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Sample records for atomic bomb survivor

  1. Glaucoma in atomic bomb survivors.

    Science.gov (United States)

    Kiuchi, Yoshiaki; Yokoyama, Tomoko; Takamatsu, Michiya; Tsuiki, Eiko; Uematsu, Masafumi; Kinoshita, Hirofumi; Kumagami, Takeshi; Kitaoka, Takashi; Minamoto, Atsushi; Neriishi, Kazuo; Nakashima, Eiji; Khattree, Ravindra; Hida, Ayumi; Fujiwara, Saeko; Akahoshi, Masazumi

    2013-10-01

    Radiation has been associated with increases in noncancerous diseases. An effect of low-dose radiation on the prevalence of clinically detected glaucoma has not been previously reported. We therefore investigated the prevalence of glaucoma in A-bomb survivors and its possible association with radiation dose. A total of 1,589 people who participated in the clinical examination program for A-bomb survivors at the Radiation Effects Research Foundation (RERF) between October 2006 and September 2008 and who had reconstructed radiation doses, were recruited into this cross-sectional screening study. The prevalence of glaucoma and its dose-response relationship to A-bomb radiation were measured. Each subject underwent an initial screening consisting of an interview and ophthalmological examination. Questionable cases with any indication of ocular disease, including glaucoma, were referred to local hospitals for more comprehensive evaluation. A diagnosis of glaucoma was made based on specific optic disc appearance, perimetric results and other ocular findings. Of 1,589 eligible people, we detected 284 (17.9%) cases of glaucoma overall, including 36 (2.3%) cases of primary open-angle glaucoma with intraocular pressure levels greater than 21 mmHg, 226 (14.2%) cases of normal-tension glaucoma and 25 (1.6%) cases of primary angle-closure glaucoma. Seven glaucoma risk factors were examined as potential confounders but only two needed to be included in the final model. Binary regression using a generalized estimating equation method, with adjustment for gender, age, city, cataract surgery or diabetes mellitus, revealed an odds ratio at 1 Gy of 1.31 (95% confidence interval 1.11-1.53, P = 0.001) in the case of normal-tension glaucoma, but no association for other types of glaucoma. The prevalence of normal-tension glaucoma may increase with A-bomb radiation dose, but uncertainties associated with nonparticipation (59% participation) suggest caution in the interpretation of these

  2. Colorectal cancer among atomic bomb survivors

    International Nuclear Information System (INIS)

    Studies on autopsied and surgical cases of colorectal cancer in Hiroshima and Nagasaki atomic bomb (A-bomb) survivors have not shown a relationship to radiation. In a recent epidemiologic study made on a fixed population at the Radiation Effects Research Foundation (RERF), the risk of colon cancer was found to increase significantly with increasing radiation dose in both Hiroshima and Nagasaki, and also in both males and females. The dose effect for the cities and sexes combined was especially pronounced for cancer of the sigmoid colon. The effect of radiation was found to vary by age at the time of the bomb (ATB) and the effect was remarkable among those under age 20 ATB. The risk of rectal cancer was not found to increase significantly with radiation and the distribution of histological types for cancer of either the colon or rectum was unrelated to radiation dose. The effect of A-bomb exposure on the postoperative survival rate for colorectal cancer patients was studied. No difference by radiation dose could be demonstrated. In Japan, the incidence of colorectal cancer, and of colon cancer in particular, has been increasing. Therefore, close attention should be paid to changes occuring in A-bomb survivors

  3. Health risks of atomic bomb survivors

    International Nuclear Information System (INIS)

    At the Atomic Bomb Casualty Commission and its successor organization, the Radiation Effects Research Foundation, mortality and morbidity surveys have been continually carried out on about 1,800 persons exposed in utero to the atomic bombings of Hiroshima and Nagasaki. Although the effect of radiation exposure was marked enough to permit observation of a dose-response relationship in the 30 known cases of severe mental retardation among the in utero-exposed, the association between in utero exposure and cancer risk is still uncertain. Based on data for all cancers from 1950 through 1984 for the in utero-exposed, the excess risk per 10,000 person-year-Gy was 6.57 and the relative risk at 1 Gy was 3.77. For the recent years 1985-89, there was no evident excess of cancer risk. During the remaining lifetime, it seems unlikely that any great excess of leukemia will appear. As for the risk of solid tumors, further follow up is in progress. The 1950-89 findings for cancer risk among the in utero-exposed will be compared with cancer risk among A-bomb survivors who were less than 10 years old at the time of the bombings. (author)

  4. Risk of cancer among atomic bomb survivors.

    Science.gov (United States)

    Shimizu, Y; Kato, H; Schull, W J

    1991-12-01

    This report describes the risk of cancer and in particular cancers other than leukemia among the survivors of the atomic bombing of Hiroshima and Nagasaki. Attention focuses primarily on the risk of death from cancer among individuals in the Life Span Study sample of the Radiation Effect Research Foundation in the period 1950-1985 based on the recently revised dosimetry, termed the DS86 doses. Mortality from malignant tumors is increased among A-bomb survivors as a late effect of A-bomb radiation. Besides the well-known increase of leukemia, there also has been demonstrated increase of cancer of the lung, breast, esophagus, stomach, colon, ovary, urinary bladder, thyroid, and of multiple myeloma, but no increase has yet been observed in mortality from cancer of the rectum, gallbladder, pancreas, prostate and uterus, and of malignant lymphoma. The pattern of appearance over time of radiation-induced cancer other than leukemia differs from that of leukemia. In general, radiation-induced solid cancer begins to appear after attaining the age at which the cancer is normally prone to develop (so-called cancer age), and continues to increase proportionately with the increase in mortality of the control group as it ages. Sensitivity to radiation, in terms of cancer induction, is higher for persons who were young at the time of the bomb (ATB) in general than for those who were older ATB. Furthermore, susceptibility to radiation-induced cancer tends to be higher in pre- than in post-natally exposed survivors (at least those exposed as adults). Other radiation effect modifiers and the shape of the dose response curve will also be discussed. PMID:1823367

  5. Mortality of atomic bomb survivors in Nagasaki

    International Nuclear Information System (INIS)

    We analyzed the risk in 2,743 atomic bomb survivors by using a new dosimetry system. From the database, we selected 2,743 exposed persons and a total of three times 2,743 age-matched controls who were living far from the center of the A-bomb radiation in Nagasaki at the time of the explosion and who were still alive in 1971. The mortalities from all causes for male subjects exposed were slightly lower than, or almost equal to, those of unexposed persons. Death from cancer, however, increased in both sexes after all levels of irradiation except in males exposed to 0.01-0.49 Gy. In males, the risk was showed significant reduction in death from all diseases other than cancer classified according to 0.31-0.40 Gy. (author)

  6. Mortality of atomic bomb survivors in Nagasaki

    Energy Technology Data Exchange (ETDEWEB)

    Mine, Mariko; Honda, Sumihisa; Kondo, Hisayoshi; Yokota, Kenichi; Tomonaga, Masao; Okumura, Yutaka [Atomic Bomb Disease Institute, Nagasaki Univ. School of Medicine, Nagasaki (Japan)

    1999-09-01

    We analyzed the risk in 2,743 atomic bomb survivors by using a new dosimetry system. From the database, we selected 2,743 exposed persons and a total of three times 2,743 age-matched controls who were living far from the center of the A-bomb radiation in Nagasaki at the time of the explosion and who were still alive in 1971. The mortalities from all causes for male subjects exposed were slightly lower than, or almost equal to, those of unexposed persons. Death from cancer, however, increased in both sexes after all levels of irradiation except in males exposed to 0.01-0.49 Gy. In males, the risk was showed significant reduction in death from all diseases other than cancer classified according to 0.31-0.40 Gy. (author)

  7. Breast cancer among atomic bomb survivors

    International Nuclear Information System (INIS)

    Three hundred and sixty cases of breast cancer were collected from among the 63,000 female members of the RERF extended Life Span Study sample which includes atomic bomb exposed women and controls of Hiroshima and Nagasaki. The relationship of these breast cancer cases to A-bomb radiation was sought, and in studying 5-year survival, the following conclusions were obtained concerning its relationship to histopathological findings: 1) The prognosis of the 50+ rad high dose group is the best, followed by the nonexposed group and the low dose group; 2) The apparently better survival may be due, at least in part, to the fact that this group is heavily weighted in favor of those who were younger at the time of the bomb; 3) There is no specificity of the histologic type of breast cancer in the survivors by dose; 4) Nor, is any significant difference observed in the distribution of tumor size and histological grade; 5) Cellular reaction is significantly marked at the stroma of carcinoma tissue in the high dose group; 6) Immune reaction is considered to be strong at the affected site of breast cancer in the high dose group and this can be regarded as a finding suggestive of good prognosis; 7) Further extended studies are therefore warranted. (author)

  8. Aging studies in atomic bomb survivors

    International Nuclear Information System (INIS)

    Although the studies of the effect of ionizing radiation on atomic bomb survivors have not produced any evidence of radiation-induced aging, there have been studies on experimental animals and man which suggest accelerated aging after exposure to ionizing radiation. To determine if certain physiologic functions could be related to exposure to ionizing radiation, a battery of age-related tests was given at the time of the physical examinations at ABCC. Some 11,351 persons were given these non-invasive age-related tests. The results were essentially negative. Until a satisfactory operational definition of biologic or physiologic age is developed, the administration of functional tests as a measure of aging does not seem justified. (author)

  9. Mortality of Atomic Bomb Survivors in Nagasaki 1

    OpenAIRE

    Mine, Mariko; Okumura, Yutaka; Kishikawa, Masao

    1991-01-01

    In 1945, an atomic bomb was exploded on Nagasaki. The Scientific Data Center for the Atomic Bomb Disaster was founded in Nagasaki University to analyse radiation effects on atomic bomb survivors. There were about 110,000 victims registered living in Nagasaki as of 1968. Since then, data of 2,000,000 items of health examination has been stored in the computer in the Scientific Data Center. The analysed results of the mortality, the survival and the risk estimation were presented.

  10. Thyroid disorders in atomic-bomb survivors

    International Nuclear Information System (INIS)

    It is known from several studies, including those from RERF that radiation exposure can cause thyroid tumors (Socolow, N Engl J Med. 1963;268:406, Parker, Ann Intern Med. 1974;80:600). Effects of radiation on autoimmune thyroid disease are not well understood. We have conducted thyroid disease screening on a population of 2856 individuals from the Adult Health Study (AHS) cohort of atomic-bomb survivors for the period of 1984-1987. This study, which for logistical reasons involved survivors only from Nagasaki, revealed a statistically significant relationship between radiation dose and prevalence of solid nodules, including cancer, and that of autoimmune hypothyroidism (Nagataki, JAMA. 1994;272:364). Because the previous thyroid study was conducted only in Nagasaki, the new comprehensive thyroid disease screening study has been ongoing in Hiroshima and Nagasaki AHS participants since March 2000. For about 4,000 participants in Hiroshima and Nagasaki AHS cohort, thyroid ultrasonography, aspiration biopsy of nodules, thyroid function test, thyroid autoantibody (thyroid peroxidase antibody and thyroglobulin antibody) test by highly sensitive assay using enzyme linked immunosorbent assay were performed for the diagnosis of thyroid diseases. Analysis of data from the 1874 people examined through July 2001 (915 people from Hiroshima, 959 people from Nagasaki) provides evidence that thyroid cancer increases with radiation dose. The prevalence of positive result for thyroid autoantibody test is increased in the people exposed to relative low dose of radiation (0.01-0.99 Sv). Examination and measurements was completed in February 2003 for all patients. The analysis of these data is providing new and more complete insights into relationships between thyroid diseases and low doses of radiation

  11. Breast cancer in atomic bomb survivors

    International Nuclear Information System (INIS)

    Thirty eight years after the atomic bombings, studies of the Radiation Effects Research Foundation (RERF) on the extended Life Span Study (LSS) sample have continued to provide important information on radiation carcinogenesis. The third breast cancer survey among this sample revealed 564 cases during the period 1950-80, of which 412 were reviewed microscopically. The following statements reflect the conclusions from the current investigation; 1) the relationship between radiation dose and breast cancer incidence was consistent with linearity and did not differ markedly between the Hiroshima and Nagasaki survivors, 2) a dose-related breast cancer risk was observed among women who were in their first decade of life at the time of exposure, 3) the relative risk of radiationinduced breast cancer decreased with increasing age at exposure, 4) the pattern over time of age-specific breast cancer incidence is similar for exposed and control women (that is, exposed women have more breast cancer than control women but the excess risk closely follows normal risk as expressed by age-specific population rates), and 5) radiation-induced breast cancer appears to be morphologically similar to other breast cancer

  12. Atomic bomb survivor data: utilization and analysis

    International Nuclear Information System (INIS)

    There were several motivations for organizing the SIMS Conference reported in this monograph. Risk assessment and its methods have been subjects of several SIMS Conferences in the recent past, and focusing these newer, more powerful methods on the largest human experience of exposure to ionizing radiation seemed an appropriate sequel. There was also the conviction that the data resources of the Radiation Effects Research Foundation (RERF), generated through the mortality and medical follow-up of large samples of the survivors of the atomic bombs dropped on Hiroshima and Nagasaki, were being under utilized, and that a conference and its proceedings would create interest in exploiting this resource. The time seemed ripe for gathering a small group of current RERF scientists, veteran US statisticians and epidemiologists, and others with more recent entry into the field of radiation biology to consider long range plans for maximizing the output of information not only on the long term effects of ionizing radiation on man but on new knowledge of the determinants of health and disease that can be learned by study of the records of this cohort. This seemed particularly appropriate at this time while intensive joint Japanese-US efforts are underway to provide a new, more accurate dosimetry for use in these studies. Finally, there was a hope that an ad hoc forum of this type would provide not only a summary of current statistical and epidemiologic activities at RERF, but a useful critique of their scope and quality

  13. Multiple myeloma among atomic bomb survivors

    International Nuclear Information System (INIS)

    The relationship between multiple myeloma in Hiroshima and Nagasaki and the estimated exposure dose is discussed. From October 1950 to December 1976 multiple myeloma was observed in 22 of 72,802 a-bomb survivors (54,116 in Hiroshima; 18,686 in Nagasaki) who were examined periodically in a life span survey by the Radiation Effects Research Foundation. The incidence per 1,000 was roughly 0.97 in a group exposed to over 100 rad, 0.30 in a group exposed to 1 to 99 rad, and 0.21 in a group exposed to less than 1 rad. There was a statistical difference (p<0.05) in relative risk which standardized city, sex, and age according to the controls exposed to less than 1 rad. An increase in risk in a group exposed to a large dose was marked in survivors aged 20 to 59 at the time of exposure. Multiple myeloma was not observed in those under 20 or over 60 years. An increase in risk in the group exposed to a large dose became marked 15 years after exposure. It is believed that the age factor, in addition to radiation, specifically influenced the occurrence of disease. (Tsunoda, M.)

  14. Mortality statistics among atomic bomb survivors in Hiroshima Prefecture

    International Nuclear Information System (INIS)

    In a comparative analysis of mortality among atomic bomb survivors versus the non-exposed, both resident in Hiroshima Prefecture, it was found that in addition to leukaemia, malignant lymphoma, multiple myeloma, and cancers of the thyroid gland, breast, lung, esophagus, stomach, urinary organs and salivary gland which have been reported from the past to be elevated in risk among atomic bomb survivors, cancers of the colon, larynx, accessory sinuses, uterus, ovary and testis, diseases of the blood, cirrhosis of liver, hypertensive disease and diabetes mellitus were elevated in risk, but the risk of cerebrovascular disease, heart disease, peptic ulcer, gastroenteritis, senility, and accidents was lower than the non-exposed. The relationship of atomic bomb exposure to the relative risk of cancers of the lung, breast, uterus, and testis could be readily explained, but the relationship between atomic bomb exposure and the relative risk of cancers of many other sites, diseases of the blood, and other causes of death was inconsistent. One of the reasons why the risk of senility was low and the risk of diseases of the blood, malignant neoplasms, diabetes mellitus, and hypertensive disease was high is considered to be the higher diagnostic accuracy in atomic bomb survivors. (author)

  15. Long-term follow-up of atomic bomb survivors.

    Science.gov (United States)

    Sakata, Ritsu; Grant, Eric J; Ozasa, Kotaro

    2012-06-01

    The Life Span Study (LSS) is a follow-up study of atomic bomb (A-bomb) survivors to investigate the radiation effects on human health and has collected data for over 60 years. The LSS cohort consists of 93,741 A-bomb survivors and another 26,580 age and sex-matched subjects who were not in either city at the time of the bombing. Radiation doses have been computed based on individual location and shielding status at the time of the bombings. Age at death and cause of death are gathered through the Japanese national family registry system and cancer incidence data have been collected through the Hiroshima and Nagasaki cancer registries. Noncancer disease incidence and health information are collected through biannual medical examinations among a subset of the LSS. Radiation significantly increases the risks of death (22% at 1 Gy), cancer incidence (47% at 1 Gy), death due to leukemia (310% at 1 Gy), as well as the incidence of several noncancer diseases (e.g. thyroid nodules, chronic liver disease and cirrhosis, uterine myoma, and hypertension). Significant effects on maturity (e.g. growth reduction and early menopause) were also observed. Long-term follow-up studies of the A-bomb survivors have provided reliable information on health risks for the survivors and form the basis for radiation protection standards for workers and the public. PMID:22440534

  16. Lymphocyte cytotoxicity of colchicine in Hiroshima atomic bomb survivors

    International Nuclear Information System (INIS)

    The cytotoxicity of colchicine for the peripheral blood lymphocytes of 151 Hiroshima atomic bomb survivors and their controls was determined. No radiation effect was found, but modest age-related changes for the initial number of vialble cells and for the cytotoxicity of colchicine were observed. (author)

  17. Effects of radiation on the incidence of prostate cancer among Nagasaki atomic bomb survivors

    OpenAIRE

    Kondo, Hisayoshi; Soda, Midori; Mine, Mariko; Yokota, Kenichi

    2013-01-01

    Atomic bomb survivors have been reported to have an increased risk of some cancers, especially leukemia. However, the risk of prostate cancer in atomic bomb survivors is not known to have been examined previously. This study examined the association between atomic bomb radiation and the incidence of prostate cancer among male Nagasaki atomic bomb survivors. The subjects were classified by distance from the hypocenter into a proximal group (

  18. High incidence of meningioma among Hiroshima atomic bomb survivors

    Energy Technology Data Exchange (ETDEWEB)

    Shintani, Takahiro; Hayakawa, Norihiko; Hoshi, Masaharu [Hiroshima Univ. (Japan). Research Inst. for Radiation Biology and Medicine] [and others

    1999-03-01

    Since the atomic bomb explosions in Hiroshima and Nagasaki, high incidences of leukemia, thyroid cancer and other tumors have been reported as atomic bomb-induced tumors. We investigated the incidence of meningioma among Hiroshima atomic bomb survivors. Sixty-eight patients surgically treated for meningioma who had been within 2.0 km of the hypocenter of the explosion were identified. Six hundred and seven non-exposed patients with meningioma were also studied. Treatment dates were from 1975 to 1992. The incidences of meningioma among 68 subjects within 2.0 km and 607 non-exposed patients were 8.7 and 3.0 cases per 10{sup 5} persons per year, respectively. The incidences of meningioma among the survivors of Hiroshima in 5-year intervals since 1975 were 5.3, 7.4, 10.1, and 14.9, respectively. The incidences of meningioma classified by distances from the hypocenter of 1.5-2.0 km, 1.0-1.5 km and less than 1.0 km were 6.3, 7.6 and 20.0, respectively. The incidences of meningioma classified by doses to the brain of 0-0.099 Sv, 0.1-0.99 Sv and more than 1.0 Sv were 7.7, 9.2 and 18.2, respectively. The incidence of meningioma among Hiroshima atomic bomb survivors has increased since 1975. There was a significant correlation between the incidence and the dose of radiation to the brain. The present findings strongly suggest that meningioma is one of the tumors induced by atomic bombing in Hiroshima. (author)

  19. High incidence of meningioma among Hiroshima atomic bomb survivors.

    Science.gov (United States)

    Shintani, T; Hayakawa, N; Hoshi, M; Sumida, M; Kurisu, K; Oki, S; Kodama, Y; Kajikawa, H; Inai, K; Kamada, N

    1999-03-01

    Since the atomic bomb explosions in Hiroshima and Nagasaki, high incidences of leukemia, thyroid cancer and other tumors have been reported as atomic bomb-induced tumors. We investigated the incidence of meningioma among Hiroshima atomic bomb survivors. Sixty-eight patients surgically treated for meningioma who had been within 2.0 km of the hypocenter of the explosion were identified. Six hundred and seven non-exposed patients with meningioma were also studied. Treatment dates were from 1975 to 1992. The incidences of meningioma among 68 subjects within 2.0 km and 607 non-exposed patients were 8.7 and 3.0 cases per 10(5) persons per year, respectively. The incidences of meningioma among the survivors of Hiroshima in 5-year intervals since 1975 were 5.3, 7.4, 10.1, and 14.9, respectively. The incidences of meningioma classified by distances from the hypocenter of 1.5-2.0 km, 1.0-1.5 km and less than 1.0 km were 6.3, 7.6 and 20.0, respectively. The incidences of meningioma classified by doses to the brain of 0-0.099 Sv, 0.1-0.99 Sv and more than 1.0 Sv were 7.7, 9.2 and 18.2, respectively. The incidence of meningioma among Hiroshima atomic bomb survivors has increased since 1975. There was a significant correlation between the incidence and the dose of radiation to the brain. The present findings strongly suggest that meningioma is one of the tumors induced by atomic bombing in Hiroshima. PMID:10408177

  20. Foreign bodies radiographically-demonstrated in atomic bomb survivors

    Energy Technology Data Exchange (ETDEWEB)

    Tamura, S.; Onitsuka, H.; Lee, K.; Shimizu, Y.; Russell, W.J.

    1978-08-25

    The prevalence of roentgenologically-detected foreign bodies among atomic bomb (A-bomb) survivors was studied as an indicator of the A-bomb blast effects. Acupuncture was studied as an indicator of A-bomb-related abnormalities for which it was administered. All Adult Health Study subjects' roentgenograms demonstrating foreign bodies were reviewed. The frequency of glass and metal, and acupuncture needles were analyzed by distance from hypocenters, sex, age, body sites involved; and the subjects' shielding at the times of the A-bombs. The presence of glass fragments correlated closely with distance from hypocenter, heavy shielding from the A-bombs, and with adulthood, and they were more frequent in the chest than hand and wrist. Metal foreign bodies were more frequent in the hand and wrist than in the chest, and not associated with distance from hypocenter or heavy shielding. The prevalence of acupuncture needles increased with age, but did not correlate with A-bomb dose.

  1. Cancer Mortality in Nagasaki Atomic Bomb Survivors with Epilation

    OpenAIRE

    Yokota, Ken-Ichi; Mine, Mariko; Honda, Sumihisa; Tomonaga, Masao

    2005-01-01

    To elucidate the association between epilation and cancer mortality in Nagasaki atomic bomb survivors, cancer mortality was determined for a total of 9,356 survivors (3,591 males and 5,765 females) from 1 January 1970 to 31 December 1997. The subjects included individuals other than those in the Life Span Study (LSS) cohort of ABCC-RERF. Information on acute injury was obtained from a survey that was conducted at the time of application for a health handbook. The association between epilation...

  2. Mental health conditions in Korean atomic bomb survivors: a survey in Seoul

    OpenAIRE

    Koshimoto, Rika; Nakane, Hideyuki; Kim, Hyen; Kinoshita, Hirohisa; Moon, Deok Su; Ohtsuru, Akira; Bahn, Geonho; Shibata, Yoshisada; Ozawa, Hiroki; Yamashita, Shunichi

    2011-01-01

    More than 60 years have elapsed since the atomic bombings to Hiroshima and Nagasaki, and since all of the atomic bomb survivors have become old, the importance of caring their mental health has become increasing in Japan. Although approximately 70% of overseas atomic bomb are living in Korea, there have been quite few studies on their mental health. The objectives of the present study were to elucidate whether the mental health conditions of atomic bomb survivor in Korea are similar to those ...

  3. Foreign bodies radiographically demonstrated in atomic bomb survivors

    Energy Technology Data Exchange (ETDEWEB)

    Tamura, S.; Onitsuka, H.; Lee, K.K.; Shimizu, Y.; Russell, W.J.

    1978-02-01

    The prevalence of roentgenologically-detected foregin bodies among atomic bomb survivors was studied as an indicator of the A-bomb blast effects. Acupuncture was studied as an indicator of possible A-bomb-related abnormalities for which it was administered. All available roentgenograms of Adult Health Study (AHS) subjects which demonstrated foreign bodies were reviewed. The frequency of glass and metal foreign bodies and of acupuncture needles was analyzed in detail. Analyses were made by distance from the hypocenter, sex, age, body sites involved, and shielding at the time of the A-bomb (ATB). The presence of glass fragments correlated closely with distance from the hypocenter, with heavy shielding from the A-bombs, and with adulthood, and they were more frequent in the chest than in the hand and wrist. On the contrary, metal foreign bodies were more frequent in the hand and wrist than in the chest, and were not associated with distance from hypocenter or heavy shielding. The prevalence of acupuncture needles increased with age, but did not correlate with A-bomb dose.

  4. Radiation and cancer risk in atomic-bomb survivors.

    Science.gov (United States)

    Kodama, K; Ozasa, K; Okubo, T

    2012-03-01

    With the aim of accurately assessing the effects of radiation exposure in the Japanese atomic-bomb survivors, the Radiation Effects Research Foundation has, over several decades, conducted studies of the Life Span Study (LSS) cohort, comprising 93 000 atomic-bomb survivors and 27 000 controls. Solid cancer: the recent report on solid cancer incidence found that at age 70 years following exposure at age 30 years, solid cancer rates increase by about 35%  Gy(-1) for men and 58% Gy(-1) for women. Age-at-exposure is an important risk modifier. In the case of lung cancer, cigarette smoking has been found to be an important risk modifier. Radiation has similar effects on first-primary and second-primary cancer risks. Finally, radiation-associated increases in cancer rates appear to persist throughout life. Leukaemia: the recent report on leukaemia mortality suggests that radiation effects on leukaemia mortality persisted for more than 50 years. Moreover, significant dose-response for myelodysplastic syndrome was observed in Nagasaki LSS members even 40-60 years after radiation exposure. Future perspective: given the continuing solid cancer increase in the survivor population, the LSS will likely continue to provide important new information on radiation exposure and solid cancer risks for another 15-20 years, especially for those exposed at a young age. PMID:22394591

  5. Mortality of atomic bomb survivors predicted from laboratory animals

    Science.gov (United States)

    Carnes, Bruce A.; Grahn, Douglas; Hoel, David

    2003-01-01

    Exposure, pathology and mortality data for mice, dogs and humans were examined to determine whether accurate interspecies predictions of radiation-induced mortality could be achieved. The analyses revealed that (1) days of life lost per unit dose can be estimated for a species even without information on radiation effects in that species, and (2) accurate predictions of age-specific radiation-induced mortality in beagles and the atomic bomb survivors can be obtained from a dose-response model for comparably exposed mice. These findings illustrate the value of comparative mortality analyses and the relevance of animal data to the study of human health effects.

  6. Genetic analysis of children of atomic bomb survivors.

    OpenAIRE

    Satoh, C; Takahashi, N.; Asakawa, J; Kodaira, M; Kuick, R; Hanash, S M; Neel, J V

    1996-01-01

    Studies are under way for the detection of potential genetic effects of atomic bomb radiation at the DNA level in the children of survivors. In a pilot study, we have examined six minisatellites and five microsatellites in DNA derived from 100 families including 124 children. We detected a total of 28 mutations in three minisatellite loci. The mean mutation rates per locus per gamete in the six minisatellite loci were 1.5% for 65 exposed gametes for which mean parental gonadal dose was 1.9 Sv...

  7. Two cases of giant parathyroid adenoma in atomic bomb survivors

    International Nuclear Information System (INIS)

    In a study of parathyroid tumor among autopsy cases at RERF in Hiroshima, 16 cases of parathyroid adenoma were detected among 4,136 autopsies during 1961-77. Of these, two cases were giant adenoma (5 cm in diameter) accompanied by hyperparathyroidism. Both cases were atomic bomb survivors from Hiroshima. One was exposed to 55 rad at age 51 and died at age 71, and the other was exposed to 28 rad at age 45 and died at age 71. These two cases will be reported together with a review of the literature on parathyroid tumors developed following irradiation on the head and neck. (author)

  8. Review of dosimetry for the atomic bomb survivors

    International Nuclear Information System (INIS)

    This paper summarizes and discusses results of some 1980-1981 studies of neutron and γ-ray exposure to the atomic bomb survivors by W.E. Loewe and E. Mendelsohn of the Lawrence Livermore National Laboratory, D.C. Kaul and W.H. Scott of Science Applications, Inc., and J.V. Pace of the Oak Ridge National Laboratory. Some other special studies which are now underway to complete the review will also be discussed. The expert assistance of others in these special studies is being supported in part by the US Department of Energy and in part by the US Defense Nuclear Agency

  9. Impact on the Japanese atomic bomb survivors of radiation received from the bombs.

    Science.gov (United States)

    Cullings, Harry M

    2014-02-01

    The Radiation Effects Research Foundation (RERF) studies various cohorts of Japanese atomic bomb survivors, the largest being the Life Span Study (LSS), which includes 93,741 persons who were in Hiroshima or Nagasaki at the times of the bombings; there are also cohorts of persons who were exposed in utero and survivors' children. This presentation attempts to summarize the total impact of the radiation from the bombs on the survivors from both an individual perspective (both age-specific and integrated lifetime risk, along with a measure of life expectancy that describes how the risk affects the individual given age at exposure) and a group perspective (estimated numbers of excess occurrences in the cohort), including both early and late effects. As survivors' doses ranged well into the acutely lethal range at closer distances, some of them experienced acute signs and symptoms of radiation exposure in addition to being at risk of late effects. Although cancer has always been a primary concern among late effects, estimated numbers of excess cancers and hematopoietic malignancies in the LSS are a small fraction of the total due to the highly skewed dose distribution, with most survivors receiving small doses. For example, in the latest report on cancer incidence, 853 of 17,448 incident solid cancers were estimated to be attributable to radiation from the bombs. RERF research indicates that risk of radiation-associated cancer varies among sites and that some benign tumors such as uterine myoma are also associated with radiation. Noncancer late effects appear to be in excess in proportion to radiation dose but with an excess relative risk about one-third that of solid cancer and a correspondingly small overall fraction of cases attributable to radiation. Specific risks were found for some subcategories, particularly circulatory disease, including stroke and precedent conditions such as hypertension. Radiation-related cataract in the atomic bomb survivors is well known

  10. Radiation therapy among atomic bomb survivors, Hiroshima and Nagasaki

    International Nuclear Information System (INIS)

    In the continuing evaluations of atomic bomb survivors for late radiation effects, not only doses from the A-bombs but those from other radiation sources must be considered, for the latter may be concomitantly acting factors causing bias among these investigations. In the present study, among 73 Hiroshima and 22 Nagasaki Adult Health Study (AHS) subjects who reported receiving radiation therapy, from 1970 through 1979, the medical records of 72 and 20, respectively, were reviewed, and 41 Hiroshima and 14 Nagasaki subjects were confirmed to have received radiation therapy. The data obtained in the present study were pooled with those of the previous investigation on radiation therapy exposures of AHS subjects prior to 1970. A total of 190 subjects have been documented as receiving radiation therapy and their doses were estimated. Energies used in treatments and diseases treated are discussed. Malignancies developed subsequent to radiation therapy in seven cases; five after treatment for malignancies and two after treatment for benign diseases. Neoplasms of 12 AHS subjects may have been induced by earlier radiation therapy; 5 in the earlier study and 7 in the present one. These investigations underscore the need for continued documentation of exposures to ionizing radiation for medical reasons, especially from sources incurring relatively high doses. Bias in assessments of late radiation effects among A-bomb survivors can thus be avoided. (author)

  11. Increased somatic cell mutant frequency in atomic bomb survivors

    International Nuclear Information System (INIS)

    Frequencies of mutant T-cells in peripheral blood, which are deficient in the activity of hypoxanthine guanine phosphoribosyltransferase (HPRT) were determined for atomic bomb survivors by direct clonal assay using a previously reported method. Results from 30 exposed survivors (exposed to more than 1 rad) and 17 age- and sex-matched controls (exposed to less than 1 rad) were analyzed. The mean mutant frequency (Mf) in the exposed (5.2 x 10-6; range 0.8 - 14.4 x 10-6) was significantly higher than in controls (3.4 x 10-6; range 1.3 - 9.3 x 10-6), a fact not attributable to lower nonmutant cell cloning efficiencies in the exposed group since cell cloning efficiencies were virtually identical in both groups. An initial analysis of the data did not reveal a significant correlation between individual Mfs and individual radiation dose estimates when the latter were defined by the original, tentative estimates (T65D), even though there was a significant positive correlation of Mfs with individual frequency of lymphocytes bearing chromosome aberration. However, reanalysis using the newer revised individual dose estimates (DS86) for 27 exposed survivors and 17 controls did reveal a significant but shallow positive correlation between T-cell Mf values and individual exposure doses. These results indicate that HPRT mutation in vivo in human T-cells could be detected in these survivors 40 years after the presumed mutational event. (author)

  12. Children of the atomic bomb survivors: A genetic study

    International Nuclear Information System (INIS)

    This volume represents the results of over 40 years of study of the latent health effects on the survivors of the atomic bomb blasts. Planning for this research began in 1946 and data collection has been ongoing since 1948. The work represents the efforts of both US and Japanese agencies and presents 13 papers which the editors believe represent the best scientific information related to the genetic effects of radiation exposure. In general, the results presented here indicate that radiation exposure effects on reproductive cells are less than previously thought. The paper contained here examine that question in light of effects on pregnancy outcome, sex ratio, congenital defects, and early mortality of children. The papers also present helpful comparison of these results with the results seen in experimental radiation studies with animals. For anyone interested in the risks associated with radiation studies, this book represents a vital collection of information

  13. Accounting for neutron exposure in the Japanese atomic bomb survivors.

    Science.gov (United States)

    Cullings, Harry M; Pierce, Donald A; Kellerer, Albrecht M

    2014-12-01

    The Japanese atomic bomb survivors that were directly exposed to both γ rays and neutrons have been followed by the Radiation Effects Research Foundation (RERF). The estimation of the γ-ray risks requires some adjustment for the greater biological effect of the neutrons per unit dose. Because the small neutron doses and the predominant γ-ray doses are highly correlated, the neutron relative biological effectiveness (RBE) cannot be reliably estimated from the survivors' data and information from radiobiology must be invoked. As data became available on neutron doses, RERF has used a constant neutron RBE value of 10, even though radiobiological studies indicate that the RBE values appear to have considerably larger values at low doses. The approximation RBE = 10 assumes that if the RBE is variable it takes roughly this value in the range of total dose most relevant for linear risk estimation, namely about 1 Gy. We consider some possible RBE functions to explain the correct use and the impact of a dose-dependent RBE. However, we do not advocate any particular choice or even that a variable RBE be employed. Rather we show that the assumed neutron RBE, within a wide range of choices, is far less important to the outcome of risk assessment of the RERF data than generally believed. Some of these misperceptions have been related to the consideration of variable RBE functions, and without due attention to the fact that in the case of the A-bomb survivors' data, the mixed field of neutrons and γ rays must be considered. Therefore, the RBE value of neutrons is much lower than the RBE in pure neutron fields that are used in radiobiological experiments. Thus, applying the pure neutron field RBE to the mixed-field A-bomb radiation can lead to an overestimation of the actual neutron RBE for moderate total dose levels of 1 Gy by a factor of more than four. While in a pure neutron exposure the RBE depends on the neutron dose, in the mixed field it depends on both components of

  14. Proliferative and nonproliferative breast disease in atomic-bomb survivors

    International Nuclear Information System (INIS)

    The risk of female breast cancer in association with radiation exposure is well established, on the basis of follow-up studies of the atomic-bomb survivors and other exposed populations. This association is especially strong for women exposed before age 20 yr and appears to be much weaker among women exposed after age 40 yr. In this study, breast-tissue autopsy samples from high-dose and low-dose individuals in the Radiation Effects Research Foundation Life Span Study sample were examined in detail to determine whether nonproliferative or proliferative breast lesions are associated with radiation exposure. The results suggest that proliferative disease in general and atypical hyperplasia in particular are associated with radiation exposure and that the risk is strongest for subjects who were ages 40-49 yr at the time of the bombings. It is hypothesized that this finding may be related to the age dependence of radiation-induced breast cancer, in the sense that potential cancers reflecting early-stage changes induced at these ages by radiation exposure may receive too little hormonal promotion to progress to frank cancers. (author)

  15. The children of atomic bomb survivors: a synopsis.

    Science.gov (United States)

    Schull, William J

    2003-12-01

    When the atomic bombing of Hiroshima and Nagasaki occurred in the summer of 1945, most members of the public presumed that many of the children conceived by the survivors would be grossly deformed or seriously damaged in other ways as a consequence of radiation-induced mutations. Although the experimental data then available, largely limited to studies of Drosophila melanogaster, the common fruit fly, did not support this perception, the limitations of the data and the depth of public concern warranted a careful follow-up of the children born to the survivors. To this end a surveillance was begun in 1947 of all pregnancy outcomes after 20 weeks of gestation in these two cities. Over the half century subsequent to the initiation of this surveillance, some 80-odd thousand pregnancy outcomes have been studied and a variety of potential indicators of mutational damage measured. This report summarises the findings of these studies and offers an estimate of the genetic risk based on these findings. PMID:14750686

  16. The children of atomic bomb survivors: a synopsis

    Energy Technology Data Exchange (ETDEWEB)

    Schull, William J [Human Genetics Center, School of Public Health, University of Texas Health Science Center, Houston, TX 77225 (United States)

    2003-12-01

    When the atomic bombing of Hiroshima and Nagasaki occurred in the summer of 1945, most members of the public presumed that many of the children conceived by the survivors would be grossly deformed or seriously damaged in other ways as a consequence of radiation-induced mutations. Although the experimental data then available, largely limited to studies of Drosophila melanogaster, the common fruit fly, did not support this perception, the limitations of the data and the depth of public concern warranted a careful follow-up of the children born to the survivors. To this end a surveillance was begun in 1947 of all pregnancy outcomes after 20 weeks of gestation in these two cities. Over the half century subsequent to the initiation of this surveillance, some 80-odd thousand pregnancy outcomes have been studied and a variety of potential indicators of mutational damage measured. This report summarises the findings of these studies and offers an estimate of the genetic risk based on these findings. (review)

  17. Malignant lymphoma and multiple myeloma in atomic-bomb survivors

    International Nuclear Information System (INIS)

    Of autopsies performed from 1956 to 1976 in Hiroshima Atomic Bomb Hospital, 22 cases of reticulo-sarcoma, 4 cases of lymphosarcoma, 6 cases of Hodgkin's disease, and 9 cases of multiple myeloma were observed in atomic bomb survivors. In regard to the relationship between exposure distance and the number of autopsied cases, the nearer the exposure distance to the center of explosion, the higher the incidence of reticulo-sarcoma in male patients only. Since 1966 cases of malignant lymphoma and multiple myeloma increased with an increase in the number of autopsied cases. An increase in incidences of lymphoma and multiple myeloma was marked especially in the group which entered the city after the explosion. There were more cases of malignant lymphoma in aged patients in the exposed group than in the non-exposed group. Lymphosarcoma and Hodgkin's disease were observed more often in women in the exposed group than in men. Many cases of reticulo-sarcoma in the digestive tract, especially primary stomach reticulo-sarcoma, were observed in the group which was exposed at places over 2 km from the center of explosion and in the exposed group which entered the city after the explosion. Four cases of leukemic reticulo-sarcoma were observed. With respect to histological types of reticulosarcoma, an undifferentiated type was observed in the group exposed at places over 2 km from the center of explosion and in the exposed group which entered the city after the explosion. Incidence of multiple myeloma was high in the group exposed at places within 2 km of the center of explosion. Three cases in which myeloma cells showed a tendency toward diffuse infiltration and proliferation within the bone marrow were observed in the exposed group. (Tsunoda, M.)

  18. [Cohort studies of the atomic bomb survivors at the Radiation Effects Research Foundation].

    Science.gov (United States)

    Ozasa, Kotaro

    2012-03-01

    The Radiation Effects Research Foundation has been evaluating the risk of atomic bomb radiation for various diseases since the beginning of its former organization, the Atomic Bomb Casualty Commission. Cohorts of atomic-bomb survivors, in-utero survivors, and survivors' offspring have been followed up. The risk of all solid cancers at 1 Gy was estimated as ERR = 0.47 and EAR = 52/10,000 person-years for people who were exposed at 30 years of age and had reached 70 years of age, based on the cancer incidence during 1958-1998. The risk seemed to be increased in the in-utero survivors, but was rather lower than the risk for the survivors exposed at a young age. Effects on the offspring of survivors have not been shown to be significant. Continuing the research is important in order to more accurately estimate and understand radiation-induced health effects. PMID:22514915

  19. Biological Profiles of Korean Atomic Bomb Survivors in Residence at Daegu and Kyungbuk, Republic of Korea

    OpenAIRE

    Jhun, Hyung-Joon; Kim, Byoung-Gwon; Park, Jong-Tae; Kim, Su-Young; Koo, Bon-Min; Kim, Jin-Kook

    2008-01-01

    In 1945, many Koreans, in addition to Japanese, were killed or injured by the atomic bombs dropped on Hiroshima and Nagasaki, Japan. This study compared the biological profiles of Korean atomic bomb survivors in residence at Daegu and Kyungbuk, Republic of Korea with those of a representative sample of Koreans obtained during a similar period. We evaluated anthropometric measurements, blood pressure, blood cell counts, blood chemistry, and urinalysis of survivors (n=414) and age- and sex-matc...

  20. The incidence of leukemia, lymphoma, and multiple myeloma among atomic bomb survivors: 1950 – 2001

    OpenAIRE

    Hsu, Wan-Ling; Preston, Dale L.; Soda, Midori; Sugiyama, Hiromi; Funamoto, Sachiyo; Kodama, Kazunori; Kimura, Akiro; Kamada, Nanao; Dohy, Hiroo; Tomonaga, Masao; Iwanaga, Masako; Miyazaki, Yasushi; Cullings, Harry M.; Suyama, Akihiko; Ozasa, Kotaro

    2013-01-01

    A marked increase in leukemia risks was the first and most striking late effect of radiation exposure seen among the Hiroshima and Nagasaki atomic bomb survivors. This paper presents analyses of radiation effects on leukemia, lymphoma, and multiple myeloma incidence in the Life Span Study cohort of atomic bomb survivors updated 14 years since the last comprehensive report on these malignancies. These analyses make use of tumor- and leukemia-registry-based incidence data on 113,011 cohort memb...

  1. Incidence of multiple primary cancers in Nagasaki atomic bomb survivors: association with radiation exposure.

    OpenAIRE

    Nakashima, Masahiro; Kondo, Hisayoshi; Miura, Shiro; Soda, Midori; Hayashi, Tomayoshi; Matsuo, Takeshi; Yamashita, Shunichi; Sekine, Ichiro

    2008-01-01

    To assess the effects of atomic bomb radiation on the incidence of multiple primary cancers (MPC), we analyzed the association between the incidence of second primary cancers in survivors of the atomic bombing of Nagasaki, and exposure distance. The incidence rate (IR) of a second primary cancer was calculated and stratified by the distance from the hypocenter and age at the time of bombing for the years 1968 through 1999. The IR of the first primary cancer was also calculated and compared wi...

  2. Serum autoantibodies in atomic bomb survivors, Hiroshima and Nagasaki

    International Nuclear Information System (INIS)

    In order to evaluate delayed effects of radiation on humoral immunity, an attempt was made to detect antibodies in the serum of atomic bomb survivors against kidney, liver, and parietal cells from rats. The following results were observed. Comparing by sex and age, the detection frequency of antibodies increased significantly for all three organs in the male group only. Analysis of changes in antibody detection frequencies by age and exposure dose without considering sex showed that the rates for those exposed to 100 + rad showed a trend to increase with age for all three organs (P < 0.01). However, in the 0 rad group, a significant trend to increase with age was noted for antikidney and antiliver antibodies only (P < 0.01 for both). Analysis of changes in antibody detection frequencies by sex, age, and exposure dose showed that the detection frequencies increased significantly with age for all three organs in males exposed to 100 + rad (P < 0.05), but only the antiliver antibody frequency increased significantly with age in males in the 0 rad exposure group. Females failed to show any statistical changes in any exposure group. (author)

  3. Effects of radiation on the incidence of prostate cancer among Nagasaki atomic bomb survivors.

    Science.gov (United States)

    Kondo, Hisayoshi; Soda, Midori; Mine, Mariko; Yokota, Kenichi

    2013-10-01

    Atomic bomb survivors have been reported to have an increased risk of some cancers, especially leukemia. However, the risk of prostate cancer in atomic bomb survivors is not known to have been examined previously. This study examined the association between atomic bomb radiation and the incidence of prostate cancer among male Nagasaki atomic bomb survivors. The subjects were classified by distance from the hypocenter into a proximal group (atomic bomb survivors who were alive in 1996. The Cox proportional hazard model was used to estimate the risk of prostate cancer development, with adjustment for age at atomic bomb explosion, attained age, smoking status, and alcohol consumption. Compared with the distal group, the proximal group had significant increased risks of total, localized, and high-grade prostate cancer (relative risk and 95% confidence interval: 1.51 [1.21-1.89]; 1.80 [1.26-2.57]; and 1.88 [1.20-2.94], respectively). This report is the first known to reveal a significant relationship between atomic bomb radiation and prostate cancer. PMID:23859763

  4. Association of Acute Radiation Syndrome and Rain after the Bombings in Atomic Bomb Survivors.

    Science.gov (United States)

    Ozasa, K; Sakata, R; Cullings, H M; Grant, E J

    2016-06-01

    Acute radiation-induced symptoms reported in survivors after the atomic bombings in Hiroshima and Nagasaki have been suspected to be associated with rain that fell after the explosions, but this association has not been evaluated in an epidemiological study that considers the effects of the direct dose from the atomic bombs and other factors. The aim of this study was to evaluate this association using information from a fixed cohort, comprised of 93,741 members of the Life Span Study who were in the city at the time of the bombing. Information on acute symptoms and exposure to rain was collected in surveys conducted by interviewers, primarily in the 1950s. The proportion of survivors developing severe epilation was around 60% at levels of direct radiation doses of 3 Gy or higher and less than 0.2% at levels <0.005 Gy regardless of reported rain exposure status. The low prevalence of acute symptoms at low direct doses indicates that the reported fallout rain was not homogeneously radioactive at a level sufficient to cause a substantial probability of acute symptoms. We observed that the proportion of reported acute symptoms was slightly higher among those who reported rain exposure in some subgroups, however, suggestions that rain was the cause of these reported symptoms are not supported by analyses specific to the known areas of radioactive fallout. Misclassification of exposure and outcome, including symptoms due to other causes and recall bias, appears to be a more plausible explanation. However, the insufficient and retrospective nature of the available data limited our ability to quantify the attribution to those possible causes. PMID:27223827

  5. Hyperparathyroidism among atomic bomb survivors in Hiroshima, 1986-88

    International Nuclear Information System (INIS)

    During the two-year period from August 1986 to July 1988, the prevalence of hyperparathyroidism (HPT) was determined among A-bomb survivors and unexposed control subjects in Hiroshima. The diagnosis of HPT was determined biochemically, based upon the presence of consistent hypercalcemia and elevated serum parathyroid hormone levels. Among a population of 4,675 individuals (1,527 males, 3,148 females), primary HPT was diagnosed in 22 (3 males, 19 females). Of these, 8 underwent surgery, of whom 6 had a single parathyroid adenoma and 2 had parathyroid hyperplasia. HPT was more prevalent among the A-bomb survivors who received higher radiation doses (p <.001 for linear trend). The prevalence rates predicted from the model were 0.204% (±0.094%) at 0 Gy and 0.893% (±0.237%) at 1 Gy. The background rate of HPT did not differ significantly by sex or by age at the time of the bombing, although the effect of radiation exposure was greater for individuals exposed at a younger age (p <.01). (author)

  6. The prognosis of pancreatic carcinoma in atomic bomb survivors

    Energy Technology Data Exchange (ETDEWEB)

    Kawanishi, Masahiro; Munaka, Masaki (Hiroshima Univ. (Japan). Research Inst. for Nuclear Medicine and Biology); Okamoto, Sukeyoshi; Kajiyama, Goro

    1992-03-01

    Prognosis of pancreatic carcinoma in 28 Hiroshima A-bomb survivors was compared with that in background- and tumor size-matched non-exposed patients living in Hiroshima. A-bomb survivors consisted of 13 exposed within 2,000 m from the hypocenter, 12 who had entered the city within 3 days after A-bombing, and 3 not clarified in detail. Survival time was significantly prolonged when tumor resection or surgical internal fistula for obstructive jaundice was performed. The significant therapeutic factor was thus adjusted by using the Cox model to clarify the difference in cumulative survival rates between the exposed and non-exposed groups of pancreatic cancer patients. Median survival was 120 days in the exposed group and 186 days in the non-exposed group. The corresponding figures for 75% and 25% cumulative survival rates were 175 days and 75 days in the exposed group and 238 days and 120 days in the non-exposed group. Prognosis was worse in the exposed group than the non-exposed group. (N.K.).

  7. Hot-spring cure of atomic-bomb survivors, 16

    Energy Technology Data Exchange (ETDEWEB)

    Ouchi, Tamon (Beppu Genbaku Senta (Japan))

    1984-03-01

    Though a cold winter with snowfalls, in the fiscal year 1983, the number of the atomic-bomb sufferers using the Beppu Atomic-bomb Center (a medical hot spring) was large in January and February, 1984; throughout the fiscal year, the total number was about 3,800 persons. The diseases of the sufferers, mostly in locomotion organs, are such as osteoarthritis of spine, lame hip and knee arthropathy. Being the typical diseases for which hot spring treatment is good, the effect is clear, and those desiring to enter the Center twice in a year are increasing. The situation of usage of the Center from April, 1983, to March, 1984, is described.

  8. Patterns of Excess Cancer Risk among the Atomic Bomb Survivors

    Science.gov (United States)

    Pierce, Donald A.

    1996-05-01

    I will indicate the major epidemiological findings regarding excess cancer among the atomic-bomb survivors, with some special attention to what can be said about low-dose risks. This will be based on 1950--90 mortality follow-up of about 87,000 survivors having individual radiation dose estimates. Of these about 50,000 had doses greater than 0.005 Sv, and the remainder serve largely as a comparison group. It is estimated that for this cohort there have been about 400 excess cancer deaths among a total of about 7800. Since there are about 37,000 subjects in the dose range .005--.20 Sv, there is substantial low-dose information in this study. The person-year-Seivert for the dose range under .20 Sv is greater than for any one of the 6 study cohorts of U.S., Canadian, and U.K. nuclear workers; and is equal to about 60% of the total for the combined cohorts. It is estimated, without linear extrapolation from higher doses, that for the RERF cohort there have been about 100 excess cancer deaths in the dose range under .20 Sv. Both the dose-response and age-time patterns of excess risk are very different for solid cancers and leukemia. One of the most important findings has been that the solid cancer (absolute) excess risk has steadily increased over the entire follow-up to date, similarly to the age-increase of the background risk. About 25% of the excess solid cancer deaths occurred in the last 5 years of the 1950--90 follow-up. On the contrary most of the excess leukemia risk occurred in the first few years following exposure. The observed dose response for solid cancers is very linear up to about 3 Sv, whereas for leukemia there is statistically significant upward curvature on that range. Very little has been proposed to explain this distinction. Although there is no hint of upward curvature or a threshold for solid cancers, the inherent difficulty of precisely estimating very small risks along with radiobiological observations that many radiation effects are nonlinear

  9. Whole-blood phagocytic and bactericidal activities of atomic bomb survivors, Hiroshima and Nagasaki

    International Nuclear Information System (INIS)

    This in vitro study evaluated the phagocytic and bactericidal activities of leukocytes in aliquots of whole blood from Hiroshima and Nagasaki atomic bomb survivors for Staphylococcus aureus. The data were analyzed by multiple linear regression. Any significant effects of exposure to A-bomb radiation could not be detected for both phagocytic and bactericidal activities of whole blood from A-bomb survivors. In addition, there were no significant effects of age categories, sex or city, except in neutrophil counts. (J.P.N.)

  10. Medical Database for the Atomic-Bomb Survivors at Nagasaki University

    OpenAIRE

    Mori, Hiroyuki; Mine, Mariko; Kondo, Hisayoshi; Okumura, Yutaka

    1992-01-01

    The Scientific Data Center for Atomic-Bomb Disasters at Nagasaki University was established in 1974. The database of atomicbomb survivors has been in operation since 1977. The database is composed of following 6 physical database : (1) Fundamental information database. (2) Atomic-Bomb Hospital database, (3) Pathological database, (4) Household reconstruction database, (5) Second generation database, and (6) Address database. We review the current contents of the database for its further appli...

  11. Food habits in atomic bomb survivors suffering from malignant neoplasms

    International Nuclear Information System (INIS)

    Food habits were surveyed in patients admitted to 13 hospitals in Nagasaki prefecture and other prefectures to compare the incidence of malignant neoplasms according to the food intake between atomic bomb exposed group and non-exposed group. The incidence of malignant neoplasms was significantly higher in male patients having the low intake of milk and salted fish than in those having the high intake of them in atomic bomb exposed group, while it was significantly higher in male patients having the low intake of potatoes and milk and in female patients having the low intake of boiled fish paste than in those having the high intake of them in non-exposed group. (Namekawa, K.)

  12. Clinical studies of lung cancer of atomic bomb survivors, 4

    International Nuclear Information System (INIS)

    A comparative study was made on complications of lung cancer in 188 A-bomb survivors (group 1) and 327 non-exposed patients (group 2) treated from 1972 through 1982. The incidence of complications was higher in group 1 (32 %) than in group 2 (20 %). Complications occurred most frequently in the respiratory system, followed by those in the circulatory system and diabetes mellitus in both groups. Patients with complications in the respiratory, circulatory, or nervous system tended to be inoperable. For patients with clinical stage I or II developing complications, the prognosis was worse as compared with those without complications. Long-term survival can be achieved in two patients with early stage lung cancer in whom surgical treatment was impossible because of the association of severe complications. (Namekawa, K.)

  13. Non-cancer diseases of Korean atomic bomb survivors in residence at Hapcheon, Republic of Korea.

    Science.gov (United States)

    Ju, Young-Su; Jhun, Hyung-Joon; Kim, Jung-Bum; Kim, Jin-Kook

    2006-06-01

    Many Koreans, in addition to Japanese, were killed or injured by the atomic bombs detonated over Hiroshima and Nagasaki, Japan, in 1945. Our study examined noncancer diseases of Korean A-bomb survivors in residence at Hapcheon, Republic of Korea and evaluated whether they had significantly higher prevalence of noncancer diseases than non-exposed people. We evaluated a number of tests, including anthropometric measurements, blood pressure, blood chemistry, hepatitis B surface antigen, and urinalysis, of survivors (n=223) and controls (n=372). Univariate analysis revealed significantly lower fasting glucose and creatinine, and higher diastolic blood pressure, aspartate aminotransferase, alanine aminotransferase, and blood urea nitrogen levels in the survivors than in the controls. The calculation of crude prevalence ratios (PRs) revealed that A-bomb survivors had a significantly higher prevalence of hypertension (PR, 1.16; 95% CI, 1.00-1.35) and chronic liver disease (2.20; 1.59-3.06) than controls. After adjusting for covariates (age, sex, body mass index, marital status, education, alcohol consumption, and smoking), A-bomb survivors had a significantly higher prevalence of hypertension (1.24; 1.06-1.44), chronic liver disease (2.07; 1.51-2.84), and hypercholesterolemia (1.79; 1.11-2.90) than controls. This study suggests that A-bomb exposure is associated with a higher prevalence of non-cancer diseases in Korean survivors. PMID:16778377

  14. The association between chronic kidney disease and cardiovascular disease risk factors in atomic bomb survivors.

    Science.gov (United States)

    Sera, Nobuko; Hida, Ayumi; Imaizumi, Misa; Nakashima, Eiji; Akahoshi, Masazumi

    2013-01-01

    Atomic bomb (A-bomb) radiation is associated with cardiovascular disease (CVD) and metabolic CVD risk factors. Chronic kidney disease (CKD) is also known to be a risk factor for CVD and little is known whether CKD is associated with A-bomb radiation. To examine whether CKD is associated with CVD risk factors or with A-bomb radiation in A-bomb survivors, we classified renal dysfunction in 1,040 A-bomb survivors who were examined in 2004-2007 as normal [n = 121; estimated glomerular filtration rate (eGFR) ≥ 90 ml/min/1.73 m(2)]; mild (n = 686; eGFR 60-89 ml/min/1.73 m(2)); moderate (n = 217; eGFR 30-59 ml/min/1.73 m(2)); or severe (n = 16; eGFR bomb radiation. Hypertension [odds ratio (OR), 1.57; 95% confidence interval (CI), 1.12-2.20, P = 0.009]; DM (OR, 1.79; 95% CI, 1.23-2.61, P = 0.002); hyperlipidemia (OR, 1.55; 95% CI, 1.12-2.14, P = 0.008); and MetS (OR, 1.86; 95% CI, 1.32-2.63, P bomb survivors. PMID:23148507

  15. Results of lung cancer screening in atomic bomb survivors

    International Nuclear Information System (INIS)

    Risk of lung cancer in A-bomb survivors is reportedly increased. The screening in the title has been conducted since 1988 and this report summarizes its results of the latest 6-year term (2004-2009). The total number of subjects who visited authors' facility for the screening in the period was 39,147 men (average age 70.6 y) and 45,351 women (71.8 y), of the age range of 60-89 y. The screening results of the cancer were examined concerning with sex, age and exposure situation. As well, the relationship between the found cancer incidence and exposure in never, formerly and currently smoking subjects were also examined. Exposure situation was divided in 3 groups of the exposure by entrance in the city/by other reasons, within 2 km close (Close, C) to, and out of 2.1 km afar (Distant, D) from, the city. Statistic analysis was performed by Chi-squire and/or Fisher's exact test. The index of positive finding in the screening of the lung cancer per 1,000 subjects was the highest in C men of ages 70s, 2.88 subjects, which was statistically significant from 0.85 in D men of the same generation. In current smokers, the index 5.40 in C men of ages 70s was significantly higher than 0.90 in D men of the same generation. Overall, positive results tended to be high in survivors of C regardless to sex and smoking, and was significantly high in current smokers of C as above, both implying the particular necessity of promotion to stop smoking in survivors. (T.T.)

  16. Non-cancer Diseases of Korean Atomic Bomb Survivors in Residence at Hapcheon, Republic of Korea

    OpenAIRE

    Ju, Young-Su; Jhun, Hyung-Joon; Kim, Jung-Bum; Kim, Jin-Kook

    2006-01-01

    Many Koreans, in addition to Japanese, were killed or injured by the atomic bombs detonated over Hiroshima and Nagasaki, Japan, in 1945. Our study examined non-cancer diseases of Korean A-bomb survivors in residence at Hapcheon, Republic of Korea and evaluated whether they had significantly higher prevalence of non-cancer diseases than non-exposed people. We evaluated a number of tests, including anthropometric measurements, blood pressure, blood chemistry, hepatitis B surface antigen, and ur...

  17. Mathematical phantoms for use in reassessment of radiation doses to Japanese atomic-bomb survivors

    International Nuclear Information System (INIS)

    In 1972 committees of the United Nations and the US National Academy of Sciencs emphasized the need for organ dose estimates on the Japanese atomic-bomb survivors. These estimates were then supplied by workers in Japan and the US, and they were used with the so-called T65D estimates of a survivor's radiation exposure to assess risk from radiation. Recently the T65D estimates have been questioned, and programs for reassessment of atomic-bomb radiation dosimetry have been started in Japan and the US. As a part of this new effort a mathematical analogue of the human body (or ''mathematical phantom''), to be used in estimating organ doses in adult survivors, is presented here. Recommendations on organ dosimetry for juvenile survivors are also presented and discussed. 57 refs., 10 figs., 6 tabs

  18. Mortality statistics among atomic bomb survivors in Hiroshima Prefecture. 1968-1972

    Energy Technology Data Exchange (ETDEWEB)

    Kurihara, M.; Munaka, M.; Hayakawa, N.; Yamamoto, H.; Ueoka, H.; Ohtaki, M. (Hiroshima Univ. (Japan). Research Inst. for Nuclear Medicine and Biology)

    1981-12-01

    In a comparative analysis of mortality among atomic bomb survivors versus the non-exposed, both resident in Hiroshima Prefecture, it was found that in addition to leukaemia, malignant lymphoma, multiple myeloma, and cancers of the thyroid gland, breast, lung, esophagus, stomach, urinary organs and salivary gland which have been reported from the past to be elevated in risk among atomic bomb survivors, cancers of the colon, larynx, accessory sinuses, uterus, ovary and testis, diseases of the blood, cirrhosis of liver, hypertensive disease and diabetes mellitus were elevated in risk, but the risk of cerebrovascular disease, heart disease, peptic ulcer, gastroenteritis, senility, and accidents was lower than the non-exposed. The relationship of atomic bomb exposure to the relative risk of cancers of the lung, breast, uterus, and testis could be readily explained, but the relationship between atomic bomb exposure and the relative risk of cancers of many other sites, diseases of the blood, and other causes of death was inconsistent. One of the reasons why the risk of senility was low and the risk of diseases of the blood, malignant neoplasms, diabetes mellitus, and hypertensive disease was high is considered to be the higher diagnostic accuracy in atomic bomb survivors.

  19. Subclinical hyperthyroidism (Sh) in atomic-bomb survivors in Japan

    International Nuclear Information System (INIS)

    Full text: Purpose/Background Subclinical hyperthyroidism (Sh) is defined as a biochemical abnormality characterized by a subnormal level of TSH with otherwise normal thyroid tests (F T3, F T4) and no clinical symptoms. There are only a small number of cross-sectional studies on the prevalence of Sh. With the improvement of the sensitivity of TSH assay, it has become possible to survey the clinical significance of Sh. With regard to both Sh and subclinical hypothyroidism, discussions are being focused on such as the necessity of treatment. In order to elucidate the clinical significance of Sh, examination data of A-bomb survivors in Hiroshima and Nagasaki were analyzed. Subjects and Method Between 2000 and 2003, of 4,090 A-bomb survivors (1,352 males and 2,738 females with average age of 70.7), 75 individuals (1.83%) with Sh were found who had normal Free T4 (0.71∼1.51 ng/dL) and TSH<0.45 m U/L. Analysis was limited to those who had not taken antithyroid drugs or thyroxin, and the Sh group (n=35; 9 males and 26 females) was compared with a control group with TSH:0.45∼4.5 m U/L (Group C; N=3,243; 1,109 males and 2,134 females). Result: Nine individuals had TSH<0.1 m U/L. In the Sh group, six individuals were TPO antibody-positive (17%) and 14 were TG antibody-positive (40%); hence, TG antibody-positive was significantly greater in number (p=0.0096). Hematological biochemical tests showed no significant difference between the two groups. Electrocardiograms indicated that more individuals had atrial fibrillation [p=0.028; Odds ratio (OR)=3.98; 95% Confidential interval (CI)=1.2-13.7] or ventricular premature contraction [p=0.016; OR=3.29; 95% CI=1.3-8.6] in the Sh group. In terms of the presence or absence of diabetes, dyslipidemia, hypertension, and hyperuricemia, there was no difference between the two groups. One individual from the Sh group was confirmed to have Graves' disease two years later. Conclusion: Since more individuals in the Sh group were thyroid

  20. Axial length of atomic bomb survivors in Nagasaki

    Energy Technology Data Exchange (ETDEWEB)

    Wakiyama, Harumi; Kishikawa, Yasuhiro; Imamura, Naoki [Nagasaki Atomic Bomb Hospital (Japan); Amemiya, Tsugio [Nagasaki Univ. (Japan). School of Medicine

    2002-03-01

    We reviewed a series of 778 patients who had cataract surgery during the past 4 years at the Nagasaki Atomic Bomb Memorial Hospital. We evaluated the history of exposure to radiation by atomic bomb in 1945, axial length and state of refraction. All were born before 1945. The series comprised 263 males and 515 females. Their ages averaged 76.5{+-}8.6 years. History of exposure to radiation was present in 356 patients. The remaining 422 patients served as control. There was no difference in the type of cataract between the two groups. High myopia was present in 11 irradiated patients (3.2%) and in 24 patients in the control group (6.0%). The difference was not significant (p=0.083). There was no high myopia among 24 patients who were aged 18 years or less at the time of radiation and who were within 2 km from the epicenter. No difference was present regarding the axial length between the two groups or between both sexes. The present result is not definitive because ''irradiated group'' would include those with little or no exposure and because precise data has not been available about the dosis of radiation. (author)

  1. Survey of radiation doses received by atomic-bomb survivors residing in the United States

    International Nuclear Information System (INIS)

    A survey has been completed of 300 of an estimated 500 to 750 survivors of the atomic bombings in Hiroshima and Nagasaki who reside in the United States. Distributions with respect to age, sex, citizenship status, distance from the hypocenter at the time of bombing, and dose from immediate weapon radiation have been tabulated from the results and are presented for this group of 300 survivors. Also presented are survey results concerning exposures to residual radiation from fallout and neutron-induced radioactivity in the areas adjacent to the hypocenter

  2. Organ doses to atomic bomb survivors from radiological examinations at the Radiation Effects Research Foundation

    International Nuclear Information System (INIS)

    When estimating the risks of oncogenesis and cancer mortality as a result of atomic bomb radiation exposure, medical X-ray doses received by the A-bomb survivors must also be estimated and considered. Using a phantom human, we estimated the X-ray doses received by A-bomb survivors during routine biennial medical examinations conducted at RERF as part of the long-term Adult Health Study (AHS), since these examinations may represent about 45 % of the survivors' total medical irradiations. Doses to the salivary glands, thyroid gland, lung, breast, stomach and colon were measured using thermoluminescent dosimeters. The results reported here will aid in estimating organ doses received by individual AHS participants. (author)

  3. Radiation exposure and circulatory disease risk: Hiroshima and Nagasaki atomic bomb survivor data, 1950-2003

    OpenAIRE

    Shimizu, Yukiko; Kodama, Kazunori; Nishi, Nobuo; Kasagi, Fumiyoshi; Suyama, Akihiko; Soda, Midori; Grant, Eric J; Sugiyama, Hiromi; Sakata, Ritsu; Moriwaki, Hiroko; Hayashi, Mikiko; Konda, Manami; Shore, Roy E.

    2010-01-01

    Objective To investigate the degree to which ionising radiation confers risk of mortality from heart disease and stroke. Design Prospective cohort study with more than 50 years of follow-up. Setting Atomic bomb survivors in Hiroshima and Nagasaki, Japan. Participants 86 611 Life Span Study cohort members with individually estimated radiation doses from 0 to >3 Gy (86% received

  4. Cell biological study in multiple myeloma among atomic bomb survivors

    International Nuclear Information System (INIS)

    The study was undertaken to determine differences in the expression of cell surface antigens in normal plasma cells and mature myeloma cells. The subjects were 20 patients with multiple myeloma, including 5 A-bomb survivors. Seven normal persons, four with chronic tonsillitis, one with idiopathic thrombocytopenic purpura, and two with chronic lymphadenitis served as controls. In the group of myeloma cells, 12 showed mature myeloma cells of VLA-4+/VLA-5+/MPC-1+, and the other 8 showed precursor myeloma cells of VLA-4+/VLA-5-/MPC-1-. In terms of CD56 and CD19, CD56+/CD19- were seen in 13 patients, CD56-/CD19- in 5, and CD56+/CD19+ in 2; none of the patients showed phenotype of CD56-/CD19+. In the control group, all showed VLA-4+/VLA-5+/MPC-1+/CD44+/CD56-/CD19+; phenotype of normal plasma cells was CD38++/CD56-/CD19+ alone, which was not seen in the group of mature myeloma cells. Thus, this type is considered characteristic to normal plasma cells. These findings revealed that the difference in the expression of CD56 and CD19 aids in the identification of myeloma cells from normal plasma cells. (N.K.)

