agents that cause replication stress, ATR-dependent checkpoints regulate origin firing and the replication machinery as well as prevent untimely mitosis. Here, we investigate the role of ATR during unperturbed growth in vertebrate cells. In the absence of ATR, individual replication forks progress more slowly, and an increased number of replication origins are activated. These cells also enter mitosis early and divide more rapidly, culminating in chromosome bridges and laggards at anaphase, failed cytokinesis, and cell death. Interestingly, cell death can be rescued by prolonging mitosis with partial inhibition of the mitotic cyclin-dependent kinase 1. Our data indicate that one of the essential roles of ATR during normal growth is to minimize the level of unreplicated DNA before the onset of mitosis.

  18. Analysis of European honeybee (Apis mellifera) wings using ATR-FTIR and Raman spectroscopy: A pilot study

    Czech Academy of Sciences Publication Activity Database

    Machovič, Vladimír; Lapčák, L.; Havelcová, Martina; Borecká, Lenka; Novotná, M.; Novotná, M.; Javůrková, I.; Langrová, I.; Hájková, Š.; Brožová, A.; Titěra, D.

    2017-01-01

    Roč. 48, č. 1 (2017), s. 22-29 ISSN 1211-3174 Institutional support: RVO:67985891 Keywords : honeybee wings * ATR-FTIR * Raman spectroscopy * protein * lipid * chitin Subject RIV: CB - Analytical Chemistry, Separation OBOR OECD: Analytical chemistry

  19. PREFACE: XXI Fluid Mechanics Conference

    Science.gov (United States)

    Szmyd, Janusz S.; Fornalik-Wajs, Elzbieta; Jaszczur, Marek

    2014-08-01

    This Conference Volume contains the papers presented at the 21st Fluid Mechanics Conference (XXI FMC) held at AGH - University of Science and Technology in Krakow, Poland, 15-18 June 2014, and accepted for Proceedings published in the Journal of Physics: Conference Series. The Fluid Mechanics Conferences have been taking place every two years since 1974, a total of forty years. The 21st Fluid Mechanics Conference (XXI FMC) is being organized under the auspices of the Polish Academy of Sciences, Committee of Mechanics. The goal of this conference is to provide a forum for the exposure and exchange of ideas, methods and results in fluid mechanics. Conference topics include, but are not limited to Aerodynamics, Atmospheric Science, Bio-Fluids, Combustion and Reacting Flows, Computational Fluid Dynamics, Experimental Fluid Mechanics, Flow Machinery, General Fluid Dynamics, Hydromechanics, Heat and Fluid Flow, Measurement Techniques, Micro- and Nano- Flow, Multi-Phase Flow, Non-Newtonian Fluids, Rotating and Stratified Flows, Turbulence. Within the general subjects of this conference, the Professor Janusz W. Elsner Competition for the best fluid mechanics paper presented during the Conference is organized. Authors holding a M.Sc. or a Ph.D. degree and who are not older than 35 years of age may enter the Competition. Authors with a Ph.D. degree must present individual papers; authors with a M.Sc. degree may present papers with their supervisor as coauthor, including original results of experimental, numerical or analytic research. Six state-of-the-art keynote papers were delivered by world leading experts. All contributed papers were peer reviewed. Recommendations were received from the International Scientific Committee, reviewers and the advisory board. Accordingly, of the 163 eligible extended abstracts submitted, after a review process by the International Scientific Committee, 137 papers were selected for presentation at the 21st Fluid Mechanics Conference, 68

  20. Determination of methyl ester contents in biodiesel blends by FTIR-ATR and FTNIR spectroscopies.

    Science.gov (United States)

    Oliveira, Jefferson S; Montalvão, Rafael; Daher, Leila; Suarez, Paulo A Z; Rubim, Joel C

    2006-07-15

    Partial last square regression (PLS) and artificial neural network (ANN) combined to FTIR-ATR and FTNIR spectroscopies have been used to design calibration models for the determination of methyl ester content (%, w/w) in biodiesel blends (methyl ester+diesel). Methyl esters were obtained by the methanolysis of soybean, babassu, dende, and soybean fried oils. Two sets of samples have been used: Group I, binary mixtures (diesel+one kind of methyl ester), corresponding to 96 biodiesel blends (0-100%, w/w), and Group II, quaternary mixtures (diesel+three types of methyl esters), corresponding to 60 biodiesel blends (0-100%, w/w). The PLS results have shown that the FTNIR model for Group I is more precise and accurate (+/-0.02 and +/-0.06%, w/w). In the case of Group II the PLS models (FTIR-ATR and FTNIR) have shown the same accuracies, while the ANN/FTNIR models has presented better performance than the ANN/FTIR-ATR models. The best accuracy was achieved by the ANN/FTNIR model for diesel determination (0.14%, w/w) while the worthiest was that of dende ANN/FTIR-ATR model (0.6%, w/w). Precisions in Group II analysis ranged from 0.06 to 0.53% (w/w) and coefficients of variation were better than 3% indicating that these models are suitable for the determination of diesel-biodiesel blends composed of methyl esters derived from different vegetable oils.

  1. Proteomics Reveals Global Regulation of Protein SUMOylation by ATM and ATR Kinases during Replication Stress

    DEFF Research Database (Denmark)

    Munk, Stephanie; Sigurðsson, Jón Otti; Xiao, Zhenyu

    2017-01-01

    The mechanisms that protect eukaryotic DNA during the cumbersome task of replication depend on the precise coordination of several post-translational modification (PTM)-based signaling networks. Phosphorylation is a well-known regulator of the replication stress response, and recently an essentia....... They analyze changes in the SUMO and phosphoproteome after MMC and hydroxyurea treatments and find that the DNA damage response kinases ATR and ATM globally regulate SUMOylation upon replication stress and fork breakage....

  2. Diamond-coated ATR prism for infrared absorption spectroscopy of surface-modified diamond nanoparticles

    Czech Academy of Sciences Publication Activity Database

    Remeš, Zdeněk; Kozak, Halyna; Rezek, Bohuslav; Ukraintsev, Egor; Babchenko, Oleg; Kromka, Alexander; Girard, H.A.; Arnault, J.-C.; Bergonzo, P.

    2013-01-01

    Roč. 270, APR (2013), s. 411-417 ISSN 0169-4332 R&D Projects: GA ČR GAP108/12/0910; GA ČR GPP205/12/P331; GA MŠk LH12236; GA MŠk LH12186 Institutional support: RVO:68378271 Keywords : ATR FTIR * CVD * hydrogenation * microwave * nanocrystalline diamond * nanopowder Subject RIV: BM - Solid Matter Physics ; Magnetism Impact factor: 2.538, year: 2013

  3. Atrésie choanale : A propos de 29 cas | Zainine | Journal Tunisien d ...

    African Journals Online (AJOL)

    Introduction : L'atrésie choanale est une malformation congénitale rare, dont la fréquence est estimée à 1 cas pour 5000 à 8000 naissances. plusieurs hypothèses embryologiques ont été proposées pour expliquer son origine. Le diagnostic de cette malformation est avant tout clinique. Objectifs : analyser les ...

  4. ATR-FTIR spectroscopy and chemometrics: An interesting tool to discriminate and characterize counterfeit medicines.

    Science.gov (United States)

    Custers, D; Cauwenbergh, T; Bothy, J L; Courselle, P; De Beer, J O; Apers, S; Deconinck, E

    2015-08-10

    Counterfeit medicines pose a huge threat to public health worldwide. High amounts of counterfeit pharmaceuticals enter the European market and therefore detection of these products is essential. Attenuated Total Reflection Fourier-Transform infrared spectroscopy (ATR-FTIR) might be useful for the screening of counterfeit medicines since it is easy to use and little sample preparation is required. Furthermore, this approach might be helpful to customs to obtain a first evaluation of suspected samples. This study proposes a combination of ATR-FTIR and chemometrics to discriminate and classify counterfeit medicines. A sample set, containing 209 samples in total, was analyzed using ATR-FTIR and the obtained spectra were used as fingerprints in the chemometric data-analysis which included Principal Component Analysis (PCA), k-Nearest Neighbours (k-NN), Classification and Regression Trees (CART) and Soft Independent Modelling of Class Analogy (SIMCA). First it was verified whether the mentioned techniques are capable to distinguish samples containing different active pharmaceutical ingredients (APIs). PCA showed a clear tendency of discrimination based on the API present; k-NN, CART and SIMCA were capable to create suitable prediction models based on the presence of different APIs. However k-NN performs the least while SIMCA performs the best. Secondly, it was tested whether these three models could be expanded to discriminate between genuine and counterfeit samples as well. k-NN was not able to make the desired discrimination and therefore it was not useful. CART performed better but also this model was less suited. SIMCA, on the other hand, resulted in a model with a 100% correct discrimination between genuine and counterfeit drugs. This study shows that chemometric analysis of ATR-FTIR fingerprints is a valuable tool to discriminate genuine from counterfeit samples and to classify counterfeit medicines. Copyright © 2014 Elsevier B.V. All rights reserved.

  5. World law

    Directory of Open Access Journals (Sweden)

    Harold J. Berman

    1999-03-01

    Full Text Available In the third millennium of the Christian era, which is characterised by the emergence of a world economy and eventually a world society, the concept of world law is needed to embrace not only the traditional disciplines of public international law, and comparative law, but also the common underlying legal principles applicable in world trade, world finance, transnational transfer of technology and other fields of world economic law, as well as in such emerging fields as the protection of the world's environment and the protection of universal human rights. World law combines inter-state law with the common law of humanity and the customary law of various world communities.

  6. 2015 NPT Review Conference and Nuclear Disarmament

    OpenAIRE

    Kurosawa, Mitsuru

    2016-01-01

    The purpose of this paper is to understand the current status of nuclear disamament and survey the future possible courses of nuclear disarmament on the basis of an examination of the arguments during the 2015 NPT Review Conference. Firtst, I will evaluate the implementation of nuclear disarmament undertakings for the last five years and consider the two most eminent topics in this Conference: the fumanitarian approach to nuclear disarmament and the legal framework for a world without nuclear...

  7. Assessing and calibrating the ATR-FTIR approach as a carbonate rock characterization tool

    Science.gov (United States)

    Henry, Delano G.; Watson, Jonathan S.; John, Cédric M.

    2017-01-01

    ATR-FTIR (attenuated total reflectance Fourier transform infrared) spectroscopy can be used as a rapid and economical tool for qualitative identification of carbonates, calcium sulphates, oxides and silicates, as well as quantitatively estimating the concentration of minerals. Over 200 powdered samples with known concentrations of two, three, four and five phase mixtures were made, then a suite of calibration curves were derived that can be used to quantify the minerals. The calibration curves in this study have an R2 that range from 0.93-0.99, a RMSE (root mean square error) of 1-5 wt.% and a maximum error of 3-10 wt.%. The calibration curves were used on 35 geological samples that have previously been studied using XRD (X-ray diffraction). The identification of the minerals using ATR-FTIR is comparable with XRD and the quantitative results have a RMSD (root mean square deviation) of 14% and 12% for calcite and dolomite respectively when compared to XRD results. ATR-FTIR is a rapid technique (identification and quantification takes < 5 min) that involves virtually no cost if the machine is available. It is a common tool in most analytical laboratories, but it also has the potential to be deployed on a rig for real-time data acquisition of the mineralogy of cores and rock chips at the surface as there is no need for special sample preparation, rapid data collection and easy analysis.

  8. Cancer cells with alternative lengthening of telomeres do not display a general hypersensitivity to ATR inhibition

    Directory of Open Access Journals (Sweden)

    Katharina I Deeg

    2016-08-01

    Full Text Available Telomere maintenance is a hallmark of cancer as it provides cancer cells with cellular immortality. A significant fraction of tumors uses the alternative lengthening of telomeres (ALT pathway to elongate their telomeres and to gain an unlimited proliferation potential. Since the ALT pathway is unique to cancer cells, it represents a potentially valuable, currently unexploited target for anticancer therapies. Recently, it was proposed that ALT renders cells hypersensitive to ataxia telangiectasia- and RAD3-related (ATR protein inhibitors (Flynn et al., Science 347, 273. Here, we measured the response of various ALT or telomerase positive cell lines to the ATR inhibitor VE-821. In addition, we compared the effect of the inhibitor on cell viability in isogenic cell lines, in which ALT was active or suppressed. In these experiments a general ATR inhibitor sensitivity of cells with ALT could not be confirmed. We rather propose that the observed variations in sensitivity reflect differences between cell lines that are unrelated to ALT.

  9. FTIR-ATR spectroscopy applied to quality control of grape-derived spirits.

    Science.gov (United States)

    Anjos, Ofélia; Santos, António J A; Estevinho, Letícia M; Caldeira, Ilda

    2016-08-15

    The Fourier transform infrared (FTIR) spectroscopic method with attenuated total reflectance (ATR) was used for predicting the alcoholic strength, the methanol, acetaldehyde and fusel alcohols content of grape-derived spirits. FTIR-ATR spectrum in the mid-IR region (4000-400 cm(-1)) was used for the quantitative estimation by applying partial least square (PLS) regression models and the results were correlated with those obtained from reference methods. In the developed method, a cross-validation with 50% of the samples was used for PLS analysis along with a validation test set with 50% of the remaining samples. Good correlation models with a great accuracy were obtained for methanol (r(2)=99.4; RPD=12.8), alcoholic strength (r(2)=97.2; RPD=6.0), acetaldehyde (r(2)=98.2; RPD=7.5) and fusel alcohols (r(2) from 97.4 to 94.1; RPD from 6.2 to 4.1). These results corroborate the hypothesis that FTIR-ATR is a useful technique for the quality control of grape-derived spirits, whose practical application may improve the efficiency and quickness of the current laboratory analysis. Copyright © 2016 Elsevier Ltd. All rights reserved.

  10. Predicting the physical properties of tablets from ATR-FTIR spectra using partial least squares regression.

    Science.gov (United States)

    Taylor, Michael; Elhissi, Abdelbary M A

    2011-04-01

    The formulation of a new tablet is a time-consuming activity involving the preparation and testing of many different formulations with the aim of identifying one with the desired properties. In complex formulations it may not be clear which excipient is responsible for eliciting a particular property. To investigate partial least squares (PLS) regression analysis of ATR-FTIR spectra of tablets as a predictive and investigative tool in the formulation of novel tablet formulations. Magnesium stearate, lactose, acetylsalicylic acid and Ac-Di-Sol. ATR-FTIR spectra of a simple aspirin tablet formulation with varying amounts of the lubricant magnesium stearate were obtained. PLS models were built using the spectral data as the multivariate variable and various physical properties of the tablets as the univariate variables. PLS models that allowed good predications to be made for samples not included in the training set were obtained for tablet hardness and disintegration time. It was clear from PLS model regression coefficients that magnesium stearate was responsible for the variation in the tablets' physical properties. PLS regression in combination with ATR-FTIR spectroscopy has been shown to be a useful approach for the prediction of the physical properties of tablets.

  11. Fast quantitative determination of microbial rhamnolipids from cultivation broths by ATR-FTIR Spectroscopy

    Directory of Open Access Journals (Sweden)

    Hausmann Rudolf

    2008-10-01

    Full Text Available Abstract Background Vibrational spectroscopic techniques are becoming increasingly important and popular because they have the potential to provide rapid and convenient solutions to routine analytical problems. Using these techniques, a variety of substances can be characterized, identified and also quantified rapidly. Results The rapid ATR-FTIR (Attenuated Total Reflectance Fourier Transform Infrared Spectroscopy in time technique has been applied, which is suitable to quantify the concentrations of microbial rhamnolipids in a typical cultivation process. While the usually applied HPLC analysis requires an extensive and time consuming multi step extraction protocol for sample preparation, the ATR-FTIR-method allows the quantification of the rhamnolipids within 20 minutes. Accuracies between 0.5 g/l – 2.1 g/l for the different analytes were determined by cross validation of the calibration set. Even better accuracies between 0.28 g/l – 0.59 g/l were found for independent test samples of an arbitrarily selected cultivation. Conclusion ATR-FTIR was found to be suitable for the rapid analysis of rhamnolipids in a biotechnological process with good reproducibility in sample determination and sufficient accuracy. An improvement in accuracy through continuous expansion and validation of the reference spectra set seems very likely.

  12. Diamond-coated ATR prism for infrared absorption spectroscopy of surface-modified diamond nanoparticles

    Energy Technology Data Exchange (ETDEWEB)

    Remes, Z., E-mail: remes@fzu.cz [Institute of Physics of the ASCR, v.v.i., Cukrovarnicka 10, Praha 6 (Czech Republic); Kozak, H.; Rezek, B.; Ukraintsev, E.; Babchenko, O.; Kromka, A. [Institute of Physics of the ASCR, v.v.i., Cukrovarnicka 10, Praha 6 (Czech Republic); Girard, H.A.; Arnault, J.-C.; Bergonzo, P. [CEA, LIST, Diamond Sensors Laboratory, F-91191 Gif-sur-Yvette (France)

    2013-04-01

    Linear antenna microwave chemical vapor deposition process was used to homogeneously coat a 7 cm long silicon prism by 85 nm thin nanocrystalline diamond (NCD) layer. To show the advantages of the NCD-coated prism for attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR) of nanoparticles, we apply diamond nanoparticles (DNPs) of 5 nm nominal size with various surface modifications by a drop-casting of their methanol dispersions. ATR-FTIR spectra of as-received, air-annealed, plasma-oxidized, and plasma-hydrogenated DNPs were measured in the 4000–1500 cm{sup −1} spectral range. The spectra show high spectral resolution, high sensitivity to specific DNP surface moieties, and repeatability. The NCD coating provides mechanical protection against scratching and chemical stability of the surface. Moreover, unlike on bare Si surface, NCD hydrophilic properties enable optically homogeneous coverage by DNPs with some aggregation on submicron scale as evidenced by scanning electron microscopy and atomic force microscopy. Compared to transmission FTIR regime with KBr pellets, direct and uniform deposition of DNPs on NCD-ATR prism significantly simplifies and speeds up the analysis (from days to minutes). We discuss prospects for in situ monitoring of surface modifications and molecular grafting.

  13. Submission of FeCrAl Feedstock for Support of AFC ATR-2 Irradiations

    Energy Technology Data Exchange (ETDEWEB)

    Field, Kevin G. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Barrett, Kristine E. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Sun, Zhiqian [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Yamamoto, Yukinori [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2016-09-16

    The Advanced Test Reactor (ATR) is currently being used to test accident tolerant fuel (ATF) forms destined for commercial nuclear power plant deployment. One irradiation program using the ATR for ATF concepts, Accident Tolerant Fuel-2 (ATF-2), is a water loop irradiation test using miniaturized fuel pins as test articles. This complicated testing configuration requires a series of pre-test experiments and verification including a flowing loop autoclave test and a sensor qualification test (SQT) prior to full test train deployment within the ATR. In support of the ATF-2 irradiation program, Oak Ridge National Laboratory (ORNL) has supplied two different Generation II FeCrAl alloys in rod stock form to Idaho National Laboratory (INL). These rods will be machined into dummy pins for deployment in the autoclave test and SQT. Post-test analysis of the dummy pins will provide initial insight into the performance of Generation II FeCrAl alloys in the ATF-2 irradiation experiment as well as within a commercial nuclear reactor.

  14. MELT WIRE SENSORS AVAILABLE TO DETERMINE PEAK TEMPERATURES IN ATR IRRADIATION TESTING

    Energy Technology Data Exchange (ETDEWEB)

    K. L. Davis; D. Knudson; J. Daw; J. Palmer; J. L. Rempe

    2012-07-01

    In April 2007, the Department of Energy (DOE) designated the Advanced Test Reactor (ATR) a National Scientific User Facility (NSUF) to advance US leadership in nuclear science and technology. By attracting new users from universities, laboratories, and industry, the ATR will support basic and applied nuclear research and development and help address the nation's energy security needs. In support of this new program, the Idaho National Laboratory (INL) has developed in-house capabilities to fabricate, test, and qualify new and enhanced temperature sensors for irradiation testing. Although most efforts emphasize sensors capable of providing real-time data, selected tasks have been completed to enhance sensors provided in irradiation locations where instrumentation leads cannot be included, such as drop-in capsule and Hydraulic Shuttle Irradiation System (HSIS) or 'rabbit' locations. To meet the need for these locations, the INL has developed melt wire temperature sensors for use in ATR irradiation testing. Differential scanning calorimetry and environmental testing of prototypical sensors was used to develop a library of 28 melt wire materials, capable of detecting peak irradiation temperatures ranging from 85 to 1500°C. This paper will discuss the development work and present test results.

  15. Cyclohexene Photo-oxidation over Vanadia Catalyst Analyzed by Time Resolved ATR-FT-IR Spectroscopy

    Energy Technology Data Exchange (ETDEWEB)

    Frei, Heinz; Mul, Guido; Wasylenko, Walter; Hamdy, M. Sameh; Frei, Heinz

    2008-06-04

    Vanadia was incorporated in the 3-dimensional mesoporous material TUD-1 with a loading of 2percent w/w vanadia. The performance in the selective photo-oxidation of liquid cyclohexene was investigated using ATR-FT-IR spectroscopy. Under continuous illumination at 458 nm a significant amount of product, i.e. cyclohexenone, was identified. This demonstrates for the first time that hydroxylated vanadia centers in mesoporous materials can be activated by visible light to induce oxidation reactions. Using the rapid scan method, a strong perturbation of the vanadyl environment could be observed in the selective oxidation process induced by a 458 nm laser pulse of 480 ms duration. This is proposed to be caused by interaction of the catalytic centre with a cyclohexenyl hydroperoxide intermediate. The restoration of the vanadyl environment could be kinetically correlated to the rate of formation of cyclohexenone, and is explained by molecular rearrangement and dissociation of the peroxide to ketone and water. The ketone diffuses away from the active center and ATR infrared probing zone, resulting in a decreasing ketone signal on the tens of seconds time scale after initiation of the photoreaction. This study demonstrates the high potential of time resolved ATR FT-IR spectroscopy for mechanistic studies of liquid phase reactions by monitoring not only intermediates and products, but by correlating the temporal behavior of these species to molecular changes of the vanadyl catalytic site.

  16. Nostradamus conference 2013

    CERN Document Server

    Chen, Guanrong; Rössler, Otto; Snasel, Vaclav; Abraham, Ajith; Nostradamus 2013: Prediction, Modeling and Analysis of Complex Systems

    2013-01-01

    Prediction of behavior of the dynamical systems, analysis and modeling of its structure is vitally important problem in engineering, economy and science today. Examples of such systems can be seen in the world around us and of course in almost every scientific discipline including such “exotic” domains like the earth’s atmosphere, turbulent fluids, economies (exchange rate and stock markets), population growth, physics (control of plasma), information flow in social networks and its dynamics, chemistry and complex networks. To understand such dynamics and to use it in research or industrial applications, it is important to create its models. For this purpose there is rich spectra of methods, from classical like ARMA models or Box Jenkins method to such modern ones like evolutionary computation, neural networks, fuzzy logic, fractal geometry, deterministic chaos and more. This proceeding book is a collection of the accepted papers to conference Nostradamus that has been held in Ostrava, Czech Republic. P...

  17. Conference summary

    Energy Technology Data Exchange (ETDEWEB)

    Seestrom, S.J.

    1993-10-06

    The conference began with an introductory lecture by Bunakov. It is very appropriate that this workshop be held in Dubna as Bunakov reminded us that the experiments that motivated the current interest in the study of symmetry violation with neutrons were started here at Dubna by Alfimenkov, Pikelner, and collaborators. Bunakov discussed the fact that is the complexity of the compound nucleus that leads to large enhancement of parity violation near P-resonances and to the possibility of using statistical models to relate the measured parity violation to more-fundamental quantities. He also pointed out that it is a rare case in which complexity aids us. Bunakov did not point out that this is an example of another rare phenomena -- where theory has predicted correctly in advance the parity violating effects seen near p-resonances. As long ago as 1969, Karmanov and Lobov first predicted an enhancement of {gamma}-ray circular polarization near p-resonances. Sushkov and Flambaum later predicted asymmetries P {approximately} 10{sup {minus}2} for p-resonances and suggested {sup 117}Sn, {sup 139}La, {sup 232}Th, and {sup 238}U for study. Bunakov and Gudkov developed a theory describing the energy dependence of parity-violating effects over a large energy range. This theory predicted random signs for the parity-violating asymmetries.

  18. International Conference on Theoretical and Computational Physics

    CERN Document Server

    2016-01-01

    Int'l Conference on Theoretical and Computational Physics (TCP 2016) will be held from August 24 to 26, 2016 in Xi'an, China. This Conference will cover issues on Theoretical and Computational Physics. It dedicates to creating a stage for exchanging the latest research results and sharing the advanced research methods. TCP 2016 will be an important platform for inspiring international and interdisciplinary exchange at the forefront of Theoretical and Computational Physics. The Conference will bring together researchers, engineers, technicians and academicians from all over the world, and we cordially invite you to take this opportunity to join us for academic exchange and visit the ancient city of Xi’an.

  19. Worlds Fantastic, Worlds Familiar

    Science.gov (United States)

    Buratti, Bonnie J.

    2017-02-01

    Introduction; 1. Mercury: the hottest little place; 2. Venus: an even hotter place; 3. Mars: the abode of life?; 4. Asteroids and comets: sweat the small stuff; 5. Galileo's treasures: worlds of fire and ice; 6. Enceladus: an active iceball in space; 7. Titan: an Earth in deep freeze?; 8. Iapetus and its friends: the weirdest 'planets' in the Solar System; 9. Pluto: the first view of the 'third zone'; 10. Earths above: the search for exoplanets and life in the universe; Epilogue; Glossary; Acknowledgements; Index.

  20. The ATM- and ATR-related SCD domain is over-represented in proteins involved in nervous system development.

    Science.gov (United States)

    Cara, Lukas; Baitemirova, Medina; Follis, Jack; Larios-Sanz, Maia; Ribes-Zamora, Albert

    2016-01-08

    ATM and ATR are cellular kinases with a well-characterized role in the DNA-damage response. Although the complete set of ATM/ATR targets is unknown, they often contain clusters of S/TQ motifs that constitute an SCD domain. In this study, we identified putative ATM/ATR targets that have a conserved SCD domain across vertebrates. Using this approach, we have identified novel putative ATM/ATR targets in pathways known to be under direct control of these kinases. Our analysis has also unveiled significant enrichment of SCD-containing proteins in cellular pathways, such as vesicle trafficking and actin cytoskeleton, where a regulating role for ATM/ATR is either unknown or poorly understood, hinting at a much broader and overarching role for these kinases in the cell. Of particular note is the overrepresentation of conserved SCD-containing proteins involved in pathways related to neural development. This finding suggests that ATM/ATR could be directly involved in controlling this process, which may be linked to the adverse neurological effects observed in patients with mutations in ATM.

  1. Science in the Muslim world

    Science.gov (United States)

    Al-Khalili, Jim

    2010-04-01

    There are more than a billion Muslims in the world today - over a fifth of the world's total population - spread over many more than the 57 member states of the Organisation of the Islamic Conference (OIC) in which Islam is the official religion. These include some of the world's wealthiest nations, such as Saudi Arabia and Kuwait, as well as some of the poorest, like Somalia and Sudan. The economies of some of these countries - such as the Gulf States, Iran, Turkey, Egypt, Morocco, Malaysia and Pakistan - have been growing steadily for a number of years, and yet, in comparison with the West, the Islamic world still appears somewhat disengaged from modern science.

  2. Connecting Narrative Worlds [6th International Conference for Interactive Digital Storytelling: “Connecting Narrative Worlds”, Bahçeşehir University Istanbul, November 6-9, 2013

    Directory of Open Access Journals (Sweden)

    Hartmut Koenitz

    2014-06-01

    Full Text Available Tagungsbericht zu / Conference report of: Normal 0 21 false false false DE X-NONE X-NONE /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Normale Tabelle"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman","serif";} 6th International Conference for Interactive Digital Storytelling: “Connecting Narrative Worlds”, Bahçeşehir University Istanbul, November 6-9, 2013

  3. WebWise 2.0: The Power of Community. WebWise Conference on Libraries and Museums in the Digital World Proceedings (9th, Miami Beach, Florida, March 5-7, 2008)

    Science.gov (United States)

    Green, David

    2009-01-01

    Since it was coined by Tim O'Reilly in formulating the first Web 2.0 Conference in 2004, the term "Web 2.0" has definitely caught on as a designation of a second generation of Web design and experience that emphasizes a high degree of interaction with, and among, users. Rather than simply consulting and reading Web pages, the Web 2.0 generation is…

  4. Energy for tomorrows world: time for action: the year 2000 declaration of the Worldwide Conference on Energy; L'energie pour le monde de demain: le temps de l'action: declaration 2000 du CME

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-07-01

    This document makes a status of the evolutions in the energy sector since 1993 and presents the statistical bases and prospective scenarios used today by the Worldwide Conference on Energy. It stresses on the strategy to be adopted in order to answer the three main objectives: accessibility, availability, acceptability. The strategy is defined by a 10 priority actions plan for a durable development. (J.S.)

  5. ATR preferentially interacts with common fragile site FRA3B and the binding requires its kinase activity in response to aphidicolin treatment.

    Science.gov (United States)

    Wan, Cheng; Kulkarni, Atul; Wang, Yuh-Hwa

    2010-04-01

    The instability of common fragile sites (CFSs) contributes to the development of a variety of cancers. The ATR-dependent DNA damage checkpoint pathway has been implicated in maintaining CFS stability, but the mechanism is incompletely understood. The goal of our study was to elucidate the action of the ATR protein in the CFS-specific ATR-dependent checkpoint response. Using a chromatin immunoprecipitation assay, we demonstrated that ATR protein preferentially binds (directly or through complexes) to fragile site FRA3B as compared to non-fragile site regions, under conditions of mild replication stress. Interestingly, the amount of ATR protein that bound to three regions of FRA3B peaked at 0.4microM aphidicolin (APH) treatment and decreased again at higher concentrations of APH. The total amounts of cellular ATR and several ATR-interacting proteins remained unchanged, suggesting that ATR binding to the fragile site is guided initially by the level of replication stress signals generated at FRA3B due to APH treatment and then sequestered from FRA3B regions by successive signals from other non-fragile site regions, which are produced at the higher concentrations of APH. This decrease in ATR binding to fragile site FRA3B at the higher concentrations of APH may account for the increasing number of chromosome gaps and breaks observed under the same conditions. Furthermore, inhibition of ATR kinase activity by treatment with 2-aminopurine (2-AP) or by over-expression of a kinase-dead ATR mutant showed that the kinase activity is required for the binding of ATR to fragile DNAs in response to APH treatment. Our results provide novel insight into the mechanism for the regulation of fragile site stability by ATR. Copyright 2010 Elsevier B.V. All rights reserved.

  6. [World deliberations in Rio].

    Science.gov (United States)

    Annis, B

    1991-01-01

    The United Nations Conference on Environment and Development (UNCED) was held in Rio de Janeiro in June 1992 and dealt with world trade, environmental education, environmental emergencies, the transfer of technology and financial resources, and the restructuring of international systems for tackling environmental problems. Other issues on the agenda were the protection of the atmosphere, the ozone shield, deforestation, the conservation of biological diversity, sustainable urban and rural development, and the safeguarding of human health and quality of life. The preparation for the conference took place through a series of meetings, which also featured the problems of rural areas in the Americas. Some environmental organizations based in Washington, D.C. had become impassive over the years and promoted bipartisan and apolitical issues in order to obtain funds. Nonetheless, some groups criticized the projects of the World Bank. In 1990 the World Bank established the World Environmental Program for developing countries, which envisioned the execution of 15 projects and 11 technical assistance proposals. Nongovernmental organizations (NGOs) were also active in this effort. The Interamerican Development Bank also launched a forest policy for preserving forest resources. This was the consequence of the 1982 scheme that aimed at protecting forest populations and promoting sustainable forest industries. At another conference of development specialists the discrimination against women was cited as a major factor in the deleterious use of natural resources. A new development concept was urged that would incorporate the rights and participation of women as a central strategy in solving the global environmental crisis. The global population is growing at a rate of 95 million people per year, which underlines the need for better representation of women, poor people, and rural areas in state agencies and multilateral and environmental organizations for promoting sustainable

  7. 2nd International Conference on Intelligent Transportation

    CERN Document Server

    2017-01-01

    These proceedings present the latest information on intelligent- transportation technologies and their applications in real-world cases. The Second International Conference on Intelligent Transportation was held in Chengdu, China on November 25–27, 2015, to present the latest research in the field, including intelligent-transportation management, intelligent vehicles, rail transportation systems, traffic transportation networks, as well as road traffic element simulations and their industrial development. The aim of conference was to bring together academics, researchers, engineers and students from across the world to discuss state-of-the-art technologies related to intelligent transportation.

  8. Conference this! Lead Pipers compare conference experiences

    Directory of Open Access Journals (Sweden)

    Editorial Board

    2010-04-01

    Full Text Available As library travel budgets are increasingly slashed around the country, it’s a tough time for conference-going. In this group post, we compare notes about the conferences we’ve attended, which have been our favorites, and why. We hope this will generate creative ideas on good conferences (online or in-person to look forward to, and maybe offer [...

  9. ATR, Claspin and the Rad9-Rad1-Hus1 complex regulate Chk1 and Cdc25A in the absence of DNA damage

    DEFF Research Database (Denmark)

    Sørensen, Claus Storgaard; Syljuåsen, Randi G; Lukas, Jiri

    2004-01-01

    The ATR and Chk1 kinases are essential to maintain genomic integrity. ATR, with Claspin and the Rad9-Rad1-Hus1 complex, activates Chk1 after DNA damage. Chk1-mediated phosphorylation of the Cdc25A phosphatase is required for the mammalian S-phase checkpoint. Here, we show that during physiological...... S phase the regulation of the Chk1-Cdc25A pathway depends on ATR, Claspin, Rad9, and Hus1. Human cells with chemically or genetically ablated ATR showed inhibition of Chk1-dependent phosphorylation of Cdc25A, and they accumulated Cdc25A without external DNA damage. Furthermore, si......RNA-mediated depletion of Claspin, Rad9 and Hus1 also stabilized Cdc25A. ATR ablation also inhibited the activatory phosphorylation of Chk1 on serine 345. Thus, the ATR-Chk1-Cdc25A pathway represents an integral part of physiological S-phase progression, and interference with this mechanism undermines viability...

  10. International conference centre, Geneva, Switzerland

    CERN Multimedia

    PH Department

    2009-01-01

    On 16-17 March 2009 the Energy Pact Foundation will be holding the Energy Pact Conference in Geneva. The Conference is organised with the support of the Republic and Canton of Geneva and has the Financial Times as its media partner. It will address for the first time in a comprehensive and integrated manner the key issues of energy needs and environmental and developmental challenges. Some 800 stakeholders and experts on these issues are expected. These will include high-level government officials, opinion leaders and representatives from the United Nations, NGOs, industry, civil society and the academic world. Gerhard Schröder, former Chancellor of Germany, will chair the Conference. Speakers with different backgrounds and expertise will include Dr. Carlo Rubia, Nobel Prize Winner, Ali Al-Naimi, Minister of Petroleum and Mineral Resources of Saudi Arabia, Gholam Hossein Nozari, Oil Minister of Iran, Gary Ross, CEO of PIRA Energy, a world-renowned energy market specialist, Ashok Khosla, President of the In...

  11. ATR- and ATM-Mediated DNA Damage Response Is Dependent on Excision Repair Assembly during G1 but Not in S Phase of Cell Cycle.

    Science.gov (United States)

    Ray, Alo; Blevins, Chessica; Wani, Gulzar; Wani, Altaf A

    2016-01-01

    Cell cycle checkpoint is mediated by ATR and ATM kinases, as a prompt early response to a variety of DNA insults, and culminates in a highly orchestrated signal transduction cascade. Previously, we defined the regulatory role of nucleotide excision repair (NER) factors, DDB2 and XPC, in checkpoint and ATR/ATM-dependent repair pathway via ATR and ATM phosphorylation and recruitment to ultraviolet radiation (UVR)-induced damage sites. Here, we have dissected the molecular mechanisms of DDB2- and XPC- mediated regulation of ATR and ATM recruitment and activation upon UVR exposures. We show that the ATR and ATM activation and accumulation to UVR-induced damage not only depends on DDB2 and XPC, but also on the NER protein XPA, suggesting that the assembly of an active NER complex is essential for ATR and ATM recruitment. ATR and ATM localization and H2AX phosphorylation at the lesion sites occur as early as ten minutes in asynchronous as well as G1 arrested cells, showing that repair and checkpoint-mediated by ATR and ATM starts early upon UV irradiation. Moreover, our results demonstrated that ATR and ATM recruitment and H2AX phosphorylation are dependent on NER proteins in G1 phase, but not in S phase. We reasoned that in G1 the UVR-induced ssDNA gaps or processed ssDNA, and the bound NER complex promote ATR and ATM recruitment. In S phase, when the UV lesions result in stalled replication forks with long single-stranded DNA, ATR and ATM recruitment to these sites is regulated by different sets of proteins. Taken together, these results provide evidence that UVR-induced ATR and ATM recruitment and activation differ in G1 and S phases due to the existence of distinct types of DNA lesions, which promote assembly of different proteins involved in the process of DNA repair and checkpoint activation.

  12. Identification of two novel regulatory genes involved in pristinamycin biosynthesis and elucidation of the mechanism for AtrA-p-mediated regulation in Streptomyces pristinaespiralis.

