WorldWideScience

Sample records for atomic clocks

  1. Optical atomic clocks

    Science.gov (United States)

    Poli, N.; Oates, C. W.; Gill, P.; Tino, G. M.

    2013-12-01

    In the last ten years extraordinary results in time and frequency metrology have been demonstrated. Frequency-stabilization techniques for continuous-wave lasers and femtosecond optical frequency combs have enabled a rapid development of frequency standards based on optical transitions in ultra-cold neutral atoms and trapped ions. As a result, today's best performing atomic clocks tick at an optical rate and allow scientists to perform high-resolution measurements with a precision approaching a few parts in 1018. This paper reviews the history and the state of the art in optical-clock research and addresses the implementation of optical clocks in a possible future redefinition of the SI second as well as in tests of fundamental physics.

  2. Optical atomic clocks

    CERN Document Server

    Poli, N; Gill, P; Tino, G M

    2014-01-01

    In the last ten years extraordinary results in time and frequency metrology have been demonstrated. Frequency-stabilization techniques for continuous-wave lasers and femto-second optical frequency combs have enabled a rapid development of frequency standards based on optical transitions in ultra-cold neutral atoms and trapped ions. As a result, today's best performing atomic clocks tick at an optical rate and allow scientists to perform high-resolution measurements with a precision approaching a few parts in $10^{18}$. This paper reviews the history and the state of the art in optical-clock research and addresses the implementation of optical clocks in a possible future redefinition of the SI second as well as in tests of fundamental physics.

  3. Optical atomic clocks and metrology

    Science.gov (United States)

    Ludlow, Andrew

    2014-05-01

    The atomic clock has long demonstrated the capability to measure time or frequency with very high precision. Consequently, these clocks are used extensively in technological applications such as advanced synchronization or communication and navigation networks. Optical atomic clocks are next- generation timekeepers which reference narrowband optical transitions between suitable atomic states. Many optical time/frequency standards utilize state-of-the-art quantum control and precision measurement. Combined with the ultrahigh quality factors of the atomic resonances at their heart, optical atomic clocks have promised new levels of timekeeping precision, orders of magnitude higher than conventional atomic clocks based on microwave transitions. Such measurement capability enables and/or enhances many of the most exciting applications of these clocks, including the study of fundamental laws of physics through the measurement of time evolution. Here, I will highlight optical atomic clocks and their utility, as well as review recent advances in their development and performance. In particular, I will describe in detail the optical lattice clock and the realization of frequency measurement at the level of one part in 1018. To push the performance of these atomic timekeepers to such a level and beyond, several key advances are being explored worldwide. These will be discussed generally, with particular emphasis on our recent efforts at NIST in developing the optical lattice clock based on atomic ytterbium.

  4. Microchip-Based Trapped-Atom Clocks

    CERN Document Server

    Vuletic, Vladan; Schleier-Smith, Monika H

    2011-01-01

    This is a chapter of a recently published book entitled Atom Chips, edited by Jakob Reichel and Vladan Vuletic. The contents of this chapter include: Basic Principles; Atomic-Fountain versus Trapped-Atom Clocks; Optical-Transition Clocks versus Microwave Clocks; Clocks with Magnetically Trapped Atoms--Fundamental Limits and Experimental Demonstrations; Readout in Trapped-Atom Clocks; and Spin Squeezing.

  5. Cold atom Clocks and Applications

    CERN Document Server

    Bize, S; Abgrall, M; Marion, H; Maksimovic, I; Cacciapuoti, L; Gruenert, J; Vian, C; Dos Santos, F P; Rosenbusch, P; Lemonde, P; Santarelli, G; Wolf, P; Clairon, A; Luiten, A; Tobar, M; Salomon, C

    2005-01-01

    This paper describes advances in microwave frequency standards using laser-cooled atoms at BNM-SYRTE. First, recent improvements of the $^{133}$Cs and $^{87}$Rb atomic fountains are described. Thanks to the routine use of a cryogenic sapphire oscillator as an ultra-stable local frequency reference, a fountain frequency instability of $1.6\\times 10^{-14}\\tau^{-1/2}$ where $\\tau $ is the measurement time in seconds is measured. The second advance is a powerful method to control the frequency shift due to cold collisions. These two advances lead to a frequency stability of $2\\times 10^{-16}$ at $50,000s for the first time for primary standards. In addition, these clocks realize the SI second with an accuracy of $7\\times 10^{-16}$, one order of magnitude below that of uncooled devices. In a second part, we describe tests of possible variations of fundamental constants using $^{87}$Rb and $^{133}$Cs fountains. Finally we give an update on the cold atom space clock PHARAO developed in collaboration with CNES. This ...

  6. Could Atomic clocks be affected by neutrinos?

    CERN Document Server

    Hanafi, Hanaa

    2016-01-01

    An atomic clock is a clock device that uses an electronic transition frequency of the electromagnetic spectrum of atoms as a frequency standard in order to derive a time standard since time is the reciprocal of frequency. If the electronic transition frequencies are in an "optical region", we are talking in this case about optical atomic clocks. If they are in an "microwave region" these atomic clocks are made of the metallic element cesium so they are called Cesium atomic clocks. Atomic clocks are the most accurate time and frequency standards known despite the different perturbations that can affect them, a lot of researches were made in this domain to show how the transitions can be different for different type of perturbations..Since atomic clocks are very sensitive devices, based on coherent states (A coherent state tends to loose coherence after interacting). One question can arise (from a lot of questions) which is why cosmic neutrinos are not affecting these clocks? The answer to this question requir...

  7. Using Atomic Clocks to Detect Gravitational Waves

    CERN Document Server

    Loeb, Abraham

    2015-01-01

    Atomic clocks have recently reached a fractional timing precision of $<10^{-18}$. We point out that an array of atomic clocks, distributed along the Earth's orbit around the Sun, will have the sensitivity needed to detect the time dilation effect of mHz gravitational waves (GWs), such as those emitted by supermassive black hole binaries at cosmological distances. Simultaneous measurement of clock-rates at different phases of a passing GW provides an attractive alternative to the interferometric detection of temporal variations in distance between test masses separated by less than a GW wavelength, currently envisioned for the eLISA mission.

  8. Optical lattice clock with Strontium atoms

    International Nuclear Information System (INIS)

    This thesis presents the latest achievements regarding the optical lattice clock with Strontium atoms developed at LNE-SYRTE. After a review of the different types of optical clocks that are currently under development, we stress on the concept of optical lattice clock which was first imagined for Sr87 using the 1S0 → 3P0 transition. We exhibit the features of this atom, in particular the concept of magic wavelength for the trap, and the achievable performances for this kind of clock. The second part presents the experimental aspects, insisting particularly on the ultra-stable laser used for the interrogation of the atoms which is a central part of the experiment. Among the latest improvements, an optical pumping phase and an interrogation phase using a magnetic field have been added in order to refine the evaluation of the Zeeman effect. Finally, the last part presents the experimental results. The last evaluation of the clock using Sr87 atoms allowed us to reach a frequency accuracy of 2.6*10-15 and a measurement in agreement with the one made at JILA (Tokyo university) at the 10-15 level. On another hand, thanks to recent theoretical proposals, we made a measurement using the bosonic isotope Sr88 by adapting the experimental setup. This measurement represents the first evaluation for this type of clock, with a frequency accuracy of 7*10-14. (author)

  9. Sagnac interferometry with a single atomic clock

    CERN Document Server

    Stevenson, R; Bishop, T; Lesanovsky, I; Fernholz, T

    2015-01-01

    We theoretically discuss an implementation of a Sagnac interferometer with cold atoms. In contrast to currently existing schemes our protocol does not rely on any free propagation of atoms. Instead it is based on superpositions of fully confined atoms and state-dependent transport along a closed path. Using Ramsey sequences for an atomic clock, the accumulated Sagnac phase is encoded in the resulting population imbalance between two internal (clock) states. Using minimal models for the above protocol we analytically quantify limitations arising from atomic dynamics and finite temperature. We discuss an actual implementation of the interferometer with adiabatic radio-frequency potentials that is inherently robust against common mode noise as well as phase noise from the reference oscillator.

  10. Mapping Out Atom-Wall Interaction with Atomic Clocks

    International Nuclear Information System (INIS)

    We explore the feasibility of probing atom-wall interaction with atomic clocks based on atoms trapped in engineered optical lattices. Optical lattice is normal to the wall. By monitoring the wall-induced clock shift at individual wells of the lattice, one would measure the dependence of the atom-wall interaction on the atom-wall separation. We find that the induced clock shifts are large and observable at already experimentally demonstrated levels of accuracy. We show that this scheme may uniquely probe the long-range atom-wall interaction in all three qualitatively distinct regimes of the interaction: van der Waals (image-charge interaction), Casimir-Polder (QED vacuum fluctuations), and Lifshitz (thermal-bath fluctuations) regimes.

  11. The Deep Space Atomic Clock Mission

    Science.gov (United States)

    Ely, Todd A.; Koch, Timothy; Kuang, Da; Lee, Karen; Murphy, David; Prestage, John; Tjoelker, Robert; Seubert, Jill

    2012-01-01

    The Deep Space Atomic Clock (DSAC) mission will demonstrate the space flight performance of a small, low-mass, high-stability mercury-ion atomic clock with long term stability and accuracy on par with that of the Deep Space Network. The timing stability introduced by DSAC allows for a 1-Way radiometric tracking paradigm for deep space navigation, with benefits including increased tracking via utilization of the DSN's Multiple Spacecraft Per Aperture (MSPA) capability and full ground station-spacecraft view periods, more accurate radio occultation signals, decreased single-frequency measurement noise, and the possibility for fully autonomous on-board navigation. Specific examples of navigation and radio science benefits to deep space missions are highlighted through simulations of Mars orbiter and Europa flyby missions. Additionally, this paper provides an overview of the mercury-ion trap technology behind DSAC, details of and options for the upcoming 2015/2016 space demonstration, and expected on-orbit clock performance.

  12. Satellite virtual atomic clock with pseudorange difference function

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    Satellite atomic clocks are the basis of GPS for the control of time and frequency of navigation signals. In the Chinese Area Positioning System (CAPS), a satellite navigation system without the satellite atomic clocks onboard is successfully developed. Thus, the method of time synchronization based on satellite atomic clocks in GPS is not suitable. Satellite virtual atomic clocks are used to implement satellite navigation. With the satellite virtual atomic clocks, the time at which the signals are transmitted from the ground can be delayed into the time that the signals are transmitted from the satellites and the pseudorange measuring can be fulfilled as in GPS. Satellite virtual atomic clocks can implement the navigation, make a pseudorange difference, remove the ephemeris error, and improve the accuracy of navigation positioning. They not only provide a navigation system without satellite clocks, but also a navigation system with pseudorange difference.

  13. Next Generation JPL Ultra-Stable Trapped Ion Atomic Clocks

    Science.gov (United States)

    Burt, Eric; Tucker, Blake; Larsen, Kameron; Hamell, Robert; Tjoelker, Robert

    2013-01-01

    Over the past decade, trapped ion atomic clock development at the Jet Propulsion Laboratory (JPL) has focused on two directions: 1) new atomic clock technology for space flight applications that require strict adherence to size, weight, and power requirements, and 2) ultra-stable atomic clocks, usually for terrestrial applications emphasizing ultimate performance. In this paper we present a new ultra-stable trapped ion clock designed, built, and tested in the second category. The first new standard, L10, will be delivered to the Naval Research Laboratory for use in characterizing DoD space clocks.

  14. Atomic fountains and optical clocks at SYRTE: status and perspectives

    CERN Document Server

    Abgrall, M; De Sarlo, L; Guéna, J; Laurent, Ph; Coq, Y Le; Targat, R Le; Lodewyck, J; Lours, M; Rosenbusch, P; Rovera, D; Bize, S

    2015-01-01

    In this article, we report on the work done with the LNE-SYRTE atomic clock ensemble during the last 10 years. We cover progress made in atomic fountains and in their application to timekeeping. We also cover the development of optical lattice clocks based on strontium and on mercury. We report on tests of fundamental physical laws made with these highly accurate atomic clocks. We also report on work relevant to a future possible redefinition of the SI second.

  15. Atomic clocks based on adaptive phase measurements with entangled atoms

    Science.gov (United States)

    Andre, Axel; Sorensen, Anders; Lukin, Mikhail

    2005-05-01

    We show that the frequency stability of atomic clocks limited by local oscillator frequency fluctuations [1] can be greatly improved by using an adaptive measurement strategy with entangled atoms. Our method uses multiple atomic sub-ensembles with various degrees of spin-squeezing and sequential adaptive measurements of the Ramsey phase. With properly optimized degree of squeezing, this method reaches the Heisenberg limit for phase measurements δφ˜1/N, where N is the number of atoms. In addition, we show that multiple interrogation times for these sub-ensembles can be used to improve the long-term stability of the clock. This method allows one to use a very long interrogation time, limited only by environmental fluctuations. The combination of the above two methods leads to an ultimate long-term frequency stability of the clock scaling as σy(τ)=A. Andr'e, A. S. Sørensen, and M. D. Lukin, Phys. Rev. Lett. 92, 230801 (2004).

  16. The quantum beat principles and applications of atomic clocks

    CERN Document Server

    Major, F

    2007-01-01

    This work attempts to convey a broad understanding of the physical principles underlying the workings of these quantum-based atomic clocks, with introductory chapters placing them in context with the early development of mechanical clocks and the introduction of electronic time-keeping as embodied in the quartz-controlled clocks. While the book makes no pretense at being a history of atomic clocks, it nevertheless takes a historical perspective in its treatment of the subject. Intended for nonspecialists with some knowledge of physics or engineering, The Quantum Beat covers a wide range of salient topics relevant to atomic clocks, treated in a broad intuitive manner with a minimum of mathematical formalism. Detailed descriptions are given of the design principles of the rubidium, cesium, hydrogen maser, and mercury ion standards; the revolutionary changes that the advent of the laser has made possible, such as laser cooling, optical pumping, the formation of "optical molasses," and the cesium "fountain" stand...

  17. Atomic clocks: new prospects in metrology and geodesy

    CERN Document Server

    Delva, Pacôme

    2013-01-01

    We present the latest developments in the field of atomic clocks and their applications in metrology and fundamental physics. In the light of recent advents in the accuracy of optical clocks, we present an introduction to the relativistic modelization of frequency transfer and a detailed review of chronometric geodesy.

  18. Design and Construction of an Atomic Clock on an Atom Chip

    International Nuclear Information System (INIS)

    We describe the design and construction of an atomic clock on an atom chip, intended as a secondary standard, with a stability in the range of few 10-13 at 1 s. This clock is based on a two-photon transition between the hyperfine states |F = 1; mF = -1> and |2; 1> of the electronic ground state of the 87Rb atom. This transition is interrogated using a Ramsey scheme, operating on either a cloud of thermal atoms or a Bose-Einstein condensate. In contrast to atomic fountain clocks, this clock is magnetically trapped on an atom chip. We describe a theoretical model of the clock stability and the design and construction of a dedicated apparatus. It is able to control the magnetic field at the relative 10-5 level and features a hybrid atom chip, containing DC conductors as well as a microwave transmission line for the clock interrogation. (author)

  19. An atomic clock with $10^{-18}$ instability

    CERN Document Server

    Hinkley, N; Phillips, N B; Schioppo, M; Lemke, N D; Beloy, K; Pizzocaro, M; Oates, C W; Ludlow, A D

    2013-01-01

    Atomic clocks have been transformational in science and technology, leading to innovations such as global positioning, advanced communications, and tests of fundamental constant variation. Next-generation optical atomic clocks can extend the capability of these timekeepers, where researchers have long aspired toward measurement precision at 1 part in $\\bm{10^{18}}$. This milestone will enable a second revolution of new timing applications such as relativistic geodesy, enhanced Earth- and space-based navigation and telescopy, and new tests on physics beyond the Standard Model. Here, we describe the development and operation of two optical lattice clocks, both utilizing spin-polarized, ultracold atomic ytterbium. A measurement comparing these systems demonstrates an unprecedented atomic clock instability of $\\bm{1.6\\times 10^{-18}}$ after only $\\bm{7}$ hours of averaging.

  20. Geophysical applicability of atomic clocks: direct continental geoid mapping

    CERN Document Server

    Bondarescu, Ruxandra; Hetényi, György; Boschi, Lapo; Jetzer, Philippe; Balakrishna, Jayashree; 10.1111/j.1365-246X.2012.05636.x

    2012-01-01

    The geoid is the true physical figure of the Earth, a particular equipotential surface of the gravity field of the Earth that accounts for the effect of all subsurface density variations. Its shape approximates best (in the sense of least squares) the mean level of oceans, but the geoid is more difficult to determine over continents. Satellite missions carry out distance measurements and derive the gravity field to provide geoid maps over the entire globe. However, they require calibration and extensive computations including integration, which is a non-unique operation. Here we propose a direct method and a new tool that directly measures geopotential differences on continents using atomic clocks. General Relativity Theory predicts constant clock rate at sea level, and faster (resp. slower) clock rate above (resp. below) sea level. The technology of atomic clocks is on the doorstep of reaching an accuracy level in clock rate that is equivalent to 1 cm in determining equipotential surface (including geoid) he...

  1. An Analysis of the Stationary Operation of Atomic Clocks

    Science.gov (United States)

    Fraas, Martin

    2016-09-01

    We develop an abstract model of atomic clocks that fully describes the dynamics of repeated synchronization between a classical oscillator and a quantum reference. We prove existence of a stationary state of the model and study its dependence on the control scheme, the interrogation time and the stability of the oscillator. For unbiased atomic clocks, we derive a fundamental bound on atomic clocks long time stability for a given local oscillator noise. In particular, we show that for a local oscillator noise with integrated frequency variance scaling as {T^α} for short times T, the optimal clock time variance scales as {F^{-(α +1)/(α +2)}} with respect to the quantum Fisher information, F, associated to the quantum reference. In an attempt to prove the bounds without the unbiasedness assumption, we derive a new Cramer-Rao type inequality.

  2. Atomic Clocks and Variations of the FIne Structure Constant

    Science.gov (United States)

    Prestage, John D.; Tjoelker, Robert L.; Maleki, Lute

    1995-01-01

    We describe a new test for possible variations of the fine structure constant alpha by comparisons of rates between clocks based on hyperfine transitions in alkali atoms with different atomic number Z. H-maser, Cs, and Hg(+) clocks have a different dependence on alpha via relativistic contributions of order (Z-alpha)(sup 2). Recent H-maser vs Hg(+) clock comparison data improve laboratory limits on a time variation by 100-fold to give dot-alpha less than or equal to 3.7 x 10(exp -14)/yr. Future laser cooled clocks (Be(+), Rb, Cs, Hg(+), etc.), when compared, will yield the most sensitive of all tests for dot-alpha/alpha.

  3. A Movable-Cavity Cold Atom Space Clock

    Institute of Scientific and Technical Information of China (English)

    BIAN Feng-Gang; WEI Rong; JIANG Hai-Feng; WANG Yu-Zhu

    2005-01-01

    @@ We present an experimental scheme of a cold atom space clock with a movable cavity. By using a single microwave cavity, we find that the clock has a significant advantage, i.e. the longitudinal cavity phase shift is eliminated. A theoretical analysis has been carried out in terms of the relation between the atomic transition probability and the velocity of the moving cavity by taking into account the velocity distribution of cold atoms. The requirements for the microwave power and its stability for atomic πr /2 excitation at different moving velocities of the cavity lead to the determination of the proper working parameters of the rubidium clock in frequency accuracy 10-17. Finally,the mechanical stability for the scheme is analysed and the ways of solving the possible mechanical instability of the device are proposed.

  4. Gravitational wave detection with optical lattice atomic clocks

    OpenAIRE

    Kolkowitz, Shimon; Pikovski, Igor; Langellier, Nicholas; Lukin, Mikhail D.; Walsworth, Ronald L.; Ye, Jun

    2016-01-01

    We propose a space-based gravitational wave detector consisting of two spatially separated, drag-free satellites sharing ultra-stable optical laser light over a single baseline. Each satellite contains an optical lattice atomic clock, which serves as a sensitive, narrowband detector of the local frequency of the shared laser light. A synchronized two-clock comparison between the satellites will be sensitive to the effective Doppler shifts induced by incident gravitational waves (GWs) at a lev...

  5. Tests of local position invariance using continuously running atomic clocks

    CERN Document Server

    Peil, Steven; Hanssen, James L; Swanson, Thomas B; Ekstrom, Christopher R; 10.1103/PhysRevA.87.010102

    2013-01-01

    Tests of local position invariance (LPI) made by comparing the relative redshift of atomic clocks based on different atoms have been carried out for a variety of pairs of atomic species. In most cases, several absolute frequency measurements per year are used to look for an annual signal, resulting in tests that can span on order of a decade. By using the output of continuously running clocks, we carry out LPI tests with comparable or higher precision after less than 1.5 years. These include new measurements of the difference in redshift anomalies \\beta\\ for hyperfine transitions in Rb87 and Cs133 and in H and Cs133 and a measurement comparing Rb87 and H, resulting in a stringent limit on LPI, \\beta(Rb) - \\beta(H)=(-2.7 +/- 4.9) x 10^(-7). The method of making these measurements for continuous clocks is discussed.

  6. 0.75 atoms improve the clock signal of 10,000 atoms

    DEFF Research Database (Denmark)

    Kruse, I.; Lange, K; Peise, Jan;

    2016-01-01

    , the vacuum noise restricts the precision of the interferometer to the standard quantum limit (SQL). Here, we propose and experimentally demonstrate a novel clock configuration that surpasses the SQL by squeezing the vacuum in the empty input state. We create a squeezed vacuum state containing an average of 0.......75 atoms to improve the clock sensitivity of 10,000 atoms by 2.05 dB. The SQL poses a significant limitation for today's microwave fountain clocks, which serve as the main time reference. We evaluate the major technical limitations and challenges for devising a next generation of fountain clocks based...

  7. Quantum Network of Atom Clocks: A Possible Implementation with Neutral Atoms

    Science.gov (United States)

    Kómár, P.; Topcu, T.; Kessler, E. M.; Derevianko, A.; Vuletić, V.; Ye, J.; Lukin, M. D.

    2016-08-01

    We propose a protocol for creating a fully entangled Greenberger-Horne-Zeilinger-type state of neutral atoms in spatially separated optical atomic clocks. In our scheme, local operations make use of the strong dipole-dipole interaction between Rydberg excitations, which give rise to fast and reliable quantum operations involving all atoms in the ensemble. The necessary entanglement between distant ensembles is mediated by single-photon quantum channels and collectively enhanced light-matter couplings. These techniques can be used to create the recently proposed quantum clock network based on neutral atom optical clocks. We specifically analyze a possible realization of this scheme using neutral Yb ensembles.

  8. Searching for dark matter with optical atomic clocks

    CERN Document Server

    Wcislo, Piotr; Bober, Marcin; Cygan, Agata; Lisak, Daniel; Ciurylo, Roman; Zawada, Michal

    2016-01-01

    One of the most fundamental questions of modern physics is the existence of yet unknown forms of matter and interactions. The total mass density of the Universe appears to be dominated by some hypothetical dark matter (DM). However, beyond its gravitational interaction at galactic scale, little is known about the DM nature and properties. One possibility is that it has a form of stable topological defects built from light scalar fields which, for nonzero DM-SM coupling, would result in transient variations of fundamental constants. Optical atomic clocks, highly sensitive to variations of the fine-structure constant, seem to be natural candidates for such searches. Here we demonstrate the first experimental constraint on the strength of transient DM-SM coupling determined with optical atomic clocks. Instead of measuring the phase difference between two distant clocks we determine a common component of their readouts. We show that our constraint, even for one-day measurement, greatly exceeds previous laboratory...

  9. Conceptual Design of a Micron-Scale Atomic Clock

    CERN Document Server

    Hannah, Eric C

    2007-01-01

    A theoretical proposal for reducing an entire atomic clock to micron dimensions. A phosphorus or nitrogen atom is introduced into a fullerene cage. This endohedral fullerene is then coated with an insulating shell and a number of them are deposited as a thin layer on a silicon chip. Next to this layer a GMR sensor is fabricated which is close to the endohedral fullerenes. This GMR sensor measures oscillating magnetic fields on the order of micro-gauss from the nuclear spins varying at the frequency of the hyperfine transition (413 MHz frequency). Given the micron scale and simplicity of this system only a few transistors are needed to control the waveforms and to perform digital clocking. This new form of atomic clock exhibits extremely low power (nano watts), high vibration and shock resistance, stability on the order of 10^{-9}, and is compatible with MEMS fabrication and chip integration. As GMR sensors continue to improve in sensitivity the stability of this form of atomic clock will increase proportionat...

  10. Atomic clocks as a tool to monitor vertical surface motion

    CERN Document Server

    Bondarescu, Ruxandra; Lundgren, Andrew; Hetényi, György; Houlié, Nicolas; Jetzer, Philippe; Bondarescu, Mihai

    2015-01-01

    Atomic clock technology is advancing rapidly, now reaching stabilities of $\\Delta f/f \\sim 10^{-18}$, which corresponds to resolving $1$ cm in equivalent geoid height over an integration timescale of about 7 hours. At this level of performance, ground-based atomic clock networks emerge as a tool for monitoring a variety of geophysical processes by directly measuring changes in the gravitational potential. Vertical changes of the clock's position due to magmatic, volcanic, post-seismic or tidal deformations can result in measurable variations in the clock tick rate. As an example, we discuss the geopotential change arising due to an inflating point source (Mogi model), and apply it to the Etna volcano. Its effect on an observer on the Earth's surface can be divided into two different terms: one purely due to uplift and one due to the redistribution of matter. Thus, with the centimetre-level precision of current clocks it is already possible to monitor volcanoes. The matter redistribution term is estimated to b...

  11. 2e-18 total uncertainty in an atomic clock

    CERN Document Server

    Nicholson, T L; Hutson, R B; Marti, G E; Bloom, B J; McNally, R L; Zhang, W; Barrett, M D; Safronova, M S; Strouse, G F; Tew, W L; Ye, J

    2014-01-01

    The pursuit of better atomic clocks has advanced many research areas, providing better quantum state control, new insights in quantum science, tighter limits on fundamental constant variation, and improved tests of relativity. The record for the best stability and accuracy is currently held by optical lattice clocks. This work takes an important step towards realizing the full potential of a many-particle clock with a state-of-the-art stable laser. Here, we achieve fractional stability of 2.2e-16 at 1 s by using seconds-long coherent interrogations of our clock transition in a low-density system not limited by atomic interactions. With this better stability, we perform a new accuracy evaluation of our clock, improving many systematic uncertainties that limited our previous measurements, such as the lattice ac Stark and blackbody radiation (BBR) shifts. For the lattice ac Stark systematic, we identify the lattice laser frequency where the scalar and tensor components of the shift cancel, allowing for state ind...

  12. The fission time scale measured with an atomic clock

    NARCIS (Netherlands)

    Kravchuk, VL; Wilschut, HW; Hunyadi, M; Kopecky, S; Lohner, H; Rogachevskiy, A; Siemssen, RH; Krasznahorkay, A; Hamilton, JH; Ramayya, AV; Carter, HK

    2003-01-01

    We present a new direct method of measuring the fission absolute time scale using an atomic clock based on the lifetime of a vacancy in the atomic K-shell. We studied the reaction Ne-20 + Th-232 -> O-16 + U-236* at 30 MeV/u. The excitation energy of about 115 MeV in such a reaction is in the range w

  13. Atomic Clock Ensemble in Space: Scientific Objectives and Mission Status

    Energy Technology Data Exchange (ETDEWEB)

    Cacciapuoti, L. [European Space Agency, ESTEC, Keplerlaan 1 - P.O. Box 299, 2200 AG Noordwijk ZH (Netherlands)], E-mail: Luigi.Cacciapuoti@esa.int; Dimarcq, N.; Santarelli, G.; Laurent, P.; Lemonde, P.; Clairon, A. [SYRTE-CNRS UMR8630, Observatoire de Paris, 61, avenue de l' Observatoire 75014 Paris (France); Berthoud, P.; Jornod, A. [Observatoire de Neuchatel, 58, rue de l' Observatoire, CH-2000 Neuchatel (Switzerland); Reina, F.; Feltham, S. [European Space Agency, ESTEC, Keplerlaan 1 - P.O. Box 299, 2200 AG Noordwijk ZH (Netherlands); Salomon, C. [Laboratoire Kastler Brossel, ENS, 24, rue Lhomond, 75005 Paris (France)

    2007-04-15

    Atomic Clock Ensemble in Space (ACES) is a mission in fundamental physics that will operate a new generation of atomic clocks in the microgravity environment of the International Space Station. Fractional frequency instability and inaccuracy at the 10{sup -16} level will be achieved. The on-board time base, distributed on Earth via a microwave link, will be used for space-to-ground as well as ground-to-ground comparisons of atomic frequency standards. Based on these comparisons, ACES will perform fundamental physics tests and develop applications in time and frequency metrology, universal time scales, global positioning and navigation, geodesy, and gravimetry. After a general overview of the mission concept and its scientific objectives, the present status of ACES instruments and sub-systems will be discussed.

  14. Searching for Dark Matter with Atomic Clocks and Laser Interferometry

    Science.gov (United States)

    Stadnik, Yevgeny; Flambaum, Victor

    2016-05-01

    We propose new schemes for the direct detection of low-mass bosonic dark matter, which forms a coherently oscillating classical field and resides in the observed galactic dark matter haloes, using atomic clock, atomic spectroscopy and laser interferometry measurements in the laboratory. We have recently shown that such dark matter can produce both a `slow' cosmological evolution and oscillating variations in the fundamental constants. Using recent atomic dysprosium spectroscopy measurements in, we have derived limits on the quadratic interactions of scalar dark matter with ordinary matter that improve on existing constraints by up to 15 orders of magnitude. We have also proposed the use of laser and maser interferometry as novel high-precision platforms to search for dark matter, with effects due to the variation of the electromagnetic fine-structure constant on alterations in the accumulated phase enhanced by up to 14 orders of magnitude. Other possibilities include the use of highly-charged ions, molecules and nuclear clocks.

  15. Synchronization of Active Atomic Clocks via Quantum and Classical Channels

    CERN Document Server

    Roth, Alexander

    2016-01-01

    Superradiant lasers based on atomic ensembles exhibiting ultra-narrow optical transitions can emit light of unprecedented spectral purity and may serve as active atomic clocks. We consider two frequency-detuned active atomic clocks, which are coupled in a cascaded setup, i.e. as master & slave lasers, and study the synchronization of the slave to the master clock. In a setup where both atomic ensembles are coupled to a common cavity mode such synchronization phenomena have been predicted by Xu et al. [Phys. Rev. Lett. 113, 154101 (2014)] and experimentally observed by Weiner et al. [arXiv:1503.06464 (2015)]. Here we demonstrate that synchronization still occurs in cascaded setups but exhibits distinctly different phase diagrams. We study the characteristics of synchronization in comparison to the case of coupling through a common cavity. We also consider synchronization through a classical channel where light of the master laser is measured phase sensitively and the slave laser is injection locked by feed...

  16. Gravitational wave detection with optical lattice atomic clocks

    CERN Document Server

    Kolkowitz, Shimon; Langellier, Nicholas; Lukin, Mikhail D; Walsworth, Ronald L; Ye, Jun

    2016-01-01

    We propose a space-based gravitational wave detector consisting of two spatially separated, drag-free satellites sharing ultra-stable optical laser light over a single baseline. Each satellite contains an optical lattice atomic clock, which serves as a sensitive, narrowband detector of the local frequency of the shared laser light. A synchronized two-clock comparison between the satellites will be sensitive to the effective Doppler shifts induced by incident gravitational waves (GWs) at a level competitive with other proposed space-based GW detectors, while providing complementary features. The detected signal is a differential frequency shift of the shared laser light due to the relative velocity of the satellites, rather than a phase shift arising from the relative satellite positions, and the detection window can be tuned through the control sequence applied to the atoms' internal states. This scheme enables the detection of GWs from continuous, spectrally narrow sources, such as compact binary inspirals, ...

  17. Optical lattice clock with Strontium atoms; Horloge a reseau optique a atomes de strontium

    Energy Technology Data Exchange (ETDEWEB)

    Baillard, X

    2008-01-15

    This thesis presents the latest achievements regarding the optical lattice clock with Strontium atoms developed at LNE-SYRTE. After a review of the different types of optical clocks that are currently under development, we stress on the concept of optical lattice clock which was first imagined for Sr{sup 87} using the {sup 1}S{sub 0} {yields} {sup 3}P{sub 0} transition. We exhibit the features of this atom, in particular the concept of magic wavelength for the trap, and the achievable performances for this kind of clock. The second part presents the experimental aspects, insisting particularly on the ultra-stable laser used for the interrogation of the atoms which is a central part of the experiment. Among the latest improvements, an optical pumping phase and an interrogation phase using a magnetic field have been added in order to refine the evaluation of the Zeeman effect. Finally, the last part presents the experimental results. The last evaluation of the clock using Sr{sup 87} atoms allowed us to reach a frequency accuracy of 2.6*10{sup -15} and a measurement in agreement with the one made at JILA (Tokyo university) at the 10{sup -15} level. On another hand, thanks to recent theoretical proposals, we made a measurement using the bosonic isotope Sr{sup 88} by adapting the experimental setup. This measurement represents the first evaluation for this type of clock, with a frequency accuracy of 7*10{sup -14}. (author)

  18. Generating and probing entangled states for optical atomic clocks

    Science.gov (United States)

    Braverman, Boris; Kawasaki, Akio; Vuletic, Vladan

    2016-05-01

    The precision of quantum measurements is inherently limited by projection noise caused by the measurement process itself. Spin squeezing and more complex forms of entanglement have been proposed as ways of surpassing this limitation. In our system, a high-finesse asymmetric micromirror-based optical cavity can mediate the atom-atom interaction necessary for generating entanglement in an 171 Yb optical lattice clock. I will discuss approaches for creating, characterizing, and optimally utilizing these nonclassical states for precision measurement, as well as recent progress toward their realization. This research is supported by DARPA QuASAR, NSF, and NSERC.

  19. Development of a compact cold-atom atomic clock based on coherent population trapping

    Science.gov (United States)

    Blanshan, Eric M.

    Field-grade atomic clocks capable of primary standard performance in compact physics packages would be of significant value in a variety of applications ranging from network synchronization and secure communications to GPS hold-over and inertial navigation. A cold-atom coherent population trapping (CACPT) clock featuring laser-cooled atoms and pulsed Ramsey interrogation is a strong candidate for this technology if the principal frequency shifts can be controlled and the performance degradation associated with miniaturization can be overcome. In this thesis, research focused on the development of this type of compact atomic clock is presented. To address the low atom numbers obtained in small cold-atom sources, experiments were performed in which an atomic beam was decelerated with bichromatic stimulated laser forces and loaded into a mm-scale magneto-optical trap, increasing the atom number by a factor of 12.5. A CACPT clock using the high-contrast lin||lin optical interrogation technique was developed and achieved a stability of 7 x 10-13 after one hour of integration. Doppler shifts in the clock are explained using a simple kinematic model and canceled by interrogating the atoms with a counter-propagating CPT configuration. Finally, a thorough characterization of the AC-stark effect in lin||lin CPT was performed. Observed shifts are explained in terms of contributions from coherent CPT-generating couplings and population transfer effects caused by optical pumping from incoherent light. Measurements are compared with existing and new theoretical treatments, and a laser configuration is identified that reduces clock drift from light shifts to less than 10-14 for the current system.

  20. Stability of a trapped atom clock on a chip

    CERN Document Server

    Szmuk, Ramon; Maineult, Wilfried; Reichel, Jakob; Rosenbusch, Peter

    2015-01-01

    We present a compact atomic clock interrogating ultracold 87Rb magnetically trapped on an atom chip. Very long coherence times sustained by spin self-rephasing allow us to interrogate the atomic transition with 85% contrast at 5 s Ramsey time. The clock exhibits a fractional frequency stability of $5.8\\times 10^{-13}$ at 1 s and is likely to integrate into the $1\\times10^{-15}$ range in less than a day. A detailed analysis of 7 noise sources explains the measured frequency stability. Fluctuations in the atom temperature (0.4 nK shot-to-shot) and in the offset magnetic field ($5\\times10^{-6}$ relative fluctuations shot-to-shot) are the main noise sources together with the local oscillator, which is degraded by the 30% duty cycle. The analysis suggests technical improvements to be implemented in a future second generation set-up. The results demonstrate the remarkable degree of technical control that can be reached in an atom chip experiment.

  1. Using Clocks and Atomic Interferometry for Gravity Field Observations

    Science.gov (United States)

    Müller, Jürgen

    2016-07-01

    New technology developed in the frame of fundamental physics may lead to enhanced capabilities for geodetic applications such as refined observations of the Earth's gravity field. Here, we will present new sensor measurement concepts that apply atomic interferometry for gravimetry and clock measurements for observing potential values. In the first case, gravity anomalies can be determined by observing free-falling atoms (quantum gravimetry). In the second case, highly precise optical clocks can be used to measure differences of the gravity potential over long distances (relativistic geodesy). Principally, also inter-satellite ranging between test masses in space with nanometer accuracy belongs to these novel developments. We will show, how the new measurement concepts are connected to classical geodetic concepts, e.g. geopotential numbers and clock readings. We will illustrate the application of these new methods and their benefit for geodesy, where local and global mass variations can be observed with unforeseen accuracy and resolution, mass variations that reflect processes in the Earth system. We will present a few examples where geodesy will potentially benefit from these developments. Thus, the novel technologies might be applied for defining and realizing height systems in a new way, but also for fast local gravimetric surveys and exploration.

  2. Resolved atomic interaction sidebands in an optical clock transition

    CERN Document Server

    Bishof, Michael; Swallows, Matthew D; Gorshkov, Alexey V; Ye, Jun; Rey, Ana Maria

    2011-01-01

    We report the observation of resolved atomic interaction sidebands (ISB) in the ${}^{87}$Sr optical clock transition when atoms at microkelvin temperatures are confined in a two-dimensional (2D) optical lattice. The ISB are a manifestation of the strong interactions that occur between atoms confined in a quasi-one-dimensional geometry and disappear when the confinement is relaxed along one dimension. The emergence of ISB is linked to the recently observed suppression of collisional frequency shifts in [1]. At the current temperatures, the ISB can be resolved but are broad. At lower temperatures, ISB are predicted to be substantially narrower and usable as powerful spectroscopic tools in strongly interacting alkaline-earth gases.

  3. Ultra-stable optical clock with two cold-atom ensembles

    CERN Document Server

    Schioppo, M; McGrew, W F; Hinkley, N; Fasano, R J; Beloy, K; Yoon, T H; Milani, G; Nicolodi, D; Sherman, J A; Phillips, N B; Oates, C W; Ludlow, A D

    2016-01-01

    Atomic clocks based on optical transitions are the most stable, and therefore precise, timekeepers available. These clocks operate by alternating intervals of atomic interrogation with dead time required for quantum state preparation and readout. This non-continuous interrogation of the atom system results in the Dick effect, an aliasing of frequency noise of the laser interrogating the atomic transition. Despite recent advances in optical clock stability achieved by improving laser coherence, the Dick effect has continually limited optical clock performance. Here we implement a robust solution to overcome this limitation: a zero-dead-time optical clock based on the interleaved interrogation of two cold-atom ensembles. This clock exhibits vanishingly small Dick noise, thereby achieving an unprecedented fractional frequency instability of $6 \\times 10^{-17} / \\sqrt{\\tau}$ for an averaging time $\\tau$ in seconds. We also consider alternate dual-atom-ensemble schemes to extend laser coherence and reduce the stan...

  4. Individual Optical Addressing of Atomic Clock Qubits With Stark Shifts

    Science.gov (United States)

    Lee, Aaron; Smith, Jacob; Richerme, Phillip; Neyenhuis, Brian; Hess, Paul; Zhang, Jiehang; Monroe, Chris

    2016-05-01

    In recent years, trapped ions have proven to be a versatile quantum information platform, enabled by their long lifetimes and high gate fidelities. Some of the most promising trapped ion systems take advantage of groundstate hyperfine ``clock'' qubits, which are insensitive to background fields to first order. This same insensitivity also makes σz manipulations of the qubit impractical, eliminating whole classes of operations. We prove there exists a fourth-order light shift, or four-photon Stark shift, of the clock states derived from two coherent laser beams whose beatnote is close to the qubit splitting. Using a mode-locked source generates a large light shift with only modest laser powers, making it a practical σz operation on a clock qubit. We experimentally verify and measure the four-photon Stark shift and demonstrate its use to coherently individually address qubits in a chain of 10 Yb 171 ions with low crosstalk. We use this individual addressing to prepare arbitrary product states with high fidelity and also to apply independent σz terms transverse to an Ising Hamiltonian. This work is supported by the ARO Atomic Physics Program, the AFOSR MURI on Quantum Measurement and Verification, and the NSF Physics Frontier Center at JQI.

  5. Compact atomic clock prototype based on coherent population trapping

    Directory of Open Access Journals (Sweden)

    Danet Jean-Marie

    2014-01-01

    Full Text Available Toward the next generations of compact atomic clocks, clocks based on coherent population trapping (CPT offer a very interesting alternative. Thanks to CPT, a quantum interfering process, this technology has made a decisive step in the miniaturization direction. Fractional frequency stability of 1.5x10-10 at 1 s has been demonstrated in commercial devices of a few cm3. The laboratory prototype presented here intends to explore what could be the ultimate stability of a CPT based device. To do so, an original double-Λ optical scheme and a pulsed interrogation have been implemented in order to get a good compromise between contrast and linewidth. A study of two main sources of noise, the relative intensity and the local oscillator (LO noise, has been performed. By designing simple solutions, it led to a new fractional frequency limitation lower than 4x10-13 at 1 s integration. Such a performance proves that such a technology could rival with classical ones as double resonance clocks.

  6. Atomic clocks: A brief history and current status of research in India

    Indian Academy of Sciences (India)

    Poonam Arora; Amrita Awasthi; Vattikonda Bharath; Aishik Acharya; Suchi Yadav; Aashish Agarwal; Amitava Sen Gupta

    2014-02-01

    Frequency corresponding to the energy difference between designated levels of an atom provides precise reference for making a universally accurate clock. Since the middle of the 20th century till now, there have been tremendous efforts in the field of atomic clocks making time the most accurately measured physical quantity. National Physical Laboratory India (NPLI) is the nation’s timekeeper and is developing an atomic fountain clock which will be a primary frequency standard. The fountain is currently operational and is at the stage of complete frequency evaluation. In this paper, a brief review on atomic time along with some of the recent results from the fountain clock will be discussed.

  7. Development of an atomic clock on an atom chip: Optimisation of the coherence time and preliminary characterisation

    International Nuclear Information System (INIS)

    We describe the construction and preliminary characterization of an atomic clock on an atom chip. A sample of magnetically trapped 87Rb atoms is cooled below 1 μK, close to Bose- Einstein condensation temperature. The trapped states |F = 1; mF = -1> and |F = 2;mF = 1> define our two-photon clock transition. Atoms are trapped around a field B0 = 3.23 G, where the clock frequency is first-order insensitive to magnetic field fluctuations. We have designed an atom chip that includes a microwave coplanar waveguide which drives the 6.835 GHz transition. The whole clock cycle is performed in the vicinity of the chip surface, making the physics package compact (5 cm)3. We first describe the experimental setup of the clock, and the optical bench that has been developed and characterized during this thesis. We then give the results obtained for atom cooling, which led to obtaining a 3 104 atoms Bose-Einstein condensate. We finally present the results obtained by Ramsey spectroscopy of the clock transition. We measure coherence times exceeding 10 seconds with our setup, dominated by atom losses. A preliminary measurement shows that the clock relative frequency stability is of 6 10-12 at 1 s, limited by technical noise. Our goal is to reach a stability in the low 10-13 at 1 s, i.e. better than commercial clocks and competitive with today's best compact clocks. (author)

  8. Microwave interrogation cavity for the rubidium space cold atom clock

    Science.gov (United States)

    Wei, Ren; Yuan-Ci, Gao; Tang, Li; De-Sheng, Lü; Liang, Liu

    2016-06-01

    The performance of space cold atom clocks (SCACs) should be improved thanks to the microgravity environment in space. The microwave interrogation cavity is a key element in a SCAC. In this paper, we develop a microwave interrogation cavity especially for the rubidium SCAC. The interrogation cavity has two microwave interaction zones with a single feed-in source, which is located at the center of the cavity for symmetric coupling excitation and to ensure that the two interaction zones are in phase. The interrogation cavity has a measured resonance frequency of 6.835056471 GHz with a loaded quality factor of nearly 4200, which shows good agreement with simulation results. We measure the Rabi frequency of the clock transition of the rubidium atom in each microwave interaction zone, and subsequently demonstrate that the distributions of the magnetic field in the two interaction zones are the same and meet all requirements of the rubidium SCAC. Project supported by the National Natural Science Foundation of China (Grant No. 11034008), the Fund from the Ministry of Science and Technology of China (Grant No. 2013YQ09094304), and the Youth Innovation Promotion Association, Chinese Academy of Sciences.

  9. Apparatus for fermion atomic clock, atom interferometry and quantum pumping experiments

    Science.gov (United States)

    Ivory, M. K.; Ziltz, A.; Field, J.; Aubin, S.

    2010-03-01

    We present the current state of an apparatus designed to create and manipulate ultracold bosonic and fermionic Rb and K isotopes for a fermion atomic clock, atom interferometry, microwave trapping, and quantum pumping experiments. Quantum pumping is a phenomenon which can precisely control bias-less flow of single electrons in a circuit. Using ultracold atoms on atom chips, we can test theoretical predictions which have not yet been verified due to experimental difficulties in solid state systems. The apparatus design consists of a magneto-optical trap, magnetic transport system, atom chip, and optical dipole trap. We have demonstrated basic laser cooling and trapping and are working towards transport of the collected atoms to the atom chip for cooling to quantum degeneracy. Once quantum degeneracy is achieved at the chip, micro-magnetic reservoirs of ultracold atoms connected by a 1D ``wire'' create a circuit for various quantum pumping schemes. These schemes are also more broadly applicable to atomtronics experiments.

  10. Searching for dilaton dark matter with atomic clocks

    CERN Document Server

    Arvanitaki, Asimina; Van Tilburg, Ken

    2014-01-01

    We propose an experiment to search for ultralight scalar dark matter (DM) with dilatonic interactions. Such couplings can arise for the dilaton as well as for moduli and axion-like particles in the presence of CP violation. Ultralight dilaton DM acts as a background field that can cause tiny but coherent oscillations in Standard Model parameters such as the fine structure constant and the proton-electron mass ratio. These minute variations can be detected through precise frequency comparisons of atomic clocks. Our experiment extends current searches for drifts in fundamental constants to the well-motivated high-frequency regime. Our proposed setups can probe scalars lighter than 10^-15 eV with discovery potential of dilatonic couplings as weak as 10^-11 times the strength of gravity, improving current equivalence principle bounds by up to 8 orders of magnitude. We point out potential 10^4 sensitivity enhancements with future optical and nuclear clocks, as well as possible signatures in gravitational wave dete...

  11. Precision Excited State Lifetime Measurements for Atomic Parity Violation and Atomic Clocks

    Science.gov (United States)

    Sell, Jerry; Patterson, Brian; Gearba, Alina; Snell, Jeremy; Knize, Randy

    2016-05-01

    Measurements of excited state atomic lifetimes provide a valuable test of atomic theory, allowing comparisons between experimental and theoretical transition dipole matrix elements. Such tests are important in Rb and Cs, where atomic parity violating experiments have been performed or proposed, and where atomic structure calculations are required to properly interpret the parity violating effect. In optical lattice clocks, precision lifetime measurements can aid in reducing the uncertainty of frequency shifts due to the surrounding blackbody radiation field. We will present our technique for precisely measuring excited state lifetimes which employs mode-locked ultrafast lasers interacting with two counter-propagating atomic beams. This method allows the timing in the experiment to be based on the inherent timing stability of mode-locked lasers, while counter-propagating atomic beams provides cancellation of systematic errors due to atomic motion to first order. Our current progress measuring Rb excited state lifetimes will be presented along with future planned measurements in Yb.

  12. Frequency Stability of Atomic Clocks Based on Coherent Population Trapping Resonance in 85Rb

    Institute of Scientific and Technical Information of China (English)

    LIU Lu; GUO Tao; DENG Ke; LIU Xin-Yuan; CHEN Xu-Zong; WANG Zhong

    2007-01-01

    An atomic clock system based on coherent population trapping (CPT) resonance in 85Rb is reported, while most past works about the CPT clock are in 87Rb. A new modulation method (full-hyperfine-frequency-splitting modulation) is presented to reduce the effect of light shift to improve the frequency stability of the CPT clock in 85Rb. The experimental results show that the short-term frequency stability of the CPT clock in 85Rb is in the order of 10-10/s and the long-term frequency stability can achieve 1.5 × 10-11 /80000s, which performs as well as 87Rb in CPT resonance. This very good frequency stability performance associated with the low-cost and low-power properties of 85Rb indicates that an atomic clock based on CPT in 85 Rb should be a promising candidate for making the chip scale atomic clock.

  13. Decreasing the uncertainty of atomic clocks via real-time noise distinguish

    CERN Document Server

    Dong, Richang; Wei, Rong; Wang, Wenli; Zou, Fan; Du, Yuanbo; Chen, Tingting; Wang, Yuzhu

    2016-01-01

    The environmental perturbation on atoms is the key factor restricting the performance of atomic frequency standards, especially in long term scale. In this letter, we demonstrate a real-time noise distinguish operation of atomic clocks. The operation improves the statistical uncertainty by about an order of magnitude of our fountain clock which is deteriorated previously by extra noises. The frequency offset bring by the extra noise is also corrected. The experiment proves the real-time noise distinguish operation can reduce the contribution of ambient noises and improve the uncertainty limit of atomic clocks.

  14. A Compact Microchip-Based Atomic Clock Based on Ultracold Trapped Rb Atoms

    CERN Document Server

    Farkas, Daniel M; Anderson, Dana Z

    2009-01-01

    We propose a compact atomic clock based on ultracold Rb atoms that are magnetically trapped near the surface of an atom microchip. An interrogation scheme that combines electromagnetically-induced transparency (EIT) with Ramsey's method of separated oscillatory fields can achieve atomic shot-noise level performance of 10^{-13}/sqrt(tau) for 10^6 atoms. The EIT signal can be detected with a heterodyne technique that provides noiseless gain; with this technique the optical phase shift of a 100 pW probe beam can be detected at the photon shot-noise level. Numerical calculations of the density matrix equations are used to identify realistic operating parameters at which AC Stark shifts are eliminated. By considering fluctuations in these parameters, we estimate that AC Stark shifts can be canceled to a level better than 2*10^{-14}. An overview of the apparatus is presented with estimates of duty cycle and power consumption.

  15. Hyperfine-induced quadrupole moments of alkali-metal atom ground states and their implications for atomic clocks

    CERN Document Server

    Derevianko, Andrei

    2016-01-01

    Spherically-symmetric ground states of alkali-metal atoms do not posses electric quadrupole moments. However, the hyperfine interaction between nuclear moments and atomic electrons distorts the spherical symmetry of electronic clouds and leads to non-vanishing atomic quadrupole moments. We evaluate these hyperfine-induced quadrupole moments using techniques of relativistic many-body theory and compile results for Li, Na, K, Rb, and Cs atoms. For heavy atoms we find that the hyperfine-induced quadrupole moments are strongly (two orders of magnitude) enhanced by correlation effects. We further apply the results of the calculation to microwave atomic clocks where the coupling of atomic quadrupole moments to gradients of electric fields leads to clock frequency uncertainties. We show that for $^{133}$Cs atomic clocks, the spatial gradients of electric fields must be smaller than $30 \\, \\mathrm{V}/\\mathrm{cm}^2$ to guarantee fractional inaccuracies below $10^{-16}$.

  16. Enhancing coherence in molecular spin qubits via atomic clock transitions.

    Science.gov (United States)

    Shiddiq, Muhandis; Komijani, Dorsa; Duan, Yan; Gaita-Ariño, Alejandro; Coronado, Eugenio; Hill, Stephen

    2016-03-17

    Quantum computing is an emerging area within the information sciences revolving around the concept of quantum bits (qubits). A major obstacle is the extreme fragility of these qubits due to interactions with their environment that destroy their quantumness. This phenomenon, known as decoherence, is of fundamental interest. There are many competing candidates for qubits, including superconducting circuits, quantum optical cavities, ultracold atoms and spin qubits, and each has its strengths and weaknesses. When dealing with spin qubits, the strongest source of decoherence is the magnetic dipolar interaction. To minimize it, spins are typically diluted in a diamagnetic matrix. For example, this dilution can be taken to the extreme of a single phosphorus atom in silicon, whereas in molecular matrices a typical ratio is one magnetic molecule per 10,000 matrix molecules. However, there is a fundamental contradiction between reducing decoherence by dilution and allowing quantum operations via the interaction between spin qubits. To resolve this contradiction, the design and engineering of quantum hardware can benefit from a 'bottom-up' approach whereby the electronic structure of magnetic molecules is chemically tailored to give the desired physical behaviour. Here we present a way of enhancing coherence in solid-state molecular spin qubits without resorting to extreme dilution. It is based on the design of molecular structures with crystal field ground states possessing large tunnelling gaps that give rise to optimal operating points, or atomic clock transitions, at which the quantum spin dynamics become protected against dipolar decoherence. This approach is illustrated with a holmium molecular nanomagnet in which long coherence times (up to 8.4 microseconds at 5 kelvin) are obtained at unusually high concentrations. This finding opens new avenues for quantum computing based on molecular spin qubits. PMID:26983539

  17. A New Generation of Atomic Clocks: Accuracy and Stability at the 10^{-18} Level

    CERN Document Server

    Bloom, B J; Williams, J R; Campbell, S L; Bishof, M; Zhang, X; Zhang, W; Bromley, S L; Ye, J

    2013-01-01

    The exquisite control exhibited over quantum states of individual particles has revolutionized the field of precision measurement, as exemplified by the most accurate atomic clock realized in single trapped ions. Whereas many-atom lattice clocks have shown advantages in measurement precision over trapped-ion clocks, their accuracy has remained 20 times worse. Here we demonstrate, for the first time, that a many-atom system achieves accuracy (6x10^{-18}) better than a single ion-based clock, with vastly reduced averaging times (3000 s). This is the first time a single clock has achieved the best performance in all three key ingredients necessary for consideration as a primary standard - stability, reproducibility, and accuracy. This work paves the way for future experiments to integrate many-body quantum state engineering into the frontiers of quantum metrology, creating exciting opportunities to advance precision beyond the standard quantum limit. Improved frequency standards will have impact to a wide range ...

  18. Testing general relativity and alternative theories of gravity with space-based atomic clocks and atom interferometers

    OpenAIRE

    Bondarescu Ruxandra; Schärer Andreas; Jetzer Philippe; Angélil Raymond; Saha Prasenjit; Lundgren Andrew

    2015-01-01

    The successful miniaturisation of extremely accurate atomic clocks and atom interferometers invites prospects for satellite missions to perform precision experiments. We discuss the effects predicted by general relativity and alternative theories of gravity that can be detected by a clock, which orbits the Earth. Our experiment relies on the precise tracking of the spacecraft using its observed tick-rate. The spacecraft's reconstructed four-dimensional trajectory will reveal the nature of gra...

  19. High accuracy measure of atomic polarizability in an optical lattice clock

    CERN Document Server

    Sherman, J A; Hinkley, N; Pizzocaro, M; Fox, R W; Ludlow, A D; Oates, C W

    2011-01-01

    Despite being a canonical example of quantum mechanical perturbation theory, as well as one of the earliest observed spectroscopic shifts, the Stark effect contributes the largest source of uncertainty in a modern optical atomic clock through blackbody radiation. By employing an ultracold, trapped atomic ensemble and high stability optical clock, we characterize the quadratic Stark effect with unprecedented precision. We report the ytterbium optical clock's sensitivity to electric fields (such as blackbody radiation) as the differential static polarizability of the ground and excited clock levels: 36.2612(7) kHz (kV/cm)^{-2}. The clock's fractional uncertainty due to room temperature blackbody radiation is reduced an order of magnitude to 3 \\times 10^{-17}.

  20. Trapping of neutral mercury atoms and prospects for optical lattice clocks.

    Science.gov (United States)

    Hachisu, H; Miyagishi, K; Porsev, S G; Derevianko, A; Ovsiannikov, V D; Pal'chikov, V G; Takamoto, M; Katori, H

    2008-02-01

    We report vapor-cell magneto-optical trapping of Hg isotopes on the (1)S(0)-(3)P(1) intercombination transition. Six abundant isotopes, including four bosons and two fermions, were trapped. Hg is the heaviest nonradioactive atom trapped so far, which enables sensitive atomic searches for "new physics" beyond the standard model. We propose an accurate optical lattice clock based on Hg and evaluate its systematic accuracy to be better than 10;{-18}. Highly accurate and stable Hg-based clocks will provide a new avenue for the research of optical lattice clocks and the time variation of the fine-structure constant. PMID:18352368

  1. Trapping of Neutral Mercury Atoms and Prospects for Optical Lattice Clocks

    CERN Document Server

    Hachisu, H; Porsev, S G; Derevianko, A; Ovsiannikov, V D; Pal'chikov, V G; Takamoto, M; Katori, H

    2007-01-01

    We report a vapor-cell magneto-optical trapping of Hg isotopes on the ${}^1S_0-{}^3P_1$ intercombination transition. Six abundant isotopes, including four bosons and two fermions, were trapped. Hg is the heaviest non-radioactive atom trapped so far, which enables sensitive atomic searches for ``new physics'' beyond the standard model. We propose an accurate optical lattice clock based on Hg and evaluate its systematic accuracy to be better than $10^{-18}$. Highly accurate and stable Hg-based clocks will provide a new avenue for the research of optical lattice clocks and the time variation of the fine-structure constant.

  2. Improvement in medium-long term frequency stability of integrating sphere cold atom clock

    CERN Document Server

    Liu, Peng; Wan, Jinyin; Wang, Xiumei; Wang, Yaning; Xiao, Ling; Cheng, Huadong; Liu, Liang

    2016-01-01

    The medium-long term frequency stability of the integrating sphere cold atom clock was improved.During the clock operation, Rb atoms were cooled and manipulated using cooling light diffusely reflected by the inner surface of a microwave cavity in the clock. This light heated the cavity and caused a frequency drift from the resonant frequency of the cavity. Power fluctuations of the cooling light led to atomic density variations in the cavity's central area, which increased the clock frequency instability through a cavity pulling effect. We overcame these limitations with appropriate solutions. A frequency stability of 3.5E-15 was achieved when the integrating time ? increased to 2E4 s.

  3. An atomic clock with $1\\times 10^{-18}$ room-temperature blackbody Stark uncertainty

    CERN Document Server

    Beloy, K; Phillips, N B; Sherman, J A; Schioppo, M; Lehman, J; Feldman, A; Hanssen, L M; Oates, C W; Ludlow, A D

    2014-01-01

    The Stark shift due to blackbody radiation (BBR) is the key factor limiting the performance of many atomic frequency standards, with the BBR environment inside the clock apparatus being difficult to characterize at a high level of precision. Here we demonstrate an in-vacuum radiation shield that furnishes a uniform, well-characterized BBR environment for the atoms in an ytterbium optical lattice clock. Operated at room temperature, this shield enables specification of the BBR environment to a corresponding fractional clock uncertainty contribution of $5.5 \\times 10^{-19}$. Combined with uncertainty in the atomic response, the total uncertainty of the BBR Stark shift is now $1\\times10^{-18}$. Further operation of the shield at elevated temperatures enables a direct measure of the BBR shift temperature dependence and demonstrates consistency between our evaluated BBR environment and the expected atomic response.