  5. Thyroid cancer incidence among atomic bomb survivors, 1958-79

    International Nuclear Information System (INIS)

    One hundred and twelve cases of thyroid cancer diagnosed during the period 1958-79 among the extended Life Span Study cohort in Hiroshima and Nagasaki were studied. There was a statistically significant association between thyroid cancer incidence and exposure to atomic bomb radiation. The adjusted excess relative risk (ERR) per gray was 1.1 (95% confidence interval=0.3-2.5) and the adjusted absolute risk per 104 PYGy was 0.59 (95% confidence interval=0.2-1.7). Based on a comparison of the deviances obtained from relative and absolute risk models, a simple linear relative risk model appeared to fit the data better than an absolute risk model; however, it would not be appropriate to conclude that the data conform strictly to a relative risk pattern. The incidence of thyroid cancer among the members of the Adult Health Study (AHS) population, who have received biennial medical examinations at the Atomic Bomb Casualty Commission and its successor the Radiation Effects Research Foundation, since 1958, was 70% higher than that among the rest of the extended LSS cohort after adjustments for city, sex, log age, calendar year, and Dosimetry System 1986 dose. There was no significant difference between the slope of the dose-response curve for AHS and non-AHS participants, although the estimated ERRs at 1 Gy for the AHS and non-AHS population were 1.6 and 0.3, respectively. The elevated risk appeared to be confined to women, and there was an increasing risk with decreasing attained age and age at exposure. (J.P.N.)

  6. Pathological and Epidemiologic Study of Gastric Cancer in Atomic Bomb Survivors, Hiroshima and Nagasaki, 1959-77

    OpenAIRE

    Matsuura, Hiroo; Yamamoto, Tsutomu; Sekine, Ichiro; Ochi, Yoshimiti; Ohtake, Masanori

    1984-01-01

    A study to elucidate the effects of atomic bomb (A-bomb) radiation exposure on the incidence of stomach cancer was conducted on 79,856 A-bomb survivors included in the Life Span Study sample for whom dose estimates are available. From cases diagnosed duri

  7. Epidemiological research on radiation-induced cancer in atomic bomb survivors

    Science.gov (United States)

    Ozasa, Kotaro

    2016-01-01

    The late effects of exposure to atomic bomb radiation on cancer occurrence have been evaluated by epidemiological studies on three cohorts: a cohort of atomic bomb survivors (Life Span Study; LSS), survivors exposed in utero, and children of atomic bomb survivors (F1). The risk of leukemia among the survivors increased remarkably in the early period after the bombings, especially among children. Increased risks of solid cancers have been evident since around 10 years after the bombings and are still present today. The LSS has clarified the dose–response relationships of radiation exposure and risk of various cancers, taking into account important risk modifiers such as sex, age at exposure, and attained age. Confounding by conventional risk factors including lifestyle differences is not considered substantial because people were non-selectively exposed to the atomic bomb radiation. Uncertainty in risk estimates at low-dose levels is thought to be derived from various sources, including different estimates of risk at background levels, uncertainty in dose estimates, residual confounding and interaction, strong risk factors, and exposure to residual radiation and/or medical radiation. The risk of cancer in subjects exposed in utero is similar to that in LSS subjects who were exposed in childhood. Regarding hereditary effects of radiation exposure, no increased risk of cancers associated with parental exposure to radiation have been observed in the F1 cohort to date. In addition to biological and pathogenetic interpretations of the present results, epidemiological investigations using advanced technology should be used to further analyze these cohorts. PMID:26976124

  8. Biological profiles of Korean atomic bomb survivors in residence at Daegu and Kyungbuk, Republic of Korea.

    Science.gov (United States)

    Jhun, Hyung-Joon; Kim, Byoung-Gwon; Park, Jong-Tae; Kim, Su-Young; Koo, Bon-Min; Kim, Jin-Kook

    2008-12-01

    In 1945, many Koreans, in addition to Japanese, were killed or injured by the atomic bombs dropped on Hiroshima and Nagasaki, Japan. This study compared the biological profiles of Korean atomic bomb survivors in residence at Daegu and Kyungbuk, Republic of Korea with those of a representative sample of Koreans obtained during a similar period. We evaluated anthropometric measurements, blood pressure, blood cell counts, blood chemistry, and urinalysis of survivors (n=414) and age- and sex-matched controls (n=414) recruited from the third Korea National Health and Nutrition Examination Survey conducted in 2005. Univariate analyses revealed significantly higher systolic blood pressure, white blood cell count, and serum total cholesterol, triglycerides, high-density lipoprotein-cholesterol, and aspartate aminotransferase levels (pbomb survivors were adversely affected by radiation exposure. PMID:19119455

  9. Frequency of marriage and live birth among survivors prenatally exposed to the atomic bomb

    International Nuclear Information System (INIS)

    Frequency of marriage and birth as of January 1973 was determined for persons exposed in utero to the atomic bombs in 1945 and for controls. The marriage rate was lower in persons heavily exposed in utero than in the non-exposed or lightly exposed. This difference is attributed partly to the lesser marriageability of persons with mental retardation who are significantly more numerous among the heavily exposed, and partly to unmeasured variables, possibly including social discrimination against survivors of the atomic bomb. No consistent relation was observed between radiation exposure and three reproductive indices: childless marriages, number of births, and interval between marriage and first birth

  10. Autoantibodies and immunoglobulins among atomic-bomb survivors

    International Nuclear Information System (INIS)

    The purpose of this study was to determine if exposure to atomic-bomb radiation affects immune responsiveness, such as the occurrence of autoantibodies and levels of immunoglobulins. Rheumatoid factor, antinuclear antibody, antithyroglobulin antibody, anti-thyroid-microsomal antibody, and immunoglobulin levels (IgG, IgM, IgA, and IgE) were measured among 2061 Adult Health Study participants in Hiroshima and Nagasaki from December 1987 to November 1989. The prevalence and titers of rheumatoid factor increased in a statistically significant manner with increasing radiation dose. No radiation effect was found on the prevalence of antinuclear antibody, antithyroglobulin antibody, and anti-thyroid-microsomal antibody. A statistically significant relationship was also found between radiation exposure and the IgA level in females and the IgM levels in both sexes-both levels increased as radiation dose increased. However, the effects of radiation exposure were not large and accounted for less than 10% of the total variation in each measurement. Levels of IgG and IgE were not affected by radiation exposure. (author)

  11. Cancer and non-cancer effects in Japanese atomic bomb survivors

    Energy Technology Data Exchange (ETDEWEB)

    Little, M P [Department of Epidemiology and Public Health, Imperial College, London W2 1PG (United Kingdom)], E-mail: mark.little@imperial.ac.uk

    2009-06-01

    The survivors of the atomic bombings in Hiroshima and Nagasaki are a general population of all ages and sexes and, because of the wide and well characterised range of doses received, have been used by many scientific committees (International Commission on Radiological Protection (ICRP), United Nations Scientific Committee on the Effects of Atomic Radiation (UNSCEAR), Biological Effects of Ionizing Radiations (BEIR)) as the basis of population cancer risk estimates following radiation exposure. Leukaemia was the first cancer to be associated with atomic bomb radiation exposure, with preliminary indications of an excess among the survivors within the first five years after the bombings. An excess of solid cancers became apparent approximately ten years after radiation exposure. With increasing follow-up, excess risks of most cancer types have been observed, the major exceptions being chronic lymphocytic leukaemia, and pancreatic, prostate and uterine cancer. For most solid cancer sites a linear dose response is observed, although in the latest follow-up of the mortality data there is evidence (p = 0.10) for an upward curvature in the dose response for all solid cancers. The only cancer sites which exhibit (upward) curvature in the dose response are leukaemia, and non-melanoma skin and bone cancer. For leukaemia the dose response is very markedly upward curving, indeed largely describable as a pure quadratic dose response, particularly in the low dose (0-2 Sv) range. Even 55 years after the bombings over 40% of the Life Span Study cohort remain alive, so continued follow-up of this group is vital for completing our understanding of long-term radiation effects in people. In general, the relative risks per unit dose among the Japanese atomic bomb survivors are greater than those among comparable subsets in studies of medically exposed individuals. Cell sterilisation largely accounts for the discrepancy in relative risks between these two populations, although other

  12. Radiation and smoking effects on lung cancer incidence among atomic-bomb survivors

    OpenAIRE

    Furukawa, Kyoji; Preston, Dale; Lönn, Stefan; Funamoto, Sachiyo; Yonehara, Shuji; Matsuo, Takeshi; Egawa, Hiromi; Tokuoka, Shoji; Ozasa, Kotaro; Kasagi, Fumiyoshi; Kodama, Kazunori; Mabuchi, Kiyohiko

    2010-01-01

    While radiation increases the risk of lung cancer among members of the Life Span Study (LSS) cohort of atomic-bomb survivors, there are still important questions about the nature of its interaction with smoking, the predominant cause of lung cancer. Among 105,404 LSS subjects, 1,803 primary lung cancer incident cases were identified for the period 1958–1999. Individual smoking history information and the latest radiation dose estimates were utilized to investigate the joint effects of radiati...

  13. Radiation and Smoking Effects on Lung Cancer Incidence by Histological Types Among Atomic Bomb Survivors

    OpenAIRE

    Egawa, Hiromi; Furukawa, Kyoji; Preston, Dale; Funamoto, Sachiyo; Yonehara, Shuji; Matsuo, Takeshi; Tokuoka, Shoji; Suyama, Akihiko; Ozasa, Kotaro; Kodama, Kazunori; Mabuchi, Kiyohiko

    2012-01-01

    While the risk of lung cancer associated separately with smoking and radiation exposure has been widely reported, it is not clear how smoking and radiation together contribute to the risk of specific lung cancer histological types. With individual smoking histories and radiation dose estimates, we characterized the joint effects of radiation and smoking on type-specific lung cancer rates among the Life Span Study cohort of Japanese atomic bomb survivors. Among 105,404 cohort...

  14. Analysis of Cancer Mortality among Atomic Bomb Survivors in Hiroshima Prefecture, 1968-1997

    OpenAIRE

    Zhunussova, Tamara; Matsuura, Masaaki; Hayakawa, Norihiko

    2003-01-01

    The Research Institute for Radiation Biology and Medicine has a cohort of atomic bomb survivors, residents of Hiroshima Prefecture, followed up since 1968. An epidemiological project on cancer mortality has been extended by the 5 years from 1992 to 1997. In this paper we aim to evaluate the relative risk pattern of specific cancers by radiation dose over time and during this recent 5 years. We obtained the late effects and temporary changes from cancer sites on mortal ity such as leukemia, al...

  15. Cancer risk at low doses of ionizing radiation: artificial neural networks inference from atomic bomb survivors

    OpenAIRE

    Sasaki, Masao S.; Tachibana, Akira; Takeda, Shunichi

    2013-01-01

    Cancer risk at low doses of ionizing radiation remains poorly defined because of ambiguity in the quantitative link to doses below 0.2 Sv in atomic bomb survivors in Hiroshima and Nagasaki arising from limitations in the statistical power and information available on overall radiation dose. To deal with these difficulties, a novel nonparametric statistics based on the ‘integrate-and-fire’ algorithm of artificial neural networks was developed and tested in cancer databases established by the R...

  16. Cancer risk at low doses of ionizing radiation: artificial neural networks inference from atomic bomb survivors.

    OpenAIRE

    Sasaki, Masao S.; Tachibana, Akira; Takeda, Shunichi

    2014-01-01

    Cancer risk at low doses of ionizing radiation remains poorly defined because of ambiguity in the quantitative link to doses below 0.2 Sv in atomic bomb survivors in Hiroshima and Nagasaki arising from limitations in the statistical power and information available on overall radiation dose. To deal with these difficulties, a novel nonparametric statistics based on the 'integrate-and-fire' algorithm of artificial neural networks was developed and tested in cancer databases established by the R...

  17. Ionizing radiation exposure and the development of soft-tissue sarcomas in atomic-bomb survivors

    OpenAIRE

    Samartzis, D; Nishi, N; Cologne, J; Funamoto, S; Hayashi, M; Kodama, K; Miles, EF; Suyama, A; Soda, M; Kasagi, F

    2013-01-01

    BACKGROUND: Very high levels of ionizing radiation exposure have been associated with the development of soft-tissue sarcoma. The effects of lower levels of ionizing radiation on sarcoma development are unknown. This study addressed the role of low to moderately high levels of ionizing radiation exposure in the development of soft-tissue sarcoma. METHODS: Based on the Life Span Study cohort of Japanese atomic-bomb survivors, 80,180 individuals were prospectively assessed for the development o...

  18. Prevalence of monoclonal gammopathy of undetermined significance in Asia: a viewpoint from nagasaki atomic bomb survivors.

    Science.gov (United States)

    Iwanaga, Masako; Tomonaga, Masao

    2014-02-01

    Exposure to ionizing radiation is a known environmental risk factor for a variety of cancers including hematological malignancies, such as leukemia, myelodysplastic syndromes, and multiple myeloma. Therefore, for Hiroshima and Nagasaki atomic bomb survivors (surviving victims who were exposed to ionizing radiation emitted from the nuclear weapons), several cancer-screening tests have been provided annually, with government support, to detect the early stage of malignancies. An M-protein screening test has been used to detect multiple myeloma at an early stage among atomic bomb survivors. In the screening process, a number of patients with monoclonal gammopathy of undetermined significance (MGUS), in addition to multiple myeloma, have been identified. In 2009 and 2011, we reported the age- and sex-specific prevalence of MGUS between 1988 and 2004 and the possible role of radiation exposure in the development of MGUS using the screening data of more than 1000 patients with MGUS among approximately 52,000 Nagasaki atomic bomb survivors. The findings included: (1) a significant lower overall prevalence (2.1%) than that observed in Caucasian or African-origin populations; (2) a significantly higher prevalence in men than in women; (3) an age-related increase in the prevalence; (4) a significantly higher prevalence in people exposed to higher radiation doses only among those exposed at age 20 years or younger; and (5) a lower frequency of immunoglobulin M MGUS in Japanese patients than in patients in Western countries. The large study of MGUS among Nagasaki atomic bomb survivors has provided important findings for the etiology of MGUS, including a possible role of radiation exposure on the cause of MGUS and an ethnicity-related difference in the characteristics of MGUS. PMID:24461807

  19. Biodosimetry: chromosome aberration in lymphocytes and electron paramagnetic resonance in tooth enamel from atomic bomb survivors

    International Nuclear Information System (INIS)

    One hundred enamel samples isolated from extracted teeth donated by atomic bomb survivors were subjected to free radical measurement by means of electron paramagnetic resonance (ESR). Results comparing ESR with the chromosome aberration frequency in lymphocytes of the tooth donors, and with the physically estimated DS86 dose suggested that ESR data correlated more closely with chromosome data than with the estimated DS86 doses, probably because DS86 may depend on erroneous memory in some cases. 9 refs, 4 figs

  20. Dose estimation for atomic bomb survivor studies: its evolution and present status.

    Science.gov (United States)

    Cullings, Harry M; Fujita, Shoichiro; Funamoto, Sachiyo; Grant, Eric J; Kerr, George D; Preston, Dale L

    2006-07-01

    In the decade after the bombings of Hiroshima and Nagasaki, several large cohorts of survivors were organized for studies of radiation health effects. The U.S. Atomic Bomb Casualty Commission (ABCC) and its U.S./Japan successor, the Radiation Effects Research Foundation (RERF), have performed continuous studies since then, with extensive efforts to collect data on survivor locations and shielding and to create systems to estimate individual doses from the bombs' neutrons and gamma rays. Several successive systems have been developed by extramural working groups and collaboratively implemented by ABCC and RERF investigators. We describe the cohorts and the history and evolution of dose estimation from early efforts through the newest system, DS02, emphasizing the technical development and use of DS02. We describe procedures and data developed at RERF to implement successive systems, including revised rosters of survivors, development of methods to calculate doses for some classes of persons not fitting criteria of the basic systems, and methods to correct for bias arising from errors in calculated doses. We summarize calculated doses and illustrate their change and elaboration through the various systems for a hypothetical example case in each city. We conclude with a description of current efforts and plans for further improvements. PMID:16808610

  1. Organ dose conversions from ESR measurements using tooth enamel of atomic bomb survivors.

    Science.gov (United States)

    Takahashi, Fumiaki; Sato, Kaoru

    2012-03-01

    Dose conversions were studied for dosimetry of atomic bomb survivors based upon electron spin resonance (ESR) measurements of tooth enamel. Previously analysed data had clarified that the tooth enamel dose could be much larger than other organ doses from a low-energy photon exposure. The radiation doses to other organs or whole-body doses, however, are assumed to be near the tooth enamel dose for photon energies which are dominant in the leakage spectrum of the Hiroshima atomic bomb assumed in DS02. In addition, the thyroid can be a candidate for a surrogate organ in cases where the tooth enamel dose is not available in organ dosimetry. This paper also suggests the application of new Japanese voxel phantoms to derive tooth enamel doses by numerical analyses. PMID:22128360

  2. Cancer risk among atomic bomb survivors. The RERF Life Span Study. Radiation Effects Research Foundation.

    Science.gov (United States)

    Shimizu, Y; Schull, W J; Kato, H

    1990-08-01

    This article summarizes the risk of cancer among the survivors of the atomic bombing of Hiroshima and Nagasaki. We focus primarily on the risk of death from cancer among individuals in the Life Span Study sample of the Radiation Effects Research Foundation from 1950 through 1985 based on recently revised dosimetry procedures. We report the risk of cancer other than leukemia among the atomic bomb survivors. We note that the number of excess deaths of radiation-induced malignant tumors other than leukemia increases with age. Survivors who were exposed in the first or second decade of life have just entered the cancer-prone age and have so far exhibited a high relative risk in association with radiation dose. Whether the elevated risk will continue or will fall with time is not yet clear, although some evidence suggests that the risk may be declining. It is important to continue long-term follow-up of this cohort to document the changes with time since exposure and to provide direct rather than projected risks over the lifetime of an exposed individual. PMID:2366300

  3. Ophthalmologic survey of atomic bomb survivors in Japan, 1949. Atomic bomb radiation cataract case report with histopathologic study. Medical examination of Hiroshima patients with radiation cataracts

    Energy Technology Data Exchange (ETDEWEB)

    Cogan, D.G.; Martin, S.F.; Kimura, S.J.; Ikui, Hiroshi; Fillmore, P.G.

    1959-01-01

    This document contains 3 reports dealing with the delayed effects of radiation on the eyes of survivors of the atomic explosions in Hiroshima and Nagasaki. In the first study, 1000 persons who were listed as having been in the open and within two kilometers of the hypocenter at the time of the explosion were selected at random from the census files of the Atomic Bomb Casualty Commission for study. In addition, 231 others, comprising the total available number of surviving persons listed at present in the census files as having been within one kilometer of the hypocenter, were examined, as were several hundred others who were contacted through newspaper publicity, referrals from local ophthalmologists, or through hearsay. The survey resulted in bringing in persons having, or having had, a variety of ocular conditions. Those connected with the atomic bomb included the following diagnoses; multiple injuries of eyes and eyelids; keratoconjunctivitis from ultraviolet and ionizing radiations; thermal burn of the cornea and of the retina; retinitis proliferans; and radiation cataracts. The cataracts were the only delayed manifestations of ocular injury from the atomic bomb. The second paper is a case report of a histopathologic study of atomic bomb radiation cataract. The third paper presents the results of medical examinations of survivors having radiation induced cataracts. 32 references, 8 figures. (DMC)

  4. Evaluation of systemic markers of inflammation in atomic-bomb survivors with special reference to radiation and age effects

    OpenAIRE

    Hayashi, Tomonori; Morishita, Yukari; Khattree, Ravindra; Misumi, Munechika; Sasaki, Keiko; Hayashi, Ikue; Yoshida, Kengo; Kajimura, Junko; Kyoizumi, Seishi; Imai, Kazue; Kusunoki, Yoichiro; Nakachi, Kei

    2012-01-01

    Past exposure to atomic bomb (A-bomb) radiation has exerted various long-lasting deleterious effects on the health of survivors. Some of these effects are seen even after >60 yr. In this study, we evaluated the subclinical inflammatory status of 442 A-bomb survivors, in terms of 8 inflammation-related cytokines or markers, comprised of plasma levels of reactive oxygen species (ROS), interleukin (IL)-6, tumor necrosis factor α (TNF-α), C-reactive protein (CRP), IL-4, IL-10, and immunoglobulins...

  5. Alteration of natural killer(NK) cells in atomic bomb survivors of hiroshima

    International Nuclear Information System (INIS)

    This paper reports on the alteration of natural killer(NK) cells and their responsiveness to IL-2 observed in 125 atomic-bomb survivors. It is found no difference in the number and activity of NK cells among different dose groups with the same age ATB. But there was of difference in NK activity in different age ATB groups with same dose, especially in the g roups 25 years, the old with doses of 0.01-1 Gy (P < 0.05). This result suggests that there is an obvious late effect of ionizing radiation on activity of NK cells in children

  6. Circulating Hematopoietic Stem and Progenitor Cells in Aging Atomic Bomb Survivors.

    Science.gov (United States)

    Kyoizumi, Seishi; Kubo, Yoshiko; Misumi, Munechika; Kajimura, Junko; Yoshida, Kengo; Hayashi, Tomonori; Imai, Kazue; Ohishi, Waka; Nakachi, Kei; Young, Lauren F; Shieh, Jae-Hung; Moore, Malcolm A; van den Brink, Marcel R M; Kusunoki, Yoichiro

    2016-01-01

    It is not yet known whether hematopoietic stem and progenitor cells (HSPCs) are compromised in the aging population of atomic bomb (A-bomb) survivors after their exposure nearly 70 years ago. To address this, we evaluated age- and radiation-related changes in different subtypes of circulating HSPCs among the CD34-positive/lineage marker-negative (CD34(+)Lin(-)) cell population in 231 Hiroshima A-bomb survivors. We enumerated functional HSPC subtypes, including: cobblestone area-forming cells; long-term culture-initiating cells; erythroid burst-forming units; granulocyte and macrophage colony-forming units; and T-cell and natural killer cell progenitors using cell culture. We obtained the count of each HSPC subtype per unit volume of blood and the proportion of each HSPC subtype in CD34(+)Lin(-) cells to represent the lineage commitment trend. Multivariate analyses, using sex, age and radiation dose as variables, showed significantly decreased counts with age in the total CD34(+)Lin(-) cell population and all HSPC subtypes. As for the proportion, only T-cell progenitors decreased significantly with age, suggesting that the commitment to the T-cell lineage in HSPCs continuously declines with age throughout the lifetime. However, neither the CD34(+)Lin(-) cell population, nor HSPC subtypes showed significant radiation-induced dose-dependent changes in counts or proportions. Moreover, the correlations of the proportions among HSPC subtypes in the survivors properly revealed the hierarchy of lineage commitments. Taken together, our findings suggest that many years after exposure to radiation and with advancing age, the number and function of HSPCs in living survivors as a whole may have recovered to normal levels. PMID:26720799

  7. Lymphocyte subsets and response to PHA among atomic bomb survivors

    International Nuclear Information System (INIS)

    In an effort to elucidate the effect of radiation exposure on immune competence in man, the number of lymphocytes, lymphocyte subsets, and the percentage of phytohemagglutinin (PHA)-induced transformation of lymphocytes were determined in 66 cancer patients, 25 of whom were exposed to atomic radiation at ≤ 2,000 m from ground zero and 41 others were not exposed. The number of lymphocytes was decreased with increasing age at exposure. The percentage of OKT3-positive cells tended to be lower in exposed patients who were in their twenties at the time of exposure than the non-exposed patients. Among patients in their teens and twenties at the time of exposure, there was a tendency toward decreased percentage of OKT4-positive cells (T4) and increased percentage of OKT8-positive cells (T8). The T4/T8 ratio was reduced. Patients who were in their first decade of life at the time of exposure tended to have decreased OKIa 1-positive cells, and increased Leulla-positive cells. Patients exposed in their twenties and thirties had slightly decreased percentage of PHA-induced transformation of lymphocytes. (Namekawa, K.)

  8. Circular asymmetry of cancer mortality in Hiroshima and Nagasaki atomic bomb survivors

    International Nuclear Information System (INIS)

    Data on Hiroshima and Nagasaki atomic bomb survivors are used to investigate, for each city, possible circular asymmetry of cancer mortality around the hypocenter. Using the Cox regression method, and controlling for age at the time of the bomb, sex, follow-up year, distance from hypocenter, and type of shielding, it is found that cancer mortality in Hiroshima was significantly higher in the westerly direction from the hypocenter. Mortality from stomach cancer, leukemia, and colon cancer was higher in the westerly direction. In Nagasaki also cancer mortality, notably lung cancer mortality, was significantly higher in the westerly direction. Discussed are possible sources of the asymmetry, particularly the possibilities of asymmetry of epidemiologic variables and of radiation exposure, and indications for future work. (author)

  9. Public health nutritional studies on the atomic bomb female survivors living in Hiroshima

    International Nuclear Information System (INIS)

    The dietary life and socio-economic status of atomic bomb female survivors living in Hiroshima were investigated. The atomic bomb survivors group exposed at a long distance (LDG) was found to take a great quantity of soybean curd, miso and fruit except citrus, while the atomic bomb survivors group exposed at a short distance (SDG) was found to take a significant amount of fish paste products. SDG tends to ingest processed food and in nutrient supply rate the percentage of calcium, iron and vitamin A is low. Judging from a state of food group without a meal rate, we got the result that SDG has a few kinds of ingestion food and takes them partially in each meal. In terms of socio-economic status, the rate of living alone, supporting oneself and living an empty life is high and the rate of living with a partner is low. On the other hand, we analysed the relations of three factors on physique.physical fitness and living status, and then got the following results. (1) ''Volume capacity'', in the cases of ''be married at present'', ''have a large family'', ''ingest a lot of protein and iron'', tends to be large, while in the cases of ''have no dis ease'', ''don't go without a meal'', ''ingest a lot of carbohydrates (non-fibrous)'', and ''nutr itional balance is good'', it tends to be small. (2) ''Height'', in the case of ''socio-economical status was good before exposure to the atomic bomb'', tends to increase. (3) ''Synthetic physical fitness'', in the cases of ''health condition is good at present'', ''have no disease at present'', ''ingest a lot of vitamin A'' and ''nutritional balance is good'', tends to be superior; in the cases of ''food cost is high'' and ''ingest a lot of carbohydrates (non-fibrous)'', it tends to be low. The significant difference was observed in ''synthetic physical fitness'' between the two age groups of 50-59 years and beyond 70 years. (author)

  10. Listeria monocytogenes meningitis in an atomic bomb survivor receiving corticosteroid therapy for aplastic anemia

    International Nuclear Information System (INIS)

    We report a case of successfully treated Listeria monocytogenes (Lm) meningitis in a atomic bomb survivor receiving steroid therapy for aplastic anemia. The patient was a 62-year-old woman and the past medical history included hypothyroidism due to radioiodide therapy for Basedow disease, breast cancer, aplastic anemia, steroid-induced diabetes mellitus, and pulmonary tuberculosis. At the time of onset, she was receiving corticosteroid, anabolic steroid, an H2-blocker (famotidine), and other medication. Since she developed symptoms of meningitis when she visited our hospital for regular medical check-up for aplastic anemia, she was hospitalized and given antibiotic therapy, including ABPC, without delay. With this effective antibiotic therapy and successful management of the co-existing medical conditions, she was cured except for being a little euphoric. Lm meningitis is known to occur in aged and immunocompromised patients. Since most of the atomic bomb survivors are now aged and the prevalence of malignancy, diabetes mellitus, and other diseases which cause immunodeficiency have been rising year by year, Lm meningitis is one of the emergency neurologic conditions whose diagnosis should not be delayed in this population. (author)

  11. Listeria monocytogenes meningitis in an atomic bomb survivor receiving corticosteroid therapy for aplastic anemia

    Energy Technology Data Exchange (ETDEWEB)

    Fujihara, Kazuo; Shida, Norihiko; Ohta, Michiya [Hiroshima Atomic Bomb Hospital (Japan)

    1995-12-01

    We report a case of successfully treated Listeria monocytogenes (Lm) meningitis in a atomic bomb survivor receiving steroid therapy for aplastic anemia. The patient was a 62-year-old woman and the past medical history included hypothyroidism due to radioiodide therapy for Basedow disease, breast cancer, aplastic anemia, steroid-induced diabetes mellitus, and pulmonary tuberculosis. At the time of onset, she was receiving corticosteroid, anabolic steroid, an H{sub 2}-blocker (famotidine), and other medication. Since she developed symptoms of meningitis when she visited our hospital for regular medical check-up for aplastic anemia, she was hospitalized and given antibiotic therapy, including ABPC, without delay. With this effective antibiotic therapy and successful management of the co-existing medical conditions, she was cured except for being a little euphoric. Lm meningitis is known to occur in aged and immunocompromised patients. Since most of the atomic bomb survivors are now aged and the prevalence of malignancy, diabetes mellitus, and other diseases which cause immunodeficiency have been rising year by year, Lm meningitis is one of the emergency neurologic conditions whose diagnosis should not be delayed in this population. (author).

  12. Genetic effects of radiation in atomic-bomb survivors and their children: past, present and future.

    Science.gov (United States)

    Nakamura, Nori

    2006-01-01

    Genetic studies in the offspring of atomic bomb survivors have been conducted since 1948 at the Atomic Bomb Casualty Commission and its successor, the Radiation Effects Research Foundation, in Hiroshima and Nagasaki. Past studies include analysis of birth defects (untoward pregnancy outcome; namely, malformation, stillbirth, and perinatal death), chromosome aberrations, alterations of plasma and erythrocyte proteins as well as epidemiologic study on mortality (any cause) and cancer incidence (the latter study is still ongoing). There is, thus far, no indication of genetic effects in the offspring of survivors. Recently, the development of molecular biological techniques and human genome sequence databases made it possible to analyze DNA from parents and their offspring (trio-analysis). In addition, a clinical program is underway to establish the frequency of adult-onset multi-factorial diseases (diabetes mellitus, high blood pressure, and cardiovascular disease etc) in the offspring. The complementary kinds of data that will emerge from this three-pronged approach (clinical, epidemiologic, and molecular aspects) promise to shed light on health effects in the offspring of radiation-exposed people. PMID:17019054

  13. Public health nutritional studies on the atomic bomb female survivors living in Hiroshima

    International Nuclear Information System (INIS)

    The atomic bomb survivors group exposed at a long distance (LDG) was found to take a great quantity of soybean curd, miso and fruit except citrus, while the atomic bomb survivors group exposed at a short distance (SDG) was found to take a significant amount of fish paste product. SDG tends to ingest processed food and in nutrient supply rate the percentage of calcium, iron and vitamin A is low. Judging from a state of food group without a meal rate, we got the result that SDG has a few kinds of ingestion food and takes them partially in each meal. In terms of socio-economic status, the rate of living alone, supporting oneself and living an empty life is high and the rate of living with a partner is low. On the other hand, we analysed the relations of three factors on physique-physical fitness and living status, and then got the following results. (1) ''Volume capacity'', in the cases of ''be married at present'', ''have a large family'', ''ingest a lot of protein and iron'', tends to be large, while in the cases of ''have no disease'', ''don't go without a meal'', ''ingest a lot of carbohydrates (non-fibrous)'', and ''nutritional balance is good'', it tends to be small. (2) ''Height'', in the case of ''socio-economical status was good before exposure to the atomic bomb'', tends to increase. (3) ''Synthetic physical fitness'', in the cases of ''health condition is good at present'', ''have no disease at present'', ''ingest a lot of vitamin A'' and ''nutritional balance is good'', tends to be superior; in the cases of ''food cost is high'' and ''ingest a lot of carbohydrates (non-fibrous)'', it tends to be low. The significant difference was observed in ''synthetic physical fitness'' between the two age groups of 50-59 years and beyond 70 years. (J.P.N.)

  14. Mortality study of atomic-bomb survivors: implications for assessment of radiation accidents.

    Science.gov (United States)

    Shimizu, Y; Mabuchi, K; Preston, D L; Shigematsu, I

    1996-01-01

    To determine the possible late effects of atomic-bomb radiation, the Life Span Study (LSS) cohort of about 120,000 individuals, including 93,000 atomic bomb survivors and 27,000 non-exposed controls, was established by the Radiation Effects Research Foundation (RERF). Mortality in this cohort has been under study since 1950. Deaths are routinely identified through the family registry system and ascertainment is virtually complete. Cancer incidence data for the LSS cohort are also available from the Hiroshima and Nagasaki population-based tumour registry established in 1958. The central finding of the LSS is an increase in cancer risk. Besides the well-known increase in leukaemia, increases in solid cancer such as cancers of the lung, breast, stomach and thyroid have also been demonstrated. Radiation-induced leukaemia occurred 2 to 3 years after exposure, reached its peak within 6 to 8 years after the bombing, and has since declined steadily. However, this has not been true of solid cancer. Radiation-induced solid cancer begins to appear at later ages than such cancer is normally prone to develop, and continues to increase proportionally with the increase in mortality or incidence in the control group as it ages. Survivors who were exposed in the first or second decade of life have just entered the cancer-prone age and have so far exhibited a high relative risk in association with radiation dose. Whether the elevated risk will continue or will fail with time is not yet clear. It is important to continue long-term follow-up of this cohort to document the changes with time since exposure. Beyond cancer risk, increased risk of non-cancer mortality is also suggested, although it is not conclusive. PMID:8896256

  15. Micronuclei and Chromosome Aberrations Found 1n Bone Marrow Cells and Lymphocytes from Thorotrast Patients and Atomic Bomb Survivors

    OpenAIRE

    Tanaka, Kimio; Izumi, Takaki; Ohkita, Takeshi; Kamada, Nanao

    1984-01-01

    As two cytogenetic parameters of radiation exposure, the frequency of micronucleus in erythroblasts, lymphocytes and red cells (Howell-Jolly body) as well as chromosome aberrations in bone marrow cells and in lymphocytes were studied in 24 thorotrast patients and in 32 atomic bomb (A-bomb) survivors who were exposed within one kilometer from the Hiroshima hypocenter. The incidence of both micronucleus and chromosome aberrations in these two exposed groups were significantly higher than that i...

  16. Findings of a recent ORNL review of dosimery for the Japanese atomic-bomb survivors

    International Nuclear Information System (INIS)

    More detail than previously available on the leakage spectra of neutrons from the Nagasaki and Hiroshima weapons was provided by calculations made at the Los Alamos National Laboratory in 1976. Several neutron-transport calculations using these data predicted significantly less neutron exposure in Hiroshima than the current radiation-exposure estimates for survivors designated as T65D (or Tentative 1965 Doses). The difference was extremely important since recent studies using the T65D estimates have predicted a very large leukemia risk for neutrons at low exposure levels in Hiroshima. Some findings are that the neutron exposures in Hiroshima were probably less than the T65D estimates by factors varying from about four at a ground distance of 1000 m to eight at 2000 m, and the gamma-ray exposures were greater than the T65D estimates starting at about 1000 m and were probably larger by a factor of about three at 2000 m. In Nagasaki, the situation was reversed with respect to gamma rays, and the T65D estimates were higher, but the differences were small (i.e., about 20% at 1000 m and 30% at 2000 m). As a result, it now appears that leukemia and other late effects at lower exposure levels in Hiroshima were due largely to gamma rays rather than neutrons. This may not be true at higher exposure levels in Hiroshima, however. Any reanalysis of data on late effects among the atomic-bomb survivors should be regarded as highly speculative until some other important issues have been investigated in more detail. These issues include the anisotropy in neutron leakage from the Hiroshima weapon, the energy yield of the Hiroshima weapon, the shielding factors for houses, and the organ-dose factors for the atomic-bomb survivors

  17. (41)Ca in tooth enamel. Part I: a biological signature of neutron exposure in atomic bomb survivors.

    Science.gov (United States)

    Wallner, A; Rühm, W; Rugel, G; Nakamura, N; Arazi, A; Faestermann, T; Knie, K; Maier, H J; Korschinek, G

    2010-08-01

    The detection of (41)Ca atoms in tooth enamel using accelerator mass spectrometry is suggested as a method capable of reconstructing thermal neutron exposures from atomic bomb survivors in Hiroshima and Nagasaki. In general, (41)Ca atoms are produced via thermal neutron capture by stable (40)Ca. Thus any (41)Ca atoms present in the tooth enamel of the survivors would be due to neutron exposure from both natural sources and radiation from the bomb. Tooth samples from five survivors in a control group with negligible neutron exposure were used to investigate the natural (41)Ca content in tooth enamel, and 16 tooth samples from 13 survivors were used to estimate bomb-related neutron exposure. The results showed that the mean (41)Ca/Ca isotope ratio was (0.17 +/- 0.05) x 10(-14) in the control samples and increased to 2 x 10(-14) for survivors who were proximally exposed to the bomb. The (41)Ca/Ca ratios showed an inverse correlation with distance from the hypocenter at the time of the bombing, similar to values that have been derived from theoretical free-in-air thermal-neutron transport calculations. Given that gamma-ray doses were determined earlier for the same tooth samples by means of electron spin resonance (ESR, or electron paramagnetic resonance, EPR), these results can serve to validate neutron exposures that were calculated individually for the survivors but that had to incorporate a number of assumptions (e.g. shielding conditions for the survivors). PMID:20681780

  18. Multiple myeloma among atomic bomb survivors, Hiroshima and Nagasaki, 1950 - 76

    International Nuclear Information System (INIS)

    The relationship between atomic bomb exposure and the occurrence of multiple myeloma has been evaluated in a fixed cohort of approximately 100,000 A-bomb survivors and nonexposed controls during the period from October 1950 to December 1976. Analysis of these data revealed the standardized relative risk adjusted for city, sex, and age at the time of the bombs (ATB) to be significantly greater in the group of individuals who received 100 rad or more of radiation than in their controls. An excess risk became apparent in the high dose group about 20 years after exposure. The excess risk of multiple myeloma in those persons aged 20 - 59 ATB is estimated to be approximately 0.24 per million person-years per rad (PYR) in kerma dose and approximately 0.48 per million PYR in bone marrow dose. The interval between radiation exposure and the occurrence of an excess risk for multiple myeloma in the high dose population is considerably longer than that for leukemia. The cases of multiple myeloma observed in the high dose group showed no unusual clinical features. (author)

  19. Radiation-related risks of non-cancer outcomes in the atomic bomb survivors.

    Science.gov (United States)

    Ozasa, K; Takahashi, I; Grant, E J

    2016-06-01

    Risks of non-cancer outcomes after exposure to atomic bomb (A-bomb) radiation have been evaluated among the Life Span Study (LSS) cohort and its subcohort, the Adult Health Study (AHS). Information regarding non-cancer outcomes in the LSS is obtained from death certificates. In the AHS, members undergo clinical examinations biennially to determine their health status. Many AHS studies have been limited to participants attending the clinic over a limited period, and therefore have varying degrees of inferential utility; as such, care is required for comparison with the LSS results. Disease structure of non-cancer diseases in Japan has changed over the long follow-up period since the end of World War II. The health status of the A-bomb survivors may be associated with the hardships of living in a devastated city and impoverished country following the prolonged war effort, in addition to the direct effects of radiation exposure. Radiation-related risk of cardiovascular disease may have increased due to radiation-related increased risk of hypertension and other secondary associations, and the risk of atherosclerotic disorders has also been reported recently. These results should be interpreted with caution because of changes in disease definitions over the follow-up period. The radiation-related risk of non-cancer respiratory diseases also appears to have increased over the follow-up period, but the shapes of the dose-response curves have shown little consistency. PMID:26956675

  20. The delayed effects of radiation exposure among atomic bomb survivors, Hiroshima and Nagasaki, 1945-79

    International Nuclear Information System (INIS)

    The most important radiation-induced late medical effect in the atomic bomb survivors of Hiroshima and Nagasaki has been the increased occurrence of certain neoplasms, specifically, leukemia and cancers of the thyroid, lung, and breast. Other definite radiation-related effects include an increase in posterior lenticular opacities, chromosome aberrations in peripheral blood lymphocytes, and some abnormalities of growth and development following irradiation while in utero or during childhood. Moderate to fairly strong associations between A-bomb exposure and the increased occurrence of stomach cancer, multiple myeloma, and several other types of cancer have been observed. Radiation relationships also are suggestive for alterations of certain aspects of immune mechanisms and the increased occurrence of myelofibrosis. No increase in genetic effects has been demonstrated in the children born of exposed parents, and studies to data have been negative for evidence of increased infertility, accelerated aging, or increased mortality from diseases other than cancer. In general, the radiation dose-response relationships for most positive effects have been higher in Hiroshima than in Nagasaki, and the shape of the dose-response curves for certain effects is different in the two cities. These differences may be related to differences in the quality of the radiation from the two A-bombs. For several radiation-related effects the latent period following exposure is shorter and the incidence rate is higher in personse exposed when young as compared to exposure later in life. (author)

  1. Report on the results of the fourteenth medical examination of atomic bomb survivors resident in North America

    International Nuclear Information System (INIS)

    The fourteenth medical examination of atomic-bomb (A-bomb) survivors resident in North America was carried out from June 18th through July 2nd and from July 24th through August 6th, 2003, in the cities of Los Angeles, San Francisco, Seattle, and Honolulu. The total number of those who underwent the fourteenth medical examination was 453, 65 of whom were second-generation A-bomb survivors. As the survivors in North America are advancing in age, the average age of the examinee was 71.6 years. The examination items included an interview, clinical and physical examinations, electrocardiography (E.C.G.), and blood, urine, and stool tests. The review of the medical history showed that hypertension was the most frequent in the survivors examined, with the prevalence of 45.4%. Previous history of malignant tumors was observed in 15.7% of the survivors examined, with major sites being the mammary gland, uterine, colon, and prostate. As a result of the blood test, 14.9% of the survivors examined were diagnosed as diabetic, and hypercholesterolemia was found in 28.4% of the survivors examined. Latent hypothyroidism was found in 21.2% of the survivors examined. No disease or examination finding showed a clear relation with exposure status. A report providing the results of the medical examination and necessity of undergoing closer examination and receiving medical treatment, if any, was mailed to each examinee. (author)

  2. Survival Analyses of Atomic Bomb Survivors in Hiroshima Prefecture, Japan, 1968-1982. : Cancer Mortality Risk among Early Entrants

    OpenAIRE

    Matsuura, Masaaki; Hayakawa, Norihiko; Shimokata, Hiroshi

    1995-01-01

    We examined the mortality risk due to all causes of death and due to malignant neoplasms during 1968-82 among 204,209 atomic bomb survivors, including 49,215 early entrants. We used data compiled by the Research Institute for Radiation Biology and Medicine at Hiroshima University, which conducts mortality surveillance of these survivors in Hiroshima Prefecture, Japan. The purposes of this study were to investigate whether there was any relationship between exposure status and mortality risk a...

  3. Atomic Bomb Irradiation-induced Leukemias Revisited : Summary Data of 50 Years-Long Term Follow Up Study on Survivors

    OpenAIRE

    Tomonaga, Masao; Matsuo, Tatsuki; Preston, Dalel.; Bennett, Johnm.

    1997-01-01

    Under the cooperation between Atomic Bomb Disease Institute (ABDI) of Nagasaki University School of Medicine, Institute of Nuclear Medicine of Hiroshima University and Radiation Effect Research Foundation (RERF), the Life Span Study (LSS) on 93,741 survivors (fixed cohort) and the Open City Study (OCS) on all survivors (unfixed) irrespective of whether they belonged to LSS or not, have been conducted in parallel over 45 years to ensure reliable case detection. For diagnosis and subtyping of d...

  4. Study of skin cancer incidence in Nagasaki atomic bomb survivors, 1958-85

    International Nuclear Information System (INIS)

    The effects of exposure to ionizing radiation on skin cancer incidence in a cohort of atomic bomb (A-bomb) survivors in the Nagasaki Extended Life Span Study (LSS-E85) sample have been investigated. Among 25,942 exposed survivors at risk whose DS86 dose estimates were available, 47 cases of skin cancer including malignant melanoma were confirmed in the Nagasaki Tumor Registry during the period from 1 April 1958 to 31 December 1985. The dose-response relationship of skin cancer based on an additive relative risk model showed linearity without threshold, not a linear-quadratic curve. The excess relative risk (ERR) of 2.2 per gray in the LSS-E85 sample was highly significant (95% confidence limits: 0.5 to 5.0). In addition, the ERR of 3.1 per gray in the Adult Health Study (AHS) sample was also significant (95% confidence limits: 0.6 to 20.3). When dose equivalents based on a relative biological effectiveness of neutrons of 10 were used, the ERR in the former sample decreased to 2.0 per sievert (95% confidence limits: 0.7-4.5), and the risk in the latter group also declined, to 2.7 per sievert (95% confidence limits: 0.6-17.8). The ERRs did not differ significantly between males and females in the LSS-E85 and AHS samples, but a highly significant increase was observed for the ERR of age at exposure and time trend since exposure. The ERR of skin cancer cases including and excluding 4 malignant melanoma cases for the LSS-E85 sample (there were no malignant melanoma cases in the AHS sample) showed almost the same linear dose response. This is the first report to demonstrate a highly significant dose-response relationship between A-bomb exposure and skin cancer incidence. (author)

  5. Missing doses in the life span study of Japanese atomic bomb survivors.

    Science.gov (United States)

    Richardson, David B; Wing, Steve; Cole, Stephen R

    2013-03-15

    The Life Span Study of atomic bomb survivors is an important source of risk estimates used to inform radiation protection and compensation. Interviews with survivors in the 1950s and 1960s provided information needed to estimate radiation doses for survivors proximal to ground zero. Because of a lack of interview or the complexity of shielding, doses are missing for 7,058 of the 68,119 proximal survivors. Recent analyses excluded people with missing doses, and despite the protracted collection of interview information necessary to estimate some survivors' doses, defined start of follow-up as October 1, 1950, for everyone. We describe the prevalence of missing doses and its association with mortality, distance from hypocenter, city, age, and sex. Missing doses were more common among Nagasaki residents than among Hiroshima residents (prevalence ratio = 2.05; 95% confidence interval: 1.96, 2.14), among people who were closer to ground zero than among those who were far from it, among people who were younger at enrollment than among those who were older, and among males than among females (prevalence ratio = 1.22; 95% confidence interval: 1.17, 1.28). Missing dose was associated with all-cancer and leukemia mortality, particularly during the first years of follow-up (all-cancer rate ratio = 2.16, 95% confidence interval: 1.51, 3.08; and leukemia rate ratio = 4.28, 95% confidence interval: 1.72, 10.67). Accounting for missing dose and late entry should reduce bias in estimated dose-mortality associations. PMID:23429722

  6. Leukemia incidence in the atomic bomb survivor Life Span Study, 1950 - 87

    International Nuclear Information System (INIS)

    The Radiation Effects Research Foundation (RERF) is currently preparing a series of reports on cancer incidence in the Life Span Study (LSS) cohort of atomic bomb survivors for the period from 1950 to 1987. One of these reports will present analyses of the data on the risk of hematopoietic cancers including leukemia, malignant lymphoma, and multiple myeloma. These analyses add an additional 11 years of follow-up to the previous comprehensive analysis of the LSS leukemia data. In this presentation, these data are presented and the methods being used modeling the leukemia risks are outlined. An analysis of the leukemia data pooled over subtypes will be used to illustrate these methods. It is shown that the data suggest a non-linear, concave upward dose response and that the temporal pattern of the radiation-induced excess absolute risks (EARs) depends on age-at-exposure and sex. There is no evidence of city differences in the EAR in this pooled analysis. The results suggest that the EARs for the youngest survivors were initially much higher and have declined more rapidly than those for older survivors. The same general pattern is seen both sexes, but the initial peak incidence is somewhat lower and the rate of decline less rapid for women than for men. (author)

  7. T and B cells and PHA response of peripheral lymphocytes among atomic bomb survivors

    International Nuclear Information System (INIS)

    Little is known about immune compretence in atomic bomb survivors. The following results were observed from this study. T and B cells showed no change in proportion by age or exposure dose. The percentage of T cells was slightly lower in malignant tumor patients than in the control group. However, it was significantly higher in the group with chromosomal aberrations than in the control group. Phytohemagglutinin (PHA) response of peripheral lymphocytes decreased significantly with age in the 0 rad control group and the 200+ rad exposure group, particularly so in the latter. The malignant tumor group also showed lower PHA response than the control group. The PHA response of the chromosomal aberration group was significantly depressed compared with that of the control group. (author)

  8. Invited commentary: missing doses in the life span study of Japanese atomic bomb survivors.

    Science.gov (United States)

    Ozasa, K; Grant, E J; Cullings, H M; Shore, R E

    2013-03-15

    The Life Span Study is a long-term epidemiologic cohort study of survivors of the atomic bombs dropped on Hiroshima and Nagasaki, Japan. In this issue of the Journal, Richardson et al. (Am J Epidemiol. 2013;177(6):562-568) suggest that those who died in the earliest years of follow-up were more likely to have a missing dose of radiation exposure assigned, leading to a bias in the radiation risk estimates. We show that nearly all members of the cohort had shielding information recorded before the beginning of follow-up and that much of the alleged bias that Richardson et al. describe simply reflects the geographic distribution of shielding conditions for which reliable dosimetry was impossible. PMID:23429724

  9. ESR Dosimetry for Atomic Bomb Survivors Using Shell Buttons and Tooth Enamel

    Science.gov (United States)

    Ikeya, Motoji; Miyajima, Junko; Okajima, Shunzo

    1984-09-01

    Atomic bomb radiation doses to humans at Nagasaki and Hiroshima are investigated by electron spin resonance (ESR) from shell buttons and tooth enamel voluntarily supplied by survivors. A shell button gives a dose of 2.1± 0.2 Gy with ESR signals at g=2.001 and g=1.997 while the signal at g=1.997 for the tooth enamel of the same person is 1.9± 0.5 Gy. Other teeth show doses from about 0.5 Gy to 3 Gy. An apparent shielding converted to a concrete thickness is given using the T65D calculated in 1965. Teeth extracted during dental treatment should be preserved for cumulative radiation dosimetry.

  10. Significance of genomic instability in breast cancer in atomic bomb survivors: analysis of microarray-comparative genomic hybridization

    International Nuclear Information System (INIS)

    It has been postulated that ionizing radiation induces breast cancers among atomic bomb (A-bomb) survivors. We have reported a higher incidence of HER2 and C-MYC oncogene amplification in breast cancers from A-bomb survivors. The purpose of this study was to clarify the effect of A-bomb radiation exposure on genomic instability (GIN), which is an important hallmark of carcinogenesis, in archival formalin-fixed paraffin-embedded (FFPE) tissues of breast cancer by using microarray-comparative genomic hybridization (aCGH). Tumor DNA was extracted from FFPE tissues of invasive ductal cancers from 15 survivors who were exposed at 1.5 km or less from the hypocenter and 13 calendar year-matched non-exposed patients followed by aCGH analysis using a high-density oligonucleotide microarray. The total length of copy number aberrations (CNA) was used as an indicator of GIN, and correlation with clinicopathological factors were statistically tested. The mean of the derivative log ratio spread (DLRSpread), which estimates the noise by calculating the spread of log ratio differences between consecutive probes for all chromosomes, was 0.54 (range, 0.26 to 1.05). The concordance of results between aCGH and fluorescence in situ hybridization (FISH) for HER2 gene amplification was 88%. The incidence of HER2 amplification and histological grade was significantly higher in the A-bomb survivors than control group (P = 0.04, respectively). The total length of CNA tended to be larger in the A-bomb survivors (P = 0.15). Correlation analysis of CNA and clinicopathological factors revealed that DLRSpread was negatively correlated with that significantly (P = 0.034, r = -0.40). Multivariate analysis with covariance revealed that the exposure to A-bomb was a significant (P = 0.005) independent factor which was associated with larger total length of CNA of breast cancers. Thus, archival FFPE tissues from A-bomb survivors are useful for genome-wide aCGH analysis. Our results suggested that A-bomb

  11. Significance of genomic instability in breast cancer in atomic bomb survivors: analysis of microarray-comparative genomic hybridization

    Directory of Open Access Journals (Sweden)

    Oikawa Masahiro

    2011-12-01

    Full Text Available Abstract Background It has been postulated that ionizing radiation induces breast cancers among atomic bomb (A-bomb survivors. We have reported a higher incidence of HER2 and C-MYC oncogene amplification in breast cancers from A-bomb survivors. The purpose of this study was to clarify the effect of A-bomb radiation exposure on genomic instability (GIN, which is an important hallmark of carcinogenesis, in archival formalin-fixed paraffin-embedded (FFPE tissues of breast cancer by using microarray-comparative genomic hybridization (aCGH. Methods Tumor DNA was extracted from FFPE tissues of invasive ductal cancers from 15 survivors who were exposed at 1.5 km or less from the hypocenter and 13 calendar year-matched non-exposed patients followed by aCGH analysis using a high-density oligonucleotide microarray. The total length of copy number aberrations (CNA was used as an indicator of GIN, and correlation with clinicopathological factors were statistically tested. Results The mean of the derivative log ratio spread (DLRSpread, which estimates the noise by calculating the spread of log ratio differences between consecutive probes for all chromosomes, was 0.54 (range, 0.26 to 1.05. The concordance of results between aCGH and fluorescence in situ hybridization (FISH for HER2 gene amplification was 88%. The incidence of HER2 amplification and histological grade was significantly higher in the A-bomb survivors than control group (P = 0.04, respectively. The total length of CNA tended to be larger in the A-bomb survivors (P = 0.15. Correlation analysis of CNA and clinicopathological factors revealed that DLRSpread was negatively correlated with that significantly (P = 0.034, r = -0.40. Multivariate analysis with covariance revealed that the exposure to A-bomb was a significant (P = 0.005 independent factor which was associated with larger total length of CNA of breast cancers. Conclusions Thus, archival FFPE tissues from A-bomb survivors are useful for

  12. Biological dosimetry of atomic bomb survivors exposed within 500 meters from the hypocenter and the health consequences.

    Science.gov (United States)

    Kamada, N

    1999-12-01

    Seventy-eight atomic bomb survivors were examined for biological dosimetry using chromosome abnormality. They had been exposed within 500 meters from the hypocenter in heavily shielded conditions and were found from NHK-RIRBM joint study carried out from 1966 to 1971. Estimation of the exposure doses for these survivors was made under the following steps; 1) calculation by DS86 system (physically estimated doses) in survivors who had been exposed within 1,500 meters and had precise records of exposure conditions. RBE for the neutron was defined as 10. 2) setting of exposure dose-chromosome aberration curve, and 3) observation of chromosome aberrations in the proximally exposed survivors, for whom biological doses were estimated. Estimation of the exposure doses were possible from the aberration rate of chromosome in the peripheral lymphocytes, even 25-40 years after the exposure. Of the 78 survivors, 96% were estimated to have exposed more than one Sv. Detection of transforming gene(s) of N and K RAS genes in DNAs from non-leukemic survivors was carried out as one of the biological investigations for these heavily exposed survivors. All four survivors examined showed N or K RAS gene mutation. Three of the four healthy survivors had cancer or leukemia 7-10 years after the examination. Further continuous follow-up study of these heavily exposed people will give us more information on the late effects of A-bomb radiation, which may arise in the future. PMID:10805004

  13. Multiple myeloma among atomic bomb survivors in Hiroshima and Nagasaki, 1950-76: relationship to radiation dose absorbed by marrow

    International Nuclear Information System (INIS)

    The relationship between atomic bomb exposure and the incidence of multiple myeloma has been examined in a fixed cohort of atomic bomb survivors and controls in the life-span study sample for Hiroshima and Nagasaki. From October 1950 to December 1976, 29 cases of multiple myeloma were confirmed in this sample. Our analysis shows that the standardized relative risk (RR) adjusted for city, sex, and age at the time of bombings (ATB) increased with marrow-absorbed radiation dose. The increased RR does not appear to differ between cities or sexes and is demonstrable only for those survivors whose age ATB was between 20 and 59 years. The estimated risk in these individuals is approximately 0.48 cases/million person-years/rad for bone marrow total dose. This excess risk did not become apparent in individuals receiving 50 rad or more in marrow total dose until 20 years or more after exposure

  14. Multiple myeloma among atomic bomb survivors in Hiroshima and Nagasaki, 1950-76: relationship to radiation dose absorbed by marrow

    International Nuclear Information System (INIS)

    The relationship between atomic bomb exposure and the incidence of multiple myeloma has been examined in a fixed cohort of atomic bomb survivors and controls in the life-span study sample for Hiroshima and Nagasaki. From October 1950 to December 1976, 29 cases of multiple myeloma were confirmed in this sample. Our analysis shows that the standardized relative risk (RR) adjusted for city, sex, and age at the time of bombings (ATB) increased with marrow-absorbed radiation dose. The increased RR does not appear to differ between cities or sexes and is demonstrable only for those survivors whose age ATB was between 20 and 59 years. The estimaged risk in these individuals is approximately 0.48 cases/million person-years/rad for bone marrow total dose. This excess risk did not become apparent in individuals receiving 50 rad or more in marrow total dose until 20 years or more after exposure

  15. Hepatitis virus infection and chronic liver disease among atomic-bomb survivors

    Energy Technology Data Exchange (ETDEWEB)

    Fujiwara, Saeko; Cologne, John; Akahoshi, Masazumi [Radiation Effects Research Foundation, Hiroshima (Japan); Kusumi, Shizuyo [Institute of Radiation Epidemiology, Radiation Effects Association, Tokyo (Japan); Kodama, Kazunori; Yoshizawa, Hiroshi [Hiroshima University School of Medicine, Hiroshima (Japan)

    2000-05-01

    Hepatitis C and B virus (HCV, HBV) infection plays a crucial role in the etiology of chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma, which have been reported to increase with radiation dose among the atomic bomb survivors. The purpose of this study is to investigate whether radiation exposure altered the prevalence of hepatitis virus infection or accelerated the progress toward chronic hepatitis after hepatitis virus infection. Levels of serum antibody to hepatitis C virus (anti-HCV), HBs antigen (HBsAg), and anti-HBs antibody (anti-HBs) were measured for 6,121 participants in the Adult Health Study of atomic bomb survivors in Hiroshima and Nagasaki. No relationship was found between anti-HCV prevalence and radiation dose, after adjusting for age, sex, city, history of blood transfusion, acupuncture, and family history, but prevalence of anti-HCV was significantly lower overall among the radiation-exposed people (relative prevalence 0.84, p=0.022) compared to people with estimated radiation dose 0 Gy. No significant interaction was found between any of the above mentioned risk factors and radiation dose. People with anti-HCV positive had 13 times higher prevalence of chronic liver disease than those without anti-HCV. However, the radiation dose response for chronic liver disease among anti-HCV positive survivors may be greater than that among anti-HCV negative survivors (slope ratio 20), but the difference was marginally significant (p=0.097). Prevalence of HBsAg increased with whole-body kerma. However, no trend with radiation dose was found in the anti-HBs prevalence. In the background, prevalence of chronic liver disease in people with HBsAg-positive was approximately three times higher that in those without HBsAg. No difference in slope of the dose was found among HBsAg positive and negative individuals (slope: HBsAg positive 0.91/Gy, HBsAg negative 0.11/Gy, difference p=0.66). In conclusion, no dose-response relationship was found between

  16. Longitudinal trends of total white blood cell and differential white blood cell counts of atomic bomb survivors.

    Science.gov (United States)

    Hsu, Wan-Ling; Tatsukawa, Yoshimi; Neriishi, Kazuo; Yamada, Michiko; Cologne, John; Fujiwara, Saeko

    2010-01-01

    In studying the late health effects of atomic-bomb (A-bomb) survivors, earlier findings were that white blood cell (WBC) count increased with radiation dose in cross-sectional studies. However, a persistent effect of radiation on WBC count and other risk factors has yet to be confirmed. The objectives of the present study were 1) to examine the longitudinal relationship between A-bomb radiation dose and WBC and differential WBC counts among A-bomb survivors and 2) to investigate the potential confounding risk factors (such as age at exposure and smoking status) as well as modification of the radiation dose-response. A total of 7,562 A-bomb survivors in Hiroshima and Nagasaki were included in this study from 1964-2004. A linear mixed model was applied using the repeated WBC measurements. During the study period, a secular downward trend of WBC count was observed. Radiation exposure was a significant risk factor for elevated WBC and differential WBC counts over time. A significant increase of WBC counts among survivors with high radiation dose (> 2 Gy) was detected in men exposed below the age of 20 and in women regardless of age at exposure. Effects on WBC of low dose radiation remain unclear, however. Cigarette smoking produced the most pronounced effect on WBC counts and its impact was much larger than that of radiation exposure. PMID:20543527

  17. Effect of radiation on age at menopause among atomic bomb survivors.

    Science.gov (United States)

    Sakata, Ritsu; Shimizu, Yukiko; Soda, Midori; Yamada, Michiko; Hsu, Wan-Ling; Hayashi, Mikiko; Ozasa, Kotaro

    2011-12-01

    Exposure to ionizing radiation has been thought to induce ovarian failure and premature menopause. Proximally exposed female atomic bomb survivors were reported to experience menopause immediately after the exposure more often than those who were distally exposed. However, it remains unclear whether such effects were caused by physical injury and psychological trauma or by direct effects of radiation on the ovaries. The objective of this study was to see if there are any late health effects associated with the exposure to atomic bomb radiation in terms of age at menopause in a cohort of 21,259 Life Span Study female A-bomb survivors. Excess absolute rates (EAR) of natural and artificial menopause were estimated using Poisson regression. A linear threshold model with a knot at 0.40 Gy [95% confidence interval (CI): 0.13, 0.62] was the best fit for a dose response of natural menopause (EAR at 1 Gy at age of 50 years = 19.4/1,000 person-years, 95% CI: 10.4, 30.8) and a linear threshold model with a knot at 0.22 Gy (95% CI: 0.14, 0.34) was the best fit for artificial menopause (EAR at 1 Gy at age of 50 years for females who were exposed at age of 20 years = 14.5/1,000 person-years, 95% CI: 10.2, 20.1). Effect modification by attained age indicated that EARs peaked around 50 years of age for both natural and artificial menopause. Although effect modification by age at exposure was not significant for natural menopause, the EAR for artificial menopause tended to be larger in females exposed at young ages. On the cumulative incidence curve of natural menopause, the median age at menopause was 0.3 years younger in females exposed to radiation of 1 Gy compared with unexposed females. The median age was 1 year younger for combined natural and artificial menopause in the same comparison. In conclusion, age at menopause was thought to decrease with increasing radiation dose for both natural and artificial menopause occurring at least 5 years after the exposure. PMID:21988524

  18. The incidence of leukemia, lymphoma, and multiple myeloma among atomic bomb survivors: 1950 – 2001

    Science.gov (United States)

    Hsu, Wan-Ling; Preston, Dale L.; Soda, Midori; Sugiyama, Hiromi; Funamoto, Sachiyo; Kodama, Kazunori; Kimura, Akiro; Kamada, Nanao; Dohy, Hiroo; Tomonaga, Masao; Iwanaga, Masako; Miyazaki, Yasushi; Cullings, Harry M.; Suyama, Akihiko; Ozasa, Kotaro; Shore, Roy E.; Mabuchi, Kiyohiko

    2013-01-01

    A marked increase in leukemia risks was the first and most striking late effect of radiation exposure seen among the Hiroshima and Nagasaki atomic bomb survivors. This paper presents analyses of radiation effects on leukemia, lymphoma, and multiple myeloma incidence in the Life Span Study cohort of atomic bomb survivors updated 14 years since the last comprehensive report on these malignancies. These analyses make use of tumor- and leukemia-registry-based incidence data on 113,011 cohort members with 3.6 million person-years of follow-up from late 1950 through the end of 2001. In addition to a detailed analysis of the excess risk for all leukemias other than chronic lymphocytic leukemia or adult T-cell leukemia (neither of which appear to be radiation-related), we present results for the major hematopoietic malignancy types: acute lymphoblastic leukemia, chronic lymphocytic leukemia, acute myeloid leukemia, chronic myeloid leukemia, adult T-cell leukemia, Hodgkin and non-Hodgkin lymphoma, and multiple myeloma. Poisson regression methods were used to characterize the shape of the radiation dose response relationship and, to the extent the data allowed, to investigate variation in the excess risks with sex, attained age, exposure age, and time since exposure. In contrast to the previous report that focused on describing excess absolute rates, we considered both excess absolute rate (EAR) and excess relative risk (ERR) models and found that ERR models can often provide equivalent and sometimes more parsimonious descriptions of the excess risk than EAR models. The leukemia results indicated that there was a non-linear dose response for leukemias other than chronic lymphocytic leukemia or adult T-cell leukemia, which varied markedly with time and age at exposure, with much of the evidence for this non-linearity arising from the acute myeloid leukemia risks. Although the leukemia excess risks generally declined with attained age or time since exposure, there was evidence

  19. Primary intracranial tumors among atomic bomb survivors and controls, Hiroshima and Nagasaki, 1961-75

    International Nuclear Information System (INIS)

    An analysis was made of the relationship of radiation dose to the occurrence of primary intracranial tumors among atomic bomb survivors and nonexposed controls, Hiroshima and Nagasaki, in the fixed cohort of the Life Span Study (LSS) extended sample during the period 1961-75, or 16 to 30 years after the A-bombs. Based on various medical sources, 104 cases of primary intracranial tumors were identified among approximately 99,000 LSS extended sample members who were alive as of 1 January 1961. Of these 104 cases, 45 had manifested clinical signs of brain tumors, but, 59 cases were identified incidentally at postmortem examination. The distributions of morphologic type, age, and size of tumor were quite different for those primary intracranial tumors with and without a clinical sign of brain tumor. Glioma was the most frequent type of tumor with a clinical sign and meningioma was the most frequent type without. In relation to radiation dose the incidence rate of primary intracranial tumors with a clinical sign showed a significant excess risk for males in the high dose group who received 100 rad or more after adjustment for age at the time of the bomb (ATB). The standardized relative risk is around 5 in this group. The data also suggest that the crude relative risk of glioma is greater in the high dose group for younger ages ATB. However, there is no increased risk in females. Among the 5,012 autopsy subjects in the LSS extended sample during 1961-75, there is no relationship between radiation dose and the prevalence rate of primary intracranial tumors in those identified incidentally by autopsy. The relative risk of subclinical adenoma of the pituitary gland between high dose subjects and controls was also examined for a sample of 95 sex- and age-matched pairs using Hiroshima autopsy materials for 1961-74, but no relationship to dose was observed. (author)

  20. Relationship between epidemiological factors and mortality among atomic bomb survivors, Hiroshima and Nagasaki

    International Nuclear Information System (INIS)

    In 1965, mail survey on environmental and individual factors was performed for 11,724 male a-bomb survivors, with the age of 40 to 69, selected from the group subjected to joint JNIH-ABCC investigation of life span in a-bomb survivors. During 10 years after the mail survey, 2,834 died. The aim of this mail survey was to clarify the relationship between the mortality and specific environmental, social, and economic factors. There was a relationship between high mortality and low social and economical condition for all causes of death combined, cerebral vascular diseases, all malignant neoplasms, and gastric cancer. Smoking was a significant risk factor to all causes of death combined, ischemic heart diseases, all malignant neoplasms, gastric, tracheal, bronchial, and lung cancers. The mortality due to cardiovascular diseases was significantly higher in a-bomb survivors with heavy weight. The mortality due to all causes of death combined, all malignant neoplasms, lung, and gastric cancer tended to become higher in a-bomb survivors who got married early. (Tsunoda, M.)

