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Sample records for atr kartini berdasarkan

  1. The current status of Kartini research reactor

    Energy Technology Data Exchange (ETDEWEB)

    Tri Wulan Tjiptono; Syarip

    1998-10-01

    The Kartini reactor reached the first criticality on January 25, 1979. In the first three years, the reactor power is limited up to 50 kW thermal power and on July 1, 1982 has been increased to 100 kW. It has been used as experiments facility by researcher of Atomic Energy National Agency and students of the Universities. Three beam tubes used as experiments facilities, the first, is used as a neutron source for H{sub 2}O-Natural Uranium Subcritical Assembly, the second, is developed for neutron radiography facility and the third, is used for gamma radiography facility. The other facilities are rotary rack and two pneumatic transfer systems, one for delayed neutron counting system and the other for the new Neutron Activation Analysis (NAA) facility. The rotary rack used for isotope production for NAA purpose (for long time irradiation), the delayed neutron counting system used for analysis the Uranium contents of the ores and the new NAA is provided for short live elements analysis. In the last three years the Reactor Division has a joint use program with the Nuclear Component and Engineering Center in research reactor instrumentation and control development. (author)

  2. Operation experiences of the Kartini reactor using Bandung Triga Mark II spent fuels

    International Nuclear Information System (INIS)

    The operating history and improvements of the Kartini research reactor are presented. The Kartini reactor is operated during office hours: 5 days a week and 6-7 hours a day, except in particular cases. For 15 years since 1979 the Kartini reactor has been operated using spent fuels and used core from the Bandung Triga Mark II. Since 1994, however the Kartini reactor has been operated using the 104 SS type of fuel elements. Several difficulties and anomalies were encountered during its operation. A brief explanation of the maintenance, quality control and quality assurance programme during its operation are also discussed. (orig.)

  3. Safety culture and quality management of Kartini research reactor

    International Nuclear Information System (INIS)

    The evaluation for assessing the safety culture and quality of safety management of Kartini research reactor is presented. The method is based on the concept of management control of safety (audit) as well as by using the developed method i.e. the questionnaires concerning areas of relevance which have to be answered with value statements. There are seven statements or qualifiers in answering the questions. Since such statements are vague, they are represented by fuzzy numbers. The weaknesses can be identified from the different areas contemplated. The evaluation result show that the quality of safety management of Kartini research reactor is globally rated as 'Average'. The operator behavior in the implementation of 'safety culture' concept is found as a weakness, therefore this area should be improved. (author)

  4. Safety culture and quality management of Kartini research reactor

    Energy Technology Data Exchange (ETDEWEB)

    Syarip [Yogyakarta Nuclear Research Centre, Yogyakarta (Indonesia); Hauptmanns, Ulrich [Department of Plant Design and Safety, Otto-Von-Guericke-University, Magdeburg (Germany)

    1999-10-01

    The evaluation for assessing the safety culture and quality of safety management of Kartini research reactor is presented. The method is based on the concept of management control of safety (audit) as well as by using the developed method i.e. the questionnaires concerning areas of relevance which have to be answered with value statements. There are seven statements or qualifiers in answering the questions. Since such statements are vague, they are represented by fuzzy numbers. The weaknesses can be identified from the different areas contemplated. The evaluation result show that the quality of safety management of Kartini research reactor is globally rated as 'Average'. The operator behavior in the implementation of 'safety culture' concept is found as a weakness, therefore this area should be improved. (author)

  5. Kartini Research Reactor prospective studies for neutron scattering application

    Energy Technology Data Exchange (ETDEWEB)

    Widarto [Yogyakarta Nuclear Research Center, BATAN (Indonesia)

    1999-10-01

    The Kartini Research Reactor (KRR) is located in Yogyakarta Nuclear Research Center, Yogyakarta - Indonesia. The reactor is operated for 100 kW thermal power used for research, experiments and training of nuclear technology. There are 4 beam ports and 1 column thermal are available at the reactor. Those beam ports have thermal neutron flux around 10{sup 7} n/cm{sup 2}s each other and used for sub critical assembly, neutron radiography studies and Neutron Activation Analysis (NAA). Design of neutron collimator has been done for piercing radial beam port and the calculation result of collimated neutron flux is around 10{sup 9} n/cm{sup 2}s. This paper describes experiment facilities and parameters of the Kartini research reactor, and further more the prospective studies for neutron scattering application. The purpose of this paper is to optimize in utilization of the beam ports facilities and enhance the manpower specialty. The special characteristic of the beam ports and preliminary studies, pre activities regarding with neutron scattering studies for KKR is presented. (author)

  6. The Calculation Of Total Radioactivity Of Kartini Reactor Fuel Element

    International Nuclear Information System (INIS)

    The total radioactivity of Kartini reactor fuel element has been calculated by using ORIGEN2. In this case, the total radioactivity is the sum of alpha, beta, and gamma radioactivity from activation products nuclides, actinide nuclides and fission products nuclides in the fuel element. The calculation was based on irradiation history of fuel in the reactor core. The fuel element no 3203 has location history at D, E, and F core zone. The result is expressed in graphics form of total radioactivity and photon radiations as function of irradiation time and decay time. It can be concluded that the Kartini reactor fuel element in zone D, E, and F has total radioactivity range from 10 Curie to 3000 Curie. This range is for radioactivity after decaying for 84 days and that after reactor shut down. This radioactivity is happened in the fuel element for every reactor operation and decayed until the fuel burn up reach 39.31 MWh. The total radioactivity emitted photon at the power of 0.02 Watt until 10 Watt

  7. The Expert System For Safety Assesment Of Kartini Reactor Operation And Maintenance

    International Nuclear Information System (INIS)

    An expert system for safety assessment of Kartini reactor operation and maintenance based on fuzzy logic method has been made. The expert system is developed from the Fuzzy Expert System Tools (FEST), i.e. by developing the knowledge base and data base files of Kartini research reactor system and operations with an inference engine based on FEST. The knowledge base is represented in the procedural knowledge as heuristic rules or generally known as rule-base in the from of If-then rule. The fuzzy inference process and the conclusion of the rule is done by FEST based on direct chaining method with interactive as well as non-interactive modes. The safety assessment of Kartini reactor based on this method gives more realistic value than the conventional method or binary logic

  8. Maximum core loading of Kartini Reactor at 250 kW of power level

    International Nuclear Information System (INIS)

    Maximum core loading of Kartini Reactor at 250 kW of power level. Reevaluation of the safety aspect of Kartini Reactor is currently being performed, for the purpose of increasing the nominal power from 100 to 250 kW. The results of the evaluations will be used to verify the feasibility of the reactor to operate at the proposed power level. One of the important safety parameters which needs to be reevaluated is related to the shutdown capability of the available control rods, which is normally indicated through the parameter of available Shudown Margin (SDM), which is a function of both power level and Core Loading. This paper presents the methodology and the result of determining the Maximum Core Loading of Kartini Reactor at power level of 250 kW. The result indicates that the maximum core loading of Kartini reactor, for 250 kW of Nominal Power is 82 fuel elements, associated with 3.8 $ of available core excess. It is concluded that the negative reactivity of the available control rods is still sufficient to compensate the amount of reactivity produced by the addition of 11 new fuel elements over the minimum requirement for operation at 250 kW of power level

  9. Root cause analysis of swelling problem in Kartini reactor

    International Nuclear Information System (INIS)

    Root cause analysis (RCA) is applied for the swelling problem in the Kartini reactor. The RCA result shows that probable root cause of swelling are as follows: It is probable that the seal on the cover plate in the service pool has deteriorated and allowed water to enter both the thermal column and the space between the aluminium reactor pool liner and the concrete. The water will also saturate the concrete and has the potential to corrode the steel reinforcement close to the surface of the concrete. It is believed that water leakage from the service pool has entered the area behind the aluminium pool liner and has saturated the concrete. It is believed that carbon steel reinforcement close to the inner surface of the reactor block has corroded. The expanding corrosion product (rust) has the forced layer of concrete covering the steel reinforcement and subsequently pushing the aluminium pool liner inwards, causing the swelling. There are two issues: the mechanism for the creation of the swellings or bulges dominated by Iron corrosion, and the potential for corrosion of aluminium dominated by the pH of water in contact with the aluminium. As the evidence for this condition were: the apparent corrosion of steel reinforcement behind aluminium liner and formation of Ca(CO3) on outside of concrete reactor block indicating water saturation of the concrete block. The condition is advancing and will most probably result in a loss of pool liner integrity, this may or may not result in a loss of pool water due to the concrete backing behind the pool liner. Based on the above analysis, the remedial actions that can be considered are as follows: The pool liner would be patched with a welded panel that would allow the features we have observed to keep growing in a harmless way. It is expected that they will reach a finite size as the iron is consumed by corrosion. The area behind the pool liner would be dried out, this should limit further growth of the bulges by improving the

  10. Design and Development of Data Acquisition System Process Parameters of Kartini Reactor

    International Nuclear Information System (INIS)

    Design and development of computer program for data acquisition system of process parameters of the Kartini reactor have been done. System was designed using industrial computer which equipped with electronic module PCL-812PG. The function of computer is to take parameter data of reactor process, processing the data and displaying on the numeric form and bar graphic. Electronics module PCL- 12PG was installed in one of computer slot, functions to convert from analog signal to digital, received digital status signal and produce digital output. The analog signal and digital status got from logarithmic power channel, linear power channel dan three control rod. Result of data acquisition is merged in the form of ASCII characters block, send to the master computer serially with communications protocols RS-232. Computer program which has been developed was tested and used for monitoring Kartini reactor operation and give good performance result. (author)

  11. Evaluation on Operation and Safety Function of the Kartini Reactor Ventilation System

    International Nuclear Information System (INIS)

    In nuclear reactor, for research purposes or power plant, shall be provided with VAC and air cleaning system for safety reason. Kartini Reactor in Yogyakarta is also equipped with Ventilation System, which have been operating until now as supporting system for the reactor operation. It was designed to provide air exchange rate up to 6 times/hour, and equipped with Filtration System for air cleaning of the exhaust air before released through the stack to atmosphere. Based on visual survey, measurement, calculation and assumption, also modification on the construction of ventilation system, such as the exhaust blower was designed prior for three installations in this time has been used for reactor installation only so the blower becomes over capacity. Reevaluation and in accordance with the theory of safety for nuclear installation which is also referred to some installations at Serpong, therefore the Kartini Reactor Ventilation should be more improved, so that some alternative recommendations are given. (author)

  12. Ageing investigation and upgrading of components/systems of Kartini research reactor

    International Nuclear Information System (INIS)

    Kartini research reactor has been operated in good condition and has demonstrated successful operation for the past 18 years, utilized for: reactor kinetic and control studies, instrumentation tests, neutronic and thermohydraulic studies, routine neutron activation analysis, reactor safety studies, training for research reactor operators and supervisors, and reactor physics experiments. Several components of Kartini reactor use components from the abandoned IRT-2000 Project at Serpong and from Bandung Reactor Centre such as: reactor tank, reactor core, heat exchanger, motor blower for ventilation system, fuel elements, etc. To maintain a good operating performance and also for aging investigation purposes, the component failure data collection has been done. The method used is based on the Manual on Reliability Data Collection For Research Reactor PSAs, IAEA TECDOC 636, and analyzed by using Data Entry System (DES) computer code. Analysis result shows that the components/systems failure rate of Kartini reactor is around 1,5.10-4 up to 2,8.10-4 per hour, these values are within the ranges of the values indicated in IAEA TECDOC 478. Whereas from the analysis of irradiation history shows that the neutron fluence of fuel element with highest burn-up (2,05 gram U-235 in average) is around 1.04.1016 n Cm-2 and this value is still far below its limiting value. Some reactor components/systems have been replaced and upgraded such as heat exchanger, instrumentation and control system (ICS), etc. The new reactor ICS was installed in 1994 which is designed as a distributed structure by using microprocessor based systems and bus system technology. The characteristic and operating performance of the new reactor ICS, as well as the operation history and improvement of the Kartini research reactor is presented. (J.P.N.)

  13. Ageing investigation and upgrading of components/systems of Kartini research reactor

    Energy Technology Data Exchange (ETDEWEB)

    Syarip; Widi Setiawan [Yogyakarta Nuclear Research Centre, Yogyakarta (Indonesia)

    1998-10-01

    Kartini research reactor has been operated in good condition and has demonstrated successful operation for the past 18 years, utilized for: reactor kinetic and control studies, instrumentation tests, neutronic and thermohydraulic studies, routine neutron activation analysis, reactor safety studies, training for research reactor operators and supervisors, and reactor physics experiments. Several components of Kartini reactor use components from the abandoned IRT-2000 Project at Serpong and from Bandung Reactor Centre such as: reactor tank, reactor core, heat exchanger, motor blower for ventilation system, fuel elements, etc. To maintain a good operating performance and also for aging investigation purposes, the component failure data collection has been done. The method used is based on the Manual on Reliability Data Collection For Research Reactor PSAs, IAEA TECDOC 636, and analyzed by using Data Entry System (DES) computer code. Analysis result shows that the components/systems failure rate of Kartini reactor is around 1,5.10{sup -4} up to 2,8.10{sup -4} per hour, these values are within the ranges of the values indicated in IAEA TECDOC 478. Whereas from the analysis of irradiation history shows that the neutron fluence of fuel element with highest burn-up (2,05 gram U-235 in average) is around 1.04.10{sup 16} n Cm{sup -2} and this value is still far below its limiting value. Some reactor components/systems have been replaced and upgraded such as heat exchanger, instrumentation and control system (ICS), etc. The new reactor ICS was installed in 1994 which is designed as a distributed structure by using microprocessor based systems and bus system technology. The characteristic and operating performance of the new reactor ICS, as well as the operation history and improvement of the Kartini research reactor is presented. (J.P.N.)

  14. Modification and Continue Monitoring of Kartini Reactor Tank Liner for Long Term Safe Operation

    International Nuclear Information System (INIS)

    This paper discusses an experience on modification of bulk shielding facility (BSF) and monitoring of the Kartini reactor tank liner through in-service inspection (ISI) for long term safe operation. The objective of BSF modification is to prevent future water penetration from BSF to both the thermalizing column and space between the aluminium reactor tank liner and the concrete. Modification of BSF needs to be conducted because leakage from the BSF has entered to the area behind the aluminium tank liner and has saturated the concrete that has potential to corrode the steel reinforcement bar, and subsequently pushing the aluminium bottom tank and causing the swelling. The three swelling on the bottom tank have been continued monitoring through ISI regularly since 2001 up to now to observe and measure the three swellings profile. Result of swellings profile measurement indicated that swelling had grown slowly in size and became relatively stable. Careful analysis and assessment of the root causes of the swelling indicated that swelling do not present a threat to future safe operation of the reactor and Kartini reactor is considered to be in good condition. As an outcome of modification and continue monitoring, Kartini Reactor in Yogyakarta has been already obtained extended operation license for the third period from Nuclear Energy Regulatory Agency of Indonesia (BAPETEN) up to 2020

  15. Atlantic Test Range (ATR)

    Data.gov (United States)

    Federal Laboratory Consortium — ATR controls fully-instrumented and integrated test ranges that provide full-service support for cradle-to-grave testing. Airspace and surface target areas are used...

  16. ATR neutron spectral characterization

    International Nuclear Information System (INIS)

    The Advanced Test Reactor (ATR) at INEL provides intense neutron fields for irradiation-effects testing of reactor material samples, for production of radionuclides used in industrial and medical applications, and for scientific research. Characterization of the neutron environments in the irradiation locations of the ATR has been done by means of neutronics calculations and by means of neutron dosimetry based on the use of neutron activation monitors that are placed in the various irradiation locations. The primary purpose of this report is to present the results of an extensive characterization of several ATR irradiation locations based on neutron dosimetry measurements and on least-squares-adjustment analyses that utilize both neutron dosimetry measurements and neutronics calculations. This report builds upon the previous publications, especially the reference 4 paper. Section 2 provides a brief description of the ATR and it tabulates neutron spectral information for typical irradiation locations, as derived from the more historical neutron dosimetry measurements. Relevant details that pertain to the multigroup neutron spectral characterization are covered in section 3. This discussion includes a presentation on the dosimeter irradiation and analyses and a development of the least-squares adjustment methodology, along with a summary of the results of these analyses. Spectrum-averaged cross sections for neutron monitoring and for displacement-damage prediction in Fe, Cr, and Ni are given in section 4. In addition, section4 includes estimates of damage generation rates for these materials in selected ATR irradiation locations. In section 5, the authors present a brief discussion of the most significant conclusions of this work and comment on its relevance to the present ATR core configuration. Finally, detailed numerical and graphical results for the spectrum-characterization analyses in each irradiation location are provided in the Appendix

  17. Safety Management and Safety Culture Self Assessment of Kartini Research Reactor

    International Nuclear Information System (INIS)

    The self-assessment of safety culture and safety management status of Kartini research reactor is a step to foster safety culture and management by identifying good practices and areas for improvement, and also to improve reactor safety in a whole. The method used in this assessment is based on questionnaires provided by the Forum for Nuclear Cooperation in Asia (FNCA), then reviewed by experts. Based on the assessment and evaluation results, it can be concluded that there were several good practices in maintaining the safety status of Kartini reactor such as: reactor operators and radiation protection workers were aware and knowledgeable of the safety standards and policies that apply to their operation, readily accept constructive criticism from their management and from the inspectors of regulatory body that address safety performance. As a proof, for the last four years the number of inspection/audit findings from Regulatory Body (BAPETEN) tended to decrease while the reactor utilization and its operating hour increased. On the other hands there were also some comments and recommendations for improvement of reactor safety culture, such as that there should be more frequent open dialogues between employees and managers, to grow and attain a mutual support to achieve safety goals. (author)

  18. Study on the effect of moderator density reactivity for Kartini reactor

    International Nuclear Information System (INIS)

    One of important characteristics of water-cooled reactors is the change of reactivity due to change in the density of coolant or moderator. This parameter generally has negative value and it has significant role in preventing the excursion of power during operation. Many thermal-hydraulic codes for nuclear reactors require this parameter as the input to account for reactivity feedback due to increase in moderator voids and the subsequent decrease in moderator density during operation. Kartini reactor is cooled and moderated by water, therefore, it is essential to study the effect of the change in moderator density as well as to determine the value of void or moderator density reactivity coefficient in order to characterize its behavior resulting from the presence of vapor or change of moderator density during operation. Analysis by MCNP code shows that the reactivity of core is decreasing with the decrease in moderator density. The analysis estimates the void or moderator density reactivity coefficient for Kartini Reactor to be -2.17×10-4 Δρ/%void. (author)

  19. Ageing Management Programme: An Experience of In-Service Inspection of the Kartini Heat Exchanger

    International Nuclear Information System (INIS)

    This paper discusses an experience on ISI of the Kartini reactor heat exchanger, as part of the implementation of an ageing management programme. Kartini reactor is located in Yogyakarta, Indonesia. The heat exchanger was constructed for 250 kW capacity. The type of heat exchanger is shell with tube recirculation. Tube material is stainless steel 304, and the shell and baffle plate materials are carbon steel. The heat exchanger has 72 tubes, its outer and inner diameters respectively are 19 and 16 mm, and tube thickness is 1.5 mm. The aim of ISI was to obtain and evaluate the heat exchanger’s condition including the detection of any possible local tube thinning, pitting corrosion or gradual thinning, and determine whether any degradation or deterioration of the heat exchanger could have a significant impact to safety. The heat exchanger was inspected utilizing eddy current equipment in 2003 and 2006. Inspection results in 2003 determined that 12 heat exchanger tubes have a thinning degradation level ranging from 10% up to 60% of the outer diameter due to pitting corrosion. Deterioration of baffle plates has been linked to general corrosion attack. Inspection results in 2006 showed a consistent thinning degradation level with the previous inspection in 2003. So far heat exchanger performance is still satisfactory, as defined by the transfer of primary heat for a 2°C difference between inlet and outlet as required. (author)

  20. PUREX new substation ATR

    International Nuclear Information System (INIS)

    This document is the acceptance test report (ATR) for the New PUREX Main and Minisubstations. It covers the factory and vendor acceptance and commissioning test reports. Reports are presented for the Main 5 kV substation building, the building fire system, switchgear, and vacuum breaker; the minisubstation control building and switch gear; commissioning test; electrical system and loads inspection; electrical utilities transformer and cable; and relay setting changes based on operational experience

  1. Application Of WIMS Code To Calculation Kartini Reactor Parameters By Pin-Cell And Cluster Method

    International Nuclear Information System (INIS)

    Analysis UZrH fuel element parameters calculation in Kartini Reactor by WIMS Code has been done. The analysis is done by pin cell and cluster method. The pin cell method is done as a function percent burn-up and by 8 group 3 region analysis and cluster method by 8 group 12 region analysis. From analysis and calculation resulted K∼ = 1.3687 by pin cell method and K∼ = 1.3162 by cluster method and so deviation is 3.83%. By pin cell analysis as a function percent burn-up at the percent burn-up greater than 59.50%, the multiplication factor is less than one (k∼ < 1) it is mean that the fuel element reactivity is negative

  2. Design of Computerized in Core Fuel Management System of Kartini Reactor

    International Nuclear Information System (INIS)

    The program organization for managing Kartini reactor fuel elements has been designed. This program organization work to process on-line operationdata-base and core configuration data-base to produce data-base for in-corefuer management. The in-core fuel management data-base consist of irradiationhistory card, radionuclides inventory and radiation dose for each fuelelement. The computation in this process based on the ORIGEN2, TRIGAP codesand some in-house developed codes that perform matching between output dataof many codes to output data of other code. This program organization worksunder control of a program manager by following the scheduled time table. Thedesign gives a description of the first step development of the in-core fuelmanagement that will be implemented in the internet web server. (author)

  3. The Reactor Power Distribution Calculation as Kartini Core ConfigurationFunctions

    International Nuclear Information System (INIS)

    Reactor power distribution as Kartini core configuration function for 250kW power has been done. According to the Kartini upgrading of reactor powerfrom 100 kW to 250 kW, research for determining the most appropriate coreconfiguration and reactor safety requirement must be done. For this purpose,using the TRIGAP code the power distribution calculations has been done. Thecore configuration to used in this calculation based on the last coreconfiguration then it is added by one by one new fuel element until theeffective multiplication greater than one and it achieved by adding 4 newfuel element minimal. After that the there are 6 configuration will be usedas trial and error for core configuration in reactor power distributioncalculation for determining the most appropriate configuration for 250 kWpower, and the safety requirement and the neutron flux as desired. Based onthe calculation shown that the core configuration with 4 new fuel elementsplaced at ring B (first configuration model) or F (6th core configurationmodel), are the most appropriate configuration. The two differences are asfollows the first has reactivity adding 0.577 dollar and the second one 0.365dollar. According to the neutron flux on the irradiation facility the secondconfiguration better than the first where 3.9379 x 1011 n/cm2s (fast) and5.7795 n/cm2s (thermal) and 3.4926 x 1012 n/cm2s (fast) and 2.0486n/cm2s (thermal) respectively. According to the power reactor up-grading isto improve the neutron flux at the irradiation facility, the most appropriatecore configuration is the 6th configuration where the 4 new fuel elementsare placed on ring F. (author)

  4. The Computation And Analysis Of The Correction Factor Of Heat Transfer Coefficient For The Kartini Reactor S Heat Exchanger

    International Nuclear Information System (INIS)

    The computation and analysis of the heat transfer coefficient correction factor the shell and tube type of the Kartini reactor's heat exchanger (HE) has been carried out. The computation of the correction factor was done by measuring of the actual dimension of HE. As known that the shell and tube type of the Kartini reactor's has been opera-ted for more than 15 years. Due to the scraping and rusting occur at the buffle, the total heat transfer coefficient correction factor Ft was decrease. At the later computation, it is found that it's value is 0,4669 or differ of 0,1331 compared to the prediction standard value. So far, if the rusting and scraping of the secondary water coolant to the buffle is linear to the earlier HE's operation time, it is predicted that the function of the buffle will crisis approximately in the year of 2002/2003 or 7,5 years again

  5. PENENTUAN DAERAH RAWAN GIZI BERDASARKAN ANALISIS SPATIAL

    Directory of Open Access Journals (Sweden)

    Noviati Fuada

    2012-11-01

    Full Text Available Latar Belakang : Riset Kesehatan Dasar telah dilakukan di Indonesia (RISKESDAS 2007. Riset telah mengumpulkan data-data yang terdiri dari data kesehatan yang menggambarkan status gizi anak di bawah lima (antrophometri data di seluruh wilayah Indonesia. Kenyataanya masih sedikit analisis dengan menggunakan metode GIS, oleh karena itu artikel ini akan dikaji dengan metode spasial. Kajian ini diharapkan dapat memberikan informasi faktual, yang dapat mendukung kebijakan daerah. Tujuan: Mengidentifikasi daerah kabupaten/provinsi rawan status gizi anak balita, Metode: Analisa GIS denganmenggunakan metode spasial (pengelompokan data dan overlay dengan cara union. Data RISKESDAS 2007. Hasil: Wilayah tingkat tinggi potensi rawan gizi bermasalah (bersumber overlay antara peta sebaran status gizi balita dengan peta sebaran KK miskin  adalah; Kota Tasikmalaya, Kab. Tasikmalaya, Cianjur, Garut, Ciamis, Bandung, Subang dan Majalengka. Wilayah tingkat tinggi berpotensi terkena infeksi penyakit (berdasarkan peta sebaran resiko Infeksi Penyakit dan pemanfaatan posyandu adalah: Kabupaten Purwakarta, Karawang, Bekasi, Bogor, Sukabumi, Tasikmalaya, Kota Tasikmalaya, Bekasi dan Bogor. Wilayah berpotensi rawan gizi kategori tinggi (bersumber pada 4 faktor/peta sebaran meliputi, Kabupaten Cianjur, Garut, Tasikmalaya dan Kota Tasikmalaya. Kasus Gizi bermasalah berdasarkan 3 indeks gabungan menyebar di seluruh wilayah Provinsi Jawa Barat. Wilayah kasus gizi bermasalah kategori tinggi, dan kategori sedang, sebagian besar  terjadi di wilayah Kabupaten. Baik kategori sedang maupun tinggi merupakan wilayah yang berdampingan. Gambaran ini mengarah pada fakta bahwa  masalah gizi cenderung merupakan masalah epidemiologi. Kesimpulan: Terdapat empat wilayah kabupaten status gizi yang paling serius dalam kategori tinggi meliputi, Kabupaten Cianjur, Garut, Tasikmalaya dan Kota Tasikmalaya.  Kata kunci: analisis spasial, status gizi, posyandu, rawan gizi 

  6. HEATR project: ATR algorithm parallelization

    Science.gov (United States)

    Deardorf, Catherine E.

    1998-09-01

    High Performance Computing (HPC) Embedded Application for Target Recognition (HEATR) is a project funded by the High Performance Computing Modernization Office through the Common HPC Software Support Initiative (CHSSI). The goal of CHSSI is to produce portable, parallel, multi-purpose, freely distributable, support software to exploit emerging parallel computing technologies and enable application of scalable HPC's for various critical DoD applications. Specifically, the CHSSI goal for HEATR is to provide portable, parallel versions of several existing ATR detection and classification algorithms to the ATR-user community to achieve near real-time capability. The HEATR project will create parallel versions of existing automatic target recognition (ATR) detection and classification algorithms and generate reusable code that will support porting and software development process for ATR HPC software. The HEATR Team has selected detection/classification algorithms from both the model- based and training-based (template-based) arena in order to consider the parallelization requirements for detection/classification algorithms across ATR technology. This would allow the Team to assess the impact that parallelization would have on detection/classification performance across ATR technology. A field demo is included in this project. Finally, any parallel tools produced to support the project will be refined and returned to the ATR user community along with the parallel ATR algorithms. This paper will review: (1) HPCMP structure as it relates to HEATR, (2) Overall structure of the HEATR project, (3) Preliminary results for the first algorithm Alpha Test, (4) CHSSI requirements for HEATR, and (5) Project management issues and lessons learned.

  7. Analysis and measurement of Kartini reactor parameters for application of K0-NAA method

    International Nuclear Information System (INIS)

    The k0-NAA method is an analysis method that widely used by many of the advantages. In the application of k0-NAA method needed values of reactor parameters (f and α), then the purpose of the research would be conducted measurement parameter values f and a. in the Lazy Susan Kartini reactor facilities. The methods used include Cd-ratio and triple bare methods. The parameter value has been measured in three channels in the irradiation facilities Lazy Susan. Differences of measurement results obtained parameter values are significant in each channel irradiation, the value off ranged from 13,713 to 22,128 and the value of a. ranged from -0,060 to 0,068. The results of measurements for the f and α with the Cd-ratio method, providing more stable value than the triple bare method. The value of f and α obtained can be used a database for the application of k0-NAA method for sample analysis in the laboratory NAA - CAST. (author)

  8. Application of fuzzy set theory for safety culture and safety management assessment of Kartini research reactor

    International Nuclear Information System (INIS)

    The safety culture status of nuclear power plant is usually assessed through interview and/or discussions with personnel and management in plant, and an assessment of the pertinent documentation. The approach for safety culture assessment described in IAEA Safety Series, make uses of a questionnaire composed of questions which require 'Yes' or 'No' as an answer. Hence, it is basically a check-list approach which is quite common for safety assessments in industry. Such a procedure ignores the fact that the expert answering the question usually has knowledge which goes far beyond a mere binary answer. Additionally, many situations cannot readily be described in such restricted terms. Therefore, it was developed a checklist consisting of questions which are formulated such that they require more than a simple 'yes' or 'no' as an answer. This allows one to exploit the expert knowledge of the analyst appropriately by asking him to qualify the degree of compliance of each of the topics examined. The method presented has proved useful in assessing the safety culture and quality of safety management of the research reactor. The safety culture status and the quality of safety management of Kartini research reactor is rated as 'average'. The method is also flexible and allows one to add questions to existing areas or to introduce new areas covering related topics

  9. Current status, research progress and future plan of Kartini research reactor

    Energy Technology Data Exchange (ETDEWEB)

    Sardjono, Y.; Syarip; Tjiptono, T.W. [Yogyakarta Nuclear Research Center, Batan (Indonesia)

    1999-10-01

    The current status, research progress and future plan of the Kartini Research Reactor (KRR) is presented. The measurements of axial burn-up distributions for each fuel element by gamma scanning techniques, core axial power distribution display, fuel management for safeguards purpose as well as some research progress activities i.e.; utilization of beamport for: neutron radiography, application neutron activation analysis and history record of KRR power operations is also presented. The KRR is 100 kW pool water reactor type which uses natural circulation and provided by: five beamports in which one of them already coupled with natural uranium subcritical assembly, two thermalizing columns in which one of them is prepared for developing Boron Neutron Capture Therapy (BNCT), two rabbit systems utilized for special analysis uranium ore by delayed neutron counting techniques, one center timbre and 40 irradiation rack (lazy susan) for neutron activation analysis. The KRR was constructed as a second research reactor in Indonesia with special purpose for training and education, high safety margin with involve in high negative temperature coefficient which achieved its first criticality on January 25, 1979. The maximum power level on first criticality is 50 kW and since August 1981 up to now is operating 100 kW. Base on the KRR design limit, it is planned to increase the power level up to 250 kW in the future plan. The preliminary activities such as Non Destructive Testing (NDT) for some reactor components especially water tank and thermal column should be done before decided to increase power level. (author)

  10. Current status, research progress and future plan of Kartini research reactor

    International Nuclear Information System (INIS)

    The current status, research progress and future plan of the Kartini Research Reactor (KRR) is presented. The measurements of axial burn-up distributions for each fuel element by gamma scanning techniques, core axial power distribution display, fuel management for safeguards purpose as well as some research progress activities i.e.; utilization of beamport for: neutron radiography, application neutron activation analysis and history record of KRR power operations is also presented. The KRR is 100 kW pool water reactor type which uses natural circulation and provided by: five beamports in which one of them already coupled with natural uranium subcritical assembly, two thermalizing columns in which one of them is prepared for developing Boron Neutron Capture Therapy (BNCT), two rabbit systems utilized for special analysis uranium ore by delayed neutron counting techniques, one center timbre and 40 irradiation rack (lazy susan) for neutron activation analysis. The KRR was constructed as a second research reactor in Indonesia with special purpose for training and education, high safety margin with involve in high negative temperature coefficient which achieved its first criticality on January 25, 1979. The maximum power level on first criticality is 50 kW and since August 1981 up to now is operating 100 kW. Base on the KRR design limit, it is planned to increase the power level up to 250 kW in the future plan. The preliminary activities such as Non Destructive Testing (NDT) for some reactor components especially water tank and thermal column should be done before decided to increase power level. (author)

  11. Comprehensive in-service inspection of Kartini reactor tank liner and fitness for continued operation

    International Nuclear Information System (INIS)

    Full text: For safe operation of nuclear reactors, it is mandatory to examine the reactor components periodically, and this examination which is carried out during the service life of the component is called as in-service inspection. Kartini reactor has been in operation since 1979, and its operation license will end in November 2005, and it is expecting to have the operation continue for another ten to fifteen years. Therefore, it is essential to assure the safety aspect of the reactor, and a comprehensive assessment is thus required. The preliminary comprehensive in-service inspection of Kartini reactor core and tank liner by using Non-Destructive Testing (NDT) methods to maintain its safe operation, have been done. The type of NDT used were : visual examination using underwater camera and magnifier, hardness test using an Equotip D indentor, thickness test using ultrasonic probe, replication survey using dental putty, and dye penetrant test. The reactor core was emptied of its fuels and control rods, then the reactor pool tank is drained of water to a level of 0.5 m above core grid. Kartini reactor tank liner is made of aluminium material from abandoned IRT-2000 reactor tank, where the IRT-2000 research reactor project was abandoned since 1964. This aluminium tank wall was chemically analyzed and found to be consistent with Aluminium Association AA 1050 (99.5 % aluminium). A detailed visual inspection consisted of both direct visual inspection with the aid of a magnifier, and video examination of the core / reflector region of the tank using an underwater camera. The visual examination showed that the surface of reactor core and tank liner was in good condition and consistent with other reactors manufactured from the same material and length of service. The surface was coated with a light hydrated oxide consistent with the service environment. A hardness survey using an Equotip D indentor was conducted and the results indicated that the tank was in the annealed

  12. PROFIL RESILIENSI PENDIDIK BERDASARKAN RESILIENCE QUETIENT TEST

    Directory of Open Access Journals (Sweden)

    Prihastuti Prihastuti

    2013-01-01

    Full Text Available Penelitian ini bertujuan untuk memperoleh gambaran umum profile resiliensi pendidik Fakultas Psikologi Unair mela-lui Resilience Quotient Test (RQ. Instrumen yang digunakan adalah Resilience Quotient Test, yang terdiri 56 item. Resilience Quotient Test memuat 7 faktor, yaitu: emotional regulation, impulse control, emphati, optimism, causal analysis, self-efficacy dan reaching-out. Analisis profile resiliensi dilakukan berdasarkan perbandingan nilai rata-rata dari masing-masing faktor dengan nilai acuan yang sudah ditentukan dalam Resilience Quotient Test. Hasil penelitian menunjukkan 2 faktor berada pada kategori di atas rata-rata (impulse control dan optimism, 3 faktor berada pada kategori rata-rata (empathy, causal analysis dan reaching-out dan 2 faktor berada pada kategori di bawah rata-rata (emotional regulation dan self-efficacy. Dua faktor yang berada pada kategori di atas rata-rata, yaitu impulse control dan optimism belum menunjukkan hasil yang mantap karena tidak didukung oleh faktor lainnya yang berada pada system belief yang sama, yaitu emotional regulation dan self-efficacy. Oleh karena itu, impulse control yang berlawanan dengan emotional regulation serta optimism yang berlawanan dengan self-efficacy perlu dikaji lebih dalam. Kata kunci: profile resiliensi pendidik ______________________________________________________________ EDUCATORS’ RESILIENCE PROFILE BASED ON THE RESILIENCE QUOTIENT TEST Abstract This research aims to obtain an overview of profile resi-lience educators of the Faculty of Psychology Unair through the Resilience Quotient Test (RQ. The instrument used was the Resilience Quotient Test, which comprised 56 items. The test of the Resilience Quotient included seven factors, namely emotional regulation, impulse control, empathy, optimism, cau-sal analysis, self-efficacy and Reaching-out. The analysis of pro-file resilience was based on comparison of the average value of each factor with a predetermined reference

  13. Modelling collimator of radial beam port Kartini reactor for boron neutron capture therapy

    International Nuclear Information System (INIS)

    One of the cancer therapy methods is BNCT (Boron Neutron Capture Therapy). BNCT utilizes neutron nature by 10B deposited on cancer cells. The superiority of BNCT compared to the radiation therapy is the high level of selectivity since its level is within cell. This study was carried out on collimator modelling in radial beam port of reactor Kartini for BNCT. The modelling was conducted by simulation using software of Monte Carlo N-Particle version 5 (MCNP 5). MCNP5 is a package of the programs for both simulating and calculating the problem of particle transport by following the life cycle of a neutron since its birth from fission reaction, transport on materials, until eventually lost due to the absorption reaction or out from the system. The collimator modelling used materials which varied in size in order to generate the value of each of the parameters in accordance with the recommendation of the IAEA, the epithermal neutron flux (ϕepi) > 1.0 x 109n.cm-2s-1, the ratio between the neutron dose rate fast and epithermal neutron flux (Df/ϕepi) < 2.0 x 10-13 Gy.cm2.n-1, the ratio of gamma dose rate and epithermal neutron flux (Dγ/ϕepi) < 2.0 X10-13 Gy.cm2.n-1, the ratio between the thermal and epithermal neutron flux (ϕTh/ϕepi)< 0.05 and the ratio between the current and flux of the epithermal neutron (J/ϕepi) > 0.7. Based on the results of the optimization of the modeling, the materials and sizes of the collimator construction obtained were 0.75 cm Ni as collimator wall, 22 cm Al as a moderator and 4.5 cm Bi as a gamma shield. The outputs of the radiation beam generated from collimator modeling of the radial beam port were ϕepi = 5.25 x 106 n.cm-2.s-1, Df/ϕepi = 1.17 x 10-13Gy.cm2.n-1, Dγ/ϕepi = 1.70 x 10-12 Gy.cm2.n-1, ϕTh/ϕepi = 1.51 and J/ϕepi = 0.731. Based on this study, the result of the beam radiation coming out of the radial beam port dis not fully meet the criteria recommended by IAEA so need to continue this study to get the criteria of IAEA

  14. ANALISIS CITRA PERMUKAAN THERMOCHROMIC LIQUID CRYSTAL BERDASARKAN NILAI STATISTIK HUE

    Directory of Open Access Journals (Sweden)

    Risti Suryantari

    2014-05-01

    Full Text Available Tujuan dari penelitian ini adalah untuk mengamati perbedaan citra pada permukaan Thermocromic Liquid Crystal (TLC R25C5W akibat perubahan temperatur. Metode yang digunakan untuk analisis adalah pengolahan citra berbasis morfologi matematika menggunakan perangkat lunak Matlab2013a. Citra asli yang diperoleh dalam bentuk RGB dikonversi menjadi HSV (hue, saturation, value, dengan mengambil komponen hue saja. Proses utama yang digunakan adalah opening dengan struktur elemen (SE line. Berdasarkan analisis visual pada citra akhir hasil pengolahan citra, tampak bahwa terdapat perbedaan setiap citra untuk berbagai temperatur berdasarkan tingkat kecerahannya. Secara kuantitatif perbedaan tersebut dapat dilihat dari nilai statistiknya. Nilai max dan mean citra hue semakin meningkat seiring dengan meningkatnya temperatur.

  15. Rancang Robot Ponyortie Benda Berdasarkan (16 Warna) Berbasis Mikrokontroler

    OpenAIRE

    Simorangkir, Lyri Martin

    2015-01-01

    Telah dirancang robot penyortir benda berbasis mikrokontroler ATMega8535.Robot ini berfungsi sebagai pemindah benda ringan berdasarkan warna secara otomatis. Secara keseluruhan sistem otomatis ini terdiri dari robot lengan, konveyor statis bidang datar sebagai tempat benda/obyek, dan masing-masing tempat untuk ke-16 warna yang akan disortir. Secara garis besar sistem ini terdiri dari 4 (empat) buah motor servo sebagai aktuator lengan, 1 (satu) buah motor servo sebagai penggerak konyeyor, DT-S...

  16. ANALISIS PELAYANAN KB MANDIRI WANITA USIA SUBUR BERDASARKAN STATUS EKONOMI

    OpenAIRE

    Selma Siahaan; Siti Isfandari; Rini Sasanti Handayani

    2013-01-01

    Latar belakang: Penggunaan metode keluarga berencana (KB) oleh Wanita Usia Subur (WUS) antara lain dipengaruhi oleh faktor sosial ekonomi. Maka, masalah biaya yang harus dibayar oleh WUS untuk memperoleh pelayanan KB perludi pahami guna keberhasilan program KB Nasional. Metode: Studi menggunakan data Riset Kesehatan Dasar (Riskesdas) 2010, bertujuan untuk mengetahui biaya pelayanan KB yang dibayar oleh perempuan usia 10–59 tahun (WUS) yang pernah kawin menurut metode KB berdasarkan status eko...

  17. MODEL KESESUAIAN APLIKASI UNTUK GOVERNMENT BERDASARKAN BUDAYA ORGANISASI

    Directory of Open Access Journals (Sweden)

    Sri Handayaningsih

    2013-04-01

    Full Text Available Pengembangan E-Government pada sebuah Pemda ditopang oleh empat pilar yaitu kebijakan, kerangka peraturan, manajemen perubahan dan kebutuhan masyarakat. Proses bisnis pada dinas di pemda dan kebutuhan masyarakat terhadap dinas, memunculkan aplikasi yang dapat membantu proses bisnis dalam memberikan layanan pada masyarakat dan manajemen dalam internal dinas. Dalam banyak kasus pengembangan aplikasi pada Pemda tidak berdasarkan pada hal-hal seperti  proses bisnis yang dijalankan di dinas, budaya organisasi dan kebutuhan masyarakat sebagai konsumen namun hanya berdasarkan pada kebutuhan personal dan pemberian dari pusat. Hal ini mengakibatkan aplikasi yang dibangun tidak dapat bertahan lama, tidak dapat membantu seluruh kegiatan bisnis utama dinas dan dijalankan tidak sesuai dengan budaya organisasi yang sedang berjalan saat ini di dinas tersebut. Aplikasi yang harus dibangun dan dijalankan adalah 70% untuk kegiatan pelayanan pada masyarakat dan 30% manajemen organisasi. Pembuatan model kesesuai aplikasi pada sebuah dinas berdasarkan pada budaya yang sedang berjalan di dinas. Budaya organisasi yang berjalan saat ini di pemerintah provinsi DIY adalah budaya clan. Dasar dari kesesuaian aplikasi yang berjalan di sebuah dinas adalah rencana strategis jangka menengah (tahun 2009 s.d 2014. Model akan diukur dengan key performance indicator menggunakan acuan pada COBIT 4.1. Harapannya model dapat digunakan pada dinas di Provinsi DIY

  18. KEKERABATAN TEMBAKAU MADURA (Nicotiana tabacum L. BERDASARKAN KARAKTER MOLEKULAR

    Directory of Open Access Journals (Sweden)

    Budi Daryono

    2015-09-01

    Full Text Available Hasil eksplorasi tembakau Madura di empat kabupaten Madura didapatkan 22 genotip tembakau Madura. Untuk merakit varietas tembakau yang diinginkan terlebih dahulu dilakukan karakterisasi plasma nutfah yang ada.  Karakterisasi berdasarkan karakter molekular merupakan salah satu langkah awal sebelum melakukan perakitan varietas tembakau untuk mengetahui potensi tembakau yang akan digunakan sebagai bahan persilangan. Tujuan penelitian adalah untuk mengidentifikasi variabilitas genetik dan hubungan kekerabatan plasma nutfah tembakau Madura berdasarkan karakter molekular dengan analisis RAPD.     Hasil penelitian dapat disimpulkan bahwa : (1 berdasarkan penanda RAPD menggunakan primer OPB-8, OPC-11,OPF-10, OPA-2 dan OPC-15, dapat membedakan genotip yang mempunyai keragaman geneik besar dan genotip yang mempunyai jarak genetik yang kecil, (2 Hasil dendogram menunjukkan bahwa tembakau Madura terdiri dari dua kluster yaitu kluster A terdiri dari 15 genotip dan Kluster B terdiridari 7 genotip, sedangkan buka busaang dan prancak-95 terpisah dengan tembakau Madura yang lain dengan jarak genetik 0.44 dan 0.50 dan (3  Calon tetua terbaik untuk mendapatkan varietas yang diinginkan adalah buka busaang dan prancak-95.Kata kunci :hubungan kekerabatan, tembakau madura, RAPD

  19. Molecular Pathways: Targeting ATR in Cancer Therapy.

    Science.gov (United States)

    Karnitz, Larry M; Zou, Lee

    2015-11-01

    The human ATR gene encodes a kinase that is activated by DNA damage and replication stress as a central transducer of a checkpoint signaling pathway. Once activated, ATR phosphorylates multiple substrates, including the kinase Chk1, to regulate cell-cycle progression, replication fork stability, and DNA repair. These events promote cell survival during replication stress and in cells with DNA damage. Accordingly, there has been the tantalizing possibility that ATR inhibitors would be therapeutically useful, especially if they were more effective in tumor versus normal cells. Indeed, multiple studies have demonstrated that alterations that promote tumorigenesis, such as defects in the ATM-p53 pathway, constitutive oncogene activation, and acquisition of the alternative lengthening of telomeres pathway, render tumor cells sensitive to ATR inhibitor monotherapy and/or increase the synergy between ATR inhibitors and genotoxic chemotherapies. Now, nearly two decades after the discovery of ATR, two highly selective and potent ATR inhibitors, AZD6738 and VX-970, are in early-phase clinical trials either as monotherapies or paired with a variety of genotoxic chemotherapies. These trials will generate important insights into the effects of ATR inhibition in humans and the potential role of inhibiting this kinase in the treatment of human malignancies. PMID:26362996

  20. ATR promotes cilia signalling: links to developmental impacts

    OpenAIRE

    Stiff, Tom; Casar Tena, Teresa; O'Driscoll, Mark; Jeggo, Penny A.; Philipp, Melanie

    2016-01-01

    Mutations in ATR (ataxia telangiectasia and RAD3-related) cause Seckel syndrome (ATR-SS), a microcephalic primordial dwarfism disorder. Hitherto, the clinical manifestation of ATR deficiency has been attributed to its canonical role in DNA damage response signalling following replication fork stalling/collapse. Here, we show that ATR regulates cilia-dependent signalling in a manner that can be uncoupled from its function during replication. ATR-depleted or patient-derived ATR-SS cells form ci...

  1. Comprehensive In-Service Inspection of Kartini Reactor Tank Liner and Fitness for Continued Operation; Comprehensive In-Service Inspection of Kartini Reactor Tank Liner and Fitness for Continued Operation

    International Nuclear Information System (INIS)

    The preliminary comprehensive in-service inspection of the Kartini reactor core and tank liner by using non-destructive testing (NDT) methods to maintain its safe operation, have been done. The type of NDT used were visual examination using under-water camera and magnifier, replication survey using dental putty, hardness test using an Equotip-D indentor, thickness test using ultrasonic probe, and dye penetrant test. The visual examination showed that the surface of the reactor tank liner was in good condition. The hardness readings were considered to be consistent with the original condition of the tank. The slight increase in hardness at the reactor core area, and this is consistent with the neutron fluence experienced, i.e. ∼1015 n/cm2, where high fluence will cause higher increased hardness of the material. Results of an ultrasonic thickness survey showed that, on average, the tank thickness is between 5.0 mm and 6.5 mm, a low 2.1 mm thickness exists at the top of the tank liner in the belt area. But, because the area is a double layer aluminium plat, its decrement in thickness does not influence the reactor safety. The replica and dye penetrant test at the low thickness area and several suspected areas showed that there could be some defect from the original manufacture. Therefore, it can be concluded that the reactor tank liner is still feasible for continued safe operation. (author)

  2. Analysis and Determination of Temperature in the B Ring of the KartiniReactor Core Primary Cooling Water for 250 kW

    International Nuclear Information System (INIS)

    Analysis and determination of temperature in the B ring of primarycooling water in the Kartini reactor core for 250 kW of power level has beendone. The Instrumented Fuel Element (IFE) is used for measurement oftemperature with varying of power from 10 kW to 100 kW. Heat transfer ishappened from the fuel to the core primary cooling water as a function ofpower level. The calculation for determining of temperature of primarycooling water indicate that for operation 250 kW power level the temperatureof the core primary cooling water is Tp = 117.478 oC. (author)

  3. IDENTIFIKASI FITUR MELODI GENDING LANCARAN BERDASARKAN PENGENALAN POLA NOTASI

    Directory of Open Access Journals (Sweden)

    Arry Maulana Syarif

    2015-10-01

    Full Text Available Komposisi   gending   mempunyai   karakteristik   tersendiri. Terdapat kemiripan dalam rangkaian notasi di antara gending- gending. Penelitian ini bertujuan untuk mengidentifikasi pola notasi gending berdasarkan kemiripan antar-atributnya. Pasangan notasi ditentukan sebagai dasar analisis, dan algoritma apriori digunakan untuk menganalisis pasangan notasi dari sampel gending lancaran. Hasil yang dicapai dapat memetakan  dan  mengidentifikasi,  serta  memberikan  bobot nilai   ideal   untuk   merangkai   pasangan   notasi,   hingga merangkai gatra (1 gatra terdiri dari 4 notasi. Kata Kunci :pola notasi, apriori, gamelan, gending

  4. Vanadium irradiation at ATR - neutronics aspects

    Energy Technology Data Exchange (ETDEWEB)

    Gomes, I.C.; Smith, D.L. [Argonne National Laboratory, Chicago, IL (United States)

    1995-04-01

    Calculations were performed to estimate damage and transmutation rates in vanadium irradiated in the ATR (Advanced Test Reactor) located in Idaho. The main focuses of the study are to evaluate the transmutation of vanadium to chromium and to explore ways to design the irradiation experiment to avoid excessive transmutation. It was found that the A-hole of ATR produces damage rate of {approximately} 0.2%/dpa of vanadium to chromium. A thermal neutron filter can be incorporated into the design to reduce the vanadium-to-chromium transmutation rate to low levels. A filter 1-2 mm thick of gadolinium or hafnium can be used.

  5. Overview of the ATR power supplies

    International Nuclear Information System (INIS)

    The AGS to RHIC transfer line (ATR) transports a variety of beams from the Alternating Gradient Synchrotron (AGS) which gets its input from the Booster Synchrotron. In turn, the Booster receives input beams from either a Tandem Van de Graaff (heavy ions) or a Linac (protons). The AGS extracts beam bunches, up to a rate of 30 Hertz, to the ATR which feeds the Relativistic Heavy Ion Collider (RHIC) starting with the sextant test in January of 1997. The ATR is made up of the upgraded U line and the new W, X, and Y lines. A test in 1995 transported beam to the end of the W line. During normal operation, a pulsed switching magnet at the end of the W line will bend the beam into the X line or the Y line so that the two storage rings in RHIC are filled with counter rotating beams. The ATR line is comprised of 80 power supplies (PS's), 17 of which are upgraded AGS PS's. The remaining 63 PS's were newly purchased. These PS's range from bipolar 600 watt linear type trim magnet PS's to 1 Megawatt, thyristor, dipole PS's. Results of the commissioning runs will be presented, as well as descriptions of regulation, filtering, and analog and digital controls

  6. MIR-ATR sensor for process monitoring

    International Nuclear Information System (INIS)

    A mid-infrared attenuated total reflectance (MIR-ATR) sensor has been developed for chemical reaction monitoring. The optical setup of the compact and low-priced sensor consists of an IR emitter as light source, a zinc selenide (ZnSe) ATR prism as boundary to the process, and four thermopile detectors, each equipped with an optical bandpass filter. The practical applicability was tested during esterification of ethanol and formic acid to ethyl formate and water as a model reaction with subsequent distillation. For reference analysis, a Fourier transform mid-infrared (FT-MIR) spectrometer with diamond ATR module was applied. On-line measurements using the MIR-ATR sensor and the FT-MIR spectrometer were performed in a bypass loop. The sensor was calibrated by multiple linear regression in order to link the measured absorbance in the four optical channels to the analyte concentrations. The analytical potential of the MIR-ATR sensor was demonstrated by simultaneous real-time monitoring of all four chemical substances involved in the esterification and distillation process. The temporal courses of the sensor signals are in accordance with the concentration values achieved by the commercial FT-MIR spectrometer. The standard error of prediction for ethanol, formic acid, ethyl formate, and water were 0.38 mol L  −  1, 0.48 mol L  −  1, 0.38 mol L  −  1, and 1.12 mol L  −  1, respectively. A procedure based on MIR spectra is presented to simulate the response characteristics of the sensor if the transmission ranges of the filters are varied. Using this tool analyte specific bandpass filters for a particular chemical reaction can be identified. By exchanging the optical filters, the sensor can be adapted to a wide range of processes in the chemical, pharmaceutical, and beverage industries. (paper)

  7. ANALISIS PELAYANAN KB MANDIRI WANITA USIA SUBUR BERDASARKAN STATUS EKONOMI

    Directory of Open Access Journals (Sweden)

    Selma Siahaan

    2013-08-01

    Full Text Available Latar belakang: Penggunaan metode keluarga berencana (KB oleh Wanita Usia Subur (WUS antara lain dipengaruhi oleh faktor sosial ekonomi. Maka, masalah biaya yang harus dibayar oleh WUS untuk memperoleh pelayanan KB perludi pahami guna keberhasilan program KB Nasional. Metode: Studi menggunakan data Riset Kesehatan Dasar (Riskesdas 2010, bertujuan untuk mengetahui biaya pelayanan KB yang dibayar oleh perempuan usia 10–59 tahun (WUS yang pernah kawin menurut metode KB berdasarkan status ekonomi yang bersangkutan. Analisis data menggunakan analisis deskriptif, analisis bivariat dengan uji statistik chi-square. Hasil: Alat/obat KB disposible terbanyak yang digunakan WUS dari semua golongan status ekonomi adalah metode KB suntik, sedangkan kondom terbanyak digunakan oleh WUS dengan status ekonomi atas banyak. Sekitar 50% WUS dengan status ekonomi (SE rendah membayar biaya pelayanan KB berkisar Rp.10.000–Rp.15.000. Sementara itu WUS dengan SE atas terbanyak membayar sekitar > Rp. 20.000. Terdapat korelasi signifikan antara metode KB dengan biaya dan status ekonomi. Kesimpulan: Metode suntik masih merupakan metode pilihan bagi WUS di Indonesia dan pemilihan metode KB oleh WUS berhubungan dengan status ekonomi mereka. Oleh karena itu promosi kesehatan perlu terus digalakkan agar program KB pemerintah dengan IUD dapat lebih dikenal dan dapat diterima masyarakat. Di samping itu, diperlukan kebijakan khusus (bantuan kepada WUS dengan status ekonomi rendah sehingga IUD dapat diperoleh secara gratis atau setidaknya dengan biaya yang terjangkau.

  8. The Design Method for the ATR High Burnup MOX Fuel

    International Nuclear Information System (INIS)

    The Power Reactor and Nuclear Fuel Development Corporation (PNC) has developed the advanced thermal reactor (ATR). PNC is demonstrating MOX fuel utilization in a prototype of ATR, Fugen (165 MWe), in which 638 MOX fuel assemblies have been loaded without a failure since 1979. PNC is developing the high burn-up MOX fuel for the ATR to contribute to MOX fuels for thermal reactors. The statistical design evaluation method that included the MOX fuel rod performance evaluation code 'FEMAXI-ATR' was developed for the ATR high bum-up MOX fuel rod; it was verified that the integrity of the fuel could be maintained over the whole irradiation period

  9. TIPE-TIPE KALIMAT PASIF MURNI DALAM BAHASA JEPANG BERDASARKAN KATEGORI DAN PERAN SEMANTISNYA

    Directory of Open Access Journals (Sweden)

    Dedi Sutedi

    2013-10-01

    Full Text Available Kalimat pasif bahasa Jepang (BJ selama ini dipilah hanya berdasarkan fungsi dan kategori sintaksisnya sementara peran semantisnya kurang mendapat perhatian. Akibatnya, masih tersisa permasalahan seperti adanya beberapa kalimat pasif yang satu berterima sementara yang lain tidak, padahal fungsi dan kategori sintaksisnya sama. Penelitian ini mencoba menelaah kalimat pasif BJ dari segi fungsi, kategori, dan juga peran semantisnya, terutama kalimat pasif murni. Dari hasil analisis data diketahui bahwa berdasarkan fungsi dan kategorinya struktur pasif murni ada tiga macam struktur (A, B, C, sedangkan berdasarkan peran semantisnya dapat dipilah ke dalam delapan tipe (I sampai VIII. Subjek dan pelengkap pasif tipe I harus diisi oleh nomina bernyawa yang masing-masing berperan objective dan agentive; tipe II-V, tipe VII, dan VIII subjeknya diisi oleh nomina tidak bernyawa dan pelengkapnya diisi oleh nomina bernyawa yang keberterimaannya ditentukan oleh peran semantis dan tipe verbanya; dan dalam pasif tipe VI baik subjek maupun pelengkap diisi oleh nomina tidak bernyawa.

  10. ATR promotes cilia signalling: links to developmental impacts.

    Science.gov (United States)

    Stiff, Tom; Casar Tena, Teresa; O'Driscoll, Mark; Jeggo, Penny A; Philipp, Melanie

    2016-04-15

    Mutations inATR(ataxia telangiectasia and RAD3-related) cause Seckel syndrome (ATR-SS), a microcephalic primordial dwarfism disorder. Hitherto, the clinical manifestation of ATR deficiency has been attributed to its canonical role in DNA damage response signalling following replication fork stalling/collapse. Here, we show that ATR regulates cilia-dependent signalling in a manner that can be uncoupled from its function during replication. ATR-depleted or patient-derived ATR-SS cells form cilia of slightly reduced length but are dramatically impaired in cilia-dependent signalling functions, including growth factor and Sonic hedgehog signalling. To better understand the developmental impact of ATR loss of function, we also used zebrafish as a model. Zebrafish embryos depleted of Atr resembled ATR-SS morphology, showed a modest but statistically significant reduction in cilia length and other morphological features indicative of cilia dysfunction. Additionally, they displayed defects in left-right asymmetry including ambiguous expression ofsouthpaw, incorrectly looped hearts and randomized localization of internal organs including the pancreas, features typically conferred by cilia dysfunction. Our findings reveal a novel role for ATR in cilia signalling distinct from its canonical function during replication and strengthen emerging links between cilia function and development. PMID:26908596

  11. Delineasi Model Tentatif Sistem Geotermal dan Interpretasi Komprehensif Berdasarkan Analisis Geofisika, Geokimia, dan Geologi

    OpenAIRE

    Makhrani, Makhrani

    2013-01-01

    Telah didelineasi model tentatif sistem geothermal berdasarkan interpretasi komprehensif dari analisis geofisika, geokimia dan geologi yang dapat memperlihatkan lebih jauh tentang sistem geothermal di daerah penelitian. Analisis geofisika dilakukan untuk zonasi bawah permukaan (overburden, claycap dan reservoar) dan penentuan fasa fluida reservoar. Pola aliran hidrotermal bawah permukaan ditentukan dari analisis geofisika dan geokimia, didukung oleh analisis geologi. D...

  12. Perbandingan Konsumsi Lemak Berdasarkan Tingkat Keparahan Akne Vulgaris pada Siswa SMK Negeri 1 Kota Jambi

    OpenAIRE

    Nisa Sulistia; Nur Indrawati Lipoeto; Sri Lestari

    2015-01-01

    Abstrak Salah satu faktor pencetus akne vulgaris adalah diet tinggi lemak, terutama lemak jenuh. Tujuan penelitian ini adalah untuk mengetahui perbandingan konsumsi lemak berdasarkan tingkat keparahan akne vulgaris menurut kriteria Lehmann. Penelitian ini berupa studi analitik observasional dengan desain cross sectional melalui pemeriksaan statusdermatologikus menurut kriteria Lehmann dan pengambilan data konsumsi menggunakan FFQ (Food Frequency Questionnaire) pada 138 siswa kelas X dan XI SM...

  13. ATM and ATR:Sensing DNA damage

    Institute of Scientific and Technical Information of China (English)

    Jun Yang; Zheng-Ping Xu; Yun Huang; Hope E. Hamrick; Penelope J. Duerksen-Hughes; Ying-Nian Yu

    2004-01-01

    Cellular response to genotoxic stress is a very complex process, and it usually starts with the "sensing" or "detection" of the DNA damage, followed by a series of events that include signal transduction and activation of transcription factors. The activated transcription factors induce expressions of many genes which are involved in cellular functions such as DNA repair, cell cycle arrest, and cell death. There have been extensive studies from multiple disciplines exploring the mechanisms of cellular genotoxic responses, which have resulted in the identification of many cellular components involved in this process, including the mitogen-activated protein kinases (MAPKs) cascade. Although the initial activation of protein kinase cascade is not fully understood,human protein kinases ATM (ataxia-telangiectasia, mutated) and ATR (ATM and Rad3-related) are emerging as potential sensors of DNA damage. Current progresses in ATM/ATR research and related signaling pathways are discussed in this review, in an effort to facilitate a better understanding of genotoxic stress response.

  14. Towards universal enrichment nanocoating for IR-ATR waveguides.

    Science.gov (United States)

    Giammarco, James; Zdyrko, Bogdan; Petit, Laeticia; Musgraves, J David; Hu, Juejun; Agarwal, Anu; Kimerling, Lionel; Richardson, Kathleen; Luzinov, Igor

    2011-08-28

    Polymer multilayered nanocoating capable of concentrating various chemical substances at IR-ATR waveguide surfaces is described. The coating affinity to an analyte played a pivotal role in sensitivity enhancement of the IR-ATR measurements, since the unmodified waveguide did not show any analyte detection. PMID:21734984

  15. ATR FTIR Mapping of Leather Fiber Panels

    Science.gov (United States)

    Tondi, G.; Grünewald, T.; Petutschnigg, A.; Schnabel, T.

    2015-01-01

    Leather fiber panels are very promising materials for many applications, not only for the easy availability of the constituents but also for their outstanding fi re-retardant properties. These innovative composite panels can be an excellent material for building insulation, and in recent times, the interest of industries in this composite board has considerably arisen. For this reason the discrimination of the components in the leather fiber panels is becoming fundamental in order to ensure their homogeneous properties. A method to characterize the surface of these materials is then required. An ATR FTIR mapping system for the leather fiber panels has been performed with a Perkin-Elmer microscope coupled with a Frontier FTIR spectrometer. The system has successfully allowed transforming the optical image to a chemical one. This technique can be considered as a right tool for routine controls of the surface quality, especially when the leather shavings cannot be optically distinguished.

  16. HCLK2 is required for activity of the DNA damage response kinase ATR

    DEFF Research Database (Denmark)

    Rendtlew Danielsen, Jannie M; Larsen, Dorthe Helena; Schou, Kenneth Bødtker;

    2008-01-01

    ATR is a protein kinase that orchestrates the cellular response to replication problems and DNA damage. HCLK2 has previously been reported to stabilize ATR and Chk1. Here we provide evidence that human HCLK2 acts at an early step in the ATR signaling pathway and contributes to full-scale activation...... of ATR kinase activity. We show that HCLK2 forms a complex with ATR-ATRIP and the ATR activator TopBP1. We demonstrate that HCLK2-induced ATR kinase activity toward substrates requires TopBP1 and vice versa and provides evidence that HCLK2 facilitates efficient ATR-TopBP1 association. Consistent with...

  17. Proses Scaffolding Berdasarkan Diagnosis Kesulitan Siswa dalam Menyelesaikan Masalah Program Linear dengan Menggunakan Mapping Mathematic

    Directory of Open Access Journals (Sweden)

    Mustaqim Mustaqim

    2014-04-01

    Full Text Available Diagnosis kesulitan merupakan hal yang lebih penting bagi guru dalam mengajar. Dengan melakukan diagnosis, guru dapat mengetahui di bagian mana siswa mengalami kesulitan dan kemudian memberikan alternatif solusi tepat. Diagnosis bisa dilakukan dengan menggunakan mapping mathe-matic. Subjek penelitian ini adalah siswa kelas XI Program Agribisnis Ternak Ruminansia SMKN I Maesan Bondowoso sebanyak 6 siswa yang dipilih berdasarkan kesalahan dalam tes diagnosis dan kemampuan komunikasi. Data penelitian ini adalah hasil karya siswa, rekaman selama tes dan proses scaffolding, catatan penting, dan lembaran scaffolding. Akumulasi data dilakukan dengan uji teknik, wawancara, dan memberikan scaffolding. Pemberian scaffolding dalam penelitian ini seperti dalam strategi scaffolding yang dinyatakan oleh Anghilery. Aktivitas analisis data adalah langkah reduksi data, langkah penyajian data, dan langkah kesimpulan data. Berdasarkan hasil penelitian ditemukan bahwa pemberian scaffolding di bagian sulit yang dialami siswa dapat mengurangi/menghilangkan kesulitan siswa.Kata kunci: diagnosis, mapping mathematic, scaffolding

  18. Safety significance of ATR passive safety response attributes

    International Nuclear Information System (INIS)

    The Advanced Test Reactor (ATR) at the Idaho National Engineering Laboratory was designed with some passive safety response attributes which contribute to the safety of the facility. The three passive safety attributes being evaluated in the paper are: 1) In-core and in-vessel natural convection cooling, 2) a passive heat sink capability of the ATR primary coolant system (PCS) for the transfer of decay power from the uninsulated piping to the confinement, and 3) gravity feed of emergency coolant makeup. The safety significance of the ATR passive safety response attributes is that the reactor can passively respond to most transients, given a reactor scram, to provide adequate decay power removal and a significant time for operator action should the normal active heat removal systems and their backup systems both fail. The ATR Interim Level 1 Probabilistic Risk Assessment (PRA) models and results were used to evaluate the significance to ATR fuel damage frequency (or probability) of the above three passive response attributes. The results of the evaluation indicate that the first attribute is a major safety characteristic of the ATR. The second attribute has a noticeable but only minor safety significance. The third attribute has no significant influence on the ATR firewater injection system (emergency coolant system)

  19. Peningkatan Efektifitas Mesin Blowing Berdasarkan Evaluasi Overall Equipment Effectiveness dan FMEA pada Industri Manufaktur Plastik

    OpenAIRE

    Simorangkir, Hendra

    2015-01-01

    CV. Makmur Palas adalah perusahaan yang bergerak dibidang pembuatan kantong plastik asoy. Perusahaan ini melakukan kegiatan produksi dengan menggunakan beberapa mesin yaitu mesin pencincang, mesin boker, mesin mixer, mesin blowing, mesin potong, dan mesin pon. Kapasitas mesin yang paling kecil adalah mesin blowing. Berdasarkan data historis periode Januari - Desember 2014, mesin blowing mengalami downtime sebesar 885,15 jam dari total jam kerja tersedia 4.144 jam. Hal ini menyebabkan perusaha...

  20. PERBEDAAN AUDIT REPORT LAG BERDASARKAN KANTOR AKUNTAN PUBLIK, OPINI AUDIT DAN JENIS INDUSTRI

    OpenAIRE

    Lensa, Harini Antika Puspa

    2014-01-01

    Penelitian ini dilakukan pada perusahaan-perusahaan yang terdaftar di Bursa Efek Indonesia tahun 2010 sampai tahun 2012. Berdasarkan kriteria sampel penelitian diperoleh 362 perusahaan. Alat analisis yang digunakan adalah independent sample t-test dan one way anova. Hasil penelitian ini menunjukkan bahwa terdapat perbedaan audit report lag antara perusahaan yang diaudit oleh Kantor Akuntan Publik Big Four dengan audit report lag perusahaan yang diaudit oleh Kantor Akuntan Publik Non Big Fo...

  1. TIPE-TIPE KALIMAT PASIF MURNI DALAM BAHASA JEPANG BERDASARKAN KATEGORI DAN PERAN SEMANTISNYA

    OpenAIRE

    Dedi Sutedi

    2013-01-01

    Kalimat pasif bahasa Jepang (BJ) selama ini dipilah hanya berdasarkan fungsi dan kategori sintaksisnya sementara peran semantisnya kurang mendapat perhatian. Akibatnya, masih tersisa permasalahan seperti adanya beberapa kalimat pasif yang satu berterima sementara yang lain tidak, padahal fungsi dan kategori sintaksisnya sama. Penelitian ini mencoba menelaah kalimat pasif BJ dari segi fungsi, kategori, dan juga peran semantisnya, terutama kalimat pasif murni. Dari hasil analisis data diketahui...

  2. Perancangan Kursi Dan Meja Berdasarkan Antropometri Pada Sekolah Sd Siti Hajar

    OpenAIRE

    Siregar, Ramadhani

    2016-01-01

    Meja dan kursi merupakan fasilitas sekolah yang berpengaruh terhadap sikap duduk siswa saat belajar. Postur tubuh siswa akan bekerja secara alami jika menggunakan meja dan kursi yang ergonomis. Sebaliknya, jika meja dan kursi tidak ergonomis maka akan menimbulkan ketidaknyamanan sehingga menyebabkan keluhan musculoskeletal pada siswa. Berdasarkan pengamatan di Sekolah Dasar Siti Hajar, meja dan kursi yang digunakan memiliki ukuran yang sama mulai dari kelas I sampai dengan kelas VI, sedan...

  3. PEMODELAN STRUKTUR BAWAH PERMUKAAN DAERAH SUMBER AIR PANAS SONGGORITI KOTA BATU BERDASARKAN DATA GEOMAGNETIK

    Directory of Open Access Journals (Sweden)

    Dafiqiy Ya’lu Ulin Nuha, Novi Avisena

    2012-05-01

    Full Text Available Telah dilakukan penelitian dengan metode geomagnetik pada tanggal 26 -27 April 2011 di daerah Songgoriti Kota Batu dengan tujuan untuk mengetahui pola Anomali Magnet Total dan struktur geologi bawah permukaan. Setelah dilakukan koreksi data yang meliputi koreksi diurnal dan koreksi IGRF maka didapatkan nilai anomali magnet total serta kontinuasi ke atas dan reduksi ke kutub. Selanjutnya dilakukan interpretasi secara kualitatif dan kuantitatif. Interpretasi kuantitatif dilakukan dengan membaca pola kontur anomali magnet lokal dan reduksi ke kutub, sedangkan interpretasi kualitatif dilakukan dengan membuat penampang 2,5 D pada dua lintasan AB dan CD. Berdasarkan interpretasi kuantitatif pada kontur anomali  magnetik lokal didapatkan variasi nilai anomali antara -800 nT-600 nT dengan anomali tinggi terdapat pada arah timur dan barat daerah penelitian, anomali sedang terletak pada daerah tengah penelitian dan anomali rendah terdapat pada sedikit   daerah   tengah   penelitian.   Daerah   penelitian   didominasi   anomali   magnetik   sedang. Berdasarkan interpretasi kualitatif pada model penampang 2,5 D lintasan AB dan CD, didapatkan tujuh body yaitu batuan tufa, batuan tufa, batuan breksi vulkanik, batuan breksi tufaan, batuan lava, batuan basalt, dan batuan andesit. Berdasarkan sifat fisik dari tiap lapisan batuan, diduga batuan sarang dalam sistem geothermal yang berupa sumber air panas di daerah penelitian adalah batuan breksi vulkanik dengan batuan penutup (cap rock berupa batuan tufa. Kata Kunci : Anomali Magnet, Struktur Geologi, Air Panas.

  4. Memori English Irregular Verbs Berdasarkan Frekuensi Pengulangan dan Jenis Kelamin Santri

    Directory of Open Access Journals (Sweden)

    H. Sribagus

    2013-01-01

    Full Text Available Abstract: Retention of English Irregular Verbs in Relation to Repetition Frequency and Sex. The study explores the most effective and preferred repetition frequency to facilitate memorizing English ir­regular verbs (EIV by students of different sexes, 35 male students and 30 female students of an Islamic boarding school in West Nusa Tenggara. The data for this experimental study were collected through VCD that records EIV, tests, questionnaires, and interviews. The results of the two-way ANOVA analysis indicate that male students had a higher degree of EIV memory based on repetition frequency, with two-time repetition as the most preferred frequency. For male students, the higher the frequency, the lower the memory. Abstrak: Memori English Irregular Verbs Berdasarkan Frekuensi Pengulangan dan Jenis Kelamin Santri. Penelitian ini bertujuan untuk menentukan frekuensi pengulangan yang efektif dan disukai untuk meningkatkan memori EIV berdasarkan jenis kelamin. Data penelitian eksperimen ini dikumpulkan melalui video compact disk (VCD yang merekam English Irregular Verb, tes, angket dan wawancara terhadap 35 santri putra dan 30 santri putri di pondok pesantren di Nusa Tenggara Barat. Kemudian data dianalisis dengan Anava-dua Jalur. Ditemukan bahwa ada perbedaan taraf memori EIV berdasarkan frekuensi pengulangan antara santri putra dan santri putriMemori EIV santri putra lebih tinggi daripada santri putri. Frekuensi pengulangan yang paling efektif adalah dua kali. Semakin tinggi frekuensi pengulangan, semakin rendah memori. Urutan pilihan frekuensi santri putra adalah 2-4-6, sedangkan santri putri 2-6-4.