  4. Loading of a fountain clock with an enhanced Low-Velocity Intense Source of atoms

    CERN Document Server

    Dobrev, Georgi; Weyers, Stefan

    2016-01-01

    We present experimental work for improved atom loading in the optical molasses of a caesium fountain clock, employing a low-velocity intense source of atoms (LVIS) [Lu et al., Phys. Rev. Lett. 77, 3331 (1996)], which we modified by adding a "dark" state pump laser. With this modification the atom source has a mean flux of $4 \\times 10^{8}$ atoms/s at a mean atom velocity of $8.6$ m/s. Compared to fountain operation using background gas loading, we achieved a significant increase of the loaded and detected atom number by a factor of 40. Operating the fountain clock with a total number of detected atoms $N_{\\mathrm{at}}=2.9 \\times 10^6$ in the quantum projection noise-limited regime, a frequency instability $\\sigma_y\\left(1\\text{s}\\right)=2.7 \\times 10^{-14}$ was demonstrated.

  5. Loading a fountain clock with an enhanced low-velocity intense source of atoms

    Science.gov (United States)

    Dobrev, G.; Gerginov, V.; Weyers, S.

    2016-04-01

    We present experimental work for improved atom loading in the optical molasses of a cesium fountain clock, employing a low-velocity intense source of atoms [Lu et al., Phys. Rev. Lett 77, 3331 (1996), 10.1103/PhysRevLett.77.3331], which we modify by adding a dark-state pump laser. With this modification the atom source has a mean flux of 4 ×108 atoms/s at a mean atom velocity of 8.6 m/s. Compared to fountain operation using background gas loading, we achieve a significant increase of the loaded and detected atom number by a factor of 40. Operating the fountain clock with a total number of detected atoms Nat=2.9 ×106 in the quantum projection noise-limited regime, a frequency instability σy(1 s ) =2.7 ×10-14 is demonstrated.

  6. Modeling and Estimation of Stationary and Non-stationary Noises of Rubidium Atomic Clock

    Directory of Open Access Journals (Sweden)

    Deepak Mishra,

    2014-07-01

    Full Text Available Noise estimation of atomic clock is one of the important research areas in the field of atomic clock development and application. Most of the atomic clocks are having random-stochastic noises and periodic noises due to temperature variation. Random-stochastic noises have a well identified signature in time domain but periodic noises are difficult to analyze in time domain. However, in this paper, an effort is made to identify and analyze the deterministic trends of both random-stochastic noises and periodic noises due to variation in temperature using an alternate approach of least-squares normalized-error (LSNE regression algorithm. A MATLAB based application with graphical user interface (GUI is developed to estimate and analyze random-stochastic noises and periodic noises and re-estimate the stability of rubidium atomic clock after removing these noises from the raw phase data. The estimation of stationary noises are done using Allan variance from time domain data and noise profile is calculated using curve fit method. The estimation of periodic noises due to temperature variation is carried in frequency domain through spurious analysis of the frequency data of atomic clock.

  7. The Deep Space Atomic Clock: Ushering in a New Paradigm for Radio Navigation and Science

    Science.gov (United States)

    Ely, Todd; Seubert, Jill; Prestage, John; Tjoelker, Robert

    2013-01-01

    The Deep Space Atomic Clock (DSAC) mission will demonstrate the on-orbit performance of a high-accuracy, high-stability miniaturized mercury ion atomic clock during a year-long experiment in Low Earth Orbit. DSAC's timing error requirement provides the frequency stability necessary to perform deep space navigation based solely on one-way radiometric tracking data. Compared to a two-way tracking paradigm, DSAC-enabled one-way tracking will benefit navigation and radio science by increasing the quantity and quality of tracking data. Additionally, DSAC also enables fully-autonomous onboard navigation useful for time-sensitive situations. The technology behind the mercury ion atomic clock and a DSAC mission overview are presented. Example deep space applications of DSAC, including navigation of a Mars orbiter and Europa flyby gravity science, highlight the benefits of DSAC-enabled one-way Doppler tracking.

  8. The Potential of Continuous, Local Atomic Clock Measurements for Earthquake Prediction and Volcanology

    CERN Document Server

    Bondarescu, Mihai; Jetzer, Philippe; Lundgren, Andrew

    2015-01-01

    Modern optical atomic clocks along with the optical fiber technology currently being developed can measure the geoid, which is the equipotential surface that extends the mean sea level on continents, to a precision that competes with existing technology. In this proceeding, we point out that atomic clocks have the potential to not only map the sea level surface on continents, but also look at variations of the geoid as a function of time with unprecedented timing resolution. The local time series of the geoid has a plethora of applications. These include potential improvement in the predictions of earthquakes and volcanoes, and closer monitoring of ground uplift in areas where hydraulic fracturing is performed.

  9. Testing General Relativity and Alternative Theories of Gravity with Space-based Atomic Clocks and Atom Interferometers

    CERN Document Server

    Bondarescu, Ruxandra; Jetzer, Philippe; Angélil, Raymond; Saha, Prasenjit; Lundgren, Andrew

    2015-01-01

    The successful miniaturisation of extremely accurate atomic clocks and atom interferometers invites prospects for satellite missions to perform precision experiments. We discuss the effects predicted by general relativity and alternative theories of gravity that can be detected by a clock, which orbits the Earth. Our experiment relies on the precise tracking of the spacecraft using its observed tick-rate. The spacecraft's reconstructed four-dimensional trajectory will reveal the nature of gravitational perturbations in Earth's gravitational field, potentially differentiating between different theories of gravity. This mission can measure multiple relativistic effects all during the course of a single experiment, and constrain the Parametrized Post-Newtonian Parameters around the Earth. A satellite carrying a clock of fractional timing inaccuracy of $\\Delta f/f \\sim 10^{-16}$ in an elliptic orbit around the Earth would constrain the PPN parameters $|\\beta -1|, |\\gamma-1| \\lesssim 10^{-6}$. We also briefly revi...

  10. DFB-ridge laser diodes at 894 nm for Cesium atomic clocks

    Science.gov (United States)

    von Bandel, N.; Garcia, M.; Lecomte, M.; Larrue, A.; Robert, Y.; Vinet, E.; Driss, O.; Parrilaud, O.; Krakowski, M.; Gruet, F.; Matthey, R.; Mileti, G.

    2016-02-01

    Time and frequency applications are in need of high accuracy and high stability clocks. Optically pumped compact industrial Cesium atomic clocks are a promising approach that could satisfy these demands. However, the stability of these clocks relies, among others, on the performances of the laser diodes that are used. This issue has led the III-V Lab to commit to the European Euripides-LAMA project that aims to provide competitive compact optical Cesium clocks for ground applications. This work will provide key experience for further space technology qualification. III-V Lab is in charge of the design, fabrication and reliability of Distributed-Feedback diodes (DFB) at 894 nm (D1 line of Cesium) and 852 nm (D2 line). LTF-Unine is in charge of their spectral characterisation. The use of D1 line for pumping will provide simplified clock architecture compared to the D2 line pumping thanks to simpler atomic transitions and a larger spectral separation between lines in the 894 nm case. Also, D1 line pumping overcomes the issue of unpumped "idle states" that occur with D2 line. The modules should provide narrow linewidth (= 10 Hz and 109 Hz2/Hz @ f >= 10 Hz.

  11. Atomic fountain clock with very high frequency stability employing a pulse-tube-cryocooled sapphire oscillator.

    Science.gov (United States)

    Takamizawa, Akifumi; Yanagimachi, Shinya; Tanabe, Takehiko; Hagimoto, Ken; Hirano, Iku; Watabe, Ken-ichi; Ikegami, Takeshi; Hartnett, John G

    2014-09-01

    The frequency stability of an atomic fountain clock was significantly improved by employing an ultra-stable local oscillator and increasing the number of atoms detected after the Ramsey interrogation, resulting in a measured Allan deviation of 8.3 × 10(-14)τ(-1/2)). A cryogenic sapphire oscillator using an ultra-low-vibration pulse-tube cryocooler and cryostat, without the need for refilling with liquid helium, was applied as a local oscillator and a frequency reference. High atom number was achieved by the high power of the cooling laser beams and optical pumping to the Zeeman sublevel m(F) = 0 employed for a frequency measurement, although vapor-loaded optical molasses with the simple (001) configuration was used for the atomic fountain clock. The resulting stability is not limited by the Dick effect as it is when a BVA quartz oscillator is used as the local oscillator. The stability reached the quantum projection noise limit to within 11%. Using a combination of a cryocooled sapphire oscillator and techniques to enhance the atom number, the frequency stability of any atomic fountain clock, already established as primary frequency standard, may be improved without opening its vacuum chamber.

  12. Improved spacecraft radio science using an on-board atomic clock: application to gravitational wave searches

    CERN Document Server

    Tinto, Massimo; Prestage, John D; Armstrong, J W

    2008-01-01

    Recent advances in space-qualified atomic clocks (low-mass, low power-consumption, frequency stability comparable to that of ground-based clocks) can enable interplanetary spacecraft radio science experiments at unprecedented Doppler sensitivities. The addition of an on-board digital receiver would allow the up- and down-link Doppler frequencies to be measured separately. Such separate, high-quality measurements allow optimal data combinations that suppress the currently-leading noise sources: phase scintillation noise from the Earth's atmosphere and Doppler noise caused by mechanical vibrations of the ground antenna. Here we provide a general expression for the optimal combination of ground and on-board Doppler data and compute the sensitivity such a system would have to low-frequency gravitational waves (GWs). Assuming a plasma scintillation noise calibration comparable to that already demonstrated with the multi-link CASSINI radio system, the space-clock/digital-receiver instrumentation enhancements would ...

  13. Proposal of a dual-ball atomic fountain clock

    Institute of Scientific and Technical Information of China (English)

    Chunyan Shi; Rong Wei; Zichao Zhou; Tang Li; Yuzhu Wang

    2011-01-01

    @@ A simple improved structure is designed to trap and launch two cold atomic balls vertically at the same time, which works like "two fountains", but is more compact since most components of the "two fountains"are shared.It is expected to improve the stability of the fountain markedly.%A simple improved structure is designed to trap and launch two cold atomic balls vertically at the same time, which works like “two fountains”, but is more compact since most components of the “two fountains”are shared. It is expected to improve the stability of the fountain markedly.

  14. Magnetic field-induced spectroscopy of forbidden optical transitions with application to lattice-based optical atomic clocks.

    Science.gov (United States)

    Taichenachev, A V; Yudin, V I; Oates, C W; Hoyt, C W; Barber, Z W; Hollberg, L

    2006-03-01

    We develop a method of spectroscopy that uses a weak static magnetic field to enable direct optical excitation of forbidden electric-dipole transitions that are otherwise prohibitively weak. The power of this scheme is demonstrated using the important application of optical atomic clocks based on neutral atoms confined to an optical lattice. The simple experimental implementation of this method--a single clock laser combined with a dc magnetic field--relaxes stringent requirements in current lattice-based clocks (e.g., magnetic field shielding and light polarization), and could therefore expedite the realization of the extraordinary performance level predicted for these clocks. We estimate that a clock using alkaline-earth-like atoms such as Yb could achieve a fractional frequency uncertainty of well below 10(-17) for the metrologically preferred even isotopes.

  15. Al-free active region laser diodes at 894 nm for compact Cesium atomic clocks

    Science.gov (United States)

    Von Bandel, N.; Bébé Manga Lobé, J.; Garcia, M.; Larrue, A.; Robert, Y.; Vinet, E.; Lecomte, M.; Drisse, O.; Parillaud, O.; Krakowski, M.

    2015-03-01

    Time-frequency applications are in need of high accuracy and high stability clocks. Compact industrial Cesium atomic clocks optically pumped is a promising area that could satisfy these demands. However, the stability of these clocks relies, among others, on the performances of laser diodes that are used for atomic pumping. This issue has led the III-V Lab to commit to the European Euripides-LAMA project that aims to provide competitive compact optical Cesium clocks for earth applications. This work will provide key experience for further space technology qualification. We are in charge of the design, fabrication and reliability of Distributed-Feedback diodes (DFB) at 894nm (D1 line of Cesium) and 852nm (D2 line). The use of D1 line for pumping will provide simplified clock architecture compared to D2 line pumping thanks to simpler atomic transitions and larger spectral separation between lines in the 894nm case. Also, D1 line pumping overcomes the issue of unpumped "dark states" that occur with D2 line. The modules should provide narrow linewidth (<1MHz), very good reliability in time and, crucially, be insensitive to optical feedback. The development of the 894nm wavelength is grounded on our previous results for 852nm DFB. Thus, we show our first results from Al-free active region with InGaAsP quantum well broad-area lasers (100μm width, with lengths ranging from 2mm to 4mm), for further DFB operation at 894nm. We obtained low internal losses below 2cm-1, the external differential efficiency is 0.49W/A with uncoated facets and a low threshold current density of 190A/cm², for 2mm lasers at 20°C.

  16. Collective non-equilibrium spin exchange in cold alkaline-earth atomic clocks

    Science.gov (United States)

    Acevedo, Oscar Leonardo; Rey, Ana Maria

    2016-05-01

    Alkaline-earth atomic (AEA) clocks have recently been shown to be reliable simulators of two-orbital SU(N) quantum magnetism. In this work, we study the non-equilibrium spin exchange dynamics during the clock interrogation of AEAs confined in a deep one-dimensional optical lattice and prepared in two nuclear levels. The two clock states act as an orbital degree of freedom. Every site in the lattice can be thought as populated by a frozen set of vibrational modes collectively interacting via predominantly p-wave collisions. Due to the exchange coupling, orbital state transfer between atoms with different nuclear states is expected to happen. At the mean field level, we observe that in addition to the expected suppression of population transfer in the presence of a large magnetic field, that makes the single particle levels off-resonance, there is also an interaction induced suppression for initial orbital population imbalance. This suppression resembles the macroscopic self-trapping mechanism seen in bosonic systems. However, by performing exact numerical solutions and also by using the so-called Truncated Wigner Approximation, we show that quantum correlations can significantly modify the mean field suppression. Our predictions should be testable in optical clock experiments. Project supported by NSF-PHY-1521080, JILA-NSF-PFC-1125844, ARO, AFOSR, and MURI-AFOSR.

  17. A compact microchip atomic clock based on all-optical interrogation of ultra-cold trapped Rb atoms

    Science.gov (United States)

    Farkas, D. M.; Zozulya, A.; Anderson, D. Z.

    2010-12-01

    We propose a compact atomic clock that uses all-optical interrogation of ultra-cold Rb atoms that are magnetically trapped near the surface of an atom microchip. The interrogation scheme, which combines electromagnetically induced transparency with Ramsey's method of separated oscillatory fields, can achieve an atomic shot-noise-level performance better than 10^{-13}/sqrt{tau} for 106 atoms. A two-color Mach-Zehnder interferometer can detect a 100-pW probe beam at the optical shot-noise level using conventional photodetectors. This measurement scheme is nondestructive and therefore can be used to increase the operational duty cycle by reusing the trapped atoms for multiple clock cycles. Numerical calculations of the density matrix equations are used to identify realistic operating parameters at which AC Stark shifts are eliminated. By considering fluctuations in these parameters, we estimate that AC Stark shifts can be canceled to a level better than 2×10-14. An overview of the apparatus is presented with estimates of cycle time and power consumption.

  18. Testing general relativity and alternative theories of gravity with space-based atomic clocks and atom interferometers

    Directory of Open Access Journals (Sweden)

    Bondarescu Ruxandra

    2015-01-01

    Full Text Available The successful miniaturisation of extremely accurate atomic clocks and atom interferometers invites prospects for satellite missions to perform precision experiments. We discuss the effects predicted by general relativity and alternative theories of gravity that can be detected by a clock, which orbits the Earth. Our experiment relies on the precise tracking of the spacecraft using its observed tick-rate. The spacecraft’s reconstructed four-dimensional trajectory will reveal the nature of gravitational perturbations in Earth’s gravitational field, potentially differentiating between different theories of gravity. This mission can measure multiple relativistic effects all during the course of a single experiment, and constrain the Parametrized Post-Newtonian Parameters around the Earth. A satellite carrying a clock of fractional timing inaccuracy of Δ f / f ∼ 10−16 in an elliptic orbit around the Earth would constrain the PPN parameters |β − 1|, |γ − 1| ≲ 10−6. We also briefly review potential constraints by atom interferometers on scalar tensor theories and in particular on Chameleon and dilaton models.

  19. The potential of continuous, local atomic clock measurements for earthquake prediction and volcanology

    Directory of Open Access Journals (Sweden)

    Bondarescu Mihai

    2015-01-01

    Full Text Available Modern optical atomic clocks along with the optical fiber technology currently being developed can measure the geoid, which is the equipotential surface that extends the mean sea level on continents, to a precision that competes with existing technology. In this proceeding, we point out that atomic clocks have the potential to not only map the sea level surface on continents, but also look at variations of the geoid as a function of time with unprecedented timing resolution. The local time series of the geoid has a plethora of applications. These include potential improvement in the predictions of earthquakes and volcanoes, and closer monitoring of ground uplift in areas where hydraulic fracturing is performed.

  20. Limits on gravitational Einstein Equivalence Principle violation from monitoring atomic clock frequencies during a year

    CERN Document Server

    Dzuba, V A

    2016-01-01

    Sun's gravitation potential at earth varies during a year due to varying Earth-Sun distance. Comparing the results of very accurate measurements of atomic clock transitions performed at different time in the year allows us to study the dependence of the atomic frequencies on the gravitational potential. We examine the measurement data for the ratio of the frequencies in Hg$^+$ and Al$^+$ clock transitions and absolute frequency measurements (with respect to caesium frequency standard) for Dy, Sr, H, hyperfine transitions in Rb and H, and obtain significantly improved limits on the values of the gravity related parameter of the Einstein Equivalence Principle violating term in the Standard Model Extension Hamiltonian $c_{00} = (3.0 \\pm 5.7) \\times 10^{-7}$ and the parameter for the gravity-related variation of the fine structure constant $\\kappa_{\\alpha} = (-5.3 \\pm 10) \\times 10^{-8}$.

  1. Distinguishing between evidence and its explanations in the steering of atomic clocks

    International Nuclear Information System (INIS)

    Quantum theory reflects within itself a separation of evidence from explanations. This separation leads to a known proof that: (1) no wave function can be determined uniquely by evidence, and (2) any chosen wave function requires a guess reaching beyond logic to things unforeseeable. Chosen wave functions are encoded into computer-mediated feedback essential to atomic clocks, including clocks that step computers through their phases of computation and clocks in space vehicles that supply evidence of signal propagation explained by hypotheses of spacetimes with metric tensor fields. The propagation of logical symbols from one computer to another requires a shared rhythm—like a bucket brigade. Here we show how hypothesized metric tensors, dependent on guesswork, take part in the logical synchronization by which clocks are steered in rate and position toward aiming points that satisfy phase constraints, thereby linking the physics of signal propagation with the sharing of logical symbols among computers. Recognizing the dependence of the phasing of symbol arrivals on guesses about signal propagation transports logical synchronization from the engineering of digital communications to a discipline essential to physics. Within this discipline we begin to explore questions invisible under any concept of time that fails to acknowledge unforeseeable events. In particular, variation of spacetime curvature is shown to limit the bit rate of logical communication. - Highlights: • Atomic clocks are steered in frequency toward an aiming point. • The aiming point depends on a chosen wave function. • No evidence alone can determine the wave function. • The unknowability of the wave function has implications for spacetime curvature. • Variability in spacetime curvature limits the bit rate of communications

  2. Aging studies on micro-fabricated alkali buffer-gas cells for miniature atomic clocks

    International Nuclear Information System (INIS)

    We report an aging study on micro-fabricated alkali vapor cells using neon as a buffer gas. An experimental atomic clock setup is used to measure the cell's intrinsic frequency, by recording the clock frequency shift at different light intensities and extrapolating to zero intensity. We find a drift of the cell's intrinsic frequency of (−5.2 ± 0.6) × 10−11/day and quantify deterministic variations in sources of clock frequency shifts due to the major physical effects to identify the most probable cause of the drift. The measured drift is one order of magnitude stronger than the total frequency variations expected from clock parameter variations and corresponds to a slow reduction of buffer gas pressure inside the cell, which is compatible with the hypothesis of loss of Ne gas from the cell due to its permeation through the cell windows. A negative drift on the intrinsic cell frequency is reproducible for another cell of the same type. Based on the Ne permeation model and the measured cell frequency drift, we determine the permeation constant of Ne through borosilicate glass as (5.7 ± 0.7) × 10−22 m2 s−1 Pa−1 at 81 °C. We propose this method based on frequency metrology in an alkali vapor cell atomic clock setup based on coherent population trapping for measuring permeation constants of inert gases

  3. Distinguishing between evidence and its explanations in the steering of atomic clocks

    Energy Technology Data Exchange (ETDEWEB)

    Myers, John M., E-mail: myers@seas.harvard.edu [Harvard School of Engineering and Applied Sciences, Cambridge, MA 02138 (United States); Hadi Madjid, F., E-mail: gmadjid@aol.com [82 Powers Road, Concord, MA 01742 (United States)

    2014-11-15

    Quantum theory reflects within itself a separation of evidence from explanations. This separation leads to a known proof that: (1) no wave function can be determined uniquely by evidence, and (2) any chosen wave function requires a guess reaching beyond logic to things unforeseeable. Chosen wave functions are encoded into computer-mediated feedback essential to atomic clocks, including clocks that step computers through their phases of computation and clocks in space vehicles that supply evidence of signal propagation explained by hypotheses of spacetimes with metric tensor fields. The propagation of logical symbols from one computer to another requires a shared rhythm—like a bucket brigade. Here we show how hypothesized metric tensors, dependent on guesswork, take part in the logical synchronization by which clocks are steered in rate and position toward aiming points that satisfy phase constraints, thereby linking the physics of signal propagation with the sharing of logical symbols among computers. Recognizing the dependence of the phasing of symbol arrivals on guesses about signal propagation transports logical synchronization from the engineering of digital communications to a discipline essential to physics. Within this discipline we begin to explore questions invisible under any concept of time that fails to acknowledge unforeseeable events. In particular, variation of spacetime curvature is shown to limit the bit rate of logical communication. - Highlights: • Atomic clocks are steered in frequency toward an aiming point. • The aiming point depends on a chosen wave function. • No evidence alone can determine the wave function. • The unknowability of the wave function has implications for spacetime curvature. • Variability in spacetime curvature limits the bit rate of communications.

  4. Hyperfine-induced electric dipole contributions to the electric octupole and magnetic quadrupole atomic clock transitions

    Science.gov (United States)

    Dzuba, V. A.; Flambaum, V. V.

    2016-05-01

    Hyperfine-induced electric dipole contributions may significantly increase probabilities of otherwise very weak electric octupole and magnetic quadrupole atomic clock transitions (e.g., transitions between s and f electron orbitals). These transitions can be used for exceptionally accurate atomic clocks, quantum information processing, and the search for dark matter. They are very sensitive to new physics beyond the standard model, such as temporal variation of the fine-structure constant, the Lorentz invariance, and Einstein equivalence principle violation. We formulate conditions under which the hyperfine-induced electric dipole contribution dominates and perform calculations of the hyperfine structure and E3, M2 and the hyperfine-induced E1 transition rates for a large number of atoms and ions of experimental interest. Due to the hyperfine quenching the electric octupole clock transition in +173Yb is 2 orders of magnitude stronger than that in currently used +171Yb. Some enhancement is found in 13+143Nd, 14+149Pm, 14+147Sm, and 15+147Sm ions.

  5. Trapping of Neutral Mercury Atoms and Prospects for Optical Lattice Clocks

    OpenAIRE

    Hachisu, H.; Miyagishi, K.; Porsev, S. G.; Derevianko, A.; Ovsiannikov, V. D.; Pal'chikov, V. G.; Takamoto, M.; Katori, H.

    2007-01-01

    We report a vapor-cell magneto-optical trapping of Hg isotopes on the ${}^1S_0-{}^3P_1$ intercombination transition. Six abundant isotopes, including four bosons and two fermions, were trapped. Hg is the heaviest non-radioactive atom trapped so far, which enables sensitive atomic searches for ``new physics'' beyond the standard model. We propose an accurate optical lattice clock based on Hg and evaluate its systematic accuracy to be better than $10^{-18}$. Highly accurate and stable Hg-based ...

  6. Quantum projection noise limited stability of a 88Sr+ atomic clock

    Science.gov (United States)

    Jian, B.; Dubé, P.; Madej, A. A.

    2016-06-01

    The evaluated accuracy of a single trapped 88Sr+ ion clock referenced to the 5s2 S 1/2 - 4d 2 D 5/2 transition at 445 THz at the National Research Council of Canada has reached 1.2 x 10-17 over recent years. On the other hand, the stability of an atomic clock determines how long the signals from two similar clocks have to be compared to reach a given level of uncertainty. Here, we report on the improvement of the stability of NRC's 88Sr+ single ion clock by reducing the Allan deviation from 1 x 10-14 to 3 x 10-15 at 1 second averaging time. This is done by the implementation of a clear out laser that transfers the ion from the metastable state to the ground state at each cycle, followed by a state-preparation step that transfers the ion to the desired ground state magnetic sublevel of the probed transition.

  7. Optical lattice clock with strontium atoms: a second generation of cold atom clocks; Horloge a reseau optique au strontium: une 2. generation d'horloges a atomes froids

    Energy Technology Data Exchange (ETDEWEB)

    Le Targat, R

    2007-07-15

    Atomic fountains, based on a microwave transition of Cesium or Rubidium, constitute the state of the art atomic clocks, with a relative accuracy close to 10{sup -16}. It nevertheless appears today that it will be difficult to go significantly beyond this level with this kind of device. The use of an optical transition, the other parameters being unchanged, gives hope for a 4 or 5 orders of magnitude improvement of the stability and of the relative uncertainty on most systematic effects. As for motional effects on the atoms, they can be controlled on a very different manner if they are trapped in an optical lattice instead of experiencing a free ballistic flight stage, characteristic of fountains. The key point of this approach lies in the fact that the trap can be operated in such a way that a well chosen, weakly allowed, J=0 {yields} J=0 clock transition can be free from light shift effects. In this respect, the strontium atom is one of the most promising candidate, the 1S{sub 0} {yields} 3P{sub 0} transition has a natural width of 1 mHz, and several other easily accessible transitions can be used to efficiently laser cool atoms down to 10 {mu}K. This thesis demonstrates the experimental feasibility of an optical lattice clock based on the strontium atom, and reports on a preliminary evaluation of the relative accuracy with the fermionic isotope {sup 87}Sr, at a level of a few 10{sup -15}. (author)

  8. A highly miniaturized vacuum package for a trapped ion atomic clock

    Science.gov (United States)

    Schwindt, Peter D. D.; Jau, Yuan-Yu; Partner, Heather; Casias, Adrian; Wagner, Adrian R.; Moorman, Matthew; Manginell, Ronald P.; Kellogg, James R.; Prestage, John D.

    2016-05-01

    We report on the development of a highly miniaturized vacuum package for use in an atomic clock utilizing trapped ytterbium-171 ions. The vacuum package is approximately 1 cm3 in size and contains a linear quadrupole RF Paul ion trap, miniature neutral Yb sources, and a non-evaporable getter pump. We describe the fabrication process for making the Yb sources and assembling the vacuum package. To prepare the vacuum package for ion trapping, it was evacuated, baked at a high temperature, and then back filled with a helium buffer gas. Once appropriate vacuum conditions were achieved in the package, it was sealed with a copper pinch-off and was subsequently pumped only by the non-evaporable getter. We demonstrated ion trapping in this vacuum package and the operation of an atomic clock, stabilizing a local oscillator to the 12.6 GHz hyperfine transition of 171Y b+. The fractional frequency stability of the clock was measured to be 2 × 10-11/τ1/2.

  9. Inner-shell magnetic dipole transition in Tm atom as a candidate for optical lattice clocks

    CERN Document Server

    Sukachev, D; Tolstikhina, I; Kalganova, E; Vishnyakova, G; Khabarova, K; Tregubov, D; Golovizin, A; Sorokin, V; Kolachevsky, N

    2016-01-01

    We consider a narrow magneto-dipole transition in the $^{169}$Tm atom at the wavelength of $1.14\\,\\mu$m as a candidate for a 2D optical lattice clock. Calculating dynamic polarizabilities of the two clock levels $[\\text{Xe}]4f^{13}6s^2 (J=7/2)$ and $[\\text{Xe}]4f^{13}6s^2 (J=5/2)$ in the spectral range from $250\\,$nm to $1200\\,$nm, we suggest the "magic" wavelength for the optical lattice at $807\\,$nm. Frequency shifts due to black-body radiation (BBR), the van der Waals interaction, the magnetic dipole-dipole interaction and other effects which can perturb the transition frequency are calculated. The transition at $1.14\\,\\mu$m demonstrates low sensitivity to the BBR shift corresponding to $8\\times10^{-17}$ in fractional units at room temperature which makes it an interesting candidate for high-performance optical clocks. The total estimated frequency uncertainty is less than $5 \\times 10^{-18}$ in fractional units. By direct excitation of the $1.14\\,\\mu$m transition in Tm atoms loaded into an optical dipole ...

  10. Status of the atomic fountain clock at the National Research Council of Canada

    Science.gov (United States)

    Beattie, S.; Alcock, J.; Jian, B.; Gertsvolf, M.; Bernard, J.

    2016-06-01

    Despite the rapid advances in optical frequency standards, caesium fountain clocks retain a critical role as the most accurate primary frequency standards available. At the National Research Council Canada, we are working to develop a second generation caesium fountain clock. Work is currently underway to improve several systems of FCs1, such as the laser system and microwave local oscillator, which will be incorporated into its refurbished version, FCs2. In addition, we have added an optical pumping stage which has increased the detected atom number by over a factor of six. In collaboration with the National Physical Laboratory (NPL), we are planning on replacing the physics package of FCs1. We will report on several recent improvements to FCs1, along with our progress in the development of FCs2.

  11. Composite pulses in Hyper-Ramsey spectroscopy for the next generation of atomic clocks

    CERN Document Server

    Zanon-Willette, T; Yudin, V I; Taichenachev, A V

    2016-01-01

    The next generation of atomic frequency standards based on an ensemble of neutral atoms or a single-ion will provide very stringent tests in metrology, applied and fundamental physics requiring a new step in very precise control of external systematic corrections. In the proceedings of the 8th Symposium on Frequency Standards and Metrology, we present a generalization of the recent Hyper-Ramsey spectroscopy with separated oscillating fields using composites pulses in order to suppress field frequency shifts induced by the interrogation laser itself. Sequences of laser pulses including specific selection of phases, frequency detunings and durations are elaborated to generate spectroscopic signals with a strong reduction of the light-shift perturbation by off resonant states. New optical clocks based on weakly allowed or completely forbidden transitions in atoms, ions, molecules and nuclei will benefit from these generalized Ramsey schemes to reach relative accuracies well below the 10$^{-18}$ level.

  12. Composite pulses in Hyper-Ramsey spectroscopy for the next generation of atomic clocks

    Science.gov (United States)

    Zanon-Willette, T.; Minissale, M.; Yudin, V. I.; Taichenachev, A. V.

    2016-06-01

    The next generation of atomic frequency standards based on an ensemble of neutral atoms or a single-ion will provide very stringent tests in metrology, applied and fundamental physics requiring a new step in very precise control of external systematic corrections. In the proceedings of the 8th Symposium on Frequency Standards and Metrology, we present a generalization of the recent Hyper-Ramsey spectroscopy with separated oscillating fields using composites pulses in order to suppress field frequency shifts induced by the interrogation laser itself. Sequences of laser pulses including specific selection of phases, frequency detunings and durations are elaborated to generate spectroscopic signals with a strong reduction of the light-shift perturbation by off resonant states. New optical clocks based on weakly allowed or completely forbidden transitions in atoms, ions, molecules and nuclei will benefit from these generalized Ramsey schemes to reach relative accuracies well below the 10-18 level.

  13. Automatic compensation of magnetic field for a rubidium space cold atom clock

    Science.gov (United States)

    Lin, Li; Jingwei, Ji; Wei, Ren; Xin, Zhao; Xiangkai, Peng; Jingfeng, Xiang; Desheng, Lü; Liang, Liu

    2016-07-01

    When the cold atom clock operates in microgravity around the near-earth orbit, its performance will be affected by the fluctuation of magnetic field. A strategy is proposed to suppress the fluctuation of magnetic field by additional coils, whose current is changed accordingly to compensate the magnetic fluctuation by the linear and incremental compensation. The flight model of the cold atom clock is tested in a simulated orbital magnetic environment and the magnetic field fluctuation in the Ramsey cavity is reduced from 17 nT to 2 nT, which implied the uncertainty due to the second order Zeeman shift is reduced to be less than 2×10-16. In addition, utilizing the compensation, the magnetic field in the trapping zone can be suppressed from 7.5 μT to less than 0.3 μT to meet the magnetic field requirement of polarization gradients cooling of atoms. Project supported by the Ministry of Science and Technology of China (Grant No. 2013YQ09094304), the Youth Innovation Promotion Association, Chinese Academy of Sciences, and the National Natural Science Foundation of China (Grant Nos. 11034008 and 11274324).

  14. Some theoretical aspects of the group-IIIA-ion atomic clocks: Intercombination transition probabilities

    International Nuclear Information System (INIS)

    The main focus of this paper is the theoretical study of the 3P1→1S0 intercombination transition probabilities of the group-IIIA ions that are excellent candidates for high-accuracy atomic clocks. The importance of relativistic effects on the intercombination transition probabilities is made apparent by comparing their calculated values with those of the allowed 1P1→1S0 transition probabilities. In striking contrast to the allowed transition probabilities, the intercombination transition probabilities exhibit a strong Z dependence

  15. δ-electron spectroscopy and the atomic clock effect in heavy-ion collisions

    International Nuclear Information System (INIS)

    The properties of strongly bound electrons in superheavy quasimolecular systems with combined nuclear charge numbers Z = ZP + ZT ≥ 110 are investigated. The emission of δ-electrons may serve as an atomic clock for nuclear reactions which is associated with the large overlap of the electron probability density with the nuclear interior. Excitation and emission rates of inner-shell electrons in collisions of very heavy ions with beam energies at or above the nuclear Coulomb barrier depend explicitly on details of the nuclear dynamics. Theoretical and experimental results are reviewed. (orig.)

  16. Role of the multipolar black-body radiation shifts in the atomic clocks at the 10-18 uncertainty level

    Indian Academy of Sciences (India)

    B K Sahoo

    2014-08-01

    We present here an overview of the role of the multipolar black-body radiation (BBR) shifts in the single ion atomic clocks to appraise the anticipated 10-18 uncertainty level. With an attempt to use the advanced technologies for reducing the instrumental uncertainties at the unprecedented low, it is essential to investigate contributions from the higher-order systematics to achieve the ambitious goal of securing the most precise clock frequency standard. In this context, we have analysed contributions to the BBR shifts from the multipolar polarizabilities in a few ion clocks.

  17. Improved limits on interactions of low-mass spin-0 dark matter from atomic clock spectroscopy

    Science.gov (United States)

    Stadnik, Y. V.; Flambaum, V. V.

    2016-08-01

    Low-mass (sub-eV) spin-0 dark matter particles, which form a coherently oscillating classical field ϕ =ϕ0cos(mϕt ) , can induce oscillating variations in the fundamental constants through their interactions with the standard model sector. We calculate the effects of such possible interactions, which may include the linear interaction of ϕ with the Higgs boson, on atomic and molecular transitions. Using recent atomic clock spectroscopy measurements, we derive limits on the linear interaction of ϕ with the Higgs boson, as well as its quadratic interactions with the photon and light quarks. For the linear interaction of ϕ with the Higgs boson, our derived limits improve on existing constraints by up to 2-3 orders of magnitude.

  18. Microfabricated cells for chip-scale atomic clock based on coherent population trapping: Fabrication and investigation

    Directory of Open Access Journals (Sweden)

    S.V. Ermak

    2015-03-01

    Full Text Available A universal method for fabrication of miniature cells for frequency standards and quantum magnetometers containing 87Rb atoms in the atmosphere of inert gas neon based on integrated technologies is considered. The results of experimental studies of coherent population trapping signals observed for a series of cells which provided recovery of vapors of an alkali metal from the rubidium dichromate salt with the help of laser radiation are presented. The coherent population trapping signals with a typical linewidth of 2–3 kHz and a signal-to-noise ratio of 1500 in the 1-Hz bandwidth were observed, which allows one to provide a relative frequency stability of atomic clock of 10−11 at 100 s.

  19. Effects of variation of fundamental constants from Big Bang to atomic clocks

    Science.gov (United States)

    Flambaum, Victor

    2004-05-01

    Theories unifying gravity with other interactions suggest temporal and spatial variation of the fundamental "constants" in expanding Universe. I discuss effects of variation of the fine structure constant, strong interaction, quark mass and gravitational constant. The measurements of these variations cover the lifespan of the Universe from few minutes after Big Bang to the present time and give controversial results. There are some hints for the variations in Big Bang nucleosynthesis, quasar absorption spectra and Oklo natural nuclear reactor data. A very promising method to search for the variation of the fundamental constants consists in comparison of different atomic clocks. A billion times enhancement of the variation effects happens in transitions between accidentally degenerate atomic energy levels.

  20. Atom interferometers and optical atomic clocks: New quantum sensors for fundamental physics experiments in space

    International Nuclear Information System (INIS)

    We present projects for future space missions using new quantum devices based on ultracold atoms. They will enable fundamental physics experiments testing quantum physics, physics beyond the standard model of fundamental particles and interactions, special relativity, gravitation and general relativity

  1. Explaining atomic clock behavior in a gravitational field with only 1905 Relativity

    CERN Document Server

    Hidalgo-Gato, Rafael A Valls

    2010-01-01

    Supported only in the two 1905 Einstein's papers on Relativity and a very rigid respect for the historical context, an analysis is done of the derivation of the universal mass-energy relationship. It is found, contrary to the today accepted Physics knowledge, that a body's Rest Mass measures its Potential Energy in the 1905 context. After emphasizing the difference between 1905 Relativity (1905R) and Special Relativity (SR), the developing of a 1905R relativistic gravity is started for a small mass m material point moving in the central gravitational field of a great mass M one. A formula for the rest mass m_0 as a function of its distance r from M is obtained. Finally, those results are applied to an atomic clock in a gravitational field, reaching a factor to obtain the clock time rate change very close to the GR one. The factors from 1905R and GR are compared, emphasizing the absent of a singularity in 1905R. In the conclusions, a new road for the development of a 1905R relativistic mechanics is declared, r...

  2. Measurement of the magnetic field profile in the atomic fountain clock FoCS-2 using Zeeman spectroscopy

    CERN Document Server

    Laurent, Devenoges; André, Stefanov; Antoine, Jallageas; Jacques, Morel; Thomas, Südmeyer; Pierre, Thomann

    2016-01-01

    We report the evaluation of the second order Zeeman shift in the continuous atomic fountain clock FoCS-2. Because of the continuous operation and its geometrical constraints, the methods used in pulsed fountain are not applicable. We use here time-resolved Zeeman spectroscopy to probe the magnetic field profile in the clock. The pulses of ac magnetic excitation allow us to measure the Zeeman frequency with spatial resolution and to evaluate the Zeeman shift with an uncertainty smaller than 10E-16 in relative units.

  3. First observation of the strongly forbidden transition 1S0 - 3P0 in Strontium, for an atomic clock with trapped atoms

    International Nuclear Information System (INIS)

    This thesis reports the first results towards the realization of an optical clock using trapped strontium atoms. This set up would combine advantages of the different approaches commonly used to develop an atomic frequency standard. The first part describes the cold atoms source which is implemented. A magneto-optical trap operating on the 1S0-1P1 transition at 461 nm is loaded from an atomic beam decelerated by a Zeeman slower. The 461 nm laser is obtained by sum-frequency mixing in a potassium titanyl phosphate (KTP) crystal. The second part is devoted to the different stages developed to achieve the direct excitation of the 1S0-3P0 clock transition in 87Sr. This line has a theoretical natural width of 10-3 Hz. Before this detection, we obtained an estimate of the resonance frequency by measuring absolute frequencies of several allowed optical transitions. (author)

  4. 原子钟、原子弹哪个更重要%Which one is more important, Atomic Bomb or Atomic Clock?

    Institute of Scientific and Technical Information of China (English)

    李滚; 蔡成林; 袁海波

    2003-01-01

    @@ 1945年原子弹(Atomic Bomb)在广岛长崎爆炸之前,一般人很难理解原子弹的威力,原子钟(Atomic Clock)也不是大家都能一睹为快的;但是,原子弹和原子钟的概念的确已是家喻户晓.

  5. Effect of Irregularities in the Earth's Rotation on Relativistic Shifts in Frequency and Time of Earthbound Atomic Clocks

    Science.gov (United States)

    Fateev, V. F.; Kopeikin, S. M.; Pasynok, S. L., S. L.

    2015-10-01

    The effect of irregularities in the earth's rotation (precession and nutation of the earth's axis of rotation, oscillations in the modulus of the angular velocity, periodic deviations in the line of the poles, and the angular momentum of the globe) on the frequency and time of high-stability atomic clocks are examined in terms of the theory of relativity. It is shown that the relative shift in frequency and time owing to these effects can exceed 5×10-16.

  6. A low phase noise microwave frequency synthesis for a high-performance cesium vapor cell atomic clock

    Energy Technology Data Exchange (ETDEWEB)

    François, B.; Boudot, R. [FEMTO-ST, CNRS, Université de Franche-Comté, 26 chemin de l' Epitaphe, 25030 Besançon (France); Calosso, C. E. [INRIM, Strada delle Cacce 91, 10135 Torino (Italy); Danet, J. M. [LNE-SYRTE, Observatoire de Paris, CNRS-UPMC, 61 avenue de l' Observatoire, 75014 Paris (France)

    2014-09-15

    We report the development, absolute phase noise, and residual phase noise characterization of a 9.192 GHz microwave frequency synthesis chain devoted to be used as a local oscillator in a high-performance cesium vapor cell atomic clock based on coherent population trapping (CPT). It is based on frequency multiplication of an ultra-low phase noise 100 MHz oven-controlled quartz crystal oscillator using a nonlinear transmission line-based chain. Absolute phase noise performances of the 9.192 GHz output signal are measured to be −42, −100, −117 dB rad{sup 2}/Hz and −129 dB rad{sup 2}/Hz at 1 Hz, 100 Hz, 1 kHz, and 10 kHz offset frequencies, respectively. Compared to current results obtained in a state-of-the-art CPT-based frequency standard developed at LNE-SYRTE, this represents an improvement of 8 dB and 10 dB at f = 166 Hz and f = 10 kHz, respectively. With such performances, the expected Dick effect contribution to the atomic clock short term frequency stability is reported at a level of 6.2 × 10{sup −14} at 1 s integration time, that is a factor 3 higher than the atomic clock shot noise limit. Main limitations are pointed out.

  7. Atomic clocks based on extened-cavity diode laser in multimode operation

    Science.gov (United States)

    Yim, Sin; Cho, D.

    2011-05-01

    We demonstrated the possibilities to develope an atomic clock based on coherent population trapping (CPT) without using a local oscillator and a modulator. Instead of using a modulator, we use two modes from a single extended-cavity diode laser in multimode operation. Two different types of feedback system are applied to stabilize a difference frequency between the two modes and eliminate the need for an extra frequency modulation. In the first type, we employ an electronic feedback using dispersion of the CPT resonance as an error signal. The two modes are phase locked with reference to a dispersion signal from a CPT resonance of 85Rb at 3.036 GHz ground hyperfine splitting. We use D1 transition at 794.8 nm with lin ⊥lin polarizations to obtain large-contrast CPT signal. Allan deviation of the beat frequency between the two modes is 1 ×10-10 at 200-s integration time. In the second type, we employ optoelectronic feedback to construct an opto-electronic oscillator (OEO). In an OEO, the beating signal between two modes is recovered by a fast photodiode, and its output is amplified and fed back to the laser diode by using a direct modulation of an injection current. When the OEO loop is closed, oscillation frequency depends on variations of the loop length. In order to stabilize an OEO loop length and thereby its oscillation frequency, CPT cell is inserted to play a role of microwave band pass filter. Allan deviation of the CPT-stabilized OEO is 2 ×10-10 at 100-s integration time.

  8. Reliability characteristics of microfabricated Rb mini-lamps for optical pumping in miniature atomic clocks and magnetometers

    Science.gov (United States)

    Venkatraman, Vinu; Pétremand, Yves; de Rooij, Nico; Shea, Herbert

    2013-03-01

    With the rising need for microfabricated chip-scale atomic clocks to enable high precision timekeeping in portable applications, there has been active interest in developing miniature (pumping in double-resonance clocks. We reported in 2012 a first microfabricated chip-scale Rubidium dielectric barrier discharge lamp. The device's preliminary results indicated its high potential for optical pumping applications and wafer-scale batch fabrication. The chip-scale plasma light sources were observed to be robust with no obvious performance change after thousands of plasma ignitions, and with no electrode erosion from plasma discharges since the electrodes are external. However, as atomic clocks have strict lamp performance requirements including less than 0.1% sub-second optical power fluctuations, power consumption less than 20 mW and a device lifetime of at least several years, it is important to understand the long-term reliability of these Rb planar mini-lamps, and identify the operating conditions where these devices can be most reliable and stable. In this paper, we report on the reliability of such microfabricated lamps including a continuous several month run of the lamp where the optical power, electrical power consumption and temperature stability were continuously monitored. We also report on the effects of temperature, rf-power and the lamp-drive parasitics on the optical power stability and discuss steps that could be taken to further improve the device's performance and reliability.

  9. Formulation of geopotential difference determination using optical-atomic clocks onboard satellites and on ground based on Doppler cancellation system

    Science.gov (United States)

    Shen, Ziyu; Shen, Wen-Bin; Zhang, Shuangxi

    2016-06-01

    In this study we propose an approach for determining the geopotential difference using high-frequency-stability microwave links between satellite and ground station based on Doppler cancelation system. Suppose a satellite and a ground station are equipped with precise optical-atomic clocks and oscillators. The ground oscillator emits a signal with frequency fa towards the satellite and the satellite receiver (connected with the satellite oscillator) receives this signal with frequency fb which contains the gravitational frequency shift effect and other signals and noises. After receiving this signal, the satellite oscillator transmits and emits respectively two signals with frequencies fb and fc towards the ground station. Via Doppler cancellation technique, the geopotential difference between the satellite and the ground station can be determined based on gravitational frequency shift equation by a combination of these three frequencies. For arbitrary two stations on ground, based on similar procedures as described above, we may determine the geopotential difference between these two stations via a satellite. Our analysis shows that the accuracy can reach 1 {m^2/s^2} based on the clocks' inaccuracy of about 10-17 (s/s) level. Since optical-atomic clocks with instability around 10-18 in several hours and inaccuracy around 10-18 level have been generated in laboratory, the proposed approach may have prospective applications in geoscience, and especially, based on this approach a unified world height system could be realized with one-centimeter level accuracy in the near future.

  10. Precision Clock Evaluation Facility

    Data.gov (United States)

    Federal Laboratory Consortium — FUNCTION: Tests and evaluates high-precision atomic clocks for spacecraft, ground, and mobile applications. Supports performance evaluation, environmental testing,...

  11. Accuracy budget of the 88Sr optical atomic clocks at KL FAMO

    Science.gov (United States)

    Radzewicz, Czesław; Bober, Marcin; Morzyński, Piotr; Cygan, Agata; Lisak, Daniel; Bartoszek-Bober, Dobrosława; Masłowski, Piotr; Ablewski, Piotr; Zachorowski, Jerzy; Gawlik, Wojciech; Ciuryło, Roman; Zawada, Michał

    2016-08-01

    This paper presents a detailed accuracy budget of two independent strontium optical lattice clocks at the National Laboratory FAMO (KL FAMO) probed with a single shared ultra-narrow laser. The combined instability of the two frequency standards was 7× {10}-17 after 105s of averaging.

  12. Dynamic polarizabilities and related properties of clock states of ytterbium atom

    CERN Document Server

    Dzuba, V A

    2009-01-01

    We carry out relativistic many-body calculations of the static and dynamic dipole polarizabilities of the ground $6s^2 ^1S_0$ and the first excited $6s6p ^3P^o_0$ states of Yb. With these polarizabilities, we compute several properties of Yb relevant to optical lattice clocks operating on the $6s^2 ^1S_0 - 6s6p ^3P^o_0$ transition. We determine (i) the first four {\\em magic} wavelengths of the laser field for which the frequency of the clock transition is insensitive to the laser intensity. While the first magic wavelength is known, we predict the second, the third and the forth magic wavelengths to be 551 nm, 465 nm, and 413 nm. (ii) We reevaluate the effect of black-body radiation on the frequency of the clock transition, the resulting clock shift at $T=300 \\mathrm{K}$ being $-1.41(17)$ Hz. (iii) We compute long-range interatomic van der Waals coefficients (in a.u.) $C_6(6s^2 ^1S_0 +6s^2 ^1S_0) = 1909(160)$, $C_6(6s^2 ^1S_0 + 6s6p ^3P_0) =2709(338) $, and $C_6(6s6p ^3P_0 + 6s6p ^3P_0) =3886(360) $. Finally,...

  13. A CPT-based Cs vapor cell atomic clock with a short-term fractional frequency stability of 3 x 10-13 τ-1/2

    Science.gov (United States)

    Abdel Hafiz, Moustafa; Liu, Xiaochi; Guérandel, Stéphane; De Clercq, Emeric; Boudot, Rodolphe

    2016-06-01

    This article reports on the development and short-term fractional frequency stability of a continuous-regime (CW) Cs vapor cell atomic clock based on coherent population trapping (CPT). The push-pull optical pumping technique is used to increase the number of atoms that participate to the clock transition, yielding a typical CPT resonance contrast of 25% for a CPT linewidth of about 450 Hz. The clock short-term fractional frequency stability is measured to be 3 x 10-13 τ-1/2 up to 100 seconds averaging time, in correct agreement with the signal-to-noise ratio limit. The mid-term frequency stability results are currently mainly limited by laser power effects. The detection of high-contrast narrow Raman-Ramsey fringes is demonstrated with this setup by making the atoms interact with a light pulse sequence.

  14. Stable clocks and general relativity

    CERN Document Server

    Will, C M

    1995-01-01

    We survey the role of stable clocks in general relativity. Clock comparisons have provided important tests of the Einstein Equivalence Principle, which underlies metric gravity. These include tests of the isotropy of clock comparisons (verification of local Lorentz invariance) and tests of the homogeneity of clock comparisons (verification of local position invariance). Comparisons of atomic clocks with gravitational clocks test the Strong Equivalence Principle by bounding cosmological variations in Newton's constant. Stable clocks also play a role in the search for gravitational radiation: comparision of atomic clocks with the binary pulsar's orbital clock has verified gravitational-wave damping, and phase-sensitive detection of waves from inspiralling compact binaries using laser interferometric gravitational observatories will facilitate extraction of useful source information from the data. Stable clocks together with general relativity have found important practical applications in navigational systems s...

  15. A New Rb Lamp Exciter Circuit for Rb atomic clocks and Studies on Transition from Ring to Red mode

    CERN Document Server

    Singh, Savita; Saxena, G M

    2010-01-01

    In this paper we describe the development of novel RF exciter circuit for electrode less Rb lamp. The lamp exciter circuit is a RF oscillator with a a new configuration operating at 60 to 65 MHz frequency with 3 to 4 watt power. The Rb lamp is used in exciting the ground state hyperfine transitions in Rb atom in a glass cell placed inside a tuned microwave cavity, As the frequency of these hyperfine transitions is very stable it is used in the development of Rb atomic clock by phase locking the oven controlled crystal oscillator (OCXO) to this atomic transition frequency. The details of the Rb lamp exciter are presented in the paper.The Lamp is ideally operated in ring mode as in this mode the linewidth is narrow and there is no self reversal. However, high temperature and RF excitation power may drive the Rb lamp to red mode which gives rise to line broadening and self reversal. It is the experience that mode change from ring to red deteriorates the atomic signal strength and S/N. In this paper the reasons o...

  16. Formulation of geopotential difference determination using optical-atomic clocks onboard satellites and on ground based on Doppler cancellation system

    Science.gov (United States)

    Shen, Ziyu; Shen, Wen-Bin; Zhang, Shuangxi

    2016-08-01

    In this study, we propose an approach for determining the geopotential difference using high-frequency-stability microwave links between satellite and ground station based on Doppler cancellation system. Suppose a satellite and a ground station are equipped with precise optical-atomic clocks (OACs) and oscillators. The ground oscillator emits a signal with frequency fa towards the satellite and the satellite receiver (connected with the satellite oscillator) receives this signal with frequency fb which contains the gravitational frequency shift effect and other signals and noises. After receiving this signal, the satellite oscillator transmits and emits, respectively, two signals with frequencies fb and fc towards the ground station. Via Doppler cancellation technique, the geopotential difference between the satellite and the ground station can be determined based on gravitational frequency shift equation by a combination of these three frequencies. For arbitrary two stations on ground, based on similar procedures as described above, we may determine the geopotential difference between these two stations via a satellite. Our analysis shows that the accuracy can reach 1 m2 s- 2 based on the clocks' inaccuracy of about 10-17 (s s-1) level. Since OACs with instability around 10-18 in several hours and inaccuracy around 10-18 level have been generated in laboratory, the proposed approach may have prospective applications in geoscience, and especially, based on this approach a unified world height system could be realized with one-centimetre level accuracy in the near future.

  17. Active optical clock

    Institute of Scientific and Technical Information of China (English)

    CHEN JingBiao

    2009-01-01

    This article presents the principles and techniques of active optical clock, a special laser combining the laser physics of one-atom laser, bad-cavity gas laser, super-cavity stabilized laser and optical atomic clock together. As a simple example, an active optical clock based on thermal strontium atomic beam shows a quantum-limited linewidth of 0.51 Hz, which is insensitive to laser cavity-length noise, and may surpass the recorded narrowest 6.7 Hz of Hg ion optical clock and 1.5 Hz of very recent optical lattice clock. The estimated 0.1 Hz one-second instability and 0.27 Hz uncertainty are limited only by the rela-tivistic Doppler effect, and can be improved by cold atoms.

  18. Compact Yb$^+$ optical atomic clock project: design principle and current status

    CERN Document Server

    Lacroûte, Clément; Bourgeois, Pierre-Yves; Millo, Jacques; Saleh, Khaldoun; Bigler, Emmanuel; Boudot, Rodolphe; Giordano, Vincent; Kersalé, Yann

    2016-01-01

    We present the design of a compact optical clock based on the $^2S_{1/2} \\rightarrow ^2D_{3/2}$ 435.5 nm transition in $^{171}$Yb$^+$. The ion trap will be based on a micro-fabricated circuit, with surface electrodes generating a trapping potential to localize a single Yb ion a few hundred $\\mu$m from the electrodes. We present our trap design as well as simulations of the resulting trapping pseudo-potential. We also present a compact, multi-channel wavelength meter that will permit the frequency stabilization of the cooling, repumping and clear-out lasers at 369.5 nm, 935.2 nm and 638.6 nm needed to cool the ion. We use this wavelength meter to characterize and stabilize the frequency of extended cavity diode lasers at 369.5 nm and 638.6 nm.

  19. Quantum theory of atomic clocks and gravito-inertial sensors: an update

    Energy Technology Data Exchange (ETDEWEB)

    Antoine, Ch [Equipe de Relativite Gravitation et Astrophysique, LERMA, UMR 8112, CNRS-Observatoire de Paris, Universite Pierre et Marie Curie, 4 place Jussieu, 75005 Paris (France); Borde, Ch J [Equipe de Relativite Gravitation et Astrophysique, LERMA, UMR 8112, CNRS-Observatoire de Paris, Universite Pierre et Marie Curie, 4 place Jussieu, 75005 Paris (France)

    2003-04-01

    In the framework of the ABCD{xi} formulation of atom optics and with an adequate modelization of the beam splitters, we establish an exact analytical phase shift expression for atom interferometers. This result is valid for a time-dependent external Hamiltonian at most quadratic in position and momentum operators and is expressed in terms of coordinates and momenta of the wave packet centres at the interaction vertices only. As a specific application, the case of atom gyrometers and accelerometers is presented in detail.

  20. Simple-design ultra-low phase noise microwave frequency synthesizers for high-performing Cs and Rb vapor-cell atomic clocks

    International Nuclear Information System (INIS)

    We report on the development and characterization of novel 4.596 GHz and 6.834 GHz microwave frequency synthesizers devoted to be used as local oscillators in high-performance Cs and Rb vapor-cell atomic clocks. The key element of the synthesizers is a custom module that integrates a high spectral purity 100 MHz oven controlled quartz crystal oscillator frequency-multiplied to 1.6 GHz with minor excess noise. Frequency multiplication, division, and mixing stages are then implemented to generate the exact output atomic resonance frequencies. Absolute phase noise performances of the output 4.596 GHz signal are measured to be −109 and −141 dB rad2/Hz at 100 Hz and 10 kHz Fourier frequencies, respectively. The phase noise of the 6.834 GHz signal is −105 and −138 dB rad2/Hz at 100 Hz and 10 kHz offset frequencies, respectively. The performances of the synthesis chains contribute to the atomic clock short term fractional frequency stability at a level of 3.1 × 10−14 for the Cs cell clock and 2 × 10−14 for the Rb clock at 1 s averaging time. This value is comparable with the clock shot noise limit. We describe the residual phase noise measurements of key components and stages to identify the main limitations of the synthesis chains. The residual frequency stability of synthesis chains is measured to be at the 10−15 level for 1 s integration time. Relevant advantages of the synthesis design, using only commercially available components, are to combine excellent phase noise performances, simple-architecture, low-cost, and to be easily customized for signal output generation at 4.596 GHz or 6.834 GHz for applications to Cs or Rb vapor-cell frequency standards

  1. Simple-design ultra-low phase noise microwave frequency synthesizers for high-performing Cs and Rb vapor-cell atomic clocks

    Energy Technology Data Exchange (ETDEWEB)

    François, B. [FEMTO-ST, CNRS, Université de Franche-Comté, 26 chemin de l’Epitaphe, 25030 Besançon (France); INRIM, Strada delle Cacce 91, 10135 Torino (Italy); Calosso, C. E.; Micalizio, S. [INRIM, Strada delle Cacce 91, 10135 Torino (Italy); Abdel Hafiz, M.; Boudot, R. [FEMTO-ST, CNRS, Université de Franche-Comté, 26 chemin de l’Epitaphe, 25030 Besançon (France)

    2015-09-15

    We report on the development and characterization of novel 4.596 GHz and 6.834 GHz microwave frequency synthesizers devoted to be used as local oscillators in high-performance Cs and Rb vapor-cell atomic clocks. The key element of the synthesizers is a custom module that integrates a high spectral purity 100 MHz oven controlled quartz crystal oscillator frequency-multiplied to 1.6 GHz with minor excess noise. Frequency multiplication, division, and mixing stages are then implemented to generate the exact output atomic resonance frequencies. Absolute phase noise performances of the output 4.596 GHz signal are measured to be −109 and −141 dB rad{sup 2}/Hz at 100 Hz and 10 kHz Fourier frequencies, respectively. The phase noise of the 6.834 GHz signal is −105 and −138 dB rad{sup 2}/Hz at 100 Hz and 10 kHz offset frequencies, respectively. The performances of the synthesis chains contribute to the atomic clock short term fractional frequency stability at a level of 3.1 × 10{sup −14} for the Cs cell clock and 2 × 10{sup −14} for the Rb clock at 1 s averaging time. This value is comparable with the clock shot noise limit. We describe the residual phase noise measurements of key components and stages to identify the main limitations of the synthesis chains. The residual frequency stability of synthesis chains is measured to be at the 10{sup −15} level for 1 s integration time. Relevant advantages of the synthesis design, using only commercially available components, are to combine excellent phase noise performances, simple-architecture, low-cost, and to be easily customized for signal output generation at 4.596 GHz or 6.834 GHz for applications to Cs or Rb vapor-cell frequency standards.

