WorldWideScience

Sample records for atomic bomb neutrons

  1. Accounting for neutron exposure in the Japanese atomic bomb survivors.

    Science.gov (United States)

    Cullings, Harry M; Pierce, Donald A; Kellerer, Albrecht M

    2014-12-01

    The Japanese atomic bomb survivors that were directly exposed to both γ rays and neutrons have been followed by the Radiation Effects Research Foundation (RERF). The estimation of the γ-ray risks requires some adjustment for the greater biological effect of the neutrons per unit dose. Because the small neutron doses and the predominant γ-ray doses are highly correlated, the neutron relative biological effectiveness (RBE) cannot be reliably estimated from the survivors' data and information from radiobiology must be invoked. As data became available on neutron doses, RERF has used a constant neutron RBE value of 10, even though radiobiological studies indicate that the RBE values appear to have considerably larger values at low doses. The approximation RBE = 10 assumes that if the RBE is variable it takes roughly this value in the range of total dose most relevant for linear risk estimation, namely about 1 Gy. We consider some possible RBE functions to explain the correct use and the impact of a dose-dependent RBE. However, we do not advocate any particular choice or even that a variable RBE be employed. Rather we show that the assumed neutron RBE, within a wide range of choices, is far less important to the outcome of risk assessment of the RERF data than generally believed. Some of these misperceptions have been related to the consideration of variable RBE functions, and without due attention to the fact that in the case of the A-bomb survivors' data, the mixed field of neutrons and γ rays must be considered. Therefore, the RBE value of neutrons is much lower than the RBE in pure neutron fields that are used in radiobiological experiments. Thus, applying the pure neutron field RBE to the mixed-field A-bomb radiation can lead to an overestimation of the actual neutron RBE for moderate total dose levels of 1 Gy by a factor of more than four. While in a pure neutron exposure the RBE depends on the neutron dose, in the mixed field it depends on both components of

  2. Neutron and gamma ray calculation for Hiroshima-type atomic bomb

    Energy Technology Data Exchange (ETDEWEB)

    Hoshi, Masaharu; Endo, Satoru; Takada, Jun [Hiroshima Univ. (Japan). Research Inst. for Radiation Biology and Medicine; Iwatani, Kazuo; Oka, Takamitsu; Shizuma, Kiyoshi; Fujita, Shoichiro; Hasai, Hiromi

    1998-03-01

    We looked at the radiation dose of Hiroshima and Nagasaki atomic bomb again in 1986. We gave it the name of ``Dosimetry System 1986`` (DS86). We and other groups have measured the expose dose since 1986. Now, the difference between data of {sup 152}Eu and the calculation result on the basis of DS86 was found. To investigate the reason, we carried out the calculations of neutron transport and neutron absorption gamma ray for Hiroshima atomic bomb by MCNP3A and MCNP4A code. The problems caused by fast neutron {sup 32}P from sulfur in insulator of pole. To correct the difference, we investigated many models and found agreement of all data within 1 km. (S.Y.)

  3. Atomic bomb cataracts

    International Nuclear Information System (INIS)

    Shiraeda, Kanji

    1992-01-01

    Eye disturbance caused by atomic bomb radiation can be divided into three groups: direct injury immediately after exposure, eye lesions associated with radiation syndrome, and delayed disturbance. The crystalline lens of the eye is the most radiosensitive. Atomic bomb cataract has been investigated in a number of studies. The first section of this chapter discusses radiation cataract in terms of the incidence and characteristics. The second section deals with atomic bomb cataract, which can be diagnosed based on the four criteria: (1) opacity of the crystalline lens, (2) a history of proximal exposure, (3) lack of eye disease complicating cataract, and (4) non-exposure to radiation other than atomic bombing. The prevalence of cataract and severity of opacity are found to correlate with exposure doses and age at the time of exposure. Furthermore, it is found to correlate with distance from the hypocenter, the condition of shielding, epilation, and the presence or absence or degree of radiation syndrome. (N.K.)

  4. Korean atomic bomb victims.

    Science.gov (United States)

    Sasamoto, Yukuo

    2009-01-01

    After colonizing Korea, Japan invaded China, and subsequently initiated the Pacific War against the United States, Britain, and their allies. Towards the end of the war, U.S. warplanes dropped atomic bombs on Hiroshima and Nagasaki, which resulted in a large number of Koreans who lived in Hiroshima and Nagasaki suffering from the effects of the bombs. The objective of this paper is to examine the history of Korea atomic bomb victims who were caught in between the U.S., Japan, the Republic of Korea (South Korea) and the Democratic People's Republic of Korea (North Korea).

  5. Atomic bomb and leukemia

    International Nuclear Information System (INIS)

    Ichimaru, M.; Tomonaga, M.; Amenomori, T.; Matsuo, T.