  5. The Neutronic Effect of Zr-rod and Sm2O3-disk in the Model of Kartini Reactor Fuel Element

    International Nuclear Information System (INIS)

    The model of Kartini fuel element has been constructed using a variationof materials in it fuels. For basic model, the construction of fuel assemblyis a rod type fuel element with SS-304 cladding and UZrH (8.5 % wt U in 20 %enrichment) as a fuel meat and graphite reflector at the both ends of fuelmeat. By using is basic construction, the material then varied in 4 models asthe following: 1) The model with the Zr-rod in 5.76 mm diameter, is insertedat the axis of fuel meat; 2) The model with Sm2O3-disk in 1.28 mmthickness, is inserted at the both ends of fuel meat; 3) The compound ofmodel 1 and model 2; 4) The basic construction of cell without Zr-rod andSm2O3-disk. The neutronic-behavior of each model then calculated usingWIMSD4 and the result then represented as a graphics form of the correlationof parameters as the following: 1) The correlation between model and itneutron multiplication factor; 2) The comparison of neutron flux distributionfor each model. By the graphic can be concluded, that Zr-rod in the fuelelement can reduce power peaking factor to 82 % with the effect of neutronmultiplication factor reduced to 98 %, while the insertion of Sm2O3-disk atthe both ends of fuel meat can make neutron multiplication factor reduce to97 % but unfortunately the neutron peaking factor increase to 101 %. Theinsertion of Zr-rod in the axis of fuel meat, increase the safety margin offuel utilization, while the insertion of Sm2O3-disk at the both ends offuel meat can make it as the burn-able poison that maintain the neutronmultiplication factor stable for a long time utilization. (author)

  6. ATR-mediated regulation of nuclear and cellular plasticity.

    Science.gov (United States)

    Kidiyoor, Gururaj Rao; Kumar, Amit; Foiani, Marco

    2016-08-01

    ATR (Ataxia Telangiectasia and Rad3-related) is a member of the Phosphatidylinositol 3-kinase-related kinases (PIKKs) family, amongst six other vertebrate proteins known so far. ATR is indispensable for cell survival and its essential role is in sensing DNA damage and initiating appropriate repair responses. In this review we highlight emerging and recent observations connecting ATR to alternative roles in controlling the nuclear envelope, nucleolus, centrosome and other organelles in response to both internal and external stress conditions. We propose that ATR functions control cell plasticity by sensing structural deformations of different cellular components, including DNA and initiating appropriate repair responses, most of which are yet to be understood completely. PMID:27283761

  7. LWRS ATR Irradiation Testing Readiness Status

    Energy Technology Data Exchange (ETDEWEB)

    Kristine Barrett

    2012-09-01

    The Light Water Reactor Sustainability (LWRS) Program was established by the U.S. Department of Energy Office of Nuclear Energy (DOE-NE) to develop technologies and other solutions that can improve the reliability, sustain the safety, and extend the life of the current reactors. The LWRS Program is divided into four R&D Pathways: (1) Materials Aging and Degradation; (2) Advanced Light Water Reactor Nuclear Fuels; (3) Advanced Instrumentation, Information and Control Systems; and (4) Risk-Informed Safety Margin Characterization. This report describes an irradiation testing readiness analysis in preparation of LWRS experiments for irradiation testing at the Idaho National Laboratory (INL) Advanced Test Reactor (ATR) under Pathway (2). The focus of the Advanced LWR Nuclear Fuels Pathway is to improve the scientific knowledge basis for understanding and predicting fundamental performance of advanced nuclear fuel and cladding in nuclear power plants during both nominal and off-nominal conditions. This information will be applied in the design and development of high-performance, high burn-up fuels with improved safety, cladding integrity, and improved nuclear fuel cycle economics

  8. Validation of helios for ATR core follow analysis

    International Nuclear Information System (INIS)

    This work summarizes the validation analyses for the HELIOS code to support core design and safety assurance calculations of the Advanced Test Reactor (ATR). Past and current core safety assurance is performed by the PDQ-7 diffusion code; a state of the art reactor physics simulation tool from the nuclear industry's earlier days. Over the past twenty years, improvements in computational speed have enabled the use of modern neutron transport methodologies to replace the role of diffusion theory for simulation of complex systems, such as the ATR. More exact methodologies have enabled a paradigm-shift away from highly tuned codes that force compliance with a bounding safety envelope, and towards codes regularly validated against routine measurements. To validate HELIOS, the 16 ATR operational cycles from late-2009 to present were modeled. The computed power distribution was compared against data collected by the ATR's on-line power surveillance system. It was found that the ATR's lobe-powers could be determined with ±10% accuracy. Also, the ATR's cold startup shim configuration for each of these 16 cycles was estimated and compared against the reported critical position from the reactor log-book. HELIOS successfully predicted criticality within the tolerance set by the ATR startup procedure for 13 out of the 16 cycles. This is compared to 12 times for PDQ (without empirical adjustment). These findings, as well as other insights discussed in this report, suggest that HELIOS is highly suited for replacing PDQ for core safety assurance of the ATR. Furthermore, a modern verification and validation framework has been established that allows reactor and fuel performance data to be computed with a known degree of accuracy and stated uncertainty. (author)

  9. Preliminary Discrimination of Butter Adulteration by ATR-FTIR Spectroscopy

    OpenAIRE

    Lucian Cuibus; Rubén Maggio; Vlad Mureșan; Zorița Diaconeasa; Oana Lelia Pop; Carmen Socaciu

    2015-01-01

    The Attenuated Total Reflectance-Fourier Transform Infrared Spectroscopy (ATR-FTIR)  was applied for the discrimination of butter samples adulterated with solid fraction of palm oil. For FTIR fingerprinting of butter samples, with or without controlled additions of palm oil as adulterant was firstly obtained, using a Shimatsu Prestige 21 Spectrophotometer, including a horizontal diamond ATR accessory with reflection in the MIR region (3873-690) cm-1.The spiked butter samples including 0 level...

  10. ATR National Scientific User Facility 2009 Annual Report

    Energy Technology Data Exchange (ETDEWEB)

    Todd R. Allen; Mitchell K. Meyer; Frances Marshall; Mary Catherine Thelen; Jeff Benson

    2010-11-01

    This report describes activities of the ATR NSUF from FY-2008 through FY-2009 and includes information on partner facilities, calls for proposals, users week and education programs. The report also contains project information on university research projects that were awarded by ATR NSUF in the fiscal years 2008 & 2009. This research is university-proposed researcher under a user facility agreement. All intellectual property from these experiments belongs to the university per the user agreement.

  11. Validation of HELIOS for ATR Core Follow Analyses

    International Nuclear Information System (INIS)

    This work summarizes the validation analyses for the HELIOS code to support core design and safety assurance calculations of the Advanced Test Reactor (ATR). Past and current core safety assurance is performed by the PDQ-7 diffusion code; a state of the art reactor physics simulation tool from the nuclear industry's earlier days. Over the past twenty years, improvements in computational speed have enabled the use of modern neutron transport methodologies to replace the role of diffusion theory for simulation of complex systems, such as the ATR. More exact methodologies have enabled a paradigm-shift away from highly tuned codes that force compliance with a bounding safety envelope, and towards codes regularly validated against routine measurements. To validate HELIOS, the 16 ATR operational cycles from late-2009 to present were modeled. The computed power distribution was compared against data collected by the ATR's on-line power surveillance system. It was found that the ATR's lobe-powers could be determined with ±10% accuracy. Also, the ATR's cold startup shim configuration for each of these 16 cycles was estimated and compared against the reported critical position from the reactor log-book. HELIOS successfully predicted criticality within the tolerance set by the ATR startup procedure for 13 out of the 16 cycles. This is compared to 12 times for PDQ (without empirical adjustment). These findings, as well as other insights discussed in this report, suggest that HELIOS is highly suited for replacing PDQ for core safety assurance of the ATR. Furthermore, a modern verification and validation framework has been established that allows reactor and fuel performance data to be computed with a known degree of accuracy and stated uncertainty.

  12. ATR National Scientific User Facility 2009 Annual Report

    International Nuclear Information System (INIS)

    This report describes activities of the ATR NSUF from FY-2008 through FY-2009 and includes information on partner facilities, calls for proposals, users week and education programs. The report also contains project information on university research projects that were awarded by ATR NSUF in the fiscal years 2008 and 2009. This research is university-proposed researcher under a user facility agreement. All intellectual property from these experiments belongs to the university per the user agreement.

  13. Assessment of COTS IR image simulation tools for ATR development

    Science.gov (United States)

    Seidel, Heiko; Stahl, Christoph; Bjerkeli, Frode; Skaaren-Fystro, Paal

    2005-05-01

    Following the tendency of increased use of imaging sensors in military aircraft, future fighter pilots will need onboard artificial intelligence e.g. ATR for aiding them in image interpretation and target designation. The European Aeronautic Defence and Space Company (EADS) in Germany has developed an advanced method for automatic target recognition (ATR) which is based on adaptive neural networks. This ATR method can assist the crew of military aircraft like the Eurofighter in sensor image monitoring and thereby reduce the workload in the cockpit and increase the mission efficiency. The EADS ATR approach can be adapted for imagery of visual, infrared and SAR sensors because of the training-based classifiers of the ATR method. For the optimal adaptation of these classifiers they have to be trained with appropriate and sufficient image data. The training images must show the target objects from different aspect angles, ranges, environmental conditions, etc. Incomplete training sets lead to a degradation of classifier performance. Additionally, ground truth information i.e. scenario conditions like class type and position of targets is necessary for the optimal adaptation of the ATR method. In Summer 2003, EADS started a cooperation with Kongsberg Defence & Aerospace (KDA) from Norway. The EADS/KDA approach is to provide additional image data sets for training-based ATR through IR image simulation. The joint study aims to investigate the benefits of enhancing incomplete training sets for classifier adaptation by simulated synthetic imagery. EADS/KDA identified the requirements of a commercial-off-the-shelf IR simulation tool capable of delivering appropriate synthetic imagery for ATR development. A market study of available IR simulation tools and suppliers was performed. After that the most promising tool was benchmarked according to several criteria e.g. thermal emission model, sensor model, targets model, non-radiometric image features etc., resulting in a

  14. FLUX SENSOR EVALUATIONS AT THE ATR CRITICAL FACILITY

    International Nuclear Information System (INIS)

    The Advanced Test Reactor (ATR) and the ATR Critical (ATRC) facilities lack real-time methods for detecting thermal neutron flux and fission reaction rates for irradiation capsules. Direct measurements of the actual power deposited into a test are now possible without resorting to complicated correction factors. In addition, it is possible to directly measure minor actinide fission reaction rates and to provide time-dependent monitoring of the fission reaction rate or fast/thermal flux during transient testing. A joint Idaho State University/Idaho National Laboratory ATR National Scientific User Facility (ATR NSUF) project was recently initiated to evaluate new real-time state-of-the-art in-pile flux detection sensors. Initially, the project is comparing the accuracy, response time, and long duration performance of French Atomic Energy Commission (CEA)-developed miniature fission chambers, specialized self-powered neutron detectors (SPNDs) by the Argentinean National Energy Commission (CNEA), specially developed commercial SPNDs, and back-to-back fission (BTB) chambers developed by Argonne National Laboratory (ANL). As discussed in this paper, specialized fixturing and software was developed by INL to facilitate these joint ISU/INL evaluations. Calculations were performed by ISU to assess the performance of and reduce uncertainties in flux detection sensors and compare data obtained from these sensors with existing integral methods employed at the ATRC. Ultimately, project results will be used to select the detector that can provide the best online regional ATRC power measurement. It is anticipated that project results may offer the potential to increase the ATRC's current power limit and its ability to perform low-level irradiation experiments. In addition, results from this effort will provide insights about the viability of using these detectors in the ATR. Hence, this effort complements current activities to improve ATR software tools, computational protocols

  15. "ATR activation in response to ionizing radiation: still ATM territory"

    Directory of Open Access Journals (Sweden)

    Cuadrado Myriam

    2006-05-01

    Full Text Available Abstract Unrepaired DNA double-strand breaks (DSBs are a major cause for genomic instability. Therefore, upon detection of a DSB a rapid response must be assembled to coordinate the proper repair/signaling of the lesion or the elimination of cells with unsustainable amounts of DNA damage. Three members of the PIKK family of protein kinases -ATM, ATR and DNA-PKcs- take the lead and initiate the signaling cascade emanating from DSB sites. Whereas DNA-PKcs activity seems to be restricted to the phosphorylation of targets involved in DNA repair, ATM and ATR phosphorylate a broad spectrum of cell cycle regulators and DNA repair proteins. In the canonical model, ATM and ATR are activated by two different types of lesions and signal through two independent and alternate pathways. Specifically, ATR is activated by various forms of DNA damage, including DSBs, arising at stalled replication forks ("replication stress", and ATM is responsible for the signaling of DSBs that are not associated with the replication machinery throughout the cell cycle. Recent evidence suggests that this model might be oversimplified and that coordinated crosstalk between ATM and ATR activation routes goes on at the core of the DNA damage response.

  16. An add-on cap for ATR-IR spectroscopy studies

    DEFF Research Database (Denmark)

    2014-01-01

    The invention relates to a cap (300B) for an attenuated total reflectance infrared (ATR-IR) spectrometer, the ATR-IR spectrometer comprising an ATR-IR plate (200). The cap (300B) comprises an ATR- IR plate facing cap surface. When the ATR-IR plate facing cap surface is placed on the sample surfac...... as cap securing means (322), as the cap (300B) is secured onto the ATR-IR plate (200) by a pressure clamp (108) and an arm (110) holding the pressure clamp (108) pressing on the bridge (322)....

  17. Homeostatic regulation of meiotic DSB formation by ATM/ATR

    Energy Technology Data Exchange (ETDEWEB)

    Cooper, Tim J.; Wardell, Kayleigh; Garcia, Valerie; Neale, Matthew J., E-mail: m.neale@sussex.ac.uk

    2014-11-15

    Ataxia–telangiectasia mutated (ATM) and RAD3-related (ATR) are widely known as being central players in the mitotic DNA damage response (DDR), mounting responses to DNA double-strand breaks (DSBs) and single-stranded DNA (ssDNA) respectively. The DDR signalling cascade couples cell cycle control to damage-sensing and repair processes in order to prevent untimely cell cycle progression while damage still persists [1]. Both ATM/ATR are, however, also emerging as essential factors in the process of meiosis; a specialised cell cycle programme responsible for the formation of haploid gametes via two sequential nuclear divisions. Central to achieving accurate meiotic chromosome segregation is the introduction of numerous DSBs spread across the genome by the evolutionarily conserved enzyme, Spo11. This review seeks to explore and address how cells utilise ATM/ATR pathways to regulate Spo11-DSB formation, establish DSB homeostasis and ensure meiosis is completed unperturbed.

  18. UJI KUALITAS MINYAK GORENG BERDASARKAN INDEKS BIAS CAHAYA MENGGUNAKAN ALAT REFRAKTOMETER SEDERHANA

    Directory of Open Access Journals (Sweden)

    Dody Rahayu Prasetyo

    2014-05-01

    Full Text Available Telah  dilakukan uji kualitas minyak goreng dengan parameter fisika indeks bias menggunakan alat refraktometer sederhana. Minyak goreng yang digunakan adalah dua jenis minyak goreng nabati yang berbeda yaitu minyak goreng A dan B. Masing-masing minyak goreng dipanaskan dengan menambahkan plastik dan dilakukan sebanyak enam kali variasi massa plastik. Minyak goreng panas tersebut dimasukkan ke dalam refraktometer kemudian ditembakan sinar laser melalui salah satu sisi dan diamati sinar yang keluar dari sisi yang lain. Penentuan nilai indeks bias minyak goreng didasarkan pada hukum Snellius dengan cara mengukur jarak sinar bias terhadap garis normal. Kualitas minyak goreng ditentukan berdasarkan nilai indeks bias. Dari hasil penelitian didapatkan bahwa semakin banyak kandungan plastik di dalam minyak goreng, semakin besar pula indeks bias minyak goreng tersebut. Dapat dipahami, laju sinar di dalam minyak goreng semakin berkurang dengan bertambahnya partikel plastik. Jadi, peran partikel plastik sebagai faktor penghambat laju sinar. Berdasarkan hasil penelitian dapat disimpulkan bahwa minyak goreng yang mempunyai indeks bias besar yang terindikasi mengandung plastik memiliki kualitas buruk. Untuk minyak goreng merk A setelah dicampur plastik 1 gram dan 11 gram masing-masing memiliki indeks bias 1,351 dan 1,443. Untuk minyak goreng merk B setelah dicampur plastik 1 gram dan 11 gram  masing-masing memiliki indeks bias 1,297 dan 1,492.

  19. Sistem Sensor Kualitas Minyak Goreng Berdasarkan pada Pengukuran Kapasitansi dan Panjang Berkas Pembiasan Cahaya

    Directory of Open Access Journals (Sweden)

    Zulfan Syah Putra

    2013-03-01

    Full Text Available Minyak merupakan salah satu kebutuhan pokok manusia. Kualitas suatu minyak sangat penting diketahui, karena setiap minyak dengan jenis yang sama mempunyai kualitas yang berbeda. Oleh karena itu, perlu dibuat sebuah teknologi yang tepat guna dan ekonomis untuk mengetahui kualitas minyak tersebut. Pada tugas akhir ini penulis telah membuat Sistem Sensor kualitas Minyak Berdasarkan Pada Pengukuran Kapasitansi Dan Panjang Berkas Pembiasan Cahaya. Sistem untuk pengukuran kapasitansi bekerja menggunakan astabel multivibrator dengan frekuensi 50,332  Khz. Frekuensi  50,332  khz ini selanjutnya dirubah ke tegangan dengan menggunakan F to V konverter. Rangkaian F to V konverter yang dirancang mampu bekerja dari frekuensi 1khz-100 khz. Data tegangan yang diperoleh dari f to v konverter ini akan di baca oleh mikrokontroller sebagai data ADC 10 bit. Dengan berubahnya frekuensi, maka data ADC akan berubah. Untuk panjang berkas pembiasan cahaya, sistem ini menggunakan webcam yang berbasis komputer untuk menghitung panjang berkas pembiasan cahaya dengan mendapatkan nilai pixel setiap sampel minyak. Berdasarkan pengujian didapatkan bahwa sistem ini dapat membedakan kualitas minyak yang meliputi minyak goreng murni, minyak goreng bekas, oli murni, oli bekas

  20. Tinjauan Teologis: Allah Menyesal Berdasarkan Perspektif Kitab Kejadian Pasal 6:6-7

    Directory of Open Access Journals (Sweden)

    Yetris Elbaar

    2013-10-01

    Full Text Available Tujuan penelitian ini adalah Pertama, untuk menjelaskan makna Allahmenyesal melalui pemaparan eksposisi nas di dalam kitab Kejadian 6:6-7, supayadapat menghasilkan kerangka pemahaman yang benar tentang Allah sebagaiPencipta. Kedua, untuk mendapatkan pemahaman yang benar mengenai Allahmenyesal berdasarkan penjelasan implikasi teologis. Ketiga, supaya orang percayadapat mengerti makna mengenai Allah menyesal dalam kitab Kejadian 6:6-7 yangdijabarkan dalam implikasi praktis.Penulisan karya ilmiah ini menggunakan metodologi eksposisi, denganmenggunakan prinsip-prinsip hermeneutika, yaitu dengan kajian eksegesis Alkitabmengenai Allah menyesal berdasarkan Kejadian 6:6-7 dan melalui penelitiankualitatif, yaitu dengan penggunaan buku-buku di perpustakaan yang berkaitandengan konsep judul karya ilmiah.Kesimpulan karya ilmiah ini adalah: Pertama, Allah yang menyesal adalahAllah yang konsisten terhadap sifat dan karakter-Nya. Kedua, Allah yang menyesaladalah Allah yang harus dipahami melalui konteks firman Tuhan. Berdasarkankonteks Kejadian 6:6-7 Allah menyesal adalah Allah yang menyatakan pengakuan-Nya sebagai pencipta (6:6. Dan Mengungkapkan keputusan Allah (6:7. Ketiga,Allah menyesal adalah Allah yang tidak dapat menyangkal diri-Nya sebagai Allahyang ingin menyatakan bahwa Ia sangat berduka, tetapi harus menyatakankeadilannya sebagai Allah dan harus menghukum kejahatan manusia. Keempat,Allah menyesal adalah Allah yang menghendaki supaya manusia hidup dalamperaturan dan hukum-hukum yang Allah tetapkan dalam kehidupannya.

  1. Monitoring Theophylline Concentrations in Saline Using Terahertz ATR Spectroscopy

    Directory of Open Access Journals (Sweden)

    Kei Takeya

    2016-03-01

    Full Text Available To assess the possibility of terahertz technology for the determination of drug concentration in blood, we endeavored to apply a terahertz (THz attenuated total reflection (ATR method to measure the levels of theophylline in saline. A change in reflected THz wave amplitude was observed in a theophylline concentration-dependent manner. This result was obtained with simple measurements of comparisons of the amplitude of the reflected wave, and suggests that it is possible to monitor concentration changes of drugs in liquid material using THz ATR measurements.

  2. Design and implementation of an embedded software system for ATR

    Science.gov (United States)

    Wang, Yuehuan; Li, Shiyong

    2011-11-01

    This paper has designed and realized a coarse-grained, unbalanced, modularized parallel embedded software system for ATR. According to the characteristics of ATR algorithms, some control modules such as system monitoring, task assignment and hierarchical algorithm modules are realized in our system. There are different design principles for different modules. The task assignment module combines different modules into clusters based on mutually exclusive modules, and assigns them to different processors. The principle of combination is the minimum variance of load on different processors. The system satisfies the requirement of real-time performance due to this reasonable strategy for task assignment, with the flexibility and scalability significantly improved.

  3. Rancangan Fasilitas Kerja Ergonomis Pada Stasiun Pencetakan Dengan Metode Pahl Dan Beitz Berdasarkan Analisa Postur Kerja Metode Mantra

    OpenAIRE

    Hakim, M. Fadhil

    2014-01-01

    Proses rancang bangun fasilitas kerja merupakan suatu faktor penting dalam menunjang peningkatan pelayanan jasa produksi. Fasilitas kerja yang dirancang tidak ergonomis akan menimbulkan dampak negatif bagi pekerja yang menggunakannya baik dalam jangka pendek maupun jangka panjang seperti nyeri dan kelelahan. Berdasarkan penelitian yang dilakukan pada dua operator stasiun pencetakan kerupuk putih di UD.Ngatimin melalui Standard Nordict Questionnaire diperoleh bahwa keluhan tertinggi terdapat...

  4. ATR cooperates with CTC1 and STN1 to maintain telomeres and genome integrity in Arabidopsis

    OpenAIRE

    Boltz, Kara A.; Leehy, Katherine; Song, Xiangyu; Nelson, Andrew D.; Shippen, Dorothy E.

    2012-01-01

    The CTC1/STN1/TEN1 (CST) complex is an essential constituent of plant and vertebrate telomeres. Here we show that CST and ATR (ataxia telangiectasia mutated [ATM] and Rad3-related) act synergistically to maintain telomere length and genome stability in Arabidopsis. Inactivation of ATR, but not ATM, temporarily rescued severe morphological phenotypes associated with ctc1 or stn1. Unexpectedly, telomere shortening accelerated in plants lacking CST and ATR. In first-generation (G1) ctc1 atr muta...

  5. FTIR-ATR imaging of coated oil capsules

    International Nuclear Information System (INIS)

    Complete text of publication follows. Coated oil capsules are used to deliver new functional food ingredients. In this study spherical capsules were investigated containing a core with fish oil coated with a transparent gelatine layer. The remaining actives are within a hard coating, which is applied on the gelatine capsules. For the microstructural characterization of the coating the following techniques were used: Fourier Transform Infrared (FTIR) microscopy using an Attenuated Total Reflection (ATR) crystal, Light Microscopy (LM), X-ray microtomography (μCT) and Scanning Electron Microscopy (SEM). For FTIR-ATR imaging the oil capsules were embedded in epoxy resin. The embedded sample was trimmed in a microtome using a glass knife for the initial rough trimming. For the final fracture a diamond knife was used to obtain the best possible surface. A Ge-crystal was brought in contact with the surface of interest. LM images were obtained using the visible light camera of the FTIR system. A principal component analysis was performed on the FTIR-ATR imaging showing the spatial distribution of some of the compounds. This study demonstrated that imaging techniques can be used to analyse the microstructure of coated oil capsules. Correlative microscopy of techniques like FTIR-ATR imaging, LM, XRT and SEM-EDX results in useful information about the spatial distribution of the chemical compounds and layer thickness of solid food samples.

  6. ATR Prohibits Replication Catastrophe by Preventing Global Exhaustion of RPA

    DEFF Research Database (Denmark)

    Toledo Lazaro, Luis Ignacio; Altmeyer, Matthias; Rask, Maj-Britt;

    2013-01-01

    origin firing generates an excess of single-stranded DNA that exhausts the nuclear pool of RPA. Partial reduction of RPA accelerated fork breakage, and forced elevation of RPA was sufficient to delay such "replication catastrophe" even in the absence of ATR activity. Conversely, unscheduled origin firing...

  7. Validation of HELIOS for ATR Core Follow Analyses

    Energy Technology Data Exchange (ETDEWEB)

    Bays, Samuel E. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Swain, Emily T. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Crawford, Douglas S. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Nigg, David W. [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2015-03-01

    This work summarizes the validation analyses for the HELIOS code to support core design and safety assurance calculations of the Advanced Test Reactor (ATR). Past and current core safety assurance is performed by the PDQ-7 diffusion code; a state of the art reactor physics simulation tool from the nuclear industry’s earlier days. Over the past twenty years, improvements in computational speed have enabled the use of modern neutron transport methodologies to replace the role of diffusion theory for simulation of complex systems, such as the ATR. More exact methodologies have enabled a paradigm-shift away from highly tuned codes that force compliance with a bounding safety envelope, and towards codes regularly validated against routine measurements. To validate HELIOS, the 16 ATR operational cycles from late-2009 to present were modeled. The computed power distribution was compared against data collected by the ATR’s on-line power surveillance system. It was found that the ATR’s lobe-powers could be determined with ±10% accuracy. Also, the ATR’s cold startup shim configuration for each of these 16 cycles was estimated and compared against the reported critical position from the reactor log-book. HELIOS successfully predicted criticality within the tolerance set by the ATR startup procedure for 13 out of the 16 cycles. This is compared to 12 times for PDQ (without empirical adjustment). These findings, as well as other insights discussed in this report, suggest that HELIOS is highly suited for replacing PDQ for core safety assurance of the ATR. Furthermore, a modern verification and validation framework has been established that allows reactor and fuel performance data to be computed with a known degree of accuracy and stated uncertainty.

  8. Integrate knowledge acquisition with target recognition through closed-loop ATR

    Science.gov (United States)

    Yu, Ssu-Hsin; McLaughlin, Pat; Zatezalo, Aleksandar; Hsiao, Kai-yuh; Boskovic, Jovan

    2015-05-01

    Automatic Target Recognition (ATR) algorithm performance is highly dependent on the sensing conditions under which the input data is collected. Open-loop fly-bys often produce poor results due to less than ideal measurement conditions. In addition, ATR algorithms must be extremely complicated to handle the diverse range of inputs with a resulting reduction in overall performance and increase in complexity. Our approach, closed-loop ATR (CL-ATR), focuses on improving the quality of information input to the ATR algorithms by optimizing motion, sensor settings and team (vehicle-vehicle-human) collaboration to dramatically improve classification accuracy. By managing the data collection guided by predicted ATR performance gain, we increase the information content of the data and thus dramatically improve ATR performance with existing ATR algorithms. CL-ATR has two major functions; first, an ATR utility function, which represents the performance sensitivity of ATR produced classification labels as a function of parameters that correlate to vehicle/sensor states. This utility function is developed off-line and is often available from the original ATR study as a confusion matrix, or it can be derived through simulation without direct access to the inner working of the ATR algorithm. The utility function is inserted into our CLATR framework to autonomously control the vehicle/sensor. Second, an on-board planner maps the utility function into vehicle position and sensor collection plans. Because we only require the utility function on-board, we can activate any ATR algorithm onto a unmanned aerial vehicle (UAV) platform no matter how complex. This pairing of ATR performance profiles with vehicle/sensor controls creates a unique and powerful active perception behavior.

  9. Perbandingan Konsumsi Lemak Berdasarkan Tingkat Keparahan Akne Vulgaris pada Siswa SMK Negeri 1 Kota Jambi

    Directory of Open Access Journals (Sweden)

    Nisa Sulistia

    2015-09-01

    Full Text Available Abstrak Salah satu faktor pencetus akne vulgaris adalah diet tinggi lemak, terutama lemak jenuh. Tujuan penelitian ini adalah untuk mengetahui perbandingan konsumsi lemak berdasarkan tingkat keparahan akne vulgaris menurut kriteria Lehmann. Penelitian ini berupa studi analitik observasional dengan desain cross sectional melalui pemeriksaan statusdermatologikus menurut kriteria Lehmann dan pengambilan data konsumsi menggunakan FFQ (Food Frequency Questionnaire pada 138 siswa kelas X dan XI SMK Negeri 1 Kota Jambi. Hasil penelitian menunjukkan terdapat akne vulgaris derajat ringan (49%, akne vulgaris derajat sedang (42%, dan akne vulgaris derajat berat (9%. Reratakonsumsi lemak total 89,35 ± 17,63 gram. Rerata konsumsi SFA (Saturated Fatty Acid 37,07 ± 9,97 gram. Rerata konsumsi MUFA (Monounsaturated Fatty Acid 15,30 ± 11,79 gram. Rerata konsumsi PUFA (Polyunsaturated Fatty Acid 12,03 ± 9,25 gram.Uji oneway Anova menunjukkan tidak ada perbedaan bermakna rerata konsumsi lemak total (p > 0,05 dan SFA (p > 0,05 berdasarkan tingkat keparahan akne vulgaris. Uji Kruskal-Wallis menunjukkan tidak ada perbedaan bermakna MUFA (p > 0,05, dan PUFA (p > 0,05 berdasarkan tingkat keparahan akne vulgaris. Penelitian ini menunjukkan tidak ada perbedaan konsumsi lemak berdasarkan tingkat keparahan akne vulgaris pada siswa SMKNegeri 1 Kota Jambi.Kata kunci: akne vulgaris, FFQ, lemak total, SFA, MUFA, PUFA Abstract One of the precipited factors is high fat diet, especially saturated fats. The objective of this study was to determine the comparison of fat consumption which is based on the severity of acne vulgaris.This research wasanalytic observational study using cross sectional design, by examining dermatologic status according to Lehmann criteria and  taking consumption record with FFQ (Food Frequency Questionnaire of  138 tenth and eleventh grade student in SMKN 1 Jambi. The result showed that mild acne vulgaris (49%, moderate acne vulgaris (42%, and

  10. PRODUKTIVITAS TENAGA PENGARIT BERDASARKAN MODA PENGANGKUT DI PETERNAKAN SAPI PERAH PONDOK RANGGON, JAKARTA TIMUR

    Directory of Open Access Journals (Sweden)

    Iwan Prihantoro

    2015-06-01

    Full Text Available Penelitian ini bertujuan untuk menganalisis produktivitas tenaga pengarit dan efektivitasnya berdasarkan moda pengangkut yang dipergunakan di peternakan sapi perah Pondok Ranggon, Jakarta Timur. Peternakan sapi perah Pondok Rangon merupakan salah satu peternakan yang masih bertahan di DKI Jakarta yang ketersediaan hijauan pakannya berasal pada padang rumput alam. Penelitian didasarkan pada sumber data primer dan sekunder dengan cara sensus dari total 22 peternak. Hasil penelitian menunjukkan bahwa karakteristik peternak di Pondok Rangon 40,91% telah berumur > 55 tahun dan 45,46% telah memiliki pengalaman >20 tahun. Kapasitas mengarit tertinggi pada umur 38 tahun (395 kg/hari dan moda truck lebih efisien dalam penyediaan hijauan dibanding pick up dan becak motor.

  11. Analisis keragaman manggis (Garcinia mangostana diiradiasi dengan sinar gamma berdasarkan karakteristik morfologi dan anatomi

    Directory of Open Access Journals (Sweden)

    ALFIN WIDIASTUTI

    2010-11-01

    Full Text Available Abstrak. Widiastuti A, Sobir, Suhartanto MR. 2010. Analisis keragaman manggis (Garcinia mangostana diiradiasi dengan sinar gamma berdasarkan karakteristik morfologi dan anatomi. Bioteknologi 7: 85-98. Tujuan penelitian ini adalah meningkatkan keragaman genetik manggis (Garcinia mangostana L. yang diiradiasi dengan sinar gamma dosis 0 Gy, 20 Gy, 25 Gy, 30 Gy, 35 Gy dan 40 Gy. Bahan tanaman yang digunakan adalah biji yang dikumpulkan dari Kampung Cegal, Desa Karacak, Kecamatan Leuwiliang, Kabupaten Bogor, Jawa Barat. Data dihasilkan dari karakteristik morfologi dan anatomi. Hasil penelitian menunjukkan bahwa peningkatan dosis sinar gamma dapat menghambat pertumbuhan benih, sehingga membutuhkan waktu lebih lama untuk tumbuh dan menurunkan viabilitas benih. Secara morfologi, hal itu juga menurunkan tinggi tanaman, diameter batang, ukuran daun, dan jumlah daun. Secara anatomi, kepadatan stomata berkorelasi positif dengan tinggi tanaman dengan nilai korelasi adalah 90% dan 74%. Iradiasi sinar gamma dapat meningkatkan keragaman morfologi hingga 30%. Pemotongan benih setelah iradiasi dapat meningkatkan keragaman dan tingkat kelangsungan hidup manggis.

  12. A Qualification of Kartini Water Coolant Reactor Based on Data by Flame Atomic Absorption Spectrometry (F-AAS) and Ion Selective Electrode (ISE) Methods

    International Nuclear Information System (INIS)

    A water coolant reactor represent one of product at reactor cooler system in nuclear reactor. Quality assurance of water coolant reactor needed to fulfilled of conditioned such as the content of Fe, Mn, Mg, Na, Cr, Ca and Cl elements in water coolant reactor < 1 ppm. The content of Fe, Mn, Mg, Na, Cr, and Ca elements in water coolant reactor were detected by flame atomic absorption spectrometry method, while the content of Cl- element was detected by ion selective electrode (ISE). The validation of AAS instrument were done by calibration of AAS instrument using solution of Cu 2 ppm and obtained of sensitivity and precision 0.019 ppm and precision 0.65 % respectively smaller than maximum permissible 0.4 ppm and 1 % respectively. The validation of ISE instrument showed that obtained of slope in the potential ring 0.56 - 0.59 mV. The content of Ca and Cl in ATR each 0.32 ± 0.005 ppm and 1.052 ± 0.009 ppm respectively, while the other elements such as Fe, Mn, Mg, Na, and Cr under the limit of detection. Based on the data show that quality of ATR fulfilled one of the qualifications of IAEA. (author)

  13. A qualification of Kartini Water Coolant Reactor Based On Data By Flame Atomic Absorption Spectrometry (F-AAS) and Ion Selective Electrode (ISE) Methods

    International Nuclear Information System (INIS)

    A water coolant reactor represent one of product at reactor cooler system in nuclear reactor. Quality assurance of water coolant reactor needed to fulfilled of conditioned such as the content of Fe, Mn, Mg, Na, Cr, Ca and Cl elements in water coolant reactor < 1 ppm. The content of Fe, Mn, Mg, Na, Cr, and Ca elements in water coolant reactor were detected by flame atomic absorption spectrometry method, while the content of Cl- element was detected by ion selective electrode (ISE). The validation of AAS instrument were done by calibration of AAS instrument using solution of Cu 2 ppm and obtained of sensitivity and precision 0.019 ppm and precision 0.65 % respectively smaller than maximum permissible 0.4 ppm and 1 % respectively. The validation of ISE instrument showed that obtained of slope in the potential ring 0.56 - 0.59 mV. The content of Ca and Cl in ATR each 0.32 ± 0.005 ppm and 1.052 ± 0.009 ppm respectively, while the other elements such as Fe, Mn, Mg, Na, and Cr under the limit of detection. Based on the data show that quality of ATR fulfilled one of the qualifications of IAEA. (author)

  14. Comparison of HEU and LEU Fuel Neutron Spectrum for ATR Fuel Element and ATR Flux-Trap Positions

    International Nuclear Information System (INIS)

    The Advanced Test Reactor (ATR) is a high power and high neutron flux research reactor operating in the United States. Powered with highly enriched uranium (HEU), the ATR has a maximum thermal power rating of 250 MWth. Because of the high total core power and high neutron flux, the ATR is an ideal candidate for assessing the feasibility of converting an HEU driven reactor to a low-enriched core. An optimized low-enriched uranium (LEU) (U-10Mo) core conversion case, which can meet the project requirements, has been selected. However, LEU contains a significant quantity of high density U-238 (80.3 wt.%), which will harden the neutron spectrum in the core region. Based on the reference ATR HEU and the optimized LEU full core plate-by-plate (PBP) models, the present work investigates and compares the neutron spectra differences in the fuel element (FE), Northeast flux trap (NEFT), Southeast flux trap (SEFT), and East flux trap (EFT) positions. A detailed PBP MCNP ATR core model was developed and validated for fuel cycle burnup comparison analysis. The current ATR core with HEU U 235 enrichment of 93.0wt.% was used as the reference model. Each HEU fuel element contains 19 fuel plates with a fuel meat thickness of 0.508 mm (20 mil). In this work, an optimized LEU (U-10Mo) core conversion case with a nominal fuel meat thickness of 0.330 mm (13 mil) and the U-235 enrichment of 19.7 wt.% was used to calculate the impact of the neutron spectrum in FE and FT positions. MCNP-calculated results show that the neutron spectrum in the LEU FE is slightly harder than in the HEU FE, as expected. However, when neutrons transport through water coolant and beryllium (Be), the neutrons are thermalized to an equilibrium neutron spectrum as a function of water volume fraction in the investigated FT positions. As a result, the neutron spectrum differences of the HEU and LEU in the NEFT, SEFT, and EFT are negligible. To demonstrate that the LEU core fuel cycle performance can meet the

  15. FTIR-ATR imaging of TAED-detergent granules

    International Nuclear Information System (INIS)

    Complete text of publication follows. The microstructure of detergents products for textile cleaning determines to a large extent their physical properties of these products. Release of a certain compound at a given time can improve the washing effect. Tetraacetylethylenediamine (TAED) is an important ingredient of washing powder/tablets. Its function is to enhance the bleaching effect to remove stains on clothing at lower temperatures. TAED granules are post-dosed to the formulation and consist of 4 compounds e.g.; TAED, sodium sulphate, a polymer and clay. To elucidate the microstructure of the detergents granules Fourier Transform Infrared (FTIR) microscopy using an Attenuated Total Reflection (ATR) crystal and Light Microscopy (LM) were used for characterization. FTIR-ATR-imaging was performed to elucidate the location of the different compounds. A Ge-crystal was brought in contact with the surface of interest. A principal component analysis was performed on the FTIR-ATR image, thus revealing the spatial distribution of the compounds (Figure 1) within the detergent granule. The full spectra obtained in a pixel can be used for identification. Figure 1 shows the distribution of the different compounds present in the TAED granule. The structure of the granule on the right is very porous. It shows large TAED particles partially encapsulated by sulphate and surrounded by the embedding material. The clay and copolymer compounds are mainly located around inner TAED particles. Combing techniques like FTIR-ATR imaging and LM results in useful information about the spatial distribution of chemical compounds within TAED granules. The FTIR spectra are used for positively identifying the chemical compounds.

  16. Preliminary Discrimination of Butter Adulteration by ATR-FTIR Spectroscopy

    Directory of Open Access Journals (Sweden)

    Lucian Cuibus

    2015-05-01

    Full Text Available The Attenuated Total Reflectance-Fourier Transform Infrared Spectroscopy (ATR-FTIR  was applied for the discrimination of butter samples adulterated with solid fraction of palm oil. For FTIR fingerprinting of butter samples, with or without controlled additions of palm oil as adulterant was firstly obtained, using a Shimatsu Prestige 21 Spectrophotometer, including a horizontal diamond ATR accessory with reflection in the MIR region (3873-690 cm-1.The spiked butter samples including 0 level and seven increasing concentrations of palm fats, up to 50% were fingerprinted and the calibration curve was obtained (n=19. In parallel, the validation was realized using different set of spiked butter samples ranging 1-44.4 % of palm fat (n=7. Finally, an independent set of commercial samples was analized (n=14.Partial least squares (PLS model was used for statistical data processing in accordance with standard method. The value of the correlation coefficient (R2= 0.977 between actual and predicted values was statistically significant (p<0.001, considering the superposition of  "actual vs predicted” curves. This combined FTIR-PLS evaluation revealed that 3 out of  samples of butter were suspected of adulteration with palm oil, presented values 14 ranging 4-12%.In conclusion, ATR-FTIR methodology may offer an rapid evaluation of  butter samples authenticity. The low value for detection limit (3%palm oil in butter and the low limit of quantification (9.8% palm oil in butter confirms that ATR-FTIR spectroscopy  is a sensitive method to identify the adulteration of butter with  palm oil.   

  17. Neutronics analysis of the DHCE experiment in ATR-ITV

    Energy Technology Data Exchange (ETDEWEB)

    Gomes, I.C.; Smith, D.L.; Tsai, H. [Argonne National Lab., IL (United States)

    1997-08-01

    The preliminary analysis of the DHCE experiments in the ITV and ATR was performed and its was concluded that such a vehicle is suitable for this kind of experiment. It is recommended to place an extra filter material in the thermocouple sleeve (such as B-10), to improve the helium to dpa ratio profile during irradiation. Also, it was concluded that a preliminary estimation of period of time for replacement of the external filter would be around 5 dps`s.

  18. Recent ATR and fusion algorithm improvements for multiband sonar imagery

    Science.gov (United States)

    Aridgides, Tom; Fernández, Manuel

    2009-05-01

    An improved automatic target recognition processing string has been developed. The overall processing string consists of pre-processing, subimage adaptive clutter filtering, normalization, detection, data regularization, feature extraction, optimal subset feature selection, feature orthogonalization and classification processing blocks. The objects that are classified by the 3 distinct ATR strings are fused using the classification confidence values and their expansions as features, and using "summing" or log-likelihood-ratio-test (LLRT) based fusion rules. The utility of the overall processing strings and their fusion was demonstrated with new high-resolution three-frequency band sonar imagery. The ATR processing strings were individually tuned to the corresponding three-frequency band data, making use of the new processing improvement, data regularization; this improvement entails computing the input data mean, clipping the data to a multiple of its mean and scaling it, prior to feature extraction and resulted in a 3:1 reduction in false alarms. Two significant fusion algorithm improvements were made. First, a nonlinear exponential Box-Cox expansion (consisting of raising data to a to-be-determined power) feature LLRT fusion algorithm was developed. Second, a repeated application of a subset Box-Cox feature selection / feature orthogonalization / LLRT fusion block was utilized. It was shown that cascaded Box-Cox feature LLRT fusion of the ATR processing strings outperforms baseline "summing" and single-stage Box-Cox feature LLRT algorithms, yielding significant improvements over the best single ATR processing string results, and providing the capability to correctly call the majority of targets while maintaining a very low false alarm rate.

  19. Neutronics analysis of the DHCE experiment in ATR-ITV

    International Nuclear Information System (INIS)

    The preliminary analysis of the DHCE experiments in the ITV and ATR was performed and its was concluded that such a vehicle is suitable for this kind of experiment. It is recommended to place an extra filter material in the thermocouple sleeve (such as B-10), to improve the helium to dpa ratio profile during irradiation. Also, it was concluded that a preliminary estimation of period of time for replacement of the external filter would be around 5 dps's

  20. AGR-2 Data Qualification Report for ATR Cycle 154B

    Energy Technology Data Exchange (ETDEWEB)

    Binh Pham; Jeff Einerson

    2014-01-01

    This report provides the data qualification status of Advanced Gas Reactor-2 (AGR-2) fuel irradiation experimental data from Advanced Test Reactor (ATR) Cycle 154B as recorded in the Nuclear Data Management and Analysis System (NDMAS). This is the last cycle of AGR-2 irradiation, as the test train was pulled from the ATR core during the outage portion of ATR Cycle 155A. The AGR-2 data streams addressed in this report include thermocouple (TC) temperatures, sweep gas data (flow rates including new Fission Product Monitoring (FPM) downstream flows from Fission Product Monitoring System (FPMS) detectors, pressure, and moisture content), and FPMS data (release rates and release-to-birth rate ratios [R/Bs]) for each of the six capsules in the AGR-2 experiment. The final data qualification status for these data streams is determined by a Data Review Committee (DRC) comprised of AGR technical leads, Sitewide Quality Assurance (QA), and NDMAS analysts. The Data Review Committee reviewed the data acquisition process, considered whether the data met the requirements for data collection as specified in QA-approved Very High Temperature Reactor (VHTR) data collection plans, examined the results of NDMAS data testing and statistical analyses, and confirmed the qualification status of the data as given in this report.

  1. PENELITIAN PENDAHULUAN VARIASI GENETIK MASYARAKAT SOROH PANDE BERDASARKAN PENANDA DNA MIKROSATELIT KROMOSOM Y: MASYARAKAT SOROH PANDE DESA ABIANSEMAL, BADUNG

    Directory of Open Access Journals (Sweden)

    Ni Putu Putri Wulandari

    2015-02-01

    Full Text Available Masyarakat Hindu di Bali dibedakan ke dalam kelompok-kelompok berdasarkan garis keturunan laki-laki yang disebut klan atau di Bali lebih dikenal dengan istilah soroh. Salah satu soroh yang dikenal di Bali adalah soroh Pande. Penelitian ini bertujuan untuk mengetahui variasi genetik masyarakat soroh Pande di Desa Abiansemal, Badung menggunakan empat lokus mikrosatelit kromosom Y, yaitu DYS19, DYS390, DYS393 dan DYS395. Berdasarkan hasil analisis, didapatkan 11 ragam alel dan enam haplotipe yang didominasi oleh haplotipe A (200, 215, 121, 123 dengan frekuensi sebesar 0,65 serta keragaman genetik sebesar 0,32 ± 0,07. Ragam haplotipe yang didapatkan menunjukkan bahwa masyarakat soroh Pande di Desa Abiansemal berasal dari berbagai sumber gen.

  2. Struktur vertikal upwelling – downwelling di Samudera Hindia Selatan Jawa hingga Selatan Bali berdasarkan salinitas musiman periode 2004 – 2010

    OpenAIRE

    Restu Wardani; Widodo S. Pranowo; Elis Indrayanti

    2013-01-01

    Salinitas berperan penting untuk mengidentifikasi fenomena upwelling dan downwelling. Upwelling yang terjadi di samudera Hindia Selatan Jawa hingga Selatan Bali dipengaruhi oleh angin musim, ENSO (El Nino Southern Oscillation) dan IOD (Indian Oscillation Dipole Mode). Dalam peneletian ini dikaji pola upwelling dan downwelling berdasarkan distribusi salinitas secara vertikal dan vaeriabilitas musiman dikaji dalam waktu tujuh tahun (2004 – 2010). Data hasil akuisisi argo float digunakan dalam p...

  3. Analisis Deskriptif Soal Geometri dalam Buku Matematika Bilingual untuk Sekolah Menengah Pertama Kelas VIII Berdasarkan Kriteria International Assessment TIMSS 2007

    OpenAIRE

    Etik Rahayu; Hardi Suyitno; Iwan Junaedi

    2012-01-01

    Tujuan penelitian ini adalah untuk mendeskripsikan  domain kognitif dan aspek kognitif (required behavior) soal matematika dalam Buku Matematika Bilingual untuk Sekolah Menengah Pertama (SMP) Kelas VIII berdasarkan kriteria International Assessment TIMSS 2007 dan proporsinya. Metode penelitian yang digunakan adalah deskriptif kualitatif, dengan subjek penelitian adalah soal geometri dalam Buku Matematika Bilingual SMP. yang berjudul “Mathematics for Junior High School Grade VIII 1st Semest...

  4. Evaluasi Dimensi Mesin Jahit dan Kursi Operator Berdasarkan Kriteria Antropometri pada Stasiun Penjahitan di Industri Garmen UD.Chaniago.

    OpenAIRE

    Susanto, Eko

    2011-01-01

    Penelitian ini bertujuan untuk mengevaluasi mesin jahit dan kursi operator yang dipakai di stasiun penjahitan di UD.Chaniago berdasarkan perspektif dimensi antropometri pekerja. Untuk mencapai tujuan, maka dilakukan pembandingan dimensi mesin jahit dan kursi operator yang digunakan saat ini dengan dimensi ukuran antropometri pekerja dan mengindentifikasi apakah terdapat kesesuaian atau ketidaksesuaian. Ukuran dimensi antropometri tubuh pekerja dan dimensi mesin jahit dan kursi operator yang d...

  5. The ABC transporter MgAtr4 is a virulence factor of Mycosphaerella graminicola that affects colonization of substomatal cavities in wheat leaves

    NARCIS (Netherlands)

    Stergiopoulos, I.; Zwiers, L.H.; Waard, de M.A.

    2003-01-01

    The role in virulence of the ATP-binding cassette (ABC) transporters MgAtr1, MgAtr2, MgAtr3, MgAtr4, and MgAtr5 from Mycosphaerella graminicola was analyzed by gene disruption or replacement on seedlings of the susceptible wheat cultivar Obelisk. Disruption strains of MgAtr1 and MgAtr2 and replaceme

  6. ATR pathway inhibition is synthetically lethal in cancer cells with ERCC1 deficiency

    OpenAIRE

    Mohni, Kareem N.; Kavanaugh, Gina M.; Cortez, David

    2014-01-01

    The DNA damage response kinase ATR and its effector kinase CHEK1 are required for cancer cells to survive oncogene-induced replication stress. ATR inhibitors exhibit synthetic lethal interactions with deficiencies in the DNA damage response enzymes ATM and XRCC1 and with overexpression of the cell cycle kinase Cyclin E. Here we report a systematic screen to identify synthetic lethal interactions with ATR-pathway targeted drugs, rationalized by their predicted therapeutic utility in the oncolo...

  7. SISTEM IDENTIFIKASI CITRA KAYU BERDASARKAN TEKSTUR MENGGUNAKAN GRAY LEVEL COOCURRENCE MATRIX (GLCM DENGAN KLASIFIKASI JARAK EUCLIDEAN

    Directory of Open Access Journals (Sweden)

    Saifudin Saifudin

    2015-10-01

    Full Text Available Kayu jati (Tectona Grandis L.F. dan mahoni (Swietenia Mahagoni merupakan 2 jenis kayu yang biasa digunakan untuk bahan perabot rumah tangga. Perabot yang berbahan kayu jati dikenal sebagai produk kwalitas kelas 1 sedangkan perabot dengan bahan kayu mahoni dianggap sebagai produk kwalitas kelas ke 2. Namun secara manual sulit untuk membedakan antara kedua jenis kayu ini. Oleh karenanya penting dibangunnya suatu sistem otomatis yang mampu mengenali perbedaan dari kedua jenis kayu ini. Pada dasarnya citra kayu dapat dianalisis cirinya untuk mendapatkan pola-pola yang menunjukkan jenis kayu. Ekstraksi ciri dari citra kayu dapat dianalisi berdasarkan tekstur atau warnanya.Tulisan ini menjelaskan sistem identifikasi jenis kayu yang telah dikembangkan untuk membedakan antara jenis kayu jati atau mahoni. Sistem ini meliputi proses akusisi data citra, pemrosesan citra, ekstraksi ciri, dan klasifikasi. Ekstraksi ciri menggunakan tekstur Gray Level Co-ocurrence Matrix (GLCM sedangkan pengklasikasi menggunakan metode jarak Euclidean. Hasil eksperimen-eksperimen dengan pengubahan ukuran citra asli menjadi 30x30, 20x20 dan 10x10 berturut-turut menghasilkan akurasi 82,5 %, 65,7 % dan 77,5%. Hasil ini menunjukkan bahwa akurasi tertinggi yang diperoleh layak untuk diimplementasikan ke dalam industri

  8. ANALISIS PENGUNGKAPAN TANGGUNG JAWAB SOSIAL PERBANKAN SYARIAH DI INDONESIA BERDASARKAN ISLAMIC SOCIAL REPORTING INDEKS

    Directory of Open Access Journals (Sweden)

    Khusnul Fauziah

    2013-05-01

    Full Text Available Penelitian ini dilakukan untuk membandingkan pengungkapan tanggungjawab sosial bank syariah di Indonesia berdasarkan pada indeks Islamic Social Reporting (ISR. Obyek dari penelitian ini adalah tujuh bank syariah di Indonesia. Penelitian ini menggunakan laporan tahunan tahun 2011 yang dipublikasikan pada masing-masing bank. Analisis data menggunakan analisis isi. Hasil penelitian menunjukkan skore indek IRS tertinggi adalah Bank Muamalat Indonesia dengan skore 73% dan skore terendah adalah Bank Panin Syariah dengan skore 41%. This research is intended to compare the social responsibility disclosure of Islamic banking in Indonesia based on the Islamic Social Reporting (ISR index. The object of this research is taken from seven Islamic bankings in Indonesia. This research use the data from the annual report which was published in 2011 by the banks. The content analysis is implemented for analyzing the data. The results show that the highest score of social responsibility disclosure is Bank Muamalat Indonesia with the score of 73% and the lowest score is Panin Bank Syariah with the score of 41%.

  9. PENENTUAN WAKTU PERAWATAN UNTUK PENCEGAHANPADA KOMPONEN KRITIS CYCLONE FEED PUMP BERDASARKAN KRITERIA MINIMASI DOWN TIME

    Directory of Open Access Journals (Sweden)

    Siti Nandiroh

    2006-08-01

    Full Text Available Sistem perawatan mesin yang dilakukan di PT. Newmont Nusa Tenggara, selama ini masih bersifat korektif yaitu perawatan setelah terjadi kerusakan. Kerusakan komponen ini biasanya akan ditandai dengan ditemukannya produk yang dihasilkan tidak sedikit mengalami kecacatan. Peranan perawatan terhadap komponen-komponen Cyclone Feed Pump pada Process Departement - PT.Newmont Nusa Tenggara sangat penting artinya untuk mencegah terjadinya kecacatan produk masal dan mencegah terjadinya down time produksi. Dan perawatan yang paling baik digunakan adalah perawatan pencegahan sebelum terjadinya kerusakan (preventive maintenance. Mesin kritis adalah mesin yang mengalami frekwensi kerusakan terbesar dengan total downtime terbesar. Untuk penentuan mesin kritis ini, langkah pertama yang dilakukan adalah dengan mengukur lamanya waktu downtime produksi dari tiap-tiap mesin yang ada. Perhitungan MTTR berdasarkan data downtime, yang sebelumnya juga dilakukan uji kecocokan distribusi dan hasilnya sesuai, Dengan melakukan perhitungan Mean Time To Repair dan Mean Time To Failure dapat diketahui rata-rata waktu berapa lama pompa beroperasi dan berapa lama pompa tersebut dapat dilakukan perbaikan serta dapat diketahui Reliability pada Cyclone Feed Pump 2.0.1. Setelah dilakukkan perhitungan, komponen kritis Discharge Pipe pada Cyclone Feed Pump 2.0.1 harus sudah dilakukan inspeksi preventif, karena telah beroperasi 664.8 jam, dan perbaikan yang harus lakukan maksimal 3.4997 jam setiap kali dilakukan shutdown.

  10. Analysis of the ATR fuel element swaging process

    International Nuclear Information System (INIS)

    This report documents a detailed evaluation of the swaging process used to connect fuel plates to side plates in Advanced Test Reactor (ATR) fuel elements. The swaging is a mechanical process that begins with fitting a fuel plate into grooves in the side plates. Once a fuel plate is positioned, a lip on each of two side plate grooves is pressed into the fuel plate using swaging wheels to form the joints. Each connection must have a specified strength (measured in terms, of a pullout force capacity) to assure that these joints do not fail during reactor operation. The purpose of this study is to analyze the swaging process and associated procedural controls, and to provide recommendations to assure that the manufacturing process produces swaged connections that meet the minimum strength requirement. The current fuel element manufacturer, Babcock and Wilcox (B ampersand W) of Lynchburg, Virginia, follows established procedures that include quality inspections and process controls in swaging these connections. The procedures have been approved by Lockheed Martin Idaho Technologies and are designed to assure repeatability of the process and structural integrity of each joint. Prior to July 1994, ATR fuel elements were placed in the Hydraulic Test Facility (HTF) at the Idaho National Engineering Laboratory (AGNAIL), Test Reactor Area (TRA) for application of Boehmite (an aluminum oxide) film and for checking structural integrity before placement of the elements into the ATR. The results presented in this report demonstrate that the pullout strength of the swaged connections is assured by the current manufacturing process (with several recommended enhancements) without the need for- testing each element in the HTF

  11. Evaluating E-business in IT company : ATR Soft Oy

    OpenAIRE

    Franc, Eric

    2014-01-01

    The internet is now at an age where company can’t ignore having their products and services advertised on this channel. Internet is becoming a new way to gain and attract customers. The objective of this study is to evaluate if implementation of E-business could be viable for an IT software company. This study was commissioned by ATR Soft Oy and it begins with an overview of the company business model and product line. The theory section examines frameworks regarding E-business transforma...

  12. ATR-FTIR Studies on the Packing Film%一种包装膜的ATR-FTIR的剖析

    Institute of Scientific and Technical Information of China (English)

    孙瑞卿; 张汉辉; 杨融生

    2001-01-01

    FTIR and ATR-FTIR of the packing film have been studied.The dimension of thickness is about 0.034 m/m,the right and wrong sides of this packing film is composed of polypropylene and polyethylene glycol terephthalate, respectively.%在FTIR中,使用透射谱及水平ATR对进口的一种包装膜进行分析,该膜的厚度大约为0.034 m/m,膜的两面分别由等规聚丙烯和聚对苯二甲酸乙二醇酯组成。

  13. Diversitas Genetik Anopheles balabacensis, Baisas di Berbagai Daerah Indonesia Berdasarkan Sekuen Gen ITS 2 DNA Ribosom

    Directory of Open Access Journals (Sweden)

    Widiarti Widiarti

    2016-05-01

    dilaporkan sebagai spesies kompleks di berbagai negara, akan tetapi belum banyak dilaporkan di Indonesia. Penanggulangan malaria agar lebih efektif perlu adanya perbaikan dan pendekatan strategi dalam pengendalian vektor, termasuk sangat diperlukan adanya pemahaman terhadap spesies dan bioekologinya. Tujuan penelitian adalah untuk : a. Mengidentifikasi secara molekuler nyamuk An. balabacensis yang dicurigai sebagai spesies kompleks berdasarkan sekuen ITS2 DNA ribosom, b. Mengetahui diversitas genetik nyamuk An. balabacensis dari daerah endemis dan non endemis dengan jarak geografis yang berbeda, c. Mengetahui kekerabatan genetik (jarak taksonomi nyamuk An. balabacensis dari berbagai daerah di Indonesia dengan merekonstruksi pohon filogenetik. Hasil penelitian menunjukkan bahwa An. balabacensis di Indonesia merupakan spesies kompleks simpatrik dan allopatrik. Ada perbedaan kekerabatan genetikyang cukup jauh diantara populasi An. balabacensis di Pusuk Lestari, wilayah Puskesmas Meninting, Lombok Barat, NTB yang merupakan simpatrik kompleks. Berdasarkan hubungankekerabatan An. leucosphyrus group, An. balabacensis dari Berjoko, Kabupaten Nunukan menunjukkan kecenderungan terpisah cukup jauh dibandingkan dengan An. balabacensiskompleks lainnya yang berasal dari Jawa Tengah dan Lombok, NTB.Kata kunci : An. balabacensis, variasi genetik, ITS2 DNA ribosom

  14. STUDI POTENSI ENERGI GEOTHERMAL BLAWAN- IJEN, JAWA TIMUR BERDASARKAN METODE GRAVITY

    Directory of Open Access Journals (Sweden)

    Raehanayati Raehanayati

    2013-11-01

    Full Text Available Penelitian ini merupakan studi awal untuk menentukan daerah yang memiliki potensi   panasbumi   berdasarkan   pengukuran   gayaberat   di   Blawan-Ijen,   Jawa   Timur. Pengukuran data primer dilakukan dengan menggunakan Gravitimeter LaCoste & Romberg tipe G-1053. Data anomali Bouger dari hasil perhitungan koreksi-koreksi metode gayaberat kemudian dibawa ke bidang datar selanjutnya dilakukan pemisahan anomali regional dan anomali sisa dengan menggunakan metode kontinuasi ke  atas. Hasil interpretasi terhadap anomali sisa yang dilakukan pada tiga penampang adalah penampang A-A’ nilai densitasnya yaitu: ρ1=2.58 gr/cm3, ρ2=2.80 gr/cm3 , ρ3=2.67 gr/cm3, dan ρ4=2.69 gr/cm3, sedangkan untuk penampang B-B’ nilai densitasnya adalah ρ1=2.58 gr/cm3, ρ2=2.82 gr/cm3, ρ3=2.67 gr/cm3, dan untuk penampang C-C’  nilai  densitasnya yaitu  ρ1=2.585 gr/cm3,  ρ2=2.82 gr/cm3,  ρ3=2.67 gr/cm3 dan ρ4=2.684 gr/cm3. Dari hasil pemodelan 2D dan 3D dapat terlihat bahwa pada daerah yang memiliki manifestasi air panas didominasi oleh batuan ρ1 karena memiliki nilai densitas paling rendah yang berada pada daerah Blawan. Sehingga dapat disimpulkan bahwa reservoir panasbumi  daerah  Blawan-Ijen  didominasi  oleh  batuan  yang  memiliki  porositas  tinggi (densitas rendah dan tingkat permeabilitasnya tinggi dengan jumlah volume sebesar 101.20 juta m3.

  15. ATR-FTIR Spectroscopy in the Undergraduate Chemistry Laboratory: Part I--Fundamentals and Examples

    Science.gov (United States)

    Schuttlefield, Jennifer D.; Grassian, Vicki H.

    2008-01-01

    Attenuated total reflectance-Fourier transform infrared (ATR-FTIR) spectroscopy is a useful technique for measuring the infrared spectra of solids and liquids as well as probing adsorption on particle surfaces. Several examples of the use of FTIR-ATR spectroscopy in different undergraduate chemistry laboratory courses are presented here. These…

  16. An add-on system for photochemical ATR-IR spectroscopy studies

    DEFF Research Database (Denmark)

    2014-01-01

    ,300H,300J) to be attached to an ATR plate (200) to form a sample cavity (302) enclosing the sample (204). The cap (300G,300H,300J) comprises openings for allowing gas to enter and exit the sample cavity (304,306,308), cap sealing means (310) for providing a tight sealing between the ATR plate (200...

  17. Another Travesty of Representation: Phonological Representation and Phonetic Interpretation of ATR Harmony in Kalenjin.

    Science.gov (United States)

    Local, John; Lodge, Ken

    1996-01-01

    The Kalenjin group of languages, spoken mainly in western Kenya, displays a harmony system involving the phonological feature Advanced Tongue Root ([ATR]). The study reported here addresses issues of the phonological representation of the [ATR] in Kalenjin and its phonetic interpretation. Specifically, it is shown that (1) the harmony system…

  18. Mislocalization of the MRN complex prevents ATR signaling during adenovirus infection

    DEFF Research Database (Denmark)

    Carson, Christian T; Orazio, Nicole I; Lee, Darwin V;

    2009-01-01

    The protein kinases ataxia-telangiectasia mutated (ATM) and ATM-Rad3 related (ATR) are activated in response to DNA damage, genotoxic stress and virus infections. Here we show that during infection with wild-type adenovirus, ATR and its cofactors RPA32, ATRIP and TopBP1 accumulate at viral...

  19. ARF and ATM/ATR cooperate in p53-mediated apoptosis upon oncogenic stress

    International Nuclear Information System (INIS)

    Induction of apoptosis is pivotal for eliminating cells with damaged DNA or deregulated proliferation. We show that tumor suppressor ARF and ATM/ATR kinase pathways cooperate in the induction of apoptosis in response to elevated expression of c-myc, β-catenin or human papilloma virus E7 oncogenes. Overexpression of oncogenes leads to the formation of phosphorylated H2AX foci, induction of Rad51 protein levels and ATM/ATR-dependent phosphorylation of p53. Inhibition of ATM/ATR kinases abolishes both induction of Rad51 and phosphorylation of p53, and remarkably reduces the level of apoptosis induced by co-expression of oncogenes and ARF. However, the induction of apoptosis is downregulated in p53-/- cells and does not depend on activities of ATM/ATR kinases, indicating that efficient induction of apoptosis by oncogene activation depends on coordinated action of ARF and ATM/ATR pathways in the regulation of p53

  20. Corrosion inhibitor film formation studied by ATR-FTIR

    Energy Technology Data Exchange (ETDEWEB)

    Campbell, S.; Jovancicevic, V. [Baker Petrolite, Sugar Land, TX (United States)

    1999-11-01

    The development of an inhibitor film is essential for the effective performance of a corrosion inhibitor. The use of attenuated total reflection fourier transform infrared spectroscopy (ATR-FTIR) allows the development of inhibitor films on iron oxides to be monitored. For two distinct corrosion inhibitor chemistries, oleic imidazoline and phosphate ester, the film formation and corrosion processes are monitored on Fe{sub 3}O{sub 4} in a powdered form (a model surface). Additional data following on the physical and chemical properties are obtained using XPS and SEM techniques, which allows for a more complete characterization of the model inhibitor/oxide system. By the proper choice of system and measurement techniques, the complex phenomenon of corrosion inhibition may be analyzed directly.

  1. Thermal Analysis of Irradiation Experiments in the ATR

    Energy Technology Data Exchange (ETDEWEB)

    Paul Murray

    2012-09-01

    Reactor material testing in the INL's Advanced Test Reactor (ATR) involves modeling and simulation of each experiment to accurately determine the irradiation temperature. This paper describes thermal analysis of capsule experiments using gas gap temperature control and provides data on recent material tests that validate the modeling results. Static capsule experiments and lead-out capsule experiments are discussed. The source of temperature variation in capsule experiments and ways to mitigate these variations are also explained. Two examples of instrumented lead-out capsule experiments, TMIST-1 and UCSB-2, are presented. A comparison of measured and calculated temperatures is used to validate the thermal models and to ascertain the accuracy of the calculated temperature.

  2. Characterization and sintering of ATR aluminia from niobium

    International Nuclear Information System (INIS)

    The characterization of resultante slag from Aluminothermic Reduction (ATR) process to obtain metallic niobium is presented. The slag was characterized for concentration and phases of aluminia by X-ray diffractometry. The results show that 70% of the slag is constituted by α aluminia. The lixiviation and calcination of the slag increased the α aluminia concentration to 95%, the slag was used for producing samples to be burning in three furnaces: electrical resistance furnace in the air, and two furnaces in the vacuum. The burned samples were characterized by microscopy, ultrasonic analysis, density measurements and X-ray diffractometry. The sintering in the vacuum is possible because the samples burned in vacuum presented major density. The formation of NbO2 and mullite was observed, by X-ray diffractometry. The data from optical microscopy, density measurements and X-ray diffractometry show high porosity. (M.C.K.)

  3. Deep convolutional neural networks for ATR from SAR imagery

    Science.gov (United States)

    Morgan, David A. E.

    2015-05-01

    Deep architectures for classification and representation learning have recently attracted significant attention within academia and industry, with many impressive results across a diverse collection of problem sets. In this work we consider the specific application of Automatic Target Recognition (ATR) using Synthetic Aperture Radar (SAR) data from the MSTAR public release data set. The classification performance achieved using a Deep Convolutional Neural Network (CNN) on this data set was found to be competitive with existing methods considered to be state-of-the-art. Unlike most existing algorithms, this approach can learn discriminative feature sets directly from training data instead of requiring pre-specification or pre-selection by a human designer. We show how this property can be exploited to efficiently adapt an existing classifier to recognise a previously unseen target and discuss potential practical applications.

  4. Pengajaran Tentang Ibadah Berdasarkan Surat Ibrani 10:19-25 Dan Implimentasinya Dalam Kehidupan Orang Percaya Pada Masa Kini

    Directory of Open Access Journals (Sweden)

    Tison Tison

    2013-04-01

    Full Text Available Sesuai dengan permasalahan yang ada, maka tujuan penulisan karya ilmiah iniadalah: Pertama, Untuk menganalisis dan menafsirkan pengajaran tentang ibadahmenurut Ibrani 10:19-25. Kedua, Untuk membahas bagaimana mengimplementasikanpengajaran tentang ibadah dalam kehidupan orang percaya pada masa kini.Dalam penulisan karya ilmiah ini, penulis menggunakan metode penelitiannaskah Alkitab yaitu: Pertama, Metode analisis kitab, dalam hal ini menggunakanmetode penelitian yang mencakup teologi eksegesis dan kajian Alkitab untukmemahami teks yang sesuai dengan konsep yang ada dalam surat Ibrani 10:19-25. Danmenggunakan metode penelitian literatur. Kedua, Komparasi, yaitu mengadakanperbandingan-perbandingan untuk melihat kesamaan atau perbedaan pengajarantentang ibadah.Berdasarkan hasil uraian penulis dalam karya ilmiah mengenai pengajarantentang ibadah berdasarkan surat Ibrani 10:19-25 dan implimentasinya dalamkehidupan orang percaya pada masa kini, maka penulis dapat menarik kesimpulansebagai berikut: Pertama, setiap orang percaya harus mengerti dasar-dasar ibadahorang percaya yaitu darah Yesus yang telah dicurahkan bagi umat manusia yang jugatelah menjadi pengganti korban persembahan untuk datang menghampiri Allah danYesus sebagai Imam Besar. Kedua, dalam ibadah setiap orang percaya harusmemiliki sikap hati yang tulus iklhas, keyakinan iman, hati yang sudah dibasuh danberpegang pada pengakuan pengharapan pada Yesus. Ketiga, dalam ibadah, setiaporang percaya harus memiliki hati yang menyembah karena penyembahan adalah halyang paling utama untuk menyatakan hormat dan tunduk kepada Allah atas karya-Nya bagi hidup orang percaya. Keempat, dalam ibadah, setiap orang percaya harushidup dalam kekudusan, karena dalam kekudusanlah orang percaya layak dihadapanAllah.

  5. Mutation of serine 1333 in the ATR HEAT repeats creates a hyperactive kinase.

    Directory of Open Access Journals (Sweden)

    Jessica W Luzwick

    Full Text Available Subcellular localization, protein interactions, and post-translational modifications regulate the DNA damage response kinases ATR, ATM, and DNA-PK. During an analysis of putative ATR phosphorylation sites, we found that a single mutation at S1333 creates a hyperactive kinase. In vitro and in cells, mutation of S1333 to alanine (S1333A-ATR causes elevated levels of kinase activity with and without the addition of the protein activator TOPBP1. S1333 mutations to glycine, arginine, or lysine also create a hyperactive kinase, while mutation to aspartic acid decreases ATR activity. S1333A-ATR maintains the G2 checkpoint and promotes completion of DNA replication after transient exposure to replication stress but the less active kinase, S1333D-ATR, has modest defects in both of these functions. While we find no evidence that S1333 is phosphorylated in cultured cells, our data indicate that small changes in the HEAT repeats can have large effects on kinase activity. These mutants may serve as useful tools for future studies of the ATR pathway.

  6. RNF4 and PLK1 are required for replication fork collapse in ATR-deficient cells.

    Science.gov (United States)

    Ragland, Ryan L; Patel, Sima; Rivard, Rebecca S; Smith, Kevin; Peters, Ashley A; Bielinsky, Anja-Katrin; Brown, Eric J

    2013-10-15

    The ATR-CHK1 axis stabilizes stalled replication forks and prevents their collapse into DNA double-strand breaks (DSBs). Here, we show that fork collapse in Atr-deleted cells is mediated through the combined effects the sumo targeted E3-ubiquitin ligase RNF4 and activation of the AURKA-PLK1 pathway. As indicated previously, Atr-deleted cells exhibited a decreased ability to restart DNA replication following fork stalling in comparison with control cells. However, suppression of RNF4, AURKA, or PLK1 returned the reinitiation of replication in Atr-deleted cells to near wild-type levels. In RNF4-depleted cells, this rescue directly correlated with the persistence of sumoylation of chromatin-bound factors. Notably, RNF4 repression substantially suppressed the accumulation of DSBs in ATR-deficient cells, and this decrease in breaks was enhanced by concomitant inhibition of PLK1. DSBs resulting from ATR inhibition were also observed to be dependent on the endonuclease scaffold protein SLX4, suggesting that RNF4 and PLK1 either help activate the SLX4 complex or make DNA replication fork structures accessible for subsequent SLX4-dependent cleavage. Thus, replication fork collapse following ATR inhibition is a multistep process that disrupts replisome function and permits cleavage of the replication fork. PMID:24142876

  7. Proses Berpikir Siswa SD dalam Melakukan Estimasi Masalah Berhitung Berdasarkan Jenis Kelamin

    Directory of Open Access Journals (Sweden)

    Muh. Rizal

    2013-01-01

    Full Text Available Abstract: The Thinking Process of Primary-school Students of Different Sexes in Estimating Arithmetic Problems. This case study is intended to explore the thinking process of the fifth-year students of different sexes in estimating arithmetic problems. Two students, one male and one female, belonging to the high achievers in a mathematics test were selected for the study and then interviewed, assigned to solve arithmetic problems, and finally asked to think aloud their thinking process. The study reveals that the thinking process of both the male and female subjects is in the form of accommodation as they ap­proached the arithmetic problems by repeatedly reading the tasks. Though employing the same thinking process, in the planning stage, the male subject made use of rounding and compatible number strategies, whereas the female one used only rounding strategy. In implementing the plan, the male subject em­ployed mental counting through assimilation, but the female one used algorithm through accommoda­tion. In the evaluating stage, the male subject traced back his work through mental counting, while the female one utilized reverse operations. Abstrak: Proses Berpikir Siswa SD dalam Melakukan Estimasi Masalah Berhitung Berdasarkan Jenis Kelamin. Penelitian ini ingin mendeskripsikan proses berpikir siswa laki-laki dan perempuan yang berkemampuan matematika tinggi dalam melakukan estimasi. Penelitian dilakukan di kelas V SD, dengan subjek satu siswa laki-laki dan satu siswa perempuan yang memiliki skor 75 ke atas dalam tes kemampuan matematika. Data dikumpulkan dengan wawancara, pemberian tes dan think aloud. Analisis dilakukan dengan menelaah seluruh data, reduksi data, pengolompokan data, kategorisasi, pengkodean, dan pemeriksaan kredibilitas data dengan triangulasi waktu. Hasil penelitian menunjukkan bahwa proses berpikir keduanya adalah akomodasi. Dalam membuat rencana, laki-laki menggunakan rounding dan compatible number strategy, sedangkan

  8. Analisis Deskriptif Soal Geometri dalam Buku Matematika Bilingual untuk Sekolah Menengah Pertama Kelas VIII Berdasarkan Kriteria International Assessment TIMSS 2007

    Directory of Open Access Journals (Sweden)

    Etik Rahayu

    2012-06-01

    Full Text Available Tujuan penelitian ini adalah untuk mendeskripsikan  domain kognitif dan aspek kognitif (required behavior soal matematika dalam Buku Matematika Bilingual untuk Sekolah Menengah Pertama (SMP Kelas VIII berdasarkan kriteria International Assessment TIMSS 2007 dan proporsinya. Metode penelitian yang digunakan adalah deskriptif kualitatif, dengan subjek penelitian adalah soal geometri dalam Buku Matematika Bilingual SMP. yang berjudul “Mathematics for Junior High School Grade VIII 1st Semester” dan “Mathematics for Junior High School Grade VIII 2nd Semester” karangan karangan M. Cholik Adinawan dan Sugijono. Pengumpulan data menggunakan metode observasi dan wawancara tentang penggunaan buku matematika bilingual yang paling banyak digunakan di kota semarang. Pedoman analisis soal berdasarkan kriteria International Assessment TIMSS 2007, dengan validasi hasil oleh ahli. Hasil penelitian menunjukkan bahwa soal yang dianalisis memuat satu hingga tujuh aspek kognitif. Sebagian besar soal memuat 4 aspek kognitif yaitu 44.04 %, diikuti soal dengan 3 aspek kognitif  yaitu 36, 42%,  soal dengan 2 aspek kognitif yaitu 14, 90%, kemudian 1,99% untuk soal dengan 1 atau 5 aspek kognitif, dan 0,33% untuk soal dengan 6 atau 7 aspek kognitif. Proporsi tinggi pada recall (28.26% dan compute (26.57%, diikuti dengan SRP (10.85%, implement (10.65%, retrieve (8.36%, recognize (6.17%, analyze (1.99%, measure (1.59%, generalize (1.09%, SNRP (1.00%, classify (0.80%, represent (0.80%, justify (0.80%, select (0.60%, model (0.30%, synthesis (0.20%. Secara keseluruhan berdasarkan International Assessment TIMSS 2007 soal yang termasuk domain knowing memiliki persentase paling tinggi (52.28%, domain knowing-applying (24.83%, domain knowing- reasoning (12.91%, dan hanya sedikit yang termasuk domain knowing-apllying-reasoning (3.97%. Serta terdapat 4 soal (1.32% yang mempunyai ketidaksesuaian penggunaan mathematics terms serta 1 soal (0

  9. ANALISIS TERHADAP PERLUNYA PENYESUAIAN LAPORAN KEUANGAN HISTORIS (CONVENTIONAL ACCOUNTING MENJADI BERDASARKAN TINGKAT HARGA UMUM (GENERAL PRICE LEVEL ACCOUNTING

    Directory of Open Access Journals (Sweden)

    Pwee Leng

    2002-01-01

    Full Text Available Generally, in conventional accounting, financial statements are based on the historical cost principle that assumes that prices (monetery unit are stable. Conventional accounting recognizes neither changes in the general price level nor changes in the specific price level. Consequently, if there are any changes in purchasing power such as in inflation period, the historical financial statement are not economically relevant and also income is usually overstated, and the fixed assets are usually understated. Actually, there are several methods on accounting for the effect of changing prices, such as constant accounting, current value accounting, and general price level accounting. General price level accounting will do restatement the components of financial statement to be a rupiah on a similar level of purchasing power, but without changes in accounting principles which using on conventional accounting. In practice, the controversy concerning the relevance of general price level accounting has been continuing. Pros and cons general price level accounting will be presented on this paper. Also the result of two researches concerning the influence of applied general price level accounting on the financial statement will be compared as considerations whether the general price level adjustment is necessary needed. Abstract in Bahasa Indonesia : Secara umum, dalam akuntansi konvensional, laporan keuangan disajikan berdasarkan nilai historis yang mengasumsikan bahwa harga-harga (unit moneter adalah stabil. Akuntansi konvensional tidak mengakui adanya perubahan tingkat harga umum maupun perubahan tingkat harga khusus. Sebagai konsekuensinya, jika terjadi perubahan daya beli seperti pada periode inflasi, maka laporan keuangan historis secara ekonomis tidaklah relevan. Pada periode ini pendapatan umumnya dinilai lebih tinggi sedangkan aktiva tetap dinilai lebih rendah. Sebenarnya, terdapat beberapa metode akuntansi mengenai pengaruh perubahan harga

  10. 皮革产品的ATR-FTIR快速鉴定%High-Speed Examination of Leather Products by ATR-FTIR

    Institute of Scientific and Technical Information of China (English)

    张红雨; 徐琳; 王乃岩

    2004-01-01

    分析和比较真皮和人造革的ATR-FTIR红外谱图表明,两者的特征峰峰位并不重叠或干扰,其结构可以区分.用ATR-FTIR鉴定皮革产品具有准确、灵敏、快速、简便、对产品无损伤、无需预处理、易实现现场自动化等优点.