  2. Imaging Microwave and DC Magnetic Fields in a Vapor-Cell Rb Atomic Clock

    CERN Document Server

    Affolderbach, Christoph; Bandi, Thejesh; Horsley, Andrew; Treutlein, Philipp; Mileti, Gaetano

    2015-01-01

    We report on the experimental measurement of the DC and microwave magnetic field distributions inside a recently-developed compact magnetron-type microwave cavity, mounted inside the physics package of a high-performance vapor-cell atomic frequency standard. Images of the microwave field distribution with sub-100 $\\mu$m lateral spatial resolution are obtained by pulsed optical-microwave Rabi measurements, using the Rb atoms inside the cell as field probes and detecting with a CCD camera. Asymmetries observed in the microwave field images can be attributed to the precise practical realization of the cavity and the Rb vapor cell. Similar spatially-resolved images of the DC magnetic field distribution are obtained by Ramsey-type measurements. The T2 relaxation time in the Rb vapor cell is found to be position dependent, and correlates with the gradient of the DC magnetic field. The presented method is highly useful for experimental in-situ characterization of DC magnetic fields and resonant microwave structures,...

  3. Limits on the temporal variation of the fine structure constant, quark masses and strong interaction from quasar absorption spectra and atomic clock experiments

    CERN Document Server

    Flambaum, V V; Thomas, A W; Young, R D

    2004-01-01

    We perform calculations of the dependence of nuclear magnetic moments on quark masses and obtain limits on the variation of $(m_q/\\Lambda_{QCD})$ from recent measurements of hydrogen hyperfine (21 cm) and molecular rotational transitions in quasar absorption systems, atomic clock experiments with hyperfine transitions in H, Rb, Cs, Yb$^+$, Hg$^+$ and optical transition in Hg$^+$. Experiments with Cd$^+$, deuterium/hydrogen, molecular SF$_6$ and Zeeman transitions in $^3$He/Xe are also discussed.

  4. 星载原子钟数据预处理的方法研究%Research on the Methods of Preprocessing the Satellite-Borne Atomic Clocks Data

    Institute of Scientific and Technical Information of China (English)

    李斌; 杨富春; 江峻毅

    2015-01-01

    Satellite-borne atomic clocks data preprocessing is the basis of atomic clocks performance analysis and clock forecasting,phase and frequency of data conversion and abnormal data analysis and processing methods are used to preprocess the clocks data, these methods can effectively guarantee the re-liability of the clocks data.%星载原子钟的数据预处理是进行原子钟性能分析和钟差预报的前提,本文主要利用相位数据和频率数据的转换和异常数据的分析处理方法对原子钟数据进行了预处理,有效的保证了数据的可靠性。

  5. Phase Coherent Link of an Atomic Clock to a Self-Referenced Microresonator Frequency Comb

    CERN Document Server

    Del'Haye, Pascal; Fortier, Tara; Beha, Katja; Cole, Daniel C; Yang, Ki Youl; Lee, Hansuek; Vahala, Kerry J; Papp, Scott B; Diddams, Scott A

    2015-01-01

    The counting and control of optical cycles of light has become common with modelocked laser frequency combs. But even with advances in laser technology, modelocked laser combs remain bulk-component devices that are hand-assembled. In contrast, a frequency comb based on the Kerr-nonlinearity in a dielectric microresonator will enable frequency comb functionality in a micro-fabricated and chip-integrated package suitable for use in a wide-range of environments. Such an advance will significantly impact fields ranging from spectroscopy and trace gas sensing, to astronomy, communications, atomic time keeping and photonic data processing. Yet in spite of the remarkable progress shown over the past years, microresonator frequency combs ("microcombs") have still been without the key function of direct f-2f self-referencing and phase-coherent frequency control that will be critical for enabling their full potential. Here we realize these missing elements using a low-noise 16.4 GHz silicon chip microcomb that is coher...

  6. A HBAR-oscillator-based 4.596~GHz frequency source: Application to a coherent population trapping Cs vapor cell atomic clock

    CERN Document Server

    Daugey, Thomas; Martin, Gilles; Boudot, Rodolphe

    2015-01-01

    This article reports on the design and characterization of a high-overtone bulk acoustic wave resonator (HBAR)-oscillator-based 4.596~GHz frequency source. A 2.298~GHz signal, generated by an oscillator constructed around a thermally-controlled two-port AlN-sapphire HBAR resonator with a Q-factor of 24000 at 68$^{\\circ}$C, is frequency multiplied by 2 to 4.596~GHz, half of the Cs atom clock frequency. The temperature coefficient of frequency (TCF) of the HBAR is measured to be $-23$~ppm/$^{\\circ}$C at 2.298~GHz. The measured phase noise of the 4.596~GHz source is $-105$~dBrad$^2$/Hz at 1~kHz offset and $-150$~dBrad$^2$/Hz at 100~kHz offset. The 4.596~GHz output signal is used as a local oscillator (LO) in a laboratory-prototype Cs microcell-based coherent population trapping (CPT) atomic clock. The signal is stabilized onto the atomic transition frequency by tuning finely a voltage-controlled phase shifter (VCPS) implemented in the 2.298~GHz HBAR-oscillator loop, preventing the need for a high-power-consuming...

  7. Stability Analysis of the In-Orbit Satellite Atomic Clocks%GPS在轨卫星原子钟的稳定性分析

    Institute of Scientific and Technical Information of China (English)

    李长会; 闫国锋

    2012-01-01

    导航卫星星载原子钟的相位或频率数据,作为导航系统应用研究的基础,将直接影响导航系统时间尺度建立以及定位的精度和准确性.本文针对由IGS官网提供的四种GPS卫星钟的钟差数据,采用修正阿伦方差进行了稳定性分析,得到了一些有益的结论.%As the application research basis of navigation system, the phase or frequency data of in - orbit satellite atomic clocks directly affect the precision and accuracy of navigation system. This paper analyzes the stability of four types of data of GPS satellite a-tomic clocks which is provided by the official website of IGS using Allan variance method and reaches some beneficial conclusions.

  8. A high-overtone bulk acoustic wave resonator-oscillator-based 4.596 GHz frequency source: Application to a coherent population trapping Cs vapor cell atomic clock

    Energy Technology Data Exchange (ETDEWEB)

    Daugey, Thomas; Friedt, Jean-Michel; Martin, Gilles; Boudot, Rodolphe [FEMTO-ST, CNRS, UFC, 26 chemin de l’Epitaphe 25030 Besançon Cedex (France)

    2015-11-15

    This article reports on the design and characterization of a high-overtone bulk acoustic wave resonator (HBAR)-oscillator-based 4.596 GHz frequency source. A 2.298 GHz signal, generated by an oscillator constructed around a thermally controlled two-port aluminum nitride-sapphire HBAR resonator with a Q-factor of 24 000 at 68 °C, is frequency multiplied by 2–4.596 GHz, half of the Cs atom clock frequency. The temperature coefficient of frequency of the HBAR is measured to be −23 ppm/ °C at 2.298 GHz. The measured phase noise of the 4.596 GHz source is −105 dB rad{sup 2}/Hz at 1 kHz offset and −150 dB rad{sup 2}/Hz at 100 kHz offset. The 4.596 GHz output signal is used as a local oscillator in a laboratory-prototype Cs microcell-based coherent population trapping atomic clock. The signal is stabilized onto the atomic transition frequency by tuning finely a voltage-controlled phase shifter implemented in the 2.298 GHz HBAR-oscillator loop, preventing the need for a high-power-consuming direct digital synthesis. The short-term fractional frequency stability of the free-running oscillator is 1.8 × 10{sup −9} at one second integration time. In locked regime, the latter is improved in a preliminary proof-of-concept experiment at the level of 6.6 × 10{sup −11} τ{sup −1/2} up to a few seconds and found to be limited by the signal-to-noise ratio of the detected CPT resonance.

  9. A high-overtone bulk acoustic wave resonator-oscillator-based 4.596 GHz frequency source: Application to a coherent population trapping Cs vapor cell atomic clock

    International Nuclear Information System (INIS)

    This article reports on the design and characterization of a high-overtone bulk acoustic wave resonator (HBAR)-oscillator-based 4.596 GHz frequency source. A 2.298 GHz signal, generated by an oscillator constructed around a thermally controlled two-port aluminum nitride-sapphire HBAR resonator with a Q-factor of 24 000 at 68 °C, is frequency multiplied by 2–4.596 GHz, half of the Cs atom clock frequency. The temperature coefficient of frequency of the HBAR is measured to be −23 ppm/ °C at 2.298 GHz. The measured phase noise of the 4.596 GHz source is −105 dB rad2/Hz at 1 kHz offset and −150 dB rad2/Hz at 100 kHz offset. The 4.596 GHz output signal is used as a local oscillator in a laboratory-prototype Cs microcell-based coherent population trapping atomic clock. The signal is stabilized onto the atomic transition frequency by tuning finely a voltage-controlled phase shifter implemented in the 2.298 GHz HBAR-oscillator loop, preventing the need for a high-power-consuming direct digital synthesis. The short-term fractional frequency stability of the free-running oscillator is 1.8 × 10−9 at one second integration time. In locked regime, the latter is improved in a preliminary proof-of-concept experiment at the level of 6.6 × 10−11 τ−1/2 up to a few seconds and found to be limited by the signal-to-noise ratio of the detected CPT resonance

  10. A high-overtone bulk acoustic wave resonator-oscillator-based 4.596 GHz frequency source: Application to a coherent population trapping Cs vapor cell atomic clock.

    Science.gov (United States)

    Daugey, Thomas; Friedt, Jean-Michel; Martin, Gilles; Boudot, Rodolphe

    2015-11-01

    This article reports on the design and characterization of a high-overtone bulk acoustic wave resonator (HBAR)-oscillator-based 4.596 GHz frequency source. A 2.298 GHz signal, generated by an oscillator constructed around a thermally controlled two-port aluminum nitride-sapphire HBAR resonator with a Q-factor of 24,000 at 68 °C, is frequency multiplied by 2-4.596 GHz, half of the Cs atom clock frequency. The temperature coefficient of frequency of the HBAR is measured to be -23 ppm/ °C at 2.298 GHz. The measured phase noise of the 4.596 GHz source is -105 dB rad(2)/Hz at 1 kHz offset and -150 dB rad(2)/Hz at 100 kHz offset. The 4.596 GHz output signal is used as a local oscillator in a laboratory-prototype Cs microcell-based coherent population trapping atomic clock. The signal is stabilized onto the atomic transition frequency by tuning finely a voltage-controlled phase shifter implemented in the 2.298 GHz HBAR-oscillator loop, preventing the need for a high-power-consuming direct digital synthesis. The short-term fractional frequency stability of the free-running oscillator is 1.8 × 10(-9) at one second integration time. In locked regime, the latter is improved in a preliminary proof-of-concept experiment at the level of 6.6 × 10(-11) τ(-1/2) up to a few seconds and found to be limited by the signal-to-noise ratio of the detected CPT resonance.

  11. ac Stark shift measurements of the clock transition in cold Cs atoms: Scalar and tensor light shifts of the D2 transition

    Science.gov (United States)

    Costanzo, G. A.; Micalizio, S.; Godone, A.; Camparo, J. C.; Levi, F.

    2016-06-01

    The ac Stark shift, or light shift, is a physical phenomenon that plays a fundamental role in many applications ranging from basic atomic physics to applied quantum electronics. Here, we discuss experiments testing light-shift theory in a cold-atom cesium fountain clock for the Cs D2 transition (i.e., 6 2S1 /2→6 2P3 /2 at 852 nm). Cold-atom fountains represent a nearly ideal system for the study of light shifts: (1) The atoms can be perturbed by a field of arbitrary character (e.g., coherent field or nonclassical field); (2) there are no trapping fields to complicate data interpretation; (3) the probed atoms are essentially motionless in their center-of-mass reference frame, T ˜ 1 μK; and (4) the atoms are in an essentially collisionless environment. Moreover, in the present work the resolution of the Cs excited-state hyperfine splittings implies that the D2 ac Stark shift contains a nonzero tensor polarizability contribution, which does not appear in vapor phase experiments due to Doppler broadening. Here, we test the linearity of the ac Stark shift with field intensity, and measure the light shift as a function of field frequency, generating a "light-shift curve." We have improved on the previous best test of theory by a factor of 2, and after subtracting the theoretical scalar light shift from the experimental light-shift curves, we have isolated and tested the tensor light shift for an alkali D2 transition.

  12. Progress of the ~(87)Rb Fountain Clock

    Institute of Scientific and Technical Information of China (English)

    ZHOU Zi-Chao; WEI Rong; SHI Chun-Yan; LV De-Sheng; LI Tang; WANG Yu-Zhu

    2009-01-01

    A fountain atomic clock based on cold ~(87)Rb atoms has been in operation in our laboratory for several months.We therefore report the design of the rubidium fountain clock including its physical package,optical system and daily operation.Ramsey fringes have been attained with the signal to noise ratio of about 100.

  13. Self-generating magnetometer with laser pumping employment in “end resonance” wall coated vapor cell atomic clocks

    Science.gov (United States)

    Baranov, A. A.; Ermak, S. V.; Smolin, R. V.; Semenov, V. V.

    2016-06-01

    This paper presents the results of two double resonance signals correlation investigation. These signals were observed synchronously in optically oriented Rb87 vapors with laser pumping in a dual scheme: low frequency Mx-magnetometer and microwave frequency discriminator. Analytical studies of the scalar and vector light shift components contribution to the frequency instability of the end resonance microwave transitions are presented. An experimental demonstration of the light shift components mutual compensation in optically pumped Rb87 atoms was provided. The results were processed in terms of Allan variance, which demonstrated an effect of decreasing frequency variation at averaging times more than 100 s for a joint scheme of the end resonance microwave transition and selfgenerating (Mx) magnetometer.

  14. 欧洲空间原子钟组ACES 与超高精度时频传递技术新进展%Advances in Atomic Clock Ensemble in Space of Europe and Ultraprecise Time and Frequency Transfer

    Institute of Scientific and Technical Information of China (English)

    杨文可; 孟文东; 韩文标; 谢勇辉; 任晓乾; 胡小工; 董文丽

    2016-01-01

    高精度时间频率的产生和超高精度时频信号的传递是现代物理学、天文学和计量科学的基础。空间原子钟组计划(Atomic Clock Ensemble in Space, ACES)是由欧洲空间局实施的基于国际空间站(International Space Station, ISS)微重力环境下的新型空间微波原子钟实验验证项目。概要介绍ACES项目基本情况,重点介绍ACES项目的主要科学和技术目标,围绕科学目标而形成的ACES 组成结构,并梳理涉及的关键技术,特别介绍了ACES 将应用的超高精度时频传递技术,为我国自主研究并实现相关空间时间频率系统及其应用提供参考。最后简述了我国正在建设的空间站时频系统主要情况和实施计划。%One of the foundations for the development of modern physics, astronomy and metrology is the generation, transfer and measurement of high precision time frequency signals. As a space mission for the study of high precision time frequency signals, Atomic Clock Ensemble in Space, or ACES, sponsored by European Space Agency to launch in 2017 or later, will take advantage of the excellent stability performance of microwave atomic clocks in a microgravity environment. One clock using laser-cooled Cs atoms working together with one hydrogen maser clock are planned to be placed onboard the International Space Station in hope to produce a frequency standard with both accuracy and stability reaching the level of 10−16. A microwave link along with a laser link will be set up between ACES and ground atomic clocks distributed around the world for high precision comparison and transfer. Various basic researches will benefit from a high precision space atomic clock such as the verification of Einstein’s general relativity, detection of possible time variability of certain fundamental constants in physics, as well as brand new applications such as relativistic gravity and GNSS remote sensing. This paper reviews and summarizes the

  15. Body Clock

    Institute of Scientific and Technical Information of China (English)

    刘洪毓

    2000-01-01

    “Body clocks” are biological methods of controling body activities.Every living thing has one. In humans, a body clock controls normal periods of sleeping and waking. It controls the time swhen you are most likely to feel pain.Eating, sleeping and exercising at about the same time each day will help keep body activities normal. But changes in your life, a new job, for example, destroy the balance and thus cause health problems.

  16. First observation of the strongly forbidden transition {sup 1}S{sub 0} - {sup 3}P{sub 0} in Strontium, for an atomic clock with trapped atoms; Premiere observation de la transition fortement interdite {sup 1}S{sub 0} - {sup 3}P{sub 0} du strontium, pour une horloge optique a atomes pieges

    Energy Technology Data Exchange (ETDEWEB)

    Courtillot, I

    2003-11-01

    This thesis reports the first results towards the realization of an optical clock using trapped strontium atoms. This set up would combine advantages of the different approaches commonly used to develop an atomic frequency standard. The first part describes the cold atoms source which is implemented. A magneto-optical trap operating on the {sup 1}S{sub 0}-{sup 1}P{sub 1} transition at 461 nm is loaded from an atomic beam decelerated by a Zeeman slower. The 461 nm laser is obtained by sum-frequency mixing in a potassium titanyl phosphate (KTP) crystal. The second part is devoted to the different stages developed to achieve the direct excitation of the {sup 1}S{sub 0}-{sup 3}P{sub 0} clock transition in {sup 87}Sr. This line has a theoretical natural width of 10{sup -3} Hz. Before this detection, we obtained an estimate of the resonance frequency by measuring absolute frequencies of several allowed optical transitions. (author)

  17. Performances evaluation of the PHARAO atomic fountain: participation to the study of the PHARAO space clock; Evaluation des performances de la fontaine atomique PHARAO, participation a l'etude de l'horloge spatiale PHARAO

    Energy Technology Data Exchange (ETDEWEB)

    Abgrall, M

    2003-01-01

    The performances of an atomic frequency standard depend drastically on the observation time of the atoms. The interrogation of laser cooled atoms allows to obtain about half a second interaction time in a fountain geometry. This duration could be much more varied in absence of gravity, and would allow a better trade-off between stability and accuracy. The application of this principle is the aim of the PHARAO project, that should attend to the ACES mission planned in 2006 onboard the International Space Station. The first part of this thesis deals with the cold Cs{sup 133} PHARAO fountain. This clock stems from the transformation of a space clock prototype previously tested in microgravity. A detailed evaluation of the whole frequency shifts has been carried out, reaching a 7.7 10{sup -16} accuracy and a 1.7 10{sup -13}{tau}{sup -1/2} short term stability. These values are obtained for 4 10{sup 5} detected atoms, that provides a good stability-accuracy trade-off. This transportable fountain, built at BNM-SYRTE, has been operating at MPQ in Munich (Germany). The collaboration between the 2 laboratories gave a {approx} 10 improvement factor on the measurement accuracy (1.8 10{sup -14}) for the 1S - 2S two photons hydrogen transition. In a second part of this thesis, we present the characterisation of 2 elements of the PHARAO space clock: the construction of a standard extended cavity laser and the test of the phase symmetry between the two interrogating areas of the space cavity. (author)

  18. Synthetic Spin-Orbit Coupling in an Optical Lattice Clock

    Science.gov (United States)

    Wall, Michael L.; Koller, Andrew P.; Li, Shuming; Zhang, Xibo; Cooper, Nigel R.; Ye, Jun; Rey, Ana Maria

    2016-01-01

    We propose the use of optical lattice clocks operated with fermionic alkaline-earth atoms to study spin-orbit coupling (SOC) in interacting many-body systems. The SOC emerges naturally during the clock interrogation, when atoms are allowed to tunnel and accumulate a phase set by the ratio of the "magic" lattice wavelength to the clock transition wavelength. We demonstrate how standard protocols such as Rabi and Ramsey spectroscopy that take advantage of the sub-Hertz resolution of state-of-the-art clock lasers can perform momentum-resolved band tomography and determine SOC-induced s -wave collisions in nuclear-spin-polarized fermions. With the use of a second counterpropagating clock beam, we propose a method for engineering controlled atomic transport and study how it is modified by p - and s -wave interactions. The proposed spectroscopic probes provide clean and well-resolved signatures at current clock operating temperatures.

  19. S-Wave Collisional Frequency Shift of a Fermion Clock

    CERN Document Server

    Hazlett, Eric L; Stites, Ronald W; Gibble, Kurt; O'Hara, Kenneth M

    2012-01-01

    We report an s-wave collisional frequency shift of an atomic clock based on fermions. In contrast to bosons, the fermion clock shift is insensitive to the population difference of the clock states, set by the first pulse area in Ramsey spectroscopy, \\theta_1. The fermion shift instead depends strongly on the second pulse area \\theta_2. It allows the shift to be canceled, nominally at \\theta_2 = \\pi/2, but correlations shift the null to slightly larger \\theta_2. The shift applies to optical lattice clocks and increases with the spatial inhomogeneity of the clock excitation field, naturally large at optical frequencies.

  20. Internal Clock Drift Estimation in Computer Clusters

    Directory of Open Access Journals (Sweden)

    Hicham Marouani

    2008-01-01

    Full Text Available Most computers have several high-resolution timing sources, from the programmable interrupt timer to the cycle counter. Yet, even at a precision of one cycle in ten millions, clocks may drift significantly in a single second at a clock frequency of several GHz. When tracing the low-level system events in computer clusters, such as packet sending or reception, each computer system records its own events using an internal clock. In order to properly understand the global system behavior and performance, as reported by the events recorded on each computer, it is important to estimate precisely the clock differences and drift between the different computers in the system. This article studies the clock precision and stability of several computer systems, with different architectures. It also studies the typical network delay characteristics, since time synchronization algorithms rely on the exchange of network packets and are dependent on the symmetry of the delays. A very precise clock, based on the atomic time provided by the GPS satellite network, was used as a reference to measure clock drifts and network delays. The results obtained are of immediate use to all applications which depend on computer clocks or network time synchronization accuracy.

  1. Atomic Properties of Lu$^+$

    OpenAIRE

    Paez, Eduardo; Arnold, K. J.; Hajiyev, Elnur; Porsev, S. G.; Dzuba, V. A.; Safronova, U. I.; Safronova, M.S.; Barrett, M. D.

    2016-01-01

    Singly ionised Lutetium has recently been suggested as a potential clock candidate. Here we report a joint experimental and theoretical investigation of \\ce{Lu^+}. Measurements relevant to practical clock operation are made and compared to atomic structure calculations. Calculations of scalar and tensor polarizabilities for clock states over a range of wavelengths are also given. These results will be useful for future work with this clock candidate.

  2. Atomic properties of Lu+

    Science.gov (United States)

    Paez, Eduardo; Arnold, K. J.; Hajiyev, Elnur; Porsev, S. G.; Dzuba, V. A.; Safronova, U. I.; Safronova, M. S.; Barrett, M. D.

    2016-04-01

    Singly ionized lutetium has recently been suggested as a potential clock candidate. Here we report a joint experimental and theoretical investigation of Lu+. Measurements relevant to practical clock operation are made and compared to atomic structure calculations. Calculations of scalar and tensor polarizabilities for clock states over a range of wavelengths are also given. These results will be useful for future work with this clock candidate.

  3. Lego clocks : building a clock from parts

    NARCIS (Netherlands)

    Brunner, Michael; Simons, Mirre J. P.; Merrow, Martha

    2008-01-01

    A new finding opens up speculation that the molecular mechanism of circadian clocks in Synechococcus elongatus is composed of multiple oscillator systems (Kitayama and colleagues, this issue, pp. 1513-1521), as has been described in many eukaryotic clock model systems. However, an alternative intepr

  4. Optical Clocks in Space

    CERN Document Server

    Schiller, S; Nevsky, A; Koelemeij, J C J; Wicht, A; Gill, P; Klein, H A; Margolis, H S; Mileti, G; Sterr, U; Riehle, F; Peik, E; Tamm, C; Ertmer, W; Rasel, E; Klein, V; Salomon, C; Tino, G M; Lemonde, P; Holzwarth, R; Hänsch, T W; Tamm, Chr.

    2007-01-01

    The performance of optical clocks has strongly progressed in recent years, and accuracies and instabilities of 1 part in 10^18 are expected in the near future. The operation of optical clocks in space provides new scientific and technological opportunities. In particular, an earth-orbiting satellite containing an ensemble of optical clocks would allow a precision measurement of the gravitational redshift, navigation with improved precision, mapping of the earth's gravitational potential by relativistic geodesy, and comparisons between ground clocks.

  5. Recent progress of neutral mercury lattice clock in SIOM

    Science.gov (United States)

    Zhao, R. C.; Fu, X. H.; Liu, K. K.; Gou, W.; Sun, J. F.; Xu, Z.; Wang, Y. Z.

    2016-06-01

    Neutral mercury atom is one of good candidates of optical lattice clock. Due to its large atomic number, mercury atom is insensitive to black body radiation, which is the severe limitation for the development of optical clocks. However, the challenge of neutral mercury lattice clock is the requirement of high power deep-UV lasers, especially for both the cooling laser and the lattice laser. Here, we report the recent progress of neutral mercury lattice clock in SIOM, including the development for laser cooling of mercury atom and the cooling laser system with fiber laser amplifier. We have realized the magneto-optical trap of mercury atoms and measured the parameters of cold mercury atoms. A home-made external cavity diode laser works as a seed laser for a room temperature 1014.8 nm fiber laser amplifier. A new efficient frequency-doubling cavity from 1015 nm to 507 nm has been developed.

  6. Frequency comparison of optical lattice clocks beyond the Dick limit

    Science.gov (United States)

    Takamoto, Masao; Takano, Tetsushi; Katori, Hidetoshi

    2011-05-01

    The supreme accuracy of atomic clocks relies on the universality of atomic transition frequencies. The stability of a clock, meanwhile, measures how quickly the clock's statistical uncertainties are reduced. The ultimate measure of stability is provided by the quantum projection noise, which improves as 1/√N by measuring N uncorrelated atoms. Quantum projection noise limited stabilities have been demonstrated in caesium clocks and in single-ion optical clocks, where the quantum noise overwhelms the Dick effect attributed to local oscillator noise. Here, we demonstrate a synchronous frequency comparison of two optical lattice clocks using 87Sr and 88Sr atoms, respectively, for which the Allan standard deviation reached 1 × 10-17 in an averaging time of 1,600 s by cancelling out the Dick effect to approach the quantum projection noise limit. The scheme demonstrates the advantage of using a large number (N ~ 1,000) of atoms in optical clocks and paves the way to investigating the inherent uncertainties of clocks and relativistic geodesy on a timescale of tens of minutes.

  7. Atoms

    Institute of Scientific and Technical Information of China (English)

    刘洪毓

    2007-01-01

    Atoms(原子)are all around us.They are something like the bricks (砖块)of which everything is made. The size of an atom is very,very small.In just one grain of salt are held millions of atoms. Atoms are very important.The way one object acts depends on what

  8. Hanle detection for optical clocks.

    Science.gov (United States)

    Zhang, Xiaogang; Zhang, Shengnan; Pan, Duo; Chen, Peipei; Xue, Xiaobo; Zhuang, Wei; Chen, Jingbiao

    2015-01-01

    Considering the strong inhomogeneous spatial polarization and intensity distribution of spontaneous decay fluorescence due to the Hanle effect, we propose and demonstrate a universe Hanle detection configuration of electron-shelving method for optical clocks. Experimental results from Ca atomic beam optical frequency standard with electron-shelving method show that a designed Hanle detection geometry with optimized magnetic field direction, detection laser beam propagation and polarization direction, and detector position can improve the fluorescence collection rate by more than one order of magnitude comparing with that of inefficient geometry. With the fixed 423 nm fluorescence, the improved 657 nm optical frequency standard signal intensity is presented. The potential application of the Hanle detection geometry designed for facilitating the fluorescence collection for optical lattice clock with a limited solid angle of the fluorescence collection has been discussed. The Hanle detection geometry is also effective for ion detection in ion optical clock and quantum information experiments. Besides, a cylinder fluorescence collection structure is designed to increase the solid angle of the fluorescence collection in Ca atomic beam optical frequency standard. PMID:25734183

  9. Hanle Detection for Optical Clocks

    Directory of Open Access Journals (Sweden)

    Xiaogang Zhang

    2015-01-01

    Full Text Available Considering the strong inhomogeneous spatial polarization and intensity distribution of spontaneous decay fluorescence due to the Hanle effect, we propose and demonstrate a universe Hanle detection configuration of electron-shelving method for optical clocks. Experimental results from Ca atomic beam optical frequency standard with electron-shelving method show that a designed Hanle detection geometry with optimized magnetic field direction, detection laser beam propagation and polarization direction, and detector position can improve the fluorescence collection rate by more than one order of magnitude comparing with that of inefficient geometry. With the fixed 423 nm fluorescence, the improved 657 nm optical frequency standard signal intensity is presented. The potential application of the Hanle detection geometry designed for facilitating the fluorescence collection for optical lattice clock with a limited solid angle of the fluorescence collection has been discussed. The Hanle detection geometry is also effective for ion detection in ion optical clock and quantum information experiments. Besides, a cylinder fluorescence collection structure is designed to increase the solid angle of the fluorescence collection in Ca atomic beam optical frequency standard.

  10. Superradiance on the milliHertz linewidth strontium clock transition

    CERN Document Server

    Norcia, Matthew A; Cline, Julia R K; Thompson, James K

    2016-01-01

    Today's best atomic clocks are limited by frequency noise on the lasers used to interrogate the atoms. A proposed solution to this problem is to create a superradiant laser using an optical clock transition as its gain medium. This laser would act as an active atomic clock, and would be highly immune to the fluctuations in reference cavity length that limit today's best lasers. Here, we demonstrate and characterize superradiant emission from the mHz linewidth clock transition in an ensemble of laser-cooled $^{87}$Sr atoms trapped within a high-finesse optical cavity. We measure a collective enhancement of the emission rate into the cavity mode by a factor of more than 10,000 compared to independently radiating atoms. We also demonstrate a method for seeding superradiant emission and observe interference between two independent transitions lasing simultaneously. We use this interference to characterize the relative spectral properties of the two lasing sub-ensembles.

  11. Hanle detection for optical clocks

    CERN Document Server

    Zhang, Xiaogang; Pan, Duo; Chen, Peipei; Xue, Xiaobo; Zhuang, Wei; Chen, Jingbiao

    2014-01-01

    Considering the strong inhomogeneous spatial polarization and intensity distribution of spontaneous decay fluorescence due to the Hanle effect, we propose and demonstrate a universe Hanle detection configuration of electron-shelving method for optical clocks. Experimental results from Ca atomic beam optical frequency standard with 423 nm electron-shelving method show that a designed Hanle detection geometry with optimized magnetic field direction, detection laser beam propagation and polarization direction, and detector position can improve the fluorescence collection rate by more than one order of magnitude comparing with that of inefficient geometry. With the fixed 423 nm fluorescence, the improved 657 nm optical frequency standard signal intensity is presented. And the potential application of the Hanle detection geometry designed for facilitating the fluorescence collection for optical lattice clock with a limited solid angle of the fluorescence collection has been discussed. This Hanle detection configur...

  12. Realization of a time-scale with an optical clock

    CERN Document Server

    Grebing, C; Dörscher, S; Häfner, S; Gerginov, V; Weyers, S; Lipphardt, B; Riehle, F; Sterr, U; Lisdat, C

    2015-01-01

    Optical clocks are not only powerful tools for prime fundamental research, but are also deemed for the re-definition of the SI base unit second as they surpass the performance of caesium atomic clocks in both accuracy and stability by more than an order of magnitude. However, an important obstacle in this transition has so far been the limited reliability of the optical clocks that made a continuous realization of a time-scale impractical. In this paper, we demonstrate how this dilemma can be resolved and that a time-scale based on an optical clock can be established that is superior to one based on even the best caesium fountain clocks. The paper also gives further proof of the international consistency of strontium lattice clocks on the $10^{-16}$ accuracy level, which is another prerequisite for a change in the definition of the second.

  13. Toward A Neutral Mercury Optical Lattice Clock: Determination of the Magic Wavelength for the Ultraviolet clock Transition

    International Nuclear Information System (INIS)

    A lattice clock combines the advantages of ion and neutral atom based clocks, namely the recoil and first order Doppler free spectroscopy allowed by the Lamb-Dicke regime. This lattice light field shifts the energy levels of the clock transition. However a wavelength can be found where the light-shift of the clock states cancelled to first order. In this thesis, we present the latest advances in optical lattice clock with mercury atoms developed at LNE-SYRTE. After a review of the current performances of different optical clock are currently under development, we focus on the concept of optical lattice clock and the features of the mercury that make him an excellent candidate for the realization of an optical lattice clock achievement the uncertainty of the level of 10-17. The second part is devoted to the characterization of the mercury MOT, using a sensitive detection system, which allowed us to evaluate the temperature of different isotopes present in the MOT and have a good evidence of sub-Doppler cooling for the fermionic isotopes. The third part of this these, present the experimental aspects of the implementation and the development of the laser source required for trapping mercury atoms operating near the predicted magic wavelength. Finally, we report on the Lamb-Dicke spectroscopy of the 1S0 →3 P0 clock transition in the 199Hg atoms confined in lattice trap. With use of the ultra-stable laser system, linked to LNE-SYRTE primary frequency reference, we have determined the center frequency of the transition for a range of lattice wavelengths and different lattice depths. Analyzing these measurement, we have carried out the first experimental determination of the magic wavelength, which is the crucial step towards achieving a highly accurate frequency standard using mercury. (author)

  14. A self-interfering clock as a "which path" witness.

    Science.gov (United States)

    Margalit, Yair; Zhou, Zhifan; Machluf, Shimon; Rohrlich, Daniel; Japha, Yonathan; Folman, Ron

    2015-09-11

    In Einstein's general theory of relativity, time depends locally on gravity; in standard quantum theory, time is global-all clocks "tick" uniformly. We demonstrate a new tool for investigating time in the overlap of these two theories: a self-interfering clock, comprising two atomic spin states. We prepare the clock in a spatial superposition of quantum wave packets, which evolve coherently along two paths into a stable interference pattern. If we make the clock wave packets "tick" at different rates, to simulate a gravitational time lag, the clock time along each path yields "which path" information, degrading the pattern's visibility. In contrast, in standard interferometry, time cannot yield "which path" information. This proof-of-principle experiment may have implications for the study of time and general relativity and their impact on fundamental effects such as decoherence and the emergence of a classical world. PMID:26249229

  15. Clocking in the face of unpredictability beyond quantum uncertainty

    Science.gov (United States)

    Madjid, F. Hadi; Myers, John M.

    2015-05-01

    In earlier papers we showed unpredictability beyond quantum uncertainty in atomic clocks, ensuing from a proven gap between given evidence and explanations of that evidence. Here we reconceive a clock, not as an isolated entity, but as enmeshed in a self-adjusting communications network adapted to one or another particular investigation, in contact with an unpredictable environment. From the practical uses of clocks, we abstract a clock enlivened with the computational capacity of a Turing machine, modified to transmit and to receive numerical communications. Such "live clocks" phase the steps of their computations to mesh with the arrival of transmitted numbers. We lift this phasing, known in digital communications, to a principle of logical synchronization, distinct from the synchronization defined by Einstein in special relativity. Logical synchronization elevates digital communication to a topic in physics, including applications to biology. One explores how feedback loops in clocking affect numerical signaling among entities functioning in the face of unpredictable influences, making the influences themselves into subjects of investigation. The formulation of communications networks in terms of live clocks extends information theory by expressing the need to actively maintain communications channels, and potentially, to create or drop them. We show how networks of live clocks are presupposed by the concept of coordinates in a spacetime. A network serves as an organizing principle, even when the concept of the rigid body that anchors a special-relativistic coordinate system is inapplicable, as is the case, for example, in a generic curved spacetime.

  16. Detection of weak frequency jumps for GNSS onboard clocks.

    Science.gov (United States)

    Huang, Xinming; Gong, Hang; Ou, Gang

    2014-05-01

    In this paper, a weak frequency jump detection method is developed for onboard clocks in global navigation satellite systems (GNSS). A Kalman filter is employed to facilitate the onboard real-time processing of atomic clock measurements, whose N-step prediction residuals are used to construct the weak frequency jump detector. Numerical simulations show that the method can successfully detect weak frequency jumps. The detection method proposed in this paper is helpful for autonomous integrity monitoring of GNSS satellite clocks, and can also be applied to other frequency anomalies with an appropriately modified detector.

  17. A mercury optical lattice clock at LNE-SYRTE

    Science.gov (United States)

    De Sarlo, L.; Favier, M.; Tyumenev, R.; Bize, S.

    2016-06-01

    We describe the development of an optical lattice clock based on mercury and the results obtained since the 7 th SFSM. We briefly present a new solution for the cooling laser system and an improved lattice trap that allows us to interrogate a few thousand atoms in parallel. This translates into a fractional short term stability of 1.2 x 10-15 at the clock frequency of 1.129 PHz.

  18. General relativistic effects in quantum interference of "clocks"

    CERN Document Server

    Zych, Magdalena; Costa, Fabio; Brukner, Časlav

    2016-01-01

    Quantum mechanics and general relativity have been each successfully tested in numerous experiments. However, the regime where both theories are jointly required to explain physical phenomena remains untested by laboratory experiments, and is also not fully understood by theory. This contribution reviews recent ideas for a new type of experiments: quantum interference of "clocks", which aim to test novel quantum effects that arise from time dilation. "Clock" interference experiments could be realised with atoms or photons in near future laboratory experiments.

  19. On clocks and clouds

    Directory of Open Access Journals (Sweden)

    M. K. Witte

    2013-09-01

    Full Text Available Cumulus clouds exhibit a life cycle that consists of: (a the growth phase (increasing size, most notably in the vertical direction; (b the mature phase (growth ceases; any precipitation that develops is strongest during this period; and (c the dissipation phase (cloud dissipates because of precipitation and/or entrainment; no more dynamical support. Although radar can track clouds over time and give some sense of the age of a cloud, most aircraft in situ measurements lack temporal context. We use large eddy simulations of trade wind cumulus cloud fields from cases during the Barbados Oceanographic and Meteorological Experiment (BOMEX and Rain In Cumulus over the Ocean (RICO campaigns to demonstrate a potential cumulus cloud "clock". We find that the volume-averaged total water mixing ratio rt is a useful cloud clock for the 12 clouds studied. A cloud's initial rt is set by the subcloud mixed-layer mean rt and decreases monotonically from the initial value due primarily to entrainment. The clock is insensitive to aerosol loading, environmental sounding and extrinsic cloud properties such as lifetime and volume. In some cases (more commonly for larger clouds, multiple pulses of buoyancy occur, which complicate the cumulus clock by replenishing rt. The clock is most effectively used to classify clouds by life phase.

  20. Frequency ratios of Sr, Yb and Hg based optical lattice clocks and their applications

    CERN Document Server

    Takamoto, Masao; Das, Manoj; Nemitz, Nils; Ohkubo, Takuya; Yamanaka, Kazuhiro; Ohmae, Noriaki; Takano, Tetsushi; Akatsuka, Tomoya; Yamaguchi, Atsushi; Katori, Hidetoshi

    2015-01-01

    This article describes the recent progress of optical lattice clocks with neutral strontium ($^{87}$Sr), ytterbium ($^{171}$Yb) and mercury ($^{199}$Hg) atoms. In particular, we present frequency comparison between the clocks locally via an optical frequency comb and between two Sr clocks at remote sites using a phase-stabilized fibre link. We first review cryogenic Sr optical lattice clocks that reduce the room-temperature blackbody radiation shift by two orders of magnitude and serve as a reference in the following clock comparisons. Similar physical properties of Sr and Yb atoms, such as transition wavelengths and vapour pressure, have allowed our development of a compatible clock for both species. A cryogenic Yb clock is evaluated by referencing a Sr clock. We also report on a Hg clock, which shows one order of magnitude less sensitivity to blackbody radiation, while its large nuclear charge makes the clock sensitive to the variation of fine-structure constant. Connecting all three types of clocks by an o...

  1. Collisional Losses, Decoherence, and Frequency Shifts in Optical Lattice Clocks with Bosons

    International Nuclear Information System (INIS)

    We have quantified collisional losses, decoherence and the collision shift in a one-dimensional optical lattice clock on the highly forbidden transition 1S0-3P0 at 698 nm with bosonic 88Sr. We were able to distinguish two loss channels: inelastic collisions between atoms in the upper and lower clock state and atoms in the upper clock state only. Based on the measured coefficients, we determine the operation parameters at which a 1D-lattice clock with 88Sr shows no degradation due to collisions on the fractional uncertainty level of 10-16.

  2. Relativistic quantum clocks

    CERN Document Server

    Lock, Maximilian P E

    2016-01-01

    The conflict between quantum theory and the theory of relativity is exemplified in their treatment of time. We examine the ways in which their conceptions differ, and describe a semiclassical clock model combining elements of both theories. The results obtained with this clock model in flat spacetime are reviewed, and the problem of generalizing the model to curved spacetime is discussed, before briefly describing an experimental setup which could be used to test of the model. Taking an operationalist view, where time is that which is measured by a clock, we discuss the conclusions that can be drawn from these results, and what clues they contain for a full quantum relativistic theory of time.

  3. Decamp Clock Board Firmware

    Energy Technology Data Exchange (ETDEWEB)

    Vicente, J. de; Castilla, J.; Martinez, G.

    2007-09-27

    Decamp (Dark Energy Survey Camera) is a new instrument designed to explore the universe aiming to reveal the nature of Dark Energy. The camera consists of 72 CCDs and 520 Mpixels. The readout electronics of DECam is based on the Monsoon system. Monsoon is a new image acquisition system developed by the NOAO (National Optical Astronomical Observatory) for the new generation of astronomical cameras. The Monsoon system uses three types of boards inserted in a Eurocard format based crate: master control board, acquisition board and clock board. The direct use of the Monsoon system for DECam readout electronics requires nine crates mainly due to the high number of clock boards needed. Unfortunately, the available space for DECam electronics is constrained to four crates at maximum. The major drawback to achieve such desired compaction degree resides in the clock board signal density. This document describes the changes performed at CIEMAT on the programmable logic of the Monsoon clock board aiming to meet such restricted space constraints. (Author) 5 refs.

  4. Cyclotomic quantum clock

    CERN Document Server

    Rosu, H C

    2003-01-01

    In the wake of our recent work on cyclotomic effects in quantum phase locking [M. Planat and H. C. Rosu, Phys. Lett. A 315, 1 (2003)], we briefly discuss here a cyclotomic extension of the Salecker and Wigner quantum clock. We also hint on a possible cyclotomic structure of time at the Planck scales

  5. Mercury Ion Clock for a NASA Technology Demonstration Mission.

    Science.gov (United States)

    Tjoelker, Robert L; Prestage, John D; Burt, Eric A; Chen, Pin; Chong, Yong J; Chung, Sang K; Diener, William; Ely, Todd; Enzer, Daphna G; Mojaradi, Hadi; Okino, Clay; Pauken, Mike; Robison, David; Swenson, Bradford L; Tucker, Blake; Wang, Rabi

    2016-07-01

    There are many different atomic frequency standard technologies but only few meet the demanding performance, reliability, size, mass, and power constraints required for space operation. The Jet Propulsion Laboratory is developing a linear ion-trap-based mercury ion clock, referred to as DSAC (Deep-Space Atomic Clock) under NASA's Technology Demonstration Mission program. This clock is expected to provide a new capability with broad application to space-based navigation and science. A one-year flight demonstration is planned as a hosted payload following an early 2017 launch. This first-generation mercury ion clock for space demonstration has a volume, mass, and power of 17 L, 16 kg, and 47 W, respectively, with further reductions planned for follow-on applications. Clock performance with a signal-to-noise ratio (SNR)*Q limited stability of 1.5E-13/τ(1/2) has been observed and a fractional frequency stability of 2E-15 at one day measured (no drift removed). Such a space-based stability enables autonomous timekeeping of with a technology capable of even higher stability, if desired. To date, the demonstration clock has been successfully subjected to mechanical vibration testing at the 14 grms level, thermal-vacuum operation over a range of 42(°)C, and electromagnetic susceptibility tests. PMID:27019481

  6. Conveyor belt clock synchronization

    CERN Document Server

    Giovannetti, V; Maccone, L; Shapiro, J H; Wong, F N C; Giovannetti, Vittorio; Lloyd, Seth; Maccone, Lorenzo; Shapiro, Jeffrey H.; Wong, Franco N. C.

    2004-01-01

    A protocol for synchronizing distant clocks is proposed that does not rely on the arrival times of the signals which are exchanged, and an optical implementation based on coherent-state pulses is described. This protocol is not limited by any dispersion that may be present in the propagation medium through which the light signals are exchanged. Possible improvements deriving from the use of quantum-mechanical effects are also addressed.

  7. Frequency ratios of optical lattice clocks at the 17th decimal place

    Science.gov (United States)

    Katori, Hidetoshi

    2016-05-01

    Optical lattice clocks benefit from a low quantum-projection noise by simultaneously interrogating a large number of atoms, which are trapped in an optical lattice tuned to the ``magic wavelength'' to largely cancel out light shift perturbation in the clock transition. About a thousand atoms enable the clocks to achieve 10-18 instability in a few hours of operation, allowing intensive investigation and control of systematic uncertainties. As optical lattice clocks have reached inaccuracies approaching 10-18, it is now the uncertainty of the SI second (~ 10-16) itself that restricts the measurement of the absolute frequencies of such optical clocks. Direct comparisons of optical clocks are, therefore, the only way to investigate and utilize their superb performance beyond the SI second. In this presentation, we report on frequency comparisons of optical lattice clocks with neutral strontium (87 Sr), ytterbium (171 Yb) and mercury (199 Hg) atoms. By referencing cryogenic Sr clocks, we determine frequency ratios, νYb/νSr and νHg/νSr, of a cryogenic Yb clock and a Hg clock with uncertainty at the mid 10-17 level. Such ratios provide an access to search for temporal variation of the fundamental constants. We also present remote comparisons between cryogenic Sr clocks located at RIKEN and the University of Tokyo over a 30-km-long phase-stabilized fiber link. The gravitational red shift Δν /ν0 ~ 1.1× 10-18 Δh cm-1 reads out the height difference of Δh ~ 15 m between the two clocks with uncertainty of 5 cm, which demonstrates a step towards relativistic geodesy. ERATO, JST.

  8. Circadian clocks and breast cancer

    OpenAIRE

    Blakeman, Victoria; Jack L. Williams; Meng, Qing-Jun; Streuli, Charles H

    2016-01-01

    Circadian clocks respond to environmental time cues to coordinate 24-hour oscillations in almost every tissue of the body. In the breast, circadian clocks regulate the rhythmic expression of numerous genes. Disrupted expression of circadian genes can alter breast biology and may promote cancer. Here we overview circadian mechanisms, and the connection between the molecular clock and breast biology. We describe how disruption of circadian genes contributes to cancer via multiple mechanisms, an...

  9. Clock Synchronisation in the Vicinity of the Earth

    OpenAIRE

    Goy, Francois

    1997-01-01

    The transmission time of an electromagnetic signal in the vicinity of the earth is calculated to c-2 and contains an orbital Sagnac term. On earth, the synchronisation of the Barycentric Coordinate Time (TCB) can be realised by atomic clocks, but not the one of Geocentric Coordinate Time (TCG). The principle of equivalence is discussed.

  10. Radium single-ion optical clock

    CERN Document Server

    Versolato, O O; Jungmann, K; Timmermans, R G E; Willmann, L; Wilschut, H W

    2011-01-01

    We explore the potential of the electric quadrupole transitions $7s\\,^2S_{1/2}$ - $6d\\,^2D_{3/2}$, $6d\\,^2D_{5/2}$ in radium isotopes as single-ion optical frequency standards. The frequency shifts of the clock transitions due to external fields and the corresponding uncertainties are calculated. Several competitive $^A$Ra$^+$ candidates with $A=$ 223 - 229 are identified. In particular, we show that the transition $7s\\,^2S_{1/2}\\,(F=2,m_F=0)$ - $6d\\,^2D_{3/2}\\,(F=0,m_F=0)$ at 828 nm in $^{223}$Ra$^+$, with no linear Zeeman and electric quadrupole shifts, stands out as a relatively simple case, which could be exploited as a compact, robust, and low-cost atomic clock operating at a fractional frequency uncertainty of $10^{-17}$. With more experimental effort, the $^{223,225,226}$Ra$^+$ clocks could be pushed to a projected performance reaching the $10^{-18}$ level.

  11. Clocks and cardiovascular function

    Science.gov (United States)

    McLoughlin, Sarah C.; Haines, Philip; FitzGerald, Garret A.

    2016-01-01

    Circadian clocks in central and peripheral tissues enable the temporal synchronization and organization of molecular and physiological processes of rhythmic animals, allowing optimum functioning of cells and organisms at the most appropriate time of day. Disruption of circadian rhythms, from external or internal forces, leads to widespread biological disruption and is postulated to underlie many human conditions, such as the incidence and timing of cardiovascular disease. Here, we describe in vivo and in vitro methodology relevant to studying the role of circadian rhythms in cardiovascular function and dysfunction PMID:25707279

  12. Strontium Optical Lattice Clock: In Quest of the Ultimate Performance

    International Nuclear Information System (INIS)

    This thesis presents the latest achievements regarding the Sr optical lattice clock experiment at LNESYRTE, Observatoire de Paris. After having described the general principles for optical lattice clocks and the operation of the clock in question, the emphasis is put on the features that have been added to the experiment since 2007. The most important new elements are an ultra-stable reference cavity for the clock laser, the development of a non-destructive detection technique, and the construction of a second Sr lattice clock. The ultra-stable cavity is constructed from a ULE spacer and fused silica mirrors and has shown a thermal noise floor at 6.5 * 10-16, placing it among the best in the world. The non-destructive detection is effectuated by a phase measurement of a weak probe beam that traverses the atoms placed in one arm of a Mach-Zender interferometer. The non-destructive aspect enables a recycling of the atoms from cycle to cycle which consequently increases the duty cycle, allowing for an increase of the stability of the clock. With these new tools the frequency stability is expected to be 2.2 * 10-16/√τ for an optimized sequence. The most recent comparisons between the two Sr clocks reach an accuracy level of 10-16 after about 1000 s, and this way we have been able to characterize lattice related frequency shifts with an unprecedented accuracy. The measurements ensure a control of lattice related effects at the 10-18 level even for trap depths as large as 50Er. (authors)

  13. Development of a strontium optical lattice clock for space applications

    Science.gov (United States)

    Singh, Yeshpal

    2016-07-01

    With timekeeping being of paramount importance for modern life, much research and major scientific advances have been undertaken in the field of frequency metrology, particularly over the last few years. New Nobel-prize winning technologies have enabled a new era of atomic clocks; namely the optical clock. These have been shown to perform significantly better than the best microwave clocks reaching an inaccuracy of 1.6x10-18 [1]. With such results being found in large lab based apparatus, the focus now has shifted to portability - to enable the accuracy of various ground based clocks to be measured, and compact autonomous performance - to enable such technologies to be tested in space. This could lead to a master clock in space, improving not only the accuracy of technologies on which modern life has come to require such as GPS and communication networks. But also more fundamentally, this could lead to the redefinition of the second and tests of fundamental physics including applications in the fields of ground based and satellite geodesy, metrology, positioning, navigation, transport and logistics etc. Within the European collaboration, Space Optical Clocks (SOC2) [2-3] consisting of various institutes and industry partners across Europe we have tried to tackle this problem of miniaturisation whilst maintaining stability, accuracy (5x10-17) and robustness whilst keeping power consumption to a minimum - necessary for space applications. We will present the most recent results of the Sr optical clock in SOC2 and also the novel compact design features, new methods employed and outlook. References [1] B. J. Bloom, T. L. Nicholson, J. R. Williams, S. L. Campbell, M. Bishof, X. Zhang, W. Zhang, S. L. Bromley, and J. Ye, "An optical lattice clock with accuracy and stability at the 10-18 level," Nature 506, 71-75 (2014). [2] S. Schiller et al. "Towards Neutral-atom Space Optical Clocks (SOC2): Development of high-performance transportable and breadboard optical clocks and

  14. Suppression of collisional shifts in a strongly interacting lattice clock

    CERN Document Server

    Swallows, Matthew D; Lin, Yige; Blatt, Sebastian; Martin, Michael J; Rey, Ana Maria; Ye, Jun

    2010-01-01

    Atomic clocks based on neutral atoms confined in optical lattices provide a unique opportunity for precise studies of quantum many-body systems. The 87Sr optical lattice clock at JILA has reached an overall fractional frequency uncertainty of 1x10^-16 [1, 2]. This uncertainty is dominated by two contributions: atomic collisions and frequency shifts due to room-temperature blackbody radiation. The density-dependent frequency shift arises from collisions between fermionic atoms that are subject to slightly inhomogeneous optical excitation [3, 4]. Several theories of the underlying frequency shift mechanism have been proposed [5-7]. A three-dimensional optical lattice clock, where each lattice site contains at most one atom, has been reported [8], and its collisional shift has been characterized with an uncertainty of 7x10^-16. Here we present a different and seemingly paradoxical solution to the problem: by strongly confining atoms in an array of quasi-one-dimensional potentials formed by a two-dimensional opti...

  15. Frequency shift due to blackbody radiation in a cesium atomic fountain and improvement of the clock performances; Deplacement de frequence du au rayonnement du corps noir dans une fontaine atomique a cesium et amelioration des performances de l'horloge

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, S

    2004-07-01

    FO1 was the first caesium fountain primary frequency standard in the world. The most recent evaluation in 2002 before improvement reached an accuracy of 1*10{sup -15} when operated with optical molasses. Working as an extremely precise and stable instrument, FO1 has contributed to fundamental physics and technical measurements: - Frequency comparison between Cs and Rb fountains over an interval of 5 years sets an upper limit for a possible variation of the fine structure constant as |alpha/alpha| < 2*10{sup -15}/y. The resolution is about 5 times better than the previous test in our laboratory. The projected accuracy of the space clock PHARAO is 1*10{sup -16}. We confirmed its Ramsey cavity performance by testing the phase difference between the two interaction zones in FO1. The measured temperature T dependent frequency shift of the Cs clock induced by the blackbody radiation field is given as nu(T)=154(6)*10{sup -6}*(T/300){sup 4}[1+{epsilon}(T/300){sup 2}] Hz with the theoretical value {epsilon} = 0,014. The obtained accuracy represents a 3 times improvement over the previous measurement by the PTB group. Some improvements have been carried out on FO1. The new FO1 version works directly with optical molasses loaded by a laser slowed atomic beam. The application of the adiabatic passage method to perform the state selection allows us to determine the atom number dependent frequency shifts due to the cold collision and cavity pulling effects at a level of of 10{sup -16}. Recently, the obtained frequency stability is 2,8*10{sup -14}*{tau}{sup -1/2} for about 4*10{sup 6} detected atoms. The accuracy is currently under evaluation, the expected value is a few times 10{sup -16}. (author)

  16. Simulating Future GPS Clock Scenarios with Two Composite Clock Algorithms

    Science.gov (United States)

    Suess, Matthias; Matsakis, Demetrios; Greenhall, Charles A.

    2010-01-01

    Using the GPS Toolkit, the GPS constellation is simulated using 31 satellites (SV) and a ground network of 17 monitor stations (MS). At every 15-minutes measurement epoch, the monitor stations measure the time signals of all satellites above a parameterized elevation angle. Once a day, the satellite clock estimates the station and satellite clocks. The first composite clock (B) is based on the Brown algorithm, and is now used by GPS. The second one (G) is based on the Greenhall algorithm. The composite clock of G and B performance are investigated using three ground-clock models. Model C simulates the current GPS configuration, in which all stations are equipped with cesium clocks, except for masers at USNO and Alternate Master Clock (AMC) sites. Model M is an improved situation in which every station is equipped with active hydrogen masers. Finally, Models F and O are future scenarios in which the USNO and AMC stations are equipped with fountain clocks instead of masers. Model F is a rubidium fountain, while Model O is more precise but futuristic Optical Fountain. Each model is evaluated using three performance metrics. The timing-related user range error having all satellites available is the first performance index (PI1). The second performance index (PI2) relates to the stability of the broadcast GPS system time itself. The third performance index (PI3) evaluates the stability of the time scales computed by the two composite clocks. A distinction is made between the "Signal-in-Space" accuracy and that available through a GNSS receiver.

  17. High-performance coherent population trapping clock with polarization modulation

    CERN Document Server

    Yun, Peter; Calosso, Claudio Eligio; Micalizio, Salvatore; François, Bruno; Boudot, Rodolphe; Guérandel, Stéphane; de Clercq, Emeric

    2016-01-01

    We demonstrate a vapor cell atomic clock prototype based on continuous-wave (CW) interrogation and double-modulation coherent population trapping (DM-CPT) technique. The DM-CPT technique uses a synchronous modulation of polarization and relative phase of a bi-chromatic laser beam in order to increase the number of atoms trapped in a dark state, i.e. a non-absorbing state. The narrow resonance, observed in transmission of a Cs vapor cell, is used as a narrow frequency discriminator in an atomic clock. A detailed characterization of the CPT resonance versus numerous parameters is reported. A short-term frequency stability of $3.2 \\times 10^{-13} \\tau^{-1/2}$ up to 100 s averaging time is measured. These performances are more than one order of magnitude better than industrial Rb clocks and comparable to those of best laboratory-prototype vapor cell clocks. The noise budget analysis shows that the short and mid-term frequency stability is mainly limited by the power fluctuations of the microwave used to generate ...

  18. Clock Genes in Glia Cells

    Science.gov (United States)

    Chi-Castañeda, Donají

    2016-01-01

    Circadian rhythms are periodic patterns in biological processes that allow the organisms to anticipate changes in the environment. These rhythms are driven by the suprachiasmatic nucleus (SCN), the master circadian clock in vertebrates. At a molecular level, circadian rhythms are regulated by the so-called clock genes, which oscillate in a periodic manner. The protein products of clock genes are transcription factors that control their own and other genes’ transcription, collectively known as “clock-controlled genes.” Several brain regions other than the SCN express circadian rhythms of clock genes, including the amygdala, the olfactory bulb, the retina, and the cerebellum. Glia cells in these structures are expected to participate in rhythmicity. However, only certain types of glia cells may be called “glial clocks,” since they express PER-based circadian oscillators, which depend of the SCN for their synchronization. This contribution summarizes the current information about clock genes in glia cells, their plausible role as oscillators and their medical implications. PMID:27666286

  19. The circadian clock in mammals

    OpenAIRE

    Zordan, Mauro; Kyriacou, Charalambos P

    2000-01-01

    The basic physiological and anatomical basis for circadian rhythms in mammalian behaviour and physiology is introduced. The pathways involved in photic entrainment of the circadian clock are discussed in relation of new findings that identify the molecules that are involved in signalling between the environment and the clock. The molecular basis of endogenous cycles is described in the mouse, and compared to the mechanism that is present in the fly. Finally we speculate on the relationship be...