    Science.gov (United States)

    Wang, Wenfang; Tian, Jinzhong; Li, Lei; Ge, Mei; Zhu, Hong; Zheng, Guosong; Huang, He; Ruan, Lijun; Jiang, Weihong; Lu, Yinhua

    2015-09-01

    In this study, using a transposon-based strategy, two novel regulatory genes were identified as being involved in the biosynthesis of both pristinamycin I (PI) and II (PII) in Streptomyces pristinaespiralis, including a TetR-family regulatory gene atrA-p (SSDG_00466) and an orphan histidine kinase gene SSDG_02492. The mechanism by which AtrA-p exerted a positive role in pristinamycin production was elucidated. We showed that deletion of atrA-p resulted in a delayed production of both PI and PII as well as reduced PII production. Transcriptional analysis integrated with electrophoretic mobility shift assays (EMSAs) demonstrated that AtrA-p played a positive role in pristinamycin production by directly activating the transcription of two cluster-situated regulatory genes, spbR and papR5, which encode a γ-butyrolactone receptor protein and a TetR-family repressor, respectively. The precise AtrA-p-binding sites upstream of these two targets were determined, which allowed the identification of a relatively conserved binding motif comprising two 5-nt inverted repeats separated by a variable 5-nt sequence (5'-GGAAT-n5-ATTCC-3') possibly required for the regulation of AtrA-like regulators in Streptomyces. Base substitutions of the AtrA-p-binding sites on the genome caused similar decreases in spbR and papR5 transcription as those observed in ∆atrA-p. Taken together, herein, a novel mechanism for AtrA-dependent regulation of antibiotic biosynthesis was revealed in S. pristinaespiralis, which is distinct from those of its homologs, AtrA-c from Streptomyces coelicolor, AtrA-g from Streptomyces griseus, and AtrA from Streptomyces roseosporus that perform their effects in antibiotic biosynthesis directly via pathway-specific activator genes or the biosynthetic structural genes.

  13. 76 FR 64083 - Reliability Technical Conference; Notice of Technical Conference

    Science.gov (United States)

    2011-10-17

    ... Energy Regulatory Commission Reliability Technical Conference; Notice of Technical Conference Take notice that the Federal Energy Regulatory Commission will hold a Technical Conference on Tuesday, November 29... addressing risks to reliability that were identified in earlier Commission technical conferences. The...

  14. Drosophila dSmad2 and Atr-I transmit activin/TGFbeta signals.

    Science.gov (United States)

    Das, P; Inoue, H; Baker, J C; Beppu, H; Kawabata, M; Harland, R M; Miyazono, K; Padgett, R W

    1999-02-01

    Much is known about the three subfamilies of the TGFbeta superfamily in vertebrates-the TGFbetas, dpp/BMPs, and activins. Signalling in each subfamily is dependent on both shared and unique cell surface receptors and Smads. In invertebrates, mutants for BMP pathway components have been extensively characterized, but thus far, evidence for an activin- or TGFbeta-like pathway has been lacking, preventing the use of the extensive genetic tools available for studying several key issues of TGFbeta signalling. Here we report the identification of dSmad2, a new Drosophila Smad which is most related to the activin/TGFbeta-pathway Smads, Smad2 and Smad3. We show that dSmad2 induces activin responsive genes in Xenopus animal cap assays. dSMAD2 is phosphorylated by ATR-I and PUNT, but not by activated THICK VEINS, and translocates to the nucleus upon activation. Furthermore, we show that dSMAD2 complexes with MEDEA only in the presence of ATR-I and PUNT. dSmad2 is expressed in the imaginal disks and in the outer proliferation centre of the larval brain, suggesting that it may have important proliferative and patterning roles during Drosophila development. Our data provide evidence for the existence of an activin/TGFbeta pathway in Drosophila. We show that dSmad2 participates in this pathway, and that it functions with Atr-I and punt. We show that Medea also participates in this pathway, indicating the conservation of roles for Co-Smads in diverse phyla. Expression patterns of dSmad2 suggest that it functions in imaginal disks and in the brain, in tissues that undergo extensive patterning and proliferation.

  15. Root discrimination of closely related crop and weed species using FT MIR-ATR spectroscopy

    Directory of Open Access Journals (Sweden)

    Catharina eMeinen

    2015-09-01

    Full Text Available Root discrimination of species is a pre-condition for studying belowground competition processes between crop and weed species. In this experiment, we tested Fourier transform mid-infrared (FT MIR-attenuated total reflection (ATR spectroscopy to discriminate roots of closely related crop and weed species grown in the greenhouse: maize/barnyard grass, barley/wild oat, wheat/blackgrass (Poaceae, and sugar beet/common lambsquarters (Chenopodiaceae. Fresh (moist and dried root segments as well as ground roots were analyzed by FT MIR-ATR spectroscopy. Root absorption spectra showed species specific peak distribution and peak height. A clear separation according to species was not possible with fresh root segments. Dried root segments (including root basis, middle section and root tip of maize/barnyard grass and sugar beet/common lambsquarters formed completely separated species clusters. Wheat and blackgrass separated in species specific clusters when root tips were removed from cluster analysis. A clear separation of dried root segments according to species was not possible in the case of barley and wild oat. Cluster analyses of ground roots revealed a 100 % separation of all tested crop and weed species combinations. Spectra grouped in Poaceae and Chenopodiaceae clusters. Within the Poaceae cluster, C3 and C4 species differed significantly in heterogeneity. Thus, root spectra reflected the degree of kinship. To quantify species proportion in root mixtures, a two- and a three-species model for species quantification in root mixtures of maize, barnyard grass, and wild oat was calculated. The models showed low standard errors of prediction (RMSEP and high residual predictive deviation (RPD values in an external test set validation. Hence, FT MIR-ATR spectroscopy seems to be a promising tool for root research even between closely related plant species.

  16. AGR-3/4 Final Data Qualification Report for ATR Cycles 151A through 155B-1

    Energy Technology Data Exchange (ETDEWEB)

    Pham, Binh T. [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2015-03-01

    This report provides the qualification status of experimental data for the entire Advanced Gas Reactor 3/4 (AGR 3/4) fuel irradiation. AGR-3/4 is the third in a series of planned irradiation experiments conducted in the Advanced Test Reactor (ATR) at Idaho National Laboratory (INL) for the AGR Fuel Development and Qualification Program, which supports development of the advanced reactor technology under the INL ART Technology Development Office (TDO). The main objective of AGR-3/4 irradiation is to provide a known source of fission products for subsequent transport through compact matrix and structural graphite materials due to the presence of designed-to-fail fuel particles. Full power irradiation of the AGR 3/4 test began on December 14, 2011 (ATR Cycle 151A), and was completed on April 12, 2014 (end of ATR Cycle 155B) after 369.1 effective full power days of irradiation. The AGR-3/4 test was in the reactor core for eight of the ten ATR cycles between 151A and 155B. During the unplanned outage cycle, 153A, the experiment was removed from the ATR northeast flux trap (NEFT) location and stored in the ATR canal. This was to prevent overheating of fuel compacts due to higher than normal ATR power during the subsequent Powered Axial Locator Mechanism cycle, 153B. The AGR 3/4 test was inserted back into the ATR NEFT location during the outage of ATR Cycle 154A on April 26, 2013. Therefore, the AGR-3/4 irradiation data received during these 2 cycles (153A and 153B) are irrelevant and their qualification status isnot included in this report. Additionally, during ATR Cycle 152A the ATR core ran at low power for a short enough duration that the irradiation data are not used for physics and thermal calculations. However, the qualification status of irradiation data for this cycle is still covered in this report. As a result, this report includes data from 8 ATR Cycles: 151A, 151B, 152A, 152B, 154A, 154B, 155A, and 155B, as recorded in the Nuclear Data Management and

  17. The Third International Conference on Artificial Intelligence and Education

    OpenAIRE

    Liffick, Blaise W.

    1987-01-01

    The Third International Conference on Artificial Intelligence and Education attracted over 400 participants from all over the world who gathered to present projects reports, exchange views, discuss common problems, and establish contacts concerning AI and education. This article presents a synopsis of the major presentations and an overview of the conference as a whole.

  18. BCES: A Fifteen-Year Conference Tradition

    Directory of Open Access Journals (Sweden)

    Nikolay Popov

    2017-05-01

    Full Text Available This volume contains selected papers submitted to the XV Annual International Conference of the Bulgarian Comparative Education Society (BCES, held in June 2017 in Borovets, Bulgaria, and papers submitted to the V International Partner Conference of the International Research Centre (IRC ‘Scientific cooperation’, Rostov-on-Don, Russia, organized as part of the BCES Conference. The XV BCES Conference theme is Current Business and Economics Driven Discourse and Education: Perspectives from Around the World. The V International Partner Conference theme is Science and Education in Modern Social, Economic and Humanitarian Discourse. The book consists of 38 papers written by 69 authors. The volume starts with an introductory paper by Johannes L van der Walt. The other 37 papers are divided into 8 parts: 1 Comparative Education & History of Education; 2 Teacher Education; 3 Education Policy, Reforms & School Leadership; 4 Higher Education, Lifelong Learning & Social Inclusion; 5 Law and Education; 6 Research Education; 7 Educational Development Strategies in Different Countries and Regions of the World; 8 Key Directions and Characteristics of Research Organization in the Contemporary World.

  19. Shear Punch Testing on ATR Irradiated MA956 FeCrAl Alloy

    Energy Technology Data Exchange (ETDEWEB)

    Saleh, Tarik A. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Quintana, Matthew Estevan [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Romero, Tobias J. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2017-06-13

    The shear punch testing of irradiated and control MA956 (FeCrAl) Alloy from the NSUF-ATR-UCSB irradiation is presented. This is the first data taken on a new shear punch fixture design to test three 1.5mm punches from each 8mm x 0.5mm Disc Multipurpose Coupon (DMC). Samples were irradiated to 6.1dpa at a temperature of 315°C and 6.2 dpa at 400°C.

  20. Characterisation Of Polysacharides And Lipids From Selected Green Algae Species By FTIR-ATR Spectroscopy

    Directory of Open Access Journals (Sweden)

    Bartošová Alica

    2015-06-01

    Full Text Available Fourier transform infrared (FTIR spectroscopy was used in this study to identify and determine spectral features of Chromochloris zofingiensis (Dönz Fucíková et L.A. Lewis (SAG 211-14, Gottingen, Germany, Acutodesmus obliguus (Turpin Hegewald (SAG 276-1, Gottingen, Germany and Chlorella sorokiniana (K. Brandt Pröschold et Darienko (SAG 211-40c, Gottingen, Germany. Polysaccharides and lipids from these three algae species were determined using Fourier Transformed Infrared Spectroscopy (FTIR with ATR accessory with diamante crystal in spectral range from 400 – 4000 cm−1 and resolution 4.

  1. Radar automatic target recognition (ATR) and non-cooperative target recognition (NCTR)

    CERN Document Server

    Blacknell, David

    2013-01-01

    The ability to detect and locate targets by day or night, over wide areas, regardless of weather conditions has long made radar a key sensor in many military and civil applications. However, the ability to automatically and reliably distinguish different targets represents a difficult challenge. Radar Automatic Target Recognition (ATR) and Non-Cooperative Target Recognition (NCTR) captures material presented in the NATO SET-172 lecture series to provide an overview of the state-of-the-art and continuing challenges of radar target recognition. Topics covered include the problem as applied to th

  2. Binding of a biosynthetic intermediate to AtrA modulates the production of lidamycin by Streptomyces globisporus.

    Science.gov (United States)

    Li, Xingxing; Yu, Tengfei; He, Qing; McDowall, Kenneth J; Jiang, Bingya; Jiang, Zhibo; Wu, Linzhuan; Li, Guangwei; Li, Qinglian; Wang, Songmei; Shi, Yuanyuan; Wang, Lifei; Hong, Bin

    2015-06-01

    The control of secondary production in streptomycetes involves the funneling of environmental and physiological signals to the cluster-situated (transcriptional) regulators (CSRs) of the biosynthetic genes. For some systems, the binding of biosynthetic products to the CSR has been shown to provide negative feedback. Here we show for the production of lidamycin (C-1027), a clinically relevant antitumor agent, by Streptomyces globisporus that negative feedback can extend to a point higher in the regulatory cascade. We show that the DNA-binding activity of the S. globisporus orthologue of AtrA, which was initially described as a transcriptional activator of actinorhodin biosynthesis in S. coelicolor, is inhibited by the binding of heptaene, a biosynthetic intermediate of lidamycin. Additional experiments described here show that S. globisporus AtrA binds in vivo as well as in vitro to the promoter region of the gene encoding SgcR1, one of the CSRs of lidamycin production. The feedback to the pleiotropic regulator AtrA is likely to provide a mechanism for coordinating the production of lidamycin with that of other secondary metabolites. The activity of AtrA is also regulated by actinorhodin. As AtrA is evolutionarily conserved, negative feedback of the type described here may be widespread within the streptomycetes. © 2015 John Wiley & Sons Ltd.

  3. Climate Science Conference

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — The North Pacific LCC is helping sponsor the Second Annual Pacific Northwest Climate Science Conference. This two day, regional conference included a panel...

  4. Student Support for EIPBN 2010 Conference

    Energy Technology Data Exchange (ETDEWEB)

    Reginald C. Farrow

    2011-03-11

    The 54th International Conference on Electron, Ion and Photon Beam Technology and Nanofabrication, 2010, held at the Egan Convention Center and Hilton in Anchorage, Alaska, June 1 to 4, 2010 was a great success in large part because financial support allowed robust participation from students. The conference brought together 444 engineers and scientists from industries and universities from all over the world to discuss recent progress and future trends. Among the emerging technologies that are within the scope of EIPBN is Nanofabrication for Energy Sources along with nanofabrication for the realization of low power integrated circuits. Every year, EIPBN provides financial support for students to attend the conference.The students gave oral and poster presentations of their research and many published peer reviewed articles in a special conference issue of the Journal of Vacuum Science and Technology B. The Department of Energy Office of Basic Energy Sciences supported 20 students from US universities with a $15,000.

  5. Fake/Bogus Conferences

    DEFF Research Database (Denmark)

    Asadi, Amin; Rahbar, Nader; Rezvani, Mohammad Javad

    2017-01-01

    The main objective of the present paper is to introduce some features of fake/bogus conferences and some viable approaches to differentiate them from the real ones. These fake/bogus conferences introduce themselves as international conferences, which are multidisciplinary and indexed in major sci...... scientific digital libraries. Furthermore, most of the fake/bogus conference holders offer publishing the accepted papers in ISI journals and use other techniques in their advertisement e-mails....

  6. PREFACE: International Conference on Electrical Bioimpedance

    Science.gov (United States)

    Sadleir, Rosalind; Woo, Eung Je

    2010-04-01

    logo The XIVth International Conference on Electrical Bioimpedance, held in conjunction with the 11th Conference on Biomedical Applications of EIT (ICEBI & EIT 2010), took place from 4-8 April 2010 in the Reitz Union of the University of Florida, in Gainesville, USA. This was the first time since its inception in 1969 that the ICEBI was held in the United States. As in the last three conferences (Graz 2007, Gdansk 2004 and Oslo 2001) the ICEBI was combined with the Conference on Biomedical Applications of EIT - a mutually beneficial approach for those interested in the biophysics of tissue electrical properties and those developing imaging methods and measurement systems based thereon. This year's conference was particularly notable for the many papers presented on hybrid and emerging imaging techniques such as Electric Property Tomography (EPT), Magneto Acoustic Tomography using Magnetic Induction (MAT-MI) and Magnetic Resonance Electrical Impedance Tomography (MREIT); sessions on Cell Scale Impedance, Cardiac Impedance and Imaging Neural Activity. About 180 scientists from all over the world attended, including keynote speakers on topics of fundamental electromagnetic principles (Jaakko Malmivuo), Electrical Source and Impedance Imaging (Bin He), Bioimpedance applications in Nephrology, (Nathan Levin), and Lung EIT (Gerhard Wolf). The papers in this volume are peer-reviewed four-page works selected from over 150 presented in oral and poster sessions at the conference. The complete program is available from the conference website.

  7. COAL Conference Poster

    OpenAIRE

    Brown, Taylor Alexander; McGibbney, Lewis John

    2017-01-01

    COAL Conference Poster This archive contains the COAL conference poster for the AGU Fall Meeting 2017 by Taylor Alexander Brown. The Inkscape SVG source is available at https://github.com/capstone-coal/coal-conference-poster/ under the Creative Commons Attribution-ShareAlike 4.0 International license.

  8. Reflections on "Real-World" Community Psychology

    Science.gov (United States)

    Wolff, Tom; Swift, Carolyn

    2008-01-01

    Reflections on the history of real-world (applied) community psychologists trace their participation in the field's official guild, the Society for Community Research and Action (SCRA), beginning with the Swampscott Conference in 1965 through the current date. Four benchmarks are examined. The issues these real-world psychologists bring to the…

  9. Young People's Perception of Violence on the Screen: A Joint Project of UNESCO, the World Organization of the Scout Movement, and Utrecht University: Summary Report Presented to the General Conference of UNESCO, Paris, 1997.

    Science.gov (United States)

    Groebel, Jo

    1998-01-01

    A survey of 5000 12-year olds in 23 countries around the world was conducted to analyze the impact of media violence on children's lives in different cultures. This article presents a summary of findings to be published in full. Highlights media use, individual anxiety and role models, violence in the actual environment, and the relationship…

  10. Comparison of pharmaceutical formulations: ATR-FTIR spectroscopic imaging to study drug-carrier interactions.

    Science.gov (United States)

    Ewing, Andrew V; Biggart, Gordon D; Hale, Carwyn R; Clarke, Graham S; Kazarian, Sergei G

    2015-11-10

    Attenuated total reflection (ATR) Fourier transform infrared (FTIR) spectroscopic imaging has been used in combination with UV detection to study the release of a model poorly water-soluble drug, indomethacin, when formulated with selected drug carriers. Firstly, formulations of indomethacin and nicotinamide in varying weight ratios were studied since novel tablet dosage forms containing multi-drugs are of industrial interest. The in situ spectroscopic imaging measurements of the dissolving tablets showed that as the loading of indomethacin was increased, the rate of drug release changed from one that expressed first-order drug release to one which showed zero-order drug release. Two drug release mechanisms have been identified from the recorded spectroscopic images and UV dissolution profiles. To further validate these mechanisms, specific formulations containing the model drug and two other excipients, urea and mannitol, were studied. The formulations with urea showed similar first-order release, indicative of the drug-carrier interactions. Whereas, the indomethacin/mannitol formulations showed a zero-order release curve explained by disintegration of the tablet. ATR-FTIR spectroscopic imaging provided highly chemically specific information as well as the spatial distribution of the components during the dissolution process which has demonstrated the potential of this combined analytical setup to determine the mechanisms of drug release. Copyright © 2015 Elsevier B.V. All rights reserved.

  11. Independent Review of AFC 2A, 2B, and 2E ATR Irradiation Tests

    Energy Technology Data Exchange (ETDEWEB)

    M. Cappiello; R. Hobbins; K. Penny; L. Walters

    2014-01-01

    As part of the Department of Energy Advanced Fuel Cycle program, a series of fuels development irradiation tests have been performed in the Advanced Test Reactor (ATR) at the Idaho National Laboratory. These tests are providing excellent data for advanced fuels development. The program is focused on the transmutation of higher actinides which best can be accomplished in a sodium-cooled fast reactor. Because a fast test reactor is no longer available in the US, a special test vehicle is used to achieve near-prototypic fast reactor conditions (neutron spectra and temperature) for use in ATR (a water-cooled thermal reactor). As part of the testing program, there were many successful tests of advanced fuels including metals and ceramics. Recently however, there have been three experimental campaigns using metal fuels that experienced failure during irradiation. At the request of the program, an independent review committee was convened to review the post-test analyses performed by the fuels development team, to assess the conclusions of the team for the cause of the failures, to assess the adequacy and completeness of the analyses, to identify issues that were missed, and to make recommendations for improvements in the design and operation of future tests. Although there is some difference of opinion, the review committee largely agreed with the conclusions of the fuel development team regarding the cause of the failures. For the most part, the analyses that support the conclusions are sufficient.

  12. In vivo interstitial glucose characterization and monitoring in the skin by ATR-FTIR spectroscopy

    Science.gov (United States)

    Skrebova Eikje, Natalja

    2011-03-01

    Successful development of real-time non-invasive glucose monitoring would represent a major advancement not only in the treatment and management of patients with diabetes mellitus and carbohydrate metabolism disorders, but also for understanding in those biochemical, metabolic and (patho-)physiological processes of glucose at the molecular level in vivo. Here, ATR-FTIR spectroscopy technique has been challenged not only for in vivo measurement of interstitial glucose levels, but also for their non-invasive molecular qualitative and quantitative comparative characterization in the skin tissue. The results, based on calculated mean values of determined 5 glucose-specific peaks in the glucose-related 1000-1160 cm-1 region, showed intra- and inter-subject differences in interstitial glucose activity levels with their changes at different times and doses of OGTT, while raising questions about the relationships between interstitial and blood glucose levels. In conclusion, the introduction of ATR-FTIR spectroscopy technique has opened up an access to the interstitial fluid space in the skin tissue for interstitial glucose characterization and monitoring in vivo. Though interstitial versus blood glucose monitoring has different characteristics, it can be argued that accurate and precise measurements of interstitial glucose levels may be more important clinically.

  13. Rapid detection of melamine adulteration in dairy milk by SB-ATR-Fourier transform infrared spectroscopy.

    Science.gov (United States)

    Jawaid, Sana; Talpur, Farah N; Sherazi, S T H; Nizamani, Shafi M; Khaskheli, Abid A

    2013-12-01

    Melamine is a nitrogenous chemical substance used principally as a starting material for the manufacture of synthetic resins. Due to its very high proportion of nitrogen melamine has been added illegitimately to foods and feeds to increase the measured protein content, which determines the value of the product. These issues prompted private as well as governmental laboratories to develop methods for the analysis of melamine in a wide variety of food products and ingredients. Owing to this fact present study is aimed to use single bounce attenuated total reflectance (SB-ATR) Fourier transform infrared spectroscopy (FTIR) method as an effective rapid tool for the detection and quantification of melamine in milk (liquid and powder). Partial least-squares (PLS) models were established for correlating spectral data to melamine concentration with R(2)>0.99, and RMSEC 0.370. Linear calibration curves were obtained over the calibration range of 25-0.0625%. The LOD and LOQ of the method was 0.00025% (2.5 ppm) and 0.0015% (15 ppm) respectively. Proposed SB-ATR-FTIR method requires little or no sample preparation with an assay time of 1-2 min. Copyright © 2013. Published by Elsevier Ltd.

  14. Analytical characterization of polymers used in conservation and restoration by ATR-FTIR spectroscopy.

    Science.gov (United States)

    Chércoles Asensio, Ruth; San Andrés Moya, Margarita; de la Roja, José Manuel; Gómez, Marisa

    2009-12-01

    In the last few decades many new polymers have been synthesized that are now being used in cultural heritage conservation. The physical and chemical properties and the long-term behaviors of these new polymers are determined by the chemical composition of the starting materials used in their synthesis along with the nature of the substances added to facilitate their production. The practical applications of these polymers depend on their composition and form (foam, film, sheets, pressure-sensitive adhesives, heat-seal adhesives, etc.). Some materials are used in restoration works and others for the exhibition, storage and transport of works of art. In all cases, it is absolutely necessary to know their compositions. Furthermore, many different materials that are manufactured for other objectives are also used for conservation and restoration. The technical information about the materials provided by the manufacturer is usually incomplete, so it is necessary to analytically characterize such materials. FTIR spectrometry is widely used for polymer identification, and, more recently, ATR-FTIR has been shown to give excellent results. This paper reports the ATR-FTIR analysis of samples of polymeric materials used in the conservation of artworks. These samples were examined directly in the solid material without sample preparation.

  15. Analysis code for large rupture accidents in ATR. SENHOR/FLOOD/HEATUP

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-08-01

    In the evaluation of thermo-hydraulic transient change, the behavior of core reflooding and the transient change of fuel temperature in the events which are classified in large rupture accidents of reactor coolant loss, that is the safety evaluation event of the ATR, the analysis codes for thermo-hydraulic transient change at the time of large rupture SENHOR, for core reflooding characteristics FLOOD and for fuel temperature HEATUP are used, respectively. The analysis code system for loss of coolant accident comprises the analysis code for thermo-hydraulic transient change at the time of medium and small ruptures LOTRAC in addition to the above three codes. Based on the changes with time lapse of reactor thermal output and steam drum pressure obtained by the SENHOR, average reflooding rate is analyzed by the FLOOD, and the time of starting the turnaround of fuel cladding tube temperature and the heat transfer rate after the turnaround are determined. Based on these data, the detailed temperature change of fuel elements is analyzed by the HEATUP, and the highest temperature and the amount of oxidation of fuel cladding tubes are determined. The SENHOR code, the FLOOD code and the HEATUP code and various models for these codes are explained. The example of evaluation and the sensitivity analysis of the ATR plant are reported in the Appendix. (K.I.)

  16. New particle formation events measured on board the ATR-42 aircraft during the EUCAARI campaign

    Directory of Open Access Journals (Sweden)

    S. Crumeyrolle

    2010-07-01

    Full Text Available Aerosol properties were studied during an intensive airborne measurement campaign that took place at Rotterdam in Netherlands in May 2008 within the framework of the European Aerosol Cloud Climate and Air Quality Interactions project (EUCAARI. The objective of this study is to illustrate seven events of new particle formation (NPF observed with two Condensation Particle Counters (CPCs operated on board the ATR-42 research aircraft in airsectors around Rotterdam, and to provide information on the spatial extent of the new particle formation phenomenon based on 1-s resolution measurements of ultra-fine particle (in the size range 3–10 nm diameter, denoted N3-10 hereafter concentrations. The results show that particle production occurred under the influence of different air mass origins, at different day times and over the North Sea as well as over the continent. The number concentration of freshly nucleated particles (N3-10 varied between 5000 and 100 000 cm−3 within the boundary layer (BL. Furthermore the vertical extension for all nucleation events observed on the ATR-42 never exceeded the upper limit of the BL. The horizontal extent of N3-10 could not be delimited due to inflexible flight plans which could not be modified to accommodate real-time results. However, the NPF events were observed over geographically large areas; typically the horizontal extension was about 100 km and larger.

  17. Centromeric DNA replication reconstitution reveals DNA loops and ATR checkpoint suppression.

    Science.gov (United States)

    Aze, Antoine; Sannino, Vincenzo; Soffientini, Paolo; Bachi, Angela; Costanzo, Vincenzo

    2016-06-01

    Half of the human genome is made up of repetitive DNA. However, mechanisms underlying replication of chromosome regions containing repetitive DNA are poorly understood. We reconstituted replication of defined human chromosome segments using bacterial artificial chromosomes in Xenopus laevis egg extract. Using this approach we characterized the chromatin assembly and replication dynamics of centromeric alpha-satellite DNA. Proteomic analysis of centromeric chromatin revealed replication-dependent enrichment of a network of DNA repair factors including the MSH2-6 complex, which was required for efficient centromeric DNA replication. However, contrary to expectations, the ATR-dependent checkpoint monitoring DNA replication fork arrest could not be activated on highly repetitive DNA due to the inability of the single-stranded DNA binding protein RPA to accumulate on chromatin. Electron microscopy of centromeric DNA and supercoil mapping revealed the presence of topoisomerase I-dependent DNA loops embedded in a protein matrix enriched for SMC2-4 proteins. This arrangement suppressed ATR signalling by preventing RPA hyper-loading, facilitating replication of centromeric DNA. These findings have important implications for our understanding of repetitive DNA metabolism and centromere organization under normal and stressful conditions.

  18. Focusing, imaging, and ATR for the Gotcha 2008 wide angle SAR collection

    Science.gov (United States)

    Gianelli, Christopher D.; Xu, Luzhou

    2013-05-01

    The following work discusses IAA's approach to tackling the wide angle, circular spotlight, synthetic aperture radar (SAR) problem from the 2008 Gotcha wide angle SAR data set, which is publicly released, with unlimited distribution. This data set comes with a MATLAB image formation routine and attendant graphical user inter- face (GUI). We begin by introducing a simple approach to focusing the collected phase history data that utilizes point targets (quadrahedral targets) present in the scene. Two SAR imaging algorithms are then presented, namely, the data-independent backprojection (BP) algorithm and the data-adaptive sparse learning via itera- tive minimization (SLIM) algorithm. These imaging approaches are compared using the 2008 Gotcha wide angle SAR data to perform both a clutter discrimination experiment, as well as an automatic target recognition (ATR) experiment. The ATR system is composed of a target pose and target center estimation preprocessing system, and includes a novel target feature for the final classification stage. Empirical results obtained by applying the focusing approach and imaging algorithms to the 2008 Gotcha wide angle SAR data set are presented and described. The results presented highlight the benefit of applying the SLIM algorithm over its data-independent counterpart, as well as the utility of the novel target feature.

  19. Mebendazole crystal forms in tablet formulations. An ATR-FTIR/chemometrics approach to polymorph assignment.

    Science.gov (United States)

    Calvo, Natalia L; Kaufman, Teodoro S; Maggio, Rubén M

    2016-04-15

    Structural polymorphism of active pharmaceutical ingredients (API) is a relevant concern for the modern pharmaceutical industry, since different polymorphic forms may display dissimilar properties, critically affecting the performance of the corresponding drug products. Mebendazole (MEB) is a widely used broad spectrum anthelmintic drug of the benzimidazole class, which exhibits structural polymorphism (Forms A-C). Form C, which displays the best pharmaceutical profile, is the recommended one for clinical use. The polymorphs of MEB were prepared and characterized by spectroscopic, calorimetric and microscopic means. The polymorphs were employed to develop a suitable chemometrics-assisted sample display model based on the first two principal components of their ATR-FTIR spectra in the 4000-600 cm(-1) region. The model was internally and externally validated employing the leave-one-out procedure and an external validation set, respectively. Its suitability for revealing the polymorphic identity of MEB in tablets was successfully assessed analyzing commercial tablets under different physical forms (whole, powdered, dried, sieved and aged). It was concluded that the ATR-FTIR/PCA (principal component analysis) association is a fast, efficient and non-destructive technique for assigning the solid-state forms of MEB in its drug products, with minimum sample pre-treatment. Copyright © 2016 Elsevier B.V. All rights reserved.

  20. In-column ATR-FTIR spectroscopy to monitor affinity chromatography purification of monoclonal antibodies

    Science.gov (United States)

    Boulet-Audet, Maxime; Kazarian, Sergei G.; Byrne, Bernadette

    2016-07-01

    In recent years many monoclonal antibodies (mAb) have entered the biotherapeutics market, offering new treatments for chronic and life-threatening diseases. Protein A resin captures monoclonal antibody (mAb) effectively, but the binding capacity decays over repeated purification cycles. On an industrial scale, replacing fouled Protein A affinity chromatography resin accounts for a large proportion of the raw material cost. Cleaning-in-place (CIP) procedures were developed to extend Protein A resin lifespan, but chromatograms cannot reliably quantify any remaining contaminants over repeated cycles. To study resin fouling in situ, we coupled affinity chromatography and Fourier transform infrared (FTIR) spectroscopy for the first time, by embedding an attenuated total reflection (ATR) sensor inside a micro-scale column while measuring the UV 280 nm and conductivity. Our approach quantified the in-column protein concentration in the resin bed and determined protein conformation. Our results show that Protein A ligand leached during CIP. We also found that host cell proteins bound to the Protein A resin even more strongly than mAbs and that typical CIP conditions do not remove all fouling contaminants. The insights derived from in-column ATR-FTIR spectroscopic monitoring could contribute to mAb purification quality assurance as well as guide the development of more effective CIP conditions to optimise resin lifespan.

  1. ATR-IR study of skin components: Lipids, proteins and water. Part I: Temperature effect

    Science.gov (United States)

    Olsztyńska-Janus, S.; Pietruszka, A.; Kiełbowicz, Z.; Czarnecki, M. A.

    2018-01-01

    In this work we report the studies of the effect of temperature on skin components, such as lipids, proteins and water. Modifications of lipids structure induced by increasing temperature (from 20 to 90 °C) have been studied using ATR-IR (Attenuated Total Reflectance Infrared) spectroscopy, which is a powerful tool for characterization of the molecular structure and properties of tissues, such as skin. Due to the small depth of penetration (0.6-5.6 μm), ATR-IR spectroscopy probes only the outermost layer of the skin, i.e. the stratum corneum (SC). The assignment of main spectral features of skin components allows for the determination of phase transitions from the temperature dependencies of band intensities [e.g. νas(CH2) and νs(CH2)]. The phase transitions were determined by using two methods: the first one was based on the first derivative of the Boltzmann function and the second one employed tangent lines of sigmoidal, aforementioned dependencies. The phase transitions in lipids were correlated with modifications of the structure of water and proteins.

  2. Classification of Edible Oils Based on ATR-FTIR Spectral Information During a Long Heating Treatment.

    Science.gov (United States)

    Mahboubifar, Marjan; Hemmateenejad, Bahram; Yousefinejad, Saeed

    2017-03-01

    Identification of oil type and its QC are important concerns in food control laboratories. Classifying edible oils that have not been used (i.e., unheated) with the aid of vibrational spectroscopy has previously been reported. However, the classification of used (i.e., heat-treated) oils needs special attention. The effect of long heating times on the classification of four kinds of edible oils (canola, corn, frying, and sunflower) based on attenuated total reflectance (ATR)-FTIR spectra was surveyed. The sampling was done on the oils during a 36 h heating process (at 170°C). The ATR-FTIR spectra of the samples were collected in the range of 4000-550 cm-1. Interval extended canonical variates analysis (ECVA), as a variable selection and classification tool, was used to determine the best intervals during the heating procedure for classification. Principal component analysis discriminate analysis, partial least-squares discriminate analysis, and ECVA were performed on the selected intervals and on the total heating time. The effect of autoscaling and mean-centering, as data preprocessing methods, was also investigated. The ECVA method resulted in the best performances for classification, with a 94% cross-validated nonerror rate (one misclassification) for the heating process times of 24-27 and 33-36 h.

  3. Facilitating Learning at Conferences

    DEFF Research Database (Denmark)

    Ravn, Ib; Elsborg, Steen

    2011-01-01

    and facilitate a variety of simple learning techniques at thirty one- and two-day conferences of up to 300 participants each. We present ten of these techniques and data evaluating them. We conclude that if conference organizers allocate a fraction of the total conference time to facilitated processes......The typical conference consists of a series of PowerPoint presentations that tend to render participants passive. Students of learning have long abandoned the transfer model that underlies such one-way communication. We propose an al-ternative theory of conferences that sees them as a forum...

  4. The learning conference

    DEFF Research Database (Denmark)

    Ravn, Ib

    2007-01-01

    Purpose: To call attention to the fact that conferences for professionals rely on massive one-way communication and hence produce little learning for delegates. To introduce an alternative, the ?learning conference,? that involves delegates in fun and productive learning processes. Design....../methodology/approach: A typical full-day conference is analyzed. It has six hours of podium talk and twenty-five minutes for delegates to become involved. What model of learning can possibly lie behind this? The transfer model, which assumes learners to be empty vessels. An alternative view is that conference delegates...... are active professionals in search of inspiration, and they also want to share knowledge with their peers at the conference. A theory of the conference as a forum for mutual inspiration and human co-flourishing is proposed, as are four design principles for a learning conference: 1. Presentations must...

  5. [Real-world evidence.

    Science.gov (United States)

    De Fiore, Luca; Addis, Antonio

    2017-12-01

    Real-world evidence is among the most frequently discussed issues at professional medical conferences and meetings. It refers to data and information derived from sources such as electronic health records, disease or product registries, and observational research. Looking for an accelerated approval of new pharmaceutical products and devices, real-world evidence is considered a useful tool to confirm data collected for regulatory purposes. Anyway, randomised controlled trials still remain the gold standard of clinical research, in order to minimize bias and to evaluate the effectiveness of a clinical intervention. A pragmatic approach and quasi-randomised trials to shorten length and costs of the studies can be considered. The problem lies with the quality of data rather than with the context in which evidence is gathered.

  6. 5th European Rheology Conference

    CERN Document Server

    1998-01-01

    Global sustainable development of the world economy requires better understanding and utilization of natural recourses. In this endeavor rheology has an indispensable role. The Rheology Conferences are therefore always an important event for science and technology. The Fifth European Rheology Conference, held from September 6 to 11 in the Portoro-z, Slovenia, will be the first AlI-European rheology meeting after the formal constitution of the European Society ofRheology. As such it will be a special historical event. At this meeting the European Society of Rheology will introduce the Weissenberg Medal, to be bestowed every four years to an individual for hislhers contribution to the field of Rheology. The recipient ofthe first award will be professor G. Marrucci ofthe Universita degli Studi di Napoli, Italy. Two mini Symposia will be part of the Conference. The first, on Industrial Rheology, will commemorate the late professor G. Astarita. The second will honor the eightieth birthday of professor N.W. Tschoeg...

  7. 5th European Turbulence Conference

    CERN Document Server

    1995-01-01

    Under the auspices of the Euromech Committee, the Fifth European Turbulence Conference was held in Siena on 5-8 July 1994. Following the previous ETC meeting in Lyon (1986), Berlin (1988), Stockholm (1990) and Delft (1992), the Fifth ETC was aimed at providing a review of the fundamental aspects of turbulence from a theoretical, numerical and experimental point of view. In the magnificent town of Siena, more than 250 scientists from all over the world, spent four days discussing new ideas on turbulence. As a research worker in the field of turbulence, I must say that the works presented at the Conference, on which this book is based, covered almost all areas in this field. I also think that this book provides a major opportunity to have a complete overview of the most recent research works. I am extremely grateful to Prof. C. Cercignani, Dr. M. Loffredo, and Prof. R. Piva who, as members of the local organizing committee, share the success of the Conference. I also want to thank Mrs. Liu' Catena, for her inva...