  11. Neutron dosimetry and damage calculations for the ATR-A1 irradiation

    Energy Technology Data Exchange (ETDEWEB)

    Greenwood, L.R.; Ratner, R.T. [Pacific Northwest National Lab., Richland, WA (United States)

    1998-09-01

    Neutron fluence measurements and radiation damage calculations are reported for the collaborative US/Japan ATR-A1 irradiation in the Advanced Test Reactor (ATR) at Idaho National Engineering Laboratory (INEL). The maximum total neutron fluence at midplane was 9.4 {times} 10{sup 21} n/cm{sup 2} (5.5 {times} 10{sup 21} n/cm{sup 2} above 0.1 MeV), resulting in about 4.6 dpa in vanadium.

  12. Interaction between PARP-1 and ATR in mouse fibroblasts is blocked by PARP inhibition

    OpenAIRE

    Kedar, Padmini S.; Stefanick, Donna F.; Horton, Julie K.; Wilson, Samuel H.

    2008-01-01

    Inhibition of PARP activity results in extreme sensitization to MMS-induced cell killing in cultured mouse fibroblasts. In these MMS-treated cells, PARP inhibition is accompanied by an accumulation of S-phase cells that requires signaling by the checkpoint kinase ATR (Horton et al. (2005) J. Biol. Chem., 280, 15773-15785). Here, we examined mouse fibroblast extracts for formation of a complex that may reflect association between the damage responsive proteins PARP-1 and ATR. Co-immunoprecipit...

  13. Analisis Keanekaragaman Genetika dan Diferensiasi Jati Jawa dan Madura Berdasarkan Marka Mikrosatelit Untuk Mendukung Fingerprinting Jati

    Directory of Open Access Journals (Sweden)

    Mun Isyatul Millah

    2012-09-01

    Full Text Available Fingerprinting jati diperlukan untuk melengkapi data base konservasi plasma nutfah jati. Penelitian ini bertujuan untuk mendapatkan informasi keanekaragaman genetika pohon jati berdasarkan marka mikrosatelit dan mengidentifikasi alel spesifik pada lokus tertentu yang dapat menjadi penciri khas jati populasi Jawa dan Madura. Pada penelitian ini dilakukan identifikasi karakteristik jati plus (fingerprinting secara molekuler menggunakan penanda mikrosatelit. Sampel diambil dari koleksi jati plus di Kebun Benih Klonal (KBK di Jawa dan dari lokal Areal Produksi Benih (APB Madura. Sampel diisolasi menggunakan metode CTAB. Amplifikasi DNA menggunakan 3 primer mikrosatelit dan hasilnya divisualisasi pada gel poliakrilamid dengan pewarnaan silver. Hubungan kekerabatan dianalisis melalui program NTSYSpc (Numerical Taxonomy and Multivariate Analysis Sistem versi 2.01. Hasil analisis menunjukkan tingkat keanekaragaman jati yang tinggi, didukung oleh nilai Observed Heterozigosity (Ho, Expected Heterozygosity (He, Polimorfism Information Content (PIC dan koefisien diferensiasi genetika berturut-turut 0.5122; 0.6221; 0.5818; dan 0.0629. Hubungan kekerabatan melalui analisis dendogram menghasilkan koefisien kemiripan 0.3-1.00. Nilai keanekaragaman dalam populasi (HS, antar populasi (DST, dan nilai diferensiasi (G berturut-turut adalah 0.5817, 0.0391, dan 0.0629. Dari hasil analisis disimpulkan bahwa tingkat keanekaragaman jati di Jawa dan Madura termasuk tinggi dan ada indikasi perbedaan genetika di dalam populasi lebih tinggi dibanding antar populasi.Fingerprinting teak is required to complete the data base teak germplasm conservation. This research aimed to obtain information about the genetic diversity of teak based on microsatellite markers and identify specific allele at a particular locus can be distinctive identity identifier population of Java and Madura. In this research is to identify the characteristics of teak plus (fingerprinting molecularly using

  14. Gambaran Slide Malaria Berdasarkan Sediaan Darah dari Kepulauan Siberut Mentawai Periode Oktober 2011 – Januari 2012

    Directory of Open Access Journals (Sweden)

    Adeline Sacharissa Firdaus

    2014-05-01

    Full Text Available AbstrakMalaria adalah penyakit penting yang saat ini telah menjadi masalah kesehatan dunia dan endemik di 105 negara salah satunya Indonesia. Indonesia memiliki banyak kepulauan yang tersebar salah satunya yaitu Kepulauan Mentawai. Kepulauan Mentawai merupakan daerah endemi malaria yang terdiri atas 4 pulau salah satunya yaitu Kepulauan Siberut Mentawai. Tujuan dari penelitian ini adalah untuk mengetahui Insiden kejadian malaria di Kepulauan Siberut Mentawai periode Oktober 2012 – Januari 2012. Desain penelitian yaitu deskriptif dan observational. Sediaan darah yang berasal dari Puskesmas Muara Siberut Kepulauan Siberut Mentawai dikirim ke Laboratorium Parasitologi Fakultas Kedokteran Universitas Andalas untuk diperiksa. Penelitian dilakukan dengan cara pemeriksaan secara mikroskopik sediaan darah tebal dan tipis dari sampel darah tepi yang telah dipulas dengan pewarnaan Giemsa untuk mengetahui berapa insiden kejadian malaria, distribusi malaria menurut jenis kelamin, distribusi malaria menurut jenis plasmodium dan Parasite Count. Seluruh Sediaan darah berjumlah 106 sediaan darah dan 32 diantaranya positif malaria. Berdasarkan jenis kelamin ditemukan pada perempuan 17 sediaan darah dan laki-laki sebanyak 15 sediaan darah. jenis Plasmodium yang ditemukan adalah Plasmodium falciparum sebanyak 20 sediaan darah dan Plasmodium vivax sebanyak 12 sediaan darah. Menurut parasite count 14 sediaan darah diantaranya merupakan infeksi ringan dan 6 sediaan darah lainnya merupakan infeksi berat. Kesimpulan penelitian ini adalah (1 kejadian positif malaria ditemukan sebanyak 30,2%, (2 Insiden kejadian malaria lebih tinggi pada perempuan dibandingkan laki-laki, (3 Hanya ditemukan jenis Plasmodium falciparum dan Plasmodium vivax pada penelitian, (4 Derajat infeksi ringan kejadiannya lebih tinggi dibandingkan infeksi berat.Kata kunci: Malaria, Plasmodium falciparum, Plasmodium vivax, Parasit countAbstractMalaria is an important disease that has become a global

  15. Cancer-Specific Synthetic Lethality between ATR and CHK1 Kinase Activities

    Directory of Open Access Journals (Sweden)

    Kumar Sanjiv

    2016-01-01

    Full Text Available ATR and CHK1 maintain cancer cell survival under replication stress and inhibitors of both kinases are currently undergoing clinical trials. As ATR activity is increased after CHK1 inhibition, we hypothesized that this may indicate an increased reliance on ATR for survival. Indeed, we observe that replication stress induced by the CHK1 inhibitor AZD7762 results in replication catastrophe and apoptosis, when combined with the ATR inhibitor VE-821 specifically in cancer cells. Combined treatment with ATR and CHK1 inhibitors leads to replication fork arrest, ssDNA accumulation, replication collapse, and synergistic cell death in cancer cells in vitro and in vivo. Inhibition of CDK reversed replication stress and synthetic lethality, demonstrating that regulation of origin firing by ATR and CHK1 explains the synthetic lethality. In conclusion, this study exemplifies cancer-specific synthetic lethality between two proteins in the same pathway and raises the prospect of combining ATR and CHK1 inhibitors as promising cancer therapy.

  16. Analisis Isi SMS Iklan Layanan Telekomunikasi Operator Telkomsel, Indosat dan Xl berdasarkan Etika Pariwara Indonesia Periode 2013

    Directory of Open Access Journals (Sweden)

    Danang Trijayanto

    2014-09-01

    Full Text Available Perkembangan teknologi komunikasi merevolusi aktivitas pemasaran ke mobile marketing, salah satunya adalah dengan SMS advertising. Badan usaha yang cenderung menggunakan cara pemasaran tersebut adalah operator selular dengan iklan produk layanan telekomunikasinya. Permasalahannya adalah strategi pemasaran produk telekomunikasi yang cenderung banyak merugikan pelanggan karena ketidaksesuaian antara isi iklan dan produk yang diperoleh, yang dipengaruhi oleh kelengkapan dan kejelasan informasi produk. Salah satu aturan yang menjadi dasar dalam aktivitas SMS advertising adalah berdasarkan Etika Pariwara Indonesia.  Penelitian  ini   meneliti  bagaimanakah  Penerapan aturan tersebut terhadap isi SMS iklan produk telekomunikasi yang dikirimkan oleh provider selular GSM prabayar pada bulan Juli hingga Nopember 2013.  Hasil  Penelitian menunjukkan bahwa dalam mengiklankan produk telekomunikasi melalui SMS advertising, para operator selular belum menerapkan regulasi dan etika pemasaran dengan baik. Kekurangan informasi yang belum lengkap terdapat pada informasi syarat kontrak yang menjadi informasi dasar hak dan kewajiban yang harus dipenuhi oleh pelanggan.

  17. TopBP1和ATR-ATRIP在细胞周期中的作用及联系%Role and Relationship of TopBP1 and ATR-ATRIP in the Cell Life Cycle

    Institute of Scientific and Technical Information of China (English)

    黄神安; 熊高飞; 张吉翔

    2006-01-01

    TopBP1(topoisomerase Ⅱ beta-binding protein 1)和ATR(ataxia-telangiectasia mutated-and rad3-related)-ATRIP(ATR-interacting protein)通过调节一些因子在DNA损伤检控点(DNA damage checkpoint)中起着关键的作用,其中TopBP1可以激活ATR-ATRIP的复合体.文章着重阐述了TopBP1和ATR-ATRIP如何调控细胞周期并发挥其维护基因组完整性的作用.

  18. Evaluasi Komponen Jalan Rel Berdasarkan Passing Tonnage dan Analisis Kebutuhan Pemeliharaan Tahunan Jalan Rel dengan Analisa JO Tahun 2011 (Studi Kasus Jalan Rel Lintas Medan – Tebing Tinggi)

    OpenAIRE

    Panjaitan, Herbet

    2014-01-01

    Jalan rel yang menghubungkan Medan – Tebing Tinggi merupakan lintasan jalan rel sepanjang 80,542 kilometer yang dilewati 40 kereta api setiap harinya, sehingga akan menurunkan kualitas pelayanan komponen jalan rel kereta api. Evaluasi komponen rel terpasang pada jalan rel kereta api dilakukan dengan menghitung daya angkut lintas jalan rel untuk satu tahun, kemudian membandingkan komponen jalan rel terpasang berdasarkan standar perencanaan jalan rel sesuai dengan klasifikasi kelas jalan r...

  19. Feature-based ATR performance method for FLIR

    Science.gov (United States)

    Doria, David M.

    2004-09-01

    A performance model for FLIR automatic target recognition is discussed. Key aspects of this model are that (a) relationships between sensor optical resolution, sampling, noise and estimated P(ID) are implicitly defined, (b) premised on the use of the particular features that are used, the analysis of the matching structure leads to an explicit "shape similarity" measure between targets, (c) the notion of "shape" includes both internal signature attributes and external contour information; (d) the values of this shape measure can be measured for both true and false target models using combined CAD rendering, sensor models, and features, (e) in addition to the P(ID), the system also is able to predict the probability of declaration P(Declare|Target) for a given true target, (f) the system is able to predict the probability of false declaration for a given confuser or confuser to target similarity specification, (g) M (with M greater than or equal to 2) class problems are able to be handled, and (h) the diagonals along confusion matrices can be estimated directly using this approach. The model relies on analysis of performance of a particular type of shape-based features, with the goal of developing explicit relationships from low level features through high level model matching. Based on the predicted densities of the ensemble of features, the system approximates an expression for the likelihood of the observed features under noisy conditions with a given sensor, conditioned on the target type, aspect, and range. Using some engineering approximations that relate to the distance transform-type method of matching that is analyzed, a tractable form of a non-unique correspondence based approximate likelihood expression is obtained, which can be used to estimate bounds on the performance of similar sensor/ATR systems that rely on these features. Such an approach could also be applied to other phenomenologies, such as synthetic aperture radar, using an appropriate low

  20. ATR suppresses endogenous DNA damage and allows completion of homologous recombination repair.

    Science.gov (United States)

    Brown, Adam D; Sager, Brian W; Gorthi, Aparna; Tonapi, Sonal S; Brown, Eric J; Bishop, Alexander J R

    2014-01-01

    DNA replication fork stalling or collapse that arises from endogenous damage poses a serious threat to genome stability, but cells invoke an intricate signaling cascade referred to as the DNA damage response (DDR) to prevent such damage. The gene product ataxia telangiectasia and Rad3-related (ATR) responds primarily to replication stress by regulating cell cycle checkpoint control, yet it's role in DNA repair, particularly homologous recombination (HR), remains unclear. This is of particular interest since HR is one way in which replication restart can occur in the presence of a stalled or collapsed fork. Hypomorphic mutations in human ATR cause the rare autosomal-recessive disease Seckel syndrome, and complete loss of Atr in mice leads to embryonic lethality. We recently adapted the in vivo murine pink-eyed unstable (pun) assay for measuring HR frequency to be able to investigate the role of essential genes on HR using a conditional Cre/loxP system. Our system allows for the unique opportunity to test the effect of ATR loss on HR in somatic cells under physiological conditions. Using this system, we provide evidence that retinal pigment epithelium (RPE) cells lacking ATR have decreased density with abnormal morphology, a decreased frequency of HR and an increased level of chromosomal damage. PMID:24675793

  1. In-situ ATR-FTIR for characterization of thin biorelated polymer films

    Energy Technology Data Exchange (ETDEWEB)

    Müller, M., E-mail: mamuller@ipfdd.de [Leibniz Institute of Polymer Research Dresden (IPF Dresden), Hohe Straße 6, 01069 Dresden (Germany); Technical University of Dresden (TUD), Department of Chemistry and Food Chemistry, 01062 Dresden (Germany); Torger, B. [Leibniz Institute of Polymer Research Dresden (IPF Dresden), Hohe Straße 6, 01069 Dresden (Germany); Technical University of Dresden (TUD), Department of Chemistry and Food Chemistry, 01062 Dresden (Germany); Bittrich, E. [Leibniz Institute of Polymer Research Dresden (IPF Dresden), Hohe Straße 6, 01069 Dresden (Germany); Kaul, E.; Ionov, L. [Leibniz Institute of Polymer Research Dresden (IPF Dresden), Hohe Straße 6, 01069 Dresden (Germany); Technical University of Dresden (TUD), Department of Chemistry and Food Chemistry, 01062 Dresden (Germany); Uhlmann, P. [Leibniz Institute of Polymer Research Dresden (IPF Dresden), Hohe Straße 6, 01069 Dresden (Germany); Stamm, M. [Leibniz Institute of Polymer Research Dresden (IPF Dresden), Hohe Straße 6, 01069 Dresden (Germany); Technical University of Dresden (TUD), Department of Chemistry and Food Chemistry, 01062 Dresden (Germany)

    2014-04-01

    We present and review in-situ-attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopic data from thin biorelated polymer films useful for the modification and functionalization of polymer and inorganic materials and discuss their applications related to life sciences. A special ATR mirror attachment operated by the single-beam-sample-reference (SBSR) concept and housing a homebuilt thermostatable flow cell was used, which allows for appropriate background compensation and signal to noise ratio. ATR-FTIR data on the reactive deposition of dopamine on inorganic model surfaces are shown. Information on the structure and deposition pathway for such bioinspired melanin-like films is provided. ATR-FTIR data on thermosensitive polymer brushes of poly(N-isopropylacrylamide) (PNIPAAM) is then presented. The thermotropic hydration and hydrogen bonding behavior of PNIPAAM brush films is described. Finally, ATR-FTIR data on biorelated polyelectrolyte multilayers (PEM) are given together with details on PEM growth and detection. Applications of these latter films for biopassivation/activation and local drug delivery are addressed.

  2. Involvement of ATM/ATR-p38 MAPK cascade in MNNG induced G1-S arrest

    Institute of Scientific and Technical Information of China (English)

    Ke-Qing Zhu; Suo-Jiang Zhang

    2003-01-01

    AIM: To understand the effect of low concentration of Nmethyl-N′-nitro-nitrosoguanidine (MNNG), which is a widely distributed environmental mutagen and carcinogen especially for human gastric cancer, on DNA damage and to study its possible pathway in regulating cell cycle arrest.METHODS: The DNA damage effect was measured by Comet assay. A specific phospho-(Ser/Thr) ATM/ATR substrate antibody was used to detect the damage sensor by Western blot. p38 kinase activity was measured by direct kinase assay,and immunoprecipitation for the possible connection between ATM/ATR and p38 MAPK. Flow cytometry analysis and p38MAPK specific inhibitor SB203580 were combined to detect the possible cell cycle arrest by p38 MAPK.RESULTS: With the same low concentration MNNG exposure (0.2μM 2.5 h), Comet assays indicated that strand breaks accumulated, Western blot and kinase assay showed ATM/ATR and p38 kinase activated, immunoprecipitation showed phospho-ATM/ATR substrate antibody combined with both p38 MAPK antibody and phospho-p38 MAPK antibody, p38MAPK pathway was involved in the G1-S arrest.CONCLUSION: Activation of ATM/ATR by MNNG induced DNA damage leads to activation of p38 MAPK, which involves in the G1 checkpoint in mammalian cells.

  3. Evaluation of shooting distance by AFM and FTIR/ATR analysis of GSR.

    Science.gov (United States)

    Mou, Yongyan; Lakadwar, Jyoti; Rabalais, J Wayne

    2008-11-01

    The techniques of atomic force microscopy (AFM) and Fourier transform infrared attenuated total reflectance (FTIR/ATR) spectroscopy are applied to the analysis of gun-shot residue (GSR) to test their ability to determine shooting distance and discrimination of the powder manufacturers. AFM is a nondestructive technique that is capable of characterizing the shapes and size distributions of GSR particles with resolution down to less than a nanometer. This may be useful for estimation of the shooting distance. Our AFM images of GSR show that the size distribution of the particles is inversely proportional to the shooting distance. Discrimination of powder manufacturers is tested by FTIR/ATR investigation of GSR. Identifying the specific compounds in the GSR by FTIR/ATR was not possible because it is a mixture of the debris of several compounds that compose the residue. However, it is shown that the GSR from different cartridges has characteristic FTIR/ATR bands that may be useful in differentiating the powder manufacturers. It appears promising that the development of AFM and FTIR/ATR databases for various powder manufacturers may be useful in analysis and identification of GSR. PMID:18761553

  4. Identifikasi Carrier Bakteri Streptococcus β hemolyticus Group A pada Murid SD Negeri 13 Padang Berdasarkan Perbedaan Umur dan Jenis Kelamin

    Directory of Open Access Journals (Sweden)

    Fadhila Aini

    2016-01-01

    Full Text Available AbstrakStreptococcus β hemolyticus Grup A atau yang disebut juga Streptococcus pyogenes merupakan salah satu bakteri patogen yang banyak menginfeksi manusia.Bakteri ini dapat ditemukan sebagai carrier di saluran pernafasan terutama pada anak-anak, tidak menimbulkan penyakit tetapi berisiko untuk menyebarkan penyakit. Tujuan penelitian ini adalah menentukan jumlah carrier  bakteri Streptococcus β hemolyticus Grup A pada murid berdasarkan perbedaan umur dan jenis kelamin. Jenis penelitian ini adalah deskriptif cross-sectional dengan menggunakan sampel seluruh murid SD Negeri 13 Padang. Hasil penelitian adalah didapatkan 2 orang murid yang menderita carrier, yaitu pada kelompok usia>8-9 tahun dan >11 tahun. Berdasarkan jenis kelamin yang terdiri dari 54 orang laki-laki dan 50 orang perempuan, didapatkan 2 orang carrier yaitu hanya pada anak laki-laki. Hasil penelitian menunjukkan bahwa carrier bakteri Streptococcus β hemolyticus Group  A terdapat pada anak usia tersebut karena masih kurangnya pengetahuan tentang kebersihan. Carrier yang ditemukan hanya pada anak laki-laki kemungkinan disebabkan mereka lebih sering bermain di luar rumah dan terpapar dengan berbagai bakteri patogen dan kurang memperhatikan kebersihan diri.Kata kunci: carrier, streptococcus β hemolyticus grup A, umur, jenis kelamin AbstractGroup A Streptococcus β hemolyticus or also called Streptococcus pyogenes is one of many pathogenic bacteria that infect humans. These bacteria can be found as a carrier in the respiratory tract especially in children, do not cause disease but can be a risk for spreading the disease. This objective of this study was to determine the amount of the carrier of bacteria group A Streptococcus β hemolyticus based on age and gender differences. This research is a descriptive cross - sectional study using a sample of all students of SD Negeri 13 Padang. Based on the age of 104 students found that students who suffer 2 carrier, which is in the age

  5. Hubungan Keteraturan Penggunaan Kortikosteroid Inhalasi dengan Tingkat Kontrol Asma Pasien Berdasarkan ACT di Poliklinik Paru RSUP Dr. M. Djamil Padang

    Directory of Open Access Journals (Sweden)

    Wulan Prisilla Prisilla

    2016-01-01

    Full Text Available AbstrakAsma merupakan penyakit yang didasari oleh reaksi inflamasi pada saluran napas yang dapat dicegah dengan kortikosteroid inhalasi. Asma sukar disembuhkan, sehingga tujuan penatalaksanaan asma adalah asma terkontrol. Penilaian tingkat kontrol asma dapat dilakukan dengan menggunakan kuesioner Asthma Control Test  (ACT yang bersifat subjektif tetapi validitasnya telah diuji. Tujuan penelitian ini adalah menentukan hubungan keteraturan penggunaan kortikosteroid inhalasi dengan tingkat kontrol asma pasien berdasarkan ACT di Poliklinik Paru RSUP Dr. M. Djamil Padang. Penelitian cross sectional analytic ini telah dilakukan dari September hingga Desember 2013. Populasi adalah pasien berusia ≥14 tahun yang didiagnosis asma oleh dokter. Jumlah subjek penelitian sebanyak 96 orang. Data yang diperoleh diolah dan dianalisis menggunakan uji Kolmogorov-Smirnov. Insiden terbanyak asma berada pada kelompok usia lanjut (60,4%. Sebagian besar pasien tidak teratur menggunakan kortikosteroid inhalasi (63,5% dan pasien dengan asma tidak terkontrol memiliki proporsi tertinggi (59,4% . Analisis statistik menunjukkan bahwa terdapat hubungan yang bermakna antara keteraturan penggunaan kortikosteroid inhalasi dengan tingkat kontrol asma pasien berdasarkan ACT di Poliklinik Paru RSUP Dr. M. Djamil (p=0,002.Kata kunci: kortikosteroid inhalasi, ACT, tingkat control asma AbstractAsthma is a disease caused by an inflammatory reaction in the patient airways that can be prevented with inhaled corticosteroids. It is known that there is no cure for asthma, so the goal of asthma management is to obtain controlled asthma. The level of asthma control can be assessed by  using Asthma Control Test  (ACT questionnaire, this method is subjective but its validity has been tested. The objective of this study  was to determine the association between regularity of inhaled corticosteroids application and patient’s level of asthma control based on ACT in the Lung Clinic of Dr

  6. Modeling the attenuated total reflectance infrared (ATR-FTIR) spectrum of apatite

    Science.gov (United States)

    Aufort, Julie; Ségalen, Loïc; Gervais, Christel; Brouder, Christian; Balan, Etienne

    2016-06-01

    Attenuated total reflectance (ATR) infrared spectra were measured on a synthetic and a natural fluorapatite sample. A modeling approach based on the computation of the Fresnel reflection coefficient between the ATR crystal and the powder sample was used to analyze the line shape of the spectra. The dielectric properties of the samples were related to those of pure fluorapatite using an effective medium approach, based on Maxwell-Garnett and Bruggeman models. The Bruggeman effective medium model leads to a very good agreement with the experimental data recorded on the synthetic fluorapatite sample. The poorer agreement observed on the natural sample suggests a more significant heterogeneity of the sample at a characteristic length scale larger than the mid-infrared characteristic wavelength, i.e., about 10 micrometers. The results demonstrate the prominent role of macroscopic electrostatic effects over fine details of the microscopic structure in determining the line shape of strong ATR bands.

  7. 10 CFR 830 Major Modification Determination for Replacement of ATR Primary Coolant Pumps and Motors

    Energy Technology Data Exchange (ETDEWEB)

    Noel Duckwitz

    2011-05-01

    The continued safe and reliable operation of the ATR is critical to the Department of Energy (DOE) Office of Nuclear Energy (NE) mission. While ATR is safely fulfilling current mission requirements, a variety of aging and obsolescence issues challenge ATR engineering and maintenance personnel’s capability to sustain ATR over the long term. First documented in a series of independent assessments, beginning with an OA Environmental Safety and Health Assessment conducted in 2003, the issues were validated in a detailed Material Condition Assessment (MCA) conducted as a part of the ATR Life Extension Program in 2007.Accordingly, near term replacement of aging and obsolescent original ATR equipment has become important to ensure ATR capability in support of NE’s long term national missions. To that end, a mission needs statement has been prepared for a non-major system acquisition which is comprised of three interdependent subprojects. The first project will replace the existent diesel-electrical bus (E-3), switchgear, and the 50-year-old obsolescent marine diesels with commercial power that is backed with safety related emergency diesel generators, switchgear, and uninterruptible power supply (UPS). The second project, the subject of this major modification determination, will replace the four, obsolete, original primary coolant pumps (PCPs) and motors. Completion of this and the two other age-related projects (replacement of the ATR diesel bus [E-3] and switchgear and replacement of the existent emergency firewater injection system) will resolve major age-related operational issues plus make a significant contribution in sustaining the ATR safety and reliability profile. The major modification criteria evaluation of the project pre-conceptual design identified several issues that lead to the conclusion that the project is a major modification: 1. Evaluation Criteria #3 (Change of existing process). The proposed strategy for equipping the replacement PCPs with VFDs

  8. Status of ATR-A1 irradiation experiment on vanadium alloys and low-activation steels

    Energy Technology Data Exchange (ETDEWEB)

    Tsai, H.; Strain, R.V.; Gomes, I.; Smith, D.L. [Argonne National Lab., IL (United States); Matsui, H. [Tohoku Univ. (Japan)

    1996-10-01

    The ATR-A1 irradiation experiment was a collaborative U.S./Japan effort to study at low temperature the effects of neutron damage on vanadium alloys. The experiment also contained a limited quantity of low-activation ferritic steel specimens from Japan as part of the collaboration agreement. The irradiation started in the Advanced Test Reactor (ATR) on November 30, 1995, and ended as planned on May 5, 1996. Total exposure was 132.9 effective full power days (EFPDs) and estimated neutron damage in the vanadium was 4.7 dpa. The vehicle has been discharged from the ATR core and is scheduled to be disassembled in the next reporting period.

  9. 粉煤灰激活中ATR/FTIR、FTIR和NMR的分析与比较

    Institute of Scientific and Technical Information of China (English)

    易志慧; 蒋海青; 王晓钧; 于士刚

    2007-01-01

    采用ATR/FTIR对南京热电厂Ⅰ级粉煤灰及经过NaOH激发后的样品进行了分析,并且同FTIR和NMR的分析结果进行比较。研究结果表明:以表征表面特征的ATR/FTIR方法可以清晰地表征粉煤灰表面出现的变化,且随着碱浓度的提高变化明显,而以表征宏观几率特征的FTIR和NMR则没有反映出粉煤灰表面出现的变化。ATR/FTIR在粉煤灰的表面研究中具有独到效果。

  10. Attenuated total reflection Fourier-transform infrared (ATR-FTIR) imaging of tissues and live cells.

    Science.gov (United States)

    Andrew Chan, K L; Kazarian, Sergei G

    2016-03-29

    FTIR spectroscopic imaging is a label-free, non-destructive and chemically specific technique that can be utilised to study a wide range of biomedical applications such as imaging of biopsy tissues, fixed cells and live cells, including cancer cells. In particular, the use of FTIR imaging in attenuated total reflection (ATR) mode has attracted much attention because of the small, but well controlled, depth of penetration and corresponding path length of infrared light into the sample. This has enabled the study of samples containing large amounts of water, as well as achieving an increased spatial resolution provided by the high refractive index of the micro-ATR element. This review is focused on discussing the recent developments in FTIR spectroscopic imaging, particularly in ATR sampling mode, and its applications in the biomedical science field as well as discussing the future opportunities possible as the imaging technology continues to advance. PMID:26488803

  11. Esophago-gastric motility and nutritional management in a child with ATR-X syndrome.

    Science.gov (United States)

    Watanabe, Toshihiko; Arai, Katsuhiro; Takahashi, Masataka; Ohno, Michinobu; Sato, Kaori; Fuchimoto, Yasushi; Wada, Takahiko; Ida, Shinobu; Kawahara, Hisayoshi; Kanamori, Yutaka

    2014-08-01

    X-linked alpha thalassemia mental retardation (ATR-X) syndrome is an X-linked recessive disorder that often involves gastrointestinal symptoms. Aspiration pneumonia related to gastroesophageal reflux has been reported as the major cause of death, but gastrointestinal function has not been well investigated. The present report describes a child with ATR-X syndrome who suffered from periodical episodes of refractory vomiting. We investigated the function of upper alimentary tract and found that esophago-gastric dysmotility and severe gastric volvulus were the major causes of gastrointestinal symptoms. This child was surgically treated with anterior gastropexy and jejunal alimentation through gastrostomy, and the symptoms were relieved with good weight gain. This report may provide insight into the gastrointestinal function and nutritional management in children with ATR-X syndrome. PMID:25252072

  12. Measured Thermal and Fast Neutron Fluence Rates for ATF-1 Holders During ATR Cycle 157D

    Energy Technology Data Exchange (ETDEWEB)

    Smith, Larry Don [Idaho National Lab. (INL), Idaho Falls, ID (United States); Miller, David Torbet [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2016-03-01

    This report contains the thermal (2200 m/s) and fast (E>1MeV) neutron fluence rate data for the ATF-1 holders located in core for ATR Cycle 157D which were measured by the Radiation Measurements Laboratory (RML) as requested by the Power Reactor Programs (ATR Experiments) Radiation Measurements Work Order. This report contains measurements of the fluence rates corresponding to the particular elevations relative to the 80-ft. core elevation. The data in this report consist of (1) a table of the ATR power history and distribution, (2) a hard copy listing of all thermal and fast neutron fluence rates, and (3) plots of both the thermal and fast neutron fluence rates. The fluence rates reported are for the average power levels given in the table of power history and distribution.

  13. ATR and transmission analysis of pigments by means of far infrared spectroscopy.

    Science.gov (United States)

    Kendix, Elsebeth L; Prati, Silvia; Joseph, Edith; Sciutto, Giorgia; Mazzeo, Rocco

    2009-06-01

    In the field of FTIR spectroscopy, the far infrared (FIR) spectral region has been so far less investigated than the mid-infrared (MIR), even though it presents great advantages in the characterization of those inorganic compounds, which are inactive in the MIR, such as some art pigments, corrosion products, etc. Furthermore, FIR spectroscopy is complementary to Raman spectroscopy if the fluorescence effects caused by the latter analytical technique are considered. In this paper, ATR in the FIR region is proposed as an alternative method to transmission for the analyses of pigments. This methodology was selected in order to reduce the sample amount needed for analysis, which is a must when examining cultural heritage materials. A selection of pigments have been analyzed in both ATR and transmission mode, and the resulting spectra were compared with each other. To better perform this comparison, an evaluation of the possible effect induced by the thermal treatment needed for the preparation of the polyethylene pellets on the transmission spectra of the samples has been carried out. Therefore, pigments have been analyzed in ATR mode before and after heating them at the same temperature employed for the polyethylene pellet preparation. The results showed that while the heating treatment causes only small changes in the intensity of some bands, the ATR spectra were characterized by differences in both intensity and band shifts towards lower frequencies if compared with those recorded in transmission mode. All pigments' transmission and ATR spectra are presented and discussed, and the ATR method was validated on a real case study. PMID:19266186

  14. Mutation analysis of the ATR gene in breast and ovarian cancer families

    International Nuclear Information System (INIS)

    Mutations in BRCA1, BRCA2, ATM, TP53, CHK2 and PTEN account for only 20–30% of the familial aggregation of breast cancer, which suggests the involvement of additional susceptibility genes. The ATR (ataxia-telangiectasia- and Rad3-related) kinase is essential for the maintenance of genomic integrity. It functions both in parallel and cooperatively with ATM, but whereas ATM is primarily activated by DNA double-strand breaks induced by ionizing radiation, ATR has been shown to respond to a much broader range of DNA damage. Upon activation, ATR phosphorylates several important tumor suppressors, including p53, BRCA1 and CHK1. Based on its central function in the DNA damage response, ATR is a plausible candidate gene for susceptibility to cancer. We screened the entire coding region of the ATR gene for mutations in affected index cases from 126 Finnish families with breast and/or ovarian cancer, 75 of which were classified as high-risk and 51 as moderate-risk families, by using conformation sensitive gel electrophoresis and direct sequencing. A large number of novel sequence variants were identified, four of which – Glu254Gly, Ser1142Gly, IVS24-48G>A and IVS26+15C>T – were absent from the tested control individuals (n = 300). However, the segregation of these mutations with the cancer phenotype could not be confirmed, partly because of the lack of suitable DNA samples. The present study does not support a major role for ATR mutations in hereditary susceptibility to breast and ovarian cancer

  15. Associations of ATR and CHEK1 single nucleotide polymorphisms with breast cancer.

    Directory of Open Access Journals (Sweden)

    Wei-Yu Lin

    Full Text Available DNA damage and replication checkpoints mediated by the ATR-CHEK1 pathway are key to the maintenance of genome stability, and both ATR and CHEK1 have been proposed as potential breast cancer susceptibility genes. Many novel variants recently identified by the large resequencing projects have not yet been thoroughly tested in genome-wide association studies for breast cancer susceptibility. We therefore used a tagging SNP (tagSNP approach based on recent SNP data available from the 1000 genomes projects, to investigate the roles of ATR and CHEK1 in breast cancer risk and survival. ATR and CHEK1 tagSNPs were genotyped in the Sheffield Breast Cancer Study (SBCS; 1011 cases and 1024 controls using Illumina GoldenGate assays. Untyped SNPs were imputed using IMPUTE2, and associations between genotype and breast cancer risk and survival were evaluated using logistic and Cox proportional hazard regression models respectively on a per allele basis. Significant associations were further examined in a meta-analysis of published data or confirmed in the Utah Breast Cancer Study (UBCS. The most significant associations for breast cancer risk in SBCS came from rs6805118 in ATR (p=7.6 x 10(-5 and rs2155388 in CHEK1 (p=3.1 x 10(-6, but neither remained significant after meta-analysis with other studies. However, meta-analysis of published data revealed a weak association between the ATR SNP rs1802904 (minor allele frequency is 12% and breast cancer risk, with a summary odds ratio (confidence interval of 0.90 (0.83-0.98 [p=0.0185] for the minor allele. Further replication of this SNP in larger studies is warranted since it is located in the target region of 2 microRNAs. No evidence of any survival effects of ATR or CHEK1 SNPs were identified. We conclude that common alleles of ATR and CHEK1 are not implicated in breast cancer risk or survival, but we cannot exclude effects of rare alleles and of common alleles with very small effect sizes.

  16. Potentiation of tumor responses to DNA damaging therapy by the selective ATR inhibitor VX-970

    OpenAIRE

    Hall, Amy B.; Newsome, Dave; Wang, Yuxin; Boucher, Diane M.; Eustace, Brenda; Gu, Yong; Hare, Brian; Mac A. Johnson; Milton, Sean; Murphy, Cheryl E.; Takemoto, Darin; Tolman, Crystal; Wood, Mark; Charlton, Peter; Charrier, Jean-Damien

    2014-01-01

    Platinum-based DNA-damaging chemotherapy is standard-of-care for most patients with lung cancer but outcomes remain poor. This has been attributed, in part, to the highly effective repair network known as the DNA-damage response (DDR). ATR kinase is a critical regulator of this pathway, and its inhibition has been shown to sensitize some cancer, but not normal, cells in vitro to DNA damaging agents. However, there are limited in vivo proof-of-concept data for ATR inhibition. To address this w...

  17. ATR-FTIR Spectroscopy in the Undergraduate Chemistry Laboratory: Part II--A Physical Chemistry Laboratory Experiment on Surface Adsorption

    Science.gov (United States)

    Schuttlefield, Jennifer D.; Larsen, Sarah C.; Grassian, Vicki H.

    2008-01-01

    Attenuated total reflectance-Fourier transform infrared (ATR-FTIR) spectroscopy is a useful technique for measuring the infrared spectra of solids and liquids as well as probing adsorption on particle surfaces. The use of FTIR-ATR spectroscopy in organic and inorganic chemistry laboratory courses as well as in undergraduate research was presented…

  18. GAMBARAN RISIKO TROMBOSIS VENA PROFUNDA (TVP PADA SALES PROMOTION GIRL (SPG BERDASARKAN KRITERIA WELLS DI KOTA DENPASAR

    Directory of Open Access Journals (Sweden)

    Shelly Silvia Bintang

    2015-01-01

    Full Text Available Pekerjaan sebagai sales promotion girl (SPG menuntut berdiri dalam posisi statis dalam waktu kerja yang cukup lama. Dalam sebuah jurnal kesehatan masyarakat tahun 2013 mendapatkan hasil semakin lama SPG bekerja maka semakin lama juga durasi mereka memakai sepatu hak tinggi semakin besar risiko untuk mengalami gangguan kesehatan yang disebabkan sepatu hak tinggi. Gangguan dari aliran darah atau trombosis vena profunda (TVP merupakan dampak yang ditimbulkan. Tujuan dari penelitian ini untuk mengetahui angka tinggi pemakaian sepatu hak tinggi, angka pemakaian stocking dan gambaran SPG di Kota Denpasar yang memiliki risiko rendah, menengah dan tinggi mengalami TVP. Penelitian ini menggunakan metode deskriptif potong lintang. Subyek penelitian ini adalah 62 pegawai SPG yang bekerja di swalayan di Kota Denpasar. Skor kriteria Wells didapatkan untuk mengetahui gambaran risiko probabilitas TVP. Hasil gambaran risiko TVP pada SPG di Kota Denpasar berdasarkan kriteria Wells didapatkan 30 orang pekerja (48,38% menunjukan risiko ringan, dan 30 orang pekerja lainnya (48,38% menunjukan risiko menengah menderita TVP, sedangkan 2 orang pekerja (3,24% menunjukan risiko tinggi. Sebagian besar pegawai SPG di kota Denpasar memiliki risiko rendah dan sedang probabilitas TVP.

  19. Keragaman suweg (Amorphophallus campanulatus di wilayah eks karesidenan Surakarta berdasarkan karakter morfologi, anatomi dan pola pita isozim

    Directory of Open Access Journals (Sweden)

    MONARITA PERMATASARI

    2014-05-01

    Full Text Available Permatasari, Pitoyo A, Suratman. 2014. Keragaman suweg (Amorphophallus campanulatus di wilayah eks karesidenan Surakarta berdasarkan karakter morfologi, anatomi dan pola pita isozim. Bioteknologi 11: 11-18. The aims of this research were to find out the diversity and relationship among elephant yam in Surakarta region based on variation of morphological, anatomical and isozyme banding patterns characters. Total 20 samples were taken using random purposive sampling technique in different altitude of 7 districts. Morphological, anatomical and isozyme banding pattern data were analyzed descriptively. The steady data of quantitative characteristic from morphological, anatomical and isozyme banding pattern of binary data was analyzed using an Index of Similarity (IS and computed by the program Numerical Taxonomy and Multivariate Analysis System (NTSYS version 2.10. The result showed that the elephant yam in Surakarta region were diverse based on morphological, anatomical and isozyme banding pattern, especially in ratio and color of petiolus; tuber ratio; index of stomatal; thick epidermis; thick mesophyll; term and ratio of palisade; term rafida; 4 peroxidase and 5 esterase isozyme banding pattern. Analysis of relationship of elephant yam based on morphological, anatomical and isozyme band pattern characters showed the similarity coefficient of 64,85% contained two major group. The first group consist of Boyolali 1, Boyolali 3, Boyolali 4, Wonogiri 4, Wonogiri 2, Karanganyar 1, Karanganyar 2, Karanganyar 3, Sragen 2, while the other samples were separated from this group.

  20. S-phase-dependent p50/NF-кB1 phosphorylation in response to ATR and replication stress acts to maintain genomic stability

    OpenAIRE

    Crawley, Clayton D.; Kang, Shijun; Bernal, Giovanna M; Wahlstrom, Joshua S.; Voce, David J; Cahill, Kirk E.; Garofalo, Andrea; Raleigh, David R.; Weichselbaum, Ralph R.; Yamini, Bakhtiar

    2015-01-01

    The apical damage kinase, ATR, is activated by replication stress (RS) both in response to DNA damage and during normal S-phase. Loss of function studies indicates that ATR acts to stabilize replication forks, block cell cycle progression and promote replication restart. Although checkpoint failure and replication fork collapse can result in cell death, no direct cytotoxic pathway downstream of ATR has previously been described. Here, we show that ATR directly reduces survival by inducing pho...

  1. Multivariate analysis of ATR-FTIR spectra for assessment of oil shale organic geochemical properties

    Science.gov (United States)

    Washburn, Kathryn E.; Birdwell, Justin E.

    2013-01-01

    In this study, attenuated total reflectance (ATR) Fourier transform infrared spectroscopy (FTIR) was coupled with partial least squares regression (PLSR) analysis to relate spectral data to parameters from total organic carbon (TOC) analysis and programmed pyrolysis to assess the feasibility of developing predictive models to estimate important organic geochemical parameters. The advantage of ATR-FTIR over traditional analytical methods is that source rocks can be analyzed in the laboratory or field in seconds, facilitating more rapid and thorough screening than would be possible using other tools. ATR-FTIR spectra, TOC concentrations and Rock–Eval parameters were measured for a set of oil shales from deposits around the world and several pyrolyzed oil shale samples. PLSR models were developed to predict the measured geochemical parameters from infrared spectra. Application of the resulting models to a set of test spectra excluded from the training set generated accurate predictions of TOC and most Rock–Eval parameters. The critical region of the infrared spectrum for assessing S1, S2, Hydrogen Index and TOC consisted of aliphatic organic moieties (2800–3000 cm−1) and the models generated a better correlation with measured values of TOC and S2 than did integrated aliphatic peak areas. The results suggest that combining ATR-FTIR with PLSR is a reliable approach for estimating useful geochemical parameters of oil shales that is faster and requires less sample preparation than current screening methods.

  2. FTIR-ATR Monitoring and SEC/RI/MALLS characterization of ATRP synthesized hyperbranched polyacrylates

    OpenAIRE

    Gonçalves, Miguel; Costa, Mário Rui; Dias, Rolando

    2009-01-01

    This work reports the synthesis at 1 L scale of hyperbranched polyacrylates based upon acrylate/diacrylate monomers such as n-butyl acrylate (nBA)/1,6-hexanediol diacrylate (HDDA) and using atom transfer radical polymerization (ATRP). A FTIR-ATR immersion probe was used to monitor the polymerization reaction. FCT

  3. PKA-mediated phosphorylation of ATR promotes recruitment of XPA to UV-induced DNA damage.

    Science.gov (United States)

    Jarrett, Stuart G; Wolf Horrell, Erin M; Christian, Perry A; Vanover, Jillian C; Boulanger, Mary C; Zou, Yue; D'Orazio, John A

    2014-06-19

    The melanocortin 1 receptor (MC1R), which signals through cAMP, is a melanocytic transmembrane receptor involved in pigmentation, adaptive tanning, and melanoma resistance. We report MC1R-mediated or pharmacologically-induced cAMP signaling promotes nucleotide excision repair (NER) in a cAMP-dependent protein kinase A (PKA)-dependent manner. PKA directly phosphorylates ataxia telangiectasia and Rad3-related protein (ATR) at Ser435, which actively recruits the key NER protein xeroderma pigmentosum complementation group A (XPA) to sites of nuclear UV photodamage, accelerating clearance of UV-induced photolesions and reducing mutagenesis. Loss of Ser435 within ATR prevents PKA-mediated ATR phosphorylation, disrupts ATR-XPA binding, delays recruitment of XPA to UV-damaged DNA, and elevates UV-induced mutagenesis. This study mechanistically links cAMP-PKA signaling to NER and illustrates potential benefits of cAMP pharmacological rescue to reduce UV mutagenesis in MC1R-defective, melanoma-susceptible individuals. PMID:24950377

  4. Dynamic generation of artificial HRSAR imagery for ATR development and cockpit simulation

    Science.gov (United States)

    Seidel, Heiko; Stahl, Christoph; Knappe, Peter; Hurst, Peter

    2004-09-01

    Following the tendency of increasingly using imaging sensors in military aircraft, future combat airplane pilots will need onboard artificial intelligence for aiding them in image interpretation and target designation. This document presents a system which is able to simulate high-resolution artificial SAR imagery and thereby facilitates automatic target recognition (ATR) algorithm development. The system provides a comprehensive interface that allows dynamically requesting imagery depending on the location and heading of a simulated carrier platform. Landscapes, structures and target signatures are generated based on digital terrain data and target models. An assessment of dissimilar database preparations for sensor simulation was done with respect to the different properties of SAR imaging compared to optical imaging. The document presents selected results for specific landscape elements. Post-processing algorithms for overcoming weaknesses of digital terrain databases and improving image realism are presented. Simulated sensor imagery is useful in a wide range of applications, two of which are training of ATR algorithms and sensor simulation in flight simulation environments. Using an existing ATR method as an example, the applicability and the influences of synthetic imagery on ATR training are shown and first approaches on how to validate the correctness of the imagery are explained. The integration of the system into a flight simulator in the context of interfacing and control topics serves as a concluding example.

  5. Solid Acid-Catalyzed Cellulose Hydrolysis Monitored by In Situ ATR-IR Spectroscopy

    NARCIS (Netherlands)

    Zakzeski, J.; Grisel, R.J.H.; Smit, A.T.; Weckhuysen, B.M.

    2012-01-01

    The solid acid-catalyzed hydrolysis of cellulose was studied under elevated temperatures and autogenous pressures using in situ ATR-IR spectroscopy. Standards of cellulose and pure reaction products, which include glucose, fructose, hydroxymethylfurfural (HMF), levulinic acid (LA), formic acid, and

  6. MATERNAL ATRAZINE (ATR) ALTERS HYPOTHALAMIC DOPAMINE (HYP-DA) AND SERUM PROLACTIN (SPRL) IN MALE PUPS

    Science.gov (United States)

    Maternal Atrazine (ATR) alters hypothalamic dopamine (HYP-DA) and serum prolactin (sPRL) in male pups. 1Christopher Langdale, 2Tammy Stoker and 2Ralph Cooper. 1 Dept. of Cell Biology, North Carolina State University College of Veterinary Medicine, Raleigh, NC. 2 Endocrinology ...

  7. Nanocrystalline diamond sensor targeted for selective CRP detection: an ATR-FTIR spectroscopy study.

    Science.gov (United States)

    Andersson, Per Ola; Viberg, Pernilla; Forsberg, Pontus; Nikolajeff, Fredrik; Österlund, Lars; Karlsson, Mikael

    2016-05-01

    Protein immobilization on functionalized fluorine-terminated nanocrystalline (NCD) films was studied by attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopy using an immobilization protocol developed to specifically bind C-reactive protein (CRP). Using an ATR-FTIR spectroscopy method employing a force-controlled anvil-type configuration, three critical steps of the ex situ CRP immobilization were analyzed. First, the NCD surface was passivated by deposition of a copolymer layer consisting of polyethylene oxide and polypropylene oxide. Second, a synthetic modified polypeptide binder with high affinity to CRP was covalently attached to the polymeric film. Third, CRP dissolved in aqueous buffer in concentrations of 10-20 μg/mL was added on the functionalized NCD surface. Both the amide I and II bands, due to the polypeptide binder and CRP, were clearly observed in ATR-FTIR spectra. CRP amide I bands were extracted from difference spectra and yielded bands that agreed well with the reported amide I band of free (non-bonded) CRP in solution. Thus, our results show that CRP retains its secondary structure when it is attached to the polypeptide binders. Compared to previous IR studies of CRP in solution, about 200 times lower concentration was applied in the present study. Graphical Abstract Direct non-destructive ATR-FTIR analysis of C-reactive protein (CRP) selectively bound to functionalized nanocrystalline diamond (NCD) sensor surface. PMID:27007740

  8. ATR Mediates a Checkpoint at the Nuclear Envelope in Response to Mechanical Stress

    Czech Academy of Sciences Publication Activity Database

    Kumar, A.; Mazzanti, M.; Mistrik, M.; Košař, Martin; Beznoussenko, G.V.; Mironov, A. A.; Garrè, M.; Parazolli, D.; Shivashankar, G. V.; Scita, G.; Bartek, Jiří; Foiani, M.

    2014-01-01

    Roč. 158, č. 3 (2014), s. 633-646. ISSN 0092-8674 Grant ostatní: Marie Curie Intra-European(IT) 274093 Institutional support: RVO:68378050 Keywords : ATR * Mechanical Stress * cell cycle Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 32.242, year: 2014

  9. Protein phosphatase 5 is necessary for ATR-mediated DNA repair

    Energy Technology Data Exchange (ETDEWEB)

    Kang, Yoonsung [Department of Pharmacology, DNA Repair Research Center, Chosun University School of Medicine, 375 Seosuk-Dong, Gwangju 501-759 (Korea, Republic of); Cheong, Hyang-Min [Department of Life Science, College of Natural Science, Chung-Ang University, 221 Heuksuk-Dong, Dongjak-Ku, Seoul 156-756 (Korea, Republic of); Lee, Jung-Hee [Department of Pharmacology, DNA Repair Research Center, Chosun University School of Medicine, 375 Seosuk-Dong, Gwangju 501-759 (Korea, Republic of); Song, Peter I. [Department of Dermatology, University of Arkansas for Medical Science, 4301 West Markham, Slot 576, Little Rock, AR 72205 (Korea, Republic of); Lee, Kwang-Ho [Department of Life Science, College of Natural Science, Chung-Ang University, 221 Heuksuk-Dong, Dongjak-Ku, Seoul 156-756 (Korea, Republic of); Kim, Sang-Yong [Division of Endocrinology, Department of Internal Medicine, Chosun University School of Medicine, 375 Seosuk-Dong, Gwangju 501-759 (Korea, Republic of); Jun, Jae Yeoul [Department of Physiology, Chosun University School of Medicine, 375 Seosuk-Dong, Gwangju 501-759 (Korea, Republic of); You, Ho Jin, E-mail: hjyou@chosun.ac.kr [Department of Pharmacology, DNA Repair Research Center, Chosun University School of Medicine, 375 Seosuk-Dong, Gwangju 501-759 (Korea, Republic of)

    2011-01-07

    Research highlights: {yields} Serine/threonine protein phosphatase 5 (PP5) has been shown to participate in ataxia telangiectasia-mutated (ATM)- and ATR (ATM- and Rad3-related)-mediated checkpoint pathways, which plays an important role in the DNA damage response and maintenance of genomic stability. {yields} However, it is not clear exactly how PP5 participates in this process. {yields} Our results indicate that PP5 is more closely related with ATR-mediated pathway than ATM-mediated pathway in DNA damage repair. -- Abstract: Several recent studies have shown that protein phosphatase 5 (PP5) participates in cell cycle arrest after DNA damage, but its roles in DNA repair have not yet been fully characterized. We investigated the roles of PP5 in the repair of ultraviolet (UV)- and neocarzinostatin (NCS)-induced DNA damage. The results of comet assays revealed different repair patterns in UV- and NCS-exposed U2OS-PS cells. PP5 is only essential for Rad3-related (ATR)-mediated DNA repair. Furthermore, the phosphorylation of 53BP1 and BRCA1, important mediators of DNA damage repair, and substrates of ATR and ATM decreased in U2OS-PS cells exposed to UV radiation. In contrast, the cell cycle arrest proteins p53, CHK1, and CHK2 were normally phosphorylated in U2OS and U2OS-PS cells exposed to UV radiation or treated with NCS. In view of these results, we suggest that PP5 plays a crucial role in ATR-mediated repair of UV-induced DNA damage.

  10. Protein phosphatase 5 is necessary for ATR-mediated DNA repair

    International Nuclear Information System (INIS)

    Research highlights: → Serine/threonine protein phosphatase 5 (PP5) has been shown to participate in ataxia telangiectasia-mutated (ATM)- and ATR (ATM- and Rad3-related)-mediated checkpoint pathways, which plays an important role in the DNA damage response and maintenance of genomic stability. → However, it is not clear exactly how PP5 participates in this process. → Our results indicate that PP5 is more closely related with ATR-mediated pathway than ATM-mediated pathway in DNA damage repair. -- Abstract: Several recent studies have shown that protein phosphatase 5 (PP5) participates in cell cycle arrest after DNA damage, but its roles in DNA repair have not yet been fully characterized. We investigated the roles of PP5 in the repair of ultraviolet (UV)- and neocarzinostatin (NCS)-induced DNA damage. The results of comet assays revealed different repair patterns in UV- and NCS-exposed U2OS-PS cells. PP5 is only essential for Rad3-related (ATR)-mediated DNA repair. Furthermore, the phosphorylation of 53BP1 and BRCA1, important mediators of DNA damage repair, and substrates of ATR and ATM decreased in U2OS-PS cells exposed to UV radiation. In contrast, the cell cycle arrest proteins p53, CHK1, and CHK2 were normally phosphorylated in U2OS and U2OS-PS cells exposed to UV radiation or treated with NCS. In view of these results, we suggest that PP5 plays a crucial role in ATR-mediated repair of UV-induced DNA damage.

  11. VE-821, an ATR inhibitor, causes radiosensitization in human tumor cells irradiated with high LET radiation

    International Nuclear Information System (INIS)

    High linear energy transfer (LET) radiation such as carbon ion particles is successfully used for treatment of solid tumors. The reason why high LET radiation accomplishes greater tumor-killing than X-rays is still not completely understood. One factor would be the clustered or complex-type DNA damages. We previously reported that complex DNA double-strand breaks produced by high LET radiation enhanced DNA end resection, and this could lead to higher kinase activity of ATR protein recruited to RPA-coated single-stranded DNA. Although the effect of ATR inhibition on cells exposed to low LET gamma-rays has recently been reported, little is known regarding the effect of ATR inhibitor on cells treated with high LET radiation. The purpose of this study is to investigate the effects of the ATR inhibitor VE-821 in human tumor and normal cells irradiated with high LET carbon ions. HeLa, U2OS, and 1BR-hTERT (normal) cells were pre-treated with 1 μM VE-821 for 1 hour and irradiated with either high LET carbon ions or X-rays. Cell survival, cell cycle distribution, cell growth, and micronuclei formation were evaluated. VE-821 caused abrogation of G2/M checkpoint and forced irradiated cells to divide into daughter cells. We also found that carbon ions caused a higher number of multiple micronuclei than X-rays, leading to decreased cell survival in tumor cells when treated with VE-821, while the survival of irradiated normal cells were not significantly affected by this inhibitor. ATR inhibitor would be an effective tumor radiosensitizer with carbon ion irradiation. The online version of this article (doi:10.1186/s13014-015-0464-y) contains supplementary material, which is available to authorized users

  12. Hubungan Kadar Ft4 Dengan Kejadian Tirotoksikosis berdasarkan Penilaian Indeks New Castle Padawanita Dewasa di Daerah Ekses Yodium

    Directory of Open Access Journals (Sweden)

    Harsa Rusda

    2013-05-01

    Full Text Available AbstrakTirotoksikosis merupakan manifestasi klinis yang terjadi akibat peningkatan kadar hormon tiroid dalam darah. Kelebihan yodium merupakan salah satu penyebab terjadinya tirotoksikosis. Ini ditandai dengan hasil pemeriksaan kadar Ekskresi Yodium Urin (EYU > 199 μg/L. Tujuan: Penelitian ini bertujuan untuk mengetahui hubungan kadar FT4 dengan kejadian tirotoksikosis berdasarkan penilaian indeks New Castle pada wanita dewasa di daerah ekses yodium. Metode: Penelitian dilakukan dengan menganalisis data yang dikumpulkan secara Cross Sectional Study terhadap 37 wanita dewasa menggunakan metoda total sampling di Nagari Koto Salak, Kecamatan Koto Salak Kabupaten Dharmasraya yang merupakan daerah ekses yodium (median EYU 323,5 μg/L. Pengumpulan data dilakukan dengan wawancara menggunakan penilaian Indeks New Castle dan pengambilan darah untuk dilakukan pemeriksaan kadar FT4 dalam serum. Hasil: Analisis univariat didapatkan jumlah penduduk wanita dewasa dengan kadar FT4 meningkat sebanyak 14 persen dan nilai rata-rata 1,71 ng/dl. Penilaian indeks New Castle dalam kategori doubtful 16 persen dan tidak ditemukan penduduk yang termasuk dalam kategori toxic. Berdasarkan hasil uji statistik Chi-square, didapatkan p value=1. Kesimpulan: Tidak terdapat hubungan yang bermakna antara kadar FT4 dalam serum dengan kejadian tirotoksikosis pada wanita dewasa di derah ekses yodium. Saran: Perlu dilakukan penyuluhan mengenai asupan yodium kepada masyarakat dan diharapkan penelitian ini dapat menjadi masukan kepada pemerintah dalam mengambil kebijakan terhadap pemberian kapsul yodium serta melakukan kontrol kadar EYU secara teratur dan berkala.Kata kunci: FT4, tirotoksikosis, indeks New Castle, wanita, ekses yodium, tiroidAbstractThyrotoxicosis is a clinical manifestation that occurs due to elevated levels of thyroid hormones in the blood. Iodine excess is one of the causes of thyrotoxicosis. This is indicated by the results of urine iodine excretion levels (EYU

  13. Advanced Test Reactor National Scientific User Facility (ATR NSUF) Monthly Report November 2014

    Energy Technology Data Exchange (ETDEWEB)

    Soelberg, Renae [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2014-11-01

    Advanced Test Reactor National Scientific User Facility (ATR NSUF) Monthly Report November 2014 Highlights Rory Kennedy and Sarah Robertson attended the American Nuclear Society Winter Meeting and Nuclear Technology Expo in Anaheim, California, Nov. 10-13. ATR NSUF exhibited at the technology expo where hundreds of meeting participants had an opportunity to learn more about ATR NSUF. Dr. Kennedy briefed the Nuclear Engineering Department Heads Organization (NEDHO) on the workings of the ATR NSUF. • Rory Kennedy, James Cole and Dan Ogden participated in a reactor instrumentation discussion with Jean-Francois Villard and Christopher Destouches of CEA and several members of the INL staff. • ATR NSUF received approval from the NE-20 office to start planning the annual Users Meeting. The meeting will be held at INL, June 22-25. • Mike Worley, director of the Office of Innovative Nuclear Research (NE-42), visited INL Nov. 4-5. Milestones Completed • Recommendations for the Summer Rapid Turnaround Experiment awards were submitted to DOE-HQ Nov. 12 (Level 2 milestone due Nov. 30). Major Accomplishments/Activities • The University of California, Santa Barbara 2 experiment was unloaded from the GE-2000 at HFEF. The experiment specimen packs will be removed and shipped to ORNL for PIE. • The Terrani experiment, one of three FY 2014 new awards, was completed utilizing the Advanced Photon Source MRCAT beamline. The experiment investigated the chemical state of Ag and Pd in SiC shell of irradiated TRISO particles via X-ray Absorption Fine Structure (XAFS) spectroscopy. Upcoming Meetings/Events • The ATR NSUF program review meeting will be held Dec. 9-10 at L’Enfant Plaza. In addition to NSUF staff and users, NE-4, NE-5 and NE-7 representatives will attend the meeting. Awarded Research Projects Boise State University Rapid Turnaround Experiments (14-485 and 14-486) Nanoindentation and TEM work on the T91, HT9, HCM12A and 9Cr ODS specimens has been completed at

  14. Coupling of phonon-polariton modes at dielectric-dielectric interfaces by the ATR technique

    Science.gov (United States)

    Cocoletzi, G. H.; Olvera Hernández, J.; Martínez Montes, G.

    1989-08-01

    We report the calculated ATR dispersion relation of the interface phonon-polariton modes in the prism-dielectric-dielectric configuration. Comparison of electromagnetic dispersion relations (EMDR) with the ATR dispersion relations are presented for three different interfaces: I) GaAs/GaP, II) CdF2/CaF2 and III) CaF2/GaP in two propagation windows, using the Otto and Kretschmann geometries for p-polarized light. We have studied the three cases using angle and frequency scans for each window and geometry. The results indicate that it is possible to excite and detect phonon-polariton modes at the dielectric-dielectric interface.

  15. Phylogeny of cultivated and wild wheat species using ATR-FTIR spectroscopy

    Science.gov (United States)

    Demir, Pinar; Onde, Sertac; Severcan, Feride

    2015-01-01

    Within the last decade, an increasing amount of genetic data has been used to clarify the problems inherent in wheat taxonomy. The techniques for obtaining and analyzing these data are not only cumbersome, but also expensive and technically demanding. In the present study, we introduce infrared spectroscopy as a method for a sensitive, rapid and low cost phylogenetic analysis tool for wheat seed samples. For this purpose, 12 Triticum and Aegilops species were studied by Attenuated Total Reflection-Fourier Transform Infrared (ATR-FTIR) spectroscopy. Hierarchical cluster analysis and principal component analysis clearly revealed that the lignin band (1525-1505 cm-1) discriminated the species at the genus level. However, the species were clustered according to their genome commonalities when the whole spectra were used (4000-650 cm-1). The successful differentiation of Triticum and its closely related genus Aegilops clearly demonstrated the power of ATR-FTIR spectroscopy as a suitable tool for phylogenetic research.

  16. ATR-A1 irradiation experiment on vanadium alloys and low activation steels

    Energy Technology Data Exchange (ETDEWEB)

    Tasi, H.; Strain, R.V.; Gomes, I.; Hins, A.G.; Smith, D.L.

    1996-04-01

    To study the mechanical properties of vanadium alloys under neutron irradiation at low temperatures, an experiment was designed and constructed for irradiation in the Advanced Test Reactor (ATR). The experiment contained Charpy, tensile, compact tension, TEM, and creep specimens of vanadium alloys. It also contained limited low-activation ferritic steel specimens as part of the collaborative agreement with Monbusho of Japan. The design irradiation temperatures for the vanadium alloy specimens in the experiment are {approx}200 and 300{degrees}C, achieved with passive gap-gap sizing and fill gas blending. To mitigate vanadium-to-chromium transmutation from the thermal neutron flux, the test specimens are contained inside gadolinium flux filters. All specimens are lithium-bonded. The irradiation started in Cycle 108A (December 3, 1995) and is expected to have a duration of three ATR cycles and a peak influence of 4.4 dpa.

  17. An Approach for Routine Analytical Detection of Beeswax Adulteration Using FTIR-ATR Spectroscopy

    OpenAIRE

    Svečnjak Lidija; Baranović Goran; Vinceković Marko; Prđun Saša; Bubalo Dragan; Tlak Gajger Ivana

    2015-01-01

    Although beeswax adulteration represents one of the main beeswax quality issues, there are still no internationally standardised analytical methods for routine quality control. The objective of this study was to establish an analytical procedure suitable for routine detection of beeswax adulteration using FTIR-ATR spectroscopy. For the purpose of this study, reference IR spectra of virgin beeswax, paraffin, and their mixtures containing different proportions of paraffin (5 - 95%), were obtain...

  18. ATR-FTIR spectroscopy and chemometrics: An interesting tool to discriminate and characterize counterfeit medicines.

    Science.gov (United States)

    Custers, D; Cauwenbergh, T; Bothy, J L; Courselle, P; De Beer, J O; Apers, S; Deconinck, E

    2015-08-10

    Counterfeit medicines pose a huge threat to public health worldwide. High amounts of counterfeit pharmaceuticals enter the European market and therefore detection of these products is essential. Attenuated Total Reflection Fourier-Transform infrared spectroscopy (ATR-FTIR) might be useful for the screening of counterfeit medicines since it is easy to use and little sample preparation is required. Furthermore, this approach might be helpful to customs to obtain a first evaluation of suspected samples. This study proposes a combination of ATR-FTIR and chemometrics to discriminate and classify counterfeit medicines. A sample set, containing 209 samples in total, was analyzed using ATR-FTIR and the obtained spectra were used as fingerprints in the chemometric data-analysis which included Principal Component Analysis (PCA), k-Nearest Neighbours (k-NN), Classification and Regression Trees (CART) and Soft Independent Modelling of Class Analogy (SIMCA). First it was verified whether the mentioned techniques are capable to distinguish samples containing different active pharmaceutical ingredients (APIs). PCA showed a clear tendency of discrimination based on the API present; k-NN, CART and SIMCA were capable to create suitable prediction models based on the presence of different APIs. However k-NN performs the least while SIMCA performs the best. Secondly, it was tested whether these three models could be expanded to discriminate between genuine and counterfeit samples as well. k-NN was not able to make the desired discrimination and therefore it was not useful. CART performed better but also this model was less suited. SIMCA, on the other hand, resulted in a model with a 100% correct discrimination between genuine and counterfeit drugs. This study shows that chemometric analysis of ATR-FTIR fingerprints is a valuable tool to discriminate genuine from counterfeit samples and to classify counterfeit medicines. PMID:25476739

  19. High resolution ATR FTIR spectroscopy of hydrogenated diamond nanoparticles using diamond-coated prism

    Czech Academy of Sciences Publication Activity Database

    Remeš, Zdeněk; Kozak, Halyna; Rezek, Bohuslav; Babchenko, Oleg; Kromka, Alexander; Girard, H.A.; Petit, T.; Arnault, J.-C.; Bergonzo, P.

    Tokyo : Prime International Co, 2011. s. 128. [International Conference on New Diamond and Nano carbons 2011 (NDNC 2011). 16.05.2011.-20.05.2011, Kunibiki Messe, Matsue] R&D Projects: GA MŠk LC510 Grant ostatní: AVČR(CZ) M100100902 Institutional research plan: CEZ:AV0Z10100521 Keywords : nanodiamond * ATR FTIR * hydrogenation Subject RIV: BM - Solid Matter Physics ; Magnetism

  20. FTIR-ATR spectroscopy – a new approach in root discrimination of crop and weed species

    OpenAIRE

    Meinen, Catharina; Rauber, Rolf

    2012-01-01

    Crop and weed species often compete for the same resources. To analyse below-ground competitive processes, crop and weed roots have to be distinguished from one another. Up to now, a reliable and easy method for plant root discrimination does not exist. In a recent study, Fourier transform infrared (FTIR) spectroscopy with an attenuated total reflection (ATR) device was successfully applied in root discrimination of distantly related plant species (pea/oat). In this experiment, we wanted to t...

  1. The Conference Proceedings of the 2003 Air Transport Research Society (ATRS) World Conference, Volume 3

    Science.gov (United States)

    Bowen, Brent (Editor); Gudmundsson, Sveinn (Editor); Oum, Tae (Editor)

    2003-01-01

    Volume 3 of the 2003 Air Transport Reserch Society (ATRS) World Conference includes papers on topics relevant to airline operations worldwide. Specific topics include: European Union and civil aviation regimens;simulating decision making in airline operations, passenger points of view on convenient airports; route monopolies and nonlinear pricing; cooperation among airports in Europe; fleet modernizaiton in Brazil;the effects of deregulation on the growth of air transportation in Europe and the United States.

  2. Testing of the atr system of Leica TCRA 1103 plus total station

    OpenAIRE

    Šketa, Matic

    2014-01-01

    The aim of this paper is to test the automatic target recognition system of Leica TCRA1103 plus total station. A total station enables the automatic target recognition. The introductory part of my research is based on the development and automation of electronic total stations. Furthermore, the research is dedicated to the automatic target identifying system of Leica ATR. The aim of the practical part of this research is to test the accuracy of Leica TCRA1103 plus total station at horizont...

  3. Enhanced ATR algorithm for high resolution multi-band sonar imagery

    Science.gov (United States)

    Aridgides, Tom; Fernández, Manuel

    2008-04-01

    An improved automatic target recognition (ATR) processing string has been developed. The overall processing string consists of pre-processing, subimage adaptive clutter filtering (SACF), normalization, detection, data regularization, feature extraction, optimal subset feature selection, feature orthogonalization and classification processing blocks. A new improvement was made to the processing string, data regularization, which entails computing the input data mean, clipping the data to a multiple of its mean and scaling it, prior to feature extraction. The classified objects of 3 distinct strings are fused using the classification confidence values and their expansions as features, and using "summing" or log-likelihood-ratio-test (LLRT) based fusion rules. The utility of the overall processing strings and their fusion was demonstrated with new high-resolution three-frequency band sonar imagery. The ATR processing strings were individually tuned to the corresponding three-frequency band data, making use of the new processing improvement, data regularization, which resulted in a 3:1 reduction in false alarms. Two significant fusion algorithm improvements were made. First, a nonlinear 2nd order (Volterra) feature LLRT fusion algorithm was developed. Second, a repeated application of a subset Volterra feature selection / feature orthogonalization / LLRT fusion block was utilized. It was shown that cascaded Volterra feature LLRT fusion of the ATR processing strings outperforms baseline summing and single-stage Volterra feature LLRT algorithms, yielding significant improvements over the best single ATR processing string results, and providing the capability to correctly call the majority of targets while maintaining a very low false alarm rate.

  4. Fast quantitative determination of microbial rhamnolipids from cultivation broths by ATR-FTIR Spectroscopy

    Directory of Open Access Journals (Sweden)

    Hausmann Rudolf

    2008-10-01

    Full Text Available Abstract Background Vibrational spectroscopic techniques are becoming increasingly important and popular because they have the potential to provide rapid and convenient solutions to routine analytical problems. Using these techniques, a variety of substances can be characterized, identified and also quantified rapidly. Results The rapid ATR-FTIR (Attenuated Total Reflectance Fourier Transform Infrared Spectroscopy in time technique has been applied, which is suitable to quantify the concentrations of microbial rhamnolipids in a typical cultivation process. While the usually applied HPLC analysis requires an extensive and time consuming multi step extraction protocol for sample preparation, the ATR-FTIR-method allows the quantification of the rhamnolipids within 20 minutes. Accuracies between 0.5 g/l – 2.1 g/l for the different analytes were determined by cross validation of the calibration set. Even better accuracies between 0.28 g/l – 0.59 g/l were found for independent test samples of an arbitrarily selected cultivation. Conclusion ATR-FTIR was found to be suitable for the rapid analysis of rhamnolipids in a biotechnological process with good reproducibility in sample determination and sufficient accuracy. An improvement in accuracy through continuous expansion and validation of the reference spectra set seems very likely.

  5. ATR-IR Investigation of Solvent Interactions with Surface-Bound Polymers

    Science.gov (United States)

    2016-01-01

    Solvent interactions with bulk and surface-bound polymer brushes are crucial for functionalities such as controlled friction and thermoresponsive adhesion. To study such interactions, the temperature-induced solvent-quality changes and the effect of surface tethering on the mechanical and tribological properties of poly(dodecyl methacrylate) (P12MA) brushes have been investigated by means of attenuated total reflection infrared spectroscopy (ATR-IR), as well as atomic force microscopy (AFM) and lateral force microscopy (LFM). These results have been compared with temperature-dependent UV–visible spectrophotometry (UV–vis) data for the corresponding bulk polymer solutions. The ATR-IR results clearly show that increasing temperature enhances ethanol uptake in P12MA, which results in film swelling. This is accompanied by a marked increase in both adhesion and friction. We have also shown that a combination of solvents, such as toluene and ethanol, can lead to a temperature-dependent solvent partitioning within the polymer brush. To our knowledge this is the first time preferential solvent uptake in a grafted-from brush has been monitored via in situ ATR-IR. Moreover, we have observed remarkably different behavior for polymer chains in solution compared to the behavior of similar chains bound to a surface. The presented findings on the temperature-dependent solvent interactions of surface-grafted P12MA reveal previously unknown solvation phenomena and open up a range of possible applications in the area of stimuli-responsive materials. PMID:27397856

  6. Diamond-coated ATR prism for infrared absorption spectroscopy of surface-modified diamond nanoparticles

    International Nuclear Information System (INIS)

    Linear antenna microwave chemical vapor deposition process was used to homogeneously coat a 7 cm long silicon prism by 85 nm thin nanocrystalline diamond (NCD) layer. To show the advantages of the NCD-coated prism for attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR) of nanoparticles, we apply diamond nanoparticles (DNPs) of 5 nm nominal size with various surface modifications by a drop-casting of their methanol dispersions. ATR-FTIR spectra of as-received, air-annealed, plasma-oxidized, and plasma-hydrogenated DNPs were measured in the 4000–1500 cm−1 spectral range. The spectra show high spectral resolution, high sensitivity to specific DNP surface moieties, and repeatability. The NCD coating provides mechanical protection against scratching and chemical stability of the surface. Moreover, unlike on bare Si surface, NCD hydrophilic properties enable optically homogeneous coverage by DNPs with some aggregation on submicron scale as evidenced by scanning electron microscopy and atomic force microscopy. Compared to transmission FTIR regime with KBr pellets, direct and uniform deposition of DNPs on NCD-ATR prism significantly simplifies and speeds up the analysis (from days to minutes). We discuss prospects for in situ monitoring of surface modifications and molecular grafting.