  20. The circadian clock in mammals

    OpenAIRE

    Zordan, M. A.; Kyriacou, C P

    2005-01-01

    The basic physiological and anatomical basis for circadian rhythms in mammalian behaviour and physiology is introduced. The pathways involved in photic entrainment of the circadian clock are discussed in relation of new findings that identify the molecules that are involved in signalling between the environment and the clock. The molecular basis of endogenous cycles is described in the mouse, and compared to the mechanism that is present in the fly. Finally we speculate on the relationship be...

  1. Microtraps and Atom Chips: Toolboxes for Cold Atom Physics

    OpenAIRE

    Feenstra, L.; Andersson, L. M.; Schmiedmayer, J.

    2003-01-01

    Magnetic microtraps and Atom Chips are safe, small-scale, reliable and flexible tools to prepare ultra-cold and degenerate atom clouds as sources for various atom-optical experiments. We present an overview of the possibilities of the devices and indicate how a microtrap can be used to prepare and launch a Bose-Einstein condensate for use in an atom clock or an interferometer.

  2. Spin-orbit coupled fermions in an optical lattice clock

    CERN Document Server

    Kolkowitz, S; Bothwell, T; Wall, M L; Marti, G E; Koller, A P; Zhang, X; Rey, A M; Ye, J

    2016-01-01

    Engineered spin-orbit coupling (SOC) in cold atom systems can aid in the study of novel synthetic materials and complex condensed matter phenomena. Despite great advances, alkali atom SOC systems are hindered by heating from spontaneous emission, which limits the observation of many-body effects. Here we demonstrate the use of optical lattice clocks (OLCs) to engineer and study SOC with metrological precision and negligible heating. We show that clock spectroscopy of the ultra-narrow transition in fermionic 87Sr represents a momentum- and spin-resolved in situ probe of the SOC band structure and eigenstates, providing direct access to the SOC dynamics and control over lattice band populations, internal electronic states, and quasimomenta. We utilize these capabilities to study Bloch oscillations, spin-momentum locking, and van Hove singularities in the transition density of states. Our results lay the groundwork for the use of OLCs to probe novel SOC phases including magnetic crystals, helical liquids, and to...

  3. A scheme for implementing quantum clock synchronization algorithm in cavity QED

    Institute of Scientific and Technical Information of China (English)

    Wu Qin-Qin; Kuang Le-Man

    2006-01-01

    In this paper, we propose a scheme for implementing the quantum clock synchronization (QCS) algorithm in cavity quantum electrodynamic (QED) formalism. Our method is based on three-level ladder-type atoms interacting with classical and quantized cavity fields. Atom-qubit realizations of three-qubit and four-qubit QCS algorithms are explicitly presented.

  4. Circadian clocks, epigenetics, and cancer

    KAUST Repository

    Masri, Selma

    2015-01-01

    The interplay between circadian rhythm and cancer has been suggested for more than a decade based on the observations that shift work and cancer incidence are linked. Accumulating evidence implicates the circadian clock in cancer survival and proliferation pathways. At the molecular level, multiple control mechanisms have been proposed to link circadian transcription and cell-cycle control to tumorigenesis.The circadian gating of the cell cycle and subsequent control of cell proliferation is an area of active investigation. Moreover, the circadian clock is a transcriptional system that is intricately regulated at the epigenetic level. Interestingly, the epigenetic landscape at the level of histone modifications, DNA methylation, and small regulatory RNAs are differentially controlled in cancer cells. This concept raises the possibility that epigenetic control is a common thread linking the clock with cancer, though little scientific evidence is known to date.This review focuses on the link between circadian clock and cancer, and speculates on the possible connections at the epigenetic level that could further link the circadian clock to tumor initiation or progression.

  5. Testing the Gravitational Redshift with Atomic Gravimeters?

    CERN Document Server

    Wolf, Peter; Bordé, Christian J; Reynaud, Serge; Salomon, Christophe; Cohen-Tannoudji, Claude

    2011-01-01

    Atom interferometers allow the measurement of the acceleration of freely falling atoms with respect to an experimental platform at rest on Earth's surface. Such experiments have been used to test the universality of free fall by comparing the acceleration of the atoms to that of a classical freely falling object. In a recent paper, M\\"uller, Peters and Chu [Nature {\\bf 463}, 926-929 (2010)] argued that atom interferometers also provide a very accurate test of the gravitational redshift (or universality of clock rates). Considering the atom as a clock operating at the Compton frequency associated with the rest mass, they claimed that the interferometer measures the gravitational redshift between the atom-clocks in the two paths of the interferometer at different values of gravitational potentials. In the present paper we analyze this claim in the frame of general relativity and of different alternative theories, and conclude that the interpretation of atom interferometers as testing the gravitational redshift ...

  6. Cooling of rubidium atoms in pulsed diffuse laser light

    Institute of Scientific and Technical Information of China (English)

    Cheng Hua-Dong; Wang Xu-Cheng; Xiao Ling; Zhang Wen-Zhuo; Liu Liang; Wang Yu-Zhu

    2011-01-01

    This paper reports an experiment on laser cooling of 87Rb atoms in pulsed diffuse light, which is the key step towards a compact cold atom clock. It deduces an empirical formula to simulate the pulse cooling process based on the loading of cold atoms in cooling time and the loss in the dead time, which is in agreement with the experimental data. The formula gives a reference to select the parameters for the cold atom clock.

  7. Synchronous clock stopper for microprocessor

    Science.gov (United States)

    Kitchin, David A. (Inventor)

    1985-01-01

    A synchronous clock stopper circuit for inhibiting clock pulses to a microprocessor in response to a stop request signal, and for reinstating the clock pulses in response to a start request signal thereby to conserve power consumption of the microprocessor when used in an environment of limited power. The stopping and starting of the microprocessor is synchronized, by a phase tracker, with the occurrences of a predetermined phase in the instruction cycle of the microprocessor in which the I/O data and address lines of the microprocessor are of high impedance so that a shared memory connected to the I/O lines may be accessed by other peripheral devices. The starting and stopping occur when the microprocessor initiates and completes, respectively, an instruction, as well as before and after transferring data with a memory. Also, the phase tracker transmits phase information signals over a bus to other peripheral devices which signals identify the current operational phase of the microprocessor.

  8. Sr+ single-ion clock

    Science.gov (United States)

    Dubé, P.; Madej, A. A.; Jian, B.

    2016-06-01

    The evaluated uncertainty of the 88Sr+ ion optical clock has decreased by several orders of magnitude during the last 15 years, currently reaching a level of 1.2 x 10-17. In this paper, we review the methods developed to control very effectively the largest frequency shifts that once were the main sources of uncertainty for the 88Sr+ single-ion clock. These shifts are the micromotion shifts, the electric quadrupole shift and the blackbody radiation shift. With further improvements to the evaluation of the systematic shifts, especially the blackbody radiation shift, it is expected that the total uncertainty of the single-ion clock transition frequency will reach the low 10-18 level in the near future.

  9. Circadian molecular clocks and cancer.

    Science.gov (United States)

    Kelleher, Fergal C; Rao, Aparna; Maguire, Anne

    2014-01-01

    Physiological processes such as the sleep-wake cycle, metabolism and hormone secretion are controlled by a circadian rhythm adapted to 24h day-night periodicity. This circadian synchronisation is in part controlled by ambient light decreasing melatonin secretion by the pineal gland and co-ordinated by the suprachiasmatic nucleus of the hypothalamus. Peripheral cell autonomous circadian clocks controlled by the suprachiasmatic nucleus, the master regulator, exist within every cell of the body and are comprised of at least twelve genes. These include the basic helix-loop-helix/PAS domain containing transcription factors; Clock, BMal1 and Npas2 which activate transcription of the periodic genes (Per1 and Per2) and cryptochrome genes (Cry1 and Cry2). Points of coupling exist between the cellular clock and the cell cycle. Cell cycle genes which are affected by the molecular circadian clock include c-Myc, Wee1, cyclin D and p21. Therefore the rhythm of the circadian clock and cancer are interlinked. Molecular examples exist including activation of Per2 leads to c-myc overexpression and an increased tumor incidence. Mice with mutations in Cryptochrome 1 and 2 are arrhythmic (lack a circadian rhythm) and arrhythmic mice have a faster rate of growth of implanted tumors. Epidemiological finding of relevance include 'The Nurses' Health Study' where it was established that women working rotational night shifts have an increased incidence of breast cancer. Compounds that affect circadian rhythm exist with attendant future therapeutic possibilities. These include casein kinase I inhibitors and a candidate small molecule KL001 that affects the degradation of cryptochrome. Theoretically the cell cycle and malignant disease may be targeted vicariously by selective alteration of the cellular molecular clock. PMID:24099911

  10. Circadian clock components in the rat neocortex

    DEFF Research Database (Denmark)

    Rath, Martin Fredensborg; Rohde, Kristian; Fahrenkrug, Jan;

    2013-01-01

    have shown the presence of peripheral clocks in extra-hypothalamic areas of the central nervous system. However, knowledge on the clock gene network in the cerebral cortex is limited. We here show that the mammalian clock genes Per1, Per2, Per3, Cry1, Cry2, Bmal1, Clock, Nr1d1 and Dbp are expressed...... expression in the neocortex is dependent on the SCN. In situ hybridization and immunohistochemistry showed that products of the canonical clock gene Per2 are located in perikarya throughout all areas of the neocortex. These findings show that local circadian oscillators driven by the SCN reside within......The circadian master clock of the mammalian brain resides in the suprachiasmatic nucleus (SCN) of the hypothalamus. At the molecular level, the clock of the SCN is driven by a transcriptional/posttranslational autoregulatory network with clock gene products as core elements. Recent investigations...

  11. The NIST 27 Al+ quantum-logic clock

    Science.gov (United States)

    Leibrandt, David; Brewer, Samuel; Chen, Jwo-Sy; Hume, David; Hankin, Aaron; Huang, Yao; Chou, Chin-Wen; Rosenband, Till; Wineland, David

    2016-05-01

    Optical atomic clocks based on quantum-logic spectroscopy of the 1 S0 3 P0 transition in 27 Al+ have reached a systematic fractional frequency uncertainty of 8 . 0 ×10-18 , enabling table-top tests of fundamental physics as well as measurements of gravitational potential differences. Currently, the largest limitations to the accuracy are second order time dilation shifts due to the driven motion (i.e., micromotion) and thermal motion of the trapped ions. In order to suppress these shifts, we have designed and built new ion traps based on gold-plated, laser-machined diamond wafers with differential RF drive, and we have operated one of our clocks with the ions laser cooled to near the six mode motional ground state. We present a characterization of the time dilation shifts in the new traps with uncertainties near 1 ×10-18 . Furthermore, we describe a new protocol for clock comparison measurements based on synchronous probing of the two clocks using phase-locked local oscillators, which allows for probe times longer than the laser coherence time and avoids the Dick effect. This work is supported by ARO, DARPA, and ONR.

  12. Metrological characterization of the pulsed Rb clock with optical detection

    CERN Document Server

    Micalizio, Salvatore; Godone, Aldo; Levi, Filippo

    2011-01-01

    We report on the implementation and the metrological characterization of a vapor-cell Rb frequency standard working in pulsed regime. The three main parts that compose the clock, physics package, optics and electronics, are described in detail in the paper. The prototype is designed and optimized to detect the clock transition in the optical domain. Specifically, the reference atomic transition, excited with a Ramsey scheme, is detected by observing the interference pattern on a laser absorption signal. \\ The metrological analysis includes the observation and characterization of the clock signal and the measurement of frequency stability and drift. In terms of Allan deviation, the measured frequency stability results as low as $1.7\\times 10^{-13} \\ \\tau^{-1/2}$, $\\tau$ being the averaging time, and reaches the value of few units of $10^{-15}$ for $\\tau=10^{4}$ s, an unprecedent achievement for a vapor cell clock. We discuss in the paper the physical effects leading to this result with particular care to laser...

  13. BMAL1 and CLOCK, two essential components of the circadian clock, are involved in glucose homeostasis.

    Directory of Open Access Journals (Sweden)

    R Daniel Rudic

    2004-11-01

    Full Text Available Circadian timing is generated through a unique series of autoregulatory interactions termed the molecular clock. Behavioral rhythms subject to the molecular clock are well characterized. We demonstrate a role for Bmal1 and Clock in the regulation of glucose homeostasis. Inactivation of the known clock components Bmal1 (Mop3 and Clock suppress the diurnal variation in glucose and triglycerides. Gluconeogenesis is abolished by deletion of Bmal1 and is depressed in Clock mutants, but the counterregulatory response of corticosterone and glucagon to insulin-induced hypoglycaemia is retained. Furthermore, a high-fat diet modulates carbohydrate metabolism by amplifying circadian variation in glucose tolerance and insulin sensitivity, and mutation of Clock restores the chow-fed phenotype. Bmal1 and Clock, genes that function in the core molecular clock, exert profound control over recovery from insulin-induced hypoglycaemia. Furthermore, asynchronous dietary cues may modify glucose homeostasis via their interactions with peripheral molecular clocks.

  14. Light and the human circadian clock

    NARCIS (Netherlands)

    Roenneberg, Till; Kantermann, Thomas; Juda, Myriam; Vetter, Céline; Allebrandt, Karla V

    2013-01-01

    The circadian clock can only reliably fulfil its function if it is stably entrained. Most clocks use the light-dark cycle as environmental signal (zeitgeber) for this active synchronisation. How we think about clock function and entrainment has been strongly influenced by the early concepts of the f

  15. A generalized gravitomagnetic clock effect

    CERN Document Server

    Hackmann, Eva

    2014-01-01

    In General Relativity the rotation of a gravitating body like the Earth influences the motion of orbiting test particles or satellites in a non-Newtonian way. This causes e.g. a precession of the orbital plane, known as the Lense-Thirring effect, and a precession of the spin of a gyroscope, known as the Schiff effect. Here we discuss a third effect, first introduced by Cohen and Mashhoon, called the gravitomagnetic clock effect. It describes the difference in proper time of counter revolving clocks after a revolution of $2\\pi$. For two clocks on counter rotating equatorial circular orbits around the Earth the effect is about $10^{-7}$ seconds per revolution, which is quite large. We introduce a general relativistic definition of the gravitomagnetic clock effect which is valid for arbitrary pairs of orbits. This includes rotations in the same direction and different initial conditions, which is crucial if the effect can be detected with existing satellites or with payloads on non-dedicated missions. We also de...

  16. Biological clocks: riding the tides.

    Science.gov (United States)

    de la Iglesia, Horacio O; Johnson, Carl Hirschie

    2013-10-21

    Animals with habitats in the intertidal zone often display biological rhythms that coordinate with both the tidal and the daily environmental cycles. Two recent studies show that the molecular components of the biological clocks mediating tidal rhythms are likely different from the phylogenetically conserved components that mediate circadian (daily) rhythms.

  17. Cryogenic optical lattice clocks with a relative frequency difference of $1\\times 10^{-18}$

    CERN Document Server

    Ushijima, Ichiro; Das, Manoj; Ohkubo, Takuya; Katori, Hidetoshi

    2014-01-01

    Time and frequency are the most accurately measurable quantities, providing foundations for science and modern technologies. The accuracy relies on the SI (Syst\\'eme International) second that refers to Cs microwave clocks with fractional uncertainties at $10^{-16}$. Recent revolutionary progress of optical clocks aims to achieve $1\\times 10^{-18}$ uncertainty, which however has been hindered by long averaging-times or by systematic uncertainties. Here, we demonstrate optical lattice clocks with $^{87}$Sr atoms interrogated in a cryogenic environment to address the blackbody radiation-induced frequency-shift, which remains the primary source of clocks' uncertainties and has initiated vigorous theoretical and experimental investigations. The quantum-limited stability for $N \\sim 1,000$ atoms allows investigation of the uncertainties at $2\\times 10^{-18}$ in two hours of clock operation. After 11 measurements performed over a month, the two cryo-clocks agree to within $(-1.1\\pm 1.6)\\times 10^{-18}$. Besides its...

  18. Circadian clock, cell cycle and cancer

    Directory of Open Access Journals (Sweden)

    Cansu Özbayer

    2011-12-01

    Full Text Available There are a few rhythms of our daily lives that we are under the influence. One of them is characterized by predictable changes over a 24-hour timescale called circadian clock. This cellular clock is coordinated by the suprachiasmatic nucleus in the anterior hypothalamus. The clock consist of an autoregulatory transcription-translation feedback loop compose of four genes/proteins; BMAL1, Clock, Cyrptochrome, and Period. BMAL 1 and Clock are transcriptional factors and Period and Cyrptochrome are their targets. Period and Cyrptochrome dimerize in the cytoplasm to enter the nucleus where they inhibit Clock/BMAL activity.It has been demonstrate that circadian clock plays an important role cellular proliferation, DNA damage and repair mechanisms, checkpoints, apoptosis and cancer.

  19. Recent progress in optically-pumped cesium beam clock at Peking University

    Science.gov (United States)

    Liu, C.; Zhou, S.; Wan, J.; Wang, S.; Wang, Y.

    2016-06-01

    A compact, long-life, and low-drift cesium beam clock is investigated at Peking University, where the atoms are magnetic-state selected and optically detected. Stability close to that of the best commercial cesium clocks has been achieved from 10 to 105 s. As previously shown, the short-term stability is determined by atomic shot noise or laser frequency noise. The stabilizations of microwave power and C-field improve the long-term stability, with the help of a digital servo system based on field-programmable gate array.

  20. Synthetic dimensions and spin-orbit coupling with an optical clock transition

    CERN Document Server

    Livi, L F; Diem, M; Franchi, L; Clivati, C; Frittelli, M; Levi, F; Calonico, D; Catani, J; Inguscio, M; Fallani, L

    2016-01-01

    We demonstrate a novel way of synthesizing spin-orbit interactions in ultracold quantum gases, based on a single-photon optical clock transition coupling two long-lived electronic states of two-electron $^{173}$Yb atoms. By mapping the electronic states onto effective sites along a synthetic "electronic" dimension, we have engineered synthetic fermionic ladders with tunable magnetic fluxes. We have detected the spin-orbit coupling with fiber-link-enhanced clock spectroscopy and directly measured the emergence of chiral edge currents, probing them as a function of the magnetic field flux. These results open new directions for the investigation of topological states of matter with ultracold atomic gases.

  1. Mercury Atomic Frequency Standards for Space Based Navigation and Timekeeping

    Science.gov (United States)

    Tjoelker, R. L.; Burt, E. A.; Chung, S.; Hamell, R. L.; Prestage, J. D.; Tucker, B.; Cash, P.; Lutwak, R.

    2012-01-01

    A low power Mercury Atomic Frequency Standard (MAFS) has been developed and demonstrated on the path towards future space clock applications. A self contained mercury ion breadboard clock: emulating flight clock interfaces, steering a USO local oscillator, and consuming approx 40 Watts has been operating at JPL for more than a year. This complete, modular ion clock instrument demonstrates that key GNSS size, weight, and power (SWaP) requirements can be achieved while still maintaining short and long term performance demonstrated in previous ground ion clocks. The MAFS breadboard serves as a flexible platform for optimizing further space clock development and guides engineering model design trades towards fabrication of an ion clock for space flight.

  2. Prediction of Navigation Satellite Clock Bias Considering Clock's Stochastic Variation Behavior with Robust Least Square Collocation

    Directory of Open Access Journals (Sweden)

    WANG Yupu

    2016-06-01

    Full Text Available In order to better express the characteristic of satellite clock bias (SCB and further improve its prediction precision, a new SCB prediction model is proposed, which can take the physical feature, cyclic variation and stochastic variation behaviors of the space-borne atomic clock into consideration by using a robust least square collocation (LSC method. The proposed model firstly uses a quadratic polynomial model with periodic terms to fit and abstract the trend term and cyclic terms of SCB. Then for the residual stochastic variation part and possible gross errors hidden in SCB data, the model employs a robust LSC method to process them. The covariance function of the LSC is determined by selecting an empirical function and combining SCB prediction tests. Using the final precise IGS SCB products to conduct prediction tests, the results show that the proposed model can get better prediction performance. Specifically, the results' prediction accuracy can enhance 0.457 ns and 0.948 ns respectively, and the corresponding prediction stability can improve 0.445 ns and 1.233 ns, compared with the results of quadratic polynomial model and grey model. In addition, the results also show that the proposed covariance function corresponding to the new model is reasonable.

  3. Design principles underlying circadian clocks.

    OpenAIRE

    Rand, D.A.; Shulgin, B. V.; D. Salazar; Millar, A. J.

    2004-01-01

    A fundamental problem for regulatory networks is to understand the relation between form and function: to uncover the underlying design principles of the network. Circadian clocks present a particularly interesting instance, as recent work has shown that they have complex structures involving multiple interconnected feedback loops with both positive and negative feedback. While several authors have speculated on the reasons for this, a convincing explanation is still lacking.We analyse both t...

  4. Researchers Discover Plants Biological Clock

    Institute of Scientific and Technical Information of China (English)

    王全良

    1996-01-01

    Scientists who created glow-in-the-dark plants by shooting up seedlingswith firefly DNA have identified the first biological clock gene in plants. Discovery of the timepiece gene, which controls such biological rhythmsas daily leaf movements and proe openings, flower-blooming schedules andphotosynthesis cycles, could lead to a host of applications in ornamental horti-culture, agriculture and even human health. Many researchers believe that

  5. An epigenetic clock controls aging.

    Science.gov (United States)

    Mitteldorf, Josh

    2016-02-01

    We are accustomed to treating aging as a set of things that go wrong with the body. But for more than twenty years, there has been accumulating evidence that much of the process takes place under genetic control. We have seen that signaling chemistry can make dramatic differences in life span, and that single molecules can significantly affect longevity. We are frequently confronted with puzzling choices the body makes which benefit neither present health nor fertility nor long-term survival. If we permit ourselves a shift of reference frame and regard aging as a programmed biological function like growth and development, then these observations fall into place and make sense. This perspective suggests that aging proceeds under control of a master clock, or several redundant clocks. If this is so, we may learn to reset the clocks with biochemical interventions and make an old body behave like a young body, including repair of many of the modes of damage that we are accustomed to regard as independent symptoms of the senescent phenotype, and for which we have assumed that the body has no remedy. PMID:26608516

  6. The circadian clock coordinates ribosome biogenesis.

    Directory of Open Access Journals (Sweden)

    Céline Jouffe

    Full Text Available Biological rhythms play a fundamental role in the physiology and behavior of most living organisms. Rhythmic circadian expression of clock-controlled genes is orchestrated by a molecular clock that relies on interconnected negative feedback loops of transcription regulators. Here we show that the circadian clock exerts its function also through the regulation of mRNA translation. Namely, the circadian clock influences the temporal translation of a subset of mRNAs involved in ribosome biogenesis by controlling the transcription of translation initiation factors as well as the clock-dependent rhythmic activation of signaling pathways involved in their regulation. Moreover, the circadian oscillator directly regulates the transcription of ribosomal protein mRNAs and ribosomal RNAs. Thus the circadian clock exerts a major role in coordinating transcription and translation steps underlying ribosome biogenesis.

  7. Frequency ratio of Yb and Sr clocks with $5 \\times 10^{-17}$ uncertainty at 150 s averaging time

    CERN Document Server

    Nemitz, Nils; Takamoto, Masao; Ushijima, Ichiro; Das, Manoj; Ohmae, Noriaki; Katori, Hidetoshi

    2016-01-01

    Transition frequencies of atoms and ions are among the most accurately accessible quantities in nature, playing important roles in pushing the frontiers of science by testing fundamental laws of physics, in addition to a wide range of applications such as satellite navigation systems. Atomic clocks based on optical transitions approach uncertainties of $10^{-18}$, where full frequency descriptions are far beyond the reach of the SI second. Frequency ratios of such super clocks, on the other hand, are not subject to this limitation. They can therefore verify consistency and overall accuracy for an ensemble of super clocks, an essential step towards a redefinition of the second. However, with the measurement stabilities so far reported for such frequency ratios, a confirmation to $1 \\times 10^{-18}$ uncertainty would require an averaging time $\\tau$ of multiple months. Here we report a measurement of the frequency ratio of neutral ytterbium and strontium clocks with a much improved stability of $4 \\times 10^{-1...

  8. Interaction of circadian clock proteins PER2 and CRY with BMAL1 and CLOCK

    OpenAIRE

    Bordon Alain; Tallone Tiziano; Langmesser Sonja; Rusconi Sandro; Albrecht Urs

    2008-01-01

    Abstract Background Circadian oscillation of clock-controlled gene expression is mainly regulated at the transcriptional level. Heterodimers of CLOCK and BMAL1 act as activators of target gene transcription; however, interactions of PER and CRY proteins with the heterodimer abolish its transcriptional activation capacity. PER and CRY are therefore referred to as negative regulators of the circadian clock. To further elucidate the mechanism how positive and negative components of the clock int...

  9. Comparing a mercury optical lattice clock with microwave and optical frequency standards

    CERN Document Server

    Tyumenev, R; Bilicki, S; Bookjans, E; Targat, R Le; Lodewyck, J; Nicolodi, D; Coq, Y Le; Abgrall, M; Guéna, J; De Sarlo, L; Bize, S

    2016-01-01

    In this paper we report the evaluation of an optical lattice clock based on neutral mercury down to a relative uncertainty of $1.7\\times 10^{-16}$. Comparing this characterized frequency standard to a Cs atomic fountain we determine the absolute frequency of the $^1S_0 \\rightarrow \\phantom{}^3P_0$ transition of $^{199}$Hg as $\

  10. A quantum many-body spin system in an optical lattice clock

    CERN Document Server

    Martin, M J; Swallows, M D; Zhang, X; Benko, C; von-Stecher, J; Gorshkov, A V; Rey, A M; Ye, Jun

    2013-01-01

    Strongly interacting quantum many-body systems are fundamentally compelling and ubiquitous in science. However, their complexity generally prevents exact solutions of their dynamics. Precisely engineered ultracold atomic gases are emerging as a powerful tool to unravel these challenging physical problems. Here we present a new laboratory for the study of many-body effects: strongly interacting two-level systems formed by the clock states in ${}^{87}$Sr, which are used to realize a neutral atom optical clock that performs at the highest level of optical-atomic coherence and with precision near the limit set by quantum fluctuations. Our measurements of the collective spin evolution reveal signatures of many-body dynamics, including beyond-mean-field effects. We derive a many-body Hamiltonian that describes the experimental observation of severely distorted lineshapes, atomic spin coherence decay, density-dependent frequency shifts, and correlated quantum spin noise. These investigations open the door to explori...

  11. Laser Cooling of Lanthanides: from Optical Clocks to Quantum Simulators

    Directory of Open Access Journals (Sweden)

    Golovizin A.

    2015-01-01

    Full Text Available We discuss current progress in laser cooling of lanthanides (Er, Yb, Dy, Tm etc. focusing on applications. We describe some important peculiarities taking Thulium atom as an example: Two stage laser cooling, trapping in an optical lattice, anisotropic interactions and spectroscopy of narrow transitions. Specific level structure and presence of magic wavelengths make ultracold Thulium a favorable candidate for optical clock applications. On the other hand, abundance of Feshbach resonances allow to tune interactions in ultracold gases and thus reach quantum degeneracy. It opens intriguing perspectives for novel quantum simulators employing dipole-dipole interactions in an optical lattice.

  12. Prospect for a compact strontium optical lattice clock

    OpenAIRE

    Poli, N.; Drullinger, R. E.; Ferrari, G; Prevedelli, M.; M. G. Tarallo; Tino, G. M.

    2007-01-01

    We report on our progress toward the realization of a compact optical frequency standard referenced to strontium intercombination lines. Our current setup allows the production of ultracold Sr atoms in hundreds of ms. For high resolution spectroscopy of the 1S0-3P0 doubly forbidden transition we have prepared a 698 nm clock laser stabilized on a high finesse, symmetrically suspended cavity and a high power 813 nm light source for the optical lattice trap at the magic wavelength. Due to their ...

  13. Strontium optical lattice clock with all semiconductor sources

    OpenAIRE

    Poli, N.; Drullinger, R. E.; M. G. Tarallo; Tino, G. M.

    2007-01-01

    We report on our progress toward the realization of an optical frequency standard referenced to strontium intercombination lines. Our current setup allows the production of ultracold Sr atoms in hundreds of ms. For high resolution spectroscopy of 1S0-3P0 doubly forbidden transition we have also prepared a 698 nm clock laser stabilized on high finesse symmetrically suspended cavity and a high power 813 nm light source for the optical lattice trap at the magic wavelength. All the laser source e...

  14. Circadian molecular clock in lung pathophysiology.

    Science.gov (United States)

    Sundar, Isaac K; Yao, Hongwei; Sellix, Michael T; Rahman, Irfan

    2015-11-15

    Disrupted daily or circadian rhythms of lung function and inflammatory responses are common features of chronic airway diseases. At the molecular level these circadian rhythms depend on the activity of an autoregulatory feedback loop oscillator of clock gene transcription factors, including the BMAL1:CLOCK activator complex and the repressors PERIOD and CRYPTOCHROME. The key nuclear receptors and transcription factors REV-ERBα and RORα regulate Bmal1 expression and provide stability to the oscillator. Circadian clock dysfunction is implicated in both immune and inflammatory responses to environmental, inflammatory, and infectious agents. Molecular clock function is altered by exposomes, tobacco smoke, lipopolysaccharide, hyperoxia, allergens, bleomycin, as well as bacterial and viral infections. The deacetylase Sirtuin 1 (SIRT1) regulates the timing of the clock through acetylation of BMAL1 and PER2 and controls the clock-dependent functions, which can also be affected by environmental stressors. Environmental agents and redox modulation may alter the levels of REV-ERBα and RORα in lung tissue in association with a heightened DNA damage response, cellular senescence, and inflammation. A reciprocal relationship exists between the molecular clock and immune/inflammatory responses in the lungs. Molecular clock function in lung cells may be used as a biomarker of disease severity and exacerbations or for assessing the efficacy of chronotherapy for disease management. Here, we provide a comprehensive overview of clock-controlled cellular and molecular functions in the lungs and highlight the repercussions of clock disruption on the pathophysiology of chronic airway diseases and their exacerbations. Furthermore, we highlight the potential for the molecular clock as a novel chronopharmacological target for the management of lung pathophysiology.

  15. Superradiance on the mHz linewidth clock transition in 87Sr

    Science.gov (United States)

    Norcia, Matthew; Winchester, Matthew; Cline, Julia; Thompson, James

    2016-05-01

    In this talk, I will discuss our recent experimental explorations of superradiant emission from the mHz linewidth clock transition in an ensemble of cold 87 Sr atoms confined within a high-finesse optical cavity. Recent proposals suggest that superradiant lasers based on such dipole-forbidden transitions in alkaline earth atoms could achieve linewidths below the current state of the art, with reduced sensitivity to environmental perturbations.

  16. The absolute frequency of the 87Sr optical clock transition

    DEFF Research Database (Denmark)

    Campbell, Gretchen K.; Ludlow, Andrew D.; Blatt, Sebastian;

    2008-01-01

    The absolute frequency of the 1S0–3P0 clock transition of 87Sr has been measured to be 429 228 004 229 873.65 (37) Hz using lattice-confined atoms, where the fractional uncertainty of 8.6 × 10-16 represents one of the most accurate measurements of an atomic transition frequency to date. After a d...

  17. Atom gravimeters and gravitational redshift

    CERN Document Server

    Wolf, Peter; Borde, Christian J; Reynaud, Serge; Salomon, Christophe; Cohen-Tannoudji, Claude; 10.1038/nature09340

    2010-01-01

    In a recent paper, H. Mueller, A. Peters and S. Chu [A precision measurement of the gravitational redshift by the interference of matter waves, Nature 463, 926-929 (2010)] argued that atom interferometry experiments published a decade ago did in fact measure the gravitational redshift on the quantum clock operating at the very high Compton frequency associated with the rest mass of the Caesium atom. In the present Communication we show that this interpretation is incorrect.

  18. Tectonic blocks and molecular clocks

    Science.gov (United States)

    2016-01-01

    Evolutionary timescales have mainly used fossils for calibrating molecular clocks, though fossils only really provide minimum clade age constraints. In their place, phylogenetic trees can be calibrated by precisely dated geological events that have shaped biogeography. However, tectonic episodes are protracted, their role in vicariance is rarely justified, the biogeography of living clades and their antecedents may differ, and the impact of such events is contingent on ecology. Biogeographic calibrations are no panacea for the shortcomings of fossil calibrations, but their associated uncertainties can be accommodated. We provide examples of how biogeographic calibrations based on geological data can be established for the fragmentation of the Pangaean supercontinent: (i) for the uplift of the Isthmus of Panama, (ii) the separation of New Zealand from Gondwana, and (iii) for the opening of the Atlantic Ocean. Biogeographic and fossil calibrations are complementary, not competing, approaches to constraining molecular clock analyses, providing alternative constraints on the age of clades that are vital to avoiding circularity in investigating the role of biogeographic mechanisms in shaping modern biodiversity. This article is part of the themed issue ‘Dating species divergences using rocks and clocks’. PMID:27325840

  19. Single electron relativistic clock interferometer

    Science.gov (United States)

    Bushev, P. A.; Cole, J. H.; Sholokhov, D.; Kukharchyk, N.; Zych, M.

    2016-09-01

    Although time is one of the fundamental notions in physics, it does not have a unique description. In quantum theory time is a parameter ordering the succession of the probability amplitudes of a quantum system, while according to relativity theory each system experiences in general a different proper time, depending on the system's world line, due to time dilation. It is therefore of fundamental interest to test the notion of time in the regime where both quantum and relativistic effects play a role, for example, when different amplitudes of a single quantum clock experience different magnitudes of time dilation. Here we propose a realization of such an experiment with a single electron in a Penning trap. The clock can be implemented in the electronic spin precession and its time dilation then depends on the radial (cyclotron) state of the electron. We show that coherent manipulation and detection of the electron can be achieved already with present day technology. A single electron in a Penning trap is a technologically ready platform where the notion of time can be probed in a hitherto untested regime, where it requires a relativistic as well as quantum description.

  20. Temperature influences in receiver clock modelling

    Science.gov (United States)

    Wang, Kan; Meindl, Michael; Rothacher, Markus; Schoenemann, Erik; Enderle, Werner

    2016-04-01

    In Precise Point Positioning (PPP), hardware delays at the receiver site (receiver, cables, antenna, …) are always difficult to be separated from the estimated receiver clock parameters. As a result, they are partially or fully contained in the estimated "apparent" clocks and will influence the deterministic and stochastic modelling of the receiver clock behaviour. In this contribution, using three years of data, the receiver clock corrections of a set of high-precision Hydrogen Masers (H-Masers) connected to stations of the ESA/ESOC network and the International GNSS Service (IGS) are firstly characterized concerning clock offsets, drifts, modified Allan deviations and stochastic parameters. In a second step, the apparent behaviour of the clocks is modelled with the help of a low-order polynomial and a known temperature coefficient (Weinbach, 2013). The correlations between the temperature and the hardware delays generated by different types of antennae are then analysed looking at daily, 3-day and weekly time intervals. The outcome of these analyses is crucial, if we intend to model the receiver clocks in the ground station network to improve the estimation of station-related parameters like coordinates, troposphere zenith delays and ambiguities. References: Weinbach, U. (2013) Feasibility and impact of receiver clock modeling in precise GPS data analysis. Dissertation, Leibniz Universität Hannover, Germany.

  1. Network properties of the mammalian circadian clock

    NARCIS (Netherlands)

    Rohling, Johannes Hermanus Theodoor

    2009-01-01

    The biological clock regulates daily and seasonal rhythms in mammals. This clock is located in the suprachiasmatic nuclei (SCN), which are two small nuclei each consisting of 10,000 neurons. The neurons of the SCN endogenously generate a rhythm of approximately 24 hours. Under the influence of the l

  2. A circadian clock in Saccharomyces cerevisiae

    NARCIS (Netherlands)

    Eelderink-Chen, Zheng; Mazzotta, Gabriella; Sturre, Marcel; Bosman, Jasper; Roenneberg, Till; Merrow, Martha

    2010-01-01

    Circadian timing is a fundamental biological process, underlying cellular physiology in animals, plants, fungi, and cyanobacteria. Circadian clocks organize gene expression, metabolism, and behavior such that they occur at specific times of day. The biological clocks that orchestrate these daily cha

  3. A colorful model of the circadian clock.

    Science.gov (United States)

    Reppert, Steven M

    2006-01-27

    The migration of the colorful monarch butterfly provides biologists with a unique model system with which to study the cellular and molecular mechanisms underlying a sophisticated circadian clock. The monarch circadian clock is involved in the induction of the migratory state and navigation over long distances, using the sun as a compass. PMID:16439193

  4. "Molecular Clock" Analogs: A Relative Rates Exercise

    Science.gov (United States)

    Wares, John P.

    2008-01-01

    Although molecular clock theory is a commonly discussed facet of evolutionary biology, undergraduates are rarely presented with the underlying information of how this theory is examined relative to empirical data. Here a simple contextual exercise is presented that not only provides insight into molecular clocks, but is also a useful exercise for…

  5. A clock synchronization skeleton based on RTAI

    NARCIS (Netherlands)

    Huang, Y.; Visser, P.M.; Broenink, J.F.

    2006-01-01

    This paper presents a clock synchronization skeleton based on RTAI (Real Time Application Interface). The skeleton is a thin layer that provides unified but extendible interfaces to the underlying operating system, the synchronization algorithms and the upper level applications in need of clock sync

  6. Fast Clock Recovery for Digital Communications

    Science.gov (United States)

    Tell, R. G.

    1985-01-01

    Circuit extracts clock signal from random non-return-to-zero data stream, locking onto clock within one bit period at 1-gigabitper-second data rate. Circuit used for synchronization in opticalfiber communications. Derives speed from very short response time of gallium arsenide metal/semiconductor field-effect transistors (MESFET's).

  7. Cost and Precision of Brownian Clocks

    CERN Document Server

    Barato, Andre C

    2016-01-01

    Brownian clocks are biomolecular networks that can count time. A paradigmatic example are proteins that go through a cycle thus regulating some oscillatory behaviour in a living system. Typically, such a cycle requires free energy often provided by ATP hydrolysis. We investigate the relation between the precision of such a clock and its thermodynamic costs. For clocks driven by a constant thermodynamic force, a given precision requires a minimal cost that diverges as the uncertainty of the clock vanishes. In marked contrast, we show that a clock driven by a periodic variation of an external protocol can achieve arbitrary precision at arbitrarily low cost. This result constitutes a fundamental difference between processes driven by a fixed thermodynamic force and those driven periodically. As a main technical tool, we map a periodically driven system with a deterministic protocol to one subject to an external protocol that changes in stochastic time intervals, which simplifies calculations significantly. In th...

  8. An atomic clockwork using phase dependent energy shifts

    CERN Document Server

    De Munshi, D; Mukherjee, M

    2011-01-01

    A frequency stabilized laser referenced to an unperturbed atomic two level system acts as the most accurate clock with femtosecond clock ticks. For any meaningful use, a Femtosecond Laser Frequency Comb (FLFC) is used to transfer the atomic clock accuracy to electronically countable nanosecond clock ticks. Here we propose an alternative clockwork based on the phenomenon that when an atomic system is slowly evolved in a cyclic path, the atomic energy levels gather some phase called the geometric phase. This geometric phase dependent energy shift has been used here to couple the two frequency regimes in a phase coherent manner. It has also been shown that such a technique can be implemented experimentally, bypassing the highly involved setup of a FLFC.

  9. Frequency shifts in an optical lattice clock due to magnetic-dipole and electric-quadrupole transitions.

    Science.gov (United States)

    Taichenachev, A V; Yudin, V I; Ovsiannikov, V D; Pal'chikov, V G; Oates, C W

    2008-11-01

    We report a hitherto undiscovered frequency shift for forbidden J = 0-->J = 0 clock transitions excited in atoms confined to an optical lattice. These shifts result from magnetic-dipole and electric-quadrupole transitions, which have a spatial dependence in an optical lattice that differs from that of the stronger electric-dipole transitions. In combination with the residual translational motion of atoms in an optical lattice, this spatial mismatch leads to a frequency shift via differential energy level spacing in the lattice wells for ground state and excited state atoms. We estimate that this effect could lead to fractional frequency shifts as large as 10(-16), which might prevent lattice-based optical clocks from reaching their predicted performance levels. Moreover, these effects could shift the magic wavelength in lattice clocks in three dimensions by as much as 100 MHz, depending on the lattice configuration.

  10. Synthetic Frequency Protocol in the Ramsey Spectroscopy of Clock Transitions

    CERN Document Server

    Yudin, V I; Basalaev, M Yu

    2016-01-01

    We develop an universal method to significantly suppress probe-induced shifts in any types of atomic clocks using the Ramsey spectroscopy. Our approach is based on adaptation of the synthetic frequency concept [V. I. Yudin, et al., Phys. Rev. Lett. 107, 030801 (2011)] (previously developed for BBR shift suppression) to the Ramsey spectroscopy with the use of interrogations for different dark time intervals. Universality of the method consists in arbitrariness of the possible Ramsey schemes. However, most extremal results are obtained in combination with so-called hyper-Ramsey spectroscopy [V. I. Yudin, et al., Phys. Rev. A 82, 011804(R) (2010)]. In the latter case, the probe-induced frequency shifts can be suppressed considerably below a fractional level of 10$^{-18}$ practically for any optical atomic clocks, where this shift previously was metrologically significant. The main advantage of our method in comparison with other radical hyper-Ramsey approaches [R. Hobson, et al., Phys. Rev. A 93, 010501(R) (2016...

  11. Raman transitions between hyperfine clock states in a magnetic trap

    CERN Document Server

    Naber, J B; Hubert, T; Spreeuw, R J C

    2016-01-01

    We present our experimental investigation of an optical Raman transition between the magnetic clock states of $^{87}$Rb in an atom chip magnetic trap. The transfer of atomic population is induced by a pair of diode lasers which couple the two clock states off-resonantly to an intermediate state manifold. This transition is subject to destructive interference of two excitation paths, which leads to a reduction of the effective two-photon Rabi-frequency. Furthermore, we find that the transition frequency is highly sensitive to the intensity ratio of the diode lasers. Our results are well described in terms of light shifts in the multi-level structure of $^{87}$Rb. The differential light shifts vanish at an optimal intensity ratio, which we observe as a narrowing of the transition linewidth. We also observe the temporal dynamics of the population transfer and find good agreement with a model based on the system's master equation and a Gaussian laser beam profile. Finally, we identify several sources of decoheren...

  12. Circadian clocks are designed optimally

    CERN Document Server

    Hasegawa, Yoshihiko

    2014-01-01

    Circadian rhythms are acquired through evolution to increase the chances for survival by synchronizing to the daylight cycle. Reliable synchronization is realized through two trade-off properties: regularity to keep time precisely, and entrainability to synchronize the internal time with daylight. Since both properties have been tuned through natural selection, their adaptation can be formalized in the framework of mathematical optimization. By using a succinct model, we found that simultaneous optimization of regularity and entrainability entails inherent features of the circadian mechanism irrespective of model details. At the behavioral level we discovered the existence of a dead zone, a time during which light pulses neither advance nor delay the clock. At the molecular level we demonstrate the role-sharing of two light inputs, phase advance and delay, as is well observed in mammals. We also reproduce the results of phase-controlling experiments and predict molecular elements responsible for the clockwork...

  13. Time clock requirements for hospital physicians.

    Science.gov (United States)

    Shapira, Chen; Vilnai-Yavetz, Iris; Rafaeli, Anat; Zemel, Moran

    2016-06-01

    An agreement negotiated following a doctors' strike in 2011 introduced a requirement that physicians in Israel's public hospitals clock in and out when starting and leaving work. The press reported strong negative reactions to this policy and predicted doctors deserting hospitals en masse. This study examines physicians' reactions toward the clock-in/clock-out policy 6 months after its implementation, and assesses the relationship between these reactions and aspects of their employment context. 676 physicians in 42 hospitals responded to a survey assessing doctor's reactions toward the clock, hospital policy makers, and aspects of their work. Reactions to the clock were generally negative. Sense of calling correlated positively with negative reactions to the clock, and the latter correlated positively with quit intentions. However, overall, respondents reported a high sense of calling and low quit intentions. We suggest that sense of calling buffers and protects physicians from quit intentions. Differences in reactions to the clock were associated with different employment characteristics, but sense of calling did not vary by hospital size or type or by physicians' specialty. The findings offer insights into how physicians' working environment affects their reactions to regulatory interventions, and highlight medical professionalism as buffering reactions to unpopular regulatory policies. PMID:27142179

  14. The molecular clock as a metabolic rheostat.

    Science.gov (United States)

    Perelis, M; Ramsey, K M; Bass, J

    2015-09-01

    Circadian clocks are biologic oscillators present in all photosensitive species that produce 24-h cycles in the transcription of rate-limiting metabolic enzymes in anticipation of the light-dark cycle. In mammals, the clock drives energetic cycles to maintain physiologic constancy during the daily switch in behavioural (sleep/wake) and nutritional (fasting/feeding) states. A molecular connection between circadian clocks and tissue metabolism was first established with the discovery that 24-h transcriptional rhythms are cell-autonomous and self-sustained in most tissues and comprise a robust temporal network throughout the body. A major window in understanding how the clock is coupled to metabolism was opened with discovery of metabolic syndrome pathologies in multi-tissue circadian mutant mice including susceptibility to diet-induced obesity and diabetes. Using conditional transgenesis and dynamic metabolic testing, we have pinpointed tissue-specific roles of the clock in energy and glucose homeostasis, with our most detailed understanding of this process in endocrine pancreas. Here, we review evidence for dynamic regulation of insulin secretion and oxidative metabolic functions by the clock transcription pathway to regulate homeostatic responses to feeding and fasting. These studies indicate that clock transcription is a determinant of tissue function and provide a reference for understanding molecular pathologies linking circadian desynchrony to metabolic disease.

  15. Developing an "atomic clock" for fission lifetime measurements

    NARCIS (Netherlands)

    Wilschut, H.W.E.M.; Kravchuk, V.

    2004-01-01

    The relevance of measuring fission lifetimes of hot nuclei is briefly discussed. It is shown that K X-ray emission prior to fission can be used to measure fission lifetimes. The preparation of the K-shell hole, the simultaneous nuclear excitation, and the analysis of the X-ray spectra is described.

  16. Initial Tests of a Rubidium Space Cold Atom Clock

    Science.gov (United States)

    Lin, Li; Qiu-Zhi, Qu; Bin, Wang; Tang, Li; Jian-Bo, Zhao; Jing-Wei, Ji; Wei, Ren; Xin, Zhao; Mei-Feng, Ye; Yuan-Yuan, Yao; De-Sheng, Lü; Liang, Liu

    2016-06-01

    Not Available Supported by the National Key Scientific Instrument and Equipment Development Project of China under Grant No 2013YQ09094304, the Youth Innovation Promotion Association of Chinese Academy of Sciences, and the National Natural Science Foundation of China under Grant Nos 11034008 and 11274324.

  17. From Sundials to Atomic Clocks: Understanding Time and Frequency.

    Science.gov (United States)

    Jespersen, James; Fitz-Randolph, Jane

    An introduction to time, timekeeping, and the uses of time information, especially in the scientific and technical areas, are offered in this book for laymen. Historical and philosophical aspects of time and timekeeping are included. The scientific thought on time has been simplified. Contents include: the nature of time, time and frequency, early…

  18. Light clocks in strong gravitational fields

    CERN Document Server

    Punzi, Raffaele; Wohlfarth, Mattias N R

    2009-01-01

    We argue that the time measured by a light clock operating with photons rather than classical light requires a refinement of the standard clock postulate in general relativity. In the presence of a gravitational field, already the one-loop quantum corrections to classical Maxwell theory affect light propagation and the construction of observers' frames of reference. Carefully taking into account these kinematic effects, a concise geometric expression for the time shown by a light clock is obtained. This result has far-reaching implications for physics in strong gravitational fields.

  19. Transcripts from the Circadian Clock: Telling Time and Season

    NARCIS (Netherlands)

    K. Brand (Karl)

    2011-01-01

    textabstractWe all know it when we wake mere moments before an alarm clock is scheduled to wake us: our body clock made the alarm clock redundant. This phenomenon is driven by an endogenous timer known as the biological, or circadian clock. Each revolution of the Earth about its own axis produces pe

  20. Circadian and Circalunar Clock Interactions in a Marine Annelid

    Directory of Open Access Journals (Sweden)

    Juliane Zantke

    2013-10-01

    Full Text Available Life is controlled by multiple rhythms. Although the interaction of the daily (circadian clock with environmental stimuli, such as light, is well documented, its relationship to endogenous clocks with other periods is little understood. We establish that the marine worm Platynereis dumerilii possesses endogenous circadian and circalunar (monthly clocks and characterize their interactions. The RNAs of likely core circadian oscillator genes localize to a distinct nucleus of the worm’s forebrain. The worm’s forebrain also harbors a circalunar clock entrained by nocturnal light. This monthly clock regulates maturation and persists even when circadian clock oscillations are disrupted by the inhibition of casein kinase 1δ/ε. Both circadian and circalunar clocks converge on the regulation of transcript levels. Furthermore, the circalunar clock changes the period and power of circadian behavior, although the period length of the daily transcriptional oscillations remains unaltered. We conclude that a second endogenous noncircadian clock can influence circadian clock function.

  1. Gravitational Wave Detection with Single-Laser Atom Interferometers

    Science.gov (United States)

    Yu, Nan; Tinto, Massimo

    2011-01-01

    A new design for a broadband detector of gravitational radiation relies on two atom interferometers separated by a distance L. In this scheme, only one arm and one laser are used for operating the two atom interferometers. The innovation here involves the fact that the atoms in the atom interferometers are not only considered as perfect test masses, but also as highly stable clocks. Atomic coherence is intrinsically stable, and can be many orders of magnitude more stable than a laser.

  2. Micro Mercury Ion Clock (MMIC) Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Demonstrate micro clock based on trapped Hg ions with more than 10x size reduction and power; Fractional frequency stability at parts per 1014 level, adequate for...

  3. The Mechanics of Mechanical Watches and Clocks

    CERN Document Server

    Du, Ruxu

    2013-01-01

    "The Mechanics of Mechanical Watches and Clocks" presents historical views and mathematical models of mechanical watches and clocks. Although now over six hundred years old, mechanical watches and clocks are still popular luxury items that fascinate many people around the world. However few have examined the theory of how they work as presented in this book. The illustrations and computer animations are unique and have never been published before. It will be of significant interest to researchers in mechanical engineering, watchmakers and clockmakers, as well as people who have an engineering background and are interested in mechanical watches and clocks. It will also inspire people in other fields of science and technology, such as mechanical engineering and electronics engineering, to advance their designs. Professor Ruxu Du works at the Chinese University of Hong Kong, China. Assistant Professor Longhan Xie works at the South China University of Technology, China.

  4. Programmable Clock Waveform Generation for CCD Readout

    Energy Technology Data Exchange (ETDEWEB)

    Vicente, J. de; Castilla, J.; Martinez, G.; Marin, J.

    2006-07-01

    Charge transfer efficiency in CCDs is closely related to the clock waveform. In this paper, an experimental framework to explore different FPGA based clock waveform generator designs is described. Two alternative design approaches for controlling the rise/fall edge times and pulse width of the CCD clock signal have been implemented: level-control and time-control. Both approaches provide similar characteristics regarding the edge linearity and noise. Nevertheless, dissimilarities have been found with respect to the area and frequency range of application. Thus, while the time-control approach consumes less area, the level control approach provides a wider range of clock frequencies since it does not suffer capacitor discharge effect. (Author) 8 refs.

  5. Entrainment of the Neurospora circadian clock

    NARCIS (Netherlands)

    Merrow, M; Boesl, C; Ricken, J; Messerschmitt, M; Goedel, M; Roenneberg, T

    2006-01-01

    Neurospora crassa has been systematically investigated for circadian entrainment behavior. Many aspects of synchronization can be investigated in this simple, cellular system, ranging from systematic entrainment and drivenness to masking. Clock gene expression during entrainment and entrainment with

  6. Working around the clock: circadian rhythms and skeletal muscle

    OpenAIRE

    ZHANG, XIPING; Dube, Thomas J.; Esser, Karyn A.

    2009-01-01

    The study of the circadian molecular clock in skeletal muscle is in the very early stages. Initial research has demonstrated the presence of the molecular clock in skeletal muscle and that skeletal muscle of a clock-compromised mouse, Clock mutant, exhibits significant disruption in normal expression of many genes required for adult muscle structure and metabolism. In light of the growing association between the molecular clock, metabolism, and metabolic disease, it will also be important to ...

  7. Reduced Kalman Filters for Clock Ensembles

    Science.gov (United States)

    Greenhall, Charles A.

    2011-01-01

    This paper summarizes the author's work ontimescales based on Kalman filters that act upon the clock comparisons. The natural Kalman timescale algorithm tends to optimize long-term timescale stability at the expense of short-term stability. By subjecting each post-measurement error covariance matrix to a non-transparent reduction operation, one obtains corrected clocks with improved short-term stability and little sacrifice of long-term stability.

  8. Circadian clock proteins in mood regulation

    Directory of Open Access Journals (Sweden)

    Timo ePartonen

    2015-01-01

    Full Text Available Mood regulation is known to be affected by the change of seasons. Recent research findings have suggested that mood regulation may be influenced by the function of circadian clocks. In addition, the activity of brown adipocytes has been hypothesized to contribute to mood regulation. Here, the overarching link to mood disorders might be the circadian clock protein NR1D1 (nuclear receptor subfamily 1, group D, member 1.

  9. Investigations of laser pumped gas cell atomic frequency standard

    Science.gov (United States)

    Volk, C. H.; Camparo, J. C.; Fueholz, R. P.

    1982-01-01

    The performance characteristics of a rubidium gas cell atomic frequency standard might be improved by replacing the standard rubidium discharge lamp with a single mode laser diode. Aspects of the laser pumped gas cell atomic clock studied include effects due to laser intensity, laser detuning, and the choice of the particular atomic absorption line. Results indicate that the performance of the gas cell clock may be improved by judicious choice of the operating parameters of the laser diode. The laser diode also proved to be a valuable tool in investigating the operation of the conventional gas cell clock. Results concerning linewidths, the light shift effect and the effect of isotopic spin exchange in the conventional gas cell clock are reported.

  10. Adipose Clocks: Burning the Midnight Oil.

    Science.gov (United States)

    Henriksson, Emma; Lamia, Katja A

    2015-10-01

    Circadian clocks optimize the timing of physiological processes in synchrony with daily recurring and therefore predictable changes in the environment. Until the late 1990s, circadian clocks were thought to exist only in the central nervous systems of animals; elegant studies in cultured fibroblasts and using genetically encoded reporters in Drosophila melanogaster and in mice showed that clocks are ubiquitous and cell autonomous. These findings inspired investigations of the advantages construed by enabling each organ to independently adjust its function to the time of day. Studies of rhythmic gene expression in several organs suggested that peripheral organ clocks might play an important role in optimizing metabolic physiology by synchronizing tissue-intrinsic metabolic processes to cycles of nutrient availability and energy requirements. The effects of clock disruption in liver, pancreas, muscle, and adipose tissues support that hypothesis. Adipose tissues coordinate energy storage and utilization and modulate behavior and the physiology of other organs by secreting hormones known as "adipokines." Due to behavior- and environment-driven diurnal variations in supply and demand for chemical and thermal energy, adipose tissues might represent an important peripheral location for coordinating circadian energy balance (intake, storage, and utilization) over the whole organism. Given the complexity of adipose cell types and depots, the sensitivity of adipose tissue biology to age and diet composition, and the plethora of known and yet-to-be-discovered adipokines and lipokines, we have just begun to scratch the surface of understanding the role of circadian clocks in adipose tissues.

  11. The Chemical and Educational Appeal of the Orange Juice Clock

    Science.gov (United States)

    Kelter, Paul B.; Carr, James D.; Johnson, Tanya; Mauricio Castro-Acuña, Carlos

    1996-12-01

    characterized by seeing educational possibilities in so many things, created a modified version of the clock, with the atomic numbers of the elements representing the hours in the day (see Fig. 2) in his internationally popular workshops. Due largely to Talesnick's efforts, the orange juice clock is a standard demonstration in many chemistry programs and presentations. Figure 2.Irwin Talesnick represents the hours of the day by the corresponding elements in his clock. The Procedure This can be done as a demonstration or as an activity, although at about 10 per clock, expense does become an issue. There are no unusual safety precautions with this demonstration. We know of no accidents that have occurred with the orange juice clock. The demonstration requires: a single AA-cell battery-operated wall clock with a sweep-second hand a medium-sized beaker (600 mL is fine) enough orange juice or other electrolyte mixture or solution to fill the beaker about 2/3 full (tap water often works fine!) a 20-30-cm magnesium strip, coiled at one end or wrapped around a popsicle stick a 20-30-cm copper strip, coiled at one end alligator clips to connect the strips to the battery terminals on the clock a stand against which to lean the setup The demonstration is put together as shown in Figure 3. Connect the magnesium to the "-" contact of the clock and the copper to the "+" contact. Immerse the other ends of the strips into the solution. The clock will start to tick within a few seconds. If it does not work within a short period of time, check that the strips are well connected to the battery terminals, are hooked to the proper poles, and are not touching each other. The clock should keep reasonably close time (in orange juice) for a couple of days, or until the magnesium is nearly completely oxidized. Figure 3.A schematic of the orange juice clock seup. Video of orange juice clock. In video, the copper electrode is on the left and the magnesium electrode is on the right. Video was filmed and

  12. Helium Pressure Shift of the Hyperfine Clock Transition in Hg-201(+)

    Science.gov (United States)

    Larigani, S. Taghavi; Burt, E. A.; Tjoelker, R. L.

    2010-01-01

    There are two stable odd isotopes of mercury with singly ionized hyperfine structure suitable for a microwave atomic clock: Hg-199(+) and Hg-201(+). We are investigating the viability of a trapped ion clock based on Hg-201(+) in a configuration that uses a buffer gas to increase ion loading efficiency and counter ion heating from rf trapping fields. Traditionally, either helium or neon is used as the buffer gas at approx. 10(exp -5) torr to confine mercury ions near room temperature. In addition to the buffer gas, other residual background gasses such as H2O, N2, O2, CO, CO2, and CH2 may be present in trace quantities. Collisions between trapped ions and buffer gas or background gas atoms/molecules produce a momentary shift of the ion clock transition frequency and constitute one of the largest systematic effects in this type of clock. Here we report an initial measurement of the He pressure shift in Hg-201(+) and compare this to Hg-199(+).

  13. Analysis of the blackbody-radiation shift in an ytterbium optical lattice clock

    Science.gov (United States)

    Xu, Yi-Lin; Xu, Xin-Ye

    2016-10-01

    We accurately evaluate the blackbody-radiation shift in a 171Yb optical lattice clock by utilizing temperature measurement and numerical simulation. In this work. three main radiation sources are considered for the blackbody-radiation shift, including the heated atomic oven, the warm vacuum chamber, and the room-temperature vacuum windows. The temperatures on the outer surface of the vacuum chamber are measured during the clock operation period by utilizing seven calibrated temperature sensors. Then we infer the temperature distribution inside the vacuum chamber by numerical simulation according to the measured temperatures. Furthermore, we simulate the temperature variation around the cold atoms while the environmental temperature is fluctuating. Finally, we obtain that the total blackbody-radiation shift is -1.289(7) Hz with an uncertainty of 1.25 × 10-17 for our 171Yb optical lattice clock. The presented method is quite suitable for accurately evaluating the blackbody-radiation shift of the optical lattice clock in the case of lacking the sensors inside the vacuum chamber. Project supported by the National Key Basic Research and Development Program of China (Grant No. 2012CB821302), the National Natural Science Foundation of China (Grant No. 11134003), the National High Technology Research and Development Program of China (Grant No. 2014AA123401), and the Shanghai Excellent Academic Leaders Program of China (Grant No. 12XD1402400).