  1. Capillary microscopic observations on the superficial minute vessels of atomic bomb survivors, Hiroshima 1972-73

    International Nuclear Information System (INIS)

    Microscopic and photographic studies were conducted in 1972-73 at ABCC in Hiroshima on the morphology of superficial blood vessels of A-bomb survivors to determine whether the somatic effects of radiation still existed 30 years after the A-bomb. Control curves representing the relationship between age and score values assigned to morphological changes of the minute blood vessels of the fingernail fold, labial mucosa, and lingual mucosa, which could be regarded as an index of aging, were obtained. These were compared with similar curves obtained from A-bomb survivors with the aim of evaluating the effect of radiation on the aging process of these vessels. The late somatic effects of irradiation which were demonstrated 10 years after the A-bomb in a previous study (1956-57) were found to persist in the current study (1972-73) conducted 30 years after the A-bomb though not as pronounced as in the earlier study. A significant effect was observed only in the fingernail fold of those exposed to 100 rad or more under the age of 10 at the time of the bomb. A statistically significant difference was not observed for labial mucosa and lingual mucosa because the number of cases available for scoring was small, but a trend was observed for abnormalities of these two sites to be higher in frequency in the 100+ rad group under the age of 10 ATB than that of the control group. No significant difference was observed between the control and exposed with regard to radiation effect on the aging process using the relationship of score values to age as an index of aging. This is in accord with results of studies of A-bomb survivors which suggested that radiation induces life shortening attributable primarily to cancers, but not a general acceleration of the aging phenomenon. (author)

  2. CD14 and IL18 gene polymorphisms associated with colorectal cancer subsite risks among atomic bomb survivors

    OpenAIRE

    Hu, Yiqun; Yoshida, Kengo; Cologne, John B.; Maki, Mayumi; Morishita, Yukari; Sasaki, Keiko; Hayashi, Ikue; Ohishi, Waka; Hida, Ayumi; Kyoizumi, Seishi; Kusunoki, Yoichiro; Tokunaga, Katsushi; Nakachi, Kei; Hayashi, Tomonori

    2015-01-01

    Colorectal cancer (CRC) is a common malignancy worldwide, and chronic inflammation is a risk factor for CRC. In this study, we carried out a cohort study among the Japanese atomic bomb (A-bomb) survivor population to investigate any association between immune- and inflammation-related gene polymorphisms and CRC. We examined the effects of six single-nucleotide polymorphisms of CD14 and IL18 on relative risks (RRs) of CRC. Results showed that RRs of CRC, overall and by anatomic subsite, signif...

  3. Comparison of medical data of atomic-bomb survivors resident in the U. S. and Hiroshima

    Energy Technology Data Exchange (ETDEWEB)

    Ito, Chikako (Hiroshima Atomic-Bomb Survivors Health Clinic (Japan)); Matsubara, Hiroomi; Yamakido, Michio; Yamada, Hiroaki

    1982-06-01

    The third medical examination of A-bomb survivors residing in the U.S. was performed in San Francisco, Los Angeles, Seattle and Honolulu during the period 6 - 28 May 1981. The test results were studied and the actual state of the survivors in the U.S., was reviewed as explained hereunder. 1) The number of survivors actually registered with the Committee of A-bomb Survivors in the U.S. is 491 (133 males and 358 females) of whom 57.2% are U.S. citizens. Those exposed in Hiroshima accounted for 91.8%. The mean age was 53.3 +- 8.9, thus they were more than 3 years younger than their counterparts in Hiroshima. The present addresses of the survivors are distributed over 15 states, but those in California constitute 77.6% of the total, and when those residing in the states along the west coast and Hawaii are added the rate increases to 95.9%. 2) Those who underwent health examination numbered 166 (45 males and 121 females), and comparison of the U.S. survivors against the Hiroshima survivors showed there to be a difference in the following points. The prevalence of hypertension was lower among the U.S. survivors, but RBC counts and hemoglobin concentration were significantly higher. The same was observed for blood lipids with hypercholesterolemia and hypertriglyceridemia being found at a significantly higher rate in the U.S. survivors. 3) Those free of clinical abnormalities in this survey were 37.3%, and the rest required dietary guidance, follow-up observation, detailed examination of treatment. Those with diseases which are considered would make them eligible for health management allowance if in Japan, accounted for 18.7%.

  4. Malignant breast tumors among Atomic Bomb Survivors, Hirsoshima and Nagasaki, 1950 to 1974

    Energy Technology Data Exchange (ETDEWEB)

    Tokunaga, M. (Radiation Effects Research Foundation, Hiroshima, Japan); Norman, J.E. Jr.; Asano, M.; Tokuoka, S.; Ezaki, H.; Nishimori, I.; Tsuji, Y.

    1979-06-01

    From 1950 to 1974, 360 cases of malignant breast tumors were identified among the 63,000 females of the Radiation Effects Research Foundation's (Hiroshima and Nagasaki) Extended Life-Span Study sample of survivors of the 1945 atomic bombings of Hiroshima and Nagasaki; 288 of these females were residing in one of these two cities at the time of bombing (ATB). Two-thirds of all cases were classified as breast cancers on the basis of microscopic review of slides, and 108 cases received an estimated breast tissue dose of at least 10 rads. The number of cases of radiogenic breast cancer could be well estimated by a linear function of radiation dose for tissue doses below 200 rads. Excess risk estimates, based on this function, for women 10 to 19, 20 to 29, 30 to 39, and 50 years old or older ATB were 7.3, 4.2, 2.6, and 4.7 cases per million women per year per rad, respectively. Women irradiated in their forties showed no dose effect. Among all women who received at least 10 rads, those irradiated before age 20 years will have experienced the highest rates of breast cancer throughout their lifetimes. Separate excess risk estimates for Hiroshima and Nagasaki did not differ significantly, which indicates that for radiogenic breast cancer the effects of neutrons (emitted only in the Hiroshima explosion) and gamma radiation were about equal. Radiation did not reduce the latency period for the development of breast cancer, which was at least 10 years. The distribution of histologic types of cancers did not vary significantly with radiation dose. The data suggested that irradiation prior to menarche conferred a greater risk than irradiation after menarche.

  5. Cell biological study in multiple myeloma among atomic bomb survivors, 3

    International Nuclear Information System (INIS)

    To determine how quantitative changes and qualitative abnormalities of IL-6R receptor (IL-6R) is involved in proliferation promotion of myeloma cells, the expression of IL-6R and recomposition of IL-6R genes were examined in myeloma cells obtained from a total of 37 patients with multiple myeloma (MM) or plasma cell leukemia, including 6 A-bomb survivors. Among 6 A-bomb survivors, 4 had been directly exposed and the other two had entered the city after A-bombing. Binding assay performed in 10 patients revealed binding ability in all of them; the number of bound IL-6R was 31-2440/cell and Kd value was 1.2-3.7 x 10-10 M. Northern blot test revealed noticeable IL-6R mRNA expression in only one MM patient. Nor was definitive IL-6R expression observed by flow cytometry. There was no recomposition of IL-6R genes in any of 20 MM patients, including A-bomb survivors. This may deny extensively structural abnormality in the genetic area that activates IL-6R genes. Regarding the expression of IL-6R of myeloma cells, such as the number of IL-6R, Kd value, the expression of IL-6R mRNA, and the recomposition of IL-6R genes, there was no difference between the exposed and non-exposed groups. In elucidating the occurrence of M protenemia in A-bomb survivors, further studies are required concerning IL-6 and IL-6R involved in proliferation mechanism of myeloma cells. (N.K.)

  6. Liver Cancer in Atomic-bomb Survivors: Histological Characteristics and Relationships to Radiation and Hepatitis B and C Viruses

    OpenAIRE

    Fukuhara, Toshiyuki; Sharp, Gerald B.; Mizuno, Terumi; Itakura, Hideyo; Yamamoto, Masami; TOKUNAGA, Masayoshi; Tokuoka, Shoji; Cologne, John B.; Fujita, Yasuyuki; Soda, Midori; Mabuchi, Kiyohiko

    2001-01-01

    Histological features of primary liver cancer among atomic-bomb survivors and their relationship to hepatitis B (HBV) and C viral (HCV) infections are of special interest because of the increased risk of liver cancer in persons exposed to ionizing radiation and the high and increasing liver cancer rates in Japan and elsewhere. We conducted a pathology review of liver cancers occurring from 1958 to 1987 among subjects in the 120,321 member cohort of 1945 Hiroshima and Nagasaki residents. A pan...

  7. Dose–responses from multi-model inference for the non-cancer disease mortality of atomic bomb survivors

    OpenAIRE

    Schöllnberger, H.; Kaiser, J. C.; Jacob, P.; Walsh, L

    2012-01-01

    The non-cancer mortality data for cerebrovascular disease (CVD) and cardiovascular diseases from Report 13 on the atomic bomb survivors published by the Radiation Effects Research Foundation were analysed to investigate the dose–response for the influence of radiation on these detrimental health effects. Various parametric and categorical models (such as linear-no-threshold (LNT) and a number of threshold and step models) were analysed with a statistical selection protocol that rated the mode...

  8. Evaluation of systemic markers of inflammation in atomic-bomb survivors with special reference to radiation and age effects.

    Science.gov (United States)

    Hayashi, Tomonori; Morishita, Yukari; Khattree, Ravindra; Misumi, Munechika; Sasaki, Keiko; Hayashi, Ikue; Yoshida, Kengo; Kajimura, Junko; Kyoizumi, Seishi; Imai, Kazue; Kusunoki, Yoichiro; Nakachi, Kei

    2012-11-01

    Past exposure to atomic bomb (A-bomb) radiation has exerted various long-lasting deleterious effects on the health of survivors. Some of these effects are seen even after >60 yr. In this study, we evaluated the subclinical inflammatory status of 442 A-bomb survivors, in terms of 8 inflammation-related cytokines or markers, comprised of plasma levels of reactive oxygen species (ROS), interleukin (IL)-6, tumor necrosis factor α (TNF-α), C-reactive protein (CRP), IL-4, IL-10, and immunoglobulins, and erythrocyte sedimentation rate (ESR). The effects of past radiation exposure and natural aging on these markers were individually assessed and compared. Next, to assess the biologically significant relationship between inflammation and radiation exposure or aging, which was masked by the interrelationship of those cytokines/markers, we used multivariate statistical analyses and evaluated the systemic markers of inflammation as scores being calculated by linear combinations of selected cytokines and markers. Our results indicate that a linear combination of ROS, IL-6, CRP, and ESR generated a score that was the most indicative of inflammation and revealed clear dependences on radiation dose and aging that were found to be statistically significant. The results suggest that collectively, radiation exposure, in conjunction with natural aging, may enhance the persistent inflammatory status of A-bomb survivors. PMID:22872680

  9. The nonlinear relationship of radiation dose to chromosome aberrations among atomic bomb survivors, Hiroshima and Nagasaki

    International Nuclear Information System (INIS)

    The quantitative relationship of the frequency of cells with radiation-induced chromosome aberrations in peripheral leukocytes in atomic bomb survivors has been evaluated as a function of gamma and neutron doses. Three different models have been examined; each assumes a nonlinear-response to gamma rays and a linear-response to neutrons. From the standpoint of the goodness of fit of these models, the model which ''best'' fits the data of radiation-induced chromosome aberrations is the exponit model, where the frequency of aberrant cells increases exponentially with dose. It is of radiobiological interest that the goodness of fit for this model shows the frequencies of cells with any chromosome aberration or an exchange aberration to be dependent cubically on the gamma ray dose and linearly on the neutron dose. The relative biological effectiveness (RBE) of neutrons is calculated to be 129Dn sup(-2/3) (95% confidence intervals: (121 -- 137)Dn sup(-2/3)) for frequency of cells with any chromosome aberration, and 125Dn sup(-2/3) (95% confidence intervals: (117 -- 132)Dn sup(-2/3)) for the frequency of cells with an exchange aberration where Dn is the neutron dose. (author)

  10. Cancer risk at low doses of ionizing radiation: artificial neural networks inference from atomic bomb survivors.

    Science.gov (United States)

    Sasaki, Masao S; Tachibana, Akira; Takeda, Shunichi

    2014-05-01

    Cancer risk at low doses of ionizing radiation remains poorly defined because of ambiguity in the quantitative link to doses below 0.2 Sv in atomic bomb survivors in Hiroshima and Nagasaki arising from limitations in the statistical power and information available on overall radiation dose. To deal with these difficulties, a novel nonparametric statistics based on the 'integrate-and-fire' algorithm of artificial neural networks was developed and tested in cancer databases established by the Radiation Effects Research Foundation. The analysis revealed unique features at low doses that could not be accounted for by nominal exposure dose, including (i) the presence of a threshold that varied with organ, gender and age at exposure, and (ii) a small but significant bumping increase in cancer risk at low doses in Nagasaki that probably reflects internal exposure to (239)Pu. The threshold was distinct from the canonical definition of zero effect in that it was manifested as negative excess relative risk, or suppression of background cancer rates. Such a unique tissue response at low doses of radiation exposure has been implicated in the context of the molecular basis of radiation-environment interplay in favor of recently emerging experimental evidence on DNA double-strand break repair pathway choice and its epigenetic memory by histone marking. PMID:24366315

  11. Spontaneous immortalization of cultured skin fibroblasts obtained from a high-dose atomic bomb survivor

    International Nuclear Information System (INIS)

    Two immortal fibroblastic cell strains (substrains) were established by culturing healthy skin cells obtained from a high-dose atomic bomb survivor (female, age 76 years, 5.14 Gy) for more than 4 years. Designated FM-U and FM-M, the two substrains share the same marker chromosome, t(5q-;6p+), but are karyotypically different, possessing hypodiploid chromosome numbers (39-43) in the former and hypertriploid (69-76) in the latter. Thus far, the two strains have passed through 117 and 156 subcultures or more than 230 and 310 cumulative population doublings, respectively, each passage requiring 4-6 days in the former and 3-4 days in the latter. In the process of immortalization, sequential rearrangement among various chromosomes presumably due to telomeric and interstitial telomeric fusions took place following the telomere shortening, particularly in the senescence and postsenescence phase cells. Of particular interest is the fact that loss of heterozygosity (LOH) of the p53 gene was demonstrated in these immortalized cell populations. In addition, the allelic patterns of the LOH of p53 differed. Further evidence indicative of infinite proliferation was demonstrated in both strains, such as the telomere elongation and the significantly low frequency of cells possessing dicentric chromosomes

  12. Radiation risk of individual multifactorial diseases in offspring of the atomic-bomb survivors: a clinical health study.

    Science.gov (United States)

    Tatsukawa, Yoshimi; Cologne, John B; Hsu, Wan-Ling; Yamada, Michiko; Ohishi, Waka; Hida, Ayumi; Furukawa, Kyoji; Takahashi, Norio; Nakamura, Nori; Suyama, Akihiko; Ozasa, Kotaro; Akahoshi, Masazumi; Fujiwara, Saeko; Shore, Roy

    2013-06-01

    There is no convincing evidence regarding radiation-induced heritable risks of adult-onset multifactorial diseases in humans, although it is important from the standpoint of protection and management of populations exposed to radiation. The objective of the present study was to examine whether parental exposure to atomic-bomb (A-bomb) radiation led to an increased risk of common polygenic, multifactorial diseases-hypertension, hypercholesterolaemia, diabetes mellitus, angina pectoris, myocardial infarction or stroke-in the first-generation (F1) offspring of A-bomb survivors. A total of 11,951 F1 offspring of survivors in Hiroshima or Nagasaki, conceived after the bombing, underwent health examinations to assess disease prevalence. We found no evidence that paternal or maternal A-bomb radiation dose, or the sum of their doses, was associated with an increased risk of any multifactorial diseases in either male or female offspring. None of the 18 radiation dose-response slopes, adjusted for other risk factors for the diseases, was statistically significantly elevated. However, the study population is still in mid-life (mean age 48.6 years), and will express much of its multifactorial disease incidence in the future, so ongoing longitudinal follow-up will provide increasingly informative risk estimates regarding hereditary genetic effects for incidence of adult-onset multifactorial disease. PMID:23482396

  13. The cohort of the atomic bomb survivors major basis of radiation safety regulations

    CERN Document Server

    Rühm, W; Nekolla, E A

    2006-01-01

    Since 1950 about 87 000 A-bomb survivors from Hiroshima and Nagasaki have been monitored within the framework of the Life Span Study, to quantify radiation-induced late effects. In terms of incidence and mortality, a statistically significant excess was found for leukemia and solid tumors. In another major international effort, neutron and gamma radiation doses were estimated, for those survivors (Dosimetry System DS02). Both studies combined allow the deduction of risk coefficients that serve as a basis for international safety regulations. As an example, current results on all solid tumors combined suggest an excess relative risk of 0.47 per Sievert for an attained age of 70 years, for those who were exposed at an age of 30 years. After exposure to an effective dose of one Sievert the solid tumor mortality would thus be about 50% larger than that expected for a similar cohort not exposed to any ionizing radiation from the bombs.

  14. Delayed effects of low-dose radiation on cellular immunity in atomic bomb survivors residing in the United States.

    Science.gov (United States)

    Bloom, E T; Akiyama, M; Kusunoki, Y; Makinodan, T

    1987-05-01

    Several parameters of cellular immune function were assessed among persons who survived the 1945 atomic bombs in Hiroshima and Nagasaki but who now reside in the United States. The subjects in this study were exposed to various low doses (T65D) of radiation at the time of the bomb. More than half received an estimated 0 Gy (S0 group). Of those exposed to more radiation (S+ group), nearly 90% received less than 0.50 Gy (50 rad). Lymphocytes were isolated from the peripheral blood of these individuals and were assessed for the following parameters of cellular immunity: mitogenic response to phytohemagglutinin, mitogenic response to allogeneic lymphocytes, natural cell-mediated cytotoxicity (NCMC), and interferon production. In every case, the response of the S+ group was greater than that of the S0 group, although only the difference for NCMC was statistically significant. Results of studies presently being performed on A-bomb survivors residing in Hiroshima do not confirm this difference. Therefore, it is difficult to say whether the increase in natural cytotoxicity observed among the American and not the Japanese A-bomb survivors exposed to very low doses of radiation is a hormetic effect which was modulated by post-radiation environmental conditions or a result of selective migration. PMID:3570796

  15. Mutations detected in the repetitive sequences in the children of the atomic bomb survivors

    International Nuclear Information System (INIS)

    We have been examining genetic effects of radiation in the children of the atomic bomb survivors. In a pilot study, 50 exposed families with 64 children and 50 control families with 60 children were examined for trinucleotide repeat expansion mutations at 3 loci and mutations at 6 minisatellite loci. Average dose of the 51 exposed parents was 1.8 Sv. By examining 124 children of 100 families, 65 germ cells derived from exposed parents and 183 germ cells of non-exposed parents were examined. The trinucleotide repeat expansions in genes of certain human genetic diseases show remarkable variation both within the cells of a single individual and among affected members of a single family which have been interpreted as mitotic and meiotic instability. We examined the regions with triplet repeats in the FMR-1, AR and DM genes causative for fragile X syndrome, spinobulbar muscular atrophy and myotonic dystrophy. No mutations were detected in 177 regions derived from 65 germ cells of exposed parents and 443 regions from 183 germ cells of non-exposed parents. No effects on the instability of the triplet repeats in the germ cells derived from exposed or unexposed individuals were observed. In the examinations of the 6 minisatellite loci of Pc-1, λTM-18, ChdTC-15, pλg3, λMS-1, and CEB-1, we detected single mutations at each of the pλg3 and λMS-1, and 4 mutations at the CEB-1 locus which had occurred in the 65 gametes in the exposed parents. Thus, mutation rates per gamete at the pλg3, λMS-1 and CEB-1 were 1.5%, 1.5% and 6.2%. On the other hand, mutations in these 3 loci in the 183 gametes of non-exposed parents were 0, 11 and 11, that is, the mutation rates per gamete were 0%, 6.0% and 6.0%. No significant difference was observed in the mutation rate at each of the 3 loci between 2 groups of parents. These preliminary results suggest that A-bomb exposure seems not to affect the germline instability at these 3 loci. (J.P.N)

  16. Notes of problems in estimating mortality rate among atomic-bomb survivors, 3

    International Nuclear Information System (INIS)

    Annual changes in death hazard were compared in the group in which persons entered the city after the A-bomb explosion and acquired a health handbook during the period 1968-1976 (the case group) and the group in which A-bomb survivors had already acquired it as of 1960 (the control group). Mortality was analyzed by malignant diseases, cardiovascular diseases, digestive system diseases, and respiratory system diseases. Death hazard from malignant tumors was markedly high 3 to 4 years after the acquisition of the health handbook, irrespective of sex, in the case group. For cardiovascular diseases, it was high up to 8 years after the acquisition in males of the case group; however, it tended to be slightly higher in women immediately after the acquisition, and thereafter, it was not different from that in the control group. For both digestive system diseases and respiratory system diseases, death hazard tended to be higher in the case group than the control group during 8 years after the acquisition. The fact that death hazard was higher in the case group than the control group several years after the acquisition means that the acquisition of health handbook may be triggered by worse health conditions in A-bomb survivors in the case group. (N.K.)

  17. Investigation of cardio-vascular reflex in atomic bomb survivors, (2)

    International Nuclear Information System (INIS)

    Electrographic R-R interval variation was examined in a total of 915 A-bomb survivors exposed at ≤2,000 m from the hypocenter (the ≤ 2,000 m group) and a total of 1,162 A-bomb survivors exposed at >3,000 m or entered the city after the A-bombing (the >3,000 m group). Coefficient of variation (CV) for R-R interval variation on ECG tended to be decreased with advancing age in the >3,000 m group, irrespective of sex. Especially for men in this group, CV values were significantly lower for the age group of 45 to 54 years than the groups of 65 to 74 years and 75 to 84 years. Similar tendency was observed for CV values at deep breath. Decreased CV values tended to be associated with a decrease in glucose tolerance in both men and women of the >3,000 m group. In comparing the aforementioned CV values with those in the ≤2,000 m group, there was no significant difference between the groups. R-R interval variation on ECG was found independent of exposure condition, although it was influenced by sex, age, and glucose tolerance. (N.K.)

  18. Joint analysis of site-specific cancer risks for the atomic bomb survivors

    International Nuclear Information System (INIS)

    Statistical methods are presented for joint analysis of site-specific cancer risks for the atomic-bomb survivors. Previous analyses of these data, aside from those on leukemia, have been made either without regard to cancer type, or separately for types or classes of cancers. Clearly, analyses without regard to cancer type are less than satisfactory. The primary advantages of joint, rather than separate, analyses are that (1) models can be fitted with parameters common to cancer types, which can allow more-precise estimation of effects of interest, (2) significance tests can be used to compare type-specific risks, and (3) a clearer understanding may be obtained of risk-modification factors such as sex, age at exposure, and time since exposure. Joint analysis is straightforward, entailing primarily the incorporation of another factor for cancer type in the usual cross-tabulation of the data for analysis. The use of these methods is illustrated in an analysis of the three categories of cancer studied by the fifth Advisory Committee on the Biological Effects of Ionizing Radiation (BEIR V): digestive, respiratory, and other solid tumors. Based on this analysis, some criticism is made of the BEIR V-preferred models. Since the proposed methods are applicable to models for either relative or absolute risks, some comments on the use of explicit models for the absolute excess risk are also given. Although some of the gains from joint analysis are apparent from the results here, it will be important to use these methods with a more suitable choice of cancer classes and for cancer incidence data in which the diagnoses are more accurate. (author)

  19. Radiation and smoking effects on lung cancer incidence by histological types among atomic bomb survivors.

    Science.gov (United States)

    Egawa, Hiromi; Furukawa, Kyoji; Preston, Dale; Funamoto, Sachiyo; Yonehara, Shuji; Matsuo, Takeshi; Tokuoka, Shoji; Suyama, Akihiko; Ozasa, Kotaro; Kodama, Kazunori; Mabuchi, Kiyohiko

    2012-09-01

    While the risk of lung cancer associated separately with smoking and radiation exposure has been widely reported, it is not clear how smoking and radiation together contribute to the risk of specific lung cancer histological types. With individual smoking histories and radiation dose estimates, we characterized the joint effects of radiation and smoking on type-specific lung cancer rates among the Life Span Study cohort of Japanese atomic bomb survivors. Among 105,404 cohort subjects followed between 1958 and 1999, 1,803 first primary lung cancer incident cases were diagnosed and classified by histological type. Poisson regression methods were used to estimate excess relative risks under several interaction models. Adenocarcinoma (636 cases), squamous-cell carcinoma (330) and small-cell carcinoma (194) made up 90% of the cases with known histology. Both smoking and radiation exposure significantly increased the risk of each major lung cancer histological type. Smoking-associated excess relative risks were significantly larger for small-cell and squamous-cell carcinomas than for adenocarcinoma. The gender-averaged excess relative risks per 1 Gy of radiation (for never-smokers at age 70 after radiation exposure at age 30) were estimated as 1.49 (95% confidence interval 0.1-4.6) for small-cell carcinoma, 0.75 (0.3-1.3) for adenocarcinoma, and 0.27 (0-1.5) for squamous-cell carcinoma. Under a model allowing radiation effects to vary with levels of smoking, the nature of the joint effect of smoking and radiation showed a similar pattern for different histological types in which the radiation-associated excess relative risk tended to be larger for moderate smokers than for heavy smokers. However, in contrast to analyses of all lung cancers as a group, such complicated interactions did not describe the data significantly better than either simple additive or multiplicative interaction models for any of the type-specific analyses. PMID:22862780

  20. Radiation and Smoking Effects on Lung Cancer Incidence by Histological Types Among Atomic Bomb Survivors

    Science.gov (United States)

    Egawa, Hiromi; Furukawa, Kyoji; Preston, Dale; Funamoto, Sachiyo; Yonehara, Shuji; Matsuo, Takeshi; Tokuoka, Shoji; Suyama, Akihiko; Ozasa, Kotaro; Kodama, Kazunori; Mabuchi, Kiyohiko

    2014-01-01

    While the risk of lung cancer associated separately with smoking and radiation exposure has been widely reported, it is not clear how smoking and radiation together contribute to the risk of specific lung cancer histological types. With individual smoking histories and radiation dose estimates, we characterized the joint effects of radiation and smoking on type-specific lung cancer rates among the Life Span Study cohort of Japanese atomic bomb survivors. Among 105,404 cohort subjects followed between 1958 and 1999, 1,803 first primary lung cancer incident cases were diagnosed and classified by histological type. Poisson regression methods were used to estimate excess relative risks under several interaction models. Adenocarcinoma (636 cases), squamous-cell carcinoma (330) and small-cell carcinoma (194) made up 90% of the cases with known histology. Both smoking and radiation exposure significantly increased the risk of each major lung cancer histological type. Smoking-associated excess relative risks were significantly larger for small-cell and squamous-cell carcinomas than for adenocarcinoma. The gender-averaged excess relative risks per 1 Gy of radiation (for never-smokers at age 70 after radiation exposure at age 30) were estimated as 1.49 (95% confidence interval 0.1–4.6) for small-cell carcinoma, 0.75 (0.3–1.3) for adenocarcinoma, and 0.27 (0–1.5) for squamous-cell carcinoma. Under a model allowing radiation effects to vary with levels of smoking, the nature of the joint effect of smoking and radiation showed a similar pattern for different histological types in which the radiation-associated excess relative risk tended to be larger for moderate smokers than for heavy smokers. However, in contrast to analyses of all lung cancers as a group, such complicated interactions did not describe the data significantly better than either simple additive or multiplicative interaction models for any of the type-specific analyses. PMID:22862780

  1. Cell biological study in multiple myeloma among atomic bomb survivors, 1

    International Nuclear Information System (INIS)

    The aim of this study was to determine whether IL-6 production from myeloma cells is influenced by A-bombing. Subjects were 20 patients with multiple myeloma, consisting of 9 A-bomb exposed patients and 11 non-exposed patients. According to disease types, 8 had IgG and one had BJ in the exposed group; 4 had IgG, 4 had IgA, and 3 had BJ in the non-exposed group. In the exposed group, two were clinically staged as Stage I, 3 as Stage II, and 4 as Stage III; and one was staged as Stage I, 4 as Stage II, and 6 as Stage III in the non-exposed group. In both exposed and non-exposed groups, IL-6 production was observed in myeloma cells. There was no definitive difference in IL-6 production from myeloma cells between the groups. These findings suggest that IL-6 production is influenced by other factors than A-bombing. There is much to be done before promotion mechanism of multiple myeloma may be elucidated among A-bomb survivors. (N.K.)

  2. [The present state of atomic bomb survivors, with special reference to biological late-effects of radiation].

    Science.gov (United States)

    Kamada, Nanao

    2004-03-01

    Atomic bombs were dropped on Hiroshima and Nagasaki in August 1945. Within a few months, the bomb blast, heat and radiation emitted by the atomic explosions led to approximately 114,000 fatalities in Hiroshima and about 70,000 in Nagasaki. The radiation in particular continued to exert effects on the human body over a long period of time, resulting in the development of tumors and functional abnormalities in various organs. This paper briefly outlines the diseases caused by radiation as well as the biological late-effects on the survivors without any specific diseases, and stresses the necessity of our enthusiastic opposition to the use of any kind of nuclear weapons. PMID:15137319

  3. Present status and self-reported diseases of the Korean atomic bomb survivors: a mail questionnaire survey.

    Science.gov (United States)

    Jhun, Hyung-Joon; Ju, Young-Su; Kim, Jung-Bum; Kim, Jin-Kook

    2005-01-01

    Many Koreans were forced to move to Japan while Korea was occupied by Japan. Consequently, when the atomic bombs were dropped on Hiroshima and Nagasaki an estimated 40,000 Koreans died and 30,000 survived. In 2004, 2,235 Koreans were registered as A-bomb survivors in South Korea. A mail questionnaire survey to evaluate the present status and self-reported diseases of the Korean survivors was conducted. In total, 1,256 questionnaires were returned and analysed. The most frequent chronic diseases reported by Korean survivors were hypertension (40.1 per cent), peptic ulcer disease (25.7 per cent), anaemia (23.3 per cent) and cataracts (23.1 per cent). The most frequent malignant diseases were stomach cancer (1.9 per cent), colon cancer (0.5 per cent) and leukaemia/multiple myeloma (0.4 per cent). This study suggests that further investigations are needed into the health concerns of the survivors and into health protection measures. PMID:16180735

  4. Report on results of third medical examination of Atomic Bomb Survivors residing in the U. S

    Energy Technology Data Exchange (ETDEWEB)

    Matsubara, H. (Hiroshima Prefectural Medical Association (Japan)); Yamakido, M.; Ito, C.; Yamada, H.

    1982-01-01

    The number of survivors actually registered with the Committee of A-bomb survivors in the U.S. is 491 (133 males and 358 females) of whom 57.3% are U.S. citizens. Those exposed in Hiroshima accounted for 91.8%. The mean age was 53.3 +- 8.9, thus they were more than 3 years younger than their counterparts in Hiroshima. Responses to the Health Survey Questionnaires numbered 255, and those with symptoms which appeared to be related to diseases were found at a high rate among the early entrants, but as the number of those receiving examination in this group was few, it is considered that many of those in poor health had come in for the examination. No association could be demonstrated between psychological complaints and exposure status. Those who underwent health examination numbered 166 (45 males and 121 females), and comparison of the U.S. survivors against the Hiroshima survivors showed there to be a difference in the following points. The prevalence of hypertension was lower among the U.S. survivors, but RBC counts and hemoglobin values were significantly higher. The same was observed for blood lipids with hypercholesterolemia and hypertriglyceridemia being found at a significantly higher rate in the U.S. survivors, the cause being considered to be the larger intake of animal fat and sugar by those of Japanese ancestry than the indigenous Japanese. Those free of clinical abnormalities in this survey were 37.3%, and the rest required dietary guidance, follow-up observation, detailed examination or treatment. Those with diseases which are considered would make them eligible for health management allowance if in Japan, accounted for 18.7%.

  5. Radiation risks in lung cancer screening programs: a comparison with nuclear industry workers and atomic bomb survivors.

    Science.gov (United States)

    McCunney, Robert J; Li, Jessica

    2014-03-01

    The National Lung Cancer Screening Trial (NLST) demonstrated that screening with low-dose CT (LDCT) scan reduced lung cancer and overall mortality by 20% and 7%, respectively. The LDCT scanning involves an approximate 2-mSv dose, whereas full-chest CT scanning, the major diagnostic study used to follow up nodules, may involve a dose of 8 mSv. Radiation associated with CT scanning and other diagnostic studies to follow up nodules may present an independent risk of lung cancer. On the basis of the NLST, we estimated the incidence and prevalence of nodules detected in screening programs. We followed the Fleischner guidelines for follow-up of nodules to assess cumulative radiation exposure over 20- and 30-year periods. We then evaluated nuclear worker cohort studies and atomic bomb survivor studies to assess the risk of lung cancer from radiation associated with long-term lung cancer screening programs. The findings indicate that a 55-year-old lung screening participant may experience a cumulative radiation exposure of up to 280 mSv over a 20-year period and 420 mSv over 30 years. These exposures exceed those of nuclear workers and atomic bomb survivors. This assessment suggests that long-term (20-30 years) LDCT screening programs are associated with nontrivial cumulative radiation doses. Current lung cancer screening protocols, if conducted over 20- to 30-year periods, can independently increase the risk of lung cancer beyond cigarette smoking as a result of cumulative radiation exposure. Radiation exposures from LDCT screening and follow-up diagnostic procedures exceed lifetime radiation exposures among nuclear power workers and atomic bomb survivors.

  6. Radiation risks in lung cancer screening programs: a comparison with nuclear industry workers and atomic bomb survivors.

    Science.gov (United States)

    McCunney, Robert J; Li, Jessica

    2014-03-01

    The National Lung Cancer Screening Trial (NLST) demonstrated that screening with low-dose CT (LDCT) scan reduced lung cancer and overall mortality by 20% and 7%, respectively. The LDCT scanning involves an approximate 2-mSv dose, whereas full-chest CT scanning, the major diagnostic study used to follow up nodules, may involve a dose of 8 mSv. Radiation associated with CT scanning and other diagnostic studies to follow up nodules may present an independent risk of lung cancer. On the basis of the NLST, we estimated the incidence and prevalence of nodules detected in screening programs. We followed the Fleischner guidelines for follow-up of nodules to assess cumulative radiation exposure over 20- and 30-year periods. We then evaluated nuclear worker cohort studies and atomic bomb survivor studies to assess the risk of lung cancer from radiation associated with long-term lung cancer screening programs. The findings indicate that a 55-year-old lung screening participant may experience a cumulative radiation exposure of up to 280 mSv over a 20-year period and 420 mSv over 30 years. These exposures exceed those of nuclear workers and atomic bomb survivors. This assessment suggests that long-term (20-30 years) LDCT screening programs are associated with nontrivial cumulative radiation doses. Current lung cancer screening protocols, if conducted over 20- to 30-year periods, can independently increase the risk of lung cancer beyond cigarette smoking as a result of cumulative radiation exposure. Radiation exposures from LDCT screening and follow-up diagnostic procedures exceed lifetime radiation exposures among nuclear power workers and atomic bomb survivors. PMID:24590022

  7. Declining Trends in Blood Pressure Levels and Prevalence of Hypertention in Atomic Bomb Survivors in Nagasaki, Japan, 1971-1991

    OpenAIRE

    Honda, Y; Nakashima, H; Katayama, T

    1994-01-01

    The annual trends in blood pressure levels and prevalence of hypertension classified by JNC-5 were investigated. This survey was conducted retrospectively in a large cohort of Nagasaki atomic bomb survivors (78, 323 persons in 1971) over 20 years. In the age-sex specific groups from the 30's to the 90's, the levels of mean SBP decreased in the latter 10 years compared to the former 10 years except in males in the 30's and the mean DBP decreased except in both sexes in the 30's. The annual tre...

  8. Long-term trend of thyroid cancer risk among Japanese atomic-bomb survivors: 60 years after exposure.

    Science.gov (United States)

    Furukawa, Kyoji; Preston, Dale; Funamoto, Sachiyo; Yonehara, Shuji; Ito, Masahiro; Tokuoka, Shoji; Sugiyama, Hiromi; Soda, Midori; Ozasa, Kotaro; Mabuchi, Kiyohiko

    2013-03-01

    Thyroid cancer risk following exposure to ionizing radiation in childhood and adolescence is a topic of public concern. To characterize the long-term temporal trend and age-at-exposure variation in the radiation-induced risk of thyroid cancer, we analyzed thyroid cancer incidence data for the period from 1958 through 2005 among 105,401 members of the Life Span Study cohort of Japanese atomic-bomb survivors. During the follow-up period, 371 thyroid cancer cases (excluding those with microcarcinoma with a diameter 50 years after exposure. PMID:22847218

  9. Epidemiological studies among the offspring (F1) of atomic bomb survivors

    International Nuclear Information System (INIS)

    On the basis of results of surveys for the frequency of malignant tumors during the period 1946-1982 and mortality during the period 1946-1985 among the offspring of A-bomb survivors, genetic effects of A-bombing were retrospectively investigated. Among 67,574 children born to parents whose gonad doses could be estimated, 83 in the age group of 20 years or younger were found to develop cancer. Of these, only 18 were considered to have genetic cancers, such as retinoblastoma, Wilms tumor, neuroblastoma, osteosarcoma, and embryonal carcinoma. The other 31 and 34 patients had leukemia and other cancers, respectively. No significantly increased incidence of cancer was associated with radiation doses received in their parents. Genetic effects of A-bombing were considered responsible for 3% to 5% of spontaneously induced malignant tumors. Among 67,586 children born to parents whose gonad doses could be estimated, 3852 (5.7%) were dead during the period 1946-1985. Of these, 76% had died before the age of 4. Survey for mortality has also showed that there is no significant correlation between gonad doses in parents and cancer risk for their offspring. (N.K.)

  10. Cytogenetic study of the offspring of atomic bomb survivors, Hiroshima and Nagasaki

    International Nuclear Information System (INIS)

    The main objective of the present study is to evaluate the radiation sensitivity of human germ-cell chromosomes by measuring the frequency of children with chromosome changes in structure or number induced by radiation in the germ cells of exposed parents. It is expected that stable chromosome aberrations, if induced in the germ cells, would be mot likely transmitted to the offspring. Although there is no evidence of chromosome aneuploidy being induced by radiation exposure in humans, it is difficult to exclude the possibility that abnormalities, such as XYY and XXX, would be induced in the offspring. The present chapter describes the results of somatic chromosome analysis of 8,322 children born to A-bomb survivors in Hiroshima and Hagasaki and 7,976 children born to parents who had received less than 1 rad (distally exposed) or were not in the cities (NIC) at the time of the bomb (ATB). Chromosome analyses were based mostly on nonbanded preparations throughout the study. Because of the recent, extensive reassessment of A-bomb dosimetry by a US-Japan team of experts, the present study samples have been divided into exposed and control groups based on the T65DR system that has been routinely used until recently at RERF. The data base for the new DS86 dose system has been entered into the RERF computer; however, calculations of the individual dose estimates for each survivor are now in progress, but are not available at this time. For this reason, no attempt has been made to analyze the present data in terms of parental radiation doses

  11. A chromosome study of 6-thioguanine-resistant mutants in T lymphocytes of Hiroshima atomic bomb survivors

    International Nuclear Information System (INIS)

    Cytogenetic characterizations were made of lymphocyte colonies established from somatic mutation assays for 6-thioguanine (TG) resistance in Hiroshima atomic bomb survivors. G-banded chromosomes were analyzed in both TG-resistant (TGr) and wild-type (not TG-selected) colonies. Included were 45 TGr and 19 wild-type colonies derived from proximally exposed A-bomb survivors, as well as colonies from distally exposed control individuals who were not exposed to a significant level of A-bomb radiation (18 TGr and 9 wild-type colonies). Various structural and numerical abnormalities of chromosomes were observed in both TGr and wild-type colonies. Aberrations of the X chromosome, on which the hypoxanthine guanine phosphoribosyltransferase (HPRT) locus is present, were found in six colonies: two resistant colonies from controls [45,X/46,XX; 46,X,ins(X)], three resistant colonies [45,X/46,XX/46,X,+mar; 46,X,t(Xq+;14q-); 46,Y,t(Xq-;5q+)], and one wild-type colony [45,X/47,XXX] from proximally exposed persons. In cases with exchange aberrations, each of the break points on the X chromosome was situated proximally to band q26 where the HPRT locus is known to be assigned. DNA replicating patterns were also studied, and it was found that abnormal X chromosomes showed early replicating patterns, while normal X chromosomes showed late replicating patterns. (author)

  12. CD14 and IL18 gene polymorphisms associated with colorectal cancer subsite risks among atomic bomb survivors.

    Science.gov (United States)

    Hu, Yiqun; Yoshida, Kengo; Cologne, John B; Maki, Mayumi; Morishita, Yukari; Sasaki, Keiko; Hayashi, Ikue; Ohishi, Waka; Hida, Ayumi; Kyoizumi, Seishi; Kusunoki, Yoichiro; Tokunaga, Katsushi; Nakachi, Kei; Hayashi, Tomonori

    2015-01-01

    Colorectal cancer (CRC) is a common malignancy worldwide, and chronic inflammation is a risk factor for CRC. In this study, we carried out a cohort study among the Japanese atomic bomb (A-bomb) survivor population to investigate any association between immune- and inflammation-related gene polymorphisms and CRC. We examined the effects of six single-nucleotide polymorphisms of CD14 and IL18 on relative risks (RRs) of CRC. Results showed that RRs of CRC, overall and by anatomic subsite, significantly increased with increasing radiation dose. The CD14-911A/A genotype showed statistically significant higher risks for all CRC and distal CRC compared with the other two genotypes. In addition, the IL18-137 G/G genotype showed statistically significant higher risks for proximal colon cancer compared with the other two genotypes. In phenotype-genotype analyses, the CD14-911A/A genotype presented significantly higher levels of membrane and soluble CD14 compared with the other two genotypes, and the IL18-137 G/G genotype tended to be lower levels of plasma interleukin (IL)-18 compared with the other two genotypes. These results suggest the potential involvement of a CD14-mediated inflammatory response in the development of distal CRC and an IL18-mediated inflammatory response in the development of proximal colon cancer among A-bomb survivors. PMID:27081544

  13. Long-term Radiation-Related Health Effects in a Unique Human Population: Lessons Learned from the Atomic Bomb Survivors of Hiroshima and Nagasaki

    OpenAIRE

    Douple, Evan B.; Mabuchi, Kiyohiko; Cullings, Harry M.; Preston, Dale L.; Kodama, Kazunori; Shimizu, Yukiko; Fujiwara, Saeko; Shore, Roy E.

    2011-01-01

    For 63 years scientists in the Atomic Bomb Casualty Commission and its successor, the Radiation Effects Research Foundation, have been assessing the long-term health effects in the survivors of the atomic bombings of Hiroshima and Nagasaki and in their children. The identification and follow-up of a large population (approximately a total of 200 000, of whom more than 40% are alive today) that includes a broad range of ages and radiation exposure doses, and healthy representatives of both sex...

  14. Report on the results of the twelfth medical examination of atomic bomb survivors residing in North America

    Energy Technology Data Exchange (ETDEWEB)

    Yamamoto, Yasuji [Hiroshima Prefectural Medical Association (Japan); Ohama, Koso; Fujiwara, Saeko (and others)

    2000-06-01

    The twelfth medical examination of atomic bomb survivors residing in North America, was conducted in San Francisco and Seattle from May 20 through June 2 1999, and in Los Angeles and Hawaii from June 9 through 23 1999, The examination included an interview, measurement of height, weight, and blood pressure, an ECG, urine and stool tests, blood tests, a physical examination, examination of the breast, thyroid, and rectum by a surgeon, and screening for uterine cancer and a gynecological interview and examination by an obstetrician and gynecologist. The total confirmed number of A-bomb survivors residing in North America as of the end of June 1999 was 1076. Of the 1062 survivors that remained after excluding the 14 subjects whose survey was incomplete, 279 males and 654 females had been exposed in Hiroshima, and 10 males and 119 females in Nagasaki. The peak age at the time of exposure in both sexes was 15-19 years, followed by 10-14 years. The number of survivors exposed <2000 m from the hypocenter was 236, accounting for 21.9% of the total. The confirmed number of survivors exposed in utero was 26. The survivors' age (mean {+-}S.D.) was: 69.0{+-}8.69 years; males, 68.4{+-}80.5 years; females, 69.2{+-}8.91 years. A total of 414 survivors were examined (male 129; female 285; mean age 68.0 years). Approximately 80% of the examinees had experienced at least one general symptom. Many still complain of symptoms that suggest possible posttraumatic stress disorder as a result of exposure to the A-bomb. It will be necessary to consider providing mental health care by psychiatrists beginning with the next examination. The prevalence of life-style diseases has been gradually increased with age. A previous history of cancer was found in 9.2% of the examinees. The most prevalent was of breast cancer, followed by malignant tumors of the colon, rectum, uterus, brain, stomach, and thyroid. The need for cancer screening and promotion of life-style education was keenly felt. (K.H.)

  15. Report on the results of the twelfth medical examination of atomic bomb survivors residing in North America

    International Nuclear Information System (INIS)

    The twelfth medical examination of atomic bomb survivors residing in North America, was conducted in San Francisco and Seattle from May 20 through June 2 1999, and in Los Angeles and Hawaii from June 9 through 23 1999, The examination included an interview, measurement of height, weight, and blood pressure, an ECG, urine and stool tests, blood tests, a physical examination, examination of the breast, thyroid, and rectum by a surgeon, and screening for uterine cancer and a gynecological interview and examination by an obstetrician and gynecologist. The total confirmed number of A-bomb survivors residing in North America as of the end of June 1999 was 1076. Of the 1062 survivors that remained after excluding the 14 subjects whose survey was incomplete, 279 males and 654 females had been exposed in Hiroshima, and 10 males and 119 females in Nagasaki. The peak age at the time of exposure in both sexes was 15-19 years, followed by 10-14 years. The number of survivors exposed <2000 m from the hypocenter was 236, accounting for 21.9% of the total. The confirmed number of survivors exposed in utero was 26. The survivors' age (mean ±S.D.) was: 69.0±8.69 years; males, 68.4±80.5 years; females, 69.2±8.91 years. A total of 414 survivors were examined (male 129; female 285; mean age 68.0 years). Approximately 80% of the examinees had experienced at least one general symptom. Many still complain of symptoms that suggest possible posttraumatic stress disorder as a result of exposure to the A-bomb. It will be necessary to consider providing mental health care by psychiatrists beginning with the next examination. The prevalence of life-style diseases has been gradually increased with age. A previous history of cancer was found in 9.2% of the examinees. The most prevalent was of breast cancer, followed by malignant tumors of the colon, rectum, uterus, brain, stomach, and thyroid. The need for cancer screening and promotion of life-style education was keenly felt. (K.H.)

  16. Dedifferentiated Liposarcoma in the Retroperitoneum in an Atomic Bomb Survivor: Report of a Case

    Directory of Open Access Journals (Sweden)

    Yukio Nakamura

    2008-09-01

    Full Text Available A 76-year-old Japanese man was admitted to Kosei-Nenkin Hospital (Osaka, Japan in November 2006; his chief complaint was a 10-kg loss in body weight over 3 months prior to admission. Abdominal computed tomography (CT and dynamic magnetic resonance imaging (MRI showed three masses in the retroperitoneum. The patient subsequently underwent surgery. The final histopathological diagnosis of tumors 1 and 2 was malignant fibrous histiocytoma of the retroperitoneum, and tumor 3 was a well-differentiated liposarcoma. By the presence of the liposarcoma, tumor 1 and 2 were thought to be the dedifferentiated areas of liposarcomas. At the age of 16, the patient had been exposed to radiation from the atomic bomb at Hiroshima towards the end of the Second World War. We postulate that in this case, radiation from the atomic bomb may have played an important role in the development of the sarcomas.

  17. Comparison of Medical Data of Atomic-Bomb Survivors Resident in the U.S. and Hiroshima

    OpenAIRE

    Ito, Chikako; Matsubara, Hiroomi; Yamakido, Michio; Yamada, Hiroaki

    1982-01-01

    The third medical examination of A-bomb survivors residing in the U.S. was performed in San Francisco, Los Angeles, Seattle and Honolulu during the period 6-28 May 1981. The test results were studied and the actual state of the survivors in the U. S., was reviewed as explained hereunder.1) The number of survivors actually registered with the Committee of A-bomb Survivors in the U.S. is 491 (133 males and 358 females) of whom 57.2% are U.S. citizens. Those exposed in Hiroshima accounted for 91...

  18. Relationship of stature to gamma and neutron exposure among atomic bomb survivors aged less than 10 at the time of the bomb, Hiroshima and Nagasaki

    International Nuclear Information System (INIS)

    A reanalysis has been undertaken of the relationship of attained adult height of Hiroshima and Nagasaki atomic bomb survivors aged less than 10 at the time of the bomb (ATB) to radiation dose based upon new dosimetry data. The present analysis aims to examine the relationship of stature to radiation dose in terms of gamma rays and neutrons, separately. The 628 individuals were selected from Hiroshima and Nagasaki survivors, aged less than 10 ATB, whose doses were available, and whose statures were recorded at the Adult Health Study (AHS) biennial health examination during 1970-72. To ascertain the relationship of attained adult stature to gamma and neutron doses three doseresponse models were applied to the data. The analysis revealed that the attained height is a separate function of exposure to gamma rays and neutrons. The model assuming a squared term dependence on gamma rays and a linear dependence on neutrons provides a better explanation of the data. The regression coefficient associated with the squared gamma dose is -0.00000927 and the coefficient associated with neutron dose is -0.0172. The relative biological effectiveness of neutrons in relation to gamma radiation with respect to the effect for diminished development of stature is estimated as 43.1 / √Dn in kerma (Dn=neutron dose). The 95% confidence limits are 19.3 / √Dn--96.5 / √Dn. (author)

  19. Survival experience of atomic bomb survivors, Hiroshima and Nagasaki, 1951 - 76

    International Nuclear Information System (INIS)

    This report is a review of the experience of persons in the Life Span Study sample exposed to the atomic bombs in 1945 as reflected by survival rates for the period 1951-76. The greatest effect is on the population less than 10 years of age at the time of the bombs (ATB) exposed to 100 rad or more. The survival rates for both sexes in the two cities declined significantly below those for the controls. This change occurred after a latent period. There has been an unusual acceleration in the decline in survival rates for the group aged 25 - 44 years ATB but this does not appear to be raidation related inasmuch as both the exposed and nonexposed populations in the two cities are similarly affected. (author)

  20. Metabolic Profile as a Potential Modifier of Long-Term Radiation Effects on Peripheral Lymphocyte Subsets in Atomic Bomb Survivors.

    Science.gov (United States)

    Yoshida, Kengo; Nakashima, Eiji; Kyoizumi, Seishi; Hakoda, Masayuki; Hayashi, Tomonori; Hida, Ayumi; Ohishi, Waka; Kusunoki, Yoichiro

    2016-09-01

    Immune system impairments reflected by the composition and function of circulating lymphocytes are still observed in atomic bomb survivors, and metabolic abnormalities including altered blood triglyceride and cholesterol levels have also been detected in such survivors. Based on closely related features of immune and metabolic profiles of individuals, we investigated the hypothesis that long-term effects of radiation exposure on lymphocyte subsets might be modified by metabolic profiles in 3,113 atomic bomb survivors who participated in health examinations at the Radiation Effect Research Foundation, Hiroshima and Nagasaki, in 2000-2002. The lymphocyte subsets analyzed involved T-, B- and NK-cell subsets, and their percentages in the lymphocyte fraction were assessed using flow cytometry. Health examinations included metabolic indicators, body mass index, serum levels of total cholesterol, high-density lipoprotein cholesterol, C-reactive protein and hemoglobin A1c, as well as diabetes and fatty liver diagnoses. Standard regression analyses indicated that several metabolic indicators of obesity/related disease, particularly high-density lipoprotein cholesterol levels, were positively associated with type-1 helper T- and B-cell percentages but were inversely associated with naïve CD4 T and NK cells. A regression analysis adjusted for high-density lipoprotein cholesterol revealed a radiation dose relationship with increasing NK-cell percentage. Additionally, an interaction effect was suggested between radiation dose and C-reactive protein on B-cell percentage with a negative coefficient of the interaction term. Collectively, these findings suggest that radiation exposure and subsequent metabolic profile changes, potentially in relationship to obesity-related inflammation, lead to such long-term alterations in lymphocyte subset composition. Because this study is based on cross-sectional and exploratory analyses, the implications regarding radiation exposure, metabolic

  1. Anti-Human T-Lymphotropic Virus Type-I Antibodies in Atomic-Bomb Survivors

    OpenAIRE

    Matsuo, Tatsuki; Nakashima, Eiji; Carter, Randolph L.; Neriishi, Kazuo; Mabuchi, Kiyohiko; Akiyama, Mitoshi; Shimaoka, Katsutaro; Kinoshita, Ken-Ichiro; Tomonaga, Masao; Ichimaru, Michito

    1995-01-01

    Adult T-cell leukemia (ATL), induced by human T-lymphotropic virus type-I (HTLV-I), is endemic in Nagasaki, Japan. To investigate the effects of atomic-bomb radiation on development of this specific type of leukemia, 6182 individuals in the Radiation Effects Research Foundation (RERE) Adult Health Study sample in Hiroshima and Nagasaki were examined for positive rate of HTLV-I antibody. Several lymphocyte parameters were also studied for 70 antibody-positive subjects in Nagasaki. The HTLV-I a...

  2. Report on the results of the tenth medical examination of atomic bomb survivors resident in North America

    Energy Technology Data Exchange (ETDEWEB)

    Shibata, Jun [Hiroshima Prefectural Medical Association (Japan); Ohta, Nobuhiro; Sasaki, Hideo [and others

    1996-01-01

    The 10th medical examination of A-bomb survivors resident in North America was conducted from 6 June to 6 July 1995 in L.A., S.F., Seattle, Wailuku, and Honolulu. Since this is the 10th medical examination, results of the previous examination are summarized. With the exclusion of 55 whose death has been confirmed, the total registered number of A-bomb survivors resident in North America is 1,043. The examinees in the present examination amounted to 463 (48 of them are the children of A-bomb survivors), 26 of whom are newly registered survivors. The mean age of the examinees in 64 years. The proportion of those having US nationality gradually increased and reached 62% at the time of the 10th examination, while that of those who have Japanese nationality and permanent US residency rights decreased to 30%. When the examination program was initiated, A-bomb survivors resident in 15 states of the US, but now, in Canada and 31 states of the US. About 90% of these survivors reside along the west coast of the US including Hawaii. The number of holders of A-bomb survivor`s health handbook has increased year after year, reaching 612. When the holders in North-America visit Japan for medical treatment, they are treated similarly with their counterparts in Japan. The major subjective symptoms are complete exhaustion or fatigue, heat intolerance, loss of vigor, and numbness or tingling. The prevalence of obesity, hypertension, and diabetes mellitus and the proportion of abnormal ECG findings has been increasing with the age. The prevalence of hypercholesterolemia was high and that of low HDL cholesterolemia was low. A significant difference was observed between the A-bomb survivors in Hiroshima and North America. Hypertension, hyperlipidemia, obesity, ischemic heart disease, and diabetes mellitus were observed mainly. Diseased of specific places were not observed. (H.O.).

  3. Report on the results of the fifteenth medical examination of atomic bomb survivors resident in North America

    International Nuclear Information System (INIS)

    The fifteenth medical examination of A-bomb survivors resident in North America was carried out from May 11th through May 25th and from June 15th through June 29th, 2005, in the cities of Los Angeles, San Francisco, Seattle, and Honolulu. The total number of those who underwent the fifteenth medical examination was 435, 68 of whom were second-generation A-bomb survivors. As the survivors in North America are advancing in age, the average age of the examinees was 73.1 years. The examination items included an interview, clinical and physical examinations, electrocardiography (E.C.G.), and blood, urine, and stool tests. The review of the medical history showed that hypertension was the most frequent in the survivors examined, with the prevalence of 51.8%. Previous history of malignant tumors was observed in 19.6% of the survivors examined, with major sites being the mammary gland, uterus, colon, and prostate. As a result of the blood test, 12.8% of the survivors examined were diagnosed as diabetic, and hypercholesterolemia was found in 26.2% of the survivors examined. Latent hypothyroidism was found in 16.9% of the survivors examined. Among the examinees of A-bomb survivors, statistically significant associations with exposure status were not found in any disease or examination finding. A report providing the results of the medical examination and the necessity of undergoing closer examination and receiving medical treatment, if any, was mailed to each examinee. (author)

  4. Radiation May Indirectly Impair Growth Resulting in Reduced Standing Height via Subclinical Inflammation in Atomic-Bomb Survivors Exposed at Young Ages

    OpenAIRE

    Eiji Nakashima; Kazuo Neriishi; Wan-Ling Hsu

    2015-01-01

    For young atomic-bomb (A-bomb) survivors, A-bomb radiation’s (total) effect on standing height is thought to comprise the sum of direct effect and indirect effect via inflammation. With the data of five inflammatory markers—white blood cell count, sialic acid, corrected erythrocyte sedimentation rate (ESR), α1 globulin, and α2 globulin—obtained in adulthood during the period 1988 to 1992, a summary inflammatory index was constructed as a surrogate for the five subclinical inflammatory markers...

  5. Study of the titers of Anti-Epstein-Barr virus antibodies in the sera of atomic bomb survivors

    International Nuclear Information System (INIS)

    Antibody titers to Epstein-Barr virus antigens were determined in the sera of 372 atomic bomb survivors to evaluate the effect of the previous radiation exposure on immune competence against the latent infection of the virus. The proportion of persons with high titers (≥ 1:40) of IgG antibodies to the early antigen was significantly elevated in the exposed survivors. Furthermore, the distribution of IgM titers against the viral capsid antigen was significantly affected by radiation dose with an increased occurrence of titers of 1:5 and 1:10 in the exposed persons, although the dose effect was only marginally suggestive when persons with rheumatoid factor were eliminated from the analysis. These results suggest that reactivation of Epstein-Barr virus in the latent stage occurs more frequently in the survivors, even though this might not be affected by the radiation dose. Otherwise, there was neither an increased trend in the prevalence of high titers (≥ 1:640) of IgG antibodies to the viral capsid antigen among the exposed people nor a correlation between the radiation exposure and distributions of titers of IgA antibodies to the viral capsid antigen or antibodies to the anti-Epstein-Barr virus-associated nuclear antigen. (author)

  6. Report on the results of the tenth medical examination of atomic bomb survivors resident in North America

    International Nuclear Information System (INIS)

    The 10th medical examination of A-bomb survivors resident in North America was conducted from 6 June to 6 July 1995 in L.A., S.F., Seattle, Wailuku, and Honolulu. Since this is the 10th medical examination, results of the previous examination are summarized. With the exclusion of 55 whose death has been confirmed, the total registered number of A-bomb survivors resident in North America is 1,043. The examinees in the present examination amounted to 463 (48 of them are the children of A-bomb survivors), 26 of whom are newly registered survivors. The mean age of the examinees in 64 years. The proportion of those having US nationality gradually increased and reached 62% at the time of the 10th examination, while that of those who have Japanese nationality and permanent US residency rights decreased to 30%. When the examination program was initiated, A-bomb survivors resident in 15 states of the US, but now, in Canada and 31 states of the US. About 90% of these survivors reside along the west coast of the US including Hawaii. The number of holders of A-bomb survivor's health handbook has increased year after year, reaching 612. When the holders in North-America visit Japan for medical treatment, they are treated similarly with their counterparts in Japan. The major subjective symptoms are complete exhaustion or fatigue, heat intolerance, loss of vigor, and numbness or tingling. The prevalence of obesity, hypertension, and diabetes mellitus and the proportion of abnormal ECG findings has been increasing with the age. The prevalence of hypercholesterolemia was high and that of low HDL cholesterolemia was low. A significant difference was observed between the A-bomb survivors in Hiroshima and North America. Hypertension, hyperlipidemia, obesity, ischemic heart disease, and diabetes mellitus were observed mainly. Diseased of specific places were not observed. (H.O.)

  7. Age-related alteration in the composition of immunocompetent blood cells in atomic bomb survivors

    International Nuclear Information System (INIS)

    1328 survivors of Hiroshima were studied for alterations in the number of blood lymphocytes belonging to T-cell subpopulations, CD19 antigen-positive B cells and Leu 7 and CD16 antigen-positive lymphocytes. With increasing age, significant decreasing trends in the numbers of some lymphocytes in T-cell subpopulations and of B-cells were seen. The number of blood lymphocytes positive for CD5 antigen was significantly lower in those exposed to radiation (> 1Gy) in the older age group (more than 30 years at the time of bombing) and a similar tendency for decreases in the numbers of CD4, CD8, and CD19 antigen-positive cells was observed, but differences were not significant. The results suggest aging of the T-cell related immune system is accelerated in the irradiated people of advanced age, explained by the age-related decrease in thymic function in those subjects. The number of Leu 7 or CD19 antigen-positive cells was found to be increased significantly in the older age group compared to the younger, although there was little dose dependence. (U.K.)

  8. Histologic review of breast cancer cases in survivors of atomic bombs in Hiroshima and Nagasaki, Japan.

    Science.gov (United States)

    Tokuoka, S; Asano, M; Yamamoto, T; Tokunaga, M; Sakamoto, G; Hartmann, W H; Hutter, R V; Land, C E; Henson, D E

    1984-09-01

    A panel of Japanese and American pathologists reviewed existing histologic material used to study breast cancer risk among the A-bomb survivors in Hiroshima and Nagasaki, a population in which incidence studies have found a strong relationship between breast cancer risk and radiation dose. The primary charge to the panel was to define a body of confirmed cases in the Life Span Study sample of the Radiation Effects Research Foundation that would require little or no review for inclusion in future studies of breast cancer incidence. Broad agreement on histologic type was reached for 298 of 300 confirmed cases. The distribution of histologic types was, overall, similar to that seen in other studies of breast cancer in Japanese women, and did not appear to depend on dose; thus radiation-induced breast cancer appeared to be no different histologically from other breast cancer. Also, no evidence was found of variation in histologic type by city, age at exposure, age at diagnosis, or calendar time. PMID:6331630

  9. Comment on the treatment of dose-response relationship for the epidemiological data of atomic bomb survivors

    Energy Technology Data Exchange (ETDEWEB)

    Matsuura, Tatsuo [Radiation Education Forum, Tokyo (Japan)

    2000-05-01

    As for the dose-response relationship for solid cancer incidence rate at low dose radiation, the epidemiological study of atomic bomb survivors by RERF have been regarded to be the most important and authentic, and ICRP has its conceptual basis in the policy of radiation protection on this data for adopting the linear, non-threshold (LNT) model. However, we have found that there are two fundamental problems in the way of treatment of the data, and we believe it may bring an important modification on the validity of the LNT model for the interpretation of the radiation effect at low dose. The first point is that in estimating the exposure dose of the survivors, the chronic dose received by them should be considered in addition to the acute dose calculated by T65D or DS86, which only estimates the dose at the instant of explosion of the bomb. It seems there are ample evidences that the survivors received additional chronic dose due to the radioactivity contained both in the fallout and in the induced radioactivity by the neutron bombardment of the environmental materials. For example, it is a well-known fact that there was a heavy temporary shower (so to speak ''black rain'') in a wide region of the city after the bomb explosion, which contained much radioactivity due to the fission products. According to a literature, in the case of residents at Nishiyama District in Nagasaki, which is located 3 km from the explosion center but is shielded by a mountain from the instantaneous bomb explosion, the cumulative dose received by 280 residents there was estimated to be as much as 0.2 Gy, which caused an abnormal increase in the number of leukocytes for most of the residents. For the case of Hiroshima, a literature reports that the dose due to the black rain was about 0.03-0.04 Gy. In both cities, a substantial percentage of the survivors had stayed for considerable time in the contaminated area in the city after bombing, such as for the purpose of

  10. A review of forty-five years study of Hiroshima and Nagasaki atomic bomb survivors. Cancer risk among in utero-exposed survivors.