  7. FTIR-ATR spectroscopy applied to quality control of grape-derived spirits.

    Science.gov (United States)

    Anjos, Ofélia; Santos, António J A; Estevinho, Letícia M; Caldeira, Ilda

    2016-08-15

    The Fourier transform infrared (FTIR) spectroscopic method with attenuated total reflectance (ATR) was used for predicting the alcoholic strength, the methanol, acetaldehyde and fusel alcohols content of grape-derived spirits. FTIR-ATR spectrum in the mid-IR region (4000-400cm(-1)) was used for the quantitative estimation by applying partial least square (PLS) regression models and the results were correlated with those obtained from reference methods. In the developed method, a cross-validation with 50% of the samples was used for PLS analysis along with a validation test set with 50% of the remaining samples. Good correlation models with a great accuracy were obtained for methanol (r(2)=99.4; RPD=12.8), alcoholic strength (r(2)=97.2; RPD=6.0), acetaldehyde (r(2)=98.2; RPD=7.5) and fusel alcohols (r(2) from 97.4 to 94.1; RPD from 6.2 to 4.1). These results corroborate the hypothesis that FTIR-ATR is a useful technique for the quality control of grape-derived spirits, whose practical application may improve the efficiency and quickness of the current laboratory analysis. PMID:27006210

  8. Cyclohexene Photo-oxidation over Vanadia Catalyst Analyzed by Time Resolved ATR-FT-IR Spectroscopy

    Energy Technology Data Exchange (ETDEWEB)

    Frei, Heinz; Mul, Guido; Wasylenko, Walter; Hamdy, M. Sameh; Frei, Heinz

    2008-06-04

    Vanadia was incorporated in the 3-dimensional mesoporous material TUD-1 with a loading of 2percent w/w vanadia. The performance in the selective photo-oxidation of liquid cyclohexene was investigated using ATR-FT-IR spectroscopy. Under continuous illumination at 458 nm a significant amount of product, i.e. cyclohexenone, was identified. This demonstrates for the first time that hydroxylated vanadia centers in mesoporous materials can be activated by visible light to induce oxidation reactions. Using the rapid scan method, a strong perturbation of the vanadyl environment could be observed in the selective oxidation process induced by a 458 nm laser pulse of 480 ms duration. This is proposed to be caused by interaction of the catalytic centre with a cyclohexenyl hydroperoxide intermediate. The restoration of the vanadyl environment could be kinetically correlated to the rate of formation of cyclohexenone, and is explained by molecular rearrangement and dissociation of the peroxide to ketone and water. The ketone diffuses away from the active center and ATR infrared probing zone, resulting in a decreasing ketone signal on the tens of seconds time scale after initiation of the photoreaction. This study demonstrates the high potential of time resolved ATR FT-IR spectroscopy for mechanistic studies of liquid phase reactions by monitoring not only intermediates and products, but by correlating the temporal behavior of these species to molecular changes of the vanadyl catalytic site.

  9. Perbedaan Perlukaan Genitalia Perempuan Berdasarkan Posisi Persetubuhan Diluar Perkawinan di RSUP Dr. M. Djamil Padang Tahun 2010-2012

    Directory of Open Access Journals (Sweden)

    Ami Tri Nursasmi

    2014-05-01

    Full Text Available AbstrakPersetubuhan diluar perkawinan menjadi suatu masalah di pengadilan karena banyaknya perbedaan pendapat mengenai perlukaan selaput dara. Penelitian ini dilakukan untuk membuktikan perbedaan perlukaan selaput dara tersebut yang dilakukan di RSUP Dr. M. Djamil Padang, mencakup karakteristik korban, perlukaan selaput dara, perlukaan dibagian tubuh lain, dan hubungan perlukaan berdasarkan posisi persetubuhan. Penelitian ini bersifat analitik. Sampel sebanyak 81 responden yang telah mengalami persetubuhan diluar perkawinan. Data diambil dari Bagian Forensik RSUP Dr. M. Djamil Padang periode bulan Juli 2010 sampai dengan Juli 2012. Data diolah dengan menggunakan program komputer dan dianalisis melalui uji chi square. Dari 81 subjek penelitian ditemukan hasil tertinggi berupa usia korban adalah 12-18 tahun (62%, pekerjaan sebagai pelajar (56%, alamat berada di Kecamatan Koto Tangah (20%, hubungan korban dengan pelaku sebagai pacar (48%, perlukaan selaput dara pada arah jarum jam selain 5 dan 7 (47%, tidak tampaknya tanda-tanda kekerasan dibagian tubuh lain (81%. Dari uji chi square didapatkan nilai p = 0,585 dengan demikian Ha penelitian ditolak (p>0,05. Penelitian ini dapat disimpulkan bahwa tidak terdapatnya hubungan yang signifikan antara perlukaan selaput dara dengan posisi persetubuhan diluar perkawinan.Kata kunci: Persetubuhan, selaput dara, perlukaanAbstractNon marital sexual activity has been being a big issues on the court because there are contradictions argument about wounded hymen. This research is conducted to prove the difference of that wound occurs in public hospital of dr.M.Djamil Padang, including the victim’s character, hymen’s injury, another injury in other parts body, and the connection of each injuries based on intercourse position. This research having an analitical nature. 81 respondents of sample who done non marital sexual activity. The data taken from Forensics division of RSUP dr.M.Djamil Padang for period of July

  10. Larangan Gratifikasi Dalam Rangka Good Corporate Governance Di BUMN Berdasarkan Undang-Undang Nomor 31 Tahun 1999 Jo Undang-Undang Nomor 20 Tahun 2001 Tentang Pemberantasan Tindak Pidana Korupsi (Studi pada PT.Perkebunan Nusantara III)

    OpenAIRE

    Tarigan, Jimmy Ardhianta

    2010-01-01

    Badan Usaha Milik Negara (BUMN) merupakan salah satu tiang perekonomian nasional. Dalam sistem perekonomian nasional, BUMN berperan sebagai pelaksana pelayanan publik, membantu pengembangan usaha kecil dan koperasi, penyeimbang kekuatan swasta besar atau mengganti kekuatan swasta lemah. Pada Badan Usaha Milik Negara dimana saham perusahaan sebagian besar dipegang oleh negara melalui kementrian BUMN, sehingga sangat ditekankan untuk menerapkan sistem perusahaan yang berdasarkan kepada prinsip-...

  11. Kualitas Air Minum Yang Diproduksi Depot Air Minum Isi Ulang Di Kecamatan Bungus Padang Berdasarkan Persyaratan Mikrobiologi

    Directory of Open Access Journals (Sweden)

    Rido Wandrivel

    2012-11-01

    Full Text Available Abstrak Latar belakang: Pendahuluan: Setiap depot air minum wajib melakukan pemeriksaan mutu produk sesuai dengan peraturan yang berlaku, namun tidak satupun dari sembilan depot air minum di Kecamatan Bungus melakukan hal tersebut. Diare adalah salah satu penyakit yang disebabkan oleh air minum yang tidak berkualitas. Morbiditas rate diare di Kecamatan Bungus tertinggi ke-2 di Kota Padang. Penelitian ini bertujuan untuk mengetahui kualitas air minum yang dihasilkan depot air minum di Kecamatan Bungus berdasarkan persyaratan mikrobiologi. Metode Penelitian: Populasi pada penelitian ini adalah air minum yang berasal dari depot air minum isi ulang di Kecamatan Bungus Padang dan sampel pada penelitian ini adalah seluruh populasi yang ada, yaitu sembilan sampel. Penelitian dilaksanakan dalam 2 tahap yaitu pengambilan sampel air dengan galon air sekaligus observasi faktor yang mempengaruhi kualitas air dan pemeriksaan mikrobiologis dengan Most Probable Number Test (MPN terhadap sampel yang terdiri dari tiga tes, yaitu presumptive test, confirmative test, dan complete test. Hasil Penelitian: Lima dari sembilan sampel mengandung bakteri Coliform dan tiga dari lima sampel tersebut juga mengandung E. coli. Kesimpulan: Hal ini menunjukkan bahwa 55,6% depot air minum di Kecamatan Bungus menghasilkan air minum yang kualitasnya tidak memenuhi persyaratan mikrobiologi yang telah ditetapkan pemerintah. Beberapa faktor yang dapat mempengaruhi adalah air baku, kondisi depot, kebersihan operator, dan penanganan terhadap wadah pembeli. Kata kunci: Depot air minum isi ulang, pemeriksaan mikrobiologis Abstract Background: Every depot is obliged to do inspection of product quality prescribed by the regulations, but not one even also from nine drinking water depot in District of Bungus do the mentioned. Diarrhea is one of the disease that cause by bad quality water product. Diarrhea morbidity rate in the Bungus District is second highest in Padang City. This Research

  12. ANALISIS KELAYAKAN ISI BUKU TEKS MATA PELAJARAN EKONOMI SMA KELAS X BERDASARKAN KURIKULUM TINGKAT SATAUAN PENDIDIKAN ( KTSP DI KABUPATEN SEMARANG

    Directory of Open Access Journals (Sweden)

    Koeri Ulinuha

    2016-02-01

    Full Text Available Tujuan penelitian ini adalah untuk mengetahui apakah buku teks ekonomi SMA kelas X yang digunakan di Kabupaten Semarang sudah memenuhi standar kelayakan isi buku teks ekonomi menurut BSNP. Dan manfaat penelitian ini dapat memilih dan mempertimbankan dalam memilih buku teks pelajaran untuk refrensi belajar baik pihak siswa, guru dan pihak sekolahPenelitian ini dilakuakan terhadap isi buku teks pelajaran yang dianalisis secara kualitatif. Sehingga penelitian ini disebut penelitian deskriptif kualitatif. Teknik penelitian yang di gunakan adalah adalah teknik triangulasi. Analisis buku teks ekonomi untuk SMA kelas X melibatkan 5 orang penilai, yaitu 5 guru ekonomi. Dari 5 SMAN yang mengunakan buku teks pelajaran ekonomi dengan pengarang Alam S. dan penerbit Esis. Teknik pengumpulan data dengan lembar penilaian buku teks ekonomi dari BSNP dan menggunakan teknik wawancara terhadap dua guru ekonomi untuk memperkuat hasil dari penilaian dari buku teks ekonomi kelas X.Data yang diperoleh dalam penelitian ini berupa hasil penilaian yang berupa skor penilian dan hasil wawancara. Berdasarkan hasil analisis dapat disimpulkan bahwa buku ekonomi SMA Kelas X karangan Alam S. yang digunakan di Kabupaten Semarang sudah memenuhi standar kelayakan isi menurut BSNP. Buku teks ekonomi untuk SMA Kelas X karangan Alam S. dapat digunakan sebagai sumber belajar dalam pembelajaran ekonomi di SMA kelas X. Selain itu, perlu diadakan penelitian lebih lanjut untuk menganalisis buku teks ekonomi lain yang digunakan di Kabupaten Semarang.. The purpose of this research was to know whether textbooks high school economics class X used in Semarang Regancy already meet the standards of eligibility of the contents of the textbook economics according to BSNP. Analysis of economic text books for high school classes X involves 5 persons appraisers, i.e. 5 economics teacher. From 5 SMAN using textbook economics lessons with author and Publisher Alam S. Esis.. Data collection techniques

  13. Root discrimination of closely related crop and weed species using FT MIR-ATR spectroscopy

    Directory of Open Access Journals (Sweden)

    Catharina eMeinen

    2015-09-01

    Full Text Available Root discrimination of species is a pre-condition for studying belowground competition processes between crop and weed species. In this experiment, we tested Fourier transform mid-infrared (FT MIR-attenuated total reflection (ATR spectroscopy to discriminate roots of closely related crop and weed species grown in the greenhouse: maize/barnyard grass, barley/wild oat, wheat/blackgrass (Poaceae, and sugar beet/common lambsquarters (Chenopodiaceae. Fresh (moist and dried root segments as well as ground roots were analyzed by FT MIR-ATR spectroscopy. Root absorption spectra showed species specific peak distribution and peak height. A clear separation according to species was not possible with fresh root segments. Dried root segments (including root basis, middle section and root tip of maize/barnyard grass and sugar beet/common lambsquarters formed completely separated species clusters. Wheat and blackgrass separated in species specific clusters when root tips were removed from cluster analysis. A clear separation of dried root segments according to species was not possible in the case of barley and wild oat. Cluster analyses of ground roots revealed a 100 % separation of all tested crop and weed species combinations. Spectra grouped in Poaceae and Chenopodiaceae clusters. Within the Poaceae cluster, C3 and C4 species differed significantly in heterogeneity. Thus, root spectra reflected the degree of kinship. To quantify species proportion in root mixtures, a two- and a three-species model for species quantification in root mixtures of maize, barnyard grass, and wild oat was calculated. The models showed low standard errors of prediction (RMSEP and high residual predictive deviation (RPD values in an external test set validation. Hence, FT MIR-ATR spectroscopy seems to be a promising tool for root research even between closely related plant species.

  14. Cleaning-in-place of immunoaffinity resins monitored by in situ ATR-FTIR spectroscopy.

    Science.gov (United States)

    Boulet-Audet, Maxime; Byrne, Bernadette; Kazarian, Sergei G

    2015-09-01

    In the next 10 years, the pharmaceutical industry anticipates that revenue from biotherapeutics will overtake those generated from small drug molecules. Despite effectively treating a range of chronic and life-threatening diseases, the high cost of biotherapeutics limits their use. For biotherapeutic monoclonal antibodies (mAbs), an important production cost is the affinity resin used for protein capture. Cleaning-in-place (CIP) protocols aim to optimise the lifespan of the resin by slowing binding capacity decay. Binding assays can determine resin capacity from the mobile phase, but do not reveal the underlying causes of Protein A ligand degradation. The focus needs to be on the stationary phase to examine the effect of CIP on the resin. To directly determine both the local Protein A ligand concentration and conformation on two Protein A resins, we developed a method based on attenuated total reflection (ATR) Fourier transform infrared (FTIR) spectroscopy. ATR-FTIR spectroscopic imaging revealed that applying a carefully controlled load to agarose beads produces an even and reproducible contact with the internal reflection element. This allowed detection and quantification of the binding capacity of the stationary phase. ATR-FTIR spectroscopy also showed that Protein A proteolysis does not seem to occur under typical CIP conditions (below 1 M NaOH). However, our data revealed that concentrations of NaOH above 0.1 M cause significant changes in Protein A conformation. The addition of >0.4 M trehalose during CIP significantly reduced NaOH-induced ligand unfolding observed for one of the two Protein A resins tested. Such insights could help to optimise CIP protocols in order to extend resin lifetime and reduce mAb production costs. PMID:26159572

  15. Radiosensitization of Human Leukemic HL-60 Cells by ATR Kinase Inhibitor (VE-821: Phosphoproteomic Analysis

    Directory of Open Access Journals (Sweden)

    Barbora Šalovská

    2014-07-01

    Full Text Available DNA damaging agents such as ionizing radiation or chemotherapy are frequently used in oncology. DNA damage response (DDR—triggered by radiation-induced double strand breaks—is orchestrated mainly by three Phosphatidylinositol 3-kinase-related kinases (PIKKs: Ataxia teleangiectasia mutated (ATM, DNA-dependent protein kinase (DNA-PK and ATM and Rad3-related kinase (ATR. Their activation promotes cell-cycle arrest and facilitates DNA damage repair, resulting in radioresistance. Recently developed specific ATR inhibitor, VE-821 (3-amino-6-(4-(methylsulfonylphenyl-N-phenylpyrazine-2-carboxamide, has been reported to have a significant radio- and chemo-sensitizing effect delimited to cancer cells (largely p53-deficient without affecting normal cells. In this study, we employed SILAC-based quantitative phosphoproteomics to describe the mechanism of the radiosensitizing effect of VE-821 in human promyelocytic leukemic cells HL-60 (p53-negative. Hydrophilic interaction liquid chromatography (HILIC-prefractionation with TiO2-enrichment and nano-liquid chromatography—tandem mass spectrometry (LC-MS/MS analysis revealed 9834 phosphorylation sites. Proteins with differentially up-/down-regulated phosphorylation were mostly localized in the nucleus and were involved in cellular processes such as DDR, all phases of the cell cycle, and cell division. Moreover, sequence motif analysis revealed significant changes in the activities of kinases involved in these processes. Taken together, our data indicates that ATR kinase has multiple roles in response to DNA damage throughout the cell cycle and that its inhibitor VE-821 is a potent radiosensitizing agent for p53-negative HL-60 cells.

  16. Hydraulic Shuttle Irradiation System (HSIS) Recently Installed in the Advanced Test Reactor (ATR)

    International Nuclear Information System (INIS)

    Most test reactors are equipped with shuttle facilities (sometimes called rabbit tubes) whereby small capsules can be inserted into the reactor and retrieved during power operations. With the installation of Hydraulic Shuttle Irradiation System (HSIS) this capability has been restored to the Advanced Test Reactor (ATR) at Idaho National Laboratory (INL). The general design and operating principles of this system were patterned after the hydraulic rabbit at Oak Ridge National Laboratory's (ORNL) High Flux Isotope Reactor (HFIR), which has operated successfully for many years. Using primary coolant as the motive medium the HSIS system is designed to simultaneously transport fourteen shuttle capsules, each 16 mm OD x 57 mm long, to and from the B-7 position of the reactor. The B-7 position is one of the higher flux positions in the reactor with typical thermal and fast (>1 Mev) fluxes of 2.8E+14 n/cm2/sec and 1.9E+14 n/cm2/sec respectively. The available space inside each shuttle is approximately 14 mm diameter x 50 mm long. The shuttle containers are made from titanium which was selected for its low neutron activation properties and durability. Shuttles can be irradiated for time periods ranging from a few minutes to several months. The Send and Receive Station (SRS) for the HSIS is located 2.5 m deep in the ATR canal which allows irradiated shuttles to be easily moved from the SRS to a wet loaded cask, or transport pig. The HSIS system first irradiated (empty) shuttles in September 2009 and has since completed a Readiness Assessment in November 2009. The HSIS is a key component of the ATR National Scientific User Facility (NSUF) operated by Battelle Energy Alliance, LLC and is available to a wide variety of university researchers for nuclear fuels and materials experiments as well as medical isotope research and production.

  17. AGR-3/4 Final Data Qualification Report for ATR Cycles 151A through 155B-1

    Energy Technology Data Exchange (ETDEWEB)

    Pham, Binh T. [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2015-03-01

    This report provides the qualification status of experimental data for the entire Advanced Gas Reactor 3/4 (AGR 3/4) fuel irradiation. AGR-3/4 is the third in a series of planned irradiation experiments conducted in the Advanced Test Reactor (ATR) at Idaho National Laboratory (INL) for the AGR Fuel Development and Qualification Program, which supports development of the advanced reactor technology under the INL ART Technology Development Office (TDO). The main objective of AGR-3/4 irradiation is to provide a known source of fission products for subsequent transport through compact matrix and structural graphite materials due to the presence of designed-to-fail fuel particles. Full power irradiation of the AGR 3/4 test began on December 14, 2011 (ATR Cycle 151A), and was completed on April 12, 2014 (end of ATR Cycle 155B) after 369.1 effective full power days of irradiation. The AGR-3/4 test was in the reactor core for eight of the ten ATR cycles between 151A and 155B. During the unplanned outage cycle, 153A, the experiment was removed from the ATR northeast flux trap (NEFT) location and stored in the ATR canal. This was to prevent overheating of fuel compacts due to higher than normal ATR power during the subsequent Powered Axial Locator Mechanism cycle, 153B. The AGR 3/4 test was inserted back into the ATR NEFT location during the outage of ATR Cycle 154A on April 26, 2013. Therefore, the AGR-3/4 irradiation data received during these 2 cycles (153A and 153B) are irrelevant and their qualification status isnot included in this report. Additionally, during ATR Cycle 152A the ATR core ran at low power for a short enough duration that the irradiation data are not used for physics and thermal calculations. However, the qualification status of irradiation data for this cycle is still covered in this report. As a result, this report includes data from 8 ATR Cycles: 151A, 151B, 152A, 152B, 154A, 154B, 155A, and 155B, as recorded in the Nuclear Data Management and

  18. Radar automatic target recognition (ATR) and non-cooperative target recognition (NCTR)

    CERN Document Server

    Blacknell, David

    2013-01-01

    The ability to detect and locate targets by day or night, over wide areas, regardless of weather conditions has long made radar a key sensor in many military and civil applications. However, the ability to automatically and reliably distinguish different targets represents a difficult challenge. Radar Automatic Target Recognition (ATR) and Non-Cooperative Target Recognition (NCTR) captures material presented in the NATO SET-172 lecture series to provide an overview of the state-of-the-art and continuing challenges of radar target recognition. Topics covered include the problem as applied to th

  19. Structure-Activity Relations In Enzymes: An Application Of IR-ATR Modulation Spectroscopy

    Science.gov (United States)

    Fringeli, Urs P.; Ahlstrom, Peter; Vincenz, Claudius; Fringeli, Marianna

    1985-12-01

    Relations between structure and specific activity in immobilized acetylcholinesterase (ACNE) have been studied by means of pH- and Ca++-modulation technique combined with attenuated total reflection (ATR) infrared (IR) spectroscopy and enzyme activity measurement. Periodic modulation of pH and Ca++-concentration enabled a periodic on-off switching of about 40% of the total enzyme activity. It was found that about 0.5 to 1% of the amino acids were involved in this process. These 15 to 30 amino acids assumed antiparallel pleated sheet structure in the inhibited state and random and/or helical structure in the activated state.

  20. FTIR-ATR monitoring and SEC/RI/MALLS characterization of ATRP synthesized hyperbranched polyacrylates

    OpenAIRE

    Gonçalves, Miguel; Pinto, Virgínia; Dias, Rolando; Costa, Mário Rui

    2010-01-01

    This work reports the synthesis at 1 L scale of hyperbranched polyacrylates based upon acrylate/diacrylate monomers such as n-butyl acrylate (nBA)/1,6-hexanediol diacrylate (HDDA) and using atom transfer radical polymerization (ATRP). A FTIR-ATR immersion probe was used to monitor the polymerization reaction. The dynamics of the build-up of polymer structure was studied by off-line analysis of samples at different reaction times by size exclusion chromatography (SEC) with detection of refract...

  1. Registration of heavy metal ions and pesticides with ATR planar waveguide enzyme sensors

    Science.gov (United States)

    Nabok, Alexei; Haron, Saharudin; Ray, Asim

    2004-11-01

    The proposed novel type of enzyme optical sensors is based on a combination of SiO2/Si3N4/SiO2 planar waveguide ATR (attenuated total reflection) transducer, fabricated by standard silicon planar technology, with the composite polyelectrolyte self-assembled coating containing both organic chromophores and enzyme molecules. Such devices were deployed to monitor typical industrial and agricultural water pollutants, such as heavy metal ions and pesticides, acting as inhibitors of enzyme reactions. The sensitivity of registration of these pollutants in the range of 1 ppb was achieved. The use of different enzymes in the sensitive membrane provides a background for pattern recognition of the above pollutants.

  2. Investigation on the adsorption characteristics of sodium benzoate and taurine on gold nanoparticle film by ATR-FTIR spectroscopy

    Science.gov (United States)

    Kumar, Naveen; Thomas, S.; Tokas, R. B.; Kshirsagar, R. J.

    2014-01-01

    Fourier transform infrared (FTIR) spectroscopic studies of sodium benzoate and taurine adsorbed on gold nanoparticle (AuNp) film on silanised glass slides have been studied by attenuated total reflection technique (ATR). The surface morphology of the AuNp films has been measured by Atomic Force Microscopy. The ATR spectra of sodium benzoate and taurine deposited on AuNp film are compared with ATR spectra of their powdered bulk samples. A new red-shifted band appeared along with the symmetric and asymmetric stretches of carboxylate group of sodium benzoate leading to a broadening of the above peaks. Similar behavior is also seen in the case of symmetric and asymmetric stretches of sulphonate group of taurine. The results indicate presence of both chemisorbed and physisorbed layers of both sodium benzoate and taurine on the AuNp film with bottom layer chemically bound to AuNp through carboxylate and sulphonate groups respectively.

  3. Measured thermal and fast neutron fluence rates ATR Cycle 101-B, October 11, 1993--November 27, 1993

    International Nuclear Information System (INIS)

    This report contains the thermal (2200 m/s) and fast (E>lMeV) neutron fluence rate data for ATR Cycle 101-B which were measured by the Radiation Measurements Laboratory (RML) as requested by the Power Reactor Programs (ATR Experiments) Radiation Measurements Work Order. This report contains fluence rate values corresponding to the particular elevations (relative to the 80 ft. core elevation) where the measurements were taken. The data in this report consists of (1) a table of the ATR power history and distribution, (2) a hard copy listing of all thermal and fast neutron fluence rates, (3) plots of both the thermal and fast neutron fluence rates, and (4) a magnetic record (3.5 inch diskette) containing a listing of only the fast neutron fluence rates, their assigned elevations proper header identification of all monitor positions contained herein

  4. Analysis code for large rupture accidents in ATR. SENHOR/FLOOD/HEATUP

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-08-01

    In the evaluation of thermo-hydraulic transient change, the behavior of core reflooding and the transient change of fuel temperature in the events which are classified in large rupture accidents of reactor coolant loss, that is the safety evaluation event of the ATR, the analysis codes for thermo-hydraulic transient change at the time of large rupture SENHOR, for core reflooding characteristics FLOOD and for fuel temperature HEATUP are used, respectively. The analysis code system for loss of coolant accident comprises the analysis code for thermo-hydraulic transient change at the time of medium and small ruptures LOTRAC in addition to the above three codes. Based on the changes with time lapse of reactor thermal output and steam drum pressure obtained by the SENHOR, average reflooding rate is analyzed by the FLOOD, and the time of starting the turnaround of fuel cladding tube temperature and the heat transfer rate after the turnaround are determined. Based on these data, the detailed temperature change of fuel elements is analyzed by the HEATUP, and the highest temperature and the amount of oxidation of fuel cladding tubes are determined. The SENHOR code, the FLOOD code and the HEATUP code and various models for these codes are explained. The example of evaluation and the sensitivity analysis of the ATR plant are reported in the Appendix. (K.I.)

  5. In-column ATR-FTIR spectroscopy to monitor affinity chromatography purification of monoclonal antibodies

    Science.gov (United States)

    Boulet-Audet, Maxime; Kazarian, Sergei G.; Byrne, Bernadette

    2016-07-01

    In recent years many monoclonal antibodies (mAb) have entered the biotherapeutics market, offering new treatments for chronic and life-threatening diseases. Protein A resin captures monoclonal antibody (mAb) effectively, but the binding capacity decays over repeated purification cycles. On an industrial scale, replacing fouled Protein A affinity chromatography resin accounts for a large proportion of the raw material cost. Cleaning-in-place (CIP) procedures were developed to extend Protein A resin lifespan, but chromatograms cannot reliably quantify any remaining contaminants over repeated cycles. To study resin fouling in situ, we coupled affinity chromatography and Fourier transform infrared (FTIR) spectroscopy for the first time, by embedding an attenuated total reflection (ATR) sensor inside a micro-scale column while measuring the UV 280 nm and conductivity. Our approach quantified the in-column protein concentration in the resin bed and determined protein conformation. Our results show that Protein A ligand leached during CIP. We also found that host cell proteins bound to the Protein A resin even more strongly than mAbs and that typical CIP conditions do not remove all fouling contaminants. The insights derived from in-column ATR-FTIR spectroscopic monitoring could contribute to mAb purification quality assurance as well as guide the development of more effective CIP conditions to optimise resin lifespan.

  6. Independent Review of AFC 2A, 2B, and 2E ATR Irradiation Tests

    Energy Technology Data Exchange (ETDEWEB)

    M. Cappiello; R. Hobbins; K. Penny; L. Walters

    2014-01-01

    As part of the Department of Energy Advanced Fuel Cycle program, a series of fuels development irradiation tests have been performed in the Advanced Test Reactor (ATR) at the Idaho National Laboratory. These tests are providing excellent data for advanced fuels development. The program is focused on the transmutation of higher actinides which best can be accomplished in a sodium-cooled fast reactor. Because a fast test reactor is no longer available in the US, a special test vehicle is used to achieve near-prototypic fast reactor conditions (neutron spectra and temperature) for use in ATR (a water-cooled thermal reactor). As part of the testing program, there were many successful tests of advanced fuels including metals and ceramics. Recently however, there have been three experimental campaigns using metal fuels that experienced failure during irradiation. At the request of the program, an independent review committee was convened to review the post-test analyses performed by the fuels development team, to assess the conclusions of the team for the cause of the failures, to assess the adequacy and completeness of the analyses, to identify issues that were missed, and to make recommendations for improvements in the design and operation of future tests. Although there is some difference of opinion, the review committee largely agreed with the conclusions of the fuel development team regarding the cause of the failures. For the most part, the analyses that support the conclusions are sufficient.

  7. ATR-FTIR microscopy in mapping mode for the study of verdigris and its secondary products

    Science.gov (United States)

    Prati, S.; Bonacini, I.; Sciutto, G.; Genty-Vincent, A.; Cotte, M.; Eveno, M.; Menu, M.; Mazzeo, R.

    2016-01-01

    To study degradation processes occurring on painting materials, the use of high-resolution micro-analytical techniques is highly requested since it provides a detailed identification and localisation of both the original and deteriorated ingredients. Among the various pigments recently studied, the characterisation of verdigris has received a major interest. This pigment has not a unique chemical formula, but its composition depends on the recipe employed for its manufacturing. Moreover, verdigris paints are not stable and are subject to a colour change from blue-green to green, which occurs in the first few months after the application. In this paper, we focused our attention on the use of ATR-FTIR mapping as a useful method to identify verdigris secondary products and pathways. Several mock-ups and real samples have been analysed, and the correlation among the detected compounds and their spatial location, obtained by the application of ATR-FTIR microscopy in mapping mode, allowed formulating some hypotheses on the degradation pattern of verdigris, which may feed the discussion on the transformation and stability of this pigment. From an analytical point of view, we showed how FTIR mapping approaches may be extremely useful both for the identification of compounds in complex matrix in which single spectra may limit the exhaustive characterisations due to bands overlapping and for the study of degradation pathways by taking into consideration the relative distribution of degradation products.

  8. Rapid detection of melamine adulteration in dairy milk by SB-ATR-Fourier transform infrared spectroscopy.

    Science.gov (United States)

    Jawaid, Sana; Talpur, Farah N; Sherazi, S T H; Nizamani, Shafi M; Khaskheli, Abid A

    2013-12-01

    Melamine is a nitrogenous chemical substance used principally as a starting material for the manufacture of synthetic resins. Due to its very high proportion of nitrogen melamine has been added illegitimately to foods and feeds to increase the measured protein content, which determines the value of the product. These issues prompted private as well as governmental laboratories to develop methods for the analysis of melamine in a wide variety of food products and ingredients. Owing to this fact present study is aimed to use single bounce attenuated total reflectance (SB-ATR) Fourier transform infrared spectroscopy (FTIR) method as an effective rapid tool for the detection and quantification of melamine in milk (liquid and powder). Partial least-squares (PLS) models were established for correlating spectral data to melamine concentration with R(2)>0.99, and RMSEC 0.370. Linear calibration curves were obtained over the calibration range of 25-0.0625%. The LOD and LOQ of the method was 0.00025% (2.5 ppm) and 0.0015% (15 ppm) respectively. Proposed SB-ATR-FTIR method requires little or no sample preparation with an assay time of 1-2 min. PMID:23871060

  9. DBC1 phosphorylation by ATM/ATR inhibits SIRT1 deacetylase in response to DNA damage

    Institute of Scientific and Technical Information of China (English)

    Laura Zannini; Giacomo Buscemi; Ja-Eun Kim; Enrico Fontanella; Domenico Delia

    2012-01-01

    Human DBC1 (deleted in breast cancer-1; KIAA1967) is a nuclear protein that,in response to DNA damage,competitively inhibits the NAD+-dependent deacetylase SIRT1,a regulator of p53 apoptotic functions in response to genotoxic stress.DBC1 depletion in human cells increases SIRT1 activity,resulting in the deacetylation of p53 and protection from apoptosis.However,the mechanisms regulating this process have not yet been determined.Here,we report that,in human cell lines,DNA damage triggered the phosphorylation of DBC1 on Thr454 by ATM (ataxia telangiectasia-mutated) and ATR (ataxia telangiectasia and Rad3-related)kinases.Phosphorylated DBC1 bound to and inhibited SIRT1,resulting in the dissociation of the SIRT1-p53 complex and stimulating p53 acetylation and p53-dependent cell death.Indeed,DBC1-mediated genotoxicity,which was shown in knockdown experiments to be dependent on SIRT1 and p53 expression,was defective in cells expressing the phospho-mutant DBC1T454A.This study describes the first post-translational modification of DBC1 and provides new mechanistic insight linking ATM/ATR to the DBC1-SIRT1-p53 apoptotic axis triggered by DNA damage.

  10. Characterization of Printing Inks Using DART-Q-TOF-MS and Attenuated Total Reflectance (ATR) FTIR.

    Science.gov (United States)

    Williamson, Rhett; Raeva, Anna; Almirall, Jose R

    2016-05-01

    The rise in improved and widely accessible printing technology has resulted in an interest to develop rapid and minimally destructive chemical analytical techniques that can characterize printing inks for forensic document analysis. Chemical characterization of printing inks allows for both discrimination of inks originating from different sources and the association of inks originating from the same source. Direct analysis in real-time mass spectrometry (DART-MS) and attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR) were used in tandem to analyze four different classes of printing inks: inkjets, toners, offset, and intaglio. A total of 319 samples or ~ 80 samples from each class were analyzed directly on a paper substrate using the two methods. DART-MS was found to characterize the semi-volatile polymeric vehicle components, while ATR-FTIR provided chemical information associated with the bulk components of these inks. Complimentary data results in improved discrimination when both techniques are used in succession resulting in >96% discrimination for all toners, 95% for all inkjets, >92% for all offset, and >54% for all intaglio inks. PMID:27122410

  11. New particle formation events measured on board the ATR-42 aircraft during the EUCAARI campaign

    Directory of Open Access Journals (Sweden)

    S. Crumeyrolle

    2010-07-01

    Full Text Available Aerosol properties were studied during an intensive airborne measurement campaign that took place at Rotterdam in Netherlands in May 2008 within the framework of the European Aerosol Cloud Climate and Air Quality Interactions project (EUCAARI. The objective of this study is to illustrate seven events of new particle formation (NPF observed with two Condensation Particle Counters (CPCs operated on board the ATR-42 research aircraft in airsectors around Rotterdam, and to provide information on the spatial extent of the new particle formation phenomenon based on 1-s resolution measurements of ultra-fine particle (in the size range 3–10 nm diameter, denoted N3-10 hereafter concentrations. The results show that particle production occurred under the influence of different air mass origins, at different day times and over the North Sea as well as over the continent. The number concentration of freshly nucleated particles (N3-10 varied between 5000 and 100 000 cm−3 within the boundary layer (BL. Furthermore the vertical extension for all nucleation events observed on the ATR-42 never exceeded the upper limit of the BL. The horizontal extent of N3-10 could not be delimited due to inflexible flight plans which could not be modified to accommodate real-time results. However, the NPF events were observed over geographically large areas; typically the horizontal extension was about 100 km and larger.

  12. Diesel fuel processor for PEM fuel cells: Two possible alternatives (ATR versus SR)

    Science.gov (United States)

    Cutillo, A.; Specchia, S.; Antonini, M.; Saracco, G.; Specchia, V.

    There are large efforts in exploring the on-board reforming technologies, which would avoid the actual lack of hydrogen infrastructure and related safety issues. From this view point, the present work deals with the comparison between two different 10 kW e fuel processors (FP) systems for the production of hydrogen-rich fuel gas starting from diesel oil, based respectively on autothermal (ATR) and steam-reforming (SR) process and related CO clean-up technologies; the obtained hydrogen rich gas is fed to the PEMFC stack of an auxiliary power unit (APU). Based on a series of simulations with Matlab/Simulink, the two systems were compared in terms of FP and APU efficiency, hydrogen concentration fed to the FC, water balance and process scheme complexity. Notwithstanding a slightly higher process scheme complexity and a slightly more difficult water recovery, the FP based on the SR scheme, as compared to the ATR one, shows higher efficiency and larger hydrogen concentration for the stream fed to the PEMFC anode, which represent key issues for auxiliary power generation based on FCs as compared, e.g. to alternators.

  13. Gastritis crónica atrófica: mecanismos patogénicos por hipersensibilidad celular

    OpenAIRE

    Rosemary Recavarren Asencios; Sixto Recavarren Arce

    2002-01-01

    La Gastritis Crónica Atrófica, de alta incidencia en la infección por Helicobacter pylori, no ha tenido hasta hoy mecanismos patogénicos establecidos. La Gastritis por Helicobacter pylori, claramente relacionada a la Gastritis Crónica Activa Superficial, no ha encontrado mecanismos que la conecten con la Gastritis Crónica Atrófica. Hasta hace poco, eran consideradas por algunos autores como lesiones independientes. En el presente trabajo, se estudiaron 42 biopsias gástricas antrales o corpora...

  14. NON-DESTRUCTIVE TESTS OF LOCK TONGUES USED IN ATR-72 AIRCRAFT LANDING GEAR BASED ON MAGNETIC METHOD

    Directory of Open Access Journals (Sweden)

    Mirosław Malec

    2013-12-01

    Full Text Available The purpose of this work is to highlight the opportunities of using and analyzing process progression of Non-destructive Testing in aeronautical industries and technologies. This paper concentrates on magnetic-fluorescent method, which is used to showcase the practical test of lock tongue installed in ATR-72 aircraft landing gear.

  15. NON-DESTRUCTIVE TESTS OF LOCK TONGUES USED IN ATR-72 AIRCRAFT LANDING GEAR BASED ON MAGNETIC METHOD

    OpenAIRE

    Mirosław Malec; Tomasz Cieplak; Sławomir Walczuk

    2013-01-01

    The purpose of this work is to highlight the opportunities of using and analyzing process progression of Non-destructive Testing in aeronautical industries and technologies. This paper concentrates on magnetic-fluorescent method, which is used to showcase the practical test of lock tongue installed in ATR-72 aircraft landing gear.

  16. Quantitative in-situ ATR-FTIR studies on the selective interaction of polyelectrolyte multilayers with protein mixtures

    Czech Academy of Sciences Publication Activity Database

    Müller, M.; Bohatá, Karolína; Ouyang, W.; Kessler, B.; Pientka, Zbyněk; Brynda, Eduard

    Graz : Austrian Centre for Electron MIcroscopy and Nanoanalysis, 2007. S.26. [European Symposium on Polymer Spectroscopy /17./. 09.9.2007-12.09.2007, Seggauberg Leibnitz] Institutional research plan: CEZ:AV0Z40500505 Keywords : polyelectrolyte multilayers * ATR-FTIR studies Subject RIV: CD - Macromolecular Chemistry

  17. Adsorption of poly(ethylene oxide)-block-polylactide copolymers on polylactide as studied by ATR-FTIR spectroscopy

    Czech Academy of Sciences Publication Activity Database

    Popelka, Štěpán; Machová, Luďka; Rypáček, František

    2007-01-01

    Roč. 308, č. 2 (2007), s. 291-299. ISSN 0021-9797 R&D Projects: GA AV ČR IAA4050202 Institutional research pla n: CEZ:AV0Z40500505 Keywords : ATR-FTIR spectroscopy * copolymer adsorption * poly(ethylene oxide) Subject RIV: CD - Macromolecular Chemistry Impact factor: 2.309, year: 2007

  18. Unidirectional excitation of graphene plasmon in attenuated total reflection (ATR) configuration

    Energy Technology Data Exchange (ETDEWEB)

    Dai, Wei [Hubei University of Education, Wuhan (China). School of Physics and Mechanical and Electrical Engineering; Wu, Yue-Chao [Nanyang Technological University, Singapore (Singapore). Div. of Physics and Applied Physics; Liu, Fang-Li [Maryland Univ., College Park, MD (United States). Joint Quantum Institute

    2016-08-01

    Graphene plasmon has been attracting interests from both theoretical and experimental research due to its gate tunability and potential applications in the terahertz frequency range. Here, we propose an effective scheme to unidirectionally excite the graphene plasmon by exploiting magneto-optical materials in the famous attenuated total reflection (ATR) configuration. We show that the graphene plasmon dispersion relation in such a device is asymmetric in different exciting directions, thus making it possible to couple the incident light unidirectionally to the propagating plasmon. The split of absorption spectrum of graphene clearly indicates that under a magnetic field for one single frequency, graphene plasmon can only be excited in one direction. The possible gate tunablity of excitation direction and the further application of the proposed scheme, such as optical isolator, also are discussed.

  19. Application of ATR-FTIR spectroscopy in quantitative analysis of deuterium in basic solutions

    International Nuclear Information System (INIS)

    A method to measure the deuterium concentration in basic solutions, using Attenuated Total Reflection Fourier Transformed Infrared Spectroscopy (ATR-FTIR) is described. Deuterium quantification is based on the O-D bond stretching peak. A calibration curve is drawn, representing the peak intensity versus the deuterium percentage in a neutral solution. No calibration curve can be obtained with basic solutions, because of the strong absorbance due to hydroxide ions. Thus, an acidification is necessary prior to the analysis of a basic solution. The deuterium content of this acid solution is then measured. As we know the dilution caused by the acid addition, we can calculate the deuterium content of the initial basic solution. The relative uncertainty of this method is + or - 2%. (authors)

  20. Synergistic potentiation of (-)-lomaiviticin A cytotoxicity by the ATR inhibitor VE-821.

    Science.gov (United States)

    Colis, Laureen C; Herzon, Seth B

    2016-07-01

    (-)-Lomaiviticin A (1) is a cytotoxic bacterial metabolite that induces double-strand breaks in DNA. Here we show that the cytotoxicity of (-)-lomaiviticin A (1) is synergistically potentiated in the presence of VE-821 (7), an inhibitor of ataxia telangiectasia and Rad3-related protein (ATR). While 0.5nM 1 or 10μM 7 alone are non-lethal to K562 cells, co-incubation of the two leads to high levels of cell kill (81% and 94% after 24 and 48h, respectively). Mechanistic data indicate that cells treated with 1 and 7 suffer extensive DNA double-strand breaks and apoptosis. These data suggest combinations of 1 and 7 may be a valuable chemotherapeutic strategy. PMID:27177826

  1. Unidirectional Excitation of Graphene Plasmon in Attenuated Total Reflection (ATR) Configuration

    Science.gov (United States)

    Dai, Wei; Wu, Yue-Chao; Liu, Fang-Li

    2016-04-01

    Graphene plasmon has been attracting interests from both theoretical and experimental research due to its gate tunability and potential applications in the terahertz frequency range. Here, we propose an effective scheme to unidirectionally excite the graphene plasmon by exploiting magneto-optical materials in the famous attenuated total reflection (ATR) configuration. We show that the graphene plasmon dispersion relation in such a device is asymmetric in different exciting directions, thus making it possible to couple the incident light unidirectionally to the propagating plasmon. The split of absorption spectrum of graphene clearly indicates that under a magnetic field for one single frequency, graphene plasmon can only be excited in one direction. The possible gate tunablity of excitation direction and the further application of the proposed scheme, such as optical isolator, also are discussed.

  2. Study of consumer fireworks post-blast residues by ATR-FTIR.

    Science.gov (United States)

    Martín-Alberca, Carlos; Zapata, Félix; Carrascosa, Héctor; Ortega-Ojeda, Fernando E; García-Ruiz, Carmen

    2016-03-01

    Specific analytical procedures are requested for the forensic analysis of pre- and post-blast consumer firework samples, which present significant challenges. Up to date, vibrational spectroscopic techniques such as Fourier transform infrared spectroscopy (FTIR) have not been tested for the analysis of post-blast residues in spite of their interesting strengths for the forensic field. Therefore, this work proposes a simple and fast procedure for the sampling and analysis of consumer firework post-blast residues by a portable FTIR instrument with an Attenuated Total Reflection (ATR) accessory. In addition, the post-blast residues spectra of several consumer fireworks were studied in order to achieve the identification of their original chemical compositions. Hence, this work analysed 22 standard reagents usually employed to make consumer fireworks, or because they are related to their combustion products. Then, 5 different consumer fireworks were exploded, and their residues were sampled with dry cotton swabs and directly analysed by ATR-FTIR. In addition, their pre-blast fuses and charges were also analysed in order to stablish a proper comparison. As a result, the identification of the original chemical compositions of the post-blast samples was obtained. Some of the compounds found were potassium chlorate, barium nitrate, potassium nitrate, potassium perchlorate or charcoal. An additional study involving chemometric tools found that the results might greatly depend on the swab head type used for the sampling, and its sampling efficiency. The proposed procedure could be used as a complementary technique for the analysis of consumer fireworks post-blast residues. PMID:26717839

  3. Analysis of H2O in silicate glass using attenuated total reflectance (ATR) micro-FTIR spectroscopy

    Science.gov (United States)

    Lowenstern, Jacob B.; Pitcher, Bradley W.

    2013-01-01

    We present a calibration for attenuated total reflectance (ATR) micro-FTIR for analysis of H2O in hydrous glass. A Ge ATR accessory was used to measure evanescent wave absorption by H2O within hydrous rhyolite and other standards. Absorbance at 3450 cm−1 (representing total H2O or H2Ot) and 1630 cm−1 (molecular H2O or H2Om) showed high correlation with measured H2O in the glasses as determined by transmission FTIR spectroscopy and manometry. For rhyolite, wt%H2O=245(±9)×A3450-0.22(±0.03) and wt%H2Om=235(±11)×A1630-0.20(±0.03) where A3450 and A1630 represent the ATR absorption at the relevant infrared wavelengths. The calibration permits determination of volatiles in singly polished glass samples with spot size down to ~5 μm (for H2O-rich samples) and detection limits of ~0.1 wt% H2O. Basaltic, basaltic andesite and dacitic glasses of known H2O concentrations fall along a density-adjusted calibration, indicating that ATR is relatively insensitive to glass composition, at least for calc-alkaline glasses. The following equation allows quantification of H2O in silicate glasses that range in composition from basalt to rhyolite: wt%H2O=(ω×A3450/ρ)+b where ω = 550 ± 21, b = −0.19 ± 0.03, ρ = density, in g/cm3, and A3450 is the ATR absorbance at 3450 cm−1. The ATR micro-FTIR technique is less sensitive than transmission FTIR, but requires only a singly polished sample for quantitative results, thus minimizing time for sample preparation. Compared with specular reflectance, it is more sensitive and better suited for imaging of H2O variations in heterogeneous samples such as melt inclusions. One drawback is that the technique can damage fragile samples and we therefore recommend mounting of unknowns in epoxy prior to polishing. Our calibration should hold for any Ge ATR crystals with the same incident angle (31°). Use of a different crystal type or geometry would require measurement of several H2O-bearing standards to provide a crystal

  4. Rapid determination of free fatty acids in poultry feed lipid extracts by SB-ATR FTIR spectroscopy.

    Science.gov (United States)

    Sherazi, S T H; Mahesar, S A; Bhanger, M I; van de Voort, F R; Sedman, J

    2007-06-27

    A simple, rapid, and reproducible method has been developed for the quantitative determination of free fatty acid (FFA) content in lipids extracted from poultry feeds by Fourier transform infrared (FTIR) spectroscopy with the use of a single-bounce attenuated total reflectance (SB-ATR) accessory. An FTIR calibration curve was prepared by gravimetrically adding oleic acid (15-37%) to pure refined, bleached, and deodorized (RBD) canola oil and measuring the area of the COOH absorption band at 1710 cm-1. The oil from each of 12 poultry feed formulations was extracted using conventional Soxhlet extraction, and after evaporation of the solvent, the FFA content was determined by the conventional AOCS titrimetric procedure and by the SB-ATR/FTIR method. The SB-ATR/FTIR FFA predictions were related to those determined by the AOCS titrimetric method by linear regression, producing an R value of 0.999 and a SD of +/-0.28% FFA. Time-course spectra collected as lipids extracted into hexane indicated that a 15 min extraction was adequate to obtain a representative sample for FFA determination, with further extraction resulting in little, if any, change in the proportion of FFA in the lipid extract. Only a small volume of the hexane extract ( approximately 20 mL) yielded sufficient material for the SB-ATR/FTIR analysis. Thus, by shortening the extraction time and taking a small sample so as to reduce solvent removal time, the SB-ATR/FTIR procedure provides a very simple and rapid means of determining the FFA content of poultry feed lipids. PMID:17530766

  5. A testbed for architecture and fidelity trade studies in the Bayesian decision-level fusion of ATR products

    Science.gov (United States)

    Erickson, Kyle J.; Ross, Timothy D.

    2007-04-01

    Decision-level fusion is an appealing extension to automatic/assisted target recognition (ATR) as it is a low-bandwidth technique bolstered by a strong theoretical foundation that requires no modification of the source algorithms. Despite the relative simplicity of decision-level fusion, there are many options for fusion application and fusion algorithm specifications. This paper describes a tool that allows trade studies and optimizations across these many options, by feeding an actual fusion algorithm via models of the system environment. Models and fusion algorithms can be specified and then exercised many times, with accumulated results used to compute performance metrics such as probability of correct identification. Performance differences between the best of the contributing sources and the fused result constitute examples of "gain." The tool, constructed as part of the Fusion for Identifying Targets Experiment (FITE) within the Air Force Research Laboratory (AFRL) Sensors Directorate ATR Thrust, finds its main use in examining the relationships among conditions affecting the target, prior information, fusion algorithm complexity, and fusion gain. ATR as an unsolved problem provides the main challenges to fusion in its high cost and relative scarcity of training data, its variability in application, the inability to produce truly random samples, and its sensitivity to context. This paper summarizes the mathematics underlying decision-level fusion in the ATR domain and describes a MATLAB-based architecture for exploring the trade space thus defined. Specific dimensions within this trade space are delineated, providing the raw material necessary to define experiments suitable for multi-look and multi-sensor ATR systems.

  6. Quantitative Analysis of the Relative Transcript Levels of ABC Transporter Atr Genes in Aspergillus nidulans by Real-Time Reverse Transcription-PCR Assay

    Science.gov (United States)

    Pizeta Semighini, Camile; Marins, Mozart; Goldman, Maria Helena S.; Goldman, Gustavo Henrique

    2002-01-01

    The development of assays for quantitative analysis of the relative transcript levels of ABC transporter genes by real-time reverse transcription-PCR (RT-PCR) might provide important information about multidrug resistance in filamentous fungi. Here, we evaluate the potential of real-time RT-PCR to quantify the relative transcript levels of ABC transporter Atr genes from Aspergillus nidulans. The AtrA to AtrD genes showed different and higher levels in the presence of structurally unrelated drugs, such as camptothecin, imazalil, itraconazole, hygromycin, and 4-nitroquinoline oxide. We also verified the relative transcript levels of the Atr genes in the A. nidulans imazalil-resistant mutants. These genes displayed a very complex pattern in different ima genetic backgrounds. The imaB mutant has higher basal transcript levels of AtrB and -D than those of the wild-type strain. The levels of these two genes are comparable when the imaB mutant is grown in the presence and absence of imazalil. The imaC, -D, and -H mutants have higher basal levels of AtrA than that of the wild type. The same behavior is observed for the relative transcript levels of AtrB in the imaG mutant background. PMID:11872487

  7. Defining the Contribution of MC1R Physiological Ligands to ATR Phosphorylation at Ser435, a Predictor of DNA Repair in Melanocytes.

    Science.gov (United States)

    Jarrett, Stuart G; Wolf Horrell, Erin M; Boulanger, Mary C; D'Orazio, John A

    2015-12-01

    The melanocortin 1 receptor (MC1R), a GS-coupled receptor that signals through cAMP and protein kinase A (PKA), regulates pigmentation, adaptive tanning, and melanoma resistance. MC1R-cAMP signaling promotes PKA-mediated phosphorylation of ataxia telangiectasia and rad3-related (ATR) at Ser435 (ATR-pS435), a modification that enhances nucleotide excision repair (NER) by facilitating recruitment of the XPA protein to sites of UV-induced DNA damage. High-throughput methods were developed to quantify ATR-pS435, measure XPA-photodamage interactions, and assess NER function. We report that melanocyte-stimulating hormone (α-MSH) or ACTH induce ATR-pS435, enhance XPA's association with UV-damaged DNA and optimize melanocytic NER. In contrast, MC1R antagonists agouti signaling protein (ASIP) or human β-defensin 3 (HBD3) interfere with ATR-pS435 generation, impair the XPA-DNA interaction, and reduce DNA repair. Although ASIP and HBD3 each blocked α-MSH-mediated induction of the signaling pathway, only ASIP depleted basal ATR-pS435. Our findings confirm that ASIP diminishes agonist-independent MC1R basal signaling whereas HBD3 is a neutral MC1R antagonist that blocks activation by melanocortins. Furthermore, our data suggest that ATR-pS435 may be a useful biomarker for the DNA repair-deficient MC1R phenotype. PMID:26168232

  8. Pembuatan Standard Operating Procedure (SOP Service Desk Berdasarkan Kerangka Kerja Itil V3 dengan Menggunakan Metode Analisis Gap Layanan (Studi Kasus: PT. XYZ , Tangerang

    Directory of Open Access Journals (Sweden)

    Annisa Rachmi

    2014-09-01

    Full Text Available Penggunaan Teknologi Informasi di banyak perusahaan telah menjadi satu hal penting dalam meningkatkan efektifitas dan efisiensi operasional bisnis yang mendukung tercapainya tujuan perusahaan, termasuk juga PT XYZ. Unit fungsional service desk sangat dibutuhkan oleh PT XYZ dalam mendukung operasional TI dan menangani permasalahan yang muncul serta memonitor terkait penggunaan TI yang ada di dalam perusahaan. Adanya kebutuhan PT XYZ untuk menjadikan service desk menjadi unit yang dapat berjalan dengan baik sesuai dengan fungsinya, menunjukkan bahwa perlunya penerapan tata kelola TI untuk mengatur dan mengelola aktivitas service desk. Salah satu tata kelola TI yang dimaksud adalah berupa prosedur kerja. Kerangka kerja Information Technology Infrastructure Library (ITIL merupakan suatu best practice yang bertujuan secara berkelanjutan meningkatkan efisiensi operasional TI. Perancangan dan implementasi service desk berdasarkan kerangka kerja ITIL V3 di PT XYZ diperlukan dalam upaya meningkatkan layanan TI dan mengatasi masalah yang ada saat ini. Pembuatan SOP ini diinisialisasi dengan menggunakan metode analisis gap, proses-proses yang dimuat ke dalam SOP merupakan hasil analisis kesenjangan antara kondisi kekinian service desk PT XYZ dengan kondisi ideal service desk framework ITIL.

  9. EVALUASI KEAMANAN INFORMASI PADA PTI PDAM TIRTA MOEDAL KOTA SEMARANG BERDASARKAN INDEKS KEAMANAN INFORMASI SNI ISO/IEC 27001:2009

    Directory of Open Access Journals (Sweden)

    Diah Restu Wardani

    2015-10-01

    Full Text Available Adanya rencana untuk meningkatkan keamanan informasi sesuai dengan Standar Nasional Indonesia (SNI. Selain rencana tersebut, ditemukan kurangnya kesadaran dari masing-masing staff PTI PDAM Tirta Moedal Kota Semarang terkait dengan keamanan informasi menyebabkan terjadinya berbagai masalah salah satunya penyalahgunaan wewenang yang dilakukan oleh staff PTI yaitu dengan mengubah sistem operasi yang telah ditetapkan oleh PTI PDAM dan kejadian tersebut berdampak pada proses bisnis. Ditemukan pula bahwa kurangnya pengamanan pada ruang server yang ada di divisi PTI. Tujuan dari penelitian ini adalah untuk mengevaluasi tingkat kelengkapan dan tingkat kematangan keamanan informasi pada divisi PTI serta memberikan rekomendasi perbaikan untuk meningkatkan tingkat kelengkapan dan tingkat kematangan keamanan informasi. Dari hasil studi dokumen, wawancara, dan kuesioner berdasarkan Indeks Keamanan Informasi SNI ISO/IEC 27001:2009 dihasilkan tingkat kelengkapan keamanan informasi sebesar 325 dan tingkat kematangan berada pada tingkat I+ dimana sudah ada pemahaman mengenai perlunya pengelolaan kemanan informasi akan tetapi penerapan langkah pengamanan masih belum teratur. Untuk mencapai tingkat kematangan V dan sesuai dengan Standar Nasional Indonesia (SNI PTI PDAM Tirta Moedal Kota Semarang dapat melakukan strategi perbaikan secara bertahap. Kata Kunci: Indeks Keamanan Informasi, SNI ISO/IEC 27001:2009, Evaluasi Keamanan Informasi, Tingkat Kelengkapan, Tingkat Kematangan

  10. Differential Processing of Low and High LET Radiation Induced DNA Damage: Investigation of Switch from ATM to ATR Signaling

    Science.gov (United States)

    Saha, Janapriya; Wang, Minli; Hada, Megumi; Cucinotta, Francis A.

    2011-01-01

    The members of the phosphatidylinositol kinase-like kinase family of proteins namely ataxia-telangiectasia mutated (ATM) and ATM- and Rad3-related (ATR) are directly responsible for the maintenance of genomic integrity by mounting DDR through signaling and facilitating the recruitment of repair factors at the sites of DNA damage along with coordinating the deployment of cell cycle checkpoints to permit repair by phosphorylating Checkpoint kinase Chk1, Chk2 and p53. High LET radiation from GCR (Galactic Cosmic Rays) consisting mainly of protons and high energy and charged (HZE) particles from SPE (Solar Particle Event) pose a major health risk for astronauts on their space flight missions. The determination of these risks and the design of potential safeguards require sound knowledge of the biological consequences of lesion induction and the capability of the cells to counter them. We here strive to determine the coordination of ATM and ATR kinases at the break sites directly affecting checkpoint signaling and DNA repair and whether differential processing of breaks induced by low and high LET radiation leads to possible augmentation of swap of these damage sensors at the sites of DNA damage. Exposure of cells to IR triggers rapid autophosphorylation of serine-1981 that causes dimer dissociation and initiates monomer formation of ATM. ATM kinase activity depends on the disruption of the dimer, which allows access and phosphorylation of downstream ATM substrates like Chk2. Evidence suggests that ATM is activated by the alterations in higher-order chromatin structure although direct binding of ATM to DSB ends may be a crucial step in its activation. On the other hand, in case of ATR, RPA (replication protein A)-coated ssDNA (single-stranded DNA) generated as a result of stalled DNA replication or during processing of chromosomal lesions is crucial for the localization of ATR to sites of DNA damage in association with ATR-interacting protein (ATRIP). Although the

  11. Quantitative Analysis of the Relative Transcript Levels of ABC Transporter Atr Genes in Aspergillus nidulans by Real-Time Reverse Transcription-PCR Assay

    OpenAIRE

    Pizeta Semighini, Camile; Marins, Mozart; Goldman, Maria Helena S.; Goldman, Gustavo Henrique

    2002-01-01

    The development of assays for quantitative analysis of the relative transcript levels of ABC transporter genes by real-time reverse transcription-PCR (RT-PCR) might provide important information about multidrug resistance in filamentous fungi. Here, we evaluate the potential of real-time RT-PCR to quantify the relative transcript levels of ABC transporter Atr genes from Aspergillus nidulans. The AtrA to AtrD genes showed different and higher levels in the presence of structurally unrelated dr...

  12. Variability and robustness of scatterers in HRR/ISAR ground target data and its influence on the ATR performance

    Science.gov (United States)

    Schumacher, R.; Schimpf, H.; Schiller, J.

    2011-06-01

    The most challenging problem of Automatic Target Recognition (ATR) is the extraction of robust and independent target features which describe the target unambiguously. These features have to be robust and invariant in different senses: in time, between aspect views (azimuth and elevation angle), between target motion (translation and rotation) and between different target variants. Especially for ground moving targets in military applications an irregular target motion is typical, so that a strong variation of the backscattered radar signal with azimuth and elevation angle makes the extraction of stable and robust features most difficult. For ATR based on High Range Resolution (HRR) profiles and / or Inverse Synthetic Aperture Radar (ISAR) images it is crucial that the reference dataset consists of stable and robust features, which, among others, will depend on the target aspect and depression angle amongst others. Here it is important to find an adequate data grid for an efficient data coverage in the reference dataset for ATR. In this paper the variability of the backscattered radar signals of target scattering centers is analyzed for different HRR profiles and ISAR images from measured turntable datasets of ground targets under controlled conditions. Especially the dependency of the features on the elevation angle is analyzed regarding to the ATR of large strip SAR data with a large range of depression angles by using available (I)SAR datasets as reference. In this work the robustness of these scattering centers is analyzed by extracting their amplitude, phase and position. Therefore turntable measurements under controlled conditions were performed targeting an artificial military reference object called STANDCAM. Measures referring to variability, similarity, robustness and separability regarding the scattering centers are defined. The dependency of the scattering behaviour with respect to azimuth and elevation variations is analyzed. Additionally generic types

  13. Status Report on the Fabrication of Fuel Cladding Chemical Interaction Test Articles for ATR Irradiations

    International Nuclear Information System (INIS)

    FeCrAl alloys are a promising new class of alloys for light water reactor (LWR) applications due to their superior oxidation and corrosion resistance in high temperature environments. The current R&D efforts have focused on the alloy composition and processing routes to generate nuclear grade FeCrAl alloys with optimized properties for enhanced accident tolerance while maintaining properties needed for normal operation conditions. Therefore, the composition and processing routes must be optimized to maintain the high temperature steam oxidation (typically achieved by increasing the Cr and Al content) while still exhibiting properties conducive to normal operation in a LWR (such as radiation tolerance where reducing Cr content is favorable). Within this balancing act is the addition of understanding the influence on composition and processing routes on the FeCrAl alloys for fuel-cladding chemical interactions (FCCI). Currently, limited knowledge exists on FCCI for the FeCrAl-UO2 clad-fuel system. To overcome the knowledge gaps on the FCCI for the FeCrAl-UO2 clad-fuel system a series of fueled irradiation tests have been developed for irradiation in the Advanced Test Reactor (ATR) housed at the Idaho National Laboratory (INL). The first series of tests has already been reported. These tests used miniaturized 17x17 PWR fuel geometry rodlets of second-generation FeCrAl alloys fueled with industrial Westinghouse UO2 fuel. These rodlets were encapsulated within a stainless steel housing.To provide high fidelity experiments and more robust testing, a new series of rodlets have been developed deemed the Accident Tolerant Fuel Experiment #1 Oak Ridge National Laboratory FCCI test (ATF-1 ORNL FCCI). The main driving factor, which is discussed in detail, was to provide a radiation environment where prototypical fuel-clad interface temperatures are met while still maintaining constant contact between industrial fuel and the candidate cladding alloys, hence promoting FCCI

  14. Status Report on the Fabrication of Fuel Cladding Chemical Interaction Test Articles for ATR Irradiations

    Energy Technology Data Exchange (ETDEWEB)

    Field, Kevin G. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Howard, Richard H. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2015-09-28

    FeCrAl alloys are a promising new class of alloys for light water reactor (LWR) applications due to their superior oxidation and corrosion resistance in high temperature environments. The current R&D efforts have focused on the alloy composition and processing routes to generate nuclear grade FeCrAl alloys with optimized properties for enhanced accident tolerance while maintaining properties needed for normal operation conditions. Therefore, the composition and processing routes must be optimized to maintain the high temperature steam oxidation (typically achieved by increasing the Cr and Al content) while still exhibiting properties conducive to normal operation in a LWR (such as radiation tolerance where reducing Cr content is favorable). Within this balancing act is the addition of understanding the influence on composition and processing routes on the FeCrAl alloys for fuel-cladding chemical interactions (FCCI). Currently, limited knowledge exists on FCCI for the FeCrAl-UO2 clad-fuel system. To overcome the knowledge gaps on the FCCI for the FeCrAl-UO2 clad-fuel system a series of fueled irradiation tests have been developed for irradiation in the Advanced Test Reactor (ATR) housed at the Idaho National Laboratory (INL). The first series of tests has already been reported. These tests used miniaturized 17x17 PWR fuel geometry rodlets of second-generation FeCrAl alloys fueled with industrial Westinghouse UO2 fuel. These rodlets were encapsulated within a stainless steel housing.To provide high fidelity experiments and more robust testing, a new series of rodlets have been developed deemed the Accident Tolerant Fuel Experiment #1 Oak Ridge National Laboratory FCCI test (ATF-1 ORNL FCCI). The main driving factor, which is discussed in detail, was to provide a radiation environment where prototypical fuel-clad interface temperatures are met while still maintaining constant contact between industrial fuel and the candidate cladding alloys

  15. Two-dimensional ATR-FTIR Spectroscopic Study on the Water Diffusion Behavior in Polyimide/Silica Nanocomposite

    Science.gov (United States)

    Shen, Yi; Wang, Hai-tao; Zhong, Wei; Wu, Pei-yi

    2006-12-01

    To consider the reliability and performance of electronic devices based on polyimide derivatives, dynamic water sorption and diffusion behavior in a polyimide derivative: poly(4'4-oxydiphenylene pyromellitimide) (PMDA-ODA)/silica nanocomposite was investigated by two-dimensional ATR-FTIR spectroscopy, by which three states of water molecules owning different H-bonding strength were distinguished. The amounts and strength of H-bonding also played a significant role in determining the diffusion rate of the different states of water molecules. The type of aggregated water molecules which also formed H-bonding with silicic acid (residues) or polyimide system was the last one diffusing to the polymer side in contact with the ATR crystal element because the polymeric matrix blocked their diffusion to a great extent. The diffusion coefficient was also estimated to gain the information of the dynamic diffusion behavior.

  16. The air membrane-ATR integrated gas turbine power cycle: A method for producing electricity with low CO2 emissions

    International Nuclear Information System (INIS)

    The air membrane-auto thermal reforming (AM-ATR) gas turbine cycle combines features of the R-ATR power cycle, introduced at the University of Florence, with ceramic, air separation membranes to achieve a novel combined cycle process with fuel decarbonisation and near-zero CO2 emissions. Within this process, the natural gas fuel is converted to H2 and CO through the auto thermal reforming process (ATR), i.e. combined partial oxidation and steam methane reforming, within the air separation membrane reactor. In a subsequent process unit, the H2 content of the reformed fuel is enriched by the well known CO-CO2 shift reaction. This fuel is then sent to an amine based carbon dioxide removal unit and, finally, to two combustors: the first one is located upstream of the membrane reformer (in order to achieve the required working temperature) and the second one is downstream of the membrane to reach the desired turbine inlet temperature (TIT). The main advantage of the proposed concept over other decarbonisation processes is the coupling of the membrane and the ATR reactor. This coupling greatly reduces the mass flow of syngas with respect to the air blown ATR contained in the previously proposed R-ATR, thus lowering the size of the syngas treatment section. Furthermore, as the oxygen production is integrated at high temperatures in the power cycle, the efficiency penalty of producing oxygen is much smaller than for the traditional cryogenic oxygen separation. The main advantages over other integrated GT-membrane concepts are the lower membrane operating temperature, lower levels of required air separation at high partial pressure driving forces (leading to lower membrane surface areas) and the possibility to achieve a higher TIT with top firing without increasing CO2 emissions. When compared to power plants with tail end CO2 separation, the CO2 removal process treats a gas at pressure and with a significantly higher CO2 concentration than that of gas turbine exhausts

  17. Electrooxidation of ethanol on Pt and PtRu surfaces investigated by ATR surface-enhanced infrared absorption spectroscopy

    Energy Technology Data Exchange (ETDEWEB)

    Silva, Marcio F.; Camara, Giuseppe A., E-mail: giuseppe.silva@ufms.br [Departamento de Quimica, Universidade Federal do Mato Grosso do Sul, Campo Grande-MS (Brazil); Batista, Bruno C.; Boscheto, Emerson [Instituto de Quimica de Sao Carlos, Universidade de Sao Paulo, Sao Carlos-SP, (Brazil); Varela, Hamilton, E-mail: varela@iqsc.usp.br [Ertl Center for Electrochemistry and Catalysis, Gwangju Institute of Science and Technology (GIST), Gwangju (Korea, Republic of)

    2012-05-15

    Herein, it was investigated for the first time the electro-oxidation of ethanol on Pt and PtRu electrodeposits in acidic media by using in situ surface enhanced infrared absorption spectroscopy with attenuated total reflection (ATR-SEIRAS). The experimental setup circumvents the weak absorbance signals related to adsorbed species, usually observed for rough, electrodeposited surfaces, and allows a full description of the CO coverage with the potential for both catalysts. The dynamics of adsorption-oxidation of CO was accessed by ATR-SEIRAS experiments (involving four ethanol concentrations) and correlated with expressions derived from a simple kinetic model. Kinetic analysis suggests that the growing of the CO adsorbed layer is nor influenced by the presence of Ru neither by the concentration of ethanol. The results suggest that the C-C scission is not related to the presence of Ru and probably happens at Pt sites. (author)

  18. ATR-FT-IR spectroscopy in the region of 500-230 cm -1 for identification of inorganic red pigments

    Science.gov (United States)

    Vahur, Signe; Knuutinen, Ulla; Leito, Ivo

    2009-08-01

    It is demonstrated that micro-ATR-FT-IR in the low wave number range (500-230 cm -1) can be well used for identification of pigments in paint samples thereby markedly extending the possibilities of pigment identification by ATR-IR spectroscopy into the realm of pigments having no absorptions in the mid-IR region. Reference spectra of pigments can be conveniently obtained by mixing them with linseed oil in approximately 1:1 mass ratio. Vermilion (or cinnabar), read lead, different red iron oxide pigments and cadmium red can be identified. In some cases the method can be used alone for pigment identification and in many cases it provides useful additional evidence for pigment identification using other instrumental techniques (electron microprobe analysis, XRF, optical microscopy).

  19. RHINO forms a stoichiometric complex with the 9-1-1 checkpoint clamp and mediates ATR-Chk1 signaling

    OpenAIRE

    Lindsey-Boltz, Laura A.; Kemp, Michael G.; Capp, Christopher; Sancar, Aziz

    2015-01-01

    The ATR-Chk1 signaling pathway mediates cellular responses to DNA damage and replication stress and is composed of a number of core factors that are conserved throughout eukaryotic organisms. However, humans and other higher eukaryotic species possess additional factors that are implicated in the regulation of this signaling network but that have not been extensively studied. Here we show that RHINO (for Rad9, Rad1, Hus1 interacting nuclear orphan) forms complexes with both the 9-1-1 checkpoi...

  20. Determination of drug content in semisolid formulations by non-invasive spectroscopic methods: FTIR - ATR, - PAS, - Raman and PDS

    Energy Technology Data Exchange (ETDEWEB)

    Gotter, B; Hein, J; Neubert, R H H [Institute of Pharmacy, Martin-Luther-University, Wolfgang-Langenbeck-Str. 4, 06120 Halle/Saale (Germany); Faubel, W; Heissler, St, E-mail: bernhard.gotter@pharmazie.uni-halle.d [Institute of Functional Interfaces, Karlsruhe Institute of Technology, Herrmann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen (Germany)

    2010-03-01

    This study elucidates the potential use of photothermal deflection spectroscopy (PDS), FTIR photoacoustic (FTIR-PAS), FT Raman, and FTIR-attenuated total reflection (FTIR-ATR) spectroscopy as analytical tools for investigating the drug content in semisolid formulations. Regarding the analytical parameters, this study demonstrates the photothermal beam deflection to be definitely comparable to well established spectroscopic methods for this purpose. The correlation coefficients range from 0.990 to 0.999. Likewise, repeatability and limit of detection are comparable.

  1. ATR-FTIR spectroscopic characterization of coexisting carbonate surface complexes on hematite

    Science.gov (United States)

    Bargar, J.R.; Kubicki, J.D.; Reitmeyer, R.; Davis, J.A.

    2005-01-01

    The speciation of carbonate adsorbed to hematite in air-equilibrated aqueous solutions has been studied using ATR-FTIR spectroscopy. Samples were measured over a range of pH conditions, at 0.1 M NaCl and at low ionic strength, and in H2O and D2O solutions to permit a multispecies analysis of the data. Second-derivative analyses and fits to the spectra indicate the presence of two major and two minor surface-bound carbonate species. The two major complexes coexist at near-neutral pH and low ionic strength. One of these two complexes is relatively sensitive to ionic strength, being displaced at 0.1 M NaCl, whereas the other is not. Comparison of experimental to DFT/MO-calculated frequencies suggest these two major species to be (a) a monodentate binuclear inner-sphere carbonate surface complex, and (b) a fully or partially solvated carbonate (CO32-) species that is symmetry broken and appears to reside in the structured vicinal water layers at the hematite-water interface, retained by hydrogen bonding and/or other forces. Minor carbonate complexes include diffuse layer CO32- and an unidentified inner-sphere species. Both of the dominant species observed here are likely to be significant controls of the surface charge and sorptive properties of Fe-oxides. Copyright ?? 2005 Elsevier Ltd.

  2. Analysis code for medium and small rupture accidents in ATR. LOTRAC/HEATUP

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-08-01

    In the evaluation of thermo-hydraulic and fuel temperature transient changes in the events which are classified in medium and small rupture accidents of reactor coolant loss that is the safety evaluation event of the ATR, the analysis code for synthetic thermo-hydraulic transient change at the time of medium and small ruptures LOTRAC and the detailed analysis code for fuel temperature HEATUP are used, respectively. By using the LOTAC, the thermo-hydraulic behavior of reactor cooling facility and the temperature behavior of fuel at the time of blow-down are analyzed, and also the characteristics of changing reactor thermal output is analyzed, considering the functioning characteristics of emergency core cooling system. Based on the data of thermo-hydraulic behavior obtained by the LOTRAC, the time of beginning the turn-around of fuel cladding tube temperature obtained by the data of ECCS pouring characteristics, the heat transfer rate after the turn-around and so on, the detailed temperature change of fuel elements is analyzed by the HEATUP, and the highest temperature and the amount of oxidation of fuel cladding tubes are determined. The LOTRAC code, the HEATUP code, various analysis models, and rupture simulation experiment are reported. (K.I.)