  14. Interaction of circadian clock proteins PER2 and CRY with BMAL1 and CLOCK

    Directory of Open Access Journals (Sweden)

    Bordon Alain

    2008-04-01

    Full Text Available Abstract Background Circadian oscillation of clock-controlled gene expression is mainly regulated at the transcriptional level. Heterodimers of CLOCK and BMAL1 act as activators of target gene transcription; however, interactions of PER and CRY proteins with the heterodimer abolish its transcriptional activation capacity. PER and CRY are therefore referred to as negative regulators of the circadian clock. To further elucidate the mechanism how positive and negative components of the clock interplay, we characterized the interactions of PER2, CRY1 and CRY2 with BMAL1 and CLOCK using a mammalian two-hybrid system and co-immunoprecipitation assays. Results Both PER2 and the CRY proteins were found to interact with BMAL1 whereas only PER2 interacts with CLOCK. CRY proteins seem to have a higher affinity to BMAL1 than PER2. Moreover, we provide evidence that PER2, CRY1 and CRY2 bind to different domains in the BMAL1 protein. Conclusion The regulators of clock-controlled transcription PER2, CRY1 and CRY2 differ in their capacity to interact with each single component of the BMAL1-CLOCK heterodimer and, in the case of BMAL1, also in their interaction sites. Our data supports the hypothesis that CRY proteins, especially CRY1, are stronger repressors than PER proteins.

  15. Gated Clock Implementation of Arithmetic Logic Unit (ALU

    Directory of Open Access Journals (Sweden)

    Dr. Neelam R. Prakash

    2013-05-01

    Full Text Available Low power design has emerged as one of the challenging area in today’s ASIC (Application specific integrated circuit design. With continuous decrease in transistor size, power density is increasing and there is an urgent need for reduction in total power consumption. Clock gating is one most effective technique for low power synchronous circuit design. Clock gating technique in low power design is used to reduce the dynamic power consumption. Clock signal in a synchronous circuit is used for synchronization only and hence does not carry any important information. Since clock is applied to each block of a synchronous circuit, and clock switches for every cycle, clock power is the major part of dynamic power consumption in synchronous circuits. Clock gating is a well known technique to reduce clock power. In clock gating clock to an idle block is disabled. Thus significant amount of power consumption is reduced by employing clock gating. In this paper an ALU design is proposed employing Gated clock for its operation. Design simulation has been performed on Xilinx ISE design suite, and power calculation is done by Xilinx Xpower analyzer. Results show that approximately 17% of total clock power consumption is reduced by gated clock implementation.

  16. DESIGN OF TWO-PHASE SINUSOIDAL POWER CLOCK AND CLOCKED TRANSMISSION GATE ADIABATIC LOGIC CIRCUIT

    Institute of Scientific and Technical Information of China (English)

    Wang Pengjun; Yu Junjun

    2007-01-01

    First the research is conducted on the design of the two-phase sinusoidal power clock generator in this paper. Then the design of the new adiabatic logic circuit adopting the two-phase sinusoidal power clocks-Clocked Transmission Gate Adiabatic Logic (CTGAL) circuit is presented. This circuit makes use of the clocked transmission gates to sample the input signals, then the output loads are charged and discharged in a fully adiabatic manner by using bootstrapped N-Channel Metal Oxide Semiconductor (NMOS) and Complementary Metal Oxide Semiconductor (CMOS) latch structure.Finally, with the parameters of Taiwan Semiconductor Manufacturing Company (TSMC) 0.25 μm CMOS device, the transient energy consumption of CTGAL, Bootstrap Charge-Recovery Logic (BCRL)and Pass-transistor Adiabatic Logic (PAL) including their clock generators is simulated. The simulation result indicates that CTGAL circuit has the characteristic of remarkably low energy consumption.

  17. Al+ Optical Clocks for Fundamental Physics and Geodesy

    Energy Technology Data Exchange (ETDEWEB)

    Chou, James Chin-wen (Ion Storage Group, NIST)

    2011-07-13

    Laser-cooled trapped atoms have long been recognized as potentially very accurate frequency standards for clocks. Ultimate accuracies of 10-18 to 10-19 appear possible, limited by the time-dilation of trapped ions that move at laser-cooled velocities. The Al+ ion is an attractive candidate for high accuracy, owing to its narrow electronic transition in the optical regime and low sensitivity to ambient field perturbations. Precision spectroscopy on Al+ is enabled by quantum information techniques. With Al+ “quantum-logic” clocks, the current accuracy of 8.6×10-18 has enabled a geo-potential-difference measurement that detected a height change of 37±17 cm due to the gravitational red-shift. We have also observed quantum coherence between two Al+ ions with a record Q-factor of 3.4×1016, and compared the Al+ resonance frequency to that of a single Hg+ ion to place limits on the temporal variation of the fine-structure constant.

  18. Direct laser cooling Al+ ions optical clocks

    CERN Document Server

    Zhang, J; Luo, J; Lu, Z H

    2016-01-01

    Al$^+$ ions optical clock is a very promising optical frequency standard candidate due to its extremely small blackbody radiation shift. It has been successfully demonstrated with indirect cooled, quantum-logic-based spectroscopy technique. Its accuracy is limited by second-order Doppler shift, and its stability is limited by the number of ions that can be probed in quantum logic processing. We propose a direct laser cooling scheme of Al$^+$ ions optical clocks where both the stability and accuracy of the clocks are greatly improved. In the proposed scheme, two Al$^+$ ions traps are utilized. The first trap is used to trap a large number of Al$^+$ ions to improve the stability of the clock laser, while the second trap is used to trap a single Al$^+$ ions to provide the ultimate accuracy. Both traps are cooled with a continuous wave 167 nm laser. The expected clock laser stability can reach $9.0\\times10^{-17}/\\sqrt{\\tau}$. For the second trap, in addition to 167 nm laser Doppler cooling, a second stage pulsed ...

  19. A New Navigation Satellite Clock Bias Prediction Method Based on Modified Clock-bias Quadratic Polynomial Model

    Science.gov (United States)

    Wang, Y. P.; Lu, Z. P.; Sun, D. S.; Wang, N.

    2016-01-01

    In order to better express the characteristics of satellite clock bias (SCB) and improve SCB prediction precision, this paper proposed a new SCB prediction model which can take physical characteristics of space-borne atomic clock, the cyclic variation, and random part of SCB into consideration. First, the new model employs a quadratic polynomial model with periodic items to fit and extract the trend term and cyclic term of SCB; then based on the characteristics of fitting residuals, a time series ARIMA ~(Auto-Regressive Integrated Moving Average) model is used to model the residuals; eventually, the results from the two models are combined to obtain final SCB prediction values. At last, this paper uses precise SCB data from IGS (International GNSS Service) to conduct prediction tests, and the results show that the proposed model is effective and has better prediction performance compared with the quadratic polynomial model, grey model, and ARIMA model. In addition, the new method can also overcome the insufficiency of the ARIMA model in model recognition and order determination.

  20. Quantum clock: A critical discussion on spacetime

    CERN Document Server

    Burderi, Luciano; Iaria, Rosario

    2016-01-01

    We critically discuss the measure of very short time intervals. By means of a Gedankenexperiment, we describe an ideal clock based on the occurrence of completely random events. Many previous thought experiments have suggested fundamental Planck-scale limits on measurements of distance and time. Here we present a new type of thought experiment, based on a different type of clock, that provide further support for the existence of such limits. We show that the minimum time interval $\\Delta t$ that this clock can measure scales as the inverse of its size $\\Delta r$. This implies an uncertainty relation between space and time: $\\Delta r$ $\\Delta t$ $> G \\hbar / c^4$; where G, $\\hbar$ and c are the gravitational constant, the reduced Planck constant, and the speed of light, respectively. We outline and briefly discuss the implications of this uncertainty conjecture.

  1. Models of the Primordial Standard Clock

    CERN Document Server

    Chen, Xingang; Wang, Yi

    2014-01-01

    Oscillating massive fields in the primordial universe can be used as Standard Clocks. The ticks of these oscillations induce features in the density perturbations, which directly record the time evolution of the scale factor of the primordial universe, thus if detected, provide a direct evidence for the inflation scenario or the alternatives. In this paper, we construct a full inflationary model of primordial Standard Clock and study its predictions on the density perturbations. This model provides a full realization of several key features proposed previously. We compare the theoretical predictions from inflation and alternative scenarios with the Planck 2013 temperature data on Cosmic Microwave Background (CMB), and identify a statistically marginal but interesting candidate. We discuss how future CMB temperature and polarization data, non-Gaussianity analysis and Large Scale Structure data may be used to further test or constrain the Standard Clock signals.

  2. Circadian clock: linking epigenetics to aging.

    Science.gov (United States)

    Orozco-Solis, Ricardo; Sassone-Corsi, Paolo

    2014-06-01

    Circadian rhythms are generated by an intrinsic cellular mechanism that controls a large array of physiological and metabolic processes. There is erosion in the robustness of circadian rhythms during aging, and disruption of the clock by genetic ablation of specific genes is associated with aging-related features. Importantly, environmental conditions are thought to modulate the aging process. For example, caloric restriction is a very strong environmental effector capable of delaying aging. Intracellular pathways implicating nutrient sensors, such as SIRTs and mTOR complexes, impinge on cellular and epigenetic mechanisms that control the aging process. Strikingly, accumulating evidences indicate that these pathways are involved in both the modulation of the aging process and the control of the clock. Hence, innovative therapeutic strategies focused at controlling the circadian clock and the nutrient sensing pathways might beneficially influence the negative effects of aging. PMID:25033025

  3. Biogeographic calibrations for the molecular clock.

    Science.gov (United States)

    Ho, Simon Y W; Tong, K Jun; Foster, Charles S P; Ritchie, Andrew M; Lo, Nathan; Crisp, Michael D

    2015-09-01

    Molecular estimates of evolutionary timescales have an important role in a range of biological studies. Such estimates can be made using methods based on molecular clocks, including models that are able to account for rate variation across lineages. All clock models share a dependence on calibrations, which enable estimates to be given in absolute time units. There are many available methods for incorporating fossil calibrations, but geological and climatic data can also provide useful calibrations for molecular clocks. However, a number of strong assumptions need to be made when using these biogeographic calibrations, leading to wide variation in their reliability and precision. In this review, we describe the nature of biogeographic calibrations and the assumptions that they involve. We present an overview of the different geological and climatic events that can provide informative calibrations, and explain how such temporal information can be incorporated into dating analyses.

  4. Sample-Clock Phase-Control Feedback

    Science.gov (United States)

    Quirk, Kevin J.; Gin, Jonathan W.; Nguyen, Danh H.; Nguyen, Huy

    2012-01-01

    To demodulate a communication signal, a receiver must recover and synchronize to the symbol timing of a received waveform. In a system that utilizes digital sampling, the fidelity of synchronization is limited by the time between the symbol boundary and closest sample time location. To reduce this error, one typically uses a sample clock in excess of the symbol rate in order to provide multiple samples per symbol, thereby lowering the error limit to a fraction of a symbol time. For systems with a large modulation bandwidth, the required sample clock rate is prohibitive due to current technological barriers and processing complexity. With precise control of the phase of the sample clock, one can sample the received signal at times arbitrarily close to the symbol boundary, thus obviating the need, from a synchronization perspective, for multiple samples per symbol. Sample-clock phase-control feedback was developed for use in the demodulation of an optical communication signal, where multi-GHz modulation bandwidths would require prohibitively large sample clock frequencies for rates in excess of the symbol rate. A custom mixedsignal (RF/digital) offset phase-locked loop circuit was developed to control the phase of the 6.4-GHz clock that samples the photon-counting detector output. The offset phase-locked loop is driven by a feedback mechanism that continuously corrects for variation in the symbol time due to motion between the transmitter and receiver as well as oscillator instability. This innovation will allow significant improvements in receiver throughput; for example, the throughput of a pulse-position modulation (PPM) with 16 slots can increase from 188 Mb/s to 1.5 Gb/s.

  5. Ionization and transient absorption control with a resonant attosecond clock

    International Nuclear Information System (INIS)

    Metastable states are important actors in the ionisation of atoms and molecules. Sub-femtosecond extreme ultraviolet pulses can coherently populate several transiently bound states at once, thus starting the attosecond clocks which are required to monitor and control ultrafast electronic evolution above the ionisation threshold. Here we illustrate, from a theoretical point of view, the effects coherent superpositions of 1Po doubly excited states in the helium atom have on channel-resolved photoelectron spectra as well as on the transient absorption spectrum of the atom in the extreme ultraviolet region, when they are created by a single-attosecond pulse in the presence of a strong few-cycle near-infrared/visible pulse which acts as a probe. Interference fringes varying rapidly with the pump-probe time delay are visible in both photoelectron and transient absorption spectra. From such fringes, the wave packet itself can conceivably be reconstructed. Conversely, all observables are modulated by the characteristic beating periods of the wave packet, so that control of partial ionisation yields, branching ratios, and light absorption or amplification can be achieved

  6. NIM5 Cs fountain clock and its evaluation

    Science.gov (United States)

    Fang, Fang; Li, Mingshou; Lin, Pingwei; Chen, Weiliang; Liu, Nianfeng; Lin, Yige; Wang, Ping; Liu, Kun; Suo, Rui; Li, Tianchu

    2015-08-01

    The cesium fountain primary frequency standard NIM5 has been developed at the National Institute of Metrology in China. The NIM5 loads atoms in an optical molasses from the background Cs vapor directly. Atoms are then cooled to a temperature of about 2 μK and launched to a height of 81 cm. The fringes of the Ramsey pattern have a width of 0.98 Hz. The NIM5 operates for more than 300 d a year, operating nearly continuously for 15 d at a time. By stabilizing the 9.19 GHz microwave frequency to the center of the central Ramsey fringe, a typical fractional frequency instability of 3 × 10-13 (τ/s)-1/2 is obtained when running at high atom density, and a combined uncertainty, including Type A and B uncertainties, is typically 1.6 × 10-15. Comparisons of data between NIM5 and 5 other fountain clocks were carried out in May 2013 via two-way satellite time and frequency transfer (TWSTFT), and the results show good agreement within the uncertainties. Six groups of NIM5 data from January to June 2014 have been published in Circular T 319 and 320.

  7. Water-Powered Astronomical Clock Tower

    Science.gov (United States)

    Sun, Xiaochun

    The construction of water-powered astronomical instruments was a long tradition of instrument making that started in the second century AD with Zhang Heng's water-powered celestial globe. The technology reached a peak when, in the eleventh century, Su Song and his team constructed the Water-Powered Astronomical Clock Tower which combined the armillary sphere, the celestial globe, and the time-keeping mechanism into a large automatic structure. Su Song's instrument contained a mechanism for controlling the water-powered movements of its wheels that amounts to an "escapement mechanism" for a mechanical clock. A new reconstruction of the mechanism is introduced in this chapter.

  8. Clocking Scheme for Switched-Capacitor Circuits

    DEFF Research Database (Denmark)

    Steensgaard-Madsen, Jesper

    1998-01-01

    A novel clocking scheme for switched-capacitor (SC) circuits is presented. It can enhance the understanding of SC circuits and the errors caused by MOSFET (MOS) switches. Charge errors, and techniques to make SC circuits less sensitive to them are discussed.......A novel clocking scheme for switched-capacitor (SC) circuits is presented. It can enhance the understanding of SC circuits and the errors caused by MOSFET (MOS) switches. Charge errors, and techniques to make SC circuits less sensitive to them are discussed....

  9. Using GLONASS signal for clock synchronization

    Science.gov (United States)

    Gouzhva, Yuri G.; Gevorkyan, Arvid G.; Bogdanov, Pyotr P.; Ovchinnikov, Vitaly V.

    1994-01-01

    Although in accuracy parameters GLONASS is correlated with GPS, using GLONASS signals for high-precision clock synchronization was, up to the recent time, of limited utility due to the lack of specialized time receivers. In order to improve this situation, in late 1992 the Russian Institute of Radionavigation and Time (RMT) began to develop a GLONASS time receiver using as a basis the airborne ASN-16 receiver. This paper presents results of estimating user clock synchronization accuracy via GLONASS signals using ASN-16 receiver in the direct synchronization and common-view modes.

  10. Secure and self-stabilizing clock synchronization in sensor networks

    NARCIS (Netherlands)

    Hoepman, J.H.; Larsson, A.; Schiller, E.M.; Tsigas, P.

    2007-01-01

    In sensor networks, correct clocks have arbitrary starting offsets and nondeterministic fluctuating skews. We consider an adversary that aims at tampering with the clock synchronization by intercepting messages, replaying intercepted messages (after the adversary's choice of delay), and capturing no

  11. Navstar Global Positioning System (GPS) clock program: Present and future

    Science.gov (United States)

    Tennant, D. M.

    1981-01-01

    Global Positioning System (GPS) program status are discussed and plans for ensuring the long term continuation of the program are presented. Performance of GPS clocks is presented in terms of on orbit data as portrayed by GPS master control station kalman filter processing. The GPS Clock reliability program is reviewed in depth and future plans fo the overall clock program are published.

  12. Determination of the thermal radiation effect on an optical strontium lattice clock; Bestimmung des Einflusses thermischer Strahlung auf eine optische Strontium-Gitteruhr

    Energy Technology Data Exchange (ETDEWEB)

    Middelmann, Thomas

    2013-05-31

    Optical clocks have the potential to be 100 times more accurate than current best cesium atomic clocks within a fraction of the averaging time. This corresponds to a fractional uncertainty of the clock frequency on the level of 10{sup -18} and requires highaccuracy knowledge of systematic frequency shifts, such that they can be avoided or corrected for. In strontium optical lattice clocks an ensemble of ultracold strontium atoms is confined in an optical lattice, to allow for spectroscopy of the reference transition 5s{sup 2} {sup 1}S{sub 0}-5s5p {sup 3}P{sub 0} in the Lamb-Dicke regime. The by far largest systematic frequency shift of the strontium clock transition is caused by its high sensitivity to blackbody radiation (BBR). The knowledge of the resulting frequency shift limited the achievable clock uncertainty to about 1 x 10{sup -16}. In this thesis for the first time an experimental approach was followed, to determine the sensitivity of the strontium clock transition to blackbody radiation. At an environmental temperature of 300 K the resulting frequency shift corresponds to 2.277 8(23) Hz. The achieved uncertainty contributes with 5 x 10{sup -18} to the fractional systematic uncertainty of the clock frequency. The determination is based on a precision measurement of the difference of static polarizabilities of the two clock states {Delta}{alpha}{sub dc} = {alpha}(5s5p {sup 3}P{sub 0})-{alpha}(5s{sup 2} {sup 1}S{sub 0}) = 4.078 73(11) x 10{sup -39} Cm{sup 2} /V. For this the de Stark shift of the clock transition has been measured in the accurately known electric field of a precision plate capacitor, which has been developed in this work. The attained static polarizability difference {Delta}{alpha}{sub dc} corresponds to the first term of a power series of the sensitivity to BBR. Higher orders are accumulated as dynamic part of the BBR shift. Which has been modelled using {Delta}{alpha}{sub dc} and experimental data for other atomic properties. To

  13. Clock Synchronization for Multihop Wireless Sensor Networks

    Science.gov (United States)

    Solis Robles, Roberto

    2009-01-01

    In wireless sensor networks, more so generally than in other types of distributed systems, clock synchronization is crucial since by having this service available, several applications such as media access protocols, object tracking, or data fusion, would improve their performance. In this dissertation, we propose a set of algorithms to achieve…

  14. Circadian Clock Regulates Bone Resorption in Mice.

    Science.gov (United States)

    Xu, Cheng; Ochi, Hiroki; Fukuda, Toru; Sato, Shingo; Sunamura, Satoko; Takarada, Takeshi; Hinoi, Eiichi; Okawa, Atsushi; Takeda, Shu

    2016-07-01

    The circadian clock controls many behavioral and physiological processes beyond daily rhythms. Circadian dysfunction increases the risk of cancer, obesity, and cardiovascular and metabolic diseases. Although clinical studies have shown that bone resorption is controlled by circadian rhythm, as indicated by diurnal variations in bone resorption, the molecular mechanism of circadian clock-dependent bone resorption remains unknown. To clarify the role of circadian rhythm in bone resorption, aryl hydrocarbon receptor nuclear translocator-like (Bmal1), a prototype circadian gene, was knocked out specifically in osteoclasts. Osteoclast-specific Bmal1-knockout mice showed a high bone mass phenotype due to reduced osteoclast differentiation. A cell-based assay revealed that BMAL1 upregulated nuclear factor of activated T cells, cytoplasmic, calcineurin-dependent 1 (Nfatc1) transcription through its binding to an E-box element located on the Nfatc1 promoter in cooperation with circadian locomotor output cycles kaput (CLOCK), a heterodimer partner of BMAL1. Moreover, steroid receptor coactivator (SRC) family members were shown to interact with and upregulate BMAL1:CLOCK transcriptional activity. Collectively, these data suggest that bone resorption is controlled by osteoclastic BMAL1 through interactions with the SRC family and binding to the Nfatc1 promoter. © 2016 American Society for Bone and Mineral Research. PMID:26841172

  15. An Iodine Fluorescence Quenching Clock Reaction

    Science.gov (United States)

    Weinberg, Richard B.; Muyskens, Mark

    2007-01-01

    Clock reactions based upon competing oxidation and reduction reactions of iodine and starch as the most popular type of chemistry example is presented to illustrate the redox phenomena, reaction kinetics, and principles of chemical titration. The examination of the photophysical principles underlying the iodine fluorescence quenching clock…

  16. The peripheral clock regulates human pigmentation.

    Science.gov (United States)

    Hardman, Jonathan A; Tobin, Desmond J; Haslam, Iain S; Farjo, Nilofer; Farjo, Bessam; Al-Nuaimi, Yusur; Grimaldi, Benedetto; Paus, Ralf

    2015-04-01

    Although the regulation of pigmentation is well characterized, it remains unclear whether cell-autonomous controls regulate the cyclic on-off switching of pigmentation in the hair follicle (HF). As human HFs and epidermal melanocytes express clock genes and proteins, and given that core clock genes (PER1, BMAL1) modulate human HF cycling, we investigated whether peripheral clock activity influences human HF pigmentation. We found that silencing BMAL1 or PER1 in human HFs increased HF melanin content. Furthermore, tyrosinase expression and activity, as well as TYRP1 and TYRP2 mRNA levels, gp100 protein expression, melanocyte dendricity, and the number gp100+ HF melanocytes, were all significantly increased in BMAL1 and/or PER1-silenced HFs. BMAL1 or PER1 silencing also increased epidermal melanin content, gp100 protein expression, and tyrosinase activity in human skin. These effects reflect direct modulation of melanocytes, as BMAL1 and/or PER1 silencing in isolated melanocytes increased tyrosinase activity and TYRP1/2 expression. Mechanistically, BMAL1 knockdown reduces PER1 transcription, and PER1 silencing induces phosphorylation of the master regulator of melanogenesis, microphthalmia-associated transcription factor, thus stimulating human melanogenesis and melanocyte activity in situ and in vitro. Therefore, the molecular clock operates as a cell-autonomous modulator of human pigmentation and may be targeted for future therapeutic strategies. PMID:25310406

  17. Analytic clock frequency selection for global DVFS

    NARCIS (Netherlands)

    Gerards, Marco E.T.; Hurink, Johann L.; Hölzenspies, Philip K.F.; Kuper, Jan; Smit, Gerard J.M.

    2014-01-01

    Computers can reduce their power consumption by decreasing their speed using Dynamic Voltage and Frequency Scaling (DVFS). A form of DVFS for multicore processors is global DVFS, where the voltage and clock frequency is shared among all processor cores. Because global DVFS is efficient and cheap to

  18. Current Status of the Molecular Clock Hypothesis

    Science.gov (United States)

    Hermann, Gilbert

    2003-01-01

    Molecular genetics is a rapidly changing field with new developments almost from day to day. One interesting hypothesis that has come from everyone's ability to sequence proteins and/or genes is that of the molecular clock. This hypothesis postulates that homologous sequences of DNA and thus macro molecules evolve at a constant and invariable rate…

  19. On accelerated clocks and the quantum theory

    International Nuclear Information System (INIS)

    It is shown that the locality hypothesis of relativity breaks down for large proper accelerations which are relevant to semiclassical phenomena. A general modification for the rate of accelerated clocks incorporating the effect of proper acceleration is thus proposed. Connection is made with Caianiello's quantum line element

  20. Light scattering from dense cold atomic media

    CERN Document Server

    Zhu, Bihui; Ye, Jun; Rey, Ana Maria

    2016-01-01

    We theoretically study the propagation of light through a cold atomic medium, where the effects of motion, laser intensity, atomic density, and polarization can all modify the properties of the scattered light. We present two different microscopic models: the "coherent dipole model" and the "random walk model", both suitable for modeling recent experimental work done in large atomic arrays in the low light intensity regime. We use them to compute relevant observables such as the linewidth, peak intensity and line center of the emitted light. We further develop generalized models that explicitly take into account atomic motion. Those are relevant for hotter atoms and beyond the low intensity regime. We show that atomic motion can lead to drastic dephasing and to a reduction of collective effects, together with a distortion of the lineshape. Our results are applicable to model a full gamut of quantum systems that rely on atom-light interactions including atomic clocks, quantum simulators and nanophotonic system...

  1. Maximum likelihood molecular clock comb: analytic solutions.

    Science.gov (United States)

    Chor, Benny; Khetan, Amit; Snir, Sagi

    2006-04-01

    Maximum likelihood (ML) is increasingly used as an optimality criterion for selecting evolutionary trees, but finding the global optimum is a hard computational task. Because no general analytic solution is known, numeric techniques such as hill climbing or expectation maximization (EM), are used in order to find optimal parameters for a given tree. So far, analytic solutions were derived only for the simplest model--three taxa, two state characters, under a molecular clock. Four taxa rooted trees have two topologies--the fork (two subtrees with two leaves each) and the comb (one subtree with three leaves, the other with a single leaf). In a previous work, we devised a closed form analytic solution for the ML molecular clock fork. In this work, we extend the state of the art in the area of analytic solutions ML trees to the family of all four taxa trees under the molecular clock assumption. The change from the fork topology to the comb incurs a major increase in the complexity of the underlying algebraic system and requires novel techniques and approaches. We combine the ultrametric properties of molecular clock trees with the Hadamard conjugation to derive a number of topology dependent identities. Employing these identities, we substantially simplify the system of polynomial equations. We finally use tools from algebraic geometry (e.g., Gröbner bases, ideal saturation, resultants) and employ symbolic algebra software to obtain analytic solutions for the comb. We show that in contrast to the fork, the comb has no closed form solutions (expressed by radicals in the input data). In general, four taxa trees can have multiple ML points. In contrast, we can now prove that under the molecular clock assumption, the comb has a unique (local and global) ML point. (Such uniqueness was previously shown for the fork.).

  2. Suppression of clock shifts at field-insensitive transitions

    CERN Document Server

    Arnold, Kyle J

    2016-01-01

    We show that it is possible to significantly reduce quadrupole and tensor polarizability shifts of a clock transition by operating at a judiciously chosen field-insensitive point. In some cases shifts are almost completely eliminated making the transition an effective J = 0 to J = 0 candidate. This significantly improves the feasibility of a recent proposal for clock operation with large ion crystals. For such multi-ion clocks, geometric constraints and selection rules naturally divide clock operation into two categories based on the orientation of the magnetic field. We discuss the limitations imposed on each type and how calibrations might be carried out for clock operation.

  3. Study on the Distribution of Networked Devices’ Clock Skew

    Directory of Open Access Journals (Sweden)

    Jiao Chengbo

    2011-08-01

    Full Text Available Clock skews of devices on the Internet are viewed as one way delay noise, but their distribution is unknown. We explore the distribution of clock skews to see the conflict probability. In this paper, we introduce an accurate clock skew estimation algorithm to filter inaccurate clock skew estimation by comparing the results between linear programming method and least square fitting. Delay jitter and other noises affect the estimation result. When the difference of two methods is large, the estimation result is unstable and inaccurate, so the estimation result should be dropped. Based on this algorithm, we use traces of real Internet measurements to collect 1825 accurate clock skews of different devices to establish a fingerprint database. Furthermore, we show the distribution of clock skews and comparing conflict probability with different number of devices. The distribution shows that clock skews are diverse, and most of clock skews are in the region of [-100, 100] PPM. The results indicate that when the number of devices is small (<5, clock skews won’t be conflict with each other, so clock skews are good tools to detect faked devices or NAT; When the number of devices increases, the conflict probability increases linearly, so clock skews of different devices can not distinguish each devices effectively.

  4. Molecular-clock methods for estimating evolutionary rates and timescales.

    Science.gov (United States)

    Ho, Simon Y W; Duchêne, Sebastián

    2014-12-01

    The molecular clock presents a means of estimating evolutionary rates and timescales using genetic data. These estimates can lead to important insights into evolutionary processes and mechanisms, as well as providing a framework for further biological analyses. To deal with rate variation among genes and among lineages, a diverse range of molecular-clock methods have been developed. These methods have been implemented in various software packages and differ in their statistical properties, ability to handle different models of rate variation, capacity to incorporate various forms of calibrating information and tractability for analysing large data sets. Choosing a suitable molecular-clock model can be a challenging exercise, but a number of model-selection techniques are available. In this review, we describe the different forms of evolutionary rate heterogeneity and explain how they can be accommodated in molecular-clock analyses. We provide an outline of the various clock methods and models that are available, including the strict clock, local clocks, discrete clocks and relaxed clocks. Techniques for calibration and clock-model selection are also described, along with methods for handling multilocus data sets. We conclude our review with some comments about the future of molecular clocks.

  5. The sympathy of two pendulum clocks: beyond Huygens’ observations

    Science.gov (United States)

    Peña Ramirez, Jonatan; Olvera, Luis Alberto; Nijmeijer, Henk; Alvarez, Joaquin

    2016-01-01

    This paper introduces a modern version of the classical Huygens’ experiment on synchronization of pendulum clocks. The version presented here consists of two monumental pendulum clocks—ad hoc designed and fabricated—which are coupled through a wooden structure. It is demonstrated that the coupled clocks exhibit ‘sympathetic’ motion, i.e. the pendula of the clocks oscillate in consonance and in the same direction. Interestingly, when the clocks are synchronized, the common oscillation frequency decreases, i.e. the clocks become slow and inaccurate. In order to rigorously explain these findings, a mathematical model for the coupled clocks is obtained by using well-established physical and mechanical laws and likewise, a theoretical analysis is conducted. Ultimately, the sympathy of two monumental pendulum clocks, interacting via a flexible coupling structure, is experimentally, numerically, and analytically demonstrated. PMID:27020903

  6. Comparison of Two Independent Sr Optical Clocks with 1*10^-17 Stability at 10^3 s

    CERN Document Server

    Nicholson, T L; Williams, J R; Bloom, B J; Bishof, M; Swallows, M D; Campbell, S L; Ye, J

    2012-01-01

    Many-particle optical lattice clocks have the potential for unprecedented measurement precision and stability due to their low quantum projection noise (QPN). However, this potential has so far never been realized because clock stability has been limited by frequency noise of optical local oscillators. By synchronously probing two 87Sr lattice systems using a laser with a thermal noise floor of 1*10^-15, we remove classically correlated laser noise from the inter-comparison, but this approach does not improve the stability of an independent clock. With an improved optical oscillator that has a 1*10^-16 thermal noise floor, we demonstrate an order of magnitude improvement over the best reported independent clock stability, achieving a record fractional instability of 1*10^-17 in 1000 s of averaging time for synchronous or asynchronous comparisons. This result is within a factor of 2 of the combined QPN limit for a 160 ms probe time with ~10^3 atoms in each clock. We further demonstrate that even at this high p...

  7. A Faster Algorithm for Solving One-Clock Priced Timed Games

    DEFF Research Database (Denmark)

    Hansen, Thomas Dueholm; Ibsen-Jensen, Rasmus; Miltersen, Peter Bro

    2012-01-01

    previously known time bound for solving one-clock priced timed games was 2^(O(n^2+m)), due to Rutkowski. For our improvement, we introduce and study a new algorithm for solving one-clock priced timed games, based on the sweep-line technique from computational geometry and the strategy iteration paradigm from...... the algorithmic theory of Markov decision processes. As a corollary, we also improve the analysis of previous algorithms due to Bouyer, Cassez, Fleury, and Larsen; and Alur, Bernadsky, and MadhusudanWe present a construction of log-depth formulae for various threshold functions based on atomic threshold gates...... multiplicative. Our formulas can also be used to construct multiparty protocols from protocols for a constant number of parties. In particular we implement black-box multiparty computation over non-Abelian groups in a way that is much simpler than previously known and we also show how to get a protocol...

  8. Probe light-shift elimination in generalized hyper-Ramsey quantum clocks

    Science.gov (United States)

    Zanon-Willette, T.; de Clercq, E.; Arimondo, E.

    2016-04-01

    We present an interrogation scheme for the next generation of quantum clocks to suppress frequency shifts induced by laser probing fields that are themselves based on generalized hyper-Ramsey resonances. Sequences of composite laser pulses with a specific selection of phases, frequency detunings, and durations are combined to generate a very efficient and robust frequency locking signal with an almost perfect elimination of the light shift from off-resonant states and to decouple the unperturbed frequency measurement from the laser's intensity. The frequency lock point generated from synthesized error signals using either π /4 or 3 π /4 laser phase steps during the intermediate pulse is tightly protected against large laser-pulse area variations and errors in potentially applied frequency shift compensations. Quantum clocks based on weakly allowed or completely forbidden optical transitions in atoms, ions, molecules, and nuclei will benefit from these hyperstable laser frequency stabilization schemes to reach relative accuracies below the 10-18 level.

  9. Light-shift elimination in Generalized Hyper-Ramsey quantum clocks

    CERN Document Server

    Zanon-Willette, Thomas; Arimondo, Ennio

    2015-01-01

    We present a new generation of quantum clocks absolutely free from ac Stark-shift based on generalized hyper-Ramsey resonances with separated oscillating fields. Sequences of composite laser pulses with specific selection of phases, frequency detunings and durations are combined to generate a very efficient and robust frequency locking signal with a perfect elimination of the light-shift from off resonant states. Laser phase-step modulations during interactions with electromagnetic fields are applied in order to decouple the unperturbed frequency measurement from the laser's intensity. The frequency lock point is protected against laser pulse area fluctuations and errors in potentially applied frequency shift compensations. Quantum clocks based on weakly allowed or completely forbidden optical transitions in atoms, ions, molecules and nuclei will benefit from these hyper-stable laser frequency stabilization schemes to reach relative accuracies well below the 10$^{-18}$ level.

  10. Velocity Distribution of Effective Atoms in a Small Optically Pumped Cesium Beam Frequency Standard

    Institute of Scientific and Technical Information of China (English)

    CHEN Jingbiao; WANG Fengzhi; YANG Donghai; WANG YiQiu

    2001-01-01

    In this paper, the velocity distribution of effective atoms in a small optically pumped cesium beam frequency standard has been achieved from the Fourier transforms of the experimentally recorded Ramsey patterns. The result fits well with the theoretical calculation. The second order Doppler shift correction of the small cesium atomic clock is obtained from the velocity distribution of effective atoms.

  11. Stability limits of an optical frequency standard based on free Ca atoms

    CERN Document Server

    Sherman, J A

    2011-01-01

    We have quantified a short term instability budget for an optical frequency standard based on cold, freely expanding calcium atoms. Such systems are the subject of renewed interest due to their high frequency stability and relative technical simplicity compared to trapped atom optical clocks. By filtering the clock laser light at 657 nm through a high finesse cavity, we observe a slight reduction in the optical Dick effect caused by aliased local oscillator noise. The ultimately limiting technical noise is measured using a technique that does not rely on a second clock or fs-comb.

  12. Epigenetic drift, epigenetic clocks and cancer risk.

    Science.gov (United States)

    Zheng, Shijie C; Widschwendter, Martin; Teschendorff, Andrew E

    2016-05-01

    It is well-established that the DNA methylation landscape of normal cells undergoes a gradual modification with age, termed as 'epigenetic drift'. Here, we review the current state of knowledge of epigenetic drift and its potential role in cancer etiology. We propose a new terminology to help distinguish the different components of epigenetic drift, with the aim of clarifying the role of the epigenetic clock, mitotic clocks and active changes, which accumulate in response to environmental disease risk factors. We further highlight the growing evidence that epigenetic changes associated with cancer risk factors may play an important causal role in cancer development, and that monitoring these molecular changes in normal cells may offer novel risk prediction and disease prevention strategies.

  13. Epigenetic drift, epigenetic clocks and cancer risk.

    Science.gov (United States)

    Zheng, Shijie C; Widschwendter, Martin; Teschendorff, Andrew E

    2016-05-01

    It is well-established that the DNA methylation landscape of normal cells undergoes a gradual modification with age, termed as 'epigenetic drift'. Here, we review the current state of knowledge of epigenetic drift and its potential role in cancer etiology. We propose a new terminology to help distinguish the different components of epigenetic drift, with the aim of clarifying the role of the epigenetic clock, mitotic clocks and active changes, which accumulate in response to environmental disease risk factors. We further highlight the growing evidence that epigenetic changes associated with cancer risk factors may play an important causal role in cancer development, and that monitoring these molecular changes in normal cells may offer novel risk prediction and disease prevention strategies. PMID:27104983

  14. The Large Built Water Clock Of Amphiaraeion.

    Science.gov (United States)

    Theodossiou, E.; Katsiotis, M.; Manimanis, V. N.; Mantarakis, P.

    A very well preserved ancient water clock was discovered during excavations at the Amphiaraeion, in Oropos, Greece. The Amphiaraeion, a famous religious and oracle center of the deified healer Amphiaraus, was active from the pre-classic period until the replacement of the ancient religion by Christianity in the 5th Century A.D.. The foretelling was supposedly done through dreams sent by the god to the believers sleeping in a special gallery. In these dreams the god suggesting to them the therapy for their illness or the solution to their problems. The patients, then threw coins into a spring of the sanctuary. In such a place, the measurement of time was a necessity. Therefore, time was kept with both a conical sundial and a water clock in the form of a fountain. According to archeologists, the large built structure that measured the time for the sanctuary dates from the 4th Century B.C.

  15. Molecular clock on a neutral network.

    Science.gov (United States)

    Raval, Alpan

    2007-09-28

    The number of fixed mutations accumulated in an evolving population often displays a variance that is significantly larger than the mean (the overdispersed molecular clock). By examining a generic evolutionary process on a neutral network of high-fitness genotypes, we establish a formalism for computing all cumulants of the full probability distribution of accumulated mutations in terms of graph properties of the neutral network, and use the formalism to prove overdispersion of the molecular clock. We further show that significant overdispersion arises naturally in evolution when the neutral network is highly sparse, exhibits large global fluctuations in neutrality, and small local fluctuations in neutrality. The results are also relevant for elucidating aspects of neutral network topology from empirical measurements of the substitution process.

  16. Clock drawing performance in cognitively normal elderly

    OpenAIRE

    Hubbard, E J; Santini, V; Blankevoort, C.G.; Volkers, K.M.; Barrup, M.S.; Byerly, L; Chaisson, C.; Jefferson, A.L.; Kaplan, E; Green, R.C.; Stern, R. A.

    2008-01-01

    The Clock Drawing Test (CDT) is a common neuropsychological measure sensitive to cognitive changes and functional skills (e.g., driving test performance) among older adults. However, normative data have not been adequately developed. We report the distribution of CDT scores using three common scoring systems (Mendez, Ala, and Underwood, 1992; Freund, Gravenstein, Ferris, Burke, & Shaheen, 2005; and Cahn, Salmon, Monsch, Butters, Wiederholt, & Corey-Bloom, 1996), among 207 cognitively normal e...

  17. Absolute clock synchronisation and special relativity paradoxes

    OpenAIRE

    Ciborowski, Jacek; Wlodarczyk, Marta

    2012-01-01

    Solving special relativity paradoxes requires rigorous analysis of event timing, due to relative simultaneity in consequence of the Lorentz transformation. Since clock synchronisation is a convention in special theory of relativity, instead of the Einstein's procedure one may choose such that offers absolute simultaneity. We present in short the corresponding formalism in one spatial dimension. We show that paradoxes do not arise with this choice of synchronisation and descriptions of these i...

  18. The circadian clock, reward and memory

    OpenAIRE

    Urs eAlbrecht

    2011-01-01

    During our daily activities, we experience variations in our cognitive performance, which is often accompanied by cravings for small rewards, such as consuming coffee or chocolate. This indicates that the time of day, cognitive performance, and reward may be related to one another. This review will summarize data that describe the influence of the circadian clock on addiction and mood-related behavior and put the data into perspective in relation to memory processes.

  19. Molecular clock in neutral protein evolution

    Directory of Open Access Journals (Sweden)

    Wilke Claus O

    2004-08-01

    Full Text Available Abstract Background A frequent observation in molecular evolution is that amino-acid substitution rates show an index of dispersion (that is, ratio of variance to mean substantially larger than one. This observation has been termed the overdispersed molecular clock. On the basis of in silico protein-evolution experiments, Bastolla and coworkers recently proposed an explanation for this observation: Proteins drift in neutral space, and can temporarily get trapped in regions of substantially reduced neutrality. In these regions, substitution rates are suppressed, which results in an overall substitution process that is not Poissonian. However, the simulation method of Bastolla et al. is representative only for cases in which the product of mutation rate μ and population size Ne is small. How the substitution process behaves when μNe is large is not known. Results Here, I study the behavior of the molecular clock in in silico protein evolution as a function of mutation rate and population size. I find that the index of dispersion decays with increasing μNe, and approaches 1 for large μNe . This observation can be explained with the selective pressure for mutational robustness, which is effective when μNe is large. This pressure keeps the population out of low-neutrality traps, and thus steadies the ticking of the molecular clock. Conclusions The molecular clock in neutral protein evolution can fall into two distinct regimes, a strongly overdispersed one for small μNe, and a mostly Poissonian one for large μNe. The former is relevant for the majority of organisms in the plant and animal kingdom, and the latter may be relevant for RNA viruses.

  20. Photoperiodic plasticity in circadian clock neurons in insects

    Directory of Open Access Journals (Sweden)

    Sakiko eShiga

    2013-08-01

    Full Text Available Since Bünning’s observation of circadian rhythms and photoperiodism in the runner bean Phaseolus multiflorus in 1936, many studies have shown that photoperiodism is based on the circadian clock system. In insects, involvement of circadian clock genes or neurons has been recently shown in the photoperiodic control of developmental arrests, diapause. Based on molecular and neuronal studies in Drosophila melanogaster, photoperiodic changes have been reported for expression patterns of the circadian clock genes, subcellular distribution of clock proteins, fiber distribution, or the number of plausible clock neurons in different species. Photoperiod sets peaks of per or tim mRNA abundance at lights-off in Sarcophaga crassipalpis, Chymomyza costata and Protophormia terraenovae. Abundance of per and Clock mRNA changes by photoperiod in Pyrrhocoris apterus. Subcellular Per distribution in circadian clock neurons changes with photoperiod in P. terraenovae. Although photoperiodism is not known in Leucophaea maderae, under longer day length, more stomata and longer commissural fibers of circadian clock neurons have been found. These plastic changes in the circadian clock neurons could be an important constituent for photoperiodic clock mechanisms to integrate repetitive photoperiodic information and produce different outputs based on day length.

  1. Geopotential measurements with synchronously linked optical lattice clocks

    Science.gov (United States)

    Takano, Tetsushi; Takamoto, Masao; Ushijima, Ichiro; Ohmae, Noriaki; Akatsuka, Tomoya; Yamaguchi, Atsushi; Kuroishi, Yuki; Munekane, Hiroshi; Miyahara, Basara; Katori, Hidetoshi

    2016-10-01

    According to Einstein's theory of relativity, the passage of time changes in a gravitational field. On Earth, raising a clock by 1 cm increases its apparent tick rate by 1.1 parts in 1018, allowing chronometric levelling through comparison of optical clocks. Here, we demonstrate such geopotential measurements by determining the height difference of master and slave clocks separated by 15 km with an uncertainty of 5 cm. A subharmonic of the master clock laser is delivered through a telecom fibre to synchronously operate the distant clocks. Clocks operated under such phase coherence reject clock laser noise and facilitate proposals for linking clocks and interferometers. Taken over half a year, 11 measurements determine the fractional frequency difference between the two clocks to be 1,652.9(5.9) × 10-18, consistent with an independent measurement by levelling and gravimetry. Our system demonstrates a building block for an internet of clocks, which may constitute ‘quantum benchmarks’, serving as height references with dynamic responses.

  2. Regulated DNA Methylation and the Circadian Clock: Implications in Cancer

    Directory of Open Access Journals (Sweden)

    Tammy M. Joska

    2014-09-01

    Full Text Available Since the cloning and discovery of DNA methyltransferases (DNMT, there has been a growing interest in DNA methylation, its role as an epigenetic modification, how it is established and removed, along with the implications in development and disease. In recent years, it has become evident that dynamic DNA methylation accompanies the circadian clock and is found at clock genes in Neurospora, mice and cancer cells. The relationship among the circadian clock, cancer and DNA methylation at clock genes suggests a correlative indication that improper DNA methylation may influence clock gene expression, contributing to the etiology of cancer. The molecular mechanism underlying DNA methylation at clock loci is best studied in the filamentous fungi, Neurospora crassa, and recent data indicate a mechanism analogous to the RNA-dependent DNA methylation (RdDM or RNAi-mediated facultative heterochromatin. Although it is still unclear, DNA methylation at clock genes may function as a terminal modification that serves to prevent the regulated removal of histone modifications. In this capacity, aberrant DNA methylation may serve as a readout of misregulated clock genes and not as the causative agent. This review explores the implications of DNA methylation at clock loci and describes what is currently known regarding the molecular mechanism underlying DNA methylation at circadian clock genes.

  3. Clock drawing performance in cognitively normal elderly.

    Science.gov (United States)

    Hubbard, Emily J; Santini, Veronica; Blankevoort, Christiaan G; Volkers, Karin M; Barrup, Melissa S; Byerly, Laura; Chaisson, Christine; Jefferson, Angela L; Kaplan, Edith; Green, Robert C; Stern, Robert A

    2008-05-01

    The Clock Drawing Test (CDT) is a common neuropsychological measure sensitive to cognitive changes and functional skills (e.g., driving test performance) among older adults. However, normative data have not been adequately developed. We report the distribution of CDT scores using three common scoring systems [Mendez, M. F., Ala, T., & Underwood, K. L. (1992). Development of scoring criteria for the Clock Drawing Task in Alzheimer's Disease. Journal of the American Geriatrics Society, 40, 1095-1099; Cahn, D. A., Salmon, D. P., Monsch, A. U., Butters, N., Wiederholt, W. C., & Corey-Bloom, J. (1996). Screening for dementia of the Alzheimer type in the community: The utility of the Clock Drawing Test. Archives of Clinical Neuropsychology, 11(6), 529-539], among 207 cognitively normal elderly. The systems were well correlated, took little time to use, and had high inter-rater reliability. We found statistically significant differences in CDT scores based on age and WRAT-3 Reading score, a marker of education quality. We present means, standard deviations, and t- and z-scores based on these subgroups. We found that "normal" CDT performance includes a wider distribution of scores than previously reported. Our results may serve as useful comparisons for clinicians wishing to know whether their patients perform in the general range of cognitively normal elderly. PMID:18243644

  4. A microresonator frequency comb optical clock

    CERN Document Server

    Papp, Scott B; DelHaye, Pascal; Quinlan, Franklyn; Lee, Hansuek; Vahala, Kerry J; Diddams, Scott A

    2013-01-01

    Optical-frequency combs enable measurement precision at the 20th digit, and accuracy entirely commensurate with their reference oscillator. A new direction in experiments is the creation of ultracompact frequency combs by way of nonlinear parametric optics in microresonators. We refer to these as microcombs, and here we report a silicon-chip-based microcomb optical clock that phase-coherently converts an optical-frequency reference to a microwave signal. A low-noise comb spectrum with 25 THz span is generated with a 2 mm diameter silica disk and broadening in nonlinear fiber. This spectrum is stabilized to rubidium frequency references separated by 3.5 THz by controlling two teeth 108 modes apart. The optical clocks output is the electronically countable 33 GHz microcomb line spacing, which features an absolute stability better than the rubidium transitions by the expected factor of 108. Our work demonstrates the comprehensive set of tools needed for interfacing microcombs to state-of-the-art optical clocks.

  5. Dual cesium and rubidium atomic fountain with a 10-16 level accuracy and applications

    International Nuclear Information System (INIS)

    Atomic fountains are the most accomplished development of the atomic clocks based on the cesium atom whose hyperfine resonance defines the SI second since 1967. Today these systems are among those which realize the second with the best accuracy. We present the last developments of the cold cesium and rubidium atom dual fountain experiment at LNE-SYRTE. This unique dual setup would allow to obtain an outstanding resolution in fundamental physics tests based on atomic transition frequency comparisons. In order to enable operation with both atomic species simultaneously, we designed, tested and implemented on the fountain new collimators which combine the laser lights corresponding to each atom. By comparing our rubidium fountain to another cesium fountain over a decade, we performed a test of the stability of the fine structure constant at the level of 5 * 10-16 per year. We carried on the work on the clock accuracy and we focused on the phase gradients effects in the interrogation cavity and on the microwave leakage. The fountain accuracy has been evaluated to 4 * 10-16 for the cesium clock and to 5 * 10-16 for the refurbished rubidium clock. As a powerful instrument of metrology, our fountain was implicated in many clock comparisons and contributed many times to calibrate the International Atomic Time. Furthermore, we used the fountain to perform a new test of Lorentz local invariance. (author)

  6. Atom interferometry and the Einstein equivalence principle

    CERN Document Server

    Wolf, Peter; Bordé, Christian J; Reynaud, Serge; Salomon, Christophe; Cohen-Tannoudji, Clande

    2011-01-01

    The computation of the phase shift in a symmetric atom interferometer in the presence of a gravitational field is reviewed. The difference of action-phase integrals between the two paths of the interferometer is zero for any Lagrangian which is at most quadratic in position and velocity. We emphasize that in a large class of theories of gravity the atom interferometer permits a test of the weak version of the equivalence principle (or universality of free fall) by comparing the acceleration of atoms with that of ordinary bodies, but is insensitive to that aspect of the equivalence principle known as the gravitational redshift or universality of clock rates.

  7. Self-Adaptive Clock Synchronization for Computational Grid

    Institute of Scientific and Technical Information of China (English)

    ZHAO Ying(赵英); ZHOU WanLei(周万雷); HUANG JiuMei(黄九梅); YU Shui(余水); E.J.Lanham

    2003-01-01

    This paper presents an innovative method to synchronize physical clocks for a computational grid, in particular for a computational grid linked through the asynchronous Intranet or Internet environments. The method discussed is an asynchronous self-adaptive clock synchronization mechanism. Two strategies for clock synchronisation are introduced. (1) Use continuous time intervals to calculate the precision of clocks, which can reduce the effect of network delay efficiently. (2) Every node synchronizes its clock with its leader actively. In addition, a node self-adaptive model is presented, and the relationship between the clock precision and synchronization time is induced, hence a node can predict when it should begin the synchronization process.Detailed simulation and extension of this issue are provided at the end of the paper. The presented model is both practical and feasible.

  8. A clock network for geodesy and fundamental science

    CERN Document Server

    Lisdat, C; Quintin, N; Shi, C; Raupach, S M F; Grebing, C; Nicolodi, D; Stefani, F; Al-Masoudi, A; Dörscher, S; Häfner, S; Robyr, J -L; Chiodo, N; Bilicki, S; Bookjans, E; Koczwara, A; Koke, S; Kuhl, A; Wiotte, F; Meynadier, F; Camisard, E; Abgrall, M; Lours, M; Legero, T; Schnatz, H; Sterr, U; Denker, H; Chardonnet, C; Coq, Y Le; Santarelli, G; Amy-Klein, A; Targat, R Le; Lodewyck, J; Lopez, O; Pottie, P -E

    2015-01-01

    Leveraging the unrivaled performance of optical clocks in applications in fundamental physics beyond the standard model, in geo-sciences, and in astronomy requires comparing the frequency of distant optical clocks truthfully. Meeting this requirement, we report on the first comparison and agreement of fully independent optical clocks separated by 700 km being only limited by the uncertainties of the clocks themselves. This is achieved by a phase-coherent optical frequency transfer via a 1415 km long telecom fiber link that enables substantially better precision than classical means of frequency transfer. The fractional precision in comparing the optical clocks of three parts in $10^{17}$ was reached after only 1000 s averaging time, which is already 10 times better and more than four orders of magnitude faster than with any other existing frequency transfer method. The capability of performing high resolution international clock comparisons paves the way for a redefinition of the unit of time and an all-optic...

  9. Electromagnetic synchronisation of clocks with finite separation in a rotating system

    International Nuclear Information System (INIS)

    For clocks on the vertices of a triangle, it is shown that clock synchronisation using electromagnetic signals between finitely spaced clocks in a rotating frame leads to the same synchronisation error as a closely spaced band of clocks along the same light path. In addition, the above result is generalised to n equally spaced clocks. (author)

  10. Clock rates, clock settings and the physics of the space-time Lorentz transformation

    CERN Document Server

    Field, J H

    2006-01-01

    A careful study is made of the operational meaning of the time symbols appearing in the space-time Lorentz transformation. Four distinct symbols, with different physical meanings, are needed to describe reciprocal measurements involving stationary and uniformly-moving clocks. Physical predictions concern only the observed rate of a clock as a function of its relative speed, not its setting. How the failure to make this distinction leads to the conventional predictions of spurious `relativity of simultaneity' and `length contraction' effects in special relativity is explained.

  11. The circadian clock and cell cycle: Interconnected biological circuits

    OpenAIRE

    Masri, Selma; Cervantes, Marlene; Sassone-Corsi, Paolo

    2013-01-01

    The circadian clock governs biological timekeeping on a systemic level, helping to regulate and maintain physiological processes, including endocrine and metabolic pathways with a periodicity of 24-hours. Disruption within the circadian clock machinery has been linked to numerous pathological conditions, including cancer, suggesting that clock-dependent regulation of the cell cycle is an essential control mechanism. This review will highlight recent advances on the ‘gating’ controls of the ci...

  12. Relativity theory and time perception: single or multiple clocks?

    Directory of Open Access Journals (Sweden)

    Catalin V Buhusi

    Full Text Available BACKGROUND: Current theories of interval timing assume that humans and other animals time as if using a single, absolute stopwatch that can be stopped or reset on command. Here we evaluate the alternative view that psychological time is represented by multiple clocks, and that these clocks create separate temporal contexts by which duration is judged in a relative manner. Two predictions of the multiple-clock hypothesis were tested. First, that the multiple clocks can be manipulated (stopped and/or reset independently. Second, that an event of a given physical duration would be perceived as having different durations in different temporal contexts, i.e., would be judged differently by each clock. METHODOLOGY/PRINCIPAL FINDINGS: Rats were trained to time three durations (e.g., 10, 30, and 90 s. When timing was interrupted by an unexpected gap in the signal, rats reset the clock used to time the "short" duration, stopped the "medium" duration clock, and continued to run the "long" duration clock. When the duration of the gap was manipulated, the rats reset these clocks in a hierarchical order, first the "short", then the "medium", and finally the "long" clock. Quantitative modeling assuming re-allocation of cognitive resources in proportion to the relative duration of the gap to the multiple, simultaneously timed event durations was used to account for the results. CONCLUSIONS/SIGNIFICANCE: These results indicate that the three event durations were effectively timed by separate clocks operated independently, and that the same gap duration was judged relative to these three temporal contexts. Results suggest that the brain processes the duration of an event in a manner similar to Einstein's special relativity theory: A given time interval is registered differently by independent clocks dependent upon the context.

  13. Clocks and dynamics in quantum models of gravity

    OpenAIRE

    Malkiewicz, Przemyslaw

    2016-01-01

    We investigate how the quantum dynamics of gravitational models depend on the clocks employed in quantization procedure. Our previous result demonstrates that almost all physical features of quantum cosmological bounces depend on the choice of clock. The vital question whether all the quantum (or, semiclassical) solutions admit, away from the quantum interaction region in the far past and future, invariant asymptotic limits irrespectively of the clock's choice is addressed herein. We analyze ...

  14. Cycle Time Reduction in Trapped Mercury Ion Atomic Frequency Standards

    Science.gov (United States)

    Burt, Eric A.; Tjoelker, Robert L.; Taghavi, Shervin

    2011-01-01

    The use of the mercury ion isotope (201)Hg(+) was examined for an atomic clock. Taking advantage of the faster optical pumping time in (201)Hg(+) reduces both the state preparation and the state readout times, thereby decreasing the overall cycle time of the clock and reducing the impact of medium-term LO noise on the performance of the frequency standard. The spectral overlap between the plasma discharge lamp used for (201)Hg(+) state preparation and readout is much larger than that of the lamp used for the more conventional (199)Hg(+). There has been little study of (201)Hg(+) for clock applications (in fact, all trapped ion clock work in mercury has been with (199)Hg(+); however, recently the optical pumping time in (201)Hg(+) has been measured and found to be 0.45 second, or about three times faster than in (199)Hg(+) due largely to the better spectral overlap. This can be used to reduce the overall clock cycle time by over 2 seconds, or up to a factor of 2 improvement. The use of the (201)Hg(+) for an atomic clock is totally new. Most attempts to reduce the impact of LO noise have focused on reducing the interrogation time. In the trapped ion frequency standards built so far at JPL, the optical pumping time is already at its minimum so that no enhancement can be had by shortening it. However, by using (201)Hg(+), this is no longer the case. Furthermore, integrity monitoring, the mechanism that determines whether the clock is functioning normally, cannot happen faster than the clock cycle time. Therefore, a shorter cycle time will enable quicker detection of failure modes and recovery from them.

  15. A Simple Loop for Simultaneous OTDM Demultiplexing and Clock Recovery

    Institute of Scientific and Technical Information of China (English)

    CHEN Ming; LU Dan; GONG Tao-Rong; LV Bo; WANG Mu-Guang; LI Tang-Jun; JIAN Shui-Sheng

    2009-01-01

    A simple and stable loop consisting of a pair of concatenated electroabsorption modulators (EAMs) and 10 GHz clock recovery module is presented and demonstrated experimentally for simultaneous demultiplexing and clock recovery for OTDM networks. The 1OGb/s demultiplexed signai and IOGHz recovered clock are successfully implemented from 80 Gbit/s and 160 Gbit/s OTDM signals utilizing the loop. The loop based on EAM-PLL can provide excellent tolerance range (> 5 dB) of the OSCR of the source laser, and the recovered clock signa J exhibits low rms jitter over a dynamic input optical power range of 15 dB.