  8. The ‘diverse, dynamic new world of global tobacco control’? An analysis of participation in the Conference of the Parties to the WHO Framework Convention on Tobacco Control

    Science.gov (United States)

    Plotnikova, Evgeniya; Hill, Sarah E; Collin, Jeff

    2014-01-01

    Introduction The increasingly inequitable impacts of tobacco use highlight the importance of ensuring developing countries’ ongoing participation in global tobacco control. The WHO Framework Convention on Tobacco Control (FCTC) has been widely regarded as reflecting the high engagement and effective influence of developing countries. Methods We examined participation in FCTC governance based on records from the first four meetings of the Conference of the Parties (COP), comparing representation and delegate diversity across income levels and WHO regions. Results While attendance at the COP sessions is high, there are substantial disparities in the relative representation of different income levels and regions, with lower middle and low income countries contributing only 18% and 10% of total meeting delegates, respectively. In regional terms, Europe provided the single largest share of delegates at all except the Durban (2008) meeting. Thirty-nine percent of low income countries and 27% of those from Africa were only ever represented by a single person delegation compared with 10% for high income countries and 11% for Europe. Rotation of the COP meeting location outside of Europe is associated with better representation of other regions and a stronger presence of delegates from national ministries of health and focal points for tobacco control. Conclusions Developing countries face particular barriers to participating in the COP process, and their engagement in global tobacco control is likely to diminish in the absence of specific measures to support their effective participation. PMID:23152101

  9. Identification and classification of textile fibres using ATR-FT-IR spectroscopy with chemometric methods.

    Science.gov (United States)

    Peets, Pilleriin; Leito, Ivo; Pelt, Jaan; Vahur, Signe

    2017-02-15

    The possibility of classification of single- and two-component textile materials using ATR-FT-IR spectra and chemometric methods, principal component analysis (PCA) and discriminant analysis, was assessed. Altogether 89 textile samples belonging to 26 different types (11 one- and 15 two-component textiles) were investigated. It was found that PCA classification using only two or three principal components (PCs) enables identifying different one- and two-component textiles, although with two important limitations: it was not always possible to distinguish between the cellulose-based fibres (cotton, linen and in some cases viscose) and it was only partly possible to distinguish between silk and wool. The statistical discriminant analysis can use as many PCs as there are sample classes and due to that can discriminate between single-component fibres, including viscose from linen and cotton as well as silk from wool. Besides that, in both of these cases, involving optical microscopy as an additional technique enabled unequivocal identification of the fibres. The possibilities of semi-quantitative analysis of mixed fibres (cotton-polyester, wool-polyester and wool-polyamide) with PCA were investigated and it was found that approximate quantitative composition is obtainable if for the mixed fibre sample a number of spectra are averaged in order to minimize the effect of structural inhomogeneity. For approximate content determination 25 spectra of selected two-component samples were registered for calibration and the averaged spectrum for each sample was computed. Due to the structural inhomogeneity of mixed textiles, obtaining accurate quantitative composition from real samples is not possible with ATR-FT-IR. The main problems with ATR-FT-IR-PCA classification are (1) difficulties in getting high quality spectra from some textiles (e.g. polyacrylic), (2) inhomogeneity of the textile fibres in the case of two-component fibres and (3) intrinsic similarity between the

  10. Assessment of XM-19 as a Substitute for AISI 348 in ATR Service

    Energy Technology Data Exchange (ETDEWEB)

    F. A. Garner; L. R. Greenwood; R. E. Mizia; C. R. Tyler

    2007-11-01

    It has been proposed that XM-19 alloy be considered as a possible replacement steel for AISI 348 in the construction of Advanced Test Reactor (ATR) capsules. AISI 348 works well, but is currently very difficult to obtain commercially. The superior and desirable mechanical properties of XM-19 alloy have been proven in non-nuclear applications, but no data are available regarding its use in radiation environments. While most 300 series alloys will meet the conditions required in ATR , it cannot be confidently assumed that XM-19 can be substituted without prior qualification in a radiation test. Compared to AISI 348, XM-19 will have an enhanced tendency for phase instabilities due to its higher levels of Ni and, especially, Si. However, transmutation of important elemental components in the highly thermalized ATR spectrum may have a very pronounced effect on its performance during irradiation. Not only will strong transmutation of Mn to Fe reduce the ductility and strength advantages provided by the higher initial Mn content of XM-19, but the extensive loss of Mn will also release from solution much of the N upon which the higher strength of XM-19 depends. In addition, the combined influence of transmutation and Inverse Kirkendall processes may lead to gas-bubble-covered grain boundaries, producing a very fragile alloy after significant irradiation has accumulated. At present, there are no radiation data available to substantiate this possible scenario. An alternate proposal is therefore advanced. Since the response of AISI 348 and 347 to radiation are expected to be relatively indistinguishable, the AISI 347 might serve as an acceptable replacement. While AISI 348 is usually chosen for nuclear service in order to reduce the overall radioactivity arising from relatively small amounts of highly transmutable elements such as cobalt, these elements have very little effect on the radiation performance of the steel. In the proposed application, however, the activity

  11. 2nd International Conference on Intelligent Computing and Applications

    CERN Document Server

    Dash, Subhransu; Das, Swagatam; Panigrahi, Bijaya

    2017-01-01

    Second International Conference on Intelligent Computing and Applications was the annual research conference aimed to bring together researchers around the world to exchange research results and address open issues in all aspects of Intelligent Computing and Applications. The main objective of the second edition of the conference for the scientists, scholars, engineers and students from the academia and the industry is to present ongoing research activities and hence to foster research relations between the Universities and the Industry. The theme of the conference unified the picture of contemporary intelligent computing techniques as an integral concept that highlights the trends in computational intelligence and bridges theoretical research concepts with applications. The conference covered vital issues ranging from intelligent computing, soft computing, and communication to machine learning, industrial automation, process technology and robotics. This conference also provided variety of opportunities for ...

  12. An essential function for the ATR-activation-domain (AAD of TopBP1 in mouse development and cellular senescence.

    Directory of Open Access Journals (Sweden)

    Zhong-Wei Zhou

    Full Text Available ATR activation is dependent on temporal and spatial interactions with partner proteins. In the budding yeast model, three proteins - Dpb11(TopBP1, Ddc1(Rad9 and Dna2 - all interact with and activate Mec1(ATR. Each contains an ATR activation domain (ADD that interacts directly with the Mec1(ATR:Ddc2(ATRIP complex. Any of the Dpb11(TopBP1, Ddc1(Rad9 or Dna2 ADDs is sufficient to activate Mec1(ATR in vitro. All three can also independently activate Mec1(ATR in vivo: the checkpoint is lost only when all three AADs are absent. In metazoans, only TopBP1 has been identified as a direct ATR activator. Depletion-replacement approaches suggest the TopBP1-AAD is both sufficient and necessary for ATR activation. The physiological function of the TopBP1 AAD is, however, unknown. We created a knock-in point mutation (W1147R that ablates mouse TopBP1-AAD function. TopBP1-W1147R is early embryonic lethal. To analyse TopBP1-W1147R cellular function in vivo, we silenced the wild type TopBP1 allele in heterozygous MEFs. AAD inactivation impaired cell proliferation, promoted premature senescence and compromised Chk1 signalling following UV irradiation. We also show enforced TopBP1 dimerization promotes ATR-dependent Chk1 phosphorylation. Our data suggest that, unlike the yeast models, the TopBP1-AAD is the major activator of ATR, sustaining cell proliferation and embryonic development.

  13. Superhabitable worlds.

    Science.gov (United States)

    Heller, René; Armstrong, John

    2014-01-01

    To be habitable, a world (planet or moon) does not need to be located in the stellar habitable zone (HZ), and worlds in the HZ are not necessarily habitable. Here, we illustrate how tidal heating can render terrestrial or icy worlds habitable beyond the stellar HZ. Scientists have developed a language that neglects the possible existence of worlds that offer more benign environments to life than Earth does. We call these objects "superhabitable" and discuss in which contexts this term could be used, that is to say, which worlds tend to be more habitable than Earth. In an appendix, we show why the principle of mediocracy cannot be used to logically explain why Earth should be a particularly habitable planet or why other inhabited worlds should be Earth-like. Superhabitable worlds must be considered for future follow-up observations of signs of extraterrestrial life. Considering a range of physical effects, we conclude that they will tend to be slightly older and more massive than Earth and that their host stars will likely be K dwarfs. This makes Alpha Centauri B, which is a member of the closest stellar system to the Sun and is supposed to host an Earth-mass planet, an ideal target for searches for a superhabitable world.

  14. 11th International Conference on Atmospheric Electricity

    Science.gov (United States)

    Christian, H. J. (Compiler)

    1999-01-01

    This document contains the proceedings from the 11th International Conference on Atmospheric Electricity (ICAE 99), held June 7-11, 1999. This conference was attended by scientists and researchers from around the world. The subjects covered included natural and artificially initiated lightning, lightning in the middle and upper atmosphere (sprites and jets), lightning protection and safety, lightning detection techniques (ground, airborne, and space-based), storm physics, electric fields near and within thunderstorms, storm electrification, atmospheric ions and chemistry, shumann resonances, satellite observations of lightning, global electrical processes, fair weather electricity, and instrumentation.

  15. International Conference on Advanced Computing for Innovation

    CERN Document Server

    Angelova, Galia; Agre, Gennady

    2016-01-01

    This volume is a selected collection of papers presented and discussed at the International Conference “Advanced Computing for Innovation (AComIn 2015)”. The Conference was held at 10th -11th of November, 2015 in Sofia, Bulgaria and was aimed at providing a forum for international scientific exchange between Central/Eastern Europe and the rest of the world on several fundamental topics of computational intelligence. The papers report innovative approaches and solutions in hot topics of computational intelligence – advanced computing, language and semantic technologies, signal and image processing, as well as optimization and intelligent control.

  16. Seventh Scandinavian Conference on Artificial Intelligence

    DEFF Research Database (Denmark)

    Lund, Henrik Hautop; Mayoh, Brian Henry; Perram, John

    2001-01-01

    The book covers the seventh Scandinavian Conference on Artificial Intelligence, held at the Maersk Mc-Kinney Moller Institute for Production Technology at the University of Southern Denmark during the period 20-21 February, 2001. It continues the tradition established by SCAI of being one...... of the most important regional AI conferences in Europe, attracting high quality submissions from Scandinavia and the rest of the world, including the Baltic countries. The contents include robotics, sensor/motor intelligence, evolutionary robotics, behaviour-based systems, multi-agent systems, applications...

  17. In Situ ATR-FTIR Study on the Selective Photo-oxidation of Cyclohexane over Anatase TiO2

    NARCIS (Netherlands)

    Almeida, A.; Moulijn, J.A.; Mul, Guido

    2008-01-01

    Anatase-catalyzed photo-oxidation of cyclohexane was analyzed by in situ ATR-FTIR spectroscopy. A set of seven UV-LEDs (375 nm), with a photon flux of 9 × 10-9 Einstein·cm-2·s-1 (at the catalyst surface) was used to initiate the photoreaction. Surface-adsorbed cyclohexanone and water are the primary

  18. Using paint to investigate fires: an ATR-IR study of the degradation of paint samples upon heating.

    Science.gov (United States)

    Roberts, Kelly; Almond, Matthew J; Bond, John W

    2013-03-01

    Fire investigation is a challenging area for the forensic investigator. The aim of this work was to use spectral changes to paint samples to estimate the temperatures to which a paint has been heated. Five paint samples (one clay paint, two car paints, one metallic paint, and one matt emulsion) have been fully characterized by a combination of attenuated total reflectance Fourier transform infrared (ATR-IR), Raman, X-ray fluorescence spectroscopy and powder X-ray diffraction. The thermal decomposition of these paints has been investigated by means of ATR-IR and thermal gravimetric analysis. Clear temperature markers are observed in the ATR-IR spectra namely: loss of ν(C = O) band, >300°C; appearance of water bands on cooling, >500°C; alterations to ν(Si-O) bands due to dehydration of silicate clays, >700°C; diminution of ν(CO3 ) and δ(CO3 ) modes of CaCO3 , >950°C. We suggest the possible use of portable ATR-IR for nondestructive, in situ analysis of paints. © 2012 American Academy of Forensic Sciences.

  19. Attenuated Total Reflection Fourier Transform Infrared (ATR-FTIR) in the discrimination of normal and oral cancer blood plasma

    Science.gov (United States)

    Pachaiappan, Rekha; Prakasarao, Aruna; Singaravelu, Ganesan

    2017-02-01

    Oral cancer is the most frequent type of cancer that occurs with 75000 to 80000 new cases reported every year in India. The carcinogens from tobacco and related products are the main cause for the oral cancer. ATR-FTIR method is label free, fast and cost-effective diagnostic method would allow for rapid diagnostic results in earlier stages by the minimal chemical changes occur in the biological metabolites available in the blood plasma. The present study reports the use of ATR-FTIR data with advanced statistical model (LDA-ANN) in the diagnosis of oral cancer from normal with better accuracy. The infrared spectra were acquired on ATR-FTIR Jasco spectrophotometer at 4 cm-1 resolution, 30 scans, in the 1800-900 cm-1 spectral range. Each sample had 5 spectra recorded from each blood plasma sample. The spectral data were routed through the multilayer perception of artificial neural network to evaluate for the statistical efficacy. Among the spectral data it was found that amide II (1486 cm-1) and lipid (1526 cm-1) affords about 90 % in the discrimination between groups using LDA. These preliminary results indicate that ATR-FTIR is useful to differentiate normal subject from oral cancer patients using blood plasma.

  20. Stability of indomethacin with relevance to the release from amorphous solid dispersions studied with ATR-FTIR spectroscopic imaging.

    Science.gov (United States)

    Ewing, Andrew V; Clarke, Graham S; Kazarian, Sergei G

    2014-08-18

    This work presents the use of attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopy and spectroscopic imaging to study the stability and dissolution behaviour of amorphous solid dispersions (ASDs). ASDs are employed to improve the bioavailability of drugs which are poorly soluble in aqueous solutions. Selecting the appropriate polymeric excipients for use in pharmaceutical tablets is crucial to control drug stability and subsequent release. In this study, indomethacin was used as a model poorly-aqueous soluble drug since the amorphous-form has improved dissolution properties over its crystalline forms. ASDs of indomethacin/polyethylene glycol (PEG) and indomethacin/hydroxypropyl methylcellulose (HPMC) in a 1:3 wt ratio were compared. Firstly, ATR-FTIR spectroscopy was employed to monitor the stability of indomethacin in the ASDs over 96 h. While the indomethacin/HPMC ASD showed the ability to maintain the amorphous indomethacin form for longer periods of time, ATR-FTIR spectra revealed that indomethacin in the drug/PEG ASD crystallised to the stable γ-form, via the α-form. Secondly, ATR-FTIR spectroscopic imaging was used to study the dissolution of ASD tablets in a phosphate buffer (pH 7.5). Crystallisation of amorphous indomethacin was characterised in the spectra collected during the dissolution of the indomethacin/PEG ASD which consequently hindered release into the surrounding solution. In contrast, release of amorphous indomethacin was more effective from HPMC. Copyright © 2014 Elsevier B.V. All rights reserved.

  1. UV-induced G2 checkpoint depends on p38 MAPK and minimal activation of ATR-Chk1 pathway

    NARCIS (Netherlands)

    D.O. Warmerdam (Daniël); E.K. Brinkman (Eva); J.A. Marteijn (Jurgen); R.H. Medema (Rene); R. Kanaar (Roland); V.A.J. Smits (Veronique)

    2013-01-01

    textabstractIn response to UV light, single-stranded DNA intermediates coated with replication protein A (RPA) are generated, which trigger the ATR-Chk1 checkpoint pathway. Recruitment and/or activation of several checkpoint proteins at the damaged sites is important for the subsequent cell cycle

  2. ATR-FTIR Spectroscopy Highlights the Problem of Distinguishing Between Exophiala dermatitidis and E. phaeomuriformis Using MALDI-TOF MS

    NARCIS (Netherlands)

    Ergin, C.; Gok, Y.; Baygu, Y.; Gumral, R.; Ozhak-Baysan, B.; Dogen, A.; Ogunc, D.; Ilkit, M.; Seyedmousavi, S.

    2016-01-01

    The present study compared two chemical-based methods, namely, matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry (MALDI-TOF MS) and attenuated total reflectance-Fourier transform infrared (ATR-FTIR) spectroscopy, to understand the misidentification of Exophiala

  3. Characterization of southern yellow pine bark layers by Attenuated Total Reflectance (ATR) and Fourier Transform Infrared (FT-IR) Spectroscopy

    Science.gov (United States)

    Thomas L. Eberhardt

    2009-01-01

    The outer bark (rhytidome) of the southern yellow pines is a complex structure comprised of alternating layers of obliterated phloem and periderm tissues, with the latter comprised of three layers, those being phellem, phellogen, and phelloderm. An attenuated total reflectance (ATR) sampling accessory, coupled with a Fourier transform infrared (FTIR) spectrometer,...

  4. Measured thermal and fast neutron fluence rates for ATF-1 holders during ATR cycle 158B/159A

    Energy Technology Data Exchange (ETDEWEB)

    Smith, Larry Don [Idaho National Lab. (INL), Idaho Falls, ID (United States); Miller, David Torbet [Idaho National Lab. (INL), Idaho Falls, ID (United States); Walker, Billy Justin [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2016-11-01

    This report contains the thermal (2200 m/s) and fast (E>1MeV) neutron fluence rate data for the ATF-1 holders located in core for ATR Cycle 158B/159A which were measured by the Radiation Measurements Laboratory (RML).

  5. Characterization of poly(L-lactide/Propylene glycol) based polyurethane films using ATR-FTIR spectroscopy

    Science.gov (United States)

    Manap, Siti Munirah; Ahmad, Azizan; Anuar, Farah Hannan

    2016-11-01

    A polyurethane films consisting of PLLA, PPG and PLLA-PPG were prepared using solution casting method. Three types of polyurethane were prepared: PPLA:PMDI, PPG:PMDI and PLLA-PPG:PMDI in the presence of polymeric diphenylmethane diisocyanate (PMDI) as the coupling agent and catalyst, Sn(Oct)2. The aim of this research was to improve the physicals properties of PLLA and PPG homopolymers through copolymerization between the two polymers. The homopolymers and polyurethane films were characterized using ATR-FTIR spectroscopy. Chemical reaction between PLLA, PPG and PMDI before and after the reaction were confirmed by observing the shifting of wavenumber for the carbonyl and ether group. Other than that, the additional band for N-H after the reaction indicated that the reaction was successful.

  6. Unidirectional excitation of graphene plasmon in attenuated total reflection (ATR) configuration

    Energy Technology Data Exchange (ETDEWEB)

    Dai, Wei [Hubei University of Education, Wuhan (China). School of Physics and Mechanical and Electrical Engineering; Wu, Yue-Chao [Nanyang Technological University, Singapore (Singapore). Div. of Physics and Applied Physics; Liu, Fang-Li [Maryland Univ., College Park, MD (United States). Joint Quantum Institute

    2016-08-01

    Graphene plasmon has been attracting interests from both theoretical and experimental research due to its gate tunability and potential applications in the terahertz frequency range. Here, we propose an effective scheme to unidirectionally excite the graphene plasmon by exploiting magneto-optical materials in the famous attenuated total reflection (ATR) configuration. We show that the graphene plasmon dispersion relation in such a device is asymmetric in different exciting directions, thus making it possible to couple the incident light unidirectionally to the propagating plasmon. The split of absorption spectrum of graphene clearly indicates that under a magnetic field for one single frequency, graphene plasmon can only be excited in one direction. The possible gate tunablity of excitation direction and the further application of the proposed scheme, such as optical isolator, also are discussed.

  7. Usage of FTIR-ATR as Non-Destructive Analysis of Selected Toxic Dyes

    Science.gov (United States)

    Bartošová, Alica; Blinová, Lenka; Sirotiak, Maroš; Michalíková, Anna

    2017-06-01

    The degradation of the environment which is due to the discharge of polluting wastewater from industrial sources poses a real problem in several countries. Textile industries use large volumes of water in their operations, discharging thus large volume of wastewater into the environment, most of which is untreated. The wastewater contains a variety of chemicals from various stages of process operations, including desizing, scouring, bleaching and dyeing. The main purpose of this paper is to introduce Infrared Spectrometry with Fourier transformation as a non-destructive method for study, identifation and rapid determination of selected representatives of cationic (Methylene Blue), azo (Congo Red, Eriochrome Black T) and nitroso (Naphthol Green B) dyes. In conjunction with the ATR technique, FTIR offers a reliable detection method of dyes without extraction by other dangerous substances. Spectral interpretation of dye spectra revealed valuable information about the identification and characterization of each group of dyes.

  8. International Cryocooler Conference

    CERN Document Server

    Cryocoolers 13

    2005-01-01

    This is the 13th volume in the conference series. Over the years the International Cryocoolers Conference has become the preeminent worldwide conference for the presentation of the latest developments and test experiences with cryocoolers. The typical applications of this technology include cooling space and terrestrial infrared focal plane arrays, space x-ray detectors, medical applications, and a growing number of high-temperature super-capacitor applications.

  9. Analysis of H2O in silicate glass using attenuated total reflectance (ATR) micro-FTIR spectroscopy

    Science.gov (United States)

    Lowenstern, Jacob B.; Pitcher, Bradley W.

    2013-01-01

    We present a calibration for attenuated total reflectance (ATR) micro-FTIR for analysis of H2O in hydrous glass. A Ge ATR accessory was used to measure evanescent wave absorption by H2O within hydrous rhyolite and other standards. Absorbance at 3450 cm−1 (representing total H2O or H2Ot) and 1630 cm−1 (molecular H2O or H2Om) showed high correlation with measured H2O in the glasses as determined by transmission FTIR spectroscopy and manometry. For rhyolite, wt%H2O=245(±9)×A3450-0.22(±0.03) and wt%H2Om=235(±11)×A1630-0.20(±0.03) where A3450 and A1630 represent the ATR absorption at the relevant infrared wavelengths. The calibration permits determination of volatiles in singly polished glass samples with spot size down to ~5 μm (for H2O-rich samples) and detection limits of ~0.1 wt% H2O. Basaltic, basaltic andesite and dacitic glasses of known H2O concentrations fall along a density-adjusted calibration, indicating that ATR is relatively insensitive to glass composition, at least for calc-alkaline glasses. The following equation allows quantification of H2O in silicate glasses that range in composition from basalt to rhyolite: wt%H2O=(ω×A3450/ρ)+b where ω = 550 ± 21, b = −0.19 ± 0.03, ρ = density, in g/cm3, and A3450 is the ATR absorbance at 3450 cm−1. The ATR micro-FTIR technique is less sensitive than transmission FTIR, but requires only a singly polished sample for quantitative results, thus minimizing time for sample preparation. Compared with specular reflectance, it is more sensitive and better suited for imaging of H2O variations in heterogeneous samples such as melt inclusions. One drawback is that the technique can damage fragile samples and we therefore recommend mounting of unknowns in epoxy prior to polishing. Our calibration should hold for any Ge ATR crystals with the same incident angle (31°). Use of a different crystal type or geometry would require measurement of several H2O-bearing standards to provide a crystal

  10. HPV 5 and 8 E6 abrogate ATR activity resulting in increased persistence of UVB induced DNA damage.

    Directory of Open Access Journals (Sweden)

    Nicholas A Wallace

    Full Text Available The role of the E6 oncoprotein from high-risk members of the α human papillomavirus genus in anogenital cancer has been well established. However, far less is known about the E6 protein from the β human papillomavirus genus (β-HPVs. Some β-HPVs potentially play a role in non-melanoma skin cancer development, although they are not required for tumor maintenance. Instead, they may act as a co-factor that enhances the carcinogenic potential of UV damage. Indeed, the E6 protein from certain β-HPVs (HPV 5 and 8 promotes the degradation of p300, a histone acetyl transferase involved in UV damage repair. Here, we show that the expression of HPV 5 and 8 E6 increases thymine dimer persistence as well as the likelihood of a UVB induced double strand break (DSB. Importantly, we provide a mechanism for the increased DNA damage by showing that both extended thymine dimer persistence as well as elevated DSB levels are dependent on the ability of HPV 8 E6 to promote p300 degradation. We further demonstrate that HPV 5 and 8 E6 expression reduces the mRNA and protein levels of ATR, a PI3 kinase family member that plays a key role in UV damage signaling, but that these levels remain unperturbed in cells expressing a mutated HPV 8 E6 incapable of promoting p300 degradation. We confirm that the degradation of p300 leads to a reduction in ATR protein levels, by showing that ATR levels rebound when a p300 mutant resistant to HPV 8 mediated degradation and HPV 8 E6 are co-transfected. Conversely, we show that ATR protein levels are reduced when p300 is targeted for degradation by siRNA. Moreover, we show the reduced ATR levels in HPV 5 and 8 E6 expressing cells results in delayed ATR activation and an attenuated ability of cells to phosphorylate, and as a result accumulate, p53 in response to UVB exposure, leading to significantly reduced cell cycle arrest. In conclusion, these data demonstrate that β-HPV E6 expression can enhance the carcinogenic potential of

  11. ATR technique, an appropriate method for determining the degree of conversion in dental giomers

    Science.gov (United States)

    Prejmerean, Cristina; Prodan, Doina; Vlassa, Mihaela; Streza, Mihaela; Buruiana, Tinca; Colceriu, Loredana; Prejmerean, Vasile; Cuc, Stanca; Moldovan, Marioara

    2016-12-01

    Dental light-curing giomers were developed to combine the favourable properties of diacrylic resin composites (DRCs) and glass-ionomer cements (GICs) in a single material and to eliminate their inherent drawbacks. Giomers are characterized by their aesthetic appearance, high mechanical properties, adhesion to dental tissues as well as fluoride release and recharge abilities. The qualities of the giomers are greatly influenced by the level of conversion of the component resins. Infrared spectroscopy is one of the most largely used techniques for the determination of the degree of conversion in resin-based dental materials. However different results were obtained due to the performances of the used methods. The present work presents the determination of conversion degree in a series of dental copolymers and their corresponding giomers using transmission Fourier transform infrared spectroscopy (FTIR) and an attenuated total reflection technique (ATR) technique, respectively, the main aim being the study of the influence of the materials composition and of the light curing modes upon the achieved conversion in the cured giomers. Beautifil II commercial giomer was used as a control. A halogen lamp and a diode-blue LED lamp were used for the curing of the materials. The results showed that the composition of the resins greatly influenced the conversion. The highest conversions (up to 79%) were obtained in the case of the experimental giomers which contained the experimental Bis-GMA urethane analogue, followed by the Beautifil II giomer (61%) and experimental giomers based on commercial Bis-GMA (up to 50%), respectively. The resins light-cured by using the diode-blue LED lamp presented slightly higher conversions than the resins cured by halogen lamp. The study demonstrates the possibility to evaluate easily and reproducibly the conversion in light-curing composite materials with complex chemical composition and structure, particularly in the case of giomers by using the

  12. Rapid detection of NBOME's and other NPS on blotter papers by direct ATR-FTIR spectrometry.

    Science.gov (United States)

    Coelho Neto, José

    2015-07-01

    Blotter paper is among the most common forms of consumption of new psychotropic substances (NPS), formerly referred as designer drugs. In many cases, users are misled to believe they are taking LSD when, in fact, they are taking newer and less known drugs like the NBOMEs or other substituted phenethylamines. We report our findings in quick testing of blotter papers for illicit substances like NBOMEs and other NPS by taking ATR-FTIR spectra directly from blotters seized on the streets, without any sample preparation. Both sides (front and back) of each blotter were tested. Collected data were analyzed by single- and multi-component spectral matching and submitted to chemometric discriminant analysis. Our results showed that, on 66.7% of the cases analyzed, seized blotters contained one or more types of NBOMEs, confirming the growing presence of this novel substances on the market. Matching IR signals were detected on both or just one side of the blotters and showed variable strength. Although no quantitative analysis was made, detection of these substances by the proposed approach serves as indication of variable and possibly higher dosages per blotter when compared to LSD, which showed to be below the detection limit of the applied method. Blotters containing a mescaline-like compound, later confirmed by GC-MS and LC-MS to be MAL (methallylescaline), a substance very similar to mescaline, were detected among the samples tested. Validity of direct ATR-FTIR testing was confirmed by checking the obtained results against independent GC-MS or LC-MS results for the same cases/samples. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  13. Cutaneous approach towards clinical and pathophysiological aspects of hyperglycemia by ATR FTIR spectroscopy

    Science.gov (United States)

    Eikje, Natalja Skrebova; Sota, Takayuki; Aizawa, Katsuo

    2007-07-01

    Attempts were made to non-invasively detect glucose-specific spectral signals in the skin by ATR-FTIR spectroscopy. In vivo spectra were collected from the inner wrists of healthy, prediabetes and diabetes subjects in the 750-4000 cm -1 region, with a closer assessment of the glucose-related region between 1000 and 1180 cm -1. Spectra in vivo showed glucose-specific peaks at 1030, 1080, 1118 and 1151 cm -1, as a variety of glucose solutions are found in vitro. Based on the differences of intensities at 1030 and 1118 cm -1 two spectral patterns were seen: I 1118 > I 1030 for a diabetes and I 1030> I 1118 for non-diabetes subjects. The peak at 1030 cm -1 was used to assess glucose concentrations in the skin due to its good correlation with glucose concentrations in vitro. Calculated mean values of the peak at 1030 cm -1 showed evidence of correlation with blood glucose levels when grouped as = 200 mg/dL, though there was no constant correlation between them when compared before/after OGTT or at the fasting/postprandial states. Absorbances at 1030 cm -1 were not only increased in a dose-dependent manner in a diabetes patient, but were also generally higher than in non-diabetes subjects at 30 min OGTT assessment. Also we could monitor absorbances at 1030 cm -1 and determine their changes in the skin tissue at different times of OGTT. We assume that our approach to in vivo measurement and monitoring of glucose concentrations at 1030 cm -1 may be one of the indicators to assess glucose activity level and its changes in the skin tissue, and has further implications in the study of clinical and pathophysiological aspects of hyperglycemia in diabetes and non-diabetes subjects by ATR-FTIR spectroscopy.

  14. Rapid classification and quantification of cocaine in seized powders with ATR-FTIR and chemometrics.

    Science.gov (United States)

    Eliaerts, Joy; Dardenne, Pierre; Meert, Natalie; Van Durme, Filip; Samyn, Nele; Janssens, Koen; De Wael, Karolien

    2017-10-01

    Traditionally, fast screening for the presence of cocaine in unknown powders is performed by means of colour tests. The major drawbacks of these tests are subjective colour evaluation depending on the operator ('50 shades of blue') and a lack of selectivity. An alternative fast screening technique is Fourier Transform InfraRed (FTIR) spectrometry. This technique provides spectra that are difficult to interpret without specialized expertise and shows a lack of sensitivity for the detection of cocaine in mixtures. To overcome these limitations, a portable FTIR spectrometer using Attenuated Total Reflectance (ATR) sampling was combined with a multivariate technique, called Support Vector Machines (SVM). Representative street drug powders (n = 482), seized during the period January 2013 to July 2015, and reference powders (n = 33) were used to build and validate a classification model (n = 515) and a quantification model (n = 378). Both models were compared with the conventional chromatographic techniques. The SVM classification model showed a high sensitivity, specificity, and efficiency (99%). The SVM quantification model determined cocaine content with a root mean squared error of prediction (RMSEP) of 6% calculated over a wide working range from 4 to 99 w%. In conclusion, the developed models resulted in a clear output (cocaine detected or cocaine not detected) and a reliable estimation of the cocaine content in a wide variety of mixtures. The ATR-FTIR technique combined with SVM is a straightforward, user-friendly, and fast approach for routine classification and quantification of cocaine in seized powders. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

  15. Conference proceedings ISES 2014

    DEFF Research Database (Denmark)

    Christensen, Janne Winther; Peerstrup Ahrendt, Line; Malmkvist, Jens

    The 10th Internatinal Equitation Science Conference is held i Denmark from August 6th - 9th 2014. This book of proceedings contaions abstracts of 35 oral and 57 poster presentations within the conference themes Equine Stress, Learning and Training as well as free papers.......The 10th Internatinal Equitation Science Conference is held i Denmark from August 6th - 9th 2014. This book of proceedings contaions abstracts of 35 oral and 57 poster presentations within the conference themes Equine Stress, Learning and Training as well as free papers....

  16. Proceedings of the 8. annual Athabasca oil sands conference : oil sands trade show and conference

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2008-07-01

    This conference featured the latest information on challenges, strategies, technologies, and labour issues facing the heavy oil industry. It was hosted by the world's leading group of experts in the unconventional oil industry and offered prime networking opportunities in an interactive setting for over 500 delegates from around the world. The Athabasca Oil Sands Projects are considered a major source energy supply for North America, which means increased commitments from producing companies to improve environmental impact and enhance the technology used for extraction and refining. Advances in thermal recovery operations, notably steam assisted gravity drainage (SAGD), were highlighted along with new pumping technologies and tailings management issues. The sessions of the conference were entitled: project updates; pumping for the future; and, operational concerns. The conference featured 16 presentations, of which 5 have been catalogued separately for inclusion in this database. tabs., figs.

  17. conference report thai me up, thai me down — the xv ias conference ...

    African Journals Online (AJOL)

    2004-08-01

    Aug 1, 2004 ... hell; it's also fun, vibrant, friendly and safe, with everything from glorious developed-world infrastructure, to a strong sense of culture and vast shopping plazas. .... Kaletra has a resistance barrier that drug developers dream of. Data presented at the Conference showed no resistance to the drug after 5 years ...

  18. Second international conference on isotopes. Conference proceedings

    Energy Technology Data Exchange (ETDEWEB)

    Hardy, C.J. [ed.

    1997-10-01

    The Second International Conference on Isotopes (2ICI) was hosted by the Australian Nuclear Association in Sydney, NSW, Australia. The Theme of the Second Conference: Isotopes for Industry, Health and a Better Environment recognizes that isotopes have been used in these fields successfully for many years and offer prospects for increasing use in the future. The worldwide interest in the use of research reactors and accelerators and in applications of stable and radioactive isotopes, isotopic techniques and radiation in industry, agriculture, medicine, environmental studies and research in general, was considered. Other radiation issues including radiation protection and safety were also addressed. International and national overviews and subject reviews invited from leading experts were included to introduce the program of technical sessions. The invited papers were supported by contributions accepted from participants for oral and poster presentation. A Technical Exhibition was held in association with the Conference. This volume contains the full text or extended abstracts of papers number 61- to number 114

  19. Conference scene: 2nd cancer epigenetics conference.

    Science.gov (United States)

    Smith, Cassandra L

    2013-04-01

    The GTC Cancer Summit: Novel Approaches to Drug Discovery was divided into two parallel tracks: the 2nd Cancer Epigenetics Conference, and the Protein Kinases and Drug Design Conference. The 2nd Cancer Epigenetics Conference focused on exciting changes in drug discovery that include an unprecedented private and public collaboration on drug discovery in epigenetics through the Structural Genomics Consortium (SGC), which has led to several major breakthroughs including: the development of small-molecule inhibitors that interfere with protein interactions, especially bromodomain-containing protein acetylation readers; the indirect but successful targeting of the elusive MYC oncogene; and the identification of epigenetic drugs that are disease-specific. Also reported were the development of clinically useful DNA methylation assays; cell, peptide and protein arrays for testing antibody- and protein-binding specificity; and tools for chromatin capture and DNA modification analysis. Several groups reported on the lack of specificity of some commercial, but unnamed, antibodies used for epigenetic studies.

  20. World Wind

    Data.gov (United States)

    National Aeronautics and Space Administration — World Wind allows any user to zoom from satellite altitude into any place on Earth, leveraging high resolution LandSat imagery and SRTM elevation data to experience...

  1. Defining the Contribution of MC1R Physiological Ligands to ATR Phosphorylation at Ser435, a Predictor of DNA Repair in Melanocytes.

    Science.gov (United States)

    Jarrett, Stuart G; Wolf Horrell, Erin M; Boulanger, Mary C; D'Orazio, John A

    2015-12-01

    The melanocortin 1 receptor (MC1R), a GS-coupled receptor that signals through cAMP and protein kinase A (PKA), regulates pigmentation, adaptive tanning, and melanoma resistance. MC1R-cAMP signaling promotes PKA-mediated phosphorylation of ataxia telangiectasia and rad3-related (ATR) at Ser435 (ATR-pS435), a modification that enhances nucleotide excision repair (NER) by facilitating recruitment of the XPA protein to sites of UV-induced DNA damage. High-throughput methods were developed to quantify ATR-pS435, measure XPA-photodamage interactions, and assess NER function. We report that melanocyte-stimulating hormone (α-MSH) or ACTH induce ATR-pS435, enhance XPA's association with UV-damaged DNA and optimize melanocytic NER. In contrast, MC1R antagonists agouti signaling protein (ASIP) or human β-defensin 3 (HBD3) interfere with ATR-pS435 generation, impair the XPA-DNA interaction, and reduce DNA repair. Although ASIP and HBD3 each blocked α-MSH-mediated induction of the signaling pathway, only ASIP depleted basal ATR-pS435. Our findings confirm that ASIP diminishes agonist-independent MC1R basal signaling whereas HBD3 is a neutral MC1R antagonist that blocks activation by melanocortins. Furthermore, our data suggest that ATR-pS435 may be a useful biomarker for the DNA repair-deficient MC1R phenotype.