    1991-01-01

    Characteristic features of the leukemia among atomic bomb survivors were studied. Dose estimates of atomic bomb radiation were based on T65D, but the new dosimetry system DS86 was used for some analyses. The ratio of a single leukemia type to all leukemias was highest for chronic myelogenous leukemia (CML) in Hiroshima, and the occurrence of CML was thought to be most characteristic to atomic bomb radiation induced leukemia. The threshold of CML occurrence in Hiroshima is likely to be between 0.5∼0.09 Gy. However, the threshold of acute leukemia appears to be nearly 1 Gy. In the distribution of acute myeloid leukemia (AML) subtypes by French-American-British classification, there was no M3 case in 1 Gy or more group, although several atypical AML cases of survivors were observed. Although aplastic anemia has not increased as a late effect of the atomic bomb radiation exposure, many atypical leukemia or other myeloproliferative diseases who had been diagnosed as aplastic anemia or its related diseases have been experienced among atomic bomb survivors. Chromosome study was conducted using colony forming cells induced by hemopoietic stem cells of peripheral blood of proximal survivors. Same chromosome aberrations were observed in colony forming cells and peripheral T-cells in several atomic bomb survivors. (author)

  6. Atomic bomb and leukemia

    Energy Technology Data Exchange (ETDEWEB)

    Ichimaru, M.; Tomonaga, M.; Amenomori, T.; Matsuo, T. (Nagasaki Univ. (Japan). School of Medicine)

    1991-12-01

    Characteristic features of the leukemia among atomic bomb survivors were studied. Dose estimates of atomic bomb radiation were based on T65D, but the new dosimetry system DS86 was used for some analyses. The ratio of a single leukemia type to all leukemias was highest for chronic myelogenous leukemia (CML) in Hiroshima, and the occurrence of CML was thought to be most characteristic to atomic bomb radiation induced leukemia. The threshold of CML occurrence in Hiroshima is likely to be between 0.5{approx}0.09 Gy. However, the threshold of acute leukemia appears to be nearly 1 Gy. In the distribution of acute myeloid leukemia (AML) subtypes by French-American-British classification, there was no M3 case in 1 Gy or more group, although several atypical AML cases of survivors were observed. Although aplastic anemia has not increased as a late effect of the atomic bomb radiation exposure, many atypical leukemia or other myeloproliferative diseases who had been diagnosed as aplastic anemia or its related diseases have been experienced among atomic bomb survivors. Chromosome study was conducted using colony forming cells induced by hemopoietic stem cells of peripheral blood of proximal survivors. Same chromosome aberrations were observed in colony forming cells and peripheral T-cells in several atomic bomb survivors. (author).

  7. Relationship of stature to gamma and neutron exposure among atomic bomb survivors aged less than 10 at the time of the bomb, Hiroshima and Nagasaki

    International Nuclear Information System (INIS)

    Ishimaru, Toranosuke; Amano, Takako; Kawamoto, Sadahisa.

    1982-10-01

    A reanalysis has been undertaken of the relationship of attained adult height of Hiroshima and Nagasaki atomic bomb survivors aged less than 10 at the time of the bomb (ATB) to radiation dose based upon new dosimetry data. The present analysis aims to examine the relationship of stature to radiation dose in terms of gamma rays and neutrons, separately. The 628 individuals were selected from Hiroshima and Nagasaki survivors, aged less than 10 ATB, whose doses were available, and whose statures were recorded at the Adult Health Study (AHS) biennial health examination during 1970-72. To ascertain the relationship of attained adult stature to gamma and neutron doses three doseresponse models were applied to the data. The analysis revealed that the attained height is a separate function of exposure to gamma rays and neutrons. The model assuming a squared term dependence on gamma rays and a linear dependence on neutrons provides a better explanation of the data. The regression coefficient associated with the squared gamma dose is -0.00000927 and the coefficient associated with neutron dose is -0.0172. The relative biological effectiveness of neutrons in relation to gamma radiation with respect to the effect for diminished development of stature is estimated as 43.1 / √Dn in kerma (Dn=neutron dose). The 95% confidence limits are 19.3 / √Dn--96.5 / √Dn. (author)

  8. Atomic bomb and leukemia

    Energy Technology Data Exchange (ETDEWEB)

    Ichimaru, Michito; Tomonaga, Masao; Amenomori, Tatsuhiko; Matsuo, Tatsuki (Nagasaki Univ. (Japan). School of Medicine)

    1991-03-01

    Characteristic features of leukemia among atomic bomb survivors were studied. The ratio of a single leukemia type to all leukemias was highest for CML in Hiroshima, and the occurrence of CML was thought to be most characteristic for atomic bomb radiation induced leukemia. In the distribution of AML subtypes of FAB classification, there was no M3 cases in 1 Gy or more group, although several atypical AML cases of survivors were observed. Chromosome study was conducted using colony forming cells induced by hemopoietic stem cells of peripheral blood of proximal survivors. Same chromosome aberrations were observed in colony forming cells and peripheral blood of proximal survivors. (author).