  3. Advanced Test Reactor National Scientific User Facility (ATR NSUF) Monthly Report October 2014

    Energy Technology Data Exchange (ETDEWEB)

    Dan Ogden

    2014-10-01

    Advanced Test Reactor National Scientific User Facility (ATR NSUF) Monthly Report October 2014 Highlights • Rory Kennedy, Dan Ogden and Brenden Heidrich traveled to Germantown October 6-7, for a review of the Infrastructure Management mission with Shane Johnson, Mike Worley, Bradley Williams and Alison Hahn from NE-4 and Mary McCune from NE-3. Heidrich briefed the group on the project progress from July to October 2014 as well as the planned path forward for FY15. • Jim Cole gave two invited university seminars at Ohio State University and University of Florida, providing an overview of NSUF including available capabilities and the process for accessing facilities through the peer reviewed proposal process. • Jim Cole and Rory Kennedy co-chaired the NuMat meeting with Todd Allen. The meeting, sponsored by Elsevier publishing, was held in Clearwater, Florida, and is considered one of the premier nuclear fuels and materials conferences. Over 340 delegates attended with 160 oral and over 200 posters presented over 4 days. • Thirty-one pre-applications were submitted for NSUF access through the NE-4 Combined Innovative Nuclear Research Funding Opportunity Announcement. • Fourteen proposals were received for the NSUF Rapid Turnaround Experiment Summer 2014 call. Proposal evaluations are underway. • John Jackson and Rory Kennedy attended the Nuclear Fuels Industry Research meeting. Jackson presented an overview of ongoing NSUF industry research.

  4. The degradation potential of PET bottles in the marine environment: An ATR-FTIR based approach

    Science.gov (United States)

    Ioakeimidis, C.; Fotopoulou, K. N.; Karapanagioti, H. K.; Geraga, M.; Zeri, C.; Papathanassiou, E.; Galgani, F.; Papatheodorou, G.

    2016-03-01

    The dominance and persistence of plastic debris in the marine environment are well documented. No information exists in respect to their lifespan in the marine environment. Nevertheless, the degradation potential of plastic litter items remains a critical issue for marine litter research. In the present study, polyethylene terephthalate bottles (PETs) collected from the submarine environment were characterized using ATR-FTIR in respect to their degradation potential attributed to environmental conditions. A temporal indication was used as indicative to the years of presence of the PETs in the environment as debris. PETs seem to remain robust for approximately fifteen years. Afterwards, a significant decrease of the native functional groups was recorded; some even disappear; or new-not typical for PETs-are created. At a later stage, using the PET time series collected from the Saronikos Gulf (Aegean Sea–E. Mediterranean), it was possible to date bottles that were collected from the bottom of the Ionian Sea (W. Greece). It is the first time that such a study has been conducted with samples that were actually degraded in the marine environment.

  5. Radiation damage studies of membrane model systems by means of ATR-IR spectroscopy

    International Nuclear Information System (INIS)

    An investigation was made of the destruction of thin oriental layer systems by means of IR spectroscopy in an ATR (Attenuated Total Reflection) mode. 8 tripalmitin layers were deposited with transfer ratios between 0.95-1, 1 on always 2 Ge internal reflection plates, previously coated with a Cd-arachidate monolayer. Both Ge-plates were then mounted on a holder fitting like a photographic plate into a special device normally used for step-wedge exposures in the e.m. image plane. Through a fitting mask one of the plates was exposed on each side to 100 keV electrons. The IR spectrum of reference plate (not irradiated) showed no defects at all. In comparison a plate irradiated with effectively 5 x 10-4 Cb/cm2 at a measured current density of 1,24.10-8 A/cm2 shows serious defects in the tripalmitin layers, although this dose is far below what is considered necessary for a single heavy atom detection. (author)

  6. Development of ATR type steam separator performance analysis code and its validation, (1)

    International Nuclear Information System (INIS)

    The purpose of the study is to develop a method for predicting steam carryunder which is one of the important characteristics of a steam separator. Bubbles returning to the liquid surface and trapped by the re-circulating flow are calculated by tracking the behavior of bubbles moving in liquid bulk where velocity and temperature distributions have been calculated before-hand in conjunction with the Monte-Carlo method. Regarding the statistics of bubbles, a survey of references and visual tests have been conducted. To validate this method, several tests to measure bubble behavior under air/water conditions at atmospheric pressure and high temperature and pressure ranging 3 ∼ 7 MPa have been conducted with a full-scale steam separator. As a result, the developed method predicted with good precision the carryunder ratio obtained by the full-scale tests under the condition that carried-under void fraction was less than 20 %, but underestimated carryunder ratio in the ATR 'Fugen' reactor in which steam drum water level was shallow and average void fraction in water bulk was high. This method has a characteristic that carryunder ratio is underestimated in the case that void fraction is more than 20 %. (author)

  7. The Conference Proceedings of the 2003 Air Transport Research Society (ATRS) World Conference, Volume 5

    Science.gov (United States)

    Bowen, Brent (Editor); Gudmundsson, Sveinn (Editor); Oum, Tae (Editor)

    2003-01-01

    The UNO Aviation Institute Monograph Series began in 1994 as a key component of the education outreach and information transfer missions of the Aviation Institute and the NASA Nebraska Space Grant & EPSCoR Programs. The series is an outlet for aviation materials to be indexed and disseminated through an efficient medium. Publications are welcome in all aspects of aviation. Publication formats may include, but are not limited to, conference proceedings, bibliographies, research reports, manuals, technical reports, and other documents that should be archived and indexed for future reference by the aviation and world wide communities. The Conference proceedings of the 2003 Air Transport Research Society (ATRS) world conference, volume 5 is presented. The topics include: 1) The Temporal Configuration of Airline Networks in Europe; 2) Determination and Applications of Environmental Costs at Different Sized Airports-Aircraft Noise and Engine Emissions; 3) Cost Effective Measures to Reduce CO2 Emissions in the Air Freight Sector; 4) An Assessment of the Sustainability of Air Transport System: Quantification of Indicators; 5) Regulation, Competition and Network Evolution in Aviation; 6) Regulation in the Air: Price and Frequency Cap; 7) Industry Consolidation and Future Airline Network Structures in Europe; 8) Application of Core Theory to the U.S. Airline Industry; 9) Air Freight Transshipment Route Choice Analysis; 10) A Fuzzy Approach of the Competition on Air Transport Market; and 11) Developing Passenger Demand Models for International Aviation from/to Egypt: A Case Study of Cairo Airport and Egyptair.

  8. The ATM and ATR inhibitors CGK733 and caffeine suppress cyclin D1 levels and inhibit cell proliferation

    International Nuclear Information System (INIS)

    The ataxia telangiectasia mutated (ATM) and the ATM- related (ATR) kinases play a central role in facilitating the resistance of cancer cells to genotoxic treatment regimens. The components of the ATM and ATR regulated signaling pathways thus provide attractive pharmacological targets, since their inhibition enhances cellular sensitivity to chemo- and radiotherapy. Caffeine as well as more specific inhibitors of ATM (KU55933) or ATM and ATR (CGK733) have recently been shown to induce cell death in drug-induced senescent tumor cells. Addition of these agents to cancer cells previously rendered senescent by exposure to genotoxins suppressed the ATM mediated p21 expression required for the survival of these cells. The precise molecular pharmacology of these agents however, is not well characterized. Herein, we report that caffeine, CGK733, and to a lesser extent KU55933, inhibit the proliferation of otherwise untreated human cancer and non-transformed mouse fibroblast cell lines. Exposure of human cancer cell lines to caffeine and CGK733 was associated with a rapid decline in cyclin D1 protein levels and a reduction in the levels of both phosphorylated and total retinoblastoma protein (RB). Our studies suggest that observations based on the effects of these compounds on cell proliferation and survival must be interpreted with caution. The differential effects of caffeine/CGK733 and KU55933 on cyclin D1 protein levels suggest that these agents will exhibit dissimilar molecular pharmacological profiles

  9. ATR-SEIRAS study of CO adsorption and oxidation on Rh modified Au(111-25 nm) film electrodes in 0.1 M H2SO4

    OpenAIRE

    Xu, Qinqin; Berná Galiano, Antonio; Pobelov, Ilya V.; Rodes García, Antonio; Feliu, Juan M.; Wandlowski, Thomas; Kuzume, Akiyoshi

    2015-01-01

    Rh modified Au(111-25 nm) electrodes, prepared by electron beam evaporation and galvanostatic deposition, were employed to study adsorption and electro-oxidation of CO on Rh in 0.1 M sulfuric acid solution by in situ attenuated total reflection surface enhanced infrared absorption spectroscopy (ATR-SEIRAS). The results of ATR-SEIRAS experiments were compared with those obtained by infrared reflection absorption spectroscopy on three low-index Rh single crystal surfaces. The Rh film deposited ...

  10. Ataxia telangiectasia mutated and Rad3 related (ATR protein kinase inhibition is synthetically lethal in XRCC1 deficient ovarian cancer cells.

    Directory of Open Access Journals (Sweden)

    Rebeka Sultana

    Full Text Available INTRODUCTION: Ataxia telangiectasia mutated and Rad3 Related (ATR protein kinase is a key sensor of single-stranded DNA associated with stalled replication forks and repair intermediates generated during DNA repair. XRCC1 is a critical enzyme in single strand break repair and base excision repair. XRCC1-LIG3 complex is also an important contributor to the ligation step of the nucleotide excision repair response. METHODS: In the current study, we investigated synthetic lethality in XRCC1 deficient and XRCC1 proficient Chinese Hamster ovary (CHO and human ovarian cancer cells using ATR inhibitors (NU6027. In addition, we also investigated the ability of ATR inhibitors to potentiate cisplatin cytotoxicity in XRCC1 deficient and XRCC1 proficient CHO and human cancer cells. Clonogenic assays, alkaline COMET assays, γH2AX immunocytochemistry, FACS for cell cycle as well as FITC-annexin V flow cytometric analysis were performed. RESULTS: ATR inhibition is synthetically lethal in XRCC1 deficient cells as evidenced by increased cytotoxicity, accumulation of double strand DNA breaks, G2/M cell cycle arrest and increased apoptosis. Compared to cisplatin alone, combination of cisplatin and ATR inhibitor results in enhanced cytotoxicity in XRCC1 deficient cells compared to XRCC1 proficient cells. CONCLUSIONS: Our data provides evidence that ATR inhibition is suitable for synthetic lethality application and cisplatin chemopotentiation in XRCC1 deficient ovarian cancer cells.

  11. Image-based ATR utilizing adaptive clutter filter detection, LLRT classification, and Volterra fusion with application to side-looking sonar

    Science.gov (United States)

    Aridgides, Tom; Fernández, Manuel

    2010-04-01

    An improved automatic target recognition (ATR) processing string has been developed. The overall processing string consists of pre-processing, subimage adaptive clutter filtering, detection, feature extraction, optimal subset feature selection, feature orthogonalization and classification processing blocks. The objects that are classified by three distinct ATR strings are fused using the classification confidence values and their expansions as features, and using "summing" or log-likelihood-ratio-test (LLRT) based fusion rules. These three ATR processing strings were individually developed and tuned by researchers from different companies. The utility of the overall processing strings and their fusion was demonstrated with an extensive side-looking sonar dataset. In this paper we describe a new processing improvement: six additional classification features are extracted, using primarily target shadow information and a feature extraction window whose length is now made variable as a function of range. This new ATR processing improvement resulted in a 3:1 reduction in false alarms. Two advanced fusion algorithms are subsequently applied: First, a nonlinear Volterra expansion (2nd order) feature-LLRT fusion algorithm is employed. Second, a repeated application of a subset Volterra feature selection / feature orthogonalization / LLRT fusion block is utilized. It is shown that cascaded Volterra feature- LLRT fusion of the ATR processing strings outperforms baseline "summing" and single-stage Volterra feature-LLRT fusion algorithms, yielding significant improvements over the best single ATR processing string results, and providing the capability to correctly call the majority of targets while maintaining a very low false alarm rate.

  12. An Approach for Routine Analytical Detection of Beeswax Adulteration Using FTIR-ATR Spectroscopy

    Directory of Open Access Journals (Sweden)

    Svečnjak Lidija

    2015-12-01

    Full Text Available Although beeswax adulteration represents one of the main beeswax quality issues, there are still no internationally standardised analytical methods for routine quality control. The objective of this study was to establish an analytical procedure suitable for routine detection of beeswax adulteration using FTIR-ATR spectroscopy. For the purpose of this study, reference IR spectra of virgin beeswax, paraffin, and their mixtures containing different proportions of paraffin (5 - 95%, were obtained. Mixtures were used for the establishment of calibration curves. To determine the prediction strength of IR spectral data for the share of paraffin in mixtures, the Partial Least Squares Regression method was used. The same procedure was conducted on beeswax-beef tallow mixtures. The model was validated using comb foundation samples of an unknown chemical background which had been collected from the international market (n = 56. Selected physico-chemical parameters were determined for comparison purposes. Results revealed a strong predictive power (R2 = 0.999 of IR spectra for the paraffin and beef tallow share in beeswax. The results also revealed that the majority of the analysed samples (89% were adulterated with paraffin; only 6 out of 56 (11% samples were identified as virgin beeswax, 28% of the samples exhibited a higher level of paraffin adulteration (>46% of paraffin, while the majority of the analysed samples (50% were found to be adulterated with 5 - 20% of paraffin. These results indicate an urgent need for routine beeswax authenticity control. In this study, we demonstrated that the analytical approach defining the standard curves for particular adulteration levels in beeswax, based on chemometric modelling of specific IR spectral region indicative for adulteration, enables reliable determination of the adulterant proportions in beeswax.

  13. ATR-FTIR characterization of transport properties of benzoic acid ion-pairs in silicone membranes.

    Science.gov (United States)

    Tantishaiyakul, Vimon; Phadoongsombut, Narubodee; Wongpuwarak, Wibul; Thungtiwachgul, Jatupit; Faroongsarng, Damrongsak; Wiwattanawongsa, Kamonthip; Rojanasakul, Yon

    2004-09-28

    A novel technique based on Attenuated Total Reflectance Fourier Transform Infrared (ATR-FTIR) spectroscopy was used to study the transport of benzoic acid ion-pairs/salts in silicone membranes. The benzoic acid ion-pairs were prepared using various counter-ions with different degrees of lipophilicity, e.g. triethylamine (TA), diethylamine (DE), tert-butylamine (t-BA), 2-amino-2-methyl-propanol (AMP), and 2-amino-2-methyl-propanediol (AMPD). Silicone membrane, treated or untreated with propylene glycol (PG), was placed on the surface of a ZnSe crystal and the transport solution was applied to the upper surface of the membrane. A mathematical model, based on Fick's second law describing the build up of permeant concentration at the membrane/crystal interface with time was applied to determine diffusion coefficients. Absorption due to the acid (1700 cm(-1)) or benzoate anion (1555 cm(-1)) was observed at different regions without the interference from PG or silicone membrane. Benzoate anion, a charged species, was observed to permeate the membrane. The permeation of benzoate anion from sodium benzoate and polar ion-pairs of AMP and AMPD was very low in contrast to their high-saturated concentrations in PG as compared to the t-BA ion-pair. This indicated that benzoate anion preferentially permeates the membrane as an ion-pair rather than a single anion; otherwise its permeation should correspond to its concentration in PG instead of the lipophilicity of the ion-pairs. Additionally, the diffusion coefficient values of benzoic acid and benzoate anions through the treated and untreated membranes were not statistically different. PMID:15363507

  14. ATR-FTIR investigations of secondary structure of lyophilized proteins in water and deuterated water

    International Nuclear Information System (INIS)

    The conformational and structural changes due to lyophilization of bovine hemoglobin, casein and trypsin of neutral pH value have been studied by FT-IR spectrometry using an Attenuated Total Reflectance (ATR) accessory (Bruker EQUINOX 55 spectrometer). Lyophilization induced significant structural alterations in proteins, characterized by a decrease in the α-helix and a significant increase in the β-sheet content. The proteins were lyophilized from twice-distilled water solution and deuterated water solution. The secondary structure was quantitatively determined using the second derivative of the protein spectra and curve fitting procedures to resolve the overlapping components under the amide I contour. The band of amide I, is due to the in-plane C=O stretching vibration, weakly coupled with C-N stretching and in-plane N-H bending. Each type of secondary structure (i.e. α-helix, β-sheet, β-turn and disordered) gives rise to different C-O stretching frequencies, hence, results in characteristic band positions which are designated by wavenumber (cm-1). In the Fourier domain derivative, the second-derivative analysis of infrared spectra allows direct quantitative analysis of the secondary structural components of proteins. Thus, the areas corresponding to the different types of secondary structure are quantitatively and qualitatively evaluated by integration and curve fitting. The second derivatives of all spectra were calculated using the spectrometer software OPUS. Before starting the fitting procedure, the obtained depths of the minima in the second derivative spectrum and, subsequently, the calculated maximum intensities were corrected for the interference of all neighboring peaks. The curve fitting is performed by stepwise iterative adjustment towards a minimum root-mean-square error of the different parameters determining the shape and position of the absorption peaks. (author)

  15. Coolant void reactivity behaviour in pressure tube type plutonium fuel lattices of ATR

    International Nuclear Information System (INIS)

    It is essential to the reactor physical field in respect of the thermal neutron reactor specially utilizing plutonium to consistently clarify the effect of the resonance in the around 0.3eV for plutonium239 and the effect of the various fuel compositions and fuel material concentrations on the void reactivity in the ATR lattice. For this purpose, using the improved WIMS code to be able to calculate the detailed thermal neutron spectrum containing the resonance in 0.3eV for plutonium239 and various components due to the reactivity relevant to the void reactivity, the void reactivity in the HWR lattice has been analyzed in detail. For the purpose of improving the accuracy of the calculated void reactivity, the nuclear data for the WIMS code has been replaced with the JENDL-3.1 library. As the results of the analysis, for the identical macro thermal neutron absorption cross section for fuel, the void reactivity is reduced to the negative side more for the MOX with high content of plutonium239 in plutonium than in uranium. The reduction of the void reactivity to the negative side by plutonium239 is due to the presence of the resonance in 0.3eV for plutonium239. That is because the higher the content of plutonium239 is, the less the recovery effect for neutron density within the resonance energy in 0.3eV is with increase in coolant void fraction, so that the decreased resonance nuclear fission rate for plutonium239 contributes to the negative side for the void reactivity. This effect is more remarkable for the larger pitch lattice with softer thermal neutron spectrum. (author)

  16. UV-induced nuclear import of XPA is mediated by importin-α4 in an ATR-dependent manner.

    Directory of Open Access Journals (Sweden)

    Zhengke Li

    Full Text Available Xeroderma pigmentosum Group A (XPA is a crucial factor in mammalian nucleotide excision repair (NER and nuclear import of XPA from the cytoplasm for NER is regulated in cellular DNA damage responses in S-phase. In this study, experiments were carried out to determine the transport mechanisms that are responsible for the UV (ultraviolet-induced nuclear import of XPA. We found that, in addition to the nuclear localization signal (NLS of XPA, importin-α4 or/and importin-α7 are required for the XPA nuclear import. Further investigation indicated that, importin-α4 and importin-α7 directly interacted with XPA in cells. Interestingly, the binding of importin-α4 to XPA was dependent on UV-irradiation, while the binding of importin-α7 was not, suggesting a role for importin-α7 in nuclear translocation of XPA in the absence of DNA damage, perhaps with specificity to certain non-S-phases of the cell-cycle. Consistent with the previous report of a dependence of UV-induced XPA nuclear import on ataxia telangiectasia and Rad3-related protein (ATR in S-phase, knockdown of ATR reduced the amount of XPA interacting with importin-α4. In contrast, the GTPase XPA binding protein 1 (XAB1, previously proposed to be required for XPA nuclear import, showed no effect on the nuclear import of XPA in our siRNA knockdown analysis. In conclusion, our results suggest that upon DNA damage transport adaptor importin-α4 imports XPA into the nucleus in an ATR-dependent manner, while XAB1 has no role in this process. In addition, these findings reveal a potential new therapeutic target for the sensitization of cancer cells to chemotherapy.

  17. In situ-ATR-FTIR analysis on the uptake and release of streptomycin from polyelectrolyte complex layers

    Science.gov (United States)

    Torger, B.; Müller, M.

    2013-03-01

    In-situ ATR-FTIR spectroscopy and line shape analysis of the diagnostic spectral region was used to quantify the bound amount and release of the antibiotic streptomycin (STRP) at polyelectrolyte (PEL) multilayers (PEM) of poly(ethyleneimine) (PEI) and poly(acrylic acid) (PAA) or PEI and sodium alginate (ALG). Unlike common concepts based on the drug enrichment of the release medium, this analytical concept allowed to measure quantitatively the drug depletion in the delivery matrix. The measured kinetic in situ ATR-FTIR data were analysed by a modified Korsmeyer-Peppas equation based on two characteristic release parameters k and n. As main experimental parameters the number of PEL layers (adsorption steps) z and the STRP/PEL ratio were varied. For z = 8 the STRP/PEL ratio showed the most significant influence on release kinetics, whereby for STRP/PEL = 1:25 slowest (n = 0.77) and lowest (k = 21.4%) and for STRP/PEL = 1:5 most rapid (n = 0.30) and highest (k = 58.6%) drug releases were found. PEM-PEI/ALG-8 (STRP/PEL = 1:5) revealed slower release rates (n = 0.58) and lower released STRP amounts (k = 17.1%) compared to PEI/PAA. UV-VIS data on time dependent STRP enrichment of the release medium showed a similar trend compared to respective ATR-FTIR data on STRP depletion in PEM. Released amounts of around 1-2 mg from the herein introduced PEM films could be determined. The introduced analytical concept will be used as screening tool for other drugs, drug eluting films and bone substituting materials.

  18. Gastritis crónica atrófica: mecanismos patogénicos por hipersensibilidad celular

    Directory of Open Access Journals (Sweden)

    Rosemary Recavarren Asencios

    2002-07-01

    Full Text Available La Gastritis Crónica Atrófica, de alta incidencia en la infección por Helicobacter pylori, no ha tenido hasta hoy mecanismos patogénicos establecidos. La Gastritis por Helicobacter pylori, claramente relacionada a la Gastritis Crónica Activa Superficial, no ha encontrado mecanismos que la conecten con la Gastritis Crónica Atrófica. Hasta hace poco, eran consideradas por algunos autores como lesiones independientes. En el presente trabajo, se estudiaron 42 biopsias gástricas antrales o corporales, con Gastritis Crónica Atrófica en diferentes estadíos. Las lesiones histológicas que comprenden a esta última, van desde la "infiltración linfoide profunda" en las glándulas gástricas propias, hasta el reemplazo de las mismas por tejido fibroinflamatorio. Por métodos inmunohistoquímicos, hemos podido comprobar que las células linfoides que infiltran el estrato glandular propio del estómago están conformadas por linfocitos T CD8+ (citotóxicos y por células linfocíticas B secretoras de anticuerpos. Planteamos en el presente trabajo que, los linfocitos T citotóxicos agredirían a las glándulas propias antrales y corporales destruyéndolas y produciendo de esta forma su reemplazo por tejido fibroinflamatorio. Similares acciones se producirían por linfocitos B, pero a través de la secreción de anticuerpos locales contra células epiteliales glandulares gástricas.

  19. PEMETAAN WILAYAH RAWAN BENCANA BERDASARKAN DATA IKROSEISMIK MENGGUNAKAN TDS ( Time Digital Seismograph Tipe 303 S ( Studi Kasus : Kampus I UIN Maulana Malik Ibrahim Malang dan Sekitarnya

    Directory of Open Access Journals (Sweden)

    Irjan, Ahmad Bukhori

    2012-03-01

    Full Text Available Telah dilakukan penelitian tentang mikrozonasi seismik di kampus I UIN Maulana  Malik Ibrahim  Malang  dan  sekitarnya.  penelitian  yang  dilakukan  oleh  penulis  adalah  penelitian  awal mikrozonasi  di  wilayah  kampus  I  UIN  Maulana  Malik  Ibrahim  Malang  dan  sekitarnya  untuk mengatahui  spektral  rasio  H/V(horizontal  vertikal  sehingga  dapat  diketahui  tingkat  kerawanan kerusakan  akibat   gempabumi   yang   dapat   digunakan   dalam  mitigasi   bencana   alam,   terutama gempabumi.  Mikrotremor  merupakan  vibrasi  lemah  di  permukaan  bumi  yang  berlangsung  terus menerus akibat adanya sumber getar seperti aktivitas manusia, industri dan lalu lintas. Sumber-sumber lain seperti interaksi angin, bangunan, arus laut dan gelombang laut periode panjang juga merupakan sumber  mikrotremor.  Penelitian  ini  dilakukan  dengan  menggunakan  metode  HVSR  (Horizontal Vertical Spectral Ratio atau A dengan merekam ambient noise atau getaran alami yang timbul dari alam di kampus I UIN Maulana Malik Ibrahim Malang dan sekitarnya akibat  gempabumi. Hal ini akan berguna untuk melihat karakteristik lapisan sedimen seperti frekuensi dominan (   sehingga efek geologi dan topograpi dapat dikurangi ketika bencana terjadi. Berdasarkan hasil  yang diperoleh dari penelitian, antara    dan A memperlihatkan bahwa potensi kerusakan akibat gempabumi adalah cukup rendah. Hal ini bersesuaian dengan nilai indeks kerentanan seismik (Kg yang berkisar antara 0,055 hingga 2,856. Dari analisis ketiga parameter ditemukan potensi yang tinggi di sekitar wilayah titik 5 dan 4 yang memiliki nilai indeks kerentanan seismik (Kg sebesar 31,205 dan 76,097.

  20. Mutation analysis and characterization of ATR sequence variants in breast cancer cases from high-risk French Canadian breast/ovarian cancer families

    International Nuclear Information System (INIS)

    Ataxia telangiectasia-mutated and Rad3-related (ATR) is a member of the PIK-related family which plays, along with ATM, a central role in cell-cycle regulation. ATR has been shown to phosphorylate several tumor suppressors like BRCA1, CHEK1 and TP53. ATR appears as a good candidate breast cancer susceptibility gene and the current study was designed to screen for ATR germline mutations potentially involved in breast cancer predisposition. ATR direct sequencing was performed using a fluorescent method while widely available programs were used for linkage disequilibrium (LD), haplotype analyses, and tagging SNP (tSNP) identification. Expression analyses were carried out using real-time PCR. The complete sequence of all exons and flanking intronic sequences were analyzed in DNA samples from 54 individuals affected with breast cancer from non-BRCA1/2 high-risk French Canadian breast/ovarian families. Although no germline mutation has been identified in the coding region, we identified 41 sequence variants, including 16 coding variants, 3 of which are not reported in public databases. SNP haplotypes were established and tSNPs were identified in 73 healthy unrelated French Canadians, providing a valuable tool for further association studies involving the ATR gene, using large cohorts. Our analyses led to the identification of two novel alternative splice transcripts. In contrast to the transcript generated by an alternative splicing site in the intron 41, the one resulting from a deletion of 121 nucleotides in exon 33 is widely expressed, at significant but relatively low levels, in both normal and tumoral cells including normal breast and ovarian tissue. Although no deleterious mutations were identified in the ATR gene, the current study provides an haplotype analysis of the ATR gene polymorphisms, which allowed the identification of a set of SNPs that could be used as tSNPs for large-scale association studies. In addition, our study led to the characterization of a

  1. Mutation analysis and characterization of ATR sequence variants in breast cancer cases from high-risk French Canadian breast/ovarian cancer families

    Directory of Open Access Journals (Sweden)

    Pichette Roxane

    2006-09-01

    Full Text Available Abstract Background Ataxia telangiectasia-mutated and Rad3-related (ATR is a member of the PIK-related family which plays, along with ATM, a central role in cell-cycle regulation. ATR has been shown to phosphorylate several tumor suppressors like BRCA1, CHEK1 and TP53. ATR appears as a good candidate breast cancer susceptibility gene and the current study was designed to screen for ATR germline mutations potentially involved in breast cancer predisposition. Methods ATR direct sequencing was performed using a fluorescent method while widely available programs were used for linkage disequilibrium (LD, haplotype analyses, and tagging SNP (tSNP identification. Expression analyses were carried out using real-time PCR. Results The complete sequence of all exons and flanking intronic sequences were analyzed in DNA samples from 54 individuals affected with breast cancer from non-BRCA1/2 high-risk French Canadian breast/ovarian families. Although no germline mutation has been identified in the coding region, we identified 41 sequence variants, including 16 coding variants, 3 of which are not reported in public databases. SNP haplotypes were established and tSNPs were identified in 73 healthy unrelated French Canadians, providing a valuable tool for further association studies involving the ATR gene, using large cohorts. Our analyses led to the identification of two novel alternative splice transcripts. In contrast to the transcript generated by an alternative splicing site in the intron 41, the one resulting from a deletion of 121 nucleotides in exon 33 is widely expressed, at significant but relatively low levels, in both normal and tumoral cells including normal breast and ovarian tissue. Conclusion Although no deleterious mutations were identified in the ATR gene, the current study provides an haplotype analysis of the ATR gene polymorphisms, which allowed the identification of a set of SNPs that could be used as tSNPs for large-scale association

  2. Microstructural examination of V-(3-6%)Cr-(3-5%)Ti irradiated in the ATR-A1 experiment

    Energy Technology Data Exchange (ETDEWEB)

    Gelles, D.S. [Pacific Northwest National Lab., Richland, WA (United States)

    1998-09-01

    Microstructural examination results are reported for four heats of V-(3-6%)Cr-(3-5%)Ti irradiated in the ATR-A1 experiment to {approximately}4 dpa at {approximately}200 and 300 C to provide an understanding of the microstructural evolution that may be associated with degradation of mechanical properties. Fine precipitates were observed in high density intermixed with small defect clusters for all conditions examined following the irradiation. The irradiation-induced precipitation does not appear to be affected by preirradiation heat treatment or composition.

  3. SB-ATR FTIR Spectroscopic Monitoring of Free Fatty Acids in Commercially Available Nigella sativa (Kalonji) Oil

    OpenAIRE

    2014-01-01

    Free fatty acids (FFA) in Nigella sativa (N. sativa) commercial and seed oil were determined using single-bounce attenuated total reflectance (SB-ATR) Fourier transform infrared (FTIR) spectroscopy. Gravimetrical mixing was done by adding 0.1–40% oleic acids in neutralized N. sativa oil containing 0.1% FFA. FTIR spectroscopy technique and partial least square (PLS) calibration were used to detect the absorption region of carbonyl (C=O) which is in the range of 1690–1727 cm−1. The results of P...

  4. Implantes angulados en la rehabilitación parcial de sectores posteriores en maxilares atróficos

    OpenAIRE

    Casar Espinosa, Juan Carlos

    2015-01-01

    Introducción: Tras la pérdida dental se producen una serie de cambios anatómicos que dificultan rehabilitación de los sectores posteriores en maxilares atróficos. Actualmente tenemos diferentes alternativas quirúrgicas para solventar estos problemas, como pueden ser las técnicas de elevación de seno maxilar, tanto con técnicas convencionales como con el empleo de osteotomos o las técnicas M.I.A.M.B.E. Otras alternativas pueden ser el empleo de injertos óseos, las rehabilitaciones con cant...

  5. The Mismatch-Binding Factor MutSβ Can Mediate ATR Activation in Response to DNA Double-Strand Breaks

    Czech Academy of Sciences Publication Activity Database

    Burdová, Kamila; Mihaljevic, B.; Sturzenegger, A.; Chappidi, N.; Janščák, Pavel

    2015-01-01

    Roč. 59, č. 4 (2015), s. 603-614. ISSN 1097-2765 R&D Projects: GA ČR GAP305/10/0281; GA ČR(CZ) GA14-05743S Grant ostatní: Oncosuisse(CH) KLS-02344-02-2009; Swiss National Science Foundation(CH) 31003A_146206; Novartis Foundation for Medical and Biological Research(CH) 11A16 Institutional support: RVO:68378050 Keywords : Ataxia telangiectasia-mutated and Rad3-related (ATR) protein kinase * DNA-damage response * DNA Double-Strand Breaks Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 14.018, year: 2014

  6. ATR-analysaattori raaka-aineen laadunvarmistuksessa : Kasviöljyseoksen peroksidiluvun määrittäminen

    OpenAIRE

    Oinonen, Iida

    2016-01-01

    Tämän opinnäytetyön toimeksiantajana toimi Valio Oy Turengin tehtaan laadunvalvontalaboratorio. Opinnäytetyön tarkoituksena oli selvittää Thermo ScientificTM Nicolet iSTM 50 -analysaattorin ATR-mittausmoduulin käyttömahdollisuuksia raaka-aineen laadunvarmistuksessa. Tavoite oli kehittää laitteelle menetelmä, jonka avulla lastenruokien raaka-aineiden laatua voidaan tehtaalla jatkossa entistä sujuvammin valvoa. Tutkittaviksi raaka-aineiksi haluttiin lastenruoissa käytettävät jauheet, vitam...

  7. ATR FT-IR spectroscopy on Vmh2 hydrophobin self-assembled layers for Teflon membrane bio-functionalization

    International Nuclear Information System (INIS)

    Graphical abstract: - Highlights: • Hydrophobin self-assembled layers on Teflon in different preparation conditions were investigated. • ATR collection data geometry allowed samples examination without any particular preparation. • Amide content, lipid/amide and carbohydrate/amide ratios of the protein layer were estimated. • Secondary structure of protein was determined for the examined samples. • FT-IR demonstrated to be of extreme relevance in monitoring hydrophobin self-assembled layers preparation. - Abstract: Surface functionalization by layers of hydrophobins, amphiphilic proteins produced by fungi offers a promising and green strategy for fabrication of biomedical and bioanalytical devices. The layering process of the Vmh2 hydrophobin from Pleurotus ostreatus on Teflon membrane has been investigated by Attenuated Total Reflection Fourier Transform Infrared (ATR FT-IR) spectroscopy. In particular, protein layers obtained with hydrophobin purified with two different procedures and in various coating conditions have been examined. The layers have been characterized by quantifying the amide I and amide II band area together with the lipid/amide ratio and carbohydrate/amide ratio. This characterization can be very useful in evaluating the best purification strategy and coating conditions. Moreover the analysis of the secondary structure of the layered protein using the deconvolution procedure of amide I band indicate the prevalent contribution from β-sheet state. The results inferred by infrared spectroscopy have been also confirmed by scanning electron microscopy imaging

  8. In-situ monitoring of blood glucose level for dialysis machine by AAA-battery-size ATR Fourier spectroscopy

    Science.gov (United States)

    Hosono, Satsuki; Sato, Shun; Ishida, Akane; Suzuki, Yo; Inohara, Daichi; Nogo, Kosuke; Abeygunawardhana, Pradeep K.; Suzuki, Satoru; Nishiyama, Akira; Wada, Kenji; Ishimaru, Ichiro

    2015-07-01

    For blood glucose level measurement of dialysis machines, we proposed AAA-battery-size ATR (Attenuated total reflection) Fourier spectroscopy in middle infrared light region. The proposed one-shot Fourier spectroscopic imaging is a near-common path and spatial phase-shift interferometer with high time resolution. Because numerous number of spectral data that is 60 (= camera frame rare e.g. 60[Hz]) multiplied by pixel number could be obtained in 1[sec.], statistical-averaging improvement realize high-accurate spectral measurement. We evaluated the quantitative accuracy of our proposed method for measuring glucose concentration in near-infrared light region with liquid cells. We confirmed that absorbance at 1600[nm] had high correlations with glucose concentrations (correlation coefficient: 0.92). But to measure whole-blood, complex light phenomenon caused from red blood cells, that is scattering and multiple reflection or so, deteriorate spectral data. Thus, we also proposed the ultrasound-assisted spectroscopic imaging that traps particles at standing-wave node. Thus, if ATR prism is oscillated mechanically, anti-node area is generated around evanescent light field on prism surface. By elimination complex light phenomenon of red blood cells, glucose concentration in whole-blood will be quantify with high accuracy. In this report, we successfully trapped red blood cells in normal saline solution with ultrasonic standing wave (frequency: 2[MHz]).

  9. ATR FT-IR spectroscopy on Vmh2 hydrophobin self-assembled layers for Teflon membrane bio-functionalization

    Energy Technology Data Exchange (ETDEWEB)

    Portaccio, M., E-mail: marianna.portaccio@unina2.it [Dipartimento di Medicina Sperimentale – Seconda Università di Napoli, Via S.M. di Costantinopoli, 16-80134 Napoli (Italy); Gravagnuolo, A.M., E-mail: alfredomaria.gravagnuolo@unina.it [Dipartimento di Scienze Chimiche, Università “Federico II”, Via Cintia, 21- 80126 Napoli (Italy); Longobardi, S., E-mail: sara.longobardi@unina.it [Dipartimento di Scienze Chimiche, Università “Federico II”, Via Cintia, 21- 80126 Napoli (Italy); Giardina, P., E-mail: paola.giardina@unina.it [Dipartimento di Scienze Chimiche, Università “Federico II”, Via Cintia, 21- 80126 Napoli (Italy); Rea, I., E-mail: ilaria.rea@na.imm.cnr.it [Institute for Microelectronics and Microsystems, CNR, Via P. Castellino, 111-80131 Napoli (Italy); De Stefano, L., E-mail: luca.destefano@na.imm.cnr.it [Institute for Microelectronics and Microsystems, CNR, Via P. Castellino, 111-80131 Napoli (Italy); Cammarota, M., E-mail: marcella.cammarota@unina2.it [Dipartimento di Medicina Sperimentale – Seconda Università di Napoli, Via S.M. di Costantinopoli, 16-80134 Napoli (Italy); Lepore, M., E-mail: maria.lepore@unina2.it [Dipartimento di Medicina Sperimentale – Seconda Università di Napoli, Via S.M. di Costantinopoli, 16-80134 Napoli (Italy)

    2015-10-01

    Graphical abstract: - Highlights: • Hydrophobin self-assembled layers on Teflon in different preparation conditions were investigated. • ATR collection data geometry allowed samples examination without any particular preparation. • Amide content, lipid/amide and carbohydrate/amide ratios of the protein layer were estimated. • Secondary structure of protein was determined for the examined samples. • FT-IR demonstrated to be of extreme relevance in monitoring hydrophobin self-assembled layers preparation. - Abstract: Surface functionalization by layers of hydrophobins, amphiphilic proteins produced by fungi offers a promising and green strategy for fabrication of biomedical and bioanalytical devices. The layering process of the Vmh2 hydrophobin from Pleurotus ostreatus on Teflon membrane has been investigated by Attenuated Total Reflection Fourier Transform Infrared (ATR FT-IR) spectroscopy. In particular, protein layers obtained with hydrophobin purified with two different procedures and in various coating conditions have been examined. The layers have been characterized by quantifying the amide I and amide II band area together with the lipid/amide ratio and carbohydrate/amide ratio. This characterization can be very useful in evaluating the best purification strategy and coating conditions. Moreover the analysis of the secondary structure of the layered protein using the deconvolution procedure of amide I band indicate the prevalent contribution from β-sheet state. The results inferred by infrared spectroscopy have been also confirmed by scanning electron microscopy imaging.

  10. Department of Energy's Advanced Test Reactor (ATR), July 14--18, 1980: An independent on-site safety review

    International Nuclear Information System (INIS)

    The intent of this review was not to conduct a detailed in-depth audit, but rather to make a broad management assessment of ATR operations. The results of the review should only be considered as having identified trends or indications. The Team's observations and recommendations for the most part are based upon standards used for licensed reactor facility practices. These standards form the basis for many of the comments in this report. The Team believes that a uniform minimum standard of performance should be achieved in the operation of DOE reactors. In order to assure that this is accomplished, clear standards are necessary. Consistent with the past AEC and ERDA policy, the Team has used the standards of the commercial nuclear power industry. It is recognized that this approach is conservative, in that the ATR reactor has a significantly greater degree of inherent safety (lower pressure, temperature, power, etc.) than a licensed reactor. Although the Review Team found no indications or evidence that the plant is being operated in an unsafe manner, various areas were identified where improvements are either needed or should be considered to increase the safety of reactor operations

  11. ATR-FTIR spectroscopic studies on density changes of fused silica induced by localized CO2 laser treatment

    Institute of Scientific and Technical Information of China (English)

    张传超; 郑万国; 袁晓东; 张丽娟; 廖威; 晏中华; 陈静; 蒋一岚; 王海军; 栾晓雨; 叶亚云

    2015-01-01

    Surface density changes of the central region of the sites treated by using the CO2 laser-based non-evaporative dam-age mitigation for fused silica are investigated by the attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FTIR). The ATR-FTIR peak shifts of the treated sites of fused silica are monitored to determine the changes of the corresponding density. For the quenching treated sites, the surface density is increased by (0.24±0.01)%compared with the initial density, but the laser annealing by the exposure of a power ramp down after damage mitigation effectively suppresses the structural changes of treated sites, which could reduce the increase of the corresponding density to (0.08±0.01)%. The results provide the sufficient evidence that the laser annealing by a power ramp down after damage mitigation has a positive effect on the control of the structural change induced by CO2 laser-based damage mitigation.

  12. In Situ ATR FTIR Spectroscopic Study of the Formation and Hydration of a Fucoidan/Chitosan Polyelectrolyte Multilayer.

    Science.gov (United States)

    Ho, Tracey T M; Bremmell, Kristen E; Krasowska, Marta; MacWilliams, Stephanie V; Richard, Céline J E; Stringer, Damien N; Beattie, David A

    2015-10-20

    The formation of fucoidan/chitosan-based polyelectrolyte multilayers (PEMs) has been studied with in situ Fourier transform infrared (FTIR) spectroscopy. Attenuated total reflectance (ATR) FTIR spectroscopy has been used to follow the sequential build-up of the multilayer, with peaks characteristic of each polymer being seen to increase in intensity with each respective adsorption stage. In addition, spectral processing has allowed for the extraction of spectra from individual adsorbed layers, which have been used to provide unambiguous determination of the adsorbed mass of the PEM at each stage of formation. The PEM was seen to undergo a transition in growth regimes during build-up: from supra-linear to linear. In addition, the wettability of the PEM has been probed at each stage of the build-up, using the captive bubble contact angle technique. The contact angles were uniformly low, but showed variation in value depending on the nature of the outer polymer layer, and this variation correlated with the overall percentage hydration of the PEM (determined from FTIR and quartz crystal microbalance data). The nature of the hydration water within the polyelectrolyte multilayer has also been studied with FTIR spectroscopy, specifically in situ synchrotron ATR FTIR microscopy of the multilayer confined between two solid surfaces. The acquired spectra have enabled the hydrogen bonding environment of the PEM hydration water to be determined. The PEM hydration water is seen to have an environment in which it is subject to fewer hydrogen bonding interactions than in bulk electrolyte solution. PMID:26421938

  13. Review of reactor physics activities relevant to FBR and ATR programmes in PNC, Japan, June 1977 to October 1978

    International Nuclear Information System (INIS)

    Reactor physics works in Power Reactor and Nuclear Fuel Development Corporation (PNC) are carried out in support of the FBR and ATR development programmes. The works are in progress with high efficiency, in cooperation of other related organizations in Japan and also overseas. The experimental fast reactor ''Joyo'' reached its full power of 50 MWt, being operated now to obtain technical data and experiences. The prototype fast breeder reactor ''Monju'' is nearing completion of its final design, and the surveys on its proposed site have been finished. The advanced thermal reactor ''Fugen'', a heavy water-moderated and boiling light water-cooled, reactor reached the criticality, and the power generation was successfully achieved. The data to be obtained are used for the development of a large demonstration reactor. After describing on these types of reactors briefly, the works on reactor physics are described as follows: for fast reactors, mockup experiment and analysis, evaluation of actinide nuclear data, development of core analytical method, and research on shielding; and for ATR, research with a deuterium critical assembly. (Mori, K.)

  14. Cell cycle-dependent DNA damage signaling induced by ICRF-193 involves ATM, ATR, CHK2, and BRCA1

    International Nuclear Information System (INIS)

    Topoisomerase II is essential for cell proliferation and survival and has been a target of various anticancer drugs. ICRF-193 has long been used as a catalytic inhibitor to study the function of topoisomerase II. Here, we show that ICRF-193 treatment induces DNA damage signaling. Treatment with ICRF-193 induced G2 arrest and DNA damage signaling involving γ-H2AX foci formation and CHK2 phosphorylation. DNA damage by ICRF-193 was further demonstrated by formation of the nuclear foci of 53BP1, NBS1, BRCA1, MDC1, and FANCD2 and increased comet tail moment. The DNA damage signaling induced by ICRF-193 was mediated by ATM and ATR and was restricted to cells in specific cell cycle stages such as S, G2, and mitosis including late and early G1 phases. Downstream signaling of ATM and ATR involved the phosphorylation of CHK2 and BRCA1. Altogether, our results demonstrate that ICRF-193 induces DNA damage signaling in a cell cycle-dependent manner and suggest that topoisomerase II might be essential for the progression of the cell cycle at several stages including DNA decondensation

  15. ATR-IR fingerprinting as a powerful method for identification of traditional medicine samples: a report of 20 herbal patterns

    Directory of Open Access Journals (Sweden)

    A. Sakhteman

    2015-06-01

    Full Text Available Background and objectives: Attenuated total reflectance-inferared (ATR-IR spectra can be used as a non-invasive fingerprinting approach in quality control of herbal samples. Methods: Twenty versatile herbal samples were subjected to attenuated total reflectance-inferared (ATR-IR spectroscopy followed by different clustering methods in order to determine by which method more reasonable classifications would be obtained. Results: All classification methods (K-means, HCA, PCA and SOM were able to discriminate the two medicinal seeds, Hyocyamus niger and Peganum harmala from other herbal samples. Similarly, the starch samples were clustered in a reasonable method. In HCA, one cluster included three types of starch samples: Zea mays, Oryza sativa and Triticum aestivum. All the four classification methods were able to separate Solanum tuberosum starch from other starch samples. HCA and SOM, were able to classify leaf samples Origanum vulgare and Melissa officinalis belonging to Lamiaceae family, in one category. Crocus sativus and its adulterant Carthamus tinctorius flowers were identified by PCA, HCA and SOM as different categories. Conclusion: The result of this study can be utilized for identification and quality control of traditionally used medicinal plant samples in an unknown sample powder. Such data could be the basis for preparing a data bank on Iranian medicinal samples which in turn is used as a simple, fast and reliable method for characterization of herbal powders in Pharmacopoeias.

  16. Role of Bi promotion and solvent in platinum-catalyzed alcohol oxidation probed by in situ X-ray absorption and ATR-IR spectroscopy

    DEFF Research Database (Denmark)

    Mondelli, C.; Grunwaldt, Jan-Dierk; Ferri, D.; Baiker, A.

    2010-01-01

    catalysts under working conditions using in situ X-ray absorption spectroscopy (XAS) and attenuated total reflection infrared spectroscopy (ATR-IR), aiming at uncovering the roles of the metal promoter and the reaction medium. XAS confirms that Bi is oxidized more easily than Pt, maintaining the catalytic...... behaviour is not observed in the presence of Bi, whose geometric effect (site blocking) is interpreted as additionally limiting the adsorption of toluene and the premature deactivation of Pt. ATR-IR spectroscopy during CO adsorption on Pt and during reaction indicates that Bi is located rather on extended...

  17. Quickly Identifying Different Species of Lavender Essential Oils by ATR-FTIR Coupled to PCA and DPLS%ATR-FTIR结合PCA及DPLS快速识别不同品种薰衣草精油

    Institute of Scientific and Technical Information of China (English)

    童红; 唐军; 张正方

    2014-01-01

    筛选有代表性的4个不同品种的96个薰衣草精油样品为试验对象,应用衰减全反射傅里叶变换红外光谱(ATR-FTIR)获得光谱数据,在主成分分析的基础上采用偏最小二乘辨别法(DPLS)建立薰衣草精油品种识别的模型。结果表明:主成分分析基本能实现品种区分,DPLS 法以68个样本作为校正集,交叉验证均方根标准差(RMSEE)为0.1590,以未知的28个样本进行预测,预测均方根标准差(RMSEP)为0.1860,品种识别率为100%,DPLS 法建立的模型对薰衣草精油品种有很好的识别和分类能力。将红外光谱与化学计量学方法结合,可为薰衣草精油品种的优良宏观质控提供一个快速、直观、可行的方法。%Use Attenuated Total Reflectance Fourier Transform Infrared Spectroscopy (ATR-FTIR) to obtain spectral data for classification according to lavender oil cultivars,as a tool to guarantee varie-tal authenticity.96 samples belong to four most representative lavender cultivars.On the basis of PCA,its performance is also compared with that obtained using DPLS model.The results show that PCA can basically discriminate lavender oil cultivar.68 samples are as a calibration set in DPLS method,the RMSEE is 0.1590,28 unknown samples are as predictive samples,the RMSEP is 0. 1860;the correct identification rate of species is 100%.Based on these two data sets only,it seems that the DPLS method is the best of those considered here.The result indicates that a model which provides a quick,intuitive and feasible method has been built to discriminate lavender oils by using ATR-FTIR method combined with chemometrics techniques.

  18. Formation of carboxy- and amide-terminated alkyl monolayers on silicon(111) investigated by ATR-FTIR, XPS, and X-ray scattering: Construction of photoswitchable surfaces

    DEFF Research Database (Denmark)

    Rück-Braun, Karola; Petersen, Michael Åxman; Michalik, Fabian;

    2013-01-01

    -FTIR and XPS studies of the fulgimide samples revealed closely covered amide-terminated SAMs. Reversible photoswitching of the headgroup was read out by applying XPS, ATR-FTIR, and difference absorption spectra in the mid-IR. In XPS, we observed a reversible breathing of the amide/imide C1s and N1s signals...

  19. Revisiting the Brønsted acid catalysed hydrolysis kinetics of polymeric carbohydrates in ionic liquids by in situ ATR-FTIR spectroscopy

    DEFF Research Database (Denmark)

    Kunov-Kruse, Andreas Jonas; Riisager, Anders; Shunmugavel, Saravanamurugan;

    2013-01-01

    A new versatile method to measure rates and determine activation energies for the Brønsted acid catalysed hydrolysis of cellulose and cellobiose (and other polymeric carbohydrates) in ionic liquids is demonstrated by following the C–O stretching band of the glycoside bond with in situ ATR-FTIR. A...

  20. Measuring Heterogeneous Reaction Rates with ATR-FTIR Spectroscopy to Evaluate Chemical Fates in an Atmospheric Environment: A Physical Chemistry and Environmental Chemistry Laboratory Experiment

    Science.gov (United States)

    Roberts, Jason E.; Zeng, Guang; Maron, Marta K.; Mach, Mindy; Dwebi, Iman; Liu, Yong

    2016-01-01

    This paper reports an undergraduate laboratory experiment to measure heterogeneous liquid/gas reaction kinetics (ozone-oleic acid and ozone-phenothrin) using a flow reactor coupled to an attenuated total reflectance-Fourier transform infrared (ATR-FTIR) spectrometer. The experiment is specially designed for an upper-level undergraduate Physical…

  1. Xenopus Cds1 Is Regulated by DNA-Dependent Protein Kinase and ATR during the Cell Cycle Checkpoint Response to Double-Stranded DNA Ends

    Science.gov (United States)

    McSherry, Troy D.; Mueller, Paul R.

    2004-01-01

    The checkpoint kinase Cds1 (Chk2) plays a key role in cell cycle checkpoint responses with functions in cell cycle arrest, DNA repair, and induction of apoptosis. Proper regulation of Cds1 is essential for appropriate cellular responses to checkpoint-inducing insults. While the kinase ATM has been shown to be important in the regulation of human Cds1 (hCds1), here we report that the kinases ATR and DNA-dependent protein kinase (DNA-PK) play more significant roles in the regulation of Xenopus Cds1 (XCds1). Under normal cell cycle conditions, nonactivated XCds1 constitutively associates with a Xenopus ATR complex. The association of XCds1 with this complex does not require a functional forkhead activation domain but does require a putative SH3 binding region that is found in XCds1. In response to double-stranded DNA ends, the amino terminus of XCds1 is rapidly phosphorylated in a sequential pattern. First DNA-PK phosphorylates serine 39, a site not previously recognized as important in Cds1 regulation. Xenopus ATM, ATR, and/or DNA-PK then phosphorylate three consensus serine/glutamine sites. Together, these phosphorylations have the dual function of inducing dissociation from the ATR complex and independently promoting the full activation of XCds1. Thus, the checkpoint-mediated activation of XCds1 requires phosphorylation by multiple phosphoinositide 3-kinase-related kinases, protein-protein dissociation, and autophosphorylation. PMID:15509799

  2. Bacterial and abiotic decay in waterlogged archaeological Picea abies (L.) Karst studied by confocal Raman imaging and ATR-FTIR spectroscopy

    DEFF Research Database (Denmark)

    Pedersen, Nanna Bjerregaard; Gierlinger, Notburga; Thygesen, Lisbeth Garbrecht

    2015-01-01

    Waterlogged archaeological Norway spruce [Picea abies (L.) Karst] poles were studied by means of confocal Raman imaging (CRI) and attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR) analysis to determine lignin and polysaccharide composition and distribution in the cell...

  3. Fabrication Control Plan for ORNL RH-LOCA ATF Test Specimens to be Irradiated in the ATR

    Energy Technology Data Exchange (ETDEWEB)

    Kevin G. Field; Richard Howard; Michael Teague

    2014-06-01

    The purpose of this fabrication plan is (1) to summarize the design of a set of rodlets that will be fabricated and then irradiated in the Advanced Test Reactor (ATR) and (2) provide requirements for fabrication and acceptance criteria for inspections of the Light Water Reactor (LWR) – Accident Tolerant Fuels (ATF) rodlet components. The functional and operational (F&OR) requirements for the ATF program are identified in the ATF Test Plan. The scope of this document only covers fabrication and inspections of rodlet components detailed in drawings 604496 and 604497. It does not cover the assembly of these items to form a completed test irradiation assembly or the inspection of the final assembly, which will be included in a separate INL final test assembly specification/inspection document. The controls support the requirements that the test irradiations must be performed safely and that subsequent examinations must provide valid results.

  4. The Conference Proceedings of the 2001 Air Transport Research Society (ATRS) of the WCTR Society. Volume 1

    Science.gov (United States)

    Lee, Yeong-Heok (Editor); Bowen, Brent D. (Editor); Tarry, Scott E. (Editor)

    2001-01-01

    The ATRS held its Annual conference at Jeju Island, Korea in July 2001. The conference was a success with nearly 140 participants including 70 presenters. This report contains presentations from Volume 1 on the following: Airline and Travel Agent Relationships in Asia;Benchmarking Aviation Safety in the Commercial Airline Industry;Impact of Frequent Flyer Program on the Demand for Air Travel; Application of Genetic Algorithm on Airline Schedule;The Effects of Dual Carrier Designation and Partial Liberalization: The Case of Canada;Defense of Air Carriers and Air Agencies in FAA Enforcement proceedin gs - Damage Control Before the Case Arises; Cost Incentives for Airline Mergers? - An examination on the cost impact of U.S. airline mergers and acquisitions;Airport Regulation, Airline Competition and Canada's Airport System; Airline Competition: The Case of Israel's Domestic Doupoly; Non-Financial Indicators of Airline Distress: A Conceptual Approach;and Airport Privatization: An Empirical Analysis of Financial and Operational Efficiency.

  5. A hybrid original approach for prediction of the aerodynamic coefficients of an ATR-42 scaled wing model

    Directory of Open Access Journals (Sweden)

    Abdallah Ben Mosbah

    2016-02-01

    Full Text Available A new approach for the prediction of lift, drag, and moment coefficients is presented. This approach is based on the support vector machines (SVMs methodology and an optimization meta-heuristic algorithm called extended great deluge (EGD. The novelty of this approach is the hybridization between the SVM and the EGD algorithm. The EGD is used to optimize the SVM parameters. The training and validation of this new identification approach is realized using the aerodynamic coefficients of an ATR-42 wing model. The aerodynamic coefficients data are obtained with the XFoil software and experimental tests using the Price–Païdoussis wind tunnel. The predicted results with our approach are compared with those from the XFoil software and experimental results for different flight cases of angles of attack and Mach numbers. The main purpose of this methodology is to rapidly predict aircraft aerodynamic coefficients.

  6. Formulation and drug-content assay of microencapsulated antisense oligonucleotide to NF-κB using ATR-FTIR

    International Nuclear Information System (INIS)

    Antisense oligonucleotide to NF-κB sequence: 5′-GGA AAC ACA TCC TCC ATG-3′, was microencapsulated in an albumin matrix by the method of spray dryingTM. Spectral analysis was performed on varying drug loading formulations of both drugs by mid-IR attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FTIR). An out of plane O–H bending vibration at 948 cm−1, unique to both the native and microencapsulated drugs was identified. The calculated peak areas corresponded to the drug loadings in the microsphere formulations. A standard curve could then be used to determine the drug content of an unknown microsphere formulation. Accuracy and precision were determined to be comparable to other analytical techniques such as HPLC. (paper)

  7. A distrofia miotônica ou miotonia atrófica: estudo sintético-crítico

    Directory of Open Access Journals (Sweden)

    Enzo Azzi

    1953-03-01

    Full Text Available O autor, baseado em algumas observações clínicas pessoais, individualiza os elementos principais (atróficos, miotônicos, neurendócrino-vegetativos que se referem à distrofia miotônica, insistindo sôbre a riqueza dos sintomas infundíbulo-hipofisários observados (distrofia adiposogenital, policitemia, perturbações do sono, constante hipoplasia da sela turca que falam em favor de uma meiopragia diencéfalo-hipofisária como mecanismo fisiopatogênico da doença. O autor discute também o problema das relações entre distrofia miotônica e miotonia de Thomsen, concluindo, com base em um de seus casos, pela identidade fundamental das duas formas e, portanto, pela sua unificação.

  8. Formulation and drug-content assay of microencapsulated antisense oligonucleotide to NF-κB using ATR-FTIR

    Science.gov (United States)

    Siwale, Rodney; Meadows, Fred; Mody, Vicky V.; Shah, Samit

    2013-09-01

    Antisense oligonucleotide to NF-κB sequence: 5‧-GGA AAC ACA TCC TCC ATG-3‧, was microencapsulated in an albumin matrix by the method of spray dryingTM. Spectral analysis was performed on varying drug loading formulations of both drugs by mid-IR attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FTIR). An out of plane O-H bending vibration at 948 cm-1, unique to both the native and microencapsulated drugs was identified. The calculated peak areas corresponded to the drug loadings in the microsphere formulations. A standard curve could then be used to determine the drug content of an unknown microsphere formulation. Accuracy and precision were determined to be comparable to other analytical techniques such as HPLC.

  9. Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage

    DEFF Research Database (Denmark)

    Syljuåsen, Randi G; Sørensen, Claus Storgaard; Hansen, Lasse Tengbjerg;

    2005-01-01

    -nuclear phosphorylation of histone H2AX, p53, Smc1, replication protein A, and Chk1 itself in human S-phase cells. These phosphorylations were inhibited by ATR siRNA and caffeine, but they occurred independently of ATM. Chk1 inhibition also caused an increased initiation of DNA replication, which was accompanied by...... increased amounts of nonextractable RPA protein, formation of single-stranded DNA, and induction of DNA strand breaks. Moreover, these responses were prevented by siRNA-mediated downregulation of Cdk2 or the replication initiation protein Cdc45, or by addition of the CDK inhibitor roscovitine. We propose...... that Chk1 is required during normal S phase to avoid aberrantly increased initiation of DNA replication, thereby protecting against DNA breakage. These results may help explain why Chk1 is an essential kinase and should be taken into account when drugs to inhibit this kinase are considered for use in...

  10. A Simple Approach to Distinguish Classic and Formaldehyde-Free Tannin Based Rigid Foams by ATR FT-IR

    Directory of Open Access Journals (Sweden)

    Gianluca Tondi

    2015-01-01

    Full Text Available Tannin based rigid foams (TBRFs have been produced with formaldehyde since 1994. Only recently several methods have been developed in order to produce these foams without using formaldehyde. TBRFs with and without formaldehyde are visually indistinguishable; therefore a method for determining the differences between these foams had to be found. The attenuated total reflectance infrared spectroscopy (ATR FT-IR investigation of the TBRFs presented in this paper allowed discrimination between the formaldehyde-containing (classic and formaldehyde-free TBRFs. The spectra of the formaldehyde-free TBRFs, indeed, present decreased band intensity related to the C–O stretching vibration of (i the methylol groups and (ii the furanic rings. This evidence served to prove the chemical difference between the two TBRFs and explained the slightly higher mechanical properties measured for the classic TBRFs.

  11. Changes in the infrared attenuated total reflectance (ATR spectra of lignins from alfalfa stem with growth and development

    Directory of Open Access Journals (Sweden)

    JORDAN P. MARKOVIĆ

    2009-08-01

    Full Text Available Lignin is a poorly characterized polymer and its exact properties vary depending on both the species of the plant and its location within the plant. Three classes of lignins taken from alfalfa stem were examined. The investigation was concentrated on the determination of chemical changes in the lignins during growth and development by the attenuated total reflectance (ATR infrared (IR spectrometric technique. The spectrum of permanganate lignin was comparable to that of acid detergent lignin. The main differences were in the different relative absorbance of the peaks. The predominant component of acid detergent lignin and permanganate lignin was guaiacyl-type lignin. The predominant component of Klason lignin was syringyl-type lignin. A comparison between the signals from lignin in different development stages revealed the appearance of new peaks, which are indications of new bonds and changes in the structure of the lignins.

  12. Association atrésie de l'oesophage type 3 - microcéphalie: Un syndrome de Feingold incomplet?

    OpenAIRE

    Shongo, Mick Yapongombo; Lubala, Toni Kasole; Mbuyi, Sébastien Musanzayi; Makinko, Paul Ilunga; Ngwej, Dieudonné Tshikwej; Kabange, Felix Numbi

    2012-01-01

    L'atrésie de l'oesophage est une des malformations digestive les plus fréquentes en néonatologie. Il existe 5 types anatomiques, selon la présence et le siège de la fistule oeso-trachéale. Le diagnostic anténatal est difficile. A la naissance, le diagnostic est suspecté en salle de travail, devant l’échec du passage systématique d'une sonde digestive jusque dans l'estomac. Des trouble de la déglutition, une hyper sialorrhée, une détresse respiratoire sont ensuite retrouvés. Une fistule oeso-t...

  13. Tensile and impact properties of vanadium-base alloys irradiated at low temperatures in the ATR-A1 experiment

    Energy Technology Data Exchange (ETDEWEB)

    Tsai, H.; Nowicki, L.J.; Billone, M.C.; Chung, H.M.; Smith, D.L. [Argonne National Lab., IL (United States)

    1998-03-01

    Subsize tensile and Charpy specimens made from several V-(4-5)Cr-(4-5)Ti alloys were irradiated in the ATR-A1 experiment to study the effects of low-temperature irradiation on mechanical properties. These specimens were contained in lithium-bonded subcapsules and irradiated at temperatures between {approx}200 and 300 C. Peak neutron damage was {approx}4.7 dpa. Postirradiation testing of these specimens has begun. Preliminary results from a limited number of specimens indicate a significant loss of work-hardening capability and dynamic toughness due to the irradiation. These results are consistent with data from previous low-temperature neutron irradiation experiments on these alloys.

  14. Overview of aerosol properties associated with air masses sampled by the ATR-42 during the EUCAARI campaign (2008)

    Science.gov (United States)

    Crumeyrolle, S.; Schwarzenboeck, A.; Roger, J. C.; Sellegri, K.; Burkhart, J. F.; Stohl, A.; Gomes, L.; Quennehen, B.; Roberts, G.; Weigel, R.; Villani, P.; Pichon, J. M.; Bourrianne, T.; Laj, P.

    2013-05-01

    Within the frame of the European Aerosol Cloud Climate and Air Quality Interactions (EUCAARI) project, the Météo-France aircraft ATR-42 performed 22 research flights over central Europe and the North Sea during the intensive observation period in May 2008. For the campaign, the ATR-42 was equipped to study the aerosol physical, chemical, hygroscopic and optical properties, as well as cloud microphysics. For the 22 research flights, retroplume analyses along the flight tracks were performed with FLEXPART in order to classify air masses into five sectors of origin, allowing for a qualitative evaluation of emission influence on the respective air parcel. This study shows that the extensive aerosol parameters (aerosol mass and number concentrations) show vertical decreasing gradients and in some air masses maximum mass concentrations (mainly organics) in an intermediate layer (1-3 km). The observed mass concentrations (in the boundary layer (BL): between 10 and 30 μg m-3; lower free troposphere (LFT): 0.8 and 14 μg m-3) are high especially in comparison with the 2015 European norms for PM2.5 (25 μg m-3) and with previous airborne studies performed over England (Morgan et al., 2009; McMeeking et al., 2012). Particle number size distributions show a larger fraction of particles in the accumulation size range in the LFT compared to BL. The chemical composition of submicron aerosol particles is dominated by organics in the BL, while ammonium sulphate dominates the submicron aerosols in the LFT, especially in the aerosol particles originated from north-eastern Europe (~ 80%), also experiencing nucleation events along the transport. As a consequence, first the particle CCN acting ability, shown by the CCN/CN ratio, and second the average values of the scattering cross sections of optically active particles (i.e. scattering coefficient divided by the optical active particle concentration) are increased in the LFT compared to BL.

  15. AGR-2 Final Data Qualification Report for U.S. Capsules - ATR Cycles 147A Through 154B

    Energy Technology Data Exchange (ETDEWEB)

    Pham, Binh T; Einerson, Jeffrey J

    2014-07-01

    This report provides the data qualification status of AGR-2 fuel irradiation experimental data in four U.S. capsules from all 15 Advanced Test Reactor (ATR) Cycles 147A, 148A, 148B, 149A, 149B, 150A, 150B, 151A, 151B, 152A, 152B, 153A, 153B, 154A, and 154B, as recorded in the Nuclear Data Management and Analysis System (NDMAS). Thus, this report covers data qualification status for the entire AGR-2 irradiation and will replace four previously issued AGR-2 data qualification reports (e.g., INL/EXT-11-22798, INL/EXT-12-26184, INL/EXT-13-29701, and INL/EXT-13-30750). During AGR-2 irradiation, two cycles, 152A and 153A, occurred when the ATR core was briefly at low power, so AGR-2 irradiation data are not used for physics and thermal calculations. Also, two cycles, 150A and 153B, are Power Axial Locator Mechanism (PALM) cycles when the ATR power is higher than during normal cycles. During the first PALM cycle, 150A, the experiment was temporarily moved from the B-12 location to the ATR water canal and during the second PALM cycle, 153B, the experiment was temporarily moved from the B-12 location to the I-24 location to avoid being overheated. During the “Outage” cycle, 153A, seven flow meters were installed downstream from seven Fission Product Monitoring System (FPMS) monitors to measure flows from the monitors and these data are included in the NDMAS database. The AGR-2 data streams addressed in this report include thermocouple (TC) temperatures, sweep gas data (flow rates including new FPM downstream flows, pressure, and moisture content), and FPMS data (release rates and release-to-birth rate ratios [R/Bs]) for each of the four U.S. capsules in the AGR-2 experiment (Capsules 2, 3, 5, and 6). The final data qualification status for these data streams is determined by a Data Review Committee comprised of AGR technical leads, Very High Temperature Reactor (VHTR) Program Quality Assurance (QA), and NDMAS analysts. The Data Review Committee, which convened just

  16. Low-temperature, low-cost growth of robust ATR GeO2 hollow fibers based on copper capillary tubes for transmission of CO2 laser light

    Science.gov (United States)

    Jing, Chengbin; Bai, Wei; Hu, Zhigao; Yang, Pingxiong; Liu, Aiyun; Lin, Fangtin; Shi, Yiwei; Chu, Junhao

    2014-02-01

    Attenuated total reflectance (ATR) infrared hollow waveguide attracts particular interest since it has both advantages of a hollow fiber and a light guiding mechanism similar to that of solid-core fibers. Presently, ATR hollow waveguides are mainly structured with single-crystal sapphire or glassy materials. These waveguides are somewhat brittle. More robust ATR hollow fibers are required in many military and domestic applications. In this work, ATR GeO2 hollow waveguides were prepared based on a copper capillary tube for transmitting CO2 laser light. The inner wall of the copper structural tube was polished using a high-pressure pulsed nanofluid technique. A hexagonal crystalline GeO2 reflective layer with sufficient thickness (>4 μm) was grown on the inner tube wall via a simple liquid phase deposition process at room temperature. The GeO2 coated copper hollow fiber exhibits a low-loss band within 10-11.5 μm. It can still be bent since the hollow-core size (1.4 mm) and the wall thickness (50 μm) are not too large. The transmissions of CO2 laser light are 91% and 43% under a straight condition and a 90° bend with a 30-cm radius condition, respectively. The waveguide displays high heat-resisting properties due to high thermal conductivity of the copper substrate tube and a high melting point (1115°C) of the GeO2 reflective layer. This work opens a door for low-temperature, low-cost growth of long ATR GeO2 infrared hollow fibers based on various substrate tubes, even including plastic capillary tubes.

  17. AGR-3/4 Data Qualification Report for ATR Cycles 151A, 151B, 152A, 152B, 154A, and 154B

    Energy Technology Data Exchange (ETDEWEB)

    Binh T. Pham

    2014-02-01

    This data report provides the qualification status of Advanced Gas Reactor-3/4 (AGR-3/4) fuel irradiation experimental data from Advanced Test Reactor (ATR) Cycles 151A, 151B, 152A, 152B, 154A, and 154B, as recorded in the Nuclear Data Management and Analysis System (NDMAS). Of these cycles, ATR Cycle 152A is a low power cycle that occurred when the ATR core was briefly at low power. The irradiation data are not used for physics and thermal calculation, but the qualification status of these cycle data is still covered in this report. On the other hand, during ATR Cycles 153A (unplanned Outage cycle) and 153B (Power Axial Locator Mechanism [PALM] cycle), the AGR-3/4 was pulled out from the ATR core and stored in the canal to avoid being overheated. Therefore, qualification of the AGR-3/4 irradiation data from these 2 cycles was excluded in this report. By the end of ATR Cycle 154B, AGR-3/4 was irradiated for a total of 264.1 effective full power days. The AGR-3/4 data streams addressed in this report include thermocouple (TC) temperatures, sweep gas data (flow rates, pressure, and moisture content), and Fission Product Monitoring System (FPMS) data (release rates and release-to-birth rate ratios [R/Bs]) for each of the twelve capsules in the AGR-3/4 experiment. The final data qualification status for these data streams is determined by a Data Review Committee (DRC) composed of AGR technical leads, Sitewide Quality Assurance (QA), and NDMAS analysts. The DRC convened on February 12, 2014, reviewed the data acquisition process, and considered whether the data met the requirements for data collection as specified in QA-approved Very High Temperature Reactor (VHTR) Technology Development Office (TDO) data collection plans. The DRC also examined the results of NDMAS data testing and statistical analyses, and confirmed the qualification status of the data as given in this report.

  18. Investigation of aged Asian dust particles by the combined use of quantitative ED-EPMA and ATR-FTIR imaging

    Directory of Open Access Journals (Sweden)

    Y.-C. Song

    2013-03-01

    Full Text Available In our previous works, it was demonstrated that the combined use of quantitative energy-dispersive electron probe X-ray microanalysis (ED-EPMA, which is also known as low-Z particle EPMA, and attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR imaging has great potential for a detailed characterization of individual aerosol particles. In this study, extensively chemically modified (aged individual Asian dust particles collected during an Asian dust storm event on 11 November 2002 in Korea were characterized by the combined use of low-Z particle EPMA and ATR-FTIR imaging. Overall, 109 individual particles were classified into four particle types based on their morphology, elemental concentrations, and molecular species and/or functional groups of individual particles available from the two analytical techniques: Ca-containing (38%, NaNO3-containing (30%, silicate (22%, and miscellaneous particles (10%. Among the 41 Ca-containing particles, 10, 8, and 14 particles contained nitrate, sulfate, and both, respectively, whereas only two particles contained unreacted CaCO3. Airborne amorphous calcium carbonate (ACC particles were observed in this Asian dust sample for the first time, where their IR peaks for the insufficient symmetric environment of CO32− ions of ACC were clearly differentiated from those of crystalline CaCO3. This paper also reports the first inland field observation of CaCl2 particles probably converted from CaCO3 through the reaction with HCl(g. HCl(g was likely released from the reaction of sea salt with NOx/HNO3, as all 33 particles of marine origin contained NaNO3 (no genuine sea salt particle was encountered. Some silicate particles with minor amounts of calcium were observed to be mixed with nitrate, sulfate, and water. Among 24 silicate particles, 10 particles are mixed with water, the presence of which could facilitate atmospheric heterogeneous reactions of silicate particles including swelling

  19. Overview of aerosol properties associated with air masses sampled by the ATR-42 during the EUCAARI campaign (2008

    Directory of Open Access Journals (Sweden)

    S. Crumeyrolle

    2012-04-01

    Full Text Available Within the frame of the European Aerosol Cloud Climate and Air Quality Interactions (EUCAARI project the Météo-France aircraft ATR-42 performed 22 research flights, over central Europe and the North Sea during the intensive observation period in May 2008. For the campaign, the ATR-42 was equipped in order to study aerosol physical, chemical and optical properties, as well as cloud microphysics. During the campaign, continental air masses from Eastern and Western Europe were encountered, along with polar and Scandinavian air masses. For the 22 research flights, retroplume analyses along the flight tracks were performed with FLEXPART in order to classify air masses into five sectors of origin which allows for a qualitative evaluation of emission influence on the respective air parcel.

    In the polluted boundary layer (BL, typical concentrations of particles with diameters larger than 10 nm (N10 are of the order of 5000–6000 cm−3, whereas N10 concentrations of clean air masses were lower than 1300 cm−3. The detection of the largest particle number concentrations occurred in air masses coming from Polar and Scandinavian regions for which an elevated number of nucleation mode (25–28 nm particles was observed and attributed to new particle formation over open sea. In the free troposphere (FT, typical observed N10 are of the order of 900 cm−3 in polluted air masses and 400–600 cm−3 in clean air masses, respectively. In both layers, the chemical composition of submicron aerosol particles is dominated by organic matter and nitrate in polluted air masses, while, sulphate and ammonium followed by organics dominate the submicron aerosols in clean air masses. The highest CCN/CN ratios were observed within the polar air masses while the CCN concentration values are the highest within the polluted air masses.

    Within the five air mass sectors defined

  20. Caracterització fenotípica i assaig terapèutic en models murins transgènics d'atròfia muscular espinal

    OpenAIRE

    Dachs i Cabanas, Elisabet

    2012-01-01

    L’atròfia muscular espinal (AME) és una malaltia d’origen genètic que afecta, majoritàriament a la població infantil. La malaltia cursa amb una mort de les motoneurones  i atròfia muscular. El gen implicat és el survival motor neuron (SMN) que està delecionat en un 95% dels casos. El nostre estudi està dividit en dues parts: 1- l’aprofundiment de les alteracions musculars en dos models animals murins transgènics que pateixen les formes més greus d’AME (Tipus 1-2) i 2- estudi dels possibles e...