  2. Fourth International Conference on Complex Systems

    CERN Document Server

    Minai, Ali A; Unifying Themes in Complex Systems IV

    2008-01-01

    In June of 2002, over 500 professors, students and researchers met in Boston, Massachusetts for the Fourth International Conference on Complex Systems. The attendees represented a remarkably diverse collection of fields: biology, ecology, physics, engineering, computer science, economics, psychology and sociology, The goal of the conference was to encourage cross-fertilization between the many disciplines represented and to deepen understanding of the properties common to all complex systems. This volume contains 43 papers selected from the more than 200 presented at the conference. Topics include: cellular automata, neurology, evolution, computer science, network dynamics, and urban planning. About NECSI: For over 10 years, The New England Complex Systems Institute (NECSI) has been instrumental in the development of complex systems science and its applications. NECSI conducts research, education, knowledge dissemination, and community development around the world for the promotion of the study of complex sys...

  3. Third International Conference on Complex Systems

    CERN Document Server

    Minai, Ali A; Unifying Themes in Complex Systems

    2006-01-01

    In recent years, scientists have applied the principles of complex systems science to increasingly diverse fields. The results have been nothing short of remarkable: their novel approaches have provided answers to long-standing questions in biology, ecology, physics, engineering, computer science, economics, psychology and sociology. The Third International Conference on Complex Systems attracted over 400 researchers from around the world. The conference aimed to encourage cross-fertilization between the many disciplines represented and to deepen our understanding of the properties common to all complex systems. This volume contains over 35 papers selected from those presented at the conference on topics including: self-organization in biology, ecological systems, language, economic modeling, ecological systems, artificial life, robotics, and complexity and art. ALI MINAI is an Affiliate of the New England Complex Systems Institute and an Associate Professor in the Department of Electrical and Computer Engine...

  4. Third International Conference on Complex Systems

    CERN Document Server

    Minai, Ali A; Unifying Themes in Complex Systems

    2006-01-01

    In recent years, scientists have applied the principles of complex systems science to increasingly diverse fields. The results have been nothing short of remarkable: their novel approaches have provided answers to long-standing questions in biology, ecology, physics, engineering, computer science, economics, psychology and sociology. The Third International Conference on Complex Systems attracted over 400 researchers from around the world. The conference aimed to encourage cross-fertilization between the many disciplines represented and to deepen our understanding of the properties common to all complex systems. This volume contains selected transcripts from presentations given at the conference. Speakers include: Chris Adami, Kenneth Arrow, Michel Baranger, Dan Braha, Timothy Buchman, Michael Caramanis, Kathleen Carley, Greg Chaitin, David Clark, Jack Cohen, Jim Collins, George Cowan, Clay Easterly, Steven Eppinger, Irving Epstein, Dan Frey, Ary Goldberger, Helen Harte, Leroy Hood, Don Ingber, Atlee Jackson,...

  5. Radiation`96. Conference handbook

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-12-31

    The conference program includes eight invited lectures which cover a range of contemporary topics in radiation science and technology. In addition, thirty-two oral papers were presented, along with forty-five posters. The conference handbook contains one-page precis or extended abstracts of all presentations, and is a substantial compendium of current radiation research in Australia.

  6. The Vision Conference

    DEFF Research Database (Denmark)

    Vidal, Rene Victor Valqui

    2002-01-01

    The concept of the design, planning and mangement of a creative conference is presented. A case study illustrates the theoretical concepts.......The concept of the design, planning and mangement of a creative conference is presented. A case study illustrates the theoretical concepts....

  7. Vehicular Networking Conference (VNC)

    NARCIS (Netherlands)

    Altintas, O.; Chen, W.; Heijenk, Geert; Dressler, F.; Ekici, E.; Kargl, Frank; Shigeno, H.; Dietzel, Stefan

    2011-01-01

    On behalf of the Organizing Committee, we would like to welcome you to the third edition of the IEEE Vehicular Networking Conference (IEEE VNC 2011) in Amsterdam, the Netherlands. IEEE VNC is a unique conference sponsored by both the IEEE Communications Society and the IEEE Intelligent

  8. Energy world governance. Review of the conference which was held at IFRI, 26 March 2009, with Tatsuo Masuda, Andre Mernier et Richard H. Jones; La gouvernance mondiale de l'Energie - Resume de la conference qui a eu lieu a l'Ifri le 26 Mar 2009 autour de Tatsuo Masuda, Andre Mernier et Richard H. Jones

    Energy Technology Data Exchange (ETDEWEB)

    Schulke, Ch.

    2009-07-01

    The conference was related with some of the major questions concerning global energy governance today, the role of the different international organizations dealing with energy, the rules of the game between market and state players, the efforts to deal with climate change, and the integration of emerging countries in global energy governance, the roles of the different international organizations dealing with energy (will we see further fragmentation or more cooperation between them?). Tatsuo Masuda in his contribution discussed global energy governance from an oil perspective. Andre Mernier noted the particular nature of the Energy Charter, which, as it is founded upon an international treaty, is unlike other organizations in being legally binding. The legal basis of the organization means that agreements are especially powerful. Then Richard H. Jones underlined that last summer's volatility in oil markets, the ensuing financial and economic crisis, the major disruption in gas supplies to European markets this winter and the upcoming climate change negotiations have led to increasing calls for a stronger global dialogue on energy issues. This dialogue should deal with prices and investment, energy security and climate change

  9. ICCK Conference Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Green, William H. [MIT

    2013-05-28

    The 7th International Conference on Chemical Kinetics (ICCK) was held July 10-14, 2011, at Massachusetts Institute of Technology (MIT), in Cambridge, MA, hosted by Prof. William H. Green of MIT's Chemical Engineering department. This cross-disciplinary meeting highlighted the importance of fundamental understanding of elementary reactions to the full range of chemical investigations. The specific conference focus was on elementary-step kinetics in both the gas phase and in condensed phase. The meeting provided a unique opportunity to discuss how the same reactive species and reaction motifs manifest under very different reaction conditions (e.g. atmospheric, aqueous, combustion, plasma, in nonaqueous solvents, on surfaces.). The conference featured special sessions on new/improved experimental techniques, improved models and data analysis for interpreting complicated kinetics, computational kinetics (especially rate estimates for large kinetic models), and a panel discussion on how the community should document/archive kinetic data. In the past, this conference had been limited to homogeneous gas-phase and liquid-phase systems. This conference included studies of heterogeneous kinetics which provide rate constants for, or insight into, elementary reaction steps. This Grant from DOE BES covered about half of the subsidies we provided to students and postdocs who attended the conference, by charging them reduced-rate registration fees. The complete list of subsidies provided are listed in Table 1 below. This DOE funding was essential to making the conference affordable to graduate students, and indeed the attendance at this conference was higher than at previous conferences in this series. Donations made by companies provided additional subsidies, leveraging the DOE funding. The conference was very effective in educating graduate students and important in fostering scientific interactions, particularly between scientists studying gas phase and liquid phase

  10. 3rd Cryocooler Conference

    CERN Document Server

    Louie, Berverly; McCarthy, Sandy

    1985-01-01

    Cryocoolers 3 documents the output of the Third Cryocooler Conference, held at the National Bureau of Standards, Boulder, Colorado, on September 17-18, 1984. About 140 people from 10 countries attended the conference representing industry, government, and academia. A total of 26 papers were presented orally at the conference and all appear in written form in the proceedings. The focus of this conference was on small cryocoolers in the temperature range of 4 - 80 K. Mechanical and nonmechanical types are discussed in the various papers. Applications of these small cryocoolers include the cooling of infrared detectors, cryopumps, small superconducting devices and magnets, and electronic devices. The conference proceedings reproduced here was published by the National Bureau of Standards in Boulder, Colorado as NBS Special Publication #698.

  11. Differential Processing of Low and High LET Radiation Induced DNA Damage: Investigation of Switch from ATM to ATR Signaling

    Science.gov (United States)

    Saha, Janapriya; Wang, Minli; Hada, Megumi; Cucinotta, Francis A.

    2011-01-01

    The members of the phosphatidylinositol kinase-like kinase family of proteins namely ataxia-telangiectasia mutated (ATM) and ATM- and Rad3-related (ATR) are directly responsible for the maintenance of genomic integrity by mounting DDR through signaling and facilitating the recruitment of repair factors at the sites of DNA damage along with coordinating the deployment of cell cycle checkpoints to permit repair by phosphorylating Checkpoint kinase Chk1, Chk2 and p53. High LET radiation from GCR (Galactic Cosmic Rays) consisting mainly of protons and high energy and charged (HZE) particles from SPE (Solar Particle Event) pose a major health risk for astronauts on their space flight missions. The determination of these risks and the design of potential safeguards require sound knowledge of the biological consequences of lesion induction and the capability of the cells to counter them. We here strive to determine the coordination of ATM and ATR kinases at the break sites directly affecting checkpoint signaling and DNA repair and whether differential processing of breaks induced by low and high LET radiation leads to possible augmentation of swap of these damage sensors at the sites of DNA damage. Exposure of cells to IR triggers rapid autophosphorylation of serine-1981 that causes dimer dissociation and initiates monomer formation of ATM. ATM kinase activity depends on the disruption of the dimer, which allows access and phosphorylation of downstream ATM substrates like Chk2. Evidence suggests that ATM is activated by the alterations in higher-order chromatin structure although direct binding of ATM to DSB ends may be a crucial step in its activation. On the other hand, in case of ATR, RPA (replication protein A)-coated ssDNA (single-stranded DNA) generated as a result of stalled DNA replication or during processing of chromosomal lesions is crucial for the localization of ATR to sites of DNA damage in association with ATR-interacting protein (ATRIP). Although the

  12. The Proceedings of the Panel “Effects of Air Pollution on Human Health, Air Pollution Problem in the World, Turkey and Our Region” (The Conference Hall of Dicle University, Diyarbakır 24.12.2004

    Directory of Open Access Journals (Sweden)

    Hasan Bayram

    2006-01-01

    Full Text Available Air pollution still exceeds safe limits worldwide, particularly in big metropolitans, despite regular monitoring facilities and measures taken. It is usually originated from industrial activities, fossil fuel use in domestic settings and vehicle exhaust emission. Although there is a decrease in air pollution in big cities of Turkey due to use of natural gas, it is still a serious health concern. In Diyarbakır, because of a rapid increase in its population recently, wrong urbanisation and a relative increase in industrialisation, air pollution leads to dangerous levels, particularly in the winter. Epidemiological studies from all over the world, and Turkey have reported a close relation between air pollution and respiratory morbidity and mortality. Studies investigating the mechanisms underlying respiratory effects of air pollution demonstrated that pollutants lead to increased respiratory symptoms, decreased respiratory function and induce inflammatory changes in airways. In vitro studies have shown that air pollutants exert their effects by causing cellular injury directly, and by activating intracellular oxidative pathways indirectly. The attempts to reduce air pollution levels have been implemented in Turkey and worldwide. In order to solve the problem in Diyarbakır, several measures such as prevention the use of out standardized fuel, use of reliable burning techniques, and a close car emission monitoring system need to be implemented.

  13. Second international conference on isotopes. Conference proceedings

    Energy Technology Data Exchange (ETDEWEB)

    Hardy, C.J. [ed.

    1997-10-01

    The Second International Conference on Isotopes (2ICI) was hosted by the Australian Nuclear Association in Sydney, NSW, Australia. The Theme of the Second Conference: Isotopes for Industry, Health and a Better Environment recognizes that isotopes have been used in these fields successfully for many years and offer prospects for increasing use in the future. The worldwide interest in the use of research reactors and accelerators and in applications of stable and radioactive isotopes, isotopic techniques and radiation in industry, agriculture, medicine, environmental studies and research in general, was considered. Other radiation issues including radiation protection and safety were also addressed. International and national overviews and subject reviews invited from leading experts were included to introduce the program of technical sessions. The invited papers were supported by contributions accepted from participants for oral and poster presentation. A Technical Exhibition was held in association with the Conference. This volume contains the foreword, technical program, the author index and of the papers (1-60) presented at the conference.

  14. To conference or not to conference

    African Journals Online (AJOL)

    Society for the Study of Hypertension in Pregnancy (ISSHP), the International Urogynaecology ... subject, of treatments or techniques they would never use, and why, or of treatments, interventions or tests which they ... colleagues recounted advice given over conference coffee – the one of obligatory consent for laparoscopy ...

  15. Common aspirations of world women.

    Science.gov (United States)

    Huang, B

    1996-02-01

    The comments of the Director of Foreign Affairs for the China State Family Planning Commission reflect satisfaction with the achievements at the Fourth World Conference on Women held in Beijing. It is posited that the historic documents from the conference reflect the common aspirations of all women in the world for equality, development, and peace. The conference's focus on social development for women has been translated in China into a "vigorous" IEC campaign. China is developing integrated approaches to family planning in rural areas. The approach aims to help rural women to become economically independent before achieving equality within the family and society. A National Conference on Integrated Programs was held in Sichuan province. Examples of integrated programs in Sichuan, Jilin, and Jiangsu were described for conference participants. The example is given of how poor rural women in Deyang Prefecture, Sichuan province, have received credit for income generation and access to skill development and literacy classes. Continuous economic and social development are important for achieving "poverty eradication and the liberation of women." Sustainable development involves use of resources, environmental protection, the reasonable change in consumption patterns, and transitional changes in modes of production. The concept of reproductive health means Chinese family planning workers must meet higher standards. Future plans include intensifying the IEC program in meeting the comprehensive biological, psychological, and social reproductive health needs of women. Respect must be given to the fertility intentions and reproductive rights of wives and husbands. "In China, voluntary choice of childbearing should be guided by the fertility policy formulated by the government." Training of family planning workers should be intensified to include training in public health, reproductive theory, contraception, and the techniques of interpersonal communication. Some provinces

  16. China's Soft Diplomacy in an Emerging Multi-polar World

    DEFF Research Database (Denmark)

    Schmidt, Johannes Dragsbæk

    Keynote presentation for the conference"The Growing Prominence of China on the World Stage: Exploring the Political, Economic, and Cultural Relations of China and Global Stakeholders" International Conference, Berlin, September 15th - 18th, 2011 - Held Parallel to the "Berlin - Asia Pacific Weeks...

  17. In-Situ ATR-FTIR and Surface Complexation Modeling Study of the Adsorption of Dimethylarsenic Acid and p-Arsanilic Acid on Iron Oxides

    Science.gov (United States)

    Goldberg, S. R.; Al-Abadleh, H.; Mitchell, W.

    2010-12-01

    Arsenic is an element that exists naturally in many rocks and minerals around the world, accumulates in petroleum, shale, and coal deposits as a result of biogeochemical processes, and is found in fly ash from fuel combustion. Arsenic compounds in their organic and inorganic forms pose both health and environmental risks. The environmental fate of arsenic compounds is controlled to a large extent by their surface interactions with inorganic and organic surfaces. We report results from applying the triple layer surface complexation model to adsorption isotherm and pH-envelope experimental data of dimethylarsenic acid, DMA, and p-arsanilic acid, p-AsA on the iron oxides, hematite and goethite. Ligand exchange reactions were based on the interpretation of ATR-FTIR spectra of DMA and p-AsA surface complexes. Surface coverage of the organoarsenicals was quantified in-situ from the spectral component at 840 cm-1. The best model fit to the DMA adsorption data was obtained using an outer-sphere complex, whereas for p-AsA, best model fit was obtained using two monodentate inner-sphere surface complexes. The significance of the results is discussed in relation to improving modeling tools used by environmental regulators. Accurate predictive modeling tools are needed for effective design of arsenic removal technologies using iron oxide minerals.

  18. In situ ATR-FTIR and surface complexation modeling studies on the adsorption of dimethylarsinic acid and p-arsanilic acid on iron-(oxyhydr)oxides.

    Science.gov (United States)

    Mitchell, William; Goldberg, Sabine; Al-Abadleh, Hind A

    2011-06-15

    Arsenic is an element that exists naturally in many rocks and minerals around the world. It also accumulates in petroleum, shale, oil sands, and coal deposits as a result of biogeochemical processes, and it has been found in fly ash from the combustion of solid biofuels. Arsenic compounds in their organic and inorganic forms pose both a health and an environmental risk, and continue to be a challenge to the energy industry. The environmental fate and removal technologies of arsenic compounds are controlled to a large extent by their surface interactions with inorganic and organic adsorbents. We report thermodynamic binding constants, K(binding), from applying the triple-layer surface complexation model to adsorption isotherm and pH envelope data for dimethylarsinic acid (DMA) and p-arsanilic acid (p-AsA) on hematite and goethite. Ligand exchange reactions were constructed based on the interpretation of ATR-FTIR spectra of DMA and p-AsA surface complexes. Surface coverage of adsorbates was quantified in situ from the spectral component at 840 cm(-1). The best fit to the DMA adsorption data was obtained using outer-sphere complex formation, whereas for p-AsA, the best fit was obtained using two monodentate inner-sphere surface complexes. The significance of the results is discussed in relation to improving modeling tools used by environmental regulators and the energy sector for optimum control of arsenic content in fuels. Copyright © 2011 Elsevier Inc. All rights reserved.

  19. Variability and robustness of scatterers in HRR/ISAR ground target data and its influence on the ATR performance

    Science.gov (United States)

    Schumacher, R.; Schimpf, H.; Schiller, J.

    2011-06-01

    The most challenging problem of Automatic Target Recognition (ATR) is the extraction of robust and independent target features which describe the target unambiguously. These features have to be robust and invariant in different senses: in time, between aspect views (azimuth and elevation angle), between target motion (translation and rotation) and between different target variants. Especially for ground moving targets in military applications an irregular target motion is typical, so that a strong variation of the backscattered radar signal with azimuth and elevation angle makes the extraction of stable and robust features most difficult. For ATR based on High Range Resolution (HRR) profiles and / or Inverse Synthetic Aperture Radar (ISAR) images it is crucial that the reference dataset consists of stable and robust features, which, among others, will depend on the target aspect and depression angle amongst others. Here it is important to find an adequate data grid for an efficient data coverage in the reference dataset for ATR. In this paper the variability of the backscattered radar signals of target scattering centers is analyzed for different HRR profiles and ISAR images from measured turntable datasets of ground targets under controlled conditions. Especially the dependency of the features on the elevation angle is analyzed regarding to the ATR of large strip SAR data with a large range of depression angles by using available (I)SAR datasets as reference. In this work the robustness of these scattering centers is analyzed by extracting their amplitude, phase and position. Therefore turntable measurements under controlled conditions were performed targeting an artificial military reference object called STANDCAM. Measures referring to variability, similarity, robustness and separability regarding the scattering centers are defined. The dependency of the scattering behaviour with respect to azimuth and elevation variations is analyzed. Additionally generic types

  20. World Bioenergy 2012. Proceedings

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2012-11-01

    The conference of 2012 had contributions on the following themes: A: World Pellets 2012, B: Market outlook, C: Energy systems, D: Transportation, E: World biorefinery 2012, F: Sustainable bioenergy day. 52 contributions in A - D. A: World Pellets 2012 is an integrated part of World Bioenergy 2012. A three day 'conference in the conference' covering all aspects of pellets: raw material potentials, innovative pellets production systems, torrefaction, new combustion technologies, trade and market development, health and safety aspects, etc. B) Market outlook: Policy and targets for renewable energy to find an alternative to fossil energy are being put in place, increasing the demand for sustainable modern bioenergy. Global trade and improved logistics open up to the markets. To facilitate international trade in bioenergy commodities, new trading places and indexes are needed, as well as generally accepted standards. Supply and demand must meet to guarantee stable prices. In this session you learn all about current market development, including drivers like incentives and policies. C) Energy Systems: Modern bioenergy is a young industry. Therefore, technical development is rapid, with many new innovations. This session focuses on technical development in the whole bioenergy chain, from harvesting of forest residues to combustion technologies and co-firing. Optimal use of biomass through district heating or cooling - small scale and large scale - and CHP technology for electricity production. D) Transportation: Sustainable transports are one of the key challenges of tomorrow. Can we transport biomass as well as other products sustainably and at what costs? Which are the future fuels for transports and when will biofuels be viewed as profitable? Biofuels for transport are under rapid development with new methods, producers and feedstock entering the markets. The future biofuels will be produced in biorefineries, to increase profitability and optimize feed

  1. Chronicle: Individual, Nation And Society In Postmodern World

    National Research Council Canada - National Science Library

    Edvardas Rimkus

    2013-01-01

    .... Participants of the conference gathered to exchange their thoughts on these topics: human identity, individual and nation, individual and society, influence of media to culture, condition of democracy and culture in the global world...

  2. Student Support for EIPBN 2012 Conference

    Energy Technology Data Exchange (ETDEWEB)

    Farrow, Reginald C

    2013-01-29

    The 56th International Conference on Electron, Ion and Photon Beam Technology and Nanofabrication (EIPBN), 2012, was held at the Hilton Waikoloa Resort in Waikoloa, Hawaii, May 29 - June 2, 2012. The EIPBN Conference is recognized as the foremost international meeting dedicated to lithographic science and technology and its application to micro and nanofabrication techniques. The conference brought together 483 engineers and scientists from industries and universities from all over the world to discuss recent progress and future trends. Among the emerging technologies that are within the scope of EIPBN is Nanofabrication for Energy Sources along with nanofabrication for the realization of low power integrated circuits. Every year, EIPBN provides financial support for students to attend the conference. The students gave oral and poster presentations of their research and many published peer reviewed articles in a special conference issue of the Journal of Vacuum Science and Technology B. The Department of Energy Office of Basic Energy Sciences partially supported 41 students from US universities with a $5,000.

  3. Worlds Smaller than Saturn

    Science.gov (United States)

    2001-03-01

    Computerized animations show the following: (1) an artist's conception of a Saturn-like extrasolar planet; (2) star and planet motion; and (3) young stellar disk and planet formation. Footage shows the outside of the Mauna Kea Observatories in Hawaii and Geoff Marcy and Paul Butler inside while they are processing information. Then a press conference,'Worlds Smaller than Saturn', is seen. Anne Kinney, Origins Science Director, NASA Headquarters, introduces Geoff Marcy, Paul Butler, Alan Boss, and Heidi Hammel. They discuss the discovery of the two new Saturn-sized extrasolar planets that are orbiting the stars HD46375 and 79 Seti, giving details on the search technique and size distribution. They then answer questions from the press.

  4. Status Report on the Fabrication of Fuel Cladding Chemical Interaction Test Articles for ATR Irradiations

    Energy Technology Data Exchange (ETDEWEB)

    Field, Kevin G. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Howard, Richard H. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2015-09-28

    FeCrAl alloys are a promising new class of alloys for light water reactor (LWR) applications due to their superior oxidation and corrosion resistance in high temperature environments. The current R&D efforts have focused on the alloy composition and processing routes to generate nuclear grade FeCrAl alloys with optimized properties for enhanced accident tolerance while maintaining properties needed for normal operation conditions. Therefore, the composition and processing routes must be optimized to maintain the high temperature steam oxidation (typically achieved by increasing the Cr and Al content) while still exhibiting properties conducive to normal operation in a LWR (such as radiation tolerance where reducing Cr content is favorable). Within this balancing act is the addition of understanding the influence on composition and processing routes on the FeCrAl alloys for fuel-cladding chemical interactions (FCCI). Currently, limited knowledge exists on FCCI for the FeCrAl-UO2 clad-fuel system. To overcome the knowledge gaps on the FCCI for the FeCrAl-UO2 clad-fuel system a series of fueled irradiation tests have been developed for irradiation in the Advanced Test Reactor (ATR) housed at the Idaho National Laboratory (INL). The first series of tests has already been reported. These tests used miniaturized 17x17 PWR fuel geometry rodlets of second-generation FeCrAl alloys fueled with industrial Westinghouse UO2 fuel. These rodlets were encapsulated within a stainless steel housing.To provide high fidelity experiments and more robust testing, a new series of rodlets have been developed deemed the Accident Tolerant Fuel Experiment #1 Oak Ridge National Laboratory FCCI test (ATF-1 ORNL FCCI). The main driving factor, which is discussed in detail, was to provide a radiation environment where prototypical fuel-clad interface temperatures are met while still maintaining constant contact between industrial fuel and the candidate cladding alloys

  5. A Thematic Approach to Pamfil Seicaru's Conferences

    Directory of Open Access Journals (Sweden)

    Fănel Teodoraşcu

    2014-12-01

    Full Text Available There are many voices which claim that Pamfil Șeicaru did not benefit from the interwar public's appreciation. He was perceived as a human being eager to get rich using any kind of means. But Pamfil Șeicaru can be considered a star of the press of the period between the two world wars. His prestige is also proven by the numerous conferences which he held in the most important Romanian cities during the interwar period.

  6. CLIMA 2016 - proceedings of the 12th REHVA World Congress

    DEFF Research Database (Denmark)

    CLIMA 2016, 12th REHVA World Congress 2016 in Aalborg north of Denmark. Full reviewed papers presented at CLIMA 2016 is published in the conference proceedings. This volume contains the sessions number 1 + 2 + 3 from track "Building Retrofit".......CLIMA 2016, 12th REHVA World Congress 2016 in Aalborg north of Denmark. Full reviewed papers presented at CLIMA 2016 is published in the conference proceedings. This volume contains the sessions number 1 + 2 + 3 from track "Building Retrofit"....

  7. CLIMA 2016 - proceedings of the 12th REHVA World Congress

    DEFF Research Database (Denmark)

    CLIMA 2016, 12th REHVA World Congress 2016 in Aalborg north of Denmark. Full reviewed papers presented at CLIMA 2016 is published in the conference proceedings. This volume contains the sessions number 34 + 35 +36 from track "Commissioning, Control & Energy Mangement".......CLIMA 2016, 12th REHVA World Congress 2016 in Aalborg north of Denmark. Full reviewed papers presented at CLIMA 2016 is published in the conference proceedings. This volume contains the sessions number 34 + 35 +36 from track "Commissioning, Control & Energy Mangement"....

  8. CLIMA 2016 - proceedings of the 12th REHVA World Congress

    DEFF Research Database (Denmark)

    CLIMA 2016, 12th REHVA World Congress 2016 in Aalborg north of Denmark. Full reviewed papers presented at CLIMA 2016 is published in the conference proceedings. This volume contains the sessions number 4 + 5 + 6 + 7 from track "Building Technologies".......CLIMA 2016, 12th REHVA World Congress 2016 in Aalborg north of Denmark. Full reviewed papers presented at CLIMA 2016 is published in the conference proceedings. This volume contains the sessions number 4 + 5 + 6 + 7 from track "Building Technologies"....

  9. CLIMA 2016 - proceedings of the 12th REHVA World Congress

    DEFF Research Database (Denmark)

    CLIMA 2016, 12th REHVA World Congress 2016 in Aalborg north of Denmark. Full reviewed papers presented at CLIMA 2016 is published in the conference proceedings. This volume contains the sessions number 14 + 15 + 16 from track "Energy Flexibility & Storage".......CLIMA 2016, 12th REHVA World Congress 2016 in Aalborg north of Denmark. Full reviewed papers presented at CLIMA 2016 is published in the conference proceedings. This volume contains the sessions number 14 + 15 + 16 from track "Energy Flexibility & Storage"....

  10. CLIMA 2016 - proceedings of the 12th REHVA World Congress

    DEFF Research Database (Denmark)

    CLIMA 2016, 12th REHVA World Congress 2016 in Aalborg north of Denmark. Full reviewed papers presented at CLIMA 2016 is published in the conference proceedings. This volume contains the sessions number 31 + 32 + 33 from track "Building Performance".......CLIMA 2016, 12th REHVA World Congress 2016 in Aalborg north of Denmark. Full reviewed papers presented at CLIMA 2016 is published in the conference proceedings. This volume contains the sessions number 31 + 32 + 33 from track "Building Performance"....

  11. Beijing: a conference of commitments?

    Science.gov (United States)

    Davis, S

    1996-05-01

    The author of this article holds the view that the Declaration and Platform for Action at the UN Fourth World Conference on Women held in Beijing in 1995 was the product of the most highly participatory process ever organized under the auspices of the UN. The Declaration and Platform expressed the strongest views on gender equality, empowerment, and justice that governments have ever endorsed. These documents were the consolidation of gains made by women in previous UN conferences. The 135-page Platform can be used at all levels of decision making. Governments and international can be held accountable for its provisions. The Platform exposes the problems violence and exploitation against women and girls as well as the revelation that environmental destruction is due to an unsustainable pattern of consumption and production, particularly in developed countries. Conference participants included about 3000 nongovernmental groups (NGOs). The Women's Linkage Caucus and WEDO served to facilitate the advocacy process by providing briefings on text still under negotiation and providing on-line recommendations from the 1995 and 1994 Commission on the Status of Women preparatory committee meetings. A scoreboard that tracked government's commitment at the 1995 preparatory committee meetings was reinstated in Beijing. The information was conveyed on the Internet. The European Union is credited with diluting the language about government commitment to the Platform. Governments are still given responsibility for implementation, and the need for political will is stressed (paragraph 293). Paragraph 297 indicates the process for implementation of the Platform and coordination with NGOs. Although the Platform recognizes the importance of women's groups and other NGOs, the responsibility for implementation is still given to governments.

  12. Turkish ELT Professionals' Conference Attendance Motives: Why Do They Attend and What Do They Take Back Home?

    Science.gov (United States)

    Büyükyavuz, Oya

    2016-01-01

    Around the world many professionals attend conferences. The professionals working in the field of English language teaching (ELT) are not exceptions. Along with two major international conferences organized for ELT professionals, TESOL and IATEFL, there are a great number of other conferences organized by affiliated professional associations in…

  13. ATR-FTIR Spectroscopy on intact dried leaves of sage (Salvia officinalis L. – chemotaxonomic discrimination and essential oil composition

    Directory of Open Access Journals (Sweden)

    Gudi, Gennadi

    2016-07-01

    Full Text Available Sage (Salvia officinalis L. is cultivated worldwide for its aromatic leaves which are used as herbal spice and for phytopharmaceutical applications. Fast analytical strategies for essential oil analysis, performed directly on plant material would reduce the delay between sampling and analytical results. This would enhance product quality by improving technical control of cultivation. The attenuated total reflectance Fourier transform infrared (ATR-FTIR spectroscopy method described here provides a reliable calibration model for quantification of essential oil components (EOC and its main constituents (e.g. -thujone and -thujone directly on dried, intact leaves of sage. Except for drying no further sample preparation is required for ATR-FTIR and the measurement time of less than 5 min per sample contrasts with the most common alternative of hydro-distillation followed by GC analysis which can take several hours per sample.

  14. Thermal behaviors of stainless steel tube based GeO2 ATR hollow fibers for transmitting CO2 laser radiations

    Science.gov (United States)

    Wang, Xu; Wang, Lin; Fu, Xiaohong; Jing, Chengbin; Yue, Fangyu; Yang, Pingxiong; Chu, Junhao

    2017-10-01

    The stainless steel (SUS) capillary tube attenuated total reflective (ATR) GeO2 hollow waveguide has advantages of low fabrication cost, strong mechanic strength and low transmission loss. It can find laser power delivery applications such as laser surgery, and material processing. However, the temperature rise of the operating waveguide may affect the laser delivery stability and the laser surgery safety. The thermal behaviors of the SUS ATR hollow fiber transmitting CO2 laser were investigated theoretically and experimentally in this work. Both theoretic simulations and experimental results disclose the periodic oscillatory behavior of the fiber temperature. The influence of input laser power on fiber temperature has been quantitatively discussed. A maximum input laser power of 23 W is predicted for laser surgery in which case the fiber temperature had better be lower than 47 °C to avoid tissue scalds. An input laser power smaller than 137 W is suggested preventing the fiber from being overheated (150 °C).

  15. FOREWORD: HELAS II International Conference

    Science.gov (United States)

    Gizon, Laurent; Roth, Markus

    2008-07-01

    Volume 118 (2008) of Journal of Physics: Conference Series provides a written record of the talks and posters presented at the HELAS II International Conference `Helioseismology, Asteroseismology and MHD Connections'. The conference was held during the week 20-24 August 2007 in Göttingen, Germany, jointly hosted by the Max Planck Institute for Solar System Research and the Faculty of Physics of the University of Göttingen. A total of 140 scientists from all over the world attended. The Scientific Organizing Committee consisted of Conny Aerts, Annie Baglin, Jørgen Christensen-Dalsgaard, Thierry Corbard, Jadwiga Daszyńska-Daszkiewicz, Stefan Dreizler, Yvonne Elsworth, Laurent Gizon (Chairman), Wolfgang Glatzel, Frank Hill, Donald Kurtz, Oskar von der Lühe, Maria Pia Di Mauro, Mário Monteiro, Pere Pallé, Markus Roth, Philip Scherrer, Manfred Schüssler, and Michael Thompson. HELAS stands for the European Helio- and Asteroseismology Network, a Coordination Action supported by the sixth Framework Programme of the European Union. It aims to bring together researchers in the fields of solar and stellar oscillations. This volume consists of 91 articles organized into sections that reflect the scientific programme of the conference: 012001-07 Wave diagnostics in physics, geophysics and astrophysics 012008-09 Perspectives on helio- and asteroseismology 012010-17 Asteroseismology: Observations 012018-25 Asteroseismology: Theory 012026-32 Global helioseismology and solar models 012033-38 Local helioseismology and magnetic activity 012039-44 Future observational projects in helio- and asteroseismology 012045-91 Poster papers. The overwhelming majority of papers discuss the seismology of the Sun and stars. Papers in the first section provide a broader perspective on wave phenomena and techniques for probing other physical systems, from living beings to the universe as a whole. We were extremely fortunate to have particularly distinguished experts to cover these topics

  16. The Eighth Central European Conference ?Chemistry towards Biology?: Snapshot?

    OpenAIRE

    Perczel, Andr?s; Atanasov, Atanas G.; Sklen??, Vladim?r; Nov??ek, Ji??; Papou?kov?, Veronika; Kade??vek, Pavel; ??dek, Luk??; Koz?owski, Henryk; Wat?y, Joanna; Hecel, Aleksandra; Ko?kowska, Paulina; Ko?a, Jaroslav; Svobodov?-Va?ekov?, Radka; Pravda, Luk??; Sehnal, David

    2016-01-01

    The Eighth Central European Conference “Chemistry towards Biology” was held in Brno, Czech Republic, on August 28–September 1, 2016 to bring together experts in biology, chemistry and design of bioactive compounds; promote the exchange of scientific results, methods and ideas; and encourage cooperation between researchers from all over the world. The topics of the conference covered “Chemistry towards Biology”, meaning that the event welcomed chemists working on biology-related problems, biol...

  17. IEEE Nuclear Science Symposium and Medical Imaging Conference

    CERN Document Server

    2016-01-01

    The NSS/MIC is a well-established meeting that has continuously provided an exceptional venue to showcase outstanding developments and contributions across the nuclear and medical instrumentation fields. This conference brings together engineers and scientists from around the world to share their knowledge and to gain insight and inspiration from others. The conference will include a distinguished series of short courses, relevant refresher courses, and workshops that will address areas of particular interest.

  18. Spinning worlds

    NARCIS (Netherlands)

    Schwarz, H.

    2017-01-01

    The thesis "Spinning Worlds" is about the characterisation of two types of gas-giant exoplanets: Hot Jupiters, with orbital periods of fewer than five days, and young, wide-orbit gas giants, with orbital periods as long as thousands of years. The thesis is based on near-infrared observations of 1

  19. AGR-2 Final Data Qualification Report for U.S. Capsules - ATR Cycles 147A Through 154B

    Energy Technology Data Exchange (ETDEWEB)

    Pham, Binh T. [Idaho National Lab. (INL), Idaho Falls, ID (United States). Very High-Temperature Reactor Technology Development Office; Einerson, Jeffrey J. [Idaho National Lab. (INL), Idaho Falls, ID (United States). Very High-Temperature Reactor Technology Development Office

    2014-07-01

    This report provides the data qualification status of AGR-2 fuel irradiation experimental data in four U.S. capsules from all 15 Advanced Test Reactor (ATR) Cycles 147A, 148A, 148B, 149A, 149B, 150A, 150B, 151A, 151B, 152A, 152B, 153A, 153B, 154A, and 154B, as recorded in the Nuclear Data Management and Analysis System (NDMAS). Thus, this report covers data qualification status for the entire AGR-2 irradiation and will replace four previously issued AGR-2 data qualification reports (e.g., INL/EXT-11-22798, INL/EXT-12-26184, INL/EXT-13-29701, and INL/EXT-13-30750). During AGR-2 irradiation, two cycles, 152A and 153A, occurred when the ATR core was briefly at low power, so AGR-2 irradiation data are not used for physics and thermal calculations. Also, two cycles, 150A and 153B, are Power Axial Locator Mechanism (PALM) cycles when the ATR power is higher than during normal cycles. During the first PALM cycle, 150A, the experiment was temporarily moved from the B-12 location to the ATR water canal and during the second PALM cycle, 153B, the experiment was temporarily moved from the B-12 location to the I-24 location to avoid being overheated. During the “Outage” cycle, 153A, seven flow meters were installed downstream from seven Fission Product Monitoring System (FPMS) monitors to measure flows from the monitors and these data are included in the NDMAS database.

  20. Raman and IR-ATR spectroscopy studies of heteroepitaxial structures with a GaN:C top layer

    Science.gov (United States)

    Cerqueira, M. F.; Vieira, L. G.; Alves, A.; Correia, R.; Huber, M.; Andreev, A.; Bonanni, A.; Vasilevskiy, M. I.