    Science.gov (United States)

    Yoshimoto, Y; Kato, H; Schull, W J

    1991-03-01

    The Radiation Effects Research Foundation (RERF) continues to conduct a follow-up study initiated some years ago of cancer mortality and incidence among the survivors of the atomic bombing of Hiroshima and Nagasaki exposed in utero. Although only 18 incident cases of cancer were identified in the years 1950-1984 (of which 5 cases were in the 0 dose group), cancer risk appears to increase significantly as maternal uterine dose increases. Only two cases of childhood cancer were observed among these individuals in the first 14 years of life; both had been exposed to greater than or equal to 0.30 Gy. All other cases developed cancer in adulthood, and the cancers they developed are, in the main, the ones known to be elevated in frequency among the postnatally exposed survivors. The estimated relative risk for cancer at 1 Gy (uterine dose) is 3.77. The results suggest that the in utero group may have a higher risk than that seen among exposed adults because the individuals exposed in utero have not reached the major cancer prone age. However, since the observed cases are too few to allow a site-specific review, further follow-up studies are required to determine if the observed increased cancer risk can definitely be attributed to A-bomb radiation, although there appears to be a significant dose-related cancer response. PMID:1762110

  11. Radiosensitivity of skin fibroblasts from atomic bomb survivors with and without breast cancer

    International Nuclear Information System (INIS)

    Fibroblasts were established in vitro from skin biopsies obtained from 55 women and one man with or without breast cancer and with or without exposure to radiation from the atomic bomb explosion in Hiroshima. The radiosensitivity of these cells was evaluated by clonogenic assays after exposure to X rays or to fission neutrons from a 252Cf source. Data were fitted to a multitarget model, S/S0 = A[1-(1-ekD)N], for both X-ray and neutron dose-survival curves. A single-hit model, S/S0 = AekD, fits the neutron dose-survival responses as well. These was no difference in the means or variances of radiosensitivity between exposed and nonexposed groups, or between patients with or without breast cancer. Hence, although the sample is not large, it provides no support for the hypothesis that A-bomb radiation preferentially induces breast cancer in women whose cells in vitro are sensitive to cell killing by radiation. (author)

  12. 41Ca a market for the first biological signature of neutron exposure of the atomic-bomb survivors in Hiroshima

    International Nuclear Information System (INIS)

    The health data from the atomic-bomb survivors of Hiroshima and Nagasaki serve as the prime basis for risk estimates of delayed effects induced by ionizing radiation. Dose estimates have been performed by means of the dosimetry system DS86 which allows the calculation of individual doses. Up to now a variety of long-lived radionuclides such as 32P (T1/2 = 14.3d), 60Co (T1/2 = 5.27y), 152Eu (T1/2 = 13.3y), 36Cl (T1/2 300000y), '41Ca (T1/2 = 103000y) and 63Ni (T1/2 = 101.4y) have been used for validation of DS86 neutron fluences. All of these isotopes were measured in inorganic materials, such as granite, concrete or copper

  13. Liver cancer in atomic-bomb survivors. Histological characteristics and relationships to radiation and hepatitis B and C viruses

    Energy Technology Data Exchange (ETDEWEB)

    Fukuhara, Toshiyuki [Hiroshima Prefectural Hospital (Japan); Sharp, G.B.; Mizuno, Terumi (and others)

    2001-06-01

    Histological features of primary liver cancer among atomic-bomb survivors and their relationship to hepatitis B (HBV) and C viral (HCV) infections are of special interest because of the increased risk of liver cancer in persons exposed to ionizing radiation and the high and increasing liver cancer rates in Japan and elsewhere. We conducted a pathology review of liver cancers occurring from 1958 to 1987 among subjects in the 120,321 member cohort of 1945 Hiroshima and Nagasaki residents. A panel of pathologists classified tumor histological types and defined accompanying cirrhotic changes of the liver. Archival tissue samples were assessed for HBV using pathology stains and PCR. Reverse transcriptase (RT) PCR was used to determine HCV status. We used unconditional logistic regression to compare 302 hepatocellular carcinoma (HCC) cases to 53 cholangiocarcinoma (CC) cases, adjusting for age, year of diagnosis, sex and viral status. Cirrhotic changes occurred significantly more often among HCC than CC cases (76% in HCC and 6% in CC). Compared to CC cases, HCC cases were 10.9 times more likely to be HBV-positive (95% confidence interval: 2.1-83.2) and 4.3 times more likely to be HCV-positive (95% confidence interval: 1.1-20.5) No significant differences were found between HCC and CC cases in radiation exposures. The predominance of HCC in the atomic-bomb survivors follows the background liver cancer pattern in Japan. Our findings suggest that HBV and HCV are involved in the pathogenesis of HCC with or without cirrhosis and are significantly less important in that of CC. (author)

  14. Cancer incidence in atomic bomb survivors. Part II: Solid tumors, 1958-1987

    International Nuclear Information System (INIS)

    This report presents, for the first time, comprehensive data on the incidence of solid cancer and risk estimates for A-bomb survivors in the extended Life Span Study (LSS-E85) cohort. Among 79,972 individuals, 8613 first primary solid cancers were diagnosed between 1958 and 1987. As part of the standard registration process of the Hiroshima and Nagasaki tumor registries, cancer cases occurring among members of the LSS-E85 cohort were identified using a computer linkage system supplemented by manual searches. Special efforts were made to ensure complete case ascertainment, data quality and data consistency in the two cities. For all sites combined, 75% of the cancers were verified histologically, 6% were diagnosed by direct observation, 8% were based on a clinical diagnosis, and 12.6% were ascertained by death certificate only. A standard set of analyses was carried out for each of the organs and organ systems considered. Depending on the cancer site, Dosimetry System 1986 (DS86) organ or kerma doses were used for computing risk estimates. Analyses were based on a general excess relative risk model (the background rate times one plus the excess relative risk). Analyses carried out for each site involved fitting the background model with no dose effect, a linear dose-response model with no effect modifiers, a linear-quadratic dose-response model with no effect modifiers, and a series of linear dose-response models that included each of the covariates (sex, age at exposure, time since exposure, attained age and city) individually as effect modifiers. Because the tumor registries ascertain cancers in the registry catchment areas only, an adjustment was made for the effects of migration. In agreement with prior LSS findings, a statistically significant excess risk for all solid cancers was demonstrated. 116 refs., 8 figs., 78 tabs

  15. Cancer incidence in atomic bomb survivors. Part II: Solid tumors, 1958-1987.

    Science.gov (United States)

    Thompson, D E; Mabuchi, K; Ron, E; Soda, M; Tokunaga, M; Ochikubo, S; Sugimoto, S; Ikeda, T; Terasaki, M; Izumi, S

    1994-02-01

    This report presents, for the first time, comprehensive data on the incidence of solid cancer and risk estimates for A-bomb survivors in the extended Life Span Study (LSS-E85) cohort. Among 79,972 individuals, 8613 first primary solid cancers were diagnosed between 1958 and 1987. As part of the standard registration process of the Hiroshima and Nagasaki tumor registries, cancer cases occurring among members of the LSS-E85 cohort were identified using a computer linkage system supplemented by manual searches. Special efforts were made to ensure complete case ascertainment, data quality and data consistency in the two cities. For all sites combined, 75% of the cancers were verified histologically, 6% were diagnosed by direct observation, 8% were based on a clinical diagnosis, and 12.6% were ascertained by death certificate only. A standard set of analyses was carried out for each of the organs and organ systems considered. Depending on the cancer site, Dosimetry System 1986 (DS86) organ or kerma doses were used for computing risk estimates. Analyses were based on a general excess relative risk model (the background rate times one plus the excess relative risk). Analyses carried out for each site involved fitting the background model with no dose effect, a linear dose-response model with no effect modifiers, a linear-quadratic dose-response model with no effect modifiers, and a series of linear dose-response models that included each of the covariates (sex, age at exposure, time since exposure, attained age and city) individually as effect modifiers. Because the tumor registries ascertain cancers in the registry catchment areas only, an adjustment was made for the effects of migration. In agreement with prior LSS findings, a statistically significant excess risk for all solid cancers was demonstrated [excess relative risk at 1 Sv (ERR1Sv) = 0.63; excess absolute risk (EAR) per 10(4) person-year sievert (PY Sv) = 29.7]. For cancers of the stomach (ERR1SV = 0.32), colon

  16. Report on the results of the sixth medical examination of atomic bomb survivors resident in the South America

    Energy Technology Data Exchange (ETDEWEB)

    Oda, Hiroaki [Hiroshima Univ. (Japan). School of Medicine; Hirata, Katsumi; Taguchi, Atsushi; Sakamoto, Fumio; Nawachi, Sadahiro; Terada, Kensaku

    1995-11-01

    The medical examination of A-bomb survivors was carried out in Brazil, Argentina, Bolivia, Republic of Peru, and Paraguay from October 25th to November 11th 1994. The survivors were 191 persons, and 98 (51.3%) of them received health consultation. Sixty-two persons were exposured in Hiroshima and 36 in Nagasaki. Average age of the medical examinee was 65.0{+-}8.5-year-old. The holding rate of A-bomb survivor`s handbook was 55.1%. The lowered physical vitality and the involution of the mental vitality with increased age were observed from interview sheets. This first orthopedic examination revealed abnormal findings in 12 persons. Sixty-five persons required further examinations. Cardiovascular risk factors of such as hypertension, obesity, hyperlipidemia and diabetes mellitus were observed. (H.O.).

  17. Report on the results of the thirteenth medical examination of atomic bomb survivors resident in north america

    Energy Technology Data Exchange (ETDEWEB)

    Yamamoto, Yasuji; Ohta, Michiya [Hiroshima Prefectural Medical Association (Japan); Urabe, Takeshi [Hiroshima Prefectural Hospital (Japan)] [and others

    2002-05-01

    The thirteenth medical examination of A-bomb survivors resident in North America was carried out from June 13th through June 27th and from July 12th through July 26th, 2001, in the cities of Los Angeles, San Francisco, Seattle, and Honolulu. The total number of those who underwent the thirteenth medical examination was 399, 53 of whom were second-generation A-bomb survivors. As the survivors in North America are advancing in age, the average age of the examinee was 69.5 years. The examination items included an interview, clinical and physical examinations, electrocardiography (E.C.G.), and blood, urine, and stool tests. The review of the medical history showed that hypertension was the most frequent in the survivors examined, with the prevalence of 39.3%. Previous history of malignant tumors was observed in 13.6% of the survivors examined, with major sites being the mammary gland, uterine, and colon. As a result of the blood test, 9.5% of the survivors examined were diagnosed as diabetic, and hypercholesterolemia was found in 32.1% of the survivors examined. Latent hypothyroidism was found in 18.5% of the survivors examined. No disease or examination finding showed a clear relation with exposure status. A report providing the results of the medical examination and necessity of undergoing closer examination and receiving medical treatment, if any, was mailed to each examinee. (author)

  18. Effect of recent changes in atomic bomb survivor dosimetry on cancer mortality risk estimates.

    Science.gov (United States)

    Preston, Dale L; Pierce, Donald A; Shimizu, Yukiko; Cullings, Harry M; Fujita, Shoichiro; Funamoto, Sachiyo; Kodama, Kazunori

    2004-10-01

    The Radiation Effects Research Foundation has recently implemented a new dosimetry system, DS02, to replace the previous system, DS86. This paper assesses the effect of the change on risk estimates for radiation-related solid cancer and leukemia mortality. The changes in dose estimates were smaller than many had anticipated, with the primary systematic change being an increase of about 10% in gamma-ray estimates for both cities. In particular, an anticipated large increase of the neutron component in Hiroshima for low-dose survivors did not materialize. However, DS02 improves on DS86 in many details, including the specifics of the radiation released by the bombs and the effects of shielding by structures and terrain. The data used here extend the last reported follow-up for solid cancers by 3 years, with a total of 10,085 deaths, and extends the follow-up for leukemia by 10 years, with a total of 296 deaths. For both solid cancer and leukemia, estimated age-time patterns and sex difference are virtually unchanged by the dosimetry revision. The estimates of solid-cancer radiation risk per sievert and the curvilinear dose response for leukemia are both decreased by about 8% by the dosimetry revision, due to the increase in the gamma-ray dose estimates. The apparent shape of the dose response is virtually unchanged by the dosimetry revision, but for solid cancers, the additional 3 years of follow-up has some effect. In particular, there is for the first time a statistically significant upward curvature for solid cancer on the restricted dose range 0-2 Sv. However, the low-dose slope of a linear-quadratic fit to that dose range should probably not be relied on for risk estimation, since that is substantially smaller than the linear slopes on ranges 0-1 Sv, 0-0.5 Sv, and 0- 0.25 Sv. Although it was anticipated that the new dosimetry system might reduce some apparent dose overestimates for Nagasaki factory workers, this did not materialize, and factory workers have

  19. Autopsy findings of the first and second filial generations of atomic bomb survivors

    International Nuclear Information System (INIS)

    Autopsy findings of 652 fetuses whose parents or one parent were exposed to the Atomic Bomb (F1) and 115 fetuses which had one or two grandparents exposed (F2) were compared with that of 8570 fetuses whose parents were not exposed (control). The F1 fetuses have been collected since 1963 and F2 fetuses since 1971 voluntarily in Hiroshima. The findings were classified according to the types of delivery and to the distances away from the hypocenter where the parents and grandparents were exposed. Many normal cases in the group of artificial abortions and many malformations and pathological findings in the group of spontaneous abortions were found in both groups of F1 and F2. The malformations were cardiovascular, central nervous and urogenital system, quantitatively in that order, in both groups of F1 and F2. Although there were a few cases of cystic kidney and chondrodystrophy which belong to autosomal dominant and osteogenesis imperfecta which belong to autosomal recessive, these cases were not correlated with the distance. Most cases of malformation which belong to the multifactorial inheritance were found in each organ. No peculiar malformation was found in the groups of F1 and F2. (author)

  20. Mortality among the offspring (F1) of atomic bomb survivors, 1946-85.

    Science.gov (United States)

    Yoshimoto, Y; Schull, W J; Kato, H; Neel, J V

    1991-12-01

    We compare the mortality in the years 1946-85 in a cohort of 31,159 children born to parents one or both of whom were exposed to the atomic bombing of Hiroshima and Nagasaki (a parental gonadal dose greater than or equal to 0.01 Sv) with that in a control group of 41,069 children. The average gonadal dose for the exposed parents was 0.435 Sv. The mean age of the cohorts was 28.8 years. In the greater than or equal to 0.01 Sv dose group 1,253 deaths were observed in the subset of children both of whose parents have been assigned DS86 doses. 3.2% were attributed to cancers, 72.9% to all diseases except neoplasms. These proportions in the 0 Sv dose group were about the same. Based on a linear relative risk model, no statistically significant increase in the mortality attributable to diseases other than neoplasms is noted following parental exposure, the excess relative risk being 0.030 (+/- 0.046) per sievert based on the DS86 doses (RBE of neutrons = 20). For fatal cancer, no statistically significant effect of parental radiation dose was also observed. An analysis based on the full sample, using not only the DS86 dose group but also ad hoc dose group, yields essentially the same results as the analysis restricted to the DS86 dose group. PMID:1817186

  1. Changes of disease incidence among atomic-bomb survivors 1956-78

    International Nuclear Information System (INIS)

    Statistical observation was made concerning changes with time of incidences of various diseases in autopsy cases since 1956 when Atomic Bomb Hospital was established, and the following results were obtained. The incidence of lung cancer tended to increase in men and women of both groups (an exposed group and a non-exposed group). A marked decrease of the incidence of leukemia was recognized in men and women of both groups, and a decrease of that of malignant lymphoma was recognized in men. The incidence of liver cirrhosis and hepatic cancer tended to decrease in men and women of both groups. The incidence of colon cancer tended to increase in both groups, but that of stomach cancer decreased recently in men and women of both groups. Incidences of digestive organ diseases, cardiovascular diseases, cerebrovascular disorder, and respiratory organ diseases tended to increase in both groups, but urinary tract diseases, infectious diseases, and blood diseases tended to decrease in both groups, which suggested an increase of older persons' diseases due to aging of the exposed. Incidences of various diseases in the exposed changed almost in parallel with those in the non-exposed, and a difference in incidences of various diseases tended to be shortened. (Tsunoda, M.)

  2. Atomic Bomb and Leukemia : II. BIOLOGICAL EFFECTS

    OpenAIRE

    Ichimaru, Michito; Tomonaga, Masao; Amenomori, Tatsuhiko; Matsuo, Tatsuki

    1991-01-01

    Characteristic features of leukemia among atomic bomb survivors were studied. The ratio of a single leukemia type to all leukemias was highest for CML in Hiroshima, and the occurrence of CML was thought to be most characteristic for atomic bomb radiation induced leukemia. In the distribution of AML subtypes of FAR classification, there was no M3 cases in 1Gy or more group, although several atypical AML cases of survivors were observed. Chromosome study was conducted using colony forming cells...

  3. Agreement between death-certificate and autopsy diagnoses among atomic-bomb survivors

    International Nuclear Information System (INIS)

    Using the Atomic Bomb Casualty Commission/Radiation Effects Research Foundation series of over 5000 autopsies, we examined death-certificate accuracy for several disease categories and assessed the effect of potential modifying factors on this accuracy. For 12 cause-of-death categories, the overall percent agreement between death-certificate and autopsy diagnoses was only 52.5%. Although neoplasms had the highest detection rate (on the death certificate) in the study, still almost 25% of cancers diagnosed at autopsy were missed on the death certificate. Only for neoplasms and external causes of death were confirmation and detection rates above 70%. Confirmation rates were between 50% and 70% for infectious and parasitic diseases and heart and other vascular diseases. Detection rates reached a similar level for infectious and parasitic, cerebrovascular, and digestive diseases. Specificity rates were above 90% for all but the cerebrovascular disease category. Overall agreement decreased with increasing age of the decedents and was lower for deaths occurring outside of hospital vs those occurring in a hospital. There was some suggestion that agreement rates were higher for more-recent deaths but no indication that radiation dose, sex, city of residence, or inclusion in a biennial clinical-examination program influenced agreement. Because the inaccuracy of death-certificate diagnoses can have major implications for many aspects of health research and planning, it is important to be aware that death-certificate accuracy is low and can vary widely depending on the patient's age at death and the place of death. (J.P.N.)

  4. Systolic blood pressure and systolic hypertension in adolescence of atomic bomb survivors exposed in utero.

    Science.gov (United States)

    Nakashima, Eiji; Akahoshi, Masazumi; Neriishi, Kazuo; Fujiwara, Saeko

    2007-11-01

    Annual medical examinations were conducted during adolescence for the in utero clinical study sample subjects exposed prenatally to the atomic bombs in Hiroshima and Nagasaki. Systolic blood pressure and several anthropometric measurements were recorded during these examinations. For 1014 persons exposed in utero, two types of longitudinal analyses were performed, for a total of 7029 observations (6.93 observations per subject) of systolic blood pressure (continuous data) and systolic hypertension (binary data) for persons aged 9 to 19 years. Body mass index (BMI) and/or body weight were considered in the analyses as potential confounders. For the measurements of systolic blood pressure, the common dose effect was 2.09 mmHg per Gy and was significant (P = 0.017). The dose by trimester interaction was suggestive (P = 0.060). A significant radiation dose effect was found in the second trimester (P = 0.001), with an estimated 4.17 mmHg per Gy, but in the first and third trimesters, radiation dose effects were not significant (P > 0.50). For prevalence of systolic hypertension, the radiation dose effect was significant (P = 0.009); the odds ratio at 1 Gy was 2.23 [95% confidence interval (CI): 1.23, 4.04], and the dose by trimester interaction was not significant (P = 0.778). The dose response of systolic hypertension had no dose threshold, with a threshold point estimate of 0 Gy (95% CI: <0.0, 1.1 Gy). The dose response for systolic blood pressure was most pronounced in the second trimester, the most active organogenesis period for the organs relevant to blood pressure. PMID:17973553

  5. The effect of changes in dosimetry on cancer mortality risk estimates in the atomic bomb survivors

    International Nuclear Information System (INIS)

    In the spring of 1986, RERF received a new dosimetry system which was developed by the US-Japan Committee for Reassessment of Atomic Bomb Radiation Dosimetry in Hiroshima and Nagasaki. This report presents the comparisons of leukemia and nonleukemia cancer mortality risk estimates under the old and new dosimetries. In terms of total kerma (essentially whole-body gamma-ray plus neutron exposure), the risk estimates for both types of cancer are 75 %-85 % higher with the new dosimetry. This and other summary comparisons here make some allowance for possible nonlinearity at high estimated doses. It is also important to consider the changes in relation to organ doses and assumptions about the relative biological effectiveness (RBE) of neutrons. Without regard to RBE, the risk estimates for total organ dose are essentially unchanged by the dosimetry revision. However, with increasing assumed values of RBE, the estimated low-LET risk decreases much less rapidly under the new dosimetry, due to the smaller neutron component. Thus at an assumed constant RBE of 10, for example, the effect of the dosimetry revision is to increase organ dose risk estimates, relative to those based on the old dosimetry, by 30 % for nonleukemia and 80 % for leukemia. At an RBE of 20 these increases are 72 % and 136 %, respectively. A number of other issues are discussed. The city difference in dose-response is smaller with the new dosimetry, and is no longer statistically significant, even at an RBE of one. Estimation of RBE is even less feasible with the new dosimetry. There is substantial question of the linearity in dose-response, in the sense of a leveling off at higher doses. Finally, some indication is given of how estimated lifetime risks from this dosimetry may compare to widely-used estimates based largely on the RERF data with the previous dosimetry. (author)

  6. Comparison of medical data of atomic-bomb survivors resident in the U.S. and Hiroshima

    International Nuclear Information System (INIS)

    The third medical examination of A-bomb survivors residing in the U.S. was performed in San Francisco, Los Angeles, Seattle and Honolulu during the period 6 - 28 May 1981. The test results were studied and the actual state of the survivors in the U.S., was reviewed as explained hereunder. 1) The number of survivors actually registered with the Committee of A-bomb Survivors in the U.S. is 491 (133 males and 358 females) of whom 57.2% are U.S. citizens. Those exposed in Hiroshima accounted for 91.8%. The mean age was 53.3 +- 8.9, thus they were more than 3 years younger than their counterparts in Hiroshima. The present addresses of the survivors are distributed over 15 states, but those in California constitute 77.6% of the total, and when those residing in the states along the west coast and Hawaii are added the rate increases to 95.9%. 2) Those who underwent health examination numbered 166 (45 males and 121 females), and comparison of the U.S. survivors against the Hiroshima survivors showed there to be a difference in the following points. The prevalence of hypertension was lower among the U.S. survivors, but RBC counts and hemoglobin concentration were significantly higher. The same was observed for blood lipids with hypercholesterolemia and hypertriglyceridemia being found at a significantly higher rate in the U.S. survivors. 3) Those free of clinical abnormalities in this survey were 37.3%, and the rest required dietary guidance, follow-up observation, detailed examination of treatment. Those with diseases which are considered would make them eligible for health management allowance if in Japan, accounted for 18.7%. (author)

  7. Frequency of malignant tumors during the first two decades of life in the offspring (F1) of atomic bomb survivors

    International Nuclear Information System (INIS)

    The incidence of cancer prior to age 20 has been determined in children born to atomic bomb survivors and to a suitable comparison group. Tumor ascertainment was through death certificates and the tumor registries maintained in Hiroshima and Nagasaki. The rationale for the study stemmed from the evidence that a significant proportion of childhood tumors such as retinoblastoma and Wilms' tumor arise on the basis of a mutant gene inherited from one parent plus a second somatic cell mutation involving the allele of this gene. Gonadal radiation doses were calculated using the recently established DS86 system, supplemented by an ad hoc system for those children whose parents' (one or both) DS86 dose could not be computed but for whom a dose could be developed on the basis of the available information. The total data set consisted of: 1) a cohort of 31,150 liveborn children, one or both of whose parents received ≥ 0.01 Sv of radiation at the time of the A-bombings (an average conjoint gonad exposure of 0.435 Sv), and 2) two suitable comparison groups, totaling 41,066 children. A total of 92 cancer cases at age less than 20 years was confirmed; 49 and 43 cases, respectively, in the 0 Sv and ≥ 0.01 Sv groups. A multiple linear regression analysis revealed no increase in malignancy in the children of exposed parents. However, examination of the data suggested that only 3.0 % to 5.0 % of the tumors of childhood observed in the comparison groups are associated with an inherited genetic predisposition that would be expected to exhibit an altered frequency if the parental mutation rate were increased. These is thus far no confirmation of the positive findings of Nomura in a mouse system. (author)

  8. Mortality among the offspring (F1) of atomic bomb survivors, 1946-85

    International Nuclear Information System (INIS)

    We compare deaths occurring in the years 1946-85 in a cohort of 31,159 children born to parents one or both of whom were exposed to the atomic bombing of Hiroshima or Nagasaki, and received a combined (i.e., joint) gonadal dose of 0.01 Sv or more, with deaths in a comparable control group, totaling 41,069 children. The average combined gonadal dose equivalent for the exposed parents was 0.435 Sv. Gonadal doses were calculated using the recently established DS86 system, supplemented by an ad hoc system for those children for whom a DS86 dose could not be computed for one or both parents. The mean age of living members of the cohorts was 28.8 years. When a linear relative risk model is fitted to the data, no statistically significant increase in the risk of mortality attributable to diseases other than neoplasms is noted following parental exposure, the excess relative risk being 0.030 (±0.046) per sievert based on the subset of individuals with DS86 doses, assuming the RBE of neutrons to be 20. For fatal cancer, in confirmation of an earlier report on cancer incidence below the age of 20 in this same group, again no statistically significant effect was observed as parental radiation dose increased. This model was also fitted to the data used in the relative risk estimate to provide some continuity with the past. The results give an intercept of 0.0420(±0.0015) and a linear regression coefficient of 0.00169 (±0.00157) per sievert. This leads to the calculation of a (statistically nonsignificant) excess relative risk of 0.040, in good agreement with the excess obtained by fitting the relative risk model. An analysis based on the full sample, using not only the DS86 dose group but also the ad hoc dose group, yields essentially the same result as the analysis restricted to the DS86 dose group. (J.P.N.)

  9. Incidence of leukemia among atomic bomb survivors in relation to neutron and gamma dose, Hiroshima and Nagasaki, 1950-71

    International Nuclear Information System (INIS)

    The incidence of leukemia during 1950-71 in the fixed mortality sample of atomic bomb survivors in Hiroshima and Nagasaki has been analyzed as a function of individual gamma and neutron kerma and marrow dose. Two dose response models were tested for each of acute leukemia, chronic granulocytic leukemia, and all types of leukemia, respectively. Each model postulates that leukemia incidence depends upon the sum of the separate risks imposed by the gamma ray and neutron doses; in Model I both are assumed to be directly proportional to the respective doses, while Model II assumes that while the risk from neutrons is directly proportional to the dose, the risk from gamma rays is proportional to dose-squared. Weighted regression analyses were performed for each model. When the two models were fitted to the data for all types of leukemia, the estimated regression coefficients corresponding to the neutron and gamma ray doses both differed significantly from zero, for each model. However, when analysis was restricted to acute leukemia, both the neutron and gamma ray coefficients were significant only for Model II, and with respect to chronic granulocytic leukemia, only the coefficient of the neutron dose was significant, using either Model I or Model II. It appeared that the responses of the two leukemia types differed by type of radiation. If the chronic granulocytic and acute leukemias are considered together, the Model II appears to fit the data slightly better than Model I, but neither models is rejected by the data. (author)

  10. Inverse associations between obesity indicators and thymic T-cell production levels in aging atomic-bomb survivors.

    Science.gov (United States)

    Yoshida, Kengo; Nakashima, Eiji; Kubo, Yoshiko; Yamaoka, Mika; Kajimura, Junko; Kyoizumi, Seishi; Hayashi, Tomonori; Ohishi, Waka; Kusunoki, Yoichiro

    2014-01-01

    Reduction of the naive T-cell population represents a deteriorating state in the immune system that occurs with advancing age. In animal model studies, obesity compromises the T-cell immune system as a result of enhanced adipogenesis in primary lymphoid organs and systemic inflammation. In this study, to test the hypothesis that obesity may contribute to the aging of human T-cell immunity, a thousand atomic-bomb survivors were examined for obesity status and ability to produce naive T cells, i.e., T-cell receptor excision circle (TREC) numbers in CD4 and CD8 T cells. The number of TRECs showed a strong positive correlation with naive T cell numbers, and lower TREC numbers were associated with higher age. We found that the TREC number was inversely associated with levels of obesity indicators (BMI, hemoglobin A1c) and serum CRP levels. Development of type-2 diabetes and fatty liver was also associated with lower TREC numbers. This population study suggests that obesity with enhanced inflammation is involved in aging of the human T-cell immune system. Given the fact that obesity increases the risk of numerous age-related diseases, attenuated immune competence is a possible mechanistic link between obesity and disease development among the elderly. PMID:24651652

  11. Report on the result of the eighth medical examination of atomic bomb survivors in the South America

    Energy Technology Data Exchange (ETDEWEB)

    Ohta, Michiya [Hiroshima Red Cross Hospital (Japan); Ishioka, Shinichi; Hayakawa, Tohru; Kawano, Michimura; Sasaki, Yoshioki; Hirakami, Kojiro

    1999-05-01

    The atomic bomb survivors emigrating in the South America were 189 in total (160 in Brazil, 4 in Paraguay, 8 in Bolivia, 14 in Argentina and 3 in Peru) in November, 1998. Ninety-three persons (49%) took a medical examination (72 in Brazil, 3 in Paraguay, 6 in Bolivia, 9 in Argentina and 3 in Peru). The mean age was 68.6 years in male, and 68.1 years in female. They had hypertension (21.5%), diabetes (8.6%), cancer (6.5%), heart disease (5.4%), and thyroid gland diseases (4.3%). The subjective symptoms with high frequency were complete exhaustion or fatigue (58.1%), loss of vigor (55.9%), heat intolerance (49.5%) and numbness or tingling (47.1%). Electrocardiogram abnormality, total protein decrement, hypercholesterolemia and corpulence were almost the same as the last time. There was no change of a ratio of persons who needed tests on treatments. (K.H.)

  12. Report on the result of the eighth medical examination of atomic bomb survivors in the South America

    International Nuclear Information System (INIS)

    The atomic bomb survivors emigrating in the South America were 189 in total (160 in Brazil, 4 in Paraguay, 8 in Bolivia, 14 in Argentina and 3 in Peru) in November, 1998. Ninety-three persons (49%) took a medical examination (72 in Brazil, 3 in Paraguay, 6 in Bolivia, 9 in Argentina and 3 in Peru). The mean age was 68.6 years in male, and 68.1 years in female. They had hypertension (21.5%), diabetes (8.6%), cancer (6.5%), heart disease (5.4%), and thyroid gland diseases (4.3%). The subjective symptoms with high frequency were complete exhaustion or fatigue (58.1%), loss of vigor (55.9%), heat intolerance (49.5%) and numbness or tingling (47.1%). Electrocardiogram abnormality, total protein decrement, hypercholesterolemia and corpulence were almost the same as the last time. There was no change of a ratio of persons who needed tests on treatments. (K.H.)

  13. Inverse associations between obesity indicators and thymic T-cell production levels in aging atomic-bomb survivors.

    Directory of Open Access Journals (Sweden)

    Kengo Yoshida

    Full Text Available Reduction of the naive T-cell population represents a deteriorating state in the immune system that occurs with advancing age. In animal model studies, obesity compromises the T-cell immune system as a result of enhanced adipogenesis in primary lymphoid organs and systemic inflammation. In this study, to test the hypothesis that obesity may contribute to the aging of human T-cell immunity, a thousand atomic-bomb survivors were examined for obesity status and ability to produce naive T cells, i.e., T-cell receptor excision circle (TREC numbers in CD4 and CD8 T cells. The number of TRECs showed a strong positive correlation with naive T cell numbers, and lower TREC numbers were associated with higher age. We found that the TREC number was inversely associated with levels of obesity indicators (BMI, hemoglobin A1c and serum CRP levels. Development of type-2 diabetes and fatty liver was also associated with lower TREC numbers. This population study suggests that obesity with enhanced inflammation is involved in aging of the human T-cell immune system. Given the fact that obesity increases the risk of numerous age-related diseases, attenuated immune competence is a possible mechanistic link between obesity and disease development among the elderly.

  14. Radiation-related small head sizes among prenatally exposed atomic bomb survivors

    International Nuclear Information System (INIS)

    The population prenatally exposed to the atomic bombings of Hiroshima and Nagasaki, referred to as the In Utero Clinical Sample, on whom Dosimetry System 1986 doses are available consists of 1566 individuals (1242 in Hiroshima and 324 in Nagasaki). Of these study subjects, 1473 had the circumference of their heads measured at least once between ages 9 to 19. Among these 1473 individuals, 62 had small heads - the circumference of the head was two standard deviations or more below the observed specific age-at-measurement mean. Twenty-six of the 30 cases with severe mental retardation described elsewhere are included among these subjects. Of these 26 severely mentally retarded cases, 15 (58%) had small heads. Most (86%) of the individuals with small heads were exposed in the first or second trimester of pregnancy - 55% in the former period and 31% in the latter. Various dose-response relationships, with and without a threshold, have been fitted to the data grouped by the trimester or postovulatory age (weeks after ovulation) at which exposure occurred. A significant effect of radiation on the frequency of individuals with atypically small heads is observed only in the first and second trimesters and for the intervals postovulation of 0-7 weeks and 8-15 weeks. Although the risk of a small head at 0-7 weeks postovulation increases significantly with increasing dose, no increase in risk for severe mental retardation is noted in this period. No excess risk of a small head was seen in the third trimester or among individuals exposed at ≥ 16 weeks postovulation. The estimated threshold, based either on a linear or a linear-quadratic dose-response relationship, is zero or thereabouts. This apparent absence of a threshold and the somewhat different periods of vulnerability suggest an embryological difference in the development of both a small head and mental retardation. Mean IQ (using the Koga test) and its standard deviation are 63.8 and 8.5, respectively, for the

  15. Report of a workshop on the application of molecular genetics to the study of mutation in the children of atomic-bomb survivors

    International Nuclear Information System (INIS)

    A workshop, entitled 'application of molecular genetics to the study of mutation in the children of atomic-bomb survivors,' was held on November 12-14, 1991, which was presided over by Mortimer Mendelsohn and Toshiyuki Kumatori, co-chairmen of the RERF Scientific Council. The purpose of this workshop was to evaluate the status of the emerging DNA-oriented techniques for the study of mutation and to discuss possible developments that would bear upon the program. Although specific genetic follow-up studies of children of A-bomb survivors were addressed, it was clear to the participants that their discussions had much-wider implications -- most notably, the Chernobyl accidents of 1986. This report summarizes the contents of the lively 2.5-day meeting. A complete list of the invited participants is shown in the Appendix. (N.K.) 79 refs

  16. A method for analysis of cancer incidence in atomic bomb survivors, with application to acute leukemia

    International Nuclear Information System (INIS)

    Some statistical methodology developed for the analysis of the effect of radiation on cancer incidence is described. The methods presented make use of grouped data for estimation of and testing hypotheses about temporal aspects of the radiogenic effects on cancer incidence. The suggested approach is reviewed by its application to recent data on acute leukemia incidence in the RERF Life Span Study sample. The results of these analyses suggest that, although the temporal pattern of the radiogenic excess differs markedly by age at the time of the bomb (ATB), there is no statistically significant evidence of differences in total excess leukemia by age ATB throughout the study period. (author)

  17. Studies of the mortality of atomic bomb survivors, Report 14, 1950-2003: an overview of cancer and noncancer diseases.

    Science.gov (United States)

    Ozasa, Kotaro; Shimizu, Yukiko; Suyama, Akihiko; Kasagi, Fumiyoshi; Soda, Midori; Grant, Eric J; Sakata, Ritsu; Sugiyama, Hiromi; Kodama, Kazunori

    2012-03-01

    This is the 14th report in a series of periodic general reports on mortality in the Life Span Study (LSS) cohort of atomic bomb survivors followed by the Radiation Effects Research Foundation to investigate the late health effects of the radiation from the atomic bombs. During the period 1950-2003, 58% of the 86,611 LSS cohort members with DS02 dose estimates have died. The 6 years of additional follow-up since the previous report provide substantially more information at longer periods after radiation exposure (17% more cancer deaths), especially among those under age 10 at exposure (58% more deaths). Poisson regression methods were used to investigate the magnitude of the radiation-associated risks, the shape of the dose response, and effect modification by gender, age at exposure, and attained age. The risk of all causes of death was positively associated with radiation dose. Importantly, for solid cancers the additive radiation risk (i.e., excess cancer cases per 10(4) person-years per Gy) continues to increase throughout life with a linear dose-response relationship. The sex-averaged excess relative risk per Gy was 0.42 [95% confidence interval (CI): 0.32, 0.53] for all solid cancer at age 70 years after exposure at age 30 based on a linear model. The risk increased by about 29% per decade decrease in age at exposure (95% CI: 17%, 41%). The estimated lowest dose range with a significant ERR for all solid cancer was 0 to 0.20 Gy, and a formal dose-threshold analysis indicated no threshold; i.e., zero dose was the best estimate of the threshold. The risk of cancer mortality increased significantly for most major sites, including stomach, lung, liver, colon, breast, gallbladder, esophagus, bladder and ovary, whereas rectum, pancreas, uterus, prostate and kidney parenchyma did not have significantly increased risks. An increased risk of non-neoplastic diseases including the circulatory, respiratory and digestive systems was observed, but whether these are causal

  18. Korean atomic bomb victims.

    Science.gov (United States)

    Sasamoto, Yukuo

    2009-01-01

    After colonizing Korea, Japan invaded China, and subsequently initiated the Pacific War against the United States, Britain, and their allies. Towards the end of the war, U.S. warplanes dropped atomic bombs on Hiroshima and Nagasaki, which resulted in a large number of Koreans who lived in Hiroshima and Nagasaki suffering from the effects of the bombs. The objective of this paper is to examine the history of Korea atomic bomb victims who were caught in between the U.S., Japan, the Republic of Korea (South Korea) and the Democratic People's Republic of Korea (North Korea). PMID:20521424

  19. Radiation May Indirectly Impair Growth Resulting in Reduced Standing Height via Subclinical Inflammation in Atomic-Bomb Survivors Exposed at Young Ages

    Directory of Open Access Journals (Sweden)

    Eiji Nakashima

    2015-01-01

    Full Text Available For young atomic-bomb (A-bomb survivors, A-bomb radiation’s (total effect on standing height is thought to comprise the sum of direct effect and indirect effect via inflammation. With the data of five inflammatory markers—white blood cell count, sialic acid, corrected erythrocyte sedimentation rate (ESR, α1 globulin, and α2 globulin—obtained in adulthood during the period 1988 to 1992, a summary inflammatory index was constructed as a surrogate for the five subclinical inflammatory markers. For 3,327 A-bomb survivors exposed at ages of less than 25 years, a structural equation model was analyzed to measure direct radiation effects on adult height as well as mediating effect of radiation via inflammation on the height after adjustment for other risk factors, smoking, cancer, inflammatory disease, obesity, and diabetes mellitus. The mediation proportion of the radiation effect on height via inflammation was approximately 5% for both sexes for all ages, and indirect dose effects via inflammation were statistically significant for both sexes combined and for females exposed at ages 0 to 5 years. Indirect dose effects for all ages via sialic acid, corrected ESR, and α2 globulin were marginally significant for both sexes combined and for females. These proportions are likely underestimated.

  20. Long-term epidemiological studies of atomic bomb survivors in Hiroshima and Nagasaki: study populations, dosimetry and summary of health effects.

    Science.gov (United States)

    Okubo, Toshiteru

    2012-10-01

    The Radiation Effects Research Foundation succeeded 28 years' worth of activities of the Atomic Bomb Casualty Commission on long-term epidemiological studies in Hiroshima and Nagasaki. It has three major cohorts of atomic bomb survivors, i.e. the Life Span Study (LSS) of 120,000 people, the In Utero Cohort of 3600 and the Second Generation Study (F(1)) of 77,000. The LSS and F(1) studies include a periodic health examination for each sub-cohort, i.e. the Adult Health Study and the F(1) Clinical Study, respectively. An extensive individual dose estimation was conducted and the system was published as the Dosimetry System established in 2002 (DS02). As results of these studies, increases of cancers in relation to dose were clearly shown. Increases of other mortality causes were also observed, including heart and respiratory diseases. There has been no evidence of genetic effects in the survivors' children, including cancer and other multi-factorial diseases. The increase in the expected mortality number in the next 10 y would allow the analyses of further details of the observed effects related to atomic bomb exposures. PMID:22908354

  1. Rearranged anaplastic lymphoma kinase (ALK) gene found for the first time in adult-onset papillary thyroid cancer cases among atomic bomb survivors

    Energy Technology Data Exchange (ETDEWEB)

    Hamatani, K.; Mukai, M.; Takahashi, K.; Nakachi, K.; Kusunoki, Y. [Radiobiology/Molecular Epidemiology, Radiation Effects Research Foundation, Hiroshima (Japan); Hayashi, Y. [Geriatric Health Service Facility Hidamari, Hiroshima (Japan)

    2012-07-01

    Full text of the publication follows: Thyroid cancer is one of the malignancies most strongly associated with ionizing radiation in humans. Epidemiology studies of atomic bomb (A-bomb) survivors have indicated that excess relative risk of papillary thyroid cancer per Gy was remarkably high in the survivors. We therefore aim to clarify mechanisms linking A-bomb radiation exposure and development of papillary thyroid cancer. Toward this end, we intend to clarify characteristics of gene alterations occurring in radiation-associated adult-onset papillary thyroid cancer from the Life Span Study cohort of A-bomb survivors. We have thus far found that with increased radiation dose, papillary thyroid cancer cases with chromosomal rearrangements (mainly RET/PTC rearrangements) significantly increased and papillary thyroid cancer cases with point mutations (mainly BRAF-V600E) significantly decreased. Papillary thyroid cancer cases with non-detected gene alterations that carried no mutations in RET, NTRK1, BRAF or RAS genes tended to increase with increased radiation dose. In addition, we found that relative frequency of these papillary thyroid cancer cases significantly decreased with time elapsed since exposure. Through analysis of papillary thyroid cancer cases with non-detected gene alterations, we recently discovered a new type of rearrangement for the first time in papillary thyroid cancer, i.e., rearranged anaplastic lymphoma kinase (ALK) gene, although identification of any partner gene(s) is needed. Specifically, rearrangement of ALK was found in 10 of 19 exposed papillary thyroid cancer cases with non-detected gene alterations but not in any of the six non-exposed papillary thyroid cancer cases. Furthermore, papillary thyroid cancer with ALK rearrangement was frequently found in the cases with high radiation dose or with short time elapsed since A-bomb exposure. These results suggest that chromosomal rearrangement, typically of RET and ALK, may play an important

  2. Relationship between spontaneous γH2AX foci formation and progenitor functions in circulating hematopoietic stem and progenitor cells among atomic-bomb survivors.

    Science.gov (United States)

    Kajimura, Junko; Kyoizumi, Seishi; Kubo, Yoshiko; Misumi, Munechika; Yoshida, Kengo; Hayashi, Tomonori; Imai, Kazue; Ohishi, Waka; Nakachi, Kei; Weng, Nan-Ping; Young, Lauren F; Shieh, Jae-Hung; Moore, Malcolm A; van den Brink, Marcel R M; Kusunoki, Yoichiro

    2016-05-01

    Accumulated DNA damage in hematopoietic stem cells is a primary mechanism of aging-associated dysfunction in human hematopoiesis. About 70 years ago, atomic-bomb (A-bomb) radiation induced DNA damage and functional decreases in the hematopoietic system of A-bomb survivors in a radiation dose-dependent manner. The peripheral blood cell populations then recovered to a normal range, but accompanying cells derived from hematopoietic stem cells still remain that bear molecular changes possibly caused by past radiation exposure and aging. In the present study, we evaluated radiation-related changes in the frequency of phosphorylated (Ser-139) H2AX (γH2AX) foci formation in circulating CD34-positive/lineage marker-negative (CD34+Lin-) hematopoietic stem and progenitor cells (HSPCs) among 226Hiroshima A-bomb survivors. An association between the frequency of γH2AX foci formation in HSPCs and the radiation dose was observed, but the γH2AX foci frequency was not significantly elevated by past radiation. We found a negative correlation between the frequency of γH2AX foci formation and the length of granulocyte telomeres. A negative interaction effect between the radiation dose and the frequency of γH2AX foci was suggested in a proportion of a subset of HSPCs as assessed by the cobblestone area-forming cell assay (CAFC), indicating that the self-renewability of HSPCs may decrease in survivors who were exposed to a higher radiation dose and who had more DNA damage in their HSPCs. Thus, although many years after radiation exposure and with advancing age, the effect of DNA damage on the self-renewability of HSPCs may be modified by A-bomb radiation exposure. PMID:27169377

  3. Dose-responses from multi-model inference for the non-cancer disease mortality of atomic bomb survivors.

    Science.gov (United States)

    Schöllnberger, H; Kaiser, J C; Jacob, P; Walsh, L

    2012-05-01

    The non-cancer mortality data for cerebrovascular disease (CVD) and cardiovascular diseases from Report 13 on the atomic bomb survivors published by the Radiation Effects Research Foundation were analysed to investigate the dose-response for the influence of radiation on these detrimental health effects. Various parametric and categorical models (such as linear-no-threshold (LNT) and a number of threshold and step models) were analysed with a statistical selection protocol that rated the model description of the data. Instead of applying the usual approach of identifying one preferred model for each data set, a set of plausible models was applied, and a sub-set of non-nested models was identified that all fitted the data about equally well. Subsequently, this sub-set of non-nested models was used to perform multi-model inference (MMI), an innovative method of mathematically combining different models to allow risk estimates to be based on several plausible dose-response models rather than just relying on a single model of choice. This procedure thereby produces more reliable risk estimates based on a more comprehensive appraisal of model uncertainties. For CVD, MMI yielded a weak dose-response (with a risk estimate of about one-third of the LNT model) below a step at 0.6 Gy and a stronger dose-response at higher doses. The calculated risk estimates are consistent with zero risk below this threshold-dose. For mortalities related to cardiovascular diseases, an LNT-type dose-response was found with risk estimates consistent with zero risk below 2.2 Gy based on 90% confidence intervals. The MMI approach described here resolves a dilemma in practical radiation protection when one is forced to select between models with profoundly different dose-responses for risk estimates. PMID:22437350

  4. Brain abnormalities among the mentally retarded prenatally exposed atomic bomb survivors

    International Nuclear Information System (INIS)

    An increased occurrence of severe mental retardation, with or without accompanying small head size, at specific gestational ages has been the most conspicuous effect on brain development of prenatal exposure to the bombings of Hiroshima and Nagasaki. A variety of biological mechanisms could be responsible for this finding, including cell killing and mismanaged neuronal migration. We describe here the findings on magnetic resonance imaging of the brains of five of these mentally retarded individuals, all of whom were exposed in the 8th through the 15th weeks following fertilization, the gestational period shown to be the most vulnerable to radiation-related damage. In the two cases exposed at the 8th or 9th week following fertilization, large areas of ectopic gray matter are seen, strong evidence of a failure of the neurons to migrate to their proper functional sites. The two individuals exposed in the 12th or 13th week show no readily recognized ectopic gray areas but do show mild macrogyria, which implies some impairment in the development of the cortical zone. Moreover, both have mega cisterna magna. Finally, the one individual seen who was exposed still later in development, in the 15th week, shows none of the changes seen in the other four individuals. This person's brain, though small, appears to have normal architecture. These findings are discussed in terms of the embryological events transpiring at the time of the prenatal exposure of these individuals to ionizing radiation. (author)

  5. The Atomic Bomb Casualty Commission in retrospect

    OpenAIRE

    Putnam, Frank W.

    1998-01-01

    For 50 years, the Atomic Bomb Casualty Commission (ABCC) and its successor, the Radiation Effects Research Foundation (RERF), have conducted epidemiological and genetic studies of the survivors of the atomic bombs and of their children. This research program has provided the primary basis for radiation health standards. Both ABCC (1947–1975) and RERF (1975 to date) have been a joint enterprise of the United States (through the National Academy of Sciences) and of J...

  6. A longitudinal study of growth and development among prenatally exposed atomic-bomb survivors

    International Nuclear Information System (INIS)

    Growth retardation due to A-bomb exposure has been evaluated for 455 individuals with nine repeated measurements of stature at age 10-18 yr using growth curve analysis and either two covariates, Dosimetry System 1986 (DS86) uterine absorbed dose and postovulatory age (weeks), or three covariates, DS86 uterine dose, DS86 uterine dose squared, and postovulatory age. Of the several comparisons made by city, sex, DS86 dose, and postovulatory age, the largest significant difference was found. However, on the basis of a linear-quadratic (L-Q) dose response, no significant difference was found. A highly significant growth retardation due to DS86 uterine absorbed dose was observed for all trimesters combined and for the first and second trimesters. In the first trimester, all parameter estimates based on a linear (L) or L-Q dose-response relationship were negative in relation to DS86 uterine absorbed dose. The parameter estimates in the second trimester were negative for a constant term and positive for an L or L-Q term. Radiation-related growth retardation at age 10-18 yr is clearly evident. The dose effect in the third trimester was not significant with either the L or the L-Q model. A growth analysis, based on an L dose-response relationship, was made for 704 and 838 children with four repeated measurements of stature from ages 10-13 and 15-18 yr, respectively. The retardation effect is clearly evident at age 10-13 and continues at age 15-18. Growth retardation in age 10-13 was highly significant for all trimesters combined but suggestive only for the first trimester. The group age 15-18 revealed a highly significant growth retardation for both the first and second trimesters. The relationship between birth weights and repeated measurements of stature in adolescence was discussed on the basis of the results obtained by a growth curve analysis. (J.P.N.)

  7. Long-term radiation-related health effects in a unique human population: lessons learned from the atomic bomb survivors of Hiroshima and Nagasaki.

    Science.gov (United States)

    Douple, Evan B; Mabuchi, Kiyohiko; Cullings, Harry M; Preston, Dale L; Kodama, Kazunori; Shimizu, Yukiko; Fujiwara, Saeko; Shore, Roy E

    2011-03-01

    For 63 years scientists in the Atomic Bomb Casualty Commission and its successor, the Radiation Effects Research Foundation, have been assessing the long-term health effects in the survivors of the atomic bombings of Hiroshima and Nagasaki and in their children. The identification and follow-up of a large population (approximately a total of 200,000, of whom more than 40% are alive today) that includes a broad range of ages and radiation exposure doses, and healthy representatives of both sexes; establishment of well-defined cohorts whose members have been studied longitudinally, including some with biennial health examinations and a high survivor-participation rate; and careful reconstructions of individual radiation doses have resulted in reliable excess relative risk estimates for radiation-related health effects, including cancer and noncancer effects in humans, for the benefit of the survivors and for all humankind. This article reviews those risk estimates and summarizes what has been learned from this historic and unique study. PMID:21402804

  8. Report on results of third medical examination of Atomic Bomb Survivors residing in the U.S

    International Nuclear Information System (INIS)

    The number of survivors actually registered with the Committee of A-bomb survivors in the U.S. in 491 (133 males and 358 females) of whom 57.3% are U.S. citizens. Those exposed in Hiroshima accounted for 91.8%. The mean age was 53.3 +- 8.9, thus they were more than 3 years younger than their counterparts in Hiroshima. Responses to the Health Survey Questionnaires numbered 255, and those with symptoms which appeared to be related to diseases were found at a high rate among the early entrants, but as the number of those receiving examination in this group was few, it is considered that many of those in poor health had come in for the examination. No association could be demonstrated between psychological complaints and exposure status. Those who underwent health examination numbered 166 (45 males and 121 females), and comparison of the U.S. survivors against the Hiroshima survivors showed there to be a difference in the following points. The prevalence of hypertension was lower among the U.S. survivors, but RBC counts and hemoglobin values were significantly higher. The same was observed for blood lipids with hypercholesterolemia and hypertriglyceridemia being found at a significantly higher rate in the U.S. survivors, the cause being considered to be the larger intake of animal fat and sugar by those of Japanese ancestry than the indigenous Japanese. Those free of clinical abnormalities in this survey were 37.3%, and the rest required dietary guidance, follow-up observation, detailed examination or treatment. Those with diseases which are considered would make them eligible for health management allowance if in Japan, accounted for 18.7%. (J.P.N.)

  9. Leukemia incidence among individuals exposed in utero, children of atomic bomb survivors, and their controls; Hiroshima and Nagasaki, 1945-79

    International Nuclear Information System (INIS)

    The incidence of leukemia has been analyzed in relation to the fetal dose of individuals exposed in utero, and the parental gonadal dose of individuals born to atomic bomb survivors and controls in the two fixed RERF cohorts. Among 3,636 in utero exposed children and controls, 3 leukemia cases have been identified through 1979. No excess risk of leukemia for in utero exposed children is apparent. For children born to exposed parents and controls, 36 leukemia cases have been identified in the years 1946-79 among 50,689 study subjects where the parental gonadal dose is available. Again, no excess risk of leukemia exists. (author)

  10. A prospective follow-up study of the association of radiation exposure with fatal and non-fatal stroke among atomic bomb survivors in Hiroshima and Nagasaki (1980–2003)

    OpenAIRE

    Takahashi, Ikuno; Abbott, Robert D; Ohshita, Tomohiko; Takahashi, Tetsuya; Ozasa, Kotaro; Akahoshi, Masazumi; Fujiwara, Saeko; Kodama, Kazunori; Matsumoto, Masayasu

    2012-01-01

    Objective Use of medical radiotherapy has increased markedly in recent decades. Whether the consequence includes an increased risk of cardiovascular disease remains to be determined. The purpose of this study was to examine the association between radiation exposure and the incidence of stroke among Japanese atomic bomb survivors. Design A prospective follow-up study. Setting and participants Radiation exposure from the atomic bombing was assessed in 9515 subjects (34.8% men) with 24-year fol...

  11. Report on the results of the eleventh medical examination of atomic bomb survivors resident in North America

    Energy Technology Data Exchange (ETDEWEB)

    Yamakido, Michio [Hiroshima Univ. (Japan). School of Medicine; Dohy, Hiroo; Neriishi, Kazuo [and others

    1998-01-01

    The 11th medical examination of A-bomb survivors was conducted in 1997. Two medical teams conducted health examinations in Los Angeles and Seattle, and in San Francisco and Hawaii, respectively. The total number of A-bomb survivors resident in North America as of the end of July 1997 was 1,060, an increase of 17 over that confirmed in 1995. The number of survivors exposed <2,000-m from the hypocenter was 234, accounting for 22.1% of the total. The confirmed number of in-utero exposed survivors was 26. As to the past medical history information, breast cancer, thyroid cancer, and heart disease were frequently observed in the <2,000-m group. Frequent subjective symptoms include complete exhaustion or fatigue, loss of vigor, blurring of vision, itching of the skin, which were reported in more than 40% of the survivors. The frequencies of nocturia, nervousness, severe headache, and excessive sweating in cold weather were higher in the <2,000-m group. Chest pain was seen frequently in the <2,000-m group for males, but no difference was observed in females. Nocturia was observed in more than half of the males in the <2,000-m group. There were 99 cases (22.8%) with fasting plasma glucose level of 110 mg/dl or above, consisting of 39 males (32.0%) and 60 females (19.2%). Abnormal HbA1c levels were observed in 33 cases (7.6%), including 12 males (9.8%) and 11 females (6.7%). The proportion of cases with abnormal HbA1c levels was higher in males. No difference by exposure status was observed either for fasting plasma glucose or HbA1c. The disease of the highest prevalence was hyperlipidemia (57.4%), followed by hypertension (35.0%), obesity (27.2%), liver disease (21.9%), thyroid disease (20.0%), gastrointestinal disease (20.7%), heart disease (13.4%) and urological disease (12.9%). Malignant tumors were observed in two cases in L.A., two in Seattle, and one in S.F. Cancer will be important issue in the future examinations. (K.H.)

  12. Investigation on circular asymmetry of geographical distribution in cancer mortality of Hiroshima atomic bomb survivors based on risk maps: analysis of spatial survival data.

    Science.gov (United States)

    Tonda, Tetsuji; Satoh, Kenichi; Otani, Keiko; Sato, Yuya; Maruyama, Hirofumi; Kawakami, Hideshi; Tashiro, Satoshi; Hoshi, Masaharu; Ohtaki, Megu

    2012-05-01

    While there is a considerable number of studies on the relationship between the risk of disease or death and direct exposure from the atomic bomb in Hiroshima, the risk for indirect exposure caused by residual radioactivity has not yet been fully evaluated. One of the reasons is that risk assessments have utilized estimated radiation doses, but that it is difficult to estimate indirect exposure. To evaluate risks for other causes, including indirect radiation exposure, as well as direct exposure, a statistical method is described here that evaluates risk with respect to individual location at the time of atomic bomb exposure instead of radiation dose. In addition, it is also considered to split the risks into separate risks due to direct exposure and other causes using radiation dose. The proposed method is applied to a cohort study of Hiroshima atomic bomb survivors. The resultant contour map suggests that the region west to the hypocenter has a higher risk compared to other areas. This in turn suggests that there exists an impact on risk that cannot be explained by direct exposure. PMID:22302183

  13. A search for mutations affecting protein structure in children of proximally and distally exposed atomic bomb survivors

    International Nuclear Information System (INIS)

    A total of 289,868 locus tests based on 28 different protein phenotypes, employing one-dimensional electrophoresis to detect variant proteins, has yielded one probable mutation in the offspring of 'proximally exposed' parents, who received an estimated average gonadal exposure dose of between 31 and 39 rem from the atomic bombs in Hiroshima and Nagasaki. There were no mutations in 208,196 locus tests involving children of 'distally exposed' parents, who had essentially no radiation exposure. (author)

  14. JNIH-ABCC life span study of children born to atomic bomb survivors. Report 1. Influence of concomitant variables upon mortality rate comparison

    Energy Technology Data Exchange (ETDEWEB)

    Kato, Hiroo; Ueda, Shoichi

    1963-04-18

    The study of mortality rates among children born to atomic bomb survivors is being conducted according to the protocol, and at present, data for those whose parents are included in the Life Span Study sample are ready for analysis. Using this portion, the influence of various concomitant factors on the infant mortality rate was investigated. The distribution of year of birth, maternal age, and birth order differs between comparison groups. The differences introduce fairly large biases into mortality rate comparisons. For example, the infant mortality rate in children, both of whose parents were atomic bomb survivors would be overestimated by 10% or more. As far as such concomitant factors are observable, the bias can be reduced to negligible magnitude. Other factors are equally important but difficult to observe. For example, environmental factors influence mortality a great deal but adequate methods for treating such factors have not yet been found. If such bias is not eliminated, conclusions to be derived from this study suffer serious limitation, namely, unless drastic radiation effects exist, neither existence nor absence of radiation effects will be demonstrable. Investigation is continuing, especially concerning: how to measure environmental factors; regression analysis on radiation dose or distance from the hypocenter; and examination of specific causes of death. 7 references, 4 figures, 9 tables.

  15. A study on social life and mental health of middle-aged and elderly atomic bomb survivors. Analysis of general health questionnaire (GHQ-30)

    International Nuclear Information System (INIS)

    The psychological state of middle aged and elderly atomic bomb survivors was analyzed by GHQ, which had been done from September to November, 1992. Subjects were 1,399 Nagasaki survivors of the average age of 61.3 y and 1,054 non-irradiated people of 62.2 y living in the countryside of Nagasaki prefecture as the control. Analyses were performed with χ square method and t-test. When the subordinate measure derived from factor analysis of GHQ was compared with that of the control group, the score possibly attributable to anxiety reaction to the stress was significantly higher in the survivors. However, the two scores attributable to obstacle in personal relations and to avoidance of social activities were significantly lower, which suggested that the survivors are able to have rich personal and social interactions. Besides, it was suggested that the GHQ score was increased possibly by anxiety for the future in the essential part of life such as loss of feeling of healthiness and dissatisfaction for the present life conditions. It was confirmed that systematic and continuous examinations are necessary from the bio-psycho-social viewpoint. (H.O.)

  16. Atomic bomb irradiation-induced leukemias revisited. Summary data of 50 years-long term follow up study on survivors

    Energy Technology Data Exchange (ETDEWEB)

    Tomonaga, Masao [Nagasaki Univ. (Japan). Atomic Disease Inst.; Matsuo, Tatsuki; Preston, D.L.; Bennett, J.M.

    1997-12-01

    The Life Span Study (LSS) on 93,741 survivors (fixed cohort) and the Open City Study (OCS) on all survivors (unfixed) irrespective of whether they belonged to LSS or not, have been conducted in parallel over 45 years to ensure reliable case detection. We adopted the FAB classification for acute leukemias and for exposure dose of individual survivors, the new dosimetry system 1986 (DS86). In LSS, 221 leukemia cases were analysed. There was strong evidence of radiation-induced risks for acute myeloid leukemia (AML), acute lymphoid leukemia (ALL) and chronic myeloid leukemia (CML), but not for adult T-cell leukemia and chronic lymphocytic leukemia. There was also significant difference between three major types with respect to the effects of age at bombing and sex, and in the temporal pattern of the elevated risks. For AML the dose response function was non-linear, whereas there was no evidence against linearity for ALL and CML. The hypothesis of a 0.5 Gy threshold could be rejected for three major types of leukemia. Excess Absolute Risk (EAR) estimates in cases per 10,000 Person Year Sievert (PYSv) were 0.6, 1.1, 0.9 for ALL, AML and CML, respectively. The corresponding relative risk at 1.0 Sv were 9.1, 3.3, 6.2, respectively. Although childhood exposure <15 age at bombing apparently induced three major types, the age-related highest risk was observed for ALL. In OCS, 413 cases with DS86 estimates were used for analysis. Type specific incidence rates were calculated indirectly by using the over all incidence of leukemia from LSS data and multiplying these values by the corresponding proportions of cases in OCS. In conjunction with LSS data, the effects of radiation were significantly greater on the incidences of ALL and CML than on that of AML. In the high dose group there was a strong evidence for shorter incubation time and faster decline of elevated risk for ALL and CML than for AML. AML risk was apparently persistent through 1980. (K.H.)

  17. Search for mutations altering protein charge and/or function in children of atomic bomb survivors: final report.

    OpenAIRE

    Neel, J V; Satoh, C; Goriki, K; Asakawa, J; M Fujita; Takahashi, N.; Kageoka, T; Hazama, R.(Research Center for Nuclear Physics and Department of Physics, Osaka University, Ibaraki, Osaka 567-0047, Japan)

    1988-01-01

    A sample of (1) children whose parents had been proximally exposed (i.e., less than 2,000 m from the hypocenter) at the time of the atomic bombings of Hiroshima and Nagasaki and (2) a suitable comparison group have been examined for the occurrence of mutations altering the electrophoretic mobility or activity of a series of 30 proteins. The examination of the equivalent of 667,404 locus products in the children of proximally exposed persons yielded three mutations altering electrophoretic mob...

  18. Association between mortality and residual radiation in Nagasaki atomic bomb survivors exposed at long-distance from the hypocenter

    International Nuclear Information System (INIS)

    Mortality of Nagasaki A-bomb survivors exposed at 3 km or longer distance from the hypocenter was compared with that of those who were additionally exposed to residual radiation because of their entrance in the area at 1 km or closer to the center within 24 hr post explosion. The latter survivors (group I), 2,357 men with average age of 28.4 y and 2,618 women of 26.5 y at the exposure, were alive at 1970, and the former (group II, without exposure to residual radiation) was selected to match their numbers in sex, exposed distance, ages at exposure and at start of the follow-up study to those of group I. Follow-up was conducted from 1970 to 2007, and their total, malignant, cerebrovascular, cardiac and pneumonic deaths were observed. Cox proportional hazard model was used for estimation of mortality risk with covariates of sex and age at start of the study. The risk in group II was defined to be standard. Ages at start of the study were 53.3 and 51.4 y in men and women, respectively. Crude mortality tended to be higher in men of group I at ages of 40-49 and 50-59 y at start of the study. Hazard ratios of total and malignant tumor deaths in group I were 0.965 and 1.092, respectively, without statistic significance from group II and of other deaths, 0.982-0.999, also of statistic insignificance. Thus increased mortality due to residual radiation was not observed. (T.T.)

  19. Gamma-ray and neutron dosimetry by EPR and AMS, using tooth enamel from atomic-bomb survivors: a mini review.

    Science.gov (United States)

    Nakamura, Nori; Hirai, Yuko; Kodama, Yoshiaki

    2012-03-01

    The electron paramagnetic resonance (EPR, or electron spin resonance) method was used to measure CO₂⁻· radicals recorded in tooth enamel by exposure to atomic-bomb gamma rays. The EPR-estimated doses (i.e. ⁶⁰Co gamma-ray equivalent dose) were generally in good correlation with cytogenetic data of the same survivors, whereas plots of EPR-estimated dose or cytogenetically estimated dose against DS02 doses turned out to scatter more widely. Because those survivors whose EPR doses were higher (or lower) than DS02 doses tended to show also higher (or lower) responses for cytogenetic responses, the apparent variation appears primarily due to problems in individual DS02 doses rather than the measurement errors associated with the EPR or cytogenetic technique. A part of the enamel samples were also used for evaluation of neutron doses by measuring ⁴¹Ca/⁴⁰Ca ratios using the accelerator mass spectrometry technique. The results for the measured ratios were on average ~85 % of the calculated ratios by DS02 (but within the 95 % confidence bounds of the simulated results), which lends support to DS02-derived neutron doses to the survivors. PMID:22267275

  20. Simulation-extrapolation method to address errors in atomic bomb survivor dosimetry on solid cancer and leukaemia mortality risk estimates, 1950-2003.

    Science.gov (United States)

    Allodji, Rodrigue S; Schwartz, Boris; Diallo, Ibrahima; Agbovon, Césaire; Laurier, Dominique; de Vathaire, Florent

    2015-08-01

    Analyses of the Life Span Study (LSS) of Japanese atomic bombing survivors have routinely incorporated corrections for additive classical measurement errors using regression calibration. Recently, several studies reported that the efficiency of the simulation-extrapolation method (SIMEX) is slightly more accurate than the simple regression calibration method (RCAL). In the present paper, the SIMEX and RCAL methods have been used to address errors in atomic bomb survivor dosimetry on solid cancer and leukaemia mortality risk estimates. For instance, it is shown that using the SIMEX method, the ERR/Gy is increased by an amount of about 29 % for all solid cancer deaths using a linear model compared to the RCAL method, and the corrected EAR 10(-4) person-years at 1 Gy (the linear terms) is decreased by about 8 %, while the corrected quadratic term (EAR 10(-4) person-years/Gy(2)) is increased by about 65 % for leukaemia deaths based on a linear-quadratic model. The results with SIMEX method are slightly higher than published values. The observed differences were probably due to the fact that with the RCAL method the dosimetric data were partially corrected, while all doses were considered with the SIMEX method. Therefore, one should be careful when comparing the estimated risks and it may be useful to use several correction techniques in order to obtain a range of corrected estimates, rather than to rely on a single technique. This work will enable to improve the risk estimates derived from LSS data, and help to make more reliable the development of radiation protection standards. PMID:25894839

  1. Monitoring exposure to atomic bomb radiation by somatic mutation.

    OpenAIRE

    Akiyama, M.; Kyoizumi, S; Kusunoki, Y; Hirai, Y; Tanabe, K; Cologne, J B

    1996-01-01

    Atomic bomb survivors are a population suitable for studying the relationship between somatic mutation and cancer risk because their exposure doses are relatively well known and their dose responses in terms of cancer risk have also been thoroughly studied. An analysis has been made of erythrocyte glycophorin A (GPA) gene mutations in 1,226 atomic bomb survivors in Hiroshima and Nagasaki. The GPA mutation frequency (Mf) increased slightly but significantly with age at the time of measurement ...

  2. Radiation-related posterior lenticular opacities in Hiroshima and Nagasaki atomic bomb survivors based on T65DR and DS86 dosimetry systems

    International Nuclear Information System (INIS)

    This paper investigates the quantitative relationship of ionizing radiation to the occurrence of posterior lenticular opacities among the survivors of the atomic bombings of Hiroshima and Nagasaki, as suggested by the DS86 dosimetry system. DS86 doses are available for 1,983 (93.4%) of the 2,124 A-bomb survivors analyzed in 1982. In the DS86 system, both gamma-ray and neutron regression coefficients for the best-fitting model are positive and highly significant for the estimated energy deposited in the eye, here termed the eye organ dose. The DS86 gamma regression coefficient is almost the same as that associated with the T65DR gamma kerma, the ratio of the two coefficients being 1.1 (95% confidence limits: 0.5 - 2.3) for D86 kerma in the individual data. The relative biological effectiveness (RBE) values based on the individual gamma and neutron components of the DS86 eye organ dose are estimated to be 32.4 + 0.73/(Dν - 0.06)>0 with the 95% confidence limits ranging from 11.8 to 88.8 + 1.39/(Dν - 0.06)>0, where Dν is the neutron dose in gray. It is suggested that the neutron component could be more important for the eyes than for other sites of the body. Finally, it is interesting to observe that a linear-quadratic gamma and linear neutron model with two thresholds, which fits the data less well, produces very similar estimates of the two thresholds as the linear gamma-linear neutron-response model. In this model, however, the regression coefficient is not significantly associated with the quadratic gamma response. (J.P.N.)

  3. Pathological study on breast lesions examined at Hiroshima Red Cross Hospital and Atomic Bomb Survivors Hospital, April 1985-March 1990

    International Nuclear Information System (INIS)

    An analysis of 312 breast biopsies of 303 patients, performed during a 5-year period from April 1985 through March 1990 in a survey of the effects of exposure to A-bomb radiation, yielded the following findings. Sixty four (20.5%) of the 312 biopsies were in patients who had been exposed to A-bomb radiation or who had entered the city after the A-bombing, 10 of which were in patients exposed at up to 2,000 m from the hypocenter. Of the 64 biopsies performed for breast lesions in the exposed group, 42 (65.6%) yielded breast cancer. This figure was higher when compared with 47.0% (64 biopsies) of 136 patients who had been born before the A-bombing in the non-exposed group. In the exposed group, age distribution at the time of A-bombing was 11.9% in the first decade, 35.7% in the second decade, 31.0% in the third decade, 16.7% in the fourth decade, and 4.8% in the fifth decade. There was no correlation between histology type and exposure history in breast cancer. Nor did correlation exist between the age at the time of A-bombing and histology type in the exposed group. (N.K.)