  16. Real-time geopotentiometry with synchronously linked optical lattice clocks

    CERN Document Server

    Takano, Tetsushi; Ushijima, Ichiro; Ohmae, Noriaki; Akatsuka, Tomoya; Yamaguchi, Atsushi; Kuroishi, Yuki; Munekane, Hiroshi; Miyahara, Basara; Katori, Hidetoshi

    2016-01-01

    According to the Einstein's theory of relativity, the passage of time changes in a gravitational field. On earth, raising a clock by one centimetre increases its tick rate by 1.1 parts in 10$^{18}$, enabling optical clocks to perform precision geodesy. Here, we demonstrate geopotentiometry by determining the height difference of master and slave clocks separated by 15 km with uncertainty of 5 cm. The subharmonic of the master clock is delivered through a telecom fibre to phase-lock and synchronously interrogate the slave clock. This protocol rejects laser noise in the comparison of two clocks, which improves the stability of measuring the gravitational red shift. Such phase-coherently operated clocks facilitate proposals for linking clocks and interferometers. Over half a year, 11 measurements determine the fractional frequency difference between the two clocks to be $1,652.9(5.9)\\times 10^{-18}$, or a height difference of 1,516(5) cm, consistent with an independent measurement by levelling and gravimetry. Ou...

  17. Temperature regulates transcription in the zebrafish circadian clock.

    Directory of Open Access Journals (Sweden)

    2005-11-01

    Full Text Available It has been well-documented that temperature influences key aspects of the circadian clock. Temperature cycles entrain the clock, while the period length of the circadian cycle is adjusted so that it remains relatively constant over a wide range of temperatures (temperature compensation. In vertebrates, the molecular basis of these properties is poorly understood. Here, using the zebrafish as an ectothermic model, we demonstrate first that in the absence of light, exposure of embryos and primary cell lines to temperature cycles entrains circadian rhythms of clock gene expression. Temperature steps drive changes in the basal expression of certain clock genes in a gene-specific manner, a mechanism potentially contributing to entrainment. In the case of the per4 gene, while E-box promoter elements mediate circadian clock regulation, they do not direct the temperature-driven changes in transcription. Second, by studying E-box-regulated transcription as a reporter of the core clock mechanism, we reveal that the zebrafish clock is temperature-compensated. In addition, temperature strongly influences the amplitude of circadian transcriptional rhythms during and following entrainment by light-dark cycles, a property that could confer temperature compensation. Finally, we show temperature-dependent changes in the expression levels, phosphorylation, and function of the clock protein, CLK. This suggests a mechanism that could account for changes in the amplitude of the E-box-directed rhythm. Together, our results imply that several key transcriptional regulatory elements at the core of the zebrafish clock respond to temperature.

  18. Transcripts from the Circadian Clock: Telling Time and Season

    OpenAIRE

    Brand, Karl

    2011-01-01

    textabstractWe all know it when we wake mere moments before an alarm clock is scheduled to wake us: our body clock made the alarm clock redundant. This phenomenon is driven by an endogenous timer known as the biological, or circadian clock. Each revolution of the Earth about its own axis produces periods of light and dark which define what we all experience as a ‘day’. This profound cyclic variation in solar energy is responsible for driving the evolution of adaptive responses as early as 3.8...

  19. Power and Skew Aware Point Diffusion Clock Network

    Science.gov (United States)

    Jung, Gunok; Kim, Chunghee; Chae, Kyoungkuk; Park, Giho; Park, Sung Bae

    This letter presents point diffusion clock network (PDCN) with local clock tree synthesis (CTS) scheme. The clock network is implemented with ten times wider metal line space than typical mesh networks for low power and utilized to nine times smaller area CTS execution for minimized clock skew amount. The measurement results show that skew amount of PDCN with local CTS is reduced to 36% and latency is shrunk to 45% of the amount in a 4.81mm2 CortexA-8 core with 65nm Samsung process.

  20. Glucocorticoids entrain molecular clock components in human peripheral cells.

    Science.gov (United States)

    Cuesta, Marc; Cermakian, Nicolas; Boivin, Diane B

    2015-04-01

    In humans, shift work induces a desynchronization between the circadian system and the outside world, which contributes to shift work-associated medical disorders. Using a simulated night shift experiment, we previously showed that 3 d of bright light at night fully synchronize the central clock to the inverted sleep schedule, whereas the peripheral clocks located in peripheral blood mononuclear cells (PBMCs) took longer to reset. This underlines the need for testing the effects of synchronizers on both the central and peripheral clocks. Glucocorticoids display circadian rhythms controlled by the central clock and are thought to act as synchronizers of rodent peripheral clocks. In the present study, we tested whether the human central and peripheral clocks were sensitive to exogenous glucocorticoids (Cortef) administered in the late afternoon. We showed that 20 mg Cortef taken orally acutely increased PER1 expression in PBMC peripheral clocks. After 6 d of Cortef administration, the phases of central markers were not affected, whereas those of PER2-3 and BMAL1 expression in PBMCs were shifted by ∼ 9.5-11.5 h. These results demonstrate, for the first time, that human peripheral clocks are entrained by glucocorticoids. Importantly, they suggest innovative interventions for shift workers and jet-lag travelers, combining synchronizing agents for the central and peripheral clocks.

  1. The molecular clock regulates circadian transcription of tissue factor gene.

    Science.gov (United States)

    Oishi, Katsutaka; Koyanagi, Satoru; Ohkura, Naoki

    2013-02-01

    Tissue factor (TF) is involved in endotoxin-induced inflammation and mortality. We found that the circadian expression of TF mRNA, which peaked at the day to night transition (activity onset), was damped in the liver of Clock mutant mice. Luciferase reporter and chromatin immunoprecipitation analyses using embryonic fibroblasts derived from wild-type or Clock mutant mice showed that CLOCK is involved in transcription of the TF gene. Furthermore, the results of real-time luciferase reporter experiments revealed that the circadian expression of TF mRNA is regulated by clock molecules through a cell-autonomous mechanism via an E-box element located in the promoter region.

  2. Precision Spectroscopy of Atomic Hydrogen

    Science.gov (United States)

    Beyer, A.; Parthey, Ch G.; Kolachevsky, N.; Alnis, J.; Khabarova, K.; Pohl, R.; Peters, E.; Yost, D. C.; Matveev, A.; Predehl, K.; Droste, S.; Wilken, T.; Holzwarth, R.; Hänsch, T. W.; Abgrall, M.; Rovera, D.; Salomon, Ch; Laurent, Ph; Udem, Th

    2013-12-01

    Precise determinations of transition frequencies of simple atomic systems are required for a number of fundamental applications such as tests of quantum electrodynamics (QED), the determination of fundamental constants and nuclear charge radii. The sharpest transition in atomic hydrogen occurs between the metastable 2S state and the 1S ground state. Its transition frequency has now been measured with almost 15 digits accuracy using an optical frequency comb and a cesium atomic clock as a reference [1]. A recent measurement of the 2S - 2P3/2 transition frequency in muonic hydrogen is in significant contradiction to the hydrogen data if QED calculations are assumed to be correct [2, 3]. We hope to contribute to this so-called "proton size puzzle" by providing additional experimental input from hydrogen spectroscopy.

  3. Cold Atom Source Containing Multiple Magneto-Optical Traps

    Science.gov (United States)

    Ramirez-Serrano, Jaime; Kohel, James; Kellogg, James; Lim, Lawrence; Yu, Nan; Maleki, Lute

    2007-01-01

    An apparatus that serves as a source of a cold beam of atoms contains multiple two-dimensional (2D) magneto-optical traps (MOTs). (Cold beams of atoms are used in atomic clocks and in diverse scientific experiments and applications.) The multiple-2D-MOT design of this cold atom source stands in contrast to single-2D-MOT designs of prior cold atom sources of the same type. The advantages afforded by the present design are that this apparatus is smaller than prior designs.

  4. Telomere biology: cancer firewall or aging clock?

    Science.gov (United States)

    Mitteldorf, J J

    2013-09-01

    It has been a decade since the first surprising discovery that longer telomeres in humans are statistically associated with longer life expectancies. Since then, it has been firmly established that telomere shortening imposes an individual fitness cost in a number of mammalian species, including humans. But telomere shortening is easily avoided by application of telomerase, an enzyme which is coded into nearly every eukaryotic genome, but whose expression is suppressed most of the time. This raises the question how the sequestration of telomerase might have evolved. The predominant assumption is that in higher organisms, shortening telomeres provide a firewall against tumor growth. A more straightforward interpretation is that telomere attrition provides an aging clock, reliably programming lifespans. The latter hypothesis is routinely rejected by most biologists because the benefit of programmed lifespan applies only to the community, and in fact the individual pays a substantial fitness cost. There is a long-standing skepticism that the concept of fitness can be applied on a communal level, and of group selection in general. But the cancer hypothesis is problematic as well. Animal studies indicate that there is a net fitness cost in sequestration of telomerase, even when cancer risk is lowered. The hypothesis of protection against cancer has never been tested in animals that actually limit telomerase expression, but only in mice, whose lifespans are not telomerase-limited. And human medical evidence suggests a net aggravation of cancer risk from the sequestration of telomerase, because cells with short telomeres are at high risk of neoplastic transformation, and they also secrete cytokines that exacerbate inflammation globally. The aging clock hypothesis fits well with what is known about ancestral origins of telomerase sequestration, and the prejudices concerning group selection are without merit. If telomeres are an aging clock, then telomerase makes an

  5. Clocks underneath: the role of peripheral clocks in the timing of female reproductive physiology

    Directory of Open Access Journals (Sweden)

    Michael T Sellix

    2013-07-01

    Full Text Available The central circadian pacemaker in the suprachiasmatic nucleus (SCN is a critical component of the neuroendocrine circuit controlling gonadotropin secretion from the pituitary gland. The SCN conveys photic information to hypothalamic targets including the gonadotropin releasing hormone (GnRH neurons. Many of these target cells are also cell autonomous clocks. It has been suggested that, rather then being singularly driven by the SCN, the timing of gonadotropin secretion depends on the activity of multiple hypothalamic oscillators. While this view provides a novel twist to an old story, it does little to diminish the central role of rhythmic hypothalamic output in this system. It is now clear that the pituitary, ovary, uterus and oviduct have functional molecular clocks. Evidence supports the notion that the clocks in these tissues contribute to the timing of events in reproductive physiology. The goal of this review is to highlight the current evidence for molecular clock function in the peripheral components of the female hypothalamo-pituitary-gonadal (HPG axis as it relates to the timing of gonadotropin secretion, ovulation and parturition.

  6. The Space Optical Clocks Project: Development of high-performance transportable and breadboard optical clocks and advanced subsystems

    CERN Document Server

    Schiller, S; Nevsky, A; Alighanbari, S; Vasilyev, S; Abou-Jaoudeh, C; Mura, G; Franzen, T; Sterr, U; Falke, S; Lisdat, Ch; Rasel, E; Kulosa, A; Bize, S; Lodewyck, J; Tino, G M; Poli, N; Schioppo, M; Bongs, K; Singh, Y; Gill, P; Barwood, G; Ovchinnikov, Y; Stuhler, J; Kaenders, W; Braxmaier, C; Holzwarth, R; Donati, A; Lecomte, S; Calonico, D; Levi, F

    2012-01-01

    The use of ultra-precise optical clocks in space ("master clocks") will allow for a range of new applications in the fields of fundamental physics (tests of Einstein's theory of General Relativity, time and frequency metrology by means of the comparison of distant terrestrial clocks), geophysics (mapping of the gravitational potential of Earth), and astronomy (providing local oscillators for radio ranging and interferometry in space). Within the ELIPS-3 program of ESA, the "Space Optical Clocks" (SOC) project aims to install and to operate an optical lattice clock on the ISS towards the end of this decade, as a natural follow-on to the ACES mission, improving its performance by at least one order of magnitude. The payload is planned to include an optical lattice clock, as well as a frequency comb, a microwave link, and an optical link for comparisons of the ISS clock with ground clocks located in several countries and continents. Undertaking a necessary step towards optical clocks in space, the EU-FP7-SPACE-2...

  7. Modified hyper-Ramsey methods for the elimination of probe shifts in optical clocks

    CERN Document Server

    Hobson, R; King, S A; Baird, P E G; Hill, I R; Gill, P

    2016-01-01

    We develop a new extension of existing techniques of hyper-Ramsey spectroscopy in optical clocks, achieving complete immunity to the frequency shifts induced by the probing fields themselves. Using particular pulse sequences with tailored phases, frequencies, and durations, we can derive an error signal centered exactly at the unperturbed atomic resonance with a steep discriminant which is robust against variations in the probe shift. We experimentally investigate the scheme using the magnetically-induced $^1$S$_0- ^3$P$_0$ transition in $^{88}$Sr, demonstrating automatic suppression of a sizeable \

  8. The ac Stark shifts of the terahertz clock transitions of barium

    Institute of Scientific and Technical Information of China (English)

    余庚华; 耿鹰鸽; 李隆; 周超; 段丞博; 柴瑞鹏; 杨永明

    2015-01-01

    Wavelength-dependent AC Stark shifts and magic wavelengths of the terahertz clock transitions between the metastable triplet states 6s5d 3D1 and 6s5d 3D2 are investigated with considering the optical lattice trapping of barium atoms with the linearly polarized laser. The trap depths and the slopes of light shift difference with distinct magic wave-lengths of the optical lattices are also discussed in detail. Several potentially suitable working points for the optical lattice trapping laser are recommended and selected from these magic wavelengths.

  9. Quantum optics and nuclear clocks: a look at the 2012 physics nobel prize

    International Nuclear Information System (INIS)

    Pioneering researches in the field of quantum optics are presented. These have laid the foundation for photonics research, that has grasped the particle properties of light to create new technologies and deepen the understanding of the physical laws. The quantum computation and quantum clocks have been highlighted. Individual particles have managed to manipulate without losing its properties in quantum, using photons to immobilize atoms with electric charges (ions) and study their properties. Researches conducted by the French scientist Serge Haroche and American David Wineland nobel prize winners for Physics 2012, have been commented

  10. Grand-mother clocks and quiet lasers

    OpenAIRE

    Arnaud, Jacques; Chusseau, Laurent; Philippe, Fabrice

    2009-01-01

    7 pages Galileo noted in the 16th century that the period of oscillation of a pendulum is almost independent of the amplitude. However, such a pendulum is damped by air friction. The latter may be viewed as resulting from air molecules getting in contact with the pendulum. It follows that air friction, not only damps the oscillation, but also introduces randomness. In the so-called ``grand-mother'' clock, discovered by Huygens in the 18th century, damping is compensated for, on the average...

  11. A precise clock distribution network for MRPC-based experiments

    Science.gov (United States)

    Wang, S.; Cao, P.; Shang, L.; An, Q.

    2016-06-01

    In high energy physics experiments, the MRPC (Multi-Gap Resistive Plate Chamber) detectors are widely used recently which can provide higher-resolution measurement for particle identification. However, the application of MRPC detectors leads to a series of challenges in electronics design with large number of front-end electronic channels, especially for distributing clock precisely. To deal with these challenges, this paper presents a universal scheme of clock transmission network for MRPC-based experiments with advantages of both precise clock distribution and global command synchronization. For precise clock distributing, the clock network is designed into a tree architecture with two stages: the first one has a point-to-multipoint long range bidirectional distribution with optical channels and the second one has a fan-out structure with copper link inside readout crates. To guarantee the precision of clock frequency or phase, the r-PTP (reduced Precision Time Protocol) and the DDMTD (digital Dual Mixer Time Difference) methods are used for frequency synthesis, phase measurement and adjustment, which is implemented by FPGA (Field Programmable Gate Array) in real-time. In addition, to synchronize global command execution, based upon this clock distribution network, synchronous signals are coded with clock for transmission. With technique of encoding/decoding and clock data recovery, signals such as global triggers or system control commands, can be distributed to all front-end channels synchronously, which greatly simplifies the system design. The experimental results show that both the clock jitter (RMS) and the clock skew can be less than 100 ps.

  12. Dopamine receptor-mediated regulation of neuronal "clock" gene expression.

    Science.gov (United States)

    Imbesi, M; Yildiz, S; Dirim Arslan, A; Sharma, R; Manev, H; Uz, T

    2009-01-23

    Using a transgenic mice model (i.e. "clock" knockouts), clock transcription factors have been suggested as critical regulators of dopaminergic behaviors induced by drugs of abuse. Moreover, it has been shown that systemic administration of psychostimulants, such as cocaine and methamphetamine regulates the striatal expression of clock genes. However, it is not known whether dopamine receptors mediate these regulatory effects of psychostimulants at the cellular level. Primary striatal neurons in culture express dopamine receptors as well as clock genes and have been successfully used in studying dopamine receptor functioning. Therefore, we investigated the role of dopamine receptors on neuronal clock gene expression in this model using specific receptor agonists. We found an inhibitory effect on the expression of mClock and mPer1 genes with the D2-class (i.e. D2/D3) receptor agonist quinpirole. We also found a generalized stimulatory effect on the expression of clock genes mPer1, mClock, mNPAS2 (neuronal PAS domain protein 2), and mBmal1 with the D1-class (i.e. D1) receptor agonist SKF38393. Further, we tested whether systemic administration of dopamine receptor agonists causes similar changes in striatal clock gene expression in vivo. We found quinpirole-induced alterations in mPER1 protein levels in the mouse striatum (i.e. rhythm shift). Collectively, our results indicate that the dopamine receptor system may mediate psychostimulant-induced changes in clock gene expression. Using striatal neurons in culture as a model, further research is needed to better understand how dopamine signaling modulates the expression dynamics of clock genes (i.e. intracellular signaling pathways) and thereby influences neuronal gene expression, neuronal transmission, and brain functioning. PMID:19017537

  13. The Renaissance or the cuckoo clock.

    Science.gov (United States)

    Pines, Jonathon; Hagan, Iain

    2011-12-27

    '…in Italy, for thirty years under the Borgias, they had warfare, terror, murder and bloodshed, but they produced Michelangelo, Leonardo da Vinci and the Renaissance. In Switzerland, they had brotherly love, they had five hundred years of democracy and peace-and what did that produce? The cuckoo clock'. Orson Welles as Harry Lime: The Third Man. Orson Welles might have been a little unfair on the Swiss, after all cuckoo clocks were developed in the Schwartzwald, but, more importantly, Swiss democracy gives remarkably stable government with considerable decision-making at the local level. The alternative is the battling city-states of Renaissance Italy: culturally rich but chaotic at a higher level of organization. As our understanding of the cell cycle improves, it appears that the cell is organized more along the lines of Switzerland than Renaissance Italy, and one major challenge is to determine how local decisions are made and coordinated to produce the robust cell cycle mechanisms that we observe in the cell as a whole.

  14. Animal clocks: when science meets nature.

    Science.gov (United States)

    Kronfeld-Schor, Noga; Bloch, Guy; Schwartz, William J

    2013-08-22

    Daily rhythms of physiology and behaviour are governed by an endogenous timekeeping mechanism (a circadian 'clock'), with the alternation of environmental light and darkness synchronizing (entraining) these rhythms to the natural day-night cycle. Our knowledge of the circadian system of animals at the molecular, cellular, tissue and organismal levels is remarkable, and we are beginning to understand how each of these levels contributes to the emergent properties and increased complexity of the system as a whole. For the most part, these analyses have been carried out using model organisms in standard laboratory housing, but to begin to understand the adaptive significance of the clock, we must expand our scope to study diverse animal species from different taxonomic groups, showing diverse activity patterns, in their natural environments. The seven papers in this Special Feature of Proceedings of the Royal Society B take on this challenge, reviewing the influences of moonlight, latitudinal clines, evolutionary history, social interactions, specialized temporal niches, annual variation and recently appreciated post-transcriptional molecular mechanisms. The papers emphasize that the complexity and diversity of the natural world represent a powerful experimental resource. PMID:23825215

  15. The clock ambiguity: Implications and new developments

    CERN Document Server

    Albrecht, Andreas

    2008-01-01

    We consider the ambiguity associated with the choice of clock in time reparameterization invariant theories. This arbitrariness undermines the goal of prescribing a fixed set of physical laws, since a change of time variable can completely alter the predictions of the theory. We review the main features of the clock ambiguity and our earlier work on its implications for the emergence of physical laws in a statistical manner. We also present a number of new results: We show that (contrary to suggestions in our earlier work) time independent Hamiltonians may quite generally be assumed for laws of physics that emerge in this picture. We also further explore the degree to which the observed Universe can be well approximated by a random Hamiltonian. We discuss the possibility of predicting the dimensionality of space, and also relate the 2nd derivative of the density of states to the heat capacity of the Universe. This new work adds to the viability of our proposal that strong predictions for physical laws may eme...

  16. The role of biological clock in glucose homeostasis 

    Directory of Open Access Journals (Sweden)

    Piotr Chrościcki

    2013-06-01

    Full Text Available The mechanism of the biological clock is based on a rhythmic expression of clock genes and clock-controlled genes. As a result of their transcripto-translational associations, endogenous rhythms in the synthesis of key proteins of various physiological and metabolic processes are created. The major timekeeping mechanism for these rhythms exists in the central nervous system. The master circadian clock, localized in suprachiasmatic nucleus (SCN, regulates multiple metabolic pathways, while feeding behavior and metabolite availability can in turn regulate the circadian clock. It is also suggested that in the brain there is a food entrainable oscillator (FEO or oscillators, resulting in activation of both food anticipatory activity and hormone secretion that control digestion processes. Moreover, most cells and tissues express autonomous clocks. Maintenance of the glucose homeostasis is particularly important for the proper function of the body, as this sugar is the main source of energy for the brain, retina, erythrocytes and skeletal muscles. Thus, glucose production and utilization are synchronized in time. The hypothalamic excited orexin neurons control energy balance of organism and modulate the glucose production and utilization. Deficiency of orexin action results in narcolepsy and weight gain, whereas glucose and amino acids can affect activity of the orexin cells. Large-scale genetic studies in rodents and humans provide evidence for the involvement of disrupted clock gene expression rhythms in the pathogenesis of obesity and type 2 diabetes. In general, the current lifestyle of the developed modern societies disturbs the action of biological clock

  17. Molecular clock integration of brown adipose tissue formation and function

    Science.gov (United States)

    Nam, Deokhwa; Yechoor, Vijay K.; Ma, Ke

    2016-01-01

    Abstract The circadian clock is an essential time-keeping mechanism that entrains internal physiology to environmental cues. Despite the well-established link between the molecular clock and metabolic homeostasis, an intimate interplay between the clock machinery and the metabolically active brown adipose tissue (BAT) is only emerging. Recently, we came to appreciate that the formation and metabolic functions of BAT, a key organ for body temperature maintenance, are under an orchestrated circadian clock regulation. Two complementary studies from our group uncover that the cell-intrinsic clock machinery exerts concerted control of brown adipogenesis with consequent impacts on adaptive thermogenesis, which adds a previously unappreciated temporal dimension to the regulatory mechanisms governing BAT development and function. The essential clock transcriptional activator, Bmal1, suppresses adipocyte lineage commitment and differentiation, whereas the clock repressor, Rev-erbα, promotes these processes. This newly discovered temporal mechanism in fine-tuning BAT thermogenic capacity may enable energy utilization and body temperature regulation in accordance with external timing signals during development and functional recruitment. Given the important role of BAT in whole-body metabolic homeostasis, pharmacological interventions targeting the BAT-modulatory activities of the clock circuit may offer new avenues for the prevention and treatment of metabolic disorders, particularly those associated with circadian dysregulation.

  18. Secure and self-stabilizing clock synchronization in sensor networks

    NARCIS (Netherlands)

    Hoepman, J.H.; Larsson, A.; Schiller, E.M.; Tsigas, P.

    2011-01-01

    In sensor networks, correct clocks have arbitrary starting offsets and nondeterministic fluctuating skews. We consider an adversary that aims at tampering with the clock synchronization by intercepting messages, replaying intercepted messages (after the adversary’s choice of delay), and capturing no

  19. Assignment of circadian function for the Neurospora clock gene frequency

    NARCIS (Netherlands)

    Merrow, Martha; Brunner, Michael; Roenneberg, Till

    1999-01-01

    Circadian clocks consist of three elements: entrainment pathways (inputs), the mechanism generating the rhythmicity (oscillator), and the output pathways that control the circadian rhythms. It is difficult to assign molecular clock components to any one of these elements. Experiments show that input

  20. Molecular clock integration of brown adipose tissue formation and function.

    Science.gov (United States)

    Nam, Deokhwa; Yechoor, Vijay K; Ma, Ke

    2016-01-01

    The circadian clock is an essential time-keeping mechanism that entrains internal physiology to environmental cues. Despite the well-established link between the molecular clock and metabolic homeostasis, an intimate interplay between the clock machinery and the metabolically active brown adipose tissue (BAT) is only emerging. Recently, we came to appreciate that the formation and metabolic functions of BAT, a key organ for body temperature maintenance, are under an orchestrated circadian clock regulation. Two complementary studies from our group uncover that the cell-intrinsic clock machinery exerts concerted control of brown adipogenesis with consequent impacts on adaptive thermogenesis, which adds a previously unappreciated temporal dimension to the regulatory mechanisms governing BAT development and function. The essential clock transcriptional activator, Bmal1, suppresses adipocyte lineage commitment and differentiation, whereas the clock repressor, Rev-erbα, promotes these processes. This newly discovered temporal mechanism in fine-tuning BAT thermogenic capacity may enable energy utilization and body temperature regulation in accordance with external timing signals during development and functional recruitment. Given the important role of BAT in whole-body metabolic homeostasis, pharmacological interventions targeting the BAT-modulatory activities of the clock circuit may offer new avenues for the prevention and treatment of metabolic disorders, particularly those associated with circadian dysregulation.

  1. The circadian clock regulates auxin signaling and responses in Arabidopsis.

    Directory of Open Access Journals (Sweden)

    Michael F Covington

    2007-08-01

    Full Text Available The circadian clock plays a pervasive role in the temporal regulation of plant physiology, environmental responsiveness, and development. In contrast, the phytohormone auxin plays a similarly far-reaching role in the spatial regulation of plant growth and development. Went and Thimann noted 70 years ago that plant sensitivity to auxin varied according to the time of day, an observation that they could not explain. Here we present work that explains this puzzle, demonstrating that the circadian clock regulates auxin signal transduction. Using genome-wide transcriptional profiling, we found many auxin-induced genes are under clock regulation. We verified that endogenous auxin signaling is clock regulated with a luciferase-based assay. Exogenous auxin has only modest effects on the plant clock, but the clock controls plant sensitivity to applied auxin. Notably, we found both transcriptional and growth responses to exogenous auxin are gated by the clock. Thus the circadian clock regulates some, and perhaps all, auxin responses. Consequently, many aspects of plant physiology not previously thought to be under circadian control may show time-of-day-specific sensitivity, with likely important consequences for plant growth and environmental responses.

  2. An Integrated Architectural Clock Implemented Memory Design Analysis

    Directory of Open Access Journals (Sweden)

    Ravi Khatwal

    2015-07-01

    Full Text Available Recently Low power consumption and Custom Memory design is major issue for embedded designer. Micro wind and Xilinx simulator implements SRAM design architecture and performs efficient simulation. These simulators implements high performances and low power consumption of SRAM design. SRAM efficiency analyzed with 6-T architecture design and row/column based architectural design. We have analyzed clock implemented memory design and simulated with specific application. We have implemented clock based SRAM architecture that improves the internal clock efficiency of SRAM. Architectural Clock implemented memory design reduces the propagation delay and access time. Internal semiconductor material design implemented technique also improves the SRAM data transitions scheme. Semiconductor material and clock implemented design improve simulation performance of SRAM and these design implements for recently developed Application Specific Memory Design Architecture and mobile devices.

  3. Clock-turning gait synthesis for humanoid robots

    Institute of Scientific and Technical Information of China (English)

    Zhe TANG; Zengqi SUN; Hongbo LIU; Meng Joo ER

    2007-01-01

    Turning gait is a basic motion for humanoid robots.This paper presents a method for humanoid turning.i.e.clock-turning.The objective of clock-turning is to change robot direction at a stationary spot.The clock-turning planning consists of four steps:ankle trajectory generation,hip trajectory generation,knee trajectory generation,and inverse kinematics calculation.Our proposed method is based on a typical humanoid structure with 12 DOFs(degrees of freedom).The final output of clock-turning planning is 12 reference trajectories.which are used to control a humanoid robot wim 12 DOFs.ZMP(zero moment point)is used as stability criterion for the planning.Simulation experiments are conducted to verify the effectiveness of our proposed clock-turning method.

  4. The molecular clock mediates leptin-regulated bone formation.

    Science.gov (United States)

    Fu, Loning; Patel, Millan S; Bradley, Allan; Wagner, Erwin F; Karsenty, Gerard

    2005-09-01

    The hormone leptin is a regulator of bone remodeling, a homeostatic function maintaining bone mass constant. Mice lacking molecular-clock components (Per and Cry), or lacking Per genes in osteoblasts, display high bone mass, suggesting that bone remodeling may also be subject to circadian regulation. Moreover, Per-deficient mice experience a paradoxical increase in bone mass following leptin intracerebroventricular infusion. Thus, clock genes may mediate the leptin-dependent sympathetic regulation of bone formation. We show that expression of clock genes in osteoblasts is regulated by the sympathetic nervous system and leptin. Clock genes mediate the antiproliferative function of sympathetic signaling by inhibiting G1 cyclin expression. Partially antagonizing this inhibitory loop, leptin also upregulates AP-1 gene expression, which promotes cyclin D1 expression, osteoblast proliferation, and bone formation. Thus, leptin determines the extent of bone formation by modulating, via sympathetic signaling, osteoblast proliferation through two antagonistic pathways, one of which involves the molecular clock.

  5. Postnatal ontogenesis of molecular clock in mouse striatum.

    Science.gov (United States)

    Cai, Yanning; Liu, Shu; Li, Ning; Xu, Shengli; Zhang, Yanli; Chan, Piu

    2009-04-01

    Striatum is an important brain area whose function is related to motor, emotion and motivation. Interestingly, biological and physiological circadian rhythms have been found in the striatum extensively, suggesting molecular clock machinery works efficiently therein. However, the striatal expression profiles of clock genes have not been characterized systematically. In addition, little is known about when the expression rhythms start during postnatal ontogenesis. In the present study, 24 h mRNA oscillations of 6 principle clock genes (Bmal1, Clock, Npas2, Cry1, Per1 and Rev-erb alpha) were examined in mouse striatum, at early postnatal stage (postnatal day 3), pre-weaning stage (postnatal day 14) and in adult (postnatal day 60). At P3, no daily oscillation was found for all clock genes. At P14, a significant time effect was identified only for Rev-erb alpha and Npas2. At P60, the daily oscillations of these clock genes were at least borderline significant, with peak time at Circadian time (CT) 01 for Bmal1, Clock, Npas2 and Cry1; at CT 13 for Per1; and at CT 07 for Rev-erb alpha. In addition, the overall mean mRNA levels of these clock genes also underwent a dynamic change postnatally. For Bmal1, Clock, Npas2, Per1 and Rev-erb alpha, the expression level increased throughout the postnatal ontogenesis from P3, P14 to P60. For Cry1, however, the abundance at P3 and P60 were similar while that at P14 was much lower. In conclusion, the striatal molecular clock machinery, although works efficiently in adult, develops gradually after birth in mice.

  6. Atom Chips

    CERN Document Server

    Folman, R; Cassettari, D; Hessmo, B; Maier, T; Schmiedmayer, J; Folman, Ron; Krüger, Peter; Cassettari, Donatella; Hessmo, Björn; Maier, Thomas

    1999-01-01

    Atoms can be trapped and guided using nano-fabricated wires on surfaces, achieving the scales required by quantum information proposals. These Atom Chips form the basis for robust and widespread applications of cold atoms ranging from atom optics to fundamental questions in mesoscopic physics, and possibly quantum information systems.

  7. The genetic basis of the circadian clock : identification of frq and FRQ as clock components in Neurospora

    NARCIS (Netherlands)

    Dunlap, Jay C.; Loros, Jennifer J.; Aronson, Benjamin D.; Merrow, Martha; Crosthwaite, Susan; Bell-Pedersen, Deborah; Johnson, Keith; Lindgren, Kristin; Garceau, Norman Y.

    1995-01-01

    Genetic approaches to the identification of clock components have succeeded in two model systems, Neurospora and Drosophila. In each organism, genes identified through screens for clock-affecting mutations (frq in Neurospora, per in Drosophila) have subsequently been shown to have characteristics of

  8. Transcriptional oscillation of canonical clock genes in mouse peripheral tissues

    Directory of Open Access Journals (Sweden)

    Nakahata Yasukazu

    2004-10-01

    Full Text Available Abstract Background The circadian rhythm of about 24 hours is a fundamental physiological function observed in almost all organisms from prokaryotes to humans. Identification of clock genes has allowed us to study the molecular bases for circadian behaviors and temporal physiological processes such as hormonal secretion, and has prompted the idea that molecular clocks reside not only in a central pacemaker, the suprachiasmatic nuclei (SCN of hypothalamus in mammals, but also in peripheral tissues, even in immortalized cells. Furthermore, previous molecular dissection revealed that the mechanism of circadian oscillation at a molecular level is based on transcriptional regulation of clock and clock-controlled genes. Results We systematically analyzed the mRNA expression of clock and clock-controlled genes in mouse peripheral tissues. Eight genes (mBmal1, mNpas2, mRev-erbα, mDbp, mRev-erbβ, mPer3, mPer1 and mPer2; given in the temporal order of the rhythm peak showed robust circadian expressions of mRNAs in all tissues except testis, suggesting that these genes are core molecules of the molecular biological clock. The bioinformatics analysis revealed that these genes have one or a combination of 3 transcriptional elements (RORE, DBPE, and E-box, which are conserved among human, mouse, and rat genome sequences, and indicated that these 3 elements may be responsible for the biological timing of expression of canonical clock genes. Conclusions The observation of oscillatory profiles of canonical clock genes is not only useful for physiological and pathological examination of the circadian clock in various organs but also important for systematic understanding of transcriptional regulation on a genome-wide basis. Our finding of the oscillatory expression of canonical clock genes with a temporal order provides us an interesting hypothesis, that cyclic timing of all clock and clock-controlled genes may be dependent on several transcriptional elements

  9. Cryptochrome mediates light-dependent magnetosensitivity of Drosophila's circadian clock.

    Directory of Open Access Journals (Sweden)

    Taishi Yoshii

    2009-04-01

    Full Text Available Since 1960, magnetic fields have been discussed as Zeitgebers for circadian clocks, but the mechanism by which clocks perceive and process magnetic information has remained unknown. Recently, the radical-pair model involving light-activated photoreceptors as magnetic field sensors has gained considerable support, and the blue-light photoreceptor cryptochrome (CRY has been proposed as a suitable molecule to mediate such magnetosensitivity. Since CRY is expressed in the circadian clock neurons and acts as a critical photoreceptor of Drosophila's clock, we aimed to test the role of CRY in magnetosensitivity of the circadian clock. In response to light, CRY causes slowing of the clock, ultimately leading to arrhythmic behavior. We expected that in the presence of applied magnetic fields, the impact of CRY on clock rhythmicity should be altered. Furthermore, according to the radical-pair hypothesis this response should be dependent on wavelength and on the field strength applied. We tested the effect of applied static magnetic fields on the circadian clock and found that flies exposed to these fields indeed showed enhanced slowing of clock rhythms. This effect was maximal at 300 muT, and reduced at both higher and lower field strengths. Clock response to magnetic fields was present in blue light, but absent under red-light illumination, which does not activate CRY. Furthermore, cry(b and cry(OUT mutants did not show any response, and flies overexpressing CRY in the clock neurons exhibited an enhanced response to the field. We conclude that Drosophila's circadian clock is sensitive to magnetic fields and that this sensitivity depends on light activation of CRY and on the applied field strength, consistent with the radical pair mechanism. CRY is widespread throughout biological systems and has been suggested as receptor for magnetic compass orientation in migratory birds. The present data establish the circadian clock of Drosophila as a model system

  10. Clock and light regulation of the CREB coactivator CRTC1 in the suprachiasmatic circadian clock.

    Science.gov (United States)

    Sakamoto, Kensuke; Norona, Frances E; Alzate-Correa, Diego; Scarberry, Daniel; Hoyt, Kari R; Obrietan, Karl

    2013-05-22

    The CREB/CRE transcriptional pathway has been implicated in circadian clock timing and light-evoked clock resetting. To date, much of the work on CREB in circadian physiology has focused on how changes in the phosphorylation state of CREB regulate the timing processes. However, beyond changes in phosphorylation, CREB-dependent transcription can also be regulated by the CREB coactivator CRTC (CREB-regulated transcription coactivator), also known as TORC (transducer of regulated CREB). Here we profiled both the rhythmic and light-evoked regulation of CRTC1 and CRTC2 in the murine suprachiasmatic nucleus (SCN), the locus of the master mammalian clock. Immunohistochemical analysis revealed rhythmic expression of CRTC1 in the SCN. CRTC1 expression was detected throughout the dorsoventral extent of the SCN in the middle of the subjective day, with limited expression during early night, and late night expression levels intermediate between mid-day and early night levels. In contrast to CRTC1, robust expression of CRTC2 was detected during both the subjective day and night. During early and late subjective night, a brief light pulse induced strong nuclear accumulation of CRTC1 in the SCN. In contrast with CRTC1, photic stimulation did not affect the subcellular localization of CRTC2 in the SCN. Additionally, reporter gene profiling and chromatin immunoprecipitation analysis indicated that CRTC1 was associated with CREB in the 5' regulatory region of the period1 gene, and that overexpression of CRTC1 leads to a marked upregulation in period1 transcription. Together, these data raise the prospect that CRTC1 plays a role in fundamental aspects of SCN clock timing and entrainment.

  11. Dynamics and performance of clock pendulums

    CERN Document Server

    Hoyng, Peter

    2015-01-01

    We analyze the dynamics of a driven, damped pendulum as used in mechanical clocks. We derive equations for the amplitude and phase of the oscillation, on time scales longer than the pendulum period. The equations are first order ODEs and permit fast simulations of the joint effects of circular and escapement errors, friction, and other disturbances for long times. The equations contain two averages of the driving torque over a period, so that the results are not very sensitive to the fine structure of the driving. We adopt a constant-torque escapement and study the stationary pendulum rate as a function of driving torque and friction. We also study the reaction of the pendulum to a sudden change in the driving torque, and to stationary noisy driving. The equations for the amplitude and phase are shown to describe the pendulum dynamics quite well on time scales of one period and longer. Our emphasis is on a clear exposition of the physics.

  12. Clock comparison based on laser ranging technologies

    Science.gov (United States)

    Samain, Etienne

    2015-06-01

    Recent progress in the domain of time and frequency standards has required some important improvements of existing time transfer links. Several time transfer by laser link (T2L2) projects have been carried out since 1972 with numerous scientific or technological objectives. There are two projects currently under exploitation: T2L2 and Lunar Reconnaissance Orbiter (LRO). The former is a dedicated two-way time transfer experiment embedded on the satellite Jason-2 allowing for the synchronization of remote clocks with an uncertainty of 100 ps and the latter is a one-way link devoted for ranging a spacecraft orbiting around the Moon. There is also the Laser Time Transfer (LTT) project, exploited until 2012 and designed in the frame of the Chinese navigation constellation. In the context of future space missions for fundamental physics, solar system science or navigation, laser links are of prime importance and many missions based on that technology have been proposed for these purposes.

  13. Lamb-Dicke spectroscopy of atoms in a hollow-core photonic crystal fibre

    Science.gov (United States)

    Okaba, Shoichi; Takano, Tetsushi; Benabid, Fetah; Bradley, Tom; Vincetti, Luca; Maizelis, Zakhar; Yampol'Skii, Valery; Nori, Franco; Katori, Hidetoshi

    2014-06-01

    Unlike photons, which are conveniently handled by mirrors and optical fibres without loss of coherence, atoms lose their coherence via atom-atom and atom-wall interactions. This decoherence of atoms deteriorates the performance of atomic clocks and magnetometers, and also hinders their miniaturization. Here we report a novel platform for precision spectroscopy. Ultracold strontium atoms inside a kagome-lattice hollow-core photonic crystal fibre are transversely confined by an optical lattice to prevent atoms from interacting with the fibre wall. By confining at most one atom in each lattice site, to avoid atom-atom interactions and Doppler effect, a 7.8-kHz-wide spectrum is observed for the 1S0-3P1(m=0) transition. Atoms singly trapped in a magic lattice in hollow-core photonic crystal fibres improve the optical depth while preserving atomic coherence time.

  14. Lamb-Dicke spectroscopy of atoms in a hollow-core photonic crystal fibre

    CERN Document Server

    Okaba, Shoichi; Benabid, Fetah; Bradley, Tom; Vincetti, Luca; Maizelis, Zakhar; Yampol'skii, Valery; Nori, Franco; Katori, Hidetoshi

    2014-01-01

    Unlike photons, which are conveniently handled by mirrors and optical fibres without loss of coherence, atoms lose their coherence via atom-atom and atom-wall interactions. This decoherence of atoms deteriorates the performance of atomic clocks and magnetometers, and also hinders their miniaturisation. Here we report a novel platform for precision spectroscopy. Ultracold strontium atoms inside a kKagome-lattice hollow-core photonic crystal fibre (HC-PCF) are transversely confined by an optical lattice to prevent atoms from interacting with the fibre wall. By confining at most one atom in each lattice site, to avoid atom-atom interactions and Doppler effect, a 7.8-kHz-wide spectrum is observed for the $^1 S_0-{}^3P_1$ (m=0) transition. Atoms singly trapped in a magic lattice in hollow-core photonic crystal fibresHC-PCFs improve the optical depth while preserving atomic coherence time.

  15. Somitogenesis clock-wave initiation requires differential decay and multiple binding sites for clock protein.

    Directory of Open Access Journals (Sweden)

    Mark Campanelli

    2010-04-01

    Full Text Available Somitogenesis is a process common to all vertebrate embryos in which repeated blocks of cells arise from the presomitic mesoderm (PSM to lay a foundational pattern for trunk and tail development. Somites form in the wake of passing waves of periodic gene expression that originate in the tailbud and sweep posteriorly across the PSM. Previous work has suggested that the waves result from a spatiotemporally graded control protein that affects the oscillation rate of clock-gene expression. With a minimally constructed mathematical model, we study the contribution of two control mechanisms to the initial formation of this gene-expression wave. We test four biologically motivated model scenarios with either one or two clock protein transcription binding sites, and with or without differential decay rates for clock protein monomers and dimers. We examine the sensitivity of wave formation with respect to multiple model parameters and robustness to heterogeneity in cell population. We find that only a model with both multiple binding sites and differential decay rates is able to reproduce experimentally observed waveforms. Our results show that the experimentally observed characteristics of somitogenesis wave initiation constrain the underlying genetic control mechanisms.

  16. Automatic minimisation of micromotion in a 88Sr+ optical clock

    Science.gov (United States)

    Barwood, G. P.; Huang, G.; Klein, H. A.; Gill, P.

    2015-07-01

    Optical clocks based on narrow linewidth transitions in single cold ions confined in RF traps are being developed at a number of laboratories worldwide. For these ion clock systems, excess micromotion can cause both Stark and Doppler frequency shifts and also a degradation of frequency stability as a result of a reduced excitation rate to the clock transition. At NPL, we detect micromotion in our 88Sr+ optical clocks by observing the correlation between photon arrival times and the zero crossing of the RF trap drive signal. Recently, two nominally identical 88Sr+ optical clocks have been operated over several days and their frequencies compared against one another. During this time the dc voltages on the endcap and compensation voltage electrodes required to minimise the micromotion can change significantly, particularly following the loading of an ion. This paper describes an automatic method to monitor and minimise micromotion applicable to single ion clocks and which we demonstrate using our two NPL 88Sr+ ion clocks.

  17. Use of Very Stable Clocks in Satellite Geodesy

    Science.gov (United States)

    Hugentobler, Urs; Romanyuk, Tetyana

    2016-07-01

    Time and frequency play an essential role in satellite geodesy and navigation. Global Navigation Satellite Systems (GNSS) rely on precise measurements of signal travel times. The satellite and receiver clocks involved in measuring this time interval need to be synchronized at the picosecond level. The concept of GNSS allows for an epoch-wise synchronization of space and ground clocks, a feature which is consequently used in satellite geodesy by estimating epoch-wise clock corrections for all clocks in the system, either explicitly or implicitly by forming double differences. Ultra-stable clocks allow to estimate only few parameters for each clock, e.g., offset and drift. The much reduced number of parameters should stabilize GNSS solutions, e.g., tracking network station coordinates. On the other hand systematic errors, e.g., from troposphere or orbit modeling deficiencies or temperature induced hardware delay variations may systematically affect the solutions. The presentation shows trade-offs of modelling higly stable clocks and negative impact of error sources based on simulations.

  18. Automatic minimisation of micromotion in a 88Sr+ optical clock

    International Nuclear Information System (INIS)

    Optical clocks based on narrow linewidth transitions in single cold ions confined in RF traps are being developed at a number of laboratories worldwide. For these ion clock systems, excess micromotion can cause both Stark and Doppler frequency shifts and also a degradation of frequency stability as a result of a reduced excitation rate to the clock transition. At NPL, we detect micromotion in our 88Sr+ optical clocks by observing the correlation between photon arrival times and the zero crossing of the RF trap drive signal. Recently, two nominally identical 88Sr+ optical clocks have been operated over several days and their frequencies compared against one another. During this time the dc voltages on the endcap and compensation voltage electrodes required to minimise the micromotion can change significantly, particularly following the loading of an ion. This paper describes an automatic method to monitor and minimise micromotion applicable to single ion clocks and which we demonstrate using our two NPL 88Sr+ ion clocks. (paper)

  19. Diurnal oscillations of soybean circadian clock and drought responsive genes.

    Directory of Open Access Journals (Sweden)

    Juliana Marcolino-Gomes

    Full Text Available Rhythms produced by the endogenous circadian clock play a critical role in allowing plants to respond and adapt to the environment. While there is a well-established regulatory link between the circadian clock and responses to abiotic stress in model plants, little is known of the circadian system in crop species like soybean. This study examines how drought impacts diurnal oscillation of both drought responsive and circadian clock genes in soybean. Drought stress induced marked changes in gene expression of several circadian clock-like components, such as LCL1-, GmELF4- and PRR-like genes, which had reduced expression in stressed plants. The same conditions produced a phase advance of expression for the GmTOC1-like, GmLUX-like and GmPRR7-like genes. Similarly, the rhythmic expression pattern of the soybean drought-responsive genes DREB-, bZIP-, GOLS-, RAB18- and Remorin-like changed significantly after plant exposure to drought. In silico analysis of promoter regions of these genes revealed the presence of cis-elements associated both with stress and circadian clock regulation. Furthermore, some soybean genes with upstream ABRE elements were responsive to abscisic acid treatment. Our results indicate that some connection between the drought response and the circadian clock may exist in soybean since (i drought stress affects gene expression of circadian clock components and (ii several stress responsive genes display diurnal oscillation in soybeans.

  20. A molecular clock regulates angiopoietin-like protein 2 expression.

    Science.gov (United States)

    Kadomatsu, Tsuyoshi; Uragami, Shota; Akashi, Makoto; Tsuchiya, Yoshiki; Nakajima, Hiroo; Nakashima, Yukiko; Endo, Motoyoshi; Miyata, Keishi; Terada, Kazutoyo; Todo, Takeshi; Node, Koichi; Oike, Yuichi

    2013-01-01

    Various physiological and behavioral processes exhibit circadian rhythmicity. These rhythms are usually maintained by negative feedback loops of core clock genes, namely, CLOCK, BMAL, PER, and CRY. Recently, dysfunction in the circadian clock has been recognized as an important foundation for the pathophysiology of lifestyle-related diseases, such as obesity, cardiovascular disease, and some cancers. We have reported that angiopoietin-like protein 2 (ANGPTL2) contributes to the pathogenesis of these lifestyle-related diseases by inducing chronic inflammation. However, molecular mechanisms underlying regulation of ANGPTL2 expression are poorly understood. Here, we assess circadian rhythmicity of ANGPTL2 expression in various mouse tissues. We observed that ANGPTL2 rhythmicity was similar to that of the PER2 gene, which is regulated by the CLOCK/BMAL1 complex. Promoter activity of the human ANGPTL2 gene was significantly induced by CLOCK and BMAL1, an induction markedly attenuated by CRY co-expression. We also identified functional E-boxes in the ANGPTL2 promoter and observed occupancy of these sites by endogenous CLOCK in human osteosarcoma cells. Furthermore, Cry-deficient mice exhibited arrhythmic Angptl2 expression. Taken together, these data suggest that periodic expression of ANGPTL2 is regulated by a molecular clock.

  1. A molecular clock regulates angiopoietin-like protein 2 expression.

    Directory of Open Access Journals (Sweden)

    Tsuyoshi Kadomatsu

    Full Text Available Various physiological and behavioral processes exhibit circadian rhythmicity. These rhythms are usually maintained by negative feedback loops of core clock genes, namely, CLOCK, BMAL, PER, and CRY. Recently, dysfunction in the circadian clock has been recognized as an important foundation for the pathophysiology of lifestyle-related diseases, such as obesity, cardiovascular disease, and some cancers. We have reported that angiopoietin-like protein 2 (ANGPTL2 contributes to the pathogenesis of these lifestyle-related diseases by inducing chronic inflammation. However, molecular mechanisms underlying regulation of ANGPTL2 expression are poorly understood. Here, we assess circadian rhythmicity of ANGPTL2 expression in various mouse tissues. We observed that ANGPTL2 rhythmicity was similar to that of the PER2 gene, which is regulated by the CLOCK/BMAL1 complex. Promoter activity of the human ANGPTL2 gene was significantly induced by CLOCK and BMAL1, an induction markedly attenuated by CRY co-expression. We also identified functional E-boxes in the ANGPTL2 promoter and observed occupancy of these sites by endogenous CLOCK in human osteosarcoma cells. Furthermore, Cry-deficient mice exhibited arrhythmic Angptl2 expression. Taken together, these data suggest that periodic expression of ANGPTL2 is regulated by a molecular clock.

  2. Crosstalk of clock gene expression and autophagy in aging

    Science.gov (United States)

    Kalfalah, Faiza; Janke, Linda; Schiavi, Alfonso; Tigges, Julia; Ix, Alexander; Ventura, Natascia; Boege, Fritz; Reinke, Hans

    2016-01-01

    Autophagy and the circadian clock counteract tissue degeneration and support longevity in many organisms. Accumulating evidence indicates that aging compromises both the circadian clock and autophagy but the mechanisms involved are unknown. Here we show that the expression levels of transcriptional repressor components of the circadian oscillator, most prominently the human Period homologue PER2, are strongly reduced in primary dermal fibroblasts from aged humans, while raising the expression of PER2 in the same cells partially restores diminished autophagy levels. The link between clock gene expression and autophagy is corroborated by the finding that the circadian clock drives cell-autonomous, rhythmic autophagy levels in immortalized murine fibroblasts, and that siRNA-mediated downregulation of PER2 decreases autophagy levels while leaving core clock oscillations intact. Moreover, the Period homologue lin-42 regulates autophagy and life span in the nematode Caenorhabditis elegans, suggesting an evolutionarily conserved role for Period proteins in autophagy control and aging. Taken together, this study identifies circadian clock proteins as set-point regulators of autophagy and puts forward a model, in which age-related changes of clock gene expression promote declining autophagy levels. PMID:27574892

  3. Lifetime Measurement of Cold Atoms in an Integrating Sphere

    Institute of Scientific and Technical Information of China (English)

    ZHANG Wen-Zhuo; WANG Xu-Cheng; CHENG Hua-Dong; XIAO Ling; LIU Liang; WANG Yu-Zhu

    2009-01-01

    We present an experimental measurement of the lifetime of the cold 87Rb atoms in an integrating sphere.The atoms are cooled by the diffuse light which is generated by the diffuse reflection of laser beams in the integrating sphere.Our result shows that the lifetime is primarily determined by the free fall of the cold 87Rb atoms,and its half-life can reach 40 ms,which is suitable for many experiments,especially for a cold atom clock.

  4. Using a transportable optical clock for chronometric levelling

    Science.gov (United States)

    Lisdat, Christian; Sterr, Uwe; Koller, Silvio; Grotti, Jacopo; Vogt, Stefan; Häfner, Sebastian; Herbers, Sofia; Al-Masoudi, Ali

    2016-07-01

    With their supreme accuracy and precision, optical clocks in combination with new methods of long-distance frequency transfer can be used to determine height differences by measuring the gravitational red shift between two clocks without accumulation of measurement errors, as in classical levelling. We are developing transportable optical clocks for this purpose that will also serve for the technology development regarding optical clocks in Space and for international comparisons between optical clocks that cannot be linked with sufficient accuracy otherwise. In this talk we will focus on the transportable strontium lattice clock that we are developing and its first evaluation. Presently, we achieve a fractional frequency instability of 3 × 10^{-17} after 1000 s averaging time, which is equivalent to a height resolution of 30 cm. The first uncertainty evaluation of the system yielded 7 × 10^{-17}. We expect rapid improvements to an uncertainty of a few parts in 10^{17}. The clock is now located within a car trailer, which requires compact and rugged lasers systems and physics package. Special care has been taken in the design of the ultra-frequency stable interrogation laser that has to achieve fractional frequency instabilities of considerably below 10^{-15}. Typical laboratory constructions of the reference resonator system used to pre-stabilize the laser frequency are not compatible with the requirement of transportability. In an actual levelling campaign, this clock will be connected via a stabilized optical fibre link with another, stationary frequency standard. The measured gravitational red shift will be compared with the ones calculated from potential differences derived with state of the art geodetic data and models. We will discuss the status of measurements of geodetic relevance with optical clocks and give an outlook on our next steps. This work is supported by QUEST, DFG (RTG 1729, CRC 1128), EU-FP7 (FACT) and EMRP (ITOC). The EMRP is jointly funded

  5. The Bird of Time: Cognition and the Avian Biological Clock

    Directory of Open Access Journals (Sweden)

    Vincent Michael Cassone

    2012-03-01

    Full Text Available Avian behavior and physiology are embedded in time at many levels of biological organization. Biological clock function in birds is critical for sleep/wake cycles, but may also regulate the acquisition of place memory, learning of song from tutors, social integration and time-compensated navigation. This relationship has two major implications. First, mechanisms of the circadian clock should be linked in some way to the mechanisms of all these behaviors. How is not yet clear, and evidence that the central clock has effects is piecemeal. Second, selection acting on characters that are linked to the circadian clock should influence aspects of the clock mechanism itself. Little evidence exists for this in birds, but there have been few attempts to assess this idea. At its core, the avian circadian clock is a multi-oscillator system comprising the pineal gland, the retinae and the avian homologues of the suprachiasmatic nuclei, whose mutual interactions ensure coordinated physiological functions, which are in turn synchronized to ambient light cycles via encephalic, pineal and retinal photoreceptors. At the molecular level, avian biological clocks comprise a genetic network of positive elements clock and bmal1 whose interactions with the negative elements period2, period3 and the cryptochromes form an oscillatory feedback loop that circumnavigates the 24 hrs of the day. We assess the possibilities for dual integration of the clock with time-dependent cognitive processes. Closer examination of the molecular, physiological, and behavioral elements of the circadian system would place birds at a very interesting fulcrum in the neurobiology of time in learning, memory and navigation. 

  6. Circadian rhythms, the molecular clock, and skeletal muscle.

    Science.gov (United States)

    Lefta, Mellani; Wolff, Gretchen; Esser, Karyn A

    2011-01-01

    Almost all organisms ranging from single cell bacteria to humans exhibit a variety of behavioral, physiological, and biochemical rhythms. In mammals, circadian rhythms control the timing of many physiological processes over a 24-h period, including sleep-wake cycles, body temperature, feeding, and hormone production. This body of research has led to defined characteristics of circadian rhythms based on period length, phase, and amplitude. Underlying circadian behaviors is a molecular clock mechanism found in most, if not all, cell types including skeletal muscle. The mammalian molecular clock is a complex of multiple oscillating networks that are regulated through transcriptional mechanisms, timed protein turnover, and input from small molecules. At this time, very little is known about circadian aspects of skeletal muscle function/metabolism but some progress has been made on understanding the molecular clock in skeletal muscle. The goal of this chapter is to provide the basic terminology and concepts of circadian rhythms with a more detailed review of the current state of knowledge of the molecular clock, with reference to what is known in skeletal muscle. Research has demonstrated that the molecular clock is active in skeletal muscles and that the muscle-specific transcription factor, MyoD, is a direct target of the molecular clock. Skeletal muscle of clock-compromised mice, Bmal1(-/-) and Clock(Δ19) mice, are weak and exhibit significant disruptions in expression of many genes required for adult muscle structure and metabolism. We suggest that the interaction between the molecular clock, MyoD, and metabolic factors, such as PGC-1, provide a potential system of feedback loops that may be critical for both maintenance and adaptation of skeletal muscle.

  7. Atom chip based generation of entanglement for quantum metrology

    CERN Document Server

    Riedel, Max F; Li, Yun; Hänsch, Theodor W; Sinatra, Alice; Treutlein, Philipp

    2010-01-01

    Atom chips provide a versatile `quantum laboratory on a microchip' for experiments with ultracold atomic gases. They have been used in experiments on diverse topics such as low-dimensional quantum gases, cavity quantum electrodynamics, atom-surface interactions, and chip-based atomic clocks and interferometers. A severe limitation of atom chips, however, is that techniques to control atomic interactions and to generate entanglement have not been experimentally available so far. Such techniques enable chip-based studies of entangled many-body systems and are a key prerequisite for atom chip applications in quantum simulations, quantum information processing, and quantum metrology. Here we report experiments where we generate multi-particle entanglement on an atom chip by controlling elastic collisional interactions with a state-dependent potential. We employ this technique to generate spin-squeezed states of a two-component Bose-Einstein condensate and show that they are useful for quantum metrology. The obser...

  8. Time in the 10,000-Year Clock

    OpenAIRE

    Hillis, Danny; Seaman, Rob; Allen, Steve; Giorgini, Jon

    2011-01-01

    The Long Now Foundation is building a mechanical clock that is designed to keep time for the next 10,000 years. The clock maintains its long-term accuracy by synchronizing to the Sun. The 10,000-Year Clock keeps track of five different types of time: Pendulum Time, Uncorrected Solar Time, Corrected Solar Time, Displayed Solar Time and Orrery Time. Pendulum Time is generated from the mechanical pendulum and adjusted according to the equation of time to produce Uncorrected Solar Time, which is ...

  9. Differential clock comparisons with phase-locked local oscillators

    CERN Document Server

    Hume, David B

    2015-01-01

    We develop protocols that circumvent the laser noise limit in the stability of optical clock comparisons by synchronous probing of two clocks using phase-locked local oscillators. This allows for probe times longer than the laser coherence time, avoids the Dick effect, and supports Heisenberg-limited scaling of measurement precision. We present a model for such frequency comparisons and develop numerical simulations of the protocol with realistic noise sources. This provides a route to reduce frequency ratio measurement durations by more than an order of magnitude as clock inaccuracies reach 1x10^-18.

  10. Relativistic effects for the JUICE on‐board clock

    OpenAIRE

    S. Bauer; Hussmann, H.; J. Mueller; Oberst, J.

    2014-01-01

    We studied relativistic effects on spacecraft clock rates for ESA’s JUICE mission and derived a relationship between dynamical time TDB and on‐board time. We analysed the S/C on‐board clock rate by using the JUICE mission nominal trajectory. We identify significant changes in the rate of the clock due to large changes of the S/C velocity and its distance to the solar system bodies during the various spacecraft operational phases. After ≈ 11.5 years, at the end of the mission, the offset in ti...

  11. Progress Towards a Compact Optical Clock at JPL

    Science.gov (United States)

    Sullivan, Scott; Rellergert, Wade; Grudinin, Ivan; Baumgartel, Lukas; Yu, Nan

    2014-05-01

    The unprecedented stability and accuracy provided by optical clocks allows improved navigation and planetary science in space applications as well as more precise tests of fundamental laws of physics. However, technological advances towards the miniaturization of the physical volume and reduced power consumption of these clocks must be made to suit space-based application. We will describe JPL's effort towards the development of a compact, low-power optical clock based on 171Yb+. This research was carried out at the Jet Propulsion Laboratory, California Institute of Technology, under a contract with the National Aeronautics and Space Administration. Partial support from NASA Fundamental Physics Program is acknowledged.