    2017-09-01

    This work, motivated by the technologically important task of determination of carbon dopant location in the GaN crystal lattice, employed Raman spectroscopy, with both resonant and non-resonant excitation, and infrared (IR) spectroscopy, in the attenuated total reflection (ATR) configuration, to study lattice vibration modes in a set of carbon-doped GaN (GaN:C) epilayers grown by metalorganic vapour phase epitaxy. We analyse Raman and IR-ATR spectra from the point of view of possible effects of the carbon doping, namely: (i) local vibration mode of C atoms in the nitrogen sublattice (whose frequency we theoretically estimate as 768 cm-1 using an isotope defect model), and (ii) shift in the positions of longitudinal modes owing to the phonon-plasmon coupling. We find only indirect hints of the doping effect on the resonant Raman spectra. However, we show theoretically and confirm experimentally that the IR-ATR spectroscopy can be a much more sensitive tool for this purpose, at least for the considered structures. A weak perturbation of the dielectric function of GaN:C, caused by the substitutional carbon impurity, is shown to produce a measurable dip in the ATR reflectivity spectra at  ≈770 cm-1 for both p- and s-polarizations. Moreover, it influences a specific (guided-wave type) mode observed at  ≈737 cm-1, originating from the GaN layer, which appears in the narrow frequency window where the real parts of the two components of the dielectric tensor of the hexagonal crystal have opposite signs. This interpretation is supported by our modelling of the whole multilayer structure, using a transfer matrix formalism.

  1. Conference on Large Scale Optimization

    CERN Document Server

    Hearn, D; Pardalos, P

    1994-01-01

    On February 15-17, 1993, a conference on Large Scale Optimization, hosted by the Center for Applied Optimization, was held at the University of Florida. The con­ ference was supported by the National Science Foundation, the U. S. Army Research Office, and the University of Florida, with endorsements from SIAM, MPS, ORSA and IMACS. Forty one invited speakers presented papers on mathematical program­ ming and optimal control topics with an emphasis on algorithm development, real world applications and numerical results. Participants from Canada, Japan, Sweden, The Netherlands, Germany, Belgium, Greece, and Denmark gave the meeting an important international component. At­ tendees also included representatives from IBM, American Airlines, US Air, United Parcel Serice, AT & T Bell Labs, Thinking Machines, Army High Performance Com­ puting Research Center, and Argonne National Laboratory. In addition, the NSF sponsored attendance of thirteen graduate students from universities in the United States and abro...

  2. Conference Trends in Logic XI

    CERN Document Server

    Wansing, Heinrich; Willkommen, Caroline; Recent Trends in Philosophical Logic

    2014-01-01

    This volume presents recent advances in philosophical logic with chapters focusing on non-classical logics, including paraconsistent logics, substructural logics, modal logics of agency and other modal logics. The authors cover themes such as the knowability paradox, tableaux and sequent calculi, natural deduction, definite descriptions, identity, truth, dialetheism, and possible worlds semantics.   The developments presented here focus on challenging problems in the specification of fundamental philosophical notions, as well as presenting new techniques and tools, thereby contributing to the development of the field. Each chapter contains a bibliography, to assist the reader in making connections in the specific areas covered. Thus this work provides both a starting point for further investigations into philosophical logic and an update on advances, techniques and applications in a dynamic field.   The chapters originate from papers presented during the Trends in Logic XI conference at the Ruhr University ...

  3. ATR-FTIR spectroscopic characterization of coexisting carbonate surface complexes on hematite

    Science.gov (United States)

    Bargar, J.R.; Kubicki, J.D.; Reitmeyer, R.; Davis, J.A.

    2005-01-01

    The speciation of carbonate adsorbed to hematite in air-equilibrated aqueous solutions has been studied using ATR-FTIR spectroscopy. Samples were measured over a range of pH conditions, at 0.1 M NaCl and at low ionic strength, and in H2O and D2O solutions to permit a multispecies analysis of the data. Second-derivative analyses and fits to the spectra indicate the presence of two major and two minor surface-bound carbonate species. The two major complexes coexist at near-neutral pH and low ionic strength. One of these two complexes is relatively sensitive to ionic strength, being displaced at 0.1 M NaCl, whereas the other is not. Comparison of experimental to DFT/MO-calculated frequencies suggest these two major species to be (a) a monodentate binuclear inner-sphere carbonate surface complex, and (b) a fully or partially solvated carbonate (CO32-) species that is symmetry broken and appears to reside in the structured vicinal water layers at the hematite-water interface, retained by hydrogen bonding and/or other forces. Minor carbonate complexes include diffuse layer CO32- and an unidentified inner-sphere species. Both of the dominant species observed here are likely to be significant controls of the surface charge and sorptive properties of Fe-oxides. Copyright ?? 2005 Elsevier Ltd.

  4. Reagent-free simultaneous determination of glucose and cholesterol in whole blood by FTIR-ATR

    Science.gov (United States)

    Li, Zhigang; Lv, Hong; Li, Tianhe; Si, Guangyuan; Wang, Qiaoyun; Lv, Jiangtao; Hu, Xiaofei

    2017-05-01

    Reagent-free determination of multiple analytes is an active and promising field of research in clinical analysis. In this work, the determination of glucose and cholesterol in whole blood using Fourier transform infrared (FTIR) spectroscopy equipped with an attenuated total reflectance (ATR) accessory was performed. A comprehensive sample selection rule in multi space based on SPXY was proposed, termed C-SPXY. The core idea is to make full use of different derivative spectra space to construct the calibration set which preserves the more effective information. On this basis, a partial least squares (PLS) regression fusion modeling method was also presented aiming at improving prediction accuracy of glucose and cholesterol concentration in whole blood samples. Compared with other methods based on single spectra space, the proposed fusion model based on multi spectra space C-SPXY method provides smaller RMSEP values. Experimental results demonstrate that the proposed method and model provides superior predictive power and holds a good application prospect in the field of clinical analysis.

  5. Analysis code for medium and small rupture accidents in ATR. LOTRAC/HEATUP

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-08-01

    In the evaluation of thermo-hydraulic and fuel temperature transient changes in the events which are classified in medium and small rupture accidents of reactor coolant loss that is the safety evaluation event of the ATR, the analysis code for synthetic thermo-hydraulic transient change at the time of medium and small ruptures LOTRAC and the detailed analysis code for fuel temperature HEATUP are used, respectively. By using the LOTAC, the thermo-hydraulic behavior of reactor cooling facility and the temperature behavior of fuel at the time of blow-down are analyzed, and also the characteristics of changing reactor thermal output is analyzed, considering the functioning characteristics of emergency core cooling system. Based on the data of thermo-hydraulic behavior obtained by the LOTRAC, the time of beginning the turn-around of fuel cladding tube temperature obtained by the data of ECCS pouring characteristics, the heat transfer rate after the turn-around and so on, the detailed temperature change of fuel elements is analyzed by the HEATUP, and the highest temperature and the amount of oxidation of fuel cladding tubes are determined. The LOTRAC code, the HEATUP code, various analysis models, and rupture simulation experiment are reported. (K.I.)

  6. Tungstate (VI) sorption on hematite: An in situ ATR-FTIR probe on the mechanism.

    Science.gov (United States)

    Rakshit, Sudipta; Sallman, Bryan; Davantés, Athénais; Lefèvre, Grégory

    2017-02-01

    Owing to the suspected toxicity and carcinogenicity of tungstate (VI) oxyanions [i.e. mono tungstate and several polytungstate, generally represented by W (VI)], the environmental fate of W (VI) has been widely studied. Sorption is regarded as a major mechanism by which W (VI) species are retained in the solid/water interface. Iron (hydr)oxides have been considered important environmental sinks for W (VI) species. Here we report sorption mechanisms of W (VI) on a common iron oxide mineral-hematite under environmentally relevant solution properties using in situ attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopic probes. Initial W (VI) loadings varied from 10 to 200 μM at fixed pH values ranged from 4.6 to 8.1. For pH envelop (pHs = 4.6, 5.0, 5.5, 6.0, 6.5, 7.5, and 8.1) experiments, fixed W (VI) concentrations (i.e. 10 & 200 μM) were used to understand the effects of pH. The results indicated that at acidic pH values (pH hematite surface and the strength of the interaction increases with decreasing pH. In addition, initial W (VI) concentration affected the sorption mechanisms of W (VI) on hematite. Our study will aid the molecular level understanding of W (VI) retention on iron oxide surfaces. Copyright © 2016 Elsevier Ltd. All rights reserved.

  7. Effects of Near Infrared Radiation on DNA. DLS and ATR-FTIR Study.

    Science.gov (United States)

    Szymborska-Małek, Katarzyna; Komorowska, Małgorzata; Gąsior-Głogowska, Marlena

    2018-01-05

    We presume that the primary effect of Near Infrared (NIR) radiation on aqueous solutions of biological molecules concerns modification of hydrogen bonded structures mainly the global and the hydration shell water molecules. Since water has a significant influence on the DNA structure, we expect that the thermal stability of DNA could be modified by NIR radiation. The herring sperm DNA was exposed to NIR radiation (700-1100nm) for 5, 10, and 20min periods. The temperature dependent infrared measurements were done for the thin films formed on the diamond ATR crystal from evaporated DNA solutions exposed and unexposed to NIR radiation. For the NIR-treated samples (at room temperature) the B form was better conserved than in the control sample independently of the irradiation period. Above 50°C a considerable increase in the A form was only observed for 10min NIR exposed samples. The hydrodynamic radius, (Rh), studied by the dynamic light scattering, showed drastic decrease with the increasing irradiation time. Principal components analysis (PCA) allowed to detect the spectral features correlated with the NIR effect and thermal stability of the DNA films. Obtained results strongly support the idea that the photoionization of water by NIR radiation in presence of DNA molecules is the main factor influencing on its physicochemical properties. Copyright © 2017 Elsevier B.V. All rights reserved.

  8. ATR discrimination-SNR for HRR assuming χ2 model of RCS variability

    Science.gov (United States)

    Holt, Craig R.; Schmidt, Steven L.; Attili, Joseph B.

    2001-10-01

    A discrimination SNR for predicting classification performance is developed as an analogy to the RADAR equation that is used to predict detection performance. It assumes a statistical model for the target radar cross-section (RCS) and that the resulting likelihood classifier is employed. The relationship between the probability of classification errors and the dB value of the discrimination SNR is obtained. A specific form for the likelihood classifier and the discrimination SNR is developed assuming that the variability of the target RCS is described by a (chi) 2 - distribution. The form of this (chi) 2 - based classifier is novel and significantly different from the more common Gaussian based mean-square-error classifier. It is shown that the discrimination SNR has an intuitive interpretation in terms of the number of radar samples, the average contrast between targets and the contrast-noise. The use of this tool is illustrated using compact range High Range Resolution (HRR) Doppler measurements from the U.S. Army National Ground Intelligence Center (NGIC). The sensitivity of ATR performance to radar parameters is quantified using the discrimination SNR with gains measured in meaningful dB units.

  9. Quantitative monitoring of membrane permeation via in-situ ATR FT-IR spectroscopy

    Science.gov (United States)

    Beckingham, Bryan; Miller, Daniel

    Ion conducting membranes are of interest for various energy applications including fuel cells and artificial photosynthesis systems. Within the context of artificial photosynthesis, membranes are desired that facilitate the ion transport necessary to feed the electrochemical reactions while meeting various additional selectivity and permeability demands depending on the CO2 reduction products. Herein, we demonstrate the use of in-situ ATR FT-IR spectroscopy to quantitatively resolve the concentration of single and multicomponent mixtures of various CO2 reduction products including methanol, formate and acetate. We then apply this methodology to the in-situ monitoring of the permeation of single and multicomponent mixtures across commercially available membranes. Membrane permeabilities and selectivities calculated from the single component time-resolved concentration curves are compared to the multicomponent permeation experiments. This material is based upon work performed at the Joint Center for Artificial Photosynthesis, a DOE Energy Innovation Hub, supported through the Office of Science of the U.S. Department of Energy under Award Number DE-SC000493.

  10. Probing the Mec1ATR Checkpoint Activation Mechanism with Small Peptides.

    Science.gov (United States)

    Wanrooij, Paulina H; Tannous, Elias; Kumar, Sandeep; Navadgi-Patil, Vasundhara M; Burgers, Peter M

    2016-01-01

    Yeast Mec1, the ortholog of human ATR, is the apical protein kinase that initiates the cell cycle checkpoint in response to DNA damage and replication stress. The basal activity of Mec1 kinase is activated by cell cycle phase-specific activators. Three distinct activators stimulate Mec1 kinase using an intrinsically disordered domain of the protein. These are the Ddc1 subunit of the 9-1-1 checkpoint clamp (ortholog of human and Schizosaccharomyces pombe Rad9), the replication initiator Dpb11 (ortholog of human TopBP1 and S. pombe Cut5), and the multifunctional nuclease/helicase Dna2. Here, we use small peptides to determine the requirements for Mec1 activation. For Ddc1, we identify two essential aromatic amino acids in a hydrophobic environment that when fused together are proficient activators. Using this increased insight, we have been able to identify homologous motifs in S. pombe Rad9 that can activate Mec1. Furthermore, we show that a 9-amino acid Dna2-based peptide is sufficient for Mec1 activation. Studies with mutant activators suggest that binding of an activator to Mec1 is a two-step process, the first step involving the obligatory binding of essential aromatic amino acids to Mec1, followed by an enhancement in binding energy through interactions with neighboring sequences. © 2016 by The American Society for Biochemistry and Molecular Biology, Inc.

  11. S phase block following MEC1ATR inactivation occurs without severe dNTP depletion

    Directory of Open Access Journals (Sweden)

    Caroline Earp

    2015-12-01

    Full Text Available Inactivation of Mec1, the budding yeast ATR, results in a permanent S phase arrest followed by chromosome breakage and cell death during G2/M. The S phase arrest is proposed to stem from a defect in Mec1-mediated degradation of Sml1, a conserved inhibitor of ribonucleotide reductase (RNR, causing a severe depletion in cellular dNTP pools. Here, the casual link between the S phase arrest, Sml1, and dNTP-levels is examined using a temperature sensitive mec1 mutant. In addition to S phase arrest, thermal inactivation of Mec1 leads to constitutively high levels of Sml1 and an S phase arrest. Expression of a novel suppressor, GIS2, a conserved mRNA binding zinc finger protein, rescues the arrest without down-regulating Sml1 levels. The dNTP pool in mec1 is reduced by ∼17% and GIS2 expression restores it, but only partially, to ∼93% of a control. We infer that the permanent S phase block following Mec1 inactivation can be uncoupled from its role in Sml1 down-regulation. Furthermore, unexpectedly modest effects of mec1 and GIS2 on dNTP levels suggest that the S phase arrest is unlikely to result from a severe depletion of dNTP pool as assumed, but a heightened sensitivity to small changes in its availability.

  12. Effects of Near Infrared Radiation on DNA. DLS and ATR-FTIR Study

    Science.gov (United States)

    Szymborska-Małek, Katarzyna; Komorowska, Małgorzata; Gąsior-Głogowska, Marlena

    2018-01-01

    We presume that the primary effect of Near Infrared (NIR) radiation on aqueous solutions of biological molecules concerns modification of hydrogen bonded structures mainly the global and the hydration shell water molecules. Since water has a significant influence on the DNA structure, we expect that the thermal stability of DNA could be modified by NIR radiation. The herring sperm DNA was exposed to NIR radiation (700-1100 nm) for 5, 10, and 20 min periods. The temperature dependent infrared measurements were done for the thin films formed on the diamond ATR crystal from evaporated DNA solutions exposed and unexposed to NIR radiation. For the NIR-treated samples (at room temperature) the B form was better conserved than in the control sample independently of the irradiation period. Above 50 °C a considerable increase in the A form was only observed for 10 min NIR exposed samples. The hydrodynamic radius, (Rh), studied by the dynamic light scattering, showed drastic decrease with the increasing irradiation time. Principal components analysis (PCA) allowed to detect the spectral features correlated with the NIR effect and thermal stability of the DNA films. Obtained results strongly support the idea that the photoionization of water by NIR radiation in presence of DNA molecules is the main factor influencing on its physicochemical properties.

  13. A further insight into the adsorption mechanism of protein on hydroxyapatite by FTIR-ATR spectrometry

    Science.gov (United States)

    Lin, Zhongyu; Hu, Ren; Zhou, Jianzhang; Ye, Yiwen; Xu, Zhaoxi; Lin, Changjian

    2017-02-01

    The adsorption mechanism of bovine serum albumin (BSA) on hydroxyapatite (HA) for different time intervals has been studied by Fourier transform infrared (FTIR)-attenuated total internal reflectance (ATR) spectrometry in this paper. The difference spectra obtained in HA and BSA frequency regions demonstrate that the binding of Pdbnd O, from the phosphate (PO43 -) of HA, to the hydrogen of methyl (- CH3), methene (- CH2) and amideII (- CNH) in the protein appears to be much faster and stronger than that of the Psbnd O group. In addition, Ca2 + must serve as a key role in the interaction of BSA with HA. The binding of Ca2 + to the oxygen of the peptide bond seems to induce a significant reconformation of polypeptide backbones from β-pleated sheet to α-helix and β-turn of helical circles. This alteration seems to have been accompanied by much hydrogen of polypeptides driven to bind PO43 - and OH- of the HA actively and much -C = O and Hsbnd Nsbnd groups of the peptide bond freed from inter-chain hydrogen bonding to react on Ca2 + and combine strongly with the HA surface. This might be well expected to promote the HA biomineralization.

  14. In situ ATR-FTIR study of the early stages of fly ash geopolymer gel formation.

    Science.gov (United States)

    Rees, Catherine A; Provis, John L; Lukey, Grant C; van Deventer, Jannie S J

    2007-08-14

    The kinetics of geopolymer formation are monitored using a novel in situ attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopic technique. Reaction rates are determined from the intensity variation of the bands related to the geopolymer gel network and the unreacted fly ash particles. Comparison with deuterated geopolymer samples provides critical information regarding peak assignments. An initial induction (lag) period is observed to occur for hydroxide-activated geopolymers, followed by gel evolution according to an approximately linear reaction profile. The length of the lag period is reduced by increasing the concentration of NaOH. An increase in the rate of network formation also occurs with increasing NaOH concentration up to a maximum point, beyond which an increased NaOH concentration leads to a reduced rate of network formation. This trend is attributed to the competing effects of increased alkalinity and stronger ion pairing with an increase in NaOH concentration. In situ analysis also shows that the rate of fly ash dissolution is similar for all moderate- to high-alkali geopolymer slurries, which is attributed to the very highly water-deficient nature of these systems and is contrary to predictions from classical glass dissolution chemistry. This provides for the first time detailed kinetic information describing fly ash geopolymer formation kinetics.

  15. EVOLVE 2014 International Conference

    CERN Document Server

    Tantar, Emilia; Sun, Jian-Qiao; Zhang, Wei; Ding, Qian; Schütze, Oliver; Emmerich, Michael; Legrand, Pierrick; Moral, Pierre; Coello, Carlos

    2014-01-01

    This volume encloses research articles that were presented at the EVOLVE 2014 International Conference in Beijing, China, July 1–4, 2014.The book gathers contributions that emerged from the conference tracks, ranging from probability to set oriented numerics and evolutionary computation; all complemented by the bridging purpose of the conference, e.g. Complex Networks and Landscape Analysis, or by the more application oriented perspective. The novelty of the volume, when considering the EVOLVE series, comes from targeting also the practitioner’s view. This is supported by the Machine Learning Applied to Networks and Practical Aspects of Evolutionary Algorithms tracks, providing surveys on new application areas, as in the networking area and useful insights in the development of evolutionary techniques, from a practitioner’s perspective. Complementary to these directions, the conference tracks supporting the volume, follow on the individual advancements of the subareas constituting the scope of the confe...

  16. DNA sequencing conference, 2

    Energy Technology Data Exchange (ETDEWEB)

    Cook-Deegan, R.M. [Georgetown Univ., Kennedy Inst. of Ethics, Washington, DC (United States); Venter, J.C. [National Inst. of Neurological Disorders and Strokes, Bethesda, MD (United States); Gilbert, W. [Harvard Univ., Cambridge, MA (United States); Mulligan, J. [Stanford Univ., CA (United States); Mansfield, B.K. [Oak Ridge National Lab., TN (United States)

    1991-06-19

    This conference focused on DNA sequencing, genetic linkage mapping, physical mapping, informatics and bioethics. Several were used to study this sequencing and mapping. This article also discusses computer hardware and software aiding in the mapping of genes.

  17. The learning conference

    DEFF Research Database (Denmark)

    Ravn, Ib

    little support amongst serious students of learning. The professional conference as a forum for knowledge sharing is in dire need of a new learning theory and a more enlightened practice. The notion of human flourishing is offered as basis for theory, and four simple design principles for the so-called......The typical one-day conference attended by managers or professionals in search of inspiration is packed with PowerPoint presentations and offers little opportunity for involvement or knowledge sharing. Behind the conventional conference format lurks the transfer model of learning, which finds...... “learning conference” are proposed: People go to conferences to 1. get concise input, 2. interpret it in the light of their ongoing concerns, 3. talk about their current projects and 4. meet the other attendees and be inspired by them. Six practical techniques that induce attendees to do these things...

  18. Photos of the conference

    Directory of Open Access Journals (Sweden)

    Birgitta Åhman

    1984-05-01

    Full Text Available Birgitta  Åhman is the photographer of the series of pictures from the conference, also for the cover photo of the full paper edition showing Kongsvold Mountain Hut and Biological Station.

  19. Ranking Operations Management conferences

    NARCIS (Netherlands)

    Steenhuis, H.J.; de Bruijn, E.J.; Gupta, Sushil; Laptaned, U

    2007-01-01

    Several publications have appeared in the field of Operations Management which rank Operations Management related journals. Several ranking systems exist for journals based on , for example, perceived relevance and quality, citation, and author affiliation. Many academics also publish at conferences

  20. Final report on the Copper Mountain conference on multigrid methods

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-10-01

    The Copper Mountain Conference on Multigrid Methods was held on April 6-11, 1997. It took the same format used in the previous Copper Mountain Conferences on Multigrid Method conferences. Over 87 mathematicians from all over the world attended the meeting. 56 half-hour talks on current research topics were presented. Talks with similar content were organized into sessions. Session topics included: fluids; domain decomposition; iterative methods; basics; adaptive methods; non-linear filtering; CFD; applications; transport; algebraic solvers; supercomputing; and student paper winners.

  1. Application of FTIR-ATR Spectroscopy to Determine the Extent of Lipid Peroxidation in Plasma during Haemodialysis.

    Science.gov (United States)

    Oleszko, Adam; Olsztyńska-Janus, Sylwia; Walski, Tomasz; Grzeszczuk-Kuć, Karolina; Bujok, Jolanta; Gałecka, Katarzyna; Czerski, Albert; Witkiewicz, Wojciech; Komorowska, Małgorzata

    2015-01-01

    During a haemodialysis (HD), because of the contact of blood with the surface of the dialyser, the immune system becomes activated and reactive oxygen species (ROS) are released into plasma. Particularly exposed to the ROS are lipids and proteins contained in plasma, which undergo peroxidation. The main breakdown product of oxidized lipids is the malondialdehyde (MDA). A common method for measuring the concentration of MDA is a thiobarbituric acid reactive substances (TBARS) method. Despite the formation of MDA in plasma during HD, its concentration decreases because it is removed from the blood in the dialyser. Therefore, this research proposes the Fourier Transform Infrared Attenuated Total Reflectance (FTIR-ATR) spectroscopy, which enables determination of primary peroxidation products. We examined the influence of the amount of hydrogen peroxide added to lipid suspension that was earlier extracted from plasma specimen on lipid peroxidation with use of TBARS and FTIR-ATR methods. Linear correlation between these methods was shown. The proposed method was effective during the evaluation of changes in the extent of lipid peroxidation in plasma during a haemodialysis in sheep. A measurement using the FTIR-ATR showed an increase in plasma lipid peroxidation after 15 and 240 minutes of treatment, while the TBARS concentration was respectively lower.

  2. The ATM and ATR inhibitors CGK733 and caffeine suppress cyclin D1 levels and inhibit cell proliferation

    Directory of Open Access Journals (Sweden)

    Sunnerhagen Per

    2009-11-01

    Full Text Available Abstract The ataxia telangiectasia mutated (ATM and the ATM- related (ATR kinases play a central role in facilitating the resistance of cancer cells to genotoxic treatment regimens. The components of the ATM and ATR regulated signaling pathways thus provide attractive pharmacological targets, since their inhibition enhances cellular sensitivity to chemo- and radiotherapy. Caffeine as well as more specific inhibitors of ATM (KU55933 or ATM and ATR (CGK733 have recently been shown to induce cell death in drug-induced senescent tumor cells. Addition of these agents to cancer cells previously rendered senescent by exposure to genotoxins suppressed the ATM mediated p21 expression required for the survival of these cells. The precise molecular pharmacology of these agents however, is not well characterized. Herein, we report that caffeine, CGK733, and to a lesser extent KU55933, inhibit the proliferation of otherwise untreated human cancer and non-transformed mouse fibroblast cell lines. Exposure of human cancer cell lines to caffeine and CGK733 was associated with a rapid decline in cyclin D1 protein levels and a reduction in the levels of both phosphorylated and total retinoblastoma protein (RB. Our studies suggest that observations based on the effects of these compounds on cell proliferation and survival must be interpreted with caution. The differential effects of caffeine/CGK733 and KU55933 on cyclin D1 protein levels suggest that these agents will exhibit dissimilar molecular pharmacological profiles.

  3. Validation of ATR FT-IR to identify polymers of plastic marine debris, including those ingested by marine organisms.

    Science.gov (United States)

    Jung, Melissa R; Horgen, F David; Orski, Sara V; Rodriguez C, Viviana; Beers, Kathryn L; Balazs, George H; Jones, T Todd; Work, Thierry M; Brignac, Kayla C; Royer, Sarah-Jeanne; Hyrenbach, K David; Jensen, Brenda A; Lynch, Jennifer M

    2018-02-01

    Polymer identification of plastic marine debris can help identify its sources, degradation, and fate. We optimized and validated a fast, simple, and accessible technique, attenuated total reflectance Fourier transform infrared spectroscopy (ATR FT-IR), to identify polymers contained in plastic ingested by sea turtles. Spectra of consumer good items with known resin identification codes #1-6 and several #7 plastics were compared to standard and raw manufactured polymers. High temperature size exclusion chromatography measurements confirmed ATR FT-IR could differentiate these polymers. High-density (HDPE) and low-density polyethylene (LDPE) discrimination is challenging but a clear step-by-step guide is provided that identified 78% of ingested PE samples. The optimal cleaning methods consisted of wiping ingested pieces with water or cutting. Of 828 ingested plastics pieces from 50 Pacific sea turtles, 96% were identified by ATR FT-IR as HDPE, LDPE, unknown PE, polypropylene (PP), PE and PP mixtures, polystyrene, polyvinyl chloride, and nylon. Published by Elsevier Ltd.

  4. Rapid detection of gelatin in dental materials using attenuated total reflection fourier transform infrared spectroscopy (ATR-FTIR)

    Science.gov (United States)

    Irfanita, N.; Jaswir, I.; Mirghani, M. E. S.; Sukmasari, S.; Ardini, Y. D.; Lestari, W.

    2017-08-01

    The presence of gelatin is not limited to food products but has also been found in pharmaceuticals. Most dental materials available in Malaysia are imported from other countries and might contain gelatin which is a protein derived either from porcine, bovine or other animal sources. Authentication of gelatin is crucial due to religious and health concerns. Therefore, this study aimed to detect gelatin in dental materials using ATR-FTIR. Forty two samples of dental material were purchased from dental suppliers and detection was done using ATR-FTIR. The spectrum from each sample was compared against standard bovine and porcine gelatin. Experimental dental paste containing bovine and porcine gelatin at concentrations of 5, 10, 15 and 20% were also prepared for quantification analysis. The results showed that gelatin was present in nine out of forty two samples of dental materials but the species of origin was not confirmed. Meanwhile, in the experimental bovine and porcine dental paste, it was seen that as the concentration increased, the intensity of the absorption of Amide group also increased. Thus, ATR-FTIR can be utilized as a reliable tool to detect gelatin in dental materials and other pharmaceuticals.

  5. ATR-FT-IR spectroscopy in the region of 550-230 cm -1 for identification of inorganic pigments

    Science.gov (United States)

    Vahur, Signe; Teearu, Anu; Leito, Ivo

    2010-03-01

    A comprehensive study of ATR-FT-IR spectra of 40 inorganic pigments of different colours widely used in historical paintings has been carried out in the low wave number spectral range (550-230 cm -1). The infrared spectra were recorded from mixtures of pigment and linseed oil. It is demonstrated that this spectral range - essentially devoid of absorption peaks of the common binder materials - can be well used for identification of inorganic pigments in paint samples thereby markedly extending the possibilities of pigment identification/confirmation by ATR-IR spectroscopy into the realm of pigments having no absorptions in the mid-IR region. In some cases the method can be used alone for pigment identification and in many cases it provides useful additional evidence for pigment identification using other instrumental techniques (electron microprobe analysis, XRF, optical microscopy). Together with earlier work this study provides a comprehensive overview of the pigment identification possibilities using ATR-FT-IR as well as a collection of reference spectra and is expected to be a useful reference for conservation practitioners.

  6. Structural transformation of synthetic hydroxyapatite under simulated in vivo conditions studied with ATR-FTIR spectroscopic imaging

    Science.gov (United States)

    Sroka-Bartnicka, Anna; Borkowski, Leszek; Ginalska, Grazyna; Ślósarczyk, Anna; Kazarian, Sergei G.

    2017-01-01

    Hydroxyapatite and carbonate-substituted hydroxyapatite are widely used in bone tissue engineering and regenerative medicine. Both apatite materials were embedded into recently developed ceramic/polymer composites, subjected to Simulated Body Fluid (SBF) for 30 days and characterized using ATR-FTIR spectroscopic imaging to assess their behaviour and structures. The specific aim was to detect the transition phases between both types of hydroxyapatite during the test and to analyze the surface modification caused by SBF. ATR-FTIR spectroscopic imaging was successfully applied to characterise changes in the hydroxyapatite lattice due to the elastic properties of the scaffolds. It was observed that SBF treatment caused a replacement of phosphates in the lattice of non-substituted hydroxyapatite by carbonate ions. A detailed study excluded the formation of pure A type carbonate apatite. In turn, CO32- content in synthetic carbonate-substituted hydroxyapatite decreased. The usefulness of ATR-FTIR spectroscopic imaging studies in the evaluation of elastic and porous β-glucan hydroxyapatite composites has been demonstrated.

  7. HMGA2 Inhibits Apoptosis through Interaction with ATR-CHK1 Signaling Complex in Human Cancer Cells

    Directory of Open Access Journals (Sweden)

    Suchitra Natarajan

    2013-03-01

    Full Text Available The non-histone chromatin binding protein high mobility group AT-hook 2 (HMGA2 is expressed in stem cells and many cancer cells, including tumor initiating cells, but not translated in normal human somatic cells. The presence of HMGA2 is correlated with advanced neoplastic disease and poor prognosis for patients. We had previously demonstrated a role of HMGA2 in DNA repair pathways. In the present study, we employed different human tumor cell models with endogenous and exogenous expression of HMGA2 and show that upon DNA damage, the presence of HMGA2 caused an increased and sustained phosphorylation of the ataxia telangiectasia and Rad3-related kinase (ATR and its downstream target checkpoint kinase 1 (CHK1. The presence of activated pCHK1Ser296 coincided with prolonged G2/M block and increased tumor cell survival, which was enhanced further in the presence of HMGA2. Our study, thus, identifies a novel relationship between the ATR-CHK1 DNA damage response pathway and HMGA2, which may support the DNA repair function of HMGA2 in cancer cells. Furthermore, our data provide a rationale for the use of inhibitors to ATR or CHK1 and HMGA2 in the treatment of HMGA2-positive human cancer cells.

  8. Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes

    Energy Technology Data Exchange (ETDEWEB)

    Takai, Hiroyuki; Xie, Yihu; de Lange, Titia; Pavletich, Nikola P. (Rockefeller); (SKI)

    2010-09-20

    We reported previously that the stability of all mammalian phosphatidylinositol 3-kinase-related protein kinases (PIKKs) depends on their interaction with Tel2, the ortholog of yeast Tel2 and Caenorhabditis elegans Clk-2. Here we provide evidence that Tel2 acts with Hsp90 in the maturation of PIKK complexes. Quantitative immunoblotting showed that the abundance of Tel2 is low compared with the PIKKs, and Tel2 preferentially bound newly synthesized ATM, ATR, mTOR, and DNA-PKcs. Tel2 complexes contained, in addition to Tti1-Tti2, the Hsp90 chaperone, and inhibition of Hsp90 interfered with the interaction of Tel2 with the PIKKs. Analysis of in vivo labeled nascent protein complexes showed that Tel2 and Hsp90 mediate the formation of the mTOR TORC1 and TORC2 complexes and the association of ATR with ATRIP. The structure of yeast Tel2, reported here, shows that Tel2 consists of HEAT-like helical repeats that assemble into two separate {alpha}-solenoids. Through mutagenesis, we identify a surface patch of conserved residues involved in binding to the Tti1-Tti2 complex in vitro. In vivo, mutation of this conserved patch affects cell growth, levels of PIKKs, and ATM/ATR-mediated checkpoint signaling, highlighting the importance of Tti1-Tti2 binding to the function of Tel2. Taken together, our data suggest that the Tel2-Tti1-Tti2 complex is a PIKK-specific cochaperone for Hsp90.

  9. AZD6738, A Novel Oral Inhibitor of ATR, Induces Synthetic Lethality with ATM Deficiency in Gastric Cancer Cells.

    Science.gov (United States)

    Min, Ahrum; Im, Seock-Ah; Jang, Hyemin; Kim, Seongyeong; Lee, Miso; Kim, Debora Keunyoung; Yang, Yaewon; Kim, Hee-Jun; Lee, Kyung-Hun; Kim, Jin Won; Kim, Tae-Yong; Oh, Do-Youn; Brown, Jeff; Lau, Alan; O'Connor, Mark J; Bang, Yung-Jue

    2017-04-01

    Ataxia telangiectasia and Rad3-related (ATR) can be considered an attractive target for cancer treatment due to its deleterious effect on cancer cells harboring a homologous recombination defect. The aim of this study was to investigate the potential use of the ATR inhibitor, AZD6738, to treat gastric cancer.In SNU-601 cells with dysfunctional ATM, AZD6738 treatment led to an accumulation of DNA damage due to dysfunctional RAD51 foci formation, S phase arrest, and caspase 3-dependent apoptosis. In contrast, SNU-484 cells with functional ATM were not sensitive to AZD6738. Inhibition of ATM in SNU-484 cells enhanced AZD6738 sensitivity to a level comparable with that observed in SNU-601 cells, showing that activation of the ATM-Chk2 signaling pathway attenuates AZD6738 sensitivity. In addition, decreased HDAC1 expression was found to be associated with ATM inactivation in SNU-601 cells, demonstrating the interaction between HDAC1 and ATM can affect sensitivity to AZD6738. Furthermore, in an in vivo tumor xenograft mouse model, AZD6738 significantly suppressed tumor growth and increased apoptosis.These findings suggest synthetic lethality between ATR inhibition and ATM deficiency in gastric cancer cells. Further clinical studies on the interaction between AZD 6738 and ATM deficiency are warranted to develop novel treatment strategies for gastric cancer. Mol Cancer Ther; 16(4); 566-77. ©2017 AACR. ©2017 American Association for Cancer Research.

  10. Improving precursor adsorption characteristics in ATR-FTIR spectroscopy with a ZrO{sub 2} nanoparticle coating

    Energy Technology Data Exchange (ETDEWEB)

    Park, Jaeseo [Korea Research Institute of Standards and Science, Center for Vacuum Technology (Korea, Republic of); Mun, Jihun [University of Science and Technology, Department of Advanced Device Technology (Korea, Republic of); Shin, Jae-Soo; Kim, Jongho; Park, Hee Jung [Daejeon University, Department of Advanced Materials Engineering (Korea, Republic of); Kang, Sang-Woo, E-mail: swkang@kriss.re.kr [Korea Research Institute of Standards and Science, Center for Vacuum Technology (Korea, Republic of)

    2017-02-15

    Nanoparticles were applied to a crystal surface to increase its precursor adsorption efficiency in an attenuated total reflection Fourier transform infrared (ATR-FTIR) spectrometer. Nanoparticles with varying dispersion stabilities were employed and the resulting precursor adsorption characteristics were assessed. The size of the nanoparticles was <100 nm (TEM). In order to vary the dispersion stability, ZrO{sub 2} nanoparticles were dispersed in aqueous solutions of different pH. The ZrO{sub 2} dispersion solutions were analyzed using scanning electron microscopy (SEM) while particle distribution measurements were analyzed using electrophoretic light scattering (ELS) and dynamic light scattering (DLS) techniques. ZrO{sub 2} nanoparticles dispersed in solutions of pH 3 and 11 exhibited the most stable zeta potentials (≥+30 or ≤−30 mV); these observations were confirmed by SEM analysis and particle distribution measurements. Hexamethyldisilazane (HMDS) was used as a precursor for ATR-FTIR spectroscopy. Consequently, when ZrO{sub 2} nanoparticle solutions with the best dispersion stabilities (pH 3 and 11) were applied to the adsorption crystal surface, the measurement efficiency of ATR-FTIR spectroscopy improved by ∼200 and 300%, respectively.