  1. In situ ATR-FTIR study of H2O and D2O adsorption on TiO2 under UV irradiation.

    Science.gov (United States)

    Belhadj, Hamza; Hakki, Amer; Robertson, Peter K J; Bahnemann, Detlef W

    2015-09-21

    The adsorption of water and deuterium oxide on TiO2 surfaces was investigated in the dark as well as under UV(A) irradiation using in situ ATR-FTIR spectroscopy under oxygen and oxygen free conditions. Adsorption of H2O-D2O mixtures revealed an isotopic exchange reaction occurring onto the surface of TiO2 in the dark. Under UV(A) irradiation, the amount of both OH and OD groups was found to be increased by the presence of molecular oxygen. Furthermore, the photocatalytic formation of hydroperoxide under oxygenated condition has been recorded utilizing Attenuated Total Reflection Fourier Transformed Infrared (ATR-FTIR) spectroscopy which appeared as new band at 3483 cm(-1). Different possible mechanisms are discussed in terms of the source of hydroxyl groups formed and/or hydration water on the TiO2 surface for the photocatalytic reaction and photoinduced hydrophilicity. PMID:26266701

  2. DETERMINATION OF THE QUANTITY OF I-135 RELEASED FROM THE AGR-1 TEST FUELS AT THE END OF ATR OPERATING CYCLE 138B

    Energy Technology Data Exchange (ETDEWEB)

    J. K. Hartwell; D. M. Scates; J. B. Walter; M. W. Drigert

    2007-05-01

    The AGR-1 experiment is a multiple fueled-capsule irradiation experiment being conducted in the Advanced Test Reactor (ATR) in support of the Advanced Gas Reactor (AGR) Fuel Development and Qualification Program. The experiment began irradiation in the ATR with a cycle that reached full power on December 26, 2006 and ended with shutdown of the reactor for a brief outage on February 10, 2007 at 0900. The AGR-1 experiment will continue cyclical irradiation for about 2.5 years. In order to allow estimation of the amount of radioiodine released during the first cycle, purge gas flow to all capsules continued for about 4 days after reactor shutdown. The FPMS data acquired during part of that shutdown flow period has been analyzed to elucidate the level of 135I released during the operating cycle.

  3. ATR-FTIR spectroscopy detects alterations induced by organotin(IV) carboxylates in MCF-7 cells at sub-cytotoxic/-genotoxic concentrations

    CERN Document Server

    Ahmad, Muhammad S; Hussain, Mukhtiar; Hanif, Muhammad; Ali, Saqib; Walsh, Michael J; Martin, Francis L; 10.1186/1757-5036-1-3

    2009-01-01

    The environmental impact of metal complexes such as organotin(IV) compounds is of increasing concern. Genotoxic effects of organotin(IV) compounds (0.01 microg/ml, 0.1 microg/ml or 1.0 microg/ml) were measured using the alkaline single-cell gel electrophoresis (comet) assay to measure DNA single-strand breaks (SSBs) and the cytokinesis-block micronucleus (CBMN) assay to determine micronucleus formation. Biochemical-cell signatures were also ascertained using attenuated total reflection Fourier-transform infrared (ATR-FTIR) spectroscopy. In the comet assay, organotin(IV) carboxylates induced significantly-elevated levels of DNA SSBs. Elevated micronucleus-forming activities were also observed. Following interrogation using ATR-FTIR spectroscopy, infrared spectra in the biomolecular range (900 cm-1 - 1800 cm-1) derived from orga...

  4. Fourier transform infrared-attenuated total reflectance (FTIR-ATR) spectroscopy and chemometric techniques for the determination of adulteration in petrodiesel/biodiesel blends

    OpenAIRE

    Armando Guerrero Peña; Francisco Anguebes Franseschi; Mepivoseth Castelán Estrada; Victorino Morales Ramos; Reyes García Zarracino; José C. Zavala Loría; Atl V. Córdova Quiroz

    2014-01-01

    We propose an analytical method based on fourier transform infrared-attenuated total reflectance (FTIR-ATR) spectroscopy to detect the adulteration of petrodiesel and petrodiesel/palm biodiesel blends with African crude palm oil. The infrared spectral fingerprints from the sample analysis were used to perform principal components analysis (PCA) and to construct a prediction model using partial least squares (PLS) regression. The PCA results separated the samples into three groups, allowing id...

  5. Understanding the Crystallinity Indices Behavior of Burned Bones and Teeth by ATR-IR and XRD in the Presence of Bioapatite Mixed with Other Phosphate and Carbonate Phases

    OpenAIRE

    Giampaolo Piga; David Gonçalves; T. J. U. Thompson; Antonio Brunetti; Assumpció Malgosa; Stefano Enzo

    2016-01-01

    We have critically investigated the ATR-IR spectroscopy data behavior of burned human teeth as opposed to the generally observed behavior in human bones that were subjected to heat treatment, whether deliberate or accidental. It is shown that the deterioration of the crystallinity index (CI) behavior sometimes observed in bones subjected to high temperature appears to be of higher frequency in the case of bioapatite from teeth. This occurs because the formation of the β-tricalcium phosphate (...

  6. Adsorption of poly(ethylene oxide)-block-poly(D,L-lactide) copolymers on polyactide surface studied by ATR-FTIR spectroscopy

    Czech Academy of Sciences Publication Activity Database

    Popelka, Štěpán; Machová, Luďka; Rypáček, František

    Prague: Czech Society for New Materials and Technologies, 2005. Poster Session II. [European Congress on Advanced Materials and Processes. 5.9.2005-8.9.2005, Prague] R&D Projects: GA AV ČR IAA4050202 Keywords : ATR FTIR * polylactide * surface Subject RIV: CD - Macromolecular Chemistry http://webdb.dgm.de/dgm_lit/prg/FMPro?-db=w_program&-recID=12953608&- format =prog_kurzfassung.htm&-lay=Standard&-find

  7. A DNA Damage Response Screen Identifies RHINO: a 9-1-1 and TopBP1 interacting protein required for ATR signaling

    OpenAIRE

    Cotta-Ramusino, Cecilia; 3, E. Robert McDonald; Hurov, Kristen; Sowa, Mathew E.; Harper, J. Wade; Elledge, Stephen J.

    2011-01-01

    The DNA damage response (DDR) is a protein kinase cascade that orchestrates DNA repair processes via transcriptional and post-translational mechanisms. Cell cycle arrest is a hallmark of the DDR. We performed a damage-induced cell cycle arrest screen and uncovered a critical role for Fanconi anemia (FA) and homologous recombination (HR) proteins in ATR signaling. HR was required to maintain prolonged cell cycle arrest and to prevent massive genomic instability. Over 100 high scoring DDR candi...

  8. Kinetic investigations on UV-induced photopolymerization reactions by real-time FTIR-ATR spectroscopy: the efficiency of photoinitiators at 313 and 222 nm

    International Nuclear Information System (INIS)

    Real-time FTIR-ATR spectroscopy was used to study the kinetics of photopolymerization reactions induced by monochromatic UV light. Various photoinitiators with a broad range of extinction coefficients were tested for their efficiency to start the curing reaction of a diacrylate on irradiation at 313 or 222 nm. The effect of the absorption and initiation properties of the photoinitiators on the polymerization rate was analyzed. At 222 nm, the acrylate was found to polymerize even without photoinitiator

  9. Quantification of pure refined olive oil adulterant in extra virgin olive oil using diamond cell atr-ftir spectroscopy

    International Nuclear Information System (INIS)

    The present study depicts spectroscopic method development to deliver a rapid, simple and reproducible quantification of pure refined olive oil (PROO) adulterant in extra virgin olive oil (EVOO) using partial least square (PLS) regression (statistical parameter). Single bounce attenuated total reflectance (SB-ATR) Fourier transform infrared (FTIR) was choice in the developed method. Blended standards of PROO and EVOO were obtained by their weight by weight percentage and the values were used to construct calibration curves for quantification. The optimum regression values (i.e. >0.99) were achieved using the combined frequencies of 3105-2761, 1838-1687, and 1482-440 cm-1 with regression coefficients (R2) 0.99718 and achieved residual mean square error of calibration (RMSEC) 1.40% w/w. To determine the suitability of developed method principal component spectra (PCS) diagnostic was also used. The results of the present study prove that the developed methods reported in preceding studies can be good option for more rapid and accurate determination of PROO adulteration in EVOO. (author)

  10. Improving batch cooling seeded crystallization of an organic weed-killer using on-line ATR FTIR measurement of supersaturation

    Science.gov (United States)

    Lewiner, F.; Févotte, G.; Klein, J. P.; Puel, F.

    2001-06-01

    In previous papers, a method for the calibration of ATR FTIR measurement of dissolved solid concentration during cooling crystallizations was presented, and efficient basic procedures for the determination of solubility and metastability curves were described. The present paper reports new experimental results. The crystallization of an organic product is studied thanks to on-line FTIR measurements of supersaturation and off-line crystal size distribution (CSD) determinations. The obtained information is shown to potentially allow a deeper examination of major industrial issues such as the reduction of batch-to-batch variations and the improvement of the CSD of the final particles. A particular attention is focused on the determination of appropriate seeding parameters such as the cooling rate of seeded slurries, the temperature of introduction and the amount of seed. The results obtained demonstrate that, although any modelling approach is outside the scope of this paper, the analysis of the measured supersaturation profiles allows some interpretation of mechanisms governing the final CSD, and consequently, the proposal of improved operating parameters.

  11. The Conference Proceedings of the 2001 Air Transport Research Society (ATRS) of the WCTR Society. Volume 2

    Science.gov (United States)

    Lee, Yeong-Heok (Editor); Bowen, Brent D. (Editor); Tarry, Scott E. (Editor)

    2001-01-01

    The ATRS held its 5th Annual conference at the City University of Hong Kong Campus in July 2001. The conference was a success with nearly 140 participants including 70 presenters. Titles that comprise Volume 2 include: Intelligent Airport Gate Assignment System; A Study on the Effects of the Personality Compatibility to the Job Performance; ITS/CVO Application for Air cargo Transportation in Korea; An Airport as a Logistics and Economic Hub: The Case of Incheon International Airport; The Impact Of Aviation Safety over the Consumer's Behavior; The Integration of China and Taiwan Air Networks for Direct Air Cargo Services; Quality perception and carrier choice in Civil Aviation; Future Trends in Business Travel Decision Making; Cooperation Among German Airports in Europe; Inbound and Outbound Air Passenger Traffic Forecasting between the United States and Selected Asian countries; An Evaluation of Alternative Facilities for Airport Redevelopment using Fuzzy Linguistic Approach; Economic Analysis of Airline Alliances; The Aviation Cooperation between the two Koreas Preparing for the Reunification of the Peninsula; and A Study on the Air Transport Cooperation in Northeast Asia between China, Japan and Korea.

  12. Adsorption of Lysine on Na-Montmorillonite and Competition with Ca(2+): A Combined XRD and ATR-FTIR Study.

    Science.gov (United States)

    Yang, Yanli; Wang, Shengrui; Liu, Jingyang; Xu, Yisheng; Zhou, Xiaoyun

    2016-05-17

    Lysine adsorption at clay/aqueous interfaces plays an important role in the mobility, bioavailability, and degradation of amino acids in the environment. Knowledge of these interfacial interactions facilitates our full understanding of the fate and transport of amino acids. Here, X-ray diffraction (XRD) and attenuated total reflectance Fourier-transform infrared spectroscopy (ATR-FTIR) measurements were used to explore the dynamic process of lysine adsorption on montmorillonite and the competition with Ca(2+) at the molecular level. Density functional theory (DFT) calculations were employed to determine the peak assignments of dissolved lysine in the solution phase. Three surface complexes, including dicationic, cationic, and zwitterionic structures, were observed to attach to the clay edge sites and penetrate the interlayer space. The increased surface coverage and Ca(2+) competition did not affect the interfacial lysine structures at a certain pH, whereas an elevated lysine concentration contributed to zwitterionic-type coordination at pH 10. Moreover, clay dissolution at pH 4 could be inhibited at a higher surface coverage with 5 and 10 mM lysine, whereas the inhibition effect was inconspicuous or undetected at pH 7 and 10. The presence of Ca(2+) not only could remove a part of the adsorbed lysine but also could facilitate the readsorption of dissolved Si(4+) and Al(3+) and surface protonation. Our results provide new insights into the process of lysine adsorption and its effects on montmorillonite surface sites. PMID:27118104

  13. Characterization of nasal paraffinoma following septorhinoplasty by attenuated total reflection--fourier transform infrared spectroscopy (ATR-FTIR).

    Science.gov (United States)

    Gil-Carcedo, Luis M; Martín-Gil, Jesús; Gil-Carcedo, Elisa S; Vallejo, Luis A; Martín-Gil, Francisco J

    2006-06-01

    Vaseline and paraffin have been injected into various parts of the body. Vaselinoma and paraffinoma are well-described complications, despite which nasal packing with Vaseline gauze is still common in the management of epistaxis, after rhinoplasty, endonasal surgery, to control bleeding and prevent synechiae or restenosis. Our aim is to highlight this complication, propose a safe method for its diagnosis and establish guidelines for its prevention. We report two cases of paraffinoma occurring after rhinoplasty and discuss prevention of this rare but serious complication, and suggest an alternative dressing. Attenuated total reflection (ATR) FI7R spectra have proven to be a definitive characterising tool for surgical extracts, guaranteeing detection of mineral products that histology does not offer. For these lesions we propose the name "petroleum oilomas" which we feel to be more appropriate than the more commonly used paraffinomas. Relevance of the work: a description of an innovative and safe method of diagnosis, and proposal of a procedure for postrhinoplasty packing (without mineral oils) to avoid this complication. PMID:16792177

  14. Evaluation of Salmon Adhesion on PET-Metal Interface by ATR, FT-IR, and Raman Spectroscopy

    Directory of Open Access Journals (Sweden)

    E. Zumelzu

    2015-01-01

    Full Text Available The material employed in this study is an ecoefficient, environmentally friendly, chromium (VI-free (noncarcinogenic metal polymer. The originality of the research lies in the study of the effect of new production procedures of salmon on metal packaging with multilayer polyethylene terephthalate (PET polymer coatings. Our hypothesis states that the adhesion of postmortem salmon muscles to the PET polymer coating produces surface and structural changes that affect the functionality and limit the useful life of metal containers, compromising therefore their recycling capacity as ecomaterials. This work is focused on studying the effects of the biochemical changes of postmortem salmon on the PET coating and how muscle degradation favors adhesion to the container. The experimental design considered a series of laboratory tests of containers simulating the conditions of canned salmon, chemical and physical tests of food-contact canning to evaluate the adhesion, and characterization of changes in the multilayer PET polymer by electron microscopy, ATR, FT-IR, and Raman spectroscopy analyses. The analyses determined the effect of heat treatment of containers on the loss of freshness of canned fish and the increased adhesion to the container wall, and the limited capability of the urea treatment to remove salmon muscle from the container for recycling purposes.

  15. Evaluating drug delivery with salt formation: Drug disproportionation studied in situ by ATR-FTIR imaging and Raman mapping.

    Science.gov (United States)

    Ewing, Andrew V; Wray, Patrick S; Clarke, Graham S; Kazarian, Sergei G

    2015-01-01

    Two different vibrational spectroscopic approaches, ATR-FTIR spectroscopic imaging and Raman mapping, were used to investigate the components within a tablet containing an ionised drug during dissolution experiments. Delivering certain drugs in their salt form is a method that can be used to improve the bioavailability and dissolution of the poorly aqueous soluble materials. However, these ionised species have a propensity to covert back to their thermodynamically favourable free acid or base forms. Dissolution experiments of the ionised drug in different aqueous media resulted in conversion to the more poorly soluble free acid form, which is detrimental for controlled drug release. This study investigates the chemical changes occurring to formulations containing a development ionised drug (37% by weight), in different aqueous pH environments. Firstly, dissolution in a neutral medium was studied, showing that there was clear release of ionised monosodium form of the drug from the tablet as it swelled in the aqueous medium. There was no presence of any drug in the monohydrate free acid form detected in these experiments. Dissolution in an acidic (0.1M HCl) solution showed disproportionation forming the free acid form. Disproportionation occurred rapidly upon contact with the acidic solution, initially resulting in a shell of the monohydrate free acid form around the tablet edges. This slowed ingress of the solution into the tablet before full conversion of the ionised form to the free acid form was characterised in the spectroscopic data. PMID:25910459

  16. Determination of surface concentrations of individual molecule-layers used in nanoscale biosensors by in situ ATR-FTIR spectroscopy

    KAUST Repository

    Punzet, Manuel

    2012-01-01

    For the development of nanowire sensors for chemical and medical detection purposes, the optimal functionalization of the surface is a mandatory component. Quantitative ATR-FTIR spectroscopy was used in situ to investigate the step-by-step layer formation of typical functionalization protocols and to determine the respective molecule surface concentrations. BSA, anti-TNF-α and anti-PSA antibodies were bound via 3-(trimethoxy)butylsilyl aldehyde linkers to silicon-oxide surfaces in order to investigate surface functionalization of nanowires. Maximum determined surface concentrations were 7.17 × 10 -13 mol cm -2 for BSA, 1.7 × 10 -13 mol cm -2 for anti-TNF-α antibody, 6.1 × 10 -13 mol cm -2 for anti-PSA antibody, 3.88 × 10 -13 mol cm -2 for TNF-α and 7.0 × 10 -13 mol cm -2 for PSA. Furthermore we performed antibody-antigen binding experiments and determined the specific binding ratios. The maximum possible ratio of 2 was obtained at bulk concentrations of the antigen in the μg ml -1 range for TNF-α and PSA. © 2012 The Royal Society of Chemistry.

  17. Mismatch repair-dependent G2 checkpoint induced by low doses of SN1 type methylating agents requires the ATR kinase.

    Science.gov (United States)

    Stojic, Lovorka; Mojas, Nina; Cejka, Petr; Di Pietro, Massimiliano; Ferrari, Stefano; Marra, Giancarlo; Jiricny, Josef

    2004-06-01

    S(N)1-type alkylating agents represent an important class of chemotherapeutics, but the molecular mechanisms underlying their cytotoxicity are unknown. Thus, although these substances modify predominantly purine nitrogen atoms, their toxicity appears to result from the processing of O(6)-methylguanine ((6Me)G)-containing mispairs by the mismatch repair (MMR) system, because cells with defective MMR are highly resistant to killing by these agents. In an attempt to understand the role of the MMR system in the molecular transactions underlying the toxicity of alkylating agents, we studied the response of human MMR-proficient and MMR-deficient cells to low concentrations of the prototypic methylating agent N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). We now show that MNNG treatment induced a cell cycle arrest that was absolutely dependent on functional MMR. Unusually, the cells arrested only in the second G(2) phase after treatment. Downstream targets of both ATM (Ataxia telangiectasia mutated) and ATR (ATM and Rad3-related) kinases were modified, but only the ablation of ATR, or the inhibition of CHK1, attenuated the arrest. The checkpoint activation was accompanied by the formation of nuclear foci containing the signaling and repair proteins ATR, the S(*)/T(*)Q substrate, gamma-H2AX, and replication protein A (RPA). The persistence of these foci implied that they may represent sites of irreparable damage. PMID:15175264

  18. Study in vitro of Er,Cr:YSGG laser effects in bone tissue by ATR-FTIR spectroscopy

    International Nuclear Information System (INIS)

    Laser proves to be, more and more, an effective tool for helping health professionals, being intensively used in ophthalmological and odontological procedures. In particular, high-density, infrared emitting lasers have great potential in cutting mineralized biological hard tissues, given their high absorption by hydroxyapatite and water, these tissues' main components. In comparison to mechanical instruments, laser presents a series of advantages, namely, smaller damage to the remaining tissue and promotion of homeostatic effect, apart from making it possible to execute procedures in areas with difficult access. However, for an efficient and safe use of this technique, it is necessary to know the effects of the laser irradiation on the tissue. The Fourier transform infrared (FTIR) technique is heavily used in the study of organic materials, because apart from making it possible to identify the materials' components, it also allows to prepare a semi quantitative analysis. This work aims to establish the ATR-FTIR technique in the characterization of natural and irradiated osseous tissue, and to verify the possible chemical and structural changes caused by irradiation. Firstly, the best conditions for the obtainment of bone sample spectra were determined. Then, bone samples, irradiated with the Er,Cr:YSGG (2,78 μm) infrared emitting laser (adjusted with different energy densities) were analyzed alongside with natural bone samples. It has been verified that the technique is effective in the bone tissue characterization, and that it is possible to observe the chemical changes caused by the temperature rise due to laser irradiation. It has been observed a gradual organic material loss as the energy density goes up. These results are the first steps in testing the Er,Cr:YSGG laser efficacy as a cutting tool, a pivotal aspect of its consolidation in clinical procedures. (author)

  19. ATR-FTIR and UV-Vis Spectroscopic Studies of Aqueous U(IV)-oxalate Complexes under Mild Acidic Conditions

    International Nuclear Information System (INIS)

    The redox transformation process between U(VI) and U(IV) likely involves the participation of soluble or dissolved U(IV) species, such as U(IV)-hydroxo compounds and organic/inorganic ligand complexes. However, their role in the redox process has not been well documented, partly due to the ready oxidation of soluble U(IV) species, and partly due to the assumption that soluble or dissolved forms of U(IV) account for only a minor fraction of uranium in groundwater systems. In this study, a bidentate chelate ligand, oxalate (Ox) was selected to examine the complexation behaviors of U(IV) and ultimately its impact on the U(IV) solubility in mildly acidic solutions. Although some early studies reported that oxalate and pyrophosphate, i. e., multivalent anions, can form soluble U(IV) complexes, the related thermodynamic data and evidences for chemical speciation are very scarce. In our previous work, the U(IV)-Ox 1:1 complex was identified by monitoring the gradual transition of the characteristic absorption spectrum of U(OH)3+ to that of UOx2+ upon the addition of oxalate at pH 1.6.2.0. This work aims to further provide spectroscopic evidence for the formation of multi-ligand complexes, i. e., U(Ox)n4-2n (n ≥ 2) at pH 2-5 using attenuated total reflectance (ATR)- FTIR spectroscopy and UV-Vis absorption spectroscopy. The solid phase of U(IV)-Ox complex system was also characterized through an XRD analysis. Analysis of the FTIR spectra is found to be useful to determine the complexation stoichiometry and to obtain the structural information of the complexes. The outcome of the spectroscopic analysis for the multi-ligand complexation equilibria will be discussed in detail

  20. XPS, SIMS and FTIR-ATR characterization of boronized graphite from the thermonuclear plasma device RFX-mod

    Science.gov (United States)

    Ghezzi, F.; Laguardia, L.; Caniello, R.; Canton, A.; Dal Bello, S.; Rais, B.; Anderle, M.

    2015-11-01

    In this paper the characterization of a thin (tens of nanometers) boron layer on fine grain polycrystalline graphite substrate is presented. The boron film is used as conditioning technique for the full graphite wall of the Reversed Field eXperiment-modified (RFX-mod) experiment, a device for the magnetic confinement of plasmas of thermonuclear interest. Aim of the present analysis is to enlighten the chemical structure of the film, the trapping mechanism that makes it a getter for oxygen and hydrogen and the reason of its loss of effectiveness after exposure to about 100 s of hydrogen plasma. X-ray Photoelectron Spectroscopy (XPS), Secondary Ions Mass Spectrometry (SIMS) and Fourier Transform Infra Red spectroscopy in combination with the Attenuated Total Reflectance (FTIR-ATR) were used to obtain the structure and the chemical composition of graphitic samples as coated or coated and subsequently exposed to hydrogen plasma after boron deposition. The boron layers on the only coated samples were found to be amorphous hydrogenated boron carbide plus a variety of bonds like B-B, B-H, B-O, B-OH, C-C, C-H, C-O, C-OH. Both the thickness and the homogeneity of the layers were found to depend on the distance of the sample from the anode during the deposition. The samples contained oxygen along the layer thickness, at level of 5%, bound to boron. The gettering action of the boron is therefore already active during the deposition itself. The exposure to plasma caused erosion of the boron film and higher content of H and O bound to boron throughout the whole thickness. The interaction of the B layer with plasma is therefore a bulk phenomenon.

  1. Radiation Induced Aging Effects in Polymeric Cable Insulators at CERN. Compilation of the DSC and ATR-FTIR data on irradiated CERN cables.

    CERN Document Server

    Sorin, I

    2009-01-01

    This second part of the Report on Radiation Induced Aging Effects in Polymeric Cable Insulators at CERN [1] summarizes in a tabulated form all the experimental DSC results obtained in this work, concerning the life-time evaluation of the selected CERN cables irradiated in different conditions. Several examples of DSC curves and ATR-FTIR spectra were included to support the future polymeric materials analysis. Information on the experimental conditions, the instruments, the basic concept of life-time evaluation using the DSC data, as well as the examples of data processing and interpretation are presented and discussed in reference [1].

  2. Xenopus Cds1 Is Regulated by DNA-Dependent Protein Kinase and ATR during the Cell Cycle Checkpoint Response to Double-Stranded DNA Ends

    OpenAIRE

    McSherry, Troy D.; Mueller, Paul R.

    2004-01-01

    The checkpoint kinase Cds1 (Chk2) plays a key role in cell cycle checkpoint responses with functions in cell cycle arrest, DNA repair, and induction of apoptosis. Proper regulation of Cds1 is essential for appropriate cellular responses to checkpoint-inducing insults. While the kinase ATM has been shown to be important in the regulation of human Cds1 (hCds1), here we report that the kinases ATR and DNA-dependent protein kinase (DNA-PK) play more significant roles in the regulation of Xenopus ...

  3. Fuentes de variabilidad en el diagnóstico de gastritis atrófica multifocal asociada con la infección por Helicobacter pylori

    OpenAIRE

    Luis Eduardo Bravo; Juan Carlos Bravo; José Luis Realpe

    2008-01-01

    Introducción: El mapeo de las diferentes regiones del estómago y el número de fragmentos de mucosa gástrica disponibles para evaluación histopatológica son fuentes importantes de variación en el momento de clasificar y hacer la gradación de la gastritis crónica. Objetivos: Estimar la sensibilidad del número de fragmentos de mucosa gástrica necesarios para establecer los diagnósticos de gastritis atrófica con metaplasia intestinal (MI), displasia y estado de infección por Helicobacter pylori. ...

  4. Kinetic and Conformational Insights of Protein Adsorption onto Montmorillonite Revealed Using in Situ ATR-FTIR/2D-COS.

    Science.gov (United States)

    Schmidt, Michael P; Martínez, Carmen Enid

    2016-08-01

    Protein adsorption onto clay minerals is a process with wide-ranging impacts on the environmental cycling of nutrients and contaminants. This process is influenced by kinetic and conformational factors that are often challenging to probe in situ. This study represents an in situ attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopic investigation of the adsorption of a model protein (bovine serum albumin (BSA)) onto a clay mineral (montmorillonite) at four concentrations (1.50, 3.75, 7.50, and 15.0 μM) under environmentally relevant conditions. At all concentrations probed, FTIR spectra show that BSA readily adsorbs onto montmorillonite. Adsorption kinetics follow an Elovich model, suggesting that primary limitations on adsorption rates are surface-related heterogeneous energetic restrictions associated with protein rearrangement and lateral protein-protein interaction. BSA adsorption onto montmorillonite fits the Langmuir model, yielding K = 5.97 × 10(5) M(-1). Deconvolution and curve fitting of the amide I band at the end of the adsorption process (∼120 min) shows a large extent of BSA unfolding upon adsorption at 1.50 μM, with extended chains and turns increasing at the expense of α-helices. At higher concentrations/surface coverages, BSA unfolding is less pronounced and a more compact structure is assumed. Two-dimensional correlation spectroscopic (2D-COS) analysis reveals three different pathways corresponding to adsorbed conformations. At 1.50 μM, adsorption increases extended chains, followed by a loss in α-helices and a subsequent increase in turns. At 3.75 μM, extended chains decrease and then aggregated strands increase and side chains decrease, followed by a decrease in turns. With 7.50 and 15.0 μM BSA, the loss of side-chain vibrations is followed by an increase in aggregated strands and a subsequent decrease in turns and extended chains. Overall, the BSA concentration and resultant surface coverage have a profound

  5. Fluorescence, CD, attenuated total reflectance (ATR) FTIR, and sup 13 C NMR characterization of the structure and dynamics of synthetic melittin and melittin analogues in lipid environments

    Energy Technology Data Exchange (ETDEWEB)

    Weaver, A.J.; Prendergast, F.G. (Mayo Foundation, Rochester, MN (United States)); Kemple, M.D. (Indiana Univ.-Purdue Univ., Indianapolis (United States)); Brauner, J.W.; Mendelsohn, R. (Rutgers, The State Univ. of New Jersey, Newark (United States))

    1992-02-11

    The structure and dynamics of synthetic melittin (MLT) and MLT analogues bound to monomyristoylphosphatidylcholine micelles, dimyristoylphosphatidylcholine vesicles, and diacylphosphatidylcholine films have been investigated by fluorescence, CD, attenuated total reflectance (ATR) FTIR, and {sup 13}C NMR spectroscopy. All of these methods provide information about peptide secondary structure and/or about the environment of the single tryptophan side chain in these lipid environments. ATR-FTIR data provide additional information about the orientation of helical peptide segments with respect to the bilayer plane. Steady-state fluorescence anisotropy, fluorescence lifetime, and {sup 13}C NMR relaxation data are used in concert to provide quantitative information about the dynamics of a single {sup 13}C{alpha}-labeled glycine incorporated into each of the MLT peptides at position 12. The cumulative structural and dynamic data are consistent with a model wherein the N-terminal {alpha}-helical segment of these peptides is oriented perpendicular to the bilayer plane. Correlation times for the lysolipid-peptide complexes provide evidence for binding of a single peptide monomer per micelle. A model for the membranolytic action of MLT and MLT-like peptides is proposed.

  6. Detection and quantification of soymilk in cow-buffalo milk using Attenuated Total Reflectance Fourier Transform Infrared spectroscopy (ATR-FTIR).

    Science.gov (United States)

    Jaiswal, Pranita; Jha, Shyam Narayan; Borah, Anjan; Gautam, Anuj; Grewal, Manpreet Kaur; Jindal, Gaurav

    2015-02-01

    Milk consumption is steadily increasing, especially in India and China, due to rising income. To bridge the gap between supply and demand, unscrupulous milk vendors add milk-like products from vegetable sources (soymilk) to milk without declaration. A rapid detection technique is required to enforce the safety norms of food regulatory authorities. Fourier Transform Infrared (FTIR) spectroscopy has demonstrated potential as a rapid quality monitoring method and was therefore explored for detection of soymilk in milk. In the present work, spectra of milk, soymilk (SM), and milk adulterated with known quantity of SM were acquired in the wave number range of 4000-500cm(-1) using Attenuated Total Reflectance (ATR)-FTIR. The acquired spectra revealed differences amongst milk, SM and adulterated milk (AM) samples in the wave number range of 1680-1058cm(-1). This region encompasses the absorption frequency of amide-I, amide-II, amide-III, beta-sheet protein, α-tocopherol and Soybean Kunitz Trypsin Inhibitor. Principal component analysis (PCA) showed clustering of samples based on SM concentration at 5% level of significance and thus SM could be detected in milk using ATR-FTIR. The SM was best predicted in the range of 1472-1241cm(-1) using multiple linear regression with coefficient of determination (R(2)) of 0.99 and 0.92 for calibration and validation, respectively. PMID:25172681

  7. Sensing cocaine in saliva with attenuated total reflection infrared (ATR-IR) spectroscopy combined with a one-step extraction method

    Science.gov (United States)

    Hans, Kerstin M.-C.; Gianella, Michele; Sigrist, Markus W.

    2012-03-01

    On-site drug tests have gained importance, e.g., for protecting the society from impaired drivers. Since today's drug tests are majorly only positive/negative, there is a great need for a reliable, portable and preferentially quantitative drug test. In the project IrSens we aim to bridge this gap with the development of an optical sensor platform based on infrared spectroscopy and focus on cocaine detection in saliva. We combine a one-step extraction method, a sample drying technique and infrared attenuated total reflection (ATR) spectroscopy. As a first step we have developed an extraction technique that allows us to extract cocaine from saliva to an almost infrared-transparent solvent and to record ATR spectra with a commercially available Fourier Transform-infrared spectrometer. To the best of our knowledge this is the first time that such a simple and easy-to-use one-step extraction method is used to transfer cocaine from saliva into an organic solvent and detect it quantitatively. With this new method we are able to reach a current limit of detection around 10 μg/ml. This new extraction method could also be applied to waste water monitoring and controlling caffeine content in beverages.

  8. Kaposi sarcoma herpes virus latency associated nuclear antigen protein release the G2/M cell cycle blocks by modulating ATM/ATR mediated checkpoint pathway.

    Directory of Open Access Journals (Sweden)

    Amit Kumar

    Full Text Available The Kaposi's sarcoma-associated herpesvirus infects the human population and maintains latency stage of viral life cycle in a variety of cell types including cells of epithelial, mesenchymal and endothelial origin. The establishment of latent infection by KSHV requires the expression of an unique repertoire of genes among which latency associated nuclear antigen (LANA plays a critical role in the replication of the viral genome. LANA regulates the transcription of a number of viral and cellular genes essential for the survival of the virus in the host cell. The present study demonstrates the disruption of the host G2/M cell cycle checkpoint regulation as an associated function of LANA. DNA profile of LANA expressing human B-cells demonstrated the ability of this nuclear antigen in relieving the drug (Nocodazole induced G2/M checkpoint arrest. Caffeine suppressed nocodazole induced G2/M arrest indicating involvement of the ATM/ATR. Notably, we have also shown the direct interaction of LANA with Chk2, the ATM/ATR signalling effector and is responsible for the release of the G2/M cell cycle block.

  9. ATR-SEIRAS study of CO adsorption and oxidation on Rh modified Au(111-25 nm) film electrodes in 0.1 M H2SO4

    International Nuclear Information System (INIS)

    Rh modified Au(111-25 nm) electrodes, prepared by electron beam evaporation and galvanostatic deposition, were employed to study adsorption and electro-oxidation of CO on Rh in 0.1 M sulfuric acid solution by in situ attenuated total reflection surface enhanced infrared absorption spectroscopy (ATR-SEIRAS). The results of ATR-SEIRAS experiments were compared with those obtained by infrared reflection absorption spectroscopy on three low-index Rh single crystal surfaces. The Rh film deposited on Au(111-25 nm) electrode consists of 3D clusters forming a highly stepped [n(111) × (111)]-like surface with narrow (111) terraces. When CO was dosed at the hydrogen adsorption potential region, CO adsorbed in both atop (COL) and bridge (COB) configurations, as well as coadsorbed water species, were detected on the Rh film electrode. A partial interconversion of spectroscopic bands due to the CO displacement from bridge to atop sites was found during the anodic potential scan, revealing that there is a potential-dependent preference of CO adsorption sites on Rh surfaces. Our data indicate that CO oxidation on Rh electrode surface in acidic media involves coadsorbed water and follows the nucleation and growth model of a Langmuir-Hinshelwood type reaction

  10. Observations of surface-mediated reduction of Pu(VI) to Pu(IV) on hematite nanoparticles by ATR FT-IR

    International Nuclear Information System (INIS)

    Previous studies have shown that mineral surfaces may facilitate the reduction of plutonium though the mechanisms of the reduction are still unknown. The objective of this study is to use batch sorption and attenuated total reflectance Fourier transform infrared spectroscopy experiments to observe the surface-mediated reduction of plutonium on hematite nanoparticles. These techniques allow for in situ measurement of reduction of plutonium with time and may lead to a better understanding of the mechanisms of surface mediated reduction of plutonium. For the first time, ATR FT-IR peaks for Pu(VI) sorbed to hematite are measured at ∝ 916 cm-1, respectively. The decrease in peak intensity with time provides a real-time, direct measurement of Pu(VI) reduction on the hematite surface. In this work pseudo first order rate constants estimated at the high loadings (22 mgPu/ghematite, 1.34 x 10-6 MPu/m2) for ATR FT-IR are approximately 10 x slower than at trace concentrations based on previous work. It is proposed that the reduced rate constant at higher Pu loadings occurs after the reduction capacity due to trace Fe(II) has been exhausted and is dependent on the oxidation of water and possibly electron shuttling based on the semiconducting nature of hematite. Therefore, the reduction rate at higher loadings is possibly due to the thermodynamic favorability of Pu(IV)-hydroxide complexes.

  11. ATR-FTIR Based Pre and Post Formulation Compatibility Studies for the Design of Niosomal Drug Delivery System Containing Nonionic Amphiphiles and Chondroprotective Drug

    International Nuclear Information System (INIS)

    Pharmaceutical compatibility studies are considered as the most important and first screening stage during development of pharmaceutical drug product. Attenuated total reflectance/fourier transform infrared (ATR-FTIR) is one of the techniques currently available to pharmaceutical scientists for investigating the compatibilities between active drug and inactive pharmaceutical ingredients. The present study was designed to assess the interaction among different niosomes forming components i.e nonionic amphiphiles and chondroprotective/antiinflamatory drug Diacerein by ATR-FTIR method. Physical mixtures and niosomes were prepared by physical mixing and thin film hydration method, respectively. The individual niosomal components, physical mixtures as well as niosomal formulations were analyzed. The spectra of Diacerein showed characteristic peaks at 3300 cm/sup -1/(-COOH) and 760 cm/sup -1/(msubstituted benzene), Span 60 at 2916 cm/sup -1/(-OH), Span 80 at 1740 cm/sup -1/(5- membered ring), Span 85 at 1643 cm/sup -1/(ketone with 5-membered ring), Tween 20 at 1734 cm/sup 1/ (5-membered ring) and Tween 80 at 3488 cm/sup -1/(-OH). The characteristic peaks of Diacerein were present in niosomal formulations with slight shift at 3355-3379 cm/sup -1/(-COOH) and 760-770 cm/sup -1/(m-substituted benzene). This work suggested no significant interaction in characteristic peaks of Diacerein after combining with nonionic surfactants as physical mixtures and niosomal formulations which proposed potential for niosomes to encapsulate diacerein in their micro vicinity. (author)

  12. Observations of surface-mediated reduction of Pu(VI) to Pu(IV) on hematite nanoparticles by ATR FT-IR

    Energy Technology Data Exchange (ETDEWEB)

    Emerson, Hilary P. [Florida International Univ., Applied Research Center, Miami, FL (United States); Powell, Brian A. [Clemson Univ., Dept. of Enviromental Engineering and Earth Sciences, Anderson, SC (United States)

    2015-07-01

    Previous studies have shown that mineral surfaces may facilitate the reduction of plutonium though the mechanisms of the reduction are still unknown. The objective of this study is to use batch sorption and attenuated total reflectance Fourier transform infrared spectroscopy experiments to observe the surface-mediated reduction of plutonium on hematite nanoparticles. These techniques allow for in situ measurement of reduction of plutonium with time and may lead to a better understanding of the mechanisms of surface mediated reduction of plutonium. For the first time, ATR FT-IR peaks for Pu(VI) sorbed to hematite are measured at ∝ 916 cm{sup -1}, respectively. The decrease in peak intensity with time provides a real-time, direct measurement of Pu(VI) reduction on the hematite surface. In this work pseudo first order rate constants estimated at the high loadings (22 mg{sub Pu}/g{sub hematite}, 1.34 x 10{sup -6} M{sub Pu}/m{sup 2}) for ATR FT-IR are approximately 10 x slower than at trace concentrations based on previous work. It is proposed that the reduced rate constant at higher Pu loadings occurs after the reduction capacity due to trace Fe(II) has been exhausted and is dependent on the oxidation of water and possibly electron shuttling based on the semiconducting nature of hematite. Therefore, the reduction rate at higher loadings is possibly due to the thermodynamic favorability of Pu(IV)-hydroxide complexes.

  13. ATR-FTIR and XPS study on the structure of complexes formed upon the adsorption of simple organic acids on aluminum hydroxide

    Institute of Scientific and Technical Information of China (English)

    GUAN Xiao-hong; CHEN Guang-hao; SHANG Chii

    2007-01-01

    Information on the binding of organic ligands to metal (hydr)oxide surfaces is useful for understanding the adsorption behaviour of natural organic matter (NOM) on metal (hydr)oxide. In this study, benzoate and salicylate were employed as the model organic ligands and aluminum hydroxide as the metal hydroxide. The attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectra revealed that the ligands benzoate and salicylate do coordinate directly with the surface of hydrous aluminum hydroxide, thereby forming inner-sphere surface complexes. It is concluded that when the initial pH is acidic or neutral, monodentate and bridging complexes are to be formed between benzoate and aluminum hydroxide while bridging complexes predominate when the initial pH is alkalic. Monodentate and bridging complexes can be formed at pH 5 while precipitate and bridging complexes are formed at pH 7 when salicylate anions are adsorbed on aluminum hydroxide. The X-ray photoelectron (XP) spectra demonstrated the variation of C 1s binding energy in the salicyate and phenolic groups before and after adsorption. It implied that the benzoate ligands are adsorbed through the complexation between carboxylate moieties and the aluminum hydroxide surface, while both carboxylate group and phenolic group are involved in the complexation reaction when salicylate is adsorbed onto aluminum hydroxide. The information offered by the XPS confirmed the findings obtained with ATR-FTIR.

  14. A novel technique for the rapid determination of tributyl phosphate degradation from alkaline hydrolysis in aqueous and organic phases using FTIR-ATR and verification of this technique by gas chromatography

    International Nuclear Information System (INIS)

    This paper details a semi-quantitative method for determining tributyl phosphate (TBP) degradation from alkaline hydrolysis using FTIR-ATR accompanied by GC verification and it provides a method to extract TBP from aqueous media associated with its use in nuclear reprocessing. The amount of TBP determined by GC decreases from 95 to 36 % after approximately 4 1/2 h in the reaction. TBP present in the organic phase predicted by the FTIR-ATR technique shows that TBP decreases from 97 to 42 %. Up to 15 % of TBP and 40 % of DBP were extracted from the precipitate based on the extraction recoveries determined. (author)

  15. Tratamiento del maxilar posterior atrófico mediante técnica de reconstrucción tridimensional con elevación de seno y abordaje «en tunel»

    Directory of Open Access Journals (Sweden)

    Andrés Restoy

    2015-01-01

    Conclusiones: El tratamiento del sector posterior maxilar atrófico mediante reconstrucción tridimensional con autoinjerto óseo, elevación sinusal y abordaje por tunelización es una técnica que proporciona resultados predecibles y estables, permitiendo la rehabilitación con coronas sobre implantes dentales de dimensiones adecuadas.

  16. Non-apoptotic programmed cell death with paraptotic-like features in bleomycin-treated plant cells is suppressed by inhibition of ATM/ATR pathways or NtE2F overexpression

    Czech Academy of Sciences Publication Activity Database

    Smetana, O.; Široký, Jiří; Houlné, G.; Opatrný, Z.; Chabouté, M.-E.

    2012-01-01

    Roč. 63, č. 7 (2012), s. 2631-2644. ISSN 0022-0957 Institutional research plan: CEZ:AV0Z50040702 Keywords : ATM /ATR pathways * cell cycle * double-strand break response Subject RIV: BO - Biophysics Impact factor: 5.242, year: 2012

  17. Identification of natural dyes on laboratory-dyed wool and ancient wool, silk, and cotton fibers using attenuated total reflection (ATR) Fourier transform infrared (FT-IR) spectroscopy and Fourier transform Raman spectroscopy.

    Science.gov (United States)

    Bruni, Silvia; De Luca, Eleonora; Guglielmi, Vittoria; Pozzi, Federica

    2011-09-01

    Attenuated total reflection (ATR) infrared and Fourier transform (FT) Raman spectra were obtained from wool threads dyed in the laboratory with natural dyes used in antiquity, following a procedure similar to ancient methods for dyeing wool. The ATR spectra were primarily dominated by the signals of the wool, making it difficult to identify the dye on the fibers only by visual inspection of the infrared spectrum. However, the Raman spectra showed more significant characteristics attributable to the dyes as previously studied in the literature on modern synthetic dyes. A library-search method was thus applied to the second derivatives of both the ATR and Raman spectra to verify the possibility of identifying the dye. Two libraries were constructed, one consisting of the ATR spectra of undyed wool (raw, washed, and mordanted) and the transmission spectra of pure dyes and the other consisting of the Raman spectra of undyed wool and of pure dyes. Correlation and first-derivative correlation search algorithms were used. The results presented here suggest that the two types of spectroscopy are complementary in this kind of work, allowing the almost complete identification of historic dyes on wool. In fact, through the combined use of the two searches, most dyes were identified with a good index of similarity and within the first five hits. Only for annatto was identification totally impossible using either technique. Subsequently the same method was applied to wool, silk, and cotton threads taken from ancient Caucasian and Chinese textiles. PMID:21929856

  18. Application of Attenuated Total Reflectance-Fourier Transformed Infrared (ATR-FTIR) Spectroscopy To Determine the Chlorogenic Acid Isomer Profile and Antioxidant Capacity of Coffee Beans.

    Science.gov (United States)

    Liang, Ningjian; Lu, Xiaonan; Hu, Yaxi; Kitts, David D

    2016-01-27

    The chlorogenic acid isomer profile and antioxidant activity of both green and roasted coffee beans are reported herein using ATR-FTIR spectroscopy combined with chemometric analyses. High-performance liquid chromatography (HPLC) quantified different chlorogenic acid isomer contents for reference, whereas ORAC, ABTS, and DPPH were used to determine the antioxidant activity of the same coffee bean extracts. FTIR spectral data and reference data of 42 coffee bean samples were processed to build optimized PLSR models, and 18 samples were used for external validation of constructed PLSR models. In total, six PLSR models were constructed for six chlorogenic acid isomers to predict content, with three PLSR models constructed to forecast the free radical scavenging activities, obtained using different chemical assays. In conclusion, FTIR spectroscopy, coupled with PLSR, serves as a reliable, nondestructive, and rapid analytical method to quantify chlorogenic acids and to assess different free radical-scavenging capacities in coffee beans. PMID:26725502

  19. Study of Barley Grain Molecular Structure for Ruminants Using DRIFT, FTIR-ATR and Synchrotron Radiation Infrared Microspectroscopy (SR-IMS): A Review

    Science.gov (United States)

    Yu, Peiqiang

    2012-05-01

    Barley inherent structures are highly associated with nutrient utilization and availability in both humans and animals. Barley has different degradation kinetics compared with other cereal grains. It has a relatively higher degradation rate and extent, which often cause digestive disorder in the rumen. Therefore understanding barley inherent structure at cellular and molecular levels and processing-induced structure changes is important, because we can manipulate barley inherent structures and digestive behaviors. Several molecular spectroscopy techniques can be used to detect barley inherent structures at cellular and molecular levels. This article reviews several applications of the IR molecular spectral bioanalytical techniques - DRIFT, FT/IR-ATR and SR-IMS for barley chemistry, molecular structure and molecular nutrition research

  20. Study of Barley Grain Molecular Structure for Ruminants Using DRIFT, FTIR-ATR and Synchrotron Radiation Infrared Microspectroscopy (SR-IMS): A Review

    International Nuclear Information System (INIS)

    Barley inherent structures are highly associated with nutrient utilization and availability in both humans and animals. Barley has different degradation kinetics compared with other cereal grains. It has a relatively higher degradation rate and extent, which often cause digestive disorder in the rumen. Therefore understanding barley inherent structure at cellular and molecular levels and processing-induced structure changes is important, because we can manipulate barley inherent structures and digestive behaviors. Several molecular spectroscopy techniques can be used to detect barley inherent structures at cellular and molecular levels. This article reviews several applications of the IR molecular spectral bioanalytical techniques - DRIFT, FT/IR-ATR and SR-IMS for barley chemistry, molecular structure and molecular nutrition research

  1. Selective Alcohol Oxidation by a Copper TEMPO Catalyst: Mechanistic Insights by Simultaneously Coupled Operando EPR/UV-Vis/ATR-IR Spectroscopy.

    Science.gov (United States)

    Rabeah, Jabor; Bentrup, Ursula; Stößer, Reinhard; Brückner, Angelika

    2015-09-28

    The first coupled operando EPR/UV-Vis/ATR-IR spectroscopy setup for mechanistic studies of gas-liquid phase reactions is presented and exemplarily applied to the well-known copper/TEMPO-catalyzed (TEMPO=(2,2,6,6-tetramethylpiperidin-1-yl)oxyl) oxidation of benzyl alcohol. In contrast to previous proposals, no direct redox reaction between TEMPO and Cu(I) /Cu(II) has been detected. Instead, the role of TEMPO is postulated to be the stabilization of a (bpy)(NMI)Cu(II) -O2 (⋅-) -TEMPO (bpy=2,2'-bipyridine, NMI=N-methylimidazole) intermediate formed by electron transfer from Cu(I) to molecular O2 . PMID:26174141

  2. Fourier transform infrared-attenuated total reflectance (FTIR-ATR spectroscopy and chemometric techniques for the determination of adulteration in petrodiesel/biodiesel blends

    Directory of Open Access Journals (Sweden)

    Armando Guerrero Peña

    2014-06-01

    Full Text Available We propose an analytical method based on fourier transform infrared-attenuated total reflectance (FTIR-ATR spectroscopy to detect the adulteration of petrodiesel and petrodiesel/palm biodiesel blends with African crude palm oil. The infrared spectral fingerprints from the sample analysis were used to perform principal components analysis (PCA and to construct a prediction model using partial least squares (PLS regression. The PCA results separated the samples into three groups, allowing identification of those subjected to adulteration with palm oil. The obtained model shows a good predictive capacity for determining the concentration of palm oil in petrodiesel/biodiesel blends. Advantages of the proposed method include cost-effectiveness and speed; it is also environmentally friendly.

  3. ATR-FTIR spectroscopy reveals polycyclic aromatic hydrocarbon contamination despite relatively pristine site characteristics: Results of a field study in the Niger Delta.

    Science.gov (United States)

    Obinaju, Blessing E; Martin, Francis L

    2016-01-01

    Fourier-transform infrared (FTIR) spectroscopy is an emerging technique to detect biochemical alterations in biological tissues, particularly changes due to sub-lethal exposures to environmental contaminants. We have previously shown the potential of attenuated total reflection FTIR (ATR-FTIR) spectroscopy to detect real-time exposure to contaminants in sentinel organisms as well as the potential to relate spectral alterations to the presence of specific environmental agents. In this study based in the Niger Delta (Nigeria), changes occurring in fish tissues as a result of polycyclic aromatic hydrocarbon (PAH) exposure at contaminated sites are compared to the infrared (IR) spectra of the tissues obtained from a relatively pristine site. Multivariate analysis revealed that PAH contamination could be occurring at the pristine site, based on the IR spectra and significant (P<0.0001) differences between sites. The study provides evidence of the IR spectroscopy techniques' sensitivity and supports their potential application in environmental biomonitoring. PMID:26826366

  4. El cuento de la verdad "El cuento de la verdad "El cuento de atrás" y "El lápiz del carpintero"

    OpenAIRE

    Bazán Rodríguez, Óscar

    2012-01-01

    Uno de los puntos claves que se ha venido trabajando en la literatura española contemporánea es el tratamiento de la memoria, y dentro de este tema, cómo se afronta un concepto tan inasible como el del “la verdad” desde un punto de vista narrativo. En este artículo nos aproximamos a la visión de “la verdad” a través de dos de las novelas más importantes que tocan la Guerra Civil española: “El cuarto de atrás”, de Carmen Martín Gaite; y “El lápiz del carpintero”, de Manuel Rivas...

  5. FTIR-ATR study of the influence of the pyrimidine analog of fluphenazine on the chain-melting phase transition of sphingomyelin membranes

    Science.gov (United States)

    Kuć, Marta; Cieślik-Boczula, Katarzyna; Świątek, Piotr; Jaszczyszyn, Agata; Gąsiorowski, Kazimierz; Malinka, Wiesław

    2015-09-01

    The membrane perturbing potency of the highly effective anti-multidrug resistance (MDR) pyrimidine analog of fluphenazine (FPh-prm), has been studied using attenuated total reflectance Fourier-transfer infrared spectroscopy (FTIR-ATR). The temperature- and FPh-prm-dose-dependent evolutions of the infrared spectra of FPh-prm/sphingomyelin (SM) mixtures were analyzed using principal component analysis (PCA). It has been postulated that the distinct anti-MDR activity of FPh-prm could be related to its ability to affect the modification of SM membranes. A reduction in the temperature of the chain-melting phase transition was observed in FPh-prm-mixed SM membranes together with the loosing of the phase transition cooperativity. Increasing the temperature led to the trans to gauche isomerization of FPh-prm-rich lipid membranes, which resulted in the gradual release of FPh-prm from the lipid membrane to the water phase.

  6. Técnicas FT-IR (PAS, UATR e Objetiva ATR Aplicadas à Caracterização de EPDM Modificada com Plasma

    Directory of Open Access Journals (Sweden)

    Renata Patrícia dos Santos

    2014-06-01

    Full Text Available Técnicas FT-IR (UATR, PAS e MIC, com objetiva ATR foram escolhidas para a caracterização da superfície da borracha de EPDM vulcanizada, após tratamento em plasma de Ar/O2 e N2/H2/Ar gerado em micro-ondas. Após tratamento, grupos oxigenados foram detectados por UATR e MIC/FT-IR, com objetiva ATR para as duas misturas gasosas, e possíveis grupos nitrogenados foram inseridos na superfície das amostras tratadas com plasma de N2/H2/Ar. A análise MIC/FT-IR sugeriu a formação de grupos em uma camada mais externa, para as amostras tratadas com plasma de N2/H2/Ar, sendo possível observar a redução na intensidade das bandas da absorção do CH2 e CH3, o que pode estar relacionado ao fato de o nitrogênio ser um gás menos permeável que o oxigênio. Diferentes velocidades, 0,05 cm.s-1 e 0,2 cm.s-1, foram utilizadas na análise PAS para avaliar a superfície após tratamento, e apenas para a velocidade 0,05 cm.s-1 com plasma de Ar/O2 alterações espectroscópicas foram detectadas. A redução na medida de ângulo de contato e o aumento na resistência ao descascamento da colagem indicaram melhoras nas propriedades adesivas da superfície. Falhas de adesão foram observadas entre a interface do filme de adesivo de PU e da borracha de EPDM, e confirmados por UATR/FT-IR.

  7. Model Persediaan Terintegrasi Berdasarkan Perbandingan Biaya

    OpenAIRE

    Sibarani, Johannes Andre

    2011-01-01

    Every company must be has the policy in managing its inventory, so that production processes can be run well. Two mathematical model of inventories are analised. The aim of these models are minimizing the total cost of inventories on a company and its distributor. The first mathematical model is IDQ (Identical Delivery Quantity) model, the amount of delivery to distributor is identically for every replenishment. The second one is DWP (Delivery What is Produced) model, the amoun...

  8. Penciptaan Naskah Drama Narcissus Berdasarkan Mitologi Yunani

    Directory of Open Access Journals (Sweden)

    Titis Rahayuningtiar

    2013-11-01

    Full Text Available Naskah drama Narcissus adalah sebuah naskah drama dengan genre klasik yang mengusung irama tragis. Narcissus adalah sebuah tokoh yang berasal dari cerita mitologi Yunani. Narcissus merupakan seorang pemuda sombong yang sangat mengagungkan keindahan yang ada dalam dirinya. Hingga suatu hari Narcissus dikutuk untuk jatuh cinta pada bayangannya sendiri. Penciptaan naskah drama Narcissus bertujuan untuk mengisi kelangkaan naskah drama yang sumber idenya berasal dari fenomena narsis di masyarakat dan konsep irama tragis dalam mitologi Yunani. Metode penciptaan mengusung sebuah metode kreatif yang terdiri dari tahap eksplorasi, pembentukan dan improvisasi. Hasil  penciptaan naskah ini adalah sebuah naskah bergenre klasik yang memiliki pesan moral bahwasanya seseorang yang menganggap dirinya sempurna akan memberi akibat buruk untuk dirinya sendiri. Kesempurnaan hanyalah milik Tuhan.Kata kunci: Narcissus, Yunani, mitologi.ABSTRACTThe Creation of the Drama Script of Narcissus Based on the Greek Mythology. The script of Narcissus drama is a script of drama with a classical genre which carries the tragic rhythm on it. Narcissus is a character in the story of the Greek Mythology. He is an arrogant young man who really likes to glorify himself on the beauty of what he has. Unfortunatelly, one day he was cursed to fall in love with his own reflection. The creation of drama script of Narcissus is aimed to fill the scarcity of drama scripts in which the basic sources of idea come from narcissistic phenomena in a society and the concept of the tragic rhythm in the Greek mythology. The method of creation brings a creative method comprising the steps of exploration, creation, and improvisation. The result of this script creation is a classical genre script which has a moral message in which a person who considers himself perfectly will give a bad impact to himself. Nevertheles, perfection belongs to God only.Key words: Narcissius, Greek , mythology

  9. KEKERABATAN Hoya (ASCLEPIADACEAE SUMATERA BERDASARKAN KARAKTER MORFOLOGI

    Directory of Open Access Journals (Sweden)

    Sri Rahayu

    2011-01-01

    Full Text Available Morphological relationships analysis of Hoya species from Sumatra was carried out. The study was taken both from the living collections at Bogor Botanic Garden and the herbarium specimens at Herbarium Bogoriense. There are 25 Hoya species in Sumatra resulted from the total of 129 samples number. Cluster analysis was run by Clique of Phylip software based on morphological diagnostic characters. Five paraphiletic groups were resulted from the phylogenic analyses. The groups constructed from this analysis were tending to be identical with the Schlecter's section classification.

  10. Garis dan Titik Berdasarkan Riset Visual

    Directory of Open Access Journals (Sweden)

    Devi Kurniawati Homan

    2015-06-01

    Full Text Available A design may not be created instantly, without going through a process of creation. At the beginning it all starts from nothing, blank. It requires a visual research to make a visual communication. Without a visual research, the design will not have a strong meaning to be communicated. When an idea is created, the next step is to generate the idea to become a design. The first thing a designer to do is drawing a line. Line is one of the design basic elements. In the journey to make a good design, a designer requires a visual record to assist her/him in remembering what is important. A visual record contains not only visual things seen by eyes, but also the perceived things. What is felt at the moment is important because it is easier to forget than visual memory. Sense is an important element in design. A good work will easily be communicated not only by visuals but also from senses. The study was conducted as an insight into the process of making a visual record of nirmana using visual recording method in the exploration of dots and dashes. This method was used to sharpen the sensitivity of students to dots and lines. Initially, the students visited a traditional market to do the visual research. After that, they created a visual record in the form of the composition of dots and lines in nirmana to remember the taste, smell, and visual experiences.

  11. Semantik Suksesi Sistem Informasi Berdasarkan Populasi Teks

    OpenAIRE

    Elfida, Maria

    2015-01-01

    The information system success relates to the measurement of user satisfaction and information system actuators. In other words, the existence of information systems are always related to organizations or groups of people that involve information technology for processing and presenting data in decision making. Therefore, the existence of an information system deal with information technology changes, changes in demanding service to users of information systems. Especially the ...

  12. Alternatif Pengembangan Pendidikan Berdasarkan Nilai Kebutuhan Khusus

    Directory of Open Access Journals (Sweden)

    Silverius Constantino Johanes Maria Lake

    2015-06-01

    Full Text Available The Community College is a kind of higher education. It focuses on diploma degree (the Two Year College. The objectives of Community College are to educate and to train students for getting working skills for jobs. The Community College has competencies that are suitable with the working area and the local needs. To run the Community College goodly and truly, values is needed. Those values influence the mission of Community College. The question was why Indonesian Higher Education accepts the Community College as a model of higher education. The problem was related to some models of higher education that do not fulfill the demands of companies yet. Therefore the Community College becomes a choice to answer the demands of industries and etrepreneurship. The right references to learn about Community College are American Community Colleges such as Highline Community College (Seattle, WA and Kapiolani Community Collere (Honolulu, HI. Each of those Community Colleges has the best program for example Highline Community College in Business Management, then Kapiolani Community College in Culinary Arts. This article used descriptive and argumentative method to show the importance of Commuity College in Indonesia.

  13. Garis dan Titik Berdasarkan Riset Visual

    OpenAIRE

    Devi Kurniawati Homan

    2015-01-01

    A design may not be created instantly, without going through a process of creation. At the beginning it all starts from nothing, blank. It requires a visual research to make a visual communication. Without a visual research, the design will not have a strong meaning to be communicated. When an idea is created, the next step is to generate the idea to become a design. The first thing a designer to do is drawing a line. Line is one of the design basic elements. In the journey to make a good des...

  14. Alternatif Pengembangan Pendidikan Berdasarkan Nilai Kebutuhan Khusus

    OpenAIRE

    Silverius Constantino Johanes Maria Lake

    2015-01-01

    The Community College is a kind of higher education. It focuses on diploma degree (the Two Year College). The objectives of Community College are to educate and to train students for getting working skills for jobs. The Community College has competencies that are suitable with the working area and the local needs. To run the Community College goodly and truly, values is needed. Those values influence the mission of Community College. The question was why Indonesian Higher Education accepts th...

  15. PERUMUSAN STRATEGI PERUSAHAAN BERDASARKAN COMPETITIVE ADVANTAGE

    Directory of Open Access Journals (Sweden)

    Endah Utami

    2012-12-01

    Full Text Available Perusahaan Tenun Ikat Lestari Indah adalah perusahaan pembuatan kain dengan alat tenun bukan mesin. Dalam menjalankan bisnisnya, perusahaan menghadapi berbagai kendala, diantaranya daya beli masyarakat menurun akibat situasi perekonomian yang tidak menentu serta persaingan harga yang tidak sehat antar pengrajin. Tujuan penelitian ini adalah untuk merumuskan strategi perusahaan sesuai dengan kondisi internal dan eksternal perusahaan. Metode yang digunakan dalam penelitian ini adalah analisis SWOT, I-E (Internal-External, dan QSPM (Quantitative Strategy Planning Matrix. Hasil penelitian menunjukkan posisi bisnis perusahaan berada pada posisi pertumbuhan, sehingga strategi yang dirumuskan adalah menghindari kehilangan profit dan penjualan. Dari hasil analisis QSPM (Quantitative Strategy Planning Matrix diketahui strategi yang terpilih untuk strategi jangka pendek adalah menjalin hubungan baik dengan konsumen tetap , strategi jangka pendek-menengah adalah menjalin kerjasama dengan biro-biro perjalanan wisata, strategi jangka menengah adalah menetapkan tingkatan harga sesuai kualitas dan desain, dan strategi jangka panjang adalah memperluas jaringan pemasaran di dalam dan luar negeri.

  16. PENATAAN RUANG LAUT BERDASARKAN INTEGRATED COASTAL MANAGEMENT

    Directory of Open Access Journals (Sweden)

    Dina Sunyowati

    2008-10-01

    Full Text Available The planning of coastal spatial arrangement must be put in the valid spatial planning system. Law Number 26 of 2007 on Spatial Planning and it is in fact related with land spatial planning, although that ocean and air spatial management will be arranged in separate law. The legal for coastal zone management is determined by using the principles of integrated coastal management by focusing on area or zone authority system. The integrated of coastal zones management regulations should be followed by the planning of coastal spatial arrange­ment. Therefore, certain synchronization at coastal zones governance is very important issue since by integrating and coordinating other related regulations and therefore conflict of norm can be minimized in the spatial planning coastal zone.

  17. Faktor Risiko Penyakit Ginjal Kronik Berdasarkan Analisis Cross-sectional Data Awal Studi Kohort Penyakit Tidak Menular Penduduk Usia 25-65 Tahun di Kelurahan Kebon Kalapa, Kota Bogor Tahun 2011

    Directory of Open Access Journals (Sweden)

    Eva Sulistiowati

    2015-11-01

    Full Text Available AbstractGlomerular Filtration Rate (GFR is associated with renal function and used to diagnose Chronic Kidney Disease (CKD. CKD is considered a serious worldwide public health problem, and the prevalence is increasing dramatically. The aim of the analisis is to explore of the factors associated with estimated Glomerular Filtration Rate (eGFR. This analysis used subset baseline data Cohort Study Non-Communicable Diseases (NCD 2011 with a cross-sectional design. CKD was defined as those withan estimated glomerular filtration rate (eGFR <60 mL/min/1.73 m2. We analyzed of 1932 subjects (820 males and 1112 females aged 25-65 years old. GFR was estimated by using calibrated serum creatinine level with a formula CKD-epi, devided into ≥60 mL/min/1.73 m2 and <60 mL/min/1.73 m2. Subject with e-GFR <60 mL/min/1.73 m2 was 2,3%, and increased remarkably with age. Multivariate logistic regression analysis demonstrated that age of 49-65 years (OR=13.57; 95% CI: 4.73-38.97,economic status quintile 1 (OR=4.44; 95% CI: 1.14-17.39, hipertension (OR=3.71;95% CI: 1.82-7.59, male gender (OR=2.97; 95% CI: 1.49-5.92, diabetes mellitus (OR=2.54; 95% CI=1.24-5.20, obesity(OR=2.51; 95% CI: 1.20-5.25, were significant factors that were independently associated with CKD.Keywords : risk factors; glomerular filtration rate; CKDAbstrakLaju filtrasi glomerulus (LFG berhubungan dengan kondisi fungsi ginjal dan digunakan sebagai penentu diagnosis Penyakit Ginjal Kronik (PGK. PGK merupakan masalah kesehatan yang serius dan prevalensinya meningkat secara drastis. Tujuan analisis ini untuk mengetahui faktor yang berhubungan dengan PGK. Data diambil dari subset data Studi Kohor Penyakit Tidak Menular (PTM di Kota Bogor Tahun 2011, menggunakan disain analisis potong lintang. Subjek yang dianalis berjumlah 1932 orang(1112 perempuan dan 820 laki-laki berumur 25-65 tahun. LFG diklasifikasikan menurut estimasi LFG (e-LFG berdasarkan kriteria CKD-epi, dengan kategori ≥60 mL/min/1,73 m2

  18. Observation of chemical modification of Asian Dust particles during long-range transport by the combined use of quantitative ED-EPMA and ATR-FT-IR imaging

    Directory of Open Access Journals (Sweden)

    Young-Chul Song

    2012-10-01

    Full Text Available In our previous works, it was demonstrated that the combined use of quantitative energy-dispersive electron probe X-ray microanalysis (ED-EPMA, which is also known as low-Z particle EPMA, and attenuated total reflectance FT-IR (ATR-FT-IR imaging has great potential for a detailed characterization of individual aerosol particles. In this study, individual Asian Dust particles collected during an Asian Dust storm event on 11 November 2011 in Korea were characterized by the combined use of low-Z particle EPMA and ATR-FT-IR imaging. The combined use of the two single-particle analytical techniques on the same individual particles showed that Asian Dust particles had experienced extensive chemical modification during long-range transport. Overall, 109 individual particles were classified into four particle types based on their morphology, elemental concentrations, and molecular species and/or functional groups of individual particles available from the two analytical techniques: Ca-containing (38%; NaNO3-containing (30%; silicate (22%; and miscellaneous particles (10%. Among the 41 Ca-containing particles, 10, 8, and 14 particles contained nitrate, sulfate, and both, respectively, whereas only two particles contained unreacted CaCO3. Airborne amorphous calcium carbonate (ACC particles were observed in this Asian Dust sample for the first time, where their IR peaks for the insufficient symmetric environment of CO32− ions of ACC were clearly differentiated from those of crystalline CaCO3. This paper also reports the field observations of CaCl2 particles converted from CaCO3 for the Asian Dust sample collected in the planetary boundary layer. Thirty three particles contained NaNO3, which are the reaction products of sea-salt and NOx/HNO3, whereas no genuine sea-salt particles were encountered, indicating that sea-salt particles

  19. Study of the interface solid/solutions containing PEO-PPO block copolymers and asphaltenes by FTIR/ATR; Estudo de solucoes de copolimeros em bloco de PEO-PPO contendo asfaltenos por FTIR/DTA

    Energy Technology Data Exchange (ETDEWEB)

    Aguiar, Janaina I.S.; Neto, Jessica S.G.; Mansur, Claudia R.E. [Universidade Federal do Rio de Janeiro, Instituto de Macromoleculas, Laboratorio de Macromoleculas e Coloides na Industria de Petroleo, Rio de Janeiro, RJ (Brazil)], E-mails: janaina_333@hotmail.com, kinha_dac_dm@hotmail.com; celias@ima.ufrj.br

    2011-07-01

    The formation of water/oil emulsions can cause problems in various stages of production, processing and refining of petroleum. In this study, the technique of Fourier transform infrared spectroscopy (FTIR) using the method of attenuated total reflectance (ATR) was applied to study the solid-solutions of block copolymers based on poly(ethylene oxide)-poly(propylene oxide) (PEO-PPO) interface and its interaction in this interface with asphaltenic fractions of petroleum. The solid is the crystal of the ATR. Initially, we determined the critical micelle concentration values of the copolymers, which were consistent those obtained by a tensiometer. Bottle Test was also performed to correlate the efficiency of PEO-PPO copolymers in the breaking of water/oil emulsions with its adsorption at the interfaces solutions. (author)

  20. Mangrove dolabrane-type of diterpenes tagalsins suppresses tumor growth via ROS-mediated apoptosis and ATM/ATR-Chk1/Chk2-regulated cell cycle arrest.

    Science.gov (United States)

    Neumann, Jennifer; Yang, Yi; Köhler, Rebecca; Giaisi, Marco; Witzens-Harig, Mathias; Liu, Dong; Krammer, Peter H; Lin, Wenhan; Li-Weber, Min

    2015-12-01

    Natural compounds are an important source for drug development. With an increasing cancer rate worldwide there is an urgent quest for new anti-cancer drugs. In this study, we show that a group of dolabrane-type of diterpenes, collectively named tagalsins, isolated from the Chinese mangrove genus Ceriops has potent cytotoxicity on a panel of hematologic cancer cells. Investigation of the molecular mechanisms by which tagalsins kill malignant cells revealed that it induces a ROS-mediated damage of DNA. This event leads to apoptosis induction and blockage of cell cycle progression at S-G2 phase via activation of the ATM/ATR-Chk1/Chk2 check point pathway. We further show that tagalsins suppress growth of human T-cell leukemia xenografts in vivo. Tagalsins show only minor toxicity on healthy cells and are well tolerated by mice. Our study shows a therapeutic potential of tagalsins for the treatment of hematologic malignancies and a new source of anticancer drugs. PMID:26061604

  1. ATM/ATR-related checkpoint signals mediate arsenite-induced G{sub 2}/M arrest in primary aortic endothelial cells

    Energy Technology Data Exchange (ETDEWEB)

    Tsou, Tsui-Chun; Tsai, Feng-Yuan; Yeh, Szu-Ching; Chang, Louis W. [National Health Research Institutes, Division of Environmental Health and Occupational Medicine, Miaoli County (Taiwan)

    2006-12-15

    Epidemiological studies have demonstrated a high association of inorganic arsenic exposure with vascular disease. Our recent in vitro studies have linked this vascular damage to vascular endothelial dysfunction induced by arsenic exposure. However, cell-cycle arrest induced by arsenic and its involvement in vascular dysfunction remain to be clarified. In this study, we employed primary porcine aortic endothelial cells to investigate regulatory mechanisms of G{sub 2}/M phase arrest induced by arsenite. Our study revealed that lower concentrations of arsenite (1 and 3 {mu}M) increased cell proliferation, whereas higher concentrations of arsenite (10, 20, and 30 {mu}M) inhibited cell proliferation together with correlated increases in G{sub 2}/M phase arrest. We found that this arsenite-induced G{sub 2}/M phase arrest was accompanied by accumulation and/or phosphorylation of checkpoint-related molecules, including p53, Cdc25B, Cdc25C, and securin. Inhibition of activations of these checkpoint-related molecules by caffeine significantly attenuated the 30-{mu}M arsenite-induced G{sub 2}/M phase arrest by 93%. Our data suggest that the DNA damage responsive kinases ATM (ataxia-telangiectasia mutated) and ATR (ATM and Rad3-related) play critical roles in arsenite-induced G{sub 2}/M phase arrest in aortic endothelial cells possibly via regulation of checkpoint-related signaling molecules including p53, Cdc25B, Cdc25C, and securin. (orig.)

  2. The effect of calcium ions and sodium silicate on the adsorption of a model anionic flotation collector on magnetite studied by ATR-FTIR spectroscopy.

    Science.gov (United States)

    Potapova, E; Grahn, M; Holmgren, A; Hedlund, J

    2010-05-01

    Previous studies have shown that agglomeration of the magnetite concentrate after reverse flotation of apatite is negatively affected by the collector species adsorbed on the surface of magnetite. In this work, the effect of ionic strength, calcium ions and sodium silicate on the unwanted adsorption of a model anionic flotation collector on synthetic magnetite was studied in situ using attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR). The amount of collector adsorbed was found to increase with increasing ionic strength at pH 8.5 providing evidence to the contribution of electrostatic forces to the adsorption of the collector. Adding sodium silicate to the system resulted in a threefold decrease in the amount of collector adsorbed compared to when no sodium silicate was added, confirming the depressing activity of sodium silicate on magnetite. Calcium ions were shown to increase the adsorption of both the collector and sodium silicate on magnetite. The depressing effect of sodium silicate on collector adsorption was completely suppressed in the presence of calcium ions under the conditions studied. Furthermore, the amount of collector adsorbed on magnetite from the silicate-collector solution increased 14 times upon addition of calcium ions suggesting that calcium ions in the process water may increase undesired adsorption of the collector on the iron oxide. PMID:20153478

  3. Surficial Siloxane-to-Silanol Interconversion during Room-Temperature Hydration/Dehydration of Amorphous Silica Films Observed by ATR-IR and TIR-Raman Spectroscopy.

    Science.gov (United States)

    Warring, Suzanne L; Beattie, David A; McQuillan, A James

    2016-02-16

    Silica has been frequently studied using infrared and Raman spectroscopy due to its importance in many practical contexts where its surface chemistry plays a vital role. The majority of these studies have utilized chemical-vapor-deposited films in vacuo after high-temperature calcination. However, room-temperature hydration and dehydration of thin silica particle films has not been well characterized in spite of the importance of such films as substrates for polymer and surfactant adsorption. The present study has utilized ATR-IR spectroscopy and thin silica particle films exposed to varying humidity to clearly show reversible conversion between surface siloxanes and hydrogen-bonded silanols without the need for semiempirical peak deconvolution. The IR spectra from corresponding hydration experiments on deuterated silica films has confirmed the vibrational mode assignments. The variation of humidity over silica films formed from silica suspensions of differing pH gave IR spectra consistent with the change in the relative populations of siloxide to silanol surface groups. In addition, total internal reflection Raman spectroscopy has been used to provide further evidence of room-temperature dehydroxylation, with spectral evidence for the presence of three-membered siloxane rings when films are dehydrated under argon. The confirmation of room-temperature siloxane-to-silanol interconversion is expected to benefit understanding in many silica surface chemical contexts. PMID:26804934

  4. Kinetic Parameters during Bis-GMA and TEGDMA Monomer Polymerization by ATR-FTIR: The Influence of Photoinitiator and Light Curing Source

    Directory of Open Access Journals (Sweden)

    Aline B. Denis

    2016-01-01

    Full Text Available This study aimed to analyze the kinetic parameters of two monomers using attenuated total reflectance Fourier transform infrared (ATR-FTIR: 2,2-bis-[4-(2-hydroxy-3-methacryloxypropyl-1-oxy-phenyl] propane (Bis-GMA and triethylene glycol dimethacrylate (TEGDMA. The following were calculated to evaluate the kinetic parameters: maximum conversion rate (Rpmax, time at the maximum polymerization rate (tmax, conversion at Rpmax, and total conversion recorded at the maximum conversion point after 300 s. Camphorquinone (CQ and phenyl propanedione (PPD were used in this study as photoinitiators, whereas N,N-dimethyl-p-toluidine (DMPT amine was used as a coinitiator. LED apparatus and halogen lamp were used in turn to evaluate the effect that light source had on the monomer kinetics. The mass concentration ratio for the three resin preparations was 0.7 : 0.3 for Bis-GMA and TEGDMA: R1 (CQ + DMPT, R2 (PPD + DMPT, and R3 (PPD + CQ + DMPT. The PPD association with the CQ photoinitiator altered the polymerization kinetics compared to a resin containing only the CQ photoinitiator. The light sources exhibited no significant differences for tmax of R1 and R3. Resins containing only the PPD initiator exhibited a higher tmax than those containing only CQ. However, the Rpmax decreased for resins containing the PPD photoinitiator.