  12. Circadian Clocks as Modulators of Metabolic Comorbidity in Psychiatric Disorders.

    Science.gov (United States)

    Barandas, Rita; Landgraf, Dominic; McCarthy, Michael J; Welsh, David K

    2015-12-01

    Psychiatric disorders such as schizophrenia, bipolar disorder, and major depressive disorder are often accompanied by metabolic dysfunction symptoms, including obesity and diabetes. Since the circadian system controls important brain systems that regulate affective, cognitive, and metabolic functions, and neuropsychiatric and metabolic diseases are often correlated with disturbances of circadian rhythms, we hypothesize that dysregulation of circadian clocks plays a central role in metabolic comorbidity in psychiatric disorders. In this review paper, we highlight the role of circadian clocks in glucocorticoid, dopamine, and orexin/melanin-concentrating hormone systems and describe how a dysfunction of these clocks may contribute to the simultaneous development of psychiatric and metabolic symptoms. PMID:26483181

  13. High speed fiber-based clock enhancement of NRZ data

    Institute of Scientific and Technical Information of China (English)

    Tong Wu; Kun Qiu

    2005-01-01

    A scheme for all-fiber clock enhancement of non-return-to-zero (NRZ) data based on cross-phase modulation (XPM) effect in nonlinear fibers is proposed and demonstrated in simulation. The simulation results indicate that the clock-to-data ratio of NRZ signals at 64 Gb/s can be increased to 22.94 dB by using this scheme, and the pattern effect in clock enhanced signals is very weak. The ability of high speed operation up to 140 Gb/s of this scheme is also proved in our simulation.

  14. Regulation of behavioral circadian rhythms and clock protein PER1 by the deubiquitinating enzyme USP2

    DEFF Research Database (Denmark)

    Yang, Yaoming; Duguay, David; Bédard, Nathalie;

    2012-01-01

    Endogenous 24-hour rhythms are generated by circadian clocks located in most tissues. The molecular clock mechanism is based on feedback loops involving clock genes and their protein products. Post-translational modifications, including ubiquitination, are important for regulating the clock...

  15. Atom chips

    CERN Document Server

    Reichel, Jakob

    2010-01-01

    This book provides a stimulating and multifaceted picture of a rapidly developing field. The first part reviews fundamentals of atom chip research in tutorial style, while subsequent parts focus on the topics of atom-surface interaction, coherence on atom chips, and possible future directions of atom chip research. The articles are written by leading researchers in the field in their characteristic and individual styles.

  16. Open Core Protocol (OCP) Clock Domain Crossing Interfaces

    DEFF Research Database (Denmark)

    Herlev, Mathias; Poulsen, Christian Keis; Sparsø, Jens

    2014-01-01

    The open core protocol (OCP) is an openly licensed configurable and scalable interface protocol for on-chip subsystem communications. The protocol defines read and write transactions from a master towards a slave across a point-to-point connection and the protocol assumes a single common clock....... This paper presents the design of two OCP clock domain crossing interface modules that can be used to construct systems with multiple clock domains. An OCP interface typically has control signals related to both the master issuing a read or write request and the slave producing a response. If all...... these control signals are passed across the clock-domain boundary and synchronized it may add significant latency to the duration of a transaction. Our interface designs avoid this and synchronize only a single signal transition in each direction during a read or a write transaction. While the problem...

  17. Clocked, fast electronics trigger for high energy physics

    Energy Technology Data Exchange (ETDEWEB)

    Gray, R.; Rutherfoord, J.P.

    1986-04-01

    For a Fermilab experiment we have designed and built gated-pulse-stretcher modules which allow us to clock all of the fast electronics with the accelerator rf, thus simplifying the trigger design. (orig.).

  18. Speed of light as measured by two terrestrial stable clocks

    International Nuclear Information System (INIS)

    It is shown that despite the recent criticism within the special theory of relativity there exists an arrangement of stable clocks rotating with the earth which predicts diurnal variations of the one-way speed of light, as suggested previously

  19. Speed of light as measured by two terrestrial stable clocks

    Science.gov (United States)

    Hsu, J. P.; Sherry, T. N.; Chiu, C. B.

    1977-01-01

    Despite the recent criticism within the special theory of relativity, there exists an arrangement of stable clocks rotating with the earth which predicts diurnal variations of the one-way speed of light, as suggested previously.

  20. Complementary approaches to understanding the plant circadian clock

    CERN Document Server

    Akman, Ozgur E; Loewe, Laurence; Troein, Carl; 10.4204/EPTCS.19.1

    2010-01-01

    Circadian clocks are oscillatory genetic networks that help organisms adapt to the 24-hour day/night cycle. The clock of the green alga Ostreococcus tauri is the simplest plant clock discovered so far. Its many advantages as an experimental system facilitate the testing of computational predictions. We present a model of the Ostreococcus clock in the stochastic process algebra Bio-PEPA and exploit its mapping to different analysis techniques, such as ordinary differential equations, stochastic simulation algorithms and model-checking. The small number of molecules reported for this system tests the limits of the continuous approximation underlying differential equations. We investigate the difference between continuous-deterministic and discrete-stochastic approaches. Stochastic simulation and model-checking allow us to formulate new hypotheses on the system behaviour, such as the presence of self-sustained oscillations in single cells under constant light conditions. We investigate how to model the timing of...

  1. Clocks and dynamics in quantum models of gravity

    CERN Document Server

    Malkiewicz, Przemyslaw

    2016-01-01

    We investigate how the quantum dynamics of gravitational models depend on the clocks employed in quantization procedure. Our previous result demonstrates that almost all physical features of quantum cosmological bounces depend on the choice of clock. The vital question whether all the quantum (or, semiclassical) solutions admit, away from the quantum interaction region in the far past and future, invariant asymptotic limits irrespectively of the clock's choice is addressed herein. We analyze the semiclassical dynamics of the Bianchi Type I model undergoing a quantum bounce. Our result follows from the universal principle of the free choice of clock and thus, it applies to all quantum gravity models based on the concept of the physical Hilbert space and inner dynamics. Then we propose a suitable interpretation of quantum models of gravity. As a by-product of the pursuit of our main goal, we elaborate the semiclassical description of anisotropic singularity resolution.

  2. Synthesising gene clock with toggle switch and oscillator.

    Science.gov (United States)

    Lin, Chun-Liang; Chen, Po-Kuei; Cheng, Young-Yi

    2015-06-01

    The usefulness of a genetic clock lies in its role to stimulate a sequence of logic reactions for sequential biological circuits. A clock signal is a periodic square wave, its amplitude alternates at a steady frequency between fixed minimal and maximal levels. Transition between the minimum and the maximum is instantaneous for an ideal square wave; however, the function is unrealisable in physical bio-systems. This research develops a new genetic clock generator based on a genetic oscillator, in which, a sine wave generator is adopted as a signal oscillator. It is shown that combination of a genetic oscillator with a toggle switch is able to generate clock signals forming an efficient way to generate a near square wave. In silico study confirms the proposed idea.

  3. The clock paradox in a static homogeneous gravitational field

    CERN Document Server

    Jones, P; Jones, Preston; Wanex, Lucas F.

    2006-01-01

    The gedanken experiment of the clock paradox is solved exactly using the general relativistic equations for a static homogeneous gravitational field. We demonstrate that the general and special relativistic clock paradox solutions are identical and in particular that they are identical for finite acceleration. Practical expressions are obtained for proper time and coordinate time by using the destination distance as the key observable parameter. This solution provides a formal demonstration of the identity between the special and general relativistic clock paradox with finite acceleration and where proper time is assumed to be the same in both formalisms. By solving the equations of motion for a freely falling clock in a static homogeneous field elapsed times are calculated for realistic journeys to the stars.

  4. Bounds on gravitational wave backgrounds from large distance clock comparisons

    CERN Document Server

    Reynaud, Serge; Duchayne, Loic; Wolf, Peter; Jaekel, Marc-Thierry

    2008-01-01

    Our spacetime is filled with gravitational wave backgrounds that constitute a fluctuating environment created by astrophysical and cosmological sources. Bounds on these backgrounds are obtained from cosmological and astrophysical data but also by analysis of ranging and Doppler signals from distant spacecraft. We propose here a new way to set bounds on those backgrounds by performing clock comparisons between a ground clock and a remote spacecraft equipped with an ultra-stable clock, rather than only ranging to an onboard transponder. This technique can then be optimized as a function of the signal to be measured and the dominant noise sources, leading to significant improvements on present bounds in a promising frequency range where different theoretical models are competing. We illustrate our approach using the SAGAS project which aims to fly an ultra stable optical clock in the outer solar system.

  5. Time in motion: the molecular clock meets the microbiome.

    Science.gov (United States)

    Liang, Xue; Bushman, Frederic D; FitzGerald, Garret A

    2014-10-23

    Thaiss et al. report that the intestinal microbiota undergoes diurnal oscillation, which is controlled by host feeding time. Disruption of the host circadian clock induces dysbiosis, which is associated with host metabolic disorders.

  6. Clock synchronization of a broadband seismometer through IEEE-1588 protocol

    OpenAIRE

    Pallares, Oriol; Río Fernandez, Joaquín del; Shariat Panahi, Shahram

    2010-01-01

    In seismology, the time of the signal acquisition is highly important in order to know the magnitude and location of the earthquake. This paper presents the tests carried out to synchronize the seismometer clock through the IEEE-1588 protocol.

  7. A Low-jitter 2.5-to-10 GHz Clock Multiplier Unit in CMOS

    OpenAIRE

    Beek, van, P.; Vaucher, C.S.; Leenaerts, D. M. W.; Klumperink, E.A.M.; Nauta, B.

    2003-01-01

    This paper demonstrates a low-jitter clock multiplier unit [1] that generates a 10 GHz output clock from a 2.5 GHz reference clock. An integrated 10 GHz LCoscillator is locked to the input clock, using a simple and fast phase detector circuit. This phase detector overcomes the speed limitation of a conventional tri-state Phase Frequency Detector, by eliminating an internal feedback loop. A frequency detector guarantees PLL locking without degenerating jitter performance. The clock multiplier ...

  8. A clock synchronization method based on IEEE 1588 and its implementation on Ethernet

    Institute of Scientific and Technical Information of China (English)

    XU Wan; CHEN You-ping; CHEN Bing; XIE Jing-ming

    2008-01-01

    We presented a clock synchronization method that contained a clock adjusting algorithm and a frequency compensated clock to achieve precise synchronization among distributed clocks based on IEEE 1588 protocol. Further, we presented its application on Ethernet and implementation of the frequency compensated clock in a field programmable gate array (FPGA) as experiments. The results indicate that this method can support sub-microsecond synchronization with inexpensive standard crystal oscillators.

  9. Cold atom quantum sensors for space

    Science.gov (United States)

    Singh, Yeshpal

    2016-07-01

    Quantum sensors based on cold atoms offer the opportunity to perform highly accurate measurements of physical phenomena related to time, gravity and rotation. The deployment of such technologies in the microgravity environment of space may enable further enhancement of their performance, whilst permitting the detection of these physical phenomena over much larger scales than is possible with a ground-based instrument. In this talk, I will present an overview of the activities of the UK National Quantum Hub in Sensors and Metrology in developing cold atoms technology for space. Our activities are focused in two main areas: optical clocks and atom interferometers. I will also discuss our contributions to recent initiatives including STE-QUEST and AI-GOAT, the ESA/NASA initiative aiming at an atom interferometer gravitational wave detector in space.

  10. Laser cooling and trapping of ytterbium atoms

    Institute of Scientific and Technical Information of China (English)

    Xin-ye XU; Wen-li WANG; Qing-hong ZHOU; Guo-hui LI; Hai-ling JIANG; Lin-fang CHEN; Jie YE; Zhi-hong ZHOU; Yin CAI; Hai-yao TANG; Min ZHOU

    2009-01-01

    The experiments on the laser cooling and trapping of ytterbium atoms are reported, including the two-dimensional transversal cooling, longitudinal velocity Zeeman deceleration, and a magneto-optical trap with a broadband transition at a wavelength of 399 nm. The magnetic field distributions along the axis of a Zeeman slower were measured and in a good agreement with the calculated results. Cold ytterbium atoms were produced with a number of about 107 and a temperature of a few milli-Kelvin.In addition, using a 556-nm laser, the excitations of cold tterbium atoms at 1S0-3p1 transition were observed. The ytterbium atoms will be further cooled in a 556-nm magneto-optical trap and loaded into a three-dimensional optical lattice to make an ytterbium optical clock.

  11. Atom Interferometers and the Gravitational Redshift

    CERN Document Server

    Sinha, Supurna

    2011-01-01

    Muller, Peters and Chu (MPC) claim that a reinterpretation of decade old experiments with atom interferometers leads to a sensitive test of the gravitational redshift effect. This claim has been disputed by Wolf et al (WBBRSC), who adduce arguments to show that MPC's claim is incorrect. In this Letter, we distill the arguments offered by WBBRSC to a single fundamental objection: an atom is not a clock ticking at the Compton frequency. We show that atom interferometric experiments conducted to date do not test the gravitational redshift effect. Our analysis is general and focuses on points of principle rather thanon the present state of technology. We then observe that it is in principle possible to use atom lasers to produce sensitive tests of the red shift effect at the Compton frequency. Such tests may become technologically realisable in the future.

  12. Atomic Physics

    CERN Document Server

    Foot, Christopher J

    2007-01-01

    This text will thoroughly update the existing literature on atomic physics. Intended to accompany an advanced undergraduate course in atomic physics, the book will lead the students up to the latest advances and the applications to Bose-Einstein Condensation of atoms, matter-wave inter-ferometry and quantum computing with trapped ions. The elementary atomic physics covered in the early chapters should be accessible to undergraduates when they are first introduced to the subject. To complement. the usual quantum mechanical treatment of atomic structure the book strongly emphasizes the experimen

  13. Improving X10 Program Performances by Clock Removal

    OpenAIRE

    Feautrier, Paul; Violard, Eric; Ketterlin, Alain

    2014-01-01

    X10 is a promising recent parallel language designed specifically to address the challenges of productively programming a wide variety of target platforms. The sequential core of X10 is an object-oriented language in the Java family. This core is augmented by a few parallel constructs that create activities as a generalization of the well known fork/join model. Clocks are a generalization of the familiar barriers. Synchronization on a clock is specified by the advance() method call. Activitie...

  14. Tissue-intrinsic dysfunction of circadian clock confers transplant arteriosclerosis.

    Science.gov (United States)

    Cheng, Bo; Anea, Ciprian B; Yao, Lin; Chen, Feng; Patel, Vijay; Merloiu, Ana; Pati, Paramita; Caldwell, R William; Fulton, David J; Rudic, R Daniel

    2011-10-11

    The suprachiasmatic nucleus of the brain is the circadian center, relaying rhythmic environmental and behavioral information to peripheral tissues to control circadian physiology. As such, central clock dysfunction can alter systemic homeostasis to consequently impair peripheral physiology in a manner that is secondary to circadian malfunction. To determine the impact of circadian clock function in organ transplantation and dissect the influence of intrinsic tissue clocks versus extrinsic clocks, we implemented a blood vessel grafting approach to surgically assemble a chimeric mouse that was part wild-type (WT) and part circadian clock mutant. Arterial isografts from donor WT mice that had been anastamosed to common carotid arteries of recipient WT mice (WT:WT) exhibited no pathology in this syngeneic transplant strategy. Similarly, when WT grafts were anastamosed to mice with disrupted circadian clocks, the structural features of the WT grafts immersed in the milieu of circadian malfunction were normal and absent of lesions, comparable to WT:WT grafts. In contrast, aortic grafts from Bmal1 knockout (KO) or Period-2,3 double-KO mice transplanted into littermate control WT mice developed robust arteriosclerotic disease. These lesions observed in donor grafts of Bmal1-KO were associated with up-regulation in T-cell receptors, macrophages, and infiltrating cells in the vascular grafts, but were independent of hemodynamics and B and T cell-mediated immunity. These data demonstrate the significance of intrinsic tissue clocks as an autonomous influence in experimental models of arteriosclerotic disease, which may have implications with regard to the influence of circadian clock function in organ transplantation.

  15. Motion and gravity effects in the precision of quantum clocks

    OpenAIRE

    Lindkvist, Joel; Sabín, Carlos; Johansson, Göran; Fuentes, Ivette

    2014-01-01

    We show that motion and gravity affect the precision of quantum clocks. We consider a localised quantum field as a fundamental model of a quantum clock moving in spacetime and show that its state is modified due to changes in acceleration. By computing the quantum Fisher information we determine how relativistic motion modifies the ultimate bound in the precision of the measurement of time. While in the absence of motion the squeezed vacuum is the ideal state for time estimation, we find that...

  16. Rethinking transcriptional activation in the Arabidopsis circadian clock.

    Science.gov (United States)

    Fogelmark, Karl; Troein, Carl

    2014-07-01

    Circadian clocks are biological timekeepers that allow living cells to time their activity in anticipation of predictable daily changes in light and other environmental factors. The complexity of the circadian clock in higher plants makes it difficult to understand the role of individual genes or molecular interactions, and mathematical modelling has been useful in guiding clock research in model organisms such as Arabidopsis thaliana. We present a model of the circadian clock in Arabidopsis, based on a large corpus of published time course data. It appears from experimental evidence in the literature that most interactions in the clock are repressive. Hence, we remove all transcriptional activation found in previous models of this system, and instead extend the system by including two new components, the morning-expressed activator RVE8 and the nightly repressor/activator NOX. Our modelling results demonstrate that the clock does not need a large number of activators in order to reproduce the observed gene expression patterns. For example, the sequential expression of the PRR genes does not require the genes to be connected as a series of activators. In the presented model, transcriptional activation is exclusively the task of RVE8. Predictions of how strongly RVE8 affects its targets are found to agree with earlier interpretations of the experimental data, but generally we find that the many negative feedbacks in the system should discourage intuitive interpretations of mutant phenotypes. The dynamics of the clock are difficult to predict without mathematical modelling, and the clock is better viewed as a tangled web than as a series of loops.

  17. The Bird of Time: Cognition and the Avian Biological Clock

    OpenAIRE

    Vincent Michael Cassone; David F Westneat

    2012-01-01

    Avian behavior and physiology are embedded in time at many levels of biological organization. Biological clock function in birds is critical for sleep/wake cycles, but may also regulate the acquisition of place memory, learning of song from tutors, social integration and time-compensated navigation. This relationship has two major implications. First, mechanisms of the circadian clock should be linked in some way to the mechanisms of all these behaviors. How is not yet clear, and evidence tha...

  18. The bird of time: cognition and the avian biological clock

    OpenAIRE

    Cassone, Vincent M.; David F Westneat

    2012-01-01

    Avian behavior and physiology are embedded in time at many levels of biological organization. Biological clock function in birds is critical for sleep/wake cycles, but may also regulate the acquisition of place memory, learning of song from tutors, social integration, and time-compensated navigation. This relationship has two major implications. First, mechanisms of the circadian clock should be linked in some way to the mechanisms of all these behaviors. How is not yet clear, and evidence th...

  19. An Integrated Architectural Clock Implemented Memory Design Analysis

    OpenAIRE

    Ravi Khatwal; Manoj Kumar Jain

    2015-01-01

    Recently Low power consumption and Custom Memory design is major issue for embedded designer. Micro wind and Xilinx simulator implements SRAM design architecture and performs efficient simulation. These simulators implements high performances and low power consumption of SRAM design. SRAM efficiency analyzed with 6-T architecture design and row/column based architectural design. We have analyzed clock implemented memory design and simulated with specific application. We have implemented clock...

  20. Clock Face Drawing Test Performance in Children with ADHD

    Directory of Open Access Journals (Sweden)

    Ahmad Ghanizadeh

    2013-01-01

    Full Text Available  Introduction: The utility and discriminatory pattern of the clock face drawing test in ADHD is unclear. This study therefore compared Clock Face Drawing test performance in children with ADHD and controls.   Material & methods: 95 children with ADHD and 191 school children were matched for gender ratio and age. ADHD symptoms severities were assessed using DSM-IV ADHD checklist and their intellectual functioning was assessed. The participants completed three clock-drawing tasks, and the following four functions were assessed: Contour score, Numbers score, Hands setting score, and Center score    Results: All the subscales scores of the three clock drawing tests of the ADHD group were lower than that of the control group. In ADHD children, inattention and hyperactivity/impulsivity scores were not related with free drawn clock test scores. When pre-drawn contour test was performed, inattentiveness score was statistically associated with Number score. None of the other variables of age, gender, intellectual functioning, and hand use preference were associated with Numbers score. In pre-drawn clock, no association of ADHD symptoms with any CDT subscales was significant. In addition, more errors are observed with free drawn clock and Pre-drawn contour than pre-drawn clock.    Conclusion: Putting Numbers and Hands setting are more sensitive measures to screen ADHD than Contour and Center drawing. Test performance, except Hands setting, may have already reached a developmental plateau. It is probable that Hand setting deficit in children with ADHD may not decrease from age 8 to 14 years. Performance of children with ADHD is associated with the complexity of CDT.

  1. Interpretable Machine Learning Models for the Digital Clock Drawing Test

    OpenAIRE

    Souillard-Mandar, William; Davis, Randall; Rudin, Cynthia; Au, Rhoda; Penney, Dana

    2016-01-01

    The Clock Drawing Test (CDT) is a rapid, inexpensive, and popular neuropsychological screening tool for cognitive conditions. The Digital Clock Drawing Test (dCDT) uses novel software to analyze data from a digitizing ballpoint pen that reports its position with considerable spatial and temporal precision, making possible the analysis of both the drawing process and final product. We developed methodology to analyze pen stroke data from these drawings, and computed a large collection of featu...

  2. The clock ambiguity and the emergence of physical laws

    OpenAIRE

    Albrecht, Andreas; Iglesias, Alberto

    2007-01-01

    The process of identifying a time variable in time reparameterization invariant theories results in great ambiguities about the actual laws of physics described by a given theory. A theory set up to describe one set of physical laws can equally well be interpreted as describing any other laws of physics by making a different choice of time variable or ``clock''. In this article we demonstrate how this ``clock ambiguity'' arises and then discuss how one might still hope to extract specific pre...

  3. When the circadian clock meets the melanin pigmentary system.

    Science.gov (United States)

    Slominski, Andrzej T; Hardeland, Rüdiger; Reiter, Russel J

    2015-04-01

    Silencing of BMAL1 and PER1 stimulates melanogenic activity of follicular and epidermal melanocytes, indicating a novel role for peripheral circadian clock processes in the regulation of melanin pigmentation. Linking the expression levels of BMAL1/PER1 with changes in melanogenesis opens exciting opportunities to study the role of the local molecular clock in modulation of melanocyte functions in the hair follicle and the epidermis with attendant effects on epidermal barrier functions in general. PMID:25785947

  4. The Regulation of Segmentation Clock Period in Zebrafish

    OpenAIRE

    Herrgen, Leah

    2008-01-01

    Oscillations are present at many different levels of biological organization. The cell cycle that directs the division of individual cells, the regular depolarization of neurons in the sinu-atrial node which underlies the regular beating of the heart, the circadian rhythms that govern the daily activity cycles of virtually all organisms, and the clocks that make entire populations of fireflies flash on and off in unison feature as prominent examples of biological clocks. During development, b...

  5. Clocks, computers, black holes, spacetime foam, and holographic principle

    OpenAIRE

    Ng, Y. Jack

    2000-01-01

    What do simple clocks, simple computers, black holes, space-time foam, and holographic principle have in common? I will show that the physics behind them is inter-related, linking together our concepts of information, gravity, and quantum uncertainty. Thus, the physics that sets the limits to computation and clock precision also yields Hawking radiation of black holes and the holographic principle. Moreover, the latter two strongly imply that space-time undergoes much larger quantum fluctuati...

  6. Consistency Models in Distributed Systems with Physical Clocks

    OpenAIRE

    Du, Jiaqing

    2014-01-01

    Most existing distributed systems use logical clocks to order events in the implementation of various consistency models. Although logical clocks are straightforward to implement and maintain, they may affect the scalability, availability, and latency of the system when being used to totally order events in strong consistency models. They can also incur considerable overhead when being used to track and check the causal relationships among events in some weak consistency models. In this thesi...

  7. Adrenergic regulation of clock gene expression in mouse liver

    OpenAIRE

    Terazono, Hideyuki; Mutoh, Tatsushi; Yamaguchi, Shun; Kobayashi, Masaki; Akiyama, Masashi; Udo, Rhyuta; Ohdo, Shigehiro; Okamura, Hitoshi; Shibata, Shigenobu

    2003-01-01

    A main oscillator in the suprachiasmatic nucleus (SCN) conveys circadian information to the peripheral clock systems for the regulation of fundamental physiological functions. Although polysynaptic autonomic neural pathways between the SCN and the liver were observed in rats, whether activation of the sympathetic nervous system entrains clock gene expression in the liver has yet to be understood. To assess sympathetic innervation from the SCN to liver tissue, we investigated whether inj...

  8. Clocking In Turbines: Remarks On Physical Nature And Geometric Requirements

    Directory of Open Access Journals (Sweden)

    Swirydczuk Jerzy

    2015-04-01

    Full Text Available The article discusses two issues relating to the clocking phenomenon in turbines, which are the physical course of stator wake deformation in rotor passages and its further interaction with downstream stator blades, and turbine geometry parameters which are believed to be most favourable for clocking. In both cases, the results presented in the article have made it possible to verify and reformulate the previously accepted opinions.

  9. A Clock Enhanced Loop for Simultaneous Error-Free Demultiplexing and Clock Recovery of 160 Gb/s OTDM Signal Single-Channel Transmission over 100 km

    Institute of Scientific and Technical Information of China (English)

    JIA Nan; LI Tang-Jun; ZHONG Kang-Ping; WANG Mu-Guang; CHEN Ming; LI Jing; CHI Jian-Feng

    2010-01-01

    @@ A simple clock enhanced loop of cascaded electro-absorption modulators(EAMs)and 10GHz clock recovery modules is presented.The intensity of harmonic of clock-frequency component is analyzed theoretically and verified experimentally in a 160Gb/s OTDM 100km transmission system.The 10GHz clock component is enhanced obviously before launching into the clock recovery module and the recovered clock signal exhibits low rms jitter of < 400 fs.Moreover,completely error-free(10-12)transmission is observed for more than two hours without using forward error correction technology.The power penalty is about 3.6dB.The proposed loop has merits of enhancing base clock component,simultaneously de-multiplexing and clock recovery,which make the performance of this loop more stable and high suppression of non-target channels.

  10. Atom interferometry

    International Nuclear Information System (INIS)

    We will first present a development of the fundamental principles of atom interferometers. Next we will discuss a few of the various methods now available to split and recombine atomic De Broglie waves, with special emphasis on atom interferometers based on optical pulses. We will also be particularly concerned with high precision interferometers with long measurement times such those made with atomic fountains. The application of atom interferometry to the measurement of the acceleration due to gravity will be detailed. We will also develop the atom interferometry based on adiabatic transfer and we will apply it to the measurement of the photon recoil in the case of the Doppler shift of an atomic resonance caused by the momentum recoil from an absorbed photon. Finally the outlook of future developments will be given. (A.C.)

  11. Time in the 10,000-Year Clock

    CERN Document Server

    Hillis, Danny; Allen, Steve; Giorgini, Jon

    2011-01-01

    The Long Now Foundation is building a mechanical clock that is designed to keep time for the next 10,000 years. The clock maintains its long-term accuracy by synchronizing to the Sun. The 10,000-Year Clock keeps track of five different types of time: Pendulum Time, Uncorrected Solar Time, Corrected Solar Time, Displayed Solar Time and Orrery Time. Pendulum Time is generated from the mechanical pendulum and adjusted according to the equation of time to produce Uncorrected Solar Time, which is in turn mechanically corrected by the Sun to create Corrected Solar Time. Displayed Solar Time advances each time the clock is wound, at which point it catches up with Corrected Solar Time. The clock uses Displayed Solar Time to compute various time indicators to be displayed, including the positions of the Sun, and Gregorian calendar date. Orrery Time is a better approximation of Dynamical Time, used to compute positions of the Moon, planets and stars and the phase of the Moon. This paper describes how the clock reckons ...

  12. A clock network for geodesy and fundamental science.

    Science.gov (United States)

    Lisdat, C; Grosche, G; Quintin, N; Shi, C; Raupach, S M F; Grebing, C; Nicolodi, D; Stefani, F; Al-Masoudi, A; Dörscher, S; Häfner, S; Robyr, J-L; Chiodo, N; Bilicki, S; Bookjans, E; Koczwara, A; Koke, S; Kuhl, A; Wiotte, F; Meynadier, F; Camisard, E; Abgrall, M; Lours, M; Legero, T; Schnatz, H; Sterr, U; Denker, H; Chardonnet, C; Le Coq, Y; Santarelli, G; Amy-Klein, A; Le Targat, R; Lodewyck, J; Lopez, O; Pottie, P-E

    2016-01-01

    Leveraging the unrivalled performance of optical clocks as key tools for geo-science, for astronomy and for fundamental physics beyond the standard model requires comparing the frequency of distant optical clocks faithfully. Here, we report on the comparison and agreement of two strontium optical clocks at an uncertainty of 5 × 10(-17) via a newly established phase-coherent frequency link connecting Paris and Braunschweig using 1,415 km of telecom fibre. The remote comparison is limited only by the instability and uncertainty of the strontium lattice clocks themselves, with negligible contributions from the optical frequency transfer. A fractional precision of 3 × 10(-17) is reached after only 1,000 s averaging time, which is already 10 times better and more than four orders of magnitude faster than any previous long-distance clock comparison. The capability of performing high resolution international clock comparisons paves the way for a redefinition of the unit of time and an all-optical dissemination of the SI-second. PMID:27503795

  13. Register Clustering Methodology for Low Power Clock Tree Synthesis

    Institute of Scientific and Technical Information of China (English)

    邓超; 蔡懿慈; 周强

    2015-01-01

    Clock networks dissipate a significant fraction of the entire chip power budget. Therefore, the optimization for power consumption of clock networks has become one of the most important objectives in high performance IC designs. In contrast to most of the traditional studies that handle this problem with clock routing or buffer insertion strategy, this paper proposes a novel register clustering methodology in generating the leaf level topology of the clock tree to reduce the power consumption. Three register clustering algorithms called KMR, KSR and GSR are developed and a comprehensive study of them is discussed in this paper. Meanwhile, a buffer allocation algorithm is proposed to satisfy the slew constraint within the clusters at a minimum cost of power consumption. We integrate our algorithms into a classical clock tree synthesis (CTS) flow to test the register clustering methodology on ISPD 2010 benchmark circuits. Experimental results show that all the three register clustering algorithms achieve more than 20% reduction in power consumption without affecting the skew and the maximum latency of the clock tree. As the most effective method among the three algorithms, GSR algorithm achieves a 31%reduction in power consumption as well as a 4%reduction in skew and a 5%reduction in maximum latency. Moreover, the total runtime of the CTS flow with our register clustering algorithms is significantly reduced by almost an order of magnitude.

  14. Serum factors in older individuals change cellular clock properties

    Science.gov (United States)

    Pagani, Lucia; Schmitt, Karen; Meier, Fides; Izakovic, Jan; Roemer, Konstanze; Viola, Antoine; Cajochen, Christian; Wirz-Justice, Anna; Brown, Steven A.; Eckert, Anne

    2011-01-01

    Human aging is accompanied by dramatic changes in daily sleep–wake behavior: Activity shifts to an earlier phase, and the consolidation of sleep and wake is disturbed. Although this daily circadian rhythm is brain-controlled, its mechanism is encoded by cell-autonomous circadian clocks functioning in nearly every cell of the body. In fact, human clock properties measured in peripheral cells such as fibroblasts closely mimic those measured physiologically and behaviorally in the same subjects. To understand better the molecular mechanisms by which human aging affects circadian clocks, we characterized the clock properties of fibroblasts cultivated from dermal biopsies of young and older subjects. Fibroblast period length, amplitude, and phase were identical in the two groups even though behavior was not, thereby suggesting that basic clock properties of peripheral cells do not change during aging. Interestingly, measurement of the same cells in the presence of human serum from older donors shortened period length and advanced the phase of cellular circadian rhythms compared with treatment with serum from young subjects, indicating that a circulating factor might alter human chronotype. Further experiments demonstrated that this effect is caused by a thermolabile factor present in serum of older individuals. Thus, even though the molecular machinery of peripheral circadian clocks does not change with age, some age-related circadian dysfunction observed in vivo might be of hormonal origin and therefore might be pharmacologically remediable. PMID:21482780

  15. The Molecular Circadian Clock and Alcohol-Induced Liver Injury

    Science.gov (United States)

    Udoh, Uduak S.; Valcin, Jennifer A.; Gamble, Karen L.; Bailey, Shannon M.

    2015-01-01

    Emerging evidence from both experimental animal studies and clinical human investigations demonstrates strong connections among circadian processes, alcohol use, and alcohol-induced tissue injury. Components of the circadian clock have been shown to influence the pathophysiological effects of alcohol. Conversely, alcohol may alter the expression of circadian clock genes and the rhythmic behavioral and metabolic processes they regulate. Therefore, we propose that alcohol-mediated disruption in circadian rhythms likely underpins many adverse health effects of alcohol that cut across multiple organ systems. In this review, we provide an overview of the circadian clock mechanism and showcase results from new studies in the alcohol field implicating the circadian clock as a key target of alcohol action and toxicity in the liver. We discuss various molecular events through which alcohol may work to negatively impact circadian clock-mediated processes in the liver, and contribute to tissue pathology. Illuminating the mechanistic connections between the circadian clock and alcohol will be critical to the development of new preventative and pharmacological treatments for alcohol use disorders and alcohol-mediated organ diseases. PMID:26473939

  16. The Molecular Circadian Clock and Alcohol-Induced Liver Injury

    Directory of Open Access Journals (Sweden)

    Uduak S. Udoh

    2015-10-01

    Full Text Available Emerging evidence from both experimental animal studies and clinical human investigations demonstrates strong connections among circadian processes, alcohol use, and alcohol-induced tissue injury. Components of the circadian clock have been shown to influence the pathophysiological effects of alcohol. Conversely, alcohol may alter the expression of circadian clock genes and the rhythmic behavioral and metabolic processes they regulate. Therefore, we propose that alcohol-mediated disruption in circadian rhythms likely underpins many adverse health effects of alcohol that cut across multiple organ systems. In this review, we provide an overview of the circadian clock mechanism and showcase results from new studies in the alcohol field implicating the circadian clock as a key target of alcohol action and toxicity in the liver. We discuss various molecular events through which alcohol may work to negatively impact circadian clock-mediated processes in the liver, and contribute to tissue pathology. Illuminating the mechanistic connections between the circadian clock and alcohol will be critical to the development of new preventative and pharmacological treatments for alcohol use disorders and alcohol-mediated organ diseases.

  17. Characterization of a clock based on coherent population trapping in a thermal cesium vapor. Main effects that may affect its mid- and long-term frequency stability

    International Nuclear Information System (INIS)

    This thesis describes a Cs - buffer gas vapor cell atomic clock based on coherent population trapping (CPT), and the main frequency shifts affecting its mid- and long-term stability. The developed atomic clock based on CPT uses two original techniques: a so-called double-Λ scheme for the CPT-resonance excitation and a temporal Ramsey interrogation technique, which produce a high contrast and narrow resonances with reduced light shift dependence. Generally, the mid and long term stability of the vapor cell atomic clock is limited by the collisional shift induced by alkali-buffer gas collisions and the light shift (or the effects depending on the laser intensity). We report on the study of the collisional shift of Cs clock frequency in the presence of Ne, N2 or Ar buffer gas, and its temperature dependence. The coefficient values of this dependence for these three buffer gases were revealed (some of them for the first time), allowing us to realise a cell with optimal combination of buffer gases to cancel the temperature dependence around the working temperature. Following the study of the signal amplitude and the coherence relaxation rate the optimal values for such parameters as interrogation cycle, magnetic field, cell temperature, pressure of the buffer gas mixture, etc. were found for the chosen cell. The investigation on the light shift and the effects depending on the laser intensity allowed us to determine the most sensitive parameters (laser intensity ratio, temperature) and to implement the required stabilizations in order to better control them. Finally, the mid- and long-term clock frequency stability was improved by a factor 40, reaching 2.5 10-14 at 1 hour. (author)

  18. Frequency ratio of Yb and Sr clocks with 5 × 10‑17 uncertainty at 150 seconds averaging time

    Science.gov (United States)

    Nemitz, Nils; Ohkubo, Takuya; Takamoto, Masao; Ushijima, Ichiro; Das, Manoj; Ohmae, Noriaki; Katori, Hidetoshi

    2016-04-01

    Transition frequencies of atoms and ions are among the most accurately accessible quantities in nature, playing important roles in pushing the frontiers of science by testing fundamental laws of physics, in addition to a wide range of applications such as satellite navigation systems. Atomic clocks based on optical transitions approach uncertainties of 10‑18 (refs 1–3), where full frequency descriptions are far beyond the reach of the SI second. Direct measurements of the frequency ratios of such super clocks, on the other hand, are not subject to this limitation. They can verify consistency and overall accuracy for an ensemble of super clocks, an essential step towards a redefinition of the second. Here we report a measurement that finds the frequency ratio of neutral ytterbium and strontium clocks to be ℛ = 1.207507039343337749(55), with a fractional uncertainty of 4.6 × 10‑17 and a measurement instability as low as 4 × 10‑16 (τ/s)‑1/2.

  19. Maternal feeding controls fetal biological clock.

    Directory of Open Access Journals (Sweden)

    Hidenobu Ohta

    Full Text Available BACKGROUND: It is widely accepted that circadian physiological rhythms of the fetus are affected by oscillators in the maternal brain that are coupled to the environmental light-dark (LD cycle. METHODOLOGY/PRINCIPAL FINDINGS: To study the link between fetal and maternal biological clocks, we investigated the effects of cycles of maternal food availability on the rhythms of Per1 gene expression in the fetal suprachiasmatic nucleus (SCN and liver using a transgenic rat model whose tissues express luciferase in vitro. Although the maternal SCN remained phase-locked to the LD cycle, maternal restricted feeding phase-advanced the fetal SCN and liver by 5 and 7 hours respectively within the 22-day pregnancy. CONCLUSIONS/SIGNIFICANCE: Our results demonstrate that maternal feeding entrains the fetal SCN and liver independently of both the maternal SCN and the LD cycle. This indicates that maternal-feeding signals can be more influential for the fetal SCN and particular organ oscillators than hormonal signals controlled by the maternal SCN, suggesting the importance of a regular maternal feeding schedule for appropriate fetal molecular clockwork during pregnancy.

  20. Reduced Voltage Scaling in Clock Distribution Networks

    Directory of Open Access Journals (Sweden)

    Khader Mohammad

    2009-01-01

    Full Text Available We propose a novel circuit technique to generate a reduced voltage swing (RVS signals for active power reduction on main buses and clocks. This is achieved without performance degradation, without extra power supply requirement, and with minimum area overhead. The technique stops the discharge path on the net that is swinging low at a certain voltage value. It reduces active power on the target net by as much as 33% compared to traditional full swing signaling. The logic 0 voltage value is programmable through control bits. If desired, the reduced-swing mode can also be disabled. The approach assumes that the logic 0 voltage value is always less than the threshold voltage of the nMOS receivers, which eliminate the need of the low to high voltage translation. The reduced noise margin and the increased leakage on the receiver transistors using this approach have been addressed through the selective usage of multithreshold voltage (MTV devices and the programmability of the low voltage value.

  1. Chemical clocks for early-type galaxies

    CERN Document Server

    Carretero, C; Beckman, J E

    2007-01-01

    We present a detailed stellar population analysis of 27 massive elliptical galaxies within 4 very rich clusters at redshift z~0.2. We obtained accurate estimates of the mean luminosity-weighted ages and relative abundances of CN, Mg and Fe as functions of the galaxy velocity dispersion, sigma. Our results are compatible with a scenario in which the stellar populations of massive elliptical galaxies, independently of their environment and mass, had formation timescales shorter than ~1 Gyr. This result implies that massive elliptical galaxies have evolved passively since, at least, as long ago as z~2. For a given galaxy mass the duration of star formation is shorter in those galaxies belonging to more dense environments. Finally, we show that the abundance ratios [CN/Fe] and [Mg/Fe] are the key "chemical clocks" to infer the star formation history timescales in ellipticals. In particular, [Mg/Fe] provides an upper limit for those formation timescales, while [CN/Fe] apperars to be the most suitable parameter to ...

  2. Cardiovascular tissues contain independent circadian clocks

    Science.gov (United States)

    Davidson, A. J.; London, B.; Block, G. D.; Menaker, M.

    2005-01-01

    Acute cardiovascular events exhibit a circadian rhythm in the frequency of occurrence. The mechanisms underlying these phenomena are not yet fully understood, but they may be due to rhythmicity inherent in the cardiovascular system. We have begun to characterize rhythmicity of the clock gene mPer1 in the rat cardiovascular system. Luciferase activity driven by the mPer1 gene promoter is rhythmic in vitro in heart tissue explants and a wide variety of veins and arteries cultured from the transgenic Per1-luc rat. The tissues showed between 3 and 12 circadian cycles of gene expression in vitro before damping. Whereas peak per1-driven bioluminescence consistently occurred during the late night in the heart and all arteries sampled, the phases of the rhythms in veins varied significantly by anatomical location. Varying the time of the culture procedure relative to the donor animal's light:dark cycle revealed that, unlike some other rat tissues such as liver, the phases of in vitro rhythms of arteries, veins, and heart explants were affected by culture time. However, phase relationships among tissues were consistent across culture times; this suggests diversity in circadian regulation among components of the cardiovascular system.

  3. Magneto-Optical Trapping of Ytterbium Atoms with a 398.9 nm Laser

    Institute of Scientific and Technical Information of China (English)

    ZHAO Peng-Yi; XIONG Zhuan-Xian; LIANG Jie; HE Ling-Xiang; LU Bao-Long

    2008-01-01

    We report the realization of ytterbium magneto-optical trap (MOT) operating on the dipole-allowed 1S0 - 1P1 transition at 398.9nm. The MOT is loaded by a slowed atomic beam produced by a Zeeman slower. All seven stable isotopes of Yb atoms could be trapped separately at different laser detuning values. Over 107 174Yb atoms are collected in the MOT, whereas the atom number of fermionic isotope 171Yb is roughly 2.3 × 106 due to a lower abundance. Without the Zeeman slower, the trapped atom numbers are one order of magnitude lower.Both the even and odd isotopes are recognized as excellent candidates of optical clock transition, so the cooling and trapping of ytterbium atoms by the blue MOT is an important step for building an optical clock.

  4. Magneto-optical trapping of ytterbium atoms with a 398.9 nm laser

    International Nuclear Information System (INIS)

    We report the realization of ytterbium magneto-optical trap (MOT) operating on the dipole-allowed 1S0-1P1 transition at 398.9 nm. The MOT is loaded by a slowed atomic beam produced by a Zeeman slower. All seven stable isotopes of Yb atoms could be trapped separately at different laser detuning values. Over 107 174Yb atoms are collected in the MOT, whereas the atom number of fermionic isotope 171Yb is roughly 2.3 × 106 due to a lower abundance. Without the Zeeman slower, the trapped atom numbers are one order of magnitude lower. Both the even and odd isotopes are recognized as excellent candidates of optical clock transition, so the cooling and trapping of ytterbium atoms by the blue MOT is an important step for building an optical clock. (authors)

  5. Feasibility of Extreme Ultraviolet Active Optical Clock

    Institute of Scientific and Technical Information of China (English)

    ZHUANG Wei; CHEN Jing-Biao

    2011-01-01

    @@ We propose an experimental scheme of vacuum ultraviolet(VUV)and extreme ultraviolet(XUV)optical fre-quency standards with noble gas atoms.Considering metastable state 3P2 noble atoms pumped by a conventional discharging method,the atomic beam is collimated with transverse laser cooling at the metastable state and en-ters into the laser cavity in the proposed setup.Due to stimulated emission from the metasable state to the ground state inside the laser cavity consisting of VUV reflection coating mirrors,our calculations show that with enough population inversion to compensate for the cavity loss,an active optical frequency standard at VUV and XUV is feasible.

  6. British domestic synchronous clocks 1930-1980 the rise and fall of a technology

    CERN Document Server

    Pook, Leslie Philip

    2015-01-01

    This book complements available one-make books on domestic synchronous clocks. It is also a history of science book that sets British domestic synchronous clocks, their manufacturers and technology in their social context. Part I covers the historical background, British domestic synchronous clock manufacturers and brands, how synchronous clocks work, domestic synchronous clock cases, practical advice on the servicing of domestic synchronous clocks, and analysis of the marketing and reliability of British domestic synchronous clocks. This analysis provides an explanation of the rise and eventual fall of their technology. Part II contains galleries of a selection of British domestic synchronous clocks, and of the movements with which they are fitted. There is a front and back view of each clock, together with a brief description. Views of each movement include views with the movement partly dismantled, together with a brief technical description of the movement. This profusely illustrated book is primarily fo...

  7. Functional Implications of the CLOCK 3111T/C Single-Nucleotide Polymorphism.

    Science.gov (United States)

    Ozburn, Angela R; Purohit, Kush; Parekh, Puja K; Kaplan, Gabrielle N; Falcon, Edgardo; Mukherjee, Shibani; Cates, Hannah M; McClung, Colleen A

    2016-01-01

    Circadian rhythm disruptions are prominently associated with bipolar disorder (BD). Circadian rhythms are regulated by the molecular clock, a family of proteins that function together in a transcriptional-translational feedback loop. The CLOCK protein is a key transcription factor of this feedback loop, and previous studies have found that manipulations of the Clock gene are sufficient to produce manic-like behavior in mice (1). The CLOCK 3111T/C single-nucleotide polymorphism (SNP; rs1801260) is a genetic variation of the human CLOCK gene that is significantly associated with increased frequency of manic episodes in BD patients (2). The 3111T/C SNP is located in the 3'-untranslated region of the CLOCK gene. In this study, we sought to examine the functional implications of the human CLOCK 3111T/C SNP by transfecting a mammalian cell line (mouse embryonic fibroblasts isolated from Clock(-/-) knockout mice) with pcDNA plasmids containing the human CLOCK gene with either the T or C SNP at position 3111. We then measured circadian gene expression over a 24-h time period. We found that the CLOCK3111C SNP resulted in higher mRNA levels than the CLOCK 3111T SNP. Furthermore, we found that Per2, a transcriptional target of CLOCK, was also more highly expressed with CLOCK 3111C expression, indicating that the 3'-UTR SNP affects the expression, function, and stability of CLOCK mRNA. PMID:27148095

  8. Atomic physics

    International Nuclear Information System (INIS)

    Research activities in atomic physics at Lawrence Berkeley Laboratory during 1976 are described. Topics covered include: experiments on stored ions; test for parity violation in neutral weak currents; energy conservation and astrophysics; atomic absorption spectroscopy, atomic and molecular detectors; theoretical studies of quantum electrodynamics and high-z ions; atomic beam magnetic resonance; radiative decay from the 23Po,2 levels of helium-like argon; quenching of the metastable 2S/sub 1/2/ state of hydrogen-like argon in an external electric field; and lifetime of the 23Po level of helium-like krypton

  9. Measurement of an atomic quadrupole moment using dynamic decoupling

    Science.gov (United States)

    Akerman, Nitzan; Shaniv, Ravid; Ozeri, Roee

    2016-05-01

    Some of the best clocks today are ion-based optical clocks. These clocks are referenced to a narrow optical transition in a trapped ion. An example for such a narrow transition is the electric quadrupole E 2 transition between states with identical parity. An important systematic shift of such a transition is the quadrupole shift resulting from the electric field gradient inherent to the ion trap. We present a new dynamic decoupling method that rejects magnetic field noise while measuring the small quadrupole shift of the optical clock transition. Using our sequence we measured the quadrupole moment of the 4D5/2 level in a trapped 88 Sr+ ion to be 2 .973-0 . 033 + 0 . 026 ea02 , where e is the electron charge and a0 is the Bohr radius. Our measurement improves the uncertainty of this value by an order of magnitude and thus helps mitigate an important systematic uncertainty in 88 Sr+ based optical atomic clocks and verifies complicated many-body quantum calculations.

  10. Light scattering from dense cold atomic media

    Science.gov (United States)

    Zhu, Bihui; Cooper, John; Ye, Jun; Rey, Ana Maria

    2016-08-01

    We theoretically study the propagation of light through a cold atomic medium, where the effects of motion, laser intensity, atomic density, and polarization can all modify the properties of the scattered light. We present two different microscopic models: the "coherent dipole model" and the "random-walk model", both suitable for modeling recent experimental work done in large atomic arrays in the low-light-intensity regime. We use them to compute relevant observables such as the linewidth, peak intensity, and line center of the emitted light. We further develop generalized models that explicitly take into account atomic motion. Those are relevant for hotter atoms and beyond the low-intensity regime. We show that atomic motion can lead to drastic dephasing and to a reduction of collective effects, together with a distortion of the line shape. Our results are applicable to model a full gamut of quantum systems that rely on atom-light interactions, including atomic clocks, quantum simulators, and nanophotonic systems.

  11. Pacemaker-neuron-dependent disturbance of the molecular clockwork by a Drosophila CLOCK mutant homologous to the mouse Clock mutation.

    Science.gov (United States)

    Lee, Euna; Cho, Eunjoo; Kang, Doo Hyun; Jeong, Eun Hee; Chen, Zheng; Yoo, Seung-Hee; Kim, Eun Young

    2016-08-16

    Circadian clocks are composed of transcriptional/translational feedback loops (TTFLs) at the cellular level. In Drosophila TTFLs, the transcription factor dCLOCK (dCLK)/CYCLE (CYC) activates clock target gene expression, which is repressed by the physical interaction with PERIOD (PER). Here, we show that amino acids (AA) 657-707 of dCLK, a region that is homologous to the mouse Clock exon 19-encoded region, is crucial for PER binding and E-box-dependent transactivation in S2 cells. Consistently, in transgenic flies expressing dCLK with an AA657-707 deletion in the Clock (Clk(out)) genetic background (p{dClk-Δ};Clk(out)), oscillation of core clock genes' mRNAs displayed diminished amplitude compared with control flies, and the highly abundant dCLKΔ657-707 showed significantly decreased binding to PER. Behaviorally, the p{dClk-Δ};Clk(out) flies exhibited arrhythmic locomotor behavior in the photic entrainment condition but showed anticipatory activities of temperature transition and improved free-running rhythms in the temperature entrainment condition. Surprisingly, p{dClk-Δ};Clk(out) flies showed pacemaker-neuron-dependent alterations in molecular rhythms; the abundance of dCLK target clock proteins was reduced in ventral lateral neurons (LNvs) but not in dorsal neurons (DNs) in both entrainment conditions. In p{dClk-Δ};Clk(out) flies, however, strong but delayed molecular oscillations in temperature cycle-sensitive pacemaker neurons, such as DN1s and DN2s, were correlated with delayed anticipatory activities of temperature transition. Taken together, our study reveals that the LNv molecular clockwork is more sensitive than the clockwork of DNs to dysregulation of dCLK by AA657-707 deletion. Therefore, we propose that the dCLK/CYC-controlled TTFL operates differently in subsets of pacemaker neurons, which may contribute to their specific functions. PMID:27489346

  12. Atomic physics

    CERN Document Server

    Born, Max

    1989-01-01

    The Nobel Laureate's brilliant exposition of the kinetic theory of gases, elementary particles, the nuclear atom, wave-corpuscles, atomic structure and spectral lines, electron spin and Pauli's principle, quantum statistics, molecular structure and nuclear physics. Over 40 appendices, a bibliography, numerous figures and graphs.

  13. Protecting Clock Synchronization: Adversary Detection through Network Monitoring

    Directory of Open Access Journals (Sweden)

    Elena Lisova

    2016-01-01

    Full Text Available Nowadays, industrial networks are often used for safety-critical applications with real-time requirements. Such applications usually have a time-triggered nature with message scheduling as a core property. Scheduling requires nodes to share the same notion of time, that is, to be synchronized. Therefore, clock synchronization is a fundamental asset in real-time networks. However, since typical standards for clock synchronization, for example, IEEE 1588, do not provide the required level of security, it raises the question of clock synchronization protection. In this paper, we identify a way to break synchronization based on the IEEE 1588 standard, by conducting a man-in-the-middle (MIM attack followed by a delay attack. A MIM attack can be accomplished through, for example, Address Resolution Protocol (ARP poisoning. Using the AVISPA tool, we evaluate the potential to perform a delay attack using ARP poisoning and analyze its consequences showing both that the attack can, indeed, break clock synchronization and that some design choices, such as a relaxed synchronization condition mode, delay bounding, and using knowledge of environmental conditions, can make the network more robust/resilient against these kinds of attacks. Lastly, a Configuration Agent is proposed to monitor and detect anomalies introduced by an adversary performing attacks targeting clock synchronization.

  14. Energy Efficient Global Clock Synchronization for Wireless Sensor Networks

    Directory of Open Access Journals (Sweden)

    Vinod Namboodiri

    2010-05-01

    Full Text Available Clock synchronization is critical to many sensor networks for the success of the application as well as energyefficiency. Achieving a global time frame through localized averaging of clock values for multiple rounds till convergenceis a promising approach to clock synchronization due to the decentralized nature of computation coupled withscalability. However, it is not clear what power levels for all nodes would make the synchronization process energyefficient.Large power levels lead to faster convergence but consume a lot of energy per round of synchronization.On the other hand, smaller powers consume little energy per round, but convergence is very slow requiring a lotof rounds to achieve synchronization. In this paper we look at the problem of finding a power assignment thatachieves global clock synchronization in the most energy-efficient manner possible. We look at the problem throughtwo dimensions; rate of convergence and energy consumed per round of synchronization. A centralized algorithm ispresented that uses the path congestion of the induced communication graph to estimate which power assignmentshave good convergence properties and find one that minimizes the total energy to achieve clock synchronization.Our evaluation demonstrates that the power assignment derived from this algorithm is very energy-efficient and isapplicable for wireless communication environments with various distance-power gradients. Further, we present asimple distributed algorithm which nodes can execute locally to derive energy-efficient power levels for global clocksynchronization, and is especially useful in large-scale deployments.

  15. Buffer Gas Experiments in Mercury (Hg+) Ion Clock

    Science.gov (United States)

    Chung, Sang K.; Prestage, John D.; Tjoelker, Robert L.; Maleki, Lute

    2004-01-01

    We describe the results of the frequency shifts measured from various buffer gases that might be used as a buffer gas to increase the loading efficiency and cooling of ions trapped in a small mercury ion clock. The small mass, volume and power requirement of space clock precludes the use of turbo pumps. Hence, a hermetically sealed vacuum system, incorporating a suitable getter material with a fixed amount of inert buffer gas may be a practical alternative to the groundbased system. The collision shifts of 40,507,347.996xx Hz clock transition for helium, neon and argon buffer gases were measured in the ambient earth magnetic field. In addition to the above non-getterable inert gases we also measured the frequency shifts due to getterable, molecular hydrogen and nitrogen gases which may be used as buffer gases when incorporated with a miniature ion pump. We also examined the frequency shift due to the low methane gas partial pressure in a fixed higher pressure neon buffer gas environment. Methane gas interacted with mercury ions in a peculiar way as to preserve the ion number but to relax the population difference in the two hyperfine clock states and thereby reducing the clock resonance signal. The same population relaxation was also observed for other molecular buffer gases (N H,) but at much reduced rate.

  16. Differentially timed extracellular signals synchronize pacemaker neuron clocks.

    Directory of Open Access Journals (Sweden)

    Ben Collins

    2014-09-01

    Full Text Available Synchronized neuronal activity is vital for complex processes like behavior. Circadian pacemaker neurons offer an unusual opportunity to study synchrony as their molecular clocks oscillate in phase over an extended timeframe (24 h. To identify where, when, and how synchronizing signals are perceived, we first studied the minimal clock neural circuit in Drosophila larvae, manipulating either the four master pacemaker neurons (LNvs or two dorsal clock neurons (DN1s. Unexpectedly, we found that the PDF Receptor (PdfR is required in both LNvs and DN1s to maintain synchronized LNv clocks. We also found that glutamate is a second synchronizing signal that is released from DN1s and perceived in LNvs via the metabotropic glutamate receptor (mGluRA. Because simultaneously reducing Pdfr and mGluRA expression in LNvs severely dampened Timeless clock protein oscillations, we conclude that the master pacemaker LNvs require extracellular signals to function normally. These two synchronizing signals are released at opposite times of day and drive cAMP oscillations in LNvs. Finally we found that PdfR and mGluRA also help synchronize Timeless oscillations in adult s-LNvs. We propose that differentially timed signals that drive cAMP oscillations and synchronize pacemaker neurons in circadian neural circuits will be conserved across species.

  17. A high-precision synchronization circuit for clock distribution

    International Nuclear Information System (INIS)

    In this paper, a novel structure of a high-precision synchronization circuit, HPSC, using interleaved delay units and a dynamic compensation circuit is proposed. HPSCs are designed for synchronization of clock distribution networks in large-scale integrated circuits, where high-quality clocks are required. The application of a hybrid structure of a coarse delay line and dynamic compensation circuit performs roughly the alignment of the clock signal in two clock cycles, and finishes the fine tuning in the next three clock cycles with the phase error suppressed under 3.8 ps. The proposed circuit is implemented and fabricated using a SMIC 0.13 μm 1P6M process with a supply voltage at 1.2 V. The allowed operation frequency ranges from 200 to 800 MHz, and the duty cycle ranges between [20%, 80%]. The active area of the core circuits is 245 × 134 μm2, and the power consumption is 1.64 mW at 500 MHz. (paper)

  18. The circadian molecular clock creates epidermal stem cell heterogeneity.

    Science.gov (United States)

    Janich, Peggy; Pascual, Gloria; Merlos-Suárez, Anna; Batlle, Eduard; Ripperger, Jürgen; Albrecht, Urs; Cheng, Hai-Ying M; Obrietan, Karl; Di Croce, Luciano; Benitah, Salvador Aznar

    2011-11-09

    Murine epidermal stem cells undergo alternate cycles of dormancy and activation, fuelling tissue renewal. However, only a subset of stem cells becomes active during each round of morphogenesis, indicating that stem cells coexist in heterogeneous responsive states. Using a circadian-clock reporter-mouse model, here we show that the dormant hair-follicle stem cell niche contains coexisting populations of cells at opposite phases of the clock, which are differentially predisposed to respond to homeostatic cues. The core clock protein Bmal1 modulates the expression of stem cell regulatory genes in an oscillatory manner, to create populations that are either predisposed, or less prone, to activation. Disrupting this clock equilibrium, through deletion of Bmal1 (also known as Arntl) or Per1/2, resulted in a progressive accumulation or depletion of dormant stem cells, respectively. Stem cell arrhythmia also led to premature epidermal ageing, and a reduction in the development of squamous tumours. Our results indicate that the circadian clock fine-tunes the temporal behaviour of epidermal stem cells, and that its perturbation affects homeostasis and the predisposition to tumorigenesis.