  11. Targeting the kinase activities of ATR and ATM exhibits antitumoral activity in mouse models of MLL-rearranged AML.

    Science.gov (United States)

    Morgado-Palacin, Isabel; Day, Amanda; Murga, Matilde; Lafarga, Vanesa; Anton, Marta Elena; Tubbs, Anthony; Chen, Hua Tang; Ergan, Aysegul; Anderson, Rhonda; Bhandoola, Avinash; Pike, Kurt G; Barlaam, Bernard; Cadogan, Elaine; Wang, Xi; Pierce, Andrew J; Hubbard, Chad; Armstrong, Scott A; Nussenzweig, André; Fernandez-Capetillo, Oscar

    2016-09-13

    Among the various subtypes of acute myeloid leukemia (AML), those with chromosomal rearrangements of the MLL oncogene (AML-MLL) have a poor prognosis. AML-MLL tumor cells are resistant to current genotoxic therapies because of an attenuated response by p53, a protein that induces cell cycle arrest and apoptosis in response to DNA damage. In addition to chemicals that damage DNA, efforts have focused on targeting DNA repair enzymes as a general chemotherapeutic approach to cancer treatment. Here, we found that inhibition of the kinase ATR, which is the primary sensor of DNA replication stress, induced chromosomal breakage and death of mouse AML(MLL) cells (with an MLL-ENL fusion and a constitutively active N-RAS independently of p53. Moreover, ATR inhibition as a single agent exhibited antitumoral activity, both reducing tumor burden after establishment and preventing tumors from growing, in an immunocompetent allograft mouse model of AML(MLL) and in xenografts of a human AML-MLL cell line. We also found that inhibition of ATM, a kinase that senses DNA double-strand breaks, also promoted the survival of the AML(MLL) mice. Collectively, these data indicated that ATR or ATM inhibition represent potential therapeutic strategies for the treatment of AML, especially MLL-driven leukemias. Copyright © 2016, American Association for the Advancement of Science.

  12. 2nd SUMO Conference

    CERN Document Server

    Weber, Melanie

    2015-01-01

    This contributed volume contains the conference proceedings of the Simulation of Urban Mobility (SUMO) conference 2014, Berlin. The included research papers cover a wide range of topics in traffic planning and simulation, including open data, vehicular communication, e-mobility, urban mobility, multimodal traffic as well as usage approaches. The target audience primarily comprises researchers and experts in the field, but the book may also be beneficial for graduate students.  

  13. Multiphoton processes: conference proceedings

    Energy Technology Data Exchange (ETDEWEB)

    Lambropoulos, P.; Smith, S.J. (eds.)

    1984-01-01

    The chapters of this volume represent the invited papers delivered at the conference. They are arranged according to thermatic proximity beginning with atoms and continuing with molecules and surfaces. Section headings include multiphoton processes in atoms, field fluctuations and collisions in multiphoton process, and multiphoton processes in molecules and surfaces. Abstracts of individual items from the conference were prepared separately for the data base. (GHT)

  14. Attenuated Total Reflection Fourier Transform Infrared (ATR FT-IR) for Rapid Determination of Microbial Cell Lipid Content: Correlation with Gas Chromatography-Mass Spectrometry (GC-MS).

    Science.gov (United States)

    Millan-Oropeza, Aaron; Rebois, Rolando; David, Michelle; Moussa, Fathi; Dazzi, Alexandre; Bleton, Jean; Virolle, Marie-Joelle; Deniset-Besseau, Ariane

    2017-10-01

    There is a growing interest worldwide for the production of renewable oil without mobilizing agriculture lands; fast and reliable methods are needed to identify highly oleaginous microorganisms of potential industrial interest. The aim of this study was to demonstrate the relevance of attenuated total reflection (ATR) spectroscopy to achieve this goal. To do so, the total lipid content of lyophilized samples of five Streptomyces strains with varying lipid content was assessed with two classical quantitative but time-consuming methods, gas chromatography-mass spectrometry (GC-MS) and ATR Fourier transform infrared (ATR FT-IR) spectroscopy in transmission mode with KBr pellets and the fast ATR method, often questioned for its lack of reliability. A linear correlation between these three methods was demonstrated allowing the establishment of equations to convert ATR values expressed as CO/amide I ratio, into micrograms of lipid per milligram of biomass. The ATR method proved to be as reliable and quantitative as the classical GC-MS and FT-IR in transmission mode methods but faster and more reproducible than the latter since it involves far less manipulation for sample preparation than the two others. Attenuated total reflection could be regarded as an efficient fast screening method to identify natural or genetically modified oleaginous microorganisms by the scientific community working in the field of bio-lipids.

  15. Radioresistance of chordoma cells is associated with the ATM/ATR pathway, in which RAD51 serves as an important downstream effector.

    Science.gov (United States)

    Zhang, Chao; Wang, Bing; Li, Lei; Li, Yawei; Li, Pengzhi; Lv, Guohua

    2017-09-01

    Surgery followed by radiotherapy is the standard treatment for chordomas, which are a rare but low-grade type of bone cancer arising from remnants of the embryonic notochord. However, disease recurrence following radiotherapy is common, most likely due to endogenous DNA repair mechanisms that promote cell survival upon radiation strikes. The ataxia telangiectasia mutated/ataxia telangiectasia mutated and Rad3 related (ATM/ATR)-mediated pathway has a critical role in DNA repair mechanisms; however, it has rarely been investigated in chordomas. In the present study, the expression of signal molecules related to the ATM/ATR pathway in chordoma tissues and adjacent normal tissues were initially examined using immunohistochemistry and western blot analysis. Chordoma U-CH1 and U-CH2 cells were subsequently used to investigate cell responses to ionizing radiation and the potential protective actions mediated by the ATM/ATR pathway. Phosphorylated (p)-ATM, p-ATR, γ-H2A histone family, member X (H2AX) and RAD51 were significantly upregulated in chordoma tissues relative to adjacent normal tissues (PATM, γ-H2AX and RAD51 expression in U-CH1 cells (PATM, p-ATR and RAD51 levels in U-CH2 cells (PATM/ATR pathway, in which RAD51 serves as an important downstream effector. Thus, RAD51 presents a promising therapeutic target for improving the outcome of radiotherapy treatment in chordomas.

  16. Dual inhibition of ATR and ATM potentiates the activity of trabectedin and lurbinectedin by perturbing the DNA damage response and homologous recombination repair.

    Science.gov (United States)

    Lima, Michelle; Bouzid, Hana; Soares, Daniele G; Selle, Frédéric; Morel, Claire; Galmarini, Carlos M; Henriques, João A P; Larsen, Annette K; Escargueil, Alexandre E

    2016-05-03

    Trabectedin (Yondelis®, ecteinascidin-743, ET-743) is a marine-derived natural product approved for treatment of advanced soft tissue sarcoma and relapsed platinum-sensitive ovarian cancer. Lurbinectedin is a novel anticancer agent structurally related to trabectedin. Both ecteinascidins generate DNA double-strand breaks that are processed through homologous recombination repair (HRR), thereby rendering HRR-deficient cells particularly sensitive. We here characterize the DNA damage response (DDR) to trabectedin and lurbinectedin in HeLa cells. Our results show that both compounds activate the ATM/Chk2 (ataxia-telangiectasia mutated/checkpoint kinase 2) and ATR/Chk1 (ATM and RAD3-related/checkpoint kinase 1) pathways. Interestingly, pharmacological inhibition of Chk1/2, ATR or ATM is not accompanied by any significant improvement of the cytotoxic activity of the ecteinascidins while dual inhibition of ATM and ATR strongly potentiates it. Accordingly, concomitant inhibition of both ATR and ATM is an absolute requirement to efficiently block the formation of γ-H2AX, MDC1, BRCA1 and Rad51 foci following exposure to the ecteinascidins. These results are not restricted to HeLa cells, but are shared by cisplatin-sensitive and -resistant ovarian carcinoma cells. Together, our data identify ATR and ATM as central coordinators of the DDR to ecteinascidins and provide a mechanistic rationale for combining these compounds with ATR and ATM inhibitors.

  17. 78 FR 17992 - Preparations for the International Telecommunication Union World Telecommunication Development...

    Science.gov (United States)

    2013-03-25

    ... Preparations for the International Telecommunication Union World Telecommunication Development Conference (ITU... Telecommunication Advisory Committee (ITAC) to review the activities of its ad hoc group for preparations for the ITU World Telecommunication Development Conference (WTDC 2014), as well as preparations for other...

  18. Proceedings of the 7. annual Athabasca oil sands conference : oil sands trade show and conference

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2007-07-01

    The Athabasca Oil Sands Projects are considered a major source energy supply for North America, which means increased commitments from producing companies to improve environmental impact and enhance the technology used for extraction and refining. This annual conference, which was hosted by the world's leading group of experts in the unconventional oil industry, provided a venue to network, do business and discover new strategies and innovations for the industry. The presentations highlighted thermal recovery methods, transportation infrastructure, and government policies designed to ensure project success. The four sessions of the conference were entitled: the oil sands landscape, technology advances; project updates; and, research and development. The conference featured 12 presentations, of which 4 have been catalogued separately for inclusion in this database. tabs., figs.

  19. Virtual Labs and Virtual Worlds

    Science.gov (United States)

    Boehler, Ted

    2006-12-01

    Virtual Labs and Virtual Worlds Coastline Community College has under development several virtual lab simulations and activities that range from biology, to language labs, to virtual discussion environments. Imagine a virtual world that students enter online, by logging onto their computer from home or anywhere they have web access. Upon entering this world they select a personalized identity represented by a digitized character (avatar) that can freely move about, interact with the environment, and communicate with other characters. In these virtual worlds, buildings, gathering places, conference rooms, labs, science rooms, and a variety of other “real world” elements are evident. When characters move about and encounter other people (players) they may freely communicate. They can examine things, manipulate objects, read signs, watch video clips, hear sounds, and jump to other locations. Goals of critical thinking, social interaction, peer collaboration, group support, and enhanced learning can be achieved in surprising new ways with this innovative approach to peer-to-peer communication in a virtual discussion world. In this presentation, short demos will be given of several online learning environments including a virtual biology lab, a marine science module, a Spanish lab, and a virtual discussion world. Coastline College has been a leader in the development of distance learning and media-based education for nearly 30 years and currently offers courses through PDA, Internet, DVD, CD-ROM, TV, and Videoconferencing technologies. Its distance learning program serves over 20,000 students every year. sponsor Jerry Meisner

  20. An Approach for Routine Analytical Detection of Beeswax Adulteration Using FTIR-ATR Spectroscopy

    Directory of Open Access Journals (Sweden)

    Svečnjak Lidija

    2015-12-01

    Full Text Available Although beeswax adulteration represents one of the main beeswax quality issues, there are still no internationally standardised analytical methods for routine quality control. The objective of this study was to establish an analytical procedure suitable for routine detection of beeswax adulteration using FTIR-ATR spectroscopy. For the purpose of this study, reference IR spectra of virgin beeswax, paraffin, and their mixtures containing different proportions of paraffin (5 - 95%, were obtained. Mixtures were used for the establishment of calibration curves. To determine the prediction strength of IR spectral data for the share of paraffin in mixtures, the Partial Least Squares Regression method was used. The same procedure was conducted on beeswax-beef tallow mixtures. The model was validated using comb foundation samples of an unknown chemical background which had been collected from the international market (n = 56. Selected physico-chemical parameters were determined for comparison purposes. Results revealed a strong predictive power (R2 = 0.999 of IR spectra for the paraffin and beef tallow share in beeswax. The results also revealed that the majority of the analysed samples (89% were adulterated with paraffin; only 6 out of 56 (11% samples were identified as virgin beeswax, 28% of the samples exhibited a higher level of paraffin adulteration (>46% of paraffin, while the majority of the analysed samples (50% were found to be adulterated with 5 - 20% of paraffin. These results indicate an urgent need for routine beeswax authenticity control. In this study, we demonstrated that the analytical approach defining the standard curves for particular adulteration levels in beeswax, based on chemometric modelling of specific IR spectral region indicative for adulteration, enables reliable determination of the adulterant proportions in beeswax.

  1. Application of FTIR-ATR spectroscopy coupled with multivariate analysis for rapid estimation of butter adulteration.

    Science.gov (United States)

    Fadzlillah, Nurrulhidayah Ahmad; Rohman, Abdul; Ismail, Amin; Mustafa, Shuhaimi; Khatib, Alfi

    2013-01-01

    In dairy product sector, butter is one of the potential sources of fat soluble vitamins, namely vitamin A, D, E, K; consequently, butter is taken into account as high valuable price from other dairy products. This fact has attracted unscrupulous market players to blind butter with other animal fats to gain economic profit. Animal fats like mutton fat (MF) are potential to be mixed with butter due to the similarity in terms of fatty acid composition. This study focused on the application of FTIR-ATR spectroscopy in conjunction with chemometrics for classification and quantification of MF as adulterant in butter. The FTIR spectral region of 3910-710 cm⁻¹ was used for classification between butter and butter blended with MF at various concentrations with the aid of discriminant analysis (DA). DA is able to classify butter and adulterated butter without any mistakenly grouped. For quantitative analysis, partial least square (PLS) regression was used to develop a calibration model at the frequency regions of 3910-710 cm⁻¹. The equation obtained for the relationship between actual value of MF and FTIR predicted values of MF in PLS calibration model was y = 0.998x + 1.033, with the values of coefficient of determination (R²) and root mean square error of calibration are 0.998 and 0.046% (v/v), respectively. The PLS calibration model was subsequently used for the prediction of independent samples containing butter in the binary mixtures with MF. Using 9 principal components, root mean square error of prediction (RMSEP) is 1.68% (v/v). The results showed that FTIR spectroscopy can be used for the classification and quantification of MF in butter formulation for verification purposes.

  2. 2nd Bozeman Conference

    CERN Document Server

    Lund, John

    1991-01-01

    This volume contains a collection of papers delivered by the partici­ pants at the second Conference on Computation and Control held at Mon­ tana State University in Bozeman, Montana from August 1-7, 1990. The conference, as well as this proceedings, attests to the vitality and cohesion between the control theorist and the numerical analyst that was adver­ tised by the first Conference on Computation and Control in 1988. The proceedings of that initial conference was published by Birkhiiuser Boston as the first volume of this same series entitled Computation and Control, Proceedings of the Bozeman Conference, Bozeman, Montana, 1988. Control theory and numerical analysis are both, by their very nature, interdisciplinary subjects as evidenced by their interaction with other fields of mathematics and engineering. While it is clear that new control or es­ timation algorithms and new feedback design methodologies will need to be implemented computationally, it is likewise clear that new problems in computation...

  3. "Looking over the dunes" : A conference on educating world citizens

    NARCIS (Netherlands)

    Jos Walenkamp

    2013-01-01

    The Research Group International Cooperation investigates the acquisition of international competencies by internships or study abroad, the international competencies of lecturers, the needs and demands for international competencies of alumni and employers and which factors are important to attract

  4. Radical Math: Creating Balance in an Unjust World, Conference Report

    Science.gov (United States)

    Davidson, Jill

    2007-01-01

    Founded in 2006 by Jonathan Osler, Math and Community Organizing teacher at El Puente Academy for Peace and Justice, a public CES high school in Brooklyn, New York, Radical Math is an organization for educators working to integrate issues of political, economic, and social justice into math education. In April 2007, Radical Math cosponsored…

  5. Conferences and Family Reunions

    Directory of Open Access Journals (Sweden)

    Sarah Sutherland

    2012-12-01

    Full Text Available Professional associations and conferences have similarities with and differences from families and family reunions. This comparison can illustrate some ways professional associations can approach the integration of new members and the planning of conferences in order to facilitate membership development and leadership renewal. Unlike family reunions, professional conferences are not closed events that require a shared culture in order to fully participate; they are events that should show the constant change and development of practice that is representative of the profession – for both members and non-members. Some of the topics explored in the article are: making it easy for outsiders to contribute, considering the tastes of new members, making it easy to volunteer in a meaningful way, and remembering who the future of the organization is. These simple considerations will assist in opening professional associations to new participants and help them to maintain their relevance and vitality over time.

  6. PREFACE AND CONFERENCE INFORMATION: Eighth International Conference on Laser Ablation

    Science.gov (United States)

    Hess, Wayne P.; Herman, Peter R.; Bäuerle, Dieter; Koinuma, Hideomi

    2007-04-01

    Laser ablation encompasses a wide range of delicate to extreme light interactions with matter that present considerably challenging problems for scientists to study and understand. At the same time, laser ablation also represents a basic process of significant commercial importance in laser material processing—defining a multi-billion dollar industry today. These topics were widely addressed at the 8th International Conference on Laser Ablation (COLA), held in Banff, Canada on 11-16 September 2005. The meeting took place amongst the majestic and natural beauty of the Canadian Rocky Mountains at The Banff Centre, where delegates enjoyed many inspiring presentations and discussions in a unique campus learning environment. The conference brought together world leading scientists, students and industry representatives to examine the basic science of laser ablation and improve our understanding of the many physical, chemical and/or biological processes driven by the laser. The multi-disciplinary research presented at the meeting underlies some of our most important trends at the forefront of science and technology today that are represented in the papers collected in this volume. Here you will find new processes that are producing novel types of nanostructures and nano-materials with unusual and promising properties. Laser processes are described for delicately manipulating living cells or modifying their internal structure with unprecedented degrees of control and precision. Learn about short-pulse lasers that are driving extreme physical processes on record-fast time scales and opening new directions from material processing applications. The conference papers further highlight forefront application areas in pulsed laser deposition, nanoscience, analytical methods, materials, and microprocessing applications. Laser ablation continues to grow and evolve, touching forefront areas in science and driving new technological trends in laser processing applications. Please

  7. The complexity of DNA double strand break is a crucial factor for activating ATR signaling pathway for G2/M checkpoint regulation regardless of ATM function.

    Science.gov (United States)

    Xue, Lian; Furusawa, Yoshiya; Okayasu, Ryuichi; Miura, Masahiko; Cui, Xing; Liu, Cuihua; Hirayama, Ryoichi; Matsumoto, Yoshitaka; Yajima, Hirohiko; Yu, Dong

    2015-01-01

    DNA double strand break (DSB) repair pathway choice following ionizing radiation (IR) is currently an appealing research topic, which is still largely unclear. Our recent paper indicated that the complexity of DSBs is a critical factor that enhances DNA end resection. It has been well accepted that the RPA-coated single strand DNA produced by resection is a signaling structure for ATR activation. Therefore, taking advantage of high linear energy transfer (LET) radiation to effectively produce complex DSBs, we investigated how the complexity of DSB influences the function of ATR pathway on the G2/M checkpoint regulation. Human skin fibroblast cells with or without ATM were irradiated with X rays or heavy ion particles, and dual-parameter flow cytometry was used to quantitatively assess the mitotic entry at early period post radiation by detecting the cells positive for phosphor histone H3. In ATM-deficient cells, ATR pathway played a pivotal role and functioned in a dose- and LET-dependent way to regulate the early G2/M arrest even as low as 0.2Gy for heavy ion radiation, which indicated that ATR pathway could be rapidly activated and functioned in an ATM-independent, but DSB complexity-dependent manner following exposure to IR. Furthermore, ATR pathway also functioned more efficiently in ATM-proficient cells to block G2 to M transition at early period of particle radiation exposure. Accordingly, in contrast to ATM inhibitor, ATR inhibitor had a more effective radiosensitizing effect on survival fraction following heavy ion beams as compared with X ray radiation. Taken together, our results reveal that the complexity of DSBs is a crucial factor for the activation of ATR pathway for G2/M checkpoint regulation, and ATM-dependent end resection is not essential for the activation. Copyright © 2014 Elsevier B.V. All rights reserved.

  8. World Congress on Engineering 2014

    CERN Document Server

    Ao, Sio-Iong; Gelman, Len

    2015-01-01

    This volume contains fifty-one revised and extended research articles written by prominent researchers participating in the international conference on Advances in Engineering Technologies and Physical Science (London, UK, 2-4 July, 2014), under the World Congress on Engineering 2014 (WCE 2014). Topics covered include mechanical engineering, bioengineering, internet engineering, wireless networks, image engineering, manufacturing engineering, and industrial applications. The book offers an overview of the tremendous advances made recently in engineering technologies and the physical sciences and their applications, and also serves as an excellent reference for researchers and graduate students working in these fields.

  9. Information and Communication Technologies Innovations conference

    CERN Document Server

    Kocarev, Ljupco

    2012-01-01

    Information and Communication Technologies has enlarged its horizon and it is practiced under multidisciplinary contexts that introduce new challenges to theoretical and technical approaches. The most critical benefit of introducing new ICT technologies in our real world living are the new ways of working that the online world makes possible. Complexity, uncertainty and scaling issues of real world problems as well as natural phenomena in ecology, medicine and biology demanding ICT assistance create challenging application domains for artificial intelligence, decision support and intelligence systems, wireless sensor networks, pervasive and ubiquitous computing, multimedia information systems, data management systems, internet and web applications and services, computer networks, security and cryptography, distributed systems, GRID and cloud computing. This book offers a collection of papers presented at the Third International Conference on ICT Innovations held in September 2011, in Skopje, Macedonia. The co...

  10. International conference, ICPRAM 2012

    CERN Document Server

    Sánchez, J; Fred, Ana; Pattern recognition : applications and methods : revised selected papers

    2013-01-01

    This edited book includes extended and revised versions of a set of selected papers from the First International Conference on Pattern Recognition (ICPRAM 2012), held in Vilamoura, Algarve, Portugal, from 6 to 8 February, 2012, sponsored by the Institute for Systems and Technologies of Information Control and Communication (INSTICC) and held in cooperation with the Association for the Advancement of Artificial Intelligence (AAAI) and Pattern Analysis, Statistical Modelling and Computational Learning (PASCAL2). The conference brought together researchers, engineers and practitioners interested on the areas of Pattern Recognition, both from theoretical and application perspectives.

  11. PHYSICS FOR HEALTH: CONFERENCE

    CERN Multimedia

    2016-01-01

    ICTR-PHE 2016 - International Conference on Translational Research in Radio-Oncology and Physics for Health -, co organized by CERN, aims at developing new strategies to better diagnose and treat cancer, by uniting biology and physics with clinics. Through the various sessions and symposia, the scientific programme offers the delegates the opportunity to discuss, in a friendly atmosphere, the latest progress in physics breakthroughs for health applications. The third edition of this conference took place at CICG (Centre International de Conférence Genève) from 15 to 19 Feb 2016.

  12. Typical worlds

    Science.gov (United States)

    Barrett, Jeffrey A.

    2017-05-01

    Hugh Everett III presented pure wave mechanics, sometimes referred to as the many-worlds interpretation, as a solution to the quantum measurement problem. While pure wave mechanics is an objectively deterministic physical theory with no probabilities, Everett sought to show how the theory might be understood as making the standard quantum statistical predictions as appearances to observers who were themselves described by the theory. We will consider his argument and how it depends on a particular notion of branch typicality. We will also consider responses to Everett and the relationship between typicality and probability. The suggestion will be that pure wave mechanics requires a number of significant auxiliary assumptions in order to make anything like the standard quantum predictions.

  13. Shell worlds

    Science.gov (United States)

    Roy, Kenneth I.; Kennedy, Robert G., III; Fields, David E.

    2013-02-01

    The traditional concept of terraforming assumes ready availability of candidate planets with acceptable qualities: orbiting a star in its "Goldilocks zone", liquid water, enough mass, years longer than days, magnetic field, etc. But even stipulating affordable interstellar travel, we still might never find a good candidate elsewhere. Whatever we found likely would require centuries of heavy terraforming, just as Mars or Venus would here. Our increasing appreciation of the ubiquity of life suggests that any terra nova would already possess it. We would then face the dilemma of introducing alien life forms (us, our microbes) into another living world. Instead, we propose a novel method to create habitable environments for humanity by enclosing airless, sterile, otherwise useless planets, moons, and even large asteroids within engineered shells, which avoids the conundrum. These shells are subject to two opposing internal stresses: compression due to the primary's gravity, and tension from atmospheric pressure contained inside. By careful design, these two cancel each other resulting in zero net shell stress. Beneath the shell an Earth-like environment could be created similar in almost all respects to that of Home, except for gravity, regardless of the distance to the sun or other star. Englobing a small planet, moon, or even a dwarf planet like Ceres, would require astronomical amounts of material (quadrillions of tons) and energy, plus a great deal of time. It would be a quantum leap in difficulty over building Dyson Dots or industrializing our solar system, perhaps comparable to a mission across interstellar space with a living crew within their lifetime. But when accomplished, these constructs would be complete (albeit small) worlds, not merely large habitats. They could be stable across historic timescales, possibly geologic. Each would contain a full, self-sustaining ecology, which might evolve in curious directions over time. This has interesting implications

  14. 78 FR 27963 - Reliability Technical Conference; Notice of Technical Conference

    Science.gov (United States)

    2013-05-13

    ... Energy Regulatory Commission Reliability Technical Conference; Notice of Technical Conference Take notice that the Federal Energy Regulatory Commission will hold a Technical Conference on Tuesday, July 9, 2013... to the webcast. The Capitol Connection provides technical support for webcasts and offers the option...

  15. Education for Sustainable Development at the United Nations Conference on Sustainable Development (Rio+20)

    Science.gov (United States)

    Journal of Education for Sustainable Development, 2012

    2012-01-01

    The United Nations Conference on Sustainable Development (Rio+20) was held in Rio de Janeiro, Brazil, 20-22 June 2012, marking the twentieth anniversary of the United Nations Conference on Sustainable Development in Rio de Janeiro in 1992 and the tenth anniversary of the 2002 World Summit on Sustainable Development in Johannesburg. With more than…

  16. 11th Portuguese Conference on Automatic Control

    CERN Document Server

    Matos, Aníbal; Veiga, Germano

    2015-01-01

    During the last 20 years the Portuguese association of automatic control, Associação Portuguesa de Controlo Automático, with the sponsorship of IFAC have established the CONTROLO conference as a reference international forum where an effective exchange of knowledge and experience amongst researchers active in various theoretical and applied areas of systems and control can take place, always including considerable space for promoting new technical applications and developments, real-world challenges and success stories. In this 11th edition the CONTROLO conference evolved by introducing two strategic partnerships with Spanish and Brazilian associations in automatic control, Comité Español de Automática and Sociedade Brasileira de Automatica, respectively.

  17. Korean Conference on Several Complex Variables

    CERN Document Server

    Byun, Jisoo; Gaussier, Hervé; Hirachi, Kengo; Kim, Kang-Tae; Shcherbina, Nikolay

    2015-01-01

    This volume includes 28 chapters by authors who are leading researchers of the world describing many of the up-to-date aspects in the field of several complex variables (SCV). These contributions are based upon their presentations at the 10th Korean Conference on Several Complex Variables (KSCV10), held as a satellite conference to the International Congress of Mathematicians (ICM) 2014 in Seoul, Korea. SCV has been the term for multidimensional complex analysis, one of the central research areas in mathematics. Studies over time have revealed a variety of rich, intriguing, new knowledge in complex analysis and geometry of analytic spaces and holomorphic functions which were "hidden" in the case of complex dimension one. These new theories have significant intersections with algebraic geometry, differential geometry, partial differential equations, dynamics, functional analysis and operator theory, and sheaves and cohomology, as well as the traditional analysis of holomorphic functions in all dimensions. This...

  18. 2nd International Conference on Pattern Recognition

    CERN Document Server

    Marsico, Maria

    2015-01-01

    This book contains the extended and revised versions of a set of selected papers from the 2nd International Conference on Pattern Recognition (ICPRAM 2013), held in Barcelona, Spain, from 15 to 18 February, 2013. ICPRAM was organized by the Institute for Systems and Technologies of Information, Control and Communication (INSTICC) and was held in cooperation with the Association for the Advancement of Artificial Intelligence (AAAI). The hallmark of this conference was to encourage theory and practice to meet in a single venue. The focus of the book is on contributions describing applications of Pattern Recognition techniques to real-world problems, interdisciplinary research, experimental and/or theoretical studies yielding new insights that advance Pattern Recognition methods.

  19. 6th International Conference on ICT Innovations

    CERN Document Server

    Gjorgjevikj, Dejan

    2015-01-01

    Data is a common ground, a starting point for each ICT system. Data needs processing, use of different technologies and state-of-the-art methods in order to obtain new knowledge, to develop new useful applications that not only ease, but also increase the quality of life. These applications use the exploration of Big Data, High throughput data, Data Warehouse, Data Mining, Bioinformatics, Robotics, with data coming from social media, sensors, scientific applications, surveillance, video and image archives, internet texts and documents, internet search indexing, medical records, business transactions, web logs, etc. Information and communication technologies have become the asset in everyday life enabling increased level of communication, processing and information exchange. This book offers a collection of selected papers presented at the Sixth International Conference on ICT Innovations held in September 2014, in Ohrid, Macedonia, with main topic World of data. The conference gathered academics, professional...

  20. 13th International Conference Intelligent Autonomous Systems

    CERN Document Server

    Michael, Nathan; Berns, Karsten; Yamaguchi, Hiroaki

    2016-01-01

    This book describes the latest research accomplishments, innovations, and visions in the field of robotics as presented at the 13th International Conference on Intelligent Autonomous Systems (IAS), held in Padua in July 2014, by leading researchers, engineers, and practitioners from across the world. The contents amply confirm that robots, machines, and systems are rapidly achieving intelligence and autonomy, mastering more and more capabilities such as mobility and manipulation, sensing and perception, reasoning, and decision making. A wide range of research results and applications are covered, and particular attention is paid to the emerging role of autonomous robots and intelligent systems in industrial production, which reflects their maturity and robustness. The contributions have been selected through a rigorous peer-review process and contain many exciting and visionary ideas that will further galvanize the research community, spurring novel research directions. The series of biennial IAS conferences ...

  1. The application of ATR-FTIR spectroscopy and multivariate data analysis to study drug crystallisation in the stratum corneum.

    Science.gov (United States)

    Goh, Choon Fu; Craig, Duncan Q M; Hadgraft, Jonathan; Lane, Majella E

    2017-02-01

    Drug permeation through the intercellular lipids, which pack around and between corneocytes, may be enhanced by increasing the thermodynamic activity of the active in a formulation. However, this may also result in unwanted drug crystallisation on and in the skin. In this work, we explore the combination of ATR-FTIR spectroscopy and multivariate data analysis to study drug crystallisation in the skin. Ex vivo permeation studies of saturated solutions of diclofenac sodium (DF Na) in two vehicles, propylene glycol (PG) and dimethyl sulphoxide (DMSO), were carried out in porcine ear skin. Tape stripping and ATR-FTIR spectroscopy were conducted simultaneously to collect spectral data as a function of skin depth. Multivariate data analysis was applied to visualise and categorise the spectral data in the region of interest (1700-1500cm-1) containing the carboxylate (COO-) asymmetric stretching vibrations of DF Na. Spectral data showed the redshifts of the COO- asymmetric stretching vibrations for DF Na in the solution compared with solid drug. Similar shifts were evident following application of saturated solutions of DF Na to porcine skin samples. Multivariate data analysis categorised the spectral data based on the spectral differences and drug crystallisation was found to be confined to the upper layers of the skin. This proof-of-concept study highlights the utility of ATR-FTIR spectroscopy in combination with multivariate data analysis as a simple and rapid approach in the investigation of drug deposition in the skin. The approach described here will be extended to the study of other actives for topical application to the skin. Copyright © 2016 Elsevier B.V. All rights reserved.

  2. Mutation analysis and characterization of ATR sequence variants in breast cancer cases from high-risk French Canadian breast/ovarian cancer families

    Directory of Open Access Journals (Sweden)

    Pichette Roxane

    2006-09-01

    Full Text Available Abstract Background Ataxia telangiectasia-mutated and Rad3-related (ATR is a member of the PIK-related family which plays, along with ATM, a central role in cell-cycle regulation. ATR has been shown to phosphorylate several tumor suppressors like BRCA1, CHEK1 and TP53. ATR appears as a good candidate breast cancer susceptibility gene and the current study was designed to screen for ATR germline mutations potentially involved in breast cancer predisposition. Methods ATR direct sequencing was performed using a fluorescent method while widely available programs were used for linkage disequilibrium (LD, haplotype analyses, and tagging SNP (tSNP identification. Expression analyses were carried out using real-time PCR. Results The complete sequence of all exons and flanking intronic sequences were analyzed in DNA samples from 54 individuals affected with breast cancer from non-BRCA1/2 high-risk French Canadian breast/ovarian families. Although no germline mutation has been identified in the coding region, we identified 41 sequence variants, including 16 coding variants, 3 of which are not reported in public databases. SNP haplotypes were established and tSNPs were identified in 73 healthy unrelated French Canadians, providing a valuable tool for further association studies involving the ATR gene, using large cohorts. Our analyses led to the identification of two novel alternative splice transcripts. In contrast to the transcript generated by an alternative splicing site in the intron 41, the one resulting from a deletion of 121 nucleotides in exon 33 is widely expressed, at significant but relatively low levels, in both normal and tumoral cells including normal breast and ovarian tissue. Conclusion Although no deleterious mutations were identified in the ATR gene, the current study provides an haplotype analysis of the ATR gene polymorphisms, which allowed the identification of a set of SNPs that could be used as tSNPs for large-scale association

  3. Validation of a χ2 model of HRR target RCS variability and verification of the resulting ATR performance model

    Science.gov (United States)

    Holt, Craig R.; Attili, Joseph B.; Schmidt, Steven L.

    2001-10-01

    A (chi) 2 model for radar cross section (RCS) variability of High Range Resolution (HRR) measurements is validated using compact range data from the U.S. Army National Ground Intelligence Center (NGIC). It is shown that targets can be represented by a mean template and by a variance template, or in this case, an effective number of degrees-of-freedom for the (chi) 2-distribution. The analysis also includes comparison of the measured tails of the RCS distribution to that predicated by the (chi) 2-distribution. The likelihood classifier is obtained, and a Monte Carlo performance model is developed to validate the statistical model at the level of ATR performance.

  4. Analysis of European Honeybee (Apis Mellifera Wings Using ATR-FTIR and Raman Spectroscopy: A Pilot Study

    Directory of Open Access Journals (Sweden)

    Machovič V.

    2017-03-01

    Full Text Available The infrared (ATR-FTIR and Raman spectroscopy was used for the structural characterization of honeybee wings. Protein, chitin, and lipid characteristic spectral features were detected using both methods. The protein secondary structure was predominantly composed of the β-sheet molecular conformation with β-turns or coil contributions. The vibration modes of the side-chain aromatic amino acid residues (tyrosine, phenylalanine, tryptophan occurred in the wing spectra. The results of discriminant analysis showed that the infrared spectroscopy of the wing in combination with a multivariate analysis seemed promising for a resolution of the chemical structure of the wings based on lipid, proteins, and chitin content.

  5. Differentiation and identification of fungi by ATR-FTIR method in a leather collection relating back to Seljuk period

    Directory of Open Access Journals (Sweden)

    Mohsen Mohammadi Achachluei

    2013-01-01

    Full Text Available Introduction: Biodegradation is one of the main degrading factors of leather artifacts. Determination of fungi and other microorganisms has vital importance for conservation of valuable objects made from organic materials. Usual classic techniques for identification of pathogens and fungi have some difficulties, but FTIR spectroscopy has been introduced as useful technique for characterization and determination of microorganisms. Materials and methods: In this study, historic leathers were related to the Seljuk period. The leathers were sampled in laboratory and fungi were cultivated in SDA medium. Genuses of fungi were identified according to macroscopic, microscopic and morphologic characteristics. Microorganisms were analyzed by ATR-FTIR spectrometer and differences of spectral properties were assessed. Spectral properties were assessed according to form and absorption region of peaks. Cluster analysis was used for evaluation of different regions and areas on the measured spectra.Results: Results showed the presence of Penicillium sp. (9 samples, 33.3%, Aspergillus sp. (5 samples, 18.5%, Cladosporium sp. (4 samples, 14.8%, Rhizoctonia sp. (2 samples, 7.4%, Trichophyton sp. (1 sample, 3.7% and also one sample of yeast (3.7%. Two species of fungi remained unidentified (7.4% and there was not any growth in 3 samples (11.1%. Spectral properties indicated to structural differences between microorganisms (fungi, yeast, bacteria. It showed characteristics of fungi genus and species in some cases.Discussion and conclusion: Active fungi induce decomposition, hydrolysis and decay of leather and its vegetable tannins. The decay leads to aesthetic change and health problems. Therefore, it is necessary to remove of fungi and appropriate treatment of leather artifacts. Application of ATR-FTIR spectroscopy had good results for identification of fungi, yeast and bacteria. Assessments showed the potential of ATR-FTIR spectroscopy for easy and rapid

  6. Microstructural examination of V-(3-6%)Cr-(3-5%)Ti irradiated in the ATR-A1 experiment

    Energy Technology Data Exchange (ETDEWEB)

    Gelles, D.S. [Pacific Northwest National Lab., Richland, WA (United States)

    1998-09-01

    Microstructural examination results are reported for four heats of V-(3-6%)Cr-(3-5%)Ti irradiated in the ATR-A1 experiment to {approximately}4 dpa at {approximately}200 and 300 C to provide an understanding of the microstructural evolution that may be associated with degradation of mechanical properties. Fine precipitates were observed in high density intermixed with small defect clusters for all conditions examined following the irradiation. The irradiation-induced precipitation does not appear to be affected by preirradiation heat treatment or composition.

  7. Metabolic Engineering X Conference

    Energy Technology Data Exchange (ETDEWEB)

    Flach, Evan [American Institute of Chemical Engineers

    2015-05-07

    The International Metabolic Engineering Society (IMES) and the Society for Biological Engineering (SBE), both technological communities of the American Institute of Chemical Engineers (AIChE), hosted the Metabolic Engineering X Conference (ME-X) on June 15-19, 2014 at the Westin Bayshore in Vancouver, British Columbia. It attracted 395 metabolic engineers from academia, industry and government from around the globe.