  5. In situ ATR-IR spectroscopy study of adsorbed protein: Visible light denaturation of bovine serum albumin on TiO2

    Science.gov (United States)

    Bouhekka, A.; Bürgi, T.

    2012-11-01

    In this work in situ Fourier transform infrared-attenuated total reflection (FTIR-ATR) spectroscopy in a flow-through cell was used to study the effect of visible light irradiation on bovine serum albumin (BSA) adsorbed on porous TiO2 films. The experiments were performed in water at concentrations of 10-6 mol/l at room temperature. The curve fitting method of the second derivative spectra allowed us to explore details of the secondary structure of pure BSA in water and conformation changes upon adsorption as well as during and after illumination by visible light. The results clearly show that visible light influences the conformation of adsorbed BSA. The appearance of a shift of the amide I band, in the original spectra, from 1653 cm-1 to 1648 cm-1, is interpreted by the creation of random coil in the secondary structure of adsorbed BSA. The second derivative analysis of infrared spectra permits direct quantitative analysis of the secondary structural components of BSA, which show that the percentage of α-helix decreases during visible light illumination whereas the percentage of random coil increases.

  6. Noninvasive detection by ATR and NIR-DR methods for skin-care ionic materials transported into the skin by iontophoresis

    Science.gov (United States)

    Ueda, Toyotoshi; Watanabe, Yukio; Akao, Ken-ichi; Suzuki, Harue

    2003-12-01

    Two analytical methods without damage to the skin were proposed in order to detect and measure the quantity of the medication transported into the skin by the iontophoresis. The infrared attenuated total reflection (ATR) method was proven to be able to evaluate the content of such a substance as sodium all- trans-retinoate or magnesium ℓ-ascorbyl-2-phosphate in the top (horny) layer of epidermis (about 1 μm under the skin surface), using characteristic bands to the above ion. Another method of near-infrared diffusive-reflection (NIR-DR) technique was shown probably to detect it in the dermis (1 mm under the surface), based on the shift of frequency and the change in intensity for the vibrational combination band of water molecules hydrating the ion. The quantity of the above material decreased monotonically in the horny layer for several hours after the treatment, while in the dermis it increased at first and then decreased via the maximum value.

  7. A novel mutation in the putative DNA helicase XH2 is responsible for male-to-female sex reversal associated with an atypical form of the ATR-X syndrome

    Energy Technology Data Exchange (ETDEWEB)

    Ion, A.; Telvi, L.; Galacteros, F.; McElreavey, K. [Institut Pasteur, Paris (France)] [and others

    1996-06-01

    We describe a pedigree presenting X-linked severe mental retardation associated with multiple congenital abnormalities and 46,XY gonadal dysgenesis, leading in one family member to female gender assignment. Female carriers are unaffected. The dysmorphic features are similar to those described in the {alpha}-thalassemia and mental retardation (ATR-X) syndrome, although there is no clinical evidence of {alpha}-thalassemia in this family. In addition, the family had other clinical features not previously observed in the ATR-X syndrome, including partial optic-nerve atrophy and partial ocular albinism. Mutations in a putative DNA helicase, termed XH2, have been reported to give rise to the ATR-X syndrome. We screened the YCH2 gene for mutations in affected members of the family and identified a 4-bp deletion at an intron/exon boundary that removes an invariant 3{prime} splice-acceptor site. The mutation cosegregates with the syndrome. The genomic deletion causes missplicing of the pre-mRNA, which results in the loss of 8 bp of coding sequence, thereby generating a frameshift and a downstream premature stop codon. Our finding increases the range of clinical features associated with mutations in the XH2 gene. 17 refs., 4 figs., 2 tabs.

  8. Fuentes de variabilidad en el diagnóstico de gastritis atrófica multifocal asociada con la infección por Helicobacter pylori1

    Science.gov (United States)

    Bravo, Luis Eduardo; Bravo, Juan Carlos; Realpe, José Luis; Zarama, Guillermo; Piazuelo, MarÍa Blanca; Correa, Pelayo

    2014-01-01

    RESUMEN Introducción El mapeo de las diferentes regiones del estómago y el número de fragmentos de mucosa gástrica disponibles para evaluación histopatológica son fuentes importantes de variación en el momento de clasificar y hacer la gradación de la gastritis crónica. Objetivos Estimar la sensibilidad del número de fragmentos de mucosa gástrica necesarios para establecer los diagnósticos de gastritis atrófica con metaplasia intestinal (MI), displasia y estado de infección por Helicobacter pylori. Además evaluar la variabilidad intra-observador en la clasificación de estas lesiones precursoras del cáncer gástrico. Materiales y métodos En una cohorte de 6 años de seguimiento se evaluaron 1,958 procedimientos de endoscopia realizados por dos gastroenterólogos. En cada procedimiento y de cada participante se obtuvieron 5 biopsias de mucosa gástrica que representaban antro, incisura angularis y cuerpo. Un único patólogo hizo la interpretación histológica de las 5 biopsias y proporcionó un diagnóstico definitivo global que se utilizó como patrón de referencia. Cada fragmento de mucosa gástrica examinado condujo a un diagnóstico individual para cada biopsia que se comparó con el patrón de referencia. La variabilidad intra-observador se evaluó en 127 personas que corresponden a una muestra aleatoria de 20% del total de endoscopias hechas a los 72 meses de seguimiento. Resultados La sensibilidad del diagnóstico de MI y displasia gástrica aumentó de manera significativa con el número de fragmentos de mucosa gástrica evaluados El sitio anatómico de mayor sensibilidad para el diagnóstico de MI y displasia fue la incisura angularis. Para descubrir H. pylori se logró alta sensibilidad con el estudio de un solo fragmento de mucosa gástrica (95.9%) y fue independiente del sitio de obtención de la biopsia. El acuerdo intra-observador para el diagnóstico de gastritis crónica fue 86.1% con valor kappa de 0.79 IC 95% (0.76-0.85). Las

  9. Fuentes de variabilidad en el diagnóstico de gastritis atrófica multifocal asociada con la infección por Helicobacter pylori

    Directory of Open Access Journals (Sweden)

    Luis Eduardo Bravo

    2008-03-01

    Full Text Available Introducción: El mapeo de las diferentes regiones del estómago y el número de fragmentos de mucosa gástrica disponibles para evaluación histopatológica son fuentes importantes de variación en el momento de clasificar y hacer la gradación de la gastritis crónica. Objetivos: Estimar la sensibilidad del número de fragmentos de mucosa gástrica necesarios para establecer los diagnósticos de gastritis atrófica con metaplasia intestinal (MI, displasia y estado de infección por Helicobacter pylori. Además evaluar la variabilidad intra-observador en la clasificación de estas lesiones precursoras del cáncer gástrico. Materiales y métodos: En una cohorte de 6 años de seguimiento se evaluaron 1,958 procedimientos de endoscopia realizados por dos gastroenterólogos. En cada procedimiento y de cada participante se obtuvieron 5 biopsias de mucosa gástrica que representaban antro, incisura angularis y cuerpo. Un único patólogo hizo la interpretación histológica de las 5 biopsias y proporcionó un diagnóstico definitivo global que se utilizó como patrón de referencia. Cada fragmento de mucosa gástrica examinado condujo a un diagnóstico individual para cada biopsia que se comparó con el patrón de referencia. La variabilidad intra-observador se evaluó en 127 personas que corresponden a una muestra aleatoria de 20% del total de endoscopias hechas a los 72 meses de seguimiento.Resultados: La sensibilidad del diagnóstico de MI y displasia gástrica aumentó de manera significativa con el número de fragmentos de mucosa gástrica evaluados El sitio anatómico de mayor sensibilidad para el diagnóstico de MI y displasia fue la incisura angularis. Para descubrir H. pylori se logró alta sensibilidad con el estudio de un solo fragmento de mucosa gástrica (95.9% y fue independiente del sitio de obtención de la biopsia. El acuerdo intra-observador para el diagnóstico de gastritis crónica fue 86.1% con valor kappa de 0.79 IC 95% (0

  10. In situ ATR-IR spectroscopy study of adsorbed protein: Visible light denaturation of bovine serum albumin on TiO2

    International Nuclear Information System (INIS)

    Highlights: ► We study the behavior of BSA protein adsorbed on TiO2 using in situ IR spectroscopy. ► We examine the secondary structure changes during light exposure. ► Visible light illumination creates random coil in the secondary structure of BSA. ► The denaturation of BSA adsorbed on TiO2 under visible light irradiation is irreversible. - Abstract: In this work in situ Fourier transform infrared-attenuated total reflection (FTIR-ATR) spectroscopy in a flow-through cell was used to study the effect of visible light irradiation on bovine serum albumin (BSA) adsorbed on porous TiO2 films. The experiments were performed in water at concentrations of 10−6 mol/l at room temperature. The curve fitting method of the second derivative spectra allowed us to explore details of the secondary structure of pure BSA in water and conformation changes upon adsorption as well as during and after illumination by visible light. The results clearly show that visible light influences the conformation of adsorbed BSA. The appearance of a shift of the amide I band, in the original spectra, from 1653 cm−1 to 1648 cm−1, is interpreted by the creation of random coil in the secondary structure of adsorbed BSA. The second derivative analysis of infrared spectra permits direct quantitative analysis of the secondary structural components of BSA, which show that the percentage of α-helix decreases during visible light illumination whereas the percentage of random coil increases.

  11. Determinação quantitativa da concentração de silicone em antiespumantes por espectroscopia FT-IR / ATR e calibração multivariada Quantitative determination of silicone in antifoaming products by FT-IR / ATR spectroscopy and multivariate calibration

    Directory of Open Access Journals (Sweden)

    Marcelo H. F. Garcia

    2004-12-01

    Full Text Available Neste trabalho apresentamos uma alternativa para a dosagem do teor de silicone (polidimetilsiloxano em antiespumantes por meio da técnica de espectroscopia no infravermelho com transformada de Fourier (FT-IR, com a utilização do acessório de reflectância total atenuada (ATR. Os espectros foram registrados na faixa espectral de 2500 a 780 cm-1, com resolução de 4 cm-1 e 128 varreduras. A calibração de um modelo linear por meio da utilização do método de mínimos quadrados parciais (PLS aplicado aos espectros foi capaz de determinar satisfatoriamente a concentração de silicone nas amostras. Este método é de extrema importância para indústrias produtoras de antiespumantes siliconados, uma vez que o desempenho de tais produtos geralmente é avaliado em função da viscosidade dos mesmos. Muitas vezes no processo de fabricação de tais produtos ocorre uma homogeneização incompleta do silicone no solvente, o que leva a resultados de viscosidade que não são representativos das amostras analisadas. A determinação da concentração do teor de silicone é uma importante ferramenta para o Controle Estatístico de Processo (CEP, pois evita o desperdício de matérias-primas empregadas na fabricação dos antiespumantes.This work presents an alternative method to determine the concentration of silicone (polydimethylsiloxane in antifoaming products using Fourier Transformed Infrared Spectroscopy (FT-IR with the attenuated total reflectance (ATR accessory. The spectra were recorded in the range from 2500 to 780 cm-1, with a resolution of 4 cm-1 and 128 scans. With calibration of a linear model using PLS regression method applied to spectral data we were able to determine the silicone concentration in the samples. This method may be useful for antifoaming producers since the performance of such products generally is evaluated as a function of their viscosity. Moreover, during manufacturing an incomplete homogenization of silicone in the

  12. Using ATR-FT/IR molecular spectroscopy to detect effects of blend DDGS inclusion level on the molecular structure spectral and metabolic characteristics of the proteins in hulless barley

    Science.gov (United States)

    Zhang, Xuewei; Yu, Peiqiang

    2012-09-01

    The objectives of this study were to investigate the effects of inclusion of a bioethanol co-product of blend DDGS (wheat:corn = 70%:30%) on protein molecular structure spectral and metabolic characteristics in hulless barley-based feed using ATR-FT/IR molecular spectroscopy. Hulless barley grain with the blend DDGS were mixed in the five ratios. The results showed that when blend DDGS was included at an increased ratio, predicted truly absorbed protein supply was highly and linearly increased (P products for dairy and beef cattle.

  13. En pos del <> a través del <>. El cuarto de atrás de Carmen Martín Gaite y Don Julián de Juan Goytisolo.

    OpenAIRE

    Valle Collado, Mélanie

    2008-01-01

    En este trabajo, se analiza El cuarto de atrás de Carmen Martín Gaite y Don Julián de Juan Goytisolo en relación con el concepto de metaficción. Consideramos que los autores consiguieron rescatar y transmitir su experiencia del pasado sin caer en los tópicos ni las ideas impuestas porque, en ellas, se aventuraron en un nuevo modelo formal (fuera del realismo social). En el primer apartado, veremos cómo las obras muestran su proceso de gestación y qué papel desarrolla la inte...

  14. Análisis comparativo para la búsqueda de un patrón en la realización de un doble mortal atrás con pirueta de salida en anillas

    OpenAIRE

    Miralles, K.; García, M.; Navarro, E

    2003-01-01

    El presente estudio ha sido realizado gracias a la colaboración del INEF de Madrid con el Equipo Nacional de Gimnasia Artística. Empleando fotogrametría tridimensional se ha comparado la técnica de ejecución de un doble mortal atrás con pirueta de salida en anillas de 3 gimnastas. El patrón de eficacia que vamos a utilizar la nota que el entrenador, haciendo las veces de juez, va a determinar, así catalogamos en un primer momento las ejecuciones analizadas. Como premisas supone...

  15. AGR-2 Data Qualification Report for ATR Cycles 151B-2, 152A, 152B, 153A, 153B and 154A

    Energy Technology Data Exchange (ETDEWEB)

    Binh T. Pham; Jeffrey J. Einerson

    2013-09-01

    This report documents the data qualification status of AGR-2 fuel irradiation experimental data from Advanced Test Reactor (ATR) Cycles 152A, 152B, 153A, 153B, and 154A, as recorded in the Nuclear Data Management and Analysis System (NDMAS). The AGR-2 data streams addressed include thermocouple (TC) temperatures, sweep gas data (flow rate, pressure, and moisture content), and fission product monitoring system (FPMS) data for each of the six capsules in the experiment. A total of 13,400,520 every minute instantaneous TC and sweep gas data records were received and processed by NDMAS for this period. Of these data, 8,911,791 records (66.5% of the total) were determined to be Qualified based on NDMAS accuracy testing and data validity assessment. For temperature, there were 4,266,081 records (74% of the total TC data) that were Failed due to TC instrument failures. For sweep gas flows, there were 222,648 gas flow records (2.91% of the flow data) that were Failed. The inlet gas flow failures due to gas flow cross-talk and leakage problems that occurred after Cycle 150A were corrected by using the same gas mixture in all six capsules and the Leadout. For FPMS data, NDMAS received and processed preliminary release rate and release-to-birth rate ratio (R/B) data for three reactor cycles (Cycles 149B, 150B, and 151A) . This data consists of 45,983 release rate records and 45,235 R/B records for the 12 radionuclides reported. The qualification status of these FPMS data has been set to In Process until receipt of Quality Assurance-approved data generator reports. All of the above data have been processed and tested using a SAS®-based enterprise application software system, stored in a secure Structured Query Language database, made available on the NDMAS Web portal (http://ndmas.inl.gov), and approved by the INL STIM for release to both internal and appropriate external Very High Temperature Reactor Program participants.

  16. Ablation of burned skin with ultra-short pulses laser to promote healing: evaluation by optical coherence tomography, histology, μATR-FTIR and Nonlinear Microscopy

    International Nuclear Information System (INIS)

    Burns cause changes in the anatomical structure of the skin associated with trauma. The severity of the burn injury is divided into first, second and third-degree burns. The third-degree burns have been a major focus of research in search of more conservative treatments and faster results in repair for a functional and cosmetically acceptable. The conventional treatment is the use of topical natural or synthetic skin graft. An alternative therapy is the laser ablation process for burned tissue necrosis removal due to the no mechanical contact, fast application and access to difficult areas. The purpose of this study is to evaluate the feasibility of using high intensity femtosecond lasers as an adjunct treatment of burned patients. For this study, 65 Wistar rats were divided into groups of five animals: healthy skin, burned skin, two types of treatment (surgical debridement or femtosecond laser ablation) and four different times in the healing process monitoring. Three regions of the back of the animals were exposed to steam source causing third-degree burn. On the third day after the burn, one of the regions was ablated with high intensity ultrashort laser pulses (λ = 785 nm, 90 fs, 2 kHz and 10 μJ/ pulse), the other received surgical debridement, and the last was considered the burn control. The regions were analyzed by optical coherence tomography (OCT), histology, attenuated total reflectance infrared spectroscopy using Fourier transform (μ-ATR-FTIR), two-photon excitation fluorescence microscopy (TPEFM) and second harmonic generation technique (SHG) on days 3, 5, 7 and 14 pos-treatments. The results showed that with the laser irradiation conditions used it was possible to remove debris from third degree burn. The techniques used to characterize the tissue allowed to verify that all treatments promoted wound healing. On the fourteenth day, the regeneration curve showed that the attenuation coefficient of laser ablated tissue converges to the values of

  17. ATR alterations in Hodgkin's lymphoma

    NARCIS (Netherlands)

    Liu, Angen; Takakuwa, Tetsuya; Fujita, Shigeki; Luo, Wen-Juan; Tresnasari, Kristianti; Van den Berg, Anke; Poppema, Sibrand; Aozasa, Katsuyuki

    2008-01-01

    Hodgkin's lymphoma (HL) is characterized by the presence of neoplastic Hodgkin and Reed-Sternberg cells (HRSC) in a background of inflammatory cells. Free radicals and oxidative stress generated in the inflammatory lesions could cause DNA damage, thus providing a basis for lymphomagenesis. Ataxia-te

  18. Automatic Traffic Recorder (ATR) Stations

    Data.gov (United States)

    Department of Homeland Security — The data included in the GIS Traffic Stations Version database have been assimilated from station description files provided by FHWA for Weigh-in-Motion (WIM), and...

  19. Use of total internal reflection Raman (TIR) and attenuated total reflection infrared (ATR-IR) spectroscopy to analyze component separation in thin offset ink films after setting on coated paper surfaces.

    Science.gov (United States)

    Kivioja, Antti; Hartus, Timo; Vuorinen, Tapani; Gane, Patrick; Jääskeläinen, Anna-Stiina

    2013-06-01

    The interactive behavior of ink constituents with porous substrates during and after the offset print process has an important effect on the quality of printed products. To help elucidate the distribution of ink components between the retained ink layer and the substrate, a variety of spectroscopic and microscopic analysis techniques have been developed. This paper describes for the first time the use of total internal reflection (TIR) Raman spectroscopy to analyze the penetration behavior of separated offset ink components (linseed oil, solid color pigment) in coated papers providing chemically intrinsic information rapidly, nondestructively, and with minimal sample preparation. In addition, the already widely applied technique of attenuated total reflection infrared spectroscopy (ATR-IR) was evaluated in parallel and compared. The results of the ATR-IR Raman clearly revealed an improvement in uppermost depth resolution compared with values previously published from other nondestructive techniques, and the method is shown to be capable of providing new knowledge of the setting of thin (0.25-2 μm) offset ink films, allowing the spreading and the penetration behavior on physically different paper coating surfaces to be studied. PMID:23735252

  20. Effect of pH on the Nitrite Hydrogenation Mechanism over Pd/Al2O3 and Pt/Al2O3: Details Obtained with ATR-IR Spectroscopy

    DEFF Research Database (Denmark)

    Ebbesen, Sune Dalgaard; Mojet, Barbara L.; Lefferts, Leon

    2011-01-01

    on catalytic surfaces in water. In this paper, the influence of pH was studied on adsorption and subsequent hydrogenation of nitrite in water between pH 5 and 9 over Pd/Al2O3 and Pt/Al2O3, using ATR-IR spectroscopy. On both catalysts, pH clearly influenced the surface coverage and reaction rates of......It is well-known that activity and selectivity to N2 during nitrite hydrogenation over noble metal catalysts in water depend on the pH of the solution, but mechanistic understanding is lacking. Attenuated total reflection infrared (ATR-IR) spectroscopy is an ideal tool to perform detailed studies...... intermediates. For Pt/Al2O3, lowering the pH induced the increasing surface coverage of key reaction intermediates like NOsteps1620cm−1 and “HNO”(ads)1540cm−1, as well as increased hydrogenation rates, explaining the higher TOF at lower pH as reported in the literature. For Pd/Al2O3, the effect of pH on...

  1. Interaction of U(VI) with Äspö diorite: A batch and in situ ATR FT-IR sorption study

    International Nuclear Information System (INIS)

    atmosphere. The U species in aqueous solution as well as sorbed on diorite were studied by in situ time-resolved attenuated total reflection Fourier-transform infrared (ATR FT-IR) spectroscopy. A predominant sorbing species containing a UO2(CO3)34− moiety was identified. The extent of U sorption onto diorite was found to depend more on the low sorption affinity of the Ca2UO2(CO3)3(aq) complex than on reduction processes of uranium

  2. Attenuated Total Reflection Fourier Transform Infrared Spectroscopy (ATR FT-IR) Mapping Coupled with Multivariate Curve Resolution (MCR) for Studying the Miscibility of Chlorobutyl Rubber/Polyamide-12 Blends.

    Science.gov (United States)

    Tang, Yongjiao; Jing, Nan; Zhang, Pudun

    2015-11-01

    A series of chlorobutyl rubber/polyamide-12 (CIIR/PA-12) blends compatibilized by different amounts of maleic anhydride (MAH) grafted polypropylene (PP-g-MAH) were investigated by attenuated total reflection Fourier transform infrared spectroscopy (ATR FT-IR) mapping. Multivariate curve resolution (MCR) was used to process the FT-IR images. Both the spectra of pure components in the blends and their concentration distributions in a micro-region were acquired. Our results demonstrated that the blend with 15 parts per hundred rubber PP-g-MAH showed the best miscibility. An amide interphase and an imide interphase were inferred by analyzing the spectra of MCR component 3 of the blends with and without PP-g-MAH, respectively. Correspondingly, two different compatibilizing mechanisms were proposed for these blends. PMID:26647055

  3. Ablation of burned skin with ultra-short pulses laser to promote healing: evaluation by optical coherence tomography, histology, {mu}ATR-FTIR and Nonlinear Microscopy; Ablacao de pele queimada com laser de pulsos ultra-curtos para promocao da cicatrizacao: avaliacao por tomografia por coerencia optica, histologia, {mu}ATR-FTIR e microscopia nao-linear

    Energy Technology Data Exchange (ETDEWEB)

    Santos, Moises Oliveira dos

    2012-07-01

    Burns cause changes in the anatomical structure of the skin associated with trauma. The severity of the burn injury is divided into first, second and third-degree burns. The third-degree burns have been a major focus of research in search of more conservative treatments and faster results in repair for a functional and cosmetically acceptable. The conventional treatment is the use of topical natural or synthetic skin graft. An alternative therapy is the laser ablation process for burned tissue necrosis removal due to the no mechanical contact, fast application and access to difficult areas. The purpose of this study is to evaluate the feasibility of using high intensity femtosecond lasers as an adjunct treatment of burned patients. For this study, 65 Wistar rats were divided into groups of five animals: healthy skin, burned skin, two types of treatment (surgical debridement or femtosecond laser ablation) and four different times in the healing process monitoring. Three regions of the back of the animals were exposed to steam source causing third-degree burn. On the third day after the burn, one of the regions was ablated with high intensity ultrashort laser pulses ({lambda} = 785 nm, 90 fs, 2 kHz and 10 {mu}J/ pulse), the other received surgical debridement, and the last was considered the burn control. The regions were analyzed by optical coherence tomography (OCT), histology, attenuated total reflectance infrared spectroscopy using Fourier transform ({mu}-ATR-FTIR), two-photon excitation fluorescence microscopy (TPEFM) and second harmonic generation technique (SHG) on days 3, 5, 7 and 14 pos-treatments. The results showed that with the laser irradiation conditions used it was possible to remove debris from third degree burn. The techniques used to characterize the tissue allowed to verify that all treatments promoted wound healing. On the fourteenth day, the regeneration curve showed that the attenuation coefficient of laser ablated tissue converges to the values

  4. Simulated Microgravity Promotes Cell Apoptosis Through Suppressing Uev1A/TICAM/TRAF/NF-κB-Regulated Anti-Apoptosis and p53/PCNA- and ATM/ATR-Chk1/2-Controlled DNA-Damage Response Pathways.

    Science.gov (United States)

    Zhao, Tuo; Tang, Xin; Umeshappa, Channakeshava Sokke; Ma, Hong; Gao, Haijun; Deng, Yulin; Freywald, Andrew; Xiang, Jim

    2016-09-01

    Microgravity has been known to induce cell death. However, its underlying mechanism is less studied. In this study, BL6-10 melanoma cells were cultured in flasks under simulated microgravity (SMG). We examined cell apoptosis, and assessed expression of genes associated with apoptosis and genes regulating apoptosis in cells under SMG. We demonstrate that SMG induces cell morphological changes and microtubule alterations by confocal microscopy, and enhances apoptosis by flow cytometry, which was associated with up- and down-regulation of pro-apoptotic and anti-apoptotic genes, respectively. Moreover, up- and down-regulation of pro-apoptotic (Caspases 3, 7, 8) and anti-apoptotic (Bcl2 and Bnip3) molecules was confirmed by Western blotting analysis. Western blot analysis also indicates that SMG causes inhibition of an apoptosis suppressor, pNF-κB-p65, which is complemented by the predominant localization of NF-κB-p65 in the cytoplasm. SMG also reduces expression of molecules regulating the NF-κB pathway including Uev1A, TICAM, TRAF2, and TRAF6. Interestingly, 10 DNA repair genes are down-regulated in cells exposed to SMG, among which down-regulation of Parp, Ercc8, Rad23, Rad51, and Ku70 was confirmed by Western blotting analysis. In addition, we demonstrate a significant inhibition of molecules involved in the DNA-damage response, such as p53, PCNA, ATM/ATR, and Chk1/2. Taken together, our work reveals that SMG promotes the apoptotic response through a combined modulation of the Uev1A/TICAM/TRAF/NF-κB-regulated apoptosis and the p53/PCNA- and ATM/ATR-Chk1/2-controlled DNA-damage response pathways. Thus, our investigation provides novel information, which may help us to determine the cause of negative alterations in human physiology occurring at spaceflight environment. J. Cell. Biochem. 117: 2138-2148, 2016. © 2016 Wiley Periodicals, Inc. PMID:26887372

  5. Detect changes in lipid-related structure of brown- and yellow-seeded Brassica Carinata seed during rumen fermentation in relation to basic chemical profile using ATR-FT/IR molecular spectroscopy with chemometrics

    Science.gov (United States)

    Xin, Hangshu; Yu, Peiqiang

    2014-12-01

    In this experiment, brown- and yellow-seeded Brassica carinata were selected to use as a model to investigate whether there were any changes in lipid-related structure make-up (including CH3 and CH2 asymmetric and symmetric stretching bands ca. 3010-2765 cm-1, unsaturated lipid band ca. 3043-2987 cm-1 and carbonyl Cdbnd O ester band ca. 1789-1701 cm-1) of oilseed tissue during rumen in situ incubation using attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FT/IR). Correlations of lipid spectral characteristics with basic chemical profile and multivariate analyses for clarifying structural differences within lipid regions between two carinata seeds were also measured. The results showed that most spectral parameters in both carinata seeds were reduced as incubation time increased. However, the extent of changes in peak intensity of carbonyl Cdbnd O ester group of brown-seeded carinata was not in fully accordance with that of yellow-seeded carinata. Additionally, these lipid structure features were highly correlated with the concentrations of OM (positively), CP (positively), NDF (negatively) and EE (positively) in carinata seeds after 0, 12, 24 and 48 h of incubation. Based on the results from multivariate analyses, neither AHCA nor PCA could produce any distinctions in rumen residues between brown- and yellow-seeded carinata in spectra at lipid regions. It was concluded that besides for original feed samples, spectroscopic technique of ATR-FT/IR could also be used for rumen degradation residues in detecting changes in lipid-related molecular structure make-up. Further studies are needed to explore more details in lipid metabolism during ruminal fermentation with the combined consideration on both metabolic basis and molecular structural basis.

  6. Using ATR-FT/IR to detect carbohydrate-related molecular structure features of carinata meal and their in situ residues of ruminal fermentation in comparison with canola meal

    Science.gov (United States)

    Xin, Hangshu; Yu, Peiqiang

    2013-10-01

    There is no information on the co-products from carinata bio-fuel and bio-oil processing (carinata meal) in molecular structural profiles mainly related to carbohydrate biopolymers in relation to ruminant nutrition. Molecular analyses with Fourier transform infrared spectroscopy (FT/IR) technique with attenuated total reflectance (ATR) and chemometrics enable to detect structural features on a molecular basis. The objectives of this study were to: (1) determine carbohydrate conformation spectral features in original carinata meal, co-products from bio-fuel/bio-oil processing; and (2) investigate differences in carbohydrate molecular composition and functional group spectral intensities after in situ ruminal fermentation at 0, 12, 24 and 48 h compared to canola meal as a reference. The molecular spectroscopic parameters of carbohydrate profiles detected were structural carbohydrates (STCHO, mainly associated with hemi-cellulosic and cellulosic compounds; region and baseline ca. 1483-1184 cm-1), cellulosic compounds (CELC, region and baseline ca. 1304-1184 cm-1), total carbohydrates (CHO, region and baseline ca. 1193-889 cm-1) as well as the spectral ratios calculated based on respective spectral intensity data. The results showed that the spectral profiles of carinata meal were significantly different from that of canola meal in CHO 2nd peak area (center at ca. 1091 cm-1, region: 1102-1083 cm-1) and functional group peak intensity ratios such as STCHO 1st peak (ca. 1415 cm-1) to 2nd peak (ca. 1374 cm-1) height ratio, CHO 1st peak (ca. 1149 cm-1) to 3rd peak (ca. 1032 cm-1) height ratio, CELC to total CHO area ratio and STCHO to CELC area ratio, indicating that carinata meal may not in full accord with canola meal in carbohydrate utilization and availability in ruminants. Carbohydrate conformation and spectral features were changed by significant interaction of meal type and incubation time and almost all the spectral parameters were significantly decreased (P

  7. De El cuarto de atrás de Carmen Martín Gaite a La meitat de l’ànima de Carme Riera: Notas sobre la memoria histórica en la novela contemporánea / From Carmen Martín Gaite’s El cuarto de atrás to Carme Riera’s La meitat de l’ànima: Some notes on historical memory in contemporary fiction

    Directory of Open Access Journals (Sweden)

    Mario Santana

    2011-01-01

    Full Text Available Resumen: La novela española contemporánea ha dado una relevancia especial al interés por recuperar y transmitir la memoria colectiva del pasado reciente. Si bien la denominada “novela de memoria” (HERZBERGER, 1995 ya es una constante en la producción narrativa desde los primeros años de la transición a la democracia, este ensayo propone que en la última década ha ido ganando popularidad una “novela de la memoria histórica” con rasgos estructurales y temáticos que la convierten en una modalidad diferenciada. A partir del concepto de memoria heteropática (SILVERMAN, 1996 y del estudio de las semejanzas y diferencias entre dos novelas paradigmáticas de uno y otro modelo narrativo —El cuarto de atrás de Carmen Martín Gaite (1978 y La meitat de l’ànima de Carme Riera (2004, respectivamente—, se identifican algunos de los rasgos más distintivos de la novela de la memoria histórica y en especial su articulación literaria de la memoria como proyecto colectivo y ciudadano.Summary: The recovery and transmission of collective memory about the recent past plays an important role in contemporary Spanish fiction. While the production of “novels of memory” (HERZBERGER, 1995 has been consistent since the beginning of the transition to democracy, this essay proposes that in the last decade has gained popularity a “novel of historical memory”, which has distinctive estructural and thematic features and deserves to be studied as a differentiated modality. Using as a point of departure the notion of heteropathic memory (SILVERMAN, 1996 and through the analysis of the parallels and differences between two novels representative of both models —Carmen Martín Gaite’s El cuarto de atrás (1978 and Carme Riera’s La meitat de l’ànima (2004, respectively—, the essay identifies some of the most distinctive features of the novel of historical memory and, in particular, the literary articulation of memory as a collective and

  8. Effects of arsenic trioxide on ATM/ATR gene expression and cell apoptosis in K562 cells%As2O3对K562 ATM/ATR基因表达和细胞凋亡的影响

    Institute of Scientific and Technical Information of China (English)

    叶敏军; 任行洲

    2008-01-01

    目的 探讨不同浓度As2O3对K562细胞ATM(Ataxia Telangiectasia Mutated)/ATR(ATM-Rad3-Related)基因表达的影响及相应的细胞周期变化和细胞凋亡机制.方法 以不同剂量的As2O3作用于K562细胞株,RT-PCR半定量检测ATM/ATR基因表达,流式细胞术检测P53、Annexin V和细胞周期.结果 随药物浓度升高,ATM基因表达量增强而ATR基因表达量降低,P53水平升高,细胞凋亡显著,亚二倍体和G1期细胞数增多,S期和G2/M期细胞减少.不加入药物的K562细胞ATM和ATR几乎不表达.结论 ATM和ATR基因表达变化呈As203浓度依赖的形式,且与P53水平、细胞周期和细胞凋亡率的改变相关.

  9. Perbedaan Post Purchase Regret Berdasarkan Perilaku Pada Konsumen Wanita

    OpenAIRE

    Fardhani, Diah

    2014-01-01

    Post purchase regret is a negative emotion of consumer after evaluating the purchase decision has been made, the evaluation is conducted based on the outcome and process of consumer decision making. This study was a comparative quantitative study aimed to determine differences on post purchase regret based on unplanned and substitute purchasing behavior. The research hypothesis was the differences in post purchase regret based on unplanned behavior and substitute purchasing. The study involve...

  10. PERAMALAN BISNIS BERDASARKAN PERILAKU KONSUMEN MENGGUNAKAN LOGIKA FUZZY

    Directory of Open Access Journals (Sweden)

    Aryanti Aryanti

    2014-02-01

    Full Text Available Perkembangan teknologi informasi sekarang ini telah melahirkan sistem cerdas. Aplikasi dari sistem cerdas dapat digunakan untuk peramalan. Salah satu metode dalam sistem cerdas yang dapat digunakan untuk melakukan peramalan adalah menggunakan logika fuzzy. Penelitian dilakukan dengan memprediksi seberapa jauh keberhasilan bisnis yang akan atau sedang dikerjakan. Sebuah bisnis akan dapat dijalankan dan mampu bertahan dalam era persaingan yang ketat jika perusahaan mampu memperhatikan kepuasan pelanggan atau konsumennya. Perilaku konsumen tidak terlepas dari karakteristik produk baik mengenai penampilan, gaya, mutu dan harga dari produk tersebut. Pada penelitian ini dibangun model regresi menggunakan logika fuzzy antara tingkat pendidikan, pendapatan dan kemampuan membeli seseorang. Model regresi ini diharapkan akan mampu melakukan peramalan tentang bisnis yang akan dijalankan. Pada penelitian ini diperoleh bahwa jika sebagian besar suatu wilayah berpenduduk dengan tingkat pendidikan mahasiswa dan pendapatan sekitar Rp.1 juta maka dapat diduga bahwa keputusan akan pembelian produk sebesar 76.3 atau konsumen akan mampu untuk mengeluarkan dana sebesar 7.63% dari pendapatannya untuk membeli produk. Kata Kunci: Peramalan, Perilaku Konsumen, Logika Fuzzy 

  11. ANALISIS KUALITAS LULUSAN BERDASARKAN TINGKAT KEPUASAN PENGGUNA LULUSAN

    OpenAIRE

    Ira Setyaningsih; Muchammad Abrori

    2013-01-01

    In education, the students are the products to be input and the output are graduates. Users of graduates are consumers who need to know the level of satisfaction to provide a self-evaluation in improving the institutions. It is also stated in the accreditation forms BAN PT. However, a grain questions that sought to know is very little. The research was conducted at a university in Yogyakarta. Research trying to describe in detail the attributes of quality of graduates based on the user satisf...

  12. Pembuatan Komposit Termoplastik Berdasarkan Serat Kelapa Sawit Dengan Kaedah Prapreg

    OpenAIRE

    Maulida

    2010-01-01

    The aim of this project to expand the prepreg concept to non non-continuous based fibers, especially agriculture waste and other waste materials like as palm fiber, newspaper fiber and rice husk fiber. Akrylonytrille butadiene styrene (ABS) is used as the matrix, meanwhile methyl ethyl cetone (MEK) acts as the solvent. The scope of the study on the resin mixing technique with known amount with ratio 1 : 1. The resin mixing technique with known amount (method B) produces prepregs with varying ...

  13. PENGELOMPOKKAN KABUPATEN DI PROVINSI BALI BERDASARKAN PERKEMBANGAN FASILITAS PARIWISATA

    OpenAIRE

    NOVA SARI BARUS; I PUTU EKA NILA KENCANA; KOMANG GDE SUKARSA

    2013-01-01

    The development of tourism facilities in each district/city between districts with each district is different. The purpose of this study was to determine the grouping of several districts in the province of Bali is based on the number of tourism facilities as well as what the variable identifier of each group. The analysis used in this study is the analysis of clusters and Biplot. The data used is secondary data obtained from the Bali Tourism Office in 2011. Variables used are classified hote...

  14. Pembangunan Berkelanjutan Berdasarkan Konsep Tri Hita Karana untuk Kegiatan Ekowisata

    Directory of Open Access Journals (Sweden)

    I Wayan Runa

    2015-10-01

    Full Text Available AbstractBalinese society has from a long time ago managedand developed their land based on environmentallyfriendly principles. These principles have been inspired byimplementations of the Balinese Tri Hita Karana conception. Thisarticle attempts to explain various spatial developments relatingto ecotourism activities that are founded by Tri Hita Karanavalues and practices. It constructs its arguments by conductingan intensive literature study to review relevant hypotheses andconcepts proposed by scholars in the field. The article concludesthat ecotourism is a form of environmentally friendly touristdevelopments and is seen to be the most sustainable modelfor future’s tourism. The article completes its conclusion byunderlining that for its success, ecotourism related developmentpractices should be first understood. It then should come witha certain framework and standard for its implementations. Bestpractices pertaining to the ecotourism development should becertified and accessible by public and others parties involved. Inaddition to these remarks, the article conclusively proposes TriHita Kharana conception as a framework that offers guidancefor sustainably developed ecotourism. This local concept alsoprovides direction as to how its development and its impact onspatial development can be approached and managed, especiallyto the case of Bali.

  15. ANALISIS CITRA PERMUKAAN THERMOCHROMIC LIQUID CRYSTAL BERDASARKAN NILAI STATISTIK HUE

    OpenAIRE

    Risti Suryantari; - Flaviana

    2014-01-01

    Tujuan dari penelitian ini adalah untuk mengamati perbedaan citra pada permukaan Thermocromic Liquid Crystal (TLC) R25C5W akibat perubahan temperatur. Metode yang digunakan untuk analisis adalah pengolahan citra berbasis morfologi matematika menggunakan perangkat lunak Matlab2013a. Citra asli yang diperoleh dalam bentuk RGB dikonversi menjadi HSV (hue, saturation, value), dengan mengambil komponen hue saja. Proses utama yang digunakan adalah opening dengan struktur elemen (SE) line. Berdasark...

  16. PENGELOMPOKKAN KABUPATEN DI PROVINSI BALI BERDASARKAN PERKEMBANGAN FASILITAS PARIWISATA

    Directory of Open Access Journals (Sweden)

    NOVA SARI BARUS

    2013-11-01

    Full Text Available The development of tourism facilities in each district/city between districts with each district is different. The purpose of this study was to determine the grouping of several districts in the province of Bali is based on the number of tourism facilities as well as what the variable identifier of each group. The analysis used in this study is the analysis of clusters and Biplot. The data used is secondary data obtained from the Bali Tourism Office in 2011. Variables used are classified hotel, non-classified hotels, home stays, restaurants, bars, tourist destination, the area of ??tourism, water tourism and business. The results of this study formed three groups: group 1 Bangli, Buleleng, Jembrana District, Klungkung, Karangasem district and Denpasar City. Group 2 and group 3 Badung district of Gianyar district. Variable identifier is a restaurant for all variables.

  17. EKUITAS MEREK JASA GERAI BUAH-BUAHAN BERDASARKAN PERSEPSI KONSUMEN

    OpenAIRE

    Erdiasa Nursaman; Ujang Sumarwan; Setiadi Djohar

    2015-01-01

    The need of fruits and the number of fruit outlets in Jakarta has been increasing, therefore the study on brand equity of fruit outlet services according to consumer’s perception is now required. In detail the purpose of this study is to analyze the demographic characteristics of  fruits outlets consumer in Jakarta, analyzing the factors that affect brand equity of fruits outlets services, analyze the level of contribution of brand equity variables fruits outlets service in Jakarta and analyz...

  18. Penentuan Umur Bercak Darah Manusia Berdasarkan Perubahan Warna

    OpenAIRE

    Harianja, Dessy Darmayani

    2011-01-01

    Background: Most criminal cases with physical abuse such as murder, torturing, raping and so on may be found blood, sperm, saliva, urine, hair or others anatomic tissue in crime scene. To identify the time of physical abuse that resulting injured victim and leave blood spots that can be found in crime scene, where there’s no eye witness that seen the incident need observations and accurate and proper method. Observation regarding the changing color of the blood spots have ever been done b...

  19. Keanekaragaman Mirabilis jalapa L. Berdasarkan Pola Pita Isozim Peroksidase

    Directory of Open Access Journals (Sweden)

    AHMAD DWI SETYAWAN

    2007-05-01

    Full Text Available Mirabilis jalapa L. is a gardening plant which growth easily planted because their beautiful color and flower’s ornaments. The aims of the research were to find out the variation of isozyme band of peroxidase (PER and their close relationship of M. jalapa cultivated based on their different flower’s color. The method used in this study was polyacrilamide gel electrophoresis. The collecting data were analyzed using calculation of association coefficient (Gower’s coefficient with cluster analysis used for similarities of their arithmetic. The results showed that in M. jalapa were found 21 variation of isozyme bands of peroxidase (PER from 8 Rf of 0.04; 0.08; 0.20; 0.28; 0.36; 0.48; 0,60; and 0.64. M. jalapa with white and red nodes flower’s (BIN and white and red line flower’s (GAR have the nearest genetic relationship with similarity index of 0.76. M. jalapa with white and red nodes flower’s (BIN and white and red line flower’s (GAR joined with red flower’s (MER on 0.73 of similarity index then joined with white flower’s (PUT on 0.64 of similarity index and yellow flower’s (KUN on0.49 of similarity index. At least, M. jalapa with orange flower’s (ORA joined with M. jalapa cultivars on 0.41 of similarity index.

  20. Penentuan Konsentrasi Tanah dalam Air Sungai Berdasarkan Perbedaan Warna

    Directory of Open Access Journals (Sweden)

    Imam Sofi'i

    2008-08-01

    Full Text Available Information of soil erosion is very useful related with prevention action and planning in the future. The objective of this research is to determine soil concentration in water river based on colour differences using image processing and artificial neural network (ANN. Soil and water mixture image was taken using a digital camera then was processed by an image processing program. Two ANN Models were developed. The first model had 3 input parameters while the second model had 6 input parameters. Both models had altogether one output parameters of the soil concentration. The accuracy of the first model was 38% while the second one was 36%.

  1. Penentuan Nilai Noise Berdasarkan Slice Thickness Pada Citra CT Scan

    OpenAIRE

    Sihombing, Hediana

    2015-01-01

    Noise measurements have been carried out with changes in thick slices CT Scan image by selecting the ROI on a water phantom objects. The method used in the measurement of noise values ranging from 1 mm, 2 mm, 3 mm, 4 mm, 5 mm, 6 mm, 7 mm, 8 mm, 9 mm, and 10 mm and eksposi factor of 100 kV and 500 mAs. The results obtained are 6.32 HU; 5:14 HU; 3.86 HU; HU 3:48; HU 3:14; 2.94 HU; 2.78 HU; 2.52 HU; HU HU 2:44 and 2:38. The thicker slices diminishing the noise then the resulting CT images wer...

  2. Preferensi Konsumen Terhadap Merek Smartphone Berdasarkan Sistem Operasi

    OpenAIRE

    Atmodjo, Giovanni Evangelista

    2016-01-01

    Penelitian ini bertujuan menganalisis hubungan antara OS yang digunakan saat ini, preferensi terhadap merek smartphone, dan hubungan antara fitur smartphone dan pemilihan merek smartphone berbasis OS Android. Sampel dari penelitian ini adalah warga di Yogyakarta yang menggunakan smartphone. Teknik pengambilan sampel dilakukan dengan Convenience Sampling. Pengumpulan data dalam penelitian ini dilakukan dengan membagikan kuisioner kepada 156 responden. Hasil dalam penelitia...

  3. Khazana Warna Berdasarkan Hasana Alam dan Budaya Nusantara (1)

    OpenAIRE

    Mita Purbasari Wahidiyat; R. A. Diah Resita I. K. Jakti

    2011-01-01

    Using colors for designing purpose is become an important part of designer, such as graphic designer, interior, product, least but not last for architect and artist. Like humans, color need to have a name to identify according to its character, psychology and emotional effect. This research applied the qualitative and quantitative method to give a brief description about colors name and propose new color naming which based on character, nature, and imagery it evokes. This research...

  4. ALOKASI PASOKAN BERDASARKAN PRODUK UNGGULAN UNTUK RANTAI PASOK SAYURAN SEGAR

    Directory of Open Access Journals (Sweden)

    Marimin Marimin

    2007-01-01

    Full Text Available Application of artificial inteligent by using fuzzy logic can be one of way to handle supply chain situation in uncertainty environment. It was widely concern to study a supply chain using fuzzy logic that most needed. Ain of the study was apply fuzzy logic in determination of supply allocation for superior product in vegetables supply chain. Models was developed in three sub models. First was determination vegetables types that superior by using pareto technique and exponential compaarison method (MPE. Second was expert system to determine supply needed and finally was optimizing supply allocation using fuzzy multi-objective linear programming. The model was applied in a vegetables agroindustry that superior product selected was red paprica. Analysis againts model behaviour is conducted for pesimistic and optimistic scenarios. Abstract in Bahasa Indonesia : Penerapan kecerdasan buatan dengan logika fuzzy bisa menjadi salah satu cara untuk mengatasi situasi rantai pasok dalam lingkungan ketidakpastian. Perhatian yang lebih luas untuk pembahasan rantai pasok menggunakan teknik fuzzy masih sangat dibutuhkan. Studi ini bertujuan menerapkan logika fuzzy dalam penentuan alokasi pasokan untuk produk unggulan pada rantai pasok agroindustri sayuran. Model yang terdiri dari tiga sub model. Sub model pertama adalah penentuan jenis sayuran yang diunggulkan menggunakan kombinasi teknik pareto dan metode perbandingan eksponensial (MPE. Sub model kedua adalah sistem pakar untuk menentukan kebutuhan pasokan menggunakan logika fuzzy. Sub model ketiga adalah optimasi alokasi pasokan menggunakan programa linear obyektif majemuk fuzzy. Model yang dibangun kemudian diterapkan pada sebuah perusahaan agroindustri sayuran dengan produk unggulan terpilih adalah paprika merah. Analisis terhadap prilaku model juga dilakukan untuk skenario pesimis dan optimis. Kata kunci: fuzzy, sistem pakar, MPE, obyektif majemuk, sayuran

  5. Redesain Meja dan Kursi Kelas Berdasarkan Antropometri Siswa SDN 060796

    OpenAIRE

    Silvia

    2015-01-01

    Perabot kelas, yang terdiri dari meja dan kursi, merupakan fasilitas fisik yang penting karena aktivitas belajar siswa, seperti membaca, menggambar, menulis dan kegiatan lainnya, banyak dihabiskan di dalam kelas. Antropometri merupakan faktor penting yang harus dipertimbangkan dalam perancangan perabot kelas guna menentukan dimensi perabot kelas yang tepat dan dapat memfasilitasi pengguna dengan sikap duduk yang baik. Penelitian ini berlokasi di Sekolah Dasar Negeri 060796 Kecamatan Medan Are...

  6. ANALISIS KUALITAS LULUSAN BERDASARKAN TINGKAT KEPUASAN PENGGUNA LULUSAN

    Directory of Open Access Journals (Sweden)

    Ira Setyaningsih

    2013-06-01

    Full Text Available In education, the students are the products to be input and the output are graduates. Users of graduates are consumers who need to know the level of satisfaction to provide a self-evaluation in improving the institutions. It is also stated in the accreditation forms BAN PT. However, a grain questions that sought to know is very little. The research was conducted at a university in Yogyakarta. Research trying to describe in detail the attributes of quality of graduates based on the user satisfaction level graduates. Object of study is alumni and also alumni users. The study was conducted during the months of August to November 2012. Attributes used are Communication Skills, Organizational Skills, Leadership, Logic, Effort, Ethics, Group and Other Skills. Other attributes are attributes about the ability of areas of expertise. From the results obtained, the attributes that need attention are Organizational Skills and Leadership with the highest gap -0.82. Overall, users of alumni do not feel satisfied, because all negative attributes.

  7. Pengembangan Pembelajaran IPS SD Berdasarkan Preskripsi Component Display Theory (CDT)

    OpenAIRE

    Dwi Nugroho Hidayanto

    2016-01-01

    High quality of instructional design is needed to reach high instructional quality. It should be designed based on the assumption that different types of conditions and learner outcomes required different methods. In fact, this assumption has been ignored by the social studies teachers. It brings on low quality of instruction. Component Display Theory (CDT) model gives a set of instructional prescriptions based on the link and match of condition variables and those of the methods. CDT is comi...

  8. The influence of ATM, ATR, DNA-PK inhibitors on the cytotoxic and genotoxic effects of dibenzo[def,p]chrysene on human hepatocellular cancer cell line HepG2.

    Science.gov (United States)

    Spryszyńska, Sylwia; Smok-Pieniążek, Anna; Ferlińska, Magdalena; Roszak, Joanna; Nocuń, Marek; Stępnik, Maciej

    2015-09-01

    The effect of inhibitors of phosphatidylinositol-3-kinase related kinases (PIKK): ataxia-telangiectasia mutated (ATM), ATM- and Rad3-related (ATR) and DNA-dependent protein kinase (DNA-PK) on the response of HepG2 human liver cancer cells to dibenzo[def,p]chrysene (DBC) was investigated. High cytotoxicity of DBC (IC50=0.1μM) was observed after 72h incubation. PIKK inhibitors: KU55933 (5μM), NU7026 (10μM) or caffeine (1 and 2mM) when used alone did not significantly influence the cytotoxicity. However, two combinations: KU55933/NU7026 and caffeine/NU7026 significantly increased HepG2 viability (by 25%) after treatment with DBC at 0.5μM. The cytoprotective effect was confirmed by cell cycle and apoptosis/necrosis analysis. DNA damage level after exposure to DBC assessed by comet assay (single strand breaks) showed a long persistence and significant decrease after incubation of the cells in the presence the inhibitors (the combination of KU55933+NU7026 showed the strongest effect). Weak induction of reactive oxygen species (ROS) by DBC (0.5μM) was observed. Although, KU55933 and NU7026 when used alone did not increase ROS levels in the cells, their combination induced the ROS increase and moderately enhanced ROS generation by DBC. We propose a mechanism how cells with damaged DNA after exposure to DBC and under the condition of PIKK inhibition, may be at higher risk of undergoing malignant transformation. PMID:26338538

  9. In vitro evaluation of ionizing radiation effects in bone tissue by FTIR spectroscopy and dynamic mechanical analysis; Avaliacao in vitro dos efeitos da radiacao ionizante em tecido osseo bovino por espectroscoia ATR-FTIR e analise dinamica-mecanica

    Energy Technology Data Exchange (ETDEWEB)

    Veloso, Marcelo Noronha

    2013-07-01

    Ionizing radiation from gamma radiation sources or X-ray generators is frequently used in Medical Science, such as radiodiagnostic exams, radiotherapy, and sterilization of haloenxerts. Ionizing radiation is capable of breaking polypeptidic chains and causing the release of free radicals by radiolysis.of water. It interacts also with organic material at the molecular level, and it may change its mechanical properties. In the specific case of bone tissue, studies report that ionizing radiation induces changes in collagen molecules and reduces the density of intermolecular crosslinks. The aim of this study was to verify the changes promoted by different doses of ionizing radiation in bone tissue using Fourier Transform Infrared Spectroscopy (FTIR) and dynamic mechanical analysis (DMA). Samples of bovine bone were irradiated using Cobalt-60 with five different doses: 0.01 kGy, 0.1 kGy, 1 kGy, 15 kGy and 75 kGy. To study the effects of ionizing irradiation on the chemical structure of the bone, the sub-bands of amide I, the crystallinity index and relation of organic and inorganic materials, were studied. The mechanical changes were evaluated using the elastic modulus and the damping value. To verify whether the chemical changes and the mechanical characteristics of the bone were correlated, the relation between the analysis made with spectroscopic data and the mechanical analysis data was studied. It was possible to evaluate the effects of different doses of ionizing radiation in bone tissue. With ATR-FTIR spectroscopy, it was possible to observe changes in the organic components and in the hydroxyapatite crystals organization. Changes were also observed in the elastic modulus and in the damping value. High correlation with statistical significance was observed among (amide III + collagen)/{sub v1,v3}, PO{sub 4}{sup 3-} and the delta tangent, and among 1/FHWM and the elastic modulus. (author)

  10. Direct determination of sorbitol and sodium glutamate by attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR) in the thermostabilizer employed in the production of yellow-fever vaccine.

    Science.gov (United States)

    de Castro, Eduardo da S G; Cassella, Ricardo J

    2016-05-15

    Reference methods for quality control of vaccines usually require treatment of the samples before analysis. These procedures are expensive, time-consuming, unhealthy and require careful manipulation of the sample, making them a potential source of analytical errors. This work proposes a novel method for the quality control of thermostabilizer samples of the yellow fever vaccine employing attenuated total reflectance Fourier transform infrared spectrometry (ATR-FTIR). The main advantage of the proposed method is the possibility of direct determination of the analytes (sodium glutamate and sorbitol) without any pretreatment of the samples. Operational parameters of the FTIR technique, such as the number of accumulated scans and nominal resolution, were evaluated. The best conditions for sodium glutamate were achieved when 64 scans were accumulated using a nominal resolution of 4 cm(-1). The measurements for sodium glutamate were performed at 1347 cm(-1) (baseline correction between 1322 and 1369 cm(-1)). In the case of sorbitol, the measurements were done at 890cm(-1) (baseline correction between 825 and 910 cm(-1)) using a nominal resolution of 2 cm(-1) with 32 accumulated scans. In both cases, the quantitative variable was the band height. Recovery tests were performed in order to evaluate the accuracy of the method and recovery percentages in the range 93-106% were obtained. Also, the methods were compared with reference methods and no statistical differences were observed. The limits of detection and quantification for sodium glutamate were 0.20 and 0.62% (m/v), respectively, whereas for sorbitol they were 1 and 3.3% (m/v), respectively. PMID:26992492

  11. Alternativas a la elevación de seno maxilar: rehabilitación del sector posterior del maxilar atrófico mediante implantes pterigoideos Alternatives to maxillary sinus lift: posterior area of the atrophic maxilla rehabilitation by means pterigoideal implants

    Directory of Open Access Journals (Sweden)

    X. Rodríguez-Ciurana

    2008-12-01

    Full Text Available El primer y segundo molar son los dientes que se pierden más a menudo debido a la enfermedad periodontal y al exceso de fuerzas oclusales. A pesar de la frecuencia del edentulismo parcial del sector posterior raramente se ubican los implantes más allá de los premolares debido al aumento del índice de fallos. El escaso volumen óseo y la pobre mineralización del sector posterior del maxilar comprometen la viabilidad de las rehabilitaciones con implantes a largo plazo. Además, la cresta ósea a nivel del seno maxilar, en el maxilar atrófico, no suele permitir el anclaje de implantes de 10 mm. Se han propuesto varias técnicas para rehabilitar el sector posterior del maxilar atrófico: implantes cortos, extensiones protésicas, injerto sinusal, implante cigomático. El implante pterigoideo es otro de los posibles tratamientos para rehabilitar el sector posterior del maxilar atrófico. Anclado en el hueso cortical de la apófisis del esfenoides el implante pterigoideo evita la necesidad de injertar o utilizar extensiones protésicas. El objetivo de este artículo es analizar las indicaciones, la técnica, complicaciones y supervivencia del implante pterigoideo en el sector posterior del maxilar atrófico.The first and second molar are the teeth most commonly lost in the maxilla, mainly due to periodontal disease and excessive occlusal force. 1 Although partial edentulism of the posterior maxilla is common, implants are seldom placed distal to the premolars because failure rates in the posterior maxilla have historically been high. Poor volume and low density of bone are the worst conditions for long-term anchorage in the maxilla. 7 Moreover, bone under the maxillary sinus, in the atrophic maxilla, is usually insufficient to enable placement of 10 mm implants. Several techniques have been proposed to restore the atrophic posterior maxilla: short implants, prosthetic cantilevers, sinus bone graft, zigomatic fixtures. Pterygoid implants are

  12. Protected Plutonium Production by Transmutation of Minor Actinides for Peace and Sustainable Prosperity - Irradiation Tests of Np and Np-U Samples in Experimental Fast Reactor Joyo (JAEA) and Advanced Thermal Reactor ATR (INL)

    International Nuclear Information System (INIS)

    authors would like to express their deep appreciation to Dr. Marshall, Dr. Chang, Dr. Foster and INL staffs for ATR irradiation test. This work has been supported by the Ministry of Education, Culture, Sports, Science and Technology. (authors)

  13. Applying target shadow models for SAR ATR

    Science.gov (United States)

    Papson, Scott; Narayanan, Ram M.

    2007-04-01

    Recent work has suggested that target shadows in synthetic aperture radar (SAR) images can be used effectively to aid in target classification. The method outlined in this paper has four steps - segmentation, representation, modeling, and selection. Segmentation is the process by which a smooth, background-free representation of the target's shadow is extracted from an image chip. A chain code technique is then used to represent the shadow boundary. Hidden Markov modeling is applied to sets of chain codes for multiple targets to create a suitable bank of target representations. Finally, an ensemble framework is proposed for classification. The proposed model selection process searches for an optimal ensemble of models based on various target model configurations. A five target subset of the MSTAR database is used for testing. Since the shadow is a back-projection of the target profile, some aspect angles will contain more discriminatory information then others. Therefore, performance is investigated as a function of aspect angle. Additionally, the case of multiple target looks is considered. The capability of the shadow-only classifier to enhance more traditional classification techniques is examined.

  14. Notes on the 2015 ATRS World Conference

    OpenAIRE

    KİRACI, Kasım

    2015-01-01

    Abstract. In this study, the evaluation of the 19.The ATSR (The Air Transport Research Society) World Conference held between 2-5 July 2015 in Singapore will be mentioned.Keywords. Civil Aviation, World Conference, Singapore.JEL. L62, L93.

  15. Miniplates irradiation in the ATR (Idaho, USA)

    International Nuclear Information System (INIS)

    High density U Mo alloys are promising for its utilization in the reconversion of HEU fuels to LEU for research nuclear reactors. Ought to the thermomechanical properties of the alloy U Mo and its interaction with aluminium it is necessary to develop new technologies and fabrication procedures to qualify this material as a nuclear fuel. In this work a review is made about the evolution of the idea and PIE experiments of monolithic LEU U 7 Mo fuel with Zr-4 cladding. The irradiation took place in the frame of international qualification efforts of dispersed and monolithic U Mo fuels. Dispersed and monolithic fuels, elaborated and in intermediate steps of development, are discussed. (author)

  16. SAR ATR Based on Convolutional Neural Network

    Directory of Open Access Journals (Sweden)

    Tian Zhuangzhuang

    2016-06-01

    Full Text Available This study presents a new method of Synthetic Aperture Radar (SAR image target recognition based on a convolutional neural network. First, we introduce a class separability measure into the cost function to improve this network’s ability to distinguish between categories. Then, we extract SAR image features using the improved convolutional neural network and classify these features using a support vector machine. Experimental results using moving and stationary target acquisition and recognition SAR datasets prove the validity of this method.

  17. SAR ATR Based on Convolutional Neural Network

    OpenAIRE

    Tian Zhuangzhuang; Zhan Ronghui; Hu Jiemin; Zhang Jun

    2016-01-01

    This study presents a new method of Synthetic Aperture Radar (SAR) image target recognition based on a convolutional neural network. First, we introduce a class separability measure into the cost function to improve this network’s ability to distinguish between categories. Then, we extract SAR image features using the improved convolutional neural network and classify these features using a support vector machine. Experimental results using moving and stationary target acquisition and recogni...

  18. Rapid Isolation of Phenol Degrading Bacteria by Fourier Transform Inf rared (FTIR) Spectroscopy%利用衰减全反射傅里叶红外光谱(ATR-FTIR)技术快速筛选可降解苯酚菌株

    Institute of Scientific and Technical Information of China (English)

    李霏; 宋文军; 魏纪平; 王素英; 刘崇基

    2015-01-01

    Phenol is an important chemical engineering material and ubiquitous in industry wastewater ,its ex-istence has become a thorny issue in many developed and developing country .More and more stringent stand-ards for effluent all over the world with human realizing the toxicity of phenol have been announced .Many ad-vanced biological methods are applied to industrial wastewater treatment with low cost ,high efficiency and no secondary pollution ,but the screening of function microorganisms is certain cumbersome process .In our study a rapid procedure devised for screening bacteria on solid medium can degrade phenol coupled with attenuated total reflection fourier transform infrared (ATR-FTIR) which is a detection method has the characteristics of efficient ,fast ,high fingerprint were used .Principal component analysis (PCA) is a method in common use to extract fingerprint peaks effectively ,it couples with partial least squares (PLS) statistical method could estab-lish a credible model .The model we created using PCA-PLS can reach 99.5% of coefficient determination and validation data get 99.4% ,which shows the promising fitness and forecasting of the model .The high fitting model is used for predicting the concentration of phenol at solid medium where the bacteria were grown .The highly consistent result of two screening methods ,solid cultural with ATR-FTIR detected and traditional liq-uid cultural detected by GC methods ,suggests the former can rapid isolate the bacteria which can degrade sub-strates as well as traditional cumbersome liquid cultural method .Many hazardous substrates widely existed in industry wastewater ,most of them has specialize fingerprint peaks detected by ATR-FTIR ,thereby this detec-ted method could be used as a rapid detection for isolation of functional microorganisms those can degrade many other toxic substrates .%苯酚是一种重要的化工原料并广泛存在于工业废水中,随着各国对苯酚生物毒性的认识,排放

  19. The ectopic newly-formed nerve fibres which repopulate the long-time denervated and atrophic chick skeletal muscle Fibras nervosas neo-formadas que repopulam músculo estriado desnervado e atrófico de "Gallus domesticus"

    Directory of Open Access Journals (Sweden)

    Eros Abrantes Erhart

    1968-09-01

    ós-operatórios, é demonstrado, confirmando trabalhos anteriores, que tais ventres distais, embora totalmente separados dos correspondentes proximais, apresentam evidente repopulação de fibras nervosas (Figs. 5 e 6 que restabelecem, inclusive, suas conexões com fibras musculares estriadas (Fig. 7. A despeito do aspecto atrófico, esses ventres distais desnervados experimentalmente há 3 ou mais meses, quando estimulados com 1,5 V, respondem com evidentes contrações, e, quando neles são implantados, com técnica cirúrgica adequada, o correspondente músculo homônimo, contralateral, íntegro (Fig. 3, há possibilidade de recuperação funcional em cerca de 30 dias.

  20. Research on Rapid Discrimination of Edible Oil by ATR Infrared Spectroscopy%衰减全反射红外光谱法快速分类和识别多种食用油的方法

    Institute of Scientific and Technical Information of China (English)

    马啸; 袁洪福; 宋春风; 胡爱琴; 李效玉; 赵众; 李秀琴; 国振; 朱志强

    2015-01-01

    A rapid discrimination method of edible oils ,KL‐BP model ,was proposed by attenuated total reflectance infrared spectroscopy .The model extracts the characteristic of classification from source data by KL and reduces data dimension at the same time .Then the neural network model is constructed by the new data which as the input of the model .84 edible oil samples which include sesame oil ,corn oil ,canola oil ,blend oil ,sunflower oil ,peanut oil ,olive oil ,soybean oil and tea seed oil ,were collected and their infrared spectra determined using an ATR FT‐IR spectrometer .In order to compare the method performance , principal component analysis (PCA) direct‐classification model ,KL direct‐classification model ,PLS‐DA model ,PCA‐BP model and KL‐BP model are constructed in this paper .The results show that the recognition rates of PCA ,PCA‐BP ,KL ,PLS‐DA and KL‐BP are 59.1% ,68.2% ,77.3% ,77.3% and 90.9% for discriminating the 9 kinds of edible oils ,respectively .KL extracts the eigenvector which make the distance between different class and distance of every class ratio is the largest .So the method can get much more classify information than PCA .BP neural network can effectively enhance the classification ability and accuracy . Taking full of the advantages of KL in extracting more category information in dimension reducing and the features of BP neural network in self‐learning ,adaptive ,nonlinear ,the KL‐BP method has the best classification ability and recognition accuracy and great importance for rapidly recognizing edible oil in practice .%提出了一种衰减全反射红外光谱法快速分类和识别多种食用油的方法———KL‐BP模型。此模型利用KL算法对原始光谱数据分类特征进行提取并对原始数据降维,降维后的数据作为神经网络的输入建立分析模型。实验共收集了九种食用油包括芝麻油、玉米油、油菜籽油、调和油、葵花油、花生油、橄榄油

  1. Cirurgia laparoscópica no diagnóstico de gastrite crônica atrófica seguida de tratamento clínico em cadela: relato de caso Laparoscopic surgery in the diagnosis of atrophic gastritis in a dog followed by clinical treatment: case report

    Directory of Open Access Journals (Sweden)

    P.C. Basso

    2007-10-01

    Full Text Available Descrevem-se o diagnóstico e o tratamento de um caso de gastrite atrófica crônica, em uma cadela sem raça definida, de dois anos de idade. A paciente apresentava como principal sintomatologia vômito crônico. O hemograma, a urinálise e as avaliações bioquímicas séricas não revelaram alterações significativas. Os exames radiológicos e ultra-sonográficos abdominais também não foram sugestivos de alterações. Realizaram-se inspeção da cavidade peritoneal, gastrotomia, gastroscopia, gastrectomia para biopsia e gastrorrafia intracorpórea videolaparoscópicas. Constatou-se ausência de rugosidades estomacais. Ao exame histológico, observou-se atrofia das células principais e parietais da mucosa gástrica. O quadro clínico permitiu o diagnóstico de gastrite crônica atrófica. O animal foi medicado com terapia imunossupressora e apresentou remissão completa dos sinais clínicos.This report describes a case of chronic atrophic gastritis. A two-year-old female mongrel dog showed chronic emesis. The complete blood count serum chemistry and urinalysis values were within the normal limits. Radiographs revealed no alterations. Abdominal evaluation, gastrotomy, gastroscopy, gastrectomy and intracorporeal stomach suture were done by laparoscopic approach. Absence of gastric villous was noticed through laparoscopic biopsy. The microscopic analysis reveled parietal and principal gastric mucosal cells atrophy, which, associated with clinical signs, allowed the chronic atrophic gastritis diagnosis. The animal was treated and clinical signs complete remission was observed.

  2. Distracción osteogénica alveolar: una alternativa en la reconstrucción de rebordes alveolares atróficos: Descripción de 10 casos Alveolar distraction osteogenesis: an alternative in the reconstruction of atrophic alveolar ridges: Report of 10 cases

    Directory of Open Access Journals (Sweden)

    P.E. Maurette O’Brien

    2004-02-01

    Full Text Available La distracción osteogénica alveolar (DOA es un método alternativo para la reconstrucción de rebordes alveolares atróficos que ofrece un resultado previsible y que disminuye los tiempo de espera entre la reconstrucción del reborde alveolar atrófico y la colocación de los implantes óseo-integrados, en comparación con los métodos tradicionalmente utilizados. Fueron atendidos 10 pacientes que presentaban deficiencia de reborde alveolar mandibular y/o maxilar por medio de distracción osteogénica, utilizando un dispositivo yuxtaoseo (Conexión Implant System® - SP-Brasil. Todos los pacientes fueron atendidos de forma ambulatoria, bajo anestesia local y sedación conciente, comenzando la activación del dispositivo a los 7 días posteriores a la instalación, con un patrón de activación de 1 mm diarios hasta alcanzar la altura ósea deseada. Posteriormente se aguardaron 10 semanas como parte del periodo de consolidación ósea y se realizo la colocación de los implantes oseointegrados y local y el retiro del dispositivo de distracción, pudiéndose comprobar clínica y radiográficamente la ganancia de la altura y volumen óseo necesario para la rehabilitación por medio de implantes.The alveolar distraction osteogenesis is an alternative method for the reconstruction of atrophic alveolar ridges with success, that decrease the time of wait between the reconstruction of the alveolar ridge and the placement of the osseointegrated implants in comparison with the traditionally used methods. 10 patients that presented deficiency of the alveolar ridge in the maxilla and/or mandible were assisted by means of distraction osteogenesis, using a juxtaosseous device (Conexion Implant System® - SP-Brazil. All the patients were assisted of form ambulatory, under local anesthesia and conscientious sedation, beginning the activation from the device 7 days later to the installation, with a pattern of activation 1 mm diary until reaching the wanted

  3. Nondestructive Determination of the Age of 20th-Century Oil-Binder Ink Prints Using Attenuated Total Reflection Fourier Transform Infrared Spectroscopy (ATR FT-IR): A Case Study with Postage Stamps from the Łódź Ghetto.

    Science.gov (United States)

    Bower, Nathan W; Blanchet, Conor J K; Epstein, Michael S

    2016-01-01

    The ability to determine the production date for a painting or print would be of great benefit in the forensic detection of fakes and forgeries as well as in art history and conservation. Changes in the pigments used at different times have been invaluable in detecting incongruities that suggest fraud, but relatively little work has been published that uses the chemical changes in oil binders as they dry to determine when an ink print or an oil painting was made. Using attenuated total reflectance-Fourier transform infrared (ATR FT-IR) spectroscopy and samples with known dates, we calibrate the drying of oil binders in inks and paints and cross-validate the paints with pyrolysis-gas chromatography-mass spectrometry (Py-GC-MS). We apply the ink calibration to a case study involving the age determination of possible philatelic counterfeits from a World War II Jewish Ghetto in Occupied Poland, obtaining a date of 1946 ± 6 (1 s, n = 9) for the genuine stamps, and 1963 ± 16 (1 s, n = 19) for the various reproductions. PMID:26767642

  4. 75 FR 8476 - Airworthiness Directives; ATR-GIE Avions de Transport Régional Model ATR42 and ATR72 Airplanes

    Science.gov (United States)

    2010-02-25

    ... FURTHER INFORMATION CONTACT: Tom Rodriguez, Aerospace Engineer, International Branch, ANM-116, Transport... Engineer, International Branch, ANM-116, Transport Airplane Directorate, FAA, 1601 Lind Avenue, SW., Renton... extinguishers, usually fitted or stowed in aircraft passenger cabins and flight decks. EASA published...

  5. 77 FR 67557 - Special Conditions: ATR-GIE Avions de Transport Regional, Models ATR42-500 and ATR72-212A...

    Science.gov (United States)

    2012-11-13

    ... Privacy Act Statement can be found in the Federal Register published on April 11, 2000 (65 FR 19477-19478... electronic form of all comments received into any FAA docket, including the name of the individual sending... configuration may allow the exploitation of network security vulnerabilities resulting in intentional...

  6. Reconstrução do seio maxilar atrófico com enxerto autólogo de crista ilíaca: avaliação por tomografia computadorizada e radiografia panorâmica Autologus crest iliac graft in the reconstruction of resorbed maxillary sinus: evaluation through computed tomography and panoramic radiography

    Directory of Open Access Journals (Sweden)

    André Luíz Zétola

    2002-02-01

    Full Text Available OBJETIVOS: As dificuldades para a utilização de implantes dentários osteointegrados em pacientes portadores de atrofia do seio maxilar justificaram o emprego de enxerto autólogo não vascularizado de crista ilíaca isolado ou associado à hidroxiapatita (HA em 14 pacientes submetidos a 25 procedimentos no Hospital das Nações, Curitiba, Paraná, portadores de atrofia do sinus maxilar. O objetivo foi avaliar comparativamente a precisão da tomografia computadorizada e da radiografia panorâmica, através da quantificação da neoformação óssea nesta estrutura. MÉTODOS: Foram selecionadas pacientes edentados, com altura óssea residual do rebordo gengival ao soalho do seio maxilar menor que 5mm. O enxerto medular de crista ilíaca fragmentada isolado ou misturado com HA foi colocado através da parede lateral no soalho atrófico da cuba maxilar por via submucosa. A avaliação quantitativa e qualitativa foi feita através da radiografia panorâmica e tomografia computadorizada, sendo utilizado na análise estatística a distribuição t de Student (prevalência de 0,05 para análise das variâncias, considerado que a leitura dos laudos radiológicos foi feita por dois especialistas, medindo a distância entre os pontos inferiores e superiores do enxerto no soalho do seio maxilar. RESULTADOS: Tivemos um ganho médio de 14,8mm em todos os procedimentos, com um erro maior que 3mm em 16 procedimentos (64% e incorporação satisfatória do enxerto ósseo suficiente para futuro implante dentário. CONCLUSÕES: A tomografia computadorizada foi o método de escolha na avaliação qualitativa e quantitativa da incorporação de enxerto autólogo não vascularizado em seio maxilar atrófico.BACKGROUND:There are different methods to evaluate bone grafts in the maxillary sinus. Panoramic radiography is the most common one, even though assessment could be difficult. Occasionaly computerized tomography (CTis another option but cost and radiation in

  7. Pengajaran Lingkungan Rumah Berdasarkan Kepedulian pada Kehidupan Murid SD Sehari-hari

    Directory of Open Access Journals (Sweden)

    Laurens Kaluge

    2016-02-01

    Full Text Available This study examined the Sidoarjo School Improvement Program (SSIP, after a year in action, emphasizing the teaching improvement based on the current concepts of effective teaching. The Social Studies particularly on home environment was the case of application. There were 19 primary schools involved as the experimental and 15 as the control schools, involving 781 Grade 3 pupils representing the urban, semi-urban, and rural subdistricts. The data were collected by using intelligence test, content-related test, questionnaire for pupils and parents, inventories, and open questionnaires. After controlling for the childs ability (intelligence, gender, parental occupation and education, family supports, self-concept, democratic atmosphere, and locus of control; no difference was found among urban, semi-urban, and rural schools. However, the most striking result was that the SSIP made a difference, the attainments of children at experimental schools were higher than those at the control schools.

  8. Pemberian Pupuk N, P, dan K Berdasarkan Pengelolaan Hara Spesifik Lokasi untuk Meningkatkan Produktivitas Kedelai (Review

    Directory of Open Access Journals (Sweden)

    KARSIDI PERMADI

    2016-01-01

    Full Text Available Applicationof N, P, and K Fertilizer Based on Site-Specific Nutrient Management for An increase of Productivity of Soybean. Soybean productivity in Indonesia is still low, it is about 1.25 t ha-1.This is due to the same dose of fertilizer in all location.In this case, fertilization is on the recommendation i.e. 25-75 kg urea ha-1 + 50-100 kg SP-36 ha-1 + 50-100 kg KCl ha-1 for soybean in all locations.Though each location farmland have different levels of soil fertility. Soybean commodities can compete with other plants when minimum productivity of 2.18 t ha-1 of dry beans, it is able to provide a higher profit than corn. To that end, soybean fertilizer recommended by site-specific nutrient management (SSNM by using the method of paddy soil test device, and dry soil test device that can determine soil nutrient classes to categories of low, medium and high.N fertilizer on soil classes, including low, medium, and high dose respectively at 174, 152, and 117 kg urea ha-1. For P fertilizer application on soil nutrient classes, including low, medium, and high doserespectively at 104,80, and 40 kg ha-1 SP-36. Likewise K fertilizer application on soil nutrient classes, including low, medium, and high each at doses of 210, 190, and 150 kg ha-1 KCl. In addition, supported by the use of new varieties of soybean large seed that high productivity and achieve the results expected in all locations soybean.Then the government provides support for input subsidies in the form of primary production facilities such as seed, fertilizer, and pesticides that farmers are interested in returning to planting soybeans and soybean prices ensure incentives for farmers. Things like this will spur farmers to increase productivity so that soybean self-sufficiency is achieved. In the end domestic soybean demand can be met so that the government no longer to import soybeans.

  9. Alat Pemisah Benda Berdasarkan Warna Menggunakan Sensor TCS230 Berbasis Mikrokontroler AT89S51.

    OpenAIRE

    Victor Chandra S

    2011-01-01

    Was design an instrumental for differentiate and then separate an object. Separation was done by the color. To differentiated the color was used a TCS230 color sensor. The TCS230 color sensor output is a frequency. Frequency of this sensor was get from reflected light by the object. To reflect the light was use a white LED (Light Emitting Diode), without other light source. A good frequency output was get by positioning the object right in front of the sensor with range 1 milimeter. To get a ...

  10. Rancang Bangun Alat Ukur Tingkat Kerusakan Oli Mesin Berdasarkan Konstanta Dielektrik Berbasis PC

    OpenAIRE

    Sitorus, Jansius D

    2015-01-01

    Has conducted an identification of changes in the level of damage to the engine oil by identifying changes in the dielectric constant indicated the output voltage changes the occur in a system tool that has been designed and constructed. Capasitive transducer is made by utilizing the conductor plate parallel to indentify changes in the dielectric medium using sinusoidal electric wave propagation. Observations carried out by measuring the amplitude of the wave attenuation due to the interactio...

  11. Informasi Kebakaran Hutan dan Lahan Berdasarkan Indeks Kekeringan dan Titik Panas di Kabupaten Samosir

    OpenAIRE

    Perangin-angin, Perdamean Abadi

    2015-01-01

    Fire is one cause damaging to forest and land run quick and make a great impact. Economic lossed is estimated approximately 10 bilion dollars. To reduce fire effct are needed fire management and early warning. One of the efforts to suggest is adopting the information system on fire. The objective of research are to know fire danger rating on Samosir from the year 2009, 2010 and 2011.The data analysis we conducted in laboratory of forest inventory Departemen Faculty Of Agriculture adopted ther...

  12. Sistem Informasi Ekstensibilitas E-Commerce Berdasarkan Data Trafik Menggunakan Statistik Proses Kontrol

    Directory of Open Access Journals (Sweden)

    Andi Gunawan

    2014-01-01

    Full Text Available The concept of quality control has been widely used in companies for the fulfillment of customer satisfaction on products produced. Loss of customers due to in appropriate quality standards are important avoided by the company. This study aims to establish quality control information system e-Commerce in the diagram view map control. In this study, it is used Statistic Process Control (SPC method. In the early stages, e-Commerce is assumed to have  met  with quality variable of EWAM  method. Transaction visitation opportunities at a certain period used as a parameter of quality, and is called extensibility. The visitation data were collected by web traffic and applications and transaction data that occur in e-Commerce. Waterfall model approach was used in the prototype development process. The results of this  study  was  the  extensibility  of  e-Commerce  information  system.  Automation  of  data  collection  occurs  in  real  time  information system, so  that the e-Commerce extensibility statements can be  continuously  monitored. Analysis of results displayed by the  control chart suggested that a sustain effort in the control of extensibility can provide benefits in an effort to retain customers while management can  use  number  of  extensibility  variable  in  increasing  profitability  of  the  company  or  the  consideration  of  using  e -Commerce. Completion  of  e-Commerce  extensibility  can  gradually  be  increased  through  the  reduction  of  extensibility  variation,  while  the improvement of extensibility relies on the reparation of e-Commerce systems associated with EWAM variable.Keywords : E-Commerce; Web traffic; Extensibility;  Quality control; Automation

  13. Analisis keragaman genetik manggis (Garcinia mangostana diiradiasi dengan sinar gamma berdasarkan penanda ISSR

    Directory of Open Access Journals (Sweden)

    ALFIN WIDIASTUTI

    2013-05-01

    Full Text Available Widiastuti A, Sobir, Suhartanto MR. 2013. Genetic variability analysis of mangosteen (Garcinia mangostana irradiated by gamma ray based on ISSR marker. Bioteknologi 10: 15-22. The aim of the research was to know the increasing of genetic variation within mangosteen based on banding pattern of ISSR marker as a response to some doses of irradiation gamma rays. Five dosages of irradiation gamma rays were 0 Gy, 20 Gy, 25 Gy, 30 Gy, 35 Gy and 40 Gy. The source of the seed that have been irradiated was from Cegal, Leuwiliang, Bogor. The results showed that gamma ray irradiation affecting mangosteen genetic changed. Because the randomize of gamma irradiation, it changed was individually. Gamma irradiation successfully increase genetic variability (5%.

  14. Analisis keragaman genetik manggis (Garcinia mangostana) diiradiasi dengan sinar gamma berdasarkan penanda ISSR

    OpenAIRE

    ALFIN WIDIASTUTI; SOBIR; MUH. R. SUHARTANTO

    2013-01-01

    Widiastuti A, Sobir, Suhartanto MR. 2013. Genetic variability analysis of mangosteen (Garcinia mangostana) irradiated by gamma ray based on ISSR marker. Bioteknologi 10: 15-22. The aim of the research was to know the increasing of genetic variation within mangosteen based on banding pattern of ISSR marker as a response to some doses of irradiation gamma rays. Five dosages of irradiation gamma rays were 0 Gy, 20 Gy, 25 Gy, 30 Gy, 35 Gy and 40 Gy. The source of the seed that have been irradiate...

  15. Hubungan FIB-4 Index Dengan Derajat Fibrosis Hati Pada Hepatitis B Kronik Berdasarkan Fibroscan

    OpenAIRE

    Siregar, Yuswita Santi

    2016-01-01

    Introduction : The accurate evaluation of liver fibrosis in chronic liver disease is mandatory to appraise therapeutic indications and prognosis, because complications mainly occur in patients in advanced stages of their disease. Noninvasive test to asses hepatic fibrosis have been developed, wich combine several biochemical parameters. Transient elastography (FibroSscan) a morphological method that measures liver stiffnes has been evaluated. Aim : To evaluate the correlation of FIB-...

  16. PENGELOMPOKAN BERBAGAI MERK MI INSTAN BERDASARKAN KEMIRIPAN KANDUNGAN GIZI DENGAN MENGGUNAKAN ANALISIS BIPLOT

    OpenAIRE

    AGUSTINUS ANGELAUS ETE; NI LUH PUTU SUCIPTAWATI; DESAK PUTU EKA NILAKUSMAWATI

    2014-01-01

    At this time, almost everyone once to consume instant noodles. The high interest of public on the instant noodles should be balanced with enough knowledge about the noodles and its nutritional content, either on it’s instant noodles which have similar nutrient content and nutrient content that become identifier of each this group of noodles. The method can be used to obtain information on several brands of instant noodles that have similar nutrient content and nutrient content type that becom...

  17. Revenue Discretionary Model Pengukuran Manajemen Laba: Berdasarkan Sektor Industri Manufaktur di Bursa Efek Indonesia

    OpenAIRE

    Nieken Herma Sari; Nurmala Ahmar

    2014-01-01

    Earnings management is a management action to manage the profitability of a company. The purpose of this study is to indicate the accrual earning management using revenue discretionary model. This study adopts the research conducted by Stubben (2010) where there are two measurement models to detect the presence of accrual earnings management. The measurement model is the discretionary revenue model consists of conditional revenue model and revenue model. Object of this research is the compani...

  18. Manfaat Informasi Akuntansi Untuk Memprediksi Risiko Investasi Saham Berdasarkan Pendekatan Decision Usefulness

    Directory of Open Access Journals (Sweden)

    Zarah Puspitaningtyas

    2010-12-01

    Full Text Available This study is to explain the usefulness of accounting information to predict the risk of stock investment based on the decision usefulness approach, technically shown through the effect of variable accounting on risk of stock investment. Based on analysis of 13 companies over a period of five years (2001-2005 by using multiple linear regression, the model shows that the current ratio significantly influence the risk of stock investment. However, signs of regression coefficients are not consistent with the predictions of the study. The results indicate that the current ratio has positive influence on the risk of stock investment. F test shows that the regression model with the current ratio as independent variables significantly influence the risk of stock investment. Meanwhile, the regression model with independent variables of current ratio, debt equity ratio, total assets turnover, return on investment, sales growth, and price earnings ratio do not significantly influence the risk of stock investment. The findings suggest that accounting information has relatively little ability to explain variations in risk of stock investment. The validation of regression models shows no difference between the real investment risk and investment risk prediction, meaning that accounting information is useful for predicting the risk of stock investment.

  19. Kemampuan Ekstrak Daun Zodia (Evodia suaveolens) Sebagai Repellent Nyamuk Aedes aegypti Berdasarkan Lama Penggunaannya

    OpenAIRE

    Sianipar, Melati Agnes Anggreini

    2011-01-01

    Dengue Hemorrhagic Fever (DHF) disease is a contagious disease that caused by dengue virus and infected by Ae. aegypti. Since reported in 1968, this disease has become endemic and reported every year in Indonesia. One of the way to avoid it by using anti mosquitoes lotion which generally made by synthetic chemistry. Therefore, it necessary to find natural substance to avoid mosquitoes, one of the natural substances that can use is from zodia leaves (Evodia suaveolens) as repellent. The a...

  20. ANALISIS KUALITAS PELAYANAN PADA BAGIAN TATA USAHA BERDASARKAN TINGKAT KEPUASAN MAHASISWA

    Directory of Open Access Journals (Sweden)

    Muzakiyah Muzakiyah

    2011-12-01

    Full Text Available Kepuasan pelanggan merupakan hasil (outcome yang dirasakan atas penggunanya produk atau jasa, sama atau melebihi harapan yang diinginkan. Pelayanan di bagian Tata Usaha idealnya lebih bersahabat, cepat dan akurat. Ini berarti orientasi layanan di bagian Tata Usaha harus didasarkan pada kebutuhan mahasiswa. Dalam penelitian ini metode yang digunakan dengan menggunakan Pendekatan Lean ServPerf (Lean Service dan Service Performance. Service Performance digunakan untuk menganalisis tingkat instrumen kinerja pelayanan bagian Tata Usaha. Lean Service digunakan untuk menghilangkan waste aktivitas yang tidak bernilai tambah. Hasil dari penelitian ini, terdapat 14 atribut pelayanan yang perlu dilakukan perbaikan untuk meningkatkan kualitas pelayanan di bagian Tata Usaha Fakultas.

  1. Manfaat Informasi Akuntansi Untuk Memprediksi Risiko Investasi Saham Berdasarkan Pendekatan Decision Usefulness

    OpenAIRE

    Zarah Puspitaningtyas

    2010-01-01

    This study is to explain the usefulness of accounting information to predict the risk of stock investment based on the decision usefulness approach, technically shown through the effect of variable accounting on risk of stock investment. Based on analysis of 13 companies over a period of five years (2001-2005) by using multiple linear regression, the model shows that the current ratio significantly influence the risk of stock investment. However, signs of regression coefficients are not consi...

  2. ANALISIS TINGKAT KAPABILITAS SISTEM INFORMASI RUMAH SAKIT BERDASARKAN COBIT 5 (MEA01) PADA RSUD TUGUREJO SEMARANG

    OpenAIRE

    Ariel Bagus Nugroho; Amiq Fahmi

    2015-01-01

    RSUD Tugurejo Semarang merupakan Rumah Sakit kelas B milik pemerintah Provinsi Jawa Tengah yang menyediakan pelayanan jasa untuk masyarakat. Dalam manajemen pengolahan data, RSUD Tugurejo Semarang telah menggunakan sistem informasi rumah sakit. Untuk mengetahui apakah sistem informasi telah berjalan seperti yang diharapkan, maka perlu dilakukan analisis tatakelola teknologi informasi. Pada penelitian ini analisis tatakelola teknologi informasi berfokus pada proses pengawasan, evaluasi dan pen...

  3. Pola Spatial Persebaran Pusat Perbelanjaan Modern Di Surabaya Berdasarkan Probabilitas Kunjungan

    Directory of Open Access Journals (Sweden)

    Achmad Miftahur Rozak

    2013-09-01

    Full Text Available Surabaya sebagai kota besar saat ini  mulai dipenuhi dengan pusat perbelanjaan modern hingga mencapai lebih dari 20 unit. Perkembangannya saat ini menyebabkan  adanya persaingan antar pusat perbelanjaan satu dengan yang lain.  Dengan kondisi seperti ini, diperlukan identifikasi mengenai besaran nilai probabilitas masing-masing pusat perbelanjaan terhadap penduduk yang ada di Suarabaya. Dalam penelitian ini, penentuan probabilitas kunjungan didapatkan dari model Huff. Model ini menghitung nilai probabilitas penduduk yang ada terhadap pusat perbelanjaan dengan menggunakan variabel jarak dan luas bangunan total. Hasil perhitungan tersebut kemudian dikombinasikan dengan perkiraan jangkauan pelayanan tiap pusat perbelanjaan sehingga didapatkan tipologi kecamatan terhadap kemungkinan mengunjungi seluruh pusat perbelanjaan yang ada di Surabaya. Didapatkan bahwa terdapat empat kategori yang masing-masing memiliki karakteristik dan variabel yang mempengaruhinya. Kategori pertama merupakan 5 kecamatan dengan probabilitas rendah dan terjangkau dengan faktor yang berpengaruh adalah luas lantai bangunan serta jarak yang digambarkan oleh jangkauan pelayanan. Kategori kedua merupakan 22 kecamatan dengan probabilitas sedang dan terjangkau dengan faktor yang mempengaruhi adalah jangkauan pelayanan serta jarak terhadap masing-masing pusat perbelanjaan. Kategori tiga merupakan 2 kecamatan dengan probabilitas tinggi dan terjangkau dengan faktor yang berpengaruh adalah luas pusat perbelanjaan. Sedangkan kategori terakhir adalah 2 kecamatan dengan probabilitas sedang namun belum terjangkau oleh layanan pusat perbelanjaan

  4. DAYA SAING PT BENAR FLORA UTAMA BERDASARKAN AKTIVITAS RANTAI NILAI FLORIKULTURA

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    Ratih Marina Kurniaty

    2012-11-01

    Full Text Available ABSTRACTThe aims of this research were (1 to identify of the value chain that has been applied by the company, (2 to describe projections from internal and external condition as input in the company’s success factor analysis, (3 to determine the company’s strategic position, and (4 to formulate alternative strategies to increase the company’s competitiveness in  floriculture industry.  This research used SWOT analysis method by considering company’s position and value chain approach which was started with chain mapping to describe actors involved, what business issues in this company face and which activity has the greatest contribution. The value chain approach were also used to determine the prominent product based on the annual sales report. The research results indicated that the issues in the value chain include: expensive input prices, uncertainty in seed supply and higher transportation cost especially for Euro Country and America. Based on internal and external matrix, the company’s position is in the strategic growth quadrant, so the company can apply some alternative strategies such as  (1 maintaining good relationships with customers and suppliers, (2 expanding market to Asia, (3 upgrading the types of tree, (4 attending big exhibitions, (5 develop products by creating plants trendcentre, (6 enhancing the knowledge management for the company’s human resource, (7 production maximizing for the domestic market, (8 establishing distribution channels in each city, (9 setting a clear target market, (10 maintaining the quality of the plants, (11 restructuring the company in order to clarify the specialization of work, and (12 designing documents to better provide the seeds according to customers’ need.Keywords: competitiveness, floriculture industry, chain mapping, value chain economic analysis, SWOT analysisABSTRAKTujuan penelitian ini adalah (1 identifikasi rantai nilai yang telah diterapkan oleh perusahaan, (2 menggambarkan dari kondisi internal dan eksternal sebagai analisis faktor keberhasilan perusahaan, (3 posisi strategis perusahaan, dan (4 merumuskan strategi alternatif untuk meningkatkan daya saing dalam industri florikultura. Penelitian ini menggunakan metode analisis SWOT dengan mempertimbangkan posisi perusahaan dan pendekatan value chain dimulai dengan pemetaan rantai untuk menggambarkan siapa aktor yang terlibat, apa masalah bisnis di perusahaan ini dan aktivitas mana memiliki kontribusi terbesar. Pendekatan rantai nilai juga digunakan untuk menentukan produk terkemuka dari laporan penjualan tahunan. Hasil penelitian menunjukkan bahwa isu-isu dalam rantai nilai meliputi: harga input yang mahal, pasokan benih tidak menentu dan biaya transportasi terutama untuk Negara Eropa dan Amerika lebih tinggi. Hasil matriks internal dan eksternal, posisi perusahaan pada pertumbuhan strategis sehingga perusahaan menerapkan beberapa strategi. Strategi alternatif yang dapat ditingkatkan oleh perusahaan, seperti: (1 maintaning hubungan baik dengan pelanggan dan pemasok, (2 memperluas pasar ekspor ke Asia, (3 meningkatkan jenis pohon, (4 mengikuti pameran besar, (5 berinovasi produk ke membuat trendcentre tanaman, (6 peningkatan manajemen pengetahuan untuk sumber daya manusia di perusahaan, dan (7 memaksimalkan produksi untuk pasar domestik, (8 saluran distribusi yang didirikan di setiap kota, (9 membuat target pasar yang jelas, (10 mempertahankan kualitas tanaman, (11 merestrukturisasi perusahaan dalam rangka untuk memperjelas spesialisasi pekerjaan, (12 membuat dokumen menyediakan benih sesuai dengan kebutuhan pelanggan.Kata kunci: daya saing, industri florikultura, rantai pemetaan, analisis rantai nilai ekonomi, analisis SWOT

  5. Perkiraan Fatigue Life pada Bracket Kapal Tanker Berdasarkan Common Structural Rules

    Directory of Open Access Journals (Sweden)

    Dita septiana

    2012-09-01

    Full Text Available Umur kelelahan (fatigue life dari struktur kapal dianalisis dengan menggunakan standar pada Common Structural Rules for Double Hull Oil Tanker. Kapal tanker single hull direncanakan akan dikonversi menjadi FPSO sehingga perlu diketahui sisa fatigue life konstruksinya. Dalam penelitian ini, fokus analisis dilakukan pada konstruksi bracket karena bracket sebagai salah satu penopang yang esensial pada kapal ini. Oleh karena itu, perlu diketahui letak bracket dengan tegangan paling besar dan besar fatigue lifenya. Kapal tersebut dimodelkan menggunakan softwareMSC Pastran sebagai pre-processor dan MSC Nastran sebagai processor. Bagian kapal yang dimodelkan adalah 3 ruang muat pada midship. Ruang muat pada bagian tengah dari ketiga ruang muat tersebut adalah ruang muat yang paling besar. Fatigue life yang dianalisa merupakan pengaruh dari beban lingkungan (beban gelombang air laut dan beban internal (beban tangki. Kondisi pembebanan yang dilakukan ada 6 macam load cases sesuai dengan ketentuan CSR. Tegangan pada bracket yang didapat dari pemodelan diambil tegangan yang paling besar untuk dianalisa fatigue lifenya. Hasil perhitungan menunjukkan bahwa bracket dengan tegangan paling besar terjadi pada web frame 7 pada ruang muat tengah dan pada kondisi pembebanan A2 didapat umur kapal yang paling rendah yaitu sebesar 26 tahun.

  6. Kategorisasi dokumen web secara otomatis berdasarkan folksonomy menggunakan multinomial naive Bayes classifier

    OpenAIRE

    Irawan, Hendy

    2016-01-01

    Folksonomy is a non-hierarchical document categorizing system, that treats every category in a flat manner, dan every category is entered freely by anyone who submitted a document in these categories. Categorization is done automatically at the time a document is submitted, by entering the list of categories that best fit the document. del.icio.us (http://del.icio.us) site is one of the most popular social bookmarking sites that uses folksonomy. Usage of folksonomy, although very easy, also h...

  7. Nilai Kesukaan Konsumen Terhadap Teh Daun Gaharu (Aquilaria malaccensis Lamk.) Berdasarkan Letak Daun Pada Pohon

    OpenAIRE

    Adriana, Nora

    2015-01-01

    Agarwood is a product of Non-Timber Forest Products are of high value and are exported to foreign countries. Utilization of wood still focused on the use of agarwood trees, sap and skin is more often used as a distinctive aroma produced. Therefore, it is necessary to study on the effect of the aloe plant leaf lies on the characteristics of the value of consumer preferences in the tea leaves of the aloes that dihasilkan.Tujuan this study is to determine the level of preference for the public t...

  8. Nilai Kesukaan Konsumen Terhadap Teh Daun Gaharu (AquilariamalaccensisLamk) Berdasarkan Letak Daun Pada Pohon

    OpenAIRE

    Adriana, Nora

    2016-01-01

    Agarwood is a product of non-timber forest product are high value and are exported to foreign countries. Utilization of wood still focused on the use of agarwood tress, sap and skin is more often used as a distinctive aroma produced. Therefore, it is necessary to study on the effect of the aloe plant leaf leaves of that aloes. The purpose of this study is to determine the level of preference for the public to tea agarwood (A. malaccensis Lamk) based on the location of the leaves on the stem. ...

  9. Uji Antioksidan Daun Muda dan Daun Tua Gaharu (Aquilaria malaccensis Lamk) Berdasarkan Perbedaan Tempat Tumbuh Pohon

    OpenAIRE

    Harahap, Rizki Khadijah

    2016-01-01

    The leaf of aloe has an antiokxidant activity which can reduce free radicals. The research is done to know the class of chemical compounds and to know the effect of grown ground of Aloe toward chemical compund of fresh and rotten leaf, and its antioxidant activities. Ethanol extractr the leaf of Aloe by using maceration method, concentrated by rotary evaporator and evaporated by waterbath. The test of antioxidant activity use DPPH method 1,1 – diphenil-2-picrylhydrazil (DPPH), and an observed...

  10. Usulan Pemilihan Alternatif Tipe Crane Berdasarkan Faktor Biaya Dan Fisik Di Pt Pelindo I Belawan

    OpenAIRE

    Simarmata, Pandapotan

    2015-01-01

    PT Pelindo Belawan adalah perusahan yang bergerak di bidang jasa kepelabuhanan. Salah satu jasa yang ditawarkan oleh PT Pelindo Belawan adalah bidang bongkar muat barang. Departemen yang menangani kegiatan bongkar muat adalah Unit Bongkar Muat. Unit bongkar muat ini biasanya melakukan kegiatan bongkar muat untuk barang curah baik curah kering ataupun cair dan peti kemas. Muatan seperti curah kering menggunakan mobile crane sebagai alat bongkar muat. Kegiatan bongkar muat berlangsung mulai dar...

  11. ANALISIS INVESTASI PROYEK PEMBANGUNAN TERMINAL LIQUEFIED NATURAL GAS (LNG DI LABUAN MARINGGAI BERDASARKAN ANALISA BEBAN MODAL

    Directory of Open Access Journals (Sweden)

    Lebinner Sinaga

    2015-02-01

    Full Text Available Meningkatnya kebutuhan akan energi gas bumi tidak terlepas dari kondisi makro ekonomi di Indonesia. Dampak yang paling besar adalah dengan semakin berkembangnya sektor industri dalam negeri terutama di wilayah Jawa Barat dan Lampung, maka kebutuhan gas di wilayah ini meningkat untuk masa mendatang.Kondisi ini oleh PGN harus disikapi dengan serius dikarenakan kemampuan supply untuk gas saat ini tidak bisa untuk memenuhi kenaikan gas di masa mendatang yaitu sekitar 44% kenaikan kebutuhan gas. Saat ini PGN untuk wilayah Jawa Barat dan Lampung hanya mampu untuk mensupply sekitar 590 MMscfd, dengan target PGN untuk sepuluh tahun mendatang yaitu 1000 MMscfd, maka terjadi defisit supply gas sekitar 410 MMscfd. Dalam mencapai target supply gas yang telah ditetapkan yaitu 1000 Mmscfd dikarenakan terbatasnya pasokan gas dari sumber gas, maka PGN akan melakukan terobosan baru dengan keluar dari konsep supplay gas konvesional yakni dengan menggunakan gas alam cair atau Liquefied Natural Gas  (LNG. Dengan konsep ini, maka pasokan gas menjadi tidak terbatas, karena dapat didatangkan dari berbagai tempat ataupun dari negara lain. Dalam mendatangkan gas alam cair ini, dibutuhkan suatu stasiun penerima gas yang biasa disebut LNG Receiving yang penempatannya dengan berbagai pertimbangan dipilih di darat (onshore. Pembangunan terminal LNG ini sangat dibutuhkan untuk meningkatkan supply gas PGN. Pembangunan terminal LNG ini diperlukan satu arahan secara economical value. Dengan menggunakan metode Nilai Sekarang Bersih (NSB, Nilai Tahunan Bersih (NTB, dan Tingkat Pengembalian Internal (IRR maka proyek Pembangunan Terminal LNG ini layak untuk dilaksanakan.

  12. KUALITAS DATA IMUNISASI RUTIN BERDASARKAN METODE DATA QUALITY SELF ASSESSMENT (DQS

    Directory of Open Access Journals (Sweden)

    Ingan Tarigan

    2012-09-01

    Full Text Available Reporting and Recording System on immunization in Indonesia have been faced with many difficulties. Data quality and accuracy are the main problem that can be found in Puskesmas, District Health Office and also in Provincial Health Office. Usually, Health information system is limited on data collecting activity but not following by analyzing it. Therefore, this current system can't support/provide valuable (immunization information as needed by the stakeholders. This research was conducted in 3 provinces in Indonesia. Selected study areas were Lampung province (Metro city and Lampung Selatan district; West Java Province (Bogor city and Garut district, East Nusa Tenggara Province (Kupang city and Belu district. The objectives of this study were to assess the quality of recording and reporting system of immunization based on the DQS method Study design was cross-sectional. Assessment was carried out with Data Quality Self-Assessment (DQS method, using qualitative design by conducting interview and observation. Data quality of Immunization program was divided into 5 groups: recording, reporting, demography/denominator, availability of form, and data utilization. The assessment on DQS method showed that not all immunization services was reported by heath providers; data processed manually; archiving system was not well managed; lack of provided forms for recording and reporting forms; data was not reported in time; set up the immunization target was not standardized among areas (for every administrative levels; monitoring was  not conducted optimum to evaluate the performance of immunization program; and capacity building on human resources was urgently needed to improve the quality of immunization program.  Keywords: Immunization, Quality, DQS Method

  13. POLA PENYAKIT SEBAB KEMATIAN DI JAWA - BALI BERDASARKAN SURVEI KESEHATAN RUMAH TANGGA 1995

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    Sarimawar Djaja

    2012-09-01

    Full Text Available In Indonesia, the National Household Health Survey (SKRT is still the main source of information on causes of death, which is now integrated with the National Socio Economic Survey (Susenas. The SKRT uses technique of verbal autopsy with open questions then classifies the diseases using ICD 10. There were 1719 cases obtained with 97,8% response rate of deaths reported by Susenas to the SKRT. Eventhough there are some limitations, the 1995 SKRT using proportion analysis is able to show the pattern of cause of death. The pattern in Java-Bali shows the current trend of epidemiologic transition - the changing pattern of infectious diseases towards degenerative diseases. For the first time the 1995 SKRT reveals the replacement of dominant infectious diseases by circulatory (cardio as well as cerebrovascular diseases. The SKRT observation in the period of 1980 -1995 shows that the transition has happened with rapid trend compared to the England and Wales experience. Yet infectious diseases are still the important cause of death particularly among young age groups and population in the rural areas. Circulatory diseases do not affect only the old age groups but the productive age groups as well. The circulatory diseases can not be disregarded in the rural areas. This condition affects both sexes male and female. Maternal together with perinatal diseases are still quite substantial causes of death.

  14. Pengembangan Tungku Gasifikasi Arang Biomassa Tipe Natural Draft Gasification Berdasarkan Analisis Computational Fluid Dynamics (CFD

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    Erlanda Augupta Pane

    2014-10-01

    Full Text Available A biomass stove based on natural draft gasification (NDG has been developed in a previous study (Nelwa, et al. 2013 by using simulation based on heat transfer and equilibrium modeling. In this study, a CFD simulation was performed in order to analyze the effect of chimney height, and inlet hole diameter of the stove to the performance of the stove. The results of simulation showed that power produced by stove was between 1863.9 J/s until 2585.7 J/s, and its gasification efficiency was 67.11%. The results of simulation also showed that charcoal gasification produces combustible gases (CO, CH4, and H2 at the bottom and the center of stove, and then they were oxidized by secondary air at the top of stove. This oxidation reaction produces sufficient heat energy which can be used for cooking process.

  15. Analisa Layout Surat Kabar Berdasarkan Prinsip-Prinsip Desain Melalui Metode Estetika Birkhoff

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    Arik Kurnianto

    2013-09-01

    Full Text Available This study has primary focus to analyze the aesthetic layout of a newspaper with a mathematical approach, which refers to some methods of Birkhoffs aesthetic measurement developed by David Ngo Chek Ling, et.al. Ngo developed a method of measuring the aesthetic layout that can be used for various design purposes, especially for a computer interface design. Measurement method that he developed refers to the principles of design aesthetics, such as: the principle of balance, the principle of sequence, the principle of unity, and the principle of equilibrium. Birkhoff aesthetic measurement method was used as final analysis to determine the value of aesthetic layout. In this study, some national and local media were selected as samples to determine and assess the aesthetic layout. Based on data analysis, Birkhoff aesthetic measurement method can be applied to measure the aesthetic value of the newspaper layout mathematically.

  16. EVALUASI SISTEM INFORMASI KENDARAAN (GFSERVICE)- BINUS UNIVERSITY BERDASARKAN KERANGKA COBIT PADA DOMAIN DELIVERY AND SUPPORT

    OpenAIRE

    Tangkas Udiono; Haris Setia Budi; Mariyani

    2015-01-01

    Information Systems Audit is an activity that is carried out in a company that aims to ensure compliance with existing policies. General Services is one of the units in BINUS University whose activities in the form of services such as Transportation and Document Courier, Copy Centre and General Facility. However, this study is limited to the Transportation and Document Courier unit that uses an online reservation application gfservice.binus.ac.id. Maturity level of the existing information sy...

  17. Sebaran Lokasi Penanaman Bawang Merah Lokal Samosir Berdasarkan Ketinggian Tempat Di Daerah Tangkapan Air Danau Toba

    OpenAIRE

    Hutapea, Rose Friska

    2016-01-01

    This research aims to determine the location planting distribution of Samosir’s local onion based on altitude in Watershed of Lake Toba. This research was conducted in the central region of onion planting around of Lake Toba which have at altitude 900 – 2000 meters above sea level. This research used survey methods which includes literature studies, preparation of the questionnaire, the determination of research location, location mapping for the research, survey around of Lake Toba and proc...

  18. Studi Perancangan Bangunan Amaliun Food Court Ditinjau Berdasarkan Kinerja Aspek Fungsional

    OpenAIRE

    Ritonga, Isniar Tiurma Leonora

    2016-01-01

    Architectural Design always attempt to provide the building withperformance (efficiency and effectiveness) which has physically comfort in carrying out any activities. The capacity to accommodating the activites is one of the building functional aspects. Consequently, when the planned buildings inhabited, they are usually developed to become functional aspects. This condition becomes the challenge for building in maintainingtheir performance. The implementation of performanc...

  19. ANALISIS TINGKAT KAPABILITAS SISTEM INFORMASI RUMAH SAKIT BERDASARKAN COBIT 5 (MEA01 PADA RSUD TUGUREJO SEMARANG

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    Ariel Bagus Nugroho

    2015-11-01

    Full Text Available RSUD Tugurejo Semarang merupakan Rumah Sakit kelas B milik pemerintah Provinsi Jawa Tengah yang menyediakan pelayanan jasa untuk masyarakat. Dalam manajemen pengolahan data, RSUD Tugurejo Semarang telah menggunakan sistem informasi rumah sakit. Untuk mengetahui apakah sistem informasi telah berjalan seperti yang diharapkan, maka perlu dilakukan analisis tatakelola teknologi informasi. Pada penelitian ini analisis tatakelola teknologi informasi berfokus pada proses pengawasan, evaluasi dan penilaian kinerja, dan kesesuaian kinerja teknologi informasi, yaitu domain MEA01 pada framework COBIT 5.Tujuan penelitian ini untuk mengetahui tingkat kapabilitas dan strategi perbaikan untuk proses pengawasan, evaluasi dan penilaian kinerja dan kesesuaian TI. Metode pengumpulan  data penelitian ini dengan menggunakan studi dokumen, kuesioner dan wawancara kemudian dianalisis tingkat kapabilitas dan kesenjangan. Tingkat kapabilitas yang didapat dari hasil penelitian yaitu berada level 2 (managed. Untuk menaikkan tingkat kapabilitas pada level 3 maka maka perlu dilakukan secara bertahap strategi perbaikan pada PA 2.1, PA2.2, PA 3.1, dan 3.2. Kata kunci: Analisis Tata Kelola TI, COBIT 5, MEA01, Tingkat Kapabilitas, Rumah Sakit.

  20. Pendugaan Umur Simpan Kerupuk Bawang Kentang Dengan Metode Akselerasi Berdasarkan Pendekatan Kadar Air Kritis

    OpenAIRE

    Murni, Asri

    2016-01-01

    The aim of this research was to find the effect of several types of packaging and storage time of the onion potato chips, and to estimate the shelf life of onion potato chips which were packed in polypropylene, polyethylene, and metalized plastic using accelerated method based on the critical moisture content approach. The effect of the types of packaging and storage time of the onion potato chips was determined using a completely randomized design with two factors,i.e.packaging type (K) (pol...

  1. Penskalaan Butir Format Respons Pilihan dan Respons Bebas Berdasarkan Model Rasch dan Partial Credit

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    Eko Hariadi

    2007-06-01

    Full Text Available Penelitian melihat pengaruh jumlah parameter butir, kategori respons bebas (RB, pengaruh sampel terhadap akurasi estimasi parameter kemampuan untuk menghasilkan estimasi yang stabil dan pengaruh pembobotan butir RP dan butir RB terhadap kesalahan baku. Penelitian dalam dua tahap, simulasi menggunakan 30 kondisi dengan replikasi 50 dengan variabel panjang tes, jumlah kategori, dan jumlah parameter butir, dan analisis deskriptif, dilanjutkan penerapan penskalaan gabungan butir tipe respons pilihan (rp dan butir respons bebas (rb pada konstruksi tes elektronika yang terdiri 40 butir pilihan ganda dan 4 butir jawaban tersusun, 3 butir memiliki lima kategori jawaban dan 1 butir dengan 4 kategori jawaban, melibatkan 355 siswa. Hasil penelitian menunjukkan: ukuran sampel kurang berpengaruh pada root mean square error atau (RSME> dan korelasi antara 9 dengan 0, namun berpengaruh terhadap akurasi estimasi parameter butir pilihan ganda (/>/y,dan parameter butir respons tersusun (3^- Jumlah parameter butir berpengaruh terhadap parameter kemampuan, tetapi tidak berpengaruh terhadap akurasi dari b^, dan S„,. Estimasi dari parameter tingkat kesulitan butir jawaban tersusun tiga kategori lebih akurat daripada butir jawaban tersusun lima kategori. Estimasi tahan {robust untuk parameter kesulitan butir jawaban tersusun 5 kategori memerlukan sampel minimal 250 responden, sedangkan untuk butir respons tersusun 3 kategori memerlukan sampel minimal 100 responden. Estimasi parameter kemampuan dari skor total (0^^ tidak sama dengan rata-rata jumlah tbeta dari masing-masing subtes (0^ + 0CR. Theta dari tes yang dikalibrasi bersama-sama berbeda dengan theta dari total subtes yang dikalibrasi secara terpisah. Korelasi kemampuan yang mengunakan pembobotan dan kemampuan tanpa pembobotan mempunyai suatu rentang dari 0,988 sampai 0,948. Kata kunci: penyekaiaan, model rash dan partial credit.

  2. Penetapan Kadar Asam Lemak Bebas Pada Minyak Kelapa Sawit (Crude Palm Oil) Berdasarkan Standar Nasional Indonesia

    OpenAIRE

    Lestari, Melya

    2011-01-01

    Tanaman kelapa sawit (Elaeis guinensis JACQ) adalah tanaman berkeping satu yang termasuk dalam famili Arecaceae. Nama genus Elaies berasal dari bahasa Elaion atau minyak, sedangkan nama spesies Guinensis berasal dari kata Guinea, yaitu tempat di mana seorang ahli bernama Jacquin menemukan kelapa sawit pertama kali di pantai Guinea (Ketaren,1986). Kelapa sawit dapat tumbuh dengan baik pada daerah beriklim tropis dengan curah hujan 2000 mm/tahun dan kisaran suhu 22º - 32ºC. Warna daging buah ia...

  3. Gambaran Efektivitas Kepemimpinan Bina Nusantara Computer Club Kepengurusan Ke-22 Berdasarkan Fiedlers Contingency Model

    OpenAIRE

    Eleonora Francisca Maria Sumual; Juliana Lee

    2011-01-01

    Fiedler has theory which is called contingency model. According to him, if an organization attempts to achieve group effectiveness through leadership, then there is a need to assess the leader according to an underlying trait, assess the situation faced by the leader, and construct a proper match between the two. With Fiedler model, researchers were doing assessment to one of the student organization in Bina Nusantara University, which is BNCC 22nd student committee. The result of the researc...

  4. Gambaran Efektivitas Kepemimpinan Bina Nusantara Computer Club Kepengurusan Ke-22 Berdasarkan Fiedlers Contingency Model

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    Eleonora Francisca Maria Sumual

    2011-03-01

    Full Text Available Fiedler has theory which is called contingency model. According to him, if an organization attempts to achieve group effectiveness through leadership, then there is a need to assess the leader according to an underlying trait, assess the situation faced by the leader, and construct a proper match between the two. With Fiedler model, researchers were doing assessment to one of the student organization in Bina Nusantara University, which is BNCC 22nd student committee. The result of the research is that student organization in this case two committees from BNCC show two different results. The first one does not fit with Fiedler model, which is the people oriented leader can make an effective leadership, and the second one with people oriented leader seems not effective to lead the committee with more old member of the organization.

  5. Perbedaan kualitas hidup anak penderita penyakit ginjal kronis berdasarkan stadium penyakit ginjal kronis

    OpenAIRE

    Nadeak, Dicky Iskandar

    2014-01-01

    Background Chronic kidney disease (CKD) is a condition whereas kidney damage occurs at least 3 months with or without decrease of glomerular filtration rate or glomerular filtration rate less than 60mL/minute/1.73m¬2. Assessment quality of life is important in children with CKD cause it can influence physical growth, developmental retardation, cognitive impairment, academic imparment, emotional disorders and social relationships Objective To assess quality of life in children based on stag...

  6. Analisis Keanekaragaman Genetik dan Diferensiasi Jati Jawa dan Madura berdasarkan Marka Mikrosatelit untuk Mendukung Fingerprinting Jati

    OpenAIRE

    Munisyatul Millah; Noor Aini Habibah; Endah Suwarni

    2010-01-01

    Analysis fingerprinting teak is supported by information about teak’s character molecularly. The information is gotten by analyzing 3 primary microsatellite in 46 teak samples that produce total 18 kinds of alel averagely 6 alel per locus. Genetics variety level is shown by Observed Heterozigosity (Ho), Expected Heterozygosity (He), Polimorfi sm Information Content (PIC) and Genetics Differentiation Coeffi cient successively 0.5122; 0.6221; 0.5818; and 0.0629. Kinship connection through den...

  7. KARAKTERISASI DAN JARAK KEMIRIPAN UWI (Dioscorea alata L. BERDASARKAN PENANDA MORFOLOGI UMBI

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    Trimanto Trimanto

    2012-01-01

    Full Text Available Yam (Dioscorea alata L. is a potential local crop for supporting food security program in Indonesia.  Inventory and characterization of yam have been conducted in scattered population at Nganjuk region - East Java.  The research was aimed to identify the characteristic of Nganjuk’s yam, based on the tuber morphology and to determine its similarity distance value.  The characterisation were analyzed using interval similarity function, based on NTSys DICE coefficient programme. The result showed that 22 accession numbers which comprises of 13 variants of yam were found in Nganjuk region. The same variants of yams indicated by their close similarity distance although they were originated from different areas.

  8. PERENCANAAN TARIF IDEAL PENGIRIMAN BARANG BERDASARKAN METODE PERHITUNGAN BIAYA OPERASIONAL KENDARAAN (BOK

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    Erna Mulyati

    2013-12-01

    Full Text Available PT Syncrum Logistics is a company engaged in the expedition of freight transportation services 3PL (Third Party Logistics, which delivery goods from one place to the destination area by land (On Road by using a fleet of wings box trucks. PT Syncrum Logistics has more than 80 wings box fleet which are owned by the box itself. One is a box type truck wings are often used for service delivery to Milkrun Cibitung. On the imposition of tariffs for one-time delivery of goods on the route there is a difference with Milkrun Cibitung previous rate calculation that originally was Rp 800.802, - to be decreased to Rp 522.700,-. Tariff of Rp 522.700 based solely on the price offer made by the customer on the marketing side. That price has not reached the ideal rate of the company. From the description above, the calculation for ideal freight rates by route Milkrun Cibitung uses the Vehicle Operating Costs. Calculating the Vehicle Operating Costs must first determine the fixed costs, variable costs and the determination of the basic rate and calculation of the costs incurred each year, month and day, and the benefits to be achieved by the company. Difference obtained is Rp 229.837,- from the initial rate off price minimum negotiable to do between Rp 800.802 to Rp. 707.612/28 pallets (Full Load.

  9. Identifikasi Kelelawar Pemakan Buah Asal Sulawesi Berdasarkan Morfometri (THE MORPHOMETRIC IDENTIFICATION OF CELEBES FRUIT BATS)

    OpenAIRE

    Tiltje Andretha Ransaleleh; Rarah Ratih Adjie Maheswari; Purwantiningsih Sugita; Wasmen Manalu

    2013-01-01

    The bat is very important for human life, because of their  role as pollinator of plants, as a producer oforganic fertilizer,  and as food.  In Northern Celebes fruit eating bats serve as exotic food, so the presenceof bats were threatened to be extinct due to uncontrolled hunting.  The changes of the forest for plantationlands, damage the habitats and the bats were forced to migrate out.   The aim of the study was to identifythe fruit eating bats of Celebes.  Morphometry of body size, skull,...

  10. PENGELOMPOKAN BERBAGAI MERK MI INSTAN BERDASARKAN KEMIRIPAN KANDUNGAN GIZI DENGAN MENGGUNAKAN ANALISIS BIPLOT

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    AGUSTINUS ANGELAUS ETE

    2014-08-01

    Full Text Available At this time, almost everyone once to consume instant noodles. The high interest of public on the instant noodles should be balanced with enough knowledge about the noodles and its nutritional content, either on it’s instant noodles which have similar nutrient content and nutrient content that become identifier of each this group of noodles. The method can be used to obtain information on several brands of instant noodles that have similar nutrient content and nutrient content type that become identifier of each group of instant noodles is biplot analysis. Biplot analysis can show mie and nutrient content types simultaneously in a two-dimension plot. So that from a plot shows noodles and nutritional content types simultaneously, so that obtain information about the instant noodle that have similar nutrient content and nutrient content types into identifier of each group of instant noodles. This study was used 33 brands of instant noodles as observed objects with the type of nutrient content were observed there were nine. This study aims to find out some instant noodles that have similar nutrient content and nutrient content type that become identifier of each group of instant noodles. From the biplot analysis, obtained six groups of instant noodles with different identifier variables.

  11. Identifikasi longsoran bawah laut berdasarkan penafsiran seismik pantul di perairan Flores

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    Kris Budiono

    2014-06-01

    Full Text Available http://dx.doi.org/10.17014/ijog.vol4no1.20092Submarine sliding frequently cause tsunami or a high velocity big wave around the submarine slid- ing area which enable to reach a long distance. This sliding is not always as a causal factor for hazard and even associate with storm and earthquake. Some of them occur in a narrow area and it’s just formed due to gravitational movement. Different with mechanism of landslide, which is commonly due to water saturated soil, the submarine sliding is a more complex event. The submarine sliding is an important natural process which causes a big volume of sediment mass moves from a shallow area to a much deeper area of seafloor. There are many types and causal factors of seafloor instability, but the sliding terminology is predominantly used for the phenomena. A variety of seafloor materials, environments and sediment masses are some extreme influential factors in creat- ing the types of submarine sliding. The reflector of seismics is usefull to interpret the indications of the occurrence of geological structure and sub-marine slumping In case of the Flores Sea, earthquake is a major causal factor for creating submarine sliding. The bigger magnitude of earthquake, the greater the dimension of submarine sliding. Eventually, it may affect to the more possible occurrence of a potential hazardous tsunami.  

  12. Tinjauan Yuridis Tentang Perjanjian Kredit Sindikasi Berdasarkan Hukum Kontrak (Study Kasus PT. Bank Sumut)

    OpenAIRE

    Harahap, Mulia Pandapotan

    2012-01-01

    Banking is one of the financial institutions which influence the economic development of a country. The role of a Bank as a financial institution in improving the development becomes important. From this point of view, it is obvious that a bank functions as “financial intermediary” with its main attempt is gathering and distributing funds to the public, and providing services in transferring payment. There are various kinds of loan granting by the Bank. Granting loan is, of cou...

  13. EVALUASI EMERGENCY RESPONS PLAN PADA KAPAL 42M CREW BOAT BERDASARKAN IMO INTERIM GUIDILINES

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    Mochamad Luqman Ashari

    2013-10-01

    Full Text Available Emergency situations that have tendency or potential harm can be happened any time and any where and carry some big damaging impacts to property damages, mental disturbances, injured and died victims. In shipping, emergencies can be happened in both at anchor or while doing loading and unloading activities at the port. The type of equipments used in emergency situations set out in SOLAS Chapter III (Life Saving Appliance and the guidelines for evacuation analysis on passenger ships refer to the IMO Guidelines Interm MSC/Circ.909. This study aimed to determine the muster station and evacuation time on the ship 42 M crewboats with a capacity of 101passengers. This ship consists of three parts of decks, these are lower part, main deck and bridge deck. The results showed that the placement of muster station is on the bridge deck with required wide 35.35 m2. Evacuation time need by the all passengers to reach the muster station on the bridge deck is 51.59 minutes, and this is in accordance with standard evacuation time (not more than 60 minutes.

  14. KARAKTERISASI DAN JARAK KEMIRIPAN UWI (Dioscorea alata L.) BERDASARKAN PENANDA MORFOLOGI UMBI

    OpenAIRE

    Trimanto Trimanto

    2012-01-01

    Yam (Dioscorea alata L.) is a potential local crop for supporting food security program in Indonesia.  Inventory and characterization of yam have been conducted in scattered population at Nganjuk region - East Java.  The research was aimed to identify the characteristic of Nganjuk’s yam, based on the tuber morphology and to determine its similarity distance value.  The characterisation were analyzed using interval similarity function, based on NTSys DICE coefficient programme. The result show...

  15. MODEL PREDIKSI KEJADIAN DEMAM BERDARAH DENGUE (DBD BERDASARKAN FAKTOR IKLIM DI KOTA BOGOR, JAWA BARAT

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    Jusniar Ariati

    2015-01-01

    Full Text Available AbstractDengue Hemorrhagic Fever (DHF presents a serious health problem in Indonesia. Dengue viruses are transmitted to human through the biting of infected mosquitoes, especially Aedes aegypti and Ae. albopictus.The occurrence of variation and climate change will Affect the growth areas of mosquitoes. This situation can influence on the emergence of dengue fever cases. In this paper will discuss the predictions of the mathematical model of considering the incidence of DHF with climatic factors. The research design was a retrospective study with the data collected is dengue incidence and climate include temperature, rainfall, humidity and rainy days since 2002-2010. Data analysis was performed using Minitab 16.0 software statistical time series. The results showed that R2 varied between 0.65 to 0.99. The highest R2 value of the regression equation obtained in August, September and October is 0.99 and the lowest in April with a R2 value of 0.65. The results of predictions based on 4 predictors (precipitation, rainy days, temperature and humidity with the incidence of DHF is actually not much different, except in April. It can be concluded that according to linear predictive models of dengue is influenced by climatic factors (precipitation, rainy days, temperature and humidity 2 months before and 1 month prior dengue incidence.Keywords : Dhf, Climate, Prediction ModelAbstrakDemam Berdarah Dengue (DBD merupakan salah satu masalah kesehatan di Indonesia. Aedes aegyptisebagai vektor utama penyakit DD/DBD kehidupannya dipengaruhi oleh faktor iklim, diantaranya suhu, kelembaban udara, curah hujan dan hari hujan. Berbagai upaya pengendalian  telah   dilakukan  namun  belum   menurunkan  jumlah  kasus  secara  signifikan, sehingga diperlukan model untuk memprediksi kejadian DBD di suatu wilayah sehingga kejadiannya dapat diantisipasi. Dalam tulisan ini akan membahas model matematika prediksi kejadian DBD dengan mempertimbangkan faktor iklim. Disain penelitian adalah studi retrospektif dengan data yang dikumpulkan adalah kejadian DBD dan iklim yang meliputi suhu, curah hujan, hari hujan dan kelembaban sejak tahun 2002-2010. Analisis data dilakukan secara time series menggunakan minitab statistical software 16.0. Hasil analisis mendapatkan model prediksi kejadian DBD dipengaruhi oleh fungsi empat faktor iklim, yaitu curah hujan, hari hujan, suhu dan kelembaban pada lag time2.Kata kunci : Demam Berdarah, Faktor Iklim, Model Prediksi

  16. Kecemasan Menghadapi Assessment Centre Berdasarkan Kepribadian Big Five dan Persepsi Dukungan Organisasi

    OpenAIRE

    Sulistyawati, Endang

    2015-01-01

    In the era of globalization, the role of human resources is increasingly important in achieving organizational goals. Assessment centre in human resources management is one of the methods of evaluation and selection in the promotion of employees. Evaluation process in assessment center process, may lead anxiety for employees. The level of anxiety is influenced by personality and perceived organizational support. The purpose of this study was to determine the relation between big five personal...

  17. penentuan kualitas batubara berdasarkan log gamma ray, log densitas dan analisis parameter kimia

    OpenAIRE

    afriani, yulia

    2015-01-01

    The research has been carried to determine coal quality at coal mine pit 2a South Block Lamin Project PT Mega Alam Sejahtera Berau East Borneo. The method that used in this research is well logging namely gamma ray log and density log to determine subsurface profile with 13 drilling point. From results of the analysis and interpretation of data obtained by the value of the average density is 1.63 g / cc, shale volume average of 0.2%, The average of ash conten 6:46%, average calorie of 5103.5...

  18. Proses Kliring Berdasarkan Warkat Pada Bank Mandiri Cabang Medan Imam Bonjol

    OpenAIRE

    Gultom, Novita Grezsia

    2014-01-01

    Kliring dilaksanakan di Bank Indonesia (BI) dengan menggunakan SKN (Sistem Kliring Nasional), dimana sistem ini baru diterapkan yang dimana sebelum menggunakan sistem SKN Kliring dilaksanakan dengan menggunakan SOKL (Sitem Otomasi Kliring Lokal). Pada daerah didalam wilayah Indonesia yang tidak ada Bank Indonesia maka proses Kliring dilakukan oleh salah satu Bank yang ditunjuk oleh Bank Indonesia pada daerah tersebut sehingga selain berfungsi sebagai Bank Umum yang melayani nasabah, maka Bank...

  19. KERAGAMAN DAN ANALISIS KEKERABATAN Hoya spp. BERTIPE DAUN NON SUKULEN BERDASARKAN KARAKTER ANATOMI DAUN

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    Aldi Rahman Hakim

    2013-01-01

    Full Text Available Hoya spp. (Apocynaceae: Asclepiadoideae has differences in leaf type, there are succulent and non succulent leaf types.  Anatomical structure of Hoya spp. leaf has not been widely studied, especially for the non succulent type. The aims of this research were to explore the diversity and relationship of non succulent Hoya, based on leaf anatomical characters represented by eight species i.e. H. bandaensis, H. campanulata, H. chlorantha, H. cilliata, H. coriacea, H. coronaria, H. densifolia and H. multiflora. Hoya leaf anatomical characters were observed on the paradermal and transversal section and analyzed by using IBM SPSS version 19 sotfware for cluster analysis. According to the paradermal observation, stomata were present at lower surface (hypostomatic for all species, and amphistomatic (both surface for H. densifolia.  The type of stomata is cyclocytic for all species. Clustered stomata were found in H. coriacea.  Observation on transversal section showed that all of species has the normal structure i.e cuticula, upper and lower epidermis, palisade parenchyma and spongy parenchyma with the variation in the layer thickness.  The cluster analysis resulted four groups at distance scale 19. Each group has specific characters. The first group has trichomes on both sides of the leaf surface. The second group has amphistomatic stomatal. The third group has thin leaves. The fourth group has the widest stomata.

  20. KEANEKARAGAMAN DURIAN (Durio zibethinus Murr. DI PULAU BENGKALIS BERDASARKAN KARAKTER MORFOLOGI

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    Sri Lestari

    2011-07-01

    Full Text Available Bengkalis Island is one of the areas with high diversity of durian (Durio zibethinus Murr.. This research was aimed to analyze the diversity of  durian cultivars of Bengkalis Island. It was conducted from April up to August 2010. The morphological data were analysed using NTSYS-pc 2.02 and minitab 14.13 softwares. Genetic similarity value among 36 accesions ranged from 0,28 (between BT 14, BT 15 and SB6 to 0,66 (between BT6 and BT7. The cluster analysis showed that durian diversity from Bengkalis island was 34-58% or had similarity level 42-66% and formed 7 main groups. However, they were ungroupped depend on their growth areas. Based on PCA (Principal Components Analysis value, durian diversity was 99,7% and formed 6 groups.  Furthermore, the result of pearson correlation analysis among 77 character showed that 10 characters were positively correlated and 4 characters were negatively correlated.

  1. Keragaman Genetik Tiga Populasi Kelapa Sawit (Elaeis guinensis Jacq.) Tipe Pisifera Berdasarkan Marka RAPD

    OpenAIRE

    Prayogi, Heru

    2015-01-01

    Palm oil as a plant producing oil is one of the primadonna oil palm plantations that become a source of producer non-migas for Indonesia foreign exchange. Superior varieties of palm oil produced by various research institutions that is a hybrid is tenera dura x pisifera (DxP). Pisifera having an important function in the production of seed oil palm. Hence the population pisifera very important to be managed and developed . A method of RAPD is a method to identify a number of large polymorphis...

  2. Desain Routing Information Protocol pada Jaringan Kamputer dengan Pengalokasian Jumlah Host Per Jaringan Berdasarkan VLSM

    OpenAIRE

    Lubis, Mhd Abdi Wahyuda

    2015-01-01

    The allocation of IP addresses is fundamental in building a computer network. In order for IP address allocation can be efficiently applied to each device connected to a network, first we should calculate the block of IP addresses available. On the other hand the process of routing in the network also requires efficient allocation of IP addresses. To help determining the allocation of IP address and routing path, an application as alternative solution is required. This study uses the Routing ...

  3. POLA ENDAPAN MINERAL DAN UNSUR LOGAM BATUAN DI DAS JENEBERANG BERDASARKAN DATA XRF, XRD DAN AAS

    OpenAIRE

    Muhammad Altin Massinai; Lantu; Makhrani; Maria

    2014-01-01

    Sungai Jeneberang merupakan aliran letusan gunungapi Lompobattang. Erupsi tersebut mengendapkan mineral-mineral di sepanjang aliran sungai Jeneberang, baik dari jenis logam maupun non logam. Indikasi mineralisasi di daerah DAS Jeneberang ditunjukkan dengan ditemukannya kekar-kekar yang berupa urat-urat (veins). Prospek akan mineralisasi ini juga ditunjang oleh struktur geologi yang termasuk cukup kompleks, karena Pulau Sulawesi merupakan pertemuan tiga lempeng bumi yakni Eurasia, Indo-Austra...

  4. Analisis Kandungan Klorin Pada Air Teh Celup Berdasarkan Suhu Dan Waktu Pencelupan Di Kota Medan 2013

    OpenAIRE

    Silaban, Saurma Erni Selvita

    2014-01-01

    Tea is the most consumed beverage either cold or hot. One kind of them is bag tea products. Tea bag is wrapped in smooth porous paper and heat resistant. In general, the paper uses chlorine as a bleach, it is the reason for necessary to study the chlorine content in water of tea bag. The purpose of this study was to determine the chlorine content in water of tea bag based on temperature and time. The kind of this study is descriptive survey. The object of study is the water of tea bag mixi...

  5. EVALUASI CEPAT DESAIN ELEMEN BALOK BETON BERTULANGAN TUNGGAL BERDASARKAN RASIO TULANGAN BALANCED

    Directory of Open Access Journals (Sweden)

    Agustinus Agus Setiawan

    2010-05-01

    Full Text Available Design procedure for reinforced concrete structure in Indonesia is provided by Tata Cara Perhitungan Struktur Beton, SNI 03-2847-2002. This code covers analysis method and basic assumptions that can be taken by a structural designer to design a reinforced concrete structure. An engineer has to design a flexural component, one of the structural component. One of the flexural component is beam element. SNI 03-2847-2002 adopt capacity design method in beam element design. This paper will be discuss a simple design procedure in beam element, based on ξ variable, which is ratio between ρ/ρb, with ρb is the balanced reinforcement ratio. The ξ value is limited to 0,75 maximum in SNI 03-2847-2002. A detail failure is guarantee in a beam element with ξ under 0,75. The analysis that have been done before, produce the correlation between Mn/bd2 and ξ, which can be a tool for design a beam element. A simple calculation use the table (Mn/bd2 vs ξ will be present at the end of this paper.

  6. STUDI PERILAKU KONSUMEN DAN IDENTIFIKASI PARAMETER BAKSO SAPI BERDASARKAN PREFERENSI KONSUMEN DI WILAYAH DKI JAKARTA

    Directory of Open Access Journals (Sweden)

    Ratna Yudtyhia Andayani 2

    2002-04-01

    Full Text Available Meat Ball is a very popular meat product in Indonesia, but there is still no quality standard of meat ball based on consumer preferences. The aim of the research was to identify consumer preferences of meat ball. This research was carried ont in three steps, which were consumer survey, sensory evaluation and physical and chemical analysis of meat ball. The results of consumer survey showed that the four factors that affect consumer preferences on meat ball (in priority order were quality, selling place, price and accessibility. The five quality characteristics of which affect consumer preferences (in priority order were taste, aroma, texture, color and size. The most favoured meat ball had moderate brothiness, light salt (salt content of 2 %, strong meat flavor with (meat content of + 45% boiled meat aroma; moderate tenderness (tenderness values of 0,90 kg/mm – 0,91 kg/mm and slight chewiness (chewiness value of 0,91 kg/mm; light grey color with L (lightness value of 53, 77, (a value of 3,77 and b value of 10,36 round form; medium size (diameters of 3-5 cm, amount to three to five meat ball per serving with reasonable price of Rp 2.000,- to Rp 3.000,- per serving.

  7. Penilaian Kinerja PT Bank X dalam Mengelola Asset dan Kewajiban Berdasarkan Analisis Resiko dan Analisis Return

    Directory of Open Access Journals (Sweden)

    Muhammad Yusuf

    2010-04-01

    Full Text Available Performance financial evaluation became a primary indicator for management, especially a bank. This research evaluated asset and liability management of PT Bank X to describe its risk and return, by using financial ratios. The results found that performance ratios of PT Bank X decreasingly, where interest margin and net margin decreased to negative. This because of interest expenses and other operational expenses increased. Risk evaluation based on liquidity ratio were also decreasing in 2006 2007, because of the most assets of the bank became illiquid assest and default credits. On the other hand, this conditions became worse because of Rush, many of their customers took their money out from the bank on the same period. In 2008, bank has reduced their default credits successively and made its liquidity better than previous year. Bad quality of credit management and control made the bank budgets their bad allowances for default credits higher and made banks capital risk higher too. Finally, all of banks capital was financed with their liabilities. The other hand, banks operating risk were recovered slowly, by organization rationalization to reduce number of employees, as efficiency also. But this effort, indeed, made employee expenses increasing because management must pay golden-shake hand costs to employees.

  8. Analisa Kuat Geser Balok Tinggi Beton Bertulang Berdasarkan Model Strut-And-Tie

    OpenAIRE

    Simamora, Vega Dinata P.

    2011-01-01

    Balok tinggi beton bertulang merupakan salah satu contoh daerah terganggu (Disturb Region) pada elemen struktur. Pada D-Region, teori balok (beam theory) tidak tepat diterapkan oleh karena itu diperlukan suatu metode yang rasional untuk diterapkan pada daerah-daerah tersebut. Strut-and-Tie Model (STM) merupakan pengembangan dari analogi rangka, telah diakui cukup baik diterapkan pada daerah-daerah tersebut. Pada penulisan skripsi ini metode Strut-and-Tie Model (STM) digunakan untuk memband...

  9. PENDETEKSIAN KEBERFUNGSIAN BUTIR PEMBEDA DENGAN INDEKS VOLUME SEDERHANA BERDASARKAN TEORI RESPONS BUTIR MULTIDIMENSI

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    Heri Retnawati

    2013-12-01

    Abstract The aim of the studi is to identify differential item fungtioning (DIF based on item response theory using bidimensional model. This study uses explorative quantitative approach. Data used in this study is a mathematics test of national exam 2003 data which has been proved to contain 2-dimensions (Badrun Kartowagiran & Heri Retnawati, 2007. The simple volume indices are used to detect DIF which is the development of the simple area indices. The testee are grouped based on their gender, groups of male students and female students. The item parameter estimation was performed with BILOG and TESTFACT, and then to estimate volume and draw the surface characteristics curve was conduct with MAPLE. The results showed that of the 28 items analyzed, 2 items potentially contained uniform DIF and 26 items potentially contained a non-uniform DIF.Keywords: unidimensional IRT, multidimensional IRT, DIF, UPD, SPD

  10. POLA KONSUMSI DAN PERMINTAAN PANGAN POKOK BERDASARKAN ANALISIS DATA SUSENAS 2005

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    Anna Vipta Resti Mauludyani

    2012-03-01

    Full Text Available 800x600 Normal 0 false false false IN X-NONE X-NONE MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Calibri","sans-serif"; mso-bidi-font-family:"Times New Roman";} Food demand can be found dynamic, altering by the change in price and income. How great the influence of those changes to food consumption is the important information as the basic consideration for government in creating policy related to food consumption. The objective of the research, which has survey design, was to analyze staple food consumption and demand pattern in household in Indonesia. The research was conducted in Bogor, from March to June 2008 by using secondary data Susenas year 2005 with 64.709 households as the samples. The staple food analyzed were rice, corn, cassava, sweet potato, wheat flour and its derived product (instant noodle, noodle. Data was processed by SAS program version 6.12 and Double-Log Regression econometrical model. Then, it was analyzed descriptively. Result shows that rice has the biggest expenditure proportion among staple food. Almost all staple food is obtained by purchasing, except in corn, cassava, and sweet potatoes. Energy contribution from rice reaches half of total energy consumption. The consumption of rice, corn, cassava, sweet potatoes, wheat flour and its derived product, instant noodle, and wheat noodle per capita per year are 100.52 kg, 3.36 kg, 11.67 kg, 4.10 kg, 5.09 kg, 3.39 kg, and 0.22 kg. Staple food which has consumption participation level almost 100% is rice. The own price elasticity of staple foods are not elastic, except in corn, wheat flour and its derived product. The income elasticity of all staple foods is not elastic in all category of region and income stratification. The demand elasticity of staple food give some implications on consumption and food consumption improvement, they are: 1 raising price of staple food can decrease consumption, thus, price stability is very important, 2 almost all staple foods has not elastic income elasticity, so that food consumption improvement needs great stimulus of increasing income, 3 poor household is greatly influenced by the increasing of price, thus, food consumption improvement for them must be conducted by doing many relevant efforts, 4 target of decreasing rice consumption is still cannot be reached, so that staple food diversification must be continuously developed, 5 in order to develop local food consumption, like corn, cassava, and sweet potato, the development of agro industry based on local food and Communication Information Education (CIE about food consumption diversification are essential to be conducted. Keywords: consumption and demand pattern, staple food, Susenas

  11. TANGGUNG JAWAB DIREKSI DALAM KEPAILITAN PERSEROAN TERBATAS BERDASARKAN UNDANG-UNDANG PERSEROAN TERBATAS

    OpenAIRE

    Kurniawan

    2012-01-01

    In running their duties, the board of directors are given rights and full authority to represent the company as long as they act in conformity to the corporation’s Article of Associations. The directors of a limited liability company have both internal and external responsibilities. Internal responsibility includes the Directors’ liability towards the Company and its Shareholders, meanwhile external responsibility covers the Directors’ liability towards third parties to whom the company owes ...

  12. KONSEP HAK SESEORANG ATAS TUBUH DALAM TRANSPLANTASI ORGAN BERDASARKAN NILAI KEMANUSIAAN

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    Hwian Christianto

    2011-02-01

    Full Text Available The idea of right to body autonomy grows more important as people are able to donate their organs. However, the two conceptions of rights currently applicable, i.e. ‘ownership’ and ‘possession’, are highly inappropriate to be applied to this case because human body is not a property. In this light, humanity purposes constitute stronger concept of bodyautonomy. Pemahaman akan hak atas tubuh menjadi semakin penting ketika seseorang dapat mendonorkan organ tubuhnya. Kedua konsep hak yang selama ini berlaku, yaitu konsep “ownership” dan “possession” ternyata jika diterapkan ke hak atas tubuh sangat tidak sesuai karena tubuh manusia bukanlah barang. Dalam kondisi inilah konsep hak dengan tujuan kemanusiaan memberikan dasar yang kuat tentang hak atas tubuh.

  13. KEDUDUKAN KETETAPAN MPR BERDASARKAN UU NO. 12 TAHUN 2011 TENTANG PEMBENTUKAN PERATURAN PERUNDANG-UNDANGAN

    Directory of Open Access Journals (Sweden)

    Delfina Gusman

    2012-03-01

    Full Text Available MPR Decree in resettlement of legislation under the Constitution of 1945 on the basis of Law No. 12 Year 2011 cocerning formation of legislation gives rise to a variety of polemics in the position of the MPR as State institutions. Provisions of the MPR is considered to have urgency in Indonesia's system, because the MPR as State institutions is considered to still have the duty and the authority of its strategic, e.g: inauguration of President and Vice President, the establishment of the Constitution. MPR also made provisions as one of basic national legislation program.

  14. Penciptaan Naskah Drama Ambu Hawuk Berdasarkan Tradisi Lisan dan Perspektif Jender

    Directory of Open Access Journals (Sweden)

    Budi Darma

    2013-11-01

    Full Text Available Artikel ini membahas proses penciptaan naskah drama Ambu Hawuk . Naskah ini diadaptasi dari cerita lisandan mitologi lokal yang berkembang di daerah Sunda. Cerita lisan dikumpulkan melalui wawancara mendalamdengan para informan yang mewakili berbagai versi. Setidaknya terdapat enam versi tradisi lisan mengenai tokohini, yaitu versi Cikawungading, Manonjaya, Cianjur, Sukaraja, Parungponteng, dan Galunggung. Dari keenamversi tersebut terdapat variasi dan kesamaan. Naskah ini mencoba membangkitkan kembali semangat feminismedalam peristiwa-peristiwa yang dijalin dalam legenda Ambu Hawuk. Sistem patriarki masyarakat Sunda lebih seringmemandang perempuan sebagai sebuah kaum yang memiliki keterbatasan dibandingkan dengan kaum laki-laki.Cerita ini menggambarkan seorang perempuan yang dianggap berada di belakang laki-laki dan menjadi bayangbayangseorang laki-laki, muncul menjadi seorang pemimpin.Kata kunci: Ambu Hawuk, naskah drama, tradisi lisan.ABSTRACTThe Creating Process of Drama Script Ambu Hawuk Based on the Oral Tradition and the GenderPerspective. This article discusses about the creating process of the drama script Ambu Hawuk. This script was adaptedfrom the oral story and the local mythology developed in Sunda. This oral story was compiled through the intensive interviewwith some sources of information that represented many kinds of versions. There are six versions of the oral traditiontalking about this character, namely: the version of Cikawungading, Manonjaya, Cianjur, Sukaraja, Parungponteng, and Galunggung. Of those six versions, there are varieties and similarities. This script tries to develop feminism spirit on someinterrelated events in Ambu Hawuk legend. From the perspective of Sundanese’ point of view on the patriarchy system, women are regarded as God’s creature who have more basic physical and mental limitations than men. This story describes a woman who is regarded as a person behind the man’s existence and becomes the man’s shadow; but soon afterwards, she becomes a leader.Keywords: Ambu Hawuk, Drama Script, Oral Tradition

  15. Kadar Karbon Bambu Parring (Gigantochloa atter)Berdasarkan Analisis Komponen Kimia

    OpenAIRE

    Sanusi, Djamal; Baharuddin; Putranto, Beta

    2013-01-01

    Penelitian ini dilakukan untuk mengetahui potensi bambu dan kemampuan hutan bambu menyerap karbon, membuat model pendugaan biomassa dan serapan CO2 tegakan bambu, serta menganalisis pola pengelolaan hutan bambu dalam optimalisasi pemanfaatan bambu. Metode yang digunakan adalah Interpretasi citra ALOS dan inventarisasi tegakan bamun untuk memperoleh luas hutan dan potemsi bambu. Penentuan biomassa dilakukan dengan metode destruktif dan pengukuran diameter dan tinggi untuk membuat model pendu...

  16. PEMBELAJARAN BERDASARKAN MASALAH MATERI GEOMETRI NON EUCLIDES UNTUK MELATIHKAN BERPIKIR KRITIS DAN KREATIF

    OpenAIRE

    Adamura, Fatriya; Masfingatin, Titin; Kirbiana, Elma Puspita

    2016-01-01

    Development and experiment research have been done because there is no learning tools ofproblem based learning. Development research was done by using modified 4-D model that consists of define, design, and develop. Research subject is student in Mathematics Education programme of IKIP PGRI Madiun even semester 2013/2014 that is learning Geometry System. Research instrument were validation sheet, reading validation sheet, learning management observation by lecturer sheet, student activity obs...

  17. STRUKTUR KONSEP MAHASISWA CALON GURU TENTANG MEDAN ELEKTROSTATIK BERDASARKAN ANALISIS FRAMING

    OpenAIRE

    S. E Nugroho; A. Setiawan; - Liliasari

    2012-01-01

    Penelitian ini bertujuan untuk mengeksplorasi struktur konsep mahasiswa calon guru tentang medan elektrostatik. Data diperolehdengan menggunakan metode thinks-aloud, didukung metode lain yaitu wawancara, diskusi, dan tes tertulis Responden penelitianterdiri atas delapan mahasiswa semester 2 yang telah menempuh fisika dasar sebagai kelompok I, dan sembilan mahasiswasemester 6 yang telah menempuh mata kuliah kelistrikan dan kemagnetan sebagai kelompok II. Mahasiswa tersebut diberipertanyaan rea...

  18. Kinerja Portofolio Saham Berdasarkan Strategi Investasi Momentum di Pasar Modal Indonesia

    OpenAIRE

    I Gst. Bgs. Wiksuana

    2009-01-01

    This research analyzes stock portfolio performance based on momentum investment strategy in Indonesian capital market. The sample consists of public companies listed in the Jakarta Stock Exchange that were actively traded between the periods of December 2001 until December 2007. Sampling method used in this research is multiphase sampling method which is analyzed by using abnormal return stock portfolio performance and means difference statistical test. The results of the analysis show that m...

  19. Penciptaan Naskah Drama Ambu Hawuk Berdasarkan Tradisi Lisan dan Perspektif Jender

    OpenAIRE

    Budi Darma

    2013-01-01

    Artikel ini membahas proses penciptaan naskah drama Ambu Hawuk . Naskah ini diadaptasi dari cerita lisandan mitologi lokal yang berkembang di daerah Sunda. Cerita lisan dikumpulkan melalui wawancara mendalamdengan para informan yang mewakili berbagai versi. Setidaknya terdapat enam versi tradisi lisan mengenai tokohini, yaitu versi Cikawungading, Manonjaya, Cianjur, Sukaraja, Parungponteng, dan Galunggung. Dari keenamversi tersebut terdapat variasi dan kesamaan. Naskah ini mencoba membangkitk...

  20. Akurasi Derajat Fibrosis Hati Berdasarkan King’s Score Terhadap Fibroscan Pada Penyakit Hepatitis B Kronik

    OpenAIRE

    Marpaung, Yudi Andre

    2013-01-01

    Background: A great interest has been dedicated to the development of noninvasive predictive models in recent years to substitute liver biopsy for fibrosis assessment and follow-up. Cross, et al proposed King’s Score, Age (years) x AST (IU/L) x [INR / Platelets (109 Objective: To investigate the accuracy of /L)], a simpler model consisting of routine laboratory markers for predicting liver fibrosis in patients with chronic hepatitis B in order to optimize their clinical management. King...