  9. Pathology of atomic bomb casualties.

    Science.gov (United States)

    Iijima, S

    1982-01-01

    Thirty seven years ago, 6 August 1945 marks the date of the first atomic bombing never experienced in human history. It was dropped on Hiroshima and this was followed by a second bombing three days later on Nagasaki. The total deaths following exposure to the bomb by the end of 1945 totalled 140,000 (+/- 10,000) in Hiroshima and 70,000 (+/- 10,000) in Nagasaki. The present article described and outline of the physical effects of the atomic bomb and injury to the human body by exposure to the bomb.

  10. The birth of the atomic bomb

    International Nuclear Information System (INIS)

    Olivier, Louis

    2016-01-01

    In this article, the author proposes an overview of fifty years of researches and works which resulted in the fabrication and use of an atomic bomb. Thus, he evokes the discovery of radioactivity, experiments made by Rutherford, the discovery of nuclear fission induced uranium bombardment by slow neutrons, the discovery of a possibility of chain reaction with a very low critical mass, the first works on the development of a bomb in the USA and United-Kingdom, and finally the Manhattan project and the realisation of the first bombs, tests, and their use in Hiroshima and Nagasaki

  11. Neutron bomb and European defense

    International Nuclear Information System (INIS)

    Sweet, W.

    1980-01-01

    France's development of the controversial neutron bomb is in line with the US goal of flexible response to a Soviet threat in Europe. US neutron bomb production is on a standby basis pending agreement among the North Atlantic Treaty Organization (NATO) members for deployment. Controversy over the bomb centers on its anti-personnel nature, which many see as immoral in comparison with weapons that primarily damage property. Opponents also see it as lowering the nuclear threshold and increasing the chance of nuclear war. Supporters view the bomb as a tactical weapon to be used on a limited scale as a last resort. If Germany's Chancellor Schmidt fails to negotiate a limit to European nuclear arms deployment with the Soviet Union, neutron-bomb production in the US and France will most likely proceed. The prospects for including European nuclear weapons in the Strategic Arms Limitation Talks (SALT) III are jeopardized by the Soviet invasion of Afghanistan and the failure of an early SALT II ratification. 17 references

  12. Neutron bomb and European defense

    Energy Technology Data Exchange (ETDEWEB)

    Sweet, W.

    1980-08-15

    France's development of the controversial neutron bomb is in line with the US goal of flexible response to a Soviet threat in Europe. US neutron bomb production is on a standby basis pending agreement among the North Atlantic Treaty Organization (NATO) members for deployment. Controversy over the bomb centers on its anti-personnel nature, which many see as immoral in comparison with weapons that primarily damage property. Opponents also see it as lowering the nuclear threshold and increasing the chance of nuclear war. Supporters view the bomb as a tactical weapon to be used on a limited scale as a last resort. If Germany's Chancellor Schmidt fails to negotiate a limit to European nuclear arms deployment with the Soviet Union, neutron-bomb production in the US and France will most likely proceed. The prospects for including European nuclear weapons in the Strategic Arms Limitation Talks (SALT) III are jeopardized by the Soviet invasion of Afghanistan and the failure of an early SALT II ratification. 17 references. (DCK)

  13. Tuberculosis among atomic bomb survivors

    International Nuclear Information System (INIS)

    Hamada, Tadao; Matsushita, Hiroshi.

    1980-01-01

    Effects of atomic bomb on tuberculosis among atomic bomb survivors necropsied after 1956 when Atomic Bomb Hospital was opened were observed statistically and the following results were obtained. The morbidity of tuberculosis in the group exposed within 2 km from the hypocenter was higher than that of the control group, but there was not a significant difference between the both groups. The morbidity of all types of tuberculosis was significantly higher in the group exposed within 2 km from the hypocenter than in the control group. The morbidity of tuberculosis tended to decrease in both exposed and non-exposed groups with time. However, the morbidity of miliary or active tuberculosis has tended to rise in the exposed since 1975. The morbidity in young a-bomb survivors exposed within 2 km was higher than that in those of other groups, but there was not a difference in the morbidity among the aged. The higher the rate of complication of active tuberculosis with stomach cancer or acute myelocytic leukemia or liver cirrhosis, the nearer the places of exposure were to the hypocenter. Out of 26 patients with miliary tuberculosis, 6 were suspected to have leukemia while they were alive and were suggested to have leukemoid reaction by autopsy. They all were a-bomb survivors, and 4 of them were exposed within 2 km from the hypocenter. (Tsunoda, M.)