  8. 2008 Combat Vehicles Conference

    Science.gov (United States)

    2008-10-22

    General Michael M. Brogan Combat Vehicles Conference Marine Corps Systems Command 21 October 2008 2 MCSC •LAV •AAV •Tank •HMMWV/ ECV •MRAP PEO LS...34,226 Total 56,649 1985 IOC 1996 M1114 armored HMMWV Limited Production 2006 M1100 series begins fielding scalable armor 2009-10 ECV II

  9. International Nuclear Physics Conference

    CERN Document Server

    2016-01-01

    We are pleased to announce that the 26th International Nuclear Physics Conference (INPC2016) will take place in Adelaide (Australia) from September 11-16, 2016. The 25th INPC was held in Firenze in 2013 and the 24th INPC in Vancouver, Canada, in 2010. The Conference is organized by the Centre for the Subatomic Structure of Matter at the University of Adelaide, together with the Australian National University and ANSTO. It is also sponsored by the International Union of Pure and Applied Physics (IUPAP) and by a number of organisations, including AUSHEP, BNL, CoEPP, GSI and JLab. INPC 2016 will be held in the heart of Adelaide at the Convention Centre on the banks of the River Torrens. It will consist of 5 days of conference presentations, with plenary sessions in the mornings, up to ten parallel sessions in the afternoons, poster sessions and a public lecture. The Conference will officially start in the evening of Sunday 11th September with Registration and a Reception and will end late on the afternoon of ...

  10. 2002 NASPSA Conference Abstracts.

    Science.gov (United States)

    Journal of Sport & Exercise Psychology, 2002

    2002-01-01

    Contains abstracts from the 2002 conference of the North American Society for the Psychology of Sport and Physical Activity. The publication is divided into three sections: the preconference workshop, "Effective Teaching Methods in the Classroom;" symposia (motor development, motor learning and control, and sport psychology); and free…

  11. Leader Training Conference Report.

    Science.gov (United States)

    Michigan-Ohio Regional Educational Lab., Inc., Detroit.

    The purpose of this conference was to prepare key people in the field of education to function as inservice education leaders in their respective settings. It called for participants to learn what the MOREL inservice education program is and what it hopes to accomplish, to identify the role and functions of the inservice education leader, and to…

  12. Conferences and Events

    International Development Research Centre (IDRC) Digital Library (Canada)

    André Lavoie

    2016-01-18

    Jan 18, 2016 ... Evening meal events for Governors, held in connection with Board meetings, must not cost more per person than 2.625 times the applicable meal allowance. The Chair of the Board must authorize any exception to the provision of this paragraph. Overnight stays related to events (other than conferences and ...

  13. Microbicides 2006 conference

    Directory of Open Access Journals (Sweden)

    McGowan Ian

    2006-10-01

    Full Text Available Abstract Current HIV/AIDS statistics show that women account for almost 60% of HIV infections in Sub-Saharan Africa. HIV prevention tools such as male and female condoms, abstinence and monogamy are not always feasible options for women due to various socio-economic and cultural factors. Microbicides are products designed to be inserted in the vagina or rectum prior to sex to prevent HIV acquisition. The biannual Microbicides conference took place in Cape Town, South Africa from 23–26 April 2006. The conference was held for the first time on the African continent, the region worst affected by the HIV/AIDS pandemic. The conference brought together a record number of 1,300 scientists, researchers, policy makers, healthcare workers, communities and advocates. The conference provided an opportunity for an update on microbicide research and development as well as discussions around key issues such as ethics, acceptability, access and community involvement. This report discusses the current status of microbicide research and development, encompassing basic and clinical science, social and behavioural science, and community mobilisation and advocacy activities.

  14. International Asia Conference on Industrial Engineering and Management Innovation

    CERN Document Server

    Shen, Jiang; Dou, Runliang

    2013-01-01

    The International Conference on Industrial Engineering and Engineering Management is sponsored by the Chinese Industrial Engineering Institution, CMES, which is the only national-level academic society for Industrial Engineering. The conference is held annually as the major event in this arena. Being the largest and the most authoritative international academic conference held in China, it provides an academic platform for experts and entrepreneurs in the areas of international industrial engineering and management to exchange their research findings. Many experts in various fields from China and around the world gather together at the conference to review, exchange, summarize and promote their achievements in the fields of industrial engineering and engineering management. For example, some experts pay special attention to the current state of the application of related techniques in China as well as their future prospects, such as green product design, quality control and management, supply chain and logist...

  15. International Sanitary Conferences from the Ottoman perspective (1851–1938

    Directory of Open Access Journals (Sweden)

    Nermin Ersoy

    2011-01-01

    Full Text Available The search for international measures to prevent and control epidemics of cholera, the plague, yellow fever, malaria and typhus which ravaged the world throughout the 19th century, led to a series of International Sanitary Conferences and Conventions under the leadership of European states. Between 1851 and 1938 fourteen conferences - Paris (1851, Paris (1859, Istanbul (1866, Vienna (1874, Washington D.C. (1881, Rome (1885, Venice (1892, Dresden (1893, Paris (1894, Venice (1897, Paris (1903, (1911, (1926 and (1938 - and eight conventions - 1892, 1893, 1894, 1897, 1903, 1912, 1926, 1938 were held. Both conferences and conventions shaped social life, health policies, politics, laws, and transportation, economic, commercial rules of the European, Asian and also American countries. In this study we reviewed the reasons, process and the results of each international sanitary conference from the Ottoman social and health perspective.

  16. International conference on string theory

    CERN Document Server

    2016-01-01

    The Strings conference is an annual event that brings the entire string theory community together. Since the 1980s, it has grown to be the largest and most important conference in the field. The aim is to review recent developments in string theory and to stimulate scientific exchanges among the participants. This is the second Strings conference organised in Beijing, after Strings 2006. Following the tradition, besides scientific talks, the conference will also include some public lectures open to a general audience.

  17. Tip-enhanced near-field optical microscope with side-on and ATR-mode sample excitation for super-resolution Raman imaging of surfaces

    Energy Technology Data Exchange (ETDEWEB)

    Heilman, A. L.; Gordon, M. J. [Department of Chemical Engineering, University of California Santa Barbara, Santa Barbara, California 93106-5080 (United States)

    2016-06-14

    A tip-enhanced near-field optical microscope with side-on and attenuated total reflectance (ATR) excitation and collection is described and used to demonstrate sub-diffraction-limited (super-resolution) optical and chemical characterization of surfaces. ATR illumination is combined with an Au optical antenna tip to show that (i) the tip can quantitatively transduce the optical near-field (evanescent waves) above the surface by scattering photons into the far-field, (ii) the ATR geometry enables excitation and characterization of surface plasmon polaritons (SPPs), whose associated optical fields are shown to enhance Raman scattering from a thin layer of copper phthalocyanine (CuPc), and (iii) SPPs can be used to plasmonically excite the tip for super-resolution chemical imaging of patterned CuPc via tip-enhanced Raman spectroscopy (TERS). ATR-illumination TERS is also quantitatively compared with the more conventional side-on illumination scheme. In both cases, spatial resolution was better than 40 nm and tip on/tip off Raman enhancement factors were >6500. Furthermore, ATR illumination was shown to provide similar Raman signal levels at lower “effective” pump powers due to additional optical energy delivered by SPPs to the active region in the tip-surface gap.

  18. ON-LINE MONITORING OF I&C TRANSMITTERS AND SENSORS FOR CALIBRATION VERIFICATION AND RESPONSE TIME TESTING WAS SUCCESSFULLY IMPLEMENTED AT ATR

    Energy Technology Data Exchange (ETDEWEB)

    Erickson, Phillip A.; O' Hagan, Ryan; Shumaker, Brent; Hashemian, H. M.

    2017-03-01

    The Advanced Test Reactor (ATR) has always had a comprehensive procedure to verify the performance of its critical transmitters and sensors, including RTDs, and pressure, level, and flow transmitters. These transmitters and sensors have been periodically tested for response time and calibration verification to ensure accuracy. With implementation of online monitoring techniques at ATR, the calibration verification and response time testing of these transmitters and sensors are verified remotely, automatically, hands off, include more portions of the system, and can be performed at almost any time during process operations. The work was done under a DOE funded SBIR project carried out by AMS. As a result, ATR is now able to save the manpower that has been spent over the years on manual calibration verification and response time testing of its temperature and pressure sensors and refocus those resources towards more equipment reliability needs. More importantly, implementation of OLM will help enhance the overall availability, safety, and efficiency. Together with equipment reliability programs of ATR, the integration of OLM will also help with I&C aging management goals of the Department of Energy and long-time operation of ATR.

  19. Editorial: Special Issue (SI): International Conference on Science Education (ICSE)

    Science.gov (United States)

    Liu, Xiufeng; Zhang, BaoHui

    2014-04-01

    In the context of science education globalization, the International Conference on Science Education was held in Nanjing, China, in October 2012. The purpose of this conference was to provide a forum for science education researchers from China and from the rest of the world to exchange research ideas and best practices in science education. A call for papers for a special issue of the Journal of Science Education and Technology was made to all conference participants, and a set of six articles was resulted from a standard peer review process. This set of six articles provides a snapshot of research in China and in some other countries, and represents a dialogue between Chinese science education researchers and science education researchers from other countries. We call for more exchange and collaboration in science education between China and the rest of the world.

  20. Indico CONFERENCE: Define the Programme

    CERN Multimedia

    CERN. Geneva; Ferreira, Pedro

    2017-01-01

    In this tutorial you are going to learn how to define the programme of a conference in Indico. The program of your conference is divided in different “tracks”. Tracks represent the subject matter of the conference, such as “Online Computing”, “Offline Computing”, and so on.

  1. Sobre el iuspositivismo que hemos de dejar atrás. Una crítica iusnaturalista a "Dejemos atrás el positivismo jurídico" de Atienza y de Ruiz Manero

    Directory of Open Access Journals (Sweden)

    JOSÉ CHÁVEZ-FERNÁNDEZ

    2011-01-01

    Full Text Available A través de la confrontación de las tesis más relevantes que Atienza y Ruiz Manero proponen en su artículo "Dejemos atrás el positivismo jurídico", el autor pretende mostrar-a partir de la respuesta a las preguntas "¿qué iuspositivismo hemos de dejar atrás?", "¿por qué?" y "¿cómo?"- que existen en el iuspositivismo debilidades explicativas graves respecto de la realidad jurídica, y que estas están vinculadas tanto al escepticismo ético como a la negación de la existencia de un Derecho natural en sentido propio, es decir, de raigambre antropológico-metafísica. Por otro lado, se tratará de evidenciar que dichas debilidades explicativas le son comunes también a los intentos pragmático-constructivistas de superación del iuspositivismo por lo que, en última instancia, ninguno de dichos esquemas conceptuales puede dar cuenta cabal de una realidad como los derechos humanos que se presentan como deudas ético-jurídicas inexcusables fundamentadas en la dignidad ontológica de todos los seres humanos.

  2. Global Impressions: Inside UNESCO's First Worldwide Arts Education Conference

    Science.gov (United States)

    Booth, Eric

    2006-01-01

    The many worlds of arts education began to grow into one worldwide community in March 2006. Twelve hundred arts education leaders, in delegations from 97 countries, attended the United Nation's Education, Scientific and Cultural Organization's (UNESCO's) first-ever worldwide arts education conference, held for four days in Lisbon, Portugal. The…

  3. conference report prevention of mother-to-child transmission

    African Journals Online (AJOL)

    2004-08-02

    Aug 2, 2004 ... archive of all abstracts presented at the Conference (eJIAS abstract finder) is available at http://www.aids2004.org/. REFERENCES. 1. World Health Organisation. Antiretroviral Drugs and the Prevention of Mother-to- child Transmission of HIV Infection in Resource-limited Settings. Geneva: WHO,. 2004. 2.

  4. CERN announces major conference on the information society

    CERN Multimedia

    2003-01-01

    "A side event to the World Summit on the Information Society (Geneva, December 2003) will explore the past and future contributions of science to the information society. Hosted by CERN , the Role of Science in the Information Society (RSIS) conference will bring together scientists and representatives of funding agencies and governments worldwide" (1 page).

  5. 7th european metallurgical conference EMC 2013

    Directory of Open Access Journals (Sweden)

    Srećko R. Stopić

    2014-02-01

    /Process Modelling, Waste heat recovery by ORC Power Generation Vol. 3: General Hydrometallurgy, General Pyrometallurgy, Vessel Integrity, Process Gas Treatment; Recycling The plenary lectures will be published in the scientific journal “World of Metallurgy – ERZMETALL”, published by GDMB. The next 8th European Metallurgical Conference will be held between June 14 and June 17, 2015 in Duesseldorf. 

  6. WorldWideScience.org: Bringing Light to Grey

    OpenAIRE

    Hitson, Brian A. (OSTI-DOE); Johnson, Lorrie A. (OSTI-DOE); GreyNet, Grey Literature Network Service

    2008-01-01

    WorldWideScience.org and its governance structure, the WorldWideScience Alliance, are putting a brighter spotlight on grey literature. Through this new tool, grey literature is getting broader exposure to audiences all over the world. Improved access to and sharing of research information is the key to accelerating progress and breakthroughs in any field, especially science. Includes: Conference preprint, Powerpoint presentation, Abstract and Biographical notes, Pratt student commentary ...

  7. In-situ monitoring of blood glucose level for dialysis machine by AAA-battery-size ATR Fourier spectroscopy

    Science.gov (United States)

    Hosono, Satsuki; Sato, Shun; Ishida, Akane; Suzuki, Yo; Inohara, Daichi; Nogo, Kosuke; Abeygunawardhana, Pradeep K.; Suzuki, Satoru; Nishiyama, Akira; Wada, Kenji; Ishimaru, Ichiro

    2015-07-01

    For blood glucose level measurement of dialysis machines, we proposed AAA-battery-size ATR (Attenuated total reflection) Fourier spectroscopy in middle infrared light region. The proposed one-shot Fourier spectroscopic imaging is a near-common path and spatial phase-shift interferometer with high time resolution. Because numerous number of spectral data that is 60 (= camera frame rare e.g. 60[Hz]) multiplied by pixel number could be obtained in 1[sec.], statistical-averaging improvement realize high-accurate spectral measurement. We evaluated the quantitative accuracy of our proposed method for measuring glucose concentration in near-infrared light region with liquid cells. We confirmed that absorbance at 1600[nm] had high correlations with glucose concentrations (correlation coefficient: 0.92). But to measure whole-blood, complex light phenomenon caused from red blood cells, that is scattering and multiple reflection or so, deteriorate spectral data. Thus, we also proposed the ultrasound-assisted spectroscopic imaging that traps particles at standing-wave node. Thus, if ATR prism is oscillated mechanically, anti-node area is generated around evanescent light field on prism surface. By elimination complex light phenomenon of red blood cells, glucose concentration in whole-blood will be quantify with high accuracy. In this report, we successfully trapped red blood cells in normal saline solution with ultrasonic standing wave (frequency: 2[MHz]).

  8. A new integrated TLC/MU-ATR/SERS advanced approach for the identification of trace amounts of dyes in mixtures.

    Science.gov (United States)

    Sciutto, Giorgia; Prati, Silvia; Bonacini, Irene; Litti, Lucio; Meneghetti, Moreno; Mazzeo, Rocco

    2017-10-23

    The present research is focused on the setting up of an advanced analytical system for the detection of synthetic dyes. The system is based on the combination of an innovative thin layer chromatography (TLC) plate coupled with enhanced infrared (MU-ATR, metal underlayer attenuated total reflection) and Surface Enhanced Raman (SERS) spectroscopy. In particular, a TLC plate made of silver iodide (AgI) applied onto a gold coated glass slide (AgI@Au) is proposed as an efficient stationary phase for the separation of dyes mixtures. The separated dyes are then identified by means of both enhanced FTIR and SERS, performed directly on the same eluted spots. The use of a mid-IR transparent inorganic salt as stationary phase coupled with the underneath gold layer avoids spectral interferences, enhancing the signal obtained from ATR analyses. At the same time, SERS spectra can be recorded as the TLC plate may act as a SERS active substrate due to the photoreduction of AgI to metallic Ag caused by the exposure to the laser during the Raman analysis. Different mixtures of synthetic dyes of known composition, widely used in dyeing processes, have been tested and the method resulted to be effective in identifying trace amounts in the order of tens nanograms. Moreover, the method has been further evaluated on a real case study represented by dyes extracted from dyed wool. Copyright © 2017 Elsevier B.V. All rights reserved.

  9. Splicing mutation in the ATR-X gene can lead to a dysmorphic mental retardation phenotype without {alpha}-thalassemia

    Energy Technology Data Exchange (ETDEWEB)

    Villard, L.; Lossi, A.M.; Fontes, M. [and others

    1996-03-01

    We have previously reported the isolation of a gene from Xq13 that codes for a putative regulator of transcription (XNP) and has now been shown to be the gene involved in the X-linked {alpha}-thalassemia with mental retardation (ATR-X) syndrome. The widespread expression and numerous domains present in the putative protein suggest that this gene could be involved in other phenotypes. The predominant expression of the gene in the developing brain, as well as its association with neuron differentiation, indicates that mutations of this gene might result in a mental retardation (MR) phenotype. In this paper we present a family with a splice junction mutation in XNP that results in the skipping of an exon and in the introduction of a stop codon in the middle of the XNP-coding sequence. Only the abnormal transcript is expressed in two first cousins presenting the classic ATR-X phenotype (with {alpha}-thalassemia and HbH inclusions). In a distant cousin presenting a similar dysmorphic MR phenotype but not having thalassemia, {approximately}30% of the XNP transcripts are normal. These data demonstrate that the mode of action of the XNP gene product on globin expression is distinct from its mode of action in brain development and facial morphogenesis and suggest that other dysmorphic mental retardation phenotypes, such as Juberg-Marsidi or some sporadic cases of Coffin-Lowry, could be due to mutations in XNP. 20 refs., 5 figs., 2 tabs.

  10. Simultaneous ATR-FTIR Based Determination of Malaria Parasitemia, Glucose and Urea in Whole Blood Dried onto a Glass Slide.

    Science.gov (United States)

    Roy, Supti; Perez-Guaita, David; Andrew, Dean W; Richards, Jack S; McNaughton, Don; Heraud, Philip; Wood, Bayden R

    2017-05-16

    New diagnostic tools that can detect malaria parasites in conjunction with other diagnostic parameters are urgently required. In this study, Attenuated Total Reflection Fourier transform infrared (ATR-FTIR) spectroscopy in combination with Partial Least Square Discriminant Analysis (PLS-DA) and Partial Least Square Regression (PLS-R) have been applied as a point-of-care test for identifying malaria parasites, blood glucose, and urea levels in whole blood samples from thick blood films on glass slides. The specificity for the PLS-DA was found to be 98% for parasitemia levels >0.5%, but a rather low sensitivity of 70% was achieved because of the small number of negative samples in the model. In PLS-R the Root Mean Square Error of Cross Validation (RMSECV) for parasite concentration (0-5%) was 0.58%. Similarly, for glucose (0-400 mg/dL) and urea (0-250 mg/dL) spiked samples, relative RMSECVs were 16% and 17%, respectively. The method reported here is the first example of multianalyte/disease diagnosis using ATR-FTIR spectroscopy, which in this case, enabled the simultaneous quantification of glucose and urea analytes along with malaria parasitemia quantification using one spectrum obtained from a single drop of blood on a glass microscope slide.

  11. ATR FT-IR spectroscopy on Vmh2 hydrophobin self-assembled layers for Teflon membrane bio-functionalization

    Energy Technology Data Exchange (ETDEWEB)

    Portaccio, M., E-mail: marianna.portaccio@unina2.it [Dipartimento di Medicina Sperimentale – Seconda Università di Napoli, Via S.M. di Costantinopoli, 16-80134 Napoli (Italy); Gravagnuolo, A.M., E-mail: alfredomaria.gravagnuolo@unina.it [Dipartimento di Scienze Chimiche, Università “Federico II”, Via Cintia, 21- 80126 Napoli (Italy); Longobardi, S., E-mail: sara.longobardi@unina.it [Dipartimento di Scienze Chimiche, Università “Federico II”, Via Cintia, 21- 80126 Napoli (Italy); Giardina, P., E-mail: paola.giardina@unina.it [Dipartimento di Scienze Chimiche, Università “Federico II”, Via Cintia, 21- 80126 Napoli (Italy); Rea, I., E-mail: ilaria.rea@na.imm.cnr.it [Institute for Microelectronics and Microsystems, CNR, Via P. Castellino, 111-80131 Napoli (Italy); De Stefano, L., E-mail: luca.destefano@na.imm.cnr.it [Institute for Microelectronics and Microsystems, CNR, Via P. Castellino, 111-80131 Napoli (Italy); Cammarota, M., E-mail: marcella.cammarota@unina2.it [Dipartimento di Medicina Sperimentale – Seconda Università di Napoli, Via S.M. di Costantinopoli, 16-80134 Napoli (Italy); Lepore, M., E-mail: maria.lepore@unina2.it [Dipartimento di Medicina Sperimentale – Seconda Università di Napoli, Via S.M. di Costantinopoli, 16-80134 Napoli (Italy)

    2015-10-01

    Graphical abstract: - Highlights: • Hydrophobin self-assembled layers on Teflon in different preparation conditions were investigated. • ATR collection data geometry allowed samples examination without any particular preparation. • Amide content, lipid/amide and carbohydrate/amide ratios of the protein layer were estimated. • Secondary structure of protein was determined for the examined samples. • FT-IR demonstrated to be of extreme relevance in monitoring hydrophobin self-assembled layers preparation. - Abstract: Surface functionalization by layers of hydrophobins, amphiphilic proteins produced by fungi offers a promising and green strategy for fabrication of biomedical and bioanalytical devices. The layering process of the Vmh2 hydrophobin from Pleurotus ostreatus on Teflon membrane has been investigated by Attenuated Total Reflection Fourier Transform Infrared (ATR FT-IR) spectroscopy. In particular, protein layers obtained with hydrophobin purified with two different procedures and in various coating conditions have been examined. The layers have been characterized by quantifying the amide I and amide II band area together with the lipid/amide ratio and carbohydrate/amide ratio. This characterization can be very useful in evaluating the best purification strategy and coating conditions. Moreover the analysis of the secondary structure of the layered protein using the deconvolution procedure of amide I band indicate the prevalent contribution from β-sheet state. The results inferred by infrared spectroscopy have been also confirmed by scanning electron microscopy imaging.

  12. Characterization of Satsuma mandarin (Citrus unshiu Marc.) nectar-to-honey transformation pathway using FTIR-ATR spectroscopy.

    Science.gov (United States)

    Svečnjak, Lidija; Prđun, Saša; Rogina, Josip; Bubalo, Dragan; Jerković, Igor

    2017-10-01

    Samples of Satsuma mandarin (Citrus unshiu Marc.) nectar, honey sac content and honey were analyzed by FTIR-ATR spectroscopy and reference methods. The spectral analysis allowed detection of the major chemical constituents in C. unshiu nectar-to-honey transformation pathway thus providing information on the intensity and location of the compositional changes occurring during this process. The preliminary results showed that in average more than one-third of sugar-related nectar-to-honey conversion takes place directly in the honey sac; the average sugar content (w/w) was 17.93% (nectar), 47.03% (honey sac) and 79.63% (honey). FTIR-ATR results showed great spectral similarity of analyzed honey samples and small degree variations in both sugar and water content in nectar samples. The spectral data revealed distinctive differences in the chemical composition of individual honey sac contents with the most intensive and complex absorption envelope in the spectral region between 1175 and 950cm -1 (glucose, fructose and sucrose absorption bands). Copyright © 2017 Elsevier Ltd. All rights reserved.

  13. Cocaine profiling: Implementation of a predictive model by ATR-FTIR coupled with chemometrics in forensic chemistry.

    Science.gov (United States)

    Materazzi, Stefano; Gregori, Adolfo; Ripani, Luigi; Apriceno, Azzurra; Risoluti, Roberta

    2017-05-01

    In this study, a strategy based on Infrared Spectroscopy with Fourier Transformed and Attenuated Total Reflectance associated with chemometrics (ATR-FTIR) is proposed to identify the chemical "fingerprint" of cocaine samples. To this end, standard mixtures of cocaine and cuttings at differents ratio were investigated in order to develop a multivariate classification model to simultaneously predict the composition of the samples and to obtain a profile of adulteration of cocaine seizures. In addition, the application of a Partial Least Squares (PLS) and Principal Component Regression (PCR) calibration approaches were found to be a useful tool to predict the content of cocaine, caffeine, procaine, lidocaine and phenacetin in drug seizures. The achieved results on real confiscated samples, in cooperation with the Italian Scientific Investigation Department (Carabinieri-RIS) of Rome, allow to consider ATR-FTIR followed to chemometrics as a promising forensic tool in such situations involving profile comparisons and supporting forensic investigations. Copyright © 2017 Elsevier B.V. All rights reserved.

  14. Prediction of peroxide value in omega-3 rich microalgae oil by ATR-FTIR spectroscopy combined with chemometrics.

    Science.gov (United States)

    Cebi, Nur; Yilmaz, Mustafa Tahsin; Sagdic, Osman; Yuce, Hande; Yelboga, Emrah

    2017-06-15

    Our work explored, for the first time, monitoring peroxide value (PV) of omega-3 rich algae oil using ATR-FTIR spectroscopic technique. The PV of the developed method was compared by that obtained by standard method of Association of Official Analytical Chemists (AOAC). In this study, peak area integration (PAI), Partial Least Squares Regression (PLSR), and Principal Component Regression (PCR) were used as the calibration techniques. PV obtained by the AOAC method and by FTIR-ATR technique were well correlated considering the peak area related to trans double bonds and chemometrics techniques of PLSR and PCR. Calibration model was established using the band with a peak point at 966cm-1 (990-940cm-1) related to CH out of plane deformation vibration of trans double bond. Algae oil oxidation could be successfully quantified using PAI, PLSR and PCR techniques. Additionally, hierarchical cluster analysis was performed and significant discrimination was observed coherently with oxidation process. Copyright © 2017 Elsevier Ltd. All rights reserved.

  15. ATR-IR fingerprinting as a powerful method for identification of traditional medicine samples: a report of 20 herbal patterns

    Directory of Open Access Journals (Sweden)

    A. Sakhteman

    2015-06-01

    Full Text Available Background and objectives: Attenuated total reflectance-inferared (ATR-IR spectra can be used as a non-invasive fingerprinting approach in quality control of herbal samples. Methods: Twenty versatile herbal samples were subjected to attenuated total reflectance-inferared (ATR-IR spectroscopy followed by different clustering methods in order to determine by which method more reasonable classifications would be obtained. Results: All classification methods (K-means, HCA, PCA and SOM were able to discriminate the two medicinal seeds, Hyocyamus niger and Peganum harmala from other herbal samples. Similarly, the starch samples were clustered in a reasonable method. In HCA, one cluster included three types of starch samples: Zea mays, Oryza sativa and Triticum aestivum. All the four classification methods were able to separate Solanum tuberosum starch from other starch samples. HCA and SOM, were able to classify leaf samples Origanum vulgare and Melissa officinalis belonging to Lamiaceae family, in one category. Crocus sativus and its adulterant Carthamus tinctorius flowers were identified by PCA, HCA and SOM as different categories. Conclusion: The result of this study can be utilized for identification and quality control of traditionally used medicinal plant samples in an unknown sample powder. Such data could be the basis for preparing a data bank on Iranian medicinal samples which in turn is used as a simple, fast and reliable method for characterization of herbal powders in Pharmacopoeias.

  16. Characterization of postmortem biochemical changes in rabbit plasma using ATR-FTIR combined with chemometrics: A preliminary study

    Science.gov (United States)

    Zhang, Ji; Li, Bing; Wang, Qi; Li, Chengzhi; Zhang, Yinming; Lin, Hancheng; Wang, Zhenyuan

    2017-02-01

    Postmortem interval (PMI) determination is one of the most challenging tasks in forensic medicine due to a lack of accurate and reliable methods. It is especially difficult for late PMI determination. Although many attempts with various types of body fluids based on chemical methods have been made to solve this problem, few investigations are focused on blood samples. In this study, we employed an attenuated total reflection (ATR)-Fourier transform infrared (FTIR) technique coupled with principle component analysis (PCA) to monitor biochemical changes in rabbit plasma with increasing PMI. Partial least square (PLS) model was used based on the spectral data for PMI prediction in an independent sample set. Our results revealed that postmortem chemical changes in compositions of the plasma were time-dependent, and various components including proteins, lipids and nucleic acids contributed to the discrimination of the samples at different time points. A satisfactory prediction within 48 h postmortem was performed by the combined PLS model with a good fitting between actual and predicted PMI of 0.984 and with an error of ± 1.92 h. In consideration of the simplicity and portability of ATR-FTIR, our preliminary study provides an experimental and theoretical basis for application of this technique in forensic practice.

  17. PREFACE: 1982 International Conference on Plasma Physics

    Science.gov (United States)

    Wilhelmsson, Hans

    1982-01-01

    second one to (3) Fusion and (4) Laboratory Plasmas. The 1982 International Conference on Plasma Physics was organized by Chalmers University of Technology. It gathered about 500 participants from 40 countries. Large delegations came from the USA, France, West Germany, Japan, the USSR, and India, the number of participants from these countries ranging from 100 to 20. Sweden had about 50 participating scientists. There were a total of about 20 from the other Scandinavian countries. The principal sponsor of the conference was IUPAP, the International Union of Pure and Applied Physics. The conference also had a number of co-sponsors like IAU, the International Astronomical Union, URSI, the International Union of Radio Science, EPS, the European Physical Society, and EURATOM-FUSION. The conference was supported by Swedish Industry and Swedish Research Boards. The previous ICPP, held in Nagoya two years ago, was the first attempt to combine two types of conferences: the Plasma Theory Conference, first held in Kiev in the Soviet Union in 1971, and the Waves and Instabilities Congress, held for the first time in Innsbruck, Austria in 1973. As a consequence of the success of the Nagoya conference it was decided by the International Organizing Committee of the ICPP that the 1982 conference should also be of the combined type. The 1982 ICPP in Göteborg was thus a Joint Conference of the Fifth Kiev International Conference in Plasma Theory and the Fifth International Congress on Waves and Instabilities in Plasmas. During the conference in Göteborg the International Organizing Committee had a meeting and it was decided that also the next International Conference on Plasma Physics will be of the combined type. It will be held in Lausanne, Switzerland in 1984. The International Organizing Committee on the 1982 International Conference on Plasma Physics comprised about 40 plasma physics scientists from all over the world, who represented various sections of plasma physics. I would

  18. Computational Intelligence : International Joint Conference

    CERN Document Server

    Rosa, Agostinho; Cadenas, José; Dourado, António; Madani, Kurosh; Filipe, Joaquim

    2016-01-01

    The present book includes a set of selected extended papers from the sixth International Joint Conference on Computational Intelligence (IJCCI 2014), held in Rome, Italy, from 22 to 24 October 2014. The conference was composed by three co-located conferences:  The International Conference on Evolutionary Computation Theory and Applications (ECTA), the International Conference on Fuzzy Computation Theory and Applications (FCTA), and the International Conference on Neural Computation Theory and Applications (NCTA). Recent progresses in scientific developments and applications in these three areas are reported in this book. IJCCI received 210 submissions, from 51 countries, in all continents. After a double blind paper review performed by the Program Committee, 15% were accepted as full papers and thus selected for oral presentation. Additional papers were accepted as short papers and posters. A further selection was made after the Conference, based also on the assessment of presentation quality and audience in...

  19. Energy Conferences and Symposia; (USA)

    Energy Technology Data Exchange (ETDEWEB)

    Osborne, J.H.; Simpson, W.F. Jr. (eds.)

    1991-01-01

    Energy Conferences and Symposia, a monthly publication, was instituted to keep scientists, engineers, managers, and related energy professionals abreast of meetings sponsored by the Department of Energy (DOE) and by other technical associations. Announcements cover conference, symposia, workshops, congresses, and other formal meetings pertaining to DOE programmatic interests. Complete meeting information, including title, sponsor, and contact, is presented in the main section, which is arranged alphabetically by subject area. Within a subject, citations are sorted by beginning data of the meeting. New listings are indicated by a bullet after the conference number and DOE-sponsored conferences are indicated by a star. Two indexes are provided for cross referencing conference information. The Chronological Index lists conference titles by dates and gives the subject area where complete information they may be found. The Location Index is alphabetically sorted by the city where the conference will be held.

  20. Hepatitis B virus X protein via the p38MAPK pathway induces E2F1 release and ATR kinase activation mediating p53 apoptosis.

    Science.gov (United States)

    Wang, Wen-Horng; Hullinger, Ronald L; Andrisani, Ourania M

    2008-09-12

    Hepatitis B virus (HBV) X protein (pX) is implicated in hepatocellular carcinoma (HCC) pathogenesis by an unknown mechanism. Deletions or mutations of genes involved in the p53 pathway are often associated with HBV-mediated HCC, indicating rescue from p53 apoptosis is a likely mechanism in HBV-HCC pathogenesis. Herein, we determined the mechanism by which pX sensitizes hepatocytes to p53-mediated apoptosis. Although it is well established that the Rb/E2F/ARF pathway stabilizes p53, and the DNA damage-activated ATM/ATR kinases activate p53, the mechanism that coordinates these two pathways has not been determined. We demonstrate that the p38MAPK pathway activated by pX serves this role in p53 apoptosis. Specifically, the activated p38MAPK pathway stabilizes p53 via E2F1-mediated ARF expression, and also activates the transcriptional function of p53 by activating ATR. Knockdown of p53, E2F1, ATR, or p38MAPKalpha abrogates pX-mediated apoptosis, demonstrating that E2F1, ATR, and p38MAPKalpha are all essential in p53 apoptosis in response to pX. Specifically, in response to pX expression, the p38MAPK pathway activates Cdk4 and Cdk2, leading to phosphorylation of Rb, release of E2F1, and transcription of ARF. The p38MAPK pathway also activates ATR, leading to phosphorylation of p53 on Ser-18 and Ser-23, transcription of pro-apoptotic genes Bax, Fas, and Noxa, and apoptosis. In conclusion, pX sensitizes hepatocytes to p53 apoptosis via activation of the p38MAPK pathway, which couples p53 stabilization and p53 activation, by E2F1 induction and ATR activation, respectively.

  1. Hepatitis B Virus X Protein via the p38MAPK Pathway Induces E2F1 Release and ATR Kinase Activation Mediating p53 Apoptosis*S⃞

    Science.gov (United States)

    Wang, Wen-Horng; Hullinger, Ronald L.; Andrisani, Ourania M.

    2008-01-01

    Hepatitis B virus (HBV) X protein (pX) is implicated in hepatocellular carcinoma (HCC) pathogenesis by an unknown mechanism. Deletions or mutations of genes involved in the p53 pathway are often associated with HBV-mediated HCC, indicating rescue from p53 apoptosis is a likely mechanism in HBV-HCC pathogenesis. Herein, we determined the mechanism by which pX sensitizes hepatocytes to p53-mediated apoptosis. Although it is well established that the Rb/E2F/ARF pathway stabilizes p53, and the DNA damage-activated ATM/ATR kinases activate p53, the mechanism that coordinates these two pathways has not been determined. We demonstrate that the p38MAPK pathway activated by pX serves this role in p53 apoptosis. Specifically, the activated p38MAPK pathway stabilizes p53 via E2F1-mediated ARF expression, and also activates the transcriptional function of p53 by activating ATR. Knockdown of p53, E2F1, ATR, or p38MAPKα abrogates pX-mediated apoptosis, demonstrating that E2F1, ATR, and p38MAPKα are all essential in p53 apoptosis in response to pX. Specifically, in response to pX expression, the p38MAPK pathway activates Cdk4 and Cdk2, leading to phosphorylation of Rb, release of E2F1, and transcription of ARF. The p38MAPK pathway also activates ATR, leading to phosphorylation of p53 on Ser-18 and Ser-23, transcription of pro-apoptotic genes Bax, Fas, and Noxa, and apoptosis. In conclusion, pX sensitizes hepatocytes to p53 apoptosis via activation of the p38MAPK pathway, which couples p53 stabilization and p53 activation, by E2F1 induction and ATR activation, respectively. PMID:18606816

  2. Interactions of Human Mismatch Repair Proteins MutSα and MutLα with Proteins of the ATR-Chk1 Pathway*

    Science.gov (United States)

    Liu, Yiyong; Fang, Yanan; Shao, Hongbing; Lindsey-Boltz, Laura; Sancar, Aziz; Modrich, Paul

    2010-01-01

    At clinically relevant doses, chemotherapeutic SN1 DNA methylating agents induce an ATR-mediated checkpoint response in human cells that is dependent on functional MutSα and MutLα. Deficiency of either mismatch repair activity renders cells highly resistant to this class of drug, but the mechanisms linking mismatch repair to checkpoint activation have remained elusive. In this study we have systematically examined the interactions of human MutSα and MutLα with proteins of the ATR-Chk1 pathway using both nuclear extracts and purified proteins. Using nuclear co-immunoprecipitation, we have detected interaction of MutSα with ATR, TopBP1, Claspin, and Chk1 and interaction of MutLα with TopBP1 and Claspin. We were unable to detect interaction of MutSα or MutLα with Rad17, Rad9, or replication protein A in the extract system. Use of purified proteins confirmed direct interaction of MutSα with ATR, TopBP1, and Chk1 and of MutLα with TopBP1. MutSα-Claspin and MutLα-Claspin interactions were not demonstrable with purified proteins, suggesting that extract interactions are indirect or depend on post-translational modification. Use of a modified chromatin immunoprecipitation assay showed that proliferating cell nuclear antigen, ATR, TopBP1, and Chk1 are recruited to chromatin in a MutLα- and MutSα-dependent fashion after N-methyl-N′-nitro-N-nitrosoguanidine treatment. However, chromatin enrichment of replication protein A, Claspin, Rad17-RFC, and Rad9-Rad1-Hus1 was not detected in these experiments. Although our failure to observe enrichment of the latter activities could be due to sensitivity limitations, these observations may indicate a novel mechanism for ATR activation. PMID:20029092

  3. IEEE conference record -- Abstracts

    Energy Technology Data Exchange (ETDEWEB)

    1994-01-01

    This conference covers the following areas: computational plasma physics; vacuum electronic; basic phenomena in fully ionized plasmas; plasma, electron, and ion sources; environmental/energy issues in plasma science; space plasmas; plasma processing; ball lightning/spherical plasma configurations; plasma processing; fast wave devices; magnetic fusion; basic phenomena in partially ionized plasma; dense plasma focus; plasma diagnostics; basic phenomena in weakly ionized gases; fast opening switches; MHD; fast z-pinches and x-ray lasers; intense ion and electron beams; laser-produced plasmas; microwave plasma interactions; EM and ETH launchers; solid state plasmas and switches; intense beam microwaves; and plasmas for lighting. Separate abstracts were prepared for 416 papers in this conference.