  4. Search for mutations altering protein charge and/or function in children of atomic bomb survivors: final report

    International Nuclear Information System (INIS)

    A sample of children whose parents were proximally exposed at the time of the atomic bombings of Hiroshima and Nagasaki (i.e., within 2,000 m of the hypocenter) and a suitable comparison group have been examined for the occurrence of mutations altering the electrophoretic mobility or activity of a series of 30 proteins. The examination of the equivalent of 667,404 locus products in the children of proximally exposed persons yielded three mutations altering electrophoretic mobility; the corresponding figure for the comparison group was three mutations in 466,881 tests. The examination of a subset of 60,529 locus products for loss of enzyme activity in the children of proximally exposed persons yielded one mutation; no mutations were encountered in 61,741 determinations on the children of the comparison group. Combining these two series, the mutation rate observed in the children of proximally exposed is thus 0.60 x 10-5/locus/generation, with 95 % confidence intervals between 0.2 and 1.5 x 10-5, and in the comparison children, 0.64 x 10-5/locus/generation, with 95 % intervals between 0.1 and 1.9 x 10-5. The average conjoint gonad doses of the proximally exposed parents are estimated to be 0.437 Gy of gamma radiation and 0.002 Gy of neutron radiation. Assigning a relative biological effectiveness of 20 to the neutron radiation, the combined total gonad dose of the parents becomes 0.477 Sv. (author)

  5. Serum TSH, thyroglobulin, and thyroid disorders in atomic bomb survivors exposed in youth: a study 30 years after exposure

    International Nuclear Information System (INIS)

    A study of individuals in Hiroshima and Nagasaki who were under 20 years of age at the time of atomic bomb exposure and who had been exposed to 100+ rad was conducted to determine the frequency of thyroid disorders as well as the levels of serum thyroid stimulating hormone (TSH), antithyroglobulin antibody, and thyroglobulin (TG), 30 years after exposure. Thyroid disorders were detected in 56 of the 477 subjects of the 100+ rad exposed group and in 39 of the 501 subjects of the 0 rad exposed group, the prevalence being significantly higher in the former group (X2 = 3.872, P = 0.049). This increased prevalence of thyroid disorders in the 100+ rad exposed group was due to the increased occurrence of thyroid cancer and nontoxic uninodular goiter. Thyroid cancer was found in eight exposed individuals, all of whom belonged to the 100+ rad group; statistically, the prevalence was significantly higher (X2 = 7.919, P = 0.005). Nontoxic uninodular goiter was observed in 13 cases of the 100+ rad exposed group and 3 cases of the 0 rad exposed group, the prevalence in the 100+ rad exposed group being significantly higher (X2 = 6.584, P = 0.010). In these cases no increase of serum TSH or TG levels was observed. Mean serum TSH levels in individuals without thyroid disorders were 1.64 ± 1.89 μU/ml (n = 421) in the 100+ rad exposed group and 1.54 ± 1.86 μU/ml (n = 462) in the 0 rad exposed group. Mean serum TG levels were 13.49 ± 13.88 ng/ml (n = 421) in the 100+ rad exposed group and 14.76 ± 15.69 ng/ml (n = 462) in the 0 rad exposed group. Thus, these differences between the two groups were not significant. Also, no significant differences were observed between the 100+ rad and 0 rad exposed groups in the mean serum TSH and TG levels of the subjects who had thyroid diseases but had not been treated for the diseases, and the subjects who had no thyroid diseases. (J.P.N.)

  6. Biomarkers of Radiosensitivity in A-Bomb Survivors Pregnant at the Time of Bombings in Hiroshima and Nagasaki

    OpenAIRE

    Masazumi Akahoshi; Saeko Fujiwara; Kei Nakachi; Yoichiro Kusonoki; Thomas Seed; Yoshiaki Kodama; Eiji Nakashima; Naoko Kamada; Sachiyo Funamoto; Yoshimi Tatsukawa; Miles, Edward F.; Kazuo Neriishi

    2011-01-01

    Purpose. There is evidence in the literature of increased maternal radiosensitivity during pregnancy. Materials and Methods. We tested this hypothesis using information from the atomic-bomb survivor cohort, that is, the Adult Health Study database at the Radiation Effects Research Foundation, which contains data from a cohort of women who were pregnant at the time of the bombings of Hiroshima and Nagasaki. Previous evaluation has demonstrated long-term radiation dose-response effects. Results...

  7. Incidence of leukemia in a fixed cohort of atomic bomb survivors and controls, Hiroshima and Nagasaki October 1950 - December 1978

    International Nuclear Information System (INIS)

    The present analysis of leukemia incidence is confined to 189 cases in Hiroshima and Nagasaki. The analysis again demonstrates that the risk of all types of leukemia has increased with dose in both cities except among individuals who received less than 100 rad in kerma total dose in Nagasaki. The shape of the dose-response curve is different in the two cities and between the two major types of leukemia (acute leukemia and chronic granulocytic leukemia), though the average marrow total dose is quite similar in each total kerma dose class in the two cities. The present findings are quite consistent with those described in the previous report. The excess risk among survivors who received 100 rad or more kerma total dose has gradually declined with years after exposure in both cities. It had disappeared among Nagasaki survivors by 1970 (25 years after exposure) but the risk was still high even after 1970 among exposed survivors in Hiroshima who were 30 years of age or older ATB. The leukemogenic effect of radiation differs in relation to dose, age ATB, and duration after exposure between Hiroshima and Nagasaki survivors. The analysis has again supported previous observations that the leukemogenic effect of radiation in those individuals exposed at younger ages ATB was greater in the early postbomb period and declined more rapidly in subsequent years, while the effect in older individuals ATB appeared later and persisted longer. (author)

  8. Combining diagnostic categories to improve agreement between death certificate and autopsy classifications of cause of death for atomic bomb survivors, 1950-87

    International Nuclear Information System (INIS)

    Several investigators have observed less-than-desirable agreement between death certificate diagnoses and autopsy diagnoses for most specific causes of death, and even for some causes grouped by major disease category. Our results from data on 5130 autopsies of members of the Life Span Study cohort of atomic bomb survivors in Hiroshima and Nagasaki conducted prior to September 1987 were equally discouraging. Among diseases with more than 10 cases observed, confirmation rates ranged from 13 % to 97 % and detection rates from 6 % to 90 %. Both rates were greater than 70 % for only 6 of 60 disease categories studied and for only 1 of 16 categories defined by major International Classification of Disease categories (neoplasms). This deficiency suggests cautious interpretation of results from studies based on death certificate diagnoses. To determine whether any groupings of diagnoses might meet acceptable accuracy requirements, we applied a hierarchical clustering method to data from these 5130 cohort members. The resulting classification system had 10 categories: breast cancer; other female cancers; cancers of the digestive organs; cancer of the larynx; leukemia; nasal, ear, or sinus cancer; tongue cancer; external causes; vascular disease; and all other causes. Confirmation and detection rates for each of these categories were at least 66 %. Although the categories are broad, particularly for nonneoplastic diseases, further divisions led to unacceptable accuracy rates for some of the resulting diagnostic groups. Using the derived classification system, there was 72 % agreement overall between death certificate and autopsy diagnoses compared to 53 % agreement for a second system obtained by grouping strictly by major disease category. Eighty-seven percent agreement was observed for a similar classification system with vascular disease grouped with all other nonneoplastic diseases. Further agglomeration achieved very little additional improvement. (J.P.N.)

  9. Malignant tumors and multiple primary malignant tumors of the atomic-bombed survivors in Nagasaki by autopsy cases

    International Nuclear Information System (INIS)

    Out of 10,674 bodies necropsied in Nagasaki district during 32 years period after World War II, 9,302 were selected, and their malignant tumors and multiple primary malignant tumors were discussed. They were divided into 4 groups, the group exposed within 1,000 m from the hypocenter, the group exposed within 2,000 m, the group exposed over 2,000 m + the group who entered the city after the explosion, and the non-exposed group who were born before the explosion. The percentage of cases of malignant tumors (4,784) was 51.4%, which was almost the same as the average in Japan. The incidence of multiple malignant tumors (112 cases of double cancer and 7 cases of triple cancer) was 2.48% of all malignant tumors, and it did not increase particularly. The incidence of malignant tumors and multiple malignant tumors tended to increase with the age. The incidence of malignant tumors was a little high in the group exposed within 1,000 m, and the incidence of leukemia and thyroid cancer was high in the group exposed near the hypocenter in Nagasaki as same as in Hiroshima. The incidence of multiple malignant tumors was markedly high in the group exposed near the hypocenter. This tendency was also shown in Hiroshima. The incidence of multiple malignant tumors was also high in women. In the group exposed near the hypocenter, there were many cases of digestive cancer or thyroid cancer combined with cancers of other organs. Multiple malignant cancer combined with leukemia was found only in one case. There were many combinations of cancer with cancer, but there was not a relation between a-bomb exposure and cancer or sarcoma. The time of onset of multiple malignant tumors was different in many cases of the exposed. (Tsunoda, M.)

  10. Report on the results of the seventh medical examination of atomic bomb survivors in the South America

    Energy Technology Data Exchange (ETDEWEB)

    Ishioka, Shinichi [Hiroshima Univ. (Japan). School of Medicine; Ohta, Nobuhiro; Taguchi, Atsushi; Okada, Fumio; Hara, Tokihiro; Ueno, Kouki

    1997-06-01

    The medical examination was carried out in Brazil, Paraguay, Bolivia, Argentina and Peru on 80, 4, 7, 11 and 3 survivors, respectively, from Oct. 30 to Nov. 15, 1996. They (43 males and 62 females) were 66.5 years old in average. The examination involved physical measurements, blood and urine analyses, electrocardiography, health questionnaire and consultation with blood pressure measurement. Results were as follows: Anamnesis; hypertension (51.4%), heart diseases (23.8%), cancer (21.0%), diabetes (19.0%), hemorrhoids (19.0%), stroke (18.1%), stomach ulcer (12.4%) and others: Present major disease; hypertension (23.8%), diabetes (6.7%), heart diseases (6.7%), cancer (6.7%) and others. Loss of vigor (63.8%), complete exhaustion or fatigue (63.8%), heat intolerance (60.0%), numbness or tingling (43.8%), failure of memory (42.9%) and many others were recognized as subjective symptoms. Blood pressure measurement gave hypertensive findings in 31.4%. Normal ECG was found in 67.7%. Cases judged to be necessary for further examinations or for treatment were in 46.7%. This examination was concluded to be continued. (K.H.)

  11. A comparison of the risk of stillbirth associated with paternal pre-conception irradiation in the Sellafield workforce with that of stillbirth and untoward pregnancy outcome among Japanese atomic bomb survivors

    Energy Technology Data Exchange (ETDEWEB)

    Little, M.P. [National Radiological Protection Board, Chilton, Didcot, Oxon OX11 0RQ (United Kingdom)

    1999-12-01

    A comparison is made of the relative risks associated with paternal pre-conception irradiation of stillbirth and untoward pregnancy outcome (stillbirths, congenital malformations, neonatal deaths) in the offspring of the Japanese atomic bomb survivors and of stillbirth in the offspring of Sellafield workers. It is concluded that the pre-conception exposure risks of stillbirth in the offspring of Sellafield workers are statistically incompatible with the Japanese data at the 5% level. Other human and experimental data relating to the induction of congenital abnormalities are briefly reviewed. (author)

  12. New dosimetry of atomic bomb radiations.

    Science.gov (United States)

    Fry, R J; Sinclair, W K

    1987-10-10

    The reassessment of the radiation dosimetry from the Hiroshima and Nagasaki atomic bombs is almost complete. Since atomic bomb survivors provide a major source of data for estimates of risk of cancer induction by radiation the impact of the new dosimetry on risk estimates and radiation protection standards is important. The changes include an increase of about 20% in the estimated yield of the Hiroshima bomb and a reduction in the estimated doses from neutrons in both cities. The estimated neutron dose for Hiroshima is about 10% of the previous estimate. The neutron doses are now so small that direct estimates of neutron relative biological effectiveness may be precluded or be much more difficult. There is little change in most of the gamma ray organ doses because various changes in the new estimates tend to cancel each other out. The new estimate of the attenuation of the free-in-air kerma by the walls of the homes is about twice that used in the previous dosimetry. But the transmission of gamma radiation to the deep organs such as bone marrow is significantly greater than earlier estimates. Probably future risk estimates for radiogenic cancer will be somewhat higher because of both the new dosimetry and the new cancer mortality data. New risk estimates should be available in 1988. PMID:2889042

  13. Radioepidemiology of the A-bomb survivors.

    Science.gov (United States)

    Schull, W J

    1996-06-01

    Estimation of the risk of cancer and other health effects following exposure to the atomic bombing of Hiroshima and Nagasaki remains largely empirical, and the models used to adduce risk incorporate few, if any, of the advances in molecular biology of the past decade or so. These facts compromise the estimation of risk where the epidemiologic data are weakest, namely, at low doses and dose rates. Although the risk estimates may be sufficient for regulatory purposes, without a better understanding of the molecular and cellular events ionizing radiation initiates or promotes, it seems unlikely that the estimates will be as intellectually satisfying as they might be. Nor will the situation improve further without attention to the identification and estimation of the effects of those host and environmental factors that enhance or diminish risk of cancer or the effects on the developing brain. PMID:8635903

  14. Long-Term Health Effects of Atom Bomb on Japan Not as Bad as Feared: Study

    Science.gov (United States)

    ... Long-Term Health Effects of Atom Bomb on Japan Not as Bad as Feared: Study Survivors of ... 2011 at a nuclear power plant in Fukushima, Japan, after an earthquake triggered a massive tsunami shows ...

  15. Hiroshima: Perspectives on the Atomic Bombing.

    Science.gov (United States)

    Cheng, Amy

    In this curriculum module students analyze both U.S. and Japanese perspectives of the atomic bombing of Hiroshima. The activities integrate Howard Gardner's work on multiple intelligences. The module is recommended as a supplement to textbook coverage of the war in the Pacific and of the atomic bombing of Hiroshima. It can be used to support both…

  16. A prospective follow-up study of the association of radiation exposure with fatal and non-fatal stroke among atomic bomb survivors in Hiroshima and Nagasaki (1980–2003)

    Science.gov (United States)

    Abbott, Robert D; Ohshita, Tomohiko; Takahashi, Tetsuya; Ozasa, Kotaro; Akahoshi, Masazumi; Fujiwara, Saeko; Kodama, Kazunori; Matsumoto, Masayasu

    2012-01-01

    Objective Use of medical radiotherapy has increased markedly in recent decades. Whether the consequence includes an increased risk of cardiovascular disease remains to be determined. The purpose of this study was to examine the association between radiation exposure and the incidence of stroke among Japanese atomic bomb survivors. Design A prospective follow-up study. Setting and participants Radiation exposure from the atomic bombing was assessed in 9515 subjects (34.8% men) with 24-year follow-up from 1980. Subjects were free of prevalent stroke when follow-up began. Outcome measures Stroke events and the underlying cause of death were reviewed to confirm the first-ever stroke. Subtypes (ischaemic and haemorrhagic events) were categorised based on established criteria according to the definitions of typical/atypical stroke symptoms. Results Overall mean radiation dose (±SD) in units of gray (Gy) was 0.38±0.58 (range: 0–3.5). During the study period, 235 haemorrhagic and 607 ischaemic events were identified. For men, after adjusting for age and concomitant risk factors, the risk of haemorrhagic stroke rose consistently from 11.6 to 29.1 per 10 000 person-years as doses increased from effects in women are less apparent until doses exceed a threshold at 1.3 Gy. PMID:22307102

  17. Cardiovascular disease mortality of A-bomb survivors and the healthy survivor selection effect.

    Science.gov (United States)

    Schöllnberger, H; Ozasa, K; Neff, F; Kaiser, J C

    2015-09-01

    The latest A-bomb survivor data for cardiovascular diseases are analysed to investigate whether in the first years after the bombings the baseline rates of proximal survivors were markedly different compared with those of the distal survivors. This phenomenon relates to a healthy survivor selection effect. This question is important for the decision whether to include or exclude the early years of follow-up when analysing the biological effects from acute low and high dose exposures following the nuclear weapons explosions in Hiroshima and Nagasaki. The present study shows that for cerebrovascular diseases and heart diseases the baseline rates are not significantly different in the first two decades of follow-up. Thus, for these two detrimental health outcomes, there is no need to exclude distal survivors and the first decades of follow-up time when investigating the shapes of the related dose-responses. PMID:25948837

  18. The quality of DNA recovered from the archival tissues of atomic bomb survivors is good enough for the single nucleotide polymorphism analysis in spite of the decade-long preservation in formalin

    International Nuclear Information System (INIS)

    It is well known that the yield of DNA recovered form tissues preserved in formalin is inversely proportional to the stored duration. How is the quality? We tested the quality of DNA from archival tissues of atomic-bomb survivors stored in formalin for decades with the parameters of gene amplification efficiency by a polymerase chain reaction. All of the DNA extracted from the tissues preserved in formalin for 30 years amplified the 54- and 61-base pairs of the DNA fragments successfully. The direct sequencing of the PCR products confirmed the accurate amplification of the target sequence. A further trial to amplify the longer sequence of 111 base pairs succeeded in 20% of the samples tested. From these results, we propose a new utility of archival samples for the analysis of single nucleotide sequence polymorphism of genes, no matter how long the samples have been preserved in formalin. (author)

  19. Contributing factors to long-term psychological consequences in Hiroshima A-bomb survivors

    International Nuclear Information System (INIS)

    The atomic bombing in Hiroshima on August 6, 1945, caused an estimated casualty of 140,000 by the end of that year. Survivors faced hideous scenes and many lost family members. Later, in the early 1960s, increased rates of leukemia and other types of cancer were observed among the survivors. These long-term health effects caused serious apprehension to linger. However, only a few studies on psychological consequences among the survivors have been conducted. In 2008, Hiroshima City commissioned our study team to perform a large-scale survey on long-term health effects among the survivors. We delivered a questionnaire by mail to all subjects who were living in Hiroshima City and adjacent towns prior to the release of the A-bomb until the study was implemented. The number of potential subjects was 31,598 and the response rate was 75%. We analyzed a subsample of subjects (n=14,373) whose age at the event was 8 or above. In the multiple regression analysis, hibakusha (A-bomb victims) and those who were exposed to the Black Rain (fall-out) showed poor mental health compared to the comparison group on SF-8, K6 and IES-R scores even after adjusting socio-demographic variables. Although traumatic experiences at the event still affected mental health, anxiety for health effects and social stigma showed greater impact. Our findings suggest that even 63 years after the event, apprehension of health effects and social stigma harm mental health in A-bomb survivors. Our findings may also suggest that long-term risk communication will be vital to mitigate mental health effects among survivors of the Fukushima nuclear disaster. (author)

  20. Study of biochemical examination among A-bomb survivors

    International Nuclear Information System (INIS)

    Biochemical findings were compared in 1003 A-bomb survivors exposed at ≤1900 m from the hypocenter and 1003 age- and sex-matched A-bomb survivors exposed at ≥3,000 m. Mean and abnormal values for lung function, such as total protein, GOT and GPT, did not differ in two groups of both men and women. However, mean values of both total cholesterol and neutral fat were significantly higher in the ≤1900m group than in the ≥3000 m group, irrespective of sex. Similarly, the ≤1900 m group had a significantly higher incidence of abnormal values for these items than the ≥3000 m group. (N.K.)

  1. Leukemia among a-bomb survivors living in Hiroshima city, 1971-1978

    International Nuclear Information System (INIS)

    The death from leukemia among Hiroshima citizens from 1971 to 1978 was investigated. The total number of dead citizens was 241, and 64 of them were a-bomb survivors. Thirty-seven of a-bomb survivors were exposed to a-bomb within 2 km from hypocenter. Seventy-seven of remaining 177 citizens were born after the explosion of a-bomb, but they were not children of a-bomb survivors exposed directly to a-bomb. The mortality of a-bomb survivors exposed near the hypocenter was 1.67 (within 2 km) - 2.51 (within 1.5 km) times that of those exposed far from the hypocenter. The mortality of a-bomb survivors exposed within 1.5 km was significantly high. The death risk from leukemia was significantly high in women. The estimated exposure dose was over 1 rad in 25 of abovementioned 37 a-bomb survivors, and it was over 10 rad in 21 and over 100 rad in 10 of 25. Seven of 10 a-bomb survivors exposed over 100 rad were women. The age at the exposure was under 10 years in 1, teens in 1, twenties in 2, and over thirty in 6. The type of leukemia was acute in 8 and chronic in 2. Both types were myelogenous leukemia. Five of these 10 a-bomb survivors died after 1976. (Tsunoda, M.)

  2. Yale and the Atomic Bomb Casualty Commission.

    OpenAIRE

    Bowers, J. Z.

    1983-01-01

    This is a description, based largely on personal discussions, of the contributions of men from the Yale University School of Medicine to the saga of the immediate and long-term studies on the medical effects of the atomic bombs at Hiroshima and Nagasaki. They played key roles in the immediate studies of bomb effects, in the creation of long-term studies of delayed effects, and in elevating the Atomic Bomb Casualty Commission after 1955 to a position of excellence in its studies and relations ...

  3. A Clinical and Chromosomal Study on Those Exposed to the Atomic Bomb and their Offspring

    OpenAIRE

    Chung, Jung Myung; Choe, Ha Jin

    1987-01-01

    Presented in this paper is the data from clinical laboratory examination of 50 Korean atomic-bomb survivors (Hiroshima and Nagasaki, Japan, 1945). Of them, 15 survivors were karyotyped from their lymphocyte culture for both “stable” and “unstable” types of chromosomal aberrations. Eight of their offspring were also tested for the chromosomal changes and SCE as well. The results are as follows: All survivors were found to have suffered from various diseases, particularly from respiratory disea...

  4. Yale and the Atomic Bomb Casualty Commission

    International Nuclear Information System (INIS)

    This is a description, based largely on personal discussions, of the contributions of men from the Yale University School of Medicine to the saga of the immediate and long-term studies on the medical effects of the atomic bombs at Hiroshima and Nagasaki. They played key roles in the immediate studies of bomb effects, in the creation of long-term studies of delayed effects, and in elevating the Atomic Bomb Casualty Commission after 1955 to a position of excellence in its studies and relations with the Japanese. The accumulation of the information presented in this paper derives from research for the preparation of the history of the Atomic Bomb Casualty Commission. In 1975, the commission was passed to Japanese leadership as the Radiation Effects Research Foundation

  5. Greetings: 50 years of Atomic Bomb Casualty Commission–Radiation Effects Research Foundation studies

    OpenAIRE

    Shigematsu, Itsuzo

    1998-01-01

    The Atomic Bomb Casualty Commission was established in Hiroshima in 1947 and in Nagasaki in 1948 under the auspices of the U.S. National Academy of Sciences to initiate a long-term and comprehensive epidemiological and genetic study of the atomic bomb survivors. It was replaced in 1975 by the Radiation Effects Research Foundation which is a nonprofit Japanese foundation binationally managed and supported with equal funding by the governments of Japan and the United Sta...

  6. Monitoring exposure to atomic bomb radiation by somatic mutation.

    Science.gov (United States)

    Akiyama, M; Kyoizumi, S; Kusunoki, Y; Hirai, Y; Tanabe, K; Cologne, J B

    1996-05-01

    Atomic bomb survivors are a population suitable for studying the relationship between somatic mutation and cancer risk because their exposure doses are relatively well known and their dose responses in terms of cancer risk have also been thoroughly studied. An analysis has been made of erythrocyte glycophorin A (GPA) gene mutations in 1,226 atomic bomb survivors in Hiroshima and Nagasaki. The GPA mutation frequency (Mf) increased slightly but significantly with age at the time of measurement and with the number of cigarettes smoked. After adjustment for the effect of smoking, the Mf was significantly higher in males than in females and higher in Hiroshima than in Nagasaki. All of these characteristics of the background GPA Mf were in accord with those of solid tumor incidence obtained from an earlier epidemiological study of A-bomb survivors. Analysis of the dose effect on Mf revealed the doubling dose to be about 1.20 Sv and the minimum dose for detection of a significant increase to be about 0.24 Sv. No significant dose effect for difference in sex, city, or age at the time of bombing was observed. Interestingly, the doubling dose for the GPA Mf approximated that for solid cancer incidence (1.59 Sv). And the minimum dose for detection was not inconsistent with the data for solid cancer incidence. The dose effect was significantly higher in those diagnosed with cancer before or after measurement than in those without a history of cancer. These findings are consistent with the hypothesis that somatic mutations are the main cause of excess cancer risk from radiation exposure. PMID:8781371

  7. Chromosome survey for children of A-bomb survivors

    International Nuclear Information System (INIS)

    To investigate chromosomes from children of A-bomb survivors, cytogenetic survey has been started in 1967 by the ABCC and completed in 1985 by the succeeding RERF. This paper is designed to overview the cytogenetic survey and to discuss the cytogenetic effects of A-bomb radiation. A cohort of 16,298 children of A-bomb survivors, which were collected from mortality survey population in 1974, was enrolled in this survey and was divided into two groups: the proximally exposed group (n=8,322, whose parents exposed to estimated doses of 0.01 Gy or more within 2,000 m from the hypocenter) and the distally exposed group (n=7,976, those exposed to 0.005 Gy or less far from 2,500 m or not in the city). Three chromosomal aberrations were identified: sex chromosome aberrations consisting mainly of XYY, XXY, and mosaic; structural abnormality of autosomes consisting mainly of translocation and inversion; and trisomy of autosomes. Overall, the incidence of chromosomal aberrations was higher in the distally exposed group (6.39%) than the proximally exposed group (5.17%). According to the type of chromosomal aberrations, the incidences of both sex chromosomes and structural abnormality of autosomes were slightly higher in the distally exposed group (0.30% and 0.34%) than the proximally exposed group (0.23% and 0.28%). Trisomy of autosomes was identified in only one child in the proximally exposed group. These findings failed to demonstrate the rationale for the cytogenetic effects of A-bomb radiation; however, cytogenetic risk of radiation has not been denied completely. (N.K.)

  8. A-bomb survivors: reassessment of the radiation hazard.

    Science.gov (United States)

    Stewart, A M; Kneale, G W

    1999-01-01

    Newly released data from the Radiation Effects Research Foundation on the survivors of the Hiroshima and Nagasaki A-bombing allow a reassessment of radiation hazards. It appears that deaths from marrow damage (such as aplastic anaemia) continued after 1950. The Life Span Study cohort appears biased in favour of persons with high immunological competence, the result of infants and the elderly being more likely to die before 1950 than young adults. A study of survivors of in utero exposures suggests that embryos are more sensitive to the lethal effects of radiation than more mature foetuses. Current estimates of cancer risks from radiation may only apply to young adults with high immunological competence; young children and the elderly may be at greater risk. PMID:10218002

  9. Cover-up of the effects of internal exposure by residual radiation from the atomic bombing of Hiroshima and Nagasaki.

    Science.gov (United States)

    Sawada, Shoji

    2007-01-01

    The criteria certifying atomic bomb disease adopted by the Japanese government are very different from the actual state of the survivors. The criteria are based on epidemiological research by the Radiation Effects Research Foundation, the successor to the Atomic Bomb Casualty Commission (ABCC). The ABCC studied only the effects of primary radiation from the atomic bombing on the survivors of Hiroshima and Nagasaki, and ignored the damage from residual radiation. Analysis of the incidence of acute radiation disease, the rate of chromosomal aberrations, and the relative risks of chronic disease among the survivors, shows that the effects of residual radiation from fallout exceeds that of primary radiation in the area more than 1.5-1.7 km distant from the hypocentre of the Hiroshima bombing. The effects of internal exposure due to intake of tiny radioactive particles are more severe than those of external exposure, explaining the difference between the official criteria and the actual state of the survivors. PMID:17370859

  10. A novel RET rearrangement (ACBD5/RET) by pericentric inversion, inv(10)(p12.1;q11.2), in papillary thyroid cancer from an atomic bomb survivor exposed to high-dose radiation.

    Science.gov (United States)

    Hamatani, Kiyohiro; Eguchi, Hidetaka; Koyama, Kazuaki; Mukai, Mayumi; Nakachi, Kei; Kusunoki, Yoichiro

    2014-11-01

    During analysis of RET/PTC rearrangements in papillary thyroid cancer (PTC) among atomic bomb survivors, a cDNA fragment of a novel type of RET rearrangement was identified in a PTC patient exposed to a high radiation dose using the improved 5' RACE method. This gene resulted from the fusion of the 3' portion of RET containing tyrosine kinase domain to the 5' portion of the acyl-coenzyme A binding domain containing 5 (ACBD5) gene, by pericentric inversion inv(10)(p12.1;q11.2); expression of the fusion gene was confirmed by RT-PCR. ACBD5 gene is ubiquitously expressed in various human normal tissues including thyroid. Full-length cDNA of the ACBD5-RET gene was constructed and then examined for tumorigenicity. Enhanced phosphorylation of ERK proteins in the MAPK pathway was observed in NIH3T3 cells transfected with expression vector encoding the full-length ACBD5/RET cDNA, while this was not observed in the cells transfected with empty expression vector. Stable NIH3T3 transfectants with ACBD5-RET cDNA induced tumor formation after their injection into nude mice. These findings suggest that the ACBD5-RET rearrangement is causatively involved in the development of PTC. PMID:25175022

  11. Effects of NKG2D haplotypes on the cell-surface expression of NKG2D protein on natural killer and CD8 T cells of peripheral blood among atomic-bomb survivors.

    Science.gov (United States)

    Imai, Kazue; Hayashi, Tomonori; Yamaoka, Mika; Kajimura, Junko; Yoshida, Kengo; Kusunoki, Yoichiro; Nakachi, Kei

    2012-06-01

    NKG2D is a primary activating receptor that triggers cell-mediated cytotoxicity in NK cells against tumor and virus-infected cells. We previously identified the NKG2D haplotypes in the natural killer gene complex region on chromosome 12p. Two major haplotype alleles, LNK1 and HNK1, were closely related to low and high natural cytotoxic activity phenotypes, respectively. Furthermore, the haplotype of HNK1/HNK1 has revealed a decreased risk of cancer compared with LNK1/LNK1. In the present study, using flow cytometry, we evaluated the functional effects of NKG2D haplotypes and five htSNPs in terms of the cell-surface expression of NKG2D protein on NK and CD8 T cells of peripheral blood among 732 atomic-bomb survivors. NKG2D expression on NK cells showed significant increases, in the order of LNK1/LNK1, LNK1/HNK1 and HNK1/HNK1 haplotypes (p for trend=0.003), or with major homozygous, heterozygous, and minor homozygous genotypes for individual htSNPs (p for trend=0.02-0.003). The same trend was observed for NKG2D expression on CD8 T cells. Our findings indicate that the NKG2D haplotypes are associated with the expression levels of NKG2D protein on NK and CD8 T cells, resulting in inter-individual variations in human cytotoxic response. PMID:22507622

  12. Medical examination of A-bomb survivors on Nagasaki A-bomb Casualty

    Energy Technology Data Exchange (ETDEWEB)

    Tagawa, Masuko [Nagasaki Atomic Bomb Casualty Council (Japan)

    1996-03-01

    Medical examination of A-bomb survivors was described and discussed on history, time change of examinee number, action for subjects not examined, change of prevalence, cancer examination, examination for the second generation, and education and enlightenment. Free examination of the survivors was begun in 1953 and the present casualty was made in 1958 on the law for medical care for the survivors. Systematic examination started from 1967 and the examination for the 2nd generation, from 1974. Cancer examination was from 1988. The number of the survivors was the maximum of 82,439 in 1974 and decreased to 61,388 in 1994, when the actual number of examinees, which being rather settled recently, was 32,294 and their average age was 64 y. The examination is done by tour or at the Center. Subjects receive the information of the examination twice by mail. Hematopoietic diseases like anemia, hepatic ones, metabolic and endocrinic ones like diabetes, renal impairment and others (mostly hyperlipidemia) are increasing recently. The number of examinees for cancer is increasing. Lung cancer is examined by the direct roentgenography, gastric cancer by transillumination, and other cancers like myeloma, those in large bowel, uterus and mammary gland, by the respective suitable methods. Health education and enlightenment have been conceivably effective. (H.O.)

  13. Medical examination of A-bomb survivors on Nagasaki A-bomb Casualty

    International Nuclear Information System (INIS)

    Medical examination of A-bomb survivors was described and discussed on history, time change of examinee number, action for subjects not examined, change of prevalence, cancer examination, examination for the second generation, and education and enlightenment. Free examination of the survivors was begun in 1953 and the present casualty was made in 1958 on the law for medical care for the survivors. Systematic examination started from 1967 and the examination for the 2nd generation, from 1974. Cancer examination was from 1988. The number of the survivors was the maximum of 82,439 in 1974 and decreased to 61,388 in 1994, when the actual number of examinees, which being rather settled recently, was 32,294 and their average age was 64 y. The examination is done by tour or at the Center. Subjects receive the information of the examination twice by mail. Hematopoietic diseases like anemia, hepatic ones, metabolic and endocrinic ones like diabetes, renal impairment and others (mostly hyperlipidemia) are increasing recently. The number of examinees for cancer is increasing. Lung cancer is examined by the direct roentgenography, gastric cancer by transillumination, and other cancers like myeloma, those in large bowel, uterus and mammary gland, by the respective suitable methods. Health education and enlightenment have been conceivably effective. (H.O.)

  14. Lung cancer incidence among A-bomb survivors in Hiroshima and Nagasaki, 1950 - 80

    International Nuclear Information System (INIS)

    The incidence of lung cancer during 1950 - 80 in a cohort of Japanese atomic bomb survivors and controls was investigated. A total of 1,057 cases were identified; 608 of these diagnoses were based on some form of histopathologic examination, and 442 were confirmed by the present investigators. The distributions of histological types varied significantly between the sexes (p < .001), with adenocarcinoma more frequent among women and epidermoid and small cell carcinoma more frequent among men. The distributions of primary sites did not differ significantly between the sexes. The relative risk (RR) of lung cancer increased significantly with A-bomb radiation dose (p < .0001); based on tentative 1965 dose estimates as revised in 1978 (T65DR) and a linear RR model, the estimated RR at 100 rad (± SE) is 1.41 ± 0.09. Among Hiroshima survivors the women experienced radiation-related excess RR nearly twice as great as men (p = .06). RR increased with decreasing age at the time of bombing (p = .07), and after allowing for this effect, there was no significant evidence that RR varied systematically with attained age. Small cell carcinoma displayed somewhat greater sensitivity to radiation than did adenocarcinoma or epidermoid carcinoma; however the variation between the histology-specific RR functions was not statistically significant (p = .44). (author)

  15. Hurricane Ike versus an Atomic Bomb

    Science.gov (United States)

    Pearson, Earl F.

    2013-01-01

    The destructive potential of one of nature's most destructive forces, the hurricane, is compared to one of human's most destructive devices, an atomic bomb. Both can create near absolute devastation at "ground zero". However, how do they really compare in terms of destructive energy? This discussion compares the energy, the…

  16. Age and dose related alteration of in vitro mixed lymphocyte culture response of blood lymphocytes from A-bomb survivors

    International Nuclear Information System (INIS)

    The responsiveness of peripheral blood lymphocytes to allogenic antigens in mixed lymphocyte culture (MLC) was measured in 139 atomic-bomb survivors. The study revealed a significant decrease in MLC response with increasing dose of previous radiation exposure. This decline was marked in the survivors who were older than 15 at the time of the bomb (ATB). The results suggest a possible relationship between the recovery of T-cell-related function and the thymic function which processes mature T cells for the immune system. Thus it may be that in the advanced age ATB group, the thymus function had started to involute, allowing less recovery of T-cell function compared to young survivors who had adequate processing T-cell activity

  17. Outline on populations of Nagasaki A-bomb survivors and sex ratio in their children

    International Nuclear Information System (INIS)

    On the basis of file delivered together with A-bomb surrivor's health Cards in Nagasaki, statistical management was performed on a mass of A-bomb survivors. The number of A-bomb survivors in a mass was 97,032. A family investigation by census registration was performed on 2,547 of A-bomb survivor group (the distance from the center of explosion recorded on cards was within 1.5 km) and 2,791 of its control group. As to 2,547 of A-bomb survivor group, each exposure place was determined, the distance from the center of explosion was measured again, and exposure dose was presumed. The mean exposure dose of A-bomb survivor group was 577 rad in male, and 681 rad in female. By adding A-bomb survivor group to the control group, 4,452 pairs of marriage were confirmed by census registration, and the number of their children was 10,073. With respect to changes of sex ratio, in case of exposed mother, it was expected theoretically that the number of male would decrease together with an decrease of dose, but an opposite change was recognized in a result of the investigation. A result in case of exposed father showed an increase of the male number although not significantly and a change towards the expected direction. (Tsunoda, M.)

  18. The Manhattan Project: Making the atomic bomb

    Energy Technology Data Exchange (ETDEWEB)

    Gosling, F.G.

    1994-09-01

    This article is a short history of the origins and development of the American atomic bomb program during World War II. Beginning with the scientific developments of the pre-war years, the monograph details the role of US government in conducting a secret, nationwide enterprise that took science from the laboratory and into combat with an entirely new type of weapon. The monograph concludes with a discussion of the immediate postwar period, the debate over the Atomic Energy Act of 1946, and the founding of the Atomic Energy Commission.

  19. The French atomic bomb tests

    Directory of Open Access Journals (Sweden)

    N. K. Nayak

    1961-10-01

    Full Text Available This article summarizes the details of two French Atomic Tests. Both were carried out at Hamoudia in the vicinity of Reggane (Sahara, the first on 13th of February 1960 and the second on the 1st April 1960. The nuclear explosive used in both cases was plutonium. In the first test the device was placed on the top of a tower of about 100 meters high whereas in the second test it was placed in a prefabricated shed. According to unofficial reports, the yields of the two tests were about 60Kt and less than 20Kt respectively.

  20. Cancer risk estimation from the A-bomb survivors

    International Nuclear Information System (INIS)

    Generalizations regarding radiogenic cancer risks from the A-bomb survivor data of the Radiation Effects Research Foundation involve a large number of well-identified uncertainties and approximations. These include extrapolation to low doses and dose rates, projections in time, sampling variation, the quality of the data, extrapolation to other populations, and the use of simplifying conventions. This paper discusses some of these issues, with emphasis on the first three. Results are given regarding the maximum 'linear-quadratic' curvature consistent with these data, taking into account uncertainties in individual exposure estimates. Discussion is given regarding use of relative risk models and projection of lifetime risks, emphasizing results for those who were old enough at exposure to have been followed up for a major part of their lives by now, and stressing the speculative aspects of conclusions about those exposed as children. Combining these results, and brief discussion of other uncertainties itemized above, comment is made on the evolution of risk estimates over the past 15 years. (author)

  1. Chain reaction. History of the atomic bomb

    International Nuclear Information System (INIS)

    Henri becquerel tracked down in 1896 a strange radiation, which was called radioactivity by Marie Curie. In the following centuries German scientists Max Planck, Albert Einstein and Werner Heisenberg presented fundamental contributions to understand processes in the atomic nucleus. At Goettingen, center of the international nuclear physics community, the American student J. Robert Oppenheimer admit to this physical research. In the beginning of 1939 the message of Otto Hahns' nuclear fission electrified researchers. The first step, unleashing atomic energy, was done. A half year later the Second World War begun. And suddenly being friend with and busily communicating physicians were devided into hostile power blocs as bearers of official secrets. The author tells in this exciting book the story of the first atomic bomb as a chain reaction of ideas, discoveries and visions, of friendships, jealousy and intrigues of scientists, adventurers and genius. (orig./GL)

  2. Greetings: 50 years of Atomic Bomb Casualty Commission-Radiation Effects Research Foundation studies.

    Science.gov (United States)

    Shigematsu, I

    1998-05-12

    The Atomic Bomb Casualty Commission was established in Hiroshima in 1947 and in Nagasaki in 1948 under the auspices of the U.S. National Academy of Sciences to initiate a long-term and comprehensive epidemiological and genetic study of the atomic bomb survivors. It was replaced in 1975 by the Radiation Effects Research Foundation which is a nonprofit Japanese foundation binationally managed and supported with equal funding by the governments of Japan and the United States. Thanks to the cooperation of the survivors and the contributions of a multitude of scientists, these studies flourish to this day in what must be the most successful long-term research collaboration between the two countries. Although these studies are necessarily limited to the effects of acute, whole-body, mixed gamma-neutron radiation from the atom bombs, their comprehensiveness and duration make them the most definitive descriptions of the late effects of radiation in humans. For this reason, the entire world relies heavily on these data to set radiation standards. As vital as the study results are, they still represent primarily the effects of radiation on older survivors. Another decade or two should correct this deficiency and allow us to measure definitively the human risk of heritable mutation from radiation. We look to the worldwide radiation and risk community as well as to the survivors who have contributed so much to what has been done already to accomplish this goal. PMID:9576897

  3. Influence on social life of atomic bomb, chapter 3

    International Nuclear Information System (INIS)

    Atomic bombs, for the first time in human history, were dropped on Hiroshima in August 6, and on Nagasaki on August 9, 1945. Though the powers of these bombs were far small as compared with those of present day nuclear weapons, the atomic bombs claimed many lives instantaneously, damaged human bodies, and destroyed all objects, annihilating the urban areas. Even today, the dreadful consequences of the bombings still remain in both body and mind of the victims. Meanwhile, the experiences of atomic bomb disasters are fading constantly. In order to maintain the vivid information, in Part 3 ''Influence on social life'', the following matters are described: relations of the atomic bombings to society; destroyed societies such as disruption of regional societies and loss of wealth; life of the sufferers such as occupation, marriage, hardships of life, orphans, livelihood variation, and suffering of foreigners; and mental process of the sufferers. (J.P.N.)

  4. Exposure to an atomic bomb explosion is a risk factor for in-hospital death after esophagectomy to treat esophageal cancer.

    Science.gov (United States)

    Nakashima, Y; Takeishi, K; Guntani, A; Tsujita, E; Yoshinaga, K; Matsuyama, A; Hamatake, M; Maeda, T; Tsutsui, S; Matsuda, H; Ishida, T

    2015-01-01

    Esophagectomy, one of the most invasive of all gastrointestinal operations, is associated with a high frequency of postoperative complications and in-hospital mortality. The purpose of the present study was to determine whether exposure to the atomic bomb explosion at Hiroshima in 1945 might be a preoperative risk factor for in-hospital mortality after esophagectomy in esophageal cancer patients. We thus reviewed the outcomes of esophagectomy in 31 atomic bomb survivors with esophageal cancer and 96 controls (also with cancer but without atomic bomb exposure). We compared the incidences of postoperative complications and in-hospital mortality. Of the clinicopathological features studied, mean patient age was significantly higher in atomic bomb survivors than in controls. Of the postoperative complications noted, atomic bomb survivors experienced a longer mean period of endotracheal intubation and higher incidences of severe pulmonary complications, severe anastomotic leakage, and surgical site infection. The factors associated with in-hospital mortality were exposure to the atomic bomb explosion, pulmonary comorbidities, and electrocardiographic abnormalities. Multivariate analysis revealed that exposure to the atomic bomb explosion was an independent significant preoperative risk factor for in-hospital mortality. Exposure to the atomic bomb explosion is thus a preoperative risk factor for in-hospital death after esophagectomy to treat esophageal cancer. PMID:24224952

  5. The genetic effects of the atomic bombs

    International Nuclear Information System (INIS)

    Studies on the genetic effects of the atomic bombs detonated over Hiroshima and Nagasaki have been in progress since 1946. The indicators of potential genetic damage in the children of exposees which have been employed are: (1) untoward pregnancy outcomes (major congenital defect and/or stillbirth and/or neonatal death), (2) death of liveborn infants prior to average age 28.8 years, (3) cancer of onset prior to age 20, (4) sex chromosome aneuploidy, (5) mutations affecting protein electrophoretic mobility and/or activity, (6) chromosomal reciprocal translocations, (7) sex-ratio in the children of exposed mothers, and (8) physical development at birth, at 9-months, and at school age. There is no statistically significant effect of parental exposure to the bombs on any of these indicators. The net regression of indicator(s) on dose is, however, positive. On the basis of these regressions and assumptions concerning the contribution of spontaneous mutation to the indicator values in the controls, the gametic doubling dose of acute ionizing radiation under these circumstances is estimated to be 2 Sv. With a dose rate factor of 2, which seems appropriate to these circumstances, the doubling dose for chronic radiation is placed at 4 Sv. This is a substantially higher estimate than previous extrapolations to man from murine experiments

  6. Why the USA dropped atomic bombs on Japanese cities

    International Nuclear Information System (INIS)

    Why did the USA use atomic bombs on Japanese cities? Because, by summer 1945, the earlier morality that said you should not kill non-combatants had been chipped away, then eroded, and ultimately destroyed by World War II. After Hitler's viciousness, after the Japanese rape of Nanjing, after the killings in Manila, after the savagery through Asia, after Dresden, after Hamburg, after Tokyo, Osaka, Kobe, Nagoya - over sixty Japanese cities had been bombed before Hiroshima, Hiroshima was inevitable, easy, comfortable, virtually automatic. The transformation was not the use of bomb, but the bombing of non-combatants - massively, intentionally. There was probably a desire to revenge, as well. In addition, there was an expectation that the bombs used on japan would also intimidate the Soviet Union but that was not crucial. Any nation that had the capacity would have used the bomb in righteousness and comfort, self-conceived dignity, amid popular applause from its electorate people

  7. Personality and Major Depression among Directly Exposed Survivors of the Oklahoma City Bombing

    Directory of Open Access Journals (Sweden)

    Carol S. North

    2012-01-01

    Full Text Available Background. Few disaster studies have specifically examined personality and resilience in association with disaster exposure, posttraumatic stress disorder (PTSD, and major depression. Methods. 151 directly-exposed survivors of the Oklahoma City bombing randomly selected from a bombing survivor registry completed PTSD, major depression, and personality assessments using the Diagnostic Interview Schedule for DSM-IV and the Temperament and Character Inventory, respectively. Results. The most prevalent postdisaster psychiatric disorder was bombing-related PTSD (32%; major depression was second in prevalence (21%. Bombing-related PTSD was associated with the combination of low self-directedness and low cooperativeness and also with high self-transcendence and high harm avoidance in most configurations. Postdisaster major depression was significantly more prevalent among those with (56% than without (5% bombing-related PTSD (P<.001 and those with (72% than without (14% predisaster major depression (P<.001. Incident major depression was not associated with the combination of low self-directedness and low cooperativeness. Conclusions. Personality features can distinguish resilience to a specific life-threatening stressor from general indicators of well-being. Unlike bombing-related PTSD, major depression was not a robust marker of low resilience. Development and validation of measures of resilience should utilize well-defined diagnoses whenever possible, rather than relying on nonspecific measures of psychological distress.

  8. Teaching and Learning Multiple Perspectives: The Atomic Bomb.

    Science.gov (United States)

    Doppen, Frans H.

    2000-01-01

    Explores how historical empathy can give students a richer understanding of the past, focusing on the development of the students' historical understanding through an analysis of 18 documents on President Truman's decision to use the atomic bomb against Japan. (CMK)

  9. The children of parents exposed to atomic bombs

    International Nuclear Information System (INIS)

    The data collected in Hiroshima and Nagasaki during the past 40 years on the children of survivors of the atomic bombings and on the children of a suitable control population are analyzed on the basis of the newly revised estimates of radiation doses. No statistically significant effects emerge with respect to eight different indicators. Since, however, it may confidently be assumed some mutations were induced, we have taken the data at face value and calculated the minimal genetic doubling doses of acute radiation for the individual indicators at various probability levels. An effort has also been made to calculate the most probable doubling dose for the indicators combined. The latter value is between 1.7 and 2.2 Sv. It is suggested the appropriate figure for chronic radiation would be between 3.4 and 4.5 Sv. These estimates suggest humans are less sensitive to the genetic effects of radiation than has been assumed on the basis of past extrapolations from experiments with mice. (author) 75 refs

  10. Preleukemia. Late and latent hematologic effects of atomic bomb irradiation in the Japanese

    International Nuclear Information System (INIS)

    Chromosome aberrations seem to be one of the most conspicuous residual abnormalities recognizable in radiation-exposed persons for many years after exposure. Knowledge of the biological significance of these abnormalities seems to be necessary for an understanding of the effects of radiation on humans, especially in relation to possible leukemic development. Cytological and cytogenetic studies were performed on the bone marrow cells in atomic bomb-exposed patiens who had prolonged periods of blood disorders which terminated in acute leukemia (Group 1, 6 cases), which had not done so (Group II, 6 cases), and survivors who were in apparent good health (Group III, 95 cases). Cytologic and cytogenetic abnormalities of bone marrow cells found among the atomic bomb survivors were also observed in the bone marrow smears from patients with prolonged periods of blood disorders and without a history of atomic bomb exposure or therapeutic irradiation. The persistent chromosome aberrations and morphological disorders, regardless of a history of radiation exposure, may give some suggestions concerning the diagnosis of the preleukemic state and also give some clues to help solve the problems of leukemogenesis

  11. Follow-up studies on A-bomb survivors: implications for radiological protection

    International Nuclear Information System (INIS)

    A-bomb survivor data are the principal basis for risk estimates for late somatic and genetic effects of radiation on man. The data concern radiation delivered at high dose rate and the risk estimates are dominated by persons with doses (kerma) of more than 100 rads. The estimates, therefore, may not be applicable to low doses received at low dose rates, where some advocate use of a dose-rate reduction factor of at least two for carcinogenesis. In contrast with dose-rate factors, little attention has been given to individual factors such as age. Even after more than 35 years, the experience of only the oldest A-bomb survivors (aged over 50 in 1945) is essentially complete. It appears, however, that the risk of carcinogenesis may depend upon age at exposure and that relative risk may be a more appropriate measure than absolute risk. Limits for occupational or population exposures were not developed on the basis of risk estimates; such estimates can, however, be used to calculate the possible consequences of exposure standards. In contrast to carcinogenesis, which has been shown clearly in the data on A-bomb survivors, and despite the appearance of chromosome aberrations, no evidence of radiation-induced mutations in the children of survivors has yet been detected

  12. The Manhattan Project: Making the Atomic Bomb. 1999 edition.

    Science.gov (United States)

    Gosling, F. G.

    1999-01-01

    "The Manhattan Project: Making the Atomic Bomb" is a short history of the origins and development of the American atomic bomb program during World War II. Beginning with the scientific developments of the pre-war years, the monograph details the role of the United States government in conducting a secret, nationwide enterprise that took science from the laboratory and into combat with an entirely new type of weapon. The monograph concludes with a discussion of the immediate postwar period, the debate over the Atomic Energy Act of 1946, and the founding of the Atomic Energy Commission.

  13. The Manhattan Project: Making the Atomic Bomb. 1999 edition.

    Energy Technology Data Exchange (ETDEWEB)

    Gosling, F.G.

    1999-01-01

    ``The Manhattan Project: Making the Atomic Bomb`` is a short history of the origins and development of the American atomic bomb program during World War II. Beginning with the scientific developments of the pre-war years, the monograph details the role of the United States government in conducting a secret, nationwide enterprise that took science from the laboratory and into combat with an entirely new type of weapon. The monograph concludes with a discussion of the immediate postwar period, the debate over the Atomic Energy Act of 1946, and the founding of the Atomic Energy Commission.

  14. Serum ferritin and stomach cancer risk among A-bomb survivors

    International Nuclear Information System (INIS)

    Using stored serum samples collected from 1970-72 and/or from 1977-79, serum ferritin, transferrin, and ceruloplasmin levels were immunologically determined for 233 stomach cancer and 84 lung cancer cases diagnosed from 1973-83 and for 385 matched controls from a fixed population of Hiroshima and Nagasaki atomic bomb survivors. Elevated stomach cancer risk was associated with low serum ferritin levels, with more than a threefold excess among those in the lowest quintile as compared to the highest ferritin quintile. The average serum ferritin concentration was 8% lower in the stomach cancer cases than in the controls. Risk did not vary with the time between blood collection and stomach cancer onset, remaining high among those with low ferritin levels five or more years before cancer diagnosis. Low ferritin combined with achlorhydria, diagnosed about 10 years before the blood collection and up to 25 years before cancer diagnosis, was an exceptionally strong marker of increased stomach cancer risk. No effect of transferrin or ceruloplasmin independent of ferritin was observed on gastric cancer risk. Lung cancer risk was not related to these three serum proteins. (author)

  15. The development of fetal dosimetry and its application to A-bomb survivors exposed in utero.

    Science.gov (United States)

    Chen, Jing

    2012-03-01

    The cohort of the atomic bomb survivors of Hiroshima and Nagasaki comprises the major basis for investigations of health effects induced by ionising radiation in humans. To study the health effects associated with radiation exposure before birth, fetal dosimetry is needed if significant differences exist between the fetal absorbed dose and the mother's uterine dose. Combining total neutron and gamma ray free-in-air fluences at 1 m above ground with fluence-to-absorbed dose conversion coefficients, fetal doses were calculated for various exposure orientations at the ground distance of 1500 m from the hypocentres in Hiroshima and Nagasaki. The results showed that the mother's uterine dose can serve as a good surrogate for the dose of the embryo and fetus in the first trimester. However, significant differences exist between doses of the fetus of different ages. If the mother's uterine dose were used as a surrogate, doses to the fetus in the last two trimesters could be overestimated by more than 20 % for exposure orientations facing towards and away from the hypocentre while significantly underestimated for lateral positions relative to the hypocentre. In newer fetal models, the brain is modelled for all fetal ages. Brain doses to the 3-month fetus are generally higher than those to an embryo and fetus of other ages. In most cases, brain absorbed doses differ significantly from the doses to the entire fetal body. In order to accurately assess radiation effects to the fetal brain, it is necessary to determine brain doses separately. PMID:21816724

  16. Late effect of atomic bomb radiation on myeloid disorders: leukemia and myelodysplastic syndromes.

    Science.gov (United States)

    Tsushima, Hideki; Iwanaga, Masako; Miyazaki, Yasushi

    2012-03-01

    Leukemia was the first malignancy linked to radiation exposure in atomic bomb survivors. Clear evidence of the dose-dependent excess risk of three major types of leukemia (acute lymphocytic leukemia, acute myeloid leukemia [AML], and chronic myeloid leukemia) was found, especially in people exposed at young ages. Such leukemia risks were at their highest in the late 1950s, and declined gradually thereafter over the past 50 years. Findings from recent risk analyses, however, suggest the persistence of AML risk even after 1990, and evidence of increased risk of myelodysplastic syndromes (MDS) due to atomic bomb radiation has recently been shown. High-risk MDS and forms involving complex chromosomal aberrations were found to be much more frequent in people exposed to higher radiation doses. These lines of epidemiological evidence suggest that the risk of radiation-induced hematological malignancies has persisted for six decades since the initial exposure. PMID:22370711

  17. Clinical survey of blood dyscrasias among Hiroshima A-bomb survivors by periodical health examination, (6)

    International Nuclear Information System (INIS)

    Serum ferritin was determined in A-bomb survivors, and its significance was evaluated. A low-ferritin group included many of the females under the age of 50, who mostly had iron deficient anemia. A high-ferritin group included many older-aged A-bomb survivors who had secondary anemia due to hemochromatosis, paroxismal nocturnal hemoglobinuria (PNH), and multiple myeloma. Secondary anemia due to hemochromatosis, PNH, leukemia, and sideroblastic anemia was detected in those who were old and had underlying moderate or severe anemia with a high ferritin level. As the results of this investigation, blood examination combined with serum ferritin determination is valuable for diagnosis of anemia and detection of underlying diseases. (Ueda, J.)

  18. Radiation dose, reproductive history, and breast cancer risk among Japanese A-bomb survivors

    International Nuclear Information System (INIS)

    Excess risk of female breast cancer is among the most comprehensively documented late effects of exposure to substantial doses of ionizing radiation, based on studies of medically irradiated populations and the survivors of the A-bombings of Hiroshima and Nagasaki. This study looks at the interaction of dose with epidemiological factors like age at first full-term pregnancy and family history of breast cancer, most closely associated with risk in epidemiological studies of non-irradiatied populations. 1 fig., 2 tabs

  19. Radiation dose, reproductive history, and breast cancer risk among Japanese A-bomb survivors

    Energy Technology Data Exchange (ETDEWEB)

    Land, C.E. [National Cancer Institute, Bethesda, MD (United States)

    1992-06-01

    Excess risk of female breast cancer is among the most comprehensively documented late effects of exposure to substantial doses of ionizing radiation, based on studies of medically irradiated populations and the survivors of the A-bombings of Hiroshima and Nagasaki. This study looks at the interaction of dose with epidemiological factors like age at first full-term pregnancy and family history of breast cancer, most closely associated with risk in epidemiological studies of non-irradiatied populations. 1 fig., 2 tabs.

  20. Lessons from the atomic bomb about secondary MDS.

    Science.gov (United States)

    Hata, Tomoko; Imanishi, Daisuke; Miyazaki, Yasushi

    2014-12-01

    Myelodysplastic syndromes (MDSs) is a hematological neoplasm defined by ineffective hematopoiesis, dysplasia of hematopoietic cells, and risk of progression to acute leukemia. MDS occurs as de novo or secondary, and chemoradiotherapy for cancers is thought to increase the risk of MDS among patients. Recently, an epidemiological study for MDS among A-bomb survivors was performed, and it clearly demonstrated that the exposure to external radiation significantly increased the risk of MDS. Precise epidemiological data among survivors have revealed important clinical factors related to the risk of leukemias. In this review, by comparing data for secondary MDS and leukemia/MDS among survivors, several factors which would affect the risk of MDS, especially secondary MDS, are discussed. PMID:25240475

  1. Is Einstein the Father of the Atomic Bomb

    Science.gov (United States)

    Lustig, Harry

    2009-05-01

    Soon after the American atomic bombs were dropped on Hiroshima and Nagasaki, the notion took hold in the popular mind that Albert Einstein was ``the father of the bomb.'' The claim of paternity rests on the belief that E=mc2 is what makes the release of enormous amounts of energy in the fission process possible and that the atomic bomb could not have been built without it. This is a misapprehension. Most physicists have known that all along. Nevertheless in his reaction to the opera Dr. Atomic, a prominent physicist claimed that Einstein's discovery that matter can be transformed into energy ``is precisely what made the bomb possible.'' In fact what makes the fission reaction and one of its applications,the atomic bomb, possible is the smaller binding energies of fission products compared to the binding energies of the nuclei that undergo fission.The binding energies of nuclei are a well understood consequence of the numbers and arrangements of protons and neutrons in the nucleus and of quantum-mechanical effects. The realization that composite systems have binding energies predates relativity. In the 19th century they were ascribed to potential and other forms of energy that reside in the system. With Einstein they became rest mass energy. While E=mc2 is not the cause of fission, measuring the masses of the participants in the reaction does permit an easy calculation of the kinetic energy that is released.

  2. Perspectives on radiation dose estimates for A-bomb survivors

    Energy Technology Data Exchange (ETDEWEB)

    Loewe, W.E.

    1986-12-01

    Four decades after the actual events, quantitative characterization of the radiation fields at Hiroshima and Nagasaki continues to be sought, with high accuracy a goal justified by the unique contribution to radiation protection standards that is represented by the medical records of exposed survivors. The most recent effort is distinguished by its reliance on computer modeling and concomitant detail, and by its decentralized direction, both internationally and internally to the US and Japan, with resultant ongoing peer review and wide scope of inquiry. A new system for individual dose estimation has been agreed upon, and its scientific basis has been elaborated in the literature as well as in a comprehensive treatise to be published in the Spring of 1987. In perspective, this new system appears to be an unusually successful achievement that offers the expectation of reliable estimates with the desired accuracy. Some aspects leading to this expectation, along with a caveat, are discussed here. 4 refs., 8 figs., 3 tabs.

  3. A study of sibling leukemia in the second generations of A-bomb survivors

    International Nuclear Information System (INIS)

    Although the sibling leukemia (SL) is very rare, it is known in 4 families living in Osaka and Hiroshima, of which mothers are A-bomb survivors (2 exposed in Hiroshima/2 in Nagasaki). This study was performed on the 8 cases of SL to examine factors concerned with SL morbidity by comparison with SL in families unrelated to A-bomb exposure. Subjects were 4 cases of SL in Osaka, 4 cases in Hiroshima, and comparative 28 cases of age <20 y in 13 families (1930-1974) in a textbook published in 1979. The SL cases from mothers exposed at ages of 10-20 y were 5 males/3 females, and died at ages of 6-17 y (av. 11 y) due to acute, myeloid/monocytic leukemia. Three mothers' exposures were due to entrance in the City just/1 or 10 days after explosion and 2 mothers had lived in the black rain regions of either Hiroshima or Nagasaki. Comparisons were made on sex, type of L, age at death, parents' exposure, family composition, complication, and parents' consanguineous marriage. Findings of SL specific in the second generations of A-bomb survivors were from exposed mothers, and were mostly myeloid (monocyte) type leukemia, suggesting the effect of exposure. These facts may suggest that oocytes/ovula are of high sensitivity to internal exposure or low dose exposure. (T.T.)

  4. An epidemiological study in Nagasaki City of malignant lymphoma and the atomic bomb exposure

    Energy Technology Data Exchange (ETDEWEB)

    Higami, Yoshiichi; Shimokawa, Isao; Iwasaki, Keisuke; Matsuo, Takeshi; Ikeda, Takayoshi (Nagasaki Univ. (Japan). School of Medicine); Mine, Mariko

    1993-05-01

    The incidence of primary site and histological type of malignant lymphoma and the relationship to the atomic bomb exposure in Nagasaki City were investigated in a population of age over 30 years during 1973 to 1982. Of 365 cases (male 207, female 158) of malignant lymphoma reported, 142 (male 66, female 76) had the atomic bomb exposure. No significant difference in incidence of malignant lymphoma was found between the exposed and non-exposed groups. Primary sites of non-Hodgkin lymphoma were: lymph nodes; male exposed, 66; non-exposed, 67%; female exposed, 50%; non-exposed, 69%, gastrointestinal (G.I.) tract, male exposed, 14%; non-exposed, 11%; female exposed, 21%; non-exposed, 17%. histological reexamination of 232 cases according to the National Cancer Institute (USA) criteria yielded: diffuse large cell type, 27.2%; large cell immunoblastic type, 28.0%. No significant difference in these items was found between the exposed and the non-exposed groups. A comparison to the Hiroshma data revealed that an atomic bomb survivor does not show higher incidence in Nagasaki but in Hiroshima. (author).

  5. The development of fetal dosimetry and its application to a-bomb survivors exposed in utero

    International Nuclear Information System (INIS)

    The cohort of the atomic bomb survivors of Hiroshima and Nagasaki comprises the major basis for investigations of health effects induced by ionising radiation in humans. To study the health effects associated with radiation exposure before birth, fetal dosimetry is needed if significant differences exist between the fetal absorbed dose and the mother's uterine dose. Combining total neutron and gamma ray free-in-air fluences at 1 m above ground with fluence-to-absorbed dose conversion coefficients, fetal doses were calculated for various exposure orientations at the ground distance of 1500 m from the hypo-centres in Hiroshima and Nagasaki. The results showed that the mother's uterine dose can serve as a good surrogate for the dose of the embryo and fetus in the first trimester. However, significant differences exist between doses of the fetus of different ages. If the mother's uterine dose were used as a surrogate, doses to the fetus in the last two trimesters could be overestimated by more than 20 % for exposure orientations facing towards and away from the hypo-centre while significantly underestimated for lateral positions relative to the hypo-centre. In newer fetal models, the brain is modelled for all fetal ages. Brain doses to the 3-month fetus are generally higher than those to an embryo and fetus of other ages. In most cases, brain absorbed doses differ significantly from the doses to the entire fetal body. In order to accurately assess radiation effects to the fetal brain, it is necessary to determine brain doses separately. (author)

  6. Mortality statistics by causes of death among A-bomb survivors in Hiroshima prefecture, 1973 - 1977

    International Nuclear Information System (INIS)

    The standardized mortality ratios of A-bomb survivors in Hiroshima Prefecture between 1973 and 1977 were compared with those of non-exposed population in this prefecture. In the malignant neoplasms, the ratios for leukemia, liver, breast, lung, larynx, brain, bone, skin, uterus, bladder and colon were higher than non-exposed. Other than the neoplasms, the ratios for cirrhosis of liver, diabetes, hypertensive diseases and blood and blood-forming organs were higher than nonexposed, while those for heart diseases, cerebro-vascular diseases, senility, gastro-enteritis and accidents were lower than non-exposed. (author)

  7. Interpreting the Atomic Age: Scientific News Coverage of the Atomic Bomb in Representative Newspapers and Magazines.

    Science.gov (United States)

    Barwis, Gail L.

    A study examined the coverage of the scientific aspects of the atomic bomb in four representative newspapers (New York "Times," New York "Herald Tribune," Chicago "Daily Tribune," and Boston "Daily Globe") and in 14 general mass circulation magazines in the time period immediately following the dropping of the bomb. Among the conclusions of the…

  8. By emotion, no atomic bomb and no blackhole

    Science.gov (United States)

    Shin, Philip

    2011-10-01

    As to be, we glory to God and that is basic theology for christian. And I want to say that BE means just thinking. There is no clue of nature and no proposition to prove it. I just believe by feeling and emotion. I trust that it can be the physic really. As for me, I believe when there is atomic bomb, than anytime it has to blow out the world each time of we are living. So the atomic bomb we thinking is just accident and not by the atomic theory. Also when there is blackhole, than there must be the wall to block me forever and never to walk again. So there are no blackhole. And these two subject is the best two subject for the physic.

  9. Health effects of atomic-bomb radiation

    International Nuclear Information System (INIS)

    This review described carcinogenic and genetic effects of A-bomb radiation. Effects have been investigated on 120,000 exposed people for their life span, 20,000 for health examinations, 3,000 people exposed in the womb and 80,000 second-generations of the exposed people. Epidemiological data revealed the presence of carcinogenic effects: Cancer death amounted to 9% from 1950 to 1990. However, carcinogenic mechanism is unknown yet. Genetic effects have been studied from the points of lesion at birth, sex ratio, chromosome aberration, biochemical test and mortality rate of children of exposed people and, although the effects have been experimentally shown in animals, are not observed in those children. This may be derived from the fact that there are few people who were exposed to such a high dose as used experimentally (0.2 Sv exposure to people within 2.5 km diameter-area from the explosion point vs >3 Sv in animals). Data are presented in Research Foundation home page. (K.H.)

  10. Study on defense function of polymorphonuclear leukocytes in A-bomb survivors, 4

    International Nuclear Information System (INIS)

    Included in this study were 222 A-bomb survivors, consisting of the exposed group (104 exposed to 0.5-6.0 Gy estimated on the basis of T65 DR) and the non-exposed group (118 exposed to 0 Gy). Regarding superoxide anion production, such as O2-·CF and O2-·F, there were significant differences between the exposed and non-exposed groups. Chemotaxis, natural migration, and chemokinesis of polymorphonuclear leukocytes (PMN) tended to be increased in the exposed group. This was more marked in men than women. Chemotaxis, natural migration, and chemokinesis of PMN were significantly increased in A-bomb survivors aged 59 years or less (65.2±16.7 μml/45 min, 31.3±11.1, and 44.7±13.9, respectively) than those aged more than 59 years (59.5±18.5, 26.3±10.8, and 38.6±14.6, respectively). The group of patients aged 59 years or less tended to have higher values of O2-·CF and O2-·F. A significantly increased chemokinesis was associated with cigarette smoking. Regarding the other items, such as migration, chemotaxis, and superoxide anion production, the measurement values tended to be higher in the group of smokers than that of nonsmokers. (N.K.)

  11. The Rhetoric of "Unconditional Surrender" and the Decision to Drop the Atomic Bomb.

    Science.gov (United States)

    Hikins, James W.

    1983-01-01

    Analyzes the decision to drop the atomic bomb from a rhetorical point of view, arguing that the bombs were launched because of an American commitment to a particular rhetoric that focused on the propaganda slogan "unconditional surrender." (PD)

  12. Hot spring therapy of atomic bomb exposed patients, (9)

    International Nuclear Information System (INIS)

    The following description shows the statistics and the results of medical examinatin concerning the patients utilized Beppu Atomic Bomb Center from April, 1977, to March, 1978. Number of persons utilized the center was 3904, and 20285 man-days in total. Number of case treated there was 268. Number of diseases amounted to 442 of 66 sorts, excluding temporary of acute diseases such as acute entergastritis and cold diseases, etc. According to the report by the Ministry of Health and Welfare, atomic bomb-exposed persons show twice as much rate of incidence as normal persons, and owing to aging, many of them have more than two kinds of diseases. Among the diseases, 60 cases were hypertension, 32 heart disease, 30 knee-arthritis, 26 diabetes, 25 hepatitis, 23 spondylosis deformans, etc. Among 268 cases treated by hot spring therapy, 6 were totally cured, and 252 showed alleviation, while 10 showed no change. (Kobatake, H.)