  19. Autonomous Rubidium Clock Weak Frequency Jump Detector for Onboard Navigation Satellite System.

    Science.gov (United States)

    Khare, Akshay; Arora, Rajat; Banik, Alak; Mehta, Sanjay D

    2016-02-01

    Frequency jumps are common in rubidium frequency sources. They affect the estimation of user position in navigational satellite systems. These jumps must be detected and corrected immediately as they have direct impact on the navigation system integrity. A novel weak frequency jump detector is proposed based on a Kalman filter with a multi-interval approach. This detector can be applied for both "sudden" and "slow" frequency transitions. In this detection method, noises of clock data are reduced by Kalman filtering, for accurate estimation of jump size with less latency. Analysis on in-orbit rubidium atomic frequency standard (RAFS) phase telemetry data shows that the detector can be used for fast detection and correction of weak frequency jumps. Furthermore, performance comparison of different existing frequency jump detection techniques with the proposed detector is discussed. A multialgorithm-based strategy is proposed depending on the jump size and latency for onboard navigation satellites having RAFS as the primary frequency source.

  20. Autonomous Rubidium Clock Weak Frequency Jump Detector for Onboard Navigation Satellite System.

    Science.gov (United States)

    Khare, Akshay; Arora, Rajat; Banik, Alak; Mehta, Sanjay D

    2016-02-01

    Frequency jumps are common in rubidium frequency sources. They affect the estimation of user position in navigational satellite systems. These jumps must be detected and corrected immediately as they have direct impact on the navigation system integrity. A novel weak frequency jump detector is proposed based on a Kalman filter with a multi-interval approach. This detector can be applied for both "sudden" and "slow" frequency transitions. In this detection method, noises of clock data are reduced by Kalman filtering, for accurate estimation of jump size with less latency. Analysis on in-orbit rubidium atomic frequency standard (RAFS) phase telemetry data shows that the detector can be used for fast detection and correction of weak frequency jumps. Furthermore, performance comparison of different existing frequency jump detection techniques with the proposed detector is discussed. A multialgorithm-based strategy is proposed depending on the jump size and latency for onboard navigation satellites having RAFS as the primary frequency source. PMID:26685233

  1. Secondary laser cooling of strontium-88 atoms

    Energy Technology Data Exchange (ETDEWEB)

    Strelkin, S. A.; Khabarova, K. Yu., E-mail: kseniakhabarova@gmail.com; Galyshev, A. A.; Berdasov, O. I.; Gribov, A. Yu.; Kolachevsky, N. N.; Slyusarev, S. N. [Federal State Unitary Enterprise “All-Russia Research Institute for Physicotechnical and Radio Engineering Measurements” (VNIIFTRI) (Russian Federation)

    2015-07-15

    The secondary laser cooling of a cloud of strontium-88 atoms on the {sup 1}S{sub 0}–{sup 3}P{sub 1} (689 nm) intercombination transition captured into a magneto-optical trap has been demonstrated. We describe in detail the recapture of atoms from the primary trap operating on the strong {sup 1}S{sub 0}–{sup 1}P{sub 1} (461 nm) transition and determine the recapture coefficient κ, the number of atoms, and their temperature in the secondary trap as a function of experimental parameters. A temperature of 2 µK has been reached in the secondary trap at the recapture coefficient κ = 6%, which confirms the secondary cooling efficiency and is sufficient to perform metrological measurements of the {sup 1}S{sub 0}–{sup 3}P{sub 1} (698 nm) clock transition in an optical lattice.

  2. Fault-tolerant clock synchronization validation methodology. [in computer systems

    Science.gov (United States)

    Butler, Ricky W.; Palumbo, Daniel L.; Johnson, Sally C.

    1987-01-01

    A validation method for the synchronization subsystem of a fault-tolerant computer system is presented. The high reliability requirement of flight-crucial systems precludes the use of most traditional validation methods. The method presented utilizes formal design proof to uncover design and coding errors and experimentation to validate the assumptions of the design proof. The experimental method is described and illustrated by validating the clock synchronization system of the Software Implemented Fault Tolerance computer. The design proof of the algorithm includes a theorem that defines the maximum skew between any two nonfaulty clocks in the system in terms of specific system parameters. Most of these parameters are deterministic. One crucial parameter is the upper bound on the clock read error, which is stochastic. The probability that this upper bound is exceeded is calculated from data obtained by the measurement of system parameters. This probability is then included in a detailed reliability analysis of the system.

  3. Circadian clocks optimally adapt to sunlight for reliable synchronization

    CERN Document Server

    Hasegawa, Yoshihiko

    2014-01-01

    Circadian oscillation provides selection advantages through synchronization to the daylight cycle. However, a reliable clock must be designed through two conflicting properties: entrainability to properly respond to external stimuli such as sunlight, and regularity to oscillate with a precise period. These two aspects do not easily coexist because better entrainability favors higher sensitivity, which may sacrifice the regularity. To investigate conditions for satisfying the two properties, we analytically calculated the optimal phase-response curve with a variational method. Our result indicates an existence of a dead zone, i.e., a time during which external stimuli neither advance nor delay the clock. This result is independent of model details and a dead zone appears only when the input stimuli obey the time course of actual insolation. Our calculation demonstrates that every circadian clock with a dead zone is optimally adapted to the daylight cycle. Our result also explains the lack of a dead zone in osc...

  4. ‘Leading clocks lag’ and the de Broglie wavelength

    Science.gov (United States)

    Shuler, Robert L., Jr.

    2016-03-01

    The forgotten history of de Broglie waves as themselves artifacts of a Lorentz transform, not physical lengths and frequencies to be transformed, causes confusion for students and others. In this paper the de Broglie wavelength is derived and dependence of de Broglie frequency on velocity explained in terms of Einstein synchronized reference frame measurements of a single clock (2-on-1) versus measurements of an Einstein reference frame by an observer with a single clock (1-on-2). A new memory aid for the relativity of simultaneity, ‘leading clocks lag,’ is introduced that puts it on a par with the heuristics ‘time dilation’ and ‘length contraction’ for quick and easy problem visualization.

  5. The twin paradox with macroscopic clocks in superconducting circuits

    CERN Document Server

    Lindkvist, Joel; Fuentes, Ivette; Dragan, Andrzej; Svensson, Ida-Maria; Delsing, Per; Johansson, Göran

    2014-01-01

    Time dilation, a striking prediction of Einstein's relativity, plays an important role in applications such as the Global Positioning System. One of the most compelling consequences of time dilation is known as the twin paradox, where a twin at rest ages more than her sibling travelling at relativistic speeds. In this paper, we propose an implementation of the twin paradox in superconducting circuits with velocities as large as a few percent of the speed of light. Ultrafast modulation of the boundary conditions for the electromagnetic field in a microwave cavity simulates a clock moving at relativistic speeds. While previous demonstrations of this effect involve point-like clocks, our superconducting cavity has a finite length, allowing us to investigate the role of clock size as well as interesting quantum effects on time dilation. In particular, our theoretical results show that the travelling twin ages slower for larger cavity lengths and that quantum particle creation, known in this context as the dynamic...

  6. Event-Clock Automata: From Theory to Practice

    CERN Document Server

    Geeraerts, Gilles; Sznajder, Nathalie

    2011-01-01

    Event clock automata (ECA) are a model for timed languages that has been introduced by Alur, Fix and Henzinger as an alternative to timed automata, with better theoretical properties (for instance, ECA are determinizable while timed automata are not). In this paper, we revisit and extend the theory of ECA. We first prove that no finite time abstract language equivalence exists for ECA, thereby disproving a claim in the original work on ECA. This means in particular that regions do not form a time abstract bisimulation. Nevertheless, we show that regions can still be used to build a finite automaton recognizing the untimed language of an ECA. Then, we extend the classical notions of zones and DBMs to let them handle event clocks instead of plain clocks (as in timed automata) by introducing event zones and Event DBMs (EDBMs). We discuss algorithms to handle event zones represented as EDBMs, as well as (semi-) algorithms based on EDBMs to decide language emptiness of ECA.

  7. Fault Secure Encoder and Decoder with Clock Gating

    Directory of Open Access Journals (Sweden)

    N.Kapileswar

    2012-04-01

    Full Text Available This paper presents circuit design for a low power fault secure encoder and decoder system. Memory cells in logic circuits have been protected from soft errors for more than a decade due to increase in soft error rates. In this paper the circuitry around the memory block have been susceptible to soft errors and must be protected from faults. The proposed design uses error correcting codes and ring counter addressing scheme. In the ring counter several new clock gating techniques are proposed to reduce power consumption. A fault secure Encoder and Decoder error free low power logic circuits can be achieved by the proposed design. Simulation results show great improvement in power consumption. Fault secure Encoder and Decoder with clock gated by CG-element consumes approximately half the power of that consumed by the fault free circuit which doesn’t employ clock gating technique

  8. Revisiting a Classic Study of the Molecular Clock.

    Science.gov (United States)

    Robinson, Lauren M; Boland, Joseph R; Braverman, John M

    2016-03-01

    A constant rate of molecular evolution among homologous proteins and across lineages is known as the molecular clock. This concept has been useful for estimating divergence times. Here, we revisit a study by Richard Dickerson (J Mol Evol 1:26-45, 1971), wherein he provided striking visual evidence for a constant rate of amino acid changes among various evolutionary branch points. Dickerson's study is commonly cited as support of the molecular clock and a figure from it is often reproduced in textbooks. Since its publication, however, there have been updates made to dates of common ancestors based on the fossil record that should be considered. Additionally, collecting the accession numbers and carefully outlining Dickerson's methods serves as a resource to students of the molecular clock hypothesis.

  9. Multi-GNSS Orbit and Clock Combination: Preliminary Results

    Science.gov (United States)

    Fritsche, Mathias

    2016-04-01

    In the framework of the Multi-GNSS Experiment (MGEX) a number of Analysis Centers (ACs) extended their software capabilities to process signals from the BeiDou, Galileo, and QZSS systems in addition to the well established systems GPS and GLONASS. Currently, the MGEX product portfolio covers precise satellite orbits and clocks, receiver clocks, signal biases, and Earth rotation parameters generated by the individual ACs. This presentation will provide an overview on the available AC-specific MGEX products. In addition, an introduction to a multi-GNSS orbit and clock combination procedure will be given. Finally, preliminary results from that multi-GNSS combination including a comparison with corresponding operational IGS products will be reported along with a discussion of the results.

  10. Progress on a Miniature Cold-Atom Frequency Standard

    CERN Document Server

    Scherer, David R; Mescher, Mark; Stoner, Richard; Timmons, Brian; Rogomentich, Fran; Tepolt, Gary; Mahnkopf, Sven; Noble, Jay; Chang, Sheng; Taylor, Dwayne

    2014-01-01

    Atomic clocks play a crucial role in timekeeping, communications, and navigation systems. Recent efforts enabled by heterogeneous MEMS integration have led to the commercial introduction of Chip-Scale Atomic Clocks (CSAC) with a volume of 16 cm3, power consumption of 120 mW, and instability (Allan Deviation) of {\\sigma}({\\tau} = 1 sec) < 2e-10. In order to reduce the temperature sensitivity of next-generation CSACs for timing applications, the interaction of atoms with the environment must be minimized, which can be accomplished in an architecture based on trapped, laser-cooled atoms. In this paper, we present results describing the development of a miniature cold-atom apparatus for operation as a frequency standard. Our architecture is based on laser-cooling a sample of neutral atoms in a Magneto-Optical Trap (MOT) using a conical retro-reflector in a miniature vacuum chamber. Trapping the atoms in vacuum and performing microwave interrogation in the dark reduces the temperature sensitivity compared to va...

  11. General flat four-dimensional world pictures and clock systems

    Science.gov (United States)

    Hsu, J. P.; Underwood, J. A.

    1978-01-01

    We explore the mathematical structure and the physical implications of a general four-dimensional symmetry framework which is consistent with the Poincare-Einstein principle of relativity for physical laws and with experiments. In particular, we discuss a four-dimensional framework in which all observers in different frames use one and the same grid of clocks. The general framework includes special relativity and a recently proposed new four-dimensional symmetry with a nonuniversal light speed as two special simple cases. The connection between the properties of light propagation and the convention concerning clock systems is also discussed, and is seen to be nonunique within the four-dimensional framework.

  12. Methods to study the mechanism of the Neurospora Circadian Clock

    Science.gov (United States)

    Cha, Joonseok; Zhou, Mian; Liu, Yi

    2015-01-01

    Eukaryotic circadian clocks are comprised of interlocked auto-regulatory feedback loops that control gene expression at the levels of transcription and translation. The filamentous fungus Neurospora crassa is an excellent model for the complex molecular network of regulatory mechanisms that are common to all eukaryotes. In the heart of the network, post-translational regulations and functions of the core clock elements are of major interest. This chapter will discuss the methods that were recently used to study the Neurospora circadian oscillator mechanisms at the molecular level. PMID:25662455

  13. THE STOCHASTIC ESTIMATION OF SATELLITE CLOCK CORRECTION INFORMATION IN WADGPS

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    Using autocorrelation information of the pseudorange errors generated by se lective availability (SA) frequency dithering, we have constructed a simple first order stochas tic model for SA effects. This model has been used in a Kalman filter to account for the stochastic behavior of SA dithering in estimating satellite clock information in wide area dif ferential GPS. We have obtained fifteen percent improvement in the user positioning using the correlation information on the satellite clock information in a Kalman filter, when comparing the results obtained using a regular least square estimation.

  14. Illuminating the circadian clock in monarch butterfly migration.

    Science.gov (United States)

    Froy, Oren; Gotter, Anthony L; Casselman, Amy L; Reppert, Steven M

    2003-05-23

    Migratory monarch butterflies use a time-compensated Sun compass to navigate to their overwintering grounds in Mexico. Here, we report that constant light, which disrupts circadian clock function at both the behavioral and molecular levels in monarchs, also disrupts the time-compensated component of flight navigation. We further show that ultraviolet light is important for flight navigation but is not required for photic entrainment of circadian rhythms. Tracing these distinct light-input pathways into the brain should aid our understanding of the clock-compass mechanisms necessary for successful migration. PMID:12764200

  15. Nuclear clocks based on resonant excitation of gamma-transitions

    CERN Document Server

    Peik, Ekkehard

    2015-01-01

    We review the ideas and concepts for a clock that is based on a radiative transition in the nucleus rather than in the electron shell. This type of clock offers advantages like an insensitivity against field-induced systematic frequency shifts and the opportunity to obtain high stability from interrogating many nuclei in the solid state. Experimental work concentrates on the low-energy (about 8 eV) isomeric transition in Th-229. We review the status of the experiments that aim at a direct optical observation of this transition and outline the plans for high-resolution laser spectroscopy experiments.

  16. Nuclear clocks based on resonant excitation of gamma-transitions

    OpenAIRE

    Peik, Ekkehard; Okhapkin, Maxim

    2015-01-01

    We review the ideas and concepts for a clock that is based on a radiative transition in the nucleus rather than in the electron shell. This type of clock offers advantages like an insensitivity against field-induced systematic frequency shifts and the opportunity to obtain high stability from interrogating many nuclei in the solid state. Experimental work concentrates on the low-energy (about 8 eV) isomeric transition in Th-229. We review the status of the experiments that aim at a direct opt...

  17. Reference clock parameters for digital communications systems applications

    Science.gov (United States)

    Kartaschoff, P.

    1981-01-01

    The basic parameters relevant to the design of network timing systems describe the random and systematic time departures of the system elements, i.e., master (or reference) clocks, transmission links, and other clocks controlled over the links. The quantitative relations between these parameters were established and illustrated by means of numerical examples based on available measured data. The examples were limited to a simple PLL control system but the analysis can eventually be applied to more sophisticated systems at the cost of increased computational effort.

  18. Timing Jitter Analysis for Clock recovery Circuits Based on an Optoelectronic Phase-Locked Loop (OPLL)

    DEFF Research Database (Denmark)

    Zibar, Darko; Mørk, Jesper; Oxenløwe, Leif Katsuo;

    2005-01-01

    Timing jitter of an OPLL based clock recovery is investigated. We demonstrate how loop gain, input and VCO signal jitter, loop filter bandwidth and a loop time delay influence jitter of the extracted clock signal...

  19. Generating clock signals for a cycle accurate, cycle reproducible FPGA based hardware accelerator

    Science.gov (United States)

    Asaad, Sameth W.; Kapur, Mohit

    2016-01-05

    A method, system and computer program product are disclosed for generating clock signals for a cycle accurate FPGA based hardware accelerator used to simulate operations of a device-under-test (DUT). In one embodiment, the DUT includes multiple device clocks generating multiple device clock signals at multiple frequencies and at a defined frequency ratio; and the FPG hardware accelerator includes multiple accelerator clocks generating multiple accelerator clock signals to operate the FPGA hardware accelerator to simulate the operations of the DUT. In one embodiment, operations of the DUT are mapped to the FPGA hardware accelerator, and the accelerator clock signals are generated at multiple frequencies and at the defined frequency ratio of the frequencies of the multiple device clocks, to maintain cycle accuracy between the DUT and the FPGA hardware accelerator. In an embodiment, the FPGA hardware accelerator may be used to control the frequencies of the multiple device clocks.

  20. Circadian Clock genes Per2 and clock regulate steroid production, cell proliferation, and luteinizing hormone receptor transcription in ovarian granulosa cells

    Energy Technology Data Exchange (ETDEWEB)

    Shimizu, Takashi, E-mail: shimizut@obihiro.ac.jp [Graduate School of Animal and Food Hygiene, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555 (Japan); Hirai, Yuko; Murayama, Chiaki; Miyamoto, Akio [Graduate School of Animal and Food Hygiene, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555 (Japan); Miyazaki, Hitoshi [Gene Research Center, University of Tsukuba, Tsukuba, Ibaraki 305-8572 (Japan); Miyazaki, Koyomi [Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology (AIST) Central 6, 1-1-1, Higashi, Tsukuba, Ibaraki 305-8566 (Japan)

    2011-08-19

    Highlights: {yields} Treatment with Per2 and Clock siRNAs decreased the number of granulosa cells and LHr expression. {yields}Per2 siRNA treatment did not stimulate the production of estradiol and expression of P450arom. {yields} Clock siRNA treatment inhibited the production of estradiol and expression of P450arom mRNA. {yields}Per2 and Clock siRNA treatment increased and unchanged, respectively, progesterone production in FSH-treated granulosa cells. {yields} The expression of StAR mRNA was increased by Per2 siRNA and unchanged by Clock siRNA. -- Abstract: Circadian Clock genes are associated with the estrous cycle in female animals. Treatment with Per2 and Clock siRNAs decreased the number of granulosa cells and LHr expression in follicle-stimulating hormone FSH-treated granulosa cells. Per2 siRNA treatment did not stimulate the production of estradiol and expression of P450arom, whereas Clock siRNA treatment inhibited the production of estradiol and expression of P450arom mRNA. Per2 and Clock siRNA treatment increased and unchanged, respectively, progesterone production in FSH-treated granulosa cells. Similarly, expression of StAR mRNA was increased by Per2 siRNA and unchanged by Clock siRNA. Our data provide a new insight that Per2 and Clock have different action on ovarian granulosa cell functions.

  1. Oscillating perceptions: the ups and downs of the CLOCK protein in the mouse circadian system

    Indian Academy of Sciences (India)

    Jason P. Debruyne

    2008-12-01

    A functional mouse CLOCK protein has long been thought to be essential for mammalian circadian clockwork function, based mainly on studies of mice bearing a dominant negative, antimorphic mutation in the Clock gene. However, new discoveries using recently developed Clock-null mutant mice have shaken up this view. In this review, I discuss how this recent work impacts and alters the previous view of the role of CLOCK in the mouse circadian clockwork.

  2. System and method for clock synchronization and position determination using entangled photon pairs

    Science.gov (United States)

    Shih, Yanhua (Inventor)

    2010-01-01

    A system and method for clock synchronization and position determination using entangled photon pairs is provided. The present invention relies on the measurement of the second order correlation function of entangled states. Photons from an entangled photon source travel one-way to the clocks to be synchronized. By analyzing photon registration time histories generated at each clock location, the entangled states allow for high accuracy clock synchronization as well as high accuracy position determination.

  3. All-optical clock recovery of NRZ-DPSK signals using optical resonator-type filters

    DEFF Research Database (Denmark)

    Peucheret, Christophe; Seoane, Jorge; Ji, Hua

    2009-01-01

    It is shown how introducing a limited rise time to the driving signal enables all-optical clock recovery of NRZ-DPSK signals generated using a phase modulator. A Fabry-Perot filter is used to generate the optical clock.......It is shown how introducing a limited rise time to the driving signal enables all-optical clock recovery of NRZ-DPSK signals generated using a phase modulator. A Fabry-Perot filter is used to generate the optical clock....

  4. Altered expression pattern of clock genes in a rat model of depression

    DEFF Research Database (Denmark)

    Christiansen, Sofie; Bouzinova, Elena; Fahrenkrug, Jan;

    2016-01-01

    of clock gene expression in depressive patients many studies have reported single-nucleotide polymorphisms in clock genes in these patients. METHODS: In the present study we investigated whether a depression-like state in rats associates with alternations of the diurnal expression of clock genes......: The present results suggest that altered expression of investigated clock genes are likely to associate with the induction of a depression-like state in the CMS model...

  5. Telling time from analog and digital clocks: A multiple-route account

    NARCIS (Netherlands)

    Korvorst, M.H.W.; Roelofs, A.P.A.; Levelt, W.J.M.

    2007-01-01

    Does the naming of clocks always require conceptual preparation? To examine this question, speakers were presented with analog and digital clocks that had to be named in Dutch using either a relative (e.g., "quarter to four") or an absolute (e.g., "three forty-five") clock time expression format. Na

  6. CRY Drives Cyclic CK2-Mediated BMAL1 Phosphorylation to Control the Mammalian Circadian Clock

    NARCIS (Netherlands)

    T. Tamaru (Teruya); M. Hattori (Mitsuru); K. Honda (Kousuke); Y. Nakahata (Yasukazu); P. Sassone-Corsi (Paolo); G.T.J. van der Horst (Gijsbertus); T. Ozawa (Takeaki); K. Takamatsu (Ken)

    2015-01-01

    textabstractIntracellular circadian clocks, composed of clock genes that act in transcription-translation feedback loops, drive global rhythmic expression of the mammalian transcriptome and allow an organism to anticipate to the momentum of the day. Using a novel clock-perturbing peptide, we establi

  7. Regulation of behavioral circadian rhythms and clock protein PER1 by the deubiquitinating enzyme USP2

    Directory of Open Access Journals (Sweden)

    Yaoming Yang

    2012-06-01

    Endogenous 24-hour rhythms are generated by circadian clocks located in most tissues. The molecular clock mechanism is based on feedback loops involving clock genes and their protein products. Post-translational modifications, including ubiquitination, are important for regulating the clock feedback mechanism. Previous work has focused on the role of ubiquitin ligases in the clock mechanism. Here we show a role for the rhythmically-expressed deubiquitinating enzyme ubiquitin specific peptidase 2 (USP2 in clock function. Mice with a deletion of the Usp2 gene (Usp2 KO display a longer free-running period of locomotor activity rhythms and altered responses of the clock to light. This was associated with altered expression of clock genes in synchronized Usp2 KO mouse embryonic fibroblasts and increased levels of clock protein PERIOD1 (PER1. USP2 can be coimmunoprecipitated with several clock proteins but directly interacts specifically with PER1 and deubiquitinates it. Interestingly, this deubiquitination does not alter PER1 stability. Taken together, our results identify USP2 as a new core component of the clock machinery and demonstrate a role for deubiquitination in the regulation of the circadian clock, both at the level of the core pacemaker and its response to external cues.

  8. Representing the object of controversy: the case of the molecular clock.

    Science.gov (United States)

    Dietrich, Michael R

    2007-01-01

    Through a case study of the controversies surrounding the molecular clock, this paper examines the role of visual representation in the dynamics of scientific controversies. Representations of the molecular clock themselves became objects of controversy and so were not a means for closure. Instead visual representations of the molecular clock became tools for the further articulation of an ongoing controversy.

  9. Precision spectroscopy on atomic hydrogen

    Energy Technology Data Exchange (ETDEWEB)

    Parthey, Christian Godehard

    2011-12-15

    This Thesis reports on three measurements involving the 1S-2S transition in atomic hydrogen and deuterium conducted on a 5.8 K atomic beam. The transition is excited Doppler-free via two counter-propagating photons near 243 nm. The H/D isotope shift has been determined as {delta}{integral}{sub exp}=670 994 334 606(15) Hz. Comparing with the theoretical value for the isotope shift, excluding the leading nuclear size effect, {delta}{integral}{sub th}=670 999 566.90(66)(60) kHz we confirm, twice more accurate, the rms charge radius difference of the deuteron and the proton as left angle r{sup 2} right angle {sub d}- left angle r{sup 2} right angle {sub p}=3.82007(65) fm{sup 2} and the deuteron structure radius r{sub str}=1.97507(78) fm. The frequency ratio of the 1S-2S transition in atomic hydrogen to the cesium ground state hyperfine transition provided by the mobile cesium fountain clock FOM is measured to be {integral}{sub 1S-2S}=2 466 061 413 187 035 (10) Hz which presents a fractional frequency uncertainty of 4.2 x 10{sup -15}. The second absolute frequency measurement of the 1S-2S transition in atomic hydrogen presents the first application of a 900 km fiber link between MPQ and Physikalisch- Technische Bundesanstalt (PTB) in Braunschweig which we have used to calibrate the MPQ hydrogen maser with the stationary cesium fountain clock CSF1 at PTB. With the result of {integral}{sub 1S-2S}=2 466 061 413 187 017 (11) Hz we can put a constraint on the electron Lorentz boost violating coefficients 0.95c{sub (TX)}-0.29c{sub (TY)}-0.08 c{sub (TZ)}=(2.2{+-}1.8) x 10{sup -11} within the framework of minimal standard model extensions. We limit a possible drift of the strong coupling constant through the ratio of magnetic moments at a competitive level ({partial_derivative})/({partial_derivative}t)ln ({mu}{sub Cs})/({mu}{sub B})=-(3.0{+-}1.2) x 10{sup -15} yr{sup -1}.

  10. Precision spectroscopy on atomic hydrogen

    International Nuclear Information System (INIS)

    This Thesis reports on three measurements involving the 1S-2S transition in atomic hydrogen and deuterium conducted on a 5.8 K atomic beam. The transition is excited Doppler-free via two counter-propagating photons near 243 nm. The H/D isotope shift has been determined as Δ∫exp=670 994 334 606(15) Hz. Comparing with the theoretical value for the isotope shift, excluding the leading nuclear size effect, Δ∫th=670 999 566.90(66)(60) kHz we confirm, twice more accurate, the rms charge radius difference of the deuteron and the proton as left angle r2 right angle d- left angle r2 right angle p=3.82007(65) fm2 and the deuteron structure radius rstr=1.97507(78) fm. The frequency ratio of the 1S-2S transition in atomic hydrogen to the cesium ground state hyperfine transition provided by the mobile cesium fountain clock FOM is measured to be ∫1S-2S=2 466 061 413 187 035 (10) Hz which presents a fractional frequency uncertainty of 4.2 x 10-15. The second absolute frequency measurement of the 1S-2S transition in atomic hydrogen presents the first application of a 900 km fiber link between MPQ and Physikalisch- Technische Bundesanstalt (PTB) in Braunschweig which we have used to calibrate the MPQ hydrogen maser with the stationary cesium fountain clock CSF1 at PTB. With the result of ∫1S-2S=2 466 061 413 187 017 (11) Hz we can put a constraint on the electron Lorentz boost violating coefficients 0.95c(TX)-0.29c(TY)-0.08 c(TZ)=(2.2±1.8) x 10-11 within the framework of minimal standard model extensions. We limit a possible drift of the strong coupling constant through the ratio of magnetic moments at a competitive level (∂)/(∂t)ln (μCs)/(μB)=-(3.0±1.2) x 10-15 yr-1.

  11. The Brazilian time and frequency atomic standards program

    Directory of Open Access Journals (Sweden)

    Mushtaq Ahmed

    2008-06-01

    Full Text Available Cesium atomic beam clocks have been the workhorse for many demanding applications in science and technology for the past four decades. Tests of the fundamental laws of physics and the search for minute changes in fundamental constants, the synchronization of telecommunication networks, and realization of the satellite-based global positioning system would not be possible without atomic clocks. The adoption of optical cooling and trapping techniques, has produced a major advance in atomic clock precision. Cold-atom fountain and compact cold-atom clocks have also been developed. Measurement precision of a few parts in 10(15 has been demonstrated for a cold-atom fountain clock. We present here an overview of the time and frequency metrology program based on cesium atoms under development at USP São Carlos. This activity consists of construction and characterization of atomic-beam, and several variations of cold-atom clocks. We discuss the basic working principles, construction, evaluation, and important applications of atomic clocks in the Brazilian program.Relógios atômicos de feixe de Césio têm sido a base para diversas aplicações em ciência e tecnologia nas últimas quatro décadas. Testes de leis fundamentais de física, buscas por mínimas variações em constantes fundamentais, sincronização de redes de telecomunicações e o funcionamento do sistema de posicionamento global, baseado em satélites de navegação, não seriam possíveis sem os relógios atômicos. A adoção de técnicas de aprisionamento e resfriamento ópticos tem permitido um grande avanço na precisão dos relógios atômicos. Chafarizes de átomos frios e relógios compactos de átomos frios também têm sido desenvolvidos. Precisões de medida de algumas partes em 1015 foram demonstradas para relógios do tipo chafariz de átomos frios. Apresentamos uma visão geral do programa de metrologia de tempo e freqüência baseado em átomos de césio, em

  12. Towards Relativistic Atomic Physics and Post-Minkowskian Gravitational Waves

    OpenAIRE

    Luca LusannaINFN

    2009-01-01

    A review is given of the formulation of relativistic atomic theory, in which there is an explicit realization of the Poincare' generators, both in the inertial and in the non-inertial rest-frame instant form of dynamics in Minkowski space-time. This implies the need to solve the problem of the relativistic center of mass of an isolated system and to describe the transitions from different conventions for clock synchronization, namely for the identifications of instantaneous ...

  13. Altered circadian clock gene expression in patients with schizophrenia.

    Science.gov (United States)

    Johansson, Anne-Sofie; Owe-Larsson, Björn; Hetta, Jerker; Lundkvist, Gabriella B

    2016-07-01

    Impaired circadian rhythmicity has been reported in several psychiatric disorders. Schizophrenia is commonly associated with aberrant sleep-wake cycles and insomnia. It is not known if schizophrenia is associated with disturbances in molecular rhythmicity. We cultured fibroblasts from skin samples obtained from patients with chronic schizophrenia and from healthy controls, respectively, and analyzed the circadian expression during 48h of the clock genes CLOCK, BMAL1, PER1, PER2, CRY1, CRY2, REV-ERBα and DBP. In fibroblasts obtained from patients with chronic schizophrenia, we found a loss of rhythmic expression of CRY1 and PER2 compared to cells from healthy controls. We also estimated the sleep quality in these patients and found that most of them suffered from poor sleep in comparison with the healthy controls. In another patient sample, we analyzed mononuclear blood cells from patients with schizophrenia experiencing their first episode of psychosis, and found decreased expression of CLOCK, PER2 and CRY1 compared to blood cells from healthy controls. These novel findings show disturbances in the molecular clock in schizophrenia and have important implications in our understanding of the aberrant rhythms reported in this disease. PMID:27132483

  14. The hypothalamic clock and its control of glucose homeostasis

    NARCIS (Netherlands)

    A. Kalsbeek; C.X. Yi; S.E. la Fleur; E. Fliers

    2010-01-01

    The everyday life of mammals, including humans, exhibits many behavioral, physiological and endocrine oscillations. The major timekeeping mechanism for these rhythms is contained in the central nervous system (CNS). The output of the CNS clock not only controls daily rhythms in sleep/wake (or feedin

  15. Enhanced Phenotyping of Complex Traits with a Circadian Clock Model

    NARCIS (Netherlands)

    Merrow, Martha; Roenneberg, Till

    2005-01-01

    Models of biological systems are increasingly used to generate and test predictions in silico. This article explores the basic workings of a multifeedback network model of a circadian clock. In a series of in silico experiments, we investigated the influence of the number of feedbacks by adding and

  16. Clock ambiguity and the emergence of physical laws

    International Nuclear Information System (INIS)

    The process of identifying a time variable in time-reparameterization invariant theories results in great ambiguities about the actual laws of physics described by a given theory. A theory set up to describe one set of physical laws can equally well be interpreted as describing any other laws of physics by making a different choice of time variable or clock. In this article we demonstrate how this 'clock ambiguity' arises and then discuss how one might still hope to extract specific predictions about the laws of physics even when the clock ambiguity is present. We argue that a requirement of quasiseparability should play a critical role in such an analysis. As a step in this direction, we compare the Hamiltonian of a local quantum field theory with a completely random Hamiltonian. We find that any random Hamiltonian (constructed in a sufficiently large space) can yield a 'good enough' approximation to a local field theory. Based on this result we argue that theories that suffer from the clock ambiguity may in the end provide a viable fundamental framework for physics in which locality can be seen as a strongly favored (or predicted) emergent behavior. We also speculate on how other key aspects of known physics such as gauge symmetries and Poincare invariance might be predicted to emerge in this framework.

  17. A Medieval Clock Made out of Simple Materials

    Science.gov (United States)

    Danese, B.; Oss, S.

    2008-01-01

    A cheap replica of the verge-and-foliot clock has been built from simple materials. It is a didactic tool of great power for physics teaching at every stage of schooling, in particular at university level. An account is given of its construction and its working principles, together with motivated examples of a few activities. (Contains 3 tables…

  18. Phase resetting of the mammalian circadian clock by DNA damage

    NARCIS (Netherlands)

    Oklejewicz, Malgorzata; Destici, Eugin; Tamanini, Filippo; Hut, Roelof A.; Janssens, Roel; van der Horst, Gijsbertus T. J.

    2008-01-01

    To anticipate the momentum of the day, most organisms have developed an internal clock that drives circadian rhythms in metabolism, physiology, and behavior [1]. Recent studies indicate that cell-cycle progression and DNA-damage-response pathways are under circadian control [2-4]. Because circadian

  19. The Cell Cycle & Circadian Clock: a tale of two cycles

    NARCIS (Netherlands)

    E. Destici (Eugin)

    2010-01-01

    textabstractMost organisms have evolved an internal timekeeper to anticipate and coordinate internal processes with the external 24-h environment imposed upon all living creatures due to rotation of the Earth around its axis. At the cellular level, the circadian clock is generated by a genetic progr

  20. Mammalian circadian clock and metabolism - the epigenetic link.

    Science.gov (United States)

    Bellet, Marina Maria; Sassone-Corsi, Paolo

    2010-11-15

    Circadian rhythms regulate a wide variety of physiological and metabolic processes. The clock machinery comprises complex transcriptional-translational feedback loops that, through the action of specific transcription factors, modulate the expression of as many as 10% of cellular transcripts. This marked change in gene expression necessarily implicates a global regulation of chromatin remodeling. Indeed, various descriptive studies have indicated that histone modifications occur at promoters of clock-controlled genes (CCGs) in a circadian manner. The finding that CLOCK, a transcription factor crucial for circadian function, has intrinsic histone acetyl transferase (HAT) activity has paved the way to unraveling the molecular mechanisms that govern circadian chromatin remodeling. A search for the histone deacetylase (HDAC) that counterbalances CLOCK activity revealed that SIRT1, a nicotinamide adenin dinucleotide (NAD(+))-dependent HDAC, functions in a circadian manner. Importantly, SIRT1 is a regulator of aging, inflammation and metabolism. As many transcripts that oscillate in mammalian peripheral tissues encode proteins that have central roles in metabolic processes, these findings establish a functional and molecular link between energy balance, chromatin remodeling and circadian physiology. Here we review recent studies that support the existence of this link and discuss their implications for understanding mammalian physiology and pathology. PMID:21048160

  1. The Chemical and Educational Appeal of the Orange Juice Clock.

    Science.gov (United States)

    Kelter, Paul B.; And Others

    1996-01-01

    Describes the recent history, chemistry, and educational uses of the Orange Juice Clock demonstration in which a galvanic cell is made from the combination of a magnesium strip, a copper strip, and juice in a beaker. Discusses the chemistry basics, extensions for more advanced students, questions for student/teacher workshop participants, and…

  2. The AGS Ggamma Meter and Calibrating the Gauss Clock

    Energy Technology Data Exchange (ETDEWEB)

    Ahrens, Leif [Brookhaven National Laboratory (BNL), Upton, NY (United States). Collider-Accelerator Dept.

    2014-03-31

    During AGS Polarized Proton acceleration periods, one output from the AGS Ggamma Meter, namely the energy (or Ggamma) calculated from the magnetic field in the AGS main magnets and the beam radius- both measured in particular instant, is used to figure out the times in the AGS magnet acceleration cycle when the beam passes through a particular set of depolarizing resonances. The resonance set occur whenever a particle’s Ggamma (energy*(G/m) becomes nearly equal to n*Qx (i.e. any integer multiplied by the horizontal betatron tune). This deliverable is why the machinery is referred to as the ''Ggamma Meter'' rather than the AGS energy meter. The Ggamma Meter takes as inputs a set of measurements of frequency (F(t)), radius (r(t)), and gauss clock counts (GCC(t)). The other energy (GgammaBr) assumes the field when the gauss clock starts counting is known. The change in field to time t is given by the measured accumulated gauss clock counts multiplied by the gauss clock calibration (gauss/GCC). In order to deal with experimental data, this calibration factor gets an added ad hoc complication, namely a correction dependent on the rate of change the counting rate. The Ggamma meter takes GCC(t) and together with the past history for this cycle calculates B(t).

  3. Disruption of the somitic molecular clock causes abnormal vertebral segmentation.

    Science.gov (United States)

    Sparrow, Duncan B; Chapman, Gavin; Turnpenny, Peter D; Dunwoodie, Sally L

    2007-06-01

    Somites are the precursors of the vertebral column. They segment from the presomitic mesoderm (PSM) that is caudally located and newly generated from the tailbud. Somites form in synchrony on either side of the embryonic midline in a reiterative manner. A molecular clock that operates in the PSM drives this reiterative process. Genetic manipulation in mouse, chick and zebrafish has revealed that the molecular clock controls the activity of the Notch and WNT signaling pathways in the PSM. Disruption of the molecular clock impacts on somite formation causing abnormal vertebral segmentation (AVS). A number of dysmorphic syndromes manifest AVS defects. Interaction between developmental biologists and clinicians has lead to groundbreaking research in this area with the identification that spondylocostal dysostosis (SCD) is caused by mutation in Delta-like 3 (DLL3), Mesoderm posterior 2 (MESP2), and Lunatic fringe (LFNG); three genes that are components of the Notch signaling pathway. This review describes our current understanding of the somitic molecular clock and highlights how key findings in developmental biology can impact on clinical practice.

  4. Special Relativity in Week One: 2) All Clocks Run Slow

    Science.gov (United States)

    Huggins, Elisha

    2011-01-01

    In our initial article on teaching special relativity in the first week of an introductory physics course, we used the principle of relativity and Maxwell's theory of light to derive Einstein's second postulate (that the speed of light is the same to all observers). In this paper we study thought experiments involving a light pulse clock moving…

  5. Atomic secrecy

    International Nuclear Information System (INIS)

    An article, The H-Bomb Secret: How We Got It, Why We're Telling It, by Howard Morland was to be published in The Progressive magazine in February, 1979. The government, after learning of the author's and the editors' intention to publish the article and failing to persuade them to voluntarily delete about 20% of the text and all of the diagrams showing how an H-bomb works, requested a court injunction against publication. Acting under the Atomic Energy Act of 1954, US District Court Judge Robert W. Warren granted the government's request on March 26. Events dealing with the case are discussed in this publication. Section 1, Progressive Hydrogen Bomb Case, is discussed under the following: Court Order Blocking Magazine Report; Origins of the Howard Morland Article; Author's Motives, Defense of Publication; and Government Arguments Against Disclosure. Section 2, Access to Atomic Data Since 1939, contains information on need for secrecy during World War II; 1946 Atomic Energy Act and its effects; Soviet A-Bomb and the US H-Bomb; and consequences of 1954 Atomic Energy Act. Section 3, Disputed Need for Atomic Secrecy, contains papers entitled: Lack of Studies on H-Bomb Proliferation; Administration's Position on H-Bombs; and National Security Needs vs Free Press

  6. Nobel Prize in Physics 1997 "for development of methods to cool and trap atoms with laser light" : Steven Chu, Claude Cohen-Tannoudji and William D. Phillips

    CERN Multimedia

    1998-01-01

    Prof.S. Chu presents "the manipulation of atoms and bio-molecules by laser light" : a brief history of the laser cooling and trapping of atoms developed over the past 15 years will be presented. The cooling and trapping technology is already being applied in numerous areas of science and engineering. Applications to be discussed include atomic clocks, atom interferometers, as well as studies in polymer dynamics and protein motion.

  7. CULLIN-3 controls TIMELESS oscillations in the Drosophila circadian clock.

    Directory of Open Access Journals (Sweden)

    Brigitte Grima

    Full Text Available Eukaryotic circadian clocks rely on transcriptional feedback loops. In Drosophila, the PERIOD (PER and TIMELESS (TIM proteins accumulate during the night, inhibit the activity of the CLOCK (CLK/CYCLE (CYC transcriptional complex, and are degraded in the early morning. The control of PER and TIM oscillations largely depends on post-translational mechanisms. They involve both light-dependent and light-independent pathways that rely on the phosphorylation, ubiquitination, and proteasomal degradation of the clock proteins. SLMB, which is part of a CULLIN-1-based E3 ubiquitin ligase complex, is required for the circadian degradation of phosphorylated PER. We show here that CULLIN-3 (CUL-3 is required for the circadian control of PER and TIM oscillations. Expression of either Cul-3 RNAi or dominant negative forms of CUL-3 in the clock neurons alters locomotor behavior and dampens PER and TIM oscillations in light-dark cycles. In constant conditions, CUL-3 deregulation induces behavioral arrhythmicity and rapidly abolishes TIM cycling, with slower effects on PER. CUL-3 affects TIM accumulation more strongly in the absence of PER and forms protein complexes with hypo-phosphorylated TIM. In contrast, SLMB affects TIM more strongly in the presence of PER and preferentially associates with phosphorylated TIM. CUL-3 and SLMB show additive effects on TIM and PER, suggesting different roles for the two ubiquitination complexes on PER and TIM cycling. This work thus shows that CUL-3 is a new component of the Drosophila clock, which plays an important role in the control of TIM oscillations.

  8. Gravitational wave detection using atom interferometry

    Science.gov (United States)

    Hogan, Jason

    2016-05-01

    The advent of gravitational wave astronomy promises to provide a new window into the universe. Low frequency gravitational waves below 10 Hz are expected to offer rich science opportunities both in astrophysics and cosmology, complementary to signals in LIGO's band. Detector designs based on atom interferometry have a number of advantages over traditional approaches in this band, including the possibility of substantially reduced antenna baseline length in space and high isolation from seismic noise for a terrestrial detector. In particular, atom interferometry based on the clock transition in group II atoms offers tantalizing new possibilities. Such a design is expected to be highly immune to laser frequency noise because the signal arises strictly from the light propagation time between two ensembles of atoms. This would allow for a gravitational wave detector with a single linear baseline, potentially offering advantages in cost and design flexibility. In support of these proposals, recent progress in long baseline atom interferometry in a 10-meter drop tower has enabled observation of matter wave interference with atomic wavepacket separations exceeding 50 cm and interferometer durations of more than 2 seconds. This approach can provide ground-based proof-of-concept demonstrations of many of the technical requirements of both terrestrial and satellite gravitational wave detectors.

  9. Clock recovering characteristics of adaptive finite-impulse-response filters in digital coherent optical receivers.

    Science.gov (United States)

    Kikuchi, Kazuro

    2011-03-14

    We analyze the clock-recovery process based on adaptive finite-impulse-response (FIR) filtering in digital coherent optical receivers. When the clock frequency is synchronized between the transmitter and the receiver, only five taps in half-symbol-spaced FIR filters can adjust the sampling phase of analog-to-digital conversion optimally, enabling bit-error rate performance independent of the initial sampling phase. Even if the clock frequency is not synchronized between them, the clock-frequency misalignment can be adjusted within an appropriate block interval; thus, we can achieve an asynchronous clock mode of operation of digital coherent receivers with block processing of the symbol sequence. PMID:21445201

  10. Deep RNA profiling identified CLOCK and molecular clock genes as pathophysiological signatures in collagen VI myopathy.

    Science.gov (United States)

    Scotton, Chiara; Bovolenta, Matteo; Schwartz, Elena; Falzarano, Maria Sofia; Martoni, Elena; Passarelli, Chiara; Armaroli, Annarita; Osman, Hana; Rodolico, Carmelo; Messina, Sonia; Pegoraro, Elena; D'Amico, Adele; Bertini, Enrico; Gualandi, Francesca; Neri, Marcella; Selvatici, Rita; Boffi, Patrizia; Maioli, Maria Antonietta; Lochmüller, Hanns; Straub, Volker; Bushby, Katherine; Castrignanò, Tiziana; Pesole, Graziano; Sabatelli, Patrizia; Merlini, Luciano; Braghetta, Paola; Bonaldo, Paolo; Bernardi, Paolo; Foley, Reghan; Cirak, Sebahattin; Zaharieva, Irina; Muntoni, Francesco; Capitanio, Daniele; Gelfi, Cecilia; Kotelnikova, Ekaterina; Yuryev, Anton; Lebowitz, Michael; Zhang, Xiping; Hodge, Brian A; Esser, Karyn A; Ferlini, Alessandra

    2016-04-15

    Collagen VI myopathies are genetic disorders caused by mutations in collagen 6 A1, A2 and A3 genes, ranging from the severe Ullrich congenital muscular dystrophy to the milder Bethlem myopathy, which is recapitulated by collagen-VI-null (Col6a1(-/-)) mice. Abnormalities in mitochondria and autophagic pathway have been proposed as pathogenic causes of collagen VI myopathies, but the link between collagen VI defects and these metabolic circuits remains unknown. To unravel the expression profiling perturbation in muscles with collagen VI myopathies, we performed a deep RNA profiling in bothCol6a1(-/-)mice and patients with collagen VI pathology. The interactome map identified common pathways suggesting a previously undetected connection between circadian genes and collagen VI pathology. Intriguingly,Bmal1(-/-)(also known asArntl) mice, a well-characterized model displaying arrhythmic circadian rhythms, showed profound deregulation of the collagen VI pathway and of autophagy-related genes. The involvement of circadian rhythms in collagen VI myopathies is new and links autophagy and mitochondrial abnormalities. It also opens new avenues for therapies of hereditary myopathies to modulate the molecular clock or potential gene-environment interactions that might modify muscle damage pathogenesis. PMID:26945058

  11. Turning Back the Clock: Inferring the History of the Eight O'clock Arc

    CERN Document Server

    Finkelstein, Steven L; Rudnick, Gregory; Egami, Eiichi; Floc'h, Emeric Le; Rieke, Marcia J; Rigby, Jane; Willmer, Christopher N A

    2009-01-01

    We present the results from an optical and near-infrared spectroscopic study of the ultraviolet-luminous z = 2.73 galaxy, the 8 o'clock arc. Due to gravitational lensing, this galaxy is magnified by a factor of > 10, allowing in-depth measurements which are usually unfeasible at such redshifts. In the optical spectra, we measured the systemic redshift of the galaxy, z = 2.7322 +/- 0.0012, using stellar photospheric lines. This differs from the redshift of absorption lines in the interstellar medium, z = 2.7302 +/- 0.0006, implying gas outflows on the order of 160 km/s. With H and K-band near-infrared spectra, we have measured nebular emission lines of Halpha, Hbeta, Hgamma, [N II] and [O III], which have a redshift z = 2.7333 +/- 0.0001, consistent with the derived systemic redshift. From the Balmer decrement, we measured the dust extinction to be A_5500 = 0.53 +/- 0.16 mag. Correcting Halpha for dust extinction and the assumed lensing factor, we measure a star-formation rate of ~ 90 Msol/yr, which is higher ...

  12. Deep RNA profiling identified CLOCK and molecular clock genes as pathophysiological signatures in collagen VI myopathy.

    Science.gov (United States)

    Scotton, Chiara; Bovolenta, Matteo; Schwartz, Elena; Falzarano, Maria Sofia; Martoni, Elena; Passarelli, Chiara; Armaroli, Annarita; Osman, Hana; Rodolico, Carmelo; Messina, Sonia; Pegoraro, Elena; D'Amico, Adele; Bertini, Enrico; Gualandi, Francesca; Neri, Marcella; Selvatici, Rita; Boffi, Patrizia; Maioli, Maria Antonietta; Lochmüller, Hanns; Straub, Volker; Bushby, Katherine; Castrignanò, Tiziana; Pesole, Graziano; Sabatelli, Patrizia; Merlini, Luciano; Braghetta, Paola; Bonaldo, Paolo; Bernardi, Paolo; Foley, Reghan; Cirak, Sebahattin; Zaharieva, Irina; Muntoni, Francesco; Capitanio, Daniele; Gelfi, Cecilia; Kotelnikova, Ekaterina; Yuryev, Anton; Lebowitz, Michael; Zhang, Xiping; Hodge, Brian A; Esser, Karyn A; Ferlini, Alessandra

    2016-04-15

    Collagen VI myopathies are genetic disorders caused by mutations in collagen 6 A1, A2 and A3 genes, ranging from the severe Ullrich congenital muscular dystrophy to the milder Bethlem myopathy, which is recapitulated by collagen-VI-null (Col6a1(-/-)) mice. Abnormalities in mitochondria and autophagic pathway have been proposed as pathogenic causes of collagen VI myopathies, but the link between collagen VI defects and these metabolic circuits remains unknown. To unravel the expression profiling perturbation in muscles with collagen VI myopathies, we performed a deep RNA profiling in both Col6a1(-/-)mice and patients with collagen VI pathology. The interactome map identified common pathways suggesting a previously undetected connection between circadian genes and collagen VI pathology. Intriguingly, Bmal1(-/-)(also known as Arntl) mice, a well-characterized model displaying arrhythmic circadian rhythms, showed profound deregulation of the collagen VI pathway and of autophagy-related genes. The involvement of circadian rhythms in collagen VI myopathies is new and links autophagy and mitochondrial abnormalities. It also opens new avenues for therapies of hereditary myopathies to modulate the molecular clock or potential gene-environment interactions that might modify muscle damage pathogenesis.

  13. Atomic theories

    CERN Document Server

    Loring, FH

    2014-01-01

    Summarising the most novel facts and theories which were coming into prominence at the time, particularly those which had not yet been incorporated into standard textbooks, this important work was first published in 1921. The subjects treated cover a wide range of research that was being conducted into the atom, and include Quantum Theory, the Bohr Theory, the Sommerfield extension of Bohr's work, the Octet Theory and Isotopes, as well as Ionisation Potentials and Solar Phenomena. Because much of the material of Atomic Theories lies on the boundary between experimentally verified fact and spec

  14. High-order inertial phase shifts for time-domain atom interferometers

    CERN Document Server

    Bongs, K; Kasevich, M A; Bongs, Kai; Launay, Romain; Kasevich, Mark A.

    2002-01-01

    High-order inertial phase shifts are calculated for time-domain atom interferometers. We obtain closed-form analytic expressions for these shifts in accelerometer, gyroscope, optical clock and photon recoil measurement configurations. Our analysis includes Coriolis, centrifugal, gravitational, and gravity gradient-induced forces. We identify new shifts which arise at levels relevant to current and planned experiments.

  15. FOREWORD: Fifty years of atomic time-keeping: 1955 to 2005

    Science.gov (United States)

    Quinn, Terry

    2005-06-01

    The year 2005 is the centenary of Einstein's four famous papers that were published in 1905. This anniversary is being widely celebrated all over the world and, indeed, 2005 has been dubbed World Year of Physics. The year 2005, however, also marks the fiftieth anniversary of the first operation of Essen and Parry's caesium beam atomic frequency standard at the NPL in May 1955. While Einstein's papers signalled a revolution in physics and in our understanding of the natural world, the first atomic clock signalled a revolution in time-keeping that has become, among other things, one of the most powerful tools in pushing back the frontiers of Einstein's theories of special and general relativity. The atomic clock has also had consequences for navigation comparable to those brought about by Harrison's mechanical clocks almost exactly two hundred years before. Harrison's H3 was completed in 1757 and H4 in 1759. The atomic clock, and the creation of an atomic time scale that quickly followed, led ten years later to the adoption of an atomic definition for the SI second in Resolution 1 of the 13th General Conference on Weights and Measures, 1967/68. This marked the end of time-keeping based on the movements of the heavenly bodies that had beaten the rhythm of the days and the seasons since the dawn of human civilization. Fifty years on is a good occasion to look back, to look forward and at the same time to examine where we are today, in terms of measuring time. While we still arrange for our atomic clocks to show noon when the sun is overhead on the Greenwich meridian, everything else has changed in the fifty years since 1955. In this special issue of Metrologia the reader will find articles on the development of the atomic clock, its theory and practice, how the first atomic time scale was devised and formally introduced and how we maintain atomic time today, as well as articles looking forward to even more accurate clocks and time scales. Included also are articles on

  16. NPAS2 Compensates for Loss of CLOCK in Peripheral Circadian Oscillators.

    Directory of Open Access Journals (Sweden)

    Dominic Landgraf

    2016-02-01

    Full Text Available Heterodimers of CLOCK and BMAL1 are the major transcriptional activators of the mammalian circadian clock. Because the paralog NPAS2 can substitute for CLOCK in the suprachiasmatic nucleus (SCN, the master circadian pacemaker, CLOCK-deficient mice maintain circadian rhythms in behavior and in tissues in vivo. However, when isolated from the SCN, CLOCK-deficient peripheral tissues are reportedly arrhythmic, suggesting a fundamental difference in circadian clock function between SCN and peripheral tissues. Surprisingly, however, using luminometry and single-cell bioluminescence imaging of PER2 expression, we now find that CLOCK-deficient dispersed SCN neurons and peripheral cells exhibit similarly stable, autonomous circadian rhythms in vitro. In CLOCK-deficient fibroblasts, knockdown of Npas2 leads to arrhythmicity, suggesting that NPAS2 can compensate for loss of CLOCK in peripheral cells as well as in SCN. Our data overturn the notion of an SCN-specific role for NPAS2 in the molecular circadian clock, and instead indicate that, at the cellular level, the core loops of SCN neuron and peripheral cell circadian clocks are fundamentally similar.

  17. Osmotic stress at the barley root affects expression of circadian clock genes in the shoot.

    Science.gov (United States)

    Habte, Ermias; Müller, Lukas M; Shtaya, Munqez; Davis, Seth J; von Korff, Maria

    2014-06-01

    The circadian clock is an important timing system that controls physiological responses to abiotic stresses in plants. However, there is little information on the effects of the clock on stress adaptation in important crops, like barley. In addition, we do not know how osmotic stress perceived at the roots affect the shoot circadian clock. Barley genotypes, carrying natural variation at the photoperiod response and clock genes Ppd-H1 and HvELF3, were grown under control and osmotic stress conditions to record changes in the diurnal expression of clock and stress-response genes and in physiological traits. Variation at HvELF3 affected the expression phase and shape of clock and stress-response genes, while variation at Ppd-H1 only affected the expression levels of stress genes. Osmotic stress up-regulated expression of clock and stress-response genes and advanced their expression peaks. Clock genes controlled the expression of stress-response genes, but had minor effects on gas exchange and leaf transpiration. This study demonstrated that osmotic stress at the barley root altered clock gene expression in the shoot and acted as a spatial input signal into the clock. Unlike in Arabidopsis, barley primary assimilation was less controlled by the clock and more responsive to environmental perturbations, such as osmotic stress. PMID:24895755

  18. Design and Analysis of Sequential Elements for Low Power Clocking System with Low Power Techniques

    Directory of Open Access Journals (Sweden)

    S.Sasidhar Reddy

    2014-09-01

    Full Text Available This paper proposed the design of sequential elements for low power clocking system with low low power techniques for saving the power. Power consumption is a major bottleneck of system performance and is listed as one of the top three challenges in International Technology Roadmap for Semiconductor 2008. In practice, a large portion of the on chip power is consumed by the clock system which is made of the clock distribution network and flop-flops. In this paper, various design techniques for a low power clocking system are surveyed. Among them is an effective way to reduce capacity of the clock load by minimizing number of clocked transistors. To approach this, proposed a novel clocked pair shared flip-flop which reduces the number of local clocked transistors by approximately 40%. A 24% reduction of clock driving power is achieved. In addition, low swing and double edge clocking, can be easily incorporated into the new flip-flop to build clocking systems. As the feature size becomes smaller, shorter channel lengths result in increased sub-threshold leakage current through a transistor when it is off. Dual sleep and sleepy stack methods are proposed to avoid static power consumption; the flip flops are simulated using HSPICE.

  19. Interactions between the circadian clock and metabolism: there are good times and bad times

    Institute of Scientific and Technical Information of China (English)

    Mi Shi; Xiangzhong Zheng

    2013-01-01

    An endogenous circadian (~24 h) clock regulates rhythmic processes of physiology,metabolism and behavior in most living organisms.While able to free-run under constant conditions,the circadian clock is coupled to day:night cycles to increase its amplitude and align the phase of circadian rhythms to the right time of the day.Disruptions of the circadian clock are correlated with brain dysfunctions,cardiovascular diseases and metabolic disorders.In this review,we focus on the interactions between the circadian clock and metabolism.We discuss recent findings on circadian clock regulation of feeding behavior and rhythmic expression of metabolic genes,and present evidence of metabolic input to the circadian clock.We emphasize how misalignment of circadian clocks within the body and with environmental cycles or daily schedules leads to the increasing prevalence of metabolic syndromes in modern society.

  20. Divergent roles of clock genes in retinal and suprachiasmatic nucleus circadian oscillators.

    Directory of Open Access Journals (Sweden)

    Guo-Xiang Ruan

    Full Text Available The retina is both a sensory organ and a self-sustained circadian clock. Gene targeting studies have revealed that mammalian circadian clocks generate molecular circadian rhythms through coupled transcription/translation feedback loops which involve 6 core clock genes, namely Period (Per 1 and 2, Cryptochrome (Cry 1 and 2, Clock, and Bmal1 and that the roles of individual clock genes in rhythms generation are tissue-specific. However, the mechanisms of molecular circadian rhythms in the mammalian retina are incompletely understood and the extent to which retinal neural clocks share mechanisms with the suprachiasmatic nucleus (SCN, the central neural clock, is unclear. In the present study, we examined the rhythmic amplitude and period of real-time bioluminescence rhythms in explants of retina from Per1-, Per2-, Per3-, Cry1-, Cry2-, and Clock-deficient mice that carried transgenic PERIOD2::LUCIFERASE (PER2::LUC or Period1::luciferase (Per1::luc circadian reporters. Per1-, Cry1- and Clock-deficient retinal and SCN explants showed weakened or disrupted rhythms, with stronger effects in retina compared to SCN. Per2, Per3, and Cry2 were individually dispensable for sustained rhythms in both tissues. Retinal and SCN explants from double knockouts of Cry1 and Cry2 were arrhythmic. Gene effects on period were divergent with reduction in the number of Per1 alleles shortening circadian period in retina, but lengthening it in SCN, and knockout of Per3 substantially shortening retinal clock period, but leaving SCN unaffected. Thus, the retinal neural clock has a unique pattern of clock gene dependence at the tissue level that it is similar in pattern, but more severe in degree, than the SCN neural clock, with divergent clock gene regulation of rhythmic period.