  14. Peace and the Atomic Bomb

    Energy Technology Data Exchange (ETDEWEB)

    Bradbury, Norris E. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Meade, Roger Allen [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    1948-12-02

    A little over three years after assuming the directorship of the Los Alamos Scientific Laboratory, Norris Bradbury returned to his alma mater, Pomona College, and delivered one of his first extended speeches regarding the atomic bomb. Bradbury noted that although the atomic bomb had brought a “peace of kind,” ending World War II, the bomb also had become, without much thought, a “factor in the political, military, and diplomatic thinking of the world.” Bradbury hoped his speech, given to both the faculty and student body of Pomona, would give his audience a foundation on which to assess and understand the new world the bomb had ushered into existence. Bradbury’s talk was quickly printed an distributed by Pomona College and, later, reprinted in The Physical Review (Volume 75, No. 8, 1154-1160, April 15, 1949). It is reprinted here, for a third time, as a reminder of the early days of Los Alamos and its role in international affairs. "Slightly more that three years ago, this country brought to an end the most catastrophic war in history. The conflict had been characterized by an unremitting application of science to the technology of destruction. The final use of the atomic bomb, however, provided a climax so striking that the inevitable nature of future wars was illustrated with the utmost clarity. Peace of a kind followed the first military use of atomic weapons, but international understanding did not, and the atomic bomb became a factor in the political, military, and diplomatic thinking of the world. Where do we now stand in all this? What are the costs and the rewards? Where are we going? These are some of the things that I would like to discuss with you this morning."

  15. Atomic bombs and conspiracy theories

    International Nuclear Information System (INIS)

    Binnie, A.

    2001-01-01

    There have been a number of articles in the press concerning Australia's bid to get the atomic bomb. These articles are based on the recent publication of a book, 'Australia's Bid for the Bomb' by Wayne Reynolds. The book at first sight appears to be very well researched, with many archival references from a number of countries, and the hypotheses appear to be well supported and argued. Its major shortcoming is the way that the science and technology involved is presented. The author seems to have a complete lack of understanding of basic science and engineering principles, and the manner in which scientists and politicians communicate with each other. This paper will attempt to redress these shortcomings, I shall look at the way communities of scientists and politicians present their ideas to each other and to the public at large. By investigating the backgrounds to the establishment of the Snowy Mountains Scheme and the later establishment of the Australian Atomic Energy Commission, the author is able to explain how such a hypothesis ever saw the light of day

  16. RELATIVE BIOLOGICAL EFFECTIVENESS OF NEUTRONS DERIVED FROM THE EXCESS RELATIVE RISK MODEL WITH THE ATOMIC BOMB SURVIVORS DATA MANAGED BY HIROSHIMA UNIVERSITY.

    Science.gov (United States)

    Satoh, Kenichi; Yasuda, Hiroshi; Kawakami, Hideshi; Tashiro, Satoshi

    2017-09-23

    According to an analysis of the Life Span Study cohort data conducted by the Radiation Effects Research Foundation in Hiroshima and Nagasaki, the sex-averaged excess relative risk (ERR) of all solid cancers was 0.42 Gy-Eq-1. On the other hand, analysis of the atomic bomb survivors (ABS) cohort data at Hiroshima University indicated the ERR value was 0.28 Gy-Eq-1 in Hiroshima. In both cases, initial radiation doses were derived from the dosimetry system DS02, in which the relative biological effectiveness (RBE) of neutrons was assumed to be a constant value of 10. To clarify the validity of the RBE, the authors investigated the possibility of different contributions of neutrons by using the ABS. Although there were no statistically significant differences among the estimated value of RBE (=65) and the ordinal value (=10), the corresponding ERR decreased by 30%, which might affect the interpretation of radiation health assessments. © The Author 2017. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  17. Is Einstein the Father of the Atomic Bomb

    Science.gov (United States)

    Lustig, Harry

    2009-05-01

    Soon after the American atomic bombs were dropped on Hiroshima and Nagasaki, the notion took hold in the popular mind that Albert Einstein was ``the father of the bomb.'' The claim of paternity rests on the belief that E=mc2 is what makes the release of enormous amounts of energy in the fission process possible and that the atomic bomb could not have been built without it. This is a misapprehension. Most physicists have known that all along. Nevertheless in his reaction to the opera Dr. Atomic, a prominent physicist claimed that Einstein's discovery that matter can be transformed into energy ``is precisely what made the bomb possible.'' In fact what makes the fission reaction and one of its applications,the atomic bomb, possible is the smaller binding energies of fission products compared to the binding energies of the nuclei that undergo fission.The binding energies of nuclei are a well understood consequence of the numbers and arrangements of protons and neutrons in the nucleus and of quantum-mechanical effects. The realization that composite systems have binding energies predates relativity. In the 19th century they were ascribed to potential and other forms of energy that reside in the system. With Einstein they became rest mass energy. While E=mc2 is not the cause of fission, measuring the masses of the participants in the reaction does permit an easy calculation of the kinetic energy that is released.