  13. Surveys right after the atomic bombing and a relief squad

    International Nuclear Information System (INIS)

    An outline of four survey reports right after the atomic bombing in Nagasaki and Hiroshima is introduced. The report of Manhattan District Atomic Bomb Investigating Groups: The subjects of this survey were 900 inpatients in Nagasaki (for 16 days from September 20) and Hiroshima (for 5 days from October 3). Two hundreds and forty-nine patients (16%) died. In cases died without injury, the severe symptoms were alopecia, purpura, hemorrhage, oral cavity and pharynx lesion, vomiting, diarrhea and fever. The residual radioactivity measured at six weeks later was 6-25 roentgen in Hiroshima and 30-110 roentgen in Nagasaki (Nishiyama riverhead area). These values were lower than the predicted value from the clinical consequence. The report of Joint Commission for the Investigation of the Atomic Bomb: Following the above survey, about 6500 subjects were investigated both in Nagasaki and Hiroshima. Incidence of alopecia was investigated by shielded situation at a spot of 2.1 to 2.5 km from a blast center. It was 7.2% of outdoors (shielded: 7.3%, non-shielded: 17.4%) and 2.9% of indoors. The report of the Special Committee for Atomic Bomb Casualty Investigation and Research of the Scientific Research Council of Japan: General part of the report consists of medical part and physical part, and reports from each university were classified and listed in the supplement. Survey of Nagasaki Medical College (not in public): About 8000 subjects were investigated from October to December. Data were gathered up about lethality, time of death, injury and radiation sickness, etc. There was also autograph of a relief squad of the Nagasaki Medical College. (K.H.)

  14. Surveys right after the atomic bombing and a relief squad

    Energy Technology Data Exchange (ETDEWEB)

    Mine, Mariko [Nagasaki Univ. (Japan). School of Medicine

    1998-12-01

    An outline of four survey reports right after the atomic bombing in Nagasaki and Hiroshima is introduced. The report of Manhattan District Atomic Bomb Investigating Groups: The subjects of this survey were 900 inpatients in Nagasaki (for 16 days from September 20) and Hiroshima (for 5 days from October 3). Two hundreds and forty-nine patients (16%) died. In cases died without injury, the severe symptoms were alopecia, purpura, hemorrhage, oral cavity and pharynx lesion, vomiting, diarrhea and fever. The residual radioactivity measured at six weeks later was 6-25 roentgen in Hiroshima and 30-110 roentgen in Nagasaki (Nishiyama riverhead area). These values were lower than the predicted value from the clinical consequence. The report of Joint Commission for the Investigation of the Atomic Bomb: Following the above survey, about 6500 subjects were investigated both in Nagasaki and Hiroshima. Incidence of alopecia was investigated by shielded situation at a spot of 2.1 to 2.5 km from a blast center. It was 7.2% of outdoors (shielded: 7.3%, non-shielded: 17.4%) and 2.9% of indoors. The report of the Special Committee for Atomic Bomb Casualty Investigation and Research of the Scientific Research Council of Japan: General part of the report consists of medical part and physical part, and reports from each university were classified and listed in the supplement. Survey of Nagasaki Medical College (not in public): About 8000 subjects were investigated from October to December. Data were gathered up about lethality, time of death, injury and radiation sickness, etc. There was also autograph of a relief squad of the Nagasaki Medical College. (K.H.)

  15. Mutation, radiation, and species survival: The genetics studies of the Atomic Bomb Casualty Commission in Hiroshima and Nagasaki, Japan

    International Nuclear Information System (INIS)

    This is an analysis of the work of the Atomic Bomb Casualty Commission, an American agency which studied the effects of radiation on survivors of the atomic bombings at Hiroshima and Nagasaki, Japan, 1947-1975. Funded by the U.S. Atomic Energy Commission and directed by the National Academy of Sciences-National Research Council, the ABCC was the largest and longest medical study of the estimated 300,000 survivors. The morphological genetics study dominated the ABCCs first decade. James Neel and his principal collaborator William J. Schull tracked more than 76,000 pregnancies. Their results (1956) suggested the bombs radiation had no detectable impact on the offspring of survivors. Though geneticists knew that radiation caused heritable mutations in experimental organisms such as Drosophila, and believed it caused mutations in humans, the Neel-Schull findings were not a surprise. The practical difficulties of the study, and the relatively small increase in abnormal births to be expected, made a finding of significant effects unlikely. The Neel-Schull approach reflected the scientific debate over genetic load, and the Muller-Dobzhansky classical-balance controversy. Yet the findings also reflected the post-war debate over atomic energy and weapons testing. Many extra-scientific forces militated against a finding of positive effects at Hiroshima and Nagasaki. Negative findings were consistent with the needs of the Atomic Energy Commission, the State Department and the U.S. military. This dissertation explores how both the scientific debate about genetic load, and the political debate about atmospheric weapons testing, shaped this complex epidemiological study

  16. A method to detect low-level 63Ni activity for estimating fast neutron fluence from the Hiroshima atomic bomb.

    Science.gov (United States)

    Ito, Y; Shibata, T; Imamura, M; Shibata, S; Nogawa, N; Uwamino, Y; Shizuma, K

    1999-06-01

    The Hiroshima and Nagasaki atomic bombs resulted in the worst reported exposure of radiation to the human body. The data of survivors have provided the basis for the risk estimation for ionizing radiation, and thus are widely used as the basis of radiation safety. In this report we have studied a new method to detect the low-level 63Ni activity in copper samples in order to estimate the fast neutron fluence from the Hiroshima atomic bomb. Only 0.8 x 10(-3) Bq g(-1) of 63Ni is expected to be produced by the atomic bomb in a copper sample with the 63Cu(n, p)63Ni reaction at a distance of 500 m from the hypocenter. Our method has the required level of sensitivity for determination of the fast neutron fluence out to distances of at least 500 m, and perhaps as far as 1,000 m. We have already investigated and collected some bomb-irradiated copper samples for further study. PMID:10334579

  17. Reanalysis of interviewing study data in the health attitude survey of A-bomb survivors, etc

    International Nuclear Information System (INIS)

    The interviewing study data in the title were initially contained in the official request of Hiroshima City and Prefecture, which had been presented to MHLW (Ministry of Health, Labor and Welfare) in 2010, concerning spread of previously defined A-bomb exposed regions and were statistically reanalyzed based on the requirement of the consequent MHLW council. The data were originally derived from the questionnaire in 2008 about the health attitude survey by Hiroshima authorities, from which 892 survivors had received the interview together with self-writing, and answers of 869 parsons (524 males) were finally subjected to the present reanalysis. Measures of the interview involved the SF-36 (Medical Outcome Study Short Form 36-item Health Survey) for QOL, GHQ28 (General Health Questionnaire 28-item) for screening of neurosis/depression, and CAPS (Clinician Administered PTSD Scale) for diagnosis of PTSD (post traumatic stress disorder), etc. These measures were analyzed along with classes of A-bomb experience with adjustment factors of sex, age and income by multiple-/multivariate logistic-regression. It was found that measures were tended to be worse in groups experiencing the black rain without effects of adjustment factors, which was similar to groups experiencing the heavier rainfall; however, these results were statistically insignificant. (T.T.)

  18. The Last Act: The Atomic Bomb and the End of World War II.

    Science.gov (United States)

    Smithsonian Institution, Washington, DC. National Air And Space Museum.

    This text was to have been the script for the National Air and Space Museum's exhibition of the Enola Gay, focusing on the end of World War II and the decision of the United States to use of the atomic bomb. The Enola Gay was a B-29 aircraft that carried the atomic bomb dropped on Hiroshima, Japan, on August 6, 1945. The atomic bomb brought a…

  19. Reclassification of leukemia among A-bomb survivors by French-American-British (FAB) classification, 1

    International Nuclear Information System (INIS)

    The concordance rate for the French-American-British (FAB) reclassification diagnoses of atomic bomb-related cases of leukemia in Nagasaki was determined by a group of RERF hematologists and one of the members of the FAB cooperative gruop. The peripheral blood and/or bone marrow smears from 193 persons with leukemia or related disorder were reviewed. There was 85% agreement in the identification of leukemia types and subtypes. There was almost complete agreement for the diagnosis of non-FAB disorders (chronic myeloid leukemia and others) resulting in overall concordance of 88.2%. The conclusion from this remarkably high rate of concordance is that it is feasible to accurately apply the FAB classification system to the cases of A-bomb-related leukemia. These preliminary observations suggest that the previously established leukemia types for about a quarter of the cases of acute leukemia and related disorders should be changed. (author)

  20. One minute after the detonation of the atomic bomb: the erased effects of residual radiation.

    Science.gov (United States)

    Takahashi, Hiroko

    2009-01-01

    The U.S. Government's official narrative denies the effects of residual radiation which appeared one minute after the atomic bomb detonations in Hiroshima and Nagasaki. This paper explores declassified documents from the U.S. Atomic Energy Commission, the Atomic Bomb Casualties Commission, and others and shows that these documents actually suggested the existence of serious effects from residual radiation. PMID:20521423

  1. Origin of clonal chromosome aberrations observed in A-bomb survivors

    International Nuclear Information System (INIS)

    The purpose of the present study was to elucidate whether abnormal clone cells possessing chromosome aberrations observed in A-bomb survivors were derived from stem cells or peripheral lymphocytes. Subjects were 12 survivors in Hiroshima who were known to have abnormal clone cells in 3 - 12% peripheral lymphocyte count. Lymphocytes were isolated by Ficoll conray method, labeled by mouse monoclonal antibody against human CD45RA or CD45RO and then by the secondary antibody beads against mouse IgG. The respective cells were further divided to cells with (+) or without (-) magnetic label by magnetic cell separation method. Naive T cells were CD45RA+ and CD45RO- and memory T cells, - and +, respectively. Clonal chromosome abberations were analyzed by multiple FISH staining with DNA probes for biotin-FITC, Cy3, WCPOrange and FITC-labeled centromere. It was found that in 12 subjects 8 lymphocyte cases were stem cell origin and 5 cases, peripheral lymphocyte. The mean frequency of the former was found to be 7.6% in total lymphocyte count and the latter, 3.6%, indicating that the difference of origin was the cause of the difference of the frequency. Clonal cell growth can be related with re-arrangement of DNA by tumor- or tumor suppressor-gene.(K.H.)

  2. Reanalysis of cancer mortality in Japanese A-bomb survivors exposed to low doses of radiation: bootstrap and simulation methods

    Directory of Open Access Journals (Sweden)

    Dropkin Greg

    2009-12-01

    latency and risk from 10 mSv are obtained from the 0 - 20 mSv and 5 - 500 mSv subcohorts. Large and significant cancer risks for Japanese survivors exposed to less than 20 mSv external radiation from the atomic bombs in 1945 cast doubt on the ICRP recommended annual occupational dose limit.

  3. Genetic radiation effects of Hiroshima and Nagasaki atomic bombs

    Energy Technology Data Exchange (ETDEWEB)

    Srsen, S. (Komenskeho Univ., Bratislava (Czechoslovakia). Lekarska Fakulta)

    1984-05-01

    A group of researchers examined persons who had survived the Hiroshima and Nagasaki bombs and were irradiated and their progeny with the aim of getting an idea of the genetic effects of these explosions. Teratogenic effects are not discussed. In the lymphocytes of the peripheral blood of persons who had been exposed to high dose irradiation the researchers found a significant increase in chromosomal aberrations by conventional and more recent methods of chromosomal analysis. In parents who had survived the atomic holocaust there were no significant deviations as against the rest of the population in still births, neonatal defects, infant mortality, and mortality of first generation progeny, in neonate weight, the sex ratio, increased occurence of leukosis and chromosomal aberrations in their children. These negative findings in the first generation do not signify that there is no danger from atomic bomb blasts for human kind. They only indicate that the effects of radiation were too small to be found by routine methods or that the methods used were not suitable.

  4. Genetic radiation effects of Hiroshima and Nagasaki atomic bombs

    International Nuclear Information System (INIS)

    A group of researchers examined persons who had survived the Hiroshima and Nagasaki bombs and were irradiated and their progeny with the aim of getting an idea of the genetic effects of these explosions. Teratogenic effects are not discussed. In the lymphocytes of the peripheral blood of persons who had been exposed to high dose irradiation the researchers found a significant increase in chromosomal aberrations by conventional and more recent methods of chromosomal analysis. In parents who had survived the atomic holocaust there were no significant deviations as against the rest of the population in still births, neonatal defects, infant mortality, and mortality of first generation progeny, in neonate weight, the sex ratio, increased occurence of leukosis and chromosomal aberrations in their children. These negative findings in the first generation do not signify that there is no danger from atomic bomb blasts for human kind. They only indicate that the effects of radiation were to small to be found by routine methods or that the methods used were not suitable

  5. Study on specificity of leukemia among the second generation of A-bomb survivors

    International Nuclear Information System (INIS)

    The title specificity was studied and discussed for the leukemia (L) of 5 cases of the second generation who had lived in Osaka (Report 1977) in comparison with published statistic data of the second generation's 15 L cases in a life-span investigation (2003) and of 5,098 L cases in a nationwide report (2003). The A-bomb survivors were exposed in either Hiroshima or Nagasaki. The Osaka cases (4/5 boys) were morbid during 1958-1975, had acute L (myeloid L 3 cases, and unidentified type L 2) and died at ages of 10-19 y. Their parents were exposed to A-bomb directly (2 cases) or due to entrance in the city (3), and 1 father, 3 mothers and 1 couple of parents were exposed. Parent(s) in the life-span investigation were classified in high dose exposure (within 2 km distance from the city) and zero exposure (2.5 km afar from the city and other) groups. Their second generation (13/20 boys) were morbid during 1952-1969 at average age of 9.7 y (high dose group) and 8.3-7.2 y (zero group), and had acute myeloid L (8 cases), acute lymphocytic L (5) and other L. Exposure was to their 12 mothers, 4 fathers and 4 both parents. The nationwide statistics showed L of <18 years old pediatric patients (1986-2000) involving 56.7% boys, of morbid age peak of 3-4 y and of acute lymphocytic L in 68.8%. As above, it seemed that, in the second generation, their mothers were mostly exposed relative to fathers, the morbid sex ratio was higher in boys, morbid age was higher than general, and acute myeloid L was more frequent than general. L of the second generation thus seemed to be somehow specific, particularly in the higher age of morbidity and frequency of acute myeloid L. (T.T.)

  6. Role Playing: The Atomic Bomb and the End of World War II

    Science.gov (United States)

    Eggleston, Noel C.

    1978-01-01

    Describes how a role playing exercise can be used to teach students in a college level history course about the use of the atomic bomb in World War II. Information is presented on general use of role playing in history courses, objectives, questions to consider about use of the atomic bomb, and course evaluation. For journal availability, see so…

  7. Neutron-induced 63Ni activity and microscopic observation of copper samples exposed to the Hiroshima atomic bomb

    Science.gov (United States)

    Shizuma, Kiyoshi; Endo, Satoru; Shinozaki, Kenji; Fukushima, Hiroshi

    2013-05-01

    Fast neutron activation data for 63Ni in copper samples exposed to the Hiroshima atomic bomb are important in evaluating neutron doses to the survivors. Up to until now, accelerator mass spectrometry and liquid scintillation counting methods have been applied in 63Ni measurements and data were accumulated within 1500 m from the hypocenter. The slope of the activation curve versus distance shows reasonable agreement with the calculation result, however, data near the hypocenter are scarce. In the present work, two copper samples obtained from the Atomic bomb dome (155 m from the hypocenter) and the Bank of Japan building (392 m) were utilized in 63Ni beta-ray measurement with a Si surface barrier detector. Additionally, microscopic observation of the metal surfaces was performed for the first time. Only upper limit of 63Ni production was obtained for copper sample of the Atomic bomb dome. The result of the 63Ni measurement for Bank of Japan building show reasonable agreement with the AMS measurement and to fast neutron activation calculations based on the Dosimetry System 2002 (DS02) neutrons.

  8. Neutron-induced {sup 63}Ni activity and microscopic observation of copper samples exposed to the Hiroshima atomic bomb

    Energy Technology Data Exchange (ETDEWEB)

    Shizuma, Kiyoshi, E-mail: shizuma@hiroshima-u.ac.jp [Quantum Energy Applications, Department of Mechanical Science and Engineering, Graduate School of Engineering, Hiroshima University, Higashi-Hiroshima 739-8527 (Japan); Endo, Satoru [Quantum Energy Applications, Department of Mechanical Science and Engineering, Graduate School of Engineering, Hiroshima University, Higashi-Hiroshima 739-8527 (Japan); Shinozaki, Kenji [Materials Joining Science and Engineering, Department of Mechanical Science and Engineering, Graduate School of Engineering, Hiroshima University, Higashi-Hiroshima 739-8527 (Japan); Fukushima, Hiroshi [Materials Physics, Department of Mechanical Science and Engineering, Graduate School of Engineering, Hiroshima University, Higashi-Hiroshima 739-8527 (Japan)

    2013-05-01

    Fast neutron activation data for {sup 63}Ni in copper samples exposed to the Hiroshima atomic bomb are important in evaluating neutron doses to the survivors. Up to until now, accelerator mass spectrometry and liquid scintillation counting methods have been applied in {sup 63}Ni measurements and data were accumulated within 1500 m from the hypocenter. The slope of the activation curve versus distance shows reasonable agreement with the calculation result, however, data near the hypocenter are scarce. In the present work, two copper samples obtained from the Atomic bomb dome (155 m from the hypocenter) and the Bank of Japan building (392 m) were utilized in {sup 63}Ni beta-ray measurement with a Si surface barrier detector. Additionally, microscopic observation of the metal surfaces was performed for the first time. Only upper limit of {sup 63}Ni production was obtained for copper sample of the Atomic bomb dome. The result of the {sup 63}Ni measurement for Bank of Japan building show reasonable agreement with the AMS measurement and to fast neutron activation calculations based on the Dosimetry System 2002 (DS02) neutrons.

  9. Pathological study of atomic bomb survivors in Nagasaki district

    International Nuclear Information System (INIS)

    9331 autopsies were carried out in Nagasaki-district after the world war II, the chronological changes of the diseases incidences and the difference between exposed and unexposed cases were reviewed. Diseases of the circulatory system, hepatic diseases, and hematopoietic disorders were 14.8%, 13.5%, and 9.2%, respectively. The rate of malignant tumors from '76 to '77 was 67.7%, which was about 10% higher than the national average. In the hepatic lesions, cirrhosis and hepatoma were 1.7 and 1.4 times higher than the national average, respectively, and the highest rate was observed at the age of forties and fifties. For the hematopoietic disorders, leukemia was higher than malignant lymphoma until '60, which order became reverse after '61, and the incidences were 1.9 and 2.2 times higher than the national average, respectively, in '76. Chronological changes of disorders of the circulatory system had not been effected by exposure. (Nakanishi, T.)

  10. Effects of radiation on aging in atomic bomb survivors

    International Nuclear Information System (INIS)

    Promotion of aging was studied on women over the age of 40 years exposed within 1.4 km from the center of the explosion in Nagasaki in whom exposure doses were proved to be over 100 rad (a exposed group). Women exposed over 2.5 km whose ages were the same as those of the exposed group were selected as controls. The age of the exposed group was estimated from stepwise regression equation based on the measurement of hair, grip strength, systolic blood pressure, an amount of potassium in the whole body, and erythrocyte count, which changed remarkably with time. The estimated age of the exposed group was over one year older than that of controls. Especially, mean estimated age of the exposed group in their forties (the age at the time of exposure, teens) was 1.4 year older than the actual age, which suggests that radiation promote aging. (Tsunoda, M.)

  11. Statistical analysis of the main diseases among atomic bomb survivors

    International Nuclear Information System (INIS)

    Diseases found in 2,104 consequetive inpatients between April 1981 and March 1986 were statistically analyzed. The incidence of disease increased in the following order: diabetes mellitus > heart disease > cerebrovascular disorder > malignancy > hypertensive disease > arteriosclerosis > osteoarthritis. Malignancy is the most common cause of death or the highest mortality rate, followed by heart disease, cerebrovascular disorder, and liver cirrhosis. For the number of autopsy, the order of diseases was: malignancy, cardiovascular disease, gastrointestinal disease, respiratory tract disease, endocrine disease, and hematopoietic disease; for the incidence of autopsy, the order was: liver cirrhosis, diabetes mellitus, cerebrovascular disorder, malignancy, and heart disease. Malignancy accounted for 23 % of the inpatients. The incidence of malignancy increased in the following organs: stomach > liver > colon > lung > breast > biliary tract > esophagus. The incidence of leukemia was low. There was no definitive correlation between the incidence of malignancy and exposure distance, although the incidence of breast cancer tended to be high in the group exposed at ≤2,000 m from the hypocenter. According to age class, gastric cancer was frequent in patients less than 40 years and more than 60 years. Liver cancer was the most common in the sixtieth decade of life of men. The incidence of lung cancer increased with advancing age; the incidence of breast cancer was higher in younger patients. (Namekawa, K.)

  12. Statistical methods for site-specific analysis of cancer among the A-bomb survivors

    International Nuclear Information System (INIS)

    Statistical methods are presented for joint, or simultaneous, analysis of the risks of several types of cancer for the A-bomb survivors. Previous analyses have been made either for all cancers except leukemia together, or have been done separately by cancer type. Either of these approaches has serious limitations, and the aim of joint analysis is to overcome these, while taking advantage of the strengths of each. The primary advantage of joint analysis is that models for risks of various cancer types can have some parameters in common, and others which are type-specific. This serves to overcome difficulties due to the limited data on specific cancer types. It also provides for significant tests comparing both type-specific risks and type-specific effects of modifying factors such as sex and age. These methods are exemplified here by joint analysis of three classes of cancer considered by the BEIR-V committee: (i) respiratory, (ii) digestive, and (iii) other cancers, excluding leukemia and breast cancer. The primary aim is to illustrate the general advantages of joint analyses, but in addition some comparison is made between the results of such joint analyses and the conclusions drawn by BEIR-V committee from separate analyses. (author)

  13. Histological types of lung cancer in Japanese A-bomb survivors and Colorado plateau uranium miners

    International Nuclear Information System (INIS)

    In an investigation of possible differences between lung cancers induced by inhaled radon daughters and external gamma ray and neutrons, a blind pathology panel review was carried out of tissue slides from lung cancer cases diagnosed among 108 Japanese A-bomb survivors and 92 American uranium miners. Slides were selected on the basis of radiation exposure, smoking history, sex, age, and source and quality of pathology material. Consensus diagnoses were obtained with respect to principal subtype, including squamous cell cancer, small cell cancer, adenocarcinoma, and less frequent subtypes. The results were analyzed in terms of population, radiation dose, and smoking history. As expected, the proportion of squamous cell cancer was positively related to smoking history in both populations. The relative frequencies of small cell cancer and adenocarcinoma were very different in the two populations, but this difference was adequately accounted for by differences in radiation dose (more specifically, dose-based relative risk estimates based on published risk coefficients). Data for the two populations conformed to a common pattern, in which radiation-induced cancers appeared more likely to be of the small-cell subtype, and less likely to be adenocarcinomas. No additional explanation in terms of radiation quality (alpha particles vs. gamma rays), uniform or local irradiation, inhaled vs. external radiation source, or other population differences, appeared to be required. (author)

  14. Workshop report on atomic bomb dosimetry-residual radiation exposure: recent research and suggestions for future studies.

    Science.gov (United States)

    Kerr, George D; Egbert, Stephen D; Al-Nabulsi, Isaf; Beck, Harold L; Cullings, Harry M; Endo, Satoru; Hoshi, Masaharu; Imanaka, Tetsuji; Kaul, Dean C; Maruyama, Satoshi; Reeves, Glen I; Ruehm, Werner; Sakaguchi, Aya; Simon, Steven L; Spriggs, Gregory D; Stram, Daniel O; Tonda, Tetsuji; Weiss, Joseph F; Weitz, Ronald L; Young, Robert W

    2013-08-01

    There is a need for accurate dosimetry for studies of health effects in the Japanese atomic bomb survivors because of the important role that these studies play in worldwide radiation protection standards. International experts have developed dosimetry systems, such as the Dosimetry System 2002 (DS02), which assess the initial radiation exposure to gamma rays and neutrons but only briefly consider the possibility of some minimal contribution to the total body dose by residual radiation exposure. In recognition of the need for an up-to-date review of the topic of residual radiation exposure in Hiroshima and Nagasaki, recently reported studies were reviewed at a technical session at the 57th Annual Meeting of the Health Physics Society in Sacramento, California, 22-26 July 2012. A one-day workshop was also held to provide time for detailed discussion of these newer studies and to evaluate their potential use in clarifying the residual radiation exposures to the atomic-bomb survivors at Hiroshima and Nagasaki. Suggestions for possible future studies are also included in this workshop report. PMID:23799498

  15. Workshop Report on Atomic Bomb Dosimetry--Residual Radiation Exposure: Recent Research and Suggestions for Future Studies

    Energy Technology Data Exchange (ETDEWEB)

    None

    2013-06-06

    There is a need for accurate dosimetry for studies of health effects in the Japanese atomic bomb survivors because of the important role that these studies play in worldwide radiation protection standards. International experts have developed dosimetry systems, such as the Dosimetry System 2002 (DS02), which assess the initial radiation exposure to gamma rays and neutrons but only briefly consider the possibility of some minimal contribution to the total body dose by residual radiation exposure. In recognition of the need for an up-to-date review of the topic of residual radiation exposure in Hiroshima and Nagasaki, recently reported studies were reviewed at a technical session at the 57th Annual Meeting of the Health Physics Society in Sacramento, California, 22-26 July 2012. A one-day workshop was also held to provide time for detailed discussion of these newer studies and to evaluate their potential use in clarifying the residual radiation exposures to the atomic-bomb survivors at Hiroshima and Nagasaki. Suggestions for possible future studies are also included in this workshop report.

  16. Clinical study of infectious diseases on aged A-bomb survivors in Hiroshima Welfare Home for aged A-bomb survivors

    International Nuclear Information System (INIS)

    Infections, especially urinary passage and respiratory infections of aged A-bomb survivers under special protective care was examined. Urinary passage infections have recently shown an increasing tendency. These infections are related to the factors such as their basic diseases and wearing napkins rather than a severe degree of protective care. In the case of respiratory infection, diseases such as influenza are observed rather in patients who can walk, but they tend to be aggravated in bedridden patients. It cannot be said that more urinary passage infections are observed in A-bomb survivers than non A-bomb survivers. Both urinary passage infection and respiratory infection tend to recur repeatedly. Aged A-bomb survivers show no significant difference of acquired immunity from that of non A-bomb survivers group. However, a maintenance of neutralizing antibody by vaccination of influenza in the former is worse than in the latter. Bedridden patients show a higher rate of infection to potential urinary passage diseases than patients who can walk, irrespective of sex. Moreover, bedridden patients have a large number of bacteria, but other significant host reaction couldn't be observed. In bedridden patients with potential urinary passage infection, a variety of bacteria, most of which are bacteria resistant to rutinely used broad spectrum antibiotics, is detected. As a main disease or a direct cause of death, pyelonephritis in women and bronchopneumonia are often observed. (Iwagami, H.)

  17. Role of neutrons in late effects of radiation among A-Bomb survivors

    International Nuclear Information System (INIS)

    Experimental findings of many kinds as well as the Rossi-Kellerer theory of dual radiation action suggest that neutrons and gamma rays may differ in their biological effects, especially carcinogenesis, upon man. In particular, for many but not necessarily all cancers the carcinogenic effect of neutrons may be linear, and that of gamma- or X-radiation, a more complex function with linear and quadratic terms; in addition, dose-response functions for both types of radiation probably require a modifying factor to account for the frequently observed turn-down of dose-response curves in the high-dose region. In a further analysis of leukemia among A-Bomb survivors, Ishimaru et al. have fitted the function y a0 + a1n + a2γ2 where the a's are constants and n and γ the respective neutron and gamma doses. They find not only that this function fits the data well, although not significantly better than a straight line, but also that the best estimate of relative biological effectiveness (RBE) for neutrons is 44n-1/2. In the present paper we report our efforts to re-analyze ABCC-RERF data on a variety of late radiation effects in an effort to distinguish between neutron and gamma radiation more sharply than has been possible in the past. The effects examined include: chromosomal aberrations, small heads and mental retardation, leukemia, thyroid cancer, lung cancer, breast cancer, stomach cancer, esophageal cancer, lymphomas. The results of fitting various models will be reported. Goodness of fit will be examined and efforts will be made to derive RBE estimates. (author)

  18. Effects of IL-10 haplotype and atomic bomb radiation exposure on gastric cancer risk.

    Science.gov (United States)

    Hayashi, Tomonori; Ito, Reiko; Cologne, John; Maki, Mayumi; Morishita, Yukari; Nagamura, Hiroko; Sasaki, Keiko; Hayashi, Ikue; Imai, Kazue; Yoshida, Kengo; Kajimura, Junko; Kyoizumi, Seishi; Kusunoki, Yoichiro; Ohishi, Waka; Fujiwara, Saeko; Akahoshi, Masazumi; Nakachi, Kei

    2013-07-01

    Gastric cancer (GC) is one of the cancers that reveal increased risk of mortality and incidence in atomic bomb survivors. The incidence of gastric cancer in the Life Span Study cohort of the Radiation Effects Research Foundation (RERF) increased with radiation dose (gender-averaged excess relative risk per Gy = 0.28) and remains high more than 65 years after exposure. To assess a possible role of gene-environment interaction, we examined the dose response for gastric cancer incidence based on immunosuppression-related IL-10 genotype, in a cohort study with 200 cancer cases (93 intestinal, 96 diffuse and 11 other types) among 4,690 atomic bomb survivors participating in an immunological substudy. Using a single haplotype block composed of four haplotype-tagging SNPs (comprising the major haplotype allele IL-10-ATTA and the minor haplotype allele IL-10-GGCG, which are categorized by IL-10 polymorphisms at -819A>G and -592T>G, +1177T>C and +1589A>G), multiplicative and additive models for joint effects of radiation and this IL-10 haplotyping were examined. The IL-10 minor haplotype allele(s) was a risk factor for intestinal type gastric cancer but not for diffuse type gastric cancer. Radiation was not associated with intestinal type gastric cancer. In diffuse type gastric cancer, the haplotype-specific excess relative risk (ERR) for radiation was statistically significant only in the major homozygote category of IL-10 (ERR = 0.46/Gy, P = 0.037), whereas estimated ERR for radiation with the minor IL-10 homozygotes was close to 0 and nonsignificant. Thus, the minor IL-10 haplotype might act to reduce the radiation related risk of diffuse-type gastric cancer. The results suggest that this IL-10 haplotyping might be involved in development of radiation-associated gastric cancer of the diffuse type, and that IL-10 haplotypes may explain individual differences in the radiation-related risk of gastric cancer. PMID:23772925

  19. A search for genetic effects of atomic bomb radiation on the growth and development of the F1 generation, 2

    International Nuclear Information System (INIS)

    A comparative study to detect possible genetic effects of atomic bomb radiation on the growth and development of offspring of A-bomb survivors was made on a group of senior high school students 15 to 17 years of age born to survivors and to nonexposed parents in Hiroshima using as variables weight, sitting height, and chest circumference. Using data from students born to nonexposed parents, regression analysis was made to determine the effect of parental age on the weight, sitting height, and chest circumference of the offspring, but no statistically significant relation was observed. The mean and variance values of weight, sitting height, and chest circumference of offspring of nonexposed parents were compared to those of offspring born to exposed father and nonexposed mother, and of offspring born to exposed mother and nonexposed father, but very few statistically significant differences were found. The mean and variance values of weight, sitting height, and chest circumference of offspring born to nonexposed parents were compared to those of offspring born to parents both exposed, and again there were very few statistically significant differences. No specific tendency was observed in relation to the combined radiation dose of both parents. (author)

  20. Outline of developing projects of atomic bomb in Japan and USA

    International Nuclear Information System (INIS)

    The content of the title connecting with the World War II is described hoping that younger researchers of nuclear physics could know some of the facts that scientists and the military of Japan and USA, respectively, had have developing projects of atomic bomb by fission reaction, although there are no official documents of those in Japan, even if there are some unofficial documents that are uncertain partly in Japan. Described are a chronological table, the content of research and development of atomic bombs, Japan's experiments by Kikuchi Laboratory of Osaka Imperial University and Nishina Laboratory of RIKEN, as well as the USA's action such as production of fissile nuclide, Pu-239 and U-235, selection of the site to fabricate atomic bomb, investigation the state of research and development of atomic bombs in Germany, Italy and Japan. (S.Y.)

  1. Studies of radioactivity produced by the Hiroshima atomic bomb, 2

    International Nuclear Information System (INIS)

    Three studies of fallout measurements were reviewed for the discussion of possible radioactivity intake from the Hiroshima atomic bomb. The first study discussed correlations between enriched 234U and 137Cs specific activities from the measurement of soil samples collected in the 'black rain' area. The second study measured 137Cs activity on the rock and roof tile samples collected in the hypocenter area immediately after the explosion. Some of the rock and roof tile samples collected near the hypocenter had a small but detectable amount of 137Cs activity. However, it has been determined that 137Cs exposure, for example, was negligible compared with DS86 dose estimates, since these activity levels were low. The third study detected 90Sr activity in some of the specimens of human bones exhumed on Ninoshima Island. This study compared the difference in activity between the bone head and shaft, with higher activities obtained in the bone head. This fact suggests a short intake period for this activity, however, the levels of 90Sr contamination were too low to allow a discussion of the exposure risks. (author)

  2. Long-term effects of the rain exposure shortly after the atomic bombings in Hiroshima and Nagasaki.

    Science.gov (United States)

    Sakata, Ritsu; Grant, Eric J; Furukawa, Kyoji; Misumi, Munechika; Cullings, Harry; Ozasa, Kotaro; Shore, Roy E

    2014-12-01

    The "black rain" that fell after the atomic bombings of Hiroshima and Nagasaki has been generally believed to contain radioactive materials. During 1949-1961 the Atomic Bomb Casualty Commission conducted surveys that included a query about exposure to the rain that fell a short time after the bombings. This article presents the first report of those data in relation to possible adverse health outcomes. This study looked at Life Span Study subjects who were in either city at the time of bombing and had an estimated direct radiation dose from the bombs (n = 86,609). The mortality data from 1950-2005 and cancer incidence data from 1958-2005 were used. Excess relative risks (ERRs) of subjects who were exposed to rain compared to those who reported no rain exposure were calculated using a Poisson regression model. In Hiroshima 11,661 subjects (20%) reported that they were exposed to rain, while in Nagasaki only 733 subjects (2.6%) reported rain exposure. To avoid outcome dependent biases (i.e., recall of exposure after a health outcome has already occurred), the primary analyses were based on events that occurred during 1962-2005. No significant risks due to rain exposure were observed for death due to all causes, all solid cancer or leukemia in Hiroshima. In Nagasaki there was no significantly elevated rain exposure-associated risks for 1962-2005, however, for 1950-2005 there was a weak association for all-cause mortality (ERR = 0.08; 95% confidence interval 0.00006, 0.17; P = 0.05). For incidence of solid cancer and leukemia, no significantly elevated rain exposure risks were observed in either city. These results failed to show deleterious health effects from rain exposure. While these data represent the most extensive set of systematically collected data on rain exposure of the atomic bomb survivors, they are limited by substantial uncertainties regarding exposures and missing individual data, so cautious interpretation is advised. PMID:25402555

  3. Electron spin resonance analysis of tooth enamel does not indicate exposures to large radiation doses in a large proportion of distally-exposed A-bomb survivors.

    Science.gov (United States)

    Hirai, Yuko; Kodama, Yoshiaki; Cullings, Harry M; Miyazawa, Chuzo; Nakamura, Nori

    2011-01-01

    The atomic bombs in Hiroshima and Nagasaki led to two different types of radiation exposure; one was direct and brief and the other was indirect and persistent. The latter (so-called exposure to residual radiation) resulted from the presence of neutron activation products in the soil, or from fission products present in the fallout. Compared with the doses from direct exposures, estimations of individual doses from residual radiation have been much more complicated, and estimates vary widely among researchers. The present report bases its conclusions on radiation doses recorded in tooth enamel from survivors in Hiroshima. Those survivors were present at distances of about 3 km or greater from the hypocenter at the time of the explosion, and have DS02 estimated doses (direct exposure doses) of less than 5 mGy (and are regarded as control subjects). Individual doses were estimated by measuring CO(2)(-) radicals in tooth enamel with the electron spin resonance (ESR; or electron paramagnetic resonance, EPR) method. The results from 56 molars donated by 49 survivors provided estimated doses which vary from -200 mGy to 500 mGy, and the median dose was 17 mGy (25% and 75% quartiles are -54 mGy and 137 mGy, respectively) for the buccal parts and 13 mGy (25% and 75% quartiles: -49 mGy and 87 mGy, respectively) for the lingual parts of the molars. Three molars had ESR-estimated doses of 300 to 400 mGy for both the buccal and lingual parts, which indicates possible exposures to excess doses of penetrating radiation, although the origin of such radiation remains to be determined. The results did not support claims that a large fraction of distally-exposed survivors received large doses (e.g. 1 Gy) of external penetrating radiation resulting from residual radiation. PMID:21768749

  4. A search for effects of atomic bomb radiation on the growth and development of the F1 generation, 4

    International Nuclear Information System (INIS)

    A comparative study to detect possible genetic effects of atomic bomb radiation on the growth and development of offspring of A-bomb survivors was made on a group of junior high school students 12 to 14 years of age born to exposed and to nonexposed parents in Hiroshima using as variables weight, sitting height, and chest circumference. With data from offspring born to nonexposed parents, a regression analysis was made for the effect of parental age on the weight, sitting height, and chest circumference of the offspring, but no statistically significant relation was observed. The mean values of weight, sitting height, and chest circumference of offspring of nonexposed parents were compared with those of offspring born to exposed fathers and nonexposed mothers, of exposed mothers and nonexposed fathers, and with those of offspring of parents both exposed. The differences showed no specific tendency and very few of them were statistically significant. Next, the variance values were compared, and some of the differences between the two groups of offspring were statistically significant; in every case the variance of offspring of exposed parents was larger, suggesting a genetic effect due to exposure to A-bomb radiation. However, the sample of offspring born to exposed parents is small and the parent-offspring correlation is unknown for want of comparable measurements on the parents. (author)

  5. A search for genetic effects of atomic bomb radiation on the growth and development of the F1 generation, 3

    International Nuclear Information System (INIS)

    In a search for possible genetic effects of atomic bomb radiation on the stature of the offspring of A-bomb survivors a comparative study has been made of junior high school students 12 to 14 years of age born in Hiroshima to exposed and nonexposed parents. The mean stature and variance of the offspring and the covariance and correlation between one parent or the sum for both parents and their children were compared. The observed differences were both positive and negative in sign, and only a few were statistically significant. No clear tendency was demonstrated. When one parent was exposed, seven variance values of the offspring were statistically significant and six were positive in sign. Regression analyses of the mean stature and variance of the offspring, or the covariance, and correlation between one parent or the sum for both parents and their offspring by parental radiation dose revealed no clear effects of exposure. Only a very few of the regression coefficients were significantly different from zero. While genetic effects of A-bomb radiation on the stature of the children of exposed parents cannot be ruled out by this study, neither can such effects be unequivocally demonstrated. (author)

  6. Atomic bombs and the long-run effect on trust: Experiences in Hiroshima and Nagasaki.

    OpenAIRE

    YAMAMURA, Eiji

    2012-01-01

    Hiroshima and Nagasaki in Japan are the only cities in the world that have experienced an atomic bomb attack. This paper explores how this devastating experience affected victims’ tendency to trust others. Individual-level data were used to examine the long-term influence of experiencing an atomic bomb on individuals’ trust. After controlling for individual characteristics, I obtained the following key findings. Individuals who experienced the attack were more likely to trust others. Furtherm...

  7. Effects of the Atomic Bomb Explosion in Nagasaki : A Medical Perspective 1

    OpenAIRE

    Kishikawa, Masao; Mine, Mariko; Okumura, Yutaka

    1991-01-01

    A review of the medical effects of the Nagasaki atomic bomb explosion encountered between 1945 and 1990 was conducted. In the early stage, severe and various manifestations due to a combination of heat rays, blast and radiation were detected, but the accurate number of deaths among victims during this early period remains obscure. Keloid scars, cataract, leukemia, thyroid cancer, breast cancer and lung cancer have been established as diseases related to the atomic bomb explosion. Recent epide...

  8. The observed relationship between the occurrence of acute radiation sickness and subsequent cancer mortality among A-bomb survivors in Hiroshima and Nagasaki

    International Nuclear Information System (INIS)

    In an analysis of data obtained from the Life Span Study, a follow-up study of a fixed population of 73,330 atomic bomb survivors in Hiroshima and Nagasaki, the slope of a linear dose response between the estimated dose of ionizing radiation and leukemia mortality was found to be steeper (p 0.2) by the presence of epilation. The results for leukemia were not modified by age or sex and were consistent in both cities. These observations suggest that those individuals who experienced early effects of radiation were more likely to die of leukemia during the follow-up period than individuals who were exposed to the same level of A-bomb radiation but did not develop epilation. The robustness of this finding on the interaction of two difficult but important problems was investigated. These were the validity of a linear dose-response model for leukemia, and the level of assumed precision of the radiation dosimetry system used for assignment of dose estimates to individual survivors. Assuming 35 % random dose errors and a dose-response function cubic in dose, the excess relative risk for leukemia was still estimated to be 1.89 times higher for the group with epilation, and the p-value for a test of association between leukemia and epilation remained significant at the 0.10 level. If 50 % random dosimetry errors are assumed using the same cubic model, the dose response in the epilation group is estimated to be 1.58 times higher than the others, but is not significant (p < 0.3). (author)

  9. A search for genetic effects of atomic bomb radiation on the growth and development of the F1 generation, 1

    International Nuclear Information System (INIS)

    In a search for possible genetic effects of atomic bomb radiation on the growth and development of offspring of A-bomb survivors a survey was made in 1965 on approximately 200,000 children of all primary schools, junior high schools, and senior high schools in the cities of Hiroshima and Nagasaki. Of the collected data, those pertaining to senior high school students 15 to 17 years of age of Hiroshima City were analyzed to determine if there was any genetic effect of A-bomb radiation on stature. Comparisons were made with regard to the mean stature and variance of the offspring and the covariance and correlation between one parent or the sum for both parents and offspring for the exposed group and the nonexposed group. The observed differences included those with both positive and negative signs, but none were statistically significant nor did they demonstrate any specific tendency. A comparison was made with a similar study reported by Neel and Schull. Furthermore, estimation of the regression coefficients of the mean stature, variance, covariance, and correlation between one parent or the sum for both parents and offspring by parental radiation dose also did not show any specific tendency. Though the genetic effects of A-bomb radiation on stature could not be accurately estimated in the current series of analyses, the stature data of 6- to 14-year-old children in Hiroshima and those of 6- to 17-year-old children in Nagasaki Will soon be studied, which should permit a more comprehensive and extensive analysis and evaluation of the possible genetic effects of radiation on stature. (author)

  10. Statistical report of A-bomb survivors detailed health examinations October 197 - March 1976

    International Nuclear Information System (INIS)

    The subject was 82,705 persons, and the number of female was larger by about 16,000. The number of cases which were exposed to atomic bomb at places within 2.0 km far from the center of explosion was 476 (212 males and 264 females), and it was 10.2% of the total. With respect to a correlation of each item for general examinations estimated from the statistical values, the mean age of male was 52.9 years old, and correlations of age with the number of erythrocytes, blood sedimentation, and hemoglobin were high. The mean age of female was 53.3 years old, and a correlation of age with the maximum blood pressure was high, while correlations of age, with blood sedimentation, and hemoglobin were not so high. The number of leukocyte was directly proportional to urine sugar only in male. Correlation coefficients between urobilinogen and protein in urine were low in both female and male. A correlation between the maximum blood pressure and the minimum blood pressure was properly high, and the maximum blood pressure in both female and male was directly proportional to age. In female, both the maximum and minimum blood pressures were directly proportional to the number of erythrocytes and hemoglobin. There was the highest correlation between the distance from the center of explosion and the minimum blood pressure in female and male. Factor analysis made on the basis of the above-mentioned correlation matrix demonstrated that the first factor was erythrocyte, and the second factor was blood pressure. (Kanao, N.)

  11. Why didn't Hitler get the atomic bomb

    International Nuclear Information System (INIS)

    This bibliographical note presents a book in which the author reports his historical studies on the Nazi's nuclear activities as, by the end of the 1930's, Germany was probably the leader in this domain. He mentions and describes the various programs that were launched between 1939 and 1945, discusses some evidences related to the fact that the Germans probably tried to master nuclear energy production, and that they might have tested a weapon containing fissile materials (probably a dirty bomb). The author analyses the reasons of the failure of this nuclear sector: a lack of organization, war and bombings, and a relative lack of interest of political authorities

  12. Seeing the Light: Visibility of the July '45 Trinity Atomic Bomb Test from the Inner Solar System

    Science.gov (United States)

    Reed, B. Cameron

    2006-01-01

    In his "The Making of the Atomic Bomb," Richard Rhodes remarks of the July 16, 1945, Trinity atomic bomb test in New Mexico that "had astronomers been watching they could have seen it reflected from the moon, literal moonshine," an allusion to Ernest Rutherford's famous dismissal of the prospect of atomic energy. Investigating…

  13. Nuclear shadows on silvered walls: Atomic Bomb Cinema, from 1935 to 1991

    Energy Technology Data Exchange (ETDEWEB)

    Shapiro, J.F.

    1991-01-01

    The cinema and the atomic bomb are two of the most significant technological innovations of the past-century - their influence on culture has provoked tremendous political, academic, and popular debate. The point at which these two technologies intersect is what the author calls Atomic Bomb Cinema.' Since 1945 almost six hundred films with images of nuclear weapons have been released in the US, and they have been virtually ignored by everyone but the film going public. This study shows how Bomb films' use recurring themes and formal structures, and therefore must be treated as a coherent body of films; identifies historical, mythological, and contemporary motifs; and analyzes these films from two points of view: interdisciplinary (history, politics, economics, sociology, and aesthetics) and cross-cultural (American, Japanese, British, and Australian). The most important element of Atomic Bomb Cinema is the Apocalyptic Imagination; film makers use it to structure their narratives and explore a wide range of ideological issues. In contrast to commonly held beliefs, Atomic Bomb Cinema is undeniably part of a process that helps people to understand the threat of nuclear war. In this instance, the cinema is one cultural institution that contributes to a healthy society.

  14. Impact of the Boston Marathon Bombing and Its Aftermath on Refugees and Survivors of Torture.

    Science.gov (United States)

    Piwowarczyk, Linda; Rous, Dana; Mancuso, Anna; Flinton, Kathleen; Hastings, Erica; Forbush, Leigh; Shepherd, Amy

    2016-08-01

    On April 15, 2013, Boston residents and guests gathered for the Boston Marathon. Two explosives at the finish line killed three people and injured hundreds of others. As part of our clinical encounters, patients of the Boston Center for Refugee Health & Human Rights were asked about the marathon bombing. We were concerned about the high level of armed security as many of our patients had been detained in their countries of origin. Eighty patients seen between April 16 and July 7, 2013 were asked about their experience of the Boston Marathon bombing and its aftermath. A retrospective chart review was undertaken and data analyzed using Atlas.ti & SPSS. Approximately 86 % of those interviewed were reminded of their past trauma. The following themes emerged: triggering and trauma related symptoms, content specific cognitive schemas, recognition of the universality of violence, fears of discrimination, issues surrounding safety, and specific concerns of Muslims.

  15. Impact of the Boston Marathon Bombing and Its Aftermath on Refugees and Survivors of Torture.

    Science.gov (United States)

    Piwowarczyk, Linda; Rous, Dana; Mancuso, Anna; Flinton, Kathleen; Hastings, Erica; Forbush, Leigh; Shepherd, Amy

    2016-08-01

    On April 15, 2013, Boston residents and guests gathered for the Boston Marathon. Two explosives at the finish line killed three people and injured hundreds of others. As part of our clinical encounters, patients of the Boston Center for Refugee Health & Human Rights were asked about the marathon bombing. We were concerned about the high level of armed security as many of our patients had been detained in their countries of origin. Eighty patients seen between April 16 and July 7, 2013 were asked about their experience of the Boston Marathon bombing and its aftermath. A retrospective chart review was undertaken and data analyzed using Atlas.ti & SPSS. Approximately 86 % of those interviewed were reminded of their past trauma. The following themes emerged: triggering and trauma related symptoms, content specific cognitive schemas, recognition of the universality of violence, fears of discrimination, issues surrounding safety, and specific concerns of Muslims. PMID:26289501

  16. FROM THE HISTORY OF PHYSICS: The development of the first Soviet atomic bomb

    Science.gov (United States)

    Goncharov, German A.; Ryabev, Lev D.

    2001-01-01

    In the late 1930s and early 1940s, two remarkable physical phenomena — the fission of heavy nuclei and the chain fission reaction — were discovered, implying that a new powerful source of energy (nuclear fission energy) might become a practical possibility for mankind. At that time, however, the political situation in the world made the development of the atomic bomb the main objective of nuclear energy research in the countries involved. The first atomic bombs, notoriously used in the war against Japan, were produced by the United States of America only six and a half years after the discovery of fission. Four years later, the first Soviet atomic bomb was tested. This was a major step toward the establishment of nuclear parity which led to stability and global peace and thus greatly influenced the destiny of human kind. Based on documentary materials covering the period from 1939 to 1949, this paper traces the origin and evolution of the physical ideas behind the first Soviet atomic bomb and discusses the most important events associated with the project.

  17. Harry Truman and the Atomic Bomb: An Excursion into Character Education through Storytelling

    Science.gov (United States)

    Sanchez, Tony R.

    2006-01-01

    This article asserts the importance of character education through the utilization of historical storytelling in the social studies classroom. After briefly noting the value of the historical story in this regard, a specific, ready-made example is provided concerning Truman's decision to use the atomic bomb and includes a crucial set of follow-up…

  18. Atomic bombing and nuclear energy development in Japan

    International Nuclear Information System (INIS)

    The victims of Hiroshima and Nagasaki introduced Japan to nuclear power. Approximately ten years after the bombing, the Japanese Parliament adopted a ''Nuclear Basic Law'', and unanimously proclaimed independence, democracy, and openness as indispensable prerequisites for the continued peaceful utilization of nuclear power. For more than a decade, the political party in government and the opposition parties unanimously adopted all legislation and ordinances connected with nuclear power as well as the necessary budgets. This led to the establishment of research and development institutions. The basic consensus underlying nuclear development in Japan has been the exclusion of any military use. The Japanese public perceives that a military component is not feasible in the country's development of nuclear power. (orig./UA)

  19. A comparison between the risks of childhood leukaemia from parental exposure to radiation in the Sellafield workforce and those displayed among the Japanese bomb survivors

    International Nuclear Information System (INIS)

    The cases of childhood leukaemia found near the Sellafield plant and those observed in the offspring of the Japanese bomb survivors are analysed using a relative risk model. The leukaemia relative risk coefficients for total paternal (whole-body) pre-conception exposure for the Sellafield children are found to be about 50 to 80 times higher than the (gonadal) coefficients applying to the offspring of the bomb survivors. This difference is statistically significant, and in particular the risk coefficients for the Sellafield cohort are significantly positive, unlike those for the Japanese. If the assumption is made that the excess relative risk estimated from the Sellafield data lasts for the whole of the life of the offspring, the apparent population leukaemia risk to the first-generation offspring (for an England and Wales population) would be between 4% Sv-1 and 5% Sv-1. (author)

  20. No evidence of increased mutation rates at microsatellite loci in offspring of A-bomb survivors.

    Science.gov (United States)

    Kodaira, M; Ryo, H; Kamada, N; Furukawa, K; Takahashi, N; Nakajima, H; Nomura, T; Nakamura, N

    2010-02-01

    To evaluate the genetic effects of A-bomb radiation, we examined mutations at 40 microsatellite loci in exposed families (father-mother-offspring, mostly uni-parental exposures), which consisted of 66 offspring having a mean paternal dose of 1.87 Gy and a mean maternal dose of 1.27 Gy. The control families consisted of 63 offspring whose parents either were exposed to low doses of radiation (Hiroshima or Nagasaki at the time of the bombs. We found seven mutations in the exposed alleles (7/2,789; mutation rate 0.25 x 10(-2)/locus/generation) and 26 in the unexposed alleles (26/7,465; 0.35 x 10(-2)/locus/generation), which does not indicate an effect from parental exposure to radiation. Although we could not assign the parental origins of four mutations, the conclusion may hold since even if we assume that these four mutations had occurred in the exposed alleles, the estimated mean mutation rate would be 0.39 x 10(-2) in the exposed group [(7 + 4)/2,789)], which is slightly higher than 0.35 x 10(-2) in the control group, but the difference is not statistically significant. PMID:20095853

  1. The Office of Censorship's Attempt to Control Press Coverage of the Atomic Bomb during World War II.

    Science.gov (United States)

    Washburn, Patrick S.

    The Office of Censorship's struggle to keep journalists from revealing the development of the first atomic bomb, the sites where the development was taking place, and the fact that the bomb might be available for use in the war, was desperate and in many ways heroic. Soon after it was created on December 19, 1941, the office issued a voluntary…

  2. Workshop Report on Atomic Bomb Dosimetry--Review of Dose Related Factors for the Evaluation of Exposures to Residual Radiation at Hiroshima and Nagasaki.

    Science.gov (United States)

    Kerr, George D; Egbert, Stephen D; Al-Nabulsi, Isaf; Bailiff, Ian K; Beck, Harold L; Belukha, Irina G; Cockayne, John E; Cullings, Harry M; Eckerman, Keith F; Granovskaya, Evgeniya; Grant, Eric J; Hoshi, Masaharu; Kaul, Dean C; Kryuchkov, Victor; Mannis, Daniel; Ohtaki, Megu; Otani, Keiko; Shinkarev, Sergey; Simon, Steven L; Spriggs, Gregory D; Stepanenko, Valeriy F; Stricklin, Daniela; Weiss, Joseph F; Weitz, Ronald L; Woda, Clemens; Worthington, Patricia R; Yamamoto, Keiko; Young, Robert W

    2015-12-01

    Groups of Japanese and American scientists, supported by international collaborators, have worked for many years to ensure the accuracy of the radiation dosimetry used in studies of health effects in the Japanese atomic bomb survivors. Reliable dosimetric models and systems are especially critical to epidemiologic studies of this population because of their importance in the development of worldwide radiation protection standards. While dosimetry systems, such as Dosimetry System 1986 (DS86) and Dosimetry System 2002 (DS02), have improved, the research groups that developed them were unable to propose or confirm an additional contribution by residual radiation to the survivor's total body dose. In recognition of the need for an up-to-date review of residual radiation exposures in Hiroshima and Nagasaki, a half-day technical session was held for reports on newer studies at the 59 th Annual HPS Meeting in 2014 in Baltimore, MD. A day-and-a-half workshop was also held to provide time for detailed discussion of the newer studies and to evaluate their potential use in clarifying the residual radiation exposure to atomic bomb survivors at Hiroshima and Nagasaki. The process also involved a re-examination of very early surveys of radioisotope emissions from ground surfaces at Hiroshima and Nagasaki and early reports of health effects. New insights were reported on the potential contribution to residual radiation from neutron-activated radionuclides in the airburst's dust stem and pedestal and in unlofted soil, as well as from fission products and weapon debris from the nuclear cloud. However, disparate views remain concerning the actual residual radiation doses received by the atomic bomb survivors at different distances from the hypocenter. The workshop discussion indicated that measurements made using thermal luminescence and optically stimulated luminescence, like earlier measurements, especially in very thin layers of the samples, could be expanded to detect possible

  3. Workshop Report on Atomic Bomb Dosimetry--Review of Dose Related Factors for the Evaluation of Exposures to Residual Radiation at Hiroshima and Nagasaki.

    Science.gov (United States)

    Kerr, George D; Egbert, Stephen D; Al-Nabulsi, Isaf; Bailiff, Ian K; Beck, Harold L; Belukha, Irina G; Cockayne, John E; Cullings, Harry M; Eckerman, Keith F; Granovskaya, Evgeniya; Grant, Eric J; Hoshi, Masaharu; Kaul, Dean C; Kryuchkov, Victor; Mannis, Daniel; Ohtaki, Megu; Otani, Keiko; Shinkarev, Sergey; Simon, Steven L; Spriggs, Gregory D; Stepanenko, Valeriy F; Stricklin, Daniela; Weiss, Joseph F; Weitz, Ronald L; Woda, Clemens; Worthington, Patricia R; Yamamoto, Keiko; Young, Robert W

    2015-12-01

    Groups of Japanese and American scientists, supported by international collaborators, have worked for many years to ensure the accuracy of the radiation dosimetry used in studies of health effects in the Japanese atomic bomb survivors. Reliable dosimetric models and systems are especially critical to epidemiologic studies of this population because of their importance in the development of worldwide radiation protection standards. While dosimetry systems, such as Dosimetry System 1986 (DS86) and Dosimetry System 2002 (DS02), have improved, the research groups that developed them were unable to propose or confirm an additional contribution by residual radiation to the survivor's total body dose. In recognition of the need for an up-to-date review of residual radiation exposures in Hiroshima and Nagasaki, a half-day technical session was held for reports on newer studies at the 59 th Annual HPS Meeting in 2014 in Baltimore, MD. A day-and-a-half workshop was also held to provide time for detailed discussion of the newer studies and to evaluate their potential use in clarifying the residual radiation exposure to atomic bomb survivors at Hiroshima and Nagasaki. The process also involved a re-examination of very early surveys of radioisotope emissions from ground surfaces at Hiroshima and Nagasaki and early reports of health effects. New insights were reported on the potential contribution to residual radiation from neutron-activated radionuclides in the airburst's dust stem and pedestal and in unlofted soil, as well as from fission products and weapon debris from the nuclear cloud. However, disparate views remain concerning the actual residual radiation doses received by the atomic bomb survivors at different distances from the hypocenter. The workshop discussion indicated that measurements made using thermal luminescence and optically stimulated luminescence, like earlier measurements, especially in very thin layers of the samples, could be expanded to detect possible

  4. Neutron and gamma ray calculation for Hiroshima-type atomic bomb

    Energy Technology Data Exchange (ETDEWEB)

    Hoshi, Masaharu; Endo, Satoru; Takada, Jun [Hiroshima Univ. (Japan). Research Inst. for Radiation Biology and Medicine; Iwatani, Kazuo; Oka, Takamitsu; Shizuma, Kiyoshi; Fujita, Shoichiro; Hasai, Hiromi

    1998-03-01

    We looked at the radiation dose of Hiroshima and Nagasaki atomic bomb again in 1986. We gave it the name of ``Dosimetry System 1986`` (DS86). We and other groups have measured the expose dose since 1986. Now, the difference between data of {sup 152}Eu and the calculation result on the basis of DS86 was found. To investigate the reason, we carried out the calculations of neutron transport and neutron absorption gamma ray for Hiroshima atomic bomb by MCNP3A and MCNP4A code. The problems caused by fast neutron {sup 32}P from sulfur in insulator of pole. To correct the difference, we investigated many models and found agreement of all data within 1 km. (S.Y.)

  5. A Method to Estimate the Fast-Neutron Fluence for the Hiroshima Atomic Bomb

    Science.gov (United States)

    Shibata, Tokushi; Imamura, Mineo; Shibata, Seiichi; Uwamino, Yoshitomo; Ohkubo, Tohru; Satoh, Shinngo; Nogawa, Norio; Hasai, Hiromi; Shizuma, Kiyoshi; Iwatani, Kazuo; Hoshi, Masaharu; Oka, Takamitsu

    1994-10-01

    A new method to estimate the fast-neutron fluence of the Hiroshima atomic bomb is proposed. 63Ni produced by the 63Cu(n, p)63Ni reaction provides a unique measure by which to estimate the fast-neutron fluence of the Hiroshima/Nagasaki atomic bombs, because the half-life of 63Ni is 100 years and 70% of the 63Ni produced in a copper piece presently exists after 50 years. Using the neutron spectrum given in DS86 and the estimated cross section, we found that a piece of copper of about 10 g which was exposed at a point around 100 m from the hypocenter gives a measurable amount of 63Ni using a low-background liquid scintillation counter. For the measurement of 63Ni, accelerator mass spectrometry also seems to be applicable.

  6. Effect of aging on the competence for physical defence among A-bomb survivors, 4

    International Nuclear Information System (INIS)

    In A-bomb exposed and non-exposed groups of patients with myelodysplastic syndrome (MDS), including refractory anemia (RA), T and B lymphocyte subsets and stem cell colony formation were analyzed using flow cytometry. There was no significant difference in the number of T lymphocyte subsets between the exposed and non-exposed RA groups. The number of cells positive for B-1 (CD20) was, however, significantly lower in exposed RA patients than normal volunteers (p < 0.01). In some of the exposed and non-exposed RA patients, the number of supressor inducer subsets were increased. For the other MDS types, more patients developed leukemia in the non-exposed group than those in the exposed group. CFU-E colony formation was observed in the absence of erythropoietin in the total incidence of 37 % (7/19) in both exposed and non-exposed groups, half of whom developed leukemia. For MDS patients in either the exposed or non-exposed group, there was no correlation between both T and B lymphocyte subsets and stem cell colony formation. (Namekawa, K.)

  7. Statistical analysis of the main diseases among atomic bomb survivors. Study of inpatients in Hiroshima Atomic Bomb Hospital, 1981 - 1986

    Energy Technology Data Exchange (ETDEWEB)

    Hamada, Tadao; Kuramoto, Kiyoshi; Nambu, Shigeru

    1988-03-01

    Diseases found in 2,104 consequetive inpatients between April 1981 and March 1986 were statistically analyzed. The incidence of disease increased in the following order: diabetes mellitus > heart disease > cerebrovascular disorder > malignancy > hypertensive disease > arteriosclerosis > osteoarthritis. Malignancy is the most common cause of death or the highest mortality rate, followed by heart disease, cerebrovascular disorder, and liver cirrhosis. For the number of autopsy, the order of diseases was: malignancy, cardiovascular disease, gastrointestinal disease, respiratory tract disease, endocrine disease, and hematopoietic disease; for the incidence of autopsy, the order was: liver cirrhosis, diabetes mellitus, cerebrovascular disorder, malignancy, and heart disease. Malignancy accounted for 23 % of the inpatients. The incidence of malignancy increased in the following organs: stomach > liver > colon > lung > breast > biliary tract > esophagus. The incidence of leukemia was low. There was no definitive correlation between the incidence of malignancy and exposure distance, although the incidence of breast cancer tended to be high in the group exposed at less than or equal to2,000 m from the hypocenter. According to age class, gastric cancer was frequent in patients less than 40 years and more than 60 years. Liver cancer was the most common in the sixtieth decade of life of men. The incidence of lung cancer increased with advancing age; the incidence of breast cancer was higher in younger patients. (Namekawa, K.).

  8. After Crossroads: The Fate of the Atomic Bomb Target Fleet

    Science.gov (United States)

    Delgado, James P.

    2016-04-01

    The atomic tests at Bikini Atoll left a submerged archaeological legacy in the form of sixty-one shipwrecks at or near Bikini, Kwajalein, the California coast, and in two other lesser cases off Oahu and the coast of Washington State. Together they comprise a unique maritime cultural landscape of the Cold War, and the naval aspects of that conflict.

  9. From the Dawn of Nuclear Physics to the First Atomic Bombs

    Science.gov (United States)

    Woolbright, Stephen; Schumacher, Jacob; Michonova-Alexova, Ekaterina

    2014-03-01

    This work gives a fresh look at the major discoveries leading to nuclear fission within the historical perspective. The focus is on the main contributors to the discoveries in nuclear physics, leading to the idea of fission and its application to the creation of the atomic bombs used at the end of the World War II. The present work is a more complete review on the history of the nuclear physics discoveries and their application to the atomic bomb. In addition to the traditional approach to the topic, focusing mainly on the fundamental physics discoveries in Europe and on the Manhattan Project in the United States, the nuclear research in Japan is also emphasized. Along with that, a review of the existing credible scholar publications, providing evidence for possible atomic bomb research in Japan, is provided. Proper credit is given to the women physicists, whose contributions had not always been recognized. Considering the historical and political situation at the time of the scientific discoveries, thought-provoking questions about decision-making, morality, and responsibility are also addressed. The work refers to the contributions of over 20 Nobel Prize winners. EM-A is grateful to Prof. Walter Grunden and to Prof. Emeritus Shadahiko Kano, Prof. Emeritus Monitori Hoshi for sharing their own notes, documents, and references, and to CCCU for sponsoring her participation in the 2013 Nuclear Weapons Seminar in Japan.

  10. Historical trend of ^<137>Cs released from Nagasaki atomic bomb recorded in sediment core of Nishiyama reservoir at Nagasaki, Japan

    OpenAIRE

    Yamazaki, Hideo; Yamamoto, Shizuka; Nishida, Hironori; Bessho, Keisuke; Kawashima, Asami; Kobashi, Kazuhiro

    2010-01-01

    In the dated core sediment of Nishiyama reservoir at Nagasaki city, historical distribution of ^Cs activity was determined. Sediment containing ^Cs, which was deposited immediately after a detonation of Nagasaki atomic bomb, was identified in the core. Observed in the sediments were macroscopic charcoals, ^Pu activity and ^Pu/^Pu isotopic ratio, and providing evidence for initial deposit of the fallout of the Nagasaki atomic bomb. This is the first entire depositional record of ^Cs released f...

  11. The children of parents exposed to atomic bombs: Estimates of the genetic doubling dose of radiation for humans

    International Nuclear Information System (INIS)

    The data collected in Hiroshima and Nagasaki during the past 40 years on the children of survivors of the atomic bombings and on the children of a suitable control population are analyzed on the basis of the newly revised estimates of radiation doses. No statistically significant effects emerge with respect to eight different indicators. Since, however, it may confidently be assumed some mutations were induced, we have taken the data at face value and calculated the minimal gametic doubling doses of acute radiation for the individual indicators at various probability levels. An effort has also been made to calculate the most probable doubling dose for the indicators combined. The latter value is between 1.7 and 2.2 Sv. It is suggested the appropriate figure for chronic radiation would be between 3.4 and 4.5 Sv. These estimates suggest humans are less sensitive to the genetic effects of radiation than has been assumed on the basis of past extrapolations from experiments with mice

  12. The children of parents exposed to atomic bombs: estimates of the genetic doubling dose of radiation for humans.

    Science.gov (United States)

    Neel, J V; Schull, W J; Awa, A A; Satoh, C; Kato, H; Otake, M; Yoshimoto, Y

    1990-06-01

    The data collected in Hiroshima and Nagasaki during the past 40 years on the children of survivors of the atomic bombings and on the children of a suitable control population are analyzed on the basis of the newly revised estimates of radiation doses. No statistically significant effects emerge with respect to eight different indicators. Since, however, it may confidently be assumed some mutations were induced, we have taken the data at face value and calculated the minimal gametic doubling doses of acute radiation for the individual indicators at various probability levels. An effort has also been made to calculate the most probable doubling dose for the indicators combined. The latter value is between 1.7 and 2.2 Sv. It is suggested the appropriate figure for chronic radiation would be between 3.4 and 4.5 Sv. These estimates suggest humans are less sensitive to the genetic effects of radiation than has been assumed on the basis of past extrapolations from experiments with mice. PMID:2339701

  13. The quantum exodus jewish fugitives, the atomic bomb, and the holocaust

    CERN Document Server

    Fraser, Gordon Murray

    2012-01-01

    It was no accident that the Holocaust and the Atomic Bomb happened at the same time. When the Nazis came into power in 1933, their initial objective was not to get rid of Jews. Rather, their aim was to refine German culture: Jewish professors and teachers at fine universities were sacked. Atomic science had attracted a lot of Jewish talent, and as Albert Einstein and other quantum exiles scattered, they realized that they held the key to a weapon of unimaginable power. Convincedthat their gentile counterparts in Germany had come to the same conclusion, and having witnessed what the Nazis were

  14. Late effects of atomic bomb radiation on human immune response, (9)

    International Nuclear Information System (INIS)

    In an attempt to determine the effects of A-bombing on EB virus activity and the involvement of cellular immunity, an experimental line was established in which cytotoxic lymphocytes against EB virus-infected autologous B cells are measured. Precursor frequency (PF) of cytotoxic lymphocytes against EB virus-infected autologous B cells, obtained from 3 healthy persons, was 0.21-3.1x10-3, providing relatively favorable reproducibility. Cytotoxic lymphocytes were scarcely detected in either umbilical blood cells or adult lymphocytes stimulated with peripheral blood mononuclear cells (PBMC), depending upon EB virus antigens. The PF of Leu 2a positive cells and Leu 3a positive cells, isolated from one normal volunteer, was 6.12x10-3 and 1.22x10-3, respectively. The PF of Leu 11c positive cells was low (0.39x10-3); however, it was high (3.76x10-3) in the presence of autologous PBMC irradiated with X-rays. This suggests that there is an interaction between CD16 and other cell groups. T-cells positive to Leu 3a and Leu 2a were specifically cytotoxic to lymphoblastoid cell line (LCL). T-cells positive to Leu 11c was nonspecific to antigens. These findings suggested that the experimental line in this series may be useful for evaluating cellular immunity capacity for EV virus. In a survey for 27 A-bomb survivors, A-bombing was found to have no influence on EB virus activity. (N.K.)

  15. Malignant tumors in people exposed as children to atomic bomb in Nagasaki

    International Nuclear Information System (INIS)

    In order to determine both the conditions under which malignant tumors occurred and the pathological specificity of those tumors in people exposed as children (at the age of 0-9) to the atomic bomb in Nagasaki, a comparative study was made of malignant tumors (including brain tumor but excluding leukemia) in 88 exposed cases taken from the data of the committee for the statistical analysis of tumors in Nagasaki and from other literature, and in unexposed cases of malignancy. The following items were analyzed; the distance from the bombed area (doses), the age at the time that the disease occurred, the latent period, the annual incidence of disease, the site of tumor, and the type of tissue. The results are summarized as follows, although they are inconclusive because of the small number of cases. The incidence of malignant lymphoma, cancer of the tyroid gland, brain tumor, sarcoma, and cancer of the ovary had a tendency to be higher in the exposed cases than in the unexposed cases. From the standpoint of sex, there was a tendency that cancer of the stomach and malignant lymphoma occurred more often in females than in males. On the other hand, sarcoma and brain tumor were seen more often in males. From the standpoint of the relationships among these factors: the distance from the bombed area, the latent period, and the type of tumor, it was suggested that cancer of the thyroid gland, brain tumor and cancer of the stomach were observed especially in cases which had been exposed as children. In addition, it was considered that the influence of not only a short distance from the bombed area but also a middle distance from that area can not be neglected. (Namekawa, K.)

  16. Reclassification of leukemia among A-bomb survivors in Nagasaki using French-American-British (FAB) classification for acute leukemia

    International Nuclear Information System (INIS)

    The concordance rate for diagnoses of atomic bomb-related cases of leukemia in Nagasaki was determined using the French-American-British (FAB) classification for acute leukemias and myelodysplastic syndromes (MDS). Two Radiation Effects Research Foundation (RERF) hematologists and one of the members (JMB) of the FAB cooperative group reviewed independently the peripheral blood and/or bone marrow smears from 193 people with leukemia or a related disorder. There was 85 % agreement in the identification of types and subtypes of acute leukemia. There was almost complete agreement for the diagnoses of non-FAB disorders (chronic myeloid leukemia (CML), adult T-cell leukemia (ATL) and others) resulting in overall concordance of 88.2 %. The present study suggest that the previously established leukemia types for about a quarter of the cases of acute leukemia and related disorders except CML should be changed. Considerable numbers of cases of ATL and MDS were involved in this series. The frequency of the former disease was not high in the high-dose irradiated group, but that of the latter was considerably high. All subtypes of AML except M3 and M6 were present in the high-dose group. The striking difference in CML incidence between Nagasaki and Hiroshima may continue to be a problem in relation to biological response to radiation exposure. (author)

  17. Did the Allies Know in 1942 About Nazi Germany's Poor Prospects for an Atomic Bomb?

    Science.gov (United States)

    Lustig, Harry

    2008-04-01

    According to official accounts, the U.S. knew nothing about Nazi Germany's efforts to get an atomic bomb until the end of the World War II, but had feared the worst. As it turned out, the Germans had made little progress. But did someone in the Allied camp know in 1942? In his 1986 book, The Griffin, Arnold Kramish relates how Paul Rosbaud, a spy for MI6, the British secret intelligence service, kept his handlers informed during the War about the German atomic project and reported the decision to give up on a bomb. Kramish's revelations are, understandably, thinly documented and Rosbaud's name can hardly be found independenly anywhere else. But as Samuel Goudsmit's papers in the Bohr Library show, he knew and communicated with Rosbaud from August 1945 on. In 1986, 15 letters exchanged by Goudsmit and Rosbaud were removed by the Government from the Library and eventually placed in the National Archives under classification review. Renewed interest in the Rosbaud story was engendered last year when his family sued MI6 in an English court for the release of the Rosbaud file. So far the spy agency has refused to reveal even that there is such a file. Discovering authoritatively what Rosbaud told the British and what they did with the information is clearly of historical interest.

  18. Medical x-ray exposure doses as contaminants of atomic bomb doses.

    Science.gov (United States)

    Yamamoto, O; Antoku, S; Russell, W J; Fujita, S; Sawada, S

    1988-03-01

    Since 1967 at the times of their biennial ABCC/RERF radiological examinations, all Adult Health Study (AHS) subjects have been interviewed to determine the exposures to medical x-rays they experienced in institutions other than RERF in order to estimate the numbers of examinations and corresponding doses which they received. These data have been stored on computer tapes together with the doses these subjects received during their radiological examinations in the ABCC/RERF Department of Radiology. Thus, their medical x-ray doses are available along with their atomic bomb doses (tentative 1965 doses revised, T65DR) for assessment of the role of ionizing radiation in the development of diseases. The medical x-ray doses incurred at RERF were assessed by means of phantom dosimetry. Those at other institutions were determined using phantom dosimetry data and results of surveys for trends in radiological examinations in Hiroshima and Nagasaki. By the end of 1982, the average medical x-ray doses to the active bone marrow were 12.04 mGy for A-bomb exposed groups and 8.92 mGy for control groups (not-in-cities); to the male gonads, 2.26 mGy and 1.89 mGy, respectively; and to the female gonads, 17.45 mGy and 12.58 mGy, respectively. Results for Hiroshima and Nagasaki were similar. The main impact of medical x-ray doses was in the lowest T65DR group. Medical x-ray active bone marrow doses ranged from 0.05-500% (mean, 35%) of A-bomb doses in the 10-99 mGy T65DR group. In the 100-999 mGy T65DR group, medical x-ray active bone marrow doses ranged from 0.005-50% (mean, 5%) of their T65DR. In the greater than 1,000-mGy T65DR group, medical x-ray exposures were proportionally less. Female active bone marrow and gonad doses were similar in magnitude to the male active bone marrow doses. Medical x-ray exposures produced smaller doses to the gonads of males than to those of the females. The use of medical x-rays is steadily increasing. Careful consideration of doses from medical sources

  19. Natural History of Disease in Atomic Bomb Exposed Twins in Hiroshima : Findings of Chest X-Ray and Electrocardiogram

    OpenAIRE

    Satow, Yukio; Ohmae, Kiyokazu; Okamoto, Naomasa; Abe, Tsutomu; Watanabe, Shoji

    1982-01-01

    The subjects of this study are mainly pairs of monozygotic twins, one of whom was exposed to the atomic bomb and the other not exposed, and the natural history of the diseases of these twins was analyzed to find out genetic and environmental factors of the diseases and some biological effect of the atomic bomb exposure or other. In this study, 13 pairs of monozygotic and 5 pairs of dizygotic twins and other 34 cases of non-twins were examined by means of heart and lung X-ray films and electro...

  20. An analysis of leukaemia, lymphoma and other malignancies together with certain categories of non-cancer mortality in the first generation offspring (F1) of the Japanese bomb survivors

    International Nuclear Information System (INIS)

    The absence of any significant excess of childhood leukaemia in the offspring of the Japanese bomb survivors has provided strong evidence against a causal interpretation of the association between paternal preconception radiation dose and the incidence of childhood leukaemia in the offspring of employees at the Sellafield nuclear installation, West Cumbria. The use of the Japanese data has, however, been questioned on the basis that leukaemia cases may have been under-recorded in the years immediately following the bombings. In order to investigate possible misdiagnoses of leukaemia cases in the first generation offspring (F1) of the Japanese bomb survivors, analyses have been undertaken of cases of leukaemia, non-Hodgkin's lymphoma (NHL), and all other malignancies, together with deaths due to blood diseases, deaths due to infectious diseases and deaths from unknown causes. (author)

  1. "A Is for Atom, B Is for Bomb": Civil Defense in American Public Education, 1948-1963.

    Science.gov (United States)

    Brown, JoAnne

    1988-01-01

    Discusses the development of civil defense education following World War II. Examines its effects on the public as atomic bomb drills became commonplace in schools which also served as fallout shelters. Concludes that inadequate portrayal of the horrors of nuclear war produced anger, fear, and disillusionment as the postwar generation matured.…

  2. Ending the War against Japan: Science, Morality, and the Atomic Bomb. Choices for the 21st Century.

    Science.gov (United States)

    Bakker, Don

    This unit presents students with dilemmas faced by U.S. policymakers with three distinct options for U.S. policy toward Japan. Background readings provide students with information on the U.S. decision to drop the atomic bomb on Japan in 1945. By exploring a spectrum of alternatives, students gain a deeper understanding of the values underlying…

  3. Echoing with the Voices of Victims: Reflection on Vietnamese Lessons on the Japanese Experiences of Atomic Bombs

    Science.gov (United States)

    Saito, Eisuke; Hien, Do Thi; Hang, Khong Thi Diem

    2010-01-01

    This article explores the case of a Vietnamese teacher whose conception of teaching changed greatly following a short but intensive series of lessons based on the Japanese experiences with atomic bombs. The following three issues are considered: 1) what types of efforts teachers should make to increase the depth of their lessons, on the basis of…

  4. Neuropsychiatric and psychologic effects of A-bomb radiation

    International Nuclear Information System (INIS)

    Few studies have assessed the influences of A-bombing from both psychiatric and psychologic points of view. This chapter deals with the knowledge of neuropsychiatric and psychologic influences of A-bombing. Many A-bomb survivors were exposed not only to radiation but also to rapid environmental alterations, such as death of family members and destruction of living. In addition, they suffered from sequelae and anxiety. Naturally, these were considered to cause psychological disturbance including autonomic imbalance and neurosis. Psychological survey, made immediately after A-bombing, is presented, with special attention to behavioral patterns in 54 A-bomb survivors by dividing them into 5 stimulation groups. Radiation syndrome occurring early after exposure and leukemia or cancer occurring later were referred to as 'Genbaku-sho' (A-bomb disease). A-bomb survivors' physically eventful conditions tended to induce mental anxiety or the contrary. Depression and phobia seemed to have correlated with physical conditions. In addition to 'A-bomb disease', mass media, dealing with 'A-bomb neurosis,' 'marriage in A-bomb survivors,' 'suicide in A-bomb survivors,' 'A-bomb survivors orphan,' and 'lonely old A-bomb survivors,' had a great impact on A-bomb survivors. For in uterus exposed and infantile A-bomb survivors, there was no significant difference between the exposed and non-exposed groups, although the incidence of eye tremor and sleeping disorder is found to be higher in the in uterus exposed group than the control group. (N.K.)

  5. Current risk estimates based on the A-bomb survivors data - a discussion in terms of the ICRP recommendations on the neutron weighting factor.

    Science.gov (United States)

    Rühm, W; Walsh, L

    2007-01-01

    Currently, most analyses of the A-bomb survivors' solid tumour and leukaemia data are based on a constant neutron relative biological effectiveness (RBE) value of 10 that is applied to all survivors, independent of their distance to the hypocentre at the time of bombing. The results of these analyses are then used as a major basis for current risk estimates suggested by the International Commission on Radiological Protection (ICRP) for use in international safety guidelines. It is shown here that (i) a constant value of 10 is not consistent with weighting factors recommended by the ICRP for neutrons and (ii) it does not account for the hardening of the neutron spectra in Hiroshima and Nagasaki, which takes place with increasing distance from the hypocentres. The purpose of this paper is to present new RBE values for the neutrons, calculated as a function of distance from the hypocentres for both cities that are consistent with the ICRP60 neutron weighting factor. If based on neutron spectra from the DS86 dosimetry system, these calculations suggest values of about 31 at 1000 m and 23 at 2000 m ground range in Hiroshima, while the corresponding values for Nagasaki are 24 and 22. If the neutron weighting factor that is consistent with ICRP92 is used, the corresponding values are about 23 and 21 for Hiroshima and 21 and 20 for Nagasaki, respectively. It is concluded that the current risk estimates will be subject to some changes in view of the changed RBE values. This conclusion does not change significantly if the new doses from the Dosimetry System DS02 are used. PMID:17533156

  6. Britain's bomb

    Science.gov (United States)

    Corfield, Richard

    2012-10-01

    On the 60th anniversary of Britain's first nuclear test, Richard Corfield explores how Operation Hurricane - the British effort to develop the atomic bomb in the 1940s and 1950s - compares with states such as Iran that today wish to have such devices.

  7. 原子钟、原子弹哪个更重要%Which one is more important, Atomic Bomb or Atomic Clock?

    Institute of Scientific and Technical Information of China (English)

    李滚; 蔡成林; 袁海波

    2003-01-01

    @@ 1945年原子弹(Atomic Bomb)在广岛长崎爆炸之前,一般人很难理解原子弹的威力,原子钟(Atomic Clock)也不是大家都能一睹为快的;但是,原子弹和原子钟的概念的确已是家喻户晓.

  8. A case of squamous cell carcinoma on back skin developed 50 years after the exposure to the atomic bomb

    International Nuclear Information System (INIS)

    A 65-year-old man, who was exposed to an atomic bomb in Nagasaki 1945, developed an ulcerated tumor on his right upper back in 1995. A squamous cell carcinoma (SCC) was ascertained histopathologically, not only in the back skin but also the right axillary lymph node. Neither of his face nor back skin showed characteristic color changes responsible for actinic damage. Furthermore it is well-known that SCC occurs rarely in the trunk. These facts do not explain any susceptability of the occurrence of SCC to his back skin. Even though it has passed as many as fifty years after the tragedy by the atomic bomb, the exposure of the extremely huge amount of rays might cause a tumorigenesis. (author)

  9. An overview of the cancer mortality data on the atomic bomb survivors

    International Nuclear Information System (INIS)

    A brief description is given of the cancer mortality data at the Radiation Effects Research Foundation, with the aim of providing some general perspective on the extent of the excess cancer mortality, for those who may not be inclined to glean this information from the more comprehensive reports on the Life Span Study. In addition, a summary is given of the changes in dosimetry given by the recently installed DS86 system. Even a cursory view of these changes requires consideration of several factors; changes in air doses, in environmental and organ shielding factors, in the extent of the neutron component, and in effects of truncation of exposures at 6 Gy. Finally, a brief discussion is given of the evolution of radiogenic cancer risk estimates during the past 10-15 years. (author)

  10. Dedifferentiated Liposarcoma in the Retroperitoneum in an Atomic Bomb Survivor: Report of a Case

    OpenAIRE

    Nakamura, Yukio; Yumiba, Takeyoshi; Yamasaki, Yoshio; Momiyama, Takuya; Ito, Akira; Akamaru, Yusuke; Kasugai, Tsutomu

    2008-01-01

    A 76-year-old Japanese man was admitted to Kosei-Nenkin Hospital (Osaka, Japan) in November 2006; his chief complaint was a 10-kg loss in body weight over 3 months prior to admission. Abdominal computed tomography (CT) and dynamic magnetic resonance imaging (MRI) showed three masses in the retroperitoneum. The patient subsequently underwent surgery. The final histopathological diagnosis of tumors 1 and 2 was malignant fibrous histiocytoma of the retroperitoneum, and tumor 3 was a well-differe...

  11. Relationship between epidemiological factors and mortality among atomic bomb survivors, Hiroshima and Nagasaki

    International Nuclear Information System (INIS)

    Information concerning a number of environmental and individual factors was obtained by a mail questionnaire survey conducted in 1965 on 11,724 males aged 40 - 69 years in the JNIHABCC Life Span Study sample. In the ensuing 10 year period, some 2,834 deaths occurred in this population. This is a study of mortality as related to certain environmental and socioeconomic factors. The following observations may be made from this study: high death rates for all causes of death, cerebrovascular diseases, all malignant neoplasms, and stomach cancer were associated with lower socioeconomic status. Smoking was a significant risk factor for all causes of death, ischemic heart disease, all malignant neoplasms, stomach cancer, and cancers of the trachea, bronchus, and lung. The death rate for cardiovascular disease was significantly higher for those with higher body weight. A tendency was noted for higher death rates for all causes, all malignant neoplasms, lung cancer, and stomach cancer for those who were married earlier in life. This may be related to age at first marriage and social status. (author)

  12. "Divine" Intervention : American Religious Narratives of the Atomic Bombings, the End of the Pacific War, and the Allied Occupation

    OpenAIRE

    Hilary, Elmendorf

    2007-01-01

    The American memory of World War IPs end in the Pacific often portrays the bombings of Hiroshima and Nagasaki as a morally appropriate close to a horrifically violent war and suggests that "revisions" to that story, as witnessed at the Smithsonian's Air and Space Museum in 1995, obscure the reality of August 1945. Indeed, many Americans agreed with Truman's decision to introduce the world to atomic warfare, for they believed that it alone forced a reticent Japan to surrender. Using the lens o...

  13. Epidemiological studies on malignant lymphoma in Nagasaki city. Especially in relation to atomic bomb exposure

    Energy Technology Data Exchange (ETDEWEB)

    Maeda, Hiroshi; Jubashi, Toru; Matsuo, Takeshi; Shimokawa, Isao; Iwasaki, Keisuke; Ikeda, Takayoshi

    1987-06-01

    One hundred and eighty-two (182) cases of malignant lymphoma registered at the Nagasaki Tumor Registry from 1973 to the end of 1977 were studied in relation to atomic bomb exposure. No significant difference in the incidence of malignant lymphoma was found between the exposed and nonexposed groups. One hundred and thirty-one (131) cases excluding Hodgkin's disease and mycosis fungoides were histologically reviewed and classified according to Lymphoma Study Group (L.S.G.) and Working Formulation (W.F.) Classifications. Using the L.S.G. Classification, the three histological types(diffuse large cell, diffuse pleomorphic, and diffuse medium sized cell) occupied 72.7 % and 69.0 % of the exposed and nonexposed groups respectively. No significant difference in histological type between the exposed and nonexposed groups could be found with an exception of a slightly higher incidence of the diffuse medium sized cell type in the exposed group than in the nonexposed group. An evaluation of these results was made in comparison with the results in Hiroshima.

  14. The grave is wide: the Hibakusha of Hiroshima and Nagasaki and the legacy of the Atomic Bomb Casualty Commission and the Radiation Effects Research Foundation.

    Science.gov (United States)

    O'Malley, Gerald F

    2016-07-01

    Following the atomic bomb attacks on Japan in 1945, scientists from the United States and Japan joined together to study the Hibakusha - the bomb affected people in what was advertised as a bipartisan and cooperative effort. In reality, despite the best efforts of some very dedicated and earnest scientists, the early years of the collaboration were characterized by political friction, censorship, controversy, tension, hostility, and racism. The 70-year history, scientific output and cultural impact of the Atomic Bomb Casualty Commission and the Radiation Effects Research Foundation are described in the context of the development of Occupied Japan. PMID:27158765

  15. Investigation for effects of the atomic bomb on Nagasaki. {gamma}-ray measurements by Neher electrometer

    Energy Technology Data Exchange (ETDEWEB)

    Nakane, Ryohei [Nishina Memorial Foundation, Tokyo (Japan)

    2000-07-01

    Neher electrometer, invented as an equipment to investigate the relationship of cosmic ray and terrestrial magnetism in 1930s, had excellent properties as an equipment to measure {gamma}-ray outdoor and thus was used for measurement of radiation exposure after A-bomb explosion in Hiroshima and Nagasaki. In Nagasaki, measurement with this equipment enabled to locate the bombing center where the monument is standing now in the A-bomb Park. Measurement also revealed that the circular earth surface of 2000 m diameter had the induced radioactivity by neutron and that outside the area, the {gamma}-ray intensity was virtually similar to the background level. Ash composing of Pu and other fission products moved over Konpira-san on the west wind, most of which came down with rainfall onto around Nishiyama reservoir. In the A-bomb movies, there is a scene that Neher electrometer was working for {gamma}-ray measurement. (K.H.)

  16. Was Nazi Germany on the Road to an Atomic Bomb after all?

    Science.gov (United States)

    Lustig, Harry

    2006-04-01

    The story of Germany's efforts to develop a nuclear weapon during World War II is a much written about and contentious subject. However there has been agreement on one thing: by the end of the War the Germans had not achieved and were nowhere near to building a bomb. The dispute therefore has been about why Germany did not succeed. Now, from Germany, comes a challenge to this truth, in the provocative book Hitlers Bombe by Rainer Karlsch. The bombshell in Hitler's Bombe is the assertion that German scientists developed and tested a primitive fission and fusion nuclear weapon in March 1945. Karlsch bases this claim on testimony of witnesses in 1962, previously secret Russian documents, and the results of soil tests carried out in 2004 and 2005. However the physics is very murky and it seems out of the question that Germany had enough Uranium 235 or produced any Plutonium for a bomb. Hitlers Bombe also makes other, better documented and more credible revisionist assertions. These include the claim that the Nazis did continue to try to build a bomb after 1942 and that not Werner Heisenberg, but Kurt Diebner and Walther Gerlach were then the leaders of the German Uranium project. Karlsch's book therefore deserves more attention from physicists and historians than it has received in the United States.

  17. A histopathological study of lung cancer and other pulmonary malignant tumors in people exposed to the atomic bomb and non-exposed people in Hiroshima Pref

    International Nuclear Information System (INIS)

    During cancer is likely to be more prevalent among A-bomb survivors based on epidemiological statistics. The histopathological classification of lung cancer was studied in 238 cases (57 exposed and 181 non-exposed) with onset in a period 1973 - 1977. None of the exposed patients had carcinoid, adenoid cystic carcinoma or mucoepidermoid carcinoma probably originating in the bronchial gland. Most of the exposed patients were slightly older than the non-exposed. Adenocarcinoma was more frequent among the exposed. (Chiba, N.)

  18. External Radiation in Dolon Village Due to Local Fallout from the First USSR Atomic Bomb Test in 1949

    OpenAIRE

    Imanaka, Tetsuji; FUKUTANI, Satoshi; Yamamoto, Masayoshi; Sakaguchi, Aya; Hoshi, Masaharu

    2006-01-01

    Dolon village, located about 60 km from the border of the Semipalatinsk Nuclear Test Site, is known to be heavily contaminated by local fallout from the first USSR atomic bomb test in 1949. External radiation in Dolon was evaluated based on recent 137Cs data in soil and calculation of temporal change in the fission product composition. After fitting a log-normal distribution to the soil data, a 137Cs deposition of 32 kBq m-2, which corresponds to the 90th-percentile of the distribution, was t...

  19. Lack of effects of atomic bomb radiation on genetic instability of tandem-repetitive elements in human germ cells.

    OpenAIRE

    Kodaira, M; Satoh, C; Hiyama, K; Toyama, K.

    1995-01-01

    In a pilot study to detect the potential effects of atomic bomb radiation on germ-line instability, we screened 64 children from 50 exposed families and 60 from 50 control families for mutations at six minisatellite loci by using Southern blot analysis with Pc-1, lambda TM-18, ChdTC-15, p lambda 3, lambda MS-1, and CEB-1 probes. In the exposed families, one or both parents received a radiation dose > 0.01 Sv. Among the 64 children, only one child had parents who were both exposed. Thus, of a ...

  20. Why 159°?: a story about the dropping of the Hiroshima atom bomb

    Science.gov (United States)

    Prunty, Sean L.

    2015-04-01

    This paper presents an analysis of the evasive manoeuvre undertaken by the pilot of the Enola Gay aircraft following the dropping of the first uranium bomb. The pilot was instructed to make a 159° turn following the bomb’s release in order to acquire the greatest distance from the point at which the bomb explodes. Accordingly, the objective here is to investigate why the angle should be exactly 159°. The optimum flight-path to maximize the distance from the detonation point is analysed by considering the escape or exit angle taken by the aircraft following a turning-manoeuvre that points it directly away from the detonation site. A range of escape angles are predicted based on the requirement to exit the turning radius prior to detonation. By using information that appeared in a historical account of the event regarding the manoeuvre undertaken by the pilot following the release of the bomb, an estimate is made of the escape angle. Despite the fact that the result shows reasonable agreement with the value of 159°, some uncertainty is expressed as to the close coincidence obtained. In addition, the location of the aircraft and the time of arrival of the shock wave following detonation are also briefly discussed.

  1. Cancer incidence in children and young adults did not increase relative to parental exposure to atomic bombs.

    Science.gov (United States)

    Izumi, S; Koyama, K; Soda, M; Suyama, A

    2003-11-01

    We have examined whether parental exposure to atomic bomb radiation has led to increased cancer risks among the offspring. We studied 40,487 subjects born from May 1946 through December 1984 who were cancer-free in January 1958. One or both parents were in Hiroshima or Nagasaki at the time of the bombing and for childbirth. Using population-based tumor registry data we analyzed cancer incidence data from 1958 to 1997 by Cox regression models, and we examined the effects of both paternal and maternal irradiation with adjustment for city, sex, birth year, and migration. During follow-up, 575 solid tumor cases and 68 hematopoietic tumor cases were diagnosed. Median age at diagnosis was 39.7 years. Median doses were 143 millisierverts for 15,992 exposed (5+ millisierverts or unknown dose) fathers and 133 millisierverts for 10,066 exposed mothers. Cancer incidence was no higher for subjects with exposed parents than for the reference subjects (0-4 millisierverts), nor did the incidence rates increase with increasing dose. For 3568 subjects with two exposed parents, the adjusted risk ratio for all cancer was 0.97 (95% confidence interval 0.70-1.36). Because of the small number of cases, however, we cannot exclude an increase in cancer incidence at this time. PMID:14583774

  2. Radiation exposure and disease questionnaires of early entrants after the Hiroshima bombing.

    Science.gov (United States)

    Imanaka, Tetsuji; Endo, Satoru; Kawano, Noriyuki; Tanaka, Kenichi

    2012-03-01

    It is popularly known that people who entered into the ground-zero area shortly after the atomic bombings in Hiroshima and Nagasaki suffered from various syndromes similar to acute radiation effects. External exposures from neutron-induced radionuclides in soil have recently been reassessed based on DS02 calculations as functions of both distance from the hypocentres and elapsed time after the explosions. Significant exposure due to induced radiation can be determined for those who entered the area within 1000 m from the hypocentres shortly after the bombing. Although it was impossible to track the action of each of the survivors over the days or weeks following the bombings in order to make reliable dose estimates for their exposures to soil activation or fallout, four individuals among those early entrants were investigated here to describe useful information of what happened shortly after the bombing. PMID:21914640

  3. Immunogenetical study of the atomic-bombed patients of neoplastic diseases

    International Nuclear Information System (INIS)

    The immunogenetical backgrounds of 30 patients with neoplastic diseases (group I) and 30 with non-neoplastic diseases (group II) who were exposed to the A-bomb within 30 km of the center of explosion were studied using human leucocyte antigen (HLA), whose gene combines with Ir-gene, as an index. Eighty-four healthy, non-exposed persons (group III) were selected as controls. Regarding phenotype and genotype frequency, type A9 showed Aw24 and type A10 showed A26 in all cases. Except for Bw40, there was no significant difference among the groups (frequency of A9, I>II; that of A10, II< III). Bw40 was frequently observed in group I although it had racial specificity. There were 16 cases of Bw40 in group I (53.3%), 10 cases in group II (33.3%), and 23 cases in group III (27.3%). Further analysis of Bw40 revealed that Bw40.1 and Bw40.2 were more frequent in group I than in the control group. Bw40.3 was not observed in any of the groups. (Tsunoda, M.)

  4. An operated case with post-traumatic epilepsy following atomic bombing injury

    Energy Technology Data Exchange (ETDEWEB)

    Morioka, Takato; Nishio Shunji; Muraishi; Mitsuteru; Hisada, Kei; Takase, Keiichirou; Matsukado, Koichiro; Sasaki, Masayuki; Fukui, Masashi [Kyushu Univ., Fukuoka (Japan). Graduate School of Medicine; Ohta, Michiya

    1999-12-01

    The case was 54-years-old man who was bombed at 4-years old 1.5 km apart from the center of explosion in Hiroshima, and had intractable epilepsy after 10 years or more. He suffered from systemic convulsion from 18 years old and took anti-convulsant drugs from 23 years old. The frequency of seizure increased from once a half year to thrice 2 months for these 3-4 years. The attack mainly occurred at night, and it was generalized tonicoclonic convulsion accompanied with unconsciousness and urinary incontience. Valproate (1,800 mg) and clonazepam (1 mg) failed to control the attack, and then he was referred to author's hospital. By CT scanning, MRI and HMPAO-SPECT, the area around the ossified lesion in the right frontal lobe was considered the focus of the epilepsy, and the focus was removed on June 4, 1998. No neurodegeneration and convulsive seizure occurred after surgery. The ossified lesion was confirmed to be bone tissue containing osteoblasts from histological findings and was accompanied by severe gliosis to the brain surface. A large number of active astrocytes were found around the nerve cells in the cortex showing spine-like wave focus, but there were no significant changes in blood vessels in the brain. (K.H.)

  5. An operated case with post-traumatic epilepsy following atomic bombing injury

    International Nuclear Information System (INIS)

    The case was 54-years-old man who was bombed at 4-years old 1.5 km apart from the center of explosion in Hiroshima, and had intractable epilepsy after 10 years or more. He suffered from systemic convulsion from 18 years old and took anti-convulsant drugs from 23 years old. The frequency of seizure increased from once a half year to thrice 2 months for these 3-4 years. The attack mainly occurred at night, and it was generalized tonicoclonic convulsion accompanied with unconsciousness and urinary incontience. Valproate (1,800 mg) and clonazepam (1 mg) failed to control the attack, and then he was referred to author's hospital. By CT scanning, MRI and HMPAO-SPECT, the area around the ossified lesion in the right frontal lobe was considered the focus of the epilepsy, and the focus was removed on June 4, 1998. No neurodegeneration and convulsive seizure occurred after surgery. The ossified lesion was confirmed to be bone tissue containing osteoblasts from histological findings and was accompanied by severe gliosis to the brain surface. A large number of active astrocytes were found around the nerve cells in the cortex showing spine-like wave focus, but there were no significant changes in blood vessels in the brain. (K.H.)

  6. From the atomic bomb to the Landau Institute autobiography top non-secret

    CERN Document Server

    Khalatnikov, Isaak M

    2012-01-01

    The book is an expanded autobiography of the famous theoretical physicist Isaak Khalatnikov. He worked together with L.D. Landau at the Institute for Physical Problems lead by P.L. Kapitza. He is the co-author of L.D. Landau in a number of important works. They worked together in the frame of the so-called Nuclear Bomb Project. After the death of L.D. Landau, I.M. Khalatnikov initiated the establishment of the Institute for Theoretical Physics, named in honour of L.D. Landau, within the USSR Academy of Sciences. He headed this institute from the beginning as its Director. The institute inherited almost all traditions of the Landau scientific school and played a prominent role in the development of theoretical physics. So, this is a story about how the institute was created, how it worked, and about the life of the physicists in the "golden age" of the Soviet science. A separate chapter is devoted to today´s life of the institute and the young generation of physicists working now in science. It is an historic...

  7. Multi-model inference of adult and childhood leukaemia excess relative risks based on the Japanese A-bomb survivors mortality data (1950-2000).

    Science.gov (United States)

    Walsh, Linda; Kaiser, Jan Christian

    2011-03-01

    Some relatively new issues that augment the usual practice of ignoring model uncertainty, when making inference about parameters of a specific model, are brought to the attention of the radiation protection community here. Nine recently published leukaemia risk models, developed with the Japanese A-bomb epidemiological mortality data, have been included in a model-averaging procedure so that the main conclusions do not depend on just one type of model or statistical test. The models have been centred here at various adult and young ages at exposure, for some short times since exposure, in order to obtain specially computed childhood Excess Relative Risks (ERR) with uncertainties that account for correlations in the fitted parameters associated with the ERR dose-response. The model-averaged ERR at 1 Sv was not found to be statistically significant for attained ages of 7 and 12 years but was statistically significant for attained ages of 17, 22 and 55 years. Consequently, such risks when applied to other situations, such as children in the vicinity of nuclear installations or in estimates of the proportion of childhood leukaemia incidence attributable to background radiation (i.e. low doses for young ages and short times since exposure), are only of very limited value, with uncertainty ranges that include zero risk. For example, assuming a total radiation dose to a 5-year-old child of 10 mSv and applying the model-averaged risk at 10 mSv for a 7-year-old exposed at 2 years of age would result in an ERR=0.33, 95% CI: -0.51 to 1.22. One model (United Nations scientific committee on the effects of atomic radiation report. Volume 1. Annex A: epidemiological studies of radiation and cancer, United Nations, New York, 2006) weighted model-averaged risks of leukaemia most strongly by half of the total unity weighting and is recommended for application in future leukaemia risk assessments that continue to ignore model uncertainty. However, on the basis of the analysis

  8. Defence Science Research, Higher Education and the Australian Quest for the Atomic Bomb, 1945-60.

    Science.gov (United States)

    Reynolds, Wayne

    1997-01-01

    Recounts the efforts of the Australian government to create an atomic research and development program after World War II. Describes initial cooperation with Britain and the push for the transformation of Australian higher and secondary education in service of national scientific development. Discusses effects of the end of Commonwealth…

  9. Estimation of beta-ray skin dose from exposure to fission fallout from the Hiroshima atomic bomb.

    Science.gov (United States)

    Endo, Satoru; Tanaka, Kenichi; Shizuma, Kiyoshi; Hoshi, Masaharu; Imanaka, Tetsuji

    2012-03-01

    Beta-ray skin dose due to the fission fallout from the Hiroshima atomic bomb is potentially related to the epilation in the black rain area. The absorbed dose to the skin from beta-rays emitted by fission fallout has been estimated for an initial ¹³⁷Cs deposition of 1 kBq m⁻² on the ground at 0.5 h after the explosion. The estimated skin dose takes into account both external exposure from fission fallout radionuclides uniformly distributed in 1 mm of soil on the surface of the ground and from a 26 μm thickness of contaminated soil on the skin, using the Monte Carlo radiation transport code MCNP-4C. The cumulative skin dose for 1 month after the explosion is taken as the representative value. The estimated skin dose for an initial ¹³⁷Cs deposition of 1 kBq m⁻² was determined to be about 500 mSv. PMID:22042969

  10. Tissue kerma vs distance relationships for initial nuclear radiation from the atomic bombs Hiroshima and Nagasaki

    International Nuclear Information System (INIS)

    Initial nuclear radiation is comprised of prompt neutrons and prompt primary gamma rays from an exploding nuclear device, prompt secondary gamma rays produced by neutron interactions in the environment, and delayed neutrons and delayed fission-product gamma rays from the fireball formed after the nuclear device explodes. These various components must all be considered in establishing tissue kerma vs distance relationships which describe the decrease of initial nuclear radiation with distance in Hiroshima and Nagasaki. An interest in initial nuclear radiation at distances of as much as 2000 m from the hypocenter demands the use of discrete ordinates transport (DOT) techniques. The two-dimensional (2D) DOT-IV code developed at Oak Ridge National Laboratory (ORNL) was used to calculate the tissue kerma in an air-over-ground geometry from prompt neutrons and prompt primary gamma rays and from prompt secondary gamma rays produced in air and in soil. Data from the Los Alamos National Laboratory (LANL) were used as the source terms. The tissue kerma at ground level from delayed fission-product gamma rays and delayed neutrons, was investigated using the NUIDEA code developed by Science Applications, Inc., (SAI). This code incorporates very detailed models which can take into account such features as the immediate rise of the fireball, the rapid radioactive decay of fission-products in it, and the perturbation of the atmosphere by the explosion. Tissue kerma vs distance relationships obtained by summing results of these current state-of-the-art calculations will be discussed. Our results clearly show that the prompt secondary gamma rays and delayed fission-product gamma rays are the dominant components of the total tissue kerma from initial nuclear radiation of the atomic (or pure-fission) devices detonated over Hiroshima and Nagasaki. (author)

  11. Nuclide identification of alpha-emitters by autoradiography in specimen of atomic victims at Nagasaki

    OpenAIRE

    Shichijo, Kazuko; Takatsuji, Toshihiro; Yamamoto, Masayoshi; Nakashima, Masahiro

    2012-01-01

    The explosion of a plutonium Atomic bomb over Nagasaki city in Japan took place at 1102h on August 9, 1945. Radiation dose of A-bomb survivor is practically estimated from external radiation. The alpha particles can be disregarded science they travel only a short distance through air. Plutonium remaining in the soil at Nagasaki after 24yr has been determined in 1971. In the patients subjected to the Atomic bomb there was no evidence of the introduction of radioactive material. We have already...

  12. Statement by IAEA Director General on the 60th anniversary of the atomic bombing of Hiroshima and Nagasaki

    International Nuclear Information System (INIS)

    Full text: No one who has seen the victims, the film footage or photographs of the aftermath of the destruction of Hiroshima and Nagasaki at the end of World War II can fail to be horrified by the devastation that was wrought by the use of nuclear weapons. To date, Hiroshima and Nagasaki thankfully remain the only instances in which nuclear weapons have been used, and while it is difficult to speak of any good coming out of such ruin, it has always been hoped that the atomic bombing of Hiroshima and Nagasaki stand as constant reminders of why preventing the further use and proliferation of such weapons - and why nuclear disarmament leading to a nuclear-weapon-free world - is of utmost importance for the survival of humankind and planet Earth. The International Atomic Energy Agency born out of President Eisenhower's 'Atoms for Peace' vision, came at a time when the horrifying consequences and images of Hiroshima and Nagasaki were still fresh. Through its safeguards and verification system in support of the 1968 Treaty on the Non-Proliferation of Nuclear Weapons (NPT) and other similar non-proliferation agreements, the IAEA has done a great deal of work to help stem the tide of nuclear proliferation, while ensuring that the benefits of the peaceful uses of nuclear energy are made available to all those who want them. While the Agency can effectively verify compliance with non-proliferation undertakings, the value of these efforts can be better realized if they are reinforced by all other components of the nuclear non-proliferation and arms control regime, and accompanied by the political will and dialogue among concerned States to address underlying issues of security and confidence building with a view to achieving a system of collective security that no longer relies on nuclear weapons. A world without nuclear weapons remains a far-off goal and the world continues to be burdened with nearly thirty thousand nuclear warheads. The Comprehensive Nuclear-Test-Ban Treaty

  13. Estimation of accumulated doses due to incorporation of 90Sr from atomic bomb fall out in Mostik/Kazhakstan using simple models

    International Nuclear Information System (INIS)

    A full scale dose reconstruction is very costly and beyond the resources of a low budget study like the NATO-Semipalatinsk project. Nonetheless, a course estimate of the 90Sr doses accumulated in the years 1949-1995 has been tried based on two scenarios for the village Mostik close to the Semipalatinsk Nuclear Test Site. Scenario 1 assumes the observed body burden to be completely due to inhalation of radioactive particles at the time of the first Soviet atomic bomb test in 1949. The scenario can serve to get an order-of-magnitude estimate of the maximum dose possibly perceived by the incorporation of radiostrontium. The second scenario assumes the body burden to be completely due to ingestion, intake starting in 1949. Reality will be best described by something in between the two scenarios. Real mean accumulated doses from incorporation of 90r therefore will be somewhere between 1 and 22 mSv. The mean accumulated doses are well within the limits set by international recommendations. However, it has to be noted that incorporation of radiostrontium only accounts for part of the total dose. Therefore, dose reconstruction for the older inhabitants directly affected by the aboveground atomic weapons tests still needs further effort. To determine the late consequences of atmospheric atomic bomb tests for the population in the surroundings of the former nuclear weapons test site near Semipalatinsk, studies were performed by international cooperation between Kazakh, French, Czech and German institutions at two measuring locations (Mostik, Maisk) in Kazakhstan. A field mission in September 1995 assessed the radiological situation as far as external doses, environmental contamination and body burden of man are concerned. Results obtained proved, that presently the radiological situation in both villages is far from being a threat to the health of the population. Part of the assessment included 90Sr urinary excretion rates of people selected by age such that they were

  14. A man, a plan, a bomb

    Science.gov (United States)

    Harris, Margaret

    2015-03-01

    Was the atomic bombing of Hiroshima and Nagasaki justified? Was it necessary? Were there other - better - options available, either to the scientists who built the bombs or the generals who ordered them dropped? Nearly 70 years later, there are still no settled answers to these questions, and Tom Morton-Smith's new play Oppenheimer wisely avoids dwelling on the "what ifs" of atomic history.

  15. United States History Simulations, 1925-1964: The Scopes Trial, Dropping the Atomic Bomb on Japan, United States versus Alger Hiss, Mississippi--Summer 1964. ETC Simulations Number Three.

    Science.gov (United States)

    Hostrop, Richard W.

    This booklet provides instructions for simulation and role play of historical events in U.S. history from 1925-1964. Included for student research and participation are: the Scopes trial in Tennessee involving supporters of the teaching of evolution in the schools and of creationism; the decision to drop the atomic bomb on Japan ending World War…

  16. Radionuclides induced by environmental neutrons. Discovery of natural radioactive Eu and Co isotopes and their contribution to the evaluation of Atomic-bombing neutrons in Hiroshima and Nagasaki

    Energy Technology Data Exchange (ETDEWEB)

    Komura, Kazuhisa [Kanazawa Univ., Low Level Radioactivity Lab., Tatsunokuchi, Ishikawa (Japan); Yousef, Ahmed M. [South Valley Univ. (Egypt)

    2001-06-01

    Radioactive europium and cobalt isotopes induced by environmental neutrons have been discovered by low-background Ge detector installed in Ogoya underground laboratory. Specific activities of {sup 152}Eu, {sup 154}Eu and {sup 155}Eu and {sup 60}Co were measured for recent and old europium and cobalt reagents. Observed activities are 0.06-0.52 dpm g{sup -1} for {sup 152}Eu, 0.09-0.16 dpm g{sup -1} for {sup 154}Eu and 0.005-0.16 dpm g{sup -1} for {sup 155}Eu and 0.007-0.083 dpm g{sup -1} for {sup 60}Co. Contribution of natural {sup 152}Eu and {sup 60}Co in Atomic-bomb exposed samples are found to be negligible low and less than 10%, respectively. (author)

  17. History of radiation research. On radiation, radioactivity and radiation protection. Pt. 2. The sword of Damocles. Decade of the atomic bomb 1940-1950; Geschichte der Strahlenforschung. Ueber Strahlung, Radioaktivitaet und Strahlenschutz. T. 2. Das Damoklesschwert. Jahrzehnt der Atombombe: 1940-1950

    Energy Technology Data Exchange (ETDEWEB)

    Lindell, B.

    2006-07-01

    The book includes contributions with the following titles: Szilards bomb; the excess neutrons; Napoleon's successor; Einstein's letter; the interim year 1940; administration and research; the sailor from India; the production facilities; ''I am the death, destroyer of the world''; Heisenberg's bomb; from other horizons; Potsdam and the atomic bomb decision; Hiroshima and Nagasaki; the beginning of nuclear power; renewed contacts; epilogue.

  18. The story of an A-bomb by Oppenheimer

    Energy Technology Data Exchange (ETDEWEB)

    Song, Eun Yeong

    2005-06-15

    This book concentrates on an A-bomb by Oppenheimer. It is divided into eleven class, which are exile of excellent scientists, uranium atomic fission, situation the U.S. and Germany I, situation the U.S. and Germany II, air strike in pearl Harbor, plan for development of an A-bomb, military action to blow up heavy water plant, select on spot to drop an A-bomb, surrender and drop for an A-bomb and science of an A-bomb. This book is written to explain an A-bomb with form of storytelling.

  19. Genetic counseling of the cancer survivor

    International Nuclear Information System (INIS)

    Each year, tens of thousands of persons are diagnosed with cancer, are treated, and become survivors while still in their reproductive years. Their concerns about possible germ-cell damage as a result of life-saving radiation, chemotherapy, or both are plausible, based on evidence from animal models and from somatic cell mutations in human beings. A 40-year follow-up of survivors of the atomic bomb blasts in Japan showed no detectable genetic damage and suggested that the human gonad is more resistant to radiogenic mutation than the laboratory mouse. The pooled results of studying 12 series of offspring of cancer patients showed a 4% rate of major birth defects (similar to that of the general population) and an excess of fetal loss and low birth weight in offspring of women who received abdominal radiotherapy. According to preliminary evaluation of a new National Cancer Institute collaboration with five cancer registries, offspring of survivors of childhood cancers had no more birth defects than expected and, beyond an increase in probably familial cancers in children younger than 5, no overall increase in childhood cancer. Ideally, genetic and reproductive counseling should take place as soon as cancer is diagnosed (before therapy starts) and again when pregnancy is contemplated. 28 references

  20. Summary of the studies at ABCC-RERF concerning the late hematologic effects of atomic bomb exposure in Hiroshima and Nagasaki

    International Nuclear Information System (INIS)

    The most significant late hematologic effect of atomic bomb radiation exposure in the populations of Hiroshima and Nagasaki has been the increased occurrence of leukemia. The radiation effect for leukemia has disappeared in Nagasaki but slightly elevated rates still exist in Hiroshima. Multiple myeloma also is radiation-related, but there is only a suggestive relationship for malignant lymphoma. No evidence exists of a late radiation effect for primary disturbances of hematopoiesis in the absence of malignant disease. Somatic hematopoietic markers of previous radiation exposure include lymphocyte chromosomal aberrations and an increased frequency of mutant T-lymphocytes deficient in hypoxanthine phosphoribosyltransferase. A radiation effect also has been observed for the frequency of mutant erythrocytes lacking expression of glycophorin-A protein on the membrane. There is no evidence for radiation-induced disturbance of granulocyte function, but age-related accelerated decline in the immunological functions of T lymphocytes and age-related alteration in the number of certain subsets of circulating T and B lymphocytes appears to be radiation-related. A number of radiation-related hematology research proposals which might be considered for the future are included in this report. (author) 92 refs

  1. Reviews Equipment: Vibration detector Equipment: SPARK Science Learning System PS-2008 Equipment: Pelton wheel water turbine Book: Atomic: The First War of Physics and the Secret History of the Atom Bomb 1939-49 Book: Outliers: The Story of Success Book: T-Minus: The Race to the Moon Equipment: Fridge Rover Equipment: Red Tide School Spectrophotometer Web Watch

    Science.gov (United States)

    2010-03-01

    WE RECOMMEND Vibration detector SEP equipment measures minor tremors in the classroom SPARK Science Learning System PS-2008 Datalogger is easy to use and has lots of added possibilities Atomic: The First War of Physics and the Secret History of the Atom Bomb 1939-49 Book is crammed with the latest on the atom bomb T-Minus: The Race to the Moon Graphic novel depicts the politics as well as the science Fridge Rover Toy car can teach magnetics and energy, and is great fun Red Tide School Spectrophotometer Professional standard equipment for the classroom WORTH A LOOK Pelton wheel water turbine Classroom-sized version of the classic has advantages Outliers: The Story of Success Study of why maths is unpopular is relevant to physics teaching WEB WATCH IOP webcasts are improving but are still not as impressive as Jodrell Bank's Chromoscope website

  2. Primary liver carcinoma and liver cirrhosis in atomic bomb survivors, Hiroshima and Nagasaki, 1961-75, with special reference to HBs antigen

    International Nuclear Information System (INIS)

    During 1961-75, 128 cases of primary liver carcinoma (PLC) in the RERF Life Span Study extended sample and 301 cases of liver cirrhosis in the RERF Pathology Study sample were observed. All cases were assessed for hepatitis B surface antigen (HB sub(s) Ag) using orcein and aldehyde fuchsin staining. The incidence of PLC was 2.0 times higher in Nagasaki than in Hiroshima which was statistically significant, but the prevalence of liver cirrhosis showed hardly any difference between the two cities. Meaningful findings that may possibly explain the higher incidence of PLC in Nagasaki were that the presence of HB sub(s) Ag in the liver of patients without overt liver disease was 2.3 times higher in Nagasaki than in Hiroshima, and the prevalence of liver cirrhosis associated with PLC, especially that of posthepatitic cirrhosis with PLC, was almost 2.0 times higher in Nagasaki than in Hiroshima. In both cities a suggestive relationship of radiation dose with the prevalence of liver cirrhosis was noted but not with PLC. We believe that the higher incidence of PLC in Nagasaki is attributable to HB virus infection, though other factors, such as immunological competence affected by radiation, cannot be excluded. (author)

  3. Adult health study report 7. noncancer disease incidence in the atomic-bomb survivors, 1958-86 (examination cycles 1-14)

    International Nuclear Information System (INIS)

    Using the longitudinal data of the Adult Health Study (AHS) cohort collected during 1958-86, we examined for the first time the relationship between exposure to ionizing radiation and the incidence of 19 selected nonmalignant disorders. Diagnoses of the diseases were based on general laboratory tests, physical examinations, and histories taken during the biennial AHS examinations. The outcomes were encoded as three-digit International Classification of Diseases codes in the AHS data base, which served as the basis for case ascertainment. Statistically significant excess risk was detected for myoma uteri, chronic hepatitis and liver cirrhosis, and thyroid disease, defined broadly as the presence of one or more of certain noncancerous thyroid conditions. The finding for myoma uteri might be additional evidence indicating that benign tumor growths are possible effects of radiation exposure. An age-at-exposure effect was detected in nonmalignant thyroid disease, with increased risk for those exposed at ages ≤ 20 yr, but not for older persons. Thus, the AHS data also suggest that the thyroid gland in young persons is more radiosensitive not only to the development of thyroid malignancies, as shown in the most recent LSS report on cancer incidence, but also possibly to the development of nonmalignant disorders. Our findings hold independent of the dose effects observed for thyroid malignancies. No significant dose-response relationships were detected in any of our cardiovascular disease endpoints. Our analysis also suggests that new occurrences of lens opacity during 1958-86 are not increased with radiation dose among the AHS participants. Our results emphasize the utility and importance of the AHS in searching for the effects of acute exposure to ionizing radiation in noncancer diseases. (J.P.N.)

  4. Survivors and scientists: Hiroshima, Fukushima, and the Radiation Effects Research Foundation, 1975-2014.

    Science.gov (United States)

    Lindee, Susan

    2016-04-01

    In this article, I reflect on the Radiation Effects Research Foundation and its ongoing studies of long-term radiation risk. Originally called the Atomic Bomb Casualty Commission (1947-1975), the Radiation Effects Research Foundation has carried out epidemiological research tracking the biomedical effects of radiation at Hiroshima and Nagasaki for almost 70 years. Radiation Effects Research Foundation scientists also played a key role in the assessment of populations exposed at Chernobyl and are now embarking on studies of workers at the Fukushima Daiichi Nuclear Power Plant. I examine the role of estimating dosimetry in post-disaster epidemiology, highlight how national identity and citizenship have mattered in radiation risk networks, and track how participants interpreted the relationships between nuclear weapons and nuclear energy. Industrial interests in Japan and the United States sought to draw a sharp line between the risks of nuclear war and the risks of nuclear power, but the work of the Radiation Effects Research Foundation (which became the basis of worker protection standards for the industry) and the activism of atomic bomb survivors have drawn these two nuclear domains together. This is so particularly in the wake of the Fukushima disaster, Japan's 'third atomic bombing'. The Radiation Effects Research Foundation is therefore a critical node in a complex global network of scientific institutions that adjudicate radiation risk and proclaim when it is present and when absent. Its history, I suggest, can illuminate some properties of modern disasters and the many sciences that engage with them.

  5. Survivors and scientists: Hiroshima, Fukushima, and the Radiation Effects Research Foundation, 1975-2014.

    Science.gov (United States)

    Lindee, Susan

    2016-04-01

    In this article, I reflect on the Radiation Effects Research Foundation and its ongoing studies of long-term radiation risk. Originally called the Atomic Bomb Casualty Commission (1947-1975), the Radiation Effects Research Foundation has carried out epidemiological research tracking the biomedical effects of radiation at Hiroshima and Nagasaki for almost 70 years. Radiation Effects Research Foundation scientists also played a key role in the assessment of populations exposed at Chernobyl and are now embarking on studies of workers at the Fukushima Daiichi Nuclear Power Plant. I examine the role of estimating dosimetry in post-disaster epidemiology, highlight how national identity and citizenship have mattered in radiation risk networks, and track how participants interpreted the relationships between nuclear weapons and nuclear energy. Industrial interests in Japan and the United States sought to draw a sharp line between the risks of nuclear war and the risks of nuclear power, but the work of the Radiation Effects Research Foundation (which became the basis of worker protection standards for the industry) and the activism of atomic bomb survivors have drawn these two nuclear domains together. This is so particularly in the wake of the Fukushima disaster, Japan's 'third atomic bombing'. The Radiation Effects Research Foundation is therefore a critical node in a complex global network of scientific institutions that adjudicate radiation risk and proclaim when it is present and when absent. Its history, I suggest, can illuminate some properties of modern disasters and the many sciences that engage with them. PMID:27263236

  6. Skin dose from neutron-activated soil for early entrants following the A-bomb detonation in Hiroshima: contribution from beta and gamma rays.

    Science.gov (United States)

    Tanaka, Kenichi; Endo, Satoru; Imanaka, Tetsuji; Shizuma, Kiyoshi; Hasai, Hiromi; Hoshi, Masaharu

    2008-07-01

    Epilation was reported among atomic bomb survivors in Hiroshima and Nagasaki, including "early entrance survivors" who entered the cities after the bombings. The absorbed dose to the skin by neutron-activated soil via beta and gamma rays has been estimated in a preliminary fashion, for these survivors in Hiroshima. Estimation was done for external exposures from activated soil on the ground as well as skin and hair contamination from activated soil particles, using the Monte Carlo radiation transport code MCNP-4C. Assuming 26 mum thickness of activated soil on the skin as an example, the skin dose was estimated to be about 0.8 Gy, for an exposure scenario that includes the first 7 days after the bombing at 1 m above the ground at the hypocenter. In this case, 99% of the total skin dose came from activated radionuclides in the soil, i.e., 0.19 and 0.63 Gy due to beta and gamma rays, respectively. In contrast, contribution to skin dose due to skin contamination with soil particles was found to be about 1%. To make it comparable to the exposure by neutron-activated soil on the ground, a soil thickness on the skin of about 1 mm would be required, which seems to be difficult to keep for a long time. Fifty-five percent of the 7-day skin dose was delivered during the first hour after the bombing. Our estimates of the skin dose are lower than the conventionally reported threshold of 2 Gy for epilation. It should be noted, however, that the possibility of more extreme exposure scenarios for example for entrants who received much heavier soil contamination on their skin cannot be excluded. PMID:18496704

  7. Meta-analysis of second cancer risk after radiotherapy among childhood cancer survivors

    International Nuclear Information System (INIS)

    Cancer risks among childhood cancer survivors following radiotherapy have not yet been well characterised in terms of radiation dose. A meta-analysis of studies on the excess relative risk per gray (ERR) of second cancer was conducted previously; unfortunately, the small number of eligible studies restricted quantitative evaluations. To solve this problem, a statistical method to calculate ERR estimates from other estimates was developed, and a meta-analysis was conducted again. The PubMed database was searched and 26 relevant studies were identified. ERR estimates were available in 15 studies, and for the other 11 studies, the regression-based model was used to calculate ERR estimates from other estimates. The overall ERR estimate was 0.40, which was much lower than that of atomic bomb survivors exposed as young children. Heterogeneity of the risk among studies was suggested, and a further study is needed to explore the heterogeneity among studies. (authors)

  8. Risk of cancer among in utero children exposed to A-bomb radiation, 1950-84

    International Nuclear Information System (INIS)

    This study examines the risk of cancer (incidence) over a period of 40 years among the inutero exposed survivors of the atomic bombing of Hiroshima and Nagasaki, and adds eight years of follow-up to a previous report which was confined to mortality. Only two cases of childhood cancer were observed among these survivors in the first 14 years of life; both had been heavily exposed. Subsequent cancers have all been of the adult type. Not only did the observed cancers occur earlier in the ≥ 0.30 Gy dose group than in the 0 Gy dose group but the incidence continues to increase and the crude cumulative incidence rate, 40 years after the A-bombing, is 3.9-fold greater in the ≥ 0.30 Gy group. In the observation period 1950-84, based on the absorbed dose to the mother's uterus, as estimated by the Dosimetry System 1986 (DS86), the relative risk of cancer at 1 Gy is 3.77 with a 95% confidence interval of 1.14-13.48. For the entire ≥ 0.01 Gy dose group the average excess risk per 104 person-year-gray is 6.57 (0.07-14.49) and the estimated attributable risk is 40.9% (2.9%-90.2%). These results, when viewed in the perspective of fetus doses, suggest that susceptibility to radiation-induced cancers is higher in pre- than in postnatally exposed survivors (at least those exposed as adults). However, definitive conclusions must await further follow-up studies. (author)

  9. The human sex odds at birth after the atmospheric atomic bomb tests, after Chernobyl, and in the vicinity of nuclear facilities: comment.

    Science.gov (United States)

    Krämer, Walter

    2012-05-01

    The recent claim made in this journal that nuclear bomb tests and the Chernobyl disaster caused distortions in the secondary sex ratio is shown to be a likely artifact of data mining, misused statistics, and misreading of the evidence. In particular, the concept of statistical "significance" and its limitations do not seem to be fully understood, and important confounding factors have not been accounted for.

  10. The human sex odds at birth after the atmospheric atomic bomb tests, after Chernobyl, and in the vicinity of nuclear facilities: comment.

    Science.gov (United States)

    Krämer, Walter

    2012-05-01

    The recent claim made in this journal that nuclear bomb tests and the Chernobyl disaster caused distortions in the secondary sex ratio is shown to be a likely artifact of data mining, misused statistics, and misreading of the evidence. In particular, the concept of statistical "significance" and its limitations do not seem to be fully understood, and important confounding factors have not been accounted for. PMID:22076251

  11. Determinação de As em amostras orgânicas de interesse ambiental por espectrometria de absorção atômica com atomização eletrotérmica após combustão em bomba de O2 Determination of As in environmental organic samples by atomic absorption spectrometry with electrothermal atomization after O2 bomb combustion

    Directory of Open Access Journals (Sweden)

    Vera Maria da Costa Dias

    2003-10-01

    Full Text Available The toxicity of the major As species present in the environment justifies the effort for quantifying the element in environmental organic samples, which can vary from animal and vegetal tissues to coal and industrial residues. This paper comments about the applicability of the O2 bomb digestion, as a general procedure for all environmental organic materials. A rapid and straightforward method is suggested, which consists in burning the sample in the bomb at high O2 pressure, dissolving the vapours in diluted HNO3 and determining As in the resulting solution by atomic absorption spectrometry with electrothermal atomization. The method was applied to certified materials and plant samples.

  12. Bomb apologetics: Farm Hall, August 1945

    Energy Technology Data Exchange (ETDEWEB)

    Bernstein, J. [Professor of Physics at Stevens Institute of Technology in Hoboken New Jersey (United States); Cassidy, D. [Professor at Hofstra University, in Hempstead, New York (United States)

    1995-08-01

    On hearing the news from Hiroshima, the incredulous internees came up with a self-serving story to explain their failures in nucleus research: To keep Hitler from winning, they had deliberately not developed the atomic bomb. {copyright} 1995 {ital American} {ital Institute} {ital of} {ital Physics}.

  13. The Hiroshima/Nagasaki Survivor Studies: Discrepancies Between Results and General Perception.

    Science.gov (United States)

    Jordan, Bertrand R

    2016-08-01

    The explosion of atom bombs over the cities of Hiroshima and Nagasaki in August 1945 resulted in very high casualties, both immediate and delayed but also left a large number of survivors who had been exposed to radiation, at levels that could be fairly precisely ascertained. Extensive follow-up of a large cohort of survivors (120,000) and of their offspring (77,000) was initiated in 1947 and continues to this day. In essence, survivors having received 1 Gy irradiation (∼1000 mSV) have a significantly elevated rate of cancer (42% increase) but a limited decrease of longevity (∼1 year), while their offspring show no increased frequency of abnormalities and, so far, no detectable elevation of the mutation rate. Current acceptable exposure levels for the general population and for workers in the nuclear industry have largely been derived from these studies, which have been reported in more than 100 publications. Yet the general public, and indeed most scientists, are unaware of these data: it is widely believed that irradiated survivors suffered a very high cancer burden and dramatically shortened life span, and that their progeny were affected by elevated mutation rates and frequent abnormalities. In this article, I summarize the results and discuss possible reasons for this very striking discrepancy between the facts and general beliefs about this situation. PMID:27516613

  14. Atomic secrecy

    International Nuclear Information System (INIS)

    An article, The H-Bomb Secret: How We Got It, Why We're Telling It, by Howard Morland was to be published in The Progressive magazine in February, 1979. The government, after learning of the author's and the editors' intention to publish the article and failing to persuade them to voluntarily delete about 20% of the text and all of the diagrams showing how an H-bomb works, requested a court injunction against publication. Acting under the Atomic Energy Act of 1954, US District Court Judge Robert W. Warren granted the government's request on March 26. Events dealing with the case are discussed in this publication. Section 1, Progressive Hydrogen Bomb Case, is discussed under the following: Court Order Blocking Magazine Report; Origins of the Howard Morland Article; Author's Motives, Defense of Publication; and Government Arguments Against Disclosure. Section 2, Access to Atomic Data Since 1939, contains information on need for secrecy during World War II; 1946 Atomic Energy Act and its effects; Soviet A-Bomb and the US H-Bomb; and consequences of 1954 Atomic Energy Act. Section 3, Disputed Need for Atomic Secrecy, contains papers entitled: Lack of Studies on H-Bomb Proliferation; Administration's Position on H-Bombs; and National Security Needs vs Free Press

  15. What Are the Radiation Risks from CT?

    Science.gov (United States)

    ... by some of the Japanese survivors of the atomic bombs. These survivors, who are estimated to have experienced ... by some of the Japanese survivors of the atomic bombs. These survivors, who are estimated to have experienced ...

  16. A-bomb and skin injury

    International Nuclear Information System (INIS)

    Injury and influence in the skin given by A-bomb are reviewed from the dermatological aspect. As an acute injury, primary and secondary thermal burns, flash and flame, respectively, are generally caused by high-energy heat. More than 90% people present within 1 km diameter area of the hypocenter died in a week and about 30% of whom did due to burns. Alopecia appeared in those who had been exposed to A-bomb radiation within 2.5 km diameter region of the hypocenter in Hiroshima and Nagasaki, and purpura, an important measure of radiation injury, occurred maximally 20-30 days after explosion in most of those people above. Late injury involves keloid and malignant skin tumor. The former, hypertrophic scar, was seen mainly in the curing process of the burns in 60-80% and was of somewhat different morphology after flash and flame injuries. In 1987, the correlation between the incidence of skin cancer and exposed dose was recognized in 20,348 survivors in Nagasaki. In the period from 1958 to 1987, the incidence of basal cell carcinoma was found increased in the comparative studies of about 90,000 people consisting of survivors and non-exposed control. Skin examination is pointed out from the aspect to be important in those people exposed to the higher radiation dose than general population, like workers in the nuclear power plant and medical field as well as in those enrolled in a nuclear accident. (R.T.)

  17. Cluster bomb ocular injuries

    Directory of Open Access Journals (Sweden)

    Ahmad M Mansour

    2012-01-01

    Full Text Available Purpose: To present the visual outcomes and ocular sequelae of victims of cluster bombs. Materials and Methods: This retrospective, multicenter case series of ocular injury due to cluster bombs was conducted for 3 years after the war in South Lebanon (July 2006. Data were gathered from the reports to the Information Management System for Mine Action. Results: There were 308 victims of clusters bombs; 36 individuals were killed, of which 2 received ocular lacerations and; 272 individuals were injured with 18 receiving ocular injury. These 18 surviving individuals were assessed by the authors. Ocular injury occurred in 6.5% (20/308 of cluster bomb victims. Trauma to multiple organs occurred in 12 of 18 cases (67% with ocular injury. Ocular findings included corneal or scleral lacerations (16 eyes, corneal foreign bodies (9 eyes, corneal decompensation (2 eyes, ruptured cataract (6 eyes, and intravitreal foreign bodies (10 eyes. The corneas of one patient had extreme attenuation of the endothelium. Conclusions: Ocular injury occurred in 6.5% of cluster bomb victims and 67% of the patients with ocular injury sustained trauma to multiple organs. Visual morbidity in civilians is an additional reason for a global ban on the use of cluster bombs.

  18. Are IRIS Bombs Connected to Ellerman Bombs?

    Science.gov (United States)

    Tian, Hui; Xu, Zhi; He, Jiansen; Madsen, Chad

    2016-06-01

    Recent observations by the Interface Region Imaging Spectrograph (IRIS) have revealed pockets of hot gas (∼2–8 × 104 K) potentially resulting from magnetic reconnection in the partially ionized lower solar atmosphere (IRIS bombs; IBs). Using joint observations between IRIS and the Chinese New Vacuum Solar Telescope, we have identified 10 IBs. We find that 3 are unambiguously and 3 others are possibly connected to Ellerman bombs (EBs), which show intense brightening of the extended {{{H}}}α wings without leaving an obvious signature in the {{{H}}}α core. These bombs generally reveal the following distinct properties: (1) the O iv 1401.156 Å and 1399.774 Å lines are absent or very weak; (2) the Mn i 2795.640 Å line manifests as an absorption feature superimposed on the greatly enhanced Mg ii k line wing; (3) the Mg ii k and h lines show intense brightening in the wings and no dramatic enhancement in the cores; (4) chromospheric absorption lines such as Ni ii 1393.330 Å and 1335.203 Å are very strong; and (5) the 1700 Å images obtained with the Atmospheric Imaging Assembly on board the Solar Dynamics Observatory reveal intense and compact brightenings. These properties support the formation of these bombs in the photosphere, demonstrating that EBs can be heated much more efficiently than previously thought. We also demonstrate that the Mg ii k and h lines can be used to investigate EBs similarly to {{{H}}}α , which opens a promising new window for EB studies. The remaining four IBs obviously have no connection to EBs and they do not have the properties mentioned above, suggesting a higher formation layer, possibly in the chromosphere.

  19. Are IRIS bombs connected to Ellerman bombs?

    CERN Document Server

    Tian, Hui; He, Jiansen; Madsen, Chad

    2016-01-01

    Recent observations by the Interface Region Imaging Spectrograph (IRIS) have revealed pockets of hot gas ($\\sim$2--8$\\times$10$^{4}$ K) potentially resulting from magnetic reconnection in the partially ionized lower solar atmosphere (IRIS bombs; IBs). Using joint observations between IRIS and the Chinese New Vacuum Solar Telescope, we have identified ten IBs. We find that three are unambiguously and three others are possibly connected to Ellerman bombs (EBs), which show intense brightening of the extended H$_{\\alpha}$ wings without leaving an obvious signature in the H$_{\\alpha}$ core. These bombs generally reveal the following distinct properties: (1) The O~{\\sc{iv}}~1401.156\\AA{} and 1399.774\\AA{} lines are absent or very weak; (2) The Mn~{\\sc{i}}~2795.640\\AA{} line manifests as an absorption feature superimposed on the greatly enhanced Mg~{\\sc{ii}}~k line wing; (3) The Mg~{\\sc{ii}}~k and h lines show intense brightening in the wings and no dramatic enhancement in the cores; (4) Chromospheric absorption lin...

  20. Details of Nazis' A-Bomb program surface

    CERN Multimedia

    Glanz, J

    2002-01-01

    Werner Heisenberg, leader of the Nazi atomic bomb program, revealed the projects existence to Niels Bohr in a meeting in Copenhagen in 1941. But contrary to several historical accounts of the meeting, Heisenberg never expressed moral qualms about building a bomb for Hitler nor hinted that he might be willing to sabotage the project, according to secret documents cited in a London newspaper yesterday (2 pages).

  1. 《原子弹的初光:原子时代初期美国人的思想与文化》书评%Review on"First light of atomic bomb:the thought and culture of American in early atomic age"

    Institute of Scientific and Technical Information of China (English)

    孙博

    2012-01-01

      The writing of Bowyer"First light of atomic bomb". As the name implies, is a new cultural history and the history of ideas of the works. The book uses the extremely rich data to build the Americans’ perception, psychology and thinking on the atomic bomb from 1945 to 1950, and use of comprehensive information, rigorous attitude, makes the book read like watching America's"Qingmingshanghetu"in fifty's of the last century,.%  鲍耶的著作《原子弹的初光》。顾名思义,是一部新文化史和思想史的著作。全书采用了极其丰富的资料重新构建了1945年至1950年美国人对原子弹的看法、心理与思考,且使用资料之全面,编选之精细,态度之严谨,使得本书让人读起来犹如观看一幅上世纪五十年代末美国的“清明上河图”。

  2. Imaginary Savior: the image of the nuclear bomb in Korea, 1945-1960.

    Science.gov (United States)

    Kim, Dong-Won

    2009-01-01

    Two atomic bombs dropped on Hiroshima and Nagasaki in August 1945 brought the unexpected liberation of Korea from the 35-year Japanese occupation. Koreans therefore had a very favorable and positive image of the nuclear bomb and nuclear energy from the beginning. The image of the nuclear bomb as "savior" was strengthened during the Korean War when the United States openly mentioned the possible use of the nuclear bomb against North Korean and Chinese military. After the end of the Korean War in July 1953 South Koreans strongly supported the development of the nuclear bomb in order to deter another North Korean invasion. When the US government provided South Korea with a research nuclear reactor in the late 1950s, most South Koreans hailed it as the first step to developing their own nuclear bomb. This paper will analyze how and why the savior image of the nuclear bomb originated and spread in Korea during the 1950s.

  3. Imaginary Savior: the image of the nuclear bomb in Korea, 1945-1960.

    Science.gov (United States)

    Kim, Dong-Won

    2009-01-01

    Two atomic bombs dropped on Hiroshima and Nagasaki in August 1945 brought the unexpected liberation of Korea from the 35-year Japanese occupation. Koreans therefore had a very favorable and positive image of the nuclear bomb and nuclear energy from the beginning. The image of the nuclear bomb as "savior" was strengthened during the Korean War when the United States openly mentioned the possible use of the nuclear bomb against North Korean and Chinese military. After the end of the Korean War in July 1953 South Koreans strongly supported the development of the nuclear bomb in order to deter another North Korean invasion. When the US government provided South Korea with a research nuclear reactor in the late 1950s, most South Koreans hailed it as the first step to developing their own nuclear bomb. This paper will analyze how and why the savior image of the nuclear bomb originated and spread in Korea during the 1950s. PMID:20518158

  4. Effects of sera obtained from electrically charged human body on action potential of giant axon of squid and its relationship to the therapy of the atomic bomb sequela, (2)

    International Nuclear Information System (INIS)

    The giant axon of squid was perfused for 20 min with sea water and four kinds of mixture of sera and sea water (1:2), and spike potential of the axon was compared by using a computer. Perfusates used were sea water, sera obtained before electric charge to the human body (pre-sera), sera obtained from the human body electrically charged with -300 volt (negative sera), and sera obtained from the human body electrically charged with +300 volt (positive sera). Negative sera increased action potential of the axon, and positive sera decreased action potential of the axon. These results revealed that negative sera have a greater deal of e-, and positive sera have less quantity of e- than pre-sera, suggesting the involvement of e- in the action potential of the axon. Microtubules in the inner part of the axonal membrane and cell membrane seem to be most greatly related to e-; however, changes in the other axons, cell membrane and protoplasm should also be taken into account. These experimental results seem to be of great value, particularly providing useful information on the treatment for late effects (cell damage) of atomic bombing or burn. (Namekawa, K.)

  5. Collection of trace evidence of explosive residues from the skin in a death due to a disguised letter bomb. The synergy between confocal laser scanning microscope and inductively coupled plasma atomic emission spectrometer analyses.

    Science.gov (United States)

    Turillazzi, Emanuela; Monaci, Fabrizio; Neri, Margherita; Pomara, Cristoforo; Riezzo, Irene; Baroni, Davide; Fineschi, Vittorio

    2010-04-15

    In most deaths caused by explosive, the victim's body becomes a depot for fragments of explosive materials, so contributing to the collection of trace evidence which may provide clues about the specific type of device used with explosion. Improvised explosive devices are used which contain "homemade" explosives rather than high explosives because of the relative ease with which such components can be procured. Many methods such as chromatography-mass spectrometry, scanning electron microscopy, stereomicroscopy, capillary electrophoresis are available for use in the identification of explosive residues on objects and bomb fragments. Identification and reconstruction of the distribution of explosive residues on the decedent's body may give additional hints in assessing the position of the victim in relation to the device. Traditionally these residues are retrieved by swabbing the body and clothing during the early phase, at autopsy. Gas chromatography-mass spectrometry and other analytical methods may be used to analyze the material swabbed from the victim body. The histological examination of explosive residues on skin samples collected during the autopsy may reveal significant details. The information about type, quantity and particularly about anatomical distribution of explosive residues obtained utilizing confocal laser scanning microscope (CLSM) together with inductively coupled plasma atomic emission spectrometer (ICP-AES), may provide very significant evidence in the clarification and reconstruction of the explosive-related events.

  6. Effect of low dose of A-bomb radiation on risk of death

    International Nuclear Information System (INIS)

    Among about 100,000 A-bomb survivors registered at Nagasaki University School of Medicine, 290 male subjects exposed to 50-149 cGy showed significantly lower mortality from non-cancer death than age-matched unexposed males. This was deduced from the fitting of a U-shaped dose-response relationship. (author)

  7. Study into epilation among residents and "black rain" fallout in the Manose district of Nagasaki City following dropping of the atomic bomb

    OpenAIRE

    Honda, Kouya

    2012-01-01

    It became clear from the testimony of residents that a considerable amount of black rain fell in the Manose district of Nagasaki City . The Manose district is a small settlement located in a mountainous area approximately 7.5 km northwest from the hypocenter. Not only did black rain fall, but the residents experienced high incidence of epilation. Soil sampling aimed at detecting plutonium originating from the atomic blast was conducted primarily in the Manose district in July 2011. The black ...

  8. Proceedings of 42nd Research Society for the Late Effects of the A-Bomb

    Energy Technology Data Exchange (ETDEWEB)

    Sasaki, Hideo [Hiroshima Atomic Bomb Casualty Council Health Management and Promotion Center (Japan); Nakane, Yoshibumi [Nagasaki Univ. Graduate School of Bio-medicine (Japan); Suzuki, Gen [Radiation Effect Research Foundation, Hiroshima (JP)] [and others

    2002-03-01

    This issue is the collection of study papers presented in the meeting in the title: the special review lecture concerning the epidemiological evidences of multiple myeloma examination in A-bomb survivors (12-year study), the symposium concerning the medical care of A-bomb survivors in 21st century (5 presentations of medical care for the aged survivors, psychiatric approach and psychological care, future clinical studies and survivors' children in RERF, epidemiological study on the late effect of A-bomb radiation, and international cooperation of medical care in Semipalatinsk), and 51 general presentations. The general presentations included 1 article concerning external dose estimation in Ust-Kamenogorsk city, 7, the health care and management of the survivors, 9, cancer and its risk assessment (lung, uterine, stomach, liver and bone marrow), 1, arteriosclerosis, 10, health physics studies in relation to Semipalatinsk and/or Chernobyl (mainly on thyroid cancer), 2, experimental animal studies of thyroid cancer and malformation, 9, genomic studies like gene rearrangement, REV1 SNPs, function analysis and regeneration medicine, and 12, histological and cytological studies concerning DNA/RNA extraction, gene expression, signal transduction and immune system. (K.H.)

  9. Proceedings of 42nd Research Society for the Late Effects of the A-Bomb

    International Nuclear Information System (INIS)

    This issue is the collection of study papers presented in the meeting in the title: the special review lecture concerning the epidemiological evidences of multiple myeloma examination in A-bomb survivors (12-year study), the symposium concerning the medical care of A-bomb survivors in 21st century (5 presentations of medical care for the aged survivors, psychiatric approach and psychological care, future clinical studies and survivors' children in RERF, epidemiological study on the late effect of A-bomb radiation, and international cooperation of medical care in Semipalatinsk), and 51 general presentations. The general presentations included 1 article concerning external dose estimation in Ust-Kamenogorsk city, 7, the health care and management of the survivors, 9, cancer and its risk assessment (lung, uterine, stomach, liver and bone marrow), 1, arteriosclerosis, 10, health physics studies in relation to Semipalatinsk and/or Chernobyl (mainly on thyroid cancer), 2, experimental animal studies of thyroid cancer and malformation, 9, genomic studies like gene rearrangement, REV1 SNPs, function analysis and regeneration medicine, and 12, histological and cytological studies concerning DNA/RNA extraction, gene expression, signal transduction and immune system. (K.H.)

  10. (In)security factor atomic bomb. An analysis of the crisis with the Iranian nuclear program; (Un-)Sicherheitsfaktor Atombombe. Eine Analyse der Krise um das iranische Nuklearprogramm

    Energy Technology Data Exchange (ETDEWEB)

    Bock, Andreas [Augsburg Univ. (Germany). Lehrstuhl fuer Friedens- und Konfliktforschung

    2012-04-15

    Iran is a rational actor in the international politics that decides on the basis of the perception of threat. Iran's security situation is comparable with that of Israel with the rational consequence to rely on the atomic program with respect to deterrence and self-defense. The solution of the Iran crisis is basically dependent on a change of the perception of threat. A military act against the Iranian nuclear facilities would be counterproductive, would only slowing down the program but not prevent further activities. In fact a military act would enhance the perception of threat. For the analysis of the Iran crises the author used the Cuba crisis as blueprint, were mislead perceptions were responsible for the escalation.

  11. DBA Survivor

    CERN Document Server

    LaRock, Thomas

    2010-01-01

    DBA Survivor is a book to help new DBAs understand more about the world of database administration. More and more people are moving into the DBA profession, and many are looking for a getting-started guide. Blogs are written about how to be an exceptional DBA and what to do in your first 100 days. This book takes a different approach, injecting some humor into helping you understand how to hit the ground running, and most importantly how to survive as a DBA. And it's not just survival that matters. Author Thomas LaRock wants much more for you than mere survival. He wants you to have excellence

  12. A Confusion of Signals: James Franck, the Chicago Scientists and Early Efforts to Stop the Bomb

    Science.gov (United States)

    Villa, Brian Loring

    1975-01-01

    If the scientists working on the Manhattan Project had realized the consequences of the atomic bomb earlier, formulated their recommendations more precisely, and approached the statesmen in time, American policy on use and control of the bomb might well have been different. (Author/BT)

  13. Human bombing - a religious act

    OpenAIRE

    Mohammed Ilyas

    2014-01-01

    The issue of human bombing, which is popularly known as suicide bombing has become important in the Western world since the 9/11 and 7/7 attacks. Since then the issue of human bombing has become important to academia, the media, and security experts. This interest has resulted in much literature attempting to explain why human bombings take place and what motivates the bombers; for instance, the works of Gambetta (2006); Pape (2006); Merari (2010); Hafez (2006, 2007); Wright (2007); Bloom (20...

  14. Epidemiologic study of breast cancer in a-bomb survivors

    International Nuclear Information System (INIS)

    A case-control study was made on female breast cancer cases and their matched controls in the Life Span Study sample. The index cases were detected during 1958-69 among the 251 breast cancer cases ascertained originally by McGregor et al. The purpose of this study was to define the epidemiologic risk factors of breast cancer among Japanese women, to test for radiation effects in the presence of other risk factors, and to search for interactions. The survey was conducted by interview at home visits for those residing in the Hiroshima and Nagasaki areas, and by mail survey for others. The interview was carried out by several trained interviewers. Information concerning suspected risk factors of breast cancer, such as familial history, education, age at menarche and menopause, marital history, reproductive history, history of breast feeding, etc., was collected for both index cases and controls. Out of 183 original pairs, analysis was made on 164 pairs with available information for both the index and control, using the method of matched samples described by Mantel and Haenszel. There was enhancement of risk for those exposed to high radiation dose (100 rad or more). Although most major results were similar to those of previous studies, a significant increase of risk was observed among those under one of the following conditions: actual duration of marriage was less than 10 years; number of pregnancies was two or less; and age at delivery of first live born child was 27 or over. These factors had a mutual interrelationship and cases with two or more of these risk factors showed higher risk than those with one. Additive interrelationship was demonstrated between radiation dose and these marital or reproductive risk factors in elevating the relative risk of breast cancer. (author)

  15. Ellerman bombs: fallacies, fads, usage

    CERN Document Server

    Rutten, Robert J; van der Voort, Luc H M Rouppe; Sütterlin, Peter; Vitas, Nikola

    2013-01-01

    Ellerman bombs are short-lived brightenings of the outer wings of Halpha that occur in active regions with much flux emergence. We point out fads and fallacies in the extensive Ellerman bomb literature, discuss their appearance in various spectral diagnostics, and advocate their use as indicators of field reconfiguration in active-region topography using AIA 1700 A images.

  16. Late effects of radiation: Neglected aspects of A-bomb data

    Energy Technology Data Exchange (ETDEWEB)

    Stewart, A.M.; Kneale, G.W. [Dept. of Public Health and Epidemiology, Birmingham Univ., Edgbaston (United Kingdom)

    2001-07-01

    Both from the Oxford Survey of Childhood Cancers, and from recent surveys of nuclear workers at Hanford and Oak Ridge, have come risk estimates for cancer effects of radiation that are much higher than the ones based on a life span study cohort of A-bomb survivors. Furthermore, relations between the age when exposed and the cancer risk were radically different for workers and survivors. Therefore, there was clearly a need to discover whether the LSS cohort was a normal homogeneous population or, alternatively, whether persons who had shown signs of acute radiation effects constituted a special, radiosensitive subgroup of survivors. Statistical tests of the alternative hypotheses revealed significant differences between 63,072 survivors who denied having any of the following injuries and 2,601 survivors who claimed two or more of them: radiation, burns, purpura, oropharyngeal lesions and epilation. The tests also showed that the group differences were largely the result of exposures before 10 or after 55 years of age being exceptionally dangerous; that cancer was not the only late effect of the A-bomb radiation, and that it was only among the survivors with multiple injuries that the leukaemia death rate was exceptionally high. (orig.)

  17. No blackhole and no atomic bomb

    Science.gov (United States)

    Shin, Philip

    2011-11-01

    Title: c=c(1+1=2) The light speed 1+1=2. So we count the number by step by step for one point. When we count the number by one point, we use the number written on the paper. This means this is not number, but the graph and line. The light speed is the truth in physics. I can prove it by number. 10%=0.1 As %=kg So 10kg=0.1 kg=1/10 x 1/10 kg=1/100 And 100%=1 So kg=100%/100 kg=% So 1kg=1%=1/100 E=mc^2 So cx kgx m^2/sec^2= 1kgx cx m^2/sec^2 cx 1/100x m^2/sec^2= 1/100x cx m^2/sec^2 So c/100=c/100 So c=c And c is the truth never changed. Title: By faith, no blackhole As to be, we glory to God and that is basic theology for christian. And I want to say that BE means just thinking. There is no clue of nature and no proposition to prove it. I just believe by feeling and emotion. I trust that it can be the physic really. There are only human beings and there is no idol that is different existence from human beings, that is true to be. So the nature we see is zero and we, human beings make the zero nature as from no start and no ending. No alpha and omega mean we are idol and that there is no blackhole. Blackhole means the block is existing in the nothing(as we are no alpha and no omega). So the block cannot be existence. So if there is blackhole, then there must be the wall to block me and never walk again. The big bang and evolution mean they are no alpha and no omega and existing by themselves. So they could be existence, but big bang and evolution are just logical fact to be. We need faith as God give us the direction into our spirit.

  18. The Dropping of Atomic Bombs on Japan

    Science.gov (United States)

    Holmes, Thomas

    2005-01-01

    In an age when international terrorism poses a threat to peace and stability, the use of not only nuclear, but also biological and chemical weapons are important topics for classroom discussion. In this article, the author explores four approaches to teaching this topic. Examining a controversial topic involves the evaluation of values, the use of…

  19. Sociological and socio-psycho-historical problems of A-bomb exposed twin

    International Nuclear Information System (INIS)

    The atomic bombing of Hiroshima brought many casualities on human society, and collapsed human communities. The purpose of this study is to make mainly on pairs of monozygotic twins one of whom was exposed and the other was not, or both of whom were exposed, a general socio-psycho-historical investigations through a twin control study to find whether the bombing, which can be considered to cause major environmental changes, has had any psychological effects on the individuals. Due to the limited sample of atomic bomb exposed twins, in numbers available for study, it is necessary to have an understanding for their condions of the living and identity they have developed from the numerous mental stress they suffered, and rapid socio-cultural changes they experienced, including for changes in life from birth until the atomic bombing and aftermath of the disaster. As the result of this study, by depth interview, projective psychological research and research on socio-psycho-history of exposed twin and the nonexposed before the A-bomb and aftermath of disaster, the following were obtained: a) Although at the age of four and eight they exposed, they still keep it in clear memory of the damage and suffering in the minds. b) The damage and suffereng of the family who belonged were relatively small, the effects of their psychological sufferings continued even after these thirtyseven years. c) In the aftermath of the A-bomb disaster, the psychological bond showed strengthen through crises and following social distress. d) During the long period since the bombing, those who did not experienced A-bombing, have shown high degree of support and co-operation on their familial and social role to their counterpart. e) Even though their social or medical effects of A-bombing are relatively limited, if their spouse or close relative suffer psychological stress caused by A-bomb, they too suffer from their similar experiences. (J.P.N.)

  20. Heisenberg's war. The secret history of the German bomb

    International Nuclear Information System (INIS)

    The history of Second World War Germany's 'Uranium Project', which often is referred to as the 'myth of the German atomic bomb', has been attracting the mind's of secret service men, futurologists, historians and journalists since after the end of the war it has become possible to lift the veil of secrecy. Powers book adds another one to the many investigations published since them. His approach to the piece of history starts with Heisenberg's visit to the U.S.A. in summer 1939, describes the plans of the German Heereswaffenamt pursued with the Uranium Project, and their counterpart on the side of the Allied Forces where German scientists, as immigrants in England and in the U.S.A., were doing their best to launch research for the development of an atomic bomb. The end of this 'competition' is marked by the internment of the ten German scientists and bomb specialists in Fall Hall. The leading story of the book centers on the small group of scientists around Heisenberg, who cleverly 'torpedoed' the development of the German atomic bomb in the years from 1939 until 1944. (HP)

  1. Atoms

    Institute of Scientific and Technical Information of China (English)

    刘洪毓

    2007-01-01

    Atoms(原子)are all around us.They are something like the bricks (砖块)of which everything is made. The size of an atom is very,very small.In just one grain of salt are held millions of atoms. Atoms are very important.The way one object acts depends on what

  2. Human body projectiles implantation in victims of suicide bombings and implications for health and emergency care providers: the 7/7 experience

    OpenAIRE

    Patel, HDL; Dryden, S; Gupta, A; Stewart, N.

    2012-01-01

    INTRODUCTION On 7 July 2005 four suicide bombings occurred on the London transport systems. In some of the injured survivors, bone fragments were embedded as biological foreign bodies. The aim of this study was to revisit those individuals who had sustained human projectile implantation injuries as a result of the bomb blasts at all scenes, review the process of body parts mapping and DNA identification at the scene, detail the management of such injuries and highlight the protocols that have...

  3. Bomb pulse biology

    Energy Technology Data Exchange (ETDEWEB)

    Falso, Miranda J. Sarachine [Center for Accelerator Mass Spectrometry, Mail Stop L-397, Lawrence Livermore National Laboratory, P.O. Box 808, Livermore, CA 94551 (United States); Buchholz, Bruce A., E-mail: buchholz2@llnl.gov [Center for Accelerator Mass Spectrometry, Mail Stop L-397, Lawrence Livermore National Laboratory, P.O. Box 808, Livermore, CA 94551 (United States)

    2013-01-15

    The past decade has seen an explosion in use of the {sup 14}C bomb pulse to do fundamental cell biology. Studies in the 1960s used decay counting to measure tissue turnover when the atmospheric {sup 14}C/C concentration was changing rapidly. Today bulk tissue measurements are of marginal interest since most of the carbon in the tissue resides in proteins, lipids and carbohydrates that turn over rapidly. Specific cell types with specialized functions are the focus of cell turnover investigations. Tissue samples need to be fresh or frozen. Fixed or preserved samples contain petroleum-derived carbon that has not been successfully removed. Cell or nuclear surface markers are used to sort specific cell types, typically by fluorescence-activated cell sorting (FACS). Specific biomolecules need to be isolated with high purity and accelerator mass spectrometry (AMS) measurements must accommodate samples that generally contain less than 40 {mu}g of carbon. Furthermore, all separations must not add carbon to the sample. Independent means such as UV absorbance must be used to confirm molecule purity. Approaches for separating specific proteins and DNA and combating contamination of undesired molecules are described.

  4. A report from the 2013 international symposium: the evaluation of the effects of low-dose radiation exposure in the life span study of atomic bomb survivors and other similar studies.

    Science.gov (United States)

    Grant, E J; Ozasa, K; Ban, N; de González, A Berrington; Cologne, J; Cullings, H M; Doi, K; Furukawa, K; Imaoka, T; Kodama, K; Nakamura, N; Niwa, O; Preston, D L; Rajaraman, P; Sadakane, A; Saigusa, S; Sakata, R; Sobue, T; Sugiyama, H; Ullrich, R; Wakeford, R; Yasumura, S; Milder, C M; Shore, R E

    2015-05-01

    The RERF International Low-Dose Symposium was held on 5-6 December 2013 at the RERF campus in Hiroshima, Japan, to discuss the issues facing the Life Span Study (LSS) and other low-dose studies. Topics included the current status of low-dose risk detection, strategies for low-dose epidemiological and statistical research, methods to improve communication between epidemiologists and biologists, and the current status of radiological studies and tools. Key points made by the participants included the necessity of pooling materials over multiple studies to gain greater insight where data from single studies are insufficient; generating models that reflect epidemiological, statistical, and biological principles simultaneously; understanding confounders and effect modifiers in the current data; and taking into consideration less studied factors such as the impact of dose rate. It is the hope of all participants that this symposium be used as a trigger for further studies, especially those using pooled data, in order to reach a greater understanding of the health effects of low-dose radiation. PMID:25811153

  5. Experimental derivation of relative biological effectiveness of A-bomb neutrons in Hiroshima and Nagasaki and implications for risk assessment.

    Science.gov (United States)

    Sasaki, M S; Nomura, T; Ejima, Y; Utsumi, H; Endo, S; Saito, I; Itoh, T; Hoshi, M

    2008-07-01

    Epidemiological data on the health effects of A-bomb radiation in Hiroshima and Nagasaki provide the framework for setting limits for radiation risk and radiological protection. However, uncertainty remains in the equivalent dose, because it is generally believed that direct derivation of the relative biological effectiveness (RBE) of neutrons from the epidemiological data on the survivors is difficult. To solve this problem, an alternative approach has been taken. The RBE of polyenergetic neutrons was determined for chromosome aberration formation in human lymphocytes irradiated in vitro, compared with published data for tumor induction in experimental animals, and validated using epidemiological data from A-bomb survivors. The RBE of fission neutrons was dependent on dose but was independent of the energy spectrum. The same RBE regimen was observed for lymphocyte chromosome aberrations and tumors in mice and rats. Used as a weighting factor for A-bomb survivors, this RBE system was superior in eliminating the city difference in chromosome aberration frequencies and cancer mortality. The revision of the equivalent dose of A-bomb radiation using DS02 weighted by this RBE system reduces the cancer risk by a factor of 0.7 compared with the current estimates using DS86, with neutrons weighted by a constant RBE of 10. PMID:18582156

  6. Physicists and the 1945 Decision to Drop the Bomb

    CERN Document Server

    Byers, N

    2002-01-01

    In 1943 fear that the German war machine might use atomic bombs was abating and among physicists another fear was taking its place - that of a postwar nuclear arms race with worldwide proliferation of nuclear weapons. Manhattan Project scientists and engineers began to discuss uses of nuclear energy in the postwar world. Niels Bohr, Leo Szilard, James A. Franck and others launched a concerted effort to lay groundwork for international control of the technology. Realizing the devastation nuclear weapons could cause and that they could be made and delivered much more cheaply than conventional weapons of the same power, they tried to persuade policy makers to take into account long range consequences of using atomic bombs and not base their decisions on short range military expediency alone. They met with little success. The scientists' main message, unheeded then and very relevant now, is that worldwide international agreements are needed to provide for inspection and control of nuclear weapons technology. Thei...

  7. Physicists and the 1945 Decision to Drop the Bomb

    OpenAIRE

    Byers, Nina

    2002-01-01

    In 1943 fear that the German war machine might use atomic bombs was abating and among physicists another fear was taking its place - that of a postwar nuclear arms race with worldwide proliferation of nuclear weapons. Manhattan Project scientists and engineers began to discuss uses of nuclear energy in the postwar world. Niels Bohr, Leo Szilard, James A. Franck and others launched a concerted effort to lay groundwork for international control of the technology. Realizing the devastation nucle...

  8. The night of the physicists. Heisenberg, Hahn, Weizsaecker, and the German bomb; Die Nacht der Physiker. Heisenberg, Hahn, Weizsaecker und die deutsche Bombe

    Energy Technology Data Exchange (ETDEWEB)

    Schirach, Richard von

    2014-07-01

    Finally the German atomic physicists around Heisenberg, von Weizsaecker, and Hahn worked on their ''uranium machine'' in a Swabian beer-cellar - and took themselves for the world elite of nuclear research. In imprisonment they heared from the dropping of the Hiroshima bomb - a shock. Richard von Schirach shows the hindered ''fathers of the German atomic bomb'' in close-up, their eagerness, their hybris, their true importance, and their attempts to give after the war a new interpretation of their own role. A book, which raises in the sense of Duerrenmatt the question for the responsibility of science.

  9. A Study on the Path to Achieve Big Science Projects:Case Studies from Atomic Bomb Manufacturing Project and Manned Space Project%大科学工程的实现路径研究--基于原子弹制造工程和载人航天工程的案例剖析

    Institute of Scientific and Technical Information of China (English)

    聂继凯; 危怀安

    2015-01-01

    基于原子弹制造工程和载人航天工程的案例剖析发现,原子弹制造工程在实现过程中形成了一条计划型实现路径,载人航天工程则遵循了一条自发型实现路径。两种大科学工程的实现路径在源起、决策和实施过程中都存在明显差异。分析了大科学工程与国家科技重大专项在选择、支撑与修正的实现路径的情况,及在实现路径中充分发挥政府多角色集成效能和激发协同创新机能。%Case studies from atomic bomb manufacturing project and manned space project, the results showed that, a plan achievement path formulated in the atomic bomb manufacturing project, while a spontaneity achieve-ment path followed in the manned space project. There are significant differences in the origins, decision-making and implementation process between the two paths. This offers today's big science projects and national science and technology major projects lots of important inspiration and valuable experience at selecting, supporting and correcting achievement path, exerting government's multi-role integration efficiency and stimulating synergy innova-tion function in the achievement path.

  10. Motherhood among Incest Survivors.

    Science.gov (United States)

    Cohen, Tamar

    1995-01-01

    Mothers (n=26) who were incest survivors were compared with 28 mothers with no such history for 7 areas of parenting skills: role-image, objectivity, expectations, rapport, communication, limit-setting, and role-support. Significant differences were found on all seven scales, characterized by a tendency for the incest survivors to be less skillful…

  11. Public-private partnership from theory to practice: Walgreens and the Boston Public Health Commission supporting each other before and after the Boston bombings.

    Science.gov (United States)

    Martin, Atyia; Williams, Jim

    2014-01-01

    This paper presents an overview of the public health and medical services continuity of operations, response and recovery efforts in the aftermath of the Boston bombings. Countless public and private organisations and agencies came together to support the community and the survivors. The efforts of these organisations define what it means to be Boston Strong. PMID:24578022

  12. Pure Nuclear Fusion Bomb Propulsion

    OpenAIRE

    Winterberg, F.

    2008-01-01

    Recent progress towards the non-fission ignition of thermonuclear micro-explosions raises the prospect for a revival of the nuclear bomb propulsion idea, both for the fast transport of large payloads within the solar system and the launch into earth orbit without the release of fission products into the atmosphere. To reach this goal three areas of research are of importance: 1)Compact thermonuclear ignition drivers. 2)Fast ignition and deuterium burn. 3)Space-craft architecture involving mag...

  13. Genius in the shadows a biography of Leo Szilard, the man behind the bomb

    CERN Document Server

    Lanouette, William

    2013-01-01

    Well-known names such as Albert Einstein, Enrico Fermi, J. Robert Oppenheimer, and Edward Teller are usually those that surround the creation of the atom bomb. One name that is rarely mentioned is Leo Szilard, known in scientific circles as "father of the atom bomb." The man who first developed the idea of harnessing energy from nuclear chain reactions, he is curiously buried with barely a trace in the history of this well-known and controversial topic.Born in Hungary and educated in Berlin, he escaped Hitler's Germany in 1933 and that first year developed his concept of nucle

  14. Modelling vapour transport in Surtseyan bombs

    Science.gov (United States)

    McGuinness, Mark J.; Greenbank, Emma; Schipper, C. Ian

    2016-05-01

    We address questions that arise if a slurry containing liquid water is enclosed in a ball of hot viscous vesicular magma ejected as a bomb in the context of a Surtseyan eruption. We derive a mathematical model for transient changes in temperature and pressure due to flashing of liquid water to vapour inside the bomb. The magnitude of the transient pressure changes that are typically generated are calculated together with their dependence on material properties. A single criterion to determine whether the bomb will fragment as a result of the pressure changes is derived. Timescales for ejection of water vapour from a bomb that remains intact are also revealed.

  15. The hypothesis of radiation-accelerated aging and the mortality of Japanese A-bomb victims

    International Nuclear Information System (INIS)

    The hypothesis that ionizing radiation accelerates aging is extremely difficult to investigate in man except at the level of mortality. Among the 82000 Japanese A-bomb survivors being followed for mortality, there were 14400 deaths from non-neoplastic diseases from October 1950 to September 1974, and this experience has been analysed for evidence of a non-specific mortality differential associated with radiation dose (kerma). Cause of death has been classified as follows: neoplastic diseases individually and in various groupings, tuberculosis, cerebrovascular diseases, cardiovascular diseases other than cerebrovascular, diseases of blood and blood-forming organs, diseases of the digestive system, all other non-neoplastic diseases, and all non-neoplastic diseases. Although there is clear evidence of a radiation effect for many forms of cancer, mortality from other diseases contains little suggestion of a relationship to radiation dose. A superficial association between mortality from diseases of blood and blood-forming organs and radiation rests entirely on the carcinogenic effect of radiation, especially the leukaemogenic effect. Deaths from digestive diseases seem related to radiation dose but only in the 1971-74 period and among the Hiroshima survivors; the excess is small but occurred in all age groups. Thus far the mortality experience of the Japanese A-bomb survivors suggests that the life-shortening effect of whole-body human exposure to ionizing radiation derives from its carcinogenic effect, not from any acceleration of the aging process

  16. Pain in cancer survivors.

    Science.gov (United States)

    Brown, Matthew Rd; Ramirez, Juan D; Farquhar-Smith, Paul

    2014-11-01

    Cancer and its treatment exert a heavy psychological and physical toll. Of the myriad symptoms which result, pain is common, encountered in between 30% and 60% of cancer survivors. Pain in cancer survivors is a major and growing problem, impeding the recovery and rehabilitation of patients who have beaten cancer and negatively impacting on cancer patients' quality of life, work prospects and mental health. Persistent pain in cancer survivors remains challenging to treat successfully. Pain can arise both due to the underlying disease and the various treatments the patient has been subjected to. Chemotherapy causes painful chemotherapy-induced peripheral neuropathy (CIPN), radiotherapy can produce late effect radiation toxicity and surgery may lead to the development of persistent post-surgical pain syndromes. This review explores a selection of the common causes of persistent pain in cancer survivors, detailing our current understanding of the pathophysiology and outlining both the clinical manifestations of individual pain states and the treatment options available. PMID:26516548

  17. Radiative characteristics of depleted uranium bomb and it is protection

    International Nuclear Information System (INIS)

    Based on the developing process of depleted uranium bombs described in the first part, the radiative characteristics and mechanism of depleted uranium bombs are analyzed emphatically. The deeper discussion on protection of depleted uranium bombs is proceeded

  18. Pure Nuclear Fusion Bomb Propulsion

    CERN Document Server

    Winterberg, F

    2008-01-01

    Recent progress towards the non-fission ignition of thermonuclear micro-explosions raises the prospect for a revival of the nuclear bomb propulsion idea, both for the fast transport of large payloads within the solar system and the launch into earth orbit without the release of fission products into the atmosphere. To reach this goal three areas of research are of importance: 1)Compact thermonuclear ignition drivers. 2)Fast ignition and deuterium burn. 3)Space-craft architecture involving magnetic insulation and GeV electrostatic potentials

  19. Who are the cancer survivors?

    DEFF Research Database (Denmark)

    Hovaldt, Hanna Birkbak; Suppli, N P; Olsen, M H;

    2015-01-01

    Background: No nationwide studies on social position and prevalence of comorbidity among cancer survivors exist. Methods: We performed a nationwide prevalence study defining persons diagnosed with cancer 1943-2010 and alive on the census date 1 January 2011 as cancer survivors. Comorbidity...... was compared by social position with the non-cancer population. Results: Cancer survivors composed 4% of the Danish population. Somatic comorbidity was more likely among survivors (OR 1.59, 95% CI 1.57-1.60) and associated with higher age, male sex, short education, and living alone among survivors....... Conclusions: Among cancer survivors, comorbidity is common and highly associated with social position....

  20. Musculoskeletal problems in stroke survivors.

    Science.gov (United States)

    Kendall, Richard

    2010-01-01

    Musculoskeletal problems in stoke survivors are common reasons for disability and pain. Shoulder pain is present in 24% of stroke survivors among all complications, second only to depression in 26%. Diagnosis and treatment of the various shoulder pain etiologies can significantly improve quality of life in these patients. This article reviews the common etiologies and treatments of shoulder and hip pain in stroke survivors.

  1. UV spectra, bombs, and the solar atmosphere

    CERN Document Server

    Judge, Philip G

    2015-01-01

    A recent analysis of UV data from the Interface Region Imaging Spectrograph {\\em IRIS} reports plasma "bombs" with temperatures near \\hot{} within the solar photosphere. This is a curious result, firstly because most bomb plasma pressures $p$ (the largest reported case exceeds $10^3$ dyn~cm$^{-2}$) fall well below photospheric pressures ($> 7\\times10^3$), and secondly, UV radiation cannot easily escape from the photosphere. In the present paper the {\\em IRIS} data is independently analyzed. I find that the bombs arise from plasma originally at pressures between $\\lta80$ and 800 dyne~cm$^{-2}$ before explosion, i.e. between $\\lta850$ and 550 km above $\\tau_{500}=1$. This places the phenomenon's origin in the low-mid chromosphere or above. I suggest that bomb spectra are more compatible with Alfv\\'enic turbulence than with bi-directional reconnection jets.

  2. Convictions Beyond the Bomb: Interplays Between Violence, Religion and Development in Sri Lanka (abstract

    Directory of Open Access Journals (Sweden)

    Indika Bulankulame

    2013-02-01

    Full Text Available Prior to the conclusion of 30 years of civil war, many ordinary Sri Lankans were caught in bombings intended to disrupt daily life. This occurred not only in the war zone, but also in urban areas, primarily the capital of Colombo. While many lost their lives, others survived – scarred, disabled and traumatised. This chapter explores the meaning of ‘survival’ as experienced in newly-formed role of ‘bomb victim’. In doing so, this chapter questions the capacity of survivors to be productive as breadwinners and/or deal with the severe economic dislocations resulting from the drastic changes in their lives’ trajectories. Overall, the chapter finds that the loss of income and inability to fully participate in the market economy isolating the survivors from the main discourses of development, and purported opportunities offered therein. The end of hostilities has marked a clear drive to develop Sri Lanka, and in this important post-war stage, it is important to note the various ways in which religion is used to address survival needs. This chapter thus highlights the dynamic interplay between religion, political violence and development. In doing so, the chapter examines religious responses to (neo liberal, market-driven globalisation, the experience of terror and violence, and the interaction thereof.

  3. Genetic effect of A-bomb radiation- Analysis of minisatellite regions detected by DNA fingerprint probe

    Energy Technology Data Exchange (ETDEWEB)

    Kodaira, Mieko [Radiation Effects Research Foundation, Hiroshima (Japan)

    1999-06-01

    In author's laboratory, screening of mutation in germ cells of A-bomb survivors is under investigation with use of 8 single-locus minisatellite probes and no increase in mutation rate has been detected hitherto. This paper reported results of screening on the minisatellite region, which consisting of short repeated base sequence, using a DNA fingerprint probe for 33.15 core sequence. Subjects were 50 A-bomb survivor families exposed to mean dose of 1.9 Sv (exposed group) or 0 Gy (control), having 64 or 60 children, respectively. DNA was extracted from their B cells established by EB virus and subjected to agarose-gel electrophoresis followed by southern blotting with some improvements for fingerprinting. On the fingerprints, numbers of the band detected in regions of >3.5 kb were 1080 in children of the exposed group (16.9/child) and 1024 (17.1) in the control group, indicating no detectable effect of exposure on the germ cell mutation rate in the region.(K.H.)

  4. Bombs, flyin' high. In-flight dynamics of volcanic bombs from Strombolian to Vulcanian eruptions.

    Science.gov (United States)

    Taddeucci, Jacopo; Alatorre, Miguel; Cruz Vázquez, Omar; Del Bello, Elisabetta; Ricci, Tullio; Scarlato, Piergiorgio; Palladino, Danilo

    2016-04-01

    Bomb-sized (larger than 64 mm) pyroclasts are a common product of explosive eruptions and a considerable source of hazard, both from directly impacting on people and properties and from wildfires associated with their landing in vegetated areas. The dispersal of bombs is mostly modeled as purely ballistic trajectories controlled by gravity and drag forces associated with still air, and only recently other effects, such as the influence of eruption dynamics, the gas expansion, and in-flight collisions, are starting to be quantified both numerically and observationally. By using high-speed imaging of explosive volcanic eruptions here we attempt to calculate the drag coefficient of free-flying volcanic bombs during an eruption and at the same time we document a wide range of in-flight processes affecting bomb trajectories and introducing deviations from purely ballistic emplacement. High-speed (500 frames per second) videos of explosions at Stromboli and Etna (Italy), Fuego (Gatemala), Sakurajima (Japan), Yasur (Vanuatu), and Batu Tara (Indonesia) volcanoes provide a large assortment of free-flying bombs spanning Strombolian to Vulcanian source eruptions, basaltic to andesitic composition, centimeters to meters in size, and 10 to 300 m/s in fly velocity. By tracking the bombs during their flying trajectories we were able to: 1) measure their size, shape, and vertical component of velocity and related changes over time; and 2) measure the different interactions with the atmosphere and with other bombs. Quantitatively, these data allow us to provide the first direct measurement of the aerodynamic behavior and drag coefficient of volcanic bombs while settling, also including the effect of bomb rotation and changes in bomb shape and frontal section. We also show how our observations have the potential to parameterize a number of previously hypothesized and /or described but yet unquantified processes, including in-flight rotation, deformation, fragmentation, agglutination

  5. Bonebrake Theological Seminary - Most Secret A-Bomb Project Site

    Science.gov (United States)

    Sopka, Katherine R.; Sopka, Elisabeth M.

    2004-05-01

    In late 1943, a small number of nuclear scientists was urgently assembled in Dayton, Ohio by the U.S. Army Manhattan District Engineers and Monsanto Chemical Company Research Division to set up a top secret research project essential to counteract the German atomic bomb threat. The site chosen was an old stone building built in 1879 by the United Brethren Church in a residential area known locally as the Bonebrake Seminary. Centered on a sizeable open plot, the austere three story building was surrounded by a tall cyclone fence with a narrow gate and a minimal guard post - nothing revealed the site's intense research activity then or even in the post-WWII Cold War period. Bonebrake scientists would produce the highly radioactive polonium sources for the plutonium (Pu-239) bomb igniter used in August over Nagasaki just before the end of WWII against Japan. The existence of Bonebrake and its research/production work remained classified top secret throughout the Cold War. Only in recent times can any reference be found even to the existence of this project (unlike , for example, Los Alamos or Oak Ridge) and few, if any details, have ever been published. The primary source of information for this paper is Dr. John J. Sopka who was recruited from Princeton University by the Manhattan District in 1943 as physicist for this project.

  6. Atomic arias

    Science.gov (United States)

    Crease, Robert P.

    2009-01-01

    The American composer John Adams uses opera to dramatize controversial current events. His 1987 work Nixon in China was about the landmark meeting in 1972 between US President Richard Nixon and Chairman Mao Zedong of China; The Death of Klinghoffer (1991) was a musical re-enactment of an incident in 1985 when Palestinian terrorists kidnapped and murdered a wheelchair-bound Jewish tourist on a cruise ship. Adams's latest opera, Doctor Atomic, is also tied to a controversial event: the first atomic-bomb test in Alamogordo, New Mexico, on 16 June 1945. The opera premièred in San Francisco in 2005, had a highly publicized debut at the Metropolitan Opera in New York in 2008, and will have another debut on 25 February - with essentially the same cast - at the English National Opera in London.

  7. AFSC/REFM: Bomb-produced age validation study

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Fish age validation with bomb-produced radiocarbon (14C) requires a known-age Delta14C reference chronology spanning the era of a marine increase in bomb-produced...

  8. The contaminated Western Hero and other madness during the Atomic Age

    International Nuclear Information System (INIS)

    The book on mad activities during the Atomic Age includes the following topics: The second most hazardous invention in all time; the red bomb; the story on the tactic nuclear war; the contaminated Western hero or how the bomb came to Alaska; swords into plowshares; the apocalypse machine; flying reactors; how safe is safe?; atomic Australia; nuclear medicine on wrong ways; broken arrows.

  9. Rehabilitation interventions for cancer survivors

    DEFF Research Database (Denmark)

    Hansen, Helle Ploug; Tjørnhøj-Thomsen, Tine; Johansen, Christoffer

    2011-01-01

    The present study examines the influence of three contextual parameteres in rehabilitation courses for cancer survivors in Denmark. It is based on ethonographic fieldwork.......The present study examines the influence of three contextual parameteres in rehabilitation courses for cancer survivors in Denmark. It is based on ethonographic fieldwork....

  10. The Radium Terrors. Science Fiction and Radioactivity before the Bomb.

    Science.gov (United States)

    Candela, Andrea

    2015-01-01

    At the beginning of the 20th century the collective imagination was fascinated and terrified by the discovery of radium. A scientific imagery sprang up around radioactivity and was disseminated by public lectures and newspaper articles discussing the ambiguous power of this strange substance. It was claimed that radium could be used to treat cholera, typhus and tuberculosis, but at the same time there were warnings that it could be used for military purposes. The media and the scientists themselves employed a rich vocabulary influenced by religion, alchemy and magic. The ambivalent power of radioactive elements exerted a great influence on science fiction novelists. This paper will examine some significant works published in Europe, America and Russia during the first decades of the 20th century and their role in the creation of the complex imagery of radioactivity that seized the public imagination long before the invention of the atomic bomb.

  11. Terror, tortur og den tikkende bombe

    DEFF Research Database (Denmark)

    Dige, Morten

    2012-01-01

    a catastrophe? I criticize arguments based on ticking bomb scenarios in two steps. First, I show that exceptional resort to torture will not be possible in the situations where it is most needed. Second, I state several pragmatic as well as principled objections against a state sanctioned or tolerated practice...

  12. The 'secureplan' bomb utility: A PC-based analytic tool for bomb defense

    International Nuclear Information System (INIS)

    This paper illustrates a recently developed, PC-based software system for simulating the effects of an infinite variety of hypothetical bomb blasts on structures and personnel in the immediate vicinity of such blasts. The system incorporates two basic rectangular geometries in which blast assessments can be made - an external configuration (highly vented) and an internal configuration (vented and unvented). A variety of explosives can be used - each is translated to an equivalent TNT weight. Provisions in the program account for bomb cases (person, satchel, case and vehicle), mixes of explosives and shrapnel aggregates and detonation altitudes. The software permits architects, engineers, security personnel and facility managers, without specific knowledge of explosives, to incorporate realistic construction hardening, screening programs, barriers and stand-off provisions in the design and/or operation of diverse facilities. System outputs - generally represented as peak incident or reflected overpressure or impulses - are both graphic and analytic and integrate damage threshold data for common construction materials including window glazing. The effects of bomb blasts on humans is estimated in terms of temporary and permanent hearing damage, lung damage (lethality) and whole body translation injury. The software system has been used in the field in providing bomb defense services to a number of commercial clients since July of 1986. In addition to the design of siting, screening and hardening components of bomb defense programs, the software has proven very useful in post-incident analysis and repair scenarios and as a teaching tool for bomb defense training

  13. Pros and cons on ''Hitlers' bomb''. Studies on nuclear research in Germany; Fuer und Wider ''Hitlers Bombe''. Studien zur Atomforschung in Deutschland

    Energy Technology Data Exchange (ETDEWEB)

    Karlsch, R.; Petermann, H. (eds.)

    2007-07-01

    This book reveals a sensation: Under supervision of the SS German scientists tested 1944/45 nuclear bombs on Ruegen and in Thuringia. During this period several hundred prisoners of war and prisoners died. Besides proofs for nuclear weapon testing the author also found a draft for a patent on plutonium bombs and discovered the first functioning German atom reactor in the environs of Berlin. The succeeding book titled above enlarges the spectra of contributions from Saenger PLan to attack New York, researches on minimization of critical mass, the attempt to calculate TNT-equivalence as the presentation of important acteurs occuring during the researches. (GL)

  14. The Impact of the Atomic Bomb on Education

    Science.gov (United States)

    Gelbond, Florence

    1974-01-01

    The teachers of social studies must take on the responsibilities of generating a world consciouness, of continuing the search for a world order of government which are not currently transmitted through textbooks. (Author/RM)

  15. Recurrent Education: "Apple Pie" ...or..."Atomic Bomb"?

    Science.gov (United States)

    Day, William L.

    The author conceptualizes recurrent education as organized, structured, institutionally sponsored learning activities with intentional outcomes, which are distributed over the life span of the individual in a recurring way. Some problems to which recurrent education proposes solutions include: alienation at the inter-generational level,…

  16. Obituary Professor Victor Weisskopf - atom-bomb and CERN physicist

    CERN Multimedia

    Dalyell, T

    2002-01-01

    The rise of Nazism brought horror, humiliation, death and torture to so many free-thinking people - Jews, and other minorities. There were some lucky ones, like the Weisskopf family, who were able to escape. Victor Weisskopf was born and brought up in Austria in the spirit of German culture and said that he considered his transfer from Europe to the USA an invaluable source of intellectual enrichment (2 pages).

  17. A-bomb radiation and evidence of late effects other than cancer.

    Science.gov (United States)

    Stewart, A M; Kneale, G W

    1990-06-01

    Cancer risk coefficients for ionizing radiation are currently based on the assumption that, after the bombing of Hiroshima and Nagasaki, there were no late effects of early selection (survival of the fittest) or acute marrow damage. These negative findings were the result of applying a linear model of relative risk to the deaths of 5-y survivors. By applying a linear-quadratic model to these deaths (i.e., a model with more than one degree of freedom), we have obtained evidence of longstanding competition between selection effects of the early deaths and other radiation effects, and also evidence that late effects of radiation include marrow damage as well as cancer. Consequently, the present method of risk estimation--by linear extrapolation of high dose effects--should no longer be used for estimating the cancer effects of occupational exposures or background radiation. PMID:2345104

  18. Cancer survivors' experience of time

    DEFF Research Database (Denmark)

    Rasmussen, Dorte M.; Elverdam, Beth

    2007-01-01

    time and life; (2) awareness of time increases, time is verbalized and reflected; and (3) the informants appropriate time. A diagnosis of cancer, even for a survivor, means a confrontation with death. It means a disruption of continuous clock and calendar time. Survivors appropriate time......AIM: This paper reports a study to explore how cancer survivors talk about, experience and manage time in everyday life. BACKGROUND: There is an increasing interest in specific physical and psychosocial aspects of life after cancer diagnosis and treatment, but hardly any research follows cancer...... survivors over time to explore how perceptions and experiences change. METHODS: An exploratory study was carried out in 2002-2004 with a purposive sample of adults who had experienced various forms of cancer. Data collection included 9 weeks of participant observation at a Cancer Rehabilitation Centre...

  19. The contaminated Western Hero and other madness during the Atomic Age; Der verstrahlte Westernheld und anderer Irrsinn aus dem Atomzeitalter

    Energy Technology Data Exchange (ETDEWEB)

    Herzog, Rudolph

    2012-11-01

    The book on mad activities during the Atomic Age includes the following topics: The second most hazardous invention in all time; the red bomb; the story on the tactic nuclear war; the contaminated Western hero or how the bomb came to Alaska; swords into plowshares; the apocalypse machine; flying reactors; how safe is safe?; atomic Australia; nuclear medicine on wrong ways; broken arrows.

  20. Methodological extensions of meta-analysis with excess relative risk estimates. Application to risk of second malignant neoplasms among childhood cancer survivors treated with radiotherapy

    International Nuclear Information System (INIS)

    Although radiotherapy is recognized as an established risk factor for second malignant neoplasms (SMNs), the dose response of SMNs following radiotherapy has not been well characterized. In our previous meta-analysis of the risks of SMNs occurring among children who have received radiotherapy, the small number of eligible studies precluded a detailed evaluation. Therefore, to increase the number of eligible studies, we developed a method of calculating excess relative risk (ERR) per Gy estimates from studies for which the relative risk estimates for several dose categories were available. Comparing the calculated ERR with that described in several original papers validated the proposed method. This enabled us to increase the number of studies, which we used to conduct a meta-analysis. The overall ERR per Gy estimate of radiotherapy over 26 relevant studies was 0.60 (95% CI: 0.30-1.20), which is smaller than the corresponding estimate for atomic bomb survivors exposed to radiation as young children (1.7; 95% CI: 1.1-2.5). A significant decrease in ERR per Gy with increase in age at exposure (0.85 times per annual increase) was observed in the meta-regression. Heterogeneity was suggested by Cochran's Q statistic (P < 0.001), which may be partly accounted for by age at exposure. (author)

  1. Australia's atomic conspiracy theory

    International Nuclear Information System (INIS)

    The author questions claims by the Newcastle University historian Wayne Reynolds in his book 'Australia's Bid for the Bomb', that the impetus behind the Snowy Mountains Scheme was to provide a secure source of power for the enrichment of uranium and production of heavy water so that Australia could produce its own atomic bombs. Reynolds also argued that the Australian Atomic Energy Commission (AAEC) was set up so that Australia had a trained scientific workforce to produce plutonium for the bomb. While the book is well researched, Reynolds does not seem to understand the principles of basic science and engineering. After the Second World War, a manufacturing and industrial base with a skilled and trained workforce was needed so it could be converted to war or defence manufacturing when the need arose. This new manufacturing community would require electrical power to sustain it. Hydroelectricity and atomic energy could help provide these needs. Even though war was still raging, Prime Minister John Curtin looked ahead and set up a Department of Post-War Reconstruction. It was through this department that the Snowy Mountains Scheme would be established. Curtin did not live to see this. He died in 1945 but his successor, Ben Chifley, continued the vision. The author believes, an understanding of the science behind these developments and an appreciation of how how humans interact with each others when it comes to getting something they want is likely to give a more balanced view of the past

  2. Pragmatic evaluation of repercussions for radiological protection of recent revisions in Japanese A-bomb dosimetry

    International Nuclear Information System (INIS)

    The recent re-evaluation of the dose data for the Japanese A-bomb survivors shows significant differences from the doses used by UNSCEAR, BEIR and ICRP. In particular the neutron dose is now considered to be very small at both Hiroshima and Nagasaki. Detailed revision and application of the new dose estimates is an ongoing process and it may take some time for definitive risk estimates to emerge. In the interim it is considered important to review and encourage risk estimation using data other than those from Japan. Estimates are given of low-LET risks based on the data of UNSCEAR (1977) but specifically excluding the bomb data. A total cancer mortality risk figure is found which is within a factor of 2 of the value given in ICRP Publication 26, but in accord with estimates of BEIR and UNSCEAR before reduction to account for dose rate/response effects. The need to consider the revised dose estimates for Hiroshima and Nagasaki focuses attention on the paucity of data on which dose limits for high-LET radiation can be based. Here too it is necessary to concentrate effort on the best use of all available human data, however limited, such as those from radiotherapy, occupational and environmental exposures. (author)

  3. Work of the Tamm-Sakharov group on the first hydrogen bomb

    Science.gov (United States)

    Ritus, V. I.

    2014-09-01

    This review is an extended version of a report delivered at a session of the Department of Physical Sciences, the Department of Energetics, Mechanical Engineering, Mechanics, and Control Processes, and the Coordination Council on Technical Sciences of the RAS devoted to the 60th anniversary of the first hydrogen bomb test. The significant physical ideas suggested by A D Sakharov and V L Ginzburg underlying our first hydrogen bomb, RDS-6s, and numerous concrete problems and difficulties that had to be solved and overcome in designing thermonuclear weapons are presented. The understanding of the country's leaders and the Atomic Project managers of the exceptional role of fundamental science in the appearance and implementation of our scientists' concrete ideas and suggestions is emphasized.

  4. Modeling the low-LET dose-response of BCR-ABL formation: predicting stem cell numbers from A-bomb data.

    Science.gov (United States)

    Radivoyevitch, T; Hoel, D G

    1999-01-01

    Formation of the BCR-ABL chromosomal translocation t(9;22)(q34;q11) is essential to the genesis of chronic myeloid leukemia (CML). An interest in the dose-response of radiation induced CML therefore leads naturally to an interest in the dose-response of BCR-ABL formation. To predict the BCR-ABL dose-response to low-linear energy transfer (LET) ionizing radiation, three models valid over three different dose ranges are examined: the first for doses greater than 80 Gy, the second for doses less than 5 Gy and the third for doses greater than 2 Gy. The first of the models, due to Holley and Chatterjee, ignores the accidental binary eurejoining of DNA double-strand break (DSB) free ends ('eurejoining' refers to the accidental restitution of DSB free ends with their own proper mates). As a result, the model is valid only in the limit of high doses. The second model is derived directly from cytogenetic data. This model has the attractive feature that it implicitly accounts for single-track effects at low doses. The third model, based on the Sax-Markov binary eurejoining/misrejoining (SMBE) algorithm, does not account for single-track effects and is therefore limited to moderate doses greater than approximately 2 Gy. Comparing the second model to lifetime excess CML risks expected after 1 Gy, estimates of the number of hematopoietic stem cells capable of causing CML were obtained for male and female atomic bomb survivors in Hiroshima and Nagasaki. The stem cell number estimates lie in the range of 5 x 10(7)-3 x 10(8) cells. PMID:10616282

  5. The bomb black market - Inquiry about nuclear proliferation

    International Nuclear Information System (INIS)

    Nuclear weapons remain for a long time in the hands of the five big powers: USA, Soviet Union, Great Britain, France and China. Things started to change when Israel, and then India acquired the atomic bomb as well. Pakistan took up the race too but Abdul Qadeer Khan, one of the nuclear program maker of the country, took profit of the situation to set up a huge international proliferation network for the spreading of the technologies, tools and materials necessary for weapons fabrication. He offered his services not only to Iran and North Korea, but to Iraq and Libya as well and probably to some other countries. Today, the Iranian nuclear program generates both envy and fear in the Middle East. Who is going to be the next domino of the nuclear game? Egypt, Saudi Arabia, Algeria and Turkey are potential candidates. But while Pakistan sinks into crisis, the terrorists are taking interest in nukes. The author of this book has worked for more than 10 years on this dossier. He has had access to the most sensible documents and to essential testimonies. He now lifts the curtain on the secrets of nuclear proliferation. In this book, where reality sometimes surpasses fiction, he explains how the CIA finally succeeded in infiltrating the 'Khan ring' after having closed its eyes on his deals for a long time. He describes the branches of the Pakistani atomic complex and analyses with lucidity the nuclear terrorism risk

  6. 36Cl bomb peak: comparison of modeled and measured data

    Directory of Open Access Journals (Sweden)

    A. Eichler

    2009-06-01

    Full Text Available The extensive nuclear bomb testing of the fifties and sixties and the final tests in the seventies caused a strong 36Cl peak that has been observed in ice cores world-wide. The measured 36Cl deposition fluxes in eight ice cores (Dye3, Fiescherhorn, Grenzgletscher, Guliya, Huascarán, North GRIP, Inylchek (Tien Shan and Berkner Island were compared with an ECHAM5-HAM general circulation model simulation (1952–1972. We find a good agreement between the measured and the modeled 36Cl fluxes assuming that the bomb test produced global 36Cl input was ~80 kg. The model simulation indicates that the fallout of the bomb test produced 36Cl is largest in the subtropics and mid-latitudes due to the strong stratosphere-troposphere exchange. In Greenland the 36Cl bomb signal is quite large due to the relatively high precipitation rate. In Antarctica the 36Cl bomb peak is small but is visible even in the driest areas. The model suggests that the large bomb tests in the Northern Hemisphere are visible around the globe but the later (end of sixties and early seventies smaller tests in the Southern Hemisphere are much less visible in the Northern Hemisphere. The question of how rapidly and to what extent the bomb produced 36Cl is mixed between the hemispheres depends on the season of the bomb test. The model results give an estimate of the amplitude of the bomb peak around the globe.

  7. 36Cl bomb peak: comparison of modeled and measured data

    Directory of Open Access Journals (Sweden)

    A. Eichler

    2009-01-01

    Full Text Available The extensive nuclear bomb testing of the fifties and sixties and the final tests in the seventies caused a strong 36Cl peak that has been observed in ice cores world-wide. The measured 36Cl deposition fluxes in eight ice cores (Dye3, Fiescherhorn, Grenzgletscher, Guliya, Huascarán, North GRIP, Inylchek (Tien Shan and Berkner Island were compared with an ECHAM5-HAM general circulation model simulation (1952–1972. We find a good agreement between the measured and the modeled 36Cl fluxes assuming that the bomb test produced global 36Cl input was ~80 kg. The model simulation indicates that the fallout of the bomb test produced 36Cl is largest in the subtropics and mid-latitudes due to the strong stratosphere-troposphere exchange. In Greenland the 36Cl bomb signal is quite large due to the relatively high precipitation rate. In Antarctica the 36Cl bomb peak is small but is visible even in the driest areas. The model suggests that the large bomb tests in the Northern Hemisphere are visible around the globe but the later (end of sixties and early seventies smaller tests in the Southern Hemisphere are much less visible in the Northern Hemisphere. The question of how rapidly and to what extent the bomb produced 36Cl is mixed between the hemispheres depends on the season of the bomb test. The model results give an estimate of the amplitude of the bomb peak around the globe.

  8. Proceedings of 41st Research Society for the Late Effects of the A-Bomb

    International Nuclear Information System (INIS)

    This issue is the collection of study papers presented in the meeting in the title of the special review lecture concerning the late effect research, the symposium concerning the Tokai JCO criticality accident (6 presentations: radiation quality and dose assessment, treatment of highly-irradiated patients, medical preparedness, health care with its global standard for the residents, health management of public, and proposal from a view of medical care supporting A-bomb survivors) and 47 general presentations. The general presentations included 6 concerning the health care and management of the survivors, 3, hematological examinations, 2, cancer risk (lung and mammary gland), 1, blood pressure, 1, urinary occult blood, 4, thyroid diseases involving its cancer, 5, health physics studies in relation to Semipalatinsk and/or Belarus-Chernobyl, 4, experimental studies using animals, 4, cytological studies like gene mutation, 17, basic radiation biology studies such as those on gene expression, cloning (human REV1), mutation, abnormal protein expression, apoptosis, and gene therapy of hepatoma cells. (K.H.)

  9. Stroke Survivors Often Struggle with Depression

    Science.gov (United States)

    ... fullstory_160835.html Stroke Survivors Often Struggle With Depression Risk was 8 times higher for those who ... Stroke survivors face an increased risk of developing depression, a new study suggests. In the first three ...

  10. Childhood Cancer Survivor Study: An Overview

    Science.gov (United States)

    ... Cancers of Childhood Treatment Childhood Cancer Genomics Research Childhood Cancer Survivor Study: An Overview In 2016, it ... Late Effects of Treatment for Childhood Cancer .) The Childhood Cancer Survivor Study ( CCSS ), funded by the National ...

  11. Why Breast Cancer Survivors Should Exercise

    Science.gov (United States)

    ... fullstory_159781.html Why Breast Cancer Survivors Should Exercise Moderate physical activity can ease stress that impairs ... to memory problems among breast cancer survivors, but exercise can help, according to new research. "We found ...

  12. 5 CFR 850.202 - Survivor elections.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false Survivor elections. 850.202 Section 850... (CONTINUED) RETIREMENT SYSTEMS MODERNIZATION Applications for Benefits; Elections § 850.202 Survivor elections. (a) A survivor election under subsection (j) or (k) of section 8339, or under section 8416,...

  13. Internet Use and Breast Cancer Survivors

    Science.gov (United States)

    Muhamad, Mazanah; Afshari, Mojgan; Mohamed, Nor Aini

    2011-01-01

    A survey was administered to 400 breast cancer survivors at hospitals and support group meetings in Peninsular Malaysia to explore their level of Internet use and factors related to the Internet use by breast cancer survivors. Findings of this study indicated that about 22.5% of breast cancer survivors used Internet to get information about breast…

  14. Suicide bomb attack causing penetrating craniocerebral injury

    Institute of Scientific and Technical Information of China (English)

    Manzar Hussain; Muhammad Ehsan Bari

    2013-01-01

    Penetrating cerebral injuries caused by foreign bodies are rare in civilian neurosurgical trauma,although there are various reports of blast or gunshot injuries in warfare due to multiple foreign bodies like pellets and nails.In our case,a 30-year-old man presented to neurosurgery clinic with signs and symptoms of right-sided weakness after suicide bomb attack.The skull X-ray showed a single intracranial nail.Small craniotomy was done and the nail was removed with caution to avoid injury to surrounding normal brain tissue.At 6 months' follow-up his right-sided power improved to against gravity.

  15. CALCULATION OF PER PARCEL PROBABILITY FOR DUD BOMBS IN GERMANY

    Directory of Open Access Journals (Sweden)

    S. M. Tavakkoli Sabour

    2014-10-01

    Full Text Available Unexploded aerial Bombs, also known as duds or unfused bombs, of the bombardments in the past wars remain explosive for decades after the war under the earth’s surface threatening the civil activities especially if dredging works are involved. Interpretation of the aerial photos taken shortly after bombardments has been proven to be useful for finding the duds. Unfortunately, the reliability of this method is limited by some factors. The chance of finding a dud on an aerial photo depends strongly on the photography system, the size of the bomb and the landcover. On the other hand, exploded bombs are considerably better detectable on aerial photos and confidently represent the extent and density of a bombardment. Considering an empirical quota of unfused bombs, the expected number of duds can be calculated by the number of exploded bombs. This can help to have a better calculation of cost-risk ratio and to classify the areas for clearance. This article is about a method for calculation of a per parcel probability of dud bombs according to the distribution and density of exploded bombs. No similar work has been reported in this field by other authors.

  16. H-alpha features with hot onsets. I. Ellerman bombs

    CERN Document Server

    Rutten, R J

    2016-01-01

    Ellerman bombs are transient brightenings of the wings of the Balmer lines that uniquely mark reconnection in the solar photosphere. They are also bright in strong Ca II and ultraviolet lines and in ultraviolet continua, but they are not visible in the optical continuum and the Na I D and Mg I b lines. These discordant visibilities invalidate all published Ellerman bomb modeling. I argue that the assumption of Saha-Boltzmann lower-level populations is informative to estimate bomb-onset opacities for these diverse diagnostics, even and especially for H-alpha, and employ such estimates to gauge the visibilities of Ellerman bomb onsets in all of them. They constrain Ellerman bomb formation to temperatures 10,000 - 20,000 K and hydrogen densities around 10^15 cm^-3. Similar arguments likely hold for H-alpha visibility in other transient phenomena with hot and dense onsets.

  17. Site-specific dose-response relationships for cancer induction from the combined Japanese A-bomb and Hodgkin cohorts for doses relevant to radiotherapy

    Directory of Open Access Journals (Sweden)

    Sumila Marcin

    2011-07-01

    Full Text Available Abstract Background and Purpose Most information on the dose-response of radiation-induced cancer is derived from data on the A-bomb survivors. Since, for radiation protection purposes, the dose span of main interest is between zero and one Gy, the analysis of the A-bomb survivors is usually focused on this range. However, estimates of cancer risk for doses larger than one Gy are becoming more important for radiotherapy patients. Therefore in this work, emphasis is placed on doses relevant for radiotherapy with respect to radiation induced solid cancer. Materials and methods For various organs and tissues the analysis of cancer induction was extended by an attempted combination of the linear-no-threshold model from the A-bomb survivors in the low dose range and the cancer risk data of patients receiving radiotherapy for Hodgkin's disease in the high dose range. The data were fitted using organ equivalent dose (OED calculated for a group of different dose-response models including a linear model, a model including fractionation, a bell-shaped model and a plateau-dose-response relationship. Results The quality of the applied fits shows that the linear model fits best colon, cervix and skin. All other organs are best fitted by the model including fractionation indicating that the repopulation/repair ability of tissue is neither 0 nor 100% but somewhere in between. Bone and soft tissue sarcoma were fitted well by all the models. In the low dose range beyond 1 Gy sarcoma risk is negligible. For increasing dose, sarcoma risk increases rapidly and reaches a plateau at around 30 Gy. Conclusions In this work OED for various organs was calculated for a linear, a bell-shaped, a plateau and a mixture between a bell-shaped and plateau dose-response relationship for typical treatment plans of Hodgkin's disease patients. The model parameters (α and R were obtained by a fit of the dose-response relationships to these OED data and to the A-bomb survivors. For

  18. Bomb-spike dating of a mummified baboon in Ludwig Cave, Namibia

    OpenAIRE

    Hodgins Greg; Brook George A.; Marais Eugene

    2007-01-01

    In 1982 a mummified adult female baboon was discovered on a ledge in Ludwig Cave in Namibia. A toe bone was removed for dating in July 1995. AMS radiocarbon dating of bone collagen, tendon, and skin indicates a post-modern age. Application of the atomic bomb-spike calibration curve suggests death in late 1977 and an age at death of around 19 years. Baboons roost in the cave and the mummified female, along with a mummified juvenile male discovered in 2002 and three rotting corpses discovered i...

  19. Hitler's bomb: the secret story of Germans' attempts to get the nuclear weapon

    International Nuclear Information System (INIS)

    In this historical book, the author claims to have evidence concerning the development and testing of a possible 'nuclear weapon' by Nazi Germany in 1945. The 'weapon' in question is not alleged to be a standard nuclear weapon powered by nuclear fission, but something closer to either a radiological weapon (a so-called 'dirty bomb') or a hybrid-nuclear fusion weapon. Its new evidence is concerned primarily with the parts of the German nuclear energy project (an attempted clandestine scientific effort led by Germany to develop and produce atomic weapons during World War II) under Kurt Diebner, a German nuclear physicist who directed and administrated the project

  20. The 'atom-splitting' moment of synthetic biology: Nuclear physics and synthetic biology share common features

    OpenAIRE

    Valentine, Alex J; Kleinert, Aleysia; Verdier, Jerome

    2012-01-01

    Synthetic biology and nuclear physics share many commonalities in terms of public perception and funding. Synthetic biologists could learn valuable lessons from the history of the atomic bomb and nuclear power.