  4. Indico CONFERENCE tutorial

    CERN Multimedia

    CERN. Geneva; Manzoni, Alex Marc

    2017-01-01

    This short tutorial explains how to create a CONFERENCE in indico and how to handle abstracts and registration forms, in detail: Timestamps: 1:01 - Programme  2:28 - Call for abstracts  11:50 - Abstract submission  13:41 - Abstract Review 15:41 - The Judge's Role 17:23 - Registration forms' creation 23:34 - Candidate participant's registration/application 25:54 - Customisation of Indico pages - Layout 28:08 - Customisation of Indico pages - Menus 29:47 - Configuring Event reminders and import into calendaring tools   See HERE a recent presentation by Pedro about the above steps in the life of an indico CONFERENCE event.

  5. Mississippi Climate & Hydrology Conference

    Energy Technology Data Exchange (ETDEWEB)

    Lawford, R.; Huang, J.

    2002-05-01

    The GEWEX Continental International Project (GCIP), which started in 1995 and completed in 2001, held its grand finale conference in New Orleans, LA in May 2002. Participants at this conference along with the scientists funded through the GCIP program are invited to contribute a paper to a special issue of Journal of Geophysical Research (JGR). This special JGR issue (called GCIP3) will serve as the final report on scientific research conducted by GCIP investigators. Papers are solicited on the following topical areas, but are not limited to, (1) water energy budget studies; (2) warm season precipitation; (3) predictability and prediction system; (4) coupled land-atmosphere models; (5) climate and water resources applications. The research areas cover observations, modeling, process studies and water resources applications.

  6. Metabolic Engineering VII Conference

    Energy Technology Data Exchange (ETDEWEB)

    Kevin Korpics

    2012-12-04

    The aims of this Metabolic Engineering conference are to provide a forum for academic and industrial researchers in the field; to bring together the different scientific disciplines that contribute to the design, analysis and optimization of metabolic pathways; and to explore the role of Metabolic Engineering in the areas of health and sustainability. Presentations, both written and oral, panel discussions, and workshops will focus on both applications and techniques used for pathway engineering. Various applications including bioenergy, industrial chemicals and materials, drug targets, health, agriculture, and nutrition will be discussed. Workshops focused on technology development for mathematical and experimental techniques important for metabolic engineering applications will be held for more in depth discussion. This 2008 meeting will celebrate our conference tradition of high quality and relevance to both industrial and academic participants, with topics ranging from the frontiers of fundamental science to the practical aspects of metabolic engineering.

  7. UKSG Annual Conference 2012

    Directory of Open Access Journals (Sweden)

    Gopal Dutta

    2012-07-01

    Full Text Available UKSG offered four free places for students to attend the 2012 Conference, made possible with generous support from Elsevier, whose contribution is very much appreciated. Those eligible to apply were students enrolled on Library & Information and Publishing degree courses, and the successful applicants were (Ieft to right as photographed against the River Clyde: Stuart Lawson (University of Brighton, Jennifer Lovatt (Oxford Brookes University, Gopal Dutta (University of Sheffield and Lydia Lantzsch (Oxford Brookes University. The four have allowed us to take a peek at the diaries they kept during the conference. The extracts below give us a flavour of the event including the plenary and breakout sessions, the debates and the stamina of those who kept the dancing going!

  8. 2013 APPLEPIES Conference

    CERN Document Server

    2014-01-01

    This book provides a thorough overview of cutting-edge research on electronics applications relevant to industry, the environment, and society at large. A wide spectrum of application domains are covered, from automotive to space and from health to security, and special attention is devoted to the use of embedded devices and sensors for imaging, communication, and control. The book is based on the 2013 APPLEPIES Conference, held in Rome, which brought together researchers and stakeholders to consider the most significant current trends in the field of applied electronics and to debate visions for the future. Areas covered by the conference included information communication technology; biotechnology and biomedical imaging; space; secure, clean, and efficient energy; the environment; and smart, green, and integrated transport. As electronics technology continues to develop apace, constantly meeting previously unthinkable targets, further attention needs to be directed toward the electronics applications and th...

  9. 7th IAASS Conference

    CERN Document Server

    Rongier, Isabelle

    2015-01-01

    The 7th IAASS Conference, “Space Safety is No Accident” is an invitation to reflect and exchange information on a number of topics in space safety and sustainability of national and international interest. The conference is also a forum to promote mutual understanding, trust and the widest possible international cooperation in such matters. The once exclusive “club” of nations with autonomous sub-orbital and orbital space access capabilities is becoming crowded with fresh and ambitious new entrants. New commercial spaceports are starting operations and others are being built. In the manned spaceflight arena a commercial market is becoming a tangible reality with suborbital spaceflights and government use of commercial services for cargo and crew transportation to orbit. Besides the national ambitions in space, the international cooperation both civil and commercial is also gaining momentum. In the meantime robotic space exploration will accelerate and with it the need to internationally better regulat...

  10. Development of C-lignin with G/S-lignin and lipids in orchid seed coats – an unexpected diversity exposed by ATR-FT-IR spectroscopy

    DEFF Research Database (Denmark)

    Barsberg, Søren Talbro; Lee, Y-I; Rasmussen, Hanne Nina

    2018-01-01

    Cite this article: Barsberg ST, Lee Y-I, Rasmussen HN. Development of C-lignin with G/S-lignin and lipids in orchid seed coats – an unexpected diversity exposed by ATR-FT-IR spectroscopy. Seed Science Research https:// doi.org/10.1017/S0960258517000344......Cite this article: Barsberg ST, Lee Y-I, Rasmussen HN. Development of C-lignin with G/S-lignin and lipids in orchid seed coats – an unexpected diversity exposed by ATR-FT-IR spectroscopy. Seed Science Research https:// doi.org/10.1017/S0960258517000344...

  11. In Vivo and In Vitro Effects of ATM/ATR Signaling Pathway on Proliferation, Apoptosis, and Radiosensitivity of Nasopharyngeal Carcinoma Cells.

    Science.gov (United States)

    Wang, Ming; Liu, Gang; Shan, Guo-Ping; Wang, Bing-Bing

    2017-08-01

    The study investigated the ability of ataxia-telangiectasia mutated (ATM)/Rad3-related (ATR) signaling pathway to influence the proliferation, apoptosis, and radiosensitivity of nasopharyngeal carcinoma (NPC) cells. NPC tissues and corresponding adjacent normal tissues were collected from 143 NPC patients. The NPC CNE2 cells were assigned into a control group, X-ray group, CGK-733 group, and X-ray+CGK-733 group. The mRNA levels of ATM and ATR were evaluated using quantitative real-time polymerase chain reaction (qRT-PCR) and the protein levels of ATM and ATR using western blotting. The positive expression of ATM and ATR in tissues and nude mouse tumor tissues was determined by immunohistochemistry. Cell proliferation, migration, invasion, and apoptosis rates were analyzed by the 3-(4,5)-dimethylthiahiazo (-z-y1)-3,5-di- phenytetrazoliumromide (MTT) assay, scratch test, transwell assay, and flow cytometry, respectively. A nude mouse model of NPC was established to observe tumor volume and growth. The mRNA levels of ATR and ATM and the expression of ATR and ATM protein in NPC tissues were significantly higher than those in adjacent normal tissues. The colony formation assay showed that the colony-forming rate decreased, showing radiation dose-dependent and CGK-733 concentration-dependent manners. Expression of ATM, ATR, Chk1, and Chk2 was evidently increased in the X-ray, CGK-733, and X-ray+CGK-733groups compared with the control group, and the aforementioned expression was highest in the X-ray+CGK-733 group among the four groups. The cell proliferation, invasion, and migration were decreased, tumor volume decreased and cell apoptosis increased in the X-ray, CGK-733, and X-ray+CGK-733 groups compared with the control group; the X-ray+CGK-733 group exhibited lowest cell proliferation, invasion and migration, smallest tumor volume, and highest cell apoptosis among the four groups. Inhibition of ATM/ATR signaling pathway reduces proliferation and enhances apoptosis and

  12. Putting the World into World History Textbooks.

    Science.gov (United States)

    Paquette, William A.

    2001-01-01

    Reviews whether textbook publishers have put the "world" in world history textbooks by comparing the editions of four different world history textbooks over 25 years. Evaluates 10 current editions of world history textbooks. Offers questions to consider and discusses additional content concerns. Includes charts and references of the reviewed…

  13. 2004 Mutagenesis Gordon Conference

    Energy Technology Data Exchange (ETDEWEB)

    Dr. Sue Jinks-Robertson

    2005-09-16

    Mutations are genetic alterations that drive biological evolution and cause many, if not all, human diseases. Mutation originates via two distinct mechanisms: ''vertical'' variation is de novo change of one or few bases, whereas ''horizontal'' variation occurs by genetic recombination, which creates new mosaics of pre-existing sequences. The Mutagenesis Conference has traditionally focused on the generation of mutagenic intermediates during normal DNA synthesis or in response to environmental insults, as well as the diverse repair mechanisms that prevent the fixation of such intermediates as permanent mutations. While the 2004 Conference will continue to focus on the molecular mechanisms of mutagenesis, there will be increased emphasis on the biological consequences of mutations, both in terms of evolutionary processes and in terms of human disease. The meeting will open with two historical accounts of mutation research that recapitulate the intellectual framework of this field and thereby place the current research paradigms into perspective. The two introductory keynote lectures will be followed by sessions on: (1) mutagenic systems, (2) hypermutable sequences, (3) mechanisms of mutation, (4) mutation avoidance systems, (5) mutation in human hereditary and infectious diseases, (6) mutation rates in evolution and genotype-phenotype relationships, (7) ecology, mutagenesis and the modeling of evolution and (8) genetic diversity of the human population and models for human mutagenesis. The Conference will end with a synthesis of the meeting as the keynote closing lecture.

  14. Conference on Logical Methods

    CERN Document Server

    Remmel, Jeffrey; Shore, Richard; Sweedler, Moss; Progress in Computer Science and Applied Logic

    1993-01-01

    The twenty-six papers in this volume reflect the wide and still expanding range of Anil Nerode's work. A conference on Logical Methods was held in honor of Nerode's sixtieth birthday (4 June 1992) at the Mathematical Sciences Institute, Cornell University, 1-3 June 1992. Some of the conference papers are here, but others are from students, co-workers and other colleagues. The intention of the conference was to look forward, and to see the directions currently being pursued, in the development of work by, or with, Nerode. Here is a brief summary of the contents of this book. We give a retrospective view of Nerode's work. A number of specific areas are readily discerned: recursive equivalence types, recursive algebra and model theory, the theory of Turing degrees and r.e. sets, polynomial-time computability and computer science. Nerode began with automata theory and has also taken a keen interest in the history of mathematics. All these areas are represented. The one area missing is Nerode's applied mathematica...

  15. Conference proceedings of the first international conference on mental health, March 2012

    Directory of Open Access Journals (Sweden)

    Khalily MT

    2012-09-01

    Full Text Available Muhammad Tahir Khalily, Seema Gul, Uzma MasroorDepartment of Psychology, International Islamic University, Islamabad (IIUI, PakistanThere has been an alarming increase in mental illness reflected in a persistent wave of violence, suicide, deliberate self-harm, and disruption in the social fabric worldwide, and particularly in Pakistan, a developing country and now the ninth most populous in the world.Keeping in view the abovementioned mental health issues, the Department of Psychology, Faculty of Social Sciences, International Islamic University, organized the first international conference on mental health, held on March 29–30, 2012, with the theme "Violence, psychological trauma, and possible acute and post-traumatic interventions in general and particularly in Pakistani society", to enable intellectual and academic circles to acquire a profound understanding of mental health issues and develop evidence-based strategies for the amelioration of psychological ailments.The chief invited guest at this inaugural conference was Sohail Naqvi, executive director of the Higher Education Commission, accompanied by Dr Mumtaz Ahmed, president of the International Islamic University, Islamabad, Nabi Bux Jumani, dean of the Faculty of Social Science, Muhammad Tahir Khalily, chairman and principal conference organizer, from the Department of Psychology, and Seema Gul, the coprincipal conference organizer. Tahir Khalily, the principal organizer, gave the welcome address, highlighting the prevalence of mental health problems in Pakistan as a consequence of violence. In addition, he lauded the support of the International Islamic University and Higher Education Commission in organizing this auspicious event.

  16. World Energy Outlook 2008

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2006-11-07

    will be willing to make investments themselves or to attract sufficient capital to keep up the necessary pace of investment. Upstream investment has been rising rapidly in the last few years, but much of the increase is due to surging costs. Expanding production in the lowest-cost countries - most of them in OPEC - will be central to meeting the world's oil needs at reasonable cost. The prospect of accelerating declines in production at individual oilfields is adding to these uncertainties. The findings of an unprecedented field-by-field analysis of the historical production trends of 800 oilfields indicate that decline rates are likely to rise significantly in the long term, from an average of 6.7% today to 8.6% in 2030. WEO-2008 also analyses policy options for tackling climate change after 2012, when a new global agreement - to be negotiated at the UN Conference of the Parties in Copenhagen next year - is due to take effect. This analysis assumes a hybrid policy approach, comprising a plausible combination of cap-and-trade systems, sectoral agreements and national measures. On current trends, energy-related CO2 emissions are set to increase by 45% between 2006 and 2030, reaching 41 Gt. Three-quarters of the increase arises in China, India and the Middle East, and 97% in non-OECD countries as a whole. Stabilising greenhouse gas concentration at 550 ppm of CO2-equivalent, which would limit the temperature increase to about 3 deg C, would require emissions to rise to no more than 33 Gt in 2030 and to fall in the longer term. The share of low-carbon energy - hydropower, nuclear, biomass, other renewables and fossil-fuel power plants equipped with carbon capture and storage (CCS) - in the world primary energy mix would need to expand from 19% in 2006 to 26% in 2030. This would call for $4.1 trillion more investment in energy-related infrastructure and equipment than in the Reference Scenario - equal to 0.2% of annual world GDP. Most of the increase is on the demand

  17. A new Density Functional Theory (DFT) based method for supporting the assignment of vibrational signatures of mannan and cellulose—Analysis of palm kernel cake hydrolysis by ATR-FT-IR spectroscopy as a case study

    DEFF Research Database (Denmark)

    Barsberg, Søren Talbro; Sanadi, Anand Ramesh; Jørgensen, Henning

    2011-01-01

    Attenuated Total Reflectance (ATR) FT-IR spectroscopy gives in situ information on molecular concentration, organization and interactions in plant cell walls. We demonstrate its potential for further developments by a case study which combines ATR-FT-IR spectroscopy with a recently published DFT ...

  18. 2010 Membranes: Materials & Processes Gordon Research Conference

    Energy Technology Data Exchange (ETDEWEB)

    Jerry Lin

    2010-07-30

    The GRC series on Membranes: Materials and Processes have gained significant international recognition, attracting leading experts on membranes and other related areas from around the world. It is now known for being an interdisciplinary and synergistic meeting. The next summer's edition will keep with the past tradition and include new, exciting aspects of material science, chemistry, chemical engineering, computer simulation with participants from academia, industry and national laboratories. This edition will focus on cutting edge topics of membranes for addressing several grand challenges facing our society, in particular, energy, water, health and more generally sustainability. During the technical program, we want to discuss new membrane structure and characterization techniques, the role of advanced membranes and membrane-based processes in sustainability/environment (including carbon dioxide capture), membranes in water processes, and membranes for biological and life support applications. As usual, the informal nature of the meeting, excellent quality of the oral presentations and posters, and ample opportunity to meet many outstanding colleagues make this an excellent conference for established scientists as well as for students. A Gordon Research Seminar (GRS) on the weekend prior to the GRC meeting will provide young researchers an opportunity to present their work and network with outstanding experts. It will also be a right warm-up for the conference participants to join and enjoy the main conference.

  19. Science journalists learn of scientific renaissance at Doha conference

    CERN Document Server

    James Gillies

    2011-01-01

    Last week, over 700 science journalists from around the world made their way to Doha, Qatar, for the World Conference of Science Journalists. This meeting takes place every two years, and is the largest gathering of science writers in the world. Established in the early 1990s, this is the first time that a Middle Eastern country has hosted the conference, and it was quite an eye opener.   American-Egyptian Nobel Prize winner Ahmed Zewail delivers a keynote address at the World Conference of Science Journalists. Firstly, the large number of participants shows clearly that reports of the demise of science journalism seem to have been widely exaggerated. But it’s not only the number or participants that’s impressive: it’s also where they came from. Thanks in part to grants from the Qatar Foundation, 90 countries were represented with around 50% of participants coming from the developing world. One real eye-opener was the state of science in the Middle East. Originally s...

  20. World Sustainable Energy Days Next 2014

    CERN Document Server

    Egger, Christiane

    2015-01-01

    These conference proceedings contain contributions to one of Europe’s largest annual conferences on energy efficiency and renewable energy. From two main fields – biomass and energy efficiency in buildings – contributions offer an insight into the research work and the scientific findings and developments of young researchers from all over the world. The papers were selected by a high-level scientific committee for oral presentation. They also communicate results, trends and opinions that will concern and influence the world’s energy experts and policy makers over the next decades. The conference was held from 26-27 February 2014. The conference The conference is organized by the Energy Agency of Upper Austria (OÖ Energiesparverband) and held in Wels annually in February or March. It attracts more than 700 experts from over 50 countries every year. The Editors Christiane Egger is the deputy managing director of the OÖ Energiesparverband and the Manager of the Ökoenergie-Cluster, a network of 160 co...

  1. PREFACE: Wake Conference 2015

    Science.gov (United States)

    Barney, Andrew; Nørkær Sørensen, Jens; Ivanell, Stefan

    2015-06-01

    The 44 papers in this volume constitute the proceedings of the 2015 Wake Conference, held in Visby on the island of Gotland in Sweden. It is the fourth time this conference has been held. The Wake Conference series started in Visby, where it was held in 2009 and 2011. In 2013 it took place in Copenhagen where it was combined with the International Conference on Offshore Wind Energy and Ocean Energy. In 2015 it is back where it started in Visby, where it takes place at Uppsala University Campus Gotland, June 9th-11th. The global yearly production of electrical energy by wind turbines has grown tremendously in the past decade and it now comprises more than 3% of the global electrical power consumption. Today the wind power industry has a global annual turnover of more than 50 billion USD and an annual average growth rate of more than 20%. State-of-the-art wind turbines have rotor diameters of up to 150 m and 8 MW installed capacity. These turbines are often placed in large wind farms that have a total production capacity corresponding to that of a nuclear power plant. In order to make a substantial impact on one of the most significant challenges of our time, global warming, the industry's growth has to continue for a decade or two yet. This in turn requires research into the physics of wind turbine wakes and wind farms. Modern wind turbines are today clustered in wind farms in which the turbines are fully or partially influenced by the wake of upstream turbines. As a consequence, the wake behind the wind turbines has a lower mean wind speed and an increased turbulence level, as compared to the undisturbed flow outside the farm. Hence, wake interaction results in decreased total production of power, caused by lower kinetic energy in the wind, and an increase in the turbulence intensity. Therefore, understanding the physical nature of the vortices and their dynamics in the wake of a turbine is important for the optimal design of a wind farm. This conference is aimed

  2. Sleepwalking into a problem. Peak oil conference in Cork, Ireland

    Energy Technology Data Exchange (ETDEWEB)

    Koppelaar, R.

    2007-11-15

    At the sixth annual conference of the Association for the Study of Peak Oil and Gas (ASPO), which was held in Cork, Ireland, September 17-18, 2007, experts from all over the world gathered to discuss energy trends and the implications this has on the world's future. It appears that the world needs to develop policies for oil conservation and implement renewable energy strategies. The following two questions were discussed: (1) is the oil situation really that dire?; and (2) if so, how can the challenge of diminishing oil supply be met.

  3. 8th International Robotic Sailing Conference

    CERN Document Server

    Haug, Florian

    2016-01-01

    This book presents the cutting edge developments within a broad field related to robotic sailing. The contributions were presented during the 8th International Robotic Sailing Conference, which has taken place as a part of the 2015 World Robotic Sailing Championships in Mariehamn, Åland (Finland), August 31st – September 4th 2015. Since more than a decade, a series of competitions such as the World Robotic Sailing Championship have stimulated a variety of groups to work on research and development around autonomous sailing robots, which involves boat designers, naval architects, electrical engineers and computer scientists. While many of the challenges in building a truly autonomous sailboat are still unsolved, the books presents the state of the art of research and development within platform optimization, route and stability planning, collision avoidance, power management and boat control.

  4. Conference Report: The First ATLAS.ti User Conference

    Directory of Open Access Journals (Sweden)

    Jeanine C. Evers

    2014-01-01

    Full Text Available This report on the First ATLAS.ti User Conference shares our impressions and experiences as longstanding ATLAS.ti users and trainers about the First ATLAS.ti User Conference in Berlin 2013. The origins, conceptual principles and development of the program are outlined, the conference themes discussed and experiences shared. Finally, the future of the program is discussed. URN: http://nbn-resolving.de/urn:nbn:de:0114-fqs1401197

  5. Conference Report: 5th Annual Georgia Conference on Information Literacy

    OpenAIRE

    Rebecca Ziegler; Mark Lewis Richardson

    2009-01-01

    The 5th annual Georgia Conference on Information Literacy took place in Savannah, Georgia on October 3-4, 2008. Since its inception, this conference has drawn participants from across the United States and even a few from abroad. Jointly sponsored by the Zach S. Henderson Library, the Department of Writing and Linguistics, the College of Education, and the Center for Continuing Education at Georgia Southern University, the conference offers both theoretical and practical discussions of the c...

  6. 2014 International Conference on Manufacturing, Optimization, Industrial and Material Engineering

    Science.gov (United States)

    Lumban Gaol, Ford; Webb, Jeff; Ding, Jun

    2014-06-01

    The 2nd International Conference on Manufacturing, Optimization, Industrial and Material Engineering 2014 (MOIME 2014), was held at the Grand Mercure Harmoni, Opal Room 3rd Floor, Jakarta, Indonesia, during 29-30 March 2014. The MOIME 2014 conference is designed to bring together researchers, engineers and scientists in the domain of interest from around the world. MOIME 2014 is placed on promoting interaction between the theoretical, experimental, and applied communities, so that a high level exchange is achieved in new and emerging areas within Material Engineering, Industrial Engineering and all areas that relate to Optimization. We would like to express our sincere gratitude to all in the Technical Program Committee who have reviewed the papers and developed a very interesting Conference Program as well as the invited and plenary speakers. This year, we received 97 papers and after rigorous review, 24 papers were accepted. The participants come from 7 countries. There are 4 (four) parallel session and 2 Invited Speakers and one workshop. It is an honour to present this volume of IOP Conference Series: Materials Science and Engineering (MSE) and we deeply thank the authors for their enthusiastic and high-grade contributions. Finally, we would like to thank the conference chairmen, the members of the steering committee, the organizing committee, the organizing secretariat and the financial support from the conference sponsors that allowed the success of MOIME 2014. The Editors of the MOIME 2014 Proceedings Editors Dr Ford Lumban Gaol Jeff Webb, PhD Professor Jun Ding, PhD

  7. Dynamic dependence on ATR and ATM for double-strand break repair in human embryonic stem cells and neural descendants.

    Directory of Open Access Journals (Sweden)

    Bret R Adams

    2010-04-01

    Full Text Available The DNA double-strand break (DSB is the most toxic form of DNA damage. Studies aimed at characterizing DNA repair during development suggest that homologous recombination repair (HRR is more critical in pluripotent cells compared to differentiated somatic cells in which nonhomologous end joining (NHEJ is dominant. We have characterized the DNA damage response (DDR and quality of DNA double-strand break (DSB repair in human embryonic stem cells (hESCs, and in vitro-derived neural cells. Resolution of ionizing radiation-induced foci (IRIF was used as a surrogate for DSB repair. The resolution of gamma-H2AX foci occurred at a slower rate in hESCs compared to neural progenitors (NPs and astrocytes perhaps reflective of more complex DSB repair in hESCs. In addition, the resolution of RAD51 foci, indicative of active homologous recombination repair (HRR, showed that hESCs as well as NPs have high capacity for HRR, whereas astrocytes do not. Importantly, the ATM kinase was shown to be critical for foci formation in astrocytes, but not in hESCs, suggesting that the DDR is different in these cells. Blocking the ATM kinase in astrocytes not only prevented the formation but also completely disassembled preformed repair foci. The ability of hESCs to form IRIF was abrogated with caffeine and siRNAs targeted against ATR, implicating that hESCs rely on ATR, rather than ATM for regulating DSB repair. This relationship dynamically changed as cells differentiated. Interestingly, while the inhibition of the DNA-PKcs kinase (and presumably non-homologous endjoining [NHEJ] in astrocytes slowed IRIF resolution it did not in hESCs, suggesting that repair in hESCs does not utilize DNA-PKcs. Altogether, our results show that hESCs have efficient DSB repair that is largely ATR-dependent HRR, whereas astrocytes critically depend on ATM for NHEJ, which, in part, is DNA-PKcs-independent.

  8. Efficacy of metformin in human single hair fibre by ATR-FTIR spectroscopy coupled with statistical analysis.

    Science.gov (United States)

    Sundaramoorthi, Kamatchi; Sethu, Gunasekaran; Ethirajulu, Sailatha; Raja Marthandam, Pavithra

    2017-03-20

    Diabetes mellitus is chronic metabolic disorder, resulting from insulin deficiency, characterized by hyperglycemia altered metabolism of carbohydrates, proteins and lipids and an increased risk of vascular complications. There are different classes of anti-diabetic drugs in allopathic system of medicine. Metformin (dimethyl biguanide) is a blood glucose lowering agent used in the treatment of non-insulin dependent diabetes mellitus. Almost in all diseases the blood serves as the primary metabolic transport system in the body. Its composition is the preferred indicator with respect to the pathophysiological condition of the patient. Instead of analyzing blood to diagnose diabetes, hair could be used to detect diabetes using FTIR-ATR technique. The most important components of hair are fibrous proteins (keratins), melanins, glycogen, and lipids. Hair follicles are located 3-4mm below the surface of the skin and are surrounded by rich blood capillary system. In the present study, ten diabetic subjects were considered to evaluate the efficacy of metformin hydrochloride for the treatment of diabetes mellitus using FTIR-ATR spectroscopy. The spectra of diabetic hair fibre samples have been recorded in the mid infrared region of 4000-450cm -1 . The hair samples of the diabetic subjects before medication were taken as pre-treatment samples. The hair samples of diabetic subjects referred to medication with metformin for a period of three month were taken as post-treatment sample. Some remarkable spectral differences were elucidated between pre- and post-treatment hair fibre samples. A comparative study on the FTIR-ATR hair spectra of patients (pre- and post-treatment) along with the healthy subjects has been made. The absorption values of some of the specific bands of biomolecules present in the hair samples viz., protein, lipids and glucose for both the pre- and post-treatment subjects are noted. It was observed that, these biomarkers are significantly different between

  9. International Conference on Materials Science and Technology (ICMST 2012)

    Science.gov (United States)

    Joseph, Ginson P.

    2015-02-01

    FROM THE CONVENOR'S DESK The Department of Physics, St. Thomas College Pala, is highly privileged to organize an International Conference on Materials Science and Technology (ICMST 2012) during 10-14 June 2012, and as Convenor of the conference it is with legitimate pride and immense gratitude to God that I remember the most enthusiastic responses received for this from scientists all over the world. In a time of tremendous revolutionary changes in Materials Science and Technology, it is quite in keeping with the tradition of a pioneering institute that St. Thomas College is, to have risen to the occasion to make this conference a reality. We have no doubt that this proved to be a historic event, a real breakthrough, not only for us the organizers but also for all the participants. A conference of this kind provides a nonpareil, a distinctly outstanding platform for the scholars, researchers and the scientists to discuss and share ideas with delegates from all over the world. This had been most fruitful to the participants in identifying new collaborations and strengthening existing relations. That experts of diverse disciplines from across the world were sitting under one roof for five days, exchanging views and sharing findings, was a speciality of this conference. The event has evoked excellent responses from all segments of the Materials Science community worldwide. 600 renowned scholars from 28 countries participated in this. We were uniquely honoured to have Prof. C.N.R. Rao, Chairman, Scientific Advisory Council to the Prime Minister of India, to inaugurate this conference. May I take this opportunity to thank all those who have contributed their valuable share, diverse in tone and nature, in the making of this conference. My whole hearted gratitude is due to the international and national members of the advisory committee for their valuable guidance and involvement. I place on record my heartfelt gratitude to our sponsors. I am sure that this conference has

  10. New frontiers for tomorrow`s world

    Energy Technology Data Exchange (ETDEWEB)

    Kassler, P. [Shell International Petroleum Co. Ltd., London (United Kingdom)

    1994-12-31

    The conference paper deals with new frontiers and barricades in the global economic development and their influence on fuel consumption and energy source development. Topics discussed are incremental energy supply - new frontiers, world car population - new frontiers, OPEC crude production capacity vs call on OPEC, incremental world oil demand by region 1992-2000, oil resource cost curve, progress in seismic 1983-1991, Troll picture, cost reduction in renewables, sustained growth scenario, nuclear electricity capacity - France, OECD road transport fuels - barricades, and energy taxation. 18 figs.

  11. Computational Intelligence : International Joint Conference

    CERN Document Server

    Dourado, António; Rosa, Agostinho; Filipe, Joaquim; Kacprzyk, Janusz

    2016-01-01

    The present book includes a set of selected extended papers from the fifth International Joint Conference on Computational Intelligence (IJCCI 2013), held in Vilamoura, Algarve, Portugal, from 20 to 22 September 2013. The conference was composed by three co-located conferences:  The International Conference on Evolutionary Computation Theory and Applications (ECTA), the International Conference on Fuzzy Computation Theory and Applications (FCTA), and the International Conference on Neural Computation Theory and Applications (NCTA). Recent progresses in scientific developments and applications in these three areas are reported in this book. IJCCI received 111 submissions, from 30 countries, in all continents. After a double blind paper review performed by the Program Committee, only 24 submissions were accepted as full papers and thus selected for oral presentation, leading to a full paper acceptance ratio of 22%. Additional papers were accepted as short papers and posters. A further selection was made after ...

  12. Joint US/German Conference

    CERN Document Server

    Gulledge, Thomas; Jones, Albert

    1993-01-01

    This proceedings volume contains selected and refereed contributions that were presented at the conference on "Recent Developments and New Perspectives of Operations Research in the Area of Production Planning and Control" in Hagen/Germany, 25. - 26. June 1992. This conference was organized with the cooperation of the FernuniversiHit Hagen and was jointly hosted by the "Deutsche Gesellschaft fur Operations Research (DGOR)" and the "Manufacturing Special Interest Group of the Operations Research Society of America (ORSA-SIGMA)". For the organization of the conference we received generous financial support from the sponsors listed at the end of this volume. We wish to express our appreciation to all supporters for their contributions. This conference was the successor of the JOInt ORSA/DGOR-conference in Gaithersburg/Maryland, USA, on the 30. and 31. July 1991. Both OR-societies committed themselves in 1989 to host joint conferences on special topics of interest from the field of operations research. This goal ...

  13. 5th Computer Science On-line Conference

    CERN Document Server

    Senkerik, Roman; Oplatkova, Zuzana; Silhavy, Petr; Prokopova, Zdenka

    2016-01-01

    This volume is based on the research papers presented in the 5th Computer Science On-line Conference. The volume Artificial Intelligence Perspectives in Intelligent Systems presents modern trends and methods to real-world problems, and in particular, exploratory research that describes novel approaches in the field of artificial intelligence. New algorithms in a variety of fields are also presented. The Computer Science On-line Conference (CSOC 2016) is intended to provide an international forum for discussions on the latest research results in all areas related to Computer Science. The addressed topics are the theoretical aspects and applications of Computer Science, Artificial Intelligences, Cybernetics, Automation Control Theory and Software Engineering.

  14. Summary of the AIVC-TightVent Conference 2012

    DEFF Research Database (Denmark)

    Heiselberg, Per Kvols; de Gids, Willem; Janssens, Arnold

    2013-01-01

    , as well as on developments of ventilation requirements based on health. The programme included presentations of invited world-renowned and key experts as well as 75 papers selected from the call for abstracts for long- and short-oral presentations. The conference was organized by the International Network......The conference focused on ventilation and infiltration in nearly zero-energy buildings and more particularly on challenges and perspectives for ventilative cooling (the use of ventilation systems to cool indoor spaces), on the rationale and solutions for better building and ductwork airtightness...

  15. Sixth International Conference on X-ray Microscopy

    Energy Technology Data Exchange (ETDEWEB)

    Robinson, Arthur L.

    1999-08-23

    More than 180 participants from around the world crowded the Clark Kerr Campus of the University of California, Berkeley, from August 1-6, 1999 for the Sixth International Conference on X-Ray Microscopy (XRM99). Held every three years since 1983, the XRM conferences have become the primary international forum for the presentation and discussion of advances in high-spatial-resolution x-ray imaging and applications (including the use of x-ray spectroscopic and analytical techniques) in biological and medical sciences, environmental and soil sciences, and materials and surface sciences.

  16. Middle East in World War II

    Directory of Open Access Journals (Sweden)

    V I Yurtaev

    2015-12-01

    Full Text Available The author considers the role and importance of the region of the Middle East and North African theater of operations during World War II, not only the battles occured in the region are analyzed, but also the diplomatic efforts of the allies, related to the region. Author shows the role of the North African theater of operations in the context of other battles, parses the Allied landing operation called «Torch». Particular attention is given to the Conference of the three Allied leaders during World War II - Stalin (USSR, Roosevelt (USA and Churchill (UK, which was held in Tehran on November 28 - December 1, 1943. The author focuses on the psychological aspects of the conference, emphasizing that it was in the nature of the meeting of equal members of one family. The article also dismantled symbolic importance of presenting to the people of Stalingrad, on behalf of King George VI and the English people specially made sword on November 29, 1943 in the conference hall of the Soviet embassy in Tehran. According to the analysis, the author emphasizes the special importance of the region of the Middle East as a place to search for compromises on the way to the future world order.

  17. International conference on string theory

    CERN Document Server

    2017-01-01

    The Strings 2017 conference is part of the "Strings" series of annual conferences, that bring the entire string theory community together. It will include reviews of major developments in the field, and specialized talks on specific topics. There will also be several public lectures given by conference participants, a pre-Strings school at the Technion, and a post-Strings workshop at the Weizmann Institute.

  18. 14th International Cryocooler Conference

    CERN Document Server

    Ross, Ronald G

    2007-01-01

    This is the 14th volume in the conference series. Over the years the International Cryocoolers Conference has become the preeminent worldwide conference for the presentation of the latest developments and test experiences with cryocoolers. The typical applications of this technology include cooling space and terrestrial infrared focal plane arrays, space x-ray detectors, medical applications, and a growing number of high-temperature superconductor applications.

  19. 15th International Cryocooler Conference

    CERN Document Server

    Ross, Ronald G

    2009-01-01

    This is the 15th volume in the conference series. Over the years the International Cryocooler Conference has become the preeminent worldwide conference for the presentation of the latest developments and test experiences with cryocoolers. The typical applications of this technology include cooling space and terrestrial infrared focal plane arrays, space x-ray detectors, medical applications, and a growing number of high-temperature superconductor applications.

  20. 2nd UNet conference

    CERN Document Server

    Menasche, Daniel; Sabir, Essaïd; Pellegrini, Francesco; Benjillali, Mustapha

    2017-01-01

    This volume offers the proceedings of the 2nd UNet conference, held in Casablanca May 30 - June 1, 2016. It presents new trends and findings in hot topics related to ubiquitous computing/networking, covered in three tracks and three special sessions: Main Track 1: Context-Awareness and Autonomy Paradigms Track Main Track 2: Mobile Edge Networking and Virtualization Track Main Track 3: Enablers, Challenges and Applications Special Session 1: Smart Cities and Urban Informatics for Sustainable Development Special Session 2: Unmanned Aerial Vehicles From Theory to Applications Special Session 3: From Data to Knowledge: Big Data applications and solutions.