  18. Relationship between radioactivity from atomic bomb and leukemia

    International Nuclear Information System (INIS)

    Ishimaru, Toranosuke

    1975-01-01

    A study was made on the atomic bomb survivors in whom leukemia subsquently occurred in Hiroshima and Nagasaki. The incidence of leukemia averaged 30 per one million people 5--26 years after they had been exposed to less than one rad. Among the atomic bomb survivors who had been exposed to 1--99 rads, leukemia occurred within 5--10 years, which showed a slightly higher incidence than that among those who had been exposed to one rad. Among survivors exposed to more than 100 rads, leukemia occurred within 5--10 years on an average of 900 per one million, which was more than 30 times as high as that among those with one rad. Among those aged 15--29 years at the time of bombing, it was high 10--15 years afterward, but was low among those aged 30--44 years at the time of bombing. Among people over 45 years, it became high within 10--15 years, and was still high 15--26 years after bombing. It was suspected that it took 2--3 years after the bombing to develop. From 1950 to 1961, among survivors with exposure to more than 50 rads in Hiroshima, there was a higher incidence of leukemia than there was in Nagasaki. This suggests that neutron-rays have a stronger effect on the incidence of leukemia than have γ-rays. Survivors who had been exposed to neutron-rays in Hiroshima, often had acute or chronic leukemia. On the other hand, some of the survivors with exposure to γ-rays in Nagasaki had only acute leukemia. (Kanao, N.)

  19. Hurricane Ike versus an Atomic Bomb

    Science.gov (United States)

    Pearson, Earl F.

    2013-01-01

    The destructive potential of one of nature's most destructive forces, the hurricane, is compared to one of human's most destructive devices, an atomic bomb. Both can create near absolute devastation at "ground zero". However, how do they really compare in terms of destructive energy? This discussion compares the energy, the…

  20. Colorectal cancer among atomic bomb survivors

    International Nuclear Information System (INIS)

    Nakatsuka, Hirofumi; Ezaki, Haruo.

    1986-01-01

    Studies on autopsied and surgical cases of colorectal cancer in Hiroshima and Nagasaki atomic bomb (A-bomb) survivors have not shown a relationship to radiation. In a recent epidemiologic study made on a fixed population at the Radiation Effects Research Foundation (RERF), the risk of colon cancer was found to increase significantly with increasing radiation dose in both Hiroshima and Nagasaki, and also in both males and females. The dose effect for the cities and sexes combined was especially pronounced for cancer of the sigmoid colon. The effect of radiation was found to vary by age at the time of the bomb (ATB) and the effect was remarkable among those under age 20 ATB. The risk of rectal cancer was not found to increase significantly with radiation and the distribution of histological types for cancer of either the colon or rectum was unrelated to radiation dose. The effect of A-bomb exposure on the postoperative survival rate for colorectal cancer patients was studied. No difference by radiation dose could be demonstrated. In Japan, the incidence of colorectal cancer, and of colon cancer in particular, has been increasing. Therefore, close attention should be paid to changes occurring in A-bomb survivors. (author)

  1. Colorectal cancer among atomic bomb survivors

    International Nuclear Information System (INIS)

    Nakatsuka, H.; Ezaki, H.

    1986-01-01

    Studies on autopsied and surgical cases of colorectal cancer in Hiroshima and Nagasaki atomic bomb (A-bomb) survivors have not shown a relationship to radiation. In a recent epidemiologic study made on a fixed population at the Radiation Effects Research Foundation (RERF), the risk of colon cancer was found to increase significantly with increasing radiation dose in both Hiroshima and Nagasaki, and also in both males and females. The dose effect for the cities and sexes combined was especially pronounced for cancer of the sigmoid colon. The effect of radiation was found to vary by age at the time of the bomb (ATB) and the effect was remarkable among those under age 20 ATB. The risk of rectal cancer was not found to increase significantly with radiation and the distribution of histological types for cancer of either the colon or rectum was unrelated to radiation dose. The effect of A-bomb exposure on the postoperative survival rate for colorectal cancer patients was studied. No difference by radiation dose could be demonstrated. In Japan, the incidence of colorectal cancer, and of colon cancer in particular, has been increasing. Therefore, close attention should be paid to changes occuring in A-bomb survivors

  2. Future population of atomic bomb survivors in Nagasaki.

    Science.gov (United States)

    Yokota, Kenichi; Mine, Mariko; Shibata, Yoshisada

    2013-01-01

    The Nagasaki University Atomic Bomb Survivor Database, which was established in 1978 for elucidating the long-term health effects of the atomic bombing, has registered since 1970 about 120,000 atomic bomb survivors with a history of residence in Nagasaki city. Since the number of atomic bomb survivors has steadily been decreasing, prediction of future population is important for planning future epidemiologic studies, and we tried to predict the population of atomic bomb survivors in Nagasaki city from 2008 to 2030. In addition, we evaluated our estimated population comparing with the actual number from 2008 to 2011.

  3. Diagnosis and treatment of leukemia recognized in atomic-bomb survivors

    International Nuclear Information System (INIS)

    Ichimaru, Michito

    1978-01-01

    Out of atomic bomb survivors in Hiroshima and Nagasaki, 256 patients which were diagnosed as having leukemia by 1975 and of which exposure dose was estimated as over 1 rad were described. Chronic myelocytic leukemia (CGL) was plentiful in Hiroshima, and acute myelocytic leukemia (AGL) was comparatively plentiful in Nagasaki. Chronic lymphatic leukemia (CLL) was not recognized in the atomic bomb survivors exposed at places near the center of the explosion, but CLL was recognized plentifully in the atomic bomb survivors exposed to radiation of under 1 rad. The incidence of leukemia according to the total dose was higher in Hiroshima than in Nagasaki. When RBE of neutron on the occurrence of leukemia was considered to be five times that of gamma-ray, the occurrence curves in both cities were consistent well. As to a relationship between leukemia in the atomic bomb survivors and the age at the exposure time, CGL occurred early in the atomic bomb survivors exposed at an early age. A specific lesion of leukemia in the atomic bomb survivors was not recognized, but cases of which leukemia cells were negative to peroxidase and were very difficult to be identified were plentiful in the atomic bomb survivors exposed within 2 km from the explosion center. The treatment of leukemia in atomic bomb survivors does not differ from that of general leukemia, but a method of treatment, administration dosage, a method and a kind of supportive care must be discussed according to each case. (Serizawa, K.)

  4. On the anti-neutron bomb movement in the Netherlands

    International Nuclear Information System (INIS)

    Hoek, T. van.

    1978-01-01

    The author reports on activities of the Dutch activists group Stop the neutron bomb in his country: Collection of signatures, statements made by about a hundred well-known theologians, two-thirds majority in parliament against the production and emplacement of the neutron bomb, International Forum 1978 in Amsterdam with mass demonstrations. President Carter is said to have been forced to delay the production of the neutron bomb temporarily by means of this international pressure. (HSCH) [de

  5. Health risks of atomic bomb survivors

    International Nuclear Information System (INIS)

    Yoshimoto, Y.; Soda, M.; Mabuchi, K.

    1992-01-01

    At the Atomic Bomb Casualty Commission and its successor organization, the Radiation Effects Research Foundation, mortality and morbidity surveys have been continually carried out on about 1,800 persons exposed in utero to the atomic bombings of Hiroshima and Nagasaki. Although the effect of radiation exposure was marked enough to permit observation of a dose-response relationship in the 30 known cases of severe mental retardation among the in utero-exposed, the association between in utero exposure and cancer risk is still uncertain. Based on data for all cancers from 1950 through 1984 for the in utero-exposed, the excess risk per 10,000 person-year-Gy was 6.57 and the relative risk at 1 Gy was 3.77. For the recent years 1985-89, there was no evident excess of cancer risk. During the remaining lifetime, it seems unlikely that any great excess of leukemia will appear. As for the risk of solid tumors, further follow up is in progress. The 1950-89 findings for cancer risk among the in utero-exposed will be compared with cancer risk among A-bomb survivors who were less than 10 years old at the time of the bombings. (author)

  6. The Manhattan Project: Making the atomic bomb

    Energy Technology Data Exchange (ETDEWEB)

    Gosling, F.G.

    1994-09-01

    This article is a short history of the origins and development of the American atomic bomb program during World War II. Beginning with the scientific developments of the pre-war years, the monograph details the role of US government in conducting a secret, nationwide enterprise that took science from the laboratory and into combat with an entirely new type of weapon. The monograph concludes with a discussion of the immediate postwar period, the debate over the Atomic Energy Act of 1946, and the founding of the Atomic Energy Commission.

  7. Review of dosimetry for the atomic bomb survivors

    International Nuclear Information System (INIS)

    Kerr, G.D.

    1981-01-01

    This paper summarizes and discusses results of some 1980-1981 studies of neutron and γ-ray exposure to the atomic bomb survivors by W.E. Loewe and E. Mendelsohn of the Lawrence Livermore National Laboratory, D.C. Kaul and W.H. Scott of Science Applications, Inc., and J.V. Pace of the Oak Ridge National Laboratory. Some other special studies which are now underway to complete the review will also be discussed. The expert assistance of others in these special studies is being supported in part by the US Department of Energy and in part by the US Defense Nuclear Agency

  8. Mortality of atomic bomb survivors in Nagasaki

    International Nuclear Information System (INIS)

    Mine, Mariko; Honda, Sumihisa; Kondo, Hisayoshi; Yokota, Kenichi; Tomonaga, Masao; Okumura, Yutaka

    1999-01-01

    We analyzed the risk in 2,743 atomic bomb survivors by using a new dosimetry system. From the database, we selected 2,743 exposed persons and a total of three times 2,743 age-matched controls who were living far from the center of the A-bomb radiation in Nagasaki at the time of the explosion and who were still alive in 1971. The mortalities from all causes for male subjects exposed were slightly lower than, or almost equal to, those of unexposed persons. Death from cancer, however, increased in both sexes after all levels of irradiation except in males exposed to 0.01-0.49 Gy. In males, the risk was showed significant reduction in death from all diseases other than cancer classified according to 0.31-0.40 Gy. (author)

  9. Thermal analysis of pyrotechnic mixture-fireworks, atom-bomb

    International Nuclear Information System (INIS)

    Rajendran, Jeya; Thanulingam, T.L.

    2008-01-01

    Sound level produced from two varieties of sound producing fireworks of atom-bomb, cake bomb and thunder bomb were measured. The pyrotechnic mixture, KNO 3 /S/Al(H 3 BO 3 ) of compositions 57.5/19.9/22.1(0.5)% very much similar to commercial atom-bomb were taken and five cake bomb and seven thunder bomb with different net weight of chemicals were manufactured specifically for analysis. Cake bomb with 1g pyrotechnic mixture and thunder bomb with 2g pyrotechnic mixture produce -3 . Ignition temperature of the mixture is above the melting point of the metallic fuel, Al (660 deg C) and self propagating decomposition occurred at high temperature. The pyrotechnic mixture, KNO 3 /S/Al(H 3 BO 3 ) is a safe mixture from accidental factor, static electricity. DSC studies indicate slight formation of potassium nitrite with evolution of NO above 400 deg C. (author)

  10. Chain reaction. History of the atomic bomb

    International Nuclear Information System (INIS)

    Mania, Hubert

    2010-01-01

    Henri becquerel tracked down in 1896 a strange radiation, which was called radioactivity by Marie Curie. In the following centuries German scientists Max Planck, Albert Einstein and Werner Heisenberg presented fundamental contributions to understand processes in the atomic nucleus. At Goettingen, center of the international nuclear physics community, the American student J. Robert Oppenheimer admit to this physical research. In the beginning of 1939 the message of Otto Hahns' nuclear fission electrified researchers. The first step, unleashing atomic energy, was done. A half year later the Second World War begun. And suddenly being friend with and busily communicating physicians were devided into hostile power blocs as bearers of official secrets. The author tells in this exciting book the story of the first atomic bomb as a chain reaction of ideas, discoveries and visions, of friendships, jealousy and intrigues of scientists, adventurers and genius. (orig./GL)

  11. Influence on social life of atomic bomb, chapter 3

    International Nuclear Information System (INIS)

    Anon.

    1979-01-01

    Atomic bombs, for the first time in human history, were dropped on Hiroshima in August 6, and on Nagasaki on August 9, 1945. Though the powers of these bombs were far small as compared with those of present day nuclear weapons, the atomic bombs claimed many lives instantaneously, damaged human bodies, and destroyed all objects, annihilating the urban areas. Even today, the dreadful consequences of the bombings still remain in both body and mind of the victims. Meanwhile, the experiences of atomic bomb disasters are fading constantly. In order to maintain the vivid information, in Part 3 ''Influence on social life'', the following matters are described: relations of the atomic bombings to society; destroyed societies such as disruption of regional societies and loss of wealth; life of the sufferers such as occupation, marriage, hardships of life, orphans, livelihood variation, and suffering of foreigners; and mental process of the sufferers. (J.P.N.)

  12. Autoantibodies and immunoglobulins among atomic bomb survivors

    International Nuclear Information System (INIS)

    Fujiwara, Saeko; Akahoshi, Masazumi; Kodama, Kazunori; Shimaoka, Katsutaro; Akiyama, Mitoshi; Carter, R.L.; Yamakido, Michio

    1994-01-01

    The purpose of this study was to determine if exposure to atomic bomb radiation affects immune responsiveness, such as the occurrence of autoantibodies and levels of immunoglobulins. Rheumatoid factor, antinuclear antibody, antithyroglobulin antibody, anti-thyroid-microsomal antibody and immunoglobulin levels (IgG, IgM, IgA and IgE) were measured among 2,061 individuals exposed to atomic bomb radiation in Hiroshima and Nagasaki whose estimated doses ranged from 0 to 5.6 Gy. The prevalence and titers of rheumatoid factor were found to be increased in the individuals exposed to higher radiation doses. The IgA level in females and the IgM level in both sexes increased as radiation dose increased, although the effects of radiation exposure were not large. No effect of radiation was found on the prevalence of antinuclear antibody, antithyroglobulin antibody and anti-thyroid-microsomal antibody or on the levels of IgG and IgE. 32 refs., 2 figs., 3 tabs

  13. Organ dose estimates for the Japanese atomic-bomb survivors

    Energy Technology Data Exchange (ETDEWEB)

    Kerr, G.D.

    1978-10-01

    Recent studies concerning radiation risks to man by the Committee on Biological Effects of Ionizing Radiation of the National Academy of Sciences-National Research Council and the United Nations Scientific Committee on the Effects of Atomic Radiation have emphasized the need for estimates of dose to organs of the Japanese atomic-bomb survivors. Shielding of internal organs by the body has been investigated for fission-weapon gamma rays and neutrons, and ratios of mean absorbed dose in a number of organs to survivors' T65D assignments of tissue kerma in air are provided for adults. Ratios of mean absorbed dose to tissue kerma in air are provided also for the thyroid and active bone marrow of juveniles. These organ dose estimates for juveniles are of interest in studies of radiation risks due to an elevated incidence of leukemia and thyroid cancer in survivors exposed as children compared to survivors exposed as adults.

  14. Organ dose estimates for the Japanese atomic-bomb survivors

    International Nuclear Information System (INIS)

    Kerr, G.D.

    1978-10-01

    Recent studies concerning radiation risks to man by the Committee on Biological Effects of Ionizing Radiation of the National Academy of Sciences-National Research Council and the United Nations Scientific Committee on the Effects of Atomic Radiation have emphasized the need for estimates of dose to organs of the Japanese atomic-bomb survivors. Shielding of internal organs by the body has been investigated for fission-weapon gamma rays and neutrons, and ratios of mean absorbed dose in a number of organs to survivors' T65D assignments of tissue kerma in air are provided for adults. Ratios of mean absorbed dose to tissue kerma in air are provided also for the thyroid and active bone marrow of juveniles. These organ dose estimates for juveniles are of interest in studies of radiation risks due to an elevated incidence of leukemia and thyroid cancer in survivors exposed as children compared to survivors exposed as adults

  15. Foreign bodies radiographically-demonstrated in atomic bomb survivors

    International Nuclear Information System (INIS)

    Tamura, Shozo; Onitsuka, Hideo; Lee, K.; Shimizu, Yukiko; Russell, W.J.

    1978-01-01

    The prevalence of roentgenologically-detected foreign bodies among atomic bomb (A-bomb) survivors was studied as an indicator of the A-bomb blast effects. Acupuncture was studied as an indicator of A-bomb-related abnormalities for which it was administered. All Adult Health Study subjects' roentgenograms demonstrating foreign bodies were reviewed. The frequency of glass and metal, and acupuncture needles were analyzed by distance from hypocenters, sex, age, body sites involved; and the subjects' shielding at the times of the A-bombs. The presence of glass fragments correlated closely with distance from hypocenter, heavy shielding from the A-bombs, and with adulthood, and they were more frequent in the chest than hand and wrist. Metal foreign bodies were more frequent in the hand and wrist than in the chest, and not associated with distance from hypocenter or heavy shielding. The prevalence of acupuncture needles increased with age, but did not correlate with A-bomb dose. (author)

  16. Aging studies in atomic bomb survivors

    International Nuclear Information System (INIS)

    Belsky, J.L.; Moriyama, I.M.; Fujita, Shoichiro; Kawamoto, Sadahisa.

    1979-07-01

    Although the studies of the effect of ionizing radiation on atomic bomb survivors have not produced any evidence of radiation-induced aging, there have been studies on experimental animals and man which suggest accelerated aging after exposure to ionizing radiation. To determine if certain physiologic functions could be related to exposure to ionizing radiation, a battery of age-related tests was given at the time of the physical examinations at ABCC. Some 11,351 persons were given these non-invasive age-related tests. The results were essentially negative. Until a satisfactory operational definition of biologic or physiologic age is developed, the administration of functional tests as a measure of aging does not seem justified. (author)

  17. The Potentialities of the Atomic Bomb

    Energy Technology Data Exchange (ETDEWEB)

    Meade, Roger Allen [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Bradbury, Norris E. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2017-02-07

    In January 1949, Norris Bradbury gave a lecture at the National War College which summarized the progress Los Alamos had made since the end of the war. The transcript of the talk was filed and forgotten until it surfaced fifty years later. It is, perhaps, one of the best summaries of the state of the United States nuclear weapons program in 1949. It is also evidence of how Bradbury saw the future of atomic weapons. It is presented in full, with minor editing, and begins as follows: Since the first use of an atomic bomb on August 5 [sic], 1945, over the city of Hiroshima, Japan, there has been a continual flood of speculation and discussion concerning the effect of this new weapon on military technology. Much of this speculation and discussion has been intelligent and fruitful; much, I regret to say, has had neither of these characteristics. The enormity of the device, in terms of potential destruction and loss of life, and the practical necessity to surround the technical facts with full security restrictions have only combined to make the problem more difficult. At the same time, it is imperative that policymaking personnel in charge of long range national planning know the basic facts concerning atomic weapons and have these facts in a reasonable perspective. This document describes these potentialities in detail.

  18. Pancreatic exocrine secretion in atomic bomb survivors

    International Nuclear Information System (INIS)

    Hiraoka, Masataka; Kawanishi, Masahiro; Ohtaki, Megu

    1989-01-01

    This study was designed to examine the effect of A-bombing on pancreatic exocrine secretion in 6 A-bomb survivors (an average age of 57 years) and the age- and sex-matched non-exposed 6 persons (an average age of 58 years). Six A-bomb survivors consisted of: three who had been directly exposed to A-bombing, one who had entered the city within 3 days after bombing, one who had worked in caring for A-bomb survivors, and one who had later entered the city. Caerulein-Secretin test revealed no significant difference in the total secretion of lipase, maximum bicarbonate