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Sample records for atr advanced test

  1. Atlantic Test Range (ATR)

    Data.gov (United States)

    Federal Laboratory Consortium — ATR controls fully-instrumented and integrated test ranges that provide full-service support for cradle-to-grave testing. Airspace and surface target areas are used...

  2. Advanced Test Reactor National Scientific User Facility (ATR NSUF) Monthly Report November 2014

    Energy Technology Data Exchange (ETDEWEB)

    Soelberg, Renae [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2014-11-01

    Advanced Test Reactor National Scientific User Facility (ATR NSUF) Monthly Report November 2014 Highlights Rory Kennedy and Sarah Robertson attended the American Nuclear Society Winter Meeting and Nuclear Technology Expo in Anaheim, California, Nov. 10-13. ATR NSUF exhibited at the technology expo where hundreds of meeting participants had an opportunity to learn more about ATR NSUF. Dr. Kennedy briefed the Nuclear Engineering Department Heads Organization (NEDHO) on the workings of the ATR NSUF. • Rory Kennedy, James Cole and Dan Ogden participated in a reactor instrumentation discussion with Jean-Francois Villard and Christopher Destouches of CEA and several members of the INL staff. • ATR NSUF received approval from the NE-20 office to start planning the annual Users Meeting. The meeting will be held at INL, June 22-25. • Mike Worley, director of the Office of Innovative Nuclear Research (NE-42), visited INL Nov. 4-5. Milestones Completed • Recommendations for the Summer Rapid Turnaround Experiment awards were submitted to DOE-HQ Nov. 12 (Level 2 milestone due Nov. 30). Major Accomplishments/Activities • The University of California, Santa Barbara 2 experiment was unloaded from the GE-2000 at HFEF. The experiment specimen packs will be removed and shipped to ORNL for PIE. • The Terrani experiment, one of three FY 2014 new awards, was completed utilizing the Advanced Photon Source MRCAT beamline. The experiment investigated the chemical state of Ag and Pd in SiC shell of irradiated TRISO particles via X-ray Absorption Fine Structure (XAFS) spectroscopy. Upcoming Meetings/Events • The ATR NSUF program review meeting will be held Dec. 9-10 at L’Enfant Plaza. In addition to NSUF staff and users, NE-4, NE-5 and NE-7 representatives will attend the meeting. Awarded Research Projects Boise State University Rapid Turnaround Experiments (14-485 and 14-486) Nanoindentation and TEM work on the T91, HT9, HCM12A and 9Cr ODS specimens has been completed at

  3. Cadmium Depletion Impacts on Hardening Neutron6 Spectrum for Advanced Fuel Testing in ATR

    Energy Technology Data Exchange (ETDEWEB)

    Gray S. Chang

    2011-05-01

    For transmuting long-lived isotopes contained in spent nuclear fuel into shorter-lived fission products effectively is in a fast neutron spectrum reactor. In the absence of a fast spectrum test reactor in the United States of America (USA), initial irradiation testing of candidate fuels can be performed in a thermal test reactor that has been modified to produce a test region with a hardened neutron spectrum. A test region is achieved with a Cadmium (Cd) filter which can harden the neutron spectrum to a spectrum similar (although still somewhat softer) to that of the liquid metal fast breeder reactor (LMFBR). A fuel test loop with a Cd-filter has been installed within the East Flux Trap (EFT) of the Advanced Test Reactor (ATR) at the Idaho National Laboratory (INL). A detailed comparison analyses between the cadmium (Cd) filter hardened neutron spectrum in the ATR and the LMFBR fast neutron spectrum have been performed using MCWO. MCWO is a set of scripting tools that are used to couple the Monte Carlo transport code MCNP with the isotope depletion and buildup code ORIGEN-2.2. The MCWO-calculated results indicate that the Cd-filter can effectively flatten the Rim-Effect and reduce the linear heat rate (LHGR) to meet the advanced fuel testing project requirements at the beginning of irradiation (BOI). However, the filtering characteristics of Cd as a strong absorber quickly depletes over time, and the Cd-filter must be replaced for every two typical operating cycles within the EFT of the ATR. The designed Cd-filter can effectively depress the LHGR in experimental fuels and harden the neutron spectrum enough to adequately flatten the Rim Effect in the test region.

  4. Hydraulic Shuttle Irradiation System (HSIS) Recently Installed in the Advanced Test Reactor (ATR)

    Energy Technology Data Exchange (ETDEWEB)

    A. Joseph Palmer; Gerry L. McCormick; Shannon J. Corrigan

    2010-06-01

    2010 International Congress on Advances in Nuclear Power Plants (ICAPP’10) ANS Annual Meeting Imbedded Topical San Diego, CA June 13 – 17, 2010 Hydraulic Shuttle Irradiation System (HSIS) Recently Installed in the Advanced Test Reactor (ATR) Author: A. Joseph Palmer, Mechanical Engineer, Irradiation Test Programs, 208-526-8700, Joe.Palmer@INL.gov Affiliation: Idaho National Laboratory P.O. Box 1625, MS-3840 Idaho Falls, ID 83415 INL/CON-10-17680 ABSTRACT Most test reactors are equipped with shuttle facilities (sometimes called rabbit tubes) whereby small capsules can be inserted into the reactor and retrieved during power operations. With the installation of Hydraulic Shuttle Irradiation System (HSIS) this capability has been restored to the Advanced Test Reactor (ATR) at Idaho National Laboratory (INL). The general design and operating principles of this system were patterned after the hydraulic rabbit at Oak Ridge National Laboratory’s (ORNL) High Flux Isotope Reactor (HFIR), which has operated successfully for many years. Using primary coolant as the motive medium the HSIS system is designed to simultaneously transport fourteen shuttle capsules, each 16 mm OD x 57 mm long, to and from the B-7 position of the reactor. The B-7 position is one of the higher flux positions in the reactor with typical thermal and fast (>1 Mev) fluxes of 2.8E+14 n/cm2/sec and 1.9E+14 n/cm2/sec respectively. The available space inside each shuttle is approximately 14 mm diameter x 50 mm long. The shuttle containers are made from titanium which was selected for its low neutron activation properties and durability. Shuttles can be irradiated for time periods ranging from a few minutes to several months. The Send and Receive Station (SRS) for the HSIS is located 2.5 m deep in the ATR canal which allows irradiated shuttles to be easily moved from the SRS to a wet loaded cask, or transport pig. The HSIS system first irradiated (empty) shuttles in September 2009 and has since completed

  5. Advanced Test Reactor National Scientific User Facility (ATR NSUF) Monthly Report October 2014

    Energy Technology Data Exchange (ETDEWEB)

    Ogden, Dan [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2014-10-01

    Advanced Test Reactor National Scientific User Facility (ATR NSUF) Monthly Report October 2014 Highlights • Rory Kennedy, Dan Ogden and Brenden Heidrich traveled to Germantown October 6-7, for a review of the Infrastructure Management mission with Shane Johnson, Mike Worley, Bradley Williams and Alison Hahn from NE-4 and Mary McCune from NE-3. Heidrich briefed the group on the project progress from July to October 2014 as well as the planned path forward for FY15. • Jim Cole gave two invited university seminars at Ohio State University and University of Florida, providing an overview of NSUF including available capabilities and the process for accessing facilities through the peer reviewed proposal process. • Jim Cole and Rory Kennedy co-chaired the NuMat meeting with Todd Allen. The meeting, sponsored by Elsevier publishing, was held in Clearwater, Florida, and is considered one of the premier nuclear fuels and materials conferences. Over 340 delegates attended with 160 oral and over 200 posters presented over 4 days. • Thirty-one pre-applications were submitted for NSUF access through the NE-4 Combined Innovative Nuclear Research Funding Opportunity Announcement. • Fourteen proposals were received for the NSUF Rapid Turnaround Experiment Summer 2014 call. Proposal evaluations are underway. • John Jackson and Rory Kennedy attended the Nuclear Fuels Industry Research meeting. Jackson presented an overview of ongoing NSUF industry research.

  6. LWRS ATR Irradiation Testing Readiness Status

    Energy Technology Data Exchange (ETDEWEB)

    Kristine Barrett

    2012-09-01

    The Light Water Reactor Sustainability (LWRS) Program was established by the U.S. Department of Energy Office of Nuclear Energy (DOE-NE) to develop technologies and other solutions that can improve the reliability, sustain the safety, and extend the life of the current reactors. The LWRS Program is divided into four R&D Pathways: (1) Materials Aging and Degradation; (2) Advanced Light Water Reactor Nuclear Fuels; (3) Advanced Instrumentation, Information and Control Systems; and (4) Risk-Informed Safety Margin Characterization. This report describes an irradiation testing readiness analysis in preparation of LWRS experiments for irradiation testing at the Idaho National Laboratory (INL) Advanced Test Reactor (ATR) under Pathway (2). The focus of the Advanced LWR Nuclear Fuels Pathway is to improve the scientific knowledge basis for understanding and predicting fundamental performance of advanced nuclear fuel and cladding in nuclear power plants during both nominal and off-nominal conditions. This information will be applied in the design and development of high-performance, high burn-up fuels with improved safety, cladding integrity, and improved nuclear fuel cycle economics

  7. USE OF SILICON CARBIDE MONITORS IN ATR IRRADIATION TESTING

    Energy Technology Data Exchange (ETDEWEB)

    K. L. Davis; B. Chase; T. Unruh; D. Knudson; J. L. Rempe

    2012-07-01

    In April 2007, the Department of Energy (DOE) designated the Advanced Test Reactor (ATR) a National Scientific User Facility (NSUF) to advance US leadership in nuclear science and technology. By attracting new users from universities, laboratories, and industry, the ATR will support basic and applied nuclear research and development and help address the nation's energy security needs. In support of this new program, the Idaho National Laboratory (INL) has developed in-house capabilities to fabricate, test, and qualify new and enhanced temperature sensors for irradiation testing. Although most efforts emphasize sensors capable of providing real-time data, selected tasks have been completed to enhance sensors provided in irradiation locations where instrumentation leads cannot be included, such as drop-in capsule and Hydraulic Shuttle Irradiation System (HSIS) or 'rabbit' locations. For example, silicon carbide (SiC) monitors are now available to detect peak irradiation temperatures between 200°C and 800°C. Using a resistance measurement approach, specialized equipment installed at INL's High Temperature Test Laboratory (HTTL) and specialized procedures were developed to ensure that accurate peak irradiation temperature measurements are inferred from SiC monitors irradiated at the ATR. Comparison examinations were completed by INL to demonstrate this capability, and several programs currently rely on SiC monitors for peak temperature detection. This paper discusses the use of SiC monitors at the ATR, the process used to evaluate them at the HTTL, and presents representative measurements taken using SiC monitors.

  8. Hardening neutron spectrum for advanced actinide transmutation experiments in the ATR.

    Science.gov (United States)

    Chang, G S; Ambrosek, R G

    2005-01-01

    The most effective method for transmuting long-lived isotopes contained in spent nuclear fuel into shorter-lived fission products is in a fast neutron spectrum reactor. In the absence of a fast test reactor in the United States, initial irradiation testing of candidate fuels can be performed in a thermal test reactor that has been modified to produce a test region with a hardened neutron spectrum. Such a test facility, with a spectrum similar but somewhat softer than that of the liquid-metal fast breeder reactor (LMFBR), has been constructed in the INEEL's Advanced Test Reactor (ATR). The radial fission power distribution of the actinide fuel pin, which is an important parameter in fission gas release modelling, needs to be accurately predicted and the hardened neutron spectrum in the ATR and the LMFBR fast neutron spectrum is compared. The comparison analyses in this study are performed using MCWO, a well-developed tool that couples the Monte Carlo transport code MCNP with the isotope depletion and build-up code ORIGEN-2. MCWO analysis yields time-dependent and neutron-spectrum-dependent minor actinide and Pu concentrations and detailed radial fission power profile calculations for a typical fast reactor (LMFBR) neutron spectrum and the hardened neutron spectrum test region in the ATR. The MCWO-calculated results indicate that the cadmium basket used in the advanced fuel test assembly in the ATR can effectively depress the linear heat generation rate in the experimental fuels and harden the neutron spectrum in the test region.

  9. Multiple Irradiation Capsule Experiment (MICE)-3B Irradiation Test of Space Fuel Specimens in the Advanced Test Reactor (ATR) - Close Out Documentation for Naval Reactors (NR) Information

    Energy Technology Data Exchange (ETDEWEB)

    M. Chen; CM Regan; D. Noe

    2006-01-09

    Few data exist for UO{sub 2} or UN within the notional design space for the Prometheus-1 reactor (low fission rate, high temperature, long duration). As such, basic testing is required to validate predictions (and in some cases determine) performance aspects of these fuels. Therefore, the MICE-3B test of UO{sub 2} pellets was designed to provide data on gas release, unrestrained swelling, and restrained swelling at the upper range of fission rates expected for a space reactor. These data would be compared with model predictions and used to determine adequacy of a space reactor design basis relative to fission gas release and swelling of UO{sub 2} fuel and to assess potential pellet-clad interactions. A primary goal of an irradiation test for UN fuel was to assess performance issues currently associated with this fuel type such as gas release, swelling and transient performance. Information learned from this effort may have enabled use of UN fuel for future applications.

  10. MELT WIRE SENSORS AVAILABLE TO DETERMINE PEAK TEMPERATURES IN ATR IRRADIATION TESTING

    Energy Technology Data Exchange (ETDEWEB)

    K. L. Davis; D. Knudson; J. Daw; J. Palmer; J. L. Rempe

    2012-07-01

    In April 2007, the Department of Energy (DOE) designated the Advanced Test Reactor (ATR) a National Scientific User Facility (NSUF) to advance US leadership in nuclear science and technology. By attracting new users from universities, laboratories, and industry, the ATR will support basic and applied nuclear research and development and help address the nation's energy security needs. In support of this new program, the Idaho National Laboratory (INL) has developed in-house capabilities to fabricate, test, and qualify new and enhanced temperature sensors for irradiation testing. Although most efforts emphasize sensors capable of providing real-time data, selected tasks have been completed to enhance sensors provided in irradiation locations where instrumentation leads cannot be included, such as drop-in capsule and Hydraulic Shuttle Irradiation System (HSIS) or 'rabbit' locations. To meet the need for these locations, the INL has developed melt wire temperature sensors for use in ATR irradiation testing. Differential scanning calorimetry and environmental testing of prototypical sensors was used to develop a library of 28 melt wire materials, capable of detecting peak irradiation temperatures ranging from 85 to 1500°C. This paper will discuss the development work and present test results.

  11. Independent Review of AFC 2A, 2B, and 2E ATR Irradiation Tests

    Energy Technology Data Exchange (ETDEWEB)

    M. Cappiello; R. Hobbins; K. Penny; L. Walters

    2014-01-01

    As part of the Department of Energy Advanced Fuel Cycle program, a series of fuels development irradiation tests have been performed in the Advanced Test Reactor (ATR) at the Idaho National Laboratory. These tests are providing excellent data for advanced fuels development. The program is focused on the transmutation of higher actinides which best can be accomplished in a sodium-cooled fast reactor. Because a fast test reactor is no longer available in the US, a special test vehicle is used to achieve near-prototypic fast reactor conditions (neutron spectra and temperature) for use in ATR (a water-cooled thermal reactor). As part of the testing program, there were many successful tests of advanced fuels including metals and ceramics. Recently however, there have been three experimental campaigns using metal fuels that experienced failure during irradiation. At the request of the program, an independent review committee was convened to review the post-test analyses performed by the fuels development team, to assess the conclusions of the team for the cause of the failures, to assess the adequacy and completeness of the analyses, to identify issues that were missed, and to make recommendations for improvements in the design and operation of future tests. Although there is some difference of opinion, the review committee largely agreed with the conclusions of the fuel development team regarding the cause of the failures. For the most part, the analyses that support the conclusions are sufficient.

  12. Advanced Test Reactor National Scientific User Facility

    Energy Technology Data Exchange (ETDEWEB)

    Frances M. Marshall; Jeff Benson; Mary Catherine Thelen

    2011-08-01

    The Advanced Test Reactor (ATR), at the Idaho National Laboratory (INL), is a large test reactor for providing the capability for studying the effects of intense neutron and gamma radiation on reactor materials and fuels. The ATR is a pressurized, light-water, high flux test reactor with a maximum operating power of 250 MWth. The INL also has several hot cells and other laboratories in which irradiated material can be examined to study material irradiation effects. In 2007 the US Department of Energy (DOE) designated the ATR as a National Scientific User Facility (NSUF) to facilitate greater access to the ATR and the associated INL laboratories for material testing research by a broader user community. This paper highlights the ATR NSUF research program and the associated educational initiatives.

  13. Instrumentation to Enhance Advanced Test Reactor Irradiations

    Energy Technology Data Exchange (ETDEWEB)

    J. L. Rempe; D. L. Knudson; K. G. Condie; J. E. Daw; S. C. Taylor

    2009-09-01

    The Department of Energy (DOE) designated the Advanced Test Reactor (ATR) as a National Scientific User Facility (NSUF) in April 2007 to support U.S. leadership in nuclear science and technology. By attracting new research users - universities, laboratories, and industry - the ATR will support basic and applied nuclear research and development, further advancing the nation's energy security needs. A key component of the ATR NSUF effort is to prove new in-pile instrumentation techniques that are capable of providing real-time measurements of key parameters during irradiation. To address this need, an assessment of instrumentation available and under-development at other test reactors has been completed. Based on this review, recommendations are made with respect to what instrumentation is needed at the ATR and a strategy has been developed for obtaining these sensors. Progress toward implementing this strategy is reported in this document. It is anticipated that this report will be updated on an annual basis.

  14. ATR-FTIR spectroscopic imaging: recent advances and applications to biological systems.

    Science.gov (United States)

    Kazarian, Sergei G; Chan, K L Andrew

    2013-04-07

    Attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopic imaging is a highly versatile, label free and non-destructive chemical imaging method which can be applied to study a wide range of samples and systems. This review summarises some of the recent advances and applications of this imaging method in the area of biomedical studies, including examples of section of aorta, skin tissue and live cells. Two of the major advantages of measuring in ATR mode are the opportunity to measure samples that absorb strongly in the IR spectrum, such as aqueous systems, without significant sample preparation and the ability to increase the spatial resolution of the measured image. The implications of these advantages as well as some limitations of this imaging approach are discussed and a brief outlook at some of the possible future developments in this area is provided.

  15. Irradiation Test Plan for the ATR National Scientific User Facility - University of Wisconsin Pilot Project

    Energy Technology Data Exchange (ETDEWEB)

    Heather J. MacLean; Kumar Sridharan; Timothy A. Hyde

    2008-06-01

    The performance of advanced nuclear systems critically relies on the performance of the materials used for cladding, duct, and other structural components. In many proposed advanced systems, the reactor design pushes the temperature and the total radiation dose higher than typically seen in a light water reactor. Understanding the stability of these materials under radiation is critical. There are a large number of materials or material systems that have been developed for greater high temperature or high dose performance for which little or no information on radiation response exists. The goal of this experiment is to provide initial data on the radiation response of these materials. The objective of the UW experiment is to irradiate materials of interest for advanced reactor applications at a variety of temperatures (nominally 300°C, 400°C, 500°C, and 700°C) and total dose accumulations (nominally 3 dpa and 6 dpa). Insertion of this irradiation test is proposed for September 2008 (ATR Cycle 143A).

  16. Status Report on the Fabrication of Fuel Cladding Chemical Interaction Test Articles for ATR Irradiations

    Energy Technology Data Exchange (ETDEWEB)

    Field, Kevin G. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Howard, Richard H. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2015-09-28

    FeCrAl alloys are a promising new class of alloys for light water reactor (LWR) applications due to their superior oxidation and corrosion resistance in high temperature environments. The current R&D efforts have focused on the alloy composition and processing routes to generate nuclear grade FeCrAl alloys with optimized properties for enhanced accident tolerance while maintaining properties needed for normal operation conditions. Therefore, the composition and processing routes must be optimized to maintain the high temperature steam oxidation (typically achieved by increasing the Cr and Al content) while still exhibiting properties conducive to normal operation in a LWR (such as radiation tolerance where reducing Cr content is favorable). Within this balancing act is the addition of understanding the influence on composition and processing routes on the FeCrAl alloys for fuel-cladding chemical interactions (FCCI). Currently, limited knowledge exists on FCCI for the FeCrAl-UO2 clad-fuel system. To overcome the knowledge gaps on the FCCI for the FeCrAl-UO2 clad-fuel system a series of fueled irradiation tests have been developed for irradiation in the Advanced Test Reactor (ATR) housed at the Idaho National Laboratory (INL). The first series of tests has already been reported. These tests used miniaturized 17x17 PWR fuel geometry rodlets of second-generation FeCrAl alloys fueled with industrial Westinghouse UO2 fuel. These rodlets were encapsulated within a stainless steel housing.To provide high fidelity experiments and more robust testing, a new series of rodlets have been developed deemed the Accident Tolerant Fuel Experiment #1 Oak Ridge National Laboratory FCCI test (ATF-1 ORNL FCCI). The main driving factor, which is discussed in detail, was to provide a radiation environment where prototypical fuel-clad interface temperatures are met while still maintaining constant contact between industrial fuel and the candidate cladding alloys

  17. ON-LINE MONITORING OF I&C TRANSMITTERS AND SENSORS FOR CALIBRATION VERIFICATION AND RESPONSE TIME TESTING WAS SUCCESSFULLY IMPLEMENTED AT ATR

    Energy Technology Data Exchange (ETDEWEB)

    Erickson, Phillip A.; O' Hagan, Ryan; Shumaker, Brent; Hashemian, H. M.

    2017-03-01

    The Advanced Test Reactor (ATR) has always had a comprehensive procedure to verify the performance of its critical transmitters and sensors, including RTDs, and pressure, level, and flow transmitters. These transmitters and sensors have been periodically tested for response time and calibration verification to ensure accuracy. With implementation of online monitoring techniques at ATR, the calibration verification and response time testing of these transmitters and sensors are verified remotely, automatically, hands off, include more portions of the system, and can be performed at almost any time during process operations. The work was done under a DOE funded SBIR project carried out by AMS. As a result, ATR is now able to save the manpower that has been spent over the years on manual calibration verification and response time testing of its temperature and pressure sensors and refocus those resources towards more equipment reliability needs. More importantly, implementation of OLM will help enhance the overall availability, safety, and efficiency. Together with equipment reliability programs of ATR, the integration of OLM will also help with I&C aging management goals of the Department of Energy and long-time operation of ATR.

  18. Fabrication Control Plan for ORNL RH-LOCA ATF Test Specimens to be Irradiated in the ATR

    Energy Technology Data Exchange (ETDEWEB)

    Field, Kevin G. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Howard, Richard [Idaho National Lab. (INL), Idaho Falls, ID (United States); Teague, Michael [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2014-06-01

    The purpose of this fabrication plan is (1) to summarize the design of a set of rodlets that will be fabricated and then irradiated in the Advanced Test Reactor (ATR) and (2) provide requirements for fabrication and acceptance criteria for inspections of the Light Water Reactor (LWR) – Accident Tolerant Fuels (ATF) rodlet components. The functional and operational (F&OR) requirements for the ATF program are identified in the ATF Test Plan. The scope of this document only covers fabrication and inspections of rodlet components detailed in drawings 604496 and 604497. It does not cover the assembly of these items to form a completed test irradiation assembly or the inspection of the final assembly, which will be included in a separate INL final test assembly specification/inspection document. The controls support the requirements that the test irradiations must be performed safely and that subsequent examinations must provide valid results.

  19. Combined study of biphasic and zero-order release formulations with dissolution tests and ATR-FTIR spectroscopic imaging.

    Science.gov (United States)

    Wray, Patrick; Li, Jing; Li, Ling Qiao; Kazarian, Sergei G

    2014-07-01

    In this study of multi-layer tablets, the dissolution of biphasic and zero-order release formulations has been studied primarily using attenuated total reflection-Fourier transform infrared (ATR-FTIR) spectroscopic imaging as well as UV-Vis detection of dissolved drug in the effluent stream and USP dissolution testing. Bilayer tablets, containing the excipients microcrystalline cellulose (MCC) and glucose, were used for biphasic release with nicotinamide and buflomedil as model drugs. ATR-FTIR spectroscopic imaging showed the changing component distributions during dissolution. Further experiments studied monolithic and barrier-layered tablets containing hydroxypropyl methylcellulose, MCC and buflomedil dissolving in a USP I apparatus. These data were compared with UV-Vis dissolution profiles obtained online with the ATR flow-through cell. ATR-FTIR imaging data of the biphasic formulations demonstrated that the drug release was affected by excipient ratios and effects such as interference between tablet sections. Tablets placed in the ATR-FTIR flow-through cell exhibited zero-order UV-Vis dissolution profile data at high flow rates, similar to barrier-layered formulations studied using the USP I apparatus. ATR-FTIR spectroscopic imaging provided information regarding the dissolution mechanisms in multi-layer tablets which could assist formulation development. The ability to relate data from USP dissolution tests with that from the ATR-FTIR flow-through cell could help spectroscopic imaging complement dissolution methods used in the industry.

  20. Shear Punch Testing on ATR Irradiated MA956 FeCrAl Alloy

    Energy Technology Data Exchange (ETDEWEB)

    Saleh, Tarik A. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Quintana, Matthew Estevan [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Romero, Tobias J. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2017-06-13

    The shear punch testing of irradiated and control MA956 (FeCrAl) Alloy from the NSUF-ATR-UCSB irradiation is presented. This is the first data taken on a new shear punch fixture design to test three 1.5mm punches from each 8mm x 0.5mm Disc Multipurpose Coupon (DMC). Samples were irradiated to 6.1dpa at a temperature of 315°C and 6.2 dpa at 400°C.

  1. Advanced Test Reactor National Scientific User Facility Progress

    Energy Technology Data Exchange (ETDEWEB)

    Frances M. Marshall; Todd R. Allen; James I. Cole; Jeff B. Benson; Mary Catherine Thelen

    2012-10-01

    The Advanced Test Reactor (ATR) at the Idaho National Laboratory (INL) is one of the world’s premier test reactors for studying the effects of intense neutron radiation on reactor materials and fuels. The ATR began operation in 1967, and has operated continuously since then, averaging approximately 250 operating days per year. The combination of high flux, large test volumes, and multiple experiment configuration options provide unique testing opportunities for nuclear fuels and material researchers. The ATR is a pressurized, light-water moderated and cooled, beryllium-reflected highly-enriched uranium fueled, reactor with a maximum operating power of 250 MWth. The ATR peak thermal flux can reach 1.0 x1015 n/cm2-sec, and the core configuration creates five main reactor power lobes (regions) that can be operated at different powers during the same operating cycle. In addition to these nine flux traps there are 68 irradiation positions in the reactor core reflector tank. The test positions range from 0.5” to 5.0” in diameter and are all 48” in length, the active length of the fuel. The INL also has several hot cells and other laboratories in which irradiated material can be examined to study material radiation effects. In 2007 the US Department of Energy (DOE) designated the ATR as a National Scientific User Facility (NSUF) to facilitate greater access to the ATR and the associated INL laboratories for material testing research by a broader user community. Goals of the ATR NSUF are to define the cutting edge of nuclear technology research in high temperature and radiation environments, contribute to improved industry performance of current and future light water reactors, and stimulate cooperative research between user groups conducting basic and applied research. The ATR NSUF has developed partnerships with other universities and national laboratories to enable ATR NSUF researchers to perform research at these other facilities, when the research objectives

  2. Enhanced in-pile instrumentation at the advanced test reactor

    Energy Technology Data Exchange (ETDEWEB)

    Rempe, J. L.; Knudson, D. L.; Daw, J. E.; Unruh, T.; Chase, B. M.; Palmer, J.; Condie, K. G.; Davis, K. L. [Idaho National Laboratory, MS 3840, P.O. Box 1625, Idaho Falls, ID 83415 (United States)

    2011-07-01

    Many of the sensors deployed at materials and test reactors cannot withstand the high flux/high temperature test conditions often requested by users at U.S. test reactors, such as the Advanced Test Reactor (ATR) at the Idaho National Laboratory. To address this issue, an instrumentation development effort was initiated as part of the ATR National Scientific User Facility in 2007 to support the development and deployment of enhanced in-pile sensors. This paper reports results from this effort. Specifically, this paper identifies the types of sensors currently available to support in-pile irradiations and those sensors currently available to ATR users. Accomplishments from new sensor technology deployment efforts are highlighted by describing new temperature and thermal conductivity sensors now available to ATR users. Efforts to deploy enhanced in-pile sensors for detecting elongation and realtime flux detectors are also reported, and recently-initiated research to evaluate the viability of advanced technologies to provide enhanced accuracy for measuring key parameters during irradiation testing are noted. (authors)

  3. Operational Philosophy for the Advanced Test Reactor National Scientific User Facility

    Energy Technology Data Exchange (ETDEWEB)

    J. Benson; J. Cole; J. Jackson; F. Marshall; D. Ogden; J. Rempe; M. C. Thelen

    2013-02-01

    In 2007, the Department of Energy (DOE) designated the Advanced Test Reactor (ATR) as a National Scientific User Facility (NSUF). At its core, the ATR NSUF Program combines access to a portion of the available ATR radiation capability, the associated required examination and analysis facilities at the Idaho National Laboratory (INL), and INL staff expertise with novel ideas provided by external contributors (universities, laboratories, and industry). These collaborations define the cutting edge of nuclear technology research in high-temperature and radiation environments, contribute to improved industry performance of current and future light-water reactors (LWRs), and stimulate cooperative research between user groups conducting basic and applied research. To make possible the broadest access to key national capability, the ATR NSUF formed a partnership program that also makes available access to critical facilities outside of the INL. Finally, the ATR NSUF has established a sample library that allows access to pre-irradiated samples as needed by national research teams.

  4. ATR Spent Fuel Options Study

    Energy Technology Data Exchange (ETDEWEB)

    Connolly, Michael James [Idaho National Lab. (INL), Idaho Falls, ID (United States); Bean, Thomas E. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Brower, Jeffrey O. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Luke, Dale E. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Patterson, M. W. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Robb, Alan K. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Sindelar, Robert [Idaho National Lab. (INL), Idaho Falls, ID (United States); Smith, Rebecca E. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Tonc, Vincent F. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Tripp, Julia L. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Winston, Philip L. [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2017-01-01

    The Advanced Test Reactor (ATR) is a materials and fuels test nuclear reactor that performs irradiation services for the U.S. Department of Energy (DOE) Office of Nuclear Energy (NE), Naval Reactors, the National Nuclear Security Administration (NNSA), and other research programs. ATR achieved initial criticality in 1967 and is expected to operate in support of needed missions until the year 2050 or beyond. It is anticipated that ATR will generate approximately 105 spent nuclear fuel (SNF) elements per year through the year 2050. Idaho National Laboratory (INL) currently stores 2,008 ATR SNF elements in dry storage, 976 in wet storage, and expects to have 1,000 elements in wet storage before January 2017. A capability gap exists at INL for long-term (greater than the year 2050) management, in compliance with the Idaho Settlement Agreement (ISA), of ATR SNF until a monitored retrievable geological repository is open. INL has significant wet and dry storage capabilities that are owned by the DOE Office of Environmental Management (EM) and operated and managed by Fluor Idaho, which include the Idaho Nuclear Technology and Engineering Center’s (INTEC’s) CPP-666, CPP-749, and CPP-603. In addition, INL has other capabilities owned by DOE-NE and operated and managed by Battelle Energy Alliance, LLC (BEA), which are located at the Materials and Fuel Complex (MFC). Additional storage capabilities are located on the INL Site at the Naval Reactors Facility (NRF). Current INL SNF management planning, as defined in the Fluor Idaho contract, shows INTEC dry fuel storage, which is currently used for ATR SNF, will be nearly full after transfer of an additional 1,000 ATR SNF from wet storage. DOE-NE tasked BEA with identifying and analyzing options that have the potential to fulfill this capability gap. BEA assembled a team comprised of SNF management experts from Fluor Idaho, Savannah River Site (SRS), INL/BEA, and the MITRE Corp with an objective of developing and analyzing

  5. Vanadium irradiation at ATR - neutronics aspects

    Energy Technology Data Exchange (ETDEWEB)

    Gomes, I.C.; Smith, D.L. [Argonne National Laboratory, Chicago, IL (United States)

    1995-04-01

    Calculations were performed to estimate damage and transmutation rates in vanadium irradiated in the ATR (Advanced Test Reactor) located in Idaho. The main focuses of the study are to evaluate the transmutation of vanadium to chromium and to explore ways to design the irradiation experiment to avoid excessive transmutation. It was found that the A-hole of ATR produces damage rate of {approximately} 0.2%/dpa of vanadium to chromium. A thermal neutron filter can be incorporated into the design to reduce the vanadium-to-chromium transmutation rate to low levels. A filter 1-2 mm thick of gadolinium or hafnium can be used.

  6. After Action Report: Advanced Test Reactor Complex 2015 Evaluated Drill October 6, 2015

    Energy Technology Data Exchange (ETDEWEB)

    Holmes, Forest Howard [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2015-11-01

    The Advanced Test Reactor (ATR) Complex, operated by Battelle Energy Alliance, LLC, at the Idaho National Laboratory (INL) conducted an evaluated drill on October 6, 2015, to allow the ATR Complex emergency response organization (ERO) to demonstrate the ability to respond to and mitigate an emergency by implementing the requirements of DOE O 151.1C, “Comprehensive Emergency Management System.”

  7. Status of the irradiation test vehicle for testing fusion materials in the Advanced Test Reactor

    Energy Technology Data Exchange (ETDEWEB)

    Tsai, H.; Gomes, I.C.; Smith, D.L. [Argonne National Lab., IL (United States); Palmer, A.J.; Ingram, F.W. [Lockheed Martin Idaho Technologies Co., Idaho Falls, ID (United States); Wiffen, F.W. [Dept. of Energy, Germantown, MD (United States). Office of Fusion Energy

    1998-09-01

    The design of the irradiation test vehicle (ITV) for the Advanced Test Reactor (ATR) has been completed. The main application for the ITV is irradiation testing of candidate fusion structural materials, including vanadium-base alloys, silicon carbide composites, and low-activation steels. Construction of the vehicle is underway at the Lockheed Martin Idaho Technology Company (LMITCO). Dummy test trains are being built for system checkout and fine-tuning. Reactor insertion of the ITV with the dummy test trains is scheduled for fall 1998. Barring unexpected difficulties, the ITV will be available for experiments in early 1999.

  8. Advanced turbine systems program conceptual design and product development Task 8.3 - autothermal fuel reformer (ATR). Topical report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-11-01

    Autothermal fuel reforming (ATR) consists of reacting a hydrocarbon fuel such as natural gas or diesel with steam to produce a hydrogen-rich {open_quotes}reformed{close_quotes} fuel. This work has been designed to investigate the fuel reformation and the product gas combustion under gas turbine conditions. The hydrogen-rich gas has a high flammability with a wide range of combustion stability. Being lighter and more reactive than methane, the hydrogen-rich gas mixes readily with air and can be burned at low fuel/air ratios producing inherently low emissions. The reformed fuel also has a low ignition temperature which makes low temperature catalytic combustion possible. ATR can be designed for use with a variety of alternative fuels including heavy crudes, biomass and coal-derived fuels. When the steam required for fuel reforming is raised by using energy from the gas turbine exhaust, cycle efficiency is improved because of the steam and fuel chemically recuperating. Reformation of natural gas or diesel fuels to a homogeneous hydrogen-rich fuel has been demonstrated. Performance tests on screening various reforming catalysts and operating conditions were conducted on a batch-tube reactor. Producing over 70 percent of hydrogen (on a dry basis) in the product stream was obtained using natural gas as a feedstock. Hydrogen concentration is seen to increase with temperature but less rapidly above 1300{degrees}F. The percent reforming increases as the steam to carbon ratio is increased. Two basic groups of reforming catalysts, nickel - and platinum-basis, have been tested for the reforming activity.

  9. Advanced Test Reactor National Scientific User Facility: Addressing advanced nuclear materials research

    Energy Technology Data Exchange (ETDEWEB)

    John Jackson; Todd Allen; Frances Marshall; Jim Cole

    2013-03-01

    The Advanced Test Reactor National Scientific User Facility (ATR NSUF), based at the Idaho National Laboratory in the United States, is supporting Department of Energy and industry research efforts to ensure the properties of materials in light water reactors are well understood. The ATR NSUF is providing this support through three main efforts: establishing unique infrastructure necessary to conduct research on highly radioactive materials, conducting research in conjunction with industry partners on life extension relevant topics, and providing training courses to encourage more U.S. researchers to understand and address LWR materials issues. In 2010 and 2011, several advanced instruments with capability focused on resolving nuclear material performance issues through analysis on the micro (10-6 m) to atomic (10-10 m) scales were installed primarily at the Center for Advanced Energy Studies (CAES) in Idaho Falls, Idaho. These instruments included a local electrode atom probe (LEAP), a field-emission gun scanning transmission electron microscope (FEG-STEM), a focused ion beam (FIB) system, a Raman spectrometer, and an nanoindentor/atomic force microscope. Ongoing capability enhancements intended to support industry efforts include completion of two shielded, irradiation assisted stress corrosion cracking (IASCC) test loops, the first of which will come online in early calendar year 2013, a pressurized and controlled chemistry water loop for the ATR center flux trap, and a dedicated facility intended to house post irradiation examination equipment. In addition to capability enhancements at the main site in Idaho, the ATR NSUF also welcomed two new partner facilities in 2011 and two new partner facilities in 2012; the Oak Ridge National Laboratory, High Flux Isotope Reactor (HFIR) and associated hot cells and the University California Berkeley capabilities in irradiated materials analysis were added in 2011. In 2012, Purdue University’s Interaction of Materials

  10. Criticality safety evaluation for the Advanced Test Reactor enhanced low enriched uranium fuel elements

    Energy Technology Data Exchange (ETDEWEB)

    Montierth, Leland M. [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2016-07-19

    The Global Threat Reduction Initiative (GTRI) convert program is developing a high uranium density fuel based on a low enriched uranium (LEU) uranium-molybdenum alloy. Testing of prototypic GTRI fuel elements is necessary to demonstrate integrated fuel performance behavior and scale-up of fabrication techniques. GTRI Enhanced LEU Fuel (ELF) elements based on the ATR-Standard Size elements (all plates fueled) are to be fabricated for testing in the Advanced Test Reactor (ATR). While a specific ELF element design will eventually be provided for detailed analyses and in-core testing, this criticality safety evaluation (CSE) is intended to evaluate a hypothetical ELF element design for criticality safety purposes. Existing criticality analyses have analyzed Standard (HEU) ATR elements from which controls have been derived. This CSE documents analysis that determines the reactivity of the hypothetical ELF fuel elements relative to HEU ATR elements and whether the existing HEU ATR element controls bound the ELF element. The initial calculations presented in this CSE analyzed the original ELF design, now referred to as Mod 0.1. In addition as part of a fuel meat thickness optimization effort for reactor performance other designs have been evaluated. As of early 2014 the most current conceptual designs are Mk1A and Mk1B that were previously referred to as conceptual designs Mod 0.10 and Mod 0.11, respectively. Revision 1 evaluates the reactivity of the ATR HEU Mark IV elements for a comparison with the Mark VII elements.

  11. Criticality safety evaluation for the Advanced Test Reactor enhanced low enriched uranium fuel elements

    Energy Technology Data Exchange (ETDEWEB)

    Montierth, Leland M. [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2016-07-19

    The Global Threat Reduction Initiative (GTRI) convert program is developing a high uranium density fuel based on a low enriched uranium (LEU) uranium-molybdenum alloy. Testing of prototypic GTRI fuel elements is necessary to demonstrate integrated fuel performance behavior and scale-up of fabrication techniques. GTRI Enhanced LEU Fuel (ELF) elements based on the ATR-Standard Size elements (all plates fueled) are to be fabricated for testing in the Advanced Test Reactor (ATR). While a specific ELF element design will eventually be provided for detailed analyses and in-core testing, this criticality safety evaluation (CSE) is intended to evaluate a hypothetical ELF element design for criticality safety purposes. Existing criticality analyses have analyzed Standard (HEU) ATR elements from which controls have been derived. This CSE documents analysis that determines the reactivity of the hypothetical ELF fuel elements relative to HEU ATR elements and whether the existing HEU ATR element controls bound the ELF element. The initial calculations presented in this CSE analyzed the original ELF design, now referred to as Mod 0.1. In addition, as part of a fuel meat thickness optimization effort for reactor performance, other designs have been evaluated. As of early 2014 the most current conceptual designs are Mk1A and Mk1B, that were previously referred to as conceptual designs Mod 0.10 and Mod 0.11, respectively. Revision 1 evaluates the reactivity of the ATR HEU Mark IV elements for a comparison with the Mark VII elements.

  12. Criticality Safety Evaluation for the Advanced Test Reactor U-Mo Demonstration Elements

    Energy Technology Data Exchange (ETDEWEB)

    Leland M. Montierth

    2010-12-01

    The Reduced Enrichment Research Test Reactors (RERTR) fuel development program is developing a high uranium density fuel based on a (LEU) uranium-molybdenum alloy. Testing of prototypic RERTR fuel elements is necessary to demonstrate integrated fuel performance behavior and scale-up of fabrication techniques. Two RERTR-Full Size Demonstration fuel elements based on the ATR-Reduced YA elements (all but one plate fueled) are to be fabricated for testing in the Advanced Test Reactor (ATR). The two fuel elements will be irradiated in alternating cycles such that only one element is loaded in the reactor at a time. Existing criticality analyses have analyzed Standard (HEU) ATR elements (all plates fueled) from which controls have been derived. This criticality safety evaluation (CSE) documents analysis that determines the reactivity of the Demonstration fuel elements relative to HEU ATR elements and shows that the Demonstration elements are bound by the Standard HEU ATR elements and existing HEU ATR element controls are applicable to the Demonstration elements.

  13. IRRADIATION TESTING OF THE RERTR FUEL MINIPLATES WITH BURNABLE ABSORBERS IN THE ADVANCED TEST REACTOR

    Energy Technology Data Exchange (ETDEWEB)

    I. Glagolenko; D. Wachs; N. Woolstenhulme; G. Chang; B. Rabin; C. Clark; T. Wiencek

    2010-10-01

    Based on the results of the reactor physics assessment, conversion of the Advanced Test Reactor (ATR) at the Idaho National Laboratory (INL) can be potentially accomplished in two ways, by either using U-10Mo monolithic or U-7Mo dispersion type plates in the ATR fuel element. Both designs, however, would require incorporation of the burnable absorber in several plates of the fuel element to compensate for the excess reactivity and to flatten the radial power profile. Several different types of burnable absorbers were considered initially, but only borated compounds, such as B4C, ZrB2 and Al-B alloys, were selected for testing primarily due to the length of the ATR fuel cycle and fuel manufacturing constraints. To assess and compare irradiation performance of the U-Mo fuels with different burnable absorbers we have designed and manufactured 28 RERTR miniplates (20 fueled and 8 non-fueled) containing fore-mentioned borated compounds. These miniplates will be tested in the ATR as part of the RERTR-13 experiment, which is described in this paper. Detailed plate design, compositions and irradiations conditions are discussed.

  14. Advanced tokamak reactors based on the spherical torus (ATR/ST). Preliminary design considerations

    Energy Technology Data Exchange (ETDEWEB)

    Miller, R.L.; Krakowski, R.A.; Bathke, C.G.; Copenhaver, C.; Schnurr, N.M.; Engelhardt, A.G.; Seed, T.J.; Zubrin, R.M.

    1986-06-01

    Preliminary design results relating to an advanced magnetic fusion reactor concept based on the high-beta, low-aspect-ratio, spherical-torus tokamak are summarized. The concept includes resistive (demountable) toroidal-field coils, magnetic-divertor impurity control, oscillating-field current drive, and a flowing liquid-metal breeding blanket. Results of parametric tradeoff studies, plasma engineering modeling, fusion-power-core mechanical design, neutronics analyses, and blanket thermalhydraulics studies are described. The approach, models, and interim results described here provide a basis for a more detailed design. Key issues quantified for the spherical-torus reactor center on the need for an efficient drive for this high-current (approx.40 MA) device as well as the economic desirability to increase the net electrical power from the nominal 500-MWe(net) value adopted for the baseline system. Although a direct extension of present tokamak scaling, the stablity and transport of this high-beta (approx.0.3) plasma is a key unknown that is resoluble only by experiment. The spherical torus generally provides a route to improved tokamak reactors as measured by considerably simplified coil technology in a configuration that allows a realistic magnetic divertor design, both leading to increased mass power density and reduced cost.

  15. ATR Power Supplies

    Energy Technology Data Exchange (ETDEWEB)

    Bruno, Don [Brookhaven National Lab. (BNL), Upton, NY (United States)

    1996-09-10

    The ATR (AGS to RHIC Transfer Line) is fed beam from two synchrotron rings. The first synchrotron ring is the Booster which receives protons from a 200MeV Linac and can achieve a proton energy of 1.5GeV. The Booster can also receive heavy ions from a 15.5MV Tandem Van de Graaff. The Booster is about 1/8 of a mile in circumference. The Booser then Feeds the AGS (Alternating Gradient Synchrotron) wich can achieve a proton energy of 29.5 Gev. The AGS is about 1/2 of a mile in circumference. The AGS then kicks the beam out to the ATR line which will eventually feed RHIC (Relativistic Heavy Ion Collider) beam starting with the sextant test in December of 1996. The ATR line is about 1/2 mile long. The ATR line is made up of the upgraded U-line, new W, X and Y lines (see Figure 1). The test in November and December of 1995 transported beam from the AGS to the end of the W-line into a beam stop. During the normal operation of RHIC there will be a switching magnet at the end of the W-line which will bend beam into the X-Line and then into the Y-line so that the two beams in RHIC will be rotating in opposite directions.

  16. PUREX new substation ATR

    Energy Technology Data Exchange (ETDEWEB)

    Nelson, D.E.

    1997-05-12

    This document is the acceptance test report (ATR) for the New PUREX Main and Minisubstations. It covers the factory and vendor acceptance and commissioning test reports. Reports are presented for the Main 5 kV substation building, the building fire system, switchgear, and vacuum breaker; the minisubstation control building and switch gear; commissioning test; electrical system and loads inspection; electrical utilities transformer and cable; and relay setting changes based on operational experience.

  17. 10 CFR 830 Major Modification Determination for the Advanced Test Reactor Remote Monitoring and Management Capability

    Energy Technology Data Exchange (ETDEWEB)

    Bohachek, Randolph Charles [Idaho National Laboratory (INL), Idaho Falls, ID (United States)

    2015-09-01

    The Advanced Test Reactor (ATR; TRA-670), which is located in the ATR Complex at Idaho National Laboratory, was constructed in the 1960s for the purpose of irradiating reactor fuels and materials. Other irradiation services, such as radioisotope production, are also performed at ATR. While ATR is safely fulfilling current mission requirements, assessments are continuing. These assessments intend to identify areas to provide defense–in-depth and improve safety for ATR. One of the assessments performed by an independent group of nuclear industry experts recommended that a remote accident management capability be provided. The report stated that: “contemporary practice in commercial power reactors is to provide a remote shutdown station or stations to allow shutdown of the reactor and management of long-term cooling of the reactor (i.e., management of reactivity, inventory, and cooling) should the main control room be disabled (e.g., due to a fire in the control room or affecting the control room).” This project will install remote reactor monitoring and management capabilities for ATR. Remote capabilities will allow for post scram reactor management and monitoring in the event the main Reactor Control Room (RCR) must be evacuated.

  18. IMPROVED COMPUTATIONAL NEUTRONICS METHODS AND VALIDATION PROTOCOLS FOR THE ADVANCED TEST REACTOR

    Energy Technology Data Exchange (ETDEWEB)

    David W. Nigg; Joseph W. Nielsen; Benjamin M. Chase; Ronnie K. Murray; Kevin A. Steuhm

    2012-04-01

    The Idaho National Laboratory (INL) is in the process of modernizing the various reactor physics modeling and simulation tools used to support operation and safety assurance of the Advanced Test Reactor (ATR). Key accomplishments so far have encompassed both computational as well as experimental work. A new suite of stochastic and deterministic transport theory based reactor physics codes and their supporting nuclear data libraries (HELIOS, KENO6/SCALE, NEWT/SCALE, ATTILA, and an extended implementation of MCNP5) has been installed at the INL. Corresponding models of the ATR and ATRC are now operational with all five codes, demonstrating the basic feasibility of the new code packages for their intended purpose. Of particular importance, a set of as-run core depletion HELIOS calculations for all ATR cycles since August 2009 was successfully completed during 2011. This demonstration supported a decision late in the year to proceed with the phased incorporation of the HELIOS methodology into the ATR fuel cycle management process beginning in 2012. On the experimental side of the project, new hardware was fabricated, measurement protocols were finalized, and the first four of six planned physics code validation experiments based on neutron activation spectrometry were conducted at the ATRC facility. Data analysis for the first three experiments, focused on characterization of the neutron spectrum in one of the ATR flux traps, has been completed. The six experiments will ultimately form the basis for a flexible, easily-repeatable ATR physics code validation protocol that is consistent with applicable ASTM standards.

  19. Validation of High-Fidelity Reactor Physics Models for Support of the KJRR Experimental Campaign in the Advanced Test Reactor

    Energy Technology Data Exchange (ETDEWEB)

    Nigg, David W.; Nielsen, Joseph W.; Norman, Daren R.

    2017-07-01

    The Korea Atomic Energy Research Institute is currently in the process of qualifying a Low-Enriched Uranium fuel element design for the new Ki-Jang Research Reactor (KJRR). As part of this effort, a prototype KJRR fuel element was irradiated for several operating cycles in the Northeast Flux Trap of the Advanced Test Reactor (ATR) at the Idaho National Laboratory. The KJRR fuel element contained a very large quantity of fissile material (618g 235U) in comparison with historical ATR experiment standards (<1g 235U), and its presence in the ATR flux trap was expected to create a neutronic configuration that would be well outside of the approved validation envelope for the reactor physics analysis methods used to support ATR operations. Accordingly it was necessary, prior to high-power irradiation of the KJRR fuel element in the ATR, to conduct an extensive set of new low-power physics measurements with the KJRR fuel element installed in the ATR Critical Facility (ATRC), a companion facility to the ATR that is located in an immediately adjacent building, sharing the same fuel handling and storage canal. The new measurements had the objective of expanding the validation envelope for the computational reactor physics tools used to support ATR operations and safety analysis to include the planned KJRR irradiation in the ATR and similar experiments that are anticipated in the future. The computational and experimental results demonstrated that the neutronic behavior of the KJRR fuel element in the ATRC is well-understood, both in terms of its general effects on core excess reactivity and fission power distributions, its effects on the calibration of the core lobe power measurement system, as well as in terms of its own internal fission rate distribution and total fission power per unit ATRC core power. Taken as a whole, these results have significantly extended the ATR physics validation envelope, thereby enabling an entire new class of irradiation experiments.

  20. Status of ATR-A1 irradiation experiment on vanadium alloys and low-activation steels

    Energy Technology Data Exchange (ETDEWEB)

    Tsai, H.; Strain, R.V.; Gomes, I.; Chung, H.; Smith, D.L. [Argonne National Lab., IL (United States)] [and others

    1997-04-01

    The ATR-A1 irradiation experiment in the Advanced Test Reactor (ATR) was a collaborative U.S./Japan effort to study at low temperatures the effects of neutron damage on vanadium alloys. The experiment also contained a limited quantity of low-activation ferritic steel specimens from Japan as part of the collaboration agreement. The irradiation was completed on May 5, 1996, as planned, after achieving an estimated neutron damage of 4.7 dpa in vanadium. The capsule has since been kept in the ATR water canal for the required radioactivity cool-down. Planning is underway for disassembly of the capsule and test specimen retrieval.

  1. Design considerations of the irradiation test vehicle for the advanced test reactor

    Energy Technology Data Exchange (ETDEWEB)

    Tsai, H.; Gomes, I.C.; Smith, D.L. [Argonne National Lab., IL (United States)] [and others

    1997-08-01

    An irradiation test vehicle (ITV) for the Advanced Test Reactor (ATR) is being jointly developed by the Lockheed Martin Idaho Technologies Company (LMIT) and the U.S. Fusion Program. The vehicle is intended for neutron irradiation testing of candidate structural materials, including vanadium-based alloys, silicon carbide composites, and low activation steels. It could possibly be used for U.S./Japanese collaboration in the Jupiter Program. The first test train is scheduled to be completed by September 1998. In this report, we present the functional requirements for the vehicle and a preliminary design that satisfies these requirements.

  2. New Sensors for the Advanced Test Reactor National Scientific User Facility

    Energy Technology Data Exchange (ETDEWEB)

    Joy L. Rempe; Darrell L. Knudson; Keith G. Condie; Joshua E. Daw; Heng Ban; Brandon Fox; Gordon Kohse

    2009-06-01

    A key component of the ATR NSUF effort is to develop and evaluate new in-pile instrumentation techniques that are capable of providing real-time measurements of key parameters during irradiation. This paper describes the selection strategy of what instrumentation is needed, and the program generated for developing new or enhanced sensors that can address these needs. Accomplishments from this program are illustrated by describing new sensors now available to users of the ATR NSUF with data from irradiation tests using these sensors. In addition, progress is reported on current research efforts to provide users advanced methods for detecting temperature, fuel thermal conductivity, and changes in sample geometry.

  3. Opportunities for mixed oxide fuel testing in the advanced test reactor to support plutonium disposition

    Energy Technology Data Exchange (ETDEWEB)

    Terry, W.K.; Ryskamp, J.M.; Sterbentz, J.W. [and others

    1995-08-01

    Numerous technical issues must be resolved before LWR operating licenses can be amended to allow the use of MOX fuel. These issues include the following: (1) MOX fuel fabrication process verification; (2) Whether and how to use burnable poisons to depress MOX fuel initial reactivity, which is higher than that of urania; (3) The effects of WGPu isotopic composition; (4) The feasibility of loading MOX fuel with plutonia content up to 7% by weight; (5) The effects of americium and gallium in WGPu; (6) Fission gas release from MOX fuel pellets made from WGPu; (7) Fuel/cladding gap closure; (8) The effects of power cycling and off-normal events on fuel integrity; (9) Development of radial distributions of burnup and fission products; (10) Power spiking near the interfaces of MOX and urania fuel assemblies; and (11) Fuel performance code validation. The Advanced Test Reactor (ATR) at the Idaho National Engineering Laboratory possesses many advantages for performing tests to resolve most of the issues identified above. We have performed calculations to show that the use of hafnium shrouds can produce spectrum adjustments that will bring the flux spectrum in ATR test loops into a good approximation to the spectrum anticipated in a commercial LWR containing MOX fuel while allowing operation of the test fuel assemblies near their optimum values of linear heat generation rate. The ATR would be a nearly ideal test bed for developing data needed to support applications to license LWRs for operation with MOX fuel made from weapons-grade plutonium. The requirements for planning and implementing a test program in the ATR have been identified. The facilities at Argonne National Laboratory-West can meet all potential needs for pre- and post-irradiation examination that might arise in a MOX fuel qualification program.

  4. Neutron dosimetry and damage calculations for the ATR-A1 irradiation

    Energy Technology Data Exchange (ETDEWEB)

    Greenwood, L.R.; Ratner, R.T. [Pacific Northwest National Lab., Richland, WA (United States)

    1998-09-01

    Neutron fluence measurements and radiation damage calculations are reported for the collaborative US/Japan ATR-A1 irradiation in the Advanced Test Reactor (ATR) at Idaho National Engineering Laboratory (INEL). The maximum total neutron fluence at midplane was 9.4 {times} 10{sup 21} n/cm{sup 2} (5.5 {times} 10{sup 21} n/cm{sup 2} above 0.1 MeV), resulting in about 4.6 dpa in vanadium.

  5. ATR PDQ and MCWO Fuel Burnup Analysis Codes Evaluation

    Energy Technology Data Exchange (ETDEWEB)

    G.S. Chang; P. A. Roth; M. A. Lillo

    2009-11-01

    The Advanced Test Reactor (ATR) at the Idaho National Laboratory (INL) is being studied to determine the feasibility of converting it from the highly enriched Uranium (HEU) fuel that is currently uses to low enriched Uranium (LEU) fuel. In order to achieve this goal, it would be best to qualify some different computational methods than those that have been used at ATR for the past 40 years. This paper discusses two methods of calculating the burnup of ATR fuel elements. The existing method, that uses the PDQ code, is compared to a modern method that uses A General Monte Carlo N-Particle Transport Code (MCNP) combined with the Origen2.2 code. This modern method, MCNP with ORIGEN2.2 (MCWO), is found to give excellent agreement with the existing method (PDQ). Both of MCWO and PDQ are also in a very good agreement to the 235U burnup data generated by an analytical method.

  6. Status Report on Efforts to Enhance Instrumentation to Support Advanced Test Reactor Irradiations

    Energy Technology Data Exchange (ETDEWEB)

    J. Rempe; D. Knudson; J. Daw; T. Unruh; B. Chase; R. Schley; J. Palmer; K. Condie

    2014-01-01

    The Department of Energy (DOE) designated the Advanced Test Reactor (ATR) as a National Scientific User Facility (NSUF) in April 2007 to support the growth of nuclear science and technology in the United States (US). By attracting new research users - universities, laboratories, and industry - the ATR NSUF facilitates basic and applied nuclear research and development, further advancing the nation's energy security needs. A key component of the ATR NSUF effort at the Idaho National Laboratory (INL) is to design, develop, and deploy new in-pile instrumentation techniques that are capable of providing real-time measurements of key parameters during irradiation. To address this need, an assessment of instrumentation available and under-development at other test reactors was completed. Based on this initial review, recommendations were made with respect to what instrumentation is needed at the ATR, and a strategy was developed for obtaining these sensors. In 2009, a report was issued documenting this program’s strategy and initial progress toward accomplishing program objectives. Since 2009, annual reports have been issued to provide updates on the program strategy and the progress made on implementing the strategy. This report provides an update reflecting progress as of January 2014.

  7. Status Report on Efforts to Enhance Instrumentation to Support Advanced Test Reactor Irradiations

    Energy Technology Data Exchange (ETDEWEB)

    J. L. Rempe; D. L. Knudson; J. E. Daw

    2011-03-01

    The Department of Energy (DOE) designated the Advanced Test Reactor (ATR) as a National Scientific User Facility (NSUF) in April 2007 to support U.S. leadership in nuclear science and technology. By attracting new research users - universities, laboratories, and industry - the ATR NSUF facilitates basic and applied nuclear research and development, further advancing the nation's energy security needs. A key component of the ATR NSUF effort is to prove new in-pile instrumentation techniques that are capable of providing real-time measurements of key parameters during irradiation. To address this need, an assessment of instrumentation available and under-development at other test reactors was completed. Based on this review, recommendations were made with respect to what instrumentation is needed at the ATR; and a strategy was developed for obtaining these sensors. In 2009, a report was issued documenting this program’s strategy and initial progress toward accomplishing program objectives. In 2009, a report was issued documenting this instrumentation development strategy and initial progress toward accomplishing instrumentation development program objectives. This document reports progress toward implementing this strategy in 2010.

  8. Advanced Superconducting Test Accelerator (ASTA)

    Data.gov (United States)

    Federal Laboratory Consortium — The Advanced Superconducting Test Accelerator (ASTA) facility will be based on upgrades to the existing NML pulsed SRF facility. ASTA is envisioned to contain 3 to 6...

  9. Advanced Superconducting Test Accelerator (ASTA)

    Data.gov (United States)

    Federal Laboratory Consortium — The Advanced Superconducting Test Accelerator (ASTA) facility will be based on upgrades to the existing NML pulsed SRF facility. ASTA is envisioned to contain 3 to...

  10. Preliminary Feasibility, Design, and Hazard Analysis of a Boiling Water Test Loop Within the Idaho National Laboratory Advanced Test Reactor National Scientific User Facility

    Energy Technology Data Exchange (ETDEWEB)

    Douglas M. Gerstner

    2009-05-01

    The Advanced Test Reactor (ATR) is a pressurized light-water reactor with a design thermal power of 250 MW. The principal function of the ATR is to provide a high neutron flux for testing reactor fuels and other materials. The ATR and its support facilities are located at the Idaho National Laboratory (INL). A Boiling Water Test Loop (BWTL) is being designed for one of the irradiation test positions within the. The objective of the new loop will be to simulate boiling water reactor (BWR) conditions to support clad corrosion and related reactor material testing. Further it will accommodate power ramping tests of candidate high burn-up fuels and fuel pins/rods for the commercial BWR utilities. The BWTL will be much like the pressurized water loops already in service in 5 of the 9 “flux traps” (region of enhanced neutron flux) in the ATR. The loop coolant will be isolated from the primary coolant system so that the loop’s temperature, pressure, flow rate, and water chemistry can be independently controlled. This paper presents the proposed general design of the in-core and auxiliary BWTL systems; the preliminary results of the neutronics and thermal hydraulics analyses; and the preliminary hazard analysis for safe normal and transient BWTL and ATR operation.

  11. Advanced Vehicle Testing and Evaluation

    Energy Technology Data Exchange (ETDEWEB)

    Garetson, Thomas [The Clarity Group, Incorporated, Chicago, IL (United States)

    2013-03-31

    The objective of the United States (U.S.) Department of Energy's (DOEs) Advanced Vehicle Testing and Evaluation (AVTE) project was to provide test and evaluation services for advanced technology vehicles, to establish a performance baseline, to determine vehicle reliability, and to evaluate vehicle operating costs in fleet operations.Vehicles tested include light and medium-duty vehicles in conventional, hybrid, and all-electric configurations using conventional and alternative fuels, including hydrogen in internal combustion engines. Vehicles were tested on closed tracks and chassis dynamometers, as well as operated on public roads, in fleet operations, and over prescribed routes. All testing was controlled by procedures developed specifically to support such testing.

  12. Advanced Vehicle Testing and Evaluation

    Energy Technology Data Exchange (ETDEWEB)

    Garetson, Thomas [The Clarity Group, Incorporated, Chicago, IL (United States)

    2013-03-31

    The objective of the United States (U.S.) Department of Energy's (DOEs) Advanced Vehicle Testing and Evaluation (AVTE) project was to provide test and evaluation services for advanced technology vehicles, to establish a performance baseline, to determine vehicle reliability, and to evaluate vehicle operating costs in fleet operations.Vehicles tested include light and medium-duty vehicles in conventional, hybrid, and all-electric configurations using conventional and alternative fuels, including hydrogen in internal combustion engines. Vehicles were tested on closed tracks and chassis dynamometers, as well as operated on public roads, in fleet operations, and over prescribed routes. All testing was controlled by procedures developed specifically to support such testing.

  13. A Simplified Shuttle Irradiation Facility for ATR

    Energy Technology Data Exchange (ETDEWEB)

    Palmer, Alma Joseph; Laflin, S. T.

    1999-09-01

    During the past fifteen years there has been a steady increase in the demand for radioisotopes in nuclear medicine and a corresponding decline in the number of reactors within the U.S. capable of producing them. The Advanced Test Reactor (ATR) is the largest operating test reactor in the U.S., but its isotope production capabilities have been limited by the lack of an installed isotope shuttle irradiation system. A concept for a simple “low cost” shuttle irradiation facility for ATR has been developed. Costs were reduced (in comparison to previous ATR designs) by using a shielded trough of water installed in an occupiable cubicle as a shielding and contamination control barrier for the send and receive station. This shielding concept also allows all control valves to be operated by hand and thus the need for an automatic control system was eliminated. It was determined that 4 – 5 ft of water would be adequate to shield the isotopes of interest while shuttles are transferred to a small carrier. An additional feature of the current design is a non-isolatable by-pass line, which provides a minimum coolant flow to the test region regardless of which control valves are opened or closed. This by-pass line allows the shuttle facility to be operated without bringing reactor coolant water into the cubicle except for send and receive operations. The irradiation position selected for this concept is a 1.5 inch “B” hole (B-11). This position provides neutron fluxes of approximately: 1.6 x 1014 (<0.5 eV) and 4.0 x 1013 (>0.8 MeV) n/cm2*sec.

  14. Advanced Test Reactor Core Modeling Update Project Annual Report for Fiscal Year 2010

    Energy Technology Data Exchange (ETDEWEB)

    Rahmat Aryaeinejad; Douglas S. Crawford; Mark D. DeHart; George W. Griffith; D. Scott Lucas; Joseph W. Nielsen; David W. Nigg; James R. Parry; Jorge Navarro

    2010-09-01

    Legacy computational reactor physics software tools and protocols currently used for support of Advanced Test Reactor (ATR) core fuel management and safety assurance and, to some extent, experiment management are obsolete, inconsistent with the state of modern nuclear engineering practice, and are becoming increasingly difficult to properly verify and validate (V&V). Furthermore, the legacy staff knowledge required for application of these tools and protocols from the 1960s and 1970s is rapidly being lost due to staff turnover and retirements. In 2009 the Idaho National Laboratory (INL) initiated a focused effort to address this situation through the introduction of modern high-fidelity computational software and protocols, with appropriate V&V, within the next 3-4 years via the ATR Core Modeling and Simulation and V&V Update (or “Core Modeling Update”) Project. This aggressive computational and experimental campaign will have a broad strategic impact on the operation of the ATR, both in terms of improved computational efficiency and accuracy for support of ongoing DOE programs as well as in terms of national and international recognition of the ATR National Scientific User Facility (NSUF).

  15. Advanced Test Reactor Core Modeling Update Project Annual Report for Fiscal Year 2013

    Energy Technology Data Exchange (ETDEWEB)

    David W. Nigg

    2013-09-01

    Legacy computational reactor physics software tools and protocols currently used for support of Advanced Test Reactor (ATR) core fuel management and safety assurance, and to some extent, experiment management, are inconsistent with the state of modern nuclear engineering practice, and are difficult, if not impossible, to verify and validate (V&V) according to modern standards. Furthermore, the legacy staff knowledge required for effective application of these tools and protocols from the 1960s and 1970s is rapidly being lost due to staff turnover and retirements. In late 2009, the Idaho National Laboratory (INL) initiated a focused effort, the ATR Core Modeling Update Project, to address this situation through the introduction of modern high-fidelity computational software and protocols. This aggressive computational and experimental campaign will have a broad strategic impact on the operation of the ATR, both in terms of improved computational efficiency and accuracy for support of ongoing DOE programs as well as in terms of national and international recognition of the ATR National Scientific User Facility (NSUF).

  16. Feasibility of conducting a dynamic helium charging experiment for vanadium alloys in the advanced test reactor

    Energy Technology Data Exchange (ETDEWEB)

    Tsai, H.; Gomes, I.; Strain, R.V.; Smith, D.L. [Argonne National Lab., IL (United States); Matsui, H. [Tohoku Univ. (Japan)

    1996-10-01

    The feasibility of conducting a dynamic helium charging experiment (DHCE) for vanadium alloys in the water-cooled Advanced Test Reactor (ATR) is being investigated as part of the U.S./Monbusho collaboration. Preliminary findings suggest that such an experiment is feasible, with certain constraints. Creating a suitable irradiation position in the ATR, designing an effective thermal neutron filter, incorporating thermocouples for limited specimen temperature monitoring, and handling of tritium during various phases of the assembly and reactor operation all appear to be feasible. An issue that would require special attention, however, is tritium permeation loss through the capsule wall at the higher design temperatures (>{approx}600{degrees}C). If permeation is excessive, the reduced amount of tritium entering the test specimens would limit the helium generation rates in them. At the lower design temperatures (<{approx}425{degrees}C), sodium, instead of lithium, may have to be used as the bond material to overcome the tritium solubility limitation.

  17. AGR-2 Data Qualification Report for ATR Cycle 154B

    Energy Technology Data Exchange (ETDEWEB)

    Binh Pham; Jeff Einerson

    2014-01-01

    This report provides the data qualification status of Advanced Gas Reactor-2 (AGR-2) fuel irradiation experimental data from Advanced Test Reactor (ATR) Cycle 154B as recorded in the Nuclear Data Management and Analysis System (NDMAS). This is the last cycle of AGR-2 irradiation, as the test train was pulled from the ATR core during the outage portion of ATR Cycle 155A. The AGR-2 data streams addressed in this report include thermocouple (TC) temperatures, sweep gas data (flow rates including new Fission Product Monitoring (FPM) downstream flows from Fission Product Monitoring System (FPMS) detectors, pressure, and moisture content), and FPMS data (release rates and release-to-birth rate ratios [R/Bs]) for each of the six capsules in the AGR-2 experiment. The final data qualification status for these data streams is determined by a Data Review Committee (DRC) comprised of AGR technical leads, Sitewide Quality Assurance (QA), and NDMAS analysts. The Data Review Committee reviewed the data acquisition process, considered whether the data met the requirements for data collection as specified in QA-approved Very High Temperature Reactor (VHTR) data collection plans, examined the results of NDMAS data testing and statistical analyses, and confirmed the qualification status of the data as given in this report.

  18. Advanced Test Reactor National Scientific User Facility (ATR NSUF) Monthly Report December 2014

    Energy Technology Data Exchange (ETDEWEB)

    Renae Soelberg

    2014-12-01

    • PNNL has completed sectioning of the U.C. Berkeley hydride fuel rodlet 1 (highest burn-up) and is currently polishing samples in preparation for optical metallography. • A disk was successfully sectioned from rodlet 1 at the location of the internal thermocouple tip as desired. The transition from annular pellet to solid pellet is verified by the eutectic-filled inner cavity located on the back face of this disk (top left) and the solid front face (bottom left). Preliminary low-resolution images indicate interesting sample characteristics in the eutectic surrounding the rodlet at the location of the outer thermocouple tip (right). This sample has been potted and is currently being polished for high-resolution optical microscopy and subsequent SEM analysis. (See images.)

  19. Assessment of Feasibility of the Beneficial Use of Waste Heat from the Advanced Test Reactor

    Energy Technology Data Exchange (ETDEWEB)

    Donna P. Guillen

    2012-07-01

    This report investigates the feasibility of using waste heat from the Advanced Test Reactor (ATR). A proposed glycol waste heat recovery system was assessed for technical and economic feasibility. The system under consideration would use waste heat from the ATR secondary coolant system to preheat air for space heating of TRA-670. A tertiary coolant stream would be extracted from the secondary coolant system loop and pumped to a new plate and frame heat exchanger, where heat would be transferred to a glycol loop for preheating outdoor air in the heating and ventilation system. Historical data from Advanced Test Reactor operations over the past 10 years indicates that heat from the reactor coolant was available (when needed for heating) for 43.5% of the year on average. Potential energy cost savings by using the waste heat to preheat intake air is $242K/yr. Technical, safety, and logistics considerations of the glycol waste heat recovery system are outlined. Other opportunities for using waste heat and reducing water usage at ATR are considered.

  20. ATR performance modeling concepts

    Science.gov (United States)

    Ross, Timothy D.; Baker, Hyatt B.; Nolan, Adam R.; McGinnis, Ryan E.; Paulson, Christopher R.

    2016-05-01

    Performance models are needed for automatic target recognition (ATR) development and use. ATRs consume sensor data and produce decisions about the scene observed. ATR performance models (APMs) on the other hand consume operating conditions (OCs) and produce probabilities about what the ATR will produce. APMs are needed for many modeling roles of many kinds of ATRs (each with different sensing modality and exploitation functionality combinations); moreover, there are different approaches to constructing the APMs. Therefore, although many APMs have been developed, there is rarely one that fits a particular need. Clarified APM concepts may allow us to recognize new uses of existing APMs and identify new APM technologies and components that better support coverage of the needed APMs. The concepts begin with thinking of ATRs as mapping OCs of the real scene (including the sensor data) to reports. An APM is then a mapping from explicit quantized OCs (represented with less resolution than the real OCs) and latent OC distributions to report distributions. The roles of APMs can be distinguished by the explicit OCs they consume. APMs used in simulations consume the true state that the ATR is attempting to report. APMs used online with the exploitation consume the sensor signal and derivatives, such as match scores. APMs used in sensor management consume neither of those, but estimate performance from other OCs. This paper will summarize the major building blocks for APMs, including knowledge sources, OC models, look-up tables, analytical and learned mappings, and tools for signal synthesis and exploitation.

  1. Fabrication Report for the AFC-2A and AFC-2B Capsule Irradiations in the ATR

    Energy Technology Data Exchange (ETDEWEB)

    Timothy A. Hyde

    2007-10-01

    This document provides a general narrative description of the AFC-2A and 2B fuel fabrication processes for the AFC 2A and AFC 2B fuel irradiation experiments fabricated at the Idaho National Laboratory’s Materials and Fuels Complex (MFC) for irradiation in the Advanced Test Reactor (ATR).

  2. Advanced Test Reactor Core Modeling Update Project Annual Report for Fiscal Year 2012

    Energy Technology Data Exchange (ETDEWEB)

    David W. Nigg, Principal Investigator; Kevin A. Steuhm, Project Manager

    2012-09-01

    Legacy computational reactor physics software tools and protocols currently used for support of Advanced Test Reactor (ATR) core fuel management and safety assurance, and to some extent, experiment management, are inconsistent with the state of modern nuclear engineering practice, and are difficult, if not impossible, to properly verify and validate (V&V) according to modern standards. Furthermore, the legacy staff knowledge required for application of these tools and protocols from the 1960s and 1970s is rapidly being lost due to staff turnover and retirements. In late 2009, the Idaho National Laboratory (INL) initiated a focused effort, the ATR Core Modeling Update Project, to address this situation through the introduction of modern high-fidelity computational software and protocols. This aggressive computational and experimental campaign will have a broad strategic impact on the operation of the ATR, both in terms of improved computational efficiency and accuracy for support of ongoing DOE programs as well as in terms of national and international recognition of the ATR National Scientific User Facility (NSUF). The ATR Core Modeling Update Project, targeted for full implementation in phase with the next anticipated ATR Core Internals Changeout (CIC) in the 2014-2015 time frame, began during the last quarter of Fiscal Year 2009, and has just completed its third full year. Key accomplishments so far have encompassed both computational as well as experimental work. A new suite of stochastic and deterministic transport theory based reactor physics codes and their supporting nuclear data libraries (HELIOS, KENO6/SCALE, NEWT/SCALE, ATTILA, and an extended implementation of MCNP5) has been installed at the INL under various licensing arrangements. Corresponding models of the ATR and ATRC are now operational with all five codes, demonstrating the basic feasibility of the new code packages for their intended purpose. Of particular importance, a set of as-run core

  3. Validation of HELIOS for ATR Core Follow Analyses

    Energy Technology Data Exchange (ETDEWEB)

    Bays, Samuel E. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Swain, Emily T. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Crawford, Douglas S. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Nigg, David W. [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2015-03-01

    This work summarizes the validation analyses for the HELIOS code to support core design and safety assurance calculations of the Advanced Test Reactor (ATR). Past and current core safety assurance is performed by the PDQ-7 diffusion code; a state of the art reactor physics simulation tool from the nuclear industry’s earlier days. Over the past twenty years, improvements in computational speed have enabled the use of modern neutron transport methodologies to replace the role of diffusion theory for simulation of complex systems, such as the ATR. More exact methodologies have enabled a paradigm-shift away from highly tuned codes that force compliance with a bounding safety envelope, and towards codes regularly validated against routine measurements. To validate HELIOS, the 16 ATR operational cycles from late-2009 to present were modeled. The computed power distribution was compared against data collected by the ATR’s on-line power surveillance system. It was found that the ATR’s lobe-powers could be determined with ±10% accuracy. Also, the ATR’s cold startup shim configuration for each of these 16 cycles was estimated and compared against the reported critical position from the reactor log-book. HELIOS successfully predicted criticality within the tolerance set by the ATR startup procedure for 13 out of the 16 cycles. This is compared to 12 times for PDQ (without empirical adjustment). These findings, as well as other insights discussed in this report, suggest that HELIOS is highly suited for replacing PDQ for core safety assurance of the ATR. Furthermore, a modern verification and validation framework has been established that allows reactor and fuel performance data to be computed with a known degree of accuracy and stated uncertainty.

  4. Monitoring and Analysis of In-Pile Phenomena in Advanced Test Reactor using Acoustic Telemetry

    Energy Technology Data Exchange (ETDEWEB)

    Agarwal, Vivek [Idaho National Lab. (INL), Idaho Falls, ID (United States). Dept. of Human Factors, Controls, and Statistics; Smith, James A. [Idaho National Lab. (INL), Idaho Falls, ID (United States). Dept. of Fuel Performance and Design; Jewell, James Keith [Idaho National Lab. (INL), Idaho Falls, ID (United States). Dept. of Fuel Performance and Design

    2015-02-01

    The interior of a nuclear reactor presents a particularly harsh and challenging environment for both sensors and telemetry due to high temperatures and high fluxes of energetic and ionizing particles among the radioactive decay products. A number of research programs are developing acoustic-based sensing approach to take advantage of the acoustic transmission properties of reactor cores. Idaho National Laboratory has installed vibroacoustic receivers on and around the Advanced Test Reactor (ATR) containment vessel to take advantage of acoustically telemetered sensors such as thermoacoustic (TAC) transducers. The installation represents the first step in developing an acoustic telemetry infrastructure. This paper presents the theory of TAC, application of installed vibroacoustic receivers in monitoring the in-pile phenomena inside the ATR, and preliminary data processing results.

  5. A feasibility and optimization study to determine cooling time and burnup of advanced test reactor fuels using a nondestructive technique

    Energy Technology Data Exchange (ETDEWEB)

    Navarro, Jorge [Univ. of Utah, Salt Lake City, UT (United States)

    2013-12-01

    The goal of this study presented is to determine the best available non-destructive technique necessary to collect validation data as well as to determine burn-up and cooling time of the fuel elements onsite at the Advanced Test Reactor (ATR) canal. This study makes a recommendation of the viability of implementing a permanent fuel scanning system at the ATR canal and leads3 to the full design of a permanent fuel scan system. The study consisted at first in determining if it was possible and which equipment was necessary to collect useful spectra from ATR fuel elements at the canal adjacent to the reactor. Once it was establish that useful spectra can be obtained at the ATR canal the next step was to determine which detector and which configuration was better suited to predict burnup and cooling time of fuel elements non-destructively. Three different detectors of High Purity Germanium (HPGe), Lanthanum Bromide (LaBr3), and High Pressure Xenon (HPXe) in two system configurations of above and below the water pool were used during the study. The data collected and analyzed was used to create burnup and cooling time calibration prediction curves for ATR fuel. The next stage of the study was to determine which of the three detectors tested was better suited for the permanent system. From spectra taken and the calibration curves obtained, it was determined that although the HPGe detector yielded better results, a detector that could better withstand the harsh environment of the ATR canal was needed. The in-situ nature of the measurements required a rugged fuel scanning system, low in maintenance and easy to control system. Based on the ATR canal feasibility measurements and calibration results it was determined that the LaBr3 detector was the best alternative for canal in-situ measurements; however in order to enhance the quality of the spectra collected using this scintillator a deconvolution method was developed. Following the development of the deconvolution method

  6. Recent Advances in Contextuality Tests

    Science.gov (United States)

    Thompson, Jayne; Kurzyński, Paweł; Lee, Su-Yong; Soeda, Akihito; Kaszlikowski, Dagomir

    2016-07-01

    Our everyday experiences support the hypothesis that physical systems exist independently of the act of observation. Concordant theories are characterized by the objective realism assumption whereby the act of measurement simply reveals preexisting well-defined elements of reality. In stark contrast quantum mechanics portrays a world in which reality loses its objectivity and is in fact created by observation. Quantum contextuality as first discovered by Bell [1] and Kochen-Specker [2] captures aspects of this philosophical clash between classical and quantum descriptions of the world. Here we briefly summarize some of the more recent advances in the field of quantum contextuality. We approach quantum contextuality through its close relation to Bell type nonlocal scenarios and highlight some of the rapidly developing tests and experimental implementations.

  7. Status of ATR-A1 irradiation experiment on vanadium alloys and low-activation steels

    Energy Technology Data Exchange (ETDEWEB)

    Tsai, H.; Strain, R.V.; Gomes, I.; Smith, D.L. [Argonne National Lab., IL (United States); Matsui, H. [Tohoku Univ. (Japan)

    1996-10-01

    The ATR-A1 irradiation experiment was a collaborative U.S./Japan effort to study at low temperature the effects of neutron damage on vanadium alloys. The experiment also contained a limited quantity of low-activation ferritic steel specimens from Japan as part of the collaboration agreement. The irradiation started in the Advanced Test Reactor (ATR) on November 30, 1995, and ended as planned on May 5, 1996. Total exposure was 132.9 effective full power days (EFPDs) and estimated neutron damage in the vanadium was 4.7 dpa. The vehicle has been discharged from the ATR core and is scheduled to be disassembled in the next reporting period.

  8. TEMPERATURE MONITORING OPTIONS AVAILABLE AT THE IDAHO NATIONAL LABORATORY ADVANCED TEST REACTOR

    Energy Technology Data Exchange (ETDEWEB)

    J.E. Daw; J.L. Rempe; D.L. Knudson; T. Unruh; B.M. Chase; K.L Davis

    2012-03-01

    As part of the Advanced Test Reactor National Scientific User Facility (ATR NSUF) program, the Idaho National Laboratory (INL) has developed in-house capabilities to fabricate, test, and qualify new and enhanced sensors for irradiation testing. To meet recent customer requests, an array of temperature monitoring options is now available to ATR users. The method selected is determined by test requirements and budget. Melt wires are the simplest and least expensive option for monitoring temperature. INL has recently verified the melting temperature of a collection of materials with melt temperatures ranging from 100 to 1000 C with a differential scanning calorimeter installed at INL’s High Temperature Test Laboratory (HTTL). INL encapsulates these melt wires in quartz or metal tubes. In the case of quartz tubes, multiple wires can be encapsulated in a single 1.6 mm diameter tube. The second option available to ATR users is a silicon carbide temperature monitor. The benefit of this option is that a single small monitor (typically 1 mm x 1 mm x 10 mm or 1 mm diameter x 10 mm length) can be used to detect peak irradiation temperatures ranging from 200 to 800 C. Equipment has been installed at INL’s HTTL to complete post-irradiation resistivity measurements on SiC monitors, a technique that has been found to yield the most accurate temperatures from these monitors. For instrumented tests, thermocouples may be used. In addition to Type-K and Type-N thermocouples, a High Temperature Irradiation Resistant ThermoCouple (HTIR-TC) was developed at the HTTL that contains commercially-available doped molybdenum paired with a niobium alloy thermoelements. Long duration high temperature tests, in furnaces and in the ATR and other MTRs, demonstrate that the HTIR-TC is accurate up to 1800 C and insensitive to thermal neutron interactions. Thus, degradation observed at temperatures above 1100 C with Type K and N thermocouples and decalibration due to transmutation with tungsten

  9. ATR LEU Monolithic Foil-Type Fuel with Integral Cladding Burnable Absorber – Neutronics Performance Evaluation

    Energy Technology Data Exchange (ETDEWEB)

    Gray Chang

    2012-03-01

    The Advanced Test Reactor (ATR), currently operating in the United States, is used for material testing at very high neutron fluxes. Powered with highly enriched uranium (HEU), the ATR has a maximum thermal power rating of 250 MWth. Because of the large test volumes located in high flux areas, the ATR is an ideal candidate for assessing the feasibility of converting HEU driven reactor cores to low-enriched uranium (LEU) cores. The burnable absorber - 10B, was added in the inner and outer plates to reduce the initial excess reactivity, and to improve the peak ratio of the inner/outer heat flux. The present work investigates the LEU Monolithic foil-type fuel with 10B Integral Cladding Burnable Absorber (ICBA) design and evaluates the subsequent neutronics operating effects of this proposed fuel designs. The proposed LEU fuel specification in this work is directly related to both the RERTR LEU Development Program and the Advanced Test Reactor (ATR) LEU Conversion Project at Idaho National Laboratory (INL).

  10. Verification tests for CANDU advanced fuel

    Energy Technology Data Exchange (ETDEWEB)

    Chung, Chang Hwan; Chang, S.K.; Hong, S.D. [and others

    1997-07-01

    For the development of a CANDU advanced fuel, the CANFLEX-NU fuel bundles were tested under reactor operating conditions at the CANDU-Hot test loop. This report describes test results and test methods in the performance verification tests for the CANFLEX-NU bundle design. The main items described in the report are as follows. - Fuel bundle cross-flow test - Endurance fretting/vibration test - Freon CHF test - Production of technical document. (author). 25 refs., 45 tabs., 46 figs.

  11. AGR-3/4 Final Data Qualification Report for ATR Cycles 151A through 155B-1

    Energy Technology Data Exchange (ETDEWEB)

    Pham, Binh T. [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2015-03-01

    This report provides the qualification status of experimental data for the entire Advanced Gas Reactor 3/4 (AGR 3/4) fuel irradiation. AGR-3/4 is the third in a series of planned irradiation experiments conducted in the Advanced Test Reactor (ATR) at Idaho National Laboratory (INL) for the AGR Fuel Development and Qualification Program, which supports development of the advanced reactor technology under the INL ART Technology Development Office (TDO). The main objective of AGR-3/4 irradiation is to provide a known source of fission products for subsequent transport through compact matrix and structural graphite materials due to the presence of designed-to-fail fuel particles. Full power irradiation of the AGR 3/4 test began on December 14, 2011 (ATR Cycle 151A), and was completed on April 12, 2014 (end of ATR Cycle 155B) after 369.1 effective full power days of irradiation. The AGR-3/4 test was in the reactor core for eight of the ten ATR cycles between 151A and 155B. During the unplanned outage cycle, 153A, the experiment was removed from the ATR northeast flux trap (NEFT) location and stored in the ATR canal. This was to prevent overheating of fuel compacts due to higher than normal ATR power during the subsequent Powered Axial Locator Mechanism cycle, 153B. The AGR 3/4 test was inserted back into the ATR NEFT location during the outage of ATR Cycle 154A on April 26, 2013. Therefore, the AGR-3/4 irradiation data received during these 2 cycles (153A and 153B) are irrelevant and their qualification status isnot included in this report. Additionally, during ATR Cycle 152A the ATR core ran at low power for a short enough duration that the irradiation data are not used for physics and thermal calculations. However, the qualification status of irradiation data for this cycle is still covered in this report. As a result, this report includes data from 8 ATR Cycles: 151A, 151B, 152A, 152B, 154A, 154B, 155A, and 155B, as recorded in the Nuclear Data Management and

  12. Advanced Gas Reactor (AGR)-5/6/7 Fuel Irradiation Experiments in the Advanced Test Reactor

    Energy Technology Data Exchange (ETDEWEB)

    A. Joseph Palmer; David A. Petti; S. Blaine Grover

    2014-04-01

    The United States Department of Energy’s Very High Temperature Reactor (VHTR) Advanced Gas Reactor (AGR) Fuel Development and Qualification Program will be irradiating up to seven separate low enriched uranium (LEU) tri-isotopic (TRISO) particle fuel (in compact form) experiments in the Advanced Test Reactor (ATR) located at the Idaho National Laboratory (INL). These irradiations and fuel development are being accomplished to support development of the next generation reactors in the United States. The goals of the irradiation experiments are to provide irradiation performance data to support fuel process development, to qualify fuel for normal operating conditions, to support development and validation of fuel performance and fission product transport models and codes, and to provide irradiated fuel and materials for post irradiation examination (PIE) and safety testing. The experiments, which each consist of at least five separate capsules, are being irradiated in an inert sweep gas atmosphere with individual on-line temperature monitoring and control of each capsule. The sweep gases also have on-line fission product monitoring the effluent from each capsule to track performance of the fuel during irradiation. The first two experiments (designated AGR-1 and AGR-2), have been completed. The third and fourth experiments have been combined into a single experiment designated AGR-3/4, which started its irradiation in December 2011 and is currently scheduled to be completed in April 2014. The design of the fuel qualification experiment, designated AGR-5/6/7, is well underway and incorporates lessons learned from the three previous experiments. Various design issues will be discussed with particular details related to selection of thermometry.

  13. Analysis of the ATR fuel element swaging process

    Energy Technology Data Exchange (ETDEWEB)

    Richins, W.D.; Miller, G.K.

    1995-12-01

    This report documents a detailed evaluation of the swaging process used to connect fuel plates to side plates in Advanced Test Reactor (ATR) fuel elements. The swaging is a mechanical process that begins with fitting a fuel plate into grooves in the side plates. Once a fuel plate is positioned, a lip on each of two side plate grooves is pressed into the fuel plate using swaging wheels to form the joints. Each connection must have a specified strength (measured in terms, of a pullout force capacity) to assure that these joints do not fail during reactor operation. The purpose of this study is to analyze the swaging process and associated procedural controls, and to provide recommendations to assure that the manufacturing process produces swaged connections that meet the minimum strength requirement. The current fuel element manufacturer, Babcock and Wilcox (B&W) of Lynchburg, Virginia, follows established procedures that include quality inspections and process controls in swaging these connections. The procedures have been approved by Lockheed Martin Idaho Technologies and are designed to assure repeatability of the process and structural integrity of each joint. Prior to July 1994, ATR fuel elements were placed in the Hydraulic Test Facility (HTF) at the Idaho National Engineering Laboratory (AGNAIL), Test Reactor Area (TRA) for application of Boehmite (an aluminum oxide) film and for checking structural integrity before placement of the elements into the ATR. The results presented in this report demonstrate that the pullout strength of the swaged connections is assured by the current manufacturing process (with several recommended enhancements) without the need for- testing each element in the HTF.

  14. Submission of FeCrAl Feedstock for Support of AFC ATR-2 Irradiations

    Energy Technology Data Exchange (ETDEWEB)

    Field, Kevin G. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Barrett, Kristine E. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Sun, Zhiqian [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Yamamoto, Yukinori [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2016-09-16

    The Advanced Test Reactor (ATR) is currently being used to test accident tolerant fuel (ATF) forms destined for commercial nuclear power plant deployment. One irradiation program using the ATR for ATF concepts, Accident Tolerant Fuel-2 (ATF-2), is a water loop irradiation test using miniaturized fuel pins as test articles. This complicated testing configuration requires a series of pre-test experiments and verification including a flowing loop autoclave test and a sensor qualification test (SQT) prior to full test train deployment within the ATR. In support of the ATF-2 irradiation program, Oak Ridge National Laboratory (ORNL) has supplied two different Generation II FeCrAl alloys in rod stock form to Idaho National Laboratory (INL). These rods will be machined into dummy pins for deployment in the autoclave test and SQT. Post-test analysis of the dummy pins will provide initial insight into the performance of Generation II FeCrAl alloys in the ATF-2 irradiation experiment as well as within a commercial nuclear reactor.

  15. Submission of FeCrAl feedstock for support of AFC ATR-2 Irradiations

    Energy Technology Data Exchange (ETDEWEB)

    Field, Kevin G [ORNL; Barrett, Kristine E. [Idaho National Laboratory (INL); Sun, Zhiqian [ORNL; Yamamoto, Yukinori [ORNL

    2016-09-01

    The Advanced Test Reactor (ATR) is currently being used to test accident tolerant fuel (ATF) forms destined for commercial nuclear power plant deployment. One irradiation program using the ATR for ATF concepts, Accident Tolerant Fuel-2 (ATF-2), is a water loop irradiation test using miniaturized fuel pins as test articles. This complicated testing configuration requires a series of pre-test experiments and verification including a flowing loop autoclave test and a sensor qualification test (SQT) prior to full test train deployment within the ATR. In support of the ATF-2 irradiation program, Oak Ridge National Laboratory (ORNL) has supplied two different Generation II FeCrAl alloys in rod stock form to Idaho National Laboratory (INL). These rods will be machined into dummy pins for deployment in the autoclave test and SQT. Post-test analysis of the dummy pins will provide initial insight into the performance of Generation II FeCrAl alloys in the ATF-2 irradiation experiment as well as within a commercial nuclear reactor.

  16. Testing of Haar-Like Feature in Region of Interest Detection for Automated Target Recognition (ATR) System

    Science.gov (United States)

    Zhang, Yuhan; Lu, Dr. Thomas

    2010-01-01

    The objectives of this project were to develop a ROI (Region of Interest) detector using Haar-like feature similar to the face detection in Intel's OpenCV library, implement it in Matlab code, and test the performance of the new ROI detector against the existing ROI detector that uses Optimal Trade-off Maximum Average Correlation Height filter (OTMACH). The ROI detector included 3 parts: 1, Automated Haar-like feature selection in finding a small set of the most relevant Haar-like features for detecting ROIs that contained a target. 2, Having the small set of Haar-like features from the last step, a neural network needed to be trained to recognize ROIs with targets by taking the Haar-like features as inputs. 3, using the trained neural network from the last step, a filtering method needed to be developed to process the neural network responses into a small set of regions of interests. This needed to be coded in Matlab. All the 3 parts needed to be coded in Matlab. The parameters in the detector needed to be trained by machine learning and tested with specific datasets. Since OpenCV library and Haar-like feature were not available in Matlab, the Haar-like feature calculation needed to be implemented in Matlab. The codes for Adaptive Boosting and max/min filters in Matlab could to be found from the Internet but needed to be integrated to serve the purpose of this project. The performance of the new detector was tested by comparing the accuracy and the speed of the new detector against the existing OTMACH detector. The speed was referred as the average speed to find the regions of interests in an image. The accuracy was measured by the number of false positives (false alarms) at the same detection rate between the two detectors.

  17. Process Knowledge Summary Report for Advanced Test Reactor Complex Contact-Handled Transuranic Waste Drum TRA010029

    Energy Technology Data Exchange (ETDEWEB)

    B. R. Adams; R. P. Grant; P. R. Smith; J. L. Weisgerber

    2013-09-01

    This Process Knowledge Summary Report summarizes information collected to satisfy the transportation and waste acceptance requirements for the transfer of one drum containing contact-handled transuranic (TRU) actinide standards generated by the Idaho National Laboratory at the Advanced Test Reactor (ATR) Complex to the Advanced Mixed Waste Treatment Project (AMWTP) for storage and subsequent shipment to the Waste Isolation Pilot Plant for final disposal. The drum (i.e., Integrated Waste Tracking System Bar Code Number TRA010029) is currently stored at the Materials and Fuels Complex. The information collected includes documentation that addresses the requirements for AMWTP and applicable sections of their Resource Conservation and Recovery Act permits for receipt and disposal of this TRU waste generated from ATR. This Process Knowledge Summary Report includes information regarding, but not limited to, the generation process, the physical form, radiological characteristics, and chemical contaminants of the TRU waste, prohibited items, and packaging configuration. This report, along with the referenced supporting documents, will create a defensible and auditable record for this TRU waste originating from ATR.

  18. The Next Generation Nuclear Plant Graphite Creep Experiment Irradiation in the Advanced Test Reactor

    Energy Technology Data Exchange (ETDEWEB)

    Blaine Grover

    2010-10-01

    The United States Department of Energy’s Next Generation Nuclear Plant (NGNP) Program will be irradiating six gas reactor graphite creep experiments in the Advanced Test Reactor (ATR) located at the Idaho National Laboratory (INL). The ATR has a long history of irradiation testing in support of reactor development and the INL has been designated as the United States Department of Energy’s lead laboratory for nuclear energy development. The ATR is one of the world’s premiere test reactors for performing long term, high flux, and/or large volume irradiation test programs. These graphite irradiations are being accomplished to support development of the next generation reactors in the United States. The graphite experiments will be irradiated over the next six to eight years to support development of a graphite irradiation performance data base on the new nuclear grade graphites now available for use in high temperature gas reactors. The goals of the irradiation experiments are to obtain irradiation performance data, including irradiation creep, at different temperatures and loading conditions to support design of the Next Generation Nuclear Plant (NGNP) Very High Temperature Gas Reactor, as well as other future gas reactors. The experiments will each consist of a single capsule that will contain six stacks of graphite specimens, with half of the graphite specimens in each stack under a compressive load, while the other half of the specimens will not be subjected to a compressive load during irradiation. The six stacks will have differing compressive loads applied to the top half of each pair of specimen stacks, while a seventh stack will not have a compressive load. The specimens will be irradiated in an inert sweep gas atmosphere with on-line temperature and compressive load monitoring and control. There will also be the capability of sampling the sweep gas effluent to determine if any oxidation or off-gassing of the specimens occurs during initial start-up of

  19. Advanced Test Reactor Core Modeling Update Project Annual Report for Fiscal Year 2011

    Energy Technology Data Exchange (ETDEWEB)

    David W. Nigg; Devin A. Steuhm

    2011-09-01

    Legacy computational reactor physics software tools and protocols currently used for support of Advanced Test Reactor (ATR) core fuel management and safety assurance and, to some extent, experiment management are obsolete, inconsistent with the state of modern nuclear engineering practice, and are becoming increasingly difficult to properly verify and validate (V&V). Furthermore, the legacy staff knowledge required for application of these tools and protocols from the 1960s and 1970s is rapidly being lost due to staff turnover and retirements. In 2009 the Idaho National Laboratory (INL) initiated a focused effort to address this situation through the introduction of modern high-fidelity computational software and protocols, with appropriate V&V, within the next 3-4 years via the ATR Core Modeling and Simulation and V&V Update (or 'Core Modeling Update') Project. This aggressive computational and experimental campaign will have a broad strategic impact on the operation of the ATR, both in terms of improved computational efficiency and accuracy for support of ongoing DOE programs as well as in terms of national and international recognition of the ATR National Scientific User Facility (NSUF). The ATR Core Modeling Update Project, targeted for full implementation in phase with the anticipated ATR Core Internals Changeout (CIC) in the 2014 time frame, began during the last quarter of Fiscal Year 2009, and has just completed its first full year. Key accomplishments so far have encompassed both computational as well as experimental work. A new suite of stochastic and deterministic transport theory based reactor physics codes and their supporting nuclear data libraries (SCALE, KENO-6, HELIOS, NEWT, and ATTILA) have been installed at the INL under various permanent sitewide license agreements and corresponding baseline models of the ATR and ATRC are now operational, demonstrating the basic feasibility of these code packages for their intended purpose. Furthermore

  20. Reactor Physics Scoping and Characterization Study on Implementation of TRIGA Fuel in the Advanced Test Reactor

    Energy Technology Data Exchange (ETDEWEB)

    Jennifer Lyons; Wade R. Marcum; Mark D. DeHart; Sean R. Morrell

    2014-01-01

    The Advanced Test Reactor (ATR), under the Reduced Enrichment for Research and Test Reactors (RERTR) Program and the Global Threat Reduction Initiative (GTRI), is conducting feasibility studies for the conversion of its fuel from a highly enriched uranium (HEU) composition to a low enriched uranium (LEU) composition. These studies have considered a wide variety of LEU plate-type fuels to replace the current HEU fuel. Continuing to investigate potential alternatives to the present HEU fuel form, this study presents a preliminary analysis of TRIGA® fuel within the current ATR fuel envelopes and compares it to the functional requirements delineated by the Naval Reactors Program, which includes: greater than 4.8E+14 fissions/s/g of 235U, a fast to thermal neutron flux ratio that is less than 5% deviation of its current value, a constant cycle power within the corner lobes, and an operational cycle length of 56 days at 120 MW. Other parameters outside those put forth by the Naval Reactors Program which are investigated herein include axial and radial power profiles, effective delayed neutron fraction, and mean neutron generation time.

  1. Improving the AGR Fuel Testing Power Density Profile Versus Irradiation-Time in the Advanced Test Reactor

    Energy Technology Data Exchange (ETDEWEB)

    Gray S. Chang; David A. Petti; John T. Maki; Misti A. Lillo

    2009-05-01

    The Very High Temperature gas-cooled Reactor (VHTR), which is currently being developed, achieves simplification of safety through reliance on ceramic-coated fuel particles. Each TRISO-coated fuel particle has its own containment which serves as the principal barrier against radionuclide release under normal operating and accident conditions. These fuel particles, in the form of graphite fuel compacts, are currently undergoing a series of irradiation tests in the Advanced Test Reactor (ATR) at the Idaho National Laboratory (INL) to support the Advanced Gas-Cooled Reactor (AGR) fuel qualification program. A representive coated fuel particle with an 235U enrichment of 19.8 wt% was used in this analysis. The fuel burnup analysis tool used to perform the neutronics study reported herein, couples the Monte Carlo transport code MCNP, with the radioactive decay and burnup code ORIGEN2. The fuel burnup methodology known as Monte-Carlo with ORIGEN2 (MCWO) was used to evaluate the AGR experiment assembly and demonstrate compliance with ATR safety requirements. For the AGR graphite fuel compacts, the MCWO-calculated fission power density (FPD) due to neutron fission in 235U is an important design parameter. One of the more important AGR fuel testing requirements is to maintain the peak fuel compact temperature close to 1250°C throughout the proposed irradiation campaign of 550 effective full power days (EFPDs). Based on the MCWO-calculated FPD, a fixed gas gap size was designed to allow regulation of the fuel compact temperatures throughout the entire fuel irradiation campaign by filling the gap with a mixture of helium and neon gases. The chosen fixed gas gap can only regulate the peak fuel compact temperature in the desired range during the irradiation test if the ratio of the peak power density to the time-dependent low power density (P/T) at 550 EFPDs is less than 2.5. However, given the near constant neutron flux within the ATR driver core and the depletion of 235U in

  2. Recent applications of ATR FTIR spectroscopy and imaging to proteins.

    Science.gov (United States)

    Glassford, Stefanie E; Byrne, Bernadette; Kazarian, Sergei G

    2013-12-01

    Attenuated Total Reflection (ATR) Fourier Transform Infrared (FTIR) spectroscopy is a label-free, non-destructive analytical technique that can be used extensively to study a wide variety of different molecules in a range of different conditions. The aim of this review is to discuss and highlight the recent advances in the applications of ATR FTIR spectroscopic imaging to proteins. It briefly covers the basic principles of ATR FTIR spectroscopy and ATR FTIR spectroscopic imaging as well as their advantages to the study of proteins compared to other techniques and other forms of FTIR spectroscopy. It will then go on to examine the advances that have been made within the field over the last several years, particularly the use of ATR FTIR spectroscopy for the understanding and development of protein interaction with surfaces. Additionally, the growing potential of Surface Enhanced Infrared Spectroscopy (SEIRAS) within this area of applications will be discussed. The review includes the applications of ATR FTIR imaging to protein crystallisation and for high-throughput studies, highlighting the future potential of the technology within the field of protein structural studies and beyond.

  3. Neural network setpoint control of an advanced test reactor experiment loop simulation

    Energy Technology Data Exchange (ETDEWEB)

    Cordes, G.A.; Bryan, S.R.; Powell, R.H.; Chick, D.R.

    1990-09-01

    This report describes the design, implementation, and application of artificial neural networks to achieve temperature and flow rate control for a simulation of a typical experiment loop in the Advanced Test Reactor (ATR) located at the Idaho National Engineering Laboratory (INEL). The goal of the project was to research multivariate, nonlinear control using neural networks. A loop simulation code was adapted for the project and used to create a training set and test the neural network controller for comparison with the existing loop controllers. The results for three neural network designs are documented and compared with existing loop controller action. The neural network was shown to be as accurate at loop control as the classical controllers in the operating region represented by the training set. 9 refs., 28 figs., 2 tabs.

  4. ATR-A1 irradiation experiment on vanadium alloys and low activation steels

    Energy Technology Data Exchange (ETDEWEB)

    Tasi, H.; Strain, R.V.; Gomes, I.; Hins, A.G.; Smith, D.L.

    1996-04-01

    To study the mechanical properties of vanadium alloys under neutron irradiation at low temperatures, an experiment was designed and constructed for irradiation in the Advanced Test Reactor (ATR). The experiment contained Charpy, tensile, compact tension, TEM, and creep specimens of vanadium alloys. It also contained limited low-activation ferritic steel specimens as part of the collaborative agreement with Monbusho of Japan. The design irradiation temperatures for the vanadium alloy specimens in the experiment are {approx}200 and 300{degrees}C, achieved with passive gap-gap sizing and fill gas blending. To mitigate vanadium-to-chromium transmutation from the thermal neutron flux, the test specimens are contained inside gadolinium flux filters. All specimens are lithium-bonded. The irradiation started in Cycle 108A (December 3, 1995) and is expected to have a duration of three ATR cycles and a peak influence of 4.4 dpa.

  5. Waste Heat Recovery from the Advanced Test Reactor Secondary Coolant Loop

    Energy Technology Data Exchange (ETDEWEB)

    Donna Post Guillen

    2012-11-01

    This study investigated the feasibility of using a waste heat recovery system (WHRS) to recover heat from the Advanced Test Reactor (ATR) secondary coolant system (SCS). This heat would be used to preheat air for space heating of the reactor building, thus reducing energy consumption, carbon footprint, and energy costs. Currently, the waste heat from the reactor is rejected to the atmosphere via a four-cell, induced-draft cooling tower. Potential energy and cost savings are 929 kW and $285K/yr. The WHRS would extract a tertiary coolant stream from the SCS loop and pump it to a new plate and frame heat exchanger, from which the heat would be transferred to a glycol loop for preheating outdoor air supplied to the heating and ventilation system. The use of glycol was proposed to avoid the freezing issues that plagued and ultimately caused the failure of a WHRS installed at the ATR in the 1980s. This study assessed the potential installation of a new WHRS for technical, logistical, and economic feasibility.

  6. Advanced Mechanical Testing of Sandwich Materials

    DEFF Research Database (Denmark)

    Hayman, Brian; Berggreen, Christian; Jenstrup, Claus

    2008-01-01

    An advanced digital optical system has been used to measure surface strains on sandwich face and core specimens tested in a project concerned with improved criteria for designing sandwich X-joints. The face sheet specimens were of glass reinforced polyester and were tested in tension. The core...... specimens were of PVC foam and were tested in compression. The tests were performed in order to validate the use of the measurement system on these materials and to obtain material data for use in numerical simulations. While some limitations were identified, the optical system performed well and appears...

  7. Advances in diagnostic testing for Alzheimer disease.

    Science.gov (United States)

    Schindler, Suzanne E; McConathy, Jonathan; Ances, Beau M; Diamond, Marc I

    2013-01-01

    The diagnosis of Alzheimer disease (AD) dementia is based primarily on the clinical history and examination, but advances in understanding the pathophysiology of AD have led to new diagnostic methods. When used appropriately, the tests can provide strong positive or negative evidence AD dementia. This article described which patients may benefit from additional testing using Cerebrospinal Fluid (CSF) biomarkers, amyloid imaging, quantitative structural magnetic resonance imaging (MRI), and fluoro-deoxyglucose positron emission tomography (FDG-PET).

  8. Advanced Demonstration and Test Reactor Options Study

    Energy Technology Data Exchange (ETDEWEB)

    Petti, David Andrew [Idaho National Lab. (INL), Idaho Falls, ID (United States); Hill, R. [Argonne National Lab. (ANL), Argonne, IL (United States); Gehin, J. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Gougar, Hans David [Idaho National Lab. (INL), Idaho Falls, ID (United States); Strydom, Gerhard [Idaho National Lab. (INL), Idaho Falls, ID (United States); Heidet, F. [Argonne National Lab. (ANL), Argonne, IL (United States); Kinsey, J. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Grandy, Christopher [Argonne National Lab. (ANL), Argonne, IL (United States); Qualls, A. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Brown, Nicholas [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Powers, J. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Hoffman, E. [Argonne National Lab. (ANL), Argonne, IL (United States); Croson, D. [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2017-01-01

    Global efforts to address climate change will require large-scale decarbonization of energy production in the United States and elsewhere. Nuclear power already provides 20% of electricity production in the United States (U.S.) and is increasing in countries undergoing rapid growth around the world. Because reliable, grid-stabilizing, low emission electricity generation, energy security, and energy resource diversity will be increasingly valued, nuclear power’s share of electricity production has a potential to grow. In addition, there are non electricity applications (e.g., process heat, desalination, hydrogen production) that could be better served by advanced nuclear systems. Thus, the timely development, demonstration, and commercialization of advanced nuclear reactors could diversify the nuclear technologies available and offer attractive technology options to expand the impact of nuclear energy for electricity generation and non-electricity missions. The purpose of this planning study is to provide transparent and defensible technology options for a test and/or demonstration reactor(s) to be built to support public policy, innovation and long term commercialization within the context of the Department of Energy’s (DOE’s) broader commitment to pursuing an “all of the above” clean energy strategy and associated time lines. This planning study includes identification of the key features and timing needed for advanced test or demonstration reactors to support research, development, and technology demonstration leading to the commercialization of power plants built upon these advanced reactor platforms. This planning study is consistent with the Congressional language contained within the fiscal year 2015 appropriation that directed the DOE to conduct a planning study to evaluate “advanced reactor technology options, capabilities, and requirements within the context of national needs and public policy to support innovation in nuclear energy

  9. Advanced Materials Laboratory User Test Planning Guide

    Science.gov (United States)

    Orndoff, Evelyne

    2012-01-01

    Test process, milestones and inputs are unknowns to first-time users of the Advanced Materials Laboratory. The User Test Planning Guide aids in establishing expectations for both NASA and non-NASA facility customers. The potential audience for this guide includes both internal and commercial spaceflight hardware/software developers. It is intended to assist their test engineering personnel in test planning and execution. Material covered includes a roadmap of the test process, roles and responsibilities of facility and user, major milestones, facility capabilities, and inputs required by the facility. Samples of deliverables, test article interfaces, and inputs necessary to define test scope, cost, and schedule are included as an appendix to the guide.

  10. Preliminary Results of an On-Line, Multi-Spectrometer Fission Product Monitoring System to Support Advanced Gas Reactor Fuel Testing and Qualification in the Advanced Test Reactor at the Idaho National Laboratory

    Energy Technology Data Exchange (ETDEWEB)

    Dawn M. Scates; John K. Hartwell; John B. Walter; Mark W. Drigert

    2007-10-01

    The Advanced Gas Reactor -1 (AGR-1) experiment is the first experiment in a series of eight separate low enriched uranium (LEU) oxycarbide (UCO) tri-isotropic (TRISO) particle fuel (in compact form) experiments scheduled for placement in the Advanced Test Reactor (ATR) located at the Idaho National Laboratory (INL). The experiment began irradiation in the ATR with a cycle that reached full power on December 26, 2006 and will continue irradiation for about 2.5 years. During this time six separate capsules, will be irradiated in an inert sweep gas atmosphere with individual on-line fission product monitoring on its effluent to track performance of the fuel in each individual capsule during irradiation. The goals of the irradiation experiment is to provide irradiation performance data to support fuel process development, to qualify fuel for normal operating conditions, to support development and validation of fuel, and to provide irradiated fuel and materials for post irradiation examination (PIE) and safety testing. This paper presents the preliminary test details of the fuel performance, as measured by the control and acquisition software.

  11. Future Transient Testing of Advanced Fuels

    Energy Technology Data Exchange (ETDEWEB)

    Jon Carmack

    2009-09-01

    The transient in-reactor fuels testing workshop was held on May 4–5, 2009 at Idaho National Laboratory. The purpose of this meeting was to provide a forum where technical experts in transient testing of nuclear fuels could meet directly with technical instrumentation experts and nuclear fuel modeling and simulation experts to discuss needed advancements in transient testing to support a basic understanding of nuclear fuel behavior under off-normal conditions. The workshop was attended by representatives from Commissariat à l'Énergie Atomique CEA, Japanese Atomic Energy Agency (JAEA), Department of Energy (DOE), AREVA, General Electric – Global Nuclear Fuels (GE-GNF), Westinghouse, Electric Power Research Institute (EPRI), universities, and several DOE national laboratories. Transient testing of fuels and materials generates information required for advanced fuels in future nuclear power plants. Future nuclear power plants will rely heavily on advanced computer modeling and simulation that describes fuel behavior under off-normal conditions. TREAT is an ideal facility for this testing because of its flexibility, proven operation and material condition. The opportunity exists to develop advanced instrumentation and data collection that can support modeling and simulation needs much better than was possible in the past. In order to take advantage of these opportunities, test programs must be carefully designed to yield basic information to support modeling before conducting integral performance tests. An early start of TREAT and operation at low power would provide significant dividends in training, development of instrumentation, and checkout of reactor systems. Early start of TREAT (2015) is needed to support the requirements of potential users of TREAT and include the testing of full length fuel irradiated in the FFTF reactor. The capabilities provided by TREAT are needed for the development of nuclear power and the following benefits will be realized by

  12. Mastering Kali Linux for advanced penetration testing

    CERN Document Server

    Beggs, Robert W

    2014-01-01

    This book provides an overview of the kill chain approach to penetration testing, and then focuses on using Kali Linux to provide examples of how this methodology is applied in the real world. After describing the underlying concepts, step-by-step examples are provided that use selected tools to demonstrate the techniques. If you are an IT professional or a security consultant who wants to maximize the success of your network testing using some of the advanced features of Kali Linux, then this book is for you. This book will teach you how to become an expert in the pre-engagement, management,

  13. Design of the Next Generation Nuclear Plant Graphite Creep Experiments for Irradiation in the Advanced Test Reactor

    Energy Technology Data Exchange (ETDEWEB)

    S. Blaine Grover

    2009-05-01

    The United States Department of Energy’s Next Generation Nuclear Plant (NGNP) Program will be irradiating six gas reactor graphite creep experiments in the Advanced Test Reactor (ATR) located at the Idaho National Laboratory (INL). The ATR has a long history of irradiation testing in support of reactor development and the INL has been designated as the new United States Department of Energy’s lead laboratory for nuclear energy development. The ATR is one of the world’s premiere test reactors for performing long term, high flux, and/or large volume irradiation test programs. These graphite irradiations are being accomplished to support development of the next generation reactors in the United States. The graphite experiments will be irradiated over the next six to eight years to support development of a graphite irradiation performance data base on the new nuclear grade graphites now available for use in high temperature gas reactors. The goals of the irradiation experiments are to obtain irradiation performance data at different temperatures and loading conditions to support design of the Next Generation Nuclear Plant Very High Temperature Gas Reactor, as well as other future gas reactors. The experiments will each consist of a single capsule that will contain seven separate stacks of graphite specimens. Six of the specimen stacks will have half of their graphite specimens under a compressive load, while the other half of the specimens will not be subjected to a compressive load during irradiation. The six stacks will be organized into pairs with a different compressive load being applied to the top half of each pair of specimen stacks. The seventh stack will not have a compressive load on the graphite specimens during irradiation. The specimens will be irradiated in an inert sweep gas atmosphere with on-line temperature and compressive load monitoring and control. There will also be the capability of sampling the sweep gas effluent to determine if any

  14. Mixed oxide fuels testing in the advanced test reactor to support plutonium disposition

    Energy Technology Data Exchange (ETDEWEB)

    Ryskamp, J.M.; Sterbentz, J.W.; Chang, G.S. [and others

    1995-09-01

    An intense worldwide effort is now under way to find means of reducing the stockpile of weapons-grade plutonium. One of the most attractive solutions would be to use WGPu as fuel in existing light water reactors (LWRs) in the form of mixed oxide (MOX) fuel - i.e., plutonia (PUO{sub 2}) mixed with urania (UO{sub 2}). Before U.S. reactors could be used for this purpose, their operating licenses would have to be amended. Numerous technical issues must be resolved before LWR operating licenses can be amended to allow the use of MOX fuel. These issues include the following: (1) MOX fuel fabrication process verification, (2) Whether and how to use burnable poisons to depress MOX fuel initial reactivity, which is higher than that of urania, (3) The effects of WGPu isotopic composition, (4) The feasibility of loading MOX fuel with plutonia content up to 7% by weight, (5) The effects of americium and gallium in WGPu, (6) Fission gas release from MOX fuel pellets made from WGPu, (7) Fuel/cladding gap closure, (8) The effects of power cycling and off-normal events on fuel integrity, (9) Development of radial distributions of burnup and fission products, (10) Power spiking near the interfaces of MOX and urania fuel assemblies, and (11) Fuel performance code validation. We have performed calculations to show that the use of hafnium shrouds can produce spectrum adjustments that will bring the flux spectrum in ATR test loops into a good approximation to the spectrum anticipated in a commercial LWR containing MOX fuel while allowing operation of the test fuel assemblies near their optimum values of linear heat generation rate. The ATR would be a nearly ideal test bed for developing data needed to support applications to license LWRs for operation with MOX fuel made from weapons-grade plutonium. The requirements for planning and implementing a test program in the ATR have been identified.

  15. Bistatic SAR ATR

    OpenAIRE

    Mishra, Amit Kumar; Mulgrew, Bernard

    2010-01-01

    With the present revival of interest in bistatic radar systems, research in that area has gained momentum. Given some of the strategic advantages for a bistatic configuration, and tech- nological advances in the past few years, large-scale implementation of the bistatic systems is a scope for the near future. If the bistatic systems are to replace the monostatic systems (at least par- tially), then all the existing usages of a monostatic system should be manageable in a bistatic system. A det...

  16. Advanced burner test reactor preconceptual design report.

    Energy Technology Data Exchange (ETDEWEB)

    Chang, Y. I.; Finck, P. J.; Grandy, C.; Cahalan, J.; Deitrich, L.; Dunn, F.; Fallin, D.; Farmer, M.; Fanning, T.; Kim, T.; Krajtl, L.; Lomperski, S.; Moisseytsev, A.; Momozaki, Y.; Sienicki, J.; Park, Y.; Tang, Y.; Reed, C.; Tzanos, C; Wiedmeyer, S.; Yang, W.; Chikazawa, Y.; JAEA

    2008-12-16

    The goals of the Global Nuclear Energy Partnership (GNEP) are to expand the use of nuclear energy to meet increasing global energy demand, to address nuclear waste management concerns and to promote non-proliferation. Implementation of the GNEP requires development and demonstration of three major technologies: (1) Light water reactor (LWR) spent fuel separations technologies that will recover transuranics to be recycled for fuel but not separate plutonium from other transuranics, thereby providing proliferation-resistance; (2) Advanced Burner Reactors (ABRs) based on a fast spectrum that transmute the recycled transuranics to produce energy while also reducing the long term radiotoxicity and decay heat loading in the repository; and (3) Fast reactor fuel recycling technologies to recover and refabricate the transuranics for repeated recycling in the fast reactor system. The primary mission of the ABR Program is to demonstrate the transmutation of transuranics recovered from the LWR spent fuel, and hence the benefits of the fuel cycle closure to nuclear waste management. The transmutation, or burning of the transuranics is accomplished by fissioning and this is most effectively done in a fast spectrum. In the thermal spectrum of commercial LWRs, some transuranics capture neutrons and become even heavier transuranics rather than being fissioned. Even with repeated recycling, only about 30% can be transmuted, which is an intrinsic limitation of all thermal spectrum reactors. Only in a fast spectrum can all transuranics be effectively fissioned to eliminate their long-term radiotoxicity and decay heat. The Advanced Burner Test Reactor (ABTR) is the first step in demonstrating the transmutation technologies. It directly supports development of a prototype full-scale Advanced Burner Reactor, which would be followed by commercial deployment of ABRs. The primary objectives of the ABTR are: (1) To demonstrate reactor-based transmutation of transuranics as part of an

  17. Advanced Test Reactor National Scientific User Facility 2010 Annual Report

    Energy Technology Data Exchange (ETDEWEB)

    Mary Catherine Thelen; Todd R. Allen

    2011-05-01

    This is the 2010 ATR National Scientific User Facility Annual Report. This report provides an overview of the program for 2010, along with individual project reports from each of the university principal investigators. The report also describes the capabilities offered to university researchers here at INL and at the ATR NSUF partner facilities.

  18. ATR Performance Estimation Seed Program

    Science.gov (United States)

    2015-09-28

    NAME(S) AND ADDRESS(ES) 12. DISTRIBUTION/AVAILABILITY STATEMENT 13. SUPPLEMENTARY NOTES 14. ABSTRACT 15. SUBJECT TERMS 16. SECURITY CLASSIFICATION...distinguish between ‘imaging’ and ‘non-imaging’ ATR. The former includes traditional sidescan sonar as well as HF and LF SAS, while the latter is aimed at...and analysis tools. GTRI facilitated the collaboration by establishing Sharepoint and secure FTP sites that allowed for the exchange of documents, data

  19. Vacuum system for Advanced Test Accelerator

    Energy Technology Data Exchange (ETDEWEB)

    Denhoy, B.S.

    1981-09-03

    The Advanced Test Accelerator (ATA) is a pulsed linear electron beam accelerator designed to study charged particle beam propagation. ATA is designed to produce a 10,000 amp 50 MeV, 70 ns electron beam. The electron beam acceleration is accomplished in ferrite loaded cells. Each cell is capable of maintaining a 70 ns 250 kV voltage pulse across a 1 inch gap. The electron beam is contained in a 5 inch diameter, 300 foot long tube. Cryopumps turbomolecular pumps, and mechanical pumps are used to maintain a base pressure of 2 x 10/sup -6/ torr in the beam tube. The accelerator will be installed in an underground tunnel. Due to the radiation environment in the tunnel, the controlling and monitoring of the vacuum equipment, pressures and temperatures will be done from the control room through a computer interface. This paper describes the vacuum system design, the type of vacuum pumps specified, the reasons behind the selection of the pumps and the techniques used for computer interfacing.

  20. The Advanced Test Accelerator (ATA) experience

    Energy Technology Data Exchange (ETDEWEB)

    Chambers, F.W.

    1990-10-01

    On January 26, 1990 at 20:03:30, the Advanced Test Accelerator (ATA) was turned off with the shot counter reading 12,425,999. During the interval between 1985 and 1990 there were eight major experiments performed at ATA. Three of these experiments were for the Free Electron Laser program, and five were for the Charged Particle Beam (CPB) program. The five experiments were: Spring 1985 Propagation Experiment (April 1985), December 1985 20m Propagation Experiment (December 1985), Open Air Experiment (March--June 1987), Beam Transport Experiment (Spring 1988), and Multi Pulse Propagation Experiment (September 89--January 90). Several new technologies such as the rise time sharpener, the Beam Director, and the Fast Corrector Coil were also developed. Experiments for diagnostic development such as the transition radiation studies were also conducted. In this report the major experiments will be revisited; their highlights and shortcomings will be outlined. The current view on the understanding of lead pulse stability and CPB feasibility will be discussed.

  1. ADVANCED OXIDATION: OXALATE DECOMPOSITION TESTING WITH OZONE

    Energy Technology Data Exchange (ETDEWEB)

    Ketusky, E.; Subramanian, K.

    2012-02-29

    At the Savannah River Site (SRS), oxalic acid is currently considered the preferred agent for chemically cleaning the large underground Liquid Radioactive Waste Tanks. It is applied only in the final stages of emptying a tank when generally less than 5,000 kg of waste solids remain, and slurrying based removal methods are no-longer effective. The use of oxalic acid is preferred because of its combined dissolution and chelating properties, as well as the fact that corrosion to the carbon steel tank walls can be controlled. Although oxalic acid is the preferred agent, there are significant potential downstream impacts. Impacts include: (1) Degraded evaporator operation; (2) Resultant oxalate precipitates taking away critically needed operating volume; and (3) Eventual creation of significant volumes of additional feed to salt processing. As an alternative to dealing with the downstream impacts, oxalate decomposition using variations of ozone based Advanced Oxidation Process (AOP) were investigated. In general AOPs use ozone or peroxide and a catalyst to create hydroxyl radicals. Hydroxyl radicals have among the highest oxidation potentials, and are commonly used to decompose organics. Although oxalate is considered among the most difficult organic to decompose, the ability of hydroxyl radicals to decompose oxalate is considered to be well demonstrated. In addition, as AOPs are considered to be 'green' their use enables any net chemical additions to the waste to be minimized. In order to test the ability to decompose the oxalate and determine the decomposition rates, a test rig was designed, where 10 vol% ozone would be educted into a spent oxalic acid decomposition loop, with the loop maintained at 70 C and recirculated at 40L/min. Each of the spent oxalic acid streams would be created from three oxalic acid strikes of an F-area simulant (i.e., Purex = high Fe/Al concentration) and H-area simulant (i.e., H area modified Purex = high Al/Fe concentration

  2. Thermal modelling of Advanced LIGO test masses

    OpenAIRE

    Wang, Haoyu; Blair, Carl; Álvarez, Miguel Dovale; Brooks, Aidan; Kasprzack, Marie F.; Ramette, Joshua; Meyers, Patrick M.; Kaufer, Steffen; O'Reilly, Brian; Mow-Lowry, Conor M.; Freise, Andreas

    2016-01-01

    High-reflectivity fused silica mirrors are at the epicentre of today's advanced gravitational wave detectors. In these detectors, the mirrors interact with high power laser beams. As a result of finite absorption in the high reflectivity coatings the mirrors suffer from a variety of thermal effects that impact on the detectors' performance. We propose a model of the Advanced LIGO mirrors that introduces an empirical term to account for the radiative heat transfer between the mirror and its su...

  3. Tests Of Advanced Nickel/Hydrogen Cells

    Science.gov (United States)

    Smithrick, John J.; Hall, Stephen W.

    1994-01-01

    Individual-pressure-vessel (IPV) nickel-hydrogen technology adanced with intention of improving cycle life and performance. One advancement to use 26 percent potassium hydroxide electrolyte to improve cycle life. Another to modify state-of-art cell design to eliminate identified failure modes.

  4. Proton Testing of Advanced Stellar Compass Digital Processing Unit

    DEFF Research Database (Denmark)

    Thuesen, Gøsta; Denver, Troelz; Jørgensen, Finn E

    1999-01-01

    The Advanced Stellar Compass Digital Processing Unit was radiation tested with 300 MeV protons at Proton Irradiation Facility (PIF), Paul Scherrer Institute, Switzerland.......The Advanced Stellar Compass Digital Processing Unit was radiation tested with 300 MeV protons at Proton Irradiation Facility (PIF), Paul Scherrer Institute, Switzerland....

  5. Enhanced Low-Enriched Uranium Fuel Element for the Advanced Test Reactor

    Energy Technology Data Exchange (ETDEWEB)

    Pope, M. A. [Idaho National Lab. (INL), Idaho Falls, ID (United States); DeHart, M. D. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Morrell, S. R. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Jamison, R. K. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Nef, E. C. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Nigg, D. W. [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2015-03-01

    Under the current US Department of Energy (DOE) policy and planning scenario, the Advanced Test Reactor (ATR) and its associated critical facility (ATRC) will be reconfigured to operate on low-enriched uranium (LEU) fuel. This effort has produced a conceptual design for an Enhanced LEU Fuel (ELF) element. This fuel features monolithic U-10Mo fuel foils and aluminum cladding separated by a thin zirconium barrier. As with previous iterations of the ELF design, radial power peaking is managed using different U-10Mo foil thicknesses in different plates of the element. The lead fuel element design, ELF Mk1A, features only three fuel meat thicknesses, a reduction from the previous iterations meant to simplify manufacturing. Evaluation of the ELF Mk1A fuel design against reactor performance requirements is ongoing, as are investigations of the impact of manufacturing uncertainty on safety margins. The element design has been evaluated in what are expected to be the most demanding design basis accident scenarios and has met all initial thermal-hydraulic criteria.

  6. Status of the NGNP Fuel Experiment AGR-2 Irradiated in the Advanced Test Reactor

    Energy Technology Data Exchange (ETDEWEB)

    Blaine Grover

    2012-10-01

    The United States Department of Energy’s Next Generation Nuclear Plant (NGNP) Advanced Gas Reactor (AGR) Fuel Development and Qualification Program will be irradiating up to seven separate low enriched uranium (LEU) tri-isotopic (TRISO) particle fuel (in compact form) experiments in the Advanced Test Reactor (ATR) located at the Idaho National Laboratory (INL). These irradiations and fuel development are being accomplished to support development of the next generation reactors in the United States, and will be irradiated over the next several years to demonstrate and qualify new TRISO coated particle fuel for use in high temperature gas reactors. The goals of the irradiation experiments are to provide irradiation performance data to support fuel process development, to qualify fuel for normal operating conditions, to support development and validation of fuel performance and fission product transport models and codes, and to provide irradiated fuel and materials for post irradiation examination (PIE) and safety testing. The experiments, which will each consist of at least six separate capsules, will be irradiated in an inert sweep gas atmosphere with individual on-line temperature monitoring and control of each capsule. The sweep gas will also have on-line fission product monitoring on its effluent to track performance of the fuel in each individual capsule during irradiation. The first experiment (designated AGR-1) started irradiation in December 2006 and was completed in November 2009. The second experiment (AGR-2), which utilized the same experiment design as well as control and monitoring systems as AGR-1, started irradiation in June 2010 and is currently scheduled to be completed in April 2013. The design of this experiment and support systems will be briefly discussed, followed by the progress and status of the experiment to date.

  7. Advanced CMOS Radiation Effects Testing and Analysis

    Science.gov (United States)

    Pellish, J. A.; Marshall, P. W.; Rodbell, K. P.; Gordon, M. S.; LaBel, K. A.; Schwank, J. R.; Dodds, N. A.; Castaneda, C. M.; Berg, M. D.; Kim, H. S.; Phan, A. M.; Seidleck, C. M.

    2014-01-01

    Presentation at the annual NASA Electronic Parts and Packaging (NEPP) Program Electronic Technology Workshop (ETW). The material includes an update of progress in this NEPP task area over the past year, which includes testing, evaluation, and analysis of radiation effects data on the IBM 32 nm silicon-on-insulator (SOI) complementary metal oxide semiconductor (CMOS) process. The testing was conducted using test vehicles supplied by directly by IBM.

  8. Advanced Laboratory Setup for Testing Offshore Foundations

    DEFF Research Database (Denmark)

    Nielsen, Søren Dam; Ibsen, Lars Bo; Nielsen, Benjaminn Nordahl

    2016-01-01

    This paper describes a test setup for testing small-scale offshore foundations under realistic conditions of high pore-water pressure and high impact loads. The actuator, used for loading has enough capacity to apply sufficient force and displacement to achieve both drained and undrained failure ...

  9. Advances in DUS Test Technique for Coconut

    Institute of Scientific and Technical Information of China (English)

    Ling GAO; Li XU; Difa LlU; Rulian ZHANG

    2014-01-01

    As great progress has been made in the field of protection of new plant varieties, more attention is paid to the standardization of DUS (Distinctness, Unifor-mity, and Stability) test procedure. For further studies of tropical plants as their im-portance in agriculture and germplasm, protection of coconut becomes more signifi-cant and thus DUS test technique of coconut is needed. ln this essay, we analyzed the status quo of the DUS test guidelines by lnternational Union for the Protection of New Varieties of Plants (UPOV proj.3) and national DUS test guidelines in Chi-na, and provided some suggestions or promotions for improving the guidelines of DUS test in coconut.

  10. Advanced regenerator testing in the Raytheon dual-use cryocoolerr

    Energy Technology Data Exchange (ETDEWEB)

    Schaefer, B. R.; Bellis, L.; Ellis, M. J.; Conrad, T. J. [Raytheon Space and Airborne Systems 2000 E. El Segundo Blvd., El Segundo, CA 90245 (United States)

    2014-01-29

    Significant progress has been made on the Raytheon low cost space cryocooler called the Dual-Use Cryocooler (DUC). Most notably, the DUC has been integrated and tested with an advanced regenerator. The advanced regenerator is a drop-in replacement for stainless steel screens and has shown significant thermodynamic performance improvements. This paper will compare the performance of two different regenerators and explain the benefits of the advanced regenerator.

  11. AGR-2 Final Data Qualification Report for U.S. Capsules - ATR Cycles 147A Through 154B

    Energy Technology Data Exchange (ETDEWEB)

    Pham, Binh T. [Idaho National Lab. (INL), Idaho Falls, ID (United States). Very High-Temperature Reactor Technology Development Office; Einerson, Jeffrey J. [Idaho National Lab. (INL), Idaho Falls, ID (United States). Very High-Temperature Reactor Technology Development Office

    2014-07-01

    This report provides the data qualification status of AGR-2 fuel irradiation experimental data in four U.S. capsules from all 15 Advanced Test Reactor (ATR) Cycles 147A, 148A, 148B, 149A, 149B, 150A, 150B, 151A, 151B, 152A, 152B, 153A, 153B, 154A, and 154B, as recorded in the Nuclear Data Management and Analysis System (NDMAS). Thus, this report covers data qualification status for the entire AGR-2 irradiation and will replace four previously issued AGR-2 data qualification reports (e.g., INL/EXT-11-22798, INL/EXT-12-26184, INL/EXT-13-29701, and INL/EXT-13-30750). During AGR-2 irradiation, two cycles, 152A and 153A, occurred when the ATR core was briefly at low power, so AGR-2 irradiation data are not used for physics and thermal calculations. Also, two cycles, 150A and 153B, are Power Axial Locator Mechanism (PALM) cycles when the ATR power is higher than during normal cycles. During the first PALM cycle, 150A, the experiment was temporarily moved from the B-12 location to the ATR water canal and during the second PALM cycle, 153B, the experiment was temporarily moved from the B-12 location to the I-24 location to avoid being overheated. During the “Outage” cycle, 153A, seven flow meters were installed downstream from seven Fission Product Monitoring System (FPMS) monitors to measure flows from the monitors and these data are included in the NDMAS database.

  12. Advanced Testing Method for Ground Thermal Conductivity

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Xiaobing [ORNL; Clemenzi, Rick [Geothermal Design Center Inc.; Liu, Su [University of Tennessee (UT)

    2017-04-01

    A new method is developed that can quickly and more accurately determine the effective ground thermal conductivity (GTC) based on thermal response test (TRT) results. Ground thermal conductivity is an important parameter for sizing ground heat exchangers (GHEXs) used by geothermal heat pump systems. The conventional GTC test method usually requires a TRT for 48 hours with a very stable electric power supply throughout the entire test. In contrast, the new method reduces the required test time by 40%–60% or more, and it can determine GTC even with an unstable or intermittent power supply. Consequently, it can significantly reduce the cost of GTC testing and increase its use, which will enable optimal design of geothermal heat pump systems. Further, this new method provides more information about the thermal properties of the GHEX and the ground than previous techniques. It can verify the installation quality of GHEXs and has the potential, if developed, to characterize the heterogeneous thermal properties of the ground formation surrounding the GHEXs.

  13. Test Concept for Advanced Oxidation Techniques

    DEFF Research Database (Denmark)

    Bennedsen, Lars Rønn; Søgaard, Erik Gydesen; Mortensen, Lars

    of conducting screening laboratory and pilot tests prior to onset of full scale treatment of a contaminated site with a given technology. For this purpose, Ramboll has developed a mobile test unit in co-operation with universities and technology suppliers. The unit includes equipment for both standard and more...... of success. Based on the wide selection of different techniques, several screening matrices have been developed in order to make it easier to choose the best suited technique for a given situation. However, these matrices only provide an indication of which technology that might be effective and often...... the assessor ends up with 3 or 4 applicable techniques. In stead of selecting a full scale technique solely based on information collected during a literature research, it is best practice to supplement the remediation screening phase with laboratory and in situ pilot treatability tests. As well...

  14. Testing of Advanced Conformal Ablative TPS

    Science.gov (United States)

    Gasch, Matthew; Agrawal, Parul; Beck, Robin

    2013-01-01

    In support of the CA250 project, this paper details the results of a test campaign that was conducted at the Ames Arcjet Facility, wherein several novel low density thermal protection (TPS) materials were evaluated in an entry like environment. The motivation for these tests was to investigate whether novel conformal ablative TPS materials can perform under high heat flux and shear environment as a viable alternative to rigid ablators like PICA or Avcoat for missions like MSL and beyond. A conformable TPS over a rigid aeroshell has the potential to solve a number of challenges faced by traditional rigid TPS materials (such as tiled Phenolic Impregnated Carbon Ablator (PICA) system on MSL, and honeycomb-based Avcoat on the Orion Multi Purpose Crew Vehicle (MPCV)). The compliant (high strain to failure) nature of the conformable ablative materials will allow better integration of the TPS with the underlying aeroshell structure and enable monolithic-like configuration and larger segments to be used in fabrication.A novel SPRITE1 architecture, developed by the researchers at NASA Ames was used for arcjet testing. This small probe like configuration with 450 spherecone, enabled us to test the materials in a combination of high heat flux, pressure and shear environment. The heat flux near the nose were in the range of 500-1000 W/sq cm whereas in the flank section of the test article the magnitudes were about 50 of the nose, 250-500W/sq cm range. There were two candidate conformable materials under consideration for this test series. Both test materials are low density (0.28 g/cu cm) similar to Phenolic Impregnated Carbon Ablator (PICA) or Silicone Impregnated Refractory Ceramic Ablator (SIRCA) and are comprised of: A flexible carbon substrate (Carbon felt) infiltrated with an ablative resin system: phenolic (Conformal-PICA) or silicone (Conformal-SICA). The test demonstrated a successful performance of both the conformable ablators for heat flux conditions between 50

  15. As-Run Physics Analysis for the UCSB-1 Experiment in the Advanced Test Reactor

    Energy Technology Data Exchange (ETDEWEB)

    Nielsen, Joseph Wayne [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2015-09-01

    The University of California Santa Barbara (UCSB) -1 experiment was irradiated in the A-10 position of the ATR. The experiment was irradiated during cycles 145A, 145B, 146A, and 146B. Capsule 6A was removed from the test train following Cycle 145A and replaced with Capsule 6B. This report documents the as-run physics analysis in support of Post-Irradiation Examination (PIE) of the test. This report documents the as-run fluence and displacements per atom (DPA) for each capsule of the experiment based on as-run operating history of the ATR. Average as-run heating rates for each capsule are also presented in this report to support the thermal analysis.

  16. Advanced testing and characterization of transportation soils and bituminous sands

    CSIR Research Space (South Africa)

    Anochie-Boateng, Joseph

    2007-12-01

    Full Text Available This research study was intended to develop laboratory test procedures for advance testing and characterization of fine-grained cohesive soils and oil sand materials. The test procedures are based on typical field loading conditions and the loading...

  17. Advanced Recovery Systems Wind Tunnel Test Report

    Science.gov (United States)

    1990-08-01

    120’ leg is basically an open circuit tunnel with a closed throat test section (Figure 4.1-1). The 135,000 horse power fan drive system is enough to... AMpAcs (c.g.) = WPACSL sin(ap + ,) This methodology was applied to all the data and the induced moment, due to the offset in the PACS c.g., was removed...around wires and cables . Figure 5.3-3 depicts the nomenclature for the Cross Flow Principle. To determine CD the following equations are used: Co1 = 1.10

  18. Advances in Significance Testing for Cluster Detection

    Science.gov (United States)

    Coleman, Deidra Andrea

    Over the past two decades, much attention has been given to data driven project goals such as the Human Genome Project and the development of syndromic surveillance systems. A major component of these types of projects is analyzing the abundance of data. Detecting clusters within the data can be beneficial as it can lead to the identification of specified sequences of DNA nucleotides that are related to important biological functions or the locations of epidemics such as disease outbreaks or bioterrorism attacks. Cluster detection techniques require efficient and accurate hypothesis testing procedures. In this dissertation, we improve upon the hypothesis testing procedures for cluster detection by enhancing distributional theory and providing an alternative method for spatial cluster detection using syndromic surveillance data. In Chapter 2, we provide an efficient method to compute the exact distribution of the number and coverage of h-clumps of a collection of words. This method involves defining a Markov chain using a minimal deterministic automaton to reduce the number of states needed for computation. We allow words of the collection to contain other words of the collection making the method more general. We use our method to compute the distributions of the number and coverage of h-clumps in the Chi motif of H. influenza.. In Chapter 3, we provide an efficient algorithm to compute the exact distribution of multiple window discrete scan statistics for higher-order, multi-state Markovian sequences. This algorithm involves defining a Markov chain to efficiently keep track of probabilities needed to compute p-values of the statistic. We use our algorithm to identify cases where the available approximation does not perform well. We also use our algorithm to detect unusual clusters of made free throw shots by National Basketball Association players during the 2009-2010 regular season. In Chapter 4, we give a procedure to detect outbreaks using syndromic

  19. Light Water Reactor Sustainability Program Risk Informed Safety Margin Characterization (RISMC) Advanced Test Reactor Demonstration Case Study

    Energy Technology Data Exchange (ETDEWEB)

    Curtis Smith; David Schwieder; Cherie Phelan; Anh Bui; Paul Bayless

    2012-08-01

    Safety is central to the design, licensing, operation, and economics of Nuclear Power Plants (NPPs). Consequently, the ability to better characterize and quantify safety margin holds the key to improved decision making about LWR design, operation, and plant life extension. A systematic approach to characterization of safety margins and the subsequent margins management options represents a vital input to the licensee and regulatory analysis and decision making that will be involved. The purpose of the RISMC Pathway R&D is to support plant decisions for risk-informed margins management with the aim to improve economics, reliability, and sustain safety of current NPPs. Goals of the RISMC Pathway are twofold: (1) Develop and demonstrate a risk-assessment method coupled to safety margin quantification that can be used by NPP decision makers as part of their margin recovery strategies. (2) Create an advanced “RISMC toolkit” that enables more accurate representation of NPP safety margin. This report describes the RISMC methodology demonstration where the Advanced Test Reactor (ATR) was used as a test-bed for purposes of determining safety margins. As part of the demonstration, we describe how both the thermal-hydraulics and probabilistic safety calculations are integrated and used to quantify margin management strategies.

  20. Hawaiian Electric Advanced Inverter Test Plan - Result Summary

    Energy Technology Data Exchange (ETDEWEB)

    Hoke, Anderson; Nelson, Austin; Prabakar, Kumaraguru; Nagarajan, Adarsh

    2016-10-14

    This presentation is intended to share the results of lab testing of five PV inverters with the Hawaiian Electric Companies and other stakeholders and interested parties. The tests included baseline testing of advanced inverter grid support functions, as well as distribution circuit-level tests to examine the impact of the PV inverters on simulated distribution feeders using power hardware-in-the-loop (PHIL) techniques. hardware-in-the-loop (PHIL) techniques.

  1. Advanced Thermal Simulator Testing: Thermal Analysis and Test Results

    Science.gov (United States)

    Bragg-Sitton, Shannon M.; Dickens, Ricky; Dixon, David; Reid, Robert; Adams, Mike; Davis, Joe

    2008-01-01

    Work at the NASA Marshall Space Flight Center seeks to develop high fidelity, electrically heated thermal simulators that represent fuel elements in a nuclear reactor design to support non-nuclear testing applicable to the development of a space nuclear power or propulsion system. Comparison between the fuel pins and thermal simulators is made at the outer fuel clad surface, which corresponds to the outer sheath surface in the thermal simulator. The thermal simulators that are currently being tested correspond to a SNAP derivative reactor design that could be applied for Lunar surface power. These simulators are designed to meet the geometric and power requirements of a proposed surface power reactor design, accommodate testing of various axial power profiles, and incorporate imbedded instrumentation. This paper reports the results of thermal simulator analysis and testing in a bare element configuration, which does not incorporate active heat removal, and testing in a water-cooled calorimeter designed to mimic the heat removal that would be experienced in a reactor core.

  2. Advanced Beamline Design for Fermilab's Advanced Superconducting Test Accelerator

    Energy Technology Data Exchange (ETDEWEB)

    Prokop, Christopher [Northern Illinois Univ., DeKalb, IL (United States)

    2014-01-01

    The Advanced Superconducting Test Accelerator (ASTA) at Fermilab is a new electron accelerator currently in the commissioning stage. In addition to testing superconducting accelerating cavities for future accelerators, it is foreseen to support a variety of Advanced Accelerator R&D (AARD) experiments. Producing the required electron bunches with the expected flexibility is challenging. The goal of this dissertation is to explore via numerical simulations new accelerator beamlines that can enable the advanced manipulation of electron bunches. The work especially includes the design of a low-energy bunch compressor and a study of transverse-to-longitudinal phase space exchangers.

  3. AGR-3/4 Data Qualification Report for ATR Cycles 151A, 151B, 152A, 152B, 154A, and 154B

    Energy Technology Data Exchange (ETDEWEB)

    Binh T. Pham

    2014-02-01

    This data report provides the qualification status of Advanced Gas Reactor-3/4 (AGR-3/4) fuel irradiation experimental data from Advanced Test Reactor (ATR) Cycles 151A, 151B, 152A, 152B, 154A, and 154B, as recorded in the Nuclear Data Management and Analysis System (NDMAS). Of these cycles, ATR Cycle 152A is a low power cycle that occurred when the ATR core was briefly at low power. The irradiation data are not used for physics and thermal calculation, but the qualification status of these cycle data is still covered in this report. On the other hand, during ATR Cycles 153A (unplanned Outage cycle) and 153B (Power Axial Locator Mechanism [PALM] cycle), the AGR-3/4 was pulled out from the ATR core and stored in the canal to avoid being overheated. Therefore, qualification of the AGR-3/4 irradiation data from these 2 cycles was excluded in this report. By the end of ATR Cycle 154B, AGR-3/4 was irradiated for a total of 264.1 effective full power days. The AGR-3/4 data streams addressed in this report include thermocouple (TC) temperatures, sweep gas data (flow rates, pressure, and moisture content), and Fission Product Monitoring System (FPMS) data (release rates and release-to-birth rate ratios [R/Bs]) for each of the twelve capsules in the AGR-3/4 experiment. The final data qualification status for these data streams is determined by a Data Review Committee (DRC) composed of AGR technical leads, Sitewide Quality Assurance (QA), and NDMAS analysts. The DRC convened on February 12, 2014, reviewed the data acquisition process, and considered whether the data met the requirements for data collection as specified in QA-approved Very High Temperature Reactor (VHTR) Technology Development Office (TDO) data collection plans. The DRC also examined the results of NDMAS data testing and statistical analyses, and confirmed the qualification status of the data as given in this report.

  4. Fabrication and Comparison of Fuels for Advanced Gas Reactor Irradiation Tests

    Energy Technology Data Exchange (ETDEWEB)

    Jeffrey Phillips; Charles Barnes; John Hunn

    2010-10-01

    As part of the program to demonstrate TRISO-coated fuel for the Next Generation Nuclear Plant, a series of irradiation tests of Advanced Gas Reactor (AGR) fuel are being performed in the Advanced Test Reactor (ATR) at the Idaho National Laboratory. In the first test, called “AGR-1,” graphite compacts containing approximately 300,000 coated particles were irradiated from December 2006 until November 2009. Development of AGR-1 fuel sought to replicate the properties of German TRISO-coated particles. No particle failures were seen in the nearly 3-year irradiation to a burn up of 19%. The AGR-1 particles were coated in a two-inch diameter coater. Following fabrication of AGR-1 fuel, process improvements and changes were made in each of the fabrication processes. Changes in the kernel fabrication process included replacing the carbon black powder feed with a surface-modified carbon slurry and shortening the sintering schedule. AGR-2 TRISO particles were produced in a six-inch diameter coater using a change size about twenty-one times that of the two-inch diameter coater used to coat AGR-1 particles. Changes were also made in the compacting process, including increasing the temperature and pressure of pressing and using a different type of press. Irradiation of AGR-2 fuel began in late spring 2010. Properties of AGR-2 fuel compare favorably with AGR-1 and historic German fuel. Kernels are more homogeneous in shape, chemistry and density. TRISO-particle sphericity, layer thickness standard deviations, and defect fractions are also comparable. In a sample of 317,000 particles from deconsolidated AGR-2 compacts, 3 exposed kernels were found in a leach test. No SiC defects were found in a sample of 250,000 deconsolidated particles, and no IPyC defects in a sample of 64,000 particles. The primary difference in properties between AGR-1 and AGR-2 compacts is that AGR-2 compacts have a higher matrix density, 1.6 g/cm3 compared to about 1.3 g/cm3 for AGR-1 compacts. Based on

  5. Test Stability of Uster Advanced Fiber Information System(AFIS)

    Institute of Scientific and Technical Information of China (English)

    CAO Ji-peng; LU Qin; SUN Peng-zi; LIU Hua-pu

    2010-01-01

    To study test stability of Advanced Fiber Information System(AFIS),card sliver produced in two experiments(12 plans in each experiment)were tested by AFIS.By a statistic analysis of the test results,the number of test times that can get a reliable test reliability(hereinafter this number of test times is referred to as Reliable Test Times,RTT)of test parameters and the coefficient of variation(CV%)values of 30 test results of each experiment plan were obtained.It's concluded that some parameters,such as length,seed coat nep(SCN)size,nep size and immature fiber content(IFC),etc. are very reliable by a test of ten or more times,but other parameters,such as SCN content,trash content,and visible foreign matter(VFM)content,etc.are not reliable until they are tested over 100 times.

  6. Building virtual pentesting labs for advanced penetration testing

    CERN Document Server

    Cardwell, Kevin

    2014-01-01

    Written in an easy-to-follow approach using hands-on examples, this book helps you create virtual environments for advanced penetration testing, enabling you to build a multi-layered architecture to include firewalls, IDS/IPS, web application firewalls, and endpoint protection, which is essential in the penetration testing world. If you are a penetration tester, security consultant, security test engineer, or analyst who wants to practice and perfect penetration testing skills by building virtual pen testing labs in varying industry scenarios, this is the book for you. This book is ideal if yo

  7. Junction temperature estimation for an advanced active power cycling test

    DEFF Research Database (Denmark)

    Choi, Uimin; Blaabjerg, Frede; Jørgensen, S.

    2015-01-01

    estimation method using on-state VCE for an advanced active power cycling test is proposed. The concept of the advanced power cycling test is explained first. Afterwards the junction temperature estimation method using on-state VCE and current is presented. Further, the method to improve the accuracy......On-state collector-emitter voltage (VCE) is a good indicator to determine the wear-out condition of power device modules. Further, it is a one of the Temperature Sensitive Electrical Parameters (TSEPs) and thus can be used for junction temperature estimation. In this paper, the junction temperature...

  8. Random Vibration Testing of Advanced Wet Tantalum Capacitors

    Science.gov (United States)

    Teverovsky, Alexander

    2015-01-01

    Advanced wet tantalum capacitors allow for improved performance of power supply systems along with substantial reduction of size and weight of the systems that is especially beneficial for space electronics. Due to launch-related stresses, acceptance testing of all space systems includes random vibration test (RVT). However, many types of advanced wet tantalum capacitors cannot pass consistently RVT at conditions specified in MIL-PRF-39006, which impedes their use in space projects. This requires a closer look at the existing requirements, modes and mechanisms of failures, specifics of test conditions, and acceptance criteria. In this work, different lots of advanced wet tantalum capacitors from four manufacturers have been tested at step stress random vibration conditions while their currents were monitored before, during, and after the testing. It has been shown that the robustness of the parts and their reliability are mostly due to effective self-healing processes and limited current spiking or minor scintillations caused by RVT do not increase the risk of failures during operation. A simple model for scintillations events has been used to simulate current spiking during RVT and optimize test conditions. The significance of scintillations and possible effects of gas generation have been discussed and test acceptance criteria for limited current spiking have been suggested.

  9. Status of the Combined Third and Fourth NGNP Fuel Irradiations In the Advanced Test Reactor

    Energy Technology Data Exchange (ETDEWEB)

    S. Blaine Grover; David A. Petti; Michael E. Davenport

    2013-07-01

    The United States Department of Energy’s Next Generation Nuclear Plant (NGNP) Advanced Gas Reactor (AGR) Fuel Development and Qualification Program is irradiating up to seven low enriched uranium (LEU) tri-isotopic (TRISO) particle fuel (in compact form) experiments in the Advanced Test Reactor (ATR) located at the Idaho National Laboratory (INL). These irradiations and fuel development are being accomplished to support development of the next generation reactors in the United States. The experiments will be irradiated over the next several years to demonstrate and qualify new TRISO coated particle fuel for use in high temperature gas reactors. The goals of the experiments are to provide irradiation performance data to support fuel process development, to qualify fuel for normal operating conditions, to support development and validation of fuel performance and fission product transport models and codes, and to provide irradiated fuel and materials for post irradiation examination (PIE) and safety testing. The experiments, which will each consist of several independent capsules, will be irradiated in an inert sweep gas atmosphere with individual on-line temperature monitoring and control of each capsule. The sweep gas will also have on-line fission product monitoring on its effluent to track performance of the fuel in each individual capsule during irradiation. The first experiment (designated AGR-1) started irradiation in December 2006 and was completed in November 2009. The second experiment (AGR-2) started irradiation in June 2010 and is currently scheduled to be completed in September 2013. The third and fourth experiments have been combined into a single experiment designated (AGR-3/4), which started its irradiation in December 2011 and is currently scheduled to be completed in April 2014. Since the purpose of this combined experiment is to provide data on fission product migration and retention in the NGNP reactor, the design of this experiment is

  10. Argonne to open new facility for advanced vehicle testing

    CERN Multimedia

    2002-01-01

    Argonne National Laboratory will open it's Advanced Powertrain Research Facility on Friday, Nov. 15. The facility is North America's only public testing facility for engines, fuel cells, electric drives and energy storage. State-of-the-art performance and emissions measurement equipment is available to support model development and technology validation (1 page).

  11. Results of Laboratory Testing of Advanced Power Strips

    Energy Technology Data Exchange (ETDEWEB)

    Earle, L. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Sparn, B. [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2012-08-01

    Presented at the ACEEE Summer Study on Energy Efficiency in Buildings on August 12-17, 2012, this presentation reports on laboratory tests of 20 currently available advanced power strip products, which reduce wasteful electricity use of miscellaneous electric loads in buildings.

  12. Overview of an Advanced Hypersonic Structural Concept Test Program

    Science.gov (United States)

    Stephens, Craig A.; Hudson, Larry D.; Piazza, Anthony

    2007-01-01

    This viewgraph presentation provides an overview of hypersonics M&S advanced structural concepts development and experimental methods. The discussion on concepts development includes the background, task objectives, test plan, and current status of the C/SiC Ruddervator Subcomponent Test Article (RSTA). The discussion of experimental methods examines instrumentation needs, sensors of interest, and examples of ongoing efforts in the development of extreme environment sensors.

  13. A perspective on ATR evaluation technology

    Science.gov (United States)

    Sadjadi, Firooz; Bazakos, Mike

    1990-09-01

    A historical perspective on the evolution of performance evaluation technology for automatic target recognition (ATR) systems is presented. It is shown that the ad hoc and artistic evaluation techniques of the past are now evolving into scientific approaches. The most perspective areas of this technology include: (1) first principle coupled, multi-sensor modeling of objects, environment, atmosphere, and vegetation; (2) integration of models with the task of ATR algorithm development; (3) integration of a new generation of parallel processor that can process every pixel of an image without the need for data reduction; (4) extending the instrumentation control of ATR to include sensor selection and sensor fusion; and (5) development of signal metrics for radar, acoustic and ladar, and linking these metrics to phenomenological sources.

  14. STATUS OF TRISO FUEL IRRADIATIONS IN THE ADVANCED TEST REACTOR SUPPORTING HIGH-TEMPERATURE GAS-COOLED REACTOR DESIGNS

    Energy Technology Data Exchange (ETDEWEB)

    Davenport, Michael; Petti, D. A.; Palmer, Joe

    2016-11-01

    The United States Department of Energy’s Advanced Reactor Technologies (ART) Advanced Gas Reactor (AGR) Fuel Development and Qualification Program is irradiating up to seven low enriched uranium (LEU) tri-isotopic (TRISO) particle fuel (in compact form) experiments in the Advanced Test Reactor (ATR) located at the Idaho National Laboratory (INL). These irradiations and fuel development are being accomplished to support development of the next generation reactors in the United States. The experiments will be irradiated over the next several years to demonstrate and qualify new TRISO coated particle fuel for use in high temperature gas reactors. The goals of the experiments are to provide irradiation performance data to support fuel process development, to qualify fuel for normal operating conditions, to support development and validation of fuel performance and fission product transport models and codes, and to provide irradiated fuel and materials for post irradiation examination (PIE) and safety testing. The experiments, which will each consist of several independent capsules, will be irradiated in an inert sweep gas atmosphere with individual on-line temperature monitoring and control of each capsule. The sweep gas will also have on-line fission product monitoring on its effluent to track performance of the fuel in each individual capsule during irradiation. The first experiment (designated AGR-1) started irradiation in December 2006 and was completed in November 2009. The second experiment (AGR-2) started irradiation in June 2010 and completed in October 2013. The third and fourth experiments have been combined into a single experiment designated (AGR-3/4), which started its irradiation in December 2011 and completed in April 2014. Since the purpose of this experiment was to provide data on fission product migration and retention in the NGNP reactor, the design of this experiment was significantly different from the first two experiments, though the control

  15. AREAL test facility for advanced accelerator and radiation source concepts

    Energy Technology Data Exchange (ETDEWEB)

    Tsakanov, V.M., E-mail: tsakanov@asls.candle.am [CANDLE Synchrotron Research Institute, 0040 Yerevan (Armenia); Amatuni, G.A.; Amirkhanyan, Z.G.; Aslyan, L.V.; Avagyan, V.Sh.; Danielyan, V.A.; Davtyan, H.D.; Dekhtiarov, V.S.; Gevorgyan, K.L.; Ghazaryan, N.G.; Grigoryan, B.A.; Grigoryan, A.H.; Hakobyan, L.S. [CANDLE Synchrotron Research Institute, 0040 Yerevan (Armenia); Haroutiunian, S.G. [Yerevan State University, 0025 Yerevan (Armenia); Ivanyan, M.I.; Khachatryan, V.G.; Laziev, E.M. [CANDLE Synchrotron Research Institute, 0040 Yerevan (Armenia); Manukyan, P.S. [State Engineering University of Armenia, 0009 Yerevan (Armenia); Margaryan, I.N.; Markosyan, T.M. [CANDLE Synchrotron Research Institute, 0040 Yerevan (Armenia); and others

    2016-09-01

    Advanced Research Electron Accelerator Laboratory (AREAL) is a 50 MeV electron linear accelerator project with a laser driven RF gun being constructed at the CANDLE Synchrotron Research Institute. In addition to applications in life and materials sciences, the project aims as a test facility for advanced accelerator and radiation source concepts. In this paper, the AREAL RF photoinjector performance, the facility design considerations and its highlights in the fields of free electron laser, the study of new high frequency accelerating structures, the beam microbunching and wakefield acceleration concepts are presented.

  16. Future opportunities for advancing glucose test device electronics.

    Science.gov (United States)

    Young, Brian R; Young, Teresa L; Joyce, Margaret K; Kennedy, Spencer I; Atashbar, Massood Z

    2011-09-01

    Advancements in the field of printed electronics can be applied to the field of diabetes testing. A brief history and some new developments in printed electronics components applicable to personal test devices, including circuitry, batteries, transmission devices, displays, and sensors, are presented. Low-cost, thin, and lightweight materials containing printed circuits with energy storage or harvest capability and reactive/display centers, made using new printing/imaging technologies, are ideal for incorporation into personal-use medical devices such as glucose test meters. Semicontinuous rotogravure printing, which utilizes flexible substrates and polymeric, metallic, and/or nano "ink" composite materials to effect rapidly produced, lower-cost printed electronics, is showing promise. Continuing research advancing substrate, "ink," and continuous processing development presents the opportunity for research collaboration with medical device designers.

  17. Characterization of mudrocks: a practical application of advanced laboratory testing

    Institute of Scientific and Technical Information of China (English)

    Richard J.JARDINE

    2011-01-01

    An integrated approach to geomaterial characterization is advocated that combines geology, in-situ testing, fabric studies, routine index experiments and advanced laboratory testing. It is shown that advanced laboratory testing can explore features such as kinematic yielding and anisotropy in stiffness or shear strength that would otherwise be impossible to quantify. A detailed study performed in London clay at the new Heathrow Terminal 5 site is used to illustrate the arguments made. It is shown that the London clay has strong anisotropy in stiffness, is highly non-linear over the strain range of engineering interest, has markedly anisotropic shear strength characteristics and exhibits a pronounced degree of brittleness. These features can impact significantly on the practical design and analysis of civil engineering works including shallow and deep foundations, tunnels and excavations, and the stability of slopes.

  18. Attenuated total reflection Fourier-transform infrared (ATR-FTIR) imaging of tissues and live cells.

    Science.gov (United States)

    Andrew Chan, K L; Kazarian, Sergei G

    2016-04-07

    FTIR spectroscopic imaging is a label-free, non-destructive and chemically specific technique that can be utilised to study a wide range of biomedical applications such as imaging of biopsy tissues, fixed cells and live cells, including cancer cells. In particular, the use of FTIR imaging in attenuated total reflection (ATR) mode has attracted much attention because of the small, but well controlled, depth of penetration and corresponding path length of infrared light into the sample. This has enabled the study of samples containing large amounts of water, as well as achieving an increased spatial resolution provided by the high refractive index of the micro-ATR element. This review is focused on discussing the recent developments in FTIR spectroscopic imaging, particularly in ATR sampling mode, and its applications in the biomedical science field as well as discussing the future opportunities possible as the imaging technology continues to advance.

  19. A Methodology for Loading the Advanced Test Reactor Driver Core for Experiment Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Cowherd, Wilson M.; Nielsen, Joseph W.; Choe, Dong O.

    2016-11-01

    In support of experiments in the ATR, a new methodology was devised for loading the ATR Driver Core. This methodology will replace the existing methodology used by the INL Neutronic Analysis group to analyze experiments. Studied in this paper was the as-run analysis for ATR Cycle 152B, specifically comparing measured lobe powers and eigenvalue calculations.

  20. Tests of Full-Scale Helicopter Rotors at High Advancing Tip Mach Numbers and Advance Ratios

    Science.gov (United States)

    Biggers, James C.; McCloud, John L., III; Stroub, Robert H.

    2015-01-01

    As a continuation of the studies of reference 1, three full-scale helicopter rotors have been tested in the Ames Research Center 40- by SO-foot wind tunnel. All three of them were two-bladed, teetering rotors. One of the rotors incorporated the NACA 0012 airfoil section over the entire length of the blade. This rotor was tested at advance ratios up to 1.05. Both of the other rotors were tapered in thickness and incorporated leading-edge camber over the outer 20 percent of the blade radius. The larger of these rotors was tested at advancing tip Mach numbers up to 1.02. Data were obtained for a wide range of lift and propulsive force, and are presented without discussion.

  1. Advanced Grid Support Functionality Testing for Florida Power and Light

    Energy Technology Data Exchange (ETDEWEB)

    Nelson, Austin [National Renewable Energy Lab. (NREL), Golden, CO (United States); Martin, Gregory [National Renewable Energy Lab. (NREL), Golden, CO (United States); Hurtt, James [Florida Power and Light, Juno Beach, FL (United States)

    2017-03-21

    This report describes the results of laboratory testing of advanced photovoltaic (PV) inverter testing undertaken by the National Renewable Energy Laboratory (NREL) on behalf of the Florida Power and Light Company (FPL). FPL recently commissioned a 1.1 MW-AC PV installation on a solar carport at the Daytona International Speedway in Daytona Beach, Florida. In addition to providing a source of clean energy production, the site serves as a live test bed with 36 different PV inverters from eight different manufacturers. Each inverter type has varied support for advanced grid support functions (GSFs) that are becoming increasingly commonplace, and are being required through revised interconnection standards such as UL1741, IEEE1547, and California (CA) Rule 21. FPL is interested in evaluating the trade-offs between different GSFs, their compliance to emerging standards, and their effects on efficiency and reliability. NREL has provided a controlled laboratory environment to undertake such a study. This work covered nine different classes of tests to compare inverter capabilities and performance for four different inverters that were selected by FPL. The test inverters were all three-phase models rated between 24-36 kW, and containing multiple PV input power point trackers. Advanced grid support functions were tested for functional behavior, and included fixed power factor operation, voltage-ride through, frequency ride-through, volt-var control, and frequency-Watt control. Response to abnormal grid conditions with GSFs enabled was studied through anti-islanding, fault, and load rejection overvoltage tests. Finally, efficiency was evaluated across a range of operating conditions that included power factor, output power, and input voltage variations. Test procedures were derived from requirements of a draft revision of UL741, CA Rule 21, and/or previous studies at NREL. This reports summarizes the results of each test case, providing a comparative performance analysis

  2. UTILITY ADVANCED TURBINE SYSTEMS (ATS) TECHNOLOGY READINESS TESTING

    Energy Technology Data Exchange (ETDEWEB)

    Unknown

    1998-10-01

    The overall objective of the Advanced Turbine System (ATS) Phase 3 Cooperative Agreement between Ge and the US Department of Energy (DOE) is the development of the GE 7H and 9H combined cycle power systems. The major effort will be expended on detail design. Validation of critical components and technologies will be performed, including: hot gas path component testing, sub-scale compressor testing, steam purity test trials, and rotational heat transfer confirmation testing. Processes will be developed to support the manufacture of the first system, which was to have been sited and operated in Phase 4 but will now be sited and operated commercially be GE. This change has resulted from DOE's request to GE for deletion of Phase 4 in favor of a restructured Phase 3 (as Phase 3R) to include full speed, no load (FSNL) testing of the 7H gas turbine. Technology enhancements that are not required for the first machine design but will be critical for future ATS advances in performance, reliability, and costs will be initiated. Long-term tests of materials to confirm design life predictions will continue. A schematic of the GE H machine is shown. This report summarizes work accomplished from 4Q97 through 3Q98.

  3. Utility Advanced Turbine Systems (ATS) Technology Readiness Testing

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-10-29

    The overall objective of the Advanced Turbine System (ATS) Phase 3 Cooperative Agreement between GE and the U.S. Department of Energy (DOE) is the development of the GE 7H and 9H combined cycle power systems. The major effort will be expended on detail design. Validation of critical components and technologies will be performed, including: hot gas path component testing, sub-scale compressor testing, steam purity test trials, and rotational heat transfer confirmation testing. Processes will be developed to support the manufacture of the first system, which was to have been sited and operated in Phase 4 but will now be sited and operated commercially by GE. This change has resulted from DOE's request to GE for deletion of Phase 4 in favor of a restructured Phase 3 (as Phase 3R) to include full speed, no load (FSNL) testing of the 7H gas turbine. Technology enhancements that are not required for the first machine design but will be critical for future ATS advances in performance, reliability, and costs will be initiated. Long-term tests of materials to confirm design life predictions will continue. A schematic of the GE H machine is shown in Figure 1-1. This report summarizes work accomplished in 2Q98. The most significant accomplishments are listed in the report.

  4. Utility advanced turbine systems (ATS) technology readiness testing

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-09-15

    The overall objective of the Advanced Turbine System (ATS) Phase 3 Cooperative Agreement between GE and the US Department of Energy (DOE) is the development of a highly efficient, environmentally superior, and cost-competitive utility ATS for base-load utility-scale power generation, the GE 7H (60 Hz) combined cycle power system, and related 9H (50 Hz) common technology. The major effort will be expended on detail design. Validation of critical components and technologies will be performed, including: hot gas path component testing, sub-scale compressor testing, steam purity test trials, and rotational heat transfer confirmation testing. Processes will be developed to support the manufacture of the first system, which was to have been sited and operated in Phase 4 but will now be sited and operated commercially by GE. This change has resulted from DOE's request to GE for deletion of Phase 4 in favor of a restructured Phase 3 (as Phase 3R) to include full speed, no load (FSNL) testing of the 7H gas turbine. Technology enhancements that are not required for the first machine design but will be critical for future ATS advances in performance, reliability, and costs will be initiated. Long-term tests of materials to confirm design life predictions will continue. A schematic of the GE H machine is shown.

  5. Utility Advanced Turbine Systems (ATS) technology readiness testing

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-05-01

    The overall objective of the Advanced Turbine System (ATS) Phase 3 Cooperative Agreement between GE and the US Department of Energy (DOE) is the development of the GE 7H and 9H combined cycle power systems. The major effort will be expended on detail design. Validation of critical components and technologies will be performed, including: hot gas path component testing, sub-scale compressor testing, steam purity test trials, and rotational heat transfer confirmation testing. Processes will be developed to support the manufacture of the first system, which was to have been sited and operated in Phase 4 but will now be sited and operated commercially by GE. This change has resulted horn DOE's request to GE for deletion of Phase 4 in favor of a restructured Phase 3 (as Phase 3R) to include fill speed, no load (FSNL) testing of the 7H gas turbine. Technology enhancements that are not required for the first machine design but will be critical for future ATS advances in performance, reliability, and costs will be initiated. Long-term tests of materials to confirm design life predictions will continue. A schematic of the GE H machine is shown.

  6. Structural Dynamics Testing of Advanced Stirling Convertor Components

    Science.gov (United States)

    Oriti, Salvatore M.; Williams, Zachary Douglas

    2013-01-01

    NASA Glenn Research Center has been supporting the development of Stirling energy conversion for use in space. Lockheed Martin has been contracted by the Department of Energy to design and fabricate flight-unit Advanced Stirling Radioisotope Generators, which utilize Sunpower, Inc., free-piston Advanced Stirling Convertors. The engineering unit generator has demonstrated conversion efficiency in excess of 20 percent, offering a significant improvement over existing radioisotope-fueled power systems. NASA Glenn has been supporting the development of this generator by developing the convertors through a technology development contract with Sunpower, and conducting research and experiments in a multitude of areas, such as high-temperature material properties, organics testing, and convertor-level extended operation. Since the generator must undergo launch, several launch simulation tests have also been performed at the convertor level. The standard test sequence for launch vibration exposure has consisted of workmanship and flight acceptance levels. Together, these exposures simulate what a flight convertor will experience. Recently, two supplementary tests were added to the launch vibration simulation activity. First was a vibration durability test of the convertor, intended to quantify the effect of vibration levels up to qualification level in both the lateral and axial directions. Second was qualification-level vibration of several heater heads with small oxide inclusions in the material. The goal of this test was to ascertain the effect of the inclusions on launch survivability to determine if the heater heads were suitable for flight.

  7. Training Convolutional Neural Networks for Translational Invariance on SAR ATR

    DEFF Research Database (Denmark)

    Malmgren-Hansen, David; Engholm, Rasmus; Østergaard Pedersen, Morten

    2016-01-01

    In this paper we present a comparison of the robustness of Convolutional Neural Networks (CNN) to other classifiers in the presence of uncertainty of the objects localization in SAR image. We present a framework for simulating simple SAR images, translating the object of interest systematically...... and testing the classification performance. Our results show that where other classification methods are very sensitive to even small translations, CNN is quite robust to translational variance, making it much more useful in relation to Automatic Target Recognition (ATR) in a real life context....

  8. A Feasibility Study to Determine Cooling Time and Burnup of ATR Fuel Using a Nondestructive Technique and Three Types of Gamma-ray Detectors

    Energy Technology Data Exchange (ETDEWEB)

    Jorge Navarro; Rahmat Aryaeinejad,; David W. Nigg

    2011-05-01

    A Feasibility Study to Determine Cooling Time and Burnup of ATR Fuel Using a Nondestructive Technique1 Rahmat Aryaeinejad, Jorge Navarro, and David W Nigg Idaho National Laboratory Abstract Effective and efficient Advanced Test Reactor (ATR) fuel management require state of the art core modeling tools. These new tools will need isotopic and burnup validation data before they are put into production. To create isotopic, burn up validation libraries and to determine the setup for permanent fuel scanner system a feasibility study was perform. The study consisted in measuring short and long cooling time fuel elements at the ATR canal. Three gamma spectroscopy detectors (HPGe, LaBr3, and HPXe) and two system configurations (above and under water) were used in the feasibility study. The first stage of the study was to investigate which detector and system configuration would be better suited for different scenarios. The second stage of the feasibility study was to create burnup and cooling time calibrations using experimental isotopic data collected and ORIGEN 2.2 burnup data. The results of the study establish that a better spectra resolution is achieve with an above the water configuration and that three detectors can be used in the permanent fuel scanner system for different situations. In addition it was conclude that a number of isotopic ratios and absolute measurements could be used to predict ATR fuel burnup and cooling times. 1This work was supported by the U.S. Depart¬ment of Energy (DOE) under Battelle Energy Alliance, LLC Contract No. DE-AC07-05ID14517.

  9. The distribution of atrazine (ATR) and ATR metabolites in the Wistar rat following gestational/lactational exposures

    Science.gov (United States)

    Gestational/lactational exposure to ATR is reported to alter reproductive/developmental function, yet our understanding of the transfer of ATR and/or its metabolites from the dam to the fetus/offspring is limited. Previously we examined the lactational transfer of CI4-ATR, but sp...

  10. The distribution of atrazine (ATR) and ATR metabolites in the Wistar rat following gestational/lactational exposures

    Science.gov (United States)

    Gestational/lactational exposure to ATR is reported to alter reproductive/developmental function, yet our understanding of the transfer of ATR and/or its metabolites from the dam to the fetus/offspring is limited. Previously we examined the lactational transfer of CI4-ATR, but sp...

  11. Advanced Test Accelerator (ATA) pulse power technology development

    Energy Technology Data Exchange (ETDEWEB)

    Reginato, L.L.; Branum, D.; Cook, E.

    1981-03-09

    The Advanced Test Accelerator (ATA) is a pulsed linear induction accelerator with the following design parameters: 50 MeV, 10 kA, 70 ns, and 1 kHz in a ten-pulse burst. Acceleration is accomplished by means of 190 ferrite-loaded cells, each capable of maintaining a 250 kV voltage pulse for 70 ns across a 1-inch gap. The unique characteristic of this machine is its 1 kHz burst mode capability at very high currents. This paper dscribes the pulse power development program which used the Experimental Test Accelerator (ETA) technology as a starting base. Considerable changes have been made both electrically and mechanically in the pulse power components with special consideration being given to the design to achieve higher reliability. A prototype module which incorporates all the pulse power components has been built and tested for millions of shots. Prototype components and test results are described.

  12. PRELIMINARY RESULTS OF THE AGC-4 IRRADIATION IN THE ADVANCED TEST REACTOR AND DESIGN OF AGC-5 (HTR16-18469)

    Energy Technology Data Exchange (ETDEWEB)

    Davenport, Michael; Petti, D. A.

    2016-11-01

    The United States Department of Energy’s Advanced Reactor Technologies (ART) Program will irradiate up to six nuclear graphite creep experiments in the Advanced Test Reactor (ATR) located at the Idaho National Laboratory (INL). The graphite experiments are being irradiated over an approximate eight year period to support development of a graphite irradiation performance data base on the new nuclear grade graphites now available for use in high temperature gas reactors. The goals of the irradiation experiments are to obtain irradiation performance data, including irradiation creep, at different temperatures and loading conditions to support design of the Very High Temperature Gas Reactor (VHTR), as well as other future gas reactors. The experiments each consist of a single capsule that contain six stacks of graphite specimens, with half of the graphite specimens in each stack under a compressive load, while the other half of the specimens are not be subjected to a compressive load during irradiation. The six stacks have differing compressive loads applied to the top half of diametrically opposite pairs of specimen stacks. A seventh specimen stack in the center of the capsule does not have a compressive load. The specimens are being irradiated in an inert sweep gas atmosphere with on-line temperature and compressive load monitoring and control. There are also samples taken of the sweep gas effluent to measure any oxidation or off-gassing of the specimens that may occur during initial start-up of the experiment. The first experiment, AGC-1, started its irradiation in September 2009, and the irradiation was completed in January 2011. The second experiment, AGC-2, started its irradiation in April 2011 and completed its irradiation in May 2012. The third experiment, AGC-3, started its irradiation in late November 2012 and completed in the April of 2014. AGC-4 is currently being irradiated in the ATR. This paper will briefly discuss the preliminary irradiation results

  13. Listening strategy use, test anxiety and test performance of intermediate and advanced Iranian EFL learners

    Directory of Open Access Journals (Sweden)

    Raoof Hamzavi

    2014-08-01

    Full Text Available Learning a foreign language has been related with some kind of strategic knowledge on the one hand, and some level of (test-taking apprehension or tension on the other hand, although a small amount of anxiety is normally expected as a natural warning symptom. The current study aimed at investigating the relationship between listening strategy use, test anxiety, and listening test performance of Iranian intermediate and advanced EFL learners. To this end, eighty (40 intermediate and 40 advanced Iranian EFL learners took part in the study by completing Lee’s (1997 Listening Comprehension Strategy Questionnaire, Sarason’s (1975 Test Anxiety Scale (TAS, and two monologues of Listening test performance selected from Listening part of TOEFL. The results of Pearson product moment correlation analyses revealed a significant negative correlation between test anxiety and listening test performance, but a significant positive association between listening strategy use and listening test performance. Furthermore, the results of multiple regression analyses indicated listening strategy use was a stronger predictor of listening test performance. Additionally, the results of independent samples t-test showed a significant difference between Iranian intermediate and advanced EFL learners regarding both their listening strategy use and level of test anxiety.

  14. Wind Tunnel Tests on Aerodynamic Characteristics of Advanced Solid Rocket

    Science.gov (United States)

    Kitamura, Keiichi; Fujimoto, Keiichiro; Nonaka, Satoshi; Irikado, Tomoko; Fukuzoe, Moriyasu; Shima, Eiji

    The Advanced Solid Rocket is being developed by JAXA (Japan Aerospace Exploration Agency). Since its configuration has been changed very recently, its aerodynamic characteristics are of great interest of the JAXA Advanced Solid Rocket Team. In this study, we carried out wind tunnel tests on the aerodynamic characteristics of the present configuration for Mach 1.5. Six test cases were conducted with different body configurations, attack angles, and roll angles. A six component balance, oilflow visualization, Schlieren images were used throughout the experiments. It was found that, at zero angle-of-attack, the flow around the body were perturbed and its drag (axial force) characteristics were significantly influenced by protruding body components such as flanges, cable ducts, and attitude control units of SMSJ (Solid Motor Side Jet), while the nozzle had a minor role. With angle-of-attack of five degree, normal force of CNα = 3.50±0.03 was measured along with complex flow features observed in the full-component model; whereas no crossflow separations were induced around the no-protuberance model with CNα = 2.58±0.10. These values were almost constant with respect to the angle-of-attack in both of the cases. Furthermore, presence of roll angle made the flow more complicated, involving interactions of separation vortices. These data provide us with fundamental and important aerodynamic insights of the Advanced Solid Rocket, and they will be utilized as reference data for the corresponding numerical analysis.

  15. Advances in Testing Techniques for Digital Microfluidic Biochips

    Science.gov (United States)

    Shukla, Vineeta; Hussin, Fawnizu Azmadi; Hamid, Nor Hisham; Zain Ali, Noohul Basheer

    2017-01-01

    With the advancement of digital microfluidics technology, applications such as on-chip DNA analysis, point of care diagnosis and automated drug discovery are common nowadays. The use of Digital Microfluidics Biochips (DMFBs) in disease assessment and recognition of target molecules had become popular during the past few years. The reliability of these DMFBs is crucial when they are used in various medical applications. Errors found in these biochips are mainly due to the defects developed during droplet manipulation, chip degradation and inaccuracies in the bio-assay experiments. The recently proposed Micro-electrode-dot Array (MEDA)-based DMFBs involve both fluidic and electronic domains in the micro-electrode cell. Thus, the testing techniques for these biochips should be revised in order to ensure proper functionality. This paper describes recent advances in the testing technologies for digital microfluidics biochips, which would serve as a useful platform for developing revised/new testing techniques for MEDA-based biochips. Therefore, the relevancy of these techniques with respect to testing of MEDA-based biochips is analyzed in order to exploit the full potential of these biochips. PMID:28749411

  16. Advances in Testing Techniques for Digital Microfluidic Biochips

    Directory of Open Access Journals (Sweden)

    Vineeta Shukla

    2017-07-01

    Full Text Available With the advancement of digital microfluidics technology, applications such as on-chip DNA analysis, point of care diagnosis and automated drug discovery are common nowadays. The use of Digital Microfluidics Biochips (DMFBs in disease assessment and recognition of target molecules had become popular during the past few years. The reliability of these DMFBs is crucial when they are used in various medical applications. Errors found in these biochips are mainly due to the defects developed during droplet manipulation, chip degradation and inaccuracies in the bio-assay experiments. The recently proposed Micro-electrode-dot Array (MEDA-based DMFBs involve both fluidic and electronic domains in the micro-electrode cell. Thus, the testing techniques for these biochips should be revised in order to ensure proper functionality. This paper describes recent advances in the testing technologies for digital microfluidics biochips, which would serve as a useful platform for developing revised/new testing techniques for MEDA-based biochips. Therefore, the relevancy of these techniques with respect to testing of MEDA-based biochips is analyzed in order to exploit the full potential of these biochips.

  17. UTILITY ADVANCED TURBINE SYSTEMS (ATS) TECHNOLOGY READINESS TESTING

    Energy Technology Data Exchange (ETDEWEB)

    Unknown

    1999-04-01

    The overall objective of the Advanced Turbine System (ATS) Phase 3 Cooperative Agreement between GE and the U.S. Department of Energy (DOE) is the development of the GE 7H and 9H combined cycle power systems. The major effort will be expended on detail design. Validation of critical components and technologies will be performed, including: hot gas path component testing, sub-scale compressor testing, steam purity test trials, and rotational heat transfer conflation testing. Processes will be developed to support the manufacture of the first system, which was to have been sited and operated in Phase 4 but will now be sited and operated commercially by GE. This change has resulted from DOE's request to GE for deletion of Phase 4 in favor of a restructured Phase 3 (as Phase 3R) to include full speed, no load (FSNL) testing of the 7H gas turbine. Technology enhancements that are not required for the first machine design but will be critical for future ATS advances in performance, reliability, and costs will be initiated. Long-term tests of materials to confirm design life predictions will continue. The objective of this task is to design 7H and 9H compressor rotor and stator structures with the goal of achieving high efficiency at lower cost and greater durability by applying proven GE Power Systems (GEPS) heavy-duty use design practices. The designs will be based on the GE Aircraft Engines (GEAE) CF6-80C2 compressor. Transient and steady-state thermo-mechanical stress analyses will be run to ensure compliance with GEPS life standards. Drawings will be prepared for forgings, castings, machining, and instrumentation for full speed, no load (FSNL) tests of the first unit on both 9H and 7H applications.

  18. Gas Test Loop Booster Fuel Hydraulic Testing

    Energy Technology Data Exchange (ETDEWEB)

    Gas Test Loop Hydraulic Testing Staff

    2006-09-01

    The Gas Test Loop (GTL) project is for the design of an adaptation to the Advanced Test Reactor (ATR) to create a fast-flux test space where fuels and materials for advanced reactor concepts can undergo irradiation testing. Incident to that design, it was found necessary to make use of special booster fuel to enhance the neutron flux in the reactor lobe in which the Gas Test Loop will be installed. Because the booster fuel is of a different composition and configuration from standard ATR fuel, it is necessary to qualify the booster fuel for use in the ATR. Part of that qualification is the determination that required thermal hydraulic criteria will be met under routine operation and under selected accident scenarios. The Hydraulic Testing task in the GTL project facilitates that determination by measuring flow coefficients (pressure drops) over various regions of the booster fuel over a range of primary coolant flow rates. A high-fidelity model of the NW lobe of the ATR with associated flow baffle, in-pile-tube, and below-core flow channels was designed, constructed and located in the Idaho State University Thermal Fluids Laboratory. A circulation loop was designed and constructed by the university to provide reactor-relevant water flow rates to the test system. Models of the four booster fuel elements required for GTL operation were fabricated from aluminum (no uranium or means of heating) and placed in the flow channel. One of these was instrumented with Pitot tubes to measure flow velocities in the channels between the three booster fuel plates and between the innermost and outermost plates and the side walls of the flow annulus. Flow coefficients in the range of 4 to 6.5 were determined from the measurements made for the upper and middle parts of the booster fuel elements. The flow coefficient for the lower end of the booster fuel and the sub-core flow channel was lower at 2.3.

  19. The Advanced Photon Source Injector Test Stand Control System

    CERN Document Server

    MacLean, J F

    2001-01-01

    The Advanced Photon Source (APS) primary and backup injectors consist of two thermionic-cathode rf guns. These guns are being upgraded to provide improved performance, to improve ease of maintenance, and to reduce downtime required for repair or replacement of a failed injector. As part of the process, an injector test stand is being prepared. This stand is effectively independent of the APS linac and will allow for complete characterization and validation of an injector prior to its installation into the APS linac. A modular control system for the test stand has been developed using standard APS control solutions with EPICS to deliver a flexible and comprehensive control system. The modularity of the system will allow both the future expansion of test stand functionality and the evaluation of new control techniques and solutions.

  20. Advanced Hot Section Materials and Coatings Test Rig

    Energy Technology Data Exchange (ETDEWEB)

    Dan Davis

    2006-09-30

    Phase I of the Hyperbaric Advanced Hot Section Materials & Coating Test Rig Program has been successfully completed. Florida Turbine Technologies has designed and planned the implementation of a laboratory rig capable of simulating the hot gas path conditions of coal gas fired industrial gas turbine engines. Potential uses of this rig include investigations into environmental attack of turbine materials and coatings exposed to syngas, erosion, and thermal-mechanical fatigue. The principle activities during Phase 1 of this project included providing several conceptual designs for the test section, evaluating various syngas-fueled rig combustor concepts, comparing the various test section concepts and then selecting a configuration for detail design. Conceptual definition and requirements of auxiliary systems and facilities were also prepared. Implementation planning also progressed, with schedules prepared and future project milestones defined. The results of these tasks continue to show rig feasibility, both technically and economically.

  1. Cooperative Software Testing and Analysis:Advances and Challenges

    Institute of Scientific and Technical Information of China (English)

    谢涛; 张路; 肖旭生; 熊英飞; 郝丹

    2014-01-01

    In recent years, to maximize the value of software testing and analysis, we have proposed the methodology of cooperative software testing and analysis (in short as cooperative testing and analysis) to enable testing and analysis tools to cooperate with their users (in the form of tool-human cooperation), and enable one tool to cooperate with another tool (in the form of tool-tool cooperation). Such cooperations are motivated by the observation that a tool is typically not powerful enough to address complications in testing or analysis of complex real-world software, and the tool user or another tool may be able to help out some problems faced by the tool. To enable tool-human or tool-tool cooperation, effective mechanisms need to be developed 1) for a tool to communicate problems faced by the tool to the tool user or another tool, and 2) for the tool user or another tool to assist the tool to address the problems. Such methodology of cooperative testing and analysis forms a new research frontier on synergistic cooperations between humans and tools along with cooperations between tools and tools. This article presents recent example advances and challenges on cooperative testing and analysis.

  2. Selected Can-Do Statements and Learning Materials for ATR CALL BRIX: Helping University Students in Japan Improve Their TOEIC Scores

    Science.gov (United States)

    Ishikawa, Yasushige; Kondo, Mutsumi; Akahane-Yamada, Reiko; Smith, Craig; Hatakeda, Hiroshi; Wada, Norihisa

    2012-01-01

    This paper reports on the use of can-do statements (CDS) for the development of learning materials to prepare Japanese university students for the Test of English for International Communication (TOEIC). These learning materials have been made available on ATR CALL BRIX (http://www.atr-lt.jp/products/brix/index.html), a wwwbased courseware with a…

  3. UTILITY ADVANCED TURBINE SYSTEMS (ATS) TECHNOLOGY READINESS TESTING

    Energy Technology Data Exchange (ETDEWEB)

    Unknown

    1999-10-01

    The overall objective of the Advanced Turbine System (ATS) Phase 3 Cooperative Agreement between GE and the U.S. Department of Energy (DOE) is the development of a highly efficient, environmentally superior, and cost-competitive utility ATS for base-load utility-scale power generation, the GE 7H (60 Hz) combined cycle power system, and related 9H (50 Hz) common technology. The major effort will be expended on detail design. Validation of critical components and technologies will be performed, including: hot gas path component testing, sub-scale compressor testing, steam purity test trials, and rotational heat transfer confirmation testing. Processes will be developed to support the manufacture of the first system, which was to have been sited and operated in Phase 4 but will now be sited and operated commercially by GE. This change has resulted from DOE's request to GE for deletion of Phase 4 in favor of a restructured Phase 3 (as Phase 3R) to include full speed, no load (FSNL) testing of the 7H gas turbine. Technology enhancements that are not required for the first machine design but will be critical for future ATS advances in performance, reliability, and costs will be initiated. Long-term tests of materials to confirm design life predictions will continue. A schematic of the GE H machine is shown in Figure 1-1. Information specifically related to 9H production is presented for continuity in H program reporting, but lies outside the ATS program. This report summarizes work accomplished from 4Q98 through 3Q99. The most significant accomplishments are listed.

  4. The Advanced Superconducting Test Accelerator at Fermilab: Science Program

    Energy Technology Data Exchange (ETDEWEB)

    Piot, Philippe [Fermilab; Harms, Elvin [Fermilab; Henderson, Stuart [Fermilab; Leibfritz, Jerry [Fermilab; Nagaitsev, Sergei [Fermilab; Shiltsev, Vladimir [Fermilab; Valishev, Alexander [Fermilab

    2014-07-01

    The Advanced Superconducting Test Accelerator (ASTA) currently in commissioning phase at Fermilab is foreseen to support a broad range of beam-based experiments to study fundamental limitations to beam intensity and to develop novel approaches to particle-beam generation, acceleration and manipulation. ASTA incorporates a superconducting radiofrequency (SCRF) linac coupled to a flexible high-brightness photoinjector. The facility also includes a small-circumference storage ring capable of storing electrons or protons. This report summarizes the facility capabilities, and provide an overview of the accelerator-science researches to be enabled.

  5. Testing aspects of advanced coherent electron cooling technique

    Energy Technology Data Exchange (ETDEWEB)

    Litvinenko, V.; Jing, Y.; Pinayev, I.; Wang, G.; Samulyak, R.; Ratner, D.

    2015-05-03

    An advanced version of the Coherent-electron Cooling (CeC) based on the micro-bunching instability was proposed. This approach promises significant increase in the bandwidth of the CeC system and, therefore, significant shortening of cooling time in high-energy hadron colliders. In this paper we present our plans of simulating and testing the key aspects of this proposed technique using the set-up of the coherent-electron-cooling proof-of-principle experiment at BNL.

  6. Test Protocols for Advanced Inverter Interoperability Functions - Appendices

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, Jay Dean [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Gonzalez, Sigifredo [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Ralph, Mark E. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Ellis, Abraham [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Broderick, Robert Joseph [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2013-11-01

    Distributed energy resources (DER) such as photovoltaic (PV) systems, when deployed in a large scale, are capable of influencing significantly the operation of power systems. Looking to the future, stakeholders are working on standards to make it possible to manage the potentially complex interactions between DER and the power system. In 2009, the Electric Power Research Institute (EPRI), Sandia National Laboratories (SNL) with the U.S. Department of Energy (DOE), and the Solar Electric Power Association (SEPA) initiated a large industry collaborative to identify and standardize definitions for a set of DER grid support functions. While the initial effort concentrated on grid-tied PV inverters and energy storage systems, the concepts have applicability to all DER. A partial product of this on-going effort is a reference definitions document (IEC TR 61850-90-7, Object models for power converters in distributed energy resources (DER) systems) that has become a basis for expansion of related International Electrotechnical Commission (IEC) standards, and is supported by US National Institute of Standards and Technology (NIST) Smart Grid Interoperability Panel (SGIP). Some industry-led organizations advancing communications protocols have also embraced this work. As standards continue to evolve, it is necessary to develop test protocols to independently verify that the inverters are properly executing the advanced functions. Interoperability is assured by establishing common definitions for the functions and a method to test compliance with operational requirements. This document describes test protocols developed by SNL to evaluate the electrical performance and operational capabilities of PV inverters and energy storage, as described in IEC TR 61850-90-7. While many of these functions are not now required by existing grid codes or may not be widely available commercially, the industry is rapidly moving in that direction. Interoperability issues are already apparent as

  7. Test Protocols for Advanced Inverter Interoperability Functions – Main Document

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, Jay Dean [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Gonzalez, Sigifredo [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Ralph, Mark E. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Ellis, Abraham [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Broderick, Robert Joseph [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2013-11-01

    Distributed energy resources (DER) such as photovoltaic (PV) systems, when deployed in a large scale, are capable of influencing significantly the operation of power systems. Looking to the future, stakeholders are working on standards to make it possible to manage the potentially complex interactions between DER and the power system. In 2009, the Electric Power Research Institute (EPRI), Sandia National Laboratories (SNL) with the U.S. Department of Energy (DOE), and the Solar Electric Power Association (SEPA) initiated a large industry collaborative to identify and standardize definitions for a set of DER grid support functions. While the initial effort concentrated on grid-tied PV inverters and energy storage systems, the concepts have applicability to all DER. A partial product of this on-going effort is a reference definitions document (IEC TR 61850-90-7, Object models for power converters in distributed energy resources (DER) systems) that has become a basis for expansion of related International Electrotechnical Commission (IEC) standards, and is supported by US National Institute of Standards and Technology (NIST) Smart Grid Interoperability Panel (SGIP). Some industry-led organizations advancing communications protocols have also embraced this work. As standards continue to evolve, it is necessary to develop test protocols to independently verify that the inverters are properly executing the advanced functions. Interoperability is assured by establishing common definitions for the functions and a method to test compliance with operational requirements. This document describes test protocols developed by SNL to evaluate the electrical performance and operational capabilities of PV inverters and energy storage, as described in IEC TR 61850-90-7. While many of these functions are not currently required by existing grid codes or may not be widely available commercially, the industry is rapidly moving in that direction. Interoperability issues are already

  8. Conceptual design study advanced concepts test (ACT) facility

    Energy Technology Data Exchange (ETDEWEB)

    Zaloudek, F.R.

    1978-09-01

    The Advanced Concepts Test (ACT) Project is part of program for developing improved power plant dry cooling systems in which ammonia is used as a heat transfer fluid between the power plant and the heat rejection tower. The test facility will be designed to condense 60,000 lb/hr of exhaust steam from the No. 1 turbine in the Kern Power Plant at Bakersfield, CA, transport the heat of condensation from the condenser to the cooling tower by an ammonia phase-change heat transport system, and dissipate this heat to the environs by a dry/wet deluge tower. The design and construction of the test facility will be the responsibility of the Electric Power Research Institute. The DOE, UCC/Linde, and the Pacific Northwest Laboratories will be involved in other phases of the project. The planned test facilities, its structures, mechanical and electrical equipment, control systems, codes and standards, decommissioning requirements, safety and environmental aspects, and energy impact are described. Six appendices of related information are included. (LCL)

  9. Advanced Rooftop Control (ARC) Retrofit: Field-Test Results

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Weimin; Katipamula, Srinivas; Ngo, Hung; Underhill, Ronald M.; Taasevigen, Danny J.; Lutes, Robert G.

    2013-07-31

    The multi-year research study was initiated to find solutions to improve packaged equipment operating efficiency in the field. Pacific Northwest National Laboratory (PNNL), with funding from the U.S. Department of Energy’s (DOE’s) Building Technologies Office (BTO) and Bonneville Power Administration (BPA) conducted this research, development and demonstration (RD&D) study. Packaged equipment with constant speed supply fans is designed to provide ventilation at the design rate at all times when the fan is operating as required by building code. Although there are a number of hours during the day when a building may not be fully occupied or the need for ventilation is lower than designed, the ventilation rate cannot be adjusted easily with a constant speed fan. Therefore, modulating the supply fan in conjunction with demand controlled ventilation (DCV) will not only reduce the coil energy but also reduce the fan energy. The objective of this multi-year research, development and demonstration project was to determine the magnitude of energy savings achievable by retrofitting existing packaged rooftop air conditioners with advanced control strategies not ordinarily used for packaged units. First, through detailed simulation analysis, it was shown that significant energy (between 24% and 35%) and cost savings (38%) from fan, cooling and heating energy consumption could be realized when packaged air conditioning units with gas furnaces are retrofitted with advanced control packages (combining multi-speed fan control, integrated economizer controls and DCV). The simulation analysis also showed significant savings for heat pumps (between 20% and 60%). The simulation analysis was followed by an extensive field test of a retrofittable advanced rooftop unit (RTU) controller.

  10. Two-Dimensional Mapping of the Calculated Fission Power for the Full-Size Fuel Plate Experiment Irradiated in the Advanced Test Reactor

    Science.gov (United States)

    Chang, G. S.; Lillo, M. A.

    2009-08-01

    The National Nuclear Security Administrations (NNSA) Reduced Enrichment for Research and Test Reactors (RERTR) program assigned to the Idaho National Laboratory (INL) the responsibility of developing and demonstrating high uranium density research reactor fuel forms to enable the use of low enriched uranium (LEU) in research and test reactors around the world. A series of full-size fuel plate experiments have been proposed for irradiation testing in the center flux trap (CFT) position of the Advanced Test Reactor (ATR). These full-size fuel plate tests are designated as the AFIP tests. The AFIP nominal fuel zone is rectangular in shape having a designed length of 21.5-in (54.61-cm), width of 1.6-in (4.064-cm), and uniform thickness of 0.014-in (0.03556-cm). This gives a nominal fuel zone volume of 0.482 in3 (7.89 cm3) per fuel plate. The AFIP test assembly has two test positions. Each test position is designed to hold 2 full-size plates, for a total of 4 full-size plates per test assembly. The AFIP test plates will be irradiated at a peak surface heat flux of about 350 W/cm2 and discharged at a peak U-235 burn-up of about 70 at.%. Based on limited irradiation testing of the monolithic (U-10Mo) fuel form, it is desirable to keep the peak fuel temperature below 250°C to achieve this, it will be necessary to keep plate heat fluxes below 500 W/cm2. Due to the heavy U-235 loading and a plate width of 1.6-in (4.064-cm), the neutron self-shielding will increase the local-to-average-ratio (L2AR) fission power near the sides of the fuel plates. To demonstrate that the AFIP experiment will meet the ATR safety requirements, a very detailed 2-dimensional (2D) Y-Z fission power profile was evaluated in order to best predict the fuel plate temperature distribution. The ability to accurately predict fuel plate power and burnup are essential to both the design of the AFIP tests as well as evaluation of the irradiated fuel performance. To support this need, a detailed MCNP Y

  11. Advanced test accelerator: a high-current induction linac

    Energy Technology Data Exchange (ETDEWEB)

    Cook, E.G.; Birx, D.L.; Reginato, L.L.

    1982-11-01

    The Advanced Test Accelerator (ATA) is a linear induction accelerator being built at Lawrence Livermore National Laboratory. The aim of the ATA, together with its associated physics program is the research and development necessary to resolve whether particle-beam propagation is possible. Since the accelerator is the tool needed to do the basic propagation experiment, many of its design parameters are specified by the physics. The accelerator parameters are: 50 MeV, 10 kA, 70 ns pulse width (FWHM), and a 1 kHz rep-rate during a ten-pulse burst. In addition, beam quality and pulse-to-pulse repeatability must be excellent. The unique features of the accelerator are the 10 kA beam and the 1 kHz burst frequency.

  12. UTILITY ADVANCED TURBINE SYSTEMS(ATS) TECHNOLOGY READINESS TESTING

    Energy Technology Data Exchange (ETDEWEB)

    Kenneth A. Yackly

    2001-06-01

    The following paper provides an overview of GE's H System{trademark} technology, and specifically, the design, development, and test activities associated with the DOE Advanced Turbine Systems (ATS) program. There was intensive effort expended in bringing this revolutionary advanced technology program to commercial reality. In addition to describing the magnitude of performance improvement possible through use of H System{trademark} technology, this paper discusses the technological milestones during the development of the first 9H (50Hz) and 7H (60 Hz) gas turbines. To illustrate the methodical product development strategy used by GE, this paper discusses several technologies that were essential to the introduction of the H System{trademark}. Also included are analyses of the series of comprehensive tests of materials, components and subsystems that necessarily preceded full scale field testing of the H System{trademark}. This paper validates one of the basic premises with which GE started the H System{trademark} development program: exhaustive and elaborate testing programs minimized risk at every step of this process, and increase the probability of success when the H System{trademark} is introduced into commercial service. In 1995, GE, the world leader in gas turbine technology for over half a century, in conjunction with the DOE National Energy Technology Laboratory's ATS program, introduced its new generation of gas turbines. This H System{trademark} technology is the first gas turbine ever to achieve the milestone of 60% fuel efficiency. Because fuel represents the largest individual expense of running a power plant, an efficiency increase of even a single percentage point can substantially reduce operating costs over the life of a typical gas-fired, combined-cycle plant in the 400 to 500 megawatt range. The H System{trademark} is not simply a state-of-the-art gas turbine. It is an advanced, integrated, combined-cycle system in which every

  13. ATM, ATR and DNA-PKcs expressions correlate to adverse clinical outcomes in epithelial ovarian cancers

    Science.gov (United States)

    Abdel-Fatah, Tarek M.A.; Arora, Arvind; Moseley, Paul; Coveney, Clare; Perry, Christina; Johnson, Kerstie; Kent, Christopher; Ball, Graham; Chan, Stephen; Madhusudan, Srinivasan

    2014-01-01

    Background Ataxia-telangiectasia mutated (ATM), ataxia-telangiectasia mutated and rad3 related (ATR) and DNA-dependent protein kinase catalytic sub-unit (DNA-PKcs) play critical roles in DNA damage response (DDR) by linking DNA damage sensing to DDR effectors that regulate cell cycle progression and DNA repair. Our objective was to evaluate if ATM, ATR and DNA-PKcs expressions could predict response to therapy and clinical outcome in epithelial ovarian cancers. Methods We investigated ATM, ATR, and DNA-PKcs expressions in ovarian epithelial cancers [protein expression (n = 194 patients), mRNA expression (n = 156 patients)] and correlated to clinicopathological outcomes as well as expression of X-ray repair cross-complementing protein 1 (XRCC1), cell division cycle-45 (CDC45), cyclin-dependent kinase 1(CDK1) and Ki-67 in tumours. Results High ATM protein expression was associated with serous cystadenocarcinomas (p = 0.021) and platinum resistance (p = 0.017). High DNA-PKcs protein expression was associated with serous cystadenocarcinomas (p = 0.006) and advanced stage tumours (p = 0.018). High ATM protein (p = 0.001), high ATM mRNA (p = 0.018), high DNA-PKcs protein (p = 0.002), high DNA-PKcs mRNA (p = 0.044) and high ATR protein (p = 0.001) expressions are correlated with poor ovarian cancer specific survival (OCSS). In multivariate Cox model, high DNA-PKcs (p = 0.006) and high ATR (p = 0.043) protein expressions remain independently associated with poor OCSS. Conclusions ATM, ATR and DNA-PKcs expressions may have prognostic and predictive significances in epithelial ovarian cancer. General significance The data presented here provides evidence that ATM, ATR and DNA-PKcs involved in DDR are not only promising biomarkers but are also rational targets for personalized therapy in ovarian cancer. PMID:26674120

  14. Advanced Utility Mercury-Sorbent Field-Testing Program

    Energy Technology Data Exchange (ETDEWEB)

    Ronald Landreth

    2007-12-31

    This report summarizes the work conducted from September 1, 2003 through December 31, 2007 on the project entitled Advanced Utility Mercury-Sorbent Field-Testing Program. The project covers the testing at the Detroit Edison St. Clair Plant and the Duke Power Cliffside and Buck Stations. The St. Clair Plant used a blend of subbituminous and bituminous coal and controlled the particulate emissions by means of a cold-side ESP. The Duke Power Stations used bituminous coals and controlled their particulate emissions by means of hot-side ESPs. The testing at the Detroit Edison St. Clair Plant demonstrated that mercury sorbents could be used to achieve high mercury removal rates with low injection rates at facilities that burn subbituminous coal. A mercury removal rate of 94% was achieved at an injection rate of 3 lb/MMacf over the thirty day long-term test. Prior to this test, it was believed that the mercury in flue gas of this type would be the most difficult to capture. This is not the case. The testing at the two Duke Power Stations proved that carbon- based mercury sorbents can be used to control the mercury emissions from boilers with hot-side ESPs. It was known that plain PACs did not have any mercury capacity at elevated temperatures but that brominated B-PAC did. The mercury removal rate varies with the operation but it appears that mercury removal rates equal to or greater than 50% are achievable in facilities equipped with hot-side ESPs. As part of the program, both sorbent injection equipment and sorbent production equipment was acquired and operated. This equipment performed very well during this program. In addition, mercury instruments were acquired for this program. These instruments worked well in the flue gas at the St. Clair Plant but not as well in the flue gas at the Duke Power Stations. It is believed that the difference in the amount of oxidized mercury, more at Duke Power, was the difference in instrument performance. Much of the equipment was

  15. ATM and ATR:Sensing DNA damage

    Institute of Scientific and Technical Information of China (English)

    Jun Yang; Zheng-Ping Xu; Yun Huang; Hope E. Hamrick; Penelope J. Duerksen-Hughes; Ying-Nian Yu

    2004-01-01

    Cellular response to genotoxic stress is a very complex process, and it usually starts with the "sensing" or "detection" of the DNA damage, followed by a series of events that include signal transduction and activation of transcription factors. The activated transcription factors induce expressions of many genes which are involved in cellular functions such as DNA repair, cell cycle arrest, and cell death. There have been extensive studies from multiple disciplines exploring the mechanisms of cellular genotoxic responses, which have resulted in the identification of many cellular components involved in this process, including the mitogen-activated protein kinases (MAPKs) cascade. Although the initial activation of protein kinase cascade is not fully understood,human protein kinases ATM (ataxia-telangiectasia, mutated) and ATR (ATM and Rad3-related) are emerging as potential sensors of DNA damage. Current progresses in ATM/ATR research and related signaling pathways are discussed in this review, in an effort to facilitate a better understanding of genotoxic stress response.

  16. Cultural conditions required for the induction of an adaptive acid-tolerance response (ATR) in Sinorhizobium meliloti and the question as to whether or not the ATR helps rhizobia improve their symbiosis with alfalfa at low pH.

    Science.gov (United States)

    Draghi, Walter O; Del Papa, María Florencia; Pistorio, Mariano; Lozano, Mauricio; de Los Angeles Giusti, María; Torres Tejerizo, Gonzalo A; Jofré, Edgardo; Boiardi, José Luis; Lagares, Antonio

    2010-01-01

    Sinorhizobium meliloti associates with Medicago and Melilotus species to develop nitrogen-fixing symbioses. The agricultural relevance of these associations, the worldwide distribution of acid soils, and the remarkable acid sensitivity of the microsymbiont have all stimulated research on the responses of the symbionts to acid environments. We show here that an adaptive acid-tolerance response (ATR) can be induced in S. meliloti, as shown previously for Sinorhizobium medicae, when the bacteria are grown in batch cultures at the slightly acid pH of 6.1. In marked contrast, no increased tolerance to hydrogen ions is obtained if rhizobia are grown in a chemostat under continuous cultivation at the same pH. The adaptive ATR appears as a complex process triggered by an increased hydrogen-ion concentration, but operative only if other--as yet unknown--concomitant factors that depend on the culture conditions are present (although not provided under continuous cultivation). Although the stability of the ATR and its influence on acid tolerance has been characterized in rhizobia, no data have been available on the effect of the adapted state on symbiosis. Coinoculation experiments showed that acid-adapted indicator rhizobia (ATR+) were present in >90% of the nodules when nodulation was performed at pH 5.6, representing a >30% increase in occupancy compared with a control test. We show that the ATR represents a clear advantage in competing for nodulation at low pH. It is not yet clear whether such an effect results from an improved performance in the acid environment during preinfection, an enhanced ability to initiate infections, or both conditions. The practical use of ATR+ rhizobia will depend on validation experiments with soil microcosms and on field testing, as well as on the possibility of preserving the physiology of ATR+ bacteria in inoculant formulations.

  17. Multivariate analysis of ATR-FTIR spectra for assessment of oil shale organic geochemical properties

    Science.gov (United States)

    Washburn, Kathryn E.; Birdwell, Justin E.

    2013-01-01

    In this study, attenuated total reflectance (ATR) Fourier transform infrared spectroscopy (FTIR) was coupled with partial least squares regression (PLSR) analysis to relate spectral data to parameters from total organic carbon (TOC) analysis and programmed pyrolysis to assess the feasibility of developing predictive models to estimate important organic geochemical parameters. The advantage of ATR-FTIR over traditional analytical methods is that source rocks can be analyzed in the laboratory or field in seconds, facilitating more rapid and thorough screening than would be possible using other tools. ATR-FTIR spectra, TOC concentrations and Rock–Eval parameters were measured for a set of oil shales from deposits around the world and several pyrolyzed oil shale samples. PLSR models were developed to predict the measured geochemical parameters from infrared spectra. Application of the resulting models to a set of test spectra excluded from the training set generated accurate predictions of TOC and most Rock–Eval parameters. The critical region of the infrared spectrum for assessing S1, S2, Hydrogen Index and TOC consisted of aliphatic organic moieties (2800–3000 cm−1) and the models generated a better correlation with measured values of TOC and S2 than did integrated aliphatic peak areas. The results suggest that combining ATR-FTIR with PLSR is a reliable approach for estimating useful geochemical parameters of oil shales that is faster and requires less sample preparation than current screening methods.

  18. Functional toxicology: tools to advance the future of toxicity testing

    Directory of Open Access Journals (Sweden)

    Brandon David Gaytán

    2014-05-01

    Full Text Available The increased presence of chemical contaminants in the environment is an undeniable concern to human health and ecosystems. Historically, by relying heavily upon costly and laborious animal-based toxicity assays, the field of toxicology has often neglected examinations of the cellular and molecular mechanisms of toxicity for the majority of compounds – information that, if available, would strengthen risk assessment analyses. Functional toxicology, where cells or organisms with gene deletions or depleted proteins are used to assess genetic requirements for chemical tolerance, can advance the field of toxicity testing by contributing data regarding chemical mechanisms of toxicity. Functional toxicology can be accomplished using available genetic tools in yeasts, other fungi and bacteria, and eukaryotes of increased complexity, including zebrafish, fruit flies, rodents, and human cell lines. Underscored is the value of using less complex systems such as yeasts to direct further studies in more complex systems such as human cell lines. Functional techniques can yield (1 novel insights into chemical toxicity; (2 pathways and mechanisms deserving of further study; and (3 candidate human toxicant susceptibility or resistance genes.

  19. 77 FR 67557 - Special Conditions: ATR-GIE Avions de Transport Regional, Models ATR42-500 and ATR72-212A...

    Science.gov (United States)

    2012-11-13

    ...-engine, turbo- propeller driven. The Model ATR42-500 has a maximum takeoff weight of 41,005 pounds and an... Privacy Act Statement can be found in the Federal Register published on April 11, 2000 (65 FR...

  20. Design and Status of the NGNP Fuel Experiment AGR-3/4 Irradiated in the Advanced Test Reactor

    Energy Technology Data Exchange (ETDEWEB)

    Blaine Grover

    2012-10-01

    The United States Department of Energy’s Next Generation Nuclear Plant (NGNP) Advanced Gas Reactor (AGR) Fuel Development and Qualification Program will be irradiating up to seven separate low enriched uranium (LEU) tri-isotopic (TRISO) particle fuel (in compact form) experiments in the Advanced Test Reactor (ATR) located at the Idaho National Laboratory (INL). These irradiations and fuel development are being accomplished to support development of the next generation reactors in the United States, and will be irradiated over the next several years to demonstrate and qualify new TRISO coated particle fuel for use in high temperature gas reactors. The goals of the irradiation experiments are to provide irradiation performance data to support fuel process development, to qualify fuel for normal operating conditions, to support development and validation of fuel performance and fission product transport models and codes, and to provide irradiated fuel and materials for post irradiation examination (PIE) and safety testing. The experiments, which will each consist of at least six separate capsules, will be irradiated in an inert sweep gas atmosphere with individual on-line temperature monitoring and control of each capsule. The sweep gas will also have on-line fission product monitoring on its effluent to track performance of the fuel in each individual capsule during irradiation. The first experiment (designated AGR-1) started irradiation in December 2006 and was completed in November 2009. The second experiment (AGR-2) started irradiation in June 2010 and is currently scheduled to be completed in April 2013. The third and fourth experiments have been combined into a single experiment designated AGR-3/4, which started its irradiation in December 2011 and is currently scheduled to be completed in November 2013. Since the purpose of this experiment is to provide data on fission product migration and retention in the NGNP reactor, the design of this experiment is

  1. Pressure-Sensitive Paints Advance Rotorcraft Design Testing

    Science.gov (United States)

    2013-01-01

    The rotors of certain helicopters can spin at speeds as high as 500 revolutions per minute. As the blades slice through the air, they flex, moving into the wind and back out, experiencing pressure changes on the order of thousands of times a second and even higher. All of this makes acquiring a true understanding of rotorcraft aerodynamics a difficult task. A traditional means of acquiring aerodynamic data is to conduct wind tunnel tests using a vehicle model outfitted with pressure taps and other sensors. These sensors add significant costs to wind tunnel testing while only providing measurements at discrete locations on the model's surface. In addition, standard sensor solutions do not work for pulling data from a rotor in motion. "Typical static pressure instrumentation can't handle that," explains Neal Watkins, electronics engineer in Langley Research Center s Advanced Sensing and Optical Measurement Branch. "There are dynamic pressure taps, but your costs go up by a factor of five to ten if you use those. In addition, recovery of the pressure tap readings is accomplished through slip rings, which allow only a limited amount of sensors and can require significant maintenance throughout a typical rotor test." One alternative to sensor-based wind tunnel testing is pressure sensitive paint (PSP). A coating of a specialized paint containing luminescent material is applied to the model. When exposed to an LED or laser light source, the material glows. The glowing material tends to be reactive to oxygen, explains Watkins, which causes the glow to diminish. The more oxygen that is present (or the more air present, since oxygen exists in a fixed proportion in air), the less the painted surface glows. Imaged with a camera, the areas experiencing greater air pressure show up darker than areas of less pressure. "The paint allows for a global pressure map as opposed to specific points," says Watkins. With PSP, each pixel recorded by the camera becomes an optical pressure

  2. ATR FTIR Mapping of Leather Fiber Panels

    Science.gov (United States)

    Tondi, G.; Grünewald, T.; Petutschnigg, A.; Schnabel, T.

    2015-01-01

    Leather fiber panels are very promising materials for many applications, not only for the easy availability of the constituents but also for their outstanding fi re-retardant properties. These innovative composite panels can be an excellent material for building insulation, and in recent times, the interest of industries in this composite board has considerably arisen. For this reason the discrimination of the components in the leather fiber panels is becoming fundamental in order to ensure their homogeneous properties. A method to characterize the surface of these materials is then required. An ATR FTIR mapping system for the leather fiber panels has been performed with a Perkin-Elmer microscope coupled with a Frontier FTIR spectrometer. The system has successfully allowed transforming the optical image to a chemical one. This technique can be considered as a right tool for routine controls of the surface quality, especially when the leather shavings cannot be optically distinguished.

  3. FY 88 laser transport experiments on ATA (Advanced Test Accelerator)

    Energy Technology Data Exchange (ETDEWEB)

    Chambers, F.W.; Boyd, J.K.; Caporaso, G.J.; Chong, Y.P.; Fawley, W.M.; Hildum, J.S.; Lee, P.; Orzechowski, T.J.; Prono, D.S.; Smith, A.C.

    1988-11-01

    An experiment was conducted at the Advanced Test Accelerator (ATA) in the spring/summer of 1988 to study the transport of the ''laser guided'' electron beam through the accelerator and beyond. The electron beam was guided from the /approximately/3.75 MeV point through the accelerator on an ion channel created by firing a KrF laser (248 nm, P approx.100--400 mJ) into a benzene filled (p approx..1 ..mu..) beamline. Beam transport was documented at several locations with a variety of diagnostics for various beam parameters; channel, gas, and laser parameters; and for various machine configurations. The focus of this experiment was to document, understand, and then alter (remove) the time variation in the observed accelerated beam parameters. The temporal variation of the beam manifests itself in several ways as has been documented. Beam radius versus time, R(t), from both bow probe and optical data shows the beam radius expanding by factors of up to several over the 40 ns of beam pulse. When the beam is threaded through any device with a limited acceptance the radius variation is parlayed into a current variation, I(t). This has been documented for transport through the fusible link, rise time sharpener, slits, bends, emittance selectors, and during free expansion. The beam temporal variation in time may be viewed as radius increase or blowup, brightness degradation, or emittance increase. The observations of blowup predate the introduction of the collimator. The observations prior to this experiment were made in the post accelerator transport sections. 9 refs., 4 figs.

  4. The advanced computational testing and simulation toolkit (ACTS)

    Energy Technology Data Exchange (ETDEWEB)

    Drummond, L.A.; Marques, O.

    2002-05-21

    During the past decades there has been a continuous growth in the number of physical and societal problems that have been successfully studied and solved by means of computational modeling and simulation. Distinctively, a number of these are important scientific problems ranging in scale from the atomic to the cosmic. For example, ionization is a phenomenon as ubiquitous in modern society as the glow of fluorescent lights and the etching on silicon computer chips; but it was not until 1999 that researchers finally achieved a complete numerical solution to the simplest example of ionization, the collision of a hydrogen atom with an electron. On the opposite scale, cosmologists have long wondered whether the expansion of the Universe, which began with the Big Bang, would ever reverse itself, ending the Universe in a Big Crunch. In 2000, analysis of new measurements of the cosmic microwave background radiation showed that the geometry of the Universe is flat, and thus the Universe will continue expanding forever. Both of these discoveries depended on high performance computer simulations that utilized computational tools included in the Advanced Computational Testing and Simulation (ACTS) Toolkit. The ACTS Toolkit is an umbrella project that brought together a number of general purpose computational tool development projects funded and supported by the U.S. Department of Energy (DOE). These tools, which have been developed independently, mainly at DOE laboratories, make it easier for scientific code developers to write high performance applications for parallel computers. They tackle a number of computational issues that are common to a large number of scientific applications, mainly implementation of numerical algorithms, and support for code development, execution and optimization. The ACTS Toolkit Project enables the use of these tools by a much wider community of computational scientists, and promotes code portability, reusability, reduction of duplicate efforts

  5. Results of Laboratory Testing of Advanced Power Strips: Preprint

    Energy Technology Data Exchange (ETDEWEB)

    Earle, L.; Sparn, B.

    2012-08-01

    This paper describes the results of a laboratory investigation to evaluate the technical performance of advanced power strip (APS) devices when subjected to a range of home entertainment center and home office usage scenarios.

  6. Advance Noise Control Fan II: Test Rig Fan Risk Management Study

    Science.gov (United States)

    Lucero, John

    2013-01-01

    Since 1995 the Advanced Noise Control Fan (ANCF) has significantly contributed to the advancement of the understanding of the physics of fan tonal noise generation. The 9'x15' WT has successfully tested multiple high speed fan designs over the last several decades. This advanced several tone noise reduction concepts to higher TRL and the validation of fan tone noise prediction codes.

  7. ATR Prohibits Replication Catastrophe by Preventing Global Exhaustion of RPA

    DEFF Research Database (Denmark)

    Toledo Lazaro, Luis Ignacio; Altmeyer, Matthias; Rask, Maj-Britt;

    2013-01-01

    induced breakage of stalled forks even in cells with active ATR. Thus, ATR-mediated suppression of dormant origins shields active forks against irreversible breakage via preventing exhaustion of nuclear RPA. This study elucidates how replicating genomes avoid destabilizing DNA damage. Because cancer cells...... origin firing generates an excess of single-stranded DNA that exhausts the nuclear pool of RPA. Partial reduction of RPA accelerated fork breakage, and forced elevation of RPA was sufficient to delay such "replication catastrophe" even in the absence of ATR activity. Conversely, unscheduled origin firing...

  8. AGR-2 Data Qualification Report for ATR Cycles 147A, 148A, 148B, and 149A

    Energy Technology Data Exchange (ETDEWEB)

    Michael L. Abbott; Keith A. Daum

    2011-08-01

    This report presents the data qualification status of fuel irradiation data from the first four reactor cycles (147A, 148A, 148B, and 149A) of the on-going second Advanced Gas Reactor (AGR-2) experiment as recorded in the NGNP Data Management and Analysis System (NDMAS). This includes data received by NDMAS from the period June 22, 2010 through May 21, 2011. AGR-2 is the second in a series of eight planned irradiation experiments for the AGR Fuel Development and Qualification Program, which supports development of the very high temperature gas-cooled reactor (VHTR) under the Next Generation Nuclear Plant (NGNP) Project. Irradiation of the AGR-2 test train is being performed at the Advanced Test Reactor (ATR) at the Idaho National Laboratory (INL) and is planned for 600 effective full power days (approximately 2.75 calendar years) (PLN-3798). The experiment is intended to demonstrate the performance of UCO (uranium oxycarbide) and UO2 (uranium dioxide) fuel produced in a large coater. Data qualification status of the AGR-1 experiment was reported in INL/EXT-10-17943 (Abbott et al. 2010).

  9. UAV based distributed ATR under realistic simulated environmental effects

    Science.gov (United States)

    Chen, Xiaohan; Gong, Shanshan; Schmid, Natalia A.; Valenti, Matthew C.

    2007-04-01

    Over the past several years, the military has grown increasingly reliant upon the use of unattended aerial vehicles (UAVs) for surveillance missions. There is an increasing trend towards fielding swarms of UAVs operating as large-scale sensor networks in the air. Such systems tend to be used primarily for the purpose of acquiring sensory data with the goal of automatic detection, identification, and tracking objects of interest. These trends have been paralleled by advances in both distributed detection, image/signal processing and data fusion techniques. Furthermore, swarmed UAV systems must operate under severe constraints on environmental conditions and sensor limitations. In this work, we investigate the effects of environmental conditions on target detection and recognition performance in a UAV network. We assume that each UAV is equipped with an optical camera, and use a realistic computer simulation to generate synthetic images. The detection algorithm relies on Haar-based features while the automatic target recognition (ATR) algorithm relies on Bessel K features. The performance of both algorithms is evaluated using simulated images that closely mimic data acquired in a UAV network under realistic environmental conditions. We design several fusion techniques and analyze both the case of a single observation and the case of multiple observations of the same target.

  10. PLS-LS-SVM based modeling of ATR-IR as a robust method in detection and qualification of alprazolam

    Science.gov (United States)

    Parhizkar, Elahehnaz; Ghazali, Mohammad; Ahmadi, Fatemeh; Sakhteman, Amirhossein

    2017-02-01

    According to the United States pharmacopeia (USP), Gold standard technique for Alprazolam determination in dosage forms is HPLC, an expensive and time-consuming method that is not easy to approach. In this study chemometrics assisted ATR-IR was introduced as an alternative method that produce similar results in fewer time and energy consumed manner. Fifty-eight samples containing different concentrations of commercial alprazolam were evaluated by HPLC and ATR-IR method. A preprocessing approach was applied to convert raw data obtained from ATR-IR spectra to normal matrix. Finally, a relationship between alprazolam concentrations achieved by HPLC and ATR-IR data was established using PLS-LS-SVM (partial least squares least squares support vector machines). Consequently, validity of the method was verified to yield a model with low error values (root mean square error of cross validation equal to 0.98). The model was able to predict about 99% of the samples according to R2 of prediction set. Response permutation test was also applied to affirm that the model was not assessed by chance correlations. At conclusion, ATR-IR can be a reliable method in manufacturing process in detection and qualification of alprazolam content.

  11. PLS-LS-SVM based modeling of ATR-IR as a robust method in detection and qualification of alprazolam.

    Science.gov (United States)

    Parhizkar, Elahehnaz; Ghazali, Mohammad; Ahmadi, Fatemeh; Sakhteman, Amirhossein

    2017-02-15

    According to the United States pharmacopeia (USP), Gold standard technique for Alprazolam determination in dosage forms is HPLC, an expensive and time-consuming method that is not easy to approach. In this study chemometrics assisted ATR-IR was introduced as an alternative method that produce similar results in fewer time and energy consumed manner. Fifty-eight samples containing different concentrations of commercial alprazolam were evaluated by HPLC and ATR-IR method. A preprocessing approach was applied to convert raw data obtained from ATR-IR spectra to normal matrix. Finally, a relationship between alprazolam concentrations achieved by HPLC and ATR-IR data was established using PLS-LS-SVM (partial least squares least squares support vector machines). Consequently, validity of the method was verified to yield a model with low error values (root mean square error of cross validation equal to 0.98). The model was able to predict about 99% of the samples according to R(2) of prediction set. Response permutation test was also applied to affirm that the model was not assessed by chance correlations. At conclusion, ATR-IR can be a reliable method in manufacturing process in detection and qualification of alprazolam content. Copyright © 2016 Elsevier B.V. All rights reserved.

  12. Activation of the ATR kinase by the RPA-binding protein ETAA1

    DEFF Research Database (Denmark)

    Haahr, Peter; Hoffmann, Saskia; Tollenaere, Maxim A X;

    2016-01-01

    Activation of the ATR kinase following perturbations to DNA replication relies on a complex mechanism involving ATR recruitment to RPA-coated single-stranded DNA via its binding partner ATRIP and stimulation of ATR kinase activity by TopBP1. Here, we discovered an independent ATR activation pathw...

  13. Nondestructive testing of advanced materials using sensors with metamaterials

    Science.gov (United States)

    Rozina, Steigmann; Narcis Andrei, Danila; Nicoleta, Iftimie; Catalin-Andrei, Tugui; Frantisek, Novy; Stanislava, Fintova; Petrica, Vizureanu; Adriana, Savin

    2016-11-01

    This work presents a method for nondestructive evaluation (NDE) of advanced materials that makes use of the images in near field and the concentration of flux using the phenomenon of spatial resolution. The method allows the detection of flaws as crack, nonadhesion of coating, degradation or presence delamination stresses correlated with the response of electromagnetic sensor.

  14. Advanced RADAR Sensors Modeling for Driving Assistance Systems Testing.

    OpenAIRE

    KEDZIA, Jean-Claude; DESOUZA, Philippe; Gruyer, Dominique

    2016-01-01

    With Advanced Driver Assistance Systems (ADAS) getting always more sophisticated, the related Virtual Prototyping platforms have to propose a very high level of accuracy with improved flexibility regarding vehicles, sensors, environments and scenarios. In this paper a new strategy is introduced for RADAR sensors modeling aimed at allowing high accuracy while limiting the related development efforts.

  15. Advanced Control Design for Wind Turbines; Part I: Control Design, Implementation, and Initial Tests

    Energy Technology Data Exchange (ETDEWEB)

    Wright, A. D.; Fingersh, L. J.

    2008-03-01

    The purpose of this report is to give wind turbine engineers information and examples of the design, testing through simulation, field implementation, and field testing of advanced wind turbine controls.

  16. Dual inhibition of ATR and ATM potentiates the activity of trabectedin and lurbinectedin by perturbing the DNA damage response and homologous recombination repair.

    Science.gov (United States)

    Lima, Michelle; Bouzid, Hana; Soares, Daniele G; Selle, Frédéric; Morel, Claire; Galmarini, Carlos M; Henriques, João A P; Larsen, Annette K; Escargueil, Alexandre E

    2016-05-03

    Trabectedin (Yondelis®, ecteinascidin-743, ET-743) is a marine-derived natural product approved for treatment of advanced soft tissue sarcoma and relapsed platinum-sensitive ovarian cancer. Lurbinectedin is a novel anticancer agent structurally related to trabectedin. Both ecteinascidins generate DNA double-strand breaks that are processed through homologous recombination repair (HRR), thereby rendering HRR-deficient cells particularly sensitive. We here characterize the DNA damage response (DDR) to trabectedin and lurbinectedin in HeLa cells. Our results show that both compounds activate the ATM/Chk2 (ataxia-telangiectasia mutated/checkpoint kinase 2) and ATR/Chk1 (ATM and RAD3-related/checkpoint kinase 1) pathways. Interestingly, pharmacological inhibition of Chk1/2, ATR or ATM is not accompanied by any significant improvement of the cytotoxic activity of the ecteinascidins while dual inhibition of ATM and ATR strongly potentiates it. Accordingly, concomitant inhibition of both ATR and ATM is an absolute requirement to efficiently block the formation of γ-H2AX, MDC1, BRCA1 and Rad51 foci following exposure to the ecteinascidins. These results are not restricted to HeLa cells, but are shared by cisplatin-sensitive and -resistant ovarian carcinoma cells. Together, our data identify ATR and ATM as central coordinators of the DDR to ecteinascidins and provide a mechanistic rationale for combining these compounds with ATR and ATM inhibitors.

  17. ATR National Scientific User Facility 2009 Annual Report

    Energy Technology Data Exchange (ETDEWEB)

    Todd R. Allen; Mitchell K. Meyer; Frances Marshall; Mary Catherine Thelen; Jeff Benson

    2010-11-01

    This report describes activities of the ATR NSUF from FY-2008 through FY-2009 and includes information on partner facilities, calls for proposals, users week and education programs. The report also contains project information on university research projects that were awarded by ATR NSUF in the fiscal years 2008 & 2009. This research is university-proposed researcher under a user facility agreement. All intellectual property from these experiments belongs to the university per the user agreement.

  18. Advanced stellar compass deep space navigation, ground testing results

    DEFF Research Database (Denmark)

    Betto, Maurizio; Jørgensen, John Leif; Jørgensen, Peter Siegbjørn

    2006-01-01

    Deep space exploration is in the agenda of the major space agencies worldwide and at least the European Space Agency (SMART & Aurora Programs) and the American NASA (New Millennium Program) have set up programs to allow the development and the demonstration of technologies that can reduce the risks...... and the costs of the deep space missions. Navigation is the Achilles' heel of deep space. Being performed on ground, it imposes considerable constraints on the system and the operations, it is very expensive to execute, especially when the mission lasts several years and, above all, it is not failure tolerant....... Nevertheless, up to now, ground navigation has been the only possible solution. The technological breakthrough of advanced star trackers, like the micro-advanced stellar compass (mu ASC) might change this situation. Indeed, exploiting the capabilities of this instrument, the authors have devised a method...

  19. Beta Test Plan for Advanced Inverters Interconnecting Distributed Resources with Electric Power Systems

    Energy Technology Data Exchange (ETDEWEB)

    Hoke, A.; Chakraborty, S.; Basso, T.; Coddington, M.

    2014-01-01

    This document provides a preliminary (beta) test plan for grid interconnection systems of advanced inverter-based DERs. It follows the format and methodology/approach established by IEEE Std 1547.1, while incorporating: 1. Upgraded tests for responses to abnormal voltage and frequency, and also including ride-through. 2. A newly developed test for voltage regulation, including dynamic response testing. 3. Modified tests for unintentional islanding, open phase, and harmonics to include testing with the advanced voltage and frequency response functions enabled. Two advanced inverters, one single-phase and one three-phase, were tested under the beta test plan. These tests confirmed the importance of including tests for inverter dynamic response, which varies widely from one inverter to the next.

  20. Experiment Safety Assurance Package for Mixed Oxide Fuel Irradiation in an Average Power Position (I-24) in the Advanced Test Reactor

    Energy Technology Data Exchange (ETDEWEB)

    J. M . Ryskamp; R. C. Howard; R. C. Pedersen; S. T. Khericha

    1998-10-01

    The Fissile Material Disposition Program Light Water Reactor Mixed Oxide Fuel Irradiation Test Project Plan details a series of test irradiations designed to investigate the use of weapons-grade plutonium in MOX fuel for light water reactors (LWR) (Cowell 1996a, Cowell 1997a, Thoms 1997a). Commercial MOX fuel has been successfully used in overseas reactors for many years; however, weapons-derived test fuel contains small amounts of gallium (about 2 parts per million). A concern exists that the gallium may migrate out of the fuel and into the clad, inducing embrittlement. For preliminary out-of-pile experiments, Wilson (1997) states that intermetallic compound formation is the principal interaction mechanism between zircaloy cladding and gallium. This interaction is very limited by the low mass of gallium, so problems are not expected with the zircaloy cladding, but an in-pile experiment is needed to confirm the out-of-pile experiments. Ryskamp (1998) provides an overview of this experiment and its documentation. The purpose of this Experiment Safety Assurance Package (ESAP) is to demonstrate the safe irradiation and handling of the mixed uranium and plutonium oxide (MOX) Fuel Average Power Test (APT) experiment as required by Advanced Test Reactor (ATR) Technical Safety Requirement (TSR) 3.9.1 (LMITCO 1998). This ESAP addresses the specific operation of the MOX Fuel APT experiment with respect to the operating envelope for irradiation established by the Upgraded Final Safety Analysis Report (UFSAR) Lockheed Martin Idaho Technologies Company (LMITCO 1997a). Experiment handling activities are discussed herein.

  1. Optimization of Adaboost Algorithm for Sonar Target Detection in a Multi-Stage ATR System

    Science.gov (United States)

    Lin, Tsung Han (Hank)

    2011-01-01

    JPL has developed a multi-stage Automated Target Recognition (ATR) system to locate objects in images. First, input images are preprocessed and sent to a Grayscale Optical Correlator (GOC) filter to identify possible regions-of-interest (ROIs). Second, feature extraction operations are performed using Texton filters and Principal Component Analysis (PCA). Finally, the features are fed to a classifier, to identify ROIs that contain the targets. Previous work used the Feed-forward Back-propagation Neural Network for classification. In this project we investigate a version of Adaboost as a classifier for comparison. The version we used is known as GentleBoost. We used the boosted decision tree as the weak classifier. We have tested our ATR system against real-world sonar images using the Adaboost approach. Results indicate an improvement in performance over a single Neural Network design.

  2. Attenuated total reflection infrared spectroscopy (ATR-IR) as an in situ technique for dissolution studies.

    Science.gov (United States)

    Kassis, Abe; Bhawtankar, Vrushali M; Sowa, John R

    2010-11-02

    Dissolution studies are critical tests for measuring the performance of a drug product. We have developed a novel technique using in situ ATR-IR spectroscopy to monitor dissolutions of pharmaceutical drug products. The accuracy of this technique is +/-3% relative to HPLC using salicylic acid calibrator tablets and acetaminophen OTC tablets. This novel approach also gives the research laboratory the capability of analyzing individual ingredients in multiple tablets; for example, individual components of salicylic acid and acetaminophen tablets are easily distinguished. In addition, the individual ingredients of a multi-component tablet containing acetylsalicylic acid and acetaminophen are readily distinguished. The ATR-IR system was found to have good sensitivity and can analyze samples as low as 0.03 mg/ml. With improved sensitivity, this is a promising method for monitoring dissolution of pharmaceutical tablets with an excellent in situ capability for distinguishing individual components. Copyright (c) 2010 Elsevier B.V. All rights reserved.

  3. Engineer Design Test 2 Hughes YAH-64 Advanced Attack Helicopter

    Science.gov (United States)

    1979-06-01

    Flight test data were obtained from calibrated test instrumentat ion and were recorded on magnetic tape. Real time telemetry was used to nionitor...performance measurements were made with the I111 Black lHole Ocarina (B-1O) infrared suppressor system installed. Performance data presented in this...Dynamic stability tests were discontinued after 2 oscillations at 136 KCAS 12 .. ... .. . . .. . .. ..... ... . - due to sideslip limits. Typical time

  4. Ability evaluation by binary tests: Problems, challenges & recent advances

    Science.gov (United States)

    Bashkansky, E.; Turetsky, V.

    2016-11-01

    Binary tests designed to measure abilities of objects under test (OUTs) are widely used in different fields of measurement theory and practice. The number of test items in such tests is usually very limited. The response to each test item provides only one bit of information per OUT. The problem of correct ability assessment is even more complicated, when the levels of difficulty of the test items are unknown beforehand. This fact makes the search for effective ways of planning and processing the results of such tests highly relevant. In recent years, there has been some progress in this direction, generated by both the development of computational tools and the emergence of new ideas. The latter are associated with the use of so-called “scale invariant item response models”. Together with maximum likelihood estimation (MLE) approach, they helped to solve some problems of engineering and proficiency testing. However, several issues related to the assessment of uncertainties, replications scheduling, the use of placebo, as well as evaluation of multidimensional abilities still present a challenge for researchers. The authors attempt to outline the ways to solve the above problems.

  5. Advances in the analysis of pressure interference tests

    Energy Technology Data Exchange (ETDEWEB)

    Martinez R, N. [Petroleos Mexicanos, PEMEX, Mexico City (Mexico); Samaniego V, F. [Univ. Nacional Autonoma de Mexico (Mexico)

    2010-12-15

    This paper presented an extension for radial, linear, and spherical flow conditions of the El-Khatib method for analyzing pressure interference tests through utilization of the pressure derivative. Conventional analysis of interference tests considers only radial flow, but some reservoirs have physical field conditions in which linear or spherical flow conditions prevail. The INTERFERAN system, a friendly computer code for the automatic analysis of pressure interference tests, was also discussed and demonstrated by way of 2 field cases. INTERFERAN relies on the principle of superposition in time and space to interpret a test of several wells with variable histories of production or injection or both. The first field case addressed interference tests conducted in the naturally fractured geothermal field of Klamath Falls, and the second field case was conducted in a river-formed bed in which linear flow conditions are dominant. The analysis was deemed to be reliable. 13 refs., 1 tab., 7 figs.

  6. Advanced WEC Dynamics & Controls FY16 Testing Report

    Energy Technology Data Exchange (ETDEWEB)

    Coe, Ryan Geoffrey [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Bacelli, Giorgio [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Wilson, David G. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Patterson, David Charles [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2016-10-01

    A model-scale wave tank test was conducted in the interest of improving control systems design of wave energy converters (WECs). The success of most control strategies is based directly upon the availability of a reduced-order model with the ability to capture the dynamics of the system with sufficient accuracy. For this reason, the test described in this report, which is the first in a series of planned tests on WEC controls, focused on system identification (system ID) and model validation.

  7. Advances in isotopic analysis for food authenticity testing

    DEFF Research Database (Denmark)

    Laursen, Kristian Holst; Bontempo, L.; Camin, Federica

    2016-01-01

    Abstract Stable isotope analysis has been used for food authenticity testing for more than 30 years and is today being utilized on a routine basis for a wide variety of food commodities. During the past decade, major analytical method developments have been made and the fundamental understanding...... authenticity testing is currently developing even further. In this chapter, we aim to provide an overview of the latest developments in stable isotope analysis for food authenticity testing. As several review articles and book chapters have recently addressed this topic, we will primarily focus on relevant...... literature from the past 5 years. We will focus on well-established methods for food authenticity testing using stable isotopes but will also include recent methodological developments, new applications, and current and future challenges....

  8. ATR-FTIR spectroscopy and chemometrics: An interesting tool to discriminate and characterize counterfeit medicines.

    Science.gov (United States)

    Custers, D; Cauwenbergh, T; Bothy, J L; Courselle, P; De Beer, J O; Apers, S; Deconinck, E

    2015-08-10

    Counterfeit medicines pose a huge threat to public health worldwide. High amounts of counterfeit pharmaceuticals enter the European market and therefore detection of these products is essential. Attenuated Total Reflection Fourier-Transform infrared spectroscopy (ATR-FTIR) might be useful for the screening of counterfeit medicines since it is easy to use and little sample preparation is required. Furthermore, this approach might be helpful to customs to obtain a first evaluation of suspected samples. This study proposes a combination of ATR-FTIR and chemometrics to discriminate and classify counterfeit medicines. A sample set, containing 209 samples in total, was analyzed using ATR-FTIR and the obtained spectra were used as fingerprints in the chemometric data-analysis which included Principal Component Analysis (PCA), k-Nearest Neighbours (k-NN), Classification and Regression Trees (CART) and Soft Independent Modelling of Class Analogy (SIMCA). First it was verified whether the mentioned techniques are capable to distinguish samples containing different active pharmaceutical ingredients (APIs). PCA showed a clear tendency of discrimination based on the API present; k-NN, CART and SIMCA were capable to create suitable prediction models based on the presence of different APIs. However k-NN performs the least while SIMCA performs the best. Secondly, it was tested whether these three models could be expanded to discriminate between genuine and counterfeit samples as well. k-NN was not able to make the desired discrimination and therefore it was not useful. CART performed better but also this model was less suited. SIMCA, on the other hand, resulted in a model with a 100% correct discrimination between genuine and counterfeit drugs. This study shows that chemometric analysis of ATR-FTIR fingerprints is a valuable tool to discriminate genuine from counterfeit samples and to classify counterfeit medicines. Copyright © 2014 Elsevier B.V. All rights reserved.

  9. The detection and discrimination of human body fluids using ATR FT-IR spectroscopy.

    Science.gov (United States)

    Orphanou, Charlotte-Maria; Walton-Williams, Laura; Mountain, Harry; Cassella, John

    2015-07-01

    Blood, saliva, semen and vaginal secretions are the main human body fluids encountered at crime scenes. Currently presumptive tests are routinely utilised to indicate the presence of body fluids, although these are often subject to false positives and limited to particular body fluids. Over the last decade more sensitive and specific body fluid identification methods have been explored, such as mRNA analysis and proteomics, although these are not yet appropriate for routine application. This research investigated the application of ATR FT-IR spectroscopy for the detection and discrimination of human blood, saliva, semen and vaginal secretions. The results demonstrated that ATR FT-IR spectroscopy can detect and distinguish between these body fluids based on the unique spectral pattern, combination of peaks and peak frequencies corresponding to the macromolecule groups common within biological material. Comparisons with known abundant proteins relevant to each body fluid were also analysed to enable specific peaks to be attributed to the relevant protein components, which further reinforced the discrimination and identification of each body fluid. Overall, this preliminary research has demonstrated the potential for ATR FT-IR spectroscopy to be utilised in the routine confirmatory screening of biological evidence due to its quick and robust application within forensic science.

  10. An add-on cap for ATR-IR spectroscopy studies

    DEFF Research Database (Denmark)

    2014-01-01

    The invention relates to a cap (300B) for an attenuated total reflectance infrared (ATR-IR) spectrometer, the ATR-IR spectrometer comprising an ATR-IR plate (200). The cap (300B) comprises an ATR- IR plate facing cap surface. When the ATR-IR plate facing cap surface is placed on the sample surface...... side of the ATR-IR plate (200), a sample cavity enclosing the sample is formed between the sample surface side of the ATR-IR plate (200) and the ATR-IR plate facing cap surface of the cap (300B). This sample cavity can be an air tight cavity. The cap may further comprise a bridge (322), which functions...... as cap securing means (322), as the cap (300B) is secured onto the ATR-IR plate (200) by a pressure clamp (108) and an arm (110) holding the pressure clamp (108) pressing on the bridge (322)....

  11. Advances in Fecal Occult Blood Tests: The FIT Revolution

    NARCIS (Netherlands)

    G.P. Young; E.L. Symonds (Erin L.); J.E. Allison (James E.); S.R. Cole (Stephen R.); C.G. Fraser (Callum G.); S. Halloran (S.); E.J. Kuipers (Ernst); H.E. Seaman (Helen E.)

    2015-01-01

    textabstractThere is a wide choice of fecal occult blood tests (FOBTs) for colorectal cancer screening. Goal: To highlight the issues applicable when choosing a FOBT, in particular which FOBT is best suited to the range of screening scenarios. Four scenarios characterize the constraints and expectat

  12. "ATR activation in response to ionizing radiation: still ATM territory"

    Directory of Open Access Journals (Sweden)

    Cuadrado Myriam

    2006-05-01

    Full Text Available Abstract Unrepaired DNA double-strand breaks (DSBs are a major cause for genomic instability. Therefore, upon detection of a DSB a rapid response must be assembled to coordinate the proper repair/signaling of the lesion or the elimination of cells with unsustainable amounts of DNA damage. Three members of the PIKK family of protein kinases -ATM, ATR and DNA-PKcs- take the lead and initiate the signaling cascade emanating from DSB sites. Whereas DNA-PKcs activity seems to be restricted to the phosphorylation of targets involved in DNA repair, ATM and ATR phosphorylate a broad spectrum of cell cycle regulators and DNA repair proteins. In the canonical model, ATM and ATR are activated by two different types of lesions and signal through two independent and alternate pathways. Specifically, ATR is activated by various forms of DNA damage, including DSBs, arising at stalled replication forks ("replication stress", and ATM is responsible for the signaling of DSBs that are not associated with the replication machinery throughout the cell cycle. Recent evidence suggests that this model might be oversimplified and that coordinated crosstalk between ATM and ATR activation routes goes on at the core of the DNA damage response.

  13. Advanced Background Subtraction Applied to Aeroacoustic Wind Tunnel Testing

    Science.gov (United States)

    Bahr, Christopher J.; Horne, William C.

    2015-01-01

    An advanced form of background subtraction is presented and applied to aeroacoustic wind tunnel data. A variant of this method has seen use in other fields such as climatology and medical imaging. The technique, based on an eigenvalue decomposition of the background noise cross-spectral matrix, is robust against situations where isolated background auto-spectral levels are measured to be higher than levels of combined source and background signals. It also provides an alternate estimate of the cross-spectrum, which previously might have poor definition for low signal-to-noise ratio measurements. Simulated results indicate similar performance to conventional background subtraction when the subtracted spectra are weaker than the true contaminating background levels. Superior performance is observed when the subtracted spectra are stronger than the true contaminating background levels. Experimental results show limited success in recovering signal behavior for data where conventional background subtraction fails. They also demonstrate the new subtraction technique's ability to maintain a proper coherence relationship in the modified cross-spectral matrix. Beam-forming and de-convolution results indicate the method can successfully separate sources. Results also show a reduced need for the use of diagonal removal in phased array processing, at least for the limited data sets considered.

  14. Classification methods for noise transients in advanced gravitational-wave detectors II: performance tests on Advanced LIGO data

    Science.gov (United States)

    Powell, Jade; Torres-Forné, Alejandro; Lynch, Ryan; Trifirò, Daniele; Cuoco, Elena; Cavaglià, Marco; Heng, Ik Siong; Font, José A.

    2017-02-01

    The data taken by the advanced LIGO and Virgo gravitational-wave detectors contains short duration noise transients that limit the significance of astrophysical detections and reduce the duty cycle of the instruments. As the advanced detectors are reaching sensitivity levels that allow for multiple detections of astrophysical gravitational-wave sources it is crucial to achieve a fast and accurate characterization of non-astrophysical transient noise shortly after it occurs in the detectors. Previously we presented three methods for the classification of transient noise sources. They are Principal Component Analysis for Transients (PCAT), Principal Component LALInference Burst (PC-LIB) and Wavelet Detection Filter with Machine Learning (WDF-ML). In this study we carry out the first performance tests of these algorithms on gravitational-wave data from the Advanced LIGO detectors. We use the data taken between the 3rd of June 2015 and the 14th of June 2015 during the 7th engineering run (ER7), and outline the improvements made to increase the performance and lower the latency of the algorithms on real data. This work provides an important test for understanding the performance of these methods on real, non stationary data in preparation for the second advanced gravitational-wave detector observation run, planned for later this year. We show that all methods can classify transients in non stationary data with a high level of accuracy and show the benefits of using multiple classifiers.

  15. Microstructural Characterization of a Mg Matrix U-Mo Dispersion Fuel Plate Irradiated in the Advanced Test Reactor to High Fission Density: SEM Results

    Science.gov (United States)

    Keiser, Dennis D.; Jue, Jan-Fong; Miller, Brandon D.; Gan, Jian; Robinson, Adam B.; Medvedev, Pavel G.; Madden, James W.; Moore, Glenn A.

    2016-06-01

    Low-enriched (U-235 reactors. In most cases, fuel plates with Al or Al-Si alloy matrices have been tested in the Advanced Test Reactor to support this development. In addition, fuel plates with Mg as the matrix have also been tested. The benefit of using Mg as the matrix is that it potentially will not chemically interact with the U-Mo fuel particles during fabrication or irradiation, whereas with Al and Al-Si alloys such interactions will occur. Fuel plate R9R010 is a Mg matrix fuel plate that was aggressively irradiated in ATR. This fuel plate was irradiated as part of the RERTR-8 experiment at high temperature, high fission rate, and high power, up to high fission density. This paper describes the results of the scanning electron microscopy (SEM) analysis of an irradiated fuel plate using polished samples and those produced with a focused ion beam. A follow-up paper will discuss the results of transmission electron microscopy (TEM) analysis. Using SEM, it was observed that even at very aggressive irradiation conditions, negligible chemical interaction occurred between the irradiated U-7Mo fuel particles and Mg matrix; no interconnection of fission gas bubbles from fuel particle to fuel particle was observed; the interconnected fission gas bubbles that were observed in the irradiated U-7Mo particles resulted in some transport of solid fission products to the U-7Mo/Mg interface; the presence of microstructural pathways in some U-9.1 Mo particles that could allow for transport of fission gases did not result in the apparent presence of large porosity at the U-7Mo/Mg interface; and, the Mg-Al interaction layers that were present at the Mg matrix/Al 6061 cladding interface exhibited good radiation stability, i.e. no large pores.

  16. Acceptance Test Report for the 241-AN-107 Enraf Advanced Technology Gauges

    Energy Technology Data Exchange (ETDEWEB)

    Dowell, J.L.; Enderlin, V.R.

    1995-06-01

    This Acceptance Test Report covers the results of the execution of the Acceptance Test Procedure for the 241-AN-107 Enraf Advanced Technology Gauges. The test verified the proper operation of the gauges to measure waste density and level in the 241-AN-107 tank.

  17. Nondestructive Testing of Advanced Concrete Structure during Lifetime

    Directory of Open Access Journals (Sweden)

    Lubos Pazdera

    2015-01-01

    Full Text Available The paper reports on measurements and analysis of the measurements during hardening and drying of specimens using selected acoustic nondestructive testing techniques. An integrated approach was created for better understanding of the relations between the lifetime cycle and the development of the mechanical properties of concrete. Acoustic emission, impact echo, and ultrasonic techniques were applied simultaneously to the same mixtures. These techniques and results are presented on alkali-activated slag mortars. The acoustic emission method detects transient elastic waves within the material, caused by the release of cumulated stress energy, which can be mechanical, thermal, or chemical. Hence, the cause is a phenomenon which releases elastic energy into the material, which then spreads in the form of an elastic wave. The impact echo method is based on physical laws of elastic stress wave propagation in solids generated by mechanical impulse. Ultrasonic testing is commonly used to find flaws in materials or to assess wave velocity spreading.

  18. Mechanical testing of advanced coating system, volume 1

    Science.gov (United States)

    Cruse, T. A.; Nagy, A.; Popelar, C. F.

    1990-01-01

    The Electron Beam Physical Vapor Deposition (EBPVD) coating material has a highly columnar microstructure, and as a result it was expected to have very low tensile strength. To be able to fabricate the required compression and tensile specimens, a substrate was required to provide structural integrity for the specimens. Substrate and coating dimensions were adjusted to provide sufficient sensitivity to resolve the projected loads carried by the EBPVD coating. The use of two distinctively different strain transducer systems, for tension and compression loadings, mandated two vastly different specimen geometries. Compression specimen and tensile specimen geometries are given. Both compression and tensile test setups are described. Data reduction mathematical models are given and discussed in detail as is the interpretation of the results. Creep test data is also given and discussed.

  19. Advanced Development of Leishmania Topical Skin Test Antigen

    Science.gov (United States)

    2012-09-28

    followed to assess the effectiveness of the cleaning and sanitization procedures. The filling, capping and assembly of final containers occurred in Class...disappeared after several days in both subjects. Topical steroid cream was administered to one subject to promote resolution. 2.5.2 Phase II Dose...al. (3) studied the effects of repeat skin tests in healthy volunteers residing in a leishmaniasis non-endemic area. The Leishmnaia antigen used in

  20. Validation Testing and Numerical Modeling of Advanced Armor Materials

    Science.gov (United States)

    2012-11-01

    during the time of this investigation, we chose 6061-T6 to represent the matrix because it is representative of a non- ferrous light aluminum alloy metal...and consist of a strengthening component embedded in an aluminum alloy matrix. For this study, we perform Taylor impact tests on a unique...aluminum alloy only. We perform a detailed analysis of the deformed specimen shapes to determine the dynamic yield strength. Additionally, hydrocode

  1. Multi-Purpose Thermal Hydraulic Loop: Advanced Reactor Technology Integral System Test (ARTIST) Facility for Support of Advanced Reactor Technologies

    Energy Technology Data Exchange (ETDEWEB)

    James E. O' Brien; Piyush Sabharwall; SuJong Yoon

    2001-11-01

    Effective and robust high temperature heat transfer systems are fundamental to the successful deployment of advanced reactors for both power generation and non-electric applications. Plant designs often include an intermediate heat transfer loop (IHTL) with heat exchangers at either end to deliver thermal energy to the application while providing isolation of the primary reactor system. In order to address technical feasibility concerns and challenges a new high-temperature multi-fluid, multi-loop test facility “Advanced Reactor Technology Integral System Test facility” (ARTIST) is under development at the Idaho National Laboratory. The facility will include three flow loops: high-temperature helium, molten salt, and steam/water. Details of some of the design aspects and challenges of this facility, which is currently in the conceptual design phase, are discussed

  2. Testing of an advanced thermochemical conversion reactor system

    Science.gov (United States)

    1990-01-01

    This report presents the results of work conducted by MTCI to verify and confirm experimentally the ability of the MTCI gasification process to effectively generate a high-quality, medium-Btu gas from a wider variety of feedstock and waste than that attainable in air-blown, direct gasification systems. The system's overall simplicity, due to the compact nature of the pulse combustor, and the high heat transfer rates attainable within the pulsating flow resonance tubes, provide a decided and near-term potential economic advantage for the MTCI indirect gasification system. The primary objective was the design, construction, and testing of a Process Design Verification System for an indirectly heated, thermochemical fluid-bed reactor and a pulse combustor an an integrated system that can process alternative renewable sources of energy such as biomass, black liquor, municipal solid waste and waste hydrocarbons, including heavy oils into a useful product gas. The test objectives for the biomass portion of this program were to establish definitive performance data on biomass feedstocks covering a wide range of feedstock qualities and characteristics. The test objectives for the black liquor portion of this program were to verify the operation of the indirect gasifier on commercial black liquor containing 65 percent solids at several temperature levels and to characterize the bed carbon content, bed solids particle size and sulfur distribution as a function of gasification conditions.

  3. Testing of an advanced thermochemical conversion reactor system

    Energy Technology Data Exchange (ETDEWEB)

    1990-01-01

    This report presents the results of work conducted by MTCI to verify and confirm experimentally the ability of the MTCI gasification process to effectively generate a high-quality, medium-Btu gas from a wider variety of feedstock and waste than that attainable in air-blown, direct gasification systems. The system's overall simplicity, due to the compact nature of the pulse combustor, and the high heat transfer rates attainable within the pulsating flow resonance tubes, provide a decided and near-term potential economic advantage for the MTCI indirect gasification system. The primary objective of this project was the design, construction, and testing of a Process Design Verification System for an indirectly heated, thermochemical fluid-bed reactor and a pulse combustor an an integrated system that can process alternative renewable sources of energy such as biomass, black liquor, municipal solid waste and waste hydrocarbons, including heavy oils into a useful product gas. The test objectives for the biomass portion of this program were to establish definitive performance data on biomass feedstocks covering a wide range of feedstock qualities and characteristics. The test objectives for the black liquor portion of this program were to verify the operation of the indirect gasifier on commercial black liquor containing 65 percent solids at several temperature levels and to characterize the bed carbon content, bed solids particle size and sulfur distribution as a function of gasification conditions. 6 refs., 59 figs., 29 tabs.

  4. Designing and Testing Contols to Mitigate Dynamic Loads in the Controls Advanced Research Turbine: Preprint

    Energy Technology Data Exchange (ETDEWEB)

    Wright, A.D.; Stol, K.A.

    2008-01-01

    The National Renewable Energy Laboratory is designing, implementing, and testing advanced controls to maximize energy extraction and reduce structural dynamic loads of wind turbines. These control designs are based on a linear model of the turbine that is generated by specialized modeling software. In this paper, we show the design and simulation testing of a control algorithm to mitigate blade, tower, and drivetrain loads using advanced state-space control design methods.

  5. Investigation of advanced reburning in a bench scale test facility

    Energy Technology Data Exchange (ETDEWEB)

    Gruel, U.; Spliethoff, H.; Hein, K.R.G. [Universitaet Stuttgart, Stuttgart (Germany). Inst. fuer Verfahrenstechnik und Dampfkesselwesen

    1998-12-31

    Interest in Germany in NO{sub x} control is high, and German emissions standards are among the most stringent. Because there is no direct relationship between coal nitrogen and NO{sub x} combustion conditions are of major influence on the NO{sub x} emissions. The control of NO{sub x} emissions by modifications of the combustion process is challenging. In the first period of the project, baseline investigations were carried out using black coal concerning unstaged combustion as well as air and fuel staged combustion to determine the boundary conditions at the test facility and to allow the comparison of different facilities. In the second period of the project, baseline tests with addition of ammonia in the unstaged air and fuel-staged combustion were carried out. The effects of temperature and stoichiometry in the reduction zone were investigated, as well as the influence of the reburn gas composition. Profile measurements of the gaseous species and the temperature in the flue gas explained the negative effect of pre-mixed methane and ammonia as reburn fuel for NO{sub x} reduction. Pre-mixed methane and ammonia performed poorly for NO{sub x} reduction, in some cases NO{sub x} emissions even increased through ammonia addition. In the third period of the project, test runs with methane as reburn fuel and ammonia injection in the substoichiometric reduction zone were conducted. The main purpose was to determine the minimum and the most effective residence time between reburn fuel and ammonia addition at which no NO formation out of the oxygen remaining from the primary zone would take place. Also important was the minimum residence time between ammonia injection and burnout air addition. 5 refs., 22 figs., 7 tabs.

  6. Advanced stellar compass deep space navigation, ground testing results

    DEFF Research Database (Denmark)

    Betto, Maurizio; Jørgensen, John Leif; Jørgensen, Peter Siegbjørn

    2006-01-01

    Deep space exploration is in the agenda of the major space agencies worldwide and at least the European Space Agency (SMART & Aurora Programs) and the American NASA (New Millennium Program) have set up programs to allow the development and the demonstration of technologies that can reduce the ris...... to determine the orbit of a spacecraft autonomously, on-board and without any a priori knowledge of any kind. The solution is robust, elegant and fast. This paper presents the preliminary performances obtained during the ground tests. The results are very positive and encouraging....

  7. JV Task - 129 Advanced Conversion Test - Bulgarian Lignite

    Energy Technology Data Exchange (ETDEWEB)

    Michael Swanson; Everett Sondreal; Daniel Laudal; Douglas Hajicek; Ann Henderson; Brandon Pavlish

    2009-03-27

    The objectives of this Energy & Environmental Research Center (EERC) project were to evaluate Bulgarian lignite performance under both fluid-bed combustion and gasification conditions and provide a recommendation as to which technology would be the most technically feasible for the particular feedstock and also identify any potential operating issues (such as bed agglomeration, etc.) that may limit the applicability of a potential coal conversion technology. Gasification tests were run at the EERC in the 100-400-kg/hr transport reactor development unit (TRDU) on a 50-tonne sample of lignite supplied by the Bulgarian Lignite Power Project. The quality of the test sample was inferior to any coal previously tested in this unit, containing 50% ash at 26.7% moisture and having a higher heating value of 5043 kJ/kg after partial drying in preparation for testing. The tentative conclusion reached on the basis of tests in the TRDU is that oxygen-blown gasification of this high-ash Bulgarian lignite sample using the Kellogg, Brown, and Root (KBR) transport gasifier technology would not provide a syngas suitable for directly firing a gas turbine. After correcting for test conditions specific to the pilot-scale TRDU, including an unavoidably high heat loss and nitrogen dilution by transport air, the best-case heating value for oxygen-blown operation was estimated to be 3316 kJ/m{sup 3} for a commercial KRB transport gasifier. This heating value is about 80% of the minimum required for firing a gas turbine. Removing 50% of the carbon dioxide from the syngas would increase the heating value to 4583 kJ/m{sup 3}, i.e., to about 110% of the minimum requirement, and 95% removal would provide a heating value of 7080 kJ/m{sup 3}. Supplemental firing of natural gas would also allow the integrated gasification combined cycle (IGCC) technology to be utilized without having to remove CO{sub 2}. If removal of all nitrogen from the input gas streams such as the coal transport air were

  8. JV Task - 129 Advanced Conversion Test - Bulgarian Lignite

    Energy Technology Data Exchange (ETDEWEB)

    Michael Swanson; Everett Sondreal; Daniel Laudal; Douglas Hajicek; Ann Henderson; Brandon Pavlish

    2009-03-27

    The objectives of this Energy & Environmental Research Center (EERC) project were to evaluate Bulgarian lignite performance under both fluid-bed combustion and gasification conditions and provide a recommendation as to which technology would be the most technically feasible for the particular feedstock and also identify any potential operating issues (such as bed agglomeration, etc.) that may limit the applicability of a potential coal conversion technology. Gasification tests were run at the EERC in the 100-400-kg/hr transport reactor development unit (TRDU) on a 50-tonne sample of lignite supplied by the Bulgarian Lignite Power Project. The quality of the test sample was inferior to any coal previously tested in this unit, containing 50% ash at 26.7% moisture and having a higher heating value of 5043 kJ/kg after partial drying in preparation for testing. The tentative conclusion reached on the basis of tests in the TRDU is that oxygen-blown gasification of this high-ash Bulgarian lignite sample using the Kellogg, Brown, and Root (KBR) transport gasifier technology would not provide a syngas suitable for directly firing a gas turbine. After correcting for test conditions specific to the pilot-scale TRDU, including an unavoidably high heat loss and nitrogen dilution by transport air, the best-case heating value for oxygen-blown operation was estimated to be 3316 kJ/m{sup 3} for a commercial KRB transport gasifier. This heating value is about 80% of the minimum required for firing a gas turbine. Removing 50% of the carbon dioxide from the syngas would increase the heating value to 4583 kJ/m{sup 3}, i.e., to about 110% of the minimum requirement, and 95% removal would provide a heating value of 7080 kJ/m{sup 3}. Supplemental firing of natural gas would also allow the integrated gasification combined cycle (IGCC) technology to be utilized without having to remove CO{sub 2}. If removal of all nitrogen from the input gas streams such as the coal transport air were

  9. Targeting the ATR-CHK1 Axis in Cancer Therapy

    Directory of Open Access Journals (Sweden)

    Stuart Rundle

    2017-04-01

    Full Text Available Targeting the DNA damage response (DDR is a new therapeutic approach in cancer that shows great promise for tumour selectivity. Key components of the DDR are the ataxia telangiectasia mutated and Rad3 related (ATR and checkpoint kinase 1 (CHK1 kinases. This review article describes the role of ATR and its major downstream target, CHK1, in the DDR and why cancer cells are particularly reliant on the ATR-CHK1 pathway, providing the rationale for targeting these kinases, and validation of this hypothesis by genetic manipulation. The recent development of specific inhibitors and preclinical data using these inhibitors not only as chemosensitisers and radiosensitisers but also as single agents to exploit specific pathologies of tumour cells is described. These potent and specific inhibitors have now entered clinical trial and early results are presented.

  10. Targeting the ATR-CHK1 Axis in Cancer Therapy

    Science.gov (United States)

    Rundle, Stuart; Bradbury, Alice; Drew, Yvette; Curtin, Nicola J.

    2017-01-01

    Targeting the DNA damage response (DDR) is a new therapeutic approach in cancer that shows great promise for tumour selectivity. Key components of the DDR are the ataxia telangiectasia mutated and Rad3 related (ATR) and checkpoint kinase 1 (CHK1) kinases. This review article describes the role of ATR and its major downstream target, CHK1, in the DDR and why cancer cells are particularly reliant on the ATR-CHK1 pathway, providing the rationale for targeting these kinases, and validation of this hypothesis by genetic manipulation. The recent development of specific inhibitors and preclinical data using these inhibitors not only as chemosensitisers and radiosensitisers but also as single agents to exploit specific pathologies of tumour cells is described. These potent and specific inhibitors have now entered clinical trial and early results are presented. PMID:28448462

  11. Homeostatic regulation of meiotic DSB formation by ATM/ATR

    Energy Technology Data Exchange (ETDEWEB)

    Cooper, Tim J.; Wardell, Kayleigh; Garcia, Valerie; Neale, Matthew J., E-mail: m.neale@sussex.ac.uk

    2014-11-15

    Ataxia–telangiectasia mutated (ATM) and RAD3-related (ATR) are widely known as being central players in the mitotic DNA damage response (DDR), mounting responses to DNA double-strand breaks (DSBs) and single-stranded DNA (ssDNA) respectively. The DDR signalling cascade couples cell cycle control to damage-sensing and repair processes in order to prevent untimely cell cycle progression while damage still persists [1]. Both ATM/ATR are, however, also emerging as essential factors in the process of meiosis; a specialised cell cycle programme responsible for the formation of haploid gametes via two sequential nuclear divisions. Central to achieving accurate meiotic chromosome segregation is the introduction of numerous DSBs spread across the genome by the evolutionarily conserved enzyme, Spo11. This review seeks to explore and address how cells utilise ATM/ATR pathways to regulate Spo11-DSB formation, establish DSB homeostasis and ensure meiosis is completed unperturbed.

  12. Homeostatic regulation of meiotic DSB formation by ATM/ATR.

    Science.gov (United States)

    Cooper, Tim J; Wardell, Kayleigh; Garcia, Valerie; Neale, Matthew J

    2014-11-15

    Ataxia-telangiectasia mutated (ATM) and RAD3-related (ATR) are widely known as being central players in the mitotic DNA damage response (DDR), mounting responses to DNA double-strand breaks (DSBs) and single-stranded DNA (ssDNA) respectively. The DDR signalling cascade couples cell cycle control to damage-sensing and repair processes in order to prevent untimely cell cycle progression while damage still persists [1]. Both ATM/ATR are, however, also emerging as essential factors in the process of meiosis; a specialised cell cycle programme responsible for the formation of haploid gametes via two sequential nuclear divisions. Central to achieving accurate meiotic chromosome segregation is the introduction of numerous DSBs spread across the genome by the evolutionarily conserved enzyme, Spo11. This review seeks to explore and address how cells utilise ATM/ATR pathways to regulate Spo11-DSB formation, establish DSB homeostasis and ensure meiosis is completed unperturbed.

  13. The orally active and bioavailable ATR kinase inhibitor AZD6738 potentiates the anti-tumor effects of cisplatin to resolve ATM-deficient non-small cell lung cancer in vivo.

    Science.gov (United States)

    Vendetti, Frank P; Lau, Alan; Schamus, Sandra; Conrads, Thomas P; O'Connor, Mark J; Bakkenist, Christopher J

    2015-12-29

    ATR and ATM are DNA damage signaling kinases that phosphorylate several thousand substrates. ATR kinase activity is increased at damaged replication forks and resected DNA double-strand breaks (DSBs). ATM kinase activity is increased at DSBs. ATM has been widely studied since ataxia telangiectasia individuals who express no ATM protein are the most radiosensitive patients identified. Since ATM is not an essential protein, it is widely believed that ATM kinase inhibitors will be well-tolerated in the clinic. ATR has been widely studied, but advances have been complicated by the finding that ATR is an essential protein and it is widely believed that ATR kinase inhibitors will be toxic in the clinic. We describe AZD6738, an orally active and bioavailable ATR kinase inhibitor. AZD6738 induces cell death and senescence in non-small cell lung cancer (NSCLC) cell lines. AZD6738 potentiates the cytotoxicity of cisplatin and gemcitabine in NSCLC cell lines with intact ATM kinase signaling, and potently synergizes with cisplatin in ATM-deficient NSCLC cells. In contrast to expectations, daily administration of AZD6738 and ATR kinase inhibition for 14 consecutive days is tolerated in mice and enhances the therapeutic efficacy of cisplatin in xenograft models. Remarkably, the combination of cisplatin and AZD6738 resolves ATM-deficient lung cancer xenografts.

  14. Test Driven Development: Advancing Knowledge by Conjecture and Confirmation

    Directory of Open Access Journals (Sweden)

    Manfred Lange

    2011-12-01

    Full Text Available Test Driven Development (TDD is a critical agile software development practice that supports innovation in short development cycles. However, TDD is one of the most challenging agile practices to adopt because it requires changes to work practices and skill sets. It is therefore important to gain an understanding of TDD through the experiences of those who have successfully adopted this practice. We collaborated with an agile team to provide this experience report on their adoption of TDD, using observations and interviews within the product development environment. This article highlights a number of practices that underlie successful development with TDD. To provide a theoretical perspective that can help to explain how TDD supports a positive philosophy of software development, we have revised Northover et al.’s conceptual framework, which is based on a four stage model of agile development, to reinterpret Popper’s theory of conjecture and falsification in the context of agile testing strategies. As a result of our findings, we propose an analytical model for TDD in agile software development which provides a theoretical basis for further investigations into the role of TDD and related practices.

  15. ATR National Scientific User Facility 2013 Annual Report

    Energy Technology Data Exchange (ETDEWEB)

    Ulrich, Julie A. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Robertson, Sarah [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2015-03-01

    This is the 2013 Annual Report for the Advanced Test Reactor National Scientific User Facility. This report includes information on university-run research projects along with a description of the program and the capabilities offered researchers.

  16. Advanced ThioClear process testing. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Lani, B.

    1998-03-01

    Wet scrubbing is the leading proven commercial post-combustion FGD technology available to meet the sulfur dioxide reductions required by the Clean Air Act Amendments. To reduce costs associated with wet FGD, Dravo Lime Company has developed the ThioClear process. ThioClear is an ex-situ forced oxidation magnesium-enhanced lime FGD process. ThioClear process differs from the conventional magnesium-enhanced lime process in that the recycle liquor has minimal suspended solids and the by-products are wallboard quality gypsum and magnesium hydroxide, an excellent reagent for water treatment. The process has demonstrated sulfur dioxide removal efficiencies of +95% in both a vertical spray scrubber tower and a horizontal absorber operating at gas velocities of 16 fps, respectively. This report details the optimization studies and associated economics from testing conducted at Dravo Lime Company`s pilot plant located at the Miami Fort Station of the Cincinnati Gas and Electric Company.

  17. ESCRIME: testing bench for advanced operator workstations in future plants

    Energy Technology Data Exchange (ETDEWEB)

    Poujol, A.; Papin, B. [CEA Centre d`Etudes Nucleaires de Cadarache, 13 - Saint-Paul-lez-Durance (France)

    1994-12-31

    The problem of optimal task allocation between man and computer for the operation of nuclear power plants is of major concern for the design of future plants. As the increased level of automation induces the modification of the tasks actually devoted to the operator in the control room, it is very important to anticipate these consequences at the plant design stage. The improvement of man machine cooperation is expected to play a major role in minimizing the impact of human errors on plant safety. The CEA has launched a research program concerning the evolution of the plant operation in order to optimize the efficiency of the human/computer systems for a better safety. The objective of this program is to evaluate different modalities of man-machine share of tasks, in a representative context. It relies strongly upon the development of a specific testing facility, the ESCRIME work bench, which is presented in this paper. It consists of an EDF 1300MWe PWR plant simulator connected to an operator workstation. The plant simulator model presents at a significant level of details the instrumentation and control of the plant and the main connected circuits. The operator interface is based on the generalization of the use of interactive graphic displays, and is intended to be consistent to the tasks to be performed by the operator. The functional architecture of the workstation is modular, so that different cooperation mechanisms can be implemented within the same framework. It is based on a thorough analysis and structuration of plant control tasks, in normal as well as in accident situations. The software architecture design follows the distributed artificial intelligence approach. Cognitive agents cooperate in order to operate the process. The paper presents the basic principles and the functional architecture of the test bed and describes the steps and the present status of the program. (author).

  18. Advanced ion beam calorimetry for the test facility ELISE

    Science.gov (United States)

    Nocentini, R.; Bonomo, F.; Pimazzoni, A.; Fantz, U.; Franzen, P.; Fröschle, M.; Heinemann, B.; Pasqualotto, R.; Riedl, R.; Ruf, B.; Wünderlich, D.

    2015-04-01

    The negative ion source test facility ELISE (Extraction from a Large Ion Source Experiment) is in operation since beginning of 2013 at the Max-Planck-Institut für Plasmaphysik (IPP) in Garching bei München. The large radio frequency driven ion source of ELISE is about 1×1 m2 in size (1/2 the ITER source) and can produce a plasma for up to 1 h. Negative ions can be extracted and accelerated by an ITER-like extraction system made of 3 grids with an area of 0.1 m2, for 10 s every 3 minutes. A total accelerating voltage of up to 60 kV is available, i.e. a maximum ion beam power of about 1.2 MW can be produced. ELISE is equipped with several beam diagnostic tools for the evaluation of the beam characteristics. In order to evaluate the beam properties with a high level of detail, a sophisticated diagnostic calorimeter has been installed in the test facility at the end of 2013, starting operation in January 2014. The diagnostic calorimeter is split into 4 copper plates with separate water calorimetry for each of the plates. Each calorimeter plate is made of 15×15 copper blocks, which act as many separate inertial calorimeters and are attached to a copper plate with an embedded cooling circuit. The block geometry and the connection with the cooling plate are optimized to accurately measure the time-averaged power of the 10 s ion beam. The surface of the blocks is covered with a black coating that allows infrared (IR) thermography which provides a 2D profile of the beam power density. In order to calibrate the IR thermography, 48 thermocouples are installed in as many blocks, arranged in two vertical and two horizontal rows. The paper describes the beam calorimetry in ELISE, including the methods used for the IR thermography, the water calorimetry and the analytical methods for beam profile evaluation. It is shown how the maximum beam inhomogeneity amounts to 13% in average. The beam divergence derived by IR thermography ranges between 1° and 4° and correlates

  19. Rapid determination of baicalin and total baicalein content in Scutellariae radix by ATR-IR and NIR spectroscopy.

    Science.gov (United States)

    Navarro Escamilla, M; Rodenas Sanz, F; Li, H; Schönbichler, S A; Yang, B; Bonn, G K; Huck, C W

    2013-09-30

    In this study methods for the quantification of baicalin and total baicalein in Scutellariae radix with near infrared (NIR) spectroscopy and attenuated-total-reflectance mid-infrared (ATR-IR) spectroscopy in hyphenation with multivariate analysis were developed and compared. The reference analysis was performed by high performance liquid chromatography coupled to diode array detection (HPLC-DAD). Different pretreatments like standard normal variate (SNV), multiplicative scatter correction (MSC), first and second derivative Savitzky-Golay were applied on the spectra to optimize the calibrations. A principal component analysis was performed with both spectroscopic methods to distinguish wild and cultivated samples. Quality parameters obtained for test-set calibration models of ATR-IR spectroscopy (baicalin: standard error of prediction (SEP)=1.31, ratio performance to deviation (RPD)=2.91 and R(2)=0.88; total baicalein: SEP=1.02, RPD=3.24 and R(2)=0.89) and NIR spectroscopy (baicalin: SEP=1.50, RPD=2.54 and R(2)=0.88; total baicalein: SEP=1.19, RPD=2.76 and R(2)=0.84) demonstrate that both spectroscopic techniques in combination with multivariate analysis are successful tools for the quantification of baicalin and total baicalein in Scutellariae radix, but it was found that ATR-IR spectroscopy provides higher accuracy in the given application. Furthermore it was proved that wild and cultivated samples can be distinguished by ATR-IR.

  20. Cone penetrometer acceptance test report

    Energy Technology Data Exchange (ETDEWEB)

    Boechler, G.N.

    1996-09-19

    This Acceptance Test Report (ATR) documents the results of acceptance test procedure WHC-SD-WM-ATR-151. Included in this report is a summary of the tests, the results and issues, the signature and sign- off ATP pages, and a summarized table of the specification vs. ATP section that satisfied the specification.

  1. Advanced Accelerated Power Cycling Test for Reliability Investigation of Power Device Modules

    DEFF Research Database (Denmark)

    Choi, Uimin; Jørgensen, Søren; Blaabjerg, Frede

    2016-01-01

    of tested power IGBT module. The various realistic electrical operating conditions close to real three-phase converter applications can be achieved by the simple control method. Further, by the proposed concept of applying the temperature stress, it is possible to apply various magnitudes of temperature......This paper presents an apparatus and methodology for an advanced accelerated power cycling test of insulated-gate bipolar transistor (IGBT) modules. In this test, the accelerated power cycling test can be performed under more realistic electrical operating conditions with online wear-out monitoring...... power cycling test setup is given. Then, an improved in situ junction temperature estimation method using on-state collector–emitter voltage VCE ON and load current is proposed. In addition, a procedure of advanced accelerated power cycling test and test results with 600 V, 30 A transfer molded IGBT...

  2. CANDU RU fuel manufacturing basic technology development and advanced fuel verification tests

    Energy Technology Data Exchange (ETDEWEB)

    Chung, Chang Hwan; Chang, S.K.; Hong, S.D. [and others

    1999-04-01

    A PHWR advanced fuel named the CANFLEX fuel has been developed through a KAERI/AECL joint Program. The KAERI made fuel bundle was tested at the KAERI Hot Test Loop for the performance verification of the bundle design. The major test activities were the fuel bundle cross-flow test, the endurance fretting/vibration test, the freon CHF test, and the fuel bundle heat-up test. KAERI also has developing a more advanced PHWR fuel, the CANFLEX-RU fuel, using recovered uranium to extend fuel burn-up in the CANDU reactors. For the purpose of proving safety of the RU handling techniques and appraising feasibility of the CANFLEX-RU fuel fabrication in near future, a physical, chemical and radiological characterization of the RU powder and pellets was performed. (author). 54 refs., 46 tabs., 62 figs.

  3. Recovery of Information from the Fast Flux Test Facility for the Advanced Fuel Cycle Initiative

    Energy Technology Data Exchange (ETDEWEB)

    Nielsen, Deborah L.; Makenas, Bruce J.; Wootan, David W.; Butner, R. Scott; Omberg, Ronald P.

    2009-09-30

    The Fast Flux Test Facility is the most recent Liquid Metal Reactor to operate in the United States. Information from the design, construction, and operation of this reactor was at risk as the facilities associated with the reactor are being shut down. The Advanced Fuel Cycle Initiative is a program managed by the Office of Nuclear Energy of the U.S. Department of Energy with a mission to develop new fuel cycle technologies to support both current and advanced reactors. Securing and preserving the knowledge gained from operation and testing in the Fast Flux Test Facility is an important part of the Knowledge Preservation activity in this program.

  4. Interior noise control ground test studies for advanced turboprop aircraft applications

    Science.gov (United States)

    Simpson, Myles A.; Cannon, Mark R.; Burge, Paul L.; Boyd, Robert P.

    1989-01-01

    The measurement and analysis procedures are documented, and the results of interior noise control ground tests conducted on a DC-9 aircraft test section are summarized. The objectives of these tests were to study the fuselage response characteristics of treated and untreated aircraft with aft-mount advanced turboprop engines and to analyze the effectiveness of selected noise control treatments in reducing passenger cabin noise on these aircraft. The results of fuselage structural mode surveys, cabin cavity surveys and sound intensity surveys are presented. The performance of various structural and cabin sidewall treatments is assessed, based on measurements of the resulting interior noise levels under simulated advanced turboprop excitation.

  5. Test methodology for elemental sulfur resistant advanced materials for oil and gas field equipment

    Energy Technology Data Exchange (ETDEWEB)

    Steinbeck, G. [Verein Deutscher Eisenhuettenleute, Duesseldorf (Germany); Bruckhoff, W. [BEB Erdgas und Erdoel GmbH, Hannover (Germany); Koehler, M. [Krupp-VDM AG, Werdohl (Germany); Schlerkmann, H. [Mannesmann Forschungsinstitut, Duisburg (Germany); Schmitt, G. [Iserlohn Polytechnic (Germany). Lab. for Corrosion Protection

    1995-10-01

    The great variety of methodologies for testing the performance of advanced materials for resistance to elemental sulfur in oil and gas industry prompted the Technical Committee for Corrosion of the German Iron and Steel Institute (VDEh) to define recommended test procedures. These procedures have already found wide acceptance in the German materials and oil and gas industry.

  6. Reactor Physics Methods and Preconceptual Core Design Analyses for Conversion of the Advanced Test Reactor to Low-Enriched Uranium Fuel Annual Report for Fiscal Year 2012

    Energy Technology Data Exchange (ETDEWEB)

    David W. Nigg; Sean R. Morrell

    2012-09-01

    Under the current long-term DOE policy and planning scenario, both the ATR and the ATRC will be reconfigured at an appropriate time within the next several years to operate with low-enriched uranium (LEU) fuel. This will be accomplished under the auspices of the Reduced Enrichment Research and Test Reactor (RERTR) Program, administered by the DOE National Nuclear Security Administration (NNSA). At a minimum, the internal design and composition of the fuel element plates and support structure will change, to accommodate the need for low enrichment in a manner that maintains total core excess reactivity at a suitable level for anticipated operational needs throughout each cycle while respecting all control and shutdown margin requirements and power distribution limits. The complete engineering design and optimization of LEU cores for the ATR and the ATRC will require significant multi-year efforts in the areas of fuel design, development and testing, as well as a complete re-analysis of the relevant reactor physics parameters for a core composed of LEU fuel, with possible control system modifications. Ultimately, revalidation of the computational physics parameters per applicable national and international standards against data from experimental measurements for prototypes of the new ATR and ATRC core designs will also be required for Safety Analysis Report (SAR) changes to support routine operations with LEU. This report is focused on reactor physics analyses conducted during Fiscal Year (FY) 2012 to support the initial development of several potential preconceptual fuel element designs that are suitable candidates for further study and refinement during FY-2013 and beyond. In a separate, but related, effort in the general area of computational support for ATR operations, the Idaho National Laboratory (INL) is conducting a focused multiyear effort to introduce modern high-fidelity computational reactor physics software and associated validation protocols to replace

  7. HCLK2 is required for activity of the DNA damage response kinase ATR

    DEFF Research Database (Denmark)

    Rendtlew Danielsen, Jannie M; Larsen, Dorthe Helena; Schou, Kenneth Bødtker

    2008-01-01

    ATR is a protein kinase that orchestrates the cellular response to replication problems and DNA damage. HCLK2 has previously been reported to stabilize ATR and Chk1. Here we provide evidence that human HCLK2 acts at an early step in the ATR signaling pathway and contributes to full-scale activati...

  8. Classification methods for noise transients in advanced gravitational-wave detectors II: performance tests on Advanced LIGO data

    CERN Document Server

    Powell, Jade; Lynch, Ryan; Trifirò, Daniele; Cuoco, Elena; Cavaglià, Marco; Heng, Ik Siong; Font, José A

    2016-01-01

    The data taken by the advanced LIGO and Virgo gravitational-wave detectors contains short duration noise transients that limit the significance of astrophysical detections and reduce the duty cycle of the instruments. As the advanced detectors are reaching sensitivity levels that allow for multiple detections of astrophysical gravitational-wave sources it is crucial to achieve a fast and accurate characterization of non-astrophysical transient noise shortly after it occurs in the detectors. Previously we presented three methods for the classification of transient noise sources. They are Principal Component Analysis for Transients (PCAT), Principal Component LALInference Burst (PC-LIB) and Wavelet Detection Filter with Machine Learning (WDF-ML). In this study we carry out the first performance tests of these algorithms on gravitational-wave data from the Advanced LIGO detectors. We use the data taken between the 3rd of June 2015 and the 14th of June 2015 during the 7th engineering run (ER7), and outline the im...

  9. Status of advanced airfoil tests in the Langley 0.3-meter transonic cryogenic tunnel

    Science.gov (United States)

    Ladson, C. L.; Ray, E. J.

    1984-01-01

    A joint NASA/U.S. industry program to test advanced technology airfoils in the Langley 0.3-meter Transonic Tunnel (TCT) was formulated under the Langley ACEE Project Office. The objectives include providing U.S. industry an opportunity to compare their most advanced airfoils to the latest NASA designs by means of high Reynolds number tests in the same facility. At the same time, industry would again experience in the design and construction of cryogenic test techniques. The status and details of the test program are presented. Typical aerodynamic results obtained, to date, are presented at chord Reynolds number up to 45 x 10(6) and are compared to results from other facilities and theory. Details of a joint agreement between NASA and the Deutsche Forschungs- und Versuchsantalt fur Luft- and Raumfahrt e.V. (DFVLR) for tests of two airfoils are also included. Results of these tests will be made available as soon as practical.

  10. Comparison between ATR-IR, Raman, concatenated ATR-IR and Raman spectroscopy for the determination of total antioxidant capacity and total phenolic content of Chinese rice wine.

    Science.gov (United States)

    Wu, Zhengzong; Xu, Enbo; Long, Jie; Pan, Xiaowei; Xu, Xueming; Jin, Zhengyu; Jiao, Aiquan

    2016-03-01

    The application of attenuated total reflectance infrared spectroscopy (ATR-IR), Raman spectroscopy (RS) and combination of ATR-IR and RS for measurements of total antioxidant capacity (TAC) and total phenolic content (TPC) of Chinese rice wine (CRW) were investigated in this study. Synergy interval partial least-squares (SiPLS), support vector machine (SVM) and principal component analysis (PCA) were applied to process the merged data from two individual instruments. It was observed that the performances of models based on the RS spectra were better than those based on the ATR-IR spectra. In addition, SVM models based on the efficient information extracted from ATR-IR and RS spectra were superior to PLS models based on the same information and PLS models based on ATR-IR or RS spectra. The overall results demonstrated that integrating ATR-IR and RS was possible and could improve the prediction accuracy of TAC and TPC in CRWs.

  11. General Aviation Flight Test of Advanced Operations Enabled by Synthetic Vision

    Science.gov (United States)

    Glaab, Louis J.; Hughhes, Monica F.; Parrish, Russell V.; Takallu, Mohammad A.

    2014-01-01

    A flight test was performed to compare the use of three advanced primary flight and navigation display concepts to a baseline, round-dial concept to assess the potential for advanced operations. The displays were evaluated during visual and instrument approach procedures including an advanced instrument approach resembling a visual airport traffic pattern. Nineteen pilots from three pilot groups, reflecting the diverse piloting skills of the General Aviation pilot population, served as evaluation subjects. The experiment had two thrusts: 1) an examination of the capabilities of low-time (i.e., <400 hours), non-instrument-rated pilots to perform nominal instrument approaches, and 2) an exploration of potential advanced Visual Meteorological Conditions (VMC)-like approaches in Instrument Meteorological Conditions (IMC). Within this context, advanced display concepts are considered to include integrated navigation and primary flight displays with either aircraft attitude flight directors or Highway In The Sky (HITS) guidance with and without a synthetic depiction of the external visuals (i.e., synthetic vision). Relative to the first thrust, the results indicate that using an advanced display concept, as tested herein, low-time, non-instrument-rated pilots can exhibit flight-technical performance, subjective workload and situation awareness ratings as good as or better than high-time Instrument Flight Rules (IFR)-rated pilots using Baseline Round Dials for a nominal IMC approach. For the second thrust, the results indicate advanced VMC-like approaches are feasible in IMC, for all pilot groups tested for only the Synthetic Vision System (SVS) advanced display concept.

  12. U.S. Department of Energy -- Advanced Vehicle Testing Activity: Plug-in Hybrid Electric Vehicle Testing and Demonstration Activities

    Energy Technology Data Exchange (ETDEWEB)

    James E. Francfort; Donald Karner; John G. Smart

    2009-05-01

    The U.S. Department of Energy’s (DOE) Advanced Vehicle Testing Activity (AVTA) tests plug-in hybrid electric vehicles (PHEV) in closed track, dynamometer and onroad testing environments. The onroad testing includes the use of dedicated drivers on repeated urban and highway driving cycles that range from 10 to 200 miles, with recharging between each loop. Fleet demonstrations with onboard data collectors are also ongoing with PHEVs operating in several dozen states and Canadian Provinces, during which trips- and miles-per-charge, charging demand and energy profiles, and miles-per-gallon and miles-per-kilowatt-hour fuel use results are all documented, allowing an understanding of fuel use when vehicles are operated in charge depleting, charge sustaining, and mixed charge modes. The intent of the PHEV testing includes documenting the petroleum reduction potential of the PHEV concept, the infrastructure requirements, and operator recharging influences and profiles. As of May 2008, the AVTA has conducted track and dynamometer testing on six PHEV conversion models and fleet testing on 70 PHEVs representing nine PHEV conversion models. A total of 150 PHEVs will be in fleet testing by the end of 2008, all with onboard data loggers. The onroad testing to date has demonstrated 100+ miles per gallon results in mostly urban applications for approximately the first 40 miles of PHEV operations. The primary goal of the AVTA is to provide advanced technology vehicle performance benchmark data for technology modelers, research and development programs, and technology goal setters. The AVTA testing results also assist fleet managers in making informed vehicle purchase, deployment and operating decisions. The AVTA is part of DOE’s Vehicle Technologies Program. These AVTA testing activities are conducted by the Idaho National Laboratory and Electric Transportation Engineering Corporation, with Argonne National Laboratory providing dynamometer testing support. The proposed paper

  13. Integrate knowledge acquisition with target recognition through closed-loop ATR

    Science.gov (United States)

    Yu, Ssu-Hsin; McLaughlin, Pat; Zatezalo, Aleksandar; Hsiao, Kai-yuh; Boskovic, Jovan

    2015-05-01

    Automatic Target Recognition (ATR) algorithm performance is highly dependent on the sensing conditions under which the input data is collected. Open-loop fly-bys often produce poor results due to less than ideal measurement conditions. In addition, ATR algorithms must be extremely complicated to handle the diverse range of inputs with a resulting reduction in overall performance and increase in complexity. Our approach, closed-loop ATR (CL-ATR), focuses on improving the quality of information input to the ATR algorithms by optimizing motion, sensor settings and team (vehicle-vehicle-human) collaboration to dramatically improve classification accuracy. By managing the data collection guided by predicted ATR performance gain, we increase the information content of the data and thus dramatically improve ATR performance with existing ATR algorithms. CL-ATR has two major functions; first, an ATR utility function, which represents the performance sensitivity of ATR produced classification labels as a function of parameters that correlate to vehicle/sensor states. This utility function is developed off-line and is often available from the original ATR study as a confusion matrix, or it can be derived through simulation without direct access to the inner working of the ATR algorithm. The utility function is inserted into our CLATR framework to autonomously control the vehicle/sensor. Second, an on-board planner maps the utility function into vehicle position and sensor collection plans. Because we only require the utility function on-board, we can activate any ATR algorithm onto a unmanned aerial vehicle (UAV) platform no matter how complex. This pairing of ATR performance profiles with vehicle/sensor controls creates a unique and powerful active perception behavior.

  14. Refinements and Tests of an Advanced Controller to Mitigate Fatigue Loads in the Controls Advanced Research Turbine: Preprint

    Energy Technology Data Exchange (ETDEWEB)

    Wright, A.; Fleming, P.

    2010-12-01

    Wind turbines are complex, nonlinear, dynamic systems forced by aerodynamic, gravitational, centrifugal, and gyroscopic loads. The aerodynamics of wind turbines are nonlinear, unsteady, and complex. Turbine rotors are subjected to a complicated 3-D turbulent wind inflow field, with imbedded coherent vortices that drive fatigue loads and reduce lifetime. Design of control algorithms for wind turbines must account for multiple control objectives. Future large multi-megawatt turbines must be designed with lighter weight structures, using active controls to mitigate fatigue loads, while maximizing energy capture. Active damping should be added to these dynamic structures to maintain stability for operation in a complex environment. At the National Renewable Energy Laboratory (NREL), we have designed, implemented, and tested advanced controls to maximize energy extraction and reduce structural dynamic loads. These control designs are based on linear models of the turbine that are generated by specialized modeling software. In this paper, we present field test results of an advanced control algorithm to mitigate blade, tower, and drivetrain loads in Region 3.

  15. Advanced Guidance and Control Methods for Reusable Launch Vehicles: Test Results

    Science.gov (United States)

    Hanson, John M.; Jones, Robert E.; Krupp, Don R.; Fogle, Frank R. (Technical Monitor)

    2002-01-01

    There are a number of approaches to advanced guidance and control (AG&C) that have the potential for achieving the goals of significantly increasing reusable launch vehicle (RLV) safety/reliability and reducing the cost. In this paper, we examine some of these methods and compare the results. We briefly introduce the various methods under test, list the test cases used to demonstrate that the desired results are achieved, show an automated test scoring method that greatly reduces the evaluation effort required, and display results of the tests. Results are shown for the algorithms that have entered testing so far.

  16. Testing of Passive Safety System Performance for Higher Power Advanced Reactors

    Energy Technology Data Exchange (ETDEWEB)

    brian G. Woods; Jose Reyes, Jr.; John Woods; John Groome; Richard Wright

    2004-12-31

    This report describes the results of NERI research on the testing of advanced passive safety performance for the Westinghouse AP1000 design. The objectives of this research were: (a) to assess the AP1000 passive safety system core cooling performance under high decay power conditions for a spectrum of breaks located at a variety of locations, (b) to compare advanced thermal hydraulic computer code predictions to the APEX high decay power test data and (c) to develop new passive safety system concepts that could be used for Generation IV higher power reactors.

  17. Test Method Designed to Evaluate Cylinder Liner-Piston Ring Coatings for Advanced Heat Engines

    Science.gov (United States)

    Radil, Kevin C.

    1997-01-01

    Research on advanced heat engine concepts, such as the low-heat-rejection engine, have shown the potential for increased thermal efficiency, reduced emissions, lighter weight, simpler design, and longer life in comparison to current diesel engine designs. A major obstacle in the development of a functional advanced heat engine is overcoming the problems caused by the high combustion temperatures at the piston ring/cylinder liner interface, specifically at top ring reversal (TRR). Therefore, advanced cylinder liner and piston ring materials are needed that can survive under these extreme conditions. To address this need, researchers at the NASA Lewis Research Center have designed a tribological test method to help evaluate candidate piston ring and cylinder liner materials for advanced diesel engines.

  18. Standardization Efforts for Mechanical Testing and Design of Advanced Ceramic Materials and Components

    Science.gov (United States)

    Salem, Jonathan A.; Jenkins, Michael G.

    2003-01-01

    Advanced aerospace systems occasionally require the use of very brittle materials such as sapphire and ultra-high temperature ceramics. Although great progress has been made in the development of methods and standards for machining, testing and design of component from these materials, additional development and dissemination of standard practices is needed. ASTM Committee C28 on Advanced Ceramics and ISO TC 206 have taken a lead role in the standardization of testing for ceramics, and recent efforts and needs in standards development by Committee C28 on Advanced Ceramics will be summarized. In some cases, the engineers, etc. involved are unaware of the latest developments, and traditional approaches applicable to other material systems are applied. Two examples of flight hardware failures that might have been prevented via education and standardization will be presented.

  19. HMGA2 Inhibits Apoptosis through Interaction with ATR-CHK1 Signaling Complex in Human Cancer Cells

    Directory of Open Access Journals (Sweden)

    Suchitra Natarajan

    2013-03-01

    Full Text Available The non-histone chromatin binding protein high mobility group AT-hook 2 (HMGA2 is expressed in stem cells and many cancer cells, including tumor initiating cells, but not translated in normal human somatic cells. The presence of HMGA2 is correlated with advanced neoplastic disease and poor prognosis for patients. We had previously demonstrated a role of HMGA2 in DNA repair pathways. In the present study, we employed different human tumor cell models with endogenous and exogenous expression of HMGA2 and show that upon DNA damage, the presence of HMGA2 caused an increased and sustained phosphorylation of the ataxia telangiectasia and Rad3-related kinase (ATR and its downstream target checkpoint kinase 1 (CHK1. The presence of activated pCHK1Ser296 coincided with prolonged G2/M block and increased tumor cell survival, which was enhanced further in the presence of HMGA2. Our study, thus, identifies a novel relationship between the ATR-CHK1 DNA damage response pathway and HMGA2, which may support the DNA repair function of HMGA2 in cancer cells. Furthermore, our data provide a rationale for the use of inhibitors to ATR or CHK1 and HMGA2 in the treatment of HMGA2-positive human cancer cells.

  20. Cleaning-in-place of immunoaffinity resins monitored by in situ ATR-FTIR spectroscopy.

    Science.gov (United States)

    Boulet-Audet, Maxime; Byrne, Bernadette; Kazarian, Sergei G

    2015-09-01

    In the next 10 years, the pharmaceutical industry anticipates that revenue from biotherapeutics will overtake those generated from small drug molecules. Despite effectively treating a range of chronic and life-threatening diseases, the high cost of biotherapeutics limits their use. For biotherapeutic monoclonal antibodies (mAbs), an important production cost is the affinity resin used for protein capture. Cleaning-in-place (CIP) protocols aim to optimise the lifespan of the resin by slowing binding capacity decay. Binding assays can determine resin capacity from the mobile phase, but do not reveal the underlying causes of Protein A ligand degradation. The focus needs to be on the stationary phase to examine the effect of CIP on the resin. To directly determine both the local Protein A ligand concentration and conformation on two Protein A resins, we developed a method based on attenuated total reflection (ATR) Fourier transform infrared (FTIR) spectroscopy. ATR-FTIR spectroscopic imaging revealed that applying a carefully controlled load to agarose beads produces an even and reproducible contact with the internal reflection element. This allowed detection and quantification of the binding capacity of the stationary phase. ATR-FTIR spectroscopy also showed that Protein A proteolysis does not seem to occur under typical CIP conditions (below 1 M NaOH). However, our data revealed that concentrations of NaOH above 0.1 M cause significant changes in Protein A conformation. The addition of >0.4 M trehalose during CIP significantly reduced NaOH-induced ligand unfolding observed for one of the two Protein A resins tested. Such insights could help to optimise CIP protocols in order to extend resin lifetime and reduce mAb production costs.

  1. Advanced topics on rotor blade full-scale structural fatigue testing and requirements

    DEFF Research Database (Denmark)

    Berring, Peter; Fedorov, Vladimir; Belloni, Federico

    further developed since then. Structures in composite materials are generally difficult and time consuming to test for fatigue resistance. Therefore, several methods for testing of blades have been developed and exist today. Those methods are presented in [1]. This report deals with more advanced topics...... for fatigue testing of wind turbine blades. One challenge is how to fatigue test blades under realistic conditions. In order to study this topic a finite element based multibody formulation using the floating frame of reference approach is used to study fatigue loading under different external conditions...

  2. Remote Advanced Payload Test Rig (RAPTR) Portable Payload Test System for the International Space Station (ISS)

    Science.gov (United States)

    Calvert, John; Freas, George, II

    2017-01-01

    The RAPTR was developed to test ISS payloads for NASA. RAPTR is a simulation of the Command and Data Handling (C&DH) interfaces of the ISS (MIL-STD 1553B, Ethernet and TAXI) and is designed to facilitate rapid testing and deployment of payload experiments to the ISS. The ISS Program's goal is to reduce the amount of time it takes a payload developer to build, test and fly a payload, including payload software. The RAPTR meets this need with its user oriented, visually rich interface. Additionally, the Analog and Discrete (A&D) signals of the following payload types may be tested with RAPTR: (1) EXPRESS Sub Rack Payloads; (2) ELC payloads; (3) External Columbus payloads; (4) External Japanese Experiment Module (JEM) payloads. The automated payload configuration setup and payload data inspection infrastructure is found nowhere else in ISS payload test systems. Testing can be done with minimal human intervention and setup, as the RAPTR automatically monitors parameters in the data headers that are sent to, and come from the experiment under test.

  3. Test Rack Development for Extended Operation of Advanced Stirling Convertors at NASA Glenn Research Center

    Science.gov (United States)

    Dugala, Gina M.

    2010-01-01

    The U.S. Department of Energy, Lockheed Martin Space Systems Company, Sunpower Inc., and NASA Glenn Research Center (GRC) have been developing an Advanced Stirling Radioisotope Generator (ASRG) for use as a power system on space science missions. This generator will make use of free-piston Stirling convertors to achieve higher conversion efficiency than with currently available alternatives. One part of NASA GRC's support of ASRG development includes extended operation testing of Advanced Stirling Convertors (ASCs) developed by Sunpower Inc. and GRC. The ASC consists of a free-piston Stirling engine integrated with a linear alternator. NASA GRC has been building test facilities to support extended operation of the ASCs for several years. Operation of the convertors in the test facility provides convertor performance data over an extended period of time. One part of the test facility is the test rack, which provides a means for data collection, convertor control, and safe operation. Over the years, the test rack requirements have changed. The initial ASC test rack utilized an alternating-current (AC) bus for convertor control; the ASRG Engineering Unit (EU) test rack can operate with AC bus control or with an ASC Control Unit (ACU). A new test rack is being developed to support extended operation of the ASC-E2s with higher standards of documentation, component selection, and assembly practices. This paper discusses the differences among the ASC, ASRG EU, and ASC-E2 test racks.

  4. Advancing the Science of Developmental Neurotoxicity (DNT) Testing for Better Safety Evaluation

    DEFF Research Database (Denmark)

    Bal-Price, Anna; Coecke, Sandra; Costa, Lucio

    2012-01-01

    Bal-Price AK, Coecke S, Costa L, Crofton KM, Fritsche E, Goldberg A, Grandjean P, Lein PJ, Li A, Lucchini R, Mundy WR, Padilla S, Persico A, Seiler AEM, Kreysa J. Conference Report: Advancing the Science of Developmental Neurotoxicity (DNT) Testing for Better Safety Evaluation. Altex 2012: 29: 202-15....

  5. Cognitive Levels of Questions Used by Iranian EFL Teachers in Advanced Reading Comprehension Tests

    Science.gov (United States)

    Khorsand, Narjess

    2009-01-01

    This study examined the cognitive levels of questions used by Iranian EFL teachers in advanced reading comprehension tests. Twenty teachers participated in this study and generated 215 questions which were then categorized according to Bloom's taxonomy. This taxonomy consists of six major categories which starts from the simplest behavior to the…

  6. Advancing the Science of Developmental Neurotoxicity (DNT) Testing for Better Safety Evaluation

    DEFF Research Database (Denmark)

    Bal-Price, Anna; Coecke, Sandra; Costa, Lucio;

    2012-01-01

    Bal-Price AK, Coecke S, Costa L, Crofton KM, Fritsche E, Goldberg A, Grandjean P, Lein PJ, Li A, Lucchini R, Mundy WR, Padilla S, Persico A, Seiler AEM, Kreysa J. Conference Report: Advancing the Science of Developmental Neurotoxicity (DNT) Testing for Better Safety Evaluation. Altex 2012: 29: 20...

  7. ACT Test Performance by Advanced Placement Students in Memphis City Schools

    Science.gov (United States)

    Mo, Lun; Yang, Fang; Hu, Xiangen; Calaway, Florance; Nickey, John

    2011-01-01

    The authors investigated the extent to which taking specific types of Advanced Placement (AP) courses and the number of courses taken predicts the likelihood of passing subject benchmarks and earning a score of 19 on the composite score on the ACT test, and examined the role gender plays in the projection. They found evidence that taking an AP…

  8. 75 FR 53681 - Office of Elementary and Secondary Education Overview Information; Advanced Placement (AP) Test...

    Science.gov (United States)

    2010-09-01

    ... Office of Elementary and Secondary Education Overview Information; Advanced Placement (AP) Test Fee... Elementary and Secondary Education Act of 1965, as amended (ESEA), requires that grant funds provided under.... Thelma Mel ndez de Santa Ana, Assistant Secretary for Elementary and Secondary Education. BILLING...

  9. Remote Advanced Payload Test Rig (RAPTR) Portable Payload Test System for the International Space Station

    Science.gov (United States)

    De La Cruz, Melinda; Henderson, Steve

    2016-01-01

    The RAPTR was developed to test ISS payloads for NASA. RAPTR is a simulation of the Command and Data Handling (C&DH) interfaces of the ISS (MIL-STD1553B, Ethernet and TAXI) and is designed for rapid testing and deployment of payload experiments to the ISS. The ISS's goal is to reduce the amount of time it takes for a payload developer to build, test and fly a payload, including payload software. The RAPTR meets this need with its user oriented, visually rich interface.

  10. Construction and testing of advanced ceramic fabric radiator components to 1000 K

    Energy Technology Data Exchange (ETDEWEB)

    Antoniak, Z.I.; Bates, J.M.; Webb, B.J.

    1990-01-01

    For a number of years, the authors have been studying the application of advanced ceramic fabric materials to spacecraft heat rejection systems. Their studies indicated that significant mass and launch volume savings could be realized through such application, but concrete evidence to support this contention was lacking. Last year they presented preliminary test data that supported their claims (Antoniak and Webb 1989). Recent pressure, heat transfer, and wicking tests and analyses confirm the earlier results.

  11. Development of Advanced Thermal and Environmental Barrier Coatings Using a High-Heat-Flux Testing Approach

    Science.gov (United States)

    Zhu, Dongming; Miller, Robert A.

    2003-01-01

    The development of low conductivity, robust thermal and environmental barrier coatings requires advanced testing techniques that can accurately and effectively evaluate coating thermal conductivity and cyclic resistance at very high surface temperatures (up to 1700 C) under large thermal gradients. In this study, a laser high-heat-flux test approach is established for evaluating advanced low conductivity, high temperature capability thermal and environmental barrier coatings under the NASA Ultra Efficient Engine Technology (UEET) program. The test approach emphasizes the real-time monitoring and assessment of the coating thermal conductivity, which initially rises under the steady-state high temperature thermal gradient test due to coating sintering, and later drops under the cyclic thermal gradient test due to coating cracking/delamination. The coating system is then evaluated based on damage accumulation and failure after the combined steady-state and cyclic thermal gradient tests. The lattice and radiation thermal conductivity of advanced ceramic coatings can also be evaluated using laser heat-flux techniques. The external radiation resistance of the coating is assessed based on the measured specimen temperature response under a laser- heated intense radiation-flux source. The coating internal radiation contribution is investigated based on the measured apparent coating conductivity increases with the coating surface test temperature under large thermal gradient test conditions. Since an increased radiation contribution is observed at these very high surface test temperatures, by varying the laser heat-flux and coating average test temperature, the complex relation between the lattice and radiation conductivity as a function of surface and interface test temperature may be derived.

  12. Integrating visual learning within a model-based ATR system

    Science.gov (United States)

    Carlotto, Mark; Nebrich, Mark

    2017-05-01

    Automatic target recognition (ATR) systems, like human photo-interpreters, rely on a variety of visual information for detecting, classifying, and identifying manmade objects in aerial imagery. We describe the integration of a visual learning component into the Image Data Conditioner (IDC) for target/clutter and other visual classification tasks. The component is based on an implementation of a model of the visual cortex developed by Serre, Wolf, and Poggio. Visual learning in an ATR context requires the ability to recognize objects independent of location, scale, and rotation. Our method uses IDC to extract, rotate, and scale image chips at candidate target locations. A bootstrap learning method effectively extends the operation of the classifier beyond the training set and provides a measure of confidence. We show how the classifier can be used to learn other features that are difficult to compute from imagery such as target direction, and to assess the performance of the visual learning process itself.

  13. Neutronics analysis of the DHCE experiment in ATR-ITV

    Energy Technology Data Exchange (ETDEWEB)

    Gomes, I.C.; Smith, D.L.; Tsai, H. [Argonne National Lab., IL (United States)

    1997-08-01

    The preliminary analysis of the DHCE experiments in the ITV and ATR was performed and its was concluded that such a vehicle is suitable for this kind of experiment. It is recommended to place an extra filter material in the thermocouple sleeve (such as B-10), to improve the helium to dpa ratio profile during irradiation. Also, it was concluded that a preliminary estimation of period of time for replacement of the external filter would be around 5 dps`s.

  14. Preliminary Discrimination of Butter Adulteration by ATR-FTIR Spectroscopy

    Directory of Open Access Journals (Sweden)

    Lucian Cuibus

    2015-05-01

    Full Text Available The Attenuated Total Reflectance-Fourier Transform Infrared Spectroscopy (ATR-FTIR  was applied for the discrimination of butter samples adulterated with solid fraction of palm oil. For FTIR fingerprinting of butter samples, with or without controlled additions of palm oil as adulterant was firstly obtained, using a Shimatsu Prestige 21 Spectrophotometer, including a horizontal diamond ATR accessory with reflection in the MIR region (3873-690 cm-1.The spiked butter samples including 0 level and seven increasing concentrations of palm fats, up to 50% were fingerprinted and the calibration curve was obtained (n=19. In parallel, the validation was realized using different set of spiked butter samples ranging 1-44.4 % of palm fat (n=7. Finally, an independent set of commercial samples was analized (n=14.Partial least squares (PLS model was used for statistical data processing in accordance with standard method. The value of the correlation coefficient (R2= 0.977 between actual and predicted values was statistically significant (p<0.001, considering the superposition of  "actual vs predicted” curves. This combined FTIR-PLS evaluation revealed that 3 out of  samples of butter were suspected of adulteration with palm oil, presented values 14 ranging 4-12%.In conclusion, ATR-FTIR methodology may offer an rapid evaluation of  butter samples authenticity. The low value for detection limit (3%palm oil in butter and the low limit of quantification (9.8% palm oil in butter confirms that ATR-FTIR spectroscopy  is a sensitive method to identify the adulteration of butter with  palm oil.   

  15. PHF11 promotes DSB resection, ATR signaling, and HR

    Science.gov (United States)

    Gong, Yi; Handa, Naofumi; Kowalczykowski, Stephen C.; de Lange, Titia

    2017-01-01

    Resection of double-strand breaks (DSBs) plays a critical role in their detection and appropriate repair. The 3′ ssDNA protrusion formed through resection activates the ATR-dependent DNA damage response (DDR) and is required for DSB repair by homologous recombination (HR). Here we report that PHF11 (plant homeodomain finger 11) encodes a previously unknown DDR factor involved in 5′ end resection, ATR signaling, and HR. PHF11 was identified based on its association with deprotected telomeres and localized to sites of DNA damage in S phase. Depletion of PHF11 diminished the ATR signaling response to telomere dysfunction and genome-wide DNA damage, reduced end resection at sites of DNA damage, resulted in compromised HR and misrejoining of S-phase DSBs, and increased the sensitivity to DNA-damaging agents. PHF11 interacted with the ssDNA-binding protein RPA and was found in a complex with several nucleases, including the 5′ dsDNA exonuclease EXO1. Biochemical experiments demonstrated that PHF11 stimulates EXO1 by overcoming its inhibition by RPA, suggesting that PHF11 acts (in part) by promoting 5′ end resection at RPA-bound sites of DNA damage. These findings reveal a role for PHF11 in DSB resection, DNA damage signaling, and DSB repair. PMID:28115467

  16. PHF11 promotes DSB resection, ATR signaling, and HR.

    Science.gov (United States)

    Gong, Yi; Handa, Naofumi; Kowalczykowski, Stephen C; de Lange, Titia

    2017-01-01

    Resection of double-strand breaks (DSBs) plays a critical role in their detection and appropriate repair. The 3' ssDNA protrusion formed through resection activates the ATR-dependent DNA damage response (DDR) and is required for DSB repair by homologous recombination (HR). Here we report that PHF11 (plant homeodomain finger 11) encodes a previously unknown DDR factor involved in 5' end resection, ATR signaling, and HR. PHF11 was identified based on its association with deprotected telomeres and localized to sites of DNA damage in S phase. Depletion of PHF11 diminished the ATR signaling response to telomere dysfunction and genome-wide DNA damage, reduced end resection at sites of DNA damage, resulted in compromised HR and misrejoining of S-phase DSBs, and increased the sensitivity to DNA-damaging agents. PHF11 interacted with the ssDNA-binding protein RPA and was found in a complex with several nucleases, including the 5' dsDNA exonuclease EXO1. Biochemical experiments demonstrated that PHF11 stimulates EXO1 by overcoming its inhibition by RPA, suggesting that PHF11 acts (in part) by promoting 5' end resection at RPA-bound sites of DNA damage. These findings reveal a role for PHF11 in DSB resection, DNA damage signaling, and DSB repair.

  17. Point-of-care testing for sexually transmitted infections: recent advances and implications for disease control

    Science.gov (United States)

    Tucker, Joseph D.; Bien, Cedric H.; Peeling, Rosanna W.

    2013-01-01

    Purpose of review Sexually transmitted infections (STIs) remain a major global public health issue, with more than 448 million incident bacterial infections each year. We review recent advances in STI point-of-care (POC) testing and implications for STI prevention and control. Recent findings Accurate immunochromatographic assays to detect HIV, hepatitis C virus (HCV) and syphilis antibodies have made home or supervised self-testing possible. Several studies have demonstrated feasibility and excellent test characteristics for HIV, HCV and syphilis POC tests. Rapid oral HIV tests are now available for purchase at retail sites across the United States. Combined HIV and syphilis tests using a single finger prick blood sample are under evaluation. Summary Oral POC STI tests with comparable performance to blood-based POC tests are available for self-testing. POC tests can expand screening, improve syndromic management and reduce loss to follow up. POC STI tests have the potential to facilitate prompt treatment and partner services. POC STI tests create opportunities for new social and financial models of community-based testing services. Increasing equity and access to testing will create challenges in linkage to care, quality assurance, partner services and surveillance. These important developments warrant research to understand appropriate contexts for implementation. PMID:23242343

  18. Recent advances of annular centrifugal extractor for hot test of nuclear waste partitioning process

    Institute of Scientific and Technical Information of China (English)

    HeXiang-Ming; YanYu-Shun; 等

    1998-01-01

    Advances are being made in the design of the annular centrifugal extractor fornuclear fuel reprocessing extraction process studies.The extractors have been built and tested.Twelve stages of this extractor and 50 stages are used toimplement the TRPO process for the cleanup ofcommercial and defense nuclear waste liquids,respectively.Following advances are available:(1) simple way of assembly and disassembly between rotor part and housing part of extractor,ease of manipulator operation;(2)automatic sampling from housing of extractor in hot cell;(3) compact multi-stage housing system;(4) easy interstage link;(5) computer data acquisition and monitoring system of speed.

  19. Super long-term creep tests of advanced HP and IP rotor steels

    Energy Technology Data Exchange (ETDEWEB)

    Tchizhik, A.A. [The Polzunov Central Boiler and Turbine Institute, Department the Fatigue Life of Materials for Power Plans Equipment, St. Petersburg (Russian Federation)

    1998-12-31

    A creep model has been developed for predicting the long-term creep behavior, in excess of 200,000 h for advanced materials.The new creep theory is based on a continuum microdamage model and is used to calculate the fields of stress and strain and wedge and cavities damage in critical components of steam and gas turbines. The application of this new model increases the reliability and service life of modern turbines. The accuracy of the model to predict long - term creep behavior, creep ductility was verified using the data bank of super long-term creep tests of advanced materials. (orig.) 12 refs.

  20. Advanced Vehicle Testing Activity Cold Weather On-road Testing of the Chevrolet Volt

    Energy Technology Data Exchange (ETDEWEB)

    Smart, John [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2015-03-01

    This report details cold weather on-road testing of a Chevrolet Volt. It quantifies changes in efficiency and electric range as ambient temperature changes. It will be published to INL's AVTA website as an INL technical report and will be accessible to the general public.

  1. VEHIL: test facility for fault management testing of advanced driver assistance systems

    NARCIS (Netherlands)

    Gietelink, O.J.; Ploeg, J.; Schutter, B. de; Verhaegen, M.A.H.

    2003-01-01

    This paper presents the latest developments of the VEHIL facility, which aims to make the development process of intelligent vehicles safer, cheaper and more manageable. The main feature of VEHIL is that a complete intelligent vehicle can be tested in a hardware-in-the-loop simulation environment. T

  2. ATR pathway inhibition is synthetically lethal in cancer cells with ERCC1 deficiency

    Science.gov (United States)

    Mohni, Kareem N.; Kavanaugh, Gina M.; Cortez, David

    2014-01-01

    The DNA damage response kinase ATR and its effector kinase CHEK1 are required for cancer cells to survive oncogene-induced replication stress. ATR inhibitors exhibit synthetic lethal interactions with deficiencies in the DNA damage response enzymes ATM and XRCC1 and with overexpression of the cell cycle kinase Cyclin E. Here we report a systematic screen to identify synthetic lethal interactions with ATR-pathway targeted drugs, rationalized by their predicted therapeutic utility in the oncology clinic. We found that reduced function in the ATR pathway itself provided the strongest synthetic lethal interaction. In addition, we found that loss of the structure specific-endonuclease ERCC1-XPF (ERCC4) is synthetic lethal with ATR pathway inhibitors. ERCC1-deficient cells exhibited elevated levels of DNA damage, which was increased further by ATR inhibition. When treated with ATR or CHEK1 inhibitors, ERCC1-deficient cells arrested in S phase and failed to complete cell cycle transit even after drug removal. Notably, triple-negative breast cancer cells and non-small cell lung cancer cells depleted of ERCC1 exhibited increased sensitivity to ATR-pathway targeted drugs. Overall, we concluded that ATR pathway-targeted drugs may offer particular utility in cancers with reduced ATR pathway function or reduced levels of ERCC4 activity. PMID:24662920

  3. Advanced development of the spectrum sciences Model 5005-TF, single-event test fixture

    Energy Technology Data Exchange (ETDEWEB)

    Ackermann, M.R.; Browning, J.S. (Sandia National Labs., Albuquerque, NM (USA)); Hughlock, B.W. (Boeing Aerospace and Electronics Co., Seattle, WA (USA)); Lum, G.K. (Lockheed Missiles and Space Co., Sunnyvale, CA (USA)); Tsacoyeanes, W.C. (Draper (Charles Stark) Lab., Inc., Cambridge, MA (USA)); Weeks, M.D. (Spectrum Sciences, Inc., Santa Clara, CA (USA))

    1990-09-01

    This report summarizes the advanced development of the Spectrum Sciences Model 5005-TF, Single-Event Test Fixture. The Model 5005-TF uses a Californium-252 (Cf-252) fission-fragment source to test integrated circuits and other devices for the effects of single-event phenomena. Particle identification methods commonly used in high-energy physics research and nuclear engineering have been incorporated into the Model 5005-TF for estimating the particle charge, mass, and energy parameters. All single-event phenomena observed in a device under test (DUT) are correlated with an identified fission fragment, and its linear energy transfer (LET) and range in the semiconductor material of the DUT.

  4. HARP model rotor test at the DNW. [Hughes Advanced Rotor Program

    Science.gov (United States)

    Dawson, Seth; Jordan, David; Smith, Charles; Ekins, James; Silverthorn, Lou

    1989-01-01

    Data from a test of a dynamically scaled model of the Hughes Advanced Rotor Program (HARP) bearingless model main rotor and 369K tail rotor are reported. The history of the HARP program and its goals are reviewed, and the main and tail rotor models are described. The test facilities and instrumentation are described, and wind tunnel test data are presented on hover, forward flight performance, and blade-vortex interaction. Performance data, acoustic data, and dynamic data from near field/far field and shear layer studies are presented.

  5. Boeing Helicopters Advanced Rotorcraft Transmission (ART) Program summary of component tests

    Science.gov (United States)

    Lenski, Joseph W., Jr.; Valco, Mark J.

    1992-07-01

    The principal objectives of the ART program are briefly reviewed, and the results of advanced technology component tests are summarized. The tests discussed include noise reduction by active cancellation, hybrid bidirectional tapered roller bearings, improved bearing life theory and friction tests, transmission lube study with hybrid bearings, and precision near-net-shape forged spur gears. Attention is also given to the study of high profile contact ratio noninvolute tooth form spur gears, parallel axis gear noise study, and surface modified titanium accessory spur gears.

  6. The ABC transporter MgAtr4 is a virulence factor of Mycosphaerella graminicola that affects colonization of substomatal cavities in wheat leaves

    NARCIS (Netherlands)

    Stergiopoulos, I.; Zwiers, L.H.; Waard, de M.A.

    2003-01-01

    The role in virulence of the ATP-binding cassette (ABC) transporters MgAtr1, MgAtr2, MgAtr3, MgAtr4, and MgAtr5 from Mycosphaerella graminicola was analyzed by gene disruption or replacement on seedlings of the susceptible wheat cultivar Obelisk. Disruption strains of MgAtr1 and MgAtr2 and replaceme

  7. Baseline Fracture Toughness and CGR testing of alloys X-750 and XM-19 (EPRI Phase I)

    Energy Technology Data Exchange (ETDEWEB)

    J. H. Jackson; S. P. Teysseyre

    2012-02-01

    The Advanced Test Reactor National Scientific User Facility (ATR NSUF) and Electric Power Research Institute (EPRI) formed an agreement to test representative alloys used as reactor structural materials as a pilot program toward establishing guidelines for future ATR NSUF research programs. This report contains results from the portion of this program established as Phase I (of three phases) that entails baseline fracture toughness, stress corrosion cracking (SCC), and tensile testing of selected materials for comparison to similar tests conducted at GE Global Research. The intent of this Phase I research program is to determine baseline properties for the materials of interest prior to irradiation, and to ensure comparability between laboratories using similar testing techniques, prior to applying these techniques to the same materials after having been irradiated at the Advanced Test Reactor (ATR). The materials chosen for this research are the nickel based super alloy X-750, and nitrogen strengthened austenitic stainless steel XM-19. A spare core shroud upper support bracket of alloy X-750 was purchased by EPRI from Southern Co. and a section of XM-19 plate was purchased by EPRI from GE-Hitachi. These materials were sectioned at GE Global Research and provided to INL.

  8. Baseline Fracture Toughness and CGR testing of alloys X-750 and XM-19 (EPRI Phase I)

    Energy Technology Data Exchange (ETDEWEB)

    J. H. Jackson; S. P. Teysseyre

    2012-10-01

    The Advanced Test Reactor National Scientific User Facility (ATR NSUF) and Electric Power Research Institute (EPRI) formed an agreement to test representative alloys used as reactor structural materials as a pilot program toward establishing guidelines for future ATR NSUF research programs. This report contains results from the portion of this program established as Phase I (of three phases) that entails baseline fracture toughness, stress corrosion cracking (SCC), and tensile testing of selected materials for comparison to similar tests conducted at GE Global Research. The intent of this Phase I research program is to determine baseline properties for the materials of interest prior to irradiation, and to ensure comparability between laboratories using similar testing techniques, prior to applying these techniques to the same materials after having been irradiated at the Advanced Test Reactor (ATR). The materials chosen for this research are the nickel based super alloy X-750, and nitrogen strengthened austenitic stainless steel XM-19. A spare core shroud upper support bracket of alloy X-750 was purchased by EPRI from Southern Co. and a section of XM-19 plate was purchased by EPRI from GE-Hitachi. These materials were sectioned at GE Global Research and provided to INL.

  9. FTIR/ATR study of protein adsorption and brushite transformation to hydroxyapatite.

    Science.gov (United States)

    Xie, Jing; Riley, Clyde; Kumar, Mukesh; Chittur, Krishnan

    2002-09-01

    Previous study has demonstrated that brushite (CaHPO4 x 2H2O), modified by partial potassium substitution for calcium, can transform quickly into hydroxyapatite (HA, Ca5(PO4)3OH) when exposed to aqueous salt solutions at room temperature. Analyses techniques used in those studies required sample retrieval from solution, which may alter the sample surface. In this work FTIR/ ATR was used in analysis, enabling in situ study of the transformation within the aqueous environment. To test the biocompatibility of this brushite, cellular response to the transformation needs to be understood. Cellular response was initiated by bovine serum albumin adsorption on the brushite surface. The response was studied by monitoring the conformation of the adsorbed protein, which is critical to cellular reaction. This required monitoring the brushite transformation and surface adsorbed protein conformation simultaneously which can be realized using FTIR/ATR. Based on band fitting and second derivative results from the spectra it was found that the conformation of the adsorbed BSA changes during the brushite transformation to HA. This study also demonstrated that the deposition of the brushite could be monitored in real time which offers the possibility for studying surface bonding during electrodeposition.

  10. Prediction of mixed hardwood lignin and carbohydrate content using ATR-FTIR and FT-NIR.

    Science.gov (United States)

    Zhou, Chengfeng; Jiang, Wei; Via, Brian K; Fasina, Oladiran; Han, Guangting

    2015-05-05

    This study used Attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy and Fourier transform near-infrared (FT-NIR) spectroscopy with principal component regression (PCR) and partial least squares regression (PLS) to build hardwood prediction models. Wet chemistry analysis coupled with high performance liquid chromatography (HPLC) was employed to obtain the chemical composition of these samples. Spectra loadings were studied to identify key wavenumber in the prediction of chemical composition. NIR-PLS and FTIR-PLS performed the best for extractives, lignin and xylose, whose residual predictive deviation (RPD) values were all over 3 and indicates the potential for either instrument to provide superior prediction models with NIR performing slightly better. During testing, it was found that more accurate determination of holocellulose content was possible when HPLC was used. Independent chemometric models, for FT-NIR and ATR-FTIR, identified similar functional groups responsible for the prediction of chemical composition and suggested that coupling the two techniques could strengthen interpretation and prediction.

  11. In-situ Creep Testing Capability Development for Advanced Test Reactor

    Energy Technology Data Exchange (ETDEWEB)

    B. G. Kim; J. L. Rempe; D. L. Knudson; K. G. Condie; B. H. Sencer

    2010-08-01

    Creep is the slow, time-dependent strain that occurs in a material under a constant strees (or load) at high temperature. High temperature is a relative term, dependent on the materials being evaluated. A typical creep curve is shown in Figure 1-1. In a creep test, a constant load is applied to a tensile specimen maintained at a constant temperature. Strain is then measured over a period of time. The slope of the curve, identified in the figure below, is the strain rate of the test during Stage II or the creep rate of the material. Primary creep, Stage I, is a period of decreasing creep rate due to work hardening of the material. Primary creep is a period of primarily transient creep. During this period, deformation takes place and the resistance to creep increases until Stage II, Secondary creep. Stage II creep is a period with a roughly constant creep rate. Stage II is referred to as steady-state creep because a balance is achieved between the work hardening and annealing (thermal softening) processes. Tertiary creep, Stage III, occurs when there is a reduction in cross sectional area due to necking or effective reduction in area due to internal void formation; that is, the creep rate increases due to necking of the specimen and the associated increase in local stress.

  12. Evaluation of Corrosion of the Dummy “EE” Plate 19 in YA Type ATR Fuel Element During Reactor PALM Cycles

    Energy Technology Data Exchange (ETDEWEB)

    Brower, Jeffrey Owen [Idaho National Lab. (INL), Idaho Falls, ID (United States); Glazoff, Michael Vasily [Idaho National Lab. (INL), Idaho Falls, ID (United States); Eiden, Thomas John [Idaho National Lab. (INL), Idaho Falls, ID (United States); Rezvoi, Aleksey Victor [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2016-08-01

    Advanced Test Reactor (ATR) Cycle 153B-1 was a 14-day, high-power, powered axial locator mechanism (PALM) operating cycle that completed on April 12, 2013. Cycle 153B-1 was a typical operating cycle for the ATR and did not result in any unusual plant transients. ATR was started up and shut down as scheduled. The PALM drive physically moves the selected experiments into and out of the core to simulate reactor startup and heat up, and shutdown and cooldown transients, while the reactor remains in steady state conditions. However, after the cycle was over, several thousand of the flow-assisted corrosion pits and “horseshoeing” defects were readily observable on the surface of the several YA-type fuel elements (these are “dummy” plates that contain no fuel). In order understand these corrosion phenomena a thermal-hydraulic model of coolant channel 20 on a YA-M fuel element was generated. The boundaries of the model were the aluminum EE plate of a YA-M fuel element and a beryllium reflector block with 13 horizontal saw cuts which represented regions of zero flow. The heat generated in fuel plates 1 through 18 was modeled to be passing through the aluminum EE plate. The coolant channel 20 width was set at 0.058 in. (58 mils). It was established that the horizontal saw cuts had a significant effect on the temperature of the coolant. The flow, which was expected to vary linearly with gradual heating of the coolant as it passed through the channel, was extremely turbulent. The temperature rise, which was expected to be a smooth “S” curve, was represented by a series temperature rise “humps,” which occurred at each horizontal saw cut in the beryllium reflector block. Each of the 13 saw cuts had a chamfered edge which resulted in the coolant flow being re-directed as a jet across the coolant channel into the surface of the EE plate, which explained the temperature rise and the observed sscalloping and possibly pitting degradation on the YA-M fuel elements. In

  13. Testing of advanced ceramic fabric heat pipe for a Stirling engine

    Energy Technology Data Exchange (ETDEWEB)

    Antoniak, Z.I.; Webb, B.J.; Bates, J.M.

    1991-09-01

    The development and application of Stirling engines for space power production requires concomitant development of an advanced heat rejection system. We are currently involved in the design, development, and testing of advanced ceramic fabric (ACF) water heat pipes for optimal heat rejection from the Stirling cycle without the use of hazardous working fluids such as mercury. Our testing to-date has been with a 200-{mu}m thick titanium heat pipe utilizing Nextel {trademark} fabric as both the outer structural component and as a wick. This heat pipe has been successfully started up from a frozen condition against a negative 4 degree tilt (i.e., fluid return to evaporator was against gravity), with 75 W heat input, in ambient air. In a horizontal orientation, up to 100 W heat input was tolerated without experiencing dryout. 7 refs., 5 figs., 2 tabs.

  14. UTILITY ADVANCED TURBINE SYSTEMS (ATS) TECHNOLOGY READINESS TESTING: PHASE 3R

    Energy Technology Data Exchange (ETDEWEB)

    None

    1999-09-01

    The overall objective of the Advanced Turbine System (ATS) Phase 3 Cooperative Agreement between GE and the US Department of Energy (DOE) is the development of the GE 7H and 9H combined cycle power systems. The major effort will be expended on detail design. Validation of critical components and technologies will be performed, including: hot gas path component testing, sub-scale compressor testing, steam purity test trials, and rotational heat transfer confirmation testing. Processes will be developed to support the manufacture of the first system, which was to have been sited and operated in Phase 4 but will now be sited and operated commercially by GE. This change has resulted from DOE's request to GE for deletion of Phase 4 in favor of a restructured Phase 3 (as Phase 3R) to include full speed, no load (FSNL) testing of the 7H gas turbine. Technology enhancements that are not required for the first machine design but will be critical for future ATS advances in performance, reliability, and costs will be initiated. Long-term tests of materials to confirm design life predictions will continue. A schematic of the GE H machine is shown. This report summarizes work accomplished in 2Q99.

  15. Utility advanced turbine systems (ATS) technology readiness testing. Technical progress report, January 1--March 31, 1998

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-08-01

    The overall objective of the Advanced Turbine System (ATS) Phase 3 Cooperative Agreement between GE and the US Department of Energy (DOE) is the development of the GE 7H and 9H combined cycle power systems. The major effort will be expended on detail design. Validation of critical components and technologies will be performed including: hot gas path component testing, sub-scale compressor testing, steam purity test trials, and rotational heat transfer confirmation testing. Processes will be developed to support the manufacture of the first system, which was to have been sited and operated in Phase 4 but will now be sited and operated commercially by GE. This change has resulted from DOE`s request to GE for deletion of Phase 4 in favor of a restructured Phase 3 (as Phase 3R) to include full speed, no load (FSNL) testing of the 7H gas turbine. Technology enhancements that are not required for the first machine design but will be critical for future ATS advances in performance, reliability, and costs will be initiated. Long-term tests of materials to confirm design life predictions will continue. This report summarizes work accomplished in 1Q98.

  16. Desire for predictive testing for Alzheimer's disease and impact on advance care planning: a cross-sectional study

    National Research Council Canada - National Science Library

    Sheffrin, Meera; Stijacic Cenzer, Irena; Steinman, Michael A

    2016-01-01

    .... Using a nationally representative sample, we explored who would take a free and definitive test predictive of Alzheimer's disease, and examined how using such a test may impact advance care planning...

  17. Wake potentials and impedances for the ATA (Advanced Test Accelerator) induction cell

    Energy Technology Data Exchange (ETDEWEB)

    Craig, G.D.

    1990-09-04

    The AMOS Wakefield Code is used to calculate the impedances of the induction cell used in the Advanced Test Accelerator (ATA) at Livermore. We present the wakefields and impedances for multipoles m = 0, 1 and 2. The ATA cell is calculated to have a maximum transverse impedance of approximately 1000 {Omega}/m at 875 MHz with a quality factor Q = 5. The sensitivity of the impedance spectra to modeling variations is discussed.

  18. Correlation of Simulation Examination to Written Test Scores for Advanced Cardiac Life Support Testing: Prospective Cohort Study

    Directory of Open Access Journals (Sweden)

    Suzanne L. Strom

    2015-11-01

    Full Text Available Introduction: Traditional Advanced Cardiac Life Support (ACLS courses are evaluated using written multiple-choice tests. High-fidelity simulation is a widely used adjunct to didactic content, and has been used in many specialties as a training resource as well as an evaluative tool. There are no data to our knowledge that compare simulation examination scores with written test scores for ACLS courses. Objective: To compare and correlate a novel high-fidelity simulation-based evaluation with traditional written testing for senior medical students in an ACLS course. Methods: We performed a prospective cohort study to determine the correlation between simulationbased evaluation and traditional written testing in a medical school simulation center. Students were tested on a standard acute coronary syndrome/ventricular fibrillation cardiac arrest scenario. Our primary outcome measure was correlation of exam results for 19 volunteer fourth-year medical students after a 32-hour ACLS-based Resuscitation Boot Camp course. Our secondary outcome was comparison of simulation-based vs. written outcome scores. Results: The composite average score on the written evaluation was substantially higher (93.6% than the simulation performance score (81.3%, absolute difference 12.3%, 95% CI [10.6-14.0%], p<0.00005. We found a statistically significant moderate correlation between simulation scenario test performance and traditional written testing (Pearson r=0.48, p=0.04, validating the new evaluation method. Conclusion: Simulation-based ACLS evaluation methods correlate with traditional written testing and demonstrate resuscitation knowledge and skills. Simulation may be a more discriminating and challenging testing method, as students scored higher on written evaluation methods compared to simulation.

  19. ATRS - A Technology-based Solution to Automobility for Wheelchair Users

    OpenAIRE

    Gao, C.; Hoffman, I.; Panzarella, T.; Spletzer, J.

    2007-01-01

    International audience; In this paper, we present the Automated Transport and Retrieval System (ATRS). ATRS represents an alternative to van conversions for automobile drivers with lower body disabilities. It employs robotics and automation technologies that integrate into a standard minivan or sport utility vehicle (SUV). At the core of ATRS is a “smart” wheelchair that navigates between the driver's position and a powered lift at the rear of the vehicle - eliminating the need for an attenda...

  20. Advancing Risk Analysis for Nanoscale Materials: Report from an International Workshop on the Role of Alternative Testing Strategies for Advancement.

    Science.gov (United States)

    Shatkin, J A; Ong, Kimberly J; Beaudrie, Christian; Clippinger, Amy J; Hendren, Christine Ogilvie; Haber, Lynne T; Hill, Myriam; Holden, Patricia; Kennedy, Alan J; Kim, Baram; MacDonell, Margaret; Powers, Christina M; Sharma, Monita; Sheremeta, Lorraine; Stone, Vicki; Sultan, Yasir; Turley, Audrey; White, Ronald H

    2016-08-01

    The Society for Risk Analysis (SRA) has a history of bringing thought leadership to topics of emerging risk. In September 2014, the SRA Emerging Nanoscale Materials Specialty Group convened an international workshop to examine the use of alternative testing strategies (ATS) for manufactured nanomaterials (NM) from a risk analysis perspective. Experts in NM environmental health and safety, human health, ecotoxicology, regulatory compliance, risk analysis, and ATS evaluated and discussed the state of the science for in vitro and other alternatives to traditional toxicology testing for NM. Based on this review, experts recommended immediate and near-term actions that would advance ATS use in NM risk assessment. Three focal areas-human health, ecological health, and exposure considerations-shaped deliberations about information needs, priorities, and the next steps required to increase confidence in and use of ATS in NM risk assessment. The deliberations revealed that ATS are now being used for screening, and that, in the near term, ATS could be developed for use in read-across or categorization decision making within certain regulatory frameworks. Participants recognized that leadership is required from within the scientific community to address basic challenges, including standardizing materials, protocols, techniques and reporting, and designing experiments relevant to real-world conditions, as well as coordination and sharing of large-scale collaborations and data. Experts agreed that it will be critical to include experimental parameters that can support the development of adverse outcome pathways. Numerous other insightful ideas for investment in ATS emerged throughout the discussions and are further highlighted in this article.

  1. Pilot Test of Advanced Treatments Combination of Wastewater for Groundwater Recharge

    Institute of Scientific and Technical Information of China (English)

    成徐洲; 杨磊; 吴天宝; 甘一苹; 胡俊

    2002-01-01

    To solve the water shortage problem, an artificial groundwater recharge system will be constructed in Beijing for wastewater reuse as a demonstration and training center. Design and operating experience for the demonstration plant was gained through pilot tests of advanced treatment technologies with soil infiltration of well treated secondary effluent. The test results showed that the selected treatment technology meets the recommended water quality criteria for groundwater recharge and the gas chromatography-mass spectrometer (GC/MS) analysis results showed significantly improved water quality.

  2. Structural transformation of synthetic hydroxyapatite under simulated in vivo conditions studied with ATR-FTIR spectroscopic imaging

    Science.gov (United States)

    Sroka-Bartnicka, Anna; Borkowski, Leszek; Ginalska, Grazyna; Ślósarczyk, Anna; Kazarian, Sergei G.

    2017-01-01

    Hydroxyapatite and carbonate-substituted hydroxyapatite are widely used in bone tissue engineering and regenerative medicine. Both apatite materials were embedded into recently developed ceramic/polymer composites, subjected to Simulated Body Fluid (SBF) for 30 days and characterized using ATR-FTIR spectroscopic imaging to assess their behaviour and structures. The specific aim was to detect the transition phases between both types of hydroxyapatite during the test and to analyze the surface modification caused by SBF. ATR-FTIR spectroscopic imaging was successfully applied to characterise changes in the hydroxyapatite lattice due to the elastic properties of the scaffolds. It was observed that SBF treatment caused a replacement of phosphates in the lattice of non-substituted hydroxyapatite by carbonate ions. A detailed study excluded the formation of pure A type carbonate apatite. In turn, CO32- content in synthetic carbonate-substituted hydroxyapatite decreased. The usefulness of ATR-FTIR spectroscopic imaging studies in the evaluation of elastic and porous β-glucan hydroxyapatite composites has been demonstrated.

  3. Hollow Fiber Spacesuit Water Membrane Evaporator Development and Testing for Advanced Spacesuits

    Science.gov (United States)

    Bue, Grant C.; Trevino, Luis A.; Tsioulos, Gus; Settles, Joseph; Colunga, Aaron; Vogel, Matthew; Vonau, Walt

    2010-01-01

    The spacesuit water membrane evaporator (SWME) is being developed to perform the thermal control function for advanced spacesuits to take advantage of recent advances in micropore membrane technology in providing a robust heat-rejection device that is potentially less sensitive to contamination than is the sublimator. Principles of a sheet membrane SWME design were demonstrated using a prototypic test article that was tested in a vacuum chamber at JSC in July 1999. The Membrana Celgard X50-215 microporous hollow fiber (HoFi) membrane was selected after recent contamination tests as the most suitable candidate among commercial alternatives for HoFi SWME prototype development. A design that grouped the fiber layers into stacks, which were separated by small spaces and packaged into a cylindrical shape, was developed into a full-scale prototype consisting 14,300 tube bundled into 30 stacks, each of which are formed into a chevron shape and separated by spacers and organized into three sectors of ten nested stacks. Vacuum chamber testing has been performed characterize heat rejection as a function of inlet water temperature and water vapor backpressure and to show contamination resistance to the constituents expected to be found in potable water produced by the distillation processes. Other tests showed the tolerance to freezing and suitability to reject heat in a Mars pressure environment.

  4. Test Report for Acceptance Test Procedure for Pumping Instrumentation and Control Skid P

    Energy Technology Data Exchange (ETDEWEB)

    KOCH, M.R.

    2000-03-29

    This Acceptance Test Report (ATR) provides the test results for the inspection and testing of the new Pumping Instrumentation and Control (PIC) skid designed as ''P''. The ATR summaries the results and provides a copy of the ATP and inspections in the Appendix.

  5. Test Report for Acceptance Test Procedure for Pumping Instrumentation and Control Skid Q

    Energy Technology Data Exchange (ETDEWEB)

    KOCH, M.R.

    2000-05-11

    This Acceptance Test Report (ATR) provides the test results for the inspection and testing of the new Pumping Instrumentation and Control (PIC) skid designed as ''Q''. The ATR summaries the results and provides a copy of the ATP and inspections in the Appendix.

  6. Test Requirements and Conceptual Design for a Potassium Test Loop to Support an Advanced Potassium Rankine Cycle Power Conversion Systems

    Energy Technology Data Exchange (ETDEWEB)

    Yoder, JR.G.L.

    2006-03-08

    Parameters for continuing the design and specification of an experimental potassium test loop are identified in this report. Design and construction of a potassium test loop is part of the Phase II effort of the project ''Technology Development Program for an Advanced Potassium Rankine Power Conversion System''. This program is supported by the National Aeronautics and Space Administration. Design features for the potassium test loop and its instrumentation system, specific test articles, and engineered barriers for ensuring worker safety and protection of the environment are described along with safety and environmental protection requirements to be used during the design process. Information presented in the first portion of this report formed the basis to initiate the design phase of the program; however, the report is a living document that can be changed as necessary during the design process, reflecting modifications as additional design details are developed. Some portions of the report have parameters identified as ''to be determined'' (TBD), reflecting the early stage of the overall process. In cases where specific design values are presently unknown, the report attempts to document the quantities that remain to be defined in order to complete the design of the potassium test loop and supporting equipment.

  7. THERMAL PREDICTIONS OF NEW COMPOSITE MATERIAL DURING INPILE TESTING

    Energy Technology Data Exchange (ETDEWEB)

    Donna Post Guillen; W. David Swank; Heng Ban; Kurt Harris; Adam Zabriskie

    2011-09-01

    An inpile experiment is currently underway wherein specimens comprised of a newly developed material are being irradiated at Idaho National Laboratory's Advanced Test Reactor (ATR) in conjunction with Utah State University under the auspices of the ATR National Scientific User Facility. This paper provides the thermophysical properties of this new material measured prior to irradiation. After the irradiation campaign is complete, the thermophysical properties of the specimens will be measured and compared to the preirradiation values. A finite-element model was constructed to predict bounding specimen temperatures during irradiation. Results from the thermal hydraulic modeling, including the steady-state temperatures of the specimens within sealed capsules, are presented. After the irradiation campaign is completed, best-estimate thermal predictions will be performed for the individual specimens using the actual as-run irradiation power levels.

  8. The Down Syndrome Information Act: Balancing the Advances of Prenatal Testing Through Public Policy.

    Science.gov (United States)

    Leach, Mark W

    2016-04-01

    Since the dawn of prenatal testing in the 1970s, concerns have been raised over its administration to respect a mother's autonomy as well as the expressive critique against those with the tested-for condition. Advances in prenatal testing have made it such that more mothers than ever are given a test result of Down syndrome, yet are not provided the rest of the information recommended by professional guidelines. In response, first federal legislation and then, increasingly, state legislation is requiring that this information be provided to expectant mothers. Though receiving broad bipartisan support in passage, some of the statutes have received criticism. These public policy measures will be surveyed and evaluated as to their relative merits and limitations.

  9. Smart-DS: Synthetic Models for Advanced, Realistic Testing: Distribution Systems and Scenarios

    Energy Technology Data Exchange (ETDEWEB)

    Krishnan, Venkat K [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Palmintier, Bryan S [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Hodge, Brian S [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Hale, Elaine T [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Elgindy, Tarek [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Bugbee, Bruce [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Rossol, Michael N [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Lopez, Anthony J [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Krishnamurthy, Dheepak [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Vergara, Claudio [MIT; Domingo, Carlos Mateo [IIT Comillas; Postigo, Fernando [IIT Comillas; de Cuadra, Fernando [IIT Comillas; Gomez, Tomas [IIT Comillas; Duenas, Pablo [MIT; Luke, Max [MIT; Li, Vivian [MIT; Vinoth, Mohan [GE Grid Solutions; Kadankodu, Sree [GE Grid Solutions

    2017-08-09

    The National Renewable Energy Laboratory (NREL) in collaboration with Massachusetts Institute of Technology (MIT), Universidad Pontificia Comillas (Comillas-IIT, Spain) and GE Grid Solutions, is working on an ARPA-E GRID DATA project, titled Smart-DS, to create: 1) High-quality, realistic, synthetic distribution network models, and 2) Advanced tools for automated scenario generation based on high-resolution weather data and generation growth projections. Through these advancements, the Smart-DS project is envisioned to accelerate the development, testing, and adoption of advanced algorithms, approaches, and technologies for sustainable and resilient electric power systems, especially in the realm of U.S. distribution systems. This talk will present the goals and overall approach of the Smart-DS project, including the process of creating the synthetic distribution datasets using reference network model (RNM) and the comprehensive validation process to ensure network realism, feasibility, and applicability to advanced use cases. The talk will provide demonstrations of early versions of synthetic models, along with the lessons learnt from expert engagements to enhance future iterations. Finally, the scenario generation framework, its development plans, and co-ordination with GRID DATA repository teams to house these datasets for public access will also be discussed.

  10. The role of ATR kinase during mammalian gametogenesis

    OpenAIRE

    Pacheco Piñol, Sarai

    2015-01-01

    ATR és una proteïna cinasa essencial per a la viabilitat cel·lular que participa en els mecanismes de resposta al dany en el DNA per tal de mantenir la integritat del genoma. Aquesta proteïna es activada en resposta a regions de cadena simple del DNA (ssDNA) generades per la resecció dels trencaments de doble cadena (DSBs) i controla la progressió de les forques de replicació durant la fase S del cicle cel·lular. Durant la meiosi, un tipus de divisió cel·lular especialitzada per la qual les c...

  11. Molecular-clinical spectrum of the ATR-X syndrome.

    Science.gov (United States)

    Gibbons, R J; Higgs, D R

    2000-01-01

    Since the identification of the ATRX gene (synonyms XNP, XH2) in 1995, it has been shown to be the disease gene for numerous forms of syndromal X-linked mental retardation [X-linked alpha thalassemia/mental retardation (ATR-X) syndrome, Carpenter syndrome, Juberg-Marsidi syndrome, Smith-Fineman-Myers syndrome, X-linked mental retardation with spastic paraplegia]. An attempt is made in this article to review the clinical spectrum associated with ATRX mutations and to analyse the evidence for any genotype/phenotype correlation.

  12. UCSB ATR-­NSUF Irradiation DMC Sample Inspection Report

    Energy Technology Data Exchange (ETDEWEB)

    Saleh, Tarik A. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Quintana, Matthew Estevan [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Romero, Tobias J. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2015-02-23

    A variety of tensile samples of Ferritic and Oxide Dispersion Strengthened (ODS or nanoferritic) steels were placed the ATR reactor over 2 Years achieving doses of roughly 4-6 dpa at temperatures of roughly 290°C. After irradiation, samples were shipped from the MFC hot cells at Idaho National Laboratory (INL) to the Wing 9 hot cells in the CMR facility at Los Alamos National Laboratory. Samples were cleaned to removed alpha contamination from the MFC hot cells, and then, as needed removed from their irradiation containers, sorted and inspected. This report will summarize the inspection of the Disc Multipurpose Coupon (DMC) inspection from packet 7-1.

  13. Rapid detection of NBOME's and other NPS on blotter papers by direct ATR-FTIR spectrometry.

    Science.gov (United States)

    Coelho Neto, José

    2015-07-01

    Blotter paper is among the most common forms of consumption of new psychotropic substances (NPS), formerly referred as designer drugs. In many cases, users are misled to believe they are taking LSD when, in fact, they are taking newer and less known drugs like the NBOMEs or other substituted phenethylamines. We report our findings in quick testing of blotter papers for illicit substances like NBOMEs and other NPS by taking ATR-FTIR spectra directly from blotters seized on the streets, without any sample preparation. Both sides (front and back) of each blotter were tested. Collected data were analyzed by single- and multi-component spectral matching and submitted to chemometric discriminant analysis. Our results showed that, on 66.7% of the cases analyzed, seized blotters contained one or more types of NBOMEs, confirming the growing presence of this novel substances on the market. Matching IR signals were detected on both or just one side of the blotters and showed variable strength. Although no quantitative analysis was made, detection of these substances by the proposed approach serves as indication of variable and possibly higher dosages per blotter when compared to LSD, which showed to be below the detection limit of the applied method. Blotters containing a mescaline-like compound, later confirmed by GC-MS and LC-MS to be MAL (methallylescaline), a substance very similar to mescaline, were detected among the samples tested. Validity of direct ATR-FTIR testing was confirmed by checking the obtained results against independent GC-MS or LC-MS results for the same cases/samples.

  14. Within-day test-retest reliability of the Timed Up & Go test in patients with advanced chronic organ failure.

    Science.gov (United States)

    Mesquita, Rafael; Janssen, Daisy J A; Wouters, Emiel F M; Schols, Jos M G A; Pitta, Fabio; Spruit, Martijn A

    2013-11-01

    To investigate the within-day test-retest reliability of the Timed Up & Go (TUG) test in patients with advanced chronic obstructive pulmonary disease (COPD), chronic heart failure (CHF), and chronic renal failure (CRF). Cross-sectional. Patients' home environment. Subjects (N=235, 64% men; median age, 70y [interquartile range, 61-77y]; median body mass index, 25.6kg/m(2) [interquartile range, 22.8-29.4kg/m(2)]) with advanced COPD (n=95), CHF (n=68), or CRF (n=72). Not applicable. Time to complete the TUG test. Three trials were performed on the same day and by the same assessors. The intraclass correlation coefficient (ICC), kappa coefficient, standard error of measurement, and absolute and relative minimal detectable change (MDC) values were calculated. Good agreement was observed, in general, for both the total sample and subgroups (COPD, CHF, CRF), with ICC values ranging from .85 to .98, and kappa coefficients from .49 to 1.00. However, statistical improvement occurred in the total sample from the first to the second trial with large limits of agreement (mean difference, -.97s; 95% confidence interval, 3.00 to -4.94s; P<.01). The third trial added little or no information to the first 2 trials. For the total sample, a standard error of measurement value of approximately 1.6 seconds, an absolute value of MDC at the 95% confidence level (MDC95%) of approximately 4.5 seconds, and a relative value of MDC at the 95% confidence level (MDC95%%) of approximately 35% were found between the first 2 trials, with similar values found for the subgroups. The TUG test is reliable in patients with advanced COPD, CHF, or CRF after 2 trials. Values of standard error of measurement and MDC may be used in daily clinical practice with these populations to define what is expected and what represents true change in repeated measures. Copyright © 2013 American Congress of Rehabilitation Medicine. Published by Elsevier Inc. All rights reserved.

  15. RECENT ADVANCES IN HIGH TEMPERATURE ELECTROLYSIS AT IDAHO NATIONAL LABORATORY: STACK TESTS

    Energy Technology Data Exchange (ETDEWEB)

    X, Zhang; J. E. O' Brien; R. C. O' Brien; J. J. Hartvigsen; G. Tao; N. Petigny

    2012-07-01

    High temperature steam electrolysis is a promising technology for efficient sustainable large-scale hydrogen production. Solid oxide electrolysis cells (SOECs) are able to utilize high temperature heat and electric power from advanced high-temperature nuclear reactors or renewable sources to generate carbon-free hydrogen at large scale. However, long term durability of SOECs needs to be improved significantly before commercialization of this technology. A degradation rate of 1%/khr or lower is proposed as a threshold value for commercialization of this technology. Solid oxide electrolysis stack tests have been conducted at Idaho National Laboratory to demonstrate recent improvements in long-term durability of SOECs. Electrolytesupported and electrode-supported SOEC stacks were provided by Ceramatec Inc., Materials and Systems Research Inc. (MSRI), and Saint Gobain Advanced Materials (St. Gobain), respectively for these tests. Long-term durability tests were generally operated for a duration of 1000 hours or more. Stack tests based on technology developed at Ceramatec and MSRI have shown significant improvement in durability in the electrolysis mode. Long-term degradation rates of 3.2%/khr and 4.6%/khr were observed for MSRI and Ceramatec stacks, respectively. One recent Ceramatec stack even showed negative degradation (performance improvement) over 1900 hours of operation. A three-cell short stack provided by St. Gobain, however, showed rapid degradation in the electrolysis mode. Improvements on electrode materials, interconnect coatings, and electrolyteelectrode interface microstructures contribute to better durability of SOEC stacks.

  16. A case of advanced intrahepatic cholangiocarcinoma successfully treated with chemosensitivity test-guided systemic chemotherapy

    Institute of Scientific and Technical Information of China (English)

    Kazumichi Abe; Takeru Wakatsuki; Fumiko Katsushima; Kyoko Monoe; Yukiko Kanno; Atsushi Takahashi; Junko Yokokawa; Hiromasa Ohira

    2009-01-01

    Intrahepatic cholangiocarcinoma (ICC) is a relatively rare and highly fatal neoplasm that arises from the biliary epithelium. Prognosis is generally poor and survival is limited to a few months. Here we present a case of advanced ICC successfully treated by chemosensitivity test-guided systemic chemotherapy combining S-1 and cisplatin (CDDP). A 65-year-old woman with a liver tumor was referred to our hospital on November 21, 2007. Abdominal ultrasonography and computed tomography (CT) showed low-density masses of 50 and 15 mm in diameter, respectively in segment Ⅷ of the liver and in the enlarged lymph node in the para-aorta. Ultrasonography-guided fine needle biopsy diagnosed the tumors as ICC. Since the patient was inoperable for lymph node metastasis, she underwent systemic chemotherapy with gemcitabine. Six months after initiation of chemotherapy, CT revealed ICC progression in the liver and pleural dissemination with pleural effusion. The patient was admitted to our hospital for anticancer drug sensitivity testing on June 9, 2008. Based on the sensitivity test results, we elected to administer systemic chemotherapy combining S-1 and CDDP. Two months into the second chemotherapy treatment, CT revealed a reduction of the tumors in the liver and lymph node and a decrease in pleural effusion.After eight cycles of the second chemotherapy, 17 mo after ICC diagnosis, she is alive and well with no sign of recurrence. We conclude that chemosensitivity testing may effectively determine the appropriate chemotherapy regimen for advanced ICC.

  17. Full-Scale Hollow Fiber Spacesuit Water Membrane Evaporator Prototype Development and Testing for Advanced Spacesuits

    Science.gov (United States)

    Bue, Grant; Trevino, Luis; Tsioulos, Gus; Mitchell, Keith; Dillon, Paul; Weaver, Gregg

    2009-01-01

    The spacesuit water membrane evaporator (SWME) is being developed to perform the thermal control function for advanced spacesuits to take advantage of recent advances in micropore membrane technology in providing a robust heat-rejection device that is potentially less sensitive to contamination than is the sublimator. Principles of a sheet membrane SWME design were demonstrated using a prototypic test article that was tested in a vacuum chamber at JSC in July 1999. The Membrana Celgard X50-215 microporous hollow fiber (HoFi) membrane was selected after recent contamination tests as the superior candidate among commercial alternatives for HoFi SWME prototype development. Although a number of design variants were considered, one that grouped the fiber layers into stacks, which were separated by small spaces and packaged into a cylindrical shape, was deemed best for further development. An analysis of test data showed that eight layer stacks of the HoFi sheets that had good exposure on each side of the stack would evaporate water with high efficiency. A design that has 15,000 tubes, with 18 cm of exposed tubes between headers has been built and tested that meets the size, weight, and performance requirements of the SWME. This full-scale prototype consists of 30 stacks, each of which are formed into a chevron shape and separated by spacers and organized into three sectors of ten nested stacks. Testing has been performed to show contamination resistance to the constituents expected to be found in potable water produced by the distillation processes. Other tests showed the sensitivity to surfactants.

  18. Completion summary for borehole USGS 136 near the Advanced Test Reactor Complex, Idaho National Laboratory, Idaho

    Science.gov (United States)

    Twining, Brian V.; Bartholomay, Roy C.; Hodges, Mary K.V.

    2012-01-01

    In 2011, the U.S. Geological Survey, in cooperation with the U.S. Department of Energy, cored and completed borehole USGS 136 for stratigraphic framework analyses and long-term groundwater monitoring of the eastern Snake River Plain aquifer at the Idaho National Laboratory. The borehole was initially cored to a depth of 1,048 feet (ft) below land surface (BLS) to collect core, open-borehole water samples, and geophysical data. After these data were collected, borehole USGS 136 was cemented and backfilled between 560 and 1,048 ft BLS. The final construction of borehole USGS 136 required that the borehole be reamed to allow for installation of 6-inch (in.) diameter carbon-steel casing and 5-in. diameter stainless-steel screen; the screened monitoring interval was completed between 500 and 551 ft BLS. A dedicated pump and water-level access line were placed to allow for aquifer testing, for collecting periodic water samples, and for measuring water levels. Geophysical and borehole video logs were collected after coring and after the completion of the monitor well. Geophysical logs were examined in conjunction with the borehole core to describe borehole lithology and to identify primary flow paths for groundwater, which occur in intervals of fractured and vesicular basalt. A single-well aquifer test was used to define hydraulic characteristics for borehole USGS 136 in the eastern Snake River Plain aquifer. Specific-capacity, transmissivity, and hydraulic conductivity from the aquifer test were at least 975 gallons per minute per foot, 1.4 × 105 feet squared per day (ft2/d), and 254 feet per day, respectively. The amount of measureable drawdown during the aquifer test was about 0.02 ft. The transmissivity for borehole USGS 136 was in the range of values determined from previous aquifer tests conducted in other wells near the Advanced Test Reactor Complex: 9.5 × 103 to 1.9 × 105 ft2/d. Water samples were analyzed for cations, anions, metals, nutrients, total organic

  19. International on Workshop Advances in Laboratory Testing & Modelling of Soils and Shales

    CERN Document Server

    Laloui, Lyesse

    2017-01-01

    In this spirit, the ATMSS International Workshop “Advances in Laboratory Testing & Modelling of Soils and Shales” (Villars-sur-Ollon, Switzerland; 18-20 January 2017) has been organized to promote the exchange of ideas, experience and state of the art among major experts active in the field of experimental testing and modelling of soils and shales. The Workshop has been organized under the auspices of the Technical Committees TC-101 “Laboratory Testing”, TC-106 “Unsaturated Soils” and TC-308 “Energy Geotechnics” of the International Society of Soil Mechanics and Geotechnical Engineering. This volume contains the invited keynote and feature lectures, as well as the papers that have been presented at the Workshop. The topics of the lectures and papers cover a wide range of theoretical and experimental research, including unsaturated behaviour of soils and shales, multiphysical testing of geomaterials, hydro–mechanical behaviour of shales and stiff clays, the geomechanical behaviour of the ...

  20. TOPICAL REVIEW: Recent advances in the fabrication and adhesion testing of biomimetic dry adhesives

    Science.gov (United States)

    Sameoto, D.; Menon, C.

    2010-10-01

    In the past two years, there have been a large number of publications on the topic of biomimetic dry adhesives from modeling, fabrication and testing perspectives. We review and compare the most recent advances in fabrication and testing of these materials. While there is increased convergence and consensus as to what makes a good dry adhesive, the fabrication of these materials is still challenging, particularly for anisotropic or hierarchal designs. Although qualitative comparisons between different adhesive designs can be made, quantifying the exact performance and rating each design is significantly hampered by the lack of standardized testing methods. Manufacturing dry adhesives, which can reliably adhere to rough surfaces, show directional and self-cleaning behavior and are relatively simple to manufacture, is still very challenging—great strides by multiple research groups have however made these goals appear achievable within the next few years.

  1. Advancing Risk Analysis for Nanoscale Materials: Report from an International Workshop on the Role of Alternative Testing Strategies for Advancement: Advancing Risk Analysis for Nanoscale Materials

    Energy Technology Data Exchange (ETDEWEB)

    Shatkin, J. A. [Vireo Advisors, Boston MA USA; Ong, Kimberly J. [Vireo Advisors, Boston MA USA; Beaudrie, Christian [Compass RM, Vancouver CA USA; Clippinger, Amy J. [PETA International Science Consortium Ltd, London UK; Hendren, Christine Ogilvie [Center for the Environmental Implications of NanoTechnology, Duke University, Durham NC USA; Haber, Lynne T. [TERA, Cincinnati OH USA; Hill, Myriam [Health Canada, Ottawa Canada; Holden, Patricia [UC Santa Barbara, Bren School of Environmental Science & Management, ERI, and UC CEIN, University of California, Santa Barbara CA USA; Kennedy, Alan J. [U.S. Army Engineer Research and Development Center, Environmental Laboratory, Vicksburg MS USA; Kim, Baram [Independent, Somerville MA USA; MacDonell, Margaret [Argonne National Laboratory, Environmental Science Division, Argonne IL USA; Powers, Christina M. [U.S. Environmental Protection Agency, Office of Air and Radiation, Office of Transportation and Air Quality, Ann Arbor MI USA; Sharma, Monita [PETA International Science Consortium Ltd, London UK; Sheremeta, Lorraine [Alberta Ingenuity Labs, Edmonton Alberta Canada; Stone, Vicki [John Muir Building Gait 1 Heriot-Watt University, Edinburgh Scotland UK; Sultan, Yasir [Environment Canada, Gatineau QC Canada; Turley, Audrey [ICF International, Durham NC USA; White, Ronald H. [RH White Consultants, Silver Spring MD USA

    2016-08-01

    The Society for Risk Analysis (SRA) has a history of bringing thought leadership to topics of emerging risk. In September 2014, the SRA Emerging Nanoscale Materials Specialty Group convened an international workshop to examine the use of alternative testing strategies (ATS) for manufactured nanomaterials (NM) from a risk analysis perspective. Experts in NM environmental health and safety, human health, ecotoxicology, regulatory compliance, risk analysis, and ATS evaluated and discussed the state of the science for in vitro and other alternatives to traditional toxicology testing for NM. Based on this review, experts recommended immediate and near-term actions that would advance ATS use in NM risk assessment. Three focal areas-human health, ecological health, and exposure considerations-shaped deliberations about information needs, priorities, and the next steps required to increase confidence in and use of ATS in NM risk assessment. The deliberations revealed that ATS are now being used for screening, and that, in the near term, ATS could be developed for use in read-across or categorization decision making within certain regulatory frameworks. Participants recognized that leadership is required from within the scientific community to address basic challenges, including standardizing materials, protocols, techniques and reporting, and designing experiments relevant to real-world conditions, as well as coordination and sharing of large-scale collaborations and data. Experts agreed that it will be critical to include experimental parameters that can support the development of adverse outcome pathways. Numerous other insightful ideas for investment in ATS emerged throughout the discussions and are further highlighted in this article.

  2. High Current ESD Test of Advanced Triple Junction Solar Array Coupon

    Science.gov (United States)

    Wright, Kenneth H., Jr.; Schneider, Todd A.; Vaughn, Jason A.; Hoang, Bao; Wong, Frankie

    2014-01-01

    Testing was conducted on an Advanced Triple Junction (ATJ) coupon that was part of a risk reduction effort in the development of a high-powered solar array design by Space Systems Loral, LLC (SSL). The ATJ coupon was a small, 4-cell, two-string configuration of flight-type design that has served as the basic test coupon design used in previous SSL environmental aging campaigns. The objective of the present test was to evaluate the performance of the coupon after being subjected to induced electrostatic discharge (ESD) testing at two string voltages (100 V, 150 V) and four string currents (1.65 A, 2.0 A, 2.475 A, and 3.3 A). An ESD test circuit, unique to SSL solar array design, was built that simulates the effect of missing cells and strings in a full solar panel with special primary arc flashover circuitry. A total of 73 primary arcs were obtained that included 7 temporary sustained arcs (TSA) events. The durations of the TSAs ranged from 50 micro-seconds to 2.75 milli-seconds. All TSAs occurred at a string voltage of 150 V. Post-ESD functional testing showed that no degradation occurred due to the TSA events. These test results point to a robust design for application to a high-current, high-power mission.

  3. Structural Benchmark Creep Testing for the Advanced Stirling Convertor Heater Head

    Science.gov (United States)

    Krause, David L.; Kalluri, Sreeramesh; Bowman, Randy R.; Shah, Ashwin R.

    2008-01-01

    The National Aeronautics and Space Administration (NASA) has identified the high efficiency Advanced Stirling Radioisotope Generator (ASRG) as a candidate power source for use on long duration Science missions such as lunar applications, Mars rovers, and deep space missions. For the inherent long life times required, a structurally significant design limit for the heater head component of the ASRG Advanced Stirling Convertor (ASC) is creep deformation induced at low stress levels and high temperatures. Demonstrating proof of adequate margins on creep deformation and rupture for the operating conditions and the MarM-247 material of construction is a challenge that the NASA Glenn Research Center is addressing. The combined analytical and experimental program ensures integrity and high reliability of the heater head for its 17-year design life. The life assessment approach starts with an extensive series of uniaxial creep tests on thin MarM-247 specimens that comprise the same chemistry, microstructure, and heat treatment processing as the heater head itself. This effort addresses a scarcity of openly available creep properties for the material as well as for the virtual absence of understanding of the effect on creep properties due to very thin walls, fine grains, low stress levels, and high-temperature fabrication steps. The approach continues with a considerable analytical effort, both deterministically to evaluate the median creep life using nonlinear finite element analysis, and probabilistically to calculate the heater head s reliability to a higher degree. Finally, the approach includes a substantial structural benchmark creep testing activity to calibrate and validate the analytical work. This last element provides high fidelity testing of prototypical heater head test articles; the testing includes the relevant material issues and the essential multiaxial stress state, and applies prototypical and accelerated temperature profiles for timely results in a

  4. NICT/ATR Chinese-Japanese-English Speech-to-Speech Translation System

    Institute of Scientific and Technical Information of China (English)

    Tohru Shimizu; Yutaka Ashikari; Eiichiro Sumita; ZHANG Jinsong; Satoshi Nakamura

    2008-01-01

    This paper describes the latest version of the Chinese-Japanese-English handheld speech-to-speech translation system developed by NICT/ATR,which is now ready to be deployed for travelers.With the entire speech-to-speech translation function being implemented into one terminal,it realizes real-time,location-free speech-to-speech translation.A new noise-suppression technique notably improves the speech recognition performance.Corpus-based approaches of speech recognition,machine translation,and speech synthesis enable coverage of a wide variety of topics and portability to other languages.Test results show that the character accuracy of speech recognition is 82%-94% for Chinese speech,with a bilingual evaluation understudy score of machine translation is 0.55-0.74 for Chinese-Japanese and Chinese-English.

  5. Assessment of Advanced Life Support competence when combining different test methods--reliability and validity

    DEFF Research Database (Denmark)

    Ringsted, C; Lippert, F; Hesselfeldt, R

    2007-01-01

    Summary Robust assessment of Advanced Life Support (ALS) competence is paramount to the credibility of ALS-provider certification and for estimating the learning outcome and retention of ALS competence following the courses. The Euro- pean Resuscitation Council (ERC) provides two sets of MCQs and...... Correlation Coefficients between 0.766 and 0.977. Inter-rater agreements on pass/fail decisions were not perfect. The one MCQ test was significantly more difficult than the other. There were no significant differences between CASTests....

  6. Planned High-brightness Channeling Radiation Experiment at Fermilab's Advanced Superconducting Test Accelerator

    Energy Technology Data Exchange (ETDEWEB)

    Blomberg, Ben [NICADD, DeKalb; Mihalcea, Daniel [NICADD, DeKalb; Panuganti, Harsha [NICADD, DeKalb; Piot, Philippe [Fermilab; Brau, Charles [Vanderbilt U.; Choi, Bo [Vanderbilt U.; Gabella, William [Vanderbilt U.; Ivanov, Borislav [Vanderbilt U.; Mendenhall, Marcus [Vanderbilt U.; Lynn, Christopher [Swarthmore Coll.; Sen, Tanaji [Fermilab; Wagner, Wolfgang [Forschungszentrum Dresden Rossendorf

    2014-07-01

    In this contribution we describe the technical details and experimental setup of our study aimed at producing high-brightness channeling radiation (CR) at Fermilab’s new user facility the Advanced Superconducting Test Accelerator (ASTA). In the ASTA photoinjector area electrons are accelerated up to 40-MeV and focused to a sub-micron spot on a ~40 micron thick carbon diamond, the electrons channel through the crystal and emit CR up to 80-KeV. Our study utilizes ASTA’s long pulse train capabilities and ability to preserve ultra-low emittance, to produce the desired high average brightness.

  7. Benchmarking techniques for evaluation of compression transform performance in ATR applications

    Science.gov (United States)

    Schmalz, Mark S.

    2004-10-01

    Image compression is increasingly employed in applications such as medical imaging, for reducing data storage requirement, and Internet video transmission, to effectively increase channel bandwidth. Similarly, military applications such as automated target recognition (ATR) often employ compression to achieve storage and communication efficiencies, particularly to enhance the effective bandwidth of communication channels whose throughput suffers, for example, from overhead due to error correction/detection or encryption. In the majority of cases, lossy compression is employed due the resultant low bit rates (high compression ratio). However, lossy compression produces artifacts in decompressed imagery that can confound ATR processes applied to such imagery, thereby reducing the probability of detection (Pd) and possibly increasing the rate or number of false alarms (Rfa or Nfa). In this paper, the authors' previous research in performance measurement of compression transforms is extended to include (a) benchmarking algorithms and software tools, (b) a suite of error exemplars that are designed to elicit compression transform behavior in an operationally relevant context, and (c) a posteriori analysis of performance data. The following transforms are applied to a suite of 64 error exemplars: Visual Pattern Image Coding (VPIC [1]), Vector Quantization with a fast codebook search algorithm (VQ [2,3]), JPEG and a preliminary implementation of JPEG 2000 [4,5], and EBLAST [6-8]. Compression ratios range from 2:1 to 200:1, and various noise levels and types are added to the error exemplars to produce a database of 7,680 synthetic test images. Several global and local (e.g., featural) distortion measures are applied to the decompressed test imagery to provide a basis for rate-distortion and rate-performance analysis as a function of noise and compression transform type.

  8. Prognostic significance of performing universal HER2 testing in cases of advanced gastric cancer.

    Science.gov (United States)

    Jiménez-Fonseca, Paula; Carmona-Bayonas, Alberto; Sánchez Lorenzo, Maria Luisa; Plazas, Javier Gallego; Custodio, Ana; Hernández, Raquel; Garrido, Marcelo; García, Teresa; Echavarría, Isabel; Cano, Juana María; Rodríguez Palomo, Alberto; Mangas, Monserrat; Macías Declara, Ismael; Ramchandani, Avinash; Visa, Laura; Viudez, Antonio; Buxó, Elvira; Díaz-Serrano, Asunción; López, Carlos; Azkarate, Aitor; Longo, Federico; Castañón, Eduardo; Sánchez Bayona, Rodrigo; Pimentel, Paola; Limón, Maria Luisa; Cerdá, Paula; Álvarez Llosa, Renata; Serrano, Raquel; Lobera, Maria Pilar Felices; Alsina, María; Hurtado Nuño, Alicia; Gómez-Martin, Carlos

    2017-05-01

    Trastuzumab significantly improves overall survival (OS) when added to cisplatin and fluoropyrimidine as a treatment for HER2-positive advanced gastric cancers (AGC). The aim of this study was to evaluate the impact of the gradual implementation of HER2 testing on patient prognosis in a national registry of AGC. This Spanish National Cancer Registry includes cases who were consecutively recruited at 28 centers from January 2008 to January 2016. The effect of missing HER2 status was assessed using stratified Cox proportional hazards (PH) regression. The rate of HER2 testing increased steadily over time, from 58.3 % in 2008 to 92.9 % in 2016. HER2 was positive in 194 tumors (21.3 %). In the stratified Cox PH regression, each 1 % increase in patients who were not tested for HER2 at the institutions was associated with an approximately 0.3 % increase in the risk of death: hazard ratio, 1.0035 (CI 95 %, 1.001-1.005), P = 0.0019. Median OS was significantly lower at institutions with the highest proportions of patients who were not tested for HER2. Patients treated at centers that took longer to implement HER2 testing exhibited worse clinical outcomes. The speed of implementation behaves as a quality-of-care indicator. Reviewed guidelines on HER2 testing should be used to achieve this goal in a timely manner.

  9. Advanced Grid Simulator for Multi-Megawatt Power Converter Testing and Certification

    Energy Technology Data Exchange (ETDEWEB)

    Koralewicz, Przemyslaw; Gevorgian, Vahan; Wallen, Robb; van der Merwe, Wim; Jorg, Pieder

    2017-02-16

    Grid integration testing of inverter-coupled renewable energy technologies is an essential step in the qualification of renewable energy and energy storage systems to ensure the stability of the power system. New types of devices must be thoroughly tested and validated for compliance with relevant grid codes and interconnection requirements. For this purpose, highly specialized custom-made testing equipment is needed to emulate various types of realistic grid conditions that are required by certification bodies or for research purposes. For testing multi-megawatt converters, a high power grid simulator capable of creating controlled grid conditions and meeting both power quality and dynamic characteristics is needed. This paper describes the new grid simulator concept based on ABB's medium voltage ACS6000 drive technology that utilizes advanced modulation and control techniques to create an unique testing platform for various multi-megawatt power converter systems. Its performance is demonstrated utilizing the test results obtained during commissioning activities at the National Renewable Energy Laboratory in Colorado, USA.

  10. Implementation and Initial Testing of Advanced Processing and Analysis Algorithms for Correlated Neutron Counting

    Energy Technology Data Exchange (ETDEWEB)

    Santi, Peter Angelo [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Cutler, Theresa Elizabeth [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Favalli, Andrea [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Koehler, Katrina Elizabeth [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Henzl, Vladimir [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Henzlova, Daniela [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Parker, Robert Francis [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Croft, Stephen [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2015-12-01

    In order to improve the accuracy and capabilities of neutron multiplicity counting, additional quantifiable information is needed in order to address the assumptions that are present in the point model. Extracting and utilizing higher order moments (Quads and Pents) from the neutron pulse train represents the most direct way of extracting additional information from the measurement data to allow for an improved determination of the physical properties of the item of interest. The extraction of higher order moments from a neutron pulse train required the development of advanced dead time correction algorithms which could correct for dead time effects in all of the measurement moments in a self-consistent manner. In addition, advanced analysis algorithms have been developed to address specific assumptions that are made within the current analysis model, namely that all neutrons are created at a single point within the item of interest, and that all neutrons that are produced within an item are created with the same energy distribution. This report will discuss the current status of implementation and initial testing of the advanced dead time correction and analysis algorithms that have been developed in an attempt to utilize higher order moments to improve the capabilities of correlated neutron measurement techniques.

  11. ADX: A high Power Density, Advanced RF-Driven Divertor Test Tokamak for PMI studies

    Science.gov (United States)

    Whyte, Dennis; ADX Team

    2015-11-01

    The MIT PSFC and collaborators are proposing an advanced divertor experiment, ADX; a divertor test tokamak dedicated to address critical gaps in plasma-material interactions (PMI) science, and the world fusion research program, on the pathway to FNSF/DEMO. Basic ADX design features are motivated and discussed. In order to assess the widest range of advanced divertor concepts, a large fraction (>50%) of the toroidal field volume is purpose-built with innovative magnetic topology control and flexibility for assessing different surfaces, including liquids. ADX features high B-field (>6 Tesla) and high global power density (P/S ~ 1.5 MW/m2) in order to access the full range of parallel heat flux and divertor plasma pressures foreseen for reactors, while simultaneously assessing the effect of highly dissipative divertors on core plasma/pedestal. Various options for efficiently achieving high field are being assessed including the use of Alcator technology (cryogenic cooled copper) and high-temperature superconductors. The experimental platform would also explore advanced lower hybrid current drive and ion-cyclotron range of frequency actuators located at the high-field side; a location which is predicted to greatly reduce the PMI effects on the launcher while minimally perturbing the core plasma. The synergistic effects of high-field launchers with high total B on current and flow drive can thus be studied in reactor-relevant boundary plasmas.

  12. POC-scale testing of an advanced fine coal dewatering equipment/technique

    Energy Technology Data Exchange (ETDEWEB)

    Groppo, J.G.; Parekh, B.K. [Univ. of Kentucky, Lexington, KY (United States); Rawls, P. [Department of Energy, Pittsburgh, PA (United States)

    1995-11-01

    Froth flotation technique is an effective and efficient process for recovering of ultra-fine (minus 74 {mu}m) clean coal. Economical dewatering of an ultra-fine clean coal product to a 20 percent level moisture will be an important step in successful implementation of the advanced cleaning processes. This project is a step in the Department of Energy`s program to show that ultra-clean coal could be effectively dewatered to 20 percent or lower moisture using either conventional or advanced dewatering techniques. As the contract title suggests, the main focus of the program is on proof-of-concept testing of a dewatering technique for a fine clean coal product. The coal industry is reluctant to use the advanced fine coal recovery technology due to the non-availability of an economical dewatering process. in fact, in a recent survey conducted by U.S. DOE and Battelle, dewatering of fine clean coal was identified as the number one priority for the coal industry. This project will attempt to demonstrate an efficient and economic fine clean coal slurry dewatering process.

  13. The use of ATR-FTIR imaging to study coated oil capsules

    NARCIS (Netherlands)

    Heussen, P.C.M.; Dalen, van G.; Nootenboom, P.; Smit, I.; Duynhoven, van J.P.M.

    2012-01-01

    Fourier transform infrared (FTIR) spectroscopic imaging using a large Internal Reflection Element (IRE), also called Attenuated Total Reflection (ATR) crystal, can be used for the identification and localisation of chemical compounds in solid food products. In this study ATR-FTIR imaging, by means o

  14. ATR-FTIR Spectroscopy in the Undergraduate Chemistry Laboratory: Part I--Fundamentals and Examples

    Science.gov (United States)

    Schuttlefield, Jennifer D.; Grassian, Vicki H.

    2008-01-01

    Attenuated total reflectance-Fourier transform infrared (ATR-FTIR) spectroscopy is a useful technique for measuring the infrared spectra of solids and liquids as well as probing adsorption on particle surfaces. Several examples of the use of FTIR-ATR spectroscopy in different undergraduate chemistry laboratory courses are presented here. These…

  15. ATR-FTIR Spectroscopy in the Undergraduate Chemistry Laboratory: Part I--Fundamentals and Examples

    Science.gov (United States)

    Schuttlefield, Jennifer D.; Grassian, Vicki H.

    2008-01-01

    Attenuated total reflectance-Fourier transform infrared (ATR-FTIR) spectroscopy is a useful technique for measuring the infrared spectra of solids and liquids as well as probing adsorption on particle surfaces. Several examples of the use of FTIR-ATR spectroscopy in different undergraduate chemistry laboratory courses are presented here. These…

  16. ATR acts stage specifically to regulate multiple aspects of mammalian meiotic silencing.

    Science.gov (United States)

    Royo, Hélène; Prosser, Haydn; Ruzankina, Yaroslava; Mahadevaiah, Shantha K; Cloutier, Jeffrey M; Baumann, Marek; Fukuda, Tomoyuki; Höög, Christer; Tóth, Attila; de Rooij, Dirk G; Bradley, Allan; Brown, Eric J; Turner, James M A

    2013-07-01

    In mammals, homologs that fail to synapse during meiosis are transcriptionally inactivated. This process, meiotic silencing, drives inactivation of the heterologous XY bivalent in male germ cells (meiotic sex chromosome inactivation [MSCI]) and is thought to act as a meiotic surveillance mechanism. The checkpoint protein ATM and Rad3-related (ATR) localizes to unsynapsed chromosomes, but its role in the initiation and maintenance of meiotic silencing is unknown. Here we show that ATR has multiple roles in silencing. ATR first regulates HORMA (Hop1, Rev7, and Mad2) domain protein HORMAD1/2 phosphorylation and localization of breast cancer I (BRCA1) and ATR cofactors ATR-interacting peptide (ATRIP)/topoisomerase 2-binding protein 1 (TOPBP1) at unsynapsed axes. Later, it acts as an adaptor, transducing signaling at unsynapsed axes into surrounding chromatin in a manner that requires interdependence with mediator of DNA damage checkpoint 1 (MDC1) and H2AFX. Finally, ATR catalyzes histone H2AFX phosphorylation, the epigenetic event leading to gene inactivation. Using a novel genetic strategy in which MSCI is used to silence a chosen gene in pachytene, we show that ATR depletion does not disrupt the maintenance of silencing and that silencing comprises two phases: The first is dynamic and reversible, and the second is stable and irreversible. Our work identifies a role for ATR in the epigenetic regulation of gene expression and presents a new technique for ablating gene function in the germline.

  17. Partial duplications of the ATRX gene cause the ATR-X syndrome.

    Science.gov (United States)

    Thienpont, Bernard; de Ravel, Thomy; Van Esch, Hilde; Van Schoubroeck, Dominique; Moerman, Philippe; Vermeesch, Joris Robert; Fryns, Jean-Pierre; Froyen, Guy; Lacoste, Caroline; Badens, Catherine; Devriendt, Koen

    2007-10-01

    ATR-X syndrome is a rare syndromic X-linked mental retardation disorder. We report that some of the patients suspected of ATR-X carry large intragenic duplications in the ATRX gene, leading to an absence of ATRX mRNA and of the protein. These findings underscore the need for including quantitative analyses to mutation analysis of the ATRX gene.

  18. Mislocalization of the MRN complex prevents ATR signaling during adenovirus infection

    DEFF Research Database (Denmark)

    Carson, Christian T; Orazio, Nicole I; Lee, Darwin V

    2009-01-01

    The protein kinases ataxia-telangiectasia mutated (ATM) and ATM-Rad3 related (ATR) are activated in response to DNA damage, genotoxic stress and virus infections. Here we show that during infection with wild-type adenovirus, ATR and its cofactors RPA32, ATRIP and TopBP1 accumulate at viral...

  19. Assessing advanced locomotor recovery after total hip arthroplasty with the timed stair test.

    Science.gov (United States)

    Perron, Marc; Malouin, Francine; Moffet, Hélène

    2003-11-01

    To assess advanced locomotor performance with the timed stair test (TST) and to determine if the level of performance of a group of women one year after hip replacement changed with the functional demands of the tasks. Comparison of the performance of two groups of women. General community. A convenient sample including 18 women who had had a total hip replacement 11 months earlier (patients) and 15 healthy age-matched women (comparison group). Three tests were administered: the 10-m walk test, the unloaded TST and the loaded TST (10 kg). The duration of each test was recorded and transformed into speed and the level of performance was assessed by calculating percentage deficit using corresponding values from the comparison group. The TST is made of four subtasks: (1) standing up and walking, (2) ascending stairs, (3) turning and descending stairs, (4) walking back, turning and sitting down. Significant differences in performance were found for all three tests with the patients showing a slower performance. The percentage deficits increased significantly from the less difficult (walking: 18%) to the more difficult conditions (unloaded TST: 23% and loaded TST: 28%), with the greatest deficits found during stair descent. Strong correlations were also found between walking deficits and TST deficits (loaded: r = 0.82; unloaded: r = 0.88). By combining mobility, walking and stair activities, the TST can be used to assess various components of advanced locomotor performance. The progressive level of difficulty of the TST subtasks as well as the addition of a load make it useful to detect subtle locomotor disabilities.

  20. Identification and classification of textile fibres using ATR-FT-IR spectroscopy with chemometric methods.

    Science.gov (United States)

    Peets, Pilleriin; Leito, Ivo; Pelt, Jaan; Vahur, Signe

    2017-02-15

    The possibility of classification of single- and two-component textile materials using ATR-FT-IR spectra and chemometric methods, principal component analysis (PCA) and discriminant analysis, was assessed. Altogether 89 textile samples belonging to 26 different types (11 one- and 15 two-component textiles) were investigated. It was found that PCA classification using only two or three principal components (PCs) enables identifying different one- and two-component textiles, although with two important limitations: it was not always possible to distinguish between the cellulose-based fibres (cotton, linen and in some cases viscose) and it was only partly possible to distinguish between silk and wool. The statistical discriminant analysis can use as many PCs as there are sample classes and due to that can discriminate between single-component fibres, including viscose from linen and cotton as well as silk from wool. Besides that, in both of these cases, involving optical microscopy as an additional technique enabled unequivocal identification of the fibres. The possibilities of semi-quantitative analysis of mixed fibres (cotton-polyester, wool-polyester and wool-polyamide) with PCA were investigated and it was found that approximate quantitative composition is obtainable if for the mixed fibre sample a number of spectra are averaged in order to minimize the effect of structural inhomogeneity. For approximate content determination 25 spectra of selected two-component samples were registered for calibration and the averaged spectrum for each sample was computed. Due to the structural inhomogeneity of mixed textiles, obtaining accurate quantitative composition from real samples is not possible with ATR-FT-IR. The main problems with ATR-FT-IR-PCA classification are (1) difficulties in getting high quality spectra from some textiles (e.g. polyacrylic), (2) inhomogeneity of the textile fibres in the case of two-component fibres and (3) intrinsic similarity between the

  1. Identification and classification of textile fibres using ATR-FT-IR spectroscopy with chemometric methods

    Science.gov (United States)

    Peets, Pilleriin; Leito, Ivo; Pelt, Jaan; Vahur, Signe

    2017-02-01

    The possibility of classification of single- and two-component textile materials using ATR-FT-IR spectra and chemometric methods, principal component analysis (PCA) and discriminant analysis, was assessed. Altogether 89 textile samples belonging to 26 different types (11 one- and 15 two-component textiles) were investigated. It was found that PCA classification using only two or three principal components (PCs) enables identifying different one- and two-component textiles, although with two important limitations: it was not always possible to distinguish between the cellulose-based fibres (cotton, linen and in some cases viscose) and it was only partly possible to distinguish between silk and wool. The statistical discriminant analysis can use as many PCs as there are sample classes and due to that can discriminate between single-component fibres, including viscose from linen and cotton as well as silk from wool. Besides that, in both of these cases, involving optical microscopy as an additional technique enabled unequivocal identification of the fibres. The possibilities of semi-quantitative analysis of mixed fibres (cotton-polyester, wool-polyester and wool-polyamide) with PCA were investigated and it was found that approximate quantitative composition is obtainable if for the mixed fibre sample a number of spectra are averaged in order to minimize the effect of structural inhomogeneity. For approximate content determination 25 spectra of selected two-component samples were registered for calibration and the averaged spectrum for each sample was computed. Due to the structural inhomogeneity of mixed textiles, obtaining accurate quantitative composition from real samples is not possible with ATR-FT-IR. The main problems with ATR-FT-IR-PCA classification are (1) difficulties in getting high quality spectra from some textiles (e.g. polyacrylic), (2) inhomogeneity of the textile fibres in the case of two-component fibres and (3) intrinsic similarity between the

  2. Summary of thermocouple performance during advanced gas reactor fuel irradiation experiments in the advanced test reactor and out-of-pile thermocouple testing in support of such experiments

    Energy Technology Data Exchange (ETDEWEB)

    Palmer, A. J.; Haggard, DC; Herter, J. W.; Swank, W. D.; Knudson, D. L.; Cherry, R. S. [Idaho National Laboratory, P.O. Box 1625, MS 4112, Idaho Falls, ID, (United States); Scervini, M. [University of Cambridge, Department of Material Science and Metallurgy, 27 Charles Babbage Road, CB3 0FS, Cambridge, (United Kingdom)

    2015-07-01

    High temperature gas reactor experiments create unique challenges for thermocouple-based temperature measurements. As a result of the interaction with neutrons, the thermoelements of the thermocouples undergo transmutation, which produces a time-dependent change in composition and, as a consequence, a time-dependent drift of the thermocouple signal. This drift is particularly severe for high temperature platinum-rhodium thermocouples (Types S, R, and B) and tungsten-rhenium thermocouples (Type C). For lower temperature applications, previous experiences with Type K thermocouples in nuclear reactors have shown that they are affected by neutron irradiation only to a limited extent. Similarly, Type N thermocouples are expected to be only slightly affected by neutron fluence. Currently, the use of these nickel-based thermocouples is limited when the temperature exceeds 1000 deg. C due to drift related to phenomena other than nuclear irradiation. High rates of open-circuit failure are also typical. Over the past 10 years, three long-term Advanced Gas Reactor experiments have been conducted with measured temperatures ranging from 700 deg. C - 1200 deg. C. A variety of standard Type N and specialty thermocouple designs have been used in these experiments with mixed results. A brief summary of thermocouple performance in these experiments is provided. Most recently, out-of-pile testing has been conducted on a variety of Type N thermocouple designs at the following (nominal) temperatures and durations: 1150 deg. C and 1200 deg. C for 2,000 hours at each temperature, followed by 200 hours at 1250 deg. C and 200 hours at 1300 deg. C. The standard Type N design utilizes high purity, crushed MgO insulation and an Inconel 600 sheath. Several variations on the standard Type N design were tested, including a Haynes 214 alloy sheath, spinel (MgAl{sub 2}O{sub 4}) insulation instead of MgO, a customized sheath developed at the University of Cambridge, and finally a loose assembly

  3. Summary of Thermocouple Performance During Advanced Gas Reactor Fuel Irradiation Experiments in the Advanced Test Reactor and Out-of-Pile Thermocouple Testing in Support of Such Experiments

    Energy Technology Data Exchange (ETDEWEB)

    A. J. Palmer; DC Haggard; J. W. Herter; M. Scervini; W. D. Swank; D. L. Knudson; R. S. Cherry

    2011-07-01

    High temperature gas reactor experiments create unique challenges for thermocouple based temperature measurements. As a result of the interaction with neutrons, the thermoelements of the thermocouples undergo transmutation, which produces a time dependent change in composition and, as a consequence, a time dependent drift of the thermocouple signal. This drift is particularly severe for high temperature platinum-rhodium thermocouples (Types S, R, and B); and tungsten-rhenium thermocouples (Types C and W). For lower temperature applications, previous experiences with type K thermocouples in nuclear reactors have shown that they are affected by neutron irradiation only to a limited extent. Similarly type N thermocouples are expected to be only slightly affected by neutron fluxes. Currently the use of these Nickel based thermocouples is limited when the temperature exceeds 1000°C due to drift related to phenomena other than nuclear irradiation. High rates of open-circuit failure are also typical. Over the past ten years, three long-term Advanced Gas Reactor (AGR) experiments have been conducted with measured temperatures ranging from 700oC – 1200oC. A variety of standard Type N and specialty thermocouple designs have been used in these experiments with mixed results. A brief summary of thermocouple performance in these experiments is provided. Most recently, out of pile testing has been conducted on a variety of Type N thermocouple designs at the following (nominal) temperatures and durations: 1150oC and 1200oC for 2000 hours at each temperature, followed by 200 hours at 1250oC, and 200 hours at 1300oC. The standard Type N design utilizes high purity crushed MgO insulation and an Inconel 600 sheath. Several variations on the standard Type N design were tested, including Haynes 214 alloy sheath, spinel (MgAl2O4) insulation instead of MgO, a customized sheath developed at the University of Cambridge, and finally a loose assembly thermocouple with hard fired alumina

  4. High Current ESD Test of Advanced Triple Junction Solar Array Coupon

    Science.gov (United States)

    Wright, Kenneth H., Jr.; Schneider, Todd A.; Vaughn, Jason A.; Hoang, Bao; Wong, Frankie

    2015-01-01

    A test was conducted on an Advanced Triple Junction (ATJ) coupon that was part of a risk reduction effort in the development of a high-powered solar array design by SSL. The ATJ coupon was a small, 4-cell, two-string configuration that has served as the basic test coupon design used in previous SSL environmental aging campaigns. The coupon has many attributes of the flight design; e.g., substrate structure with graphite face sheets, integrated by-pass diodes, cell interconnects, RTV grout, wire routing, etc. The objective of the present test was to evaluate the performance of the coupon after being subjected to induced electrostatic discharge testing at two string voltages (100 V, 150 V) and four array current (1.65 A, 2.0 A, 2.475 A, and 3.3 A). An ESD test circuit, unique to SSL solar array design, was built that simulates the effect of missing cells and strings in a full solar panel with special primary arc flashover circuitry. A total of 73 primary arcs were obtained that included 7 temporary sustained arcs (TSA) events. The durations of the TSAs ranged from 50 micros to 2.9 ms. All TSAs occurred at a string voltage of 150 V. Post-test Large Area Pulsed Solar Simulator (LAPSS), Dark I-V, and By-Pass Diode tests showed that no degradation occurred due to the TSA events. In addition, the post-test insulation resistance measured was > 50 G-ohms between cells and substrate. These test results indicate a robust design for application to a high-current, high-power mission application.

  5. A feasibility study to determine cooling time and burnup of ATR fuel using a nondestructive technique and three types of gamma-ray detectors

    Energy Technology Data Exchange (ETDEWEB)

    Navarro, J.; Aryaeinejad, R.; Nigg, D.W. [Idaho National Laboratory, P. O. Box 1625, Idaho Falls, ID 83415 (United States)

    2011-07-01

    The goal of this work was to perform a feasibility study and establish measurement techniques to determine the burnup of the Advanced Test Reactor (ATR) fuels at the Idaho National Laboratory (INL). Three different detectors of high purity germanium (HPGe), lanthanum bromide (LaBr{sub 3}), and high pressure xenon (HPXe) in two detection system configurations of below and above the water pool were used in this study. The last two detectors were used for the first time in fuel burnup measurements. The results showed that a better quality spectra can be achieved with the above the water pool configuration. Both short and long cooling time fuels were investigated in order to determine which measurement technique, absolute or fission product ratio, is better suited in each scenario and also to establish what type of detector should be used in each case for the best burnup measurement. The burnup and cooling time calibrations were established using experimental absolute activities or isotopic ratios and ORIGEN burnup calculations. A method was developed to do burnup and cooling time calibrations using fission isotopes activities without the need to know the exact geometry. (authors)

  6. Evaluation of Erosion of the Dummy “EE” Plate 19 in YA Type ATR Fuel Element During Reactor PALM Cycles

    Energy Technology Data Exchange (ETDEWEB)

    Brower, Jeffrey O. [Idaho National Lab. (INL), Idaho Falls, ID (United States). Advanced Test Reactor; Glazoff, Michael V. [Idaho National Lab. (INL), Idaho Falls, ID (United States). Advanced Test Reactor; Eiden, Thomas J. [Idaho National Lab. (INL), Idaho Falls, ID (United States). Advanced Test Reactor; Rezvoi, Aleksey V. [Idaho National Lab. (INL), Idaho Falls, ID (United States). Advanced Test Reactor

    2016-08-01

    Advanced Test Reactor (ATR) Cycle 153B-1 was a 14-day, high-power, powered axial locator mechanism (PALM) operating cycle that completed on April 12, 2013. Cycle 153B-1 was a typical operating cycle for the ATR and did not result in any unusual plant transients. ATR was started up and shut down as scheduled. The PALM drive physically moves the selected experiments into and out of the core to simulate reactor startup and heat up, and shutdown and cooldown transients, while the reactor remains in steady state conditions. However, after the cycle was over, when the fuel elements were removed from the core and inspected, several thousand flow-assisted erosion pits and “horseshoeing” defects were readily observed on the surface of the several YA-type fuel elements (these are aluminum “dummy” plates that contain no fuel). In order to understand these erosion phenomena a thermal-hydraulic model of coolant channel 20 on a YA-M fuel element was generated. The boundaries of the model were the aluminum EE plate of a YA-M fuel element and a beryllium reflector block with 13 horizontal saw cuts which represented regions of zero flow. The heat generated in fuel plates 1 through 18 was modeled to be passing through the aluminum EE plate. The coolant channel 20 width was set at 0.058 in. (58 mils). It was established that the horizontal saw cuts had a significant effect on the temperature of the coolant. The flow, which was expected to vary linearly with gradual heating of the coolant as it passed through the channel, was extremely turbulent. The temperature rise, which was expected to be a smooth “S” curve, was represented by a series temperature rise “humps,” which occurred at each horizontal saw cut in the beryllium reflector block. Each of the 13 saw cuts had a chamfered edge which resulted in the coolant flow being re-directed as a jet across the coolant channel into the surface of the EE plate, which explained the temperature rise and the observed scalloping

  7. Advanced laboratory for testing plasma thrusters and Hall thruster measurement campaign

    Directory of Open Access Journals (Sweden)

    Szelecka Agnieszka

    2016-06-01

    Full Text Available Plasma engines are used for space propulsion as an alternative to chemical thrusters. Due to the high exhaust velocity of the propellant, they are more efficient for long-distance interplanetary space missions than their conventional counterparts. An advanced laboratory of plasma space propulsion (PlaNS at the Institute of Plasma Physics and Laser Microfusion (IPPLM specializes in designing and testing various electric propulsion devices. Inside of a special vacuum chamber with three performance pumps, an environment similar to the one that prevails in space is created. An innovative Micro Pulsed Plasma Thruster (LμPPT with liquid propellant was built at the laboratory. Now it is used to test the second prototype of Hall effect thruster (HET operating on krypton propellant. Meantime, an improved prototype of krypton Hall thruster is constructed.

  8. Analysis, fabrication, and field test of an advanced embedded throwing electromechanical sensing system

    Energy Technology Data Exchange (ETDEWEB)

    Gao, Zhen; Zhang, Dan [Beijing JiaoTong University, Beijing (China)

    2014-01-15

    Scientific measuring equipment is important in maintaining and further improving the daily training quality of professional athletes. In throwing sports, only kinematic information is usually recorded by several high-speed cameras, whereas the dynamic data are lacking. An advanced embedded throwing system is analyzed, fabricated, and field tested. This throwing system can be used to substitute the normal shot-put that obtains acceleration information from the upper limb when force is applied onto the device. This device has four main parts, namely, a mechanical shell, an embedded sensor, a signal processing circuit, and interface ports. The detailed design, simulation, and prototyping process are introduced in this work. The practical results obtained from the field test and feedback from users prove that the proposed throwing system is efficient for technical training and monitoring. This design provides a unique solution for the modeling and development of non-traditional, electro-mechanical sensing devices.

  9. Advanced thermal energy management: A thermal test bed and heat pipe simulation

    Science.gov (United States)

    Barile, Ronald G.

    1986-01-01

    Work initiated on a common-module thermal test simulation was continued, and a second project on heat pipe simulation was begun. The test bed, constructed from surplus Skylab equipment, was modeled and solved for various thermal load and flow conditions. Low thermal load caused the radiator fluid, Coolanol 25, to thicken due to its temperature avoided by using a regenerator-heat-exchanger. Other possible solutions modeled include a radiator heater and shunting heat from the central thermal bus to the radiator. Also, module air temperature can become excessive with high avionics load. A second preoject concerning advanced heat pipe concepts was initiated. A program was written which calculates fluid physical properties, liquid and vapor pressure in the evaporator and condenser, fluid flow rates, and thermal flux. The program is directed to evaluating newer heat pipe wicks and geometries, especially water in an artery surrounded by six vapor channels. Effects of temperature, groove and slot dimensions, and wick properties are reported.

  10. Lateral noise attenuation of the advanced propeller of the propfan test assessment aircraft

    Science.gov (United States)

    Chambers, F. W.; Reddy, N. N.; Bartel, H. W.

    1989-01-01

    Lateral noise attenuation characteristics of the advanced propeller are determined using the flight test results of the testbed aircraft, Propfan Test Assessment (PTA), with a single, large-scale propfan. The acoustic data were obtained with an array of ground-mounted microphones positioned at distances up to 2.47 km (8100 feet) to the side of the flight path. The aircraft was flown at a Mach number of 0.31 for a variety of operating conditions. The lateral noise attenuation in a frequency range containing the blade passage frequency of the propeller was found to have positive magnitudes on the propfan side and negative magnitudes on the opposite side. The measured attenuation exhibits a strong dependence upon the elevation angle. The results also display a clear dependence upon the angle at which the propeller and nacelle are mounted on the wing (inflow angle).

  11. Development and proof-testing of advanced absorption refrigeration cycle concepts

    Energy Technology Data Exchange (ETDEWEB)

    Modahl, R.J.; Hayes, F.C. (Trane Co., La Crosse, WI (United States). Applied Unitary/Refrigeration Systems Div.)

    1992-03-01

    The overall objectives of this project are to evaluate, develop, and proof-test advanced absorption refrigeration cycles that are applicable to residential and commercial heat pumps for space conditioning. The heat pump system is to be direct-fired with natural gas and is to use absorption working fluids whose properties are known. Target coefficients of performance (COPs) are 1.6 at 47{degrees}F and 1.2 at 17{degrees} in the heating mode, and 0.7 at 95{degree}F in the cooling mode, including the effect of flue losses. The project is divided into three phases. Phase I entailed the analytical evaluation of advanced cycles and included the selection of preferred concepts for further development. Phase II involves the development and testing of critical components and of a complete laboratory breadboard version of the selected system. Phase III calls for the development of a prototype unit and is contingent on the successful completion of Phase II. This report covers Phase I work on the project. In Phase 1, 24 advanced absorption cycle/fluid combinations were evaluated, and computer models were developed to predict system performance. COP, theoretical pump power, and internal heat exchange were calculated for each system, and these calculations were used as indicators of operating and installed costs in order to rank the relative promise of each system. The highest ranking systems involve the cycle concept of absorber/generator heat exchange, generator heat exchanger/absorber heat exchange, regeneration, and resorption/desorption, in combination with the NH{sub 3}/H{sub 2}O/LiBr ternary absorption fluid mixture or with the NH{sub 3}/H{sub 2}O binary solution. Based upon these conclusions, the recommendation was made to proceed to Phase II, the laboratory breadboard proof-of- concept.

  12. The Continued Need for Modeling and Scaled Testing to Advance the Hanford Tank Waste Mission

    Energy Technology Data Exchange (ETDEWEB)

    Peurrung, Loni M.; Fort, James A.; Rector, David R.

    2013-09-03

    Hanford tank wastes are chemically complex slurries of liquids and solids that can exhibit changes in rheological behavior during retrieval and processing. The Hanford Waste Treatment and Immobilization Plant (WTP) recently abandoned its planned approach to use computational fluid dynamics (CFD) supported by testing at less than full scale to verify the design of vessels that process these wastes within the plant. The commercial CFD tool selected was deemed too difficult to validate to the degree necessary for use in the design of a nuclear facility. Alternative, but somewhat immature, CFD tools are available that can simulate multiphase flow of non-Newtonian fluids. Yet both CFD and scaled testing can play an important role in advancing the Hanford tank waste mission—in supporting the new verification approach, which is to conduct testing in actual plant vessels; in supporting waste feed delivery, where scaled testing is ongoing; as a fallback approach to design verification if the Full Scale Vessel Testing Program is deemed too costly and time-consuming; to troubleshoot problems during commissioning and operation of the plant; and to evaluate the effects of any proposed changes in operating conditions in the future to optimize plant performance.

  13. Test Mass Temperature Field and Laser Aberration Modeling in Advanced LIGO

    Science.gov (United States)

    Ramette, Joshua; Kasprzack, Marie; Gonzalez, Gabriela; Brooks, Aidan; Blair, Carl; Kandhasamy, Shivaraj; Wang, Haoyu; LIGO Collaboration

    2017-01-01

    Advanced LIGO uses high laser power in the main interferometer arm cavities to achieve design sensitivity. A small part of this power is absorbed in the interferometer cavity mirrors where it creates thermal lenses. Actuation by ``ring heaters,'' additional heater elements aimed to reduce the temperature gradients in the mirrors, minimizes aberrations in the main laser beam due to thermal lensing. We derive the first analytical model of the temperature field contribution in the mirrors generated by an ideal ring heater. In addition, we simulate the test mass temperature field using finite element analysis software and find agreement with the prediction of our ring heater analytical model and existing models for self-heating of the test mass by the main laser beam. From our ring heater temperature field models, we then express the resulting optical aberration contribution in the main laser and compare to Hartmann wavefront sensor measurements of the aberration. Used in conjunction with wavefront measurements, our model provides a more complete understanding of the thermal state of the cavity mirrors and will allow a more efficient use of the ring heaters in Advanced LIGO. We thank the National Science Foundation for supporting this work (NSF grant #1262890 and #1205882).

  14. Critical need for MFE: the Alcator DX advanced divertor test facility

    Science.gov (United States)

    Vieira, R.; Labombard, B.; Marmar, E.; Irby, J.; Wolf, S.; Bonoli, P.; Fiore, C.; Granetz, R.; Greenwald, M.; Hutchinson, I.; Hubbard, A.; Hughes, J.; Lin, Y.; Lipschultz, B.; Parker, R.; Porkolab, M.; Reinke, M.; Rice, J.; Shiraiwa, S.; Terry, J.; Theiler, C.; Wallace, G.; White, A.; Whyte, D.; Wukitch, S.

    2013-10-01

    Three critical challenges must be met before a steady-state, power-producing fusion reactor can be realized: how to (1) safely handle extreme plasma exhaust power, (2) completely suppress material erosion at divertor targets and (3) do this while maintaining a burning plasma core. Advanced divertors such as ``Super X'' and ``X-point target'' may allow a fully detached, low temperature plasma to be produced in the divertor while maintaining a hot boundary layer around a clean plasma core - a potential game-changer for magnetic fusion. No facility currently exists to test these ideas at the required parallel heat flux densities. Alcator DX will be a national facility, employing the high magnetic field technology of Alcator combined with high-power ICRH and LHCD to test advanced divertor concepts at FNSF/DEMO power exhaust densities and plasma pressures. Its extended vacuum vessel contains divertor cassettes with poloidal field coils for conventional, snowflake, super-X and X-point target geometries. Divertor and core plasma performance will be explored in regimes inaccessible in conventional devices. Reactor relevant ICRF and LH drivers will be developed, utilizing high-field side launch platforms for low PMI. Alcator DX will inform the conceptual development and accelerate the readiness-for-deployment of next-step fusion facilities.

  15. Advanced digital speckle correlation method for strain measurement and nondestructive testing

    Science.gov (United States)

    Jin, Guan-chang; Bao, Nai-Keng; Chung, Po Sheun

    1997-03-01

    An advanced digital speckle correlation method (DSCM) is presented in this paper. The advantages of this method will not only improve the processing speed but also increase the measuring accuracy. Some mathematics tools are derived and a powerful computing program is developed for further applications. A new feature of the measuring sensitivity of DSCM that can be varied by different amplification of the optical arrangement is first presented. This advantage may be superior to those available in other optical metrology methods like Electronic Speckle Pattern Interferometry (ESPI) in micro-deformation measurements. The applications of strain measurement and nondestructive testing are described and the advantages of DSCM are obvious. Some examples of material behavior measurement and plastic strain measurement are presented. Due to the high sensitivity of DSCM, another potential application in nondestructive testing (NDT) is also described in this paper. From the application examples given, this advanced DSCM proves to be a new and effective optical strain sensing technique especially for small objects or micro-deformation measurements.

  16. ADX: a high field, high power density, Advanced Divertor test eXperiment

    Science.gov (United States)

    Vieira, R.; Labombard, B.; Marmar, E.; Irby, J.; Shiraiwa, S.; Terry, J.; Wallace, G.; Whyte, D. G.; Wolfe, S.; Wukitch, S.; ADX Team

    2014-10-01

    The MIT PSFC and collaborators are proposing an advanced divertor experiment (ADX) - a tokamak specifically designed to address critical gaps in the world fusion research program on the pathway to FNSF/DEMO. This high field (6.5 tesla, 1.5 MA), high power density (P/S ~ 1.5 MW/m2) facility would utilize Alcator magnet technology to test innovative divertor concepts for next-step DT fusion devices (FNSF, DEMO) at reactor-level boundary plasma pressures and parallel heat flux densities while producing high performance core plasma conditions. The experimental platform would also test advanced lower hybrid current drive (LHCD) and ion-cyclotron range of frequency (ICRF) actuators and wave physics at the plasma densities and magnetic field strengths of a DEMO, with the unique ability to deploy launcher structures both on the low-magnetic-field side and the high-field side - a location where energetic plasma-material interactions can be controlled and wave physics is most favorable for efficient current drive, heating and flow drive. This innovative experiment would perform plasma science and technology R&D necessary to inform the conceptual development and accelerate the readiness-for-deployment of FNSF/DEMO - in a timely manner, on a cost-effective research platform. Supported by DE-FC02-99ER54512.

  17. Test Platform for Advanced Digital Control of Brushless DC Motors (MSFC Center Director's Discretionary Fund)

    Science.gov (United States)

    Gwaltney, D. A.

    2002-01-01

    A FY 2001 Center Director's Discretionary Fund task to develop a test platform for the development, implementation. and evaluation of adaptive and other advanced control techniques for brushless DC (BLDC) motor-driven mechanisms is described. Important applications for BLDC motor-driven mechanisms are the translation of specimens in microgravity experiments and electromechanical actuation of nozzle and fuel valves in propulsion systems. Motor-driven aerocontrol surfaces are also being utilized in developmental X vehicles. The experimental test platform employs a linear translation stage that is mounted vertically and driven by a BLDC motor. Control approaches are implemented on a digital signal processor-based controller for real-time, closed-loop control of the stage carriage position. The goal of the effort is to explore the application of advanced control approaches that can enhance the performance of a motor-driven actuator over the performance obtained using linear control approaches with fixed gains. Adaptive controllers utilizing an exact model knowledge controller and a self-tuning controller are implemented and the control system performance is illustrated through the presentation of experimental results.

  18. Evaluation, engineering and development of advanced cyclone processes. Final separating media evaluation and test report (FSMER). Appendices

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-05-01

    This report consists of appendices pertaining to the separating media evaluation (calcium nitrate solution) and testing for an advanced cyclone process. Appendices include: materials safety data, aqueous medium regeneration, pH control strategy, and other notes and data.

  19. ADVANCED UTILITY SIMULATION MODEL, REPORT OF SENSITIVITY TESTING, CALIBRATION, AND MODEL OUTPUT COMPARISONS (VERSION 3.0)

    Science.gov (United States)

    The report gives results of activities relating to the Advanced Utility Simulation Model (AUSM): sensitivity testing. comparison with a mature electric utility model, and calibration to historical emissions. The activities were aimed at demonstrating AUSM's validity over input va...

  20. Structural Analysis of Spiropyran Polimers using ATR Spectroscopy

    Energy Technology Data Exchange (ETDEWEB)

    Delgado Macui, R; Rojas Lopez, M; Gayou, V L; Orduna Diaz, A [Centro de Investigacion en BiotecnologIa Aplicada del IPN, San Juan de los Molinos km. 1.5 Tepetitla de Lardizabal, A.P. 90700, Tlaxcala (Mexico)

    2006-01-01

    We have used infrared spectroscopy in attenuated total reflection (ATR) mode to analyze the interactions between the polymeric base and solvent with a photochromic material (spyropiran). We used cellulose acetate as polymeric base and the spyropiran; 1,3,3 trimethyl indoline-5-nitro benzopyrane. Thin films with different weight concentrations of SP were deposited in the polymeric base. The infrared spectra show bands whose frequencies are associated to several molecular bondings. It was observed a decreasing in intensity of absorbance for C = O stretching mode of the acetate group at 1720 cm{sup -1} and for C = C stretching mode for the main chain at 823 and 982 cm{sup -1} both associated to the presence of SP in polymeric films.

  1. Modern approaches in deep learning for SAR ATR

    Science.gov (United States)

    Wilmanski, Michael; Kreucher, Chris; Lauer, Jim

    2016-05-01

    Recent breakthroughs in computational capabilities and optimization algorithms have enabled a new class of signal processing approaches based on deep neural networks (DNNs). These algorithms have been extremely successful in the classification of natural images, audio, and text data. In particular, a special type of DNNs, called convolutional neural networks (CNNs) have recently shown superior performance for object recognition in image processing applications. This paper discusses modern training approaches adopted from the image processing literature and shows how those approaches enable significantly improved performance for synthetic aperture radar (SAR) automatic target recognition (ATR). In particular, we show how a set of novel enhancements to the learning algorithm, based on new stochastic gradient descent approaches, generate significant classification improvement over previously published results on a standard dataset called MSTAR.

  2. Wurfelspiel-based training data methods for ATR

    Science.gov (United States)

    Peterson, James K.

    2004-09-01

    A data object is constructed from a P by M Wurfelspiel matrix W by choosing an entry from each column to construct a sequence A0A1"AM-1. Each of the PM possibilities are designed to correspond to the same category according to some chosen measure. This matrix could encode many types of data. (1) Musical fragments, all of which evoke sadness; each column entry is a 4 beat sequence with a chosen A0A1A2 thus 16 beats long (W is P by 3). (2) Paintings, all of which evoke happiness; each column entry is a layer and a given A0A1A2 is a painting constructed using these layers (W is P by 3). (3) abstract feature vectors corresponding to action potentials evoked from a biological cell's exposure to a toxin. The action potential is divided into four relevant regions and each column entry represents the feature vector of a region. A given A0A1A2 is then an abstraction of the excitable cell's output (W is P by 4). (4) abstract feature vectors corresponding to an object such as a face or vehicle. The object is divided into four categories each assigned an abstract feature vector with the resulting concatenation an abstract representation of the object (W is P by 4). All of the examples above correspond to one particular measure (sad music, happy paintings, an introduced toxin, an object to recognize)and hence, when a Wurfelspiel matrix is constructed, relevant training information for recognition is encoded that can be used in many algorithms. The focus of this paper is on the application of these ideas to automatic target recognition (ATR). In addition, we discuss a larger biologically based model of temporal cortex polymodal sensor fusion which can use the feature vectors extracted from the ATR Wurfelspiel data.

  3. Advanced practice registered nurse usability testing of a tailored computer-mediated health communication program.

    Science.gov (United States)

    Lin, Carolyn A; Neafsey, Patricia J; Anderson, Elizabeth

    2010-01-01

    This study tested the usability of a touch-screen-enabled Personal Education Program with advanced practice RNs. The Personal Education Program is designed to enhance medication adherence and reduce adverse self-medication behaviors in older adults with hypertension. An iterative research process was used, which involved the use of (1) pretrial focus groups to guide the design of system information architecture, (2) two different cycles of think-aloud trials to test the software interface, and (3) post-trial focus groups to gather feedback on the think-aloud studies. Results from this iterative usability-testing process were used to systematically modify and improve the three Personal Education Program prototype versions-the pilot, prototype 1, and prototype 2. Findings contrasting the two separate think-aloud trials showed that APRN users rated the Personal Education Program system usability, system information, and system-use satisfaction at a moderately high level between trials. In addition, errors using the interface were reduced by 76%, and the interface time was reduced by 18.5% between the two trials. The usability-testing processes used in this study ensured an interface design adapted to APRNs' needs and preferences to allow them to effectively use the computer-mediated health-communication technology in a clinical setting.

  4. Enabling More than Moore: Accelerated Reliability Testing and Risk Analysis for Advanced Electronics Packaging

    Science.gov (United States)

    Ghaffarian, Reza; Evans, John W.

    2014-01-01

    For five decades, the semiconductor industry has distinguished itself by the rapid pace of improvement in miniaturization of electronics products-Moore's Law. Now, scaling hits a brick wall, a paradigm shift. The industry roadmaps recognized the scaling limitation and project that packaging technologies will meet further miniaturization needs or ak.a "More than Moore". This paper presents packaging technology trends and accelerated reliability testing methods currently being practiced. Then, it presents industry status on key advanced electronic packages, factors affecting accelerated solder joint reliability of area array packages, and IPC/JEDEC/Mil specifications for characterizations of assemblies under accelerated thermal and mechanical loading. Finally, it presents an examples demonstrating how Accelerated Testing and Analysis have been effectively employed in the development of complex spacecraft thereby reducing risk. Quantitative assessments necessarily involve the mathematics of probability and statistics. In addition, accelerated tests need to be designed which consider the desired risk posture and schedule for particular project. Such assessments relieve risks without imposing additional costs. and constraints that are not value added for a particular mission. Furthermore, in the course of development of complex systems, variances and defects will inevitably present themselves and require a decision concerning their disposition, necessitating quantitative assessments. In summary, this paper presents a comprehensive view point, from technology to systems, including the benefits and impact of accelerated testing in offsetting risk.

  5. Advanced spatio-temporal filtering techniques for photogrammetric image sequence analysis in civil engineering material testing

    Science.gov (United States)

    Liebold, F.; Maas, H.-G.

    2016-01-01

    The paper shows advanced spatial, temporal and spatio-temporal filtering techniques which may be used to reduce noise effects in photogrammetric image sequence analysis tasks and tools. As a practical example, the techniques are validated in a photogrammetric spatio-temporal crack detection and analysis tool applied in load tests in civil engineering material testing. The load test technique is based on monocular image sequences of a test object under varying load conditions. The first image of a sequence is defined as a reference image under zero load, wherein interest points are determined and connected in a triangular irregular network structure. For each epoch, these triangles are compared to the reference image triangles to search for deformations. The result of the feature point tracking and triangle comparison process is a spatio-temporally resolved strain value field, wherein cracks can be detected, located and measured via local discrepancies. The strains can be visualized as a color-coded map. In order to improve the measuring system and to reduce noise, the strain values of each triangle must be treated in a filtering process. The paper shows the results of various filter techniques in the spatial and in the temporal domain as well as spatio-temporal filtering techniques applied to these data. The best results were obtained by a bilateral filter in the spatial domain and by a spatio-temporal EOF (empirical orthogonal function) filtering technique.

  6. Post launch calibration and testing of the Advanced Baseline Imager on the GOES-R satellite

    Science.gov (United States)

    Lebair, William; Rollins, C.; Kline, John; Todirita, M.; Kronenwetter, J.

    2016-05-01

    The Geostationary Operational Environmental Satellite R (GOES-R) series is the planned next generation of operational weather satellites for the United State's National Oceanic and Atmospheric Administration. The first launch of the GOES-R series is planned for October 2016. The GOES-R series satellites and instruments are being developed by the National Aeronautics and Space Administration (NASA). One of the key instruments on the GOES-R series is the Advance Baseline Imager (ABI). The ABI is a multi-channel, visible through infrared, passive imaging radiometer. The ABI will provide moderate spatial and spectral resolution at high temporal and radiometric resolution to accurately monitor rapidly changing weather. Initial on-orbit calibration and performance characterization is crucial to establishing baseline used to maintain performance throughout mission life. A series of tests has been planned to establish the post launch performance and establish the parameters needed to process the data in the Ground Processing Algorithm. The large number of detectors for each channel required to provide the needed temporal coverage presents unique challenges for accurately calibrating ABI and minimizing striping. This paper discusses the planned tests to be performed on ABI over the six-month Post Launch Test period and the expected performance as it relates to ground tests.

  7. System-Level Testing of the Advanced Stirling Radioisotope Generator Engineering Hardware

    Science.gov (United States)

    Chan, Jack; Wiser, Jack; Brown, Greg; Florin, Dominic; Oriti, Salvatore M.

    2014-01-01

    To support future NASA deep space missions, a radioisotope power system utilizing Stirling power conversion technology was under development. This development effort was performed under the joint sponsorship of the Department of Energy and NASA, until its termination at the end of 2013 due to budget constraints. The higher conversion efficiency of the Stirling cycle compared with that of the Radioisotope Thermoelectric Generators (RTGs) used in previous missions (Viking, Pioneer, Voyager, Galileo, Ulysses, Cassini, Pluto New Horizons and Mars Science Laboratory) offers the advantage of a four-fold reduction in Pu-238 fuel, thereby extending its limited domestic supply. As part of closeout activities, system-level testing of flight-like Advanced Stirling Convertors (ASCs) with a flight-like ASC Controller Unit (ACU) was performed in February 2014. This hardware is the most representative of the flight design tested to date. The test fully demonstrates the following ACU and system functionality: system startup; ASC control and operation at nominal and worst-case operating conditions; power rectification; DC output power management throughout nominal and out-of-range host voltage levels; ACU fault management, and system command / telemetry via MIL-STD 1553 bus. This testing shows the viability of such a system for future deep space missions and bolsters confidence in the maturity of the flight design.

  8. Reactivity Initiated Accident Simulation to Inform Transient Testing of Candidate Advanced Cladding

    Energy Technology Data Exchange (ETDEWEB)

    Brown, Nicholas R [ORNL; Wysocki, Aaron J [ORNL; Terrani, Kurt A [ORNL

    2016-01-01

    Abstract. Advanced cladding materials with potentially enhanced accident tolerance will yield different light water reactor performance and safety characteristics than the present zirconium-based cladding alloys. These differences are due to different cladding material properties and responses to the transient, and to some extent, reactor physics, thermal, and hydraulic characteristics. Some of the differences in reactors physics characteristics will be driven by the fundamental properties (e.g., absorption in iron for an iron-based cladding) and others will be driven by design modifications necessitated by the candidate cladding materials (e.g., a larger fuel pellet to compensate for parasitic absorption). Potential changes in thermal hydraulic limits after transition from the current zirconium-based cladding to the advanced materials will also affect the transient response of the integral fuel. This paper leverages three-dimensional reactor core simulation capabilities to inform on appropriate experimental test conditions for candidate advanced cladding materials in a control rod ejection event. These test conditions are using three-dimensional nodal kinetics simulations of a reactivity initiated accident (RIA) in a representative state-of-the-art pressurized water reactor with both nuclear-grade iron-chromium-aluminum (FeCrAl) and silicon carbide based (SiC-SiC) cladding materials. The effort yields boundary conditions for experimental mechanical tests, specifically peak cladding strain during the power pulse following the rod ejection. The impact of candidate cladding materials on the reactor kinetics behavior of RIA progression versus reference zirconium cladding is predominantly due to differences in: (1) fuel mass/volume/specific power density, (2) spectral effects due to parasitic neutron absorption, (3) control rod worth due to hardened (or softened) spectrum, and (4) initial conditions due to power peaking and neutron transport cross sections in the

  9. Mutation of serine 1333 in the ATR HEAT repeats creates a hyperactive kinase.

    Directory of Open Access Journals (Sweden)

    Jessica W Luzwick

    Full Text Available Subcellular localization, protein interactions, and post-translational modifications regulate the DNA damage response kinases ATR, ATM, and DNA-PK. During an analysis of putative ATR phosphorylation sites, we found that a single mutation at S1333 creates a hyperactive kinase. In vitro and in cells, mutation of S1333 to alanine (S1333A-ATR causes elevated levels of kinase activity with and without the addition of the protein activator TOPBP1. S1333 mutations to glycine, arginine, or lysine also create a hyperactive kinase, while mutation to aspartic acid decreases ATR activity. S1333A-ATR maintains the G2 checkpoint and promotes completion of DNA replication after transient exposure to replication stress but the less active kinase, S1333D-ATR, has modest defects in both of these functions. While we find no evidence that S1333 is phosphorylated in cultured cells, our data indicate that small changes in the HEAT repeats can have large effects on kinase activity. These mutants may serve as useful tools for future studies of the ATR pathway.

  10. Field Testing LIDAR Based Feed-Forward Controls on the NREL Controls Advanced Research Turbine: Preprint

    Energy Technology Data Exchange (ETDEWEB)

    Scholbrock, A. K.; Fleming, P. A.; Fingersh, L. J.; Wright, A. D.; Schlipf, D.; Haizmann, F.; Belen, F.

    2013-01-01

    Wind turbines are complex, nonlinear, dynamic systems driven by aerodynamic, gravitational, centrifugal, and gyroscopic forces. The aerodynamics of wind turbines are nonlinear, unsteady, and complex. Turbine rotors are subjected to a chaotic three-dimensional (3-D) turbulent wind inflow field with imbedded coherent vortices that drive fatigue loads and reduce lifetime. In order to reduce cost of energy, future large multimegawatt turbines must be designed with lighter weight structures, using active controls to mitigate fatigue loads, maximize energy capture, and add active damping to maintain stability for these dynamically active structures operating in a complex environment. Researchers at the National Renewable Energy Laboratory (NREL) and University of Stuttgart are designing, implementing, and testing advanced feed-back and feed-forward controls in order to reduce the cost of energy for wind turbines.

  11. Capabilities Development for Transient Testing of Advanced Nuclear Fuels at TREAT

    Energy Technology Data Exchange (ETDEWEB)

    Woolstenhulme, N. E.; Baker, C. C.; Bess, J. D.; Davis, C. B.; Hill, C. M.; Housley, G. K.; Jensen, C. B.; Jerred, N. D.; O' Brien, R. C.; Snow, S. D.; Wachs, D. M.

    2016-09-01

    The TREAT facility is a unique capability at the Idaho National Laboratory currently being prepared for resumption of nuclear transient testing. Accordingly, designs for several transient irradiation tests are being pursued to enable development of advanced nuclear fuels and materials. In addition to the reactor itself, the foundation for TREAT’s capabilities also include a suite of irradiation vehicles and supporting infrastructure to provide the desired specimen boundary conditions while supporting a variety of instrumentation needs. The challenge of creating these vehicles, especially since many of the modern data needs were not historically addressed in TREAT experiment vehicles, has necessitated a sizeable engineering effort. This effort is currently underway and maturing rapidly. This paper summarizes the status, future plans, and rationale for TREAT experiment vehicle capabilities. Much of the current progress is focused around understanding and demonstrating the behavior of fuel design with enhanced accident tolerance in water-cooled reactors. Additionally, several related efforts are underway to facilitate transient testing in liquid sodium, inert gas, and steam environments. This paper discusses why such a variety of capabilities are needed, outlines plans to accomplish them, and describes the relationship between transient data needs and the irradiation hardware that will support the gathering of this information.

  12. Test-retest reliability of the Advanced Psychodiagnostic Interpretation (API) scoring system for the Bender Gestalt in chronic schizophrenics.

    Science.gov (United States)

    Aucone, E J; Wagner, E E; Raphael, A J; Golden, C J; Espe-Pfeifer, P; Dornheim, L; Seldon, J; Pospisil, T; Proctor-Weber, Z; Calabria, M

    2001-09-01

    This study assesses the test-retest reliability of the revised Advanced Psychodiagnostic Interpretation (API) scoring system for the Bender Gestalt Test (BGT). The API system identifies 207 possible distortions in a BGT protocol. Test-retest reliability for 40 schizophrenic patients tested twice with a mean interval of 6.4 years (SD=3.8 years) was good, ranging from .71 to .80. Further reliability and validity studies are needed to further demonstrate the effectiveness of the system.

  13. Cyclone Boiler Field Testing of Advanced Layered NOx Control Technology in Sioux Unit 1

    Energy Technology Data Exchange (ETDEWEB)

    Marc A. Cremer; Bradley R. Adams

    2006-06-30

    A four week testing program was completed during this project to assess the ability of the combination of deep staging, Rich Reagent Injection (RRI), and Selective Non-Catalytic Reduction (SNCR) to reduce NOx emissions below 0.15 lb/MBtu in a cyclone fired boiler. The host site for the tests was AmerenUE's Sioux Unit 1, a 500 MW cyclone fired boiler located near St. Louis, MO. Reaction Engineering International (REI) led the project team including AmerenUE, FuelTech Inc., and the Electric Power Research Institute (EPRI). This layered approach to NOx reduction is termed the Advanced Layered Technology Approach (ALTA). Installed RRI and SNCR port locations were guided by computational fluid dynamics (CFD) based modeling conducted by REI. During the parametric testing, NOx emissions of 0.12 lb/MBtu were achieved consistently from overfire air (OFA)-only baseline NOx emissions of 0.25 lb/MBtu or less, when firing the typical 80/20 fuel blend of Powder River Basin (PRB) and Illinois No.6 coals. From OFA-only baseline levels of 0.20 lb/MBtu, NOx emissions of 0.12 lb/MBtu were also achieved, but at significantly reduced urea flow rates. Under the deeply staged conditions that were tested, RRI performance was observed to degrade as higher blends of Illinois No.6 were used. NOx emissions achieved with ALTA while firing a 60/40 blend were approximately 0.15 lb/MBtu. NOx emissions while firing 100% Illinois No.6 were approximately 0.165 lb/MBtu. Based on the performance results of these tests, economics analyses of the application of ALTA to a nominal 500 MW cyclone unit show that the levelized cost to achieve 0.15 lb/MBtu is well below 75% of the cost of a state of the art SCR.

  14. Identification of a Novel System for Boron Transport: Atr1 Is a Main Boron Exporter in Yeast▿ †

    Science.gov (United States)

    Kaya, Alaattin; Karakaya, Huseyin C.; Fomenko, Dmitri E.; Gladyshev, Vadim N.; Koc, Ahmet

    2009-01-01

    Boron is a micronutrient in plants and animals, but its specific roles in cellular processes are not known. To understand boron transport and functions, we screened a yeast genomic DNA library for genes that confer resistance to the element in Saccharomyces cerevisiae. Thirty boron-resistant transformants were isolated, and they all contained the ATR1 (YML116w) gene. Atr1 is a multidrug resistance transport protein belonging to the major facilitator superfamily. C-terminal green fluorescent protein-tagged Atr1 localized to the cell membrane and vacuole, and ATR1 gene expression was upregulated by boron and several stress conditions. We found that atr1Δ mutants were highly sensitive to boron treatment, whereas cells overexpressing ATR1 were boron resistant. In addition, atr1Δ cells accumulated boron, whereas ATR1-overexpressing cells had low intracellular levels of the element. Furthermore, atr1Δ cells showed stronger boron-dependent phenotypes than mutants deficient in genes previously reported to be implicated in boron metabolism. ATR1 is widely distributed in bacteria, archaea, and lower eukaryotes. Our data suggest that Atr1 functions as a boron efflux pump and is required for boron tolerance. PMID:19414602

  15. High Pressure Burner Rig Testing of Advanced Environmental Barrier Coatings for Si3N4 Turbine Components

    Science.gov (United States)

    Zhu, Dongming; Fox, Dennis S.; Pastel, Robert T.

    2007-01-01

    Advanced thermal and environmental barrier coatings are being developed for Si3N4 components for turbine engine propulsion applications. High pressure burner rig testing was used to evaluate the coating system performance and durability. Test results demonstrated the feasibility and durability of the coating component systems under the simulated engine environments.

  16. Investigating the Photocatalytic Degradation of Oil Paint using ATR-IR and AFM-IR.

    Science.gov (United States)

    Morsch, Suzanne; van Driel, Birgit A; van den Berg, Klaas Jan; Dik, Joris

    2017-03-22

    As linseed oil has a longstanding and continuing history of use as a binder in artistic paints, developing an understanding of its degradation mechanism is critical to conservation efforts. At present, little can be done to detect the early stages of oil paint deterioration due to the complex chemical composition of degrading paints. In this work, we use advanced infrared analysis techniques to investigate the UV-induced deterioration of model linseed oil paints in detail. Subdiffraction limit infrared analysis (AFM-IR) is applied to identify and map accelerated degradation in the presence of two different grades of titanium white pigment particles (rutile or anatase TiO2). Differentiation between the degradation of these two formulations demonstrates the sensitivity of this approach. The identification of characteristic peaks and transient species residing at the paint surface allows infrared absorbance peaks related to degradation deeper in the film to be extricated from conventional ATR-FTIR spectra, potentially opening up a new approach to degradation monitoring.

  17. Advanced coal-fueled gas turbine systems: Subscale combustion testing. Topical report, Task 3.1

    Energy Technology Data Exchange (ETDEWEB)

    1993-05-01

    This is the final report on the Subscale Combustor Testing performed at Textron Defense Systems` (TDS) Haverhill Combustion Laboratories for the Advanced Coal-Fueled Gas Turbine System Program of the Westinghouse Electric Corp. This program was initiated by the Department of Energy in 1986 as an R&D effort to establish the technology base for the commercial application of direct coal-fired gas turbines. The combustion system under consideration incorporates a modular staged, rich-lean-quench, Toroidal Vortex Slogging Combustor (TVC) concept. Fuel-rich conditions in the first stage inhibit NO{sub x} formation from fuel-bound nitrogen; molten coal ash and sulfated sorbent are removed, tapped and quenched from the combustion gases by inertial separation in the second stage. Final oxidation of the fuel-rich gases, and dilution to achieve the desired turbine inlet conditions are accomplished in the third stage, which is maintained sufficiently lean so that here, too, NO{sub x} formation is inhibited. The primary objective of this work was to verify the feasibility of a direct coal-fueled combustion system for combustion turbine applications. This has been accomplished by the design, fabrication, testing and operation of a subscale development-type coal-fired combustor. Because this was a complete departure from present-day turbine combustors and fuels, it was considered necessary to make a thorough evaluation of this design, and its operation in subscale, before applying it in commercial combustion turbine power systems.

  18. Hydroponics Database and Handbook for the Advanced Life Support Test Bed

    Science.gov (United States)

    Nash, Allen J.

    1999-01-01

    During the summer 1998, I did student assistance to Dr. Daniel J. Barta, chief plant growth expert at Johnson Space Center - NASA. We established the preliminary stages of a hydroponic crop growth database for the Advanced Life Support Systems Integration Test Bed, otherwise referred to as BIO-Plex (Biological Planetary Life Support Systems Test Complex). The database summarizes information from published technical papers by plant growth experts, and it includes bibliographical, environmental and harvest information based on plant growth under varying environmental conditions. I collected 84 lettuce entries, 14 soybean, 49 sweet potato, 16 wheat, 237 white potato, and 26 mix crop entries. The list will grow with the publication of new research. This database will be integrated with a search and systems analysis computer program that will cross-reference multiple parameters to determine optimum edible yield under varying parameters. Also, we have made preliminary effort to put together a crop handbook for BIO-Plex plant growth management. It will be a collection of information obtained from experts who provided recommendations on a particular crop's growing conditions. It includes bibliographic, environmental, nutrient solution, potential yield, harvest nutritional, and propagation procedure information. This handbook will stand as the baseline growth conditions for the first set of experiments in the BIO-Plex facility.

  19. Mechanism Development, Testing, and Lessons Learned for the Advanced Resistive Exercise Device

    Science.gov (United States)

    Lamoreaux, Christopher D.; Landeck, Mark E.

    2006-01-01

    The Advanced Resistive Exercise Device (ARED) has been developed at NASA Johnson Space Center, for the International Space Station (ISS) program. ARED is a multi-exercise, high-load resistive exercise device, designed for long duration, human space missions. ARED will enable astronauts to effectively maintain their muscle strength and bone mass in the micro-gravity environment more effectively than any other existing devices. ARED's resistance is provided via two, 20.3 cm (8 in) diameter vacuum cylinders, which provide a nearly constant resistance source. ARED also has a means to simulate the inertia that is felt during a 1-G exercise routine via the flywheel subassembly, which is directly tied to the motion of the ARED cylinders. ARED is scheduled to fly on flight ULF 2 to the ISS and will be located in Node 1. Presently, ARED is in the middle of its qualification and acceptance test program. An extensive testing program and engineering evaluation has increased the reliability of ARED by bringing potential design issues to light before flight production. Some of those design issues, resolutions, and design details will be discussed in this paper.

  20. Advanced coal-fueled gas turbine systems: Subscale combustion testing. Topical report, Task 3.1

    Energy Technology Data Exchange (ETDEWEB)

    1993-05-01

    This is the final report on the Subscale Combustor Testing performed at Textron Defense Systems` (TDS) Haverhill Combustion Laboratories for the Advanced Coal-Fueled Gas Turbine System Program of the Westinghouse Electric Corp. This program was initiated by the Department of Energy in 1986 as an R&D effort to establish the technology base for the commercial application of direct coal-fired gas turbines. The combustion system under consideration incorporates a modular staged, rich-lean-quench, Toroidal Vortex Slogging Combustor (TVC) concept. Fuel-rich conditions in the first stage inhibit NO{sub x} formation from fuel-bound nitrogen; molten coal ash and sulfated sorbent are removed, tapped and quenched from the combustion gases by inertial separation in the second stage. Final oxidation of the fuel-rich gases, and dilution to achieve the desired turbine inlet conditions are accomplished in the third stage, which is maintained sufficiently lean so that here, too, NO{sub x} formation is inhibited. The primary objective of this work was to verify the feasibility of a direct coal-fueled combustion system for combustion turbine applications. This has been accomplished by the design, fabrication, testing and operation of a subscale development-type coal-fired combustor. Because this was a complete departure from present-day turbine combustors and fuels, it was considered necessary to make a thorough evaluation of this design, and its operation in subscale, before applying it in commercial combustion turbine power systems.

  1. Multi-purpose utility of circulating plasma DNA testing in patients with advanced cancers.

    Science.gov (United States)

    Perkins, Geraldine; Yap, Timothy A; Pope, Lorna; Cassidy, Amy M; Dukes, Juliet P; Riisnaes, Ruth; Massard, Christophe; Cassier, Philippe A; Miranda, Susana; Clark, Jeremy; Denholm, Katie A; Thway, Khin; Gonzalez De Castro, David; Attard, Gerhardt; Molife, L Rhoda; Kaye, Stan B; Banerji, Udai; de Bono, Johann S

    2012-01-01

    Tumor genomic instability and selective treatment pressures result in clonal disease evolution; molecular stratification for molecularly targeted drug administration requires repeated access to tumor DNA. We hypothesized that circulating plasma DNA (cpDNA) in advanced cancer patients is largely derived from tumor, has prognostic utility, and can be utilized for multiplex tumor mutation sequencing when repeat biopsy is not feasible. We utilized the Sequenom MassArray System and OncoCarta panel for somatic mutation profiling. Matched samples, acquired from the same patient but at different time points were evaluated; these comprised formalin-fixed paraffin-embedded (FFPE) archival tumor tissue (primary and/or metastatic) and cpDNA. The feasibility, sensitivity, and specificity of this high-throughput, multiplex mutation detection approach was tested utilizing specimens acquired from 105 patients with solid tumors referred for participation in Phase I trials of molecularly targeted drugs. The median cpDNA concentration was 17 ng/ml (range: 0.5-1600); this was 3-fold higher than in healthy volunteers. Moreover, higher cpDNA concentrations associated with worse overall survival; there was an overall survival (OS) hazard ratio of 2.4 (95% CI 1.4, 4.2) for each 10-fold increase in cpDNA concentration and in multivariate analyses, cpDNA concentration, albumin, and performance status remained independent predictors of OS. These data suggest that plasma DNA in these cancer patients is largely derived from tumor. We also observed high detection concordance for critical 'hot-spot' mutations (KRAS, BRAF, PIK3CA) in matched cpDNA and archival tumor tissue, and important differences between archival tumor and cpDNA. This multiplex sequencing assay can be utilized to detect somatic mutations from plasma in advanced cancer patients, when safe repeat tumor biopsy is not feasible and genomic analysis of archival tumor is deemed insufficient. Overall, circulating nucleic acid

  2. Multi-purpose utility of circulating plasma DNA testing in patients with advanced cancers.

    Directory of Open Access Journals (Sweden)

    Geraldine Perkins

    Full Text Available Tumor genomic instability and selective treatment pressures result in clonal disease evolution; molecular stratification for molecularly targeted drug administration requires repeated access to tumor DNA. We hypothesized that circulating plasma DNA (cpDNA in advanced cancer patients is largely derived from tumor, has prognostic utility, and can be utilized for multiplex tumor mutation sequencing when repeat biopsy is not feasible. We utilized the Sequenom MassArray System and OncoCarta panel for somatic mutation profiling. Matched samples, acquired from the same patient but at different time points were evaluated; these comprised formalin-fixed paraffin-embedded (FFPE archival tumor tissue (primary and/or metastatic and cpDNA. The feasibility, sensitivity, and specificity of this high-throughput, multiplex mutation detection approach was tested utilizing specimens acquired from 105 patients with solid tumors referred for participation in Phase I trials of molecularly targeted drugs. The median cpDNA concentration was 17 ng/ml (range: 0.5-1600; this was 3-fold higher than in healthy volunteers. Moreover, higher cpDNA concentrations associated with worse overall survival; there was an overall survival (OS hazard ratio of 2.4 (95% CI 1.4, 4.2 for each 10-fold increase in cpDNA concentration and in multivariate analyses, cpDNA concentration, albumin, and performance status remained independent predictors of OS. These data suggest that plasma DNA in these cancer patients is largely derived from tumor. We also observed high detection concordance for critical 'hot-spot' mutations (KRAS, BRAF, PIK3CA in matched cpDNA and archival tumor tissue, and important differences between archival tumor and cpDNA. This multiplex sequencing assay can be utilized to detect somatic mutations from plasma in advanced cancer patients, when safe repeat tumor biopsy is not feasible and genomic analysis of archival tumor is deemed insufficient. Overall, circulating nucleic

  3. Correlations between physical properties, formulations, and ATR FTIR spectra of polyurethane foams

    Science.gov (United States)

    Caughran, Joel A.; Bhat, Sanmitra A.; de Haseth, James A.

    1994-01-01

    Polyurethane foams of varying surfactant, tin catalyst, and amine catalyst levels were prepared to find formulations that made `good' foams. A good foam is characterized by rise and density. Attenuated Total Reflectance spectra of the foams were collected after the foams were allowed to cure for 24 hours. Because the infrared spectrum shows morphology as well as structure, the ATR spectrum can be used to measure physical properties that are dependent on structure and morphology. The ATR FT-IR spectra were baseline corrected and then normalized by the area in the C-H stretch region to correct for differences in contact area with the ATR crystal. Samples were then taken from the cured foam parallel to the direction of rise to measure tensile strength and air permeability. Correlations were then made between the ATR spectra and the physical properties. Partial least squares (PLS) and principle component regression (PCR) were used to do the correlations.

  4. ATM, ATR and DNA-PKcs expressions correlate to adverse clinical outcomes in epithelial ovarian cancers

    Directory of Open Access Journals (Sweden)

    Tarek M.A. Abdel-Fatah

    2014-12-01

    General significance: The data presented here provides evidence that ATM, ATR and DNA-PKcs involved in DDR are not only promising biomarkers but are also rational targets for personalized therapy in ovarian cancer.

  5. Using NIR and ATR-FTIR spectroscopy to rapidly detect compression wood in Pinus radiata

    National Research Council Canada - National Science Library

    McLean, J. Paul; Jin, Guangwu; Brennan, Maree; Nieuwoudt, Michel K; Harris, Philip J

    2014-01-01

    .... Traditional methods of detecting it are often time consuming and subjective. This study aimed to rapidly and impartially detect compression wood through the use of attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR...

  6. Improving the Sandia Test Protocols with Advanced Inverter Functionality Testing of INV3, VV11, FW21, and L/HVRT

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, Jay Dean [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2013-11-01

    Sandia National Laboratories has created a test protocol for IEC TR 61850-90-7 advanced distributed energy resource (DER) functions, titled "Test Protocols for Advanced Inverter Interoperability Functions," often referred to as the Sandia Test Protocols. This document is currently in draft form, but has been shared with stakeholders around the world with the ultimate goal of collaborating to create a consensus set of test protocols which can be then incorporated into an International Electrotechnical Commission (IEC) and/or Underwriters Laboratories (UL) certification standard. The protocols are designed to ensure functional interoperability of DER (primarily photovoltaic (PV) inverters and energy storage systems) as specified by the IEC technical report through communication and electrical tests. In this report, Sandia exercises the electrical characterization portion of the test protocols for four functions: constant power factor (INV3), volt-var (VV11), frequency-watt (FW21), and Low and High Voltage Ride Through (L/HVRT). The goal of the tests reported here was not to characterize the performance of the equipment under test (EUT), but rather to (a) exercise the draft Sandia Test Protocols in order to identify any revisions needed in test procedures, conditions, or equipment and (b) gain experience with state-of-the-art DER equipment to determine if the tests put unrealistic or overly aggressive requirements on EUT operation. In performing the work according to the current versions of the protocols, Sandia was able to identify weaknesses in the current versions and suggest improvements to the test protocols.

  7. Feature separability analysis for SAR ATR using data description method

    Science.gov (United States)

    Guo, Weiwei; Du, Xiaoyong; Hu, WeiDong; Yu, Wenxian

    2007-11-01

    Feature extraction and selection play an important role in radar target recognition. This paper focuses on evaluating feature separability for SAR ATR and selecting the best subset of features. In details, fifteen features extracted from T72, BTR70 and BMP2 in MSTAR standard public dataset are examined, which are divided into seven categories: standard deviation, fractal dimension, weighted-rank fill ratio, size-related features, contrast-based features, count feature, projection feature, and moment features. Since the number of samples is small, a new separability criterion based on the overlap degree of each two class regions is proposed to assess the separability of these features. Here the class region is described by support vector data description (SVDD) method for good generalization. Based on the proposed criterion, a forward feature selection method is adopted to choose the best subset of features. Because of the strong variability of the feature against aspect, the features are analyzed under different aspect sectors within 360°angle range stepped by 15°, 30 °, and 60°, respectively. Experiments using MSTAR dataset validate the criterion, and the best subset of features is determined.

  8. Experimental active control of sound in the ATR 42

    Science.gov (United States)

    Paonessa, A.; Sollo, A.; Paxton, M.; Purver, M.; Ross, C. F.

    Passenger comfort is becoming day by day an important issue for the market of the regional turboprop aircraft and also for the future high speed propeller driven aircraft. In these aircraft the main contribution to the passenger annoyance is due to the propeller noise blade passing frequency (BPF) and its harmonics. In the recent past a detailed theoretical and experimental work has been done by Alenia Aeronautica in order to reduce the noise level in the ATR aircraft passenger cabin by means of conventional passive treatments: synchrophasing of propellers, dynamic vibration absorbers, structural reinforcements, damping materials. The application of these treatments has been introduced on production aircraft with a remarkable improvement of noise comfort but with a significant weight increase. For these reasons, a major technology step is required for reaching passenger comfort comparable to that of jet aircraft with the minimum weight increase. The most suitable approach to this problem has been envisaged in the active noise control which consists in generating an anti-sound field in the passenger cabin to reduce the noise at propeller BPF and its harmonics. The attenuation is reached by means of a control system which acquires information about the cabin noise distribution and the propeller speed during flight and simultaneously generates the signals to drive the speakers.

  9. Methods to probe protein transitions with ATR infrared spectroscopy.

    Science.gov (United States)

    Rich, Peter R; Iwaki, Masayo

    2007-06-01

    We describe techniques that can be used in conjunction with modern attenuated total reflection (ATR) infrared micro-prisms to allow proteins to be manipulated cyclically between different states whilst simultaneously monitoring both mid-IR and UV/visible/near IR changes. These methods provide increased flexibility of the types of changes that can be induced in proteins in comparison to transmission methods. Quantitative measurements can be made of vibrational changes associated with conversion between stable catalytic reaction intermediates, ligand binding and oxidation-reduction. Both hydrophobic and soluble proteins can be analysed and the ability to induce transitions repetitively allows IR difference spectra to be acquired at a signal/noise sufficient to resolve changes due to specific cofactors or amino acids. Such spectra can often be interpreted at the atomic level by standard IR methods of comparisons with model compounds, by isotope and mutation effects and, increasingly, by ab initio simulations. Combination of such analyses with atomic 3D structural models derived from X-ray and NMR studies can lead to a deeper understanding of molecular mechanisms of enzymatic reactions.

  10. Advanced Electron Microscopy and Micro analytical technique development and application for Irradiated TRISO Coated Particles from the AGR-1 Experiment

    Energy Technology Data Exchange (ETDEWEB)

    Van Rooyen, Isabella Johanna [Idaho National Lab. (INL), Idaho Falls, ID (United States); Lillo, Thomas Martin [Idaho National Lab. (INL), Idaho Falls, ID (United States); Wen, Haiming [Idaho National Lab. (INL), Idaho Falls, ID (United States); Wright, Karen Elizabeth [Idaho National Lab. (INL), Idaho Falls, ID (United States); Madden, James Wayne [Idaho National Lab. (INL), Idaho Falls, ID (United States); Aguiar, Jeffery Andrew [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2017-01-01

    A series of up to seven irradiation experiments are planned for the Advanced Gas Reactor (AGR) Fuel Development and Quantification Program, with irradiation completed at the Advanced Test Reactor (ATR) at Idaho National Laboratory (INL) for the first experiment (i.e., AGR-1) in November 2009 for an effective 620 full power days. The objective of the AGR-1 experiment was primarily to provide lessons learned on the multi-capsule test train design and to provide early data on fuel performance for use in fuel fabrication process development and post-irradiation safety testing data at high temperatures. This report describes the advanced microscopy and micro-analysis results on selected AGR-1 coated particles.

  11. Advanced topographic laser altimeter system (ATLAS) receiver telescope assembly (RTA) and transmitter alignment and test

    Science.gov (United States)

    Hagopian, John; Bolcar, Matthew; Chambers, John; Crane, Allen; Eegholm, Bente; Evans, Tyler; Hetherington, Samuel; Mentzell, Eric; Thompson, Patrick L.; Ramos-Izquierdo, Luis; Vaughnn, David

    2016-09-01

    The sole instrument on NASA's ICESat-2 spacecraft shown in Figure 1 will be the Advanced Topographic Laser Altimeter System (ATLAS)1. The ATLAS is a Light Detection and Ranging (LIDAR) instrument; it measures the time of flight of the six transmitted laser beams to the Earth and back to determine altitude for geospatial mapping of global ice. The ATLAS laser beam is split into 6 main beams by a Diffractive Optical Element (DOE) that are reflected off of the earth and imaged by an 800 mm diameter Receiver Telescope Assembly (RTA). The RTA is composed of a 2-mirror telescope and Aft Optics Assembly (AOA) that collects and focuses the light from the 6 probe beams into 6 science fibers. Each fiber optic has a field of view on the earth that subtends 83 micro Radians. The light collected by each fiber is detected by a photomultiplier and timing related to a master clock to determine time of flight and therefore distance. The collection of the light from the 6 laser spots projected to the ground allows for dense cross track sampling to provide for slope measurements of ice fields. NASA LIDAR instruments typically utilize telescopes that are not diffraction limited since they function as a light collector rather than imaging function. The more challenging requirements of the ATLAS instrument require better performance of the telescope at the ¼ wave level to provide for improved sampling and signal to noise. NASA Goddard Space Flight Center (GSFC) contracted the build of the telescope to General Dynamics (GD). GD fabricated and tested the flight and flight spare telescope and then integrated the government supplied AOA for testing of the RTA before and after vibration qualification. The RTA was then delivered to GSFC for independent verification and testing over expected thermal vacuum conditions. The testing at GSFC included a measurement of the RTA wavefront error and encircled energy in several orientations to determine the expected zero gravity figure, encircled

  12. Utility advanced turbine systems (ATS) technology readiness testing -- Phase 3. Annual report, October 1, 1996--September 30, 1997

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-12-31

    The overall objective of the Advanced Turbine System (ATS) Phase 3 Cooperative Agreement between GE and the US Department of Energy (DOE) is the development of the GE 7H and 9H combined cycle power systems. The major effort will be expended on detail design. Validation of critical components and technologies will be performed including: hot gas path component testing, sub-scale compressor testing, steam purity test trials, and rotational heat transfer confirmation testing. Processes will be developed to support the manufacture of the first system. Technology enhancements that are not required for the first machine design but will be critical for future ATS advances in performance, reliability, and costs will be initiated. Long-term tests of materials to confirm design life predictions will continue. A schematic of the GE H machine is shown.

  13. Utility advanced turbine systems (ATS) technology readiness testing and pre-commercial demonstration. Quarterly report, April 1--June 30, 1997

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-12-31

    The overall objective of the Advanced Turbine System (ATS) Phase 3 Cooperative Agreement between GE and the US Department of Energy (DOE) is the development of the GE 7H and 9H combined cycle power systems. The major effort will be expended on detail design. Validation of critical components and technologies will be performed including: hot gas path component testing, sub-scale compressor testing, steam purity test trials, and rotational heat transfer confirmation testing. Processes will be developed to support the manufacture of the first system, which will be sited and operated in Phase 4. Technology enhancements that are not required for the first machine design but will be critical for future ATS advances in performance, reliability, and costs will be initiated. Long-term tests of materials to confirm design life predictions will continue. A schematic of the GE H machine is shown. This report summarizes work accomplished in 2Q97.

  14. Utility Advanced Turbine Systems (ATS) technology readiness testing and pre-commercialization demonstration. Quarterly report, October 1--December 31, 1996

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-06-01

    The overall objective of the Advanced Turbine System (ATS) Phase 3 Cooperative Agreement between GE and the U.S. Department of Energy (DOE) is the development of the GE 7H and 9H combined cycle power systems. The major effort will be expended on detail design. Validation of critical components and technologies will be performed including: hot gas path component testing, sub-scale compressor testing, steam purity test trials, and rotational heat transfer confirmation testing. Processes will be developed to support the manufacture of the first system, which will be sited and operated in Phase 4. Technology enhancements that are not required for the first machine design but will be critical for future ATS advances in performance, reliability, and costs will be initiated. Long-term tests of materials to confirm design life predictions will continue.

  15. Utility advanced turbine systems (ATS) technology readiness testing and pre-commercial demonstration. Quarterly report, January 1--March 31, 1997

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-12-31

    The overall objective of the Advanced Turbine System (ATS) Phase 3 Cooperative Agreement between GE and the US Department of Energy (DOE) is the development of the GE 7H and 9H combined cycle power systems. The major effort will be expended on detail design. Validation of critical components and technologies will be performed including: hot gas path component testing, sub-scale compressor testing, steam purity test trials, and rotational heat transfer confirmation testing. Processes will be developed to support the manufacture of the first system, which will be sited and operated in Phase 4. Technology enhancements that are not required for the first machine design but will be critical for future ATS advances in performance, reliability, and costs will be initiated. Long-term tests of materials to confirm design life predictions will continue. A schematic of the GE H machine is shown. This report summarizes work accomplished in 1Q97.

  16. Test-retest reliability of UPDRS-III, dyskinesia scales, and timed motor tests in patients with advanced Parkinson's disease: an argument against multiple baseline assessments.

    Science.gov (United States)

    Metman, Leo Verhagen; Myre, Brian; Verwey, Niek; Hassin-Baer, Sharon; Arzbaecher, Jean; Sierens, Diane; Bakay, Roy

    2004-09-01

    The primary objective of this study was to assess the intra-rater reliability of the motor section of the Unified Parkinson's Disease Rating Scale (UPDRS-III) in patients with advanced Parkinson's disease (PD). The secondary objective was to assess the intra-rater reliability of standard timed motor tests and dyskinesia scales to determine the necessity of multiple baseline core evaluations before surgery for PD. We carried out two standardized preoperative core evaluations of patients with advanced PD scheduled to undergo deep brain stimulation. Patients were examined in the defined off and on conditions by the same rater. UPDRS-III, timed tests, and dyskinesia scores from the two evaluations were compared using Wilcoxon Signed Ranks tests and intraclass correlation coefficients (ICC). Differences in UPDRS-III scores for the two visits were clinically and statistically nonsignificant, and the ICC was 0.9. Similarly, there were no significant differences in timed motor tests or dyskinesia scores, with a median ICC of 0.8. The results indicate that previous findings of high test-retest reliability of UPDRS-III in early untreated PD patients can now be extended to those with advanced disease complicated by motor fluctuations. In addition, test-retest reliability of dyskinesia scales and timed motor tests was high. Taken together, these findings challenge the need for multiple baseline assessments as currently stipulated in core assessment protocols for surgical intervention in PD.

  17. An expanded framework for the advanced computational testing and simulation toolkit

    Energy Technology Data Exchange (ETDEWEB)

    Marques, Osni A.; Drummond, Leroy A.

    2003-11-09

    The Advanced Computational Testing and Simulation (ACTS) Toolkit is a set of computational tools developed primarily at DOE laboratories and is aimed at simplifying the solution of common and important computational problems. The use of the tools reduces the development time for new codes and the tools provide functionality that might not otherwise be available. This document outlines an agenda for expanding the scope of the ACTS Project based on lessons learned from current activities. Highlights of this agenda include peer-reviewed certification of new tools; finding tools to solve problems that are not currently addressed by the Toolkit; working in collaboration with other software initiatives and DOE computer facilities; expanding outreach efforts; promoting interoperability, further development of the tools; and improving functionality of the ACTS Information Center, among other tasks. The ultimate goal is to make the ACTS tools more widely used and more effective in solving DOE's and the nation's scientific problems through the creation of a reliable software infrastructure for scientific computing.

  18. Beyond BRAFV600: clinical mutation panel testing by next-generation sequencing in advanced melanoma

    Science.gov (United States)

    Siroy, Alan E.; Boland, Genevieve M.; Milton, Denái R.; Roszik, Jason; Frankian, Silva; Malke, Jared; Haydu, Lauren; Prieto, Victor G.; Tetzlaff, Michael; Ivan, Doina; Wang, Wei-Lien; Torres-Cabala, Carlos; Curry, Jonathan; Roy-Chowdhuri, Sinchita; Broaddus, Russell; Rashid, Asif; Stewart, John; Gershenwald, Jeffrey E.; Amaria, Rodabe N.; Patel, Sapna P.; Papadopoulos, Nicholas E.; Bedikian, Agop; Hwu, Wen-Jen; Hwu, Patrick; Diab, Adi; Woodman, Scott E.; Aldape, Kenneth D.; Luthra, Rajyalakshmi; Patel, Keyur P.; Shaw, Kenna R.; Mills, Gordon B.; Mendelsohn, John; Meric-Bernstam, Funda; Kim, Kevin B.; Routbort, Mark J.; Lazar, Alexander J.; Davies, Michael A.

    2014-01-01

    The management of melanoma has evolved due to improved understanding of its molecular drivers. To augment the current understanding of the prevalence, patterns, and associations of mutations in this disease, the results of clinical testing of 699 advanced melanoma patients using a pan-cancer next generation sequencing (NGS) panel of hotspot regions in 46 genes were reviewed. Mutations were identified in 43 of the 46 genes on the panel. The most common mutations were BRAFV600 (36%), NRAS (21%), TP53 (16%), BRAFNon-V600 (6%), and KIT (4%). Approximately one-third of melanomas had >1 mutation detected, and the number of mutations per tumor was associated with melanoma subtype. Concurrent TP53 mutations were the most frequent event in tumors with BRAFV600 and NRAS mutations. Melanomas with BRAFNon-V600 mutations frequently harbored concurrent NRAS mutations (18%), which were rare in tumors with BRAFV600 mutations (1.6%). The prevalence of BRAFV600 and KIT mutations were significantly associated with melanoma subtypes, and BRAFV600 and TP53 mutations were significantly associated with cutaneous primary tumor location. Multiple potential therapeutic targets were identified in metastatic unknown primary and cutaneous melanomas that lacked BRAFV600 and NRAS mutations. These results enrich our understanding of the patterns and clinical associations of oncogenic mutations in melanoma. PMID:25148578

  19. Identifying the mechanisms of drug release from amorphous solid dispersions using MRI and ATR-FTIR spectroscopic imaging.

    Science.gov (United States)

    Punčochová, Kateřina; Ewing, Andrew V; Gajdošová, Michaela; Sarvašová, Nina; Kazarian, Sergei G; Beránek, Josef; Štěpánek, František

    2015-04-10

    The dissolution mechanism of a poorly aqueous soluble drug from amorphous solid dispersions was investigated using a combination of two imaging methods: attenuated total reflection-Fourier transform infrared (ATR-FTIR) spectroscopic imaging and magnetic resonance imaging (MRI). The rates of elementary processes such as water penetration, polymer swelling, growth and erosion of gel layer, and the diffusion, release and in some cases precipitation of drug were evaluated by image analysis. The results from the imaging methods were compared with drug release profiles obtained by classical dissolution tests. The study was conducted using three polymeric excipients (soluplus, polyvinylpyrrolidone - PVP K30, hydroxypropylmethyl cellulose - HPMC 100M) alone and in combination with a poorly soluble drug, aprepitant. The imaging methods were complementary: ATR-FTIR imaging enabled a qualitative observation of all three components during the dissolution experiments, water, polymer and drug, including identifying structural changes from the amorphous form of drug to the crystalline form. The comparison of quantitative MRI data with drug release profiles enabled the different processes during dissolution to be established and the rate-limiting step to be identified, which - for the drug-polymer combinations investigated in this work - was the drug diffusion through the gel layer rather than water penetration into the tablet.

  20. Test Review: Advanced Clinical Solutions for WAIS-IV and WMS-IV

    Science.gov (United States)

    Chu, Yiting; Lai, Mark H. C.; Xu, Yining; Zhou, Yuanyuan

    2012-01-01

    The authors review the "Advanced Clinical Solutions for WAIS-IV and WMS-IV". The "Advanced Clinical Solutions (ACS) for the Wechsler Adult Intelligence Scale-Fourth Edition" (WAIS-IV; Wechsler, 2008) and the "Wechsler Memory Scale-Fourth Edition" (WMS-IV; Wechsler, 2009) was published by Pearson in 2009. It is a clinical tool for extending the…

  1. Test Review: Advanced Clinical Solutions for WAIS-IV and WMS-IV

    Science.gov (United States)

    Chu, Yiting; Lai, Mark H. C.; Xu, Yining; Zhou, Yuanyuan

    2012-01-01

    The authors review the "Advanced Clinical Solutions for WAIS-IV and WMS-IV". The "Advanced Clinical Solutions (ACS) for the Wechsler Adult Intelligence Scale-Fourth Edition" (WAIS-IV; Wechsler, 2008) and the "Wechsler Memory Scale-Fourth Edition" (WMS-IV; Wechsler, 2009) was published by Pearson in 2009. It is a…

  2. Test Review: Advanced Clinical Solutions for WAIS-IV and WMS-IV

    Science.gov (United States)

    Chu, Yiting; Lai, Mark H. C.; Xu, Yining; Zhou, Yuanyuan

    2012-01-01

    The authors review the "Advanced Clinical Solutions for WAIS-IV and WMS-IV". The "Advanced Clinical Solutions (ACS) for the Wechsler Adult Intelligence Scale-Fourth Edition" (WAIS-IV; Wechsler, 2008) and the "Wechsler Memory Scale-Fourth Edition" (WMS-IV; Wechsler, 2009) was published by Pearson in 2009. It is a…

  3. Testing of advanced technique for linear lattice and closed orbit correction by modeling its application for iota ring at Fermilab

    Energy Technology Data Exchange (ETDEWEB)

    Romanov, A. [Fermilab

    2016-10-09

    Many modern and most future accelerators rely on precise configuration of lattice and trajectory. The Integrable Optics Test Accelerator (IOTA) at Fermilab that is coming to final stages of construction will be used to test advanced approaches of control over particles dynamics. Various experiments planned at IOTA require high flexibility of lattice configuration as well as high precision of lattice and closed orbit control. Dense element placement does not allow to have ideal configuration of diagnostics and correctors for all planned experiments. To overcome this limitations advanced method of lattice an beneficial for other machines. Developed algorithm is based on LOCO approach, extended with various sets of other experimental data, such as dispersion, BPM BPM phase advances, beam shape information from synchrotron light monitors, responses of closed orbit bumps to variations of focusing elements and other. Extensive modeling of corrections for a big number of random seed errors is used to illustrate benefits from developed approach.

  4. ATRC Neutron Detector Testing Quick Look Report

    Energy Technology Data Exchange (ETDEWEB)

    Troy C. Unruh; Benjamin M. Chase; Joy L. Rempe

    2013-08-01

    As part of the Advanced Test Reactor (ATR) National Scientific User Facility (NSUF) program, a joint Idaho State University (ISU) / French Alternative Energies and Atomic Energy Commission (CEA) / Idaho National Laboratory (INL) project was initiated in FY-10 to investigate the feasibility of using neutron sensors to provide online measurements of the neutron flux and fission reaction rate in the ATR Critical Facility (ATRC). A second objective was to provide initial neutron spectrum and flux distribution information for physics modeling and code validation using neutron activation based techniques in ATRC as well as ATR during depressurized operations. Detailed activation spectrometry measurements were made in the flux traps and in selected fuel elements, along with standard fission rate distribution measurements at selected core locations. These measurements provide additional calibration data for the real-time sensors of interest as well as provide benchmark neutronics data that will be useful for the ATR Life Extension Program (LEP) Computational Methods and V&V Upgrade project. As part of this effort, techniques developed by Prof. George Imel will be applied by Idaho State University (ISU) for assessing the performance of various flux detectors to develop detailed procedures for initial and follow-on calibrations of these sensors. In addition to comparing data obtained from each type of detector, calculations will be performed to assess the performance of and reduce uncertainties in flux detection sensors and compare data obtained from these sensors with existing integral methods employed at the ATRC. The neutron detectors required for this project were provided to team participants at no cost. Activation detectors (foils and wires) from an existing, well-characterized INL inventory were employed. Furthermore, as part of an on-going ATR NSUF international cooperation, the CEA sent INL three miniature fission chambers (one for detecting fast flux and two for

  5. Advanced age, cardiovascular risk burden, and timed up and go test performance in Parkinson disease.

    Science.gov (United States)

    Kotagal, Vikas; Albin, Roger L; Müller, Martijn L T M; Koeppe, Robert A; Studenski, Stephanie; Frey, Kirk A; Bohnen, Nicolaas I

    2014-12-01

    Cardiovascular comorbidities are a known risk factor for impaired mobility in elderly individuals. Motor impairments in Parkinson disease are conventionally ascribed to nigrostriatal dopaminergic denervation although progressive gait and balance impairments become more common with aging and often show limited response to dopaminergic replacement therapies. We explored the association between elevated cardiovascular risk factors and performance on the Timed Up and Go test in cross-sectional of Parkinson disease subjects (n = 83). Cardiovascular risk factor status was estimated using the Framingham General Cardiovascular Disease risk-scoring algorithm in order to dichotomize the cohort into those with and without elevated modifiable cardiovascular risk compared with normative scores for age and gender. All subjects underwent clinical and neuroimaging evaluations including a 3-m Timed Up and Go test, [(11)C]dihydrotetrabenazine positron emission tomography imaging to estimate nigrostriatal dopamine terminal loss, and an magnetic resonance imaging assessment of leukoaraiosis. A similar analysis was performed in 49 healthy controls. After adjusting for disease duration, leukoaraiosis, and nigrostriatal dopaminergic denervation, Parkinson disease subjects with elevated Framingham risk scores (n = 61) displayed slower Timed Up and Go test performance (β = 1.86, t = 2.41, p = .018) compared with subjects with normal range Framingham risk scores (n = 22). When age ≥65 was added to the model in a post hoc analysis, the strength of effect seen with older age (β = 1.51, t = 2.44, p = .017) was similar to that of elevated Framingham risk scoring (β = 1.87, t = 2.51, p = .014). In a multivariable regression model studying the healthy control population, advanced age (t = 2.15, p = .037) was a significant predictor of Timed Up and Go speed though striatal [(11)C]dihydrotetrabenazine (t = -1.30, p = .19) and elevated Framingham risk scores (t = 1.32, p = .19) were not

  6. Development and Testing of a Decision Aid on Goals of Care for Advanced Dementia

    Science.gov (United States)

    Einterz, Seth F.; Gilliam, Robin; Lin, Feng Chang; McBride, J. Marvin; Hanson, Laura C.

    2014-01-01

    Objectives Decision aids are effective to improve decision-making, yet they are rarely tested in nursing homes (NHs). Study objectives were to 1) examine the feasibility of a Goals of Care (GOC) decision aid for surrogate decision-makers (SDMs)of persons with dementia; and 2) test its effect on quality of communication and decision-making. Design Pre-post intervention to test a GOC decision aid intervention for SDMs for persons with dementia in NHs. Investigators collected data from reviews of resident health records and interviews with SDMs at baseline and 3-month follow up. Setting Two NHs in North Carolina. Participants 18 residents who were over 65 years of age, had moderate to severe dementia on the Global Deterioration Scale (GDS=5,6,7), and an English-speaking surrogate decision-maker. Intervention 1) GOC Decision Aid video viewed by the SDM, and 2) a structured care plan meeting between the SDM and interdisciplinary NH team Measurements Surrogate knowledge, quality of communication with health care providers, surrogate-provider concordance on goals of care, and palliative care domains addressed in the care plan. Results 89% of the SDMs thought the decision aid was relevant to their needs. After viewing the video decision aid, SDMs increased the number of correct responses on knowledge-based questions (12.5 vs 14.2, P<.001). At 3 months they reported improved quality of communication scores (6.1 vs 6.8, P=.01) and improved concordance on primary goal of care with nursing home team (50% vs 78%, P=.003). The number of palliative care domains addressed in the care plan increased (1.8 vs 4.3, P<.001). Conclusion The decision-support intervention piloted in this study was feasible and relevant for surrogate decision-makers of persons with advanced dementia in nursing homes, and it improved quality of communication between SDM and NH providers. A larger randomized clinical trial is underway to provide further evidence of the effects of this decision aid

  7. Advanced Photovoltaic Inverter Functionality using 500 kW Power Hardware-in-Loop Complete System Laboratory Testing: Preprint

    Energy Technology Data Exchange (ETDEWEB)

    Mather, B. A.; Kromer, M. A.; Casey, L.

    2013-01-01

    With the increasing penetration of distribution connected photovoltaic (PV) systems, more and more PV developers and utilities are interested in easing future PV interconnection concerns by mitigating some of the impacts of PV integration using advanced PV inverter controls and functions. This paper describes the testing of a 500 kW PV inverter using Power Hardware-in-Loop (PHIL) testing techniques. The test setup is described and the results from testing the inverter in advanced functionality modes, not commonly used in currently interconnected PV systems, are presented. PV inverter operation under PHIL evaluation that emulated both the DC PV array connection and the AC distribution level grid connection are shown for constant power factor (PF) and constant reactive power (VAr) control modes. The evaluation of these modes was completed under varying degrees of modeled PV variability.

  8. Validation of the Physics Analysis used to Characterize the AGR-1 TRISO Fuel Irradiation Test

    Energy Technology Data Exchange (ETDEWEB)

    Sterbentz, James W.; Harp, Jason M.; Demkowicz, Paul A.; Hawkes, Grant L.; Chang, Gray S.

    2015-05-01

    The results of a detailed physics depletion calculation used to characterize the AGR-1 TRISO-coated particle fuel test irradiated in the Advanced Test Reactor (ATR) at the Idaho National Laboratory are compared to measured data for the purpose of validation. The particle fuel was irradiated for 13 ATR power cycles over three calendar years. The physics analysis predicts compact burnups ranging from 11.30-19.56% FIMA and cumulative neutron fast fluence from 2.21?4.39E+25 n/m2 under simulated high-temperature gas-cooled reactor conditions in the ATR. The physics depletion calculation can provide a full characterization of all 72 irradiated TRISO-coated particle compacts during and post-irradiation, so validation of this physics calculation was a top priority. The validation of the physics analysis was done through comparisons with available measured experimental data which included: 1) high-resolution gamma scans for compact activity and burnup, 2) mass spectrometry for compact burnup, 3) flux wires for cumulative fast fluence, and 4) mass spectrometry for individual actinide and fission product concentrations. The measured data are generally in very good agreement with the calculated results, and therefore provide an adequate validation of the physics analysis and the results used to characterize the irradiated AGR-1 TRISO fuel.

  9. Challenges in analysing data from a field operational test of advanced driver assistance systems: the euroFOT experience

    NARCIS (Netherlands)

    Benmimoun, A.; Benmimoun, M.; Regan, M.A.; Noort, M. van; Wilmink, I.R.

    2010-01-01

    This paper discusses the challenges in analysing the data from the large scale field operational test (FOT) to be conducted within the EC euroFOT project. The euroFOT project aims to investigate the impacts of advanced driver assistance systems (ADAS) and to encourage their deployment. Started withi

  10. Testing the Development of French Word Knowledge by Advanced Dutch- and English-Speaking Learners and Native Speakers

    Science.gov (United States)

    Greidanus, Tine; Beks, Bianca; Wakely, Richard

    2005-01-01

    The present study is a continuation of the work presented in the 2001 article by Greidanus and Nienhuis. In the current study, we also examine the quality of word knowledge among advanced learners of French as a second language (L2) by means of a word associates test. We studied the development of word knowledge among 6 groups of university-level…

  11. Structural Benchmark Creep Testing for Microcast MarM-247 Advanced Stirling Convertor E2 Heater Head Test Article SN18

    Science.gov (United States)

    Krause, David L.; Brewer, Ethan J.; Pawlik, Ralph

    2013-01-01

    This report provides test methodology details and qualitative results for the first structural benchmark creep test of an Advanced Stirling Convertor (ASC) heater head of ASC-E2 design heritage. The test article was recovered from a flight-like Microcast MarM-247 heater head specimen previously used in helium permeability testing. The test article was utilized for benchmark creep test rig preparation, wall thickness and diametral laser scan hardware metrological developments, and induction heater custom coil experiments. In addition, a benchmark creep test was performed, terminated after one week when through-thickness cracks propagated at thermocouple weld locations. Following this, it was used to develop a unique temperature measurement methodology using contact thermocouples, thereby enabling future benchmark testing to be performed without the use of conventional welded thermocouples, proven problematic for the alloy. This report includes an overview of heater head structural benchmark creep testing, the origin of this particular test article, test configuration developments accomplished using the test article, creep predictions for its benchmark creep test, qualitative structural benchmark creep test results, and a short summary.

  12. Thermal and electrical joint test for the helical field coils in the Advanced Toroidal Facility

    Energy Technology Data Exchange (ETDEWEB)

    Brown, R.L.; Johnson, R.L.

    1985-01-01

    Initial feasibility studies of a number of configurations for the Advanced Toroidal Facility (ATF) resulted in the selection of a resistive copper continuous-coil torsatron as the optimum device considering the physics program, cost, and schedule. Further conceptual design work was directed toward optimization of this configuration and, if possible, a shorter schedule. It soon became obvious that in order to shorten the schedule, a number of design and fabrication activities should proceed in parallel. This was most critical for the vacuum vessel and the helical field (HF) coils. If the HF coils were wound in place on a completed vacuum vessel, the overall schedule would be significantly (greater than or equal to12 months) longer. The approach of parallel scheduel paths requires that the HF coils be segmented into parts of less than or equal to180 of poloidal angle and that joints be made on a turn-by-turn basis when the segments are installed. It was obvious from the outset that the compact and complex geometry of the joint design presented a special challenge in the areas of reliability, assembly, maintenance, disassembly, and cost. Also, electrical, thermal, and force excursions are significant for these joints. A number of soldered, welded, brazed, electroplated, and bolted joints were evaluated. The evaluations examined fabrication feasibility and complexity, thermal-electrical performance at approximately two-thirds of the steady-state design conditions, and installation and assembly processes. Results of the thermal-electrical tests were analyzed and extrapolated to predict performance at peak design parameters. The final selection was a lap-type joint clamped with insulated bolts that pass through the winding packing. 3 refs., 4 figs.

  13. Advanced neutron source reactor thermal-hydraulic test loop facility description

    Energy Technology Data Exchange (ETDEWEB)

    Felde, D.K.; Farquharson, G.; Hardy, J.H.; King, J.F.; McFee, M.T.; Montgomery, B.H.; Pawel, R.E.; Power, B.H.; Shourbaji, A.A.; Siman-Tov, M.; Wood, R.J.; Yoder, G.L.

    1994-02-01

    The Thermal-Hydraulic Test Loop (THTL) is a facility for experiments constructed to support the development of the Advanced Neutron Source Reactor (ANSR) at Oak Ridge National Laboratory. The ANSR is both cooled and moderated by heavy water and uses uranium silicide fuel. The core is composed of two coaxial fuel-element annuli, each of different diameter. There are 684 parallel aluminum-clad fuel plates (252 in the inner-lower core and 432 in the outer-upper core) arranged in an involute geometry that effectively creates an array of thin rectangular flow channels. Both the fuel plates and the coolant channels are 1.27 mm thick, with a span of 87 mm (lower core), 70 mm (upper core), and 507-mm heated length. The coolant flows vertically upwards at a mass flux of 27 Mg/m{sup 2}s (inlet velocity of 25 m/s) with an inlet temperature of 45{degrees}C and inlet pressure of 3.2 MPa. The average and peak heat fluxes are approximately 6 and 12 MW/m{sup 2}, respectively. The availability of experimental data for both flow excursion (FE) and true critical heat flux (CHF) at the conditions applicable to the ANSR is very limited. The THTL was designed and built to simulate a full-length coolant subchannel of the core, allowing experimental determination of thermal limits under the expected ANSR thermal-hydraulic conditions. For these experimental studies, the involute-shaped fuel plates of the ANSR core with the narrow 1.27-mm flow gap are represented by a narrow rectangular channel. Tests in the THTL will provide both single- and two-phase thermal-hydraulic information. The specific phenomena that are to be examined are (1) single-phase heat-transfer coefficients and friction factors, (2) the point of incipient boiling, (3) nucleate boiling heat-transfer coefficients, (4) two-phase pressure-drop characteristics in the nucleate boiling regime, (5) flow instability limits, and (6) CHF limits.

  14. Detection Limits for Blood on Fabrics Using Attenuated Total Reflection Fourier Transform Infrared (ATR FT-IR) Spectroscopy and Derivative Processing.

    Science.gov (United States)

    Lu, Zhenyu; DeJong, Stephanie A; Cassidy, Brianna M; Belliveau, Raymond G; Myrick, Michael L; Morgan, Stephen L

    2016-06-27

    Attenuated total reflection Fourier transform infrared spectroscopy (ATR FT-IR) was used to detect blood stains based on signature protein absorption in the mid-IR region, where intensity changes in the spectrum can be related to blood concentration. Partial least squares regression (PLSR) was applied for multivariate calibrations of IR spectra of blood dilutions on four types of fabric (acrylic, nylon, polyester, and cotton). Gap derivatives (GDs) were applied as a preprocessing technique to optimize the performance of calibration models. We report a much improved IR detection limit (DL) for blood on cotton (2700× in dilution factor units) and the first IR DL reported for blood on nylon (250×). Due to sample heterogeneity caused by fabric hydrophobicity, acrylic fabric produced variable ATR FT-IR spectra that caused poor DLs in concentration units compared to previous work. Polyester showed a similar problem at low blood concentrations that lead to a relatively poor DL as well. However, the increased surface sensitivity and decreased penetration depth of ATR FT-IR make it an excellent choice for detection of small quantities of blood on the front surface of all fabrics tested (0.0010 µg for cotton, 0.0077 µg for nylon, 0.011 µg for acrylic, and 0.0066 µg for polyester).

  15. Evaluation of common tests for fracture characterisation of advanced high-strength sheet steels with the help of the FEA

    Science.gov (United States)

    Peshekhodov, I.; Dykiert, M.; Vucetic, M.; Behrens, B.-A.

    2016-11-01

    The paper presents results of evaluation of common tests for fracture characterization of advanced high-strength sheet steels with the help of the FEA. The tests include three in-plane shear tests, two uniaxial tension tests, two plane strain tension tests and two equibiaxial tension tests. Three high-strength steels with different yield loci, strain hardening rates and strengths in three different thicknesses each were used. The evaluation was performed based on the spatial distribution of the equivalent plastic strain and damage variable in the specimen at the moment of crack initiation as well as on the time variation of the stress state at the crack initiation location. For in-plane shear, uniaxial tension and plane strain tension, no test can be unconditionally recommended as disadvantages of all studied tests in these groups cannot be neglected. However, in each of these groups, a test can be chosen, which represents an acceptable compromise between its advantages and disadvantages: the shear test on an IFUM butterfly specimen for in-plane shear, the tensile test on a holed specimen for uniaxial tension and the tensile test on a waisted specimen for plane strain tension. On the contrary, the bulge test on a circular specimen with a punch of Ø 100 mm can be unconditionally recommended for equibiaxial tension. In the future, optimisation of the studied tests for in-plane shear, uniaxial tension and plane strain tension appears to be necessary.

  16. In-situ ATR-FTIR for characterization of thin biorelated polymer films

    Energy Technology Data Exchange (ETDEWEB)

    Müller, M., E-mail: mamuller@ipfdd.de [Leibniz Institute of Polymer Research Dresden (IPF Dresden), Hohe Straße 6, 01069 Dresden (Germany); Technical University of Dresden (TUD), Department of Chemistry and Food Chemistry, 01062 Dresden (Germany); Torger, B. [Leibniz Institute of Polymer Research Dresden (IPF Dresden), Hohe Straße 6, 01069 Dresden (Germany); Technical University of Dresden (TUD), Department of Chemistry and Food Chemistry, 01062 Dresden (Germany); Bittrich, E. [Leibniz Institute of Polymer Research Dresden (IPF Dresden), Hohe Straße 6, 01069 Dresden (Germany); Kaul, E.; Ionov, L. [Leibniz Institute of Polymer Research Dresden (IPF Dresden), Hohe Straße 6, 01069 Dresden (Germany); Technical University of Dresden (TUD), Department of Chemistry and Food Chemistry, 01062 Dresden (Germany); Uhlmann, P. [Leibniz Institute of Polymer Research Dresden (IPF Dresden), Hohe Straße 6, 01069 Dresden (Germany); Stamm, M. [Leibniz Institute of Polymer Research Dresden (IPF Dresden), Hohe Straße 6, 01069 Dresden (Germany); Technical University of Dresden (TUD), Department of Chemistry and Food Chemistry, 01062 Dresden (Germany)

    2014-04-01

    We present and review in-situ-attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopic data from thin biorelated polymer films useful for the modification and functionalization of polymer and inorganic materials and discuss their applications related to life sciences. A special ATR mirror attachment operated by the single-beam-sample-reference (SBSR) concept and housing a homebuilt thermostatable flow cell was used, which allows for appropriate background compensation and signal to noise ratio. ATR-FTIR data on the reactive deposition of dopamine on inorganic model surfaces are shown. Information on the structure and deposition pathway for such bioinspired melanin-like films is provided. ATR-FTIR data on thermosensitive polymer brushes of poly(N-isopropylacrylamide) (PNIPAAM) is then presented. The thermotropic hydration and hydrogen bonding behavior of PNIPAAM brush films is described. Finally, ATR-FTIR data on biorelated polyelectrolyte multilayers (PEM) are given together with details on PEM growth and detection. Applications of these latter films for biopassivation/activation and local drug delivery are addressed.

  17. Involvement of ATM/ATR-p38 MAPK cascade in MNNG induced G1-S arrest

    Institute of Scientific and Technical Information of China (English)

    Ke-Qing Zhu; Suo-Jiang Zhang

    2003-01-01

    AIM: To understand the effect of low concentration of Nmethyl-N′-nitro-nitrosoguanidine (MNNG), which is a widely distributed environmental mutagen and carcinogen especially for human gastric cancer, on DNA damage and to study its possible pathway in regulating cell cycle arrest.METHODS: The DNA damage effect was measured by Comet assay. A specific phospho-(Ser/Thr) ATM/ATR substrate antibody was used to detect the damage sensor by Western blot. p38 kinase activity was measured by direct kinase assay,and immunoprecipitation for the possible connection between ATM/ATR and p38 MAPK. Flow cytometry analysis and p38MAPK specific inhibitor SB203580 were combined to detect the possible cell cycle arrest by p38 MAPK.RESULTS: With the same low concentration MNNG exposure (0.2μM 2.5 h), Comet assays indicated that strand breaks accumulated, Western blot and kinase assay showed ATM/ATR and p38 kinase activated, immunoprecipitation showed phospho-ATM/ATR substrate antibody combined with both p38 MAPK antibody and phospho-p38 MAPK antibody, p38MAPK pathway was involved in the G1-S arrest.CONCLUSION: Activation of ATM/ATR by MNNG induced DNA damage leads to activation of p38 MAPK, which involves in the G1 checkpoint in mammalian cells.

  18. DESIGN, FABRICATION, AND TESTING OF AN ADVANCED, NON-POLLUTING TURBINE DRIVE GAS GENERATOR

    Energy Technology Data Exchange (ETDEWEB)

    Unknown

    2001-10-30

    The objectives of this report period were to continue the development of the Gas Generator design, to complete the hardware and ancillary hardware fabrication, and commence the Test Preparations for the testing of the non-polluting unique power turbine drive gas generator. Focus during this report period has been on testing the Gas Generator. Because of unacceptable delays encountered in a previously competitively selected test site, CES initiated a re-competition of our testing program and selected an alternate test site. Following that selection, CES used all available resources to make preparations for testing the 10 Mw Gas Generator at the new testing site facilities of NTS at Saugus, CA. A substantial portion of this report period was devoted to Testing Preparations, i.e. test facility development, cold- flow testing, calibration testing, performing igniter ignition testing, and then commencement of the completely assembled Gas Generator Assembly Testing, in process at this writing.

  19. Testing new tribo-systems for sheet metal forming of advanced high strength steels and stainless steels

    DEFF Research Database (Denmark)

    Bay, Niels; Ceron, Ermanno

    2014-01-01

    Testing of new tribo-systems in sheet metal forming has become an important issue due to new legislation, which forces industry to replace current, hazardous lubricants. The present paper summarizes the work done in a recent PhD project at the Technical University of Denmark on the development...... of a methodology for off-line testing of new tribo-systems for advanced high strength steels and stainless steels. The methodology is presented and applied to an industrial case, where different tribo-systems are tested. A universal sheet tribotester has been developed, which can run automatically repetitive...

  20. Advanced Prototype Fan Operating Experience, Post Test Evaluation, and Refurbishment for PLSS 2.0 Test Use

    Science.gov (United States)

    Hodgson, Edward; Oehler, William; Dionne, Steve; Converse, David; Jennings, Mallory A.

    2012-01-01

    NASA s plans for Extravehicular Activity (EVA) portable life support systems for future exploration missions result in different design requirements than those which led to the combined fan / pump / separator in the current ISS Extravehicular Mobility Unit (EMU). To meet these new requirements, NASA contracted with Hamilton Sundstrand to provide two new prototype fans designed to meet anticipated future system requirements. Based on design trade studies, a high speed fan with mechanical bearing support of the rotating elements and a novel non-metallic barrier canned motor design was developed and implemented in the deliverable prototypes. The prototypes, which used two different bearing lubricants, have been extensively tested in both stand-alone and integrated system tests in NASA laboratories and proven to meet the anticipated performance requirements. Subsequently, they have been subjected to post test inspection and analysis in Hamilton Sundstrand laboratories to assess the effects of integrated operation and resultant exposure to vent loop contaminants. Results have confirmed expectations that one of the lubricants would be superior in this application and the prototype fans have been reassembled with new bearings with the superior lubricant. They have now been returned to the Johnson Space Center for further testing and maturation as part of NASA s PLSS 2.0 integrated test effort. This paper will discuss the test history of these units, resulting test data, the results of post test evaluation, and plans for further testing in the near future.

  1. Affinity and enzyme-based biosensors: recent advances and emerging applications in cell analysis and point-of-care testing.

    Science.gov (United States)

    Liu, Ying; Matharu, Zimple; Howland, Michael C; Revzin, Alexander; Simonian, Aleksandr L

    2012-09-01

    The applications of biosensors range from environmental testing and biowarfare agent detection to clinical testing and cell analysis. In recent years, biosensors have become increasingly prevalent in clinical testing and point-of-care testing. This is driven in part by the desire to decrease the cost of health care, to shift some of the analytical tests from centralized facilities to "frontline" physicians and nurses, and to obtain more precise information more quickly about the health status of a patient. This article gives an overview of recent advances in the field of biosensors, focusing on biosensors based on enzymes, aptamers, antibodies, and phages. In addition, this article attempts to describe efforts to apply these biosensors to clinical testing and cell analysis.

  2. Computation of ATR Darmon points on non-geometrically modular elliptic curves

    CERN Document Server

    Guitart, Xavier

    2012-01-01

    ATR points were introduced by Darmon as a conjectural construction of algebraic points on certain elliptic curves for which in general the Heegner point method is not available. So far the only numerical evidence, provided by Darmon--Logan and G\\"artner, concerned curves arising as quotients of Shimura curves. In those special cases the ATR points can be obtained from the already existing Heegner points, thanks to results of Zhang and Darmon--Rotger--Zhao. In this paper we compute for the first time an algebraic ATR point on a curve which is not uniformizable by any Shimura curve, thus providing the first piece of numerical evidence that Darmon's construction works beyond geometric modularity. To this purpose we improve the method proposed by Darmon and Logan by removing the requirement that the real quadratic field be norm-euclidean, and accelerating the numerical integration of Hilbert modular forms.

  3. [Relationship between PMI and ATR-FTIR Spectral Changes in Swine Costal Cartilages and Ribs].

    Science.gov (United States)

    Yao, Yao; Wang, Qi; Jing, Xiao-li; Li, Bing; Zhang, Yin-ming; Wang, Zhi-jun; Li, Cheng-zhi; Lin, Han-cheng; Zhang, Ji; Huang, Ping; Wang, Zhen-yuan

    2016-02-01

    To analyze postmortem chemical changes in Landrace costal cartilages and ribs using attenuated total reflection-Fourier transform infrared (ATR-FTIR) spectroscopy, and to provide a novel technique for estimation of postmortem interval (PMI). The swines were sacrificed by hemorrhage and their costal cartilages and ribs were kept in 20 degrees C. The chemical analysis of the costal cartilages and ribs were performed using ATR-FTIR every 72 h. The correlation between the certain spectral parameters and PMI was also analyzed. The time-dependent changes of costal cartilages were more significant than ribs. There were no obvious changes for the main absorbance bands position, and some absorbance band ratios showed time-dependent changes and significant correlations with the PMI. ATR-FTIR has the ability to analyze postmortem chemical changes of the swine costal cartilages and ribs, and it can be a new method to estimate PMI based on spectroscopy.

  4. An attenuated total reflectance mid infrared (ATR-MIR) spectroscopy study of gelatinization in barley.

    Science.gov (United States)

    Cozzolino, D; Roumeliotis, S; Eglinton, J

    2014-08-08

    The aim of this study was to evaluate the use of attenuated total reflectance and mid infrared (ATR-MIR) spectroscopy and to understand the gelatinization and retro-gradation of flour barley samples and the relationship with malting quality. Samples were sourced from two commercial barley varieties exhibiting high hot water extract (HWE) namely Navigator (n=8), and Admiral (n=8). Samples were analysed using the Rapid Visco Analyser (RVA) and ATR-MIR analysis. These results showed that ATR-MIR spectroscopy is capable of characterising gel samples derived from barley flour samples having different malting characteristics. Infrared spectra can effectively represent a 'fingerprint' of the sample being analysed and can be used to simplify and reduce analytical times in the routine methods currently used. Copyright © 2014 Elsevier Ltd. All rights reserved.

  5. Measured Thermal and Fast Neutron Fluence Rates for ATF-1 Holders During ATR Cycle 157D

    Energy Technology Data Exchange (ETDEWEB)

    Smith, Larry Don [Idaho National Lab. (INL), Idaho Falls, ID (United States); Miller, David Torbet [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2016-03-01

    This report contains the thermal (2200 m/s) and fast (E>1MeV) neutron fluence rate data for the ATF-1 holders located in core for ATR Cycle 157D which were measured by the Radiation Measurements Laboratory (RML) as requested by the Power Reactor Programs (ATR Experiments) Radiation Measurements Work Order. This report contains measurements of the fluence rates corresponding to the particular elevations relative to the 80-ft. core elevation. The data in this report consist of (1) a table of the ATR power history and distribution, (2) a hard copy listing of all thermal and fast neutron fluence rates, and (3) plots of both the thermal and fast neutron fluence rates. The fluence rates reported are for the average power levels given in the table of power history and distribution.

  6. In-Pile Experiment of a New Hafnium Aluminide Composite Material to Enable Fast Neutron Testing in the Advanced Test Reactor

    Energy Technology Data Exchange (ETDEWEB)

    Donna Post Guillen; Douglas L. Porter; James R. Parry; Heng Ban

    2010-06-01

    A new hafnium aluminide composite material is being developed as a key component in a Boosted Fast Flux Loop (BFFL) system designed to provide fast neutron flux test capability in the Advanced Test Reactor. An absorber block comprised of hafnium aluminide (Al3Hf) particles (~23% by volume) dispersed in an aluminum matrix can absorb thermal neutrons and transfer heat from the experiment to pressurized water cooling channels. However, the thermophysical properties, such as thermal conductivity, of this material and the effect of irradiation are not known. This paper describes the design of an in-pile experiment to obtain such data to enable design and optimization of the BFFL neutron filter.

  7. Good test--retest reliability for standard and advanced false-belief tasks across a wide range of abilities.

    Science.gov (United States)

    Hughes, C; Adlam, A; Happé, F; Jackson, J; Taylor, A; Caspi, A

    2000-05-01

    Although tests of young children's understanding of mind have had a remarkable impact upon developmental and clinical psychological research over the past 20 years, very little is known about their reliability. Indeed, the only existing study of test-retest reliability suggests unacceptably poor results for first-order false-belief tasks (Mayes, Klin, Tercyak, Cicchetti, & Cohen, 1996), although this may in part reflect the nonstandard (video-based) procedures adopted by these authors. The present study had four major aims. The first was to re-examine the reliability of false-belief tasks, using more standard (puppet and storybook) procedures. The second was to assess whether the test-retest reliability of false-belief task performance is equivalent for children of contrasting ability levels. The third aim was to explore whether adopting an aggregate approach improves the reliability with which children's early mental-state awareness can be measured. The fourth aim was to examine for the first time the test-retest reliability of children's performances on more advanced theory-of-mind tasks. Our results suggest that most standard and advanced false-belief tasks do in fact show good test-retest reliability and internal consistency, with very strong test-retest correlations between aggregate scores for children of all levels of ability.

  8. Utility advanced turbine systems (ATS) technology readiness testing -- Phase 3. Technical progress report, October 1--December 31, 1997

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-12-31

    The overall objective of the Advanced Turbine System (ATS) Phase 3 Cooperative Agreement between GE and US Department of Energy (DOE) is the development of the GE 7H and 9H combined cycle power systems. The major effort will be expended on detail design. Validation of critical components and technologies will be performed including: hot gas path component testing, sub-scale compressor testing, steam purity test trials, and rotational heat transfer confirmation testing. Processes will be developed to support the manufacture of the first system, which was to have been sited and operated in Phase 4 but will now be sited and operated commercially by GE. This change has resulted from DOE`s request to GE for deletion of Phase 4 in favor of a restructured Phase 3 (as Phase 3R) to include full speed, no load (FSNL) testing of the 7H gas turbine. Technology enhancements that are not required for the first machine design but will be critical for future ATS advances in performance, reliability, and costs will be initiated. Long-term tests of materials to confirm design life predictions will continue. A schematic of the GE H machine is shown. This report summarizes work accomplished in 4Q97.

  9. Core Principles and Test Item Development for Advanced High School and Introductory University Level Food Science

    Science.gov (United States)

    Laing-Kean, Claudine A. M.

    2010-01-01

    Programs supported by the Carl D. Perkins Act of 2006 are required to operate under the state or national content standards, and are expected to carry out evaluation procedures that address accountability. The Indiana high school course, "Advanced Life Science: Foods" ("ALS: Foods") operates under the auspices of the Perkins Act. However, no broad…

  10. Core Principles and Test Item Development for Advanced High School and Introductory University Level Food Science

    Science.gov (United States)

    Laing-Kean, Claudine A. M.

    2010-01-01

    Programs supported by the Carl D. Perkins Act of 2006 are required to operate under the state or national content standards, and are expected to carry out evaluation procedures that address accountability. The Indiana high school course, "Advanced Life Science: Foods" ("ALS: Foods") operates under the auspices of the Perkins…

  11. 10 CFR 830 Major Modification Determination for the ATR Diesel Bus (E-3) and Switchgear Replacement

    Energy Technology Data Exchange (ETDEWEB)

    Noel Duckwtiz

    2011-05-01

    Near term replacement of aging and obsolescent original ATR equipment has become important to ensure ATR capability in support of NE’s long term national missions. To that end, a mission needs statement has been prepared for a non-major system acquisition which is comprised of three interdependent subprojects. The first project, subject of this determination, will replace the existent diesel-electrical bus (E-3) and associated switchgear. More specifically, INL proposes transitioning ATR to 100% commercial power with appropriate emergency backup to include: • Provide commercial power as the normal source of power to the ATR loads currently supplied by diesel-electric power. • Provide backup power to the critical ATR loads in the event of a loss of commercial power. • Replace obsolescent critical ATR power distribution equipment, e.g., switchgear, transformers, motor control centers, distribution panels. Completion of this and two other age-related projects (primary coolant pump and motor replacement and emergency firewater injection system replacement) will resolve major age related operational issues plus make a significant contribution in sustaining the ATR safety and reliability profile. The major modification criteria evaluation of the project pre-conceptual design identified several issues make the project a major modification: 1. Evaluation Criteria #2 (Footprint change). The addition of a new PC-4 structure to the ATR Facility to house safety-related SSCs requires careful attention to maintaining adherence to applicable engineering and nuclear safety design criteria (e.g., structural qualification, fire suppression) to ensure no adverse impacts to the safety-related functions of the housed equipment. 2. Evaluation Criteria #3 (Change of existing process). The change to the strategy for providing continuous reliable power to the safety-related emergency coolant pumps requires careful attention and analysis to ensure it meets a project primary object

  12. Beliefs,Anxiety,Motivation in English Language Learning and Its Pedagogical Implication for Module Advancement Teaching and Testing

    Institute of Scientific and Technical Information of China (English)

    颜泓

    2015-01-01

    It was realized that teaching methods were only exterior factors, and what to a large extent exerted determinative effect on the learners were their inner factors.Therefore, the focus of the foreign language teaching research shifted from "how to teach" to "how to learn" and from studying "teachers" to doing research on "students".This article briefly indicates the significance of beliefs, anxiety and motivation in English learning.Thus, the author gets the implications for module advancement teaching and testing.

  13. 2015 Annual Reuse Report for the Idaho National Laboratory Site’s Advanced Test Reactor Complex Cold Waste Ponds

    Energy Technology Data Exchange (ETDEWEB)

    Lewis, Michael George [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2016-02-01

    This report describes conditions and information, as required by the state of Idaho, Department of Environmental Quality Reuse Permit I-161-02, for the Advanced Test Reactor Complex Cold Waste Ponds located at Idaho National Laboratory from November 1, 2014–October 31, 2015. The effective date of Reuse Permit I-161-02 is November 20, 2014 with an expiration date of November 19, 2019.

  14. Tensile and impact properties of vanadium-base alloys irradiated at low temperatures in the ATR-A1 experiment

    Energy Technology Data Exchange (ETDEWEB)

    Tsai, H.; Nowicki, L.J.; Billone, M.C.; Chung, H.M.; Smith, D.L. [Argonne National Lab., IL (United States)

    1998-03-01

    Subsize tensile and Charpy specimens made from several V-(4-5)Cr-(4-5)Ti alloys were irradiated in the ATR-A1 experiment to study the effects of low-temperature irradiation on mechanical properties. These specimens were contained in lithium-bonded subcapsules and irradiated at temperatures between {approx}200 and 300 C. Peak neutron damage was {approx}4.7 dpa. Postirradiation testing of these specimens has begun. Preliminary results from a limited number of specimens indicate a significant loss of work-hardening capability and dynamic toughness due to the irradiation. These results are consistent with data from previous low-temperature neutron irradiation experiments on these alloys.

  15. A hybrid original approach for prediction of the aerodynamic coefficients of an ATR-42 scaled wing model

    Institute of Scientific and Technical Information of China (English)

    Abdallah; en Mosbah; Ruxandra Mihaela; otez; Thien My; ao

    2016-01-01

    A new approach for the prediction of lift, drag, and moment coefficients is presented. This approach is based on the support vector machines (SVMs) methodology and an optimization meta-heuristic algorithm called extended great deluge (EGD). The novelty of this approach is the hybridization between the SVM and the EGD algorithm. The EGD is used to optimize the SVM parameters. The training and validation of this new identification approach is realized using the aerodynamic coefficients of an ATR-42 wing model. The aerodynamic coefficients data are obtained with the XFoil software and experimental tests using the Price–Paıdoussis wind tunnel. The predicted results with our approach are compared with those from the XFoil software and experimental results for different flight cases of angles of attack and Mach numbers. The main pur-pose of this methodology is to rapidly predict aircraft aerodynamic coefficients.

  16. A hybrid original approach for prediction of the aerodynamic coefficients of an ATR-42 scaled wing model

    Directory of Open Access Journals (Sweden)

    Abdallah Ben Mosbah

    2016-02-01

    Full Text Available A new approach for the prediction of lift, drag, and moment coefficients is presented. This approach is based on the support vector machines (SVMs methodology and an optimization meta-heuristic algorithm called extended great deluge (EGD. The novelty of this approach is the hybridization between the SVM and the EGD algorithm. The EGD is used to optimize the SVM parameters. The training and validation of this new identification approach is realized using the aerodynamic coefficients of an ATR-42 wing model. The aerodynamic coefficients data are obtained with the XFoil software and experimental tests using the Price–Païdoussis wind tunnel. The predicted results with our approach are compared with those from the XFoil software and experimental results for different flight cases of angles of attack and Mach numbers. The main purpose of this methodology is to rapidly predict aircraft aerodynamic coefficients.

  17. Improved Test Planning and Analysis Through the Use of Advanced Statistical Methods

    Science.gov (United States)

    Green, Lawrence L.; Maxwell, Katherine A.; Glass, David E.; Vaughn, Wallace L.; Barger, Weston; Cook, Mylan

    2016-01-01

    The goal of this work is, through computational simulations, to provide statistically-based evidence to convince the testing community that a distributed testing approach is superior to a clustered testing approach for most situations. For clustered testing, numerous, repeated test points are acquired at a limited number of test conditions. For distributed testing, only one or a few test points are requested at many different conditions. The statistical techniques of Analysis of Variance (ANOVA), Design of Experiments (DOE) and Response Surface Methods (RSM) are applied to enable distributed test planning, data analysis and test augmentation. The D-Optimal class of DOE is used to plan an optimally efficient single- and multi-factor test. The resulting simulated test data are analyzed via ANOVA and a parametric model is constructed using RSM. Finally, ANOVA can be used to plan a second round of testing to augment the existing data set with new data points. The use of these techniques is demonstrated through several illustrative examples. To date, many thousands of comparisons have been performed and the results strongly support the conclusion that the distributed testing approach outperforms the clustered testing approach.

  18. Advances in techniques of testing mycobacterial drug sensitivity, and the use of sensitivity tests in tuberculosis control programmes

    Science.gov (United States)

    Canetti, G.; Fox, Wallace; Khomenko, A.; Mahler, H. T.; Menon, N. K.; Mitchison, D. A.; Rist, N.; Šmelev, N. A.

    1969-01-01

    In a paper arising out of an informal international consultation of specialists in the bacteriology of tuberculosis held in 1961, an attempt was made to formulate criteria, and specify technical procedures, for reliable tests of sensitivity (the absolute-concentration method, the resistance-ratio method and the proportion method) to the 3 main antituberculosis drugs (isoniazid, streptomycin and p-aminosalicylic acid). Seven years later, a further consultation was held to review the latest developments in the field and to suggest how sensitivity tests might be put to practical use in tuberculosis control programmes. The participants reached agreement on how to define drug sensitivity and resistance, and stressed the importance of using a discrimination approach to the calibration of sensitivity tests. Their views are contained in the present paper, which also includes descriptions of the sensitivity tests used by the Medical Research Council of Great Britain for first- and second-line drugs (minimal inhibitory concentration and resistance-ratio methods), the two main variants of the proportion method developed by the Institut Pasteur, Paris, and a method for calibrating sensitivity tests. PMID:5309084

  19. Small-molecule inhibitors of Ataxia Telangiectasia and Rad3 related kinase (ATR) sensitize lymphoma cells to UVA radiation

    DEFF Research Database (Denmark)

    Biskup, Edyta; Naym, David Gram; Gniadecki, Robert

    2016-01-01

    and require more aggressive therapies. OBJECTIVE: The aim of this project was to investigate whether inhibition of Ataxia Telangiectasia and Rad3 related kinase (ATR) may enhance efficacy of phototherapy. METHODS: CTCL cell lines (MyLa2000, SeAx and Mac2a) served as in vitro cell models. ATR and Chk1 were...

  20. ATR-FTIR Spectroscopy in the Undergraduate Chemistry Laboratory: Part II--A Physical Chemistry Laboratory Experiment on Surface Adsorption

    Science.gov (United States)

    Schuttlefield, Jennifer D.; Larsen, Sarah C.; Grassian, Vicki H.

    2008-01-01

    Attenuated total reflectance-Fourier transform infrared (ATR-FTIR) spectroscopy is a useful technique for measuring the infrared spectra of solids and liquids as well as probing adsorption on particle surfaces. The use of FTIR-ATR spectroscopy in organic and inorganic chemistry laboratory courses as well as in undergraduate research was presented…

  1. Effects of atrazine (ATR), deisopropylatrazine (DIA), Diaminochlorotriazine (DACT) on the hypothalamic-pituitary-adrenal (HPA) axis in female rats

    Science.gov (United States)

    We previously reported that a single dose of the herbicide ATR stimulated the HPA axis in the male rat while equimolar doses of its primary metabolite, DACT, had a minimal effect. In this study, we evaluated the effects of one or four daily doses of ATR, DACT, and an intermediat...

  2. EFFECTS OF ATRAZINE (ATR), DEISOPROPYLATRAZINE (DIA), AND DIAMINOCHLOROTRIAZINE (DACT) ON THE HYPOTHALAMIC-PITUITARY-ADRENAL (HPA) AXIS IN FEMALE RATS

    Science.gov (United States)

    Previously we reported that a single dose of ATR herbicide stimulated HPA axis activation in the male rat while its primary metabolite, DACT, did so to a lesser extent. In this study, we evaluated the effects of ATR, DACT, and an intermediate metabolite, DIA, on adrenocorticotrop...

  3. Advanced Stirling Convertor Control Unit Testing at NASA Glenn Research Center in the Radioisotope Power Systems System Integration Laboratory

    Science.gov (United States)

    Dugala, Gina M.; Taylor, Linda M.; Kussmaul, Michael; Casciani, Michael; Brown, Gregory; Wiser, Joel

    2017-01-01

    Future NASA missions could include establishing Lunar or Martian base camps, exploring Jupiters moons and travelling beyond where generating power from sunlight may be limited. Radioisotope Power Systems (RPS) provide a dependable power source for missions where inadequate sunlight or operational requirements make other power systems impractical. Over the past decade, NASA Glenn Research Center (GRC) has been supporting the development of RPSs. The Advanced Stirling Radioisotope Generator (ASRG) utilized a pair of Advanced Stirling Convertors (ASC). While flight development of the ASRG has been cancelled, much of the technology and hardware continued development and testing to guide future activities. Specifically, a controller for the convertor(s) is an integral part of a Stirling-based RPS. For the ASRG design, the controller maintains stable operation of the convertors, regulates the alternating current produced by the linear alternator of the convertor, provides a specified direct current output voltage for the spacecraft, synchronizes the piston motion of the two convertors in order to minimize vibration as well as manage and maintain operation with a stable piston amplitude and hot end temperature. It not only provides power to the spacecraft but also must regulate convertor operation to avoid damage to internal components and maintain safe thermal conditions after fueling. Lockheed Martin Coherent Technologies has designed, developed and tested an Engineering Development Unit (EDU) Advanced Stirling Convertor Control Unit (ACU) to support this effort. GRC used the ACU EDU as part of its non-nuclear representation of a RPS which also consists of a pair of Dual Advanced Stirling Convertor Simulator (DASCS), and associated support equipment to perform a test in the Radioisotope Power Systems System Integration Laboratory (RSIL). The RSIL was designed and built to evaluate hardware utilizing RPS technology. The RSIL provides insight into the electrical

  4. First Beam and High-Gradient Cryomodule Commissioning Results of the Advanced Superconducting Test Accelerator at Fermilab

    Energy Technology Data Exchange (ETDEWEB)

    Crawford, Darren; et al.

    2015-06-01

    The advanced superconducting test accelerator at Fermilab has accelerated electrons to 20 MeV and, separately, the International Linear Collider (ILC) style 8-cavity cryomodule has achieved the ILC performance milestone of 31.5 MV/m per cavity. When fully completed, the accelerator will consist of a photoinjector, one ILC-type cryomodule, multiple accelerator R&D beamlines, and a downstream beamline to inject 300 MeV electrons into the Integrable Optics Test Accelerator (IOTA). We report on the results of first beam, the achievement of our cryomodule to ILC gradient specifications, and near-term future plans for the facility.

  5. Efficacy of metformin in human single hair fibre by ATR-FTIR spectroscopy coupled with statistical analysis.

    Science.gov (United States)

    Sundaramoorthi, Kamatchi; Sethu, Gunasekaran; Ethirajulu, Sailatha; Raja Marthandam, Pavithra

    2017-03-20

    Diabetes mellitus is chronic metabolic disorder, resulting from insulin deficiency, characterized by hyperglycemia altered metabolism of carbohydrates, proteins and lipids and an increased risk of vascular complications. There are different classes of anti-diabetic drugs in allopathic system of medicine. Metformin (dimethyl biguanide) is a blood glucose lowering agent used in the treatment of non-insulin dependent diabetes mellitus. Almost in all diseases the blood serves as the primary metabolic transport system in the body. Its composition is the preferred indicator with respect to the pathophysiological condition of the patient. Instead of analyzing blood to diagnose diabetes, hair could be used to detect diabetes using FTIR-ATR technique. The most important components of hair are fibrous proteins (keratins), melanins, glycogen, and lipids. Hair follicles are located 3-4mm below the surface of the skin and are surrounded by rich blood capillary system. In the present study, ten diabetic subjects were considered to evaluate the efficacy of metformin hydrochloride for the treatment of diabetes mellitus using FTIR-ATR spectroscopy. The spectra of diabetic hair fibre samples have been recorded in the mid infrared region of 4000-450cm(-1). The hair samples of the diabetic subjects before medication were taken as pre-treatment samples. The hair samples of diabetic subjects referred to medication with metformin for a period of three month were taken as post-treatment sample. Some remarkable spectral differences were elucidated between pre- and post-treatment hair fibre samples. A comparative study on the FTIR-ATR hair spectra of patients (pre- and post-treatment) along with the healthy subjects has been made. The absorption values of some of the specific bands of biomolecules present in the hair samples viz., protein, lipids and glucose for both the pre- and post-treatment subjects are noted. It was observed that, these biomarkers are significantly different between

  6. Design and manufacturing of non-instrumented capsule for advanced PWR fuel pellet irradiation test in HANARO

    Energy Technology Data Exchange (ETDEWEB)

    Kim, D. H.; Lee, C. B.; Song, K. W. [Korea Atomic Energy Research Institute, Taejeon (Korea)

    2002-04-01

    This project is preparing to irradiation test of the developed large grain UO{sub 2} fuel pellet in HANARO for pursuit fuel safety and high burn-up in 'Advanced LWR Fuel Technology Development Project' as a part Nuclear Mid and Long-term R and D Program. On the basis test rod is performed the nuclei property and preliminary fuel performance analysis, test rod and non-instrumented capsule are designed and manufactured for irradiation test in HANARO. This non-instrumented irradiation capsule of Advanced PWR Fuel pellet was referred the non-instrumented capsule for an irradiation test of simulated DUPIC fuel in HANARO(DUPIC Rig-001) and 18-element HANARO fuel, was designed to ensure the integrity and the endurance of non-instrumented capsule during the long term(2.5 years) irradiation. To irradiate the UO{sub 2} pellets up to the burn-up 70 MWD/kgU, need the time about 60 months and ensure the integrity of non-instrumented capsule for 30 months until replace the new capsule. This non-instrumented irradiation capsule will be based to develope the non-instrumented capsule for the more long term irradiation in HANARO. 22 refs., 13 figs., 5 tabs. (Author)

  7. DESIGN, FABRICATION, AND TESTING OF AN ADVANCED, NON-POLLUTING TURBINE DRIVE GAS GENERATOR

    Energy Technology Data Exchange (ETDEWEB)

    Unknown

    2002-03-31

    The objectives of this report period were to complete the development of the Gas Generator design, which was done; fabricate and test of the non-polluting unique power turbine drive gas Gas Generator, which has been postponed. Focus during this report period has been to complete the brazing and bonding necessary to fabricate the Gas Generator hardware, continue making preparations for fabricating and testing the Gas Generator, and continuing the fabrication of the Gas Generator hardware and ancillary hardware in preparation for the test program. Fabrication is more than 95% complete and is expected to conclude in early May 2002. the test schedule was affected by relocation of the testing to another test supplier. The target test date for hot fire testing is now not earlier than June 15, 2002.

  8. An Advanced HIL Simulation Battery Model for Battery Management System Testing

    DEFF Research Database (Denmark)

    Barreras, Jorge Varela; Fleischer, Christian; Christensen, Andreas Elkjær

    2016-01-01

    Developers and manufacturers of battery management systems (BMSs) require extensive testing of controller Hardware (HW) and Software (SW), such as analog front-end and performance of generated control code. In comparison with the tests conducted on real batteries, tests conducted on a state-of-th...

  9. Steady-state testing of an advanced solar-assisted heat pump

    Energy Technology Data Exchange (ETDEWEB)

    Catan, M.A.

    1982-06-01

    A prototype water-to-air solar assisted heat pump (SAHP) has been tested under steady state conditions. The results of the tests indicate that the nominal goal for the hardware portion of the contract was achieved and surpassed. The tests show some areas of potential improvement, which are discussed.

  10. Eddy Current, Magnetic Particle and Hardness Testing, Aviation Quality Control (Advanced): 9227.04.

    Science.gov (United States)

    Dade County Public Schools, Miami, FL.

    This unit of instruction includes the principles of eddy current, magnetic particle and hardness testing; standards used for analyzing test results; techniques of operating equipment; interpretation of indications; advantages and limitations of these methods of testing; care and calibration of equipment; and safety and work precautions. Motion…

  11. Advances in neutron radiographic techniques and applications: a method for nondestructive testing.

    Science.gov (United States)

    Berger, Harold

    2004-10-01

    A brief history of neutron radiography is presented to set the stage for a discussion of significant neutron radiographic developments and an assessment of future directions for neutron radiography. Specific advances are seen in the use of modern, high dynamic range imaging methods (image plates and flat panels) and for high contrast techniques such as phase contrast, and phase-sensitive imaging. Competition for neutron radiographic inspection may develop as these techniques offer application prospects for X-ray methods.

  12. Radar Sensor Networks: Algorithms for Waveform Design and Diversity with Application to ATR with Delay-Doppler Uncertainty

    Directory of Open Access Journals (Sweden)

    Qilian Liang

    2007-01-01

    Full Text Available Automatic target recognition (ATR in target search phase is very challenging because the target range and mobility are not yet perfectly known, which results in delay-Doppler uncertainty. In this paper, we firstly perform some theoretical studies on radar sensor network (RSN design based on linear frequency modulation (LFM waveform: (1 the conditions for waveform coexistence, (2 interferences among waveforms in RSN, (3 waveform diversity in RSN. Then we apply RSN to ATR with delay-Doppler uncertainty and propose maximum-likeihood (ML ATR algorithms for fluctuating targets and nonfluctuating targets. Simulation results show that our RSN vastly reduces the ATR error compared to a single radar system in ATR with delay-Doppler uncertainty. The proposed waveform design and diversity algorithms can also be applied to active RFID sensor networks and underwater acoustic sensor networks.

  13. Micro-Attenuated Total Reflection Fourier Transform Infrared (Micro ATR FT-IR) Spectroscopic Imaging with Variable Angles of Incidence.

    Science.gov (United States)

    Wrobel, Tomasz P; Vichi, Alessandra; Baranska, Malgorzata; Kazarian, Sergei G

    2015-10-01

    The control of the angle of incidence in attenuated total reflection (ATR) Fourier transform infrared (FT-IR) spectroscopy allows for the probing of the sample at different depths of penetration of the evanescent wave. This approach has been recently coupled with macro-imaging capability using a diamond ATR accessory. In this paper, the design of optical apertures for the micro-germanium (Ge) ATR objective is presented for an FT-IR spectroscopic imaging microscope, allowing measurements with different angles of incidence. This approach provides the possibility of three-dimensional (3D) profiling in micro-ATR FT-IR imaging mode. The proof of principle results for measurements of polymer laminate samples at different angles of incidence confirm that controlling the depth of penetration is possible using a Ge ATR objective with added apertures.

  14. Observed Changes in As-Fabricated U-10Mo Monolithic Fuel Microstructures After Irradiation in the Advanced Test Reactor

    Science.gov (United States)

    Keiser, Dennis; Jue, Jan-Fong; Miller, Brandon; Gan, Jian; Robinson, Adam; Madden, James

    2017-08-01

    A low-enriched uranium U-10Mo monolithic nuclear fuel is being developed by the Material Management and Minimization Program, earlier known as the Reduced Enrichment for Research and Test Reactors Program, for utilization in research and test reactors around the world that currently use high-enriched uranium fuels. As part of this program, reactor experiments are being performed in the Advanced Test Reactor. It must be demonstrated that this fuel type exhibits mechanical integrity, geometric stability, and predictable behavior to high powers and high fission densities in order for it to be a viable fuel for qualification. This paper provides an overview of the microstructures observed at different regions of interest in fuel plates before and after irradiation for fuel samples that have been tested. These fuel plates were fabricated using laboratory-scale fabrication methods. Observations regarding how microstructural changes during irradiation may impact fuel performance are discussed.

  15. Recent Advances in Hydrogen Peroxide Propulsion Test Capability at NASA's Stennis Space Center E-Complex

    Science.gov (United States)

    Jacks, Thomas E.; Beisler, Michele

    2003-01-01

    In recent years, the rocket propulsion test capability at NASA's John C. Stennis Space Center's (SSC) E-Complex has been enhanced to include facilitization for hydrogen peroxide (H2O2) based ground testing. In particular, the E-3 test stand has conducted numerous test projects that have been reported in the open literature. These include combustion devices as simple as small-scale catalyst beds, and larger devices such as ablative thrust chambers and a flight-type engine (AR2-3). Consequently, the NASA SSC test engineering and operations knowledge base and infrastructure have grown considerably in order to conduct safe H2O2 test operations with a variety of test articles at the component and engine level. Currently, the E-Complex has a test requirement for a hydrogen peroxide based stage test. This new development, with its unique set of requirements, has motivated the facilitization for hydrogen peroxide propellant use at the E-2 Cell 2 test position in addition to E-3. Since the E-2 Cell 2 test position was not originally designed as a hydrogen peroxide test stand, a facility modernization-improvement project was planned and implemented in FY 2002-03 to enable this vertical engine test stand to accomodate H2O2. This paper discusses the ongoing enhancement of E-Complex ground test capability, specifically at the E-3 stand (Cell 1 and Cell 2) and E-2 Cell 2 stand, that enable current and future customers considerable test flexibility and operability in conducting their peroxide based rocket R&D efforts.

  16. Advanced industrial gas turbine technology readiness demonstration program. Phase II. Final report: compressor rig fabrication assembly and test

    Energy Technology Data Exchange (ETDEWEB)

    Schweitzer, J. K.; Smith, J. D.

    1981-03-01

    The results of a component technology demonstration program to fabricate, assemble and test an advanced axial/centrifugal compressor are presented. This work was conducted to demonstrate the utilization of advanced aircraft gas turbine cooling and high pressure compressor technology to improve the performance and reliability of future industrial gas turbines. Specific objectives of the compressor component testing were to demonstrate 18:1 pressure ratio on a single spool at 90% polytropic efficiency with 80% fewer airfoils as compared to current industrial gas turbine compressors. The compressor design configuration utilizes low aspect ratio/highly-loaded axial compressor blading combined with a centrifugal backend stage to achieve the 18:1 design pressure ratio in only 7 stages and 281 axial compressor airfoils. Initial testing of the compressor test rig was conducted with a vaneless centrifugal stage diffuser to allow documentation of the axial compressor performance. Peak design speed axial compressor performance demonstrated was 91.8% polytropic efficiency at 6.5:1 pressure ratio. Subsequent documentation of the combined axial/centrifugal performance with a centrifugal stage pipe diffuser resulted in the demonstration of 91.5% polytropic efficiency and 14% stall margin at the 18:1 overall compressor design pressure ratio. The demonstrated performance not only exceeded the contract performance goals, but also represents the highest known demonstrated compressor performance in this pressure ratio and flow class. The performance demonstrated is particularly significant in that it was accomplished at airfoil loading levels approximately 15% higher than that of current production engine compressor designs. The test results provide conclusive verification of the advanced low aspect ratio axial compressor and centrifugal stage technologies utilized.

  17. Advanced Stirling Convertor Dual Convertor Controller Testing at NASA Glenn Research Center in the Radioisotope Power Systems System Integration Laboratory

    Science.gov (United States)

    Dugala, Gina M.; Taylor, Linda M.; Bell, Mark E.; Dolce, James L.; Fraeman, Martin; Frankford, David P.

    2015-01-01

    NASA Glenn Research Center developed a nonnuclear representation of a Radioisotope Power System (RPS) consisting of a pair of Advanced Stirling Convertors (ASCs), Dual Convertor Controller (DCC) EMs (engineering models) 2 and 3, and associated support equipment, which were tested in the Radioisotope Power Systems System Integration Laboratory (RSIL). The DCC was designed by the Johns Hopkins University Applied Physics Laboratory (JHU/APL) to actively control a pair of ASCs. The first phase of testing included a Dual Advanced Stirling Convertor Simulator (DASCS), which was developed by JHU/APL and simulates the operation and electrical behavior of a pair of ASCs in real time via a combination of hardware and software. RSIL provides insight into the electrical interactions between a representative radioisotope power generator, its associated control schemes, and realistic electric system loads. The first phase of integration testing included the following spacecraft bus configurations: capacitive, battery, and super-capacitor. A load profile, created based on data from several missions, tested the RPS's and RSIL's ability to maintain operation during load demands above and below the power provided by the RPS. The integration testing also confirmed the DCC's ability to disconnect from the spacecraft when the bus voltage dipped below 22 volts or exceeded 36 volts. Once operation was verified with the DASCS, the tests were repeated with actual operating ASCs. The goal of this integration testing was to verify operation of the DCC when connected to a spacecraft and to verify the functionality of the newly designed RSIL. The results of these tests are presented in this paper.

  18. ATR controls cellular adaptation to hypoxia through positive regulation of hypoxia-inducible factor 1 (HIF-1) expression.

    Science.gov (United States)

    Fallone, F; Britton, S; Nieto, L; Salles, B; Muller, C

    2013-09-12

    Tumor cells adaptation to severe oxygen deprivation (hypoxia) plays a major role in tumor progression. The transcription factor HIF-1 (hypoxia-inducible factor 1), whose α-subunit is stabilized under hypoxic conditions is a key component of this process. Recent studies showed that two members of the phosphoinositide 3-kinase-related kinases (PIKKs) family, ATM (ataxia telangiectasia mutated) and DNA-PK (DNA-dependent protein kinase), regulate the hypoxic-dependent accumulation of HIF-1. These proteins initiate cellular stress responses when DNA damage occurs. In addition, it has been demonstrated that extreme hypoxia induces a replicative stress resulting in regions of single-stranded DNA at stalled replication forks and the activation of ATR (ataxia telangiectasia and Rad3 related protein), another member of the PIKKs family. Here, we show that even less severe hypoxia (0.1% O2) also induces activation of ATR through replicative stress. Importantly, in using either transiently silenced ATR cells, cells expressing an inactive form of ATR or cells exposed to an ATR inhibitor (CGK733), we demonstrate that hypoxic ATR activation positively regulates the key transcription factor HIF-1 independently of the checkpoint kinase Chk1. We show that ATR kinase activity regulates HIF-1α at the translational level and we find that the elements necessary for the regulation of HIF-1α translation are located within the coding region of HIF-1α mRNA. Finally, by using three independent cellular models, we clearly show that the loss of ATR expression and/or kinase activity results in the decrease of HIF-1 DNA binding under hypoxia and consequently affects protein expression levels of two HIF-1 target genes, GLUT-1 and CAIX. Taken together, our data show a new function for ATR in cellular adaptation to hypoxia through regulation of HIF-1α translation. Our work offers new prospect for cancer therapy using ATR inhibitors with the potential to decrease cellular adaptation in hypoxic

  19. Surface modification of nano-silica on the ligament advanced reinforcement system for accelerated bone formation: primary human osteoblasts testing in vitro and animal testing in vivo.

    Science.gov (United States)

    Li, Mengmeng; Wang, Shiwen; Jiang, Jia; Sun, Jiashu; Li, Yuzhuo; Huang, Deyong; Long, Yun-Ze; Zheng, Wenfu; Chen, Shiyi; Jiang, Xingyu

    2015-05-07

    The Ligament Advanced Reinforcement System (LARS) has been considered as a promising graft for ligament reconstruction. To improve its biocompatibility and effectiveness on new bone formation, we modified the surface of a polyethylene terephthalate (PET) ligament with nanoscale silica using atom transfer radical polymerization (ATRP) and silica polymerization. The modified ligament is tested by both in vitro and in vivo experiments. Human osteoblast testing in vitro exhibits an ∼21% higher value in cell viability for silica-modified grafts compared with original grafts. Animal testing in vivo shows that there is new formed bone in the case of a nanoscale silica-coated ligament. These results demonstrate that our approach for nanoscale silica surface modification on LARS could be potentially applied for ligament reconstruction.

  20. Advances in VLSI testing at MultiGb per second rates

    Directory of Open Access Journals (Sweden)

    Topisirović Dragan

    2005-01-01

    Full Text Available Today's high performance manufacturing of digital systems requires VLSI testing at speeds of multigigabits per second (multiGbps. Testing at Gbps needs high transfer rates among channels and functional units, and requires readdressing of data format and communication within a serial mode. This implies that a physical phenomena-jitter, is becoming very essential to tester operation. This establishes functional and design shift, which in turn dictates a corresponding shift in test and DFT (Design for Testability methods. We, here, review various approaches and discuss the tradeoffs in testing actual devices. For industry, volume-production stage and testing of multigigahertz have economic challenges. A particular solution based on the conventional ATE (Automated Test Equipment resources, that will be discussed, allows for accurate testing of ICs with many channels and this systems can test ICs at 2.5 Gbps over 144 cannels, with extensions planned that will have test rates exceeding 5 Gbps. Yield improvement requires understanding failures and identifying potential sources of yield loss. This text focuses on diagnosing of random logic circuits and classifying faults. An interesting scan-based diagnosis flow, which leverages the ATPG (Automatic Test Pattern Generator patterns originally generated for fault coverage, will be described. This flow shows an adequate link between the design automation tools and the testers, and a correlation between the ATPG patterns and the tester failure reports.

  1. Developing of a software for determining advanced brake failures in brakes test bench

    Directory of Open Access Journals (Sweden)

    Hakan Köylü

    2016-08-01

    Full Text Available At present time, the brake test bench conducts the braking and suspension tests of front or rear axles and the test results are evaluated through one axle. The purpose of the brake testing system is to determine braking force and damping coefficient dissymmetry of one axle. Thus, this test system evaluates the performance of service brake, hand brake and suspension systems by considering separately front and rear axle dissymmetry. For this reason, the effects of different braking and damping forces applied by right and left wheels of both axles on braking performance of all vehicle are not determined due to available algorithm of the test bench. Also, the other brake failures are not occurred due to the algorithm of brake test system. In this study, the interface has been developed to determine the other effects of dissymmetry and the other brake failures by using the one axle results of brake test bench. The interface has algorithm computing the parameters according to the interaction between front and rear axles by only using measured test results. Also, it gives the warnings by comparing changes in the parameters with braking performance rules. Braking and suspension tests of three different vehicles have been conducted by using brake test bench to determine the performance of the algorithm. Parameters based on the axle interaction have been calculated by transferring brake test results to the interface and the test results have been evaluated. As a result, the effects of brake and suspension failures on braking performance of both axle and vehicle have been determined thanks to the developed interface.

  2. Measured thermal and fast neutron fluence rates for ATF-1 holders during ATR cycle 160A

    Energy Technology Data Exchange (ETDEWEB)

    Walker, B. J. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Miller, D. T. [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2017-06-06

    This report contains the thermal (2200 m/s) and fast (E>1MeV) neutron fluence rate data for the ATF-1 holders located in core for ATR Cycle 160A which were measured by the Radiation Measurements Laboratory (RML).

  3. An add-on system including a micro-reactor for an atr-ir spectrometer

    DEFF Research Database (Denmark)

    2014-01-01

    The invention relates to an add-on system for an attenuated total reflectance infrared (ATR-IR) spectrometer, the add-on system allowing for time-resolved in situ IR measurements of heterogeneous mixtures. The add-on device comprises a micro-reactor (300A) forming a sample cavity (305) when...

  4. An add-on system for photochemical ATR-IR spectroscopy studies

    DEFF Research Database (Denmark)

    2014-01-01

    The invention relates to an add-on system for a unit mainly adapted for attenuated total reflectance infrared (ATR-IR) spectroscopy. The add-on system enables time-resolved in-situ measurements of different sample types in an easy, simple and inexpensive way. The add-on system includes a cap (300G...

  5. MATERNAL ATRAZINE (ATR) ALTERS HYPOTHALAMIC DOPAMINE (HYP-DA) AND SERUM PROLACTIN (SPRL) IN MALE PUPS

    Science.gov (United States)

    Maternal Atrazine (ATR) alters hypothalamic dopamine (HYP-DA) and serum prolactin (sPRL) in male pups. 1Christopher Langdale, 2Tammy Stoker and 2Ralph Cooper. 1 Dept. of Cell Biology, North Carolina State University College of Veterinary Medicine, Raleigh, NC. 2 Endocrinology ...

  6. Solid Acid-Catalyzed Cellulose Hydrolysis Monitored by In Situ ATR-IR Spectroscopy

    NARCIS (Netherlands)

    Zakzeski, J.|info:eu-repo/dai/nl/326160256; Grisel, R.J.H.; Smit, A.T.; Weckhuysen, B.M.|info:eu-repo/dai/nl/285484397

    2012-01-01

    The solid acid-catalyzed hydrolysis of cellulose was studied under elevated temperatures and autogenous pressures using in situ ATR-IR spectroscopy. Standards of cellulose and pure reaction products, which include glucose, fructose, hydroxymethylfurfural (HMF), levulinic acid (LA), formic acid, and

  7. Differential effect of schisandrin B stereoisomers on ATR-mediated DNA damage checkpoint signaling.

    Science.gov (United States)

    Tatewaki, Naoto; Nishida, Hiroshi; Yoshida, Masaaki; Ando, Hidehiro; Kondo, Seizo; Sakamaki, Toshiyuki; Konishi, Tetsuya

    2013-01-01

    We have previously reported that schisandrin B (SchB) is a specific inhibitor of ATR (ataxia telangiectasia and Rad-3-related) protein kinase. Since SchB consists of a mixture of its diastereomers gomisin N (GN) and γ-schisandrin (γ-Sch), the inhibitory action of SchB might result from a stereospecific interaction between one of the stereoisomers of SchB and ATR. Therefore, we investigated the effect of GN and γ-Sch on UV (UVC at 254 nm)-induced activation of DNA damage checkpoint signaling in A549 cells. UV-induced cell death (25 - 75 J/m(2)) was amplified by the presence of the diastereomers, especially GN. At the same time, GN, but not γ-Sch, inhibited the phosphorylation of checkpoint proteins such as p53, structural maintenance of chromosomes 1, and checkpoint kinase 1 in UV-irradiated cells. Moreover, GN inhibited the G2/M checkpoint during UV-induced DNA damage. The in vitro kinase activity of immunoaffinity-purified ATR was dose-dependently inhibited by GN (IC50: 7.28 μM) but not by γ-Sch. These results indicate that GN is the active component of SchB and suggest that GN inhibits the DNA damage checkpoint signaling by stereospecifically interacting with ATR.

  8. Nanocrystalline diamond sensor targeted for selective CRP detection: an ATR-FTIR spectroscopy study.

    Science.gov (United States)

    Andersson, Per Ola; Viberg, Pernilla; Forsberg, Pontus; Nikolajeff, Fredrik; Österlund, Lars; Karlsson, Mikael

    2016-05-01

    Protein immobilization on functionalized fluorine-terminated nanocrystalline (NCD) films was studied by attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopy using an immobilization protocol developed to specifically bind C-reactive protein (CRP). Using an ATR-FTIR spectroscopy method employing a force-controlled anvil-type configuration, three critical steps of the ex situ CRP immobilization were analyzed. First, the NCD surface was passivated by deposition of a copolymer layer consisting of polyethylene oxide and polypropylene oxide. Second, a synthetic modified polypeptide binder with high affinity to CRP was covalently attached to the polymeric film. Third, CRP dissolved in aqueous buffer in concentrations of 10-20 μg/mL was added on the functionalized NCD surface. Both the amide I and II bands, due to the polypeptide binder and CRP, were clearly observed in ATR-FTIR spectra. CRP amide I bands were extracted from difference spectra and yielded bands that agreed well with the reported amide I band of free (non-bonded) CRP in solution. Thus, our results show that CRP retains its secondary structure when it is attached to the polypeptide binders. Compared to previous IR studies of CRP in solution, about 200 times lower concentration was applied in the present study. Graphical Abstract Direct non-destructive ATR-FTIR analysis of C-reactive protein (CRP) selectively bound to functionalized nanocrystalline diamond (NCD) sensor surface.

  9. Transfer of polarized 3He ions in the AtR beam transfer line

    Energy Technology Data Exchange (ETDEWEB)

    Tsoupas N.; MacKay, W.W.; Meot, F.; Roser, T.; Trbojevic, D.

    2012-05-20

    In addition to collisions of electrons with various unpolarized ion species as well as polarized protons, the proposed electron-hadron collider (eRHIC) will facilitate the collisions of electrons with polarized {sup 3}He ions. The AGS is the last acceleration stage, before injection into one of the RHIC's collider ring for final acceleration. The AtR (AGS to RHIC) transfer line will be utilized to transport the polarized {sup 3}He ions from AGS into one of the RHIC's collider rings. Some of the peculiarities of the AtR line's layout (simultaneous horizontal and vertical bends) may degrade the matching of the stable spin direction of the AtR line with that of RHIC's. In this paper we discuss possible simple modifications of the AtR line to accomplish a perfect matching of the stable spin direction of the injected {sup 3}He beam with the stable spin direction at the injection point of RHIC.

  10. Differential retention of emulsion components in the mouth after swallowing: ATR FTIR measurements of oral coatings

    NARCIS (Netherlands)

    Jongh, H.de; Janssen, A.; Weenen, H.

    2006-01-01

    ATR FT-IR spectroscopy was used to investigate the coating that stays behind in the moutii after swallowing mayonnaise samples. Typically, the oil content was found to decrease to an average of 26% (range: 12-40%) of me t=0 value after 2 min, to <13% after 4 min and had practically disappeared from

  11. An in situ ATR-IR spectroscopy study of aluminas under aqueous phase reforming conditions

    NARCIS (Netherlands)

    Koichumanova, Kamila; Gupta, K.B. Sai Sankar; Lefferts, Leonardus; Mojet, Barbara; Seshan, Kulathuiyer

    2015-01-01

    High temperature/pressure in situ Attenuated Total Reflection Infrared (ATR-IR) spectroscopy was used to investigate the phase transformation of support γ-Al2O3 into boehmite (AlO(OH)) under the hydrothermal conditions of aqueous phase reforming (APR). Activation energy barriers of boehmite

  12. Potentiation of tumor responses to DNA damaging therapy by the selective ATR inhibitor VX-970.

    Science.gov (United States)

    Hall, Amy B; Newsome, Dave; Wang, Yuxin; Boucher, Diane M; Eustace, Brenda; Gu, Yong; Hare, Brian; Johnson, Mac A; Milton, Sean; Murphy, Cheryl E; Takemoto, Darin; Tolman, Crystal; Wood, Mark; Charlton, Peter; Charrier, Jean-Damien; Furey, Brinley; Golec, Julian; Reaper, Philip M; Pollard, John R

    2014-07-30

    Platinum-based DNA-damaging chemotherapy is standard-of-care for most patients with lung cancer but outcomes remain poor. This has been attributed, in part, to the highly effective repair network known as the DNA-damage response (DDR). ATR kinase is a critical regulator of this pathway, and its inhibition has been shown to sensitize some cancer, but not normal, cells in vitro to DNA damaging agents. However, there are limited in vivo proof-of-concept data for ATR inhibition. To address this we profiled VX-970, the first clinical ATR inhibitor, in a series of in vitro and in vivo lung cancer models and compared it with an inhibitor of the downstream kinase Chk1. VX-970 markedly sensitized a large proportion of a lung cancer cell line and primary tumor panel in vitro to multiple DNA damaging drugs with clear differences to Chk1 inhibition observed. In vivo VX-970 blocked ATR activity in tumors and dramatically enhanced the efficacy of cisplatin across a panel of patient derived primary lung xenografts. The combination led to complete tumor growth inhibition in three cisplatin-insensitive models and durable tumor regression in a cisplatin-sensitive model. These data provide a strong rationale for the clinical evaluation of VX-970 in lung cancer patients.

  13. Toughness testing and high-temperature oxidation evaluations of advanced alloys for core internals

    Energy Technology Data Exchange (ETDEWEB)

    Tan, Lizhen [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Pint, Bruce A. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Chen, Xiang [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2016-09-16

    Alloy X-750 was procured from Carpenter Technology and Bodycote in this year. An appropriate TMT was developed on Alloy 439 to obtain materials with refined grain size for property screening tests. Charpy V-notch impact tests were completed for the three ferritic steels Grade 92, Alloy 439, and 14YWT. Fracture toughness tests at elevated temperatures were completed for 14YWT. The tests will be completed for the other alloys in next fiscal year. Steam oxidation tests of the three ferritic steels, 316L, and Zr–2.5Nb have been completed. The steam tests of the Ni-based superalloys and the other austenitic stainless steels will be continued and finished in next fiscal year. Performance ranking in terms of steam oxidation resistance and impact/fracture toughness of the alloys will be deduced.

  14. Toughness testing and high-temperature oxidation evaluations of advanced alloys for core internals

    Energy Technology Data Exchange (ETDEWEB)

    Tan, Lizhen [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Pint, Bruce A. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Chen, Xiang [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2016-09-16

    In summary, Alloy X-750 was procured from Carpenter Technology and Bodycote in this year. An appropriate TMT was developed on Alloy 439 to obtain materials with refined grain size for property screening tests. Charpy V-notch impact tests were completed for the three ferritic steels Grade 92, Alloy 439, and 14YWT. Fracture toughness tests at elevated temperatures were completed for 14YWT. The tests will be completed for the other alloys in next fiscal year. Steam oxidation tests of the three ferritic steels, 316L, and Zr–2.5Nb have been completed. The steam tests of the Ni-based superalloys and the other austenitic stainless steels will be continued and finished in next fiscal year. Performance ranking in terms of steam oxidation resistance and impact/fracture toughness of the alloys will be deduced.

  15. DESIGN, FABRICATION, AND TESTING OF AN ADVANCED, NON-POLLUTING TURBINE DRIVE GAS GENERATOR

    Energy Technology Data Exchange (ETDEWEB)

    Stephen E. Doyle

    2002-12-31

    The objectives of this report period were to continue and complete testing of the Gas Generator hardware, to complete and submit a Draft Final Report, and after incorporation of adjustments required, to then submit the Final Report. Focus during this report period was initially on testing the Gas Generator. While conducting scheduled full power tests of the Gas Generator at the facilities of the testing sub-contractor, National Testing Services [NTS], in Santa Clarita CA, anomalies in the performance of the Gas Generator were discovered. All testing was stopped on November 6, 2002. An expert team was formed to evaluate the anomalies and to recommend any appropriate corrective actions. After extensive analyses of the actual hardware, the test data acquired and recorded during testing, and a review of the test facilities and procedures, the Anomalies Review Team recommended that CES modify the combustion chamber front end cooling method and modify the configuration of the diluent injectors downstream of the combustion chamber, to eliminate the anomalies. At a review meeting convened in Sacramento CA on November 23, 2002, outside experts from the Lawrence Livermore National Laboratory, Air Liquide's Research Center in Chicago IL, and the California Energy Commission, confirmed that the expert team's assessed cause of the problem was the likely cause, and the recommended corrective actions were appropriate. Modified hardware drawings were produced in late November-early December 2002, hardware fabrication was begun in December, and was in process at the end of December. Also during December, the NTS test facility was being adjusted to take account of the modified hardware configuration being produced. All work was aimed toward realizing a schedule of resumed testing by mid-January for completion of tests by end of January or early February, 2003. Original objectives of the program remain in place and approximately ninety (90) percent of those objectives had

  16. 78 FR 19691 - Applications for New Awards; Advanced Placement (AP) Test Fee Program

    Science.gov (United States)

    2013-04-02

    ... also requires various assurances including those applicable to Federal civil rights laws that prohibit... tests taken by minority (Hispanic, Black, Native American) public school students nationally; (3)...

  17. Advanced Test Method of Solid Oxide Cells in a Plug-Flow Setup

    DEFF Research Database (Denmark)

    Jensen, Søren Højgaard; Hauch, Anne; Hendriksen, Peter Vang;

    2009-01-01

    This paper describes a case study of two electrolysis tests of solid oxide cells [Ni/yttria-stabilized zirconia (YSZ)-YSZ-lanthanum strontium manganite (LSM)/YSZ] tested in a plug-flow setup. An extensively instrumented cell test setup was used, and the tests involved measurements of the cell...... electrolysis conditions. From measurements of the in-plane voltages in the electrodes and impedance spectra obtained during the electrolysis operation, we derive information about the resistance distributions in the Ni electrodes and describe how these distributions evolve over time. Impedance spectra at open...

  18. Testing an intervention to improve functional capability in advanced cardiopulmonary illness.

    Science.gov (United States)

    Dougherty, Cynthia M; Steele, Bonnie G; Hunziker, Jim

    2011-01-01

    The development of a conceptually driven exercise and self-management intervention for improving functional capability and reducing health care costs using social cognitive theory is described. The intervention has 2 components: a 1-month outpatient exercise intervention followed by a home component, lasting 5 months. The intervention is expected to have significant impact on daily function, quality of life, gait/balance, self-efficacy, and health care utilization in persons with advanced heart failure or chronic obstructive pulmonary disease. We report preliminary results related to process-related variables, including feasibility, safety, and intervention adherence. Intervention outcomes are currently under study and will be reported when available.

  19. ATR-FT/IR study on the interactions between gliadins and dextrin and their effects on protein secondary structure.

    Science.gov (United States)

    Secundo, Francesco; Guerrieri, Nicoletta

    2005-03-09

    The effects of heat treatment and dextrin addition on the secondary structure of gliadins were investigated by means of attenuated total reflection Fourier transform infrared spectroscopy (ATR-FT/IR). Gliadins and gliadin/dextrin mixtures (before and after thermal treatment) were prepared as a dried protein film on the ATR-FT/IR zinc selenide cell plate and equilibrated at a water activity (a(w)) of 0.06. The results show that gliadins undergo conformational changes upon thermal treatment both in the absence and in the presence of dextrin. In particular, in the thermally treated gliadins, the decrease of the band at around 1651 cm(-)(1) and the increase of the bands at around 1628 and 1690 cm(-)(1) suggest a loss of alpha-helix structure and a higher content of protein aggregates. The same trend was observed in the presence of dextrin. Concerning the interactions between gliadins and dextrin, gliadin/dextrin mixtures show variations in the amide I region compared to native gliadins (e.g., an increase of the band at 1645 cm(-)(1) and the absence of the band at around 1668 cm(-)(1)) that might be due to hydrogen bond formation between gliadins and dextrin. It was also found that the spectrum of gliadin/dextrin mixtures was less affected by the hydration state than that of native gliadins, as observed from the differential spectra obtained by subtraction of the spectrum obtained at a(w) = 0.06 (driest condition tested) from the spectrum of the sample equilibrated at a(w) = 0.84. This could be due to the fact that C=O and N-H groups of gliadins are engaged to form hydrogen bonds with the hydroxyl groups of dextrin, and so they are not perturbed by the presence of water molecules. Finally, water activity effects on the secondary structure of gliadins are also discussed.

  20. The ABC transporter AtrB from Aspergillus nidulans is involved in resistance to all major classes of fungicides and natural toxic compounds

    NARCIS (Netherlands)

    Andrade, A.C.; Del Sorbo, G.; Nistelrooy, van J.G.M.; Waard, de M.A.

    2000-01-01

    This paper reports the functional characterization of AtrBp, an ABC transporter from Aspergillus nidulans. AtrBp is a multidrug transporter and has affinity to substrates belonging to all major classes of agricultural fungicides and some natural toxic compounds. The substrate profile of AtrBp was de

  1. 75 FR 15443 - Advancing the Development of Diagnostic Tests and Biomarkers for Tuberculosis; Public Workshop...

    Science.gov (United States)

    2010-03-29

    ...-resistant TB (MDR TB) and extensively drug-resistant TB (XDR TB). Both plans addressed domestic and global... of Diagnostic Tests and Biomarkers for Tuberculosis (TB).'' The purpose of the workshop is to provide... and procedural gaps in the current development of TB diagnostic tests, and in exploring models...

  2. Laboratory Test of Vending Machine with Advanced Defrosting Technology and Integrated Accumulatory/Expander Concept

    Energy Technology Data Exchange (ETDEWEB)

    Bryne, M E; Domitrovic, R E; Mei, V C; Chen, F C; Fransson, J H.M.

    2000-10-01

    The manufacturer delivered an off-the-shelf soft drink vending machine for testing to ORNL. The machine was tested for baseline performance and it was found that the cold air passage was not properly designed. An inadequate cold air supply to the product resulted in recirculation of the evaporator air and heavy frost accumulation on the evaporator coil.

  3. AGR-2 Data Qualification Report for ATR Cycles 151B-2, 152A, 152B, 153A, 153B and 154A

    Energy Technology Data Exchange (ETDEWEB)

    Binh T. Pham; Jeffrey J. Einerson

    2013-09-01

    This report documents the data qualification status of AGR-2 fuel irradiation experimental data from Advanced Test Reactor (ATR) Cycles 152A, 152B, 153A, 153B, and 154A, as recorded in the Nuclear Data Management and Analysis System (NDMAS). The AGR-2 data streams addressed include thermocouple (TC) temperatures, sweep gas data (flow rate, pressure, and moisture content), and fission product monitoring system (FPMS) data for each of the six capsules in the experiment. A total of 13,400,520 every minute instantaneous TC and sweep gas data records were received and processed by NDMAS for this period. Of these data, 8,911,791 records (66.5% of the total) were determined to be Qualified based on NDMAS accuracy testing and data validity assessment. For temperature, there were 4,266,081 records (74% of the total TC data) that were Failed due to TC instrument failures. For sweep gas flows, there were 222,648 gas flow records (2.91% of the flow data) that were Failed. The inlet gas flow failures due to gas flow cross-talk and leakage problems that occurred after Cycle 150A were corrected by using the same gas mixture in all six capsules and the Leadout. For FPMS data, NDMAS received and processed preliminary release rate and release-to-birth rate ratio (R/B) data for three reactor cycles (Cycles 149B, 150B, and 151A) . This data consists of 45,983 release rate records and 45,235 R/B records for the 12 radionuclides reported. The qualification status of these FPMS data has been set to In Process until receipt of Quality Assurance-approved data generator reports. All of the above data have been processed and tested using a SAS®-based enterprise application software system, stored in a secure Structured Query Language database, made available on the NDMAS Web portal (http://ndmas.inl.gov), and approved by the INL STIM for release to both internal and appropriate external Very High Temperature Reactor Program participants.

  4. Advanced contrast nanoagents for photoacoustic molecular imaging, cytometry, blood test and photothermal theranostics.

    Science.gov (United States)

    de la Zerda, Adam; Kim, Jin-Woo; Galanzha, Ekaterina I; Gambhir, Sanjiv S; Zharov, Vladimir P

    2011-01-01

    Various nanoparticles have raised significant interest over the past decades for their unique physical and optical properties and biological utilities. Here we summarize the vast applications of advanced nanoparticles with a focus on carbon nanotube (CNT)-based or CNT-catalyzed contrast agents for photoacoustic (PA) imaging, cytometry and theranostics applications based on the photothermal (PT) effect. We briefly review the safety and potential toxicity of the PA/PT contrast nanoagents, while showing how the physical properties as well as multiple biological coatings change their toxicity profiles and contrasts. We provide general guidelines needed for the validation of a new molecular imaging agent in living subjects, and exemplify these guidelines with single-walled CNTs targeted to α(v) β(3) , an integrin associated with tumor angiogenesis, and golden carbon nanotubes targeted to LYVE-1, endothelial lymphatic receptors. An extensive review of the potential applications of advanced contrast agents is provided, including imaging of static targets such as tumor angiogenesis receptors, in vivo cytometry of dynamic targets such as circulating tumor cells and nanoparticles in blood, lymph, bones and plants, methods to enhance the PA and PT effects with transient and stationary bubble conjugates, PT/PA Raman imaging and multispectral histology. Finally, theranostic applications are reviewed, including the nanophotothermolysis of individual tumor cells and bacteria with clustered nanoparticles, nanothrombolysis of blood clots, detection and purging metastasis in sentinel lymph nodes, spectral hole burning and multiplex therapy with ultrasharp rainbow nanoparticles.

  5. Development of Micro Air Reconnaissance Vehicle as a Test Bed for Advanced Sensors and Electronics

    Science.gov (United States)

    Shams, Qamar A.; Vranas, Thomas L.; Fox, Robert L.; Kuhn, Theodore R.; Ingham, John; Logan, Michael J.; Barnes, Kevin N.; Guenther, Benjamin F.

    2002-01-01

    This paper describes the development of a Micro/Mini Air Reconnaissance Vehicle for advanced sensors and electronics at NASA Langley Research Center over the last year. This vehicle is expected to have a total weight of less than four pounds, a design velocity of 40 mph, an endurance of 15-20 minutes, and a maximum range of 5km. The vehicle has wings that are simple to detach yet retain the correct alignment. The upper fuselage surface has a quick release hatch used to access the interior and also to mount the varying propulsion systems. The sensor suite developed for this vehicle consists of a Pitot-static measurement system for determining air speed, an absolute pressure measurement for determining altitude, magnetic direction measurement, and three orthogonal gyros to determine body angular rates. Swarming GPS-guidance and in-flight maneuvering is discussed, as well as design and installation of some other advance sensors like MEMS microphones, infrared cameras, GPS, humidity sensors, and an ultrasonic sonar sensor. Also low cost, small size, high performance control and navigation system for the Micro Air Vehicle is discussed. At the end, laboratory characterization of different sensors, motors, propellers, and batteries will be discussed.

  6. Science and Technology of Reactor——Brief Introduction to the Research Program of In-pile Irradiation Test for Advanced Process UO2 Pellets

    Institute of Scientific and Technical Information of China (English)

    ZHANGPei-sheng; WANGHua-rong

    2003-01-01

    In order to develop advanced PWR fuel assembly it is of great importance to carry out in-pile irradiation test UO2 PWR pellets manufactured with advanced process.A research program of the in-pile irradiation test has been planned.The main contents of the program are;1)to develop in-pile testing facility cooled directly by primary coolant in research reactor;2)to design thin fuel element.

  7. Cost-effectiveness of MODY genetic testing: translating genomic advances into practical health applications.

    Science.gov (United States)

    Naylor, Rochelle N; John, Priya M; Winn, Aaron N; Carmody, David; Greeley, Siri Atma W; Philipson, Louis H; Bell, Graeme I; Huang, Elbert S

    2014-01-01

    OBJECTIVE To evaluate the cost-effectiveness of a genetic testing policy for HNF1A-, HNF4A-, and GCK-MODY in a hypothetical cohort of type 2 diabetic patients 25-40 years old with a MODY prevalence of 2%. RESEARCH DESIGN AND METHODS We used a simulation model of type 2 diabetes complications based on UK Prospective Diabetes Study data, modified to account for the natural history of disease by genetic subtype to compare a policy of genetic testing at diabetes diagnosis versus a policy of no testing. Under the screening policy, successful sulfonylurea treatment of HNF1A-MODY and HNF4A-MODY was modeled to produce a glycosylated hemoglobin reduction of -1.5% compared with usual care. GCK-MODY received no therapy. Main outcome measures were costs and quality-adjusted life years (QALYs) based on lifetime risk of complications and treatments, expressed as the incremental cost-effectiveness ratio (ICER) (USD/QALY). RESULTS The testing policy yielded an average gain of 0.012 QALYs and resulted in an ICER of 205,000 USD. Sensitivity analysis showed that if the MODY prevalence was 6%, the ICER would be ~50,000 USD. If MODY prevalence was >30%, the testing policy was cost saving. Reducing genetic testing costs to 700 USD also resulted in an ICER of ~50,000 USD. CONCLUSIONS Our simulated model suggests that a policy of testing for MODY in selected populations is cost-effective for the U.S. based on contemporary ICER thresholds. Higher prevalence of MODY in the tested population or decreased testing costs would enhance cost-effectiveness. Our results make a compelling argument for routine coverage of genetic testing in patients with high clinical suspicion of MODY.

  8. DNA-PKcs, ATM, and ATR Interplay Maintains Genome Integrity during Neurogenesis.

    Science.gov (United States)

    Enriquez-Rios, Vanessa; Dumitrache, Lavinia C; Downing, Susanna M; Li, Yang; Brown, Eric J; Russell, Helen R; McKinnon, Peter J

    2017-01-25

    The DNA damage response (DDR) orchestrates a network of cellular processes that integrates cell-cycle control and DNA repair or apoptosis, which serves to maintain genome stability. DNA-PKcs (the catalytic subunit of the DNA-dependent kinase, encoded by PRKDC), ATM (ataxia telangiectasia, mutated), and ATR (ATM and Rad3-related) are related PI3K-like protein kinases and central regulators of the DDR. Defects in these kinases have been linked to neurodegenerative or neurodevelopmental syndromes. In all cases, the key neuroprotective function of these kinases is uncertain. It also remains unclear how interactions between the three DNA damage-responsive kinases coordinate genome stability, particularly in a physiological context. Here, we used a genetic approach to identify the neural function of DNA-PKcs and the interplay between ATM and ATR during neurogenesis. We found that DNA-PKcs loss in the mouse sensitized neuronal progenitors to apoptosis after ionizing radiation because of excessive DNA damage. DNA-PKcs was also required to prevent endogenous DNA damage accumulation throughout the adult brain. In contrast, ATR coordinated the DDR during neurogenesis to direct apoptosis in cycling neural progenitors, whereas ATM regulated apoptosis in both proliferative and noncycling cells. We also found that ATR controls a DNA damage-induced G2/M checkpoint in cortical progenitors, independent of ATM and DNA-PKcs. These nonoverlapping roles were further confirmed via sustained murine embryonic or cortical development after all three kinases were simultaneously inactivated. Thus, our results illustrate how DNA-PKcs, ATM, and ATR have unique and essential roles during the DDR, collectively ensuring comprehensive genome maintenance in the nervous system.

  9. Protein phosphatase 5 is necessary for ATR-mediated DNA repair

    Energy Technology Data Exchange (ETDEWEB)

    Kang, Yoonsung [Department of Pharmacology, DNA Repair Research Center, Chosun University School of Medicine, 375 Seosuk-Dong, Gwangju 501-759 (Korea, Republic of); Cheong, Hyang-Min [Department of Life Science, College of Natural Science, Chung-Ang University, 221 Heuksuk-Dong, Dongjak-Ku, Seoul 156-756 (Korea, Republic of); Lee, Jung-Hee [Department of Pharmacology, DNA Repair Research Center, Chosun University School of Medicine, 375 Seosuk-Dong, Gwangju 501-759 (Korea, Republic of); Song, Peter I. [Department of Dermatology, University of Arkansas for Medical Science, 4301 West Markham, Slot 576, Little Rock, AR 72205 (Korea, Republic of); Lee, Kwang-Ho [Department of Life Science, College of Natural Science, Chung-Ang University, 221 Heuksuk-Dong, Dongjak-Ku, Seoul 156-756 (Korea, Republic of); Kim, Sang-Yong [Division of Endocrinology, Department of Internal Medicine, Chosun University School of Medicine, 375 Seosuk-Dong, Gwangju 501-759 (Korea, Republic of); Jun, Jae Yeoul [Department of Physiology, Chosun University School of Medicine, 375 Seosuk-Dong, Gwangju 501-759 (Korea, Republic of); You, Ho Jin, E-mail: hjyou@chosun.ac.kr [Department of Pharmacology, DNA Repair Research Center, Chosun University School of Medicine, 375 Seosuk-Dong, Gwangju 501-759 (Korea, Republic of)

    2011-01-07

    Research highlights: {yields} Serine/threonine protein phosphatase 5 (PP5) has been shown to participate in ataxia telangiectasia-mutated (ATM)- and ATR (ATM- and Rad3-related)-mediated checkpoint pathways, which plays an important role in the DNA damage response and maintenance of genomic stability. {yields} However, it is not clear exactly how PP5 participates in this process. {yields} Our results indicate that PP5 is more closely related with ATR-mediated pathway than ATM-mediated pathway in DNA damage repair. -- Abstract: Several recent studies have shown that protein phosphatase 5 (PP5) participates in cell cycle arrest after DNA damage, but its roles in DNA repair have not yet been fully characterized. We investigated the roles of PP5 in the repair of ultraviolet (UV)- and neocarzinostatin (NCS)-induced DNA damage. The results of comet assays revealed different repair patterns in UV- and NCS-exposed U2OS-PS cells. PP5 is only essential for Rad3-related (ATR)-mediated DNA repair. Furthermore, the phosphorylation of 53BP1 and BRCA1, important mediators of DNA damage repair, and substrates of ATR and ATM decreased in U2OS-PS cells exposed to UV radiation. In contrast, the cell cycle arrest proteins p53, CHK1, and CHK2 were normally phosphorylated in U2OS and U2OS-PS cells exposed to UV radiation or treated with NCS. In view of these results, we suggest that PP5 plays a crucial role in ATR-mediated repair of UV-induced DNA damage.

  10. HEAPA Filter Bank In-Place Leak Test for ACUs of Advanced Fuel Science Building in 2010

    Energy Technology Data Exchange (ETDEWEB)

    Ji, Chul Goo; Bae, Sang Oh [KAERI, Daejeon (Korea, Republic of)

    2010-12-15

    Air cleaning units installed in the Advanced Fuel Science Building were performed visual inspection, airflow capacity test, and HEAPA filter bank in-place leak test in accordance with ASME N-510-1989. All the above inspections was acceptable. Visual inspection was satisfied to AUC-556 and AUC-557. Airflow capacity was 96%(30,240 m{sup 3}/h) of design airflow capacity(31,500 m{sup 3}/h) for AUC-556 and was 97%(22,800 m{sup 3}/h) of design airflow capacity(22,800 m{sup 3}/h) for AUC-557, and was maintained within {+-}10% of the specified value. Penetration of HEAPA filter bank in-place leak test was 0.009% for AUC-556 and was 0.013% for AUC-557 and these values were maintained less than the acceptance criteria(0.05%)

  11. Noninvasive Fetal Trisomy (NIFTY test: an advanced noninvasive prenatal diagnosis methodology for fetal autosomal and sex chromosomal aneuploidies

    Directory of Open Access Journals (Sweden)

    Jiang Fuman

    2012-12-01

    Full Text Available Abstract Background Conventional prenatal screening tests, such as maternal serum tests and ultrasound scan, have limited resolution and accuracy. Methods We developed an advanced noninvasive prenatal diagnosis method based on massively parallel sequencing. The Noninvasive Fetal Trisomy (NIFTY test, combines an optimized Student’s t-test with a locally weighted polynomial regression and binary hypotheses. We applied the NIFTY test to 903 pregnancies and compared the diagnostic results with those of full karyotyping. Results 16 of 16 trisomy 21, 12 of 12 trisomy 18, two of two trisomy 13, three of four 45, X, one of one XYY and two of two XXY abnormalities were correctly identified. But one false positive case of trisomy 18 and one false negative case of 45, X were observed. The test performed with 100% sensitivity and 99.9% specificity for autosomal aneuploidies and 85.7% sensitivity and 99.9% specificity for sex chromosomal aneuploidies. Compared with three previously reported z-score approaches with/without GC-bias removal and with internal control, the NIFTY test was more accurate and robust for the detection of both autosomal and sex chromosomal aneuploidies in fetuses. Conclusion Our study demonstrates a powerful and reliable methodology for noninvasive prenatal diagnosis.

  12. Role of advanced neuroimaging, fluid biomarkers and genetic testing in the assessment of sport-related concussion: a systematic review.

    Science.gov (United States)

    McCrea, Michael; Meier, Timothy; Huber, Daniel; Ptito, Alain; Bigler, Erin; Debert, Chantel T; Manley, Geoff; Menon, David; Chen, Jen-Kai; Wall, Rachel; Schneider, Kathryn J; McAllister, Thomas

    2017-06-01

    To conduct a systematic review of published literature on advanced neuroimaging, fluid biomarkers and genetic testing in the assessment of sport-related concussion (SRC). Computerised searches of Medline, PubMed, Cumulative Index to Nursing and Allied Health Literature (CINAHL), PsycINFO, Scopus and Cochrane Library from 1 January 2000 to 31 December 2016 were done. There were 3222 articles identified. In addition to medical subject heading terms, a study was included if (1) published in English, (2) represented original research, (3) involved human research, (4) pertained to SRC and (5) involved data from neuroimaging, fluid biomarkers or genetic testing collected within 6 months of injury. Ninety-eight studies qualified for review (76 neuroimaging, 16 biomarkers and 6 genetic testing). Separate reviews were conducted for neuroimaging, biomarkers and genetic testing. A standardised data extraction tool was used to document study design, population, tests employed and key findings. Reviewers used a modified quality assessment of studies of diagnostic accuracy studies (QUADAS-2) tool to rate the risk of bias, and a modified Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system to rate the overall level of evidence for each search. Results from the three respective reviews are compiled in separate tables and an interpretive summary of the findings is provided. Advanced neuroimaging, fluid biomarkers and genetic testing are important research tools, but require further validation to determine their ultimate clinical utility in the evaluation of SRC. Future research efforts should address current gaps that limit clinical translation. Ultimately, research on neurobiological and genetic aspects of SRC is predicted to have major translational significance to evidence-based approaches to clinical management of SRC, much like applied clinical research has had over the past 20 years. © Article author(s) (or their employer(s) unless otherwise

  13. Flight Testing of an Advanced Airborne Natural Gas Leak Detection System

    Energy Technology Data Exchange (ETDEWEB)

    Dawn Lenz; Raymond T. Lines; Darryl Murdock; Jeffrey Owen; Steven Stearns; Michael Stoogenke

    2005-10-01

    ITT Industries Space Systems Division (Space Systems) has developed an airborne natural gas leak detection system designed to detect, image, quantify, and precisely locate leaks from natural gas transmission pipelines. This system is called the Airborne Natural Gas Emission Lidar (ANGEL) system. The ANGEL system uses a highly sensitive differential absorption Lidar technology to remotely detect pipeline leaks. The ANGEL System is operated from a fixed wing aircraft and includes automatic scanning, pointing system, and pilot guidance systems. During a pipeline inspection, the ANGEL system aircraft flies at an elevation of 1000 feet above the ground at speeds of between 100 and 150 mph. Under this contract with DOE/NETL, Space Systems was funded to integrate the ANGEL sensor into a test aircraft and conduct a series of flight tests over a variety of test targets including simulated natural gas pipeline leaks. Following early tests in upstate New York in the summer of 2004, the ANGEL system was deployed to Casper, Wyoming to participate in a set of DOE-sponsored field tests at the Rocky Mountain Oilfield Testing Center (RMOTC). At RMOTC the Space Systems team completed integration of the system and flew an operational system for the first time. The ANGEL system flew 2 missions/day for the duration for the 5-day test. Over the course of the week the ANGEL System detected leaks ranging from 100 to 5,000 scfh.

  14. Advanced testing method to evaluate the performance of respirator filter media.

    Science.gov (United States)

    Wang, Qiang; Golshahi, Laleh; Chen, Da-Ren

    2016-10-02

    Filter media for respirator applications are typically exposed to the cyclic flow condition, which is different from the constant flow condition adopted in filter testing standards. To understand the real performance of respirator filter media in the field it is required to investigate the penetration of particles through respirator filters under cyclic flow conditions representing breathing flow patterns of human beings. This article reports a new testing method for studying the individual effect of breathing frequency (BF) and peak inhalation flow rate (PIFR) on the particle penetration through respirator filter media. The new method includes the use of DMA (Differential Mobility Analyzer)-classified particles having the most penetrating particle size, MPPS (at the constant flowrate of equivalent mean inhalation flow rate, MIFR) as test aerosol. Two condensation particle counters (CPCs) are applied to measure the particle concentrations at the upstream and downstream of test filter media at the same time. Given the 10 Hz sampling time of CPCs, close-to-instantaneous particle penetration could be measured. A pilot study was performed to demonstrate the new testing method. It is found that the effect of BF on the particle penetration of test respirator filter media is of importance at all the tested peak inhalation flow rates (PIFRs), which is different from those reported in the previous work.

  15. Design and Test of Advanced Thermal Simulators for an Alkali Metal-Cooled Reactor Simulator

    Science.gov (United States)

    Garber, Anne E.; Dickens, Ricky E.

    2011-01-01

    The Early Flight Fission Test Facility (EFF-TF) at NASA Marshall Space Flight Center (MSFC) has as one of its primary missions the development and testing of fission reactor simulators for space applications. A key component in these simulated reactors is the thermal simulator, designed to closely mimic the form and function of a nuclear fuel pin using electric heating. Continuing effort has been made to design simple, robust, inexpensive thermal simulators that closely match the steady-state and transient performance of a nuclear fuel pin. A series of these simulators have been designed, developed, fabricated and tested individually and in a number of simulated reactor systems at the EFF-TF. The purpose of the thermal simulators developed under the Fission Surface Power (FSP) task is to ensure that non-nuclear testing can be performed at sufficiently high fidelity to allow a cost-effective qualification and acceptance strategy to be used. Prototype thermal simulator design is founded on the baseline Fission Surface Power reactor design. Recent efforts have been focused on the design, fabrication and test of a prototype thermal simulator appropriate for use in the Technology Demonstration Unit (TDU). While designing the thermal simulators described in this paper, effort were made to improve the axial power profile matching of the thermal simulators. Simultaneously, a search was conducted for graphite materials with higher resistivities than had been employed in the past. The combination of these two efforts resulted in the creation of thermal simulators with power capacities of 2300-3300 W per unit. Six of these elements were installed in a simulated core and tested in the alkali metal-cooled Fission Surface Power Primary Test Circuit (FSP-PTC) at a variety of liquid metal flow rates and temperatures. This paper documents the design of the thermal simulators, test program, and test results.

  16. Point-of-care testing for HCV infection: recent advances and implications for alternative screening.

    Science.gov (United States)

    Parisi, Maria Rita; Soldini, Laura; Vidoni, Gianmarino; Mabellini, Chiara; Belloni, Teresa; Brignolo, Livia; Negri, Silvia; Schlusnus, Karin; Dorigatti, Fernanda; Lazzarin, Adriano

    2014-10-01

    Over the last few years, hepatitis C virus (HCV) infection has emerged as one of the most significant causes of chronic liver disease worldwide, with an estimated prevalence ranging from 2.2 to 3.0%. In Italy, approximately 2% of subjects are infected with HCV. Considering that acute HCV infection is usually asymptomatic, early diagnosis is rare. Those people who develop chronic infection, even though undiagnosed, may suffer serious liver damage, making chronic HCV infection a major health problem. New initiatives are needed to identify a submerged portion of patients with chronic viral hepatitis and to propose controls and antiviral treatments to avoid the progression to liver cirrhosis or hepatocellular carcinoma (HCC). Since January 2011, the Infectious Diseases Department of San Raffaele Scientific Institute in Milan has been carrying out a prevention program called "EASY test project", using a new oral test, the OraQuick® HCV rapid antibody test (OraSure technologies, Inc.). The main objective of the project is to evaluate the acceptability of an alternative, free and anonymous HCV test offer, available in different settings (Points of Care, STDs Prevention clinics and General Practitioner clinics). From January 2011 to April 2014, 29,600 subjects were approached to inform them about HCV infection and other sexually transmitted diseases; 4,507 (15.2% of the contacted subjects) of them, total eligible volunteers, performed HCV tests on saliva and completed the interview in the alternative POCTs. Twenty-seven subjects (0.6% of the total) turned HCV oral test reactive (27/4.507) during the evaluation period; all of them were confirmed by conventional test. All 27 patients were asymptomatic and without a history of HCV-re- lated symptoms. The results from this analysis suggest that the promotion of alternative HCV test screening has not yet been fully developed as a strategy to increase levels of HCV testing among people at risk for HCV infection. Increasing

  17. Advanced Failure Determination Measurement Techniques Used in Thermal Fatigue Life Testing of Electronic Packaging

    Science.gov (United States)

    Wallace, A. P.; Cornford, S. L.; Gross, M. A.

    1996-01-01

    Thermal fatigue life testing of various electronic packaging technologies is being performed by the Reliability Technology Group at the Jet Propulsion Laboratory. These testing efforts are in progress to improve uderstanding of the reliability issues associated with low volume packaging technologies for space applications and to develop qualification and acceptance approaches for these technologies. The work described here outlines the electrical failure detection techniques used during testing by documenting the circuits and components used to make these measurements, the sensitivity of the measurements, and the applicability of each specific measurement.

  18. Project Description Advanced Fuel Cycle Initiative AFC-2A and AFC-2B Experiments

    Energy Technology Data Exchange (ETDEWEB)

    AFCI AFC-2A and AFC-2B Experiments Project Executi

    2007-03-01

    The proposed AFC-2A and AFC-2B irradiation experiments are a continuation of the AFC-1 fuel test series currently in progress in the ATR. This document discusses the experiments and the planned activities that will take place.

  19. LIGHT WATER REACTOR ACCIDENT TOLERANT FUELS IRRADIATION TESTING

    Energy Technology Data Exchange (ETDEWEB)

    Carmack, William Jonathan [Idaho National Laboratory; Barrett, Kristine Eloise [Idaho National Laboratory; Chichester, Heather Jean MacLean [Idaho National Laboratory

    2015-09-01

    The purpose of Accident Tolerant Fuels (ATF) experiments is to test novel fuel and cladding concepts designed to replace the current zirconium alloy uranium dioxide (UO2) fuel system. The objective of this Research and Development (R&D) is to develop novel ATF concepts that will be able to withstand loss of active cooling in the reactor core for a considerably longer time period than the current fuel system while maintaining or improving the fuel performance during normal operations, operational transients, design basis, and beyond design basis events. It was necessary to design, analyze, and fabricate drop-in capsules to meet the requirements for testing under prototypic LWR temperatures in Idaho National Laboratory's Advanced Test Reactor (ATR). Three industry led teams and one DOE team from Oak Ridge National Laboratory provided fuel rodlet samples for their new concepts for ATR insertion in 2015. As-built projected temperature calculations were performed on the ATF capsules using the BISON fuel performance code. BISON is an application of INL’s Multi-physics Object Oriented Simulation Environment (MOOSE), which is a massively parallel finite element based framework used to solve systems of fully coupled nonlinear partial differential equations. Both 2D and 3D models were set up to examine cladding and fuel performance.

  20. SMART-DS: Synthetic Models for Advanced, Realistic Testing: Distribution Systems and Scenarios

    Energy Technology Data Exchange (ETDEWEB)

    Hodge, Bri-Mathias; Palmintier, Bryan

    2016-03-03

    This presentation provides an overview of full-scale, high-quality, synthetic distribution system data set(s) for testing distribution automation algorithms, distributed control approaches, ADMS capabilities, and other emerging distribution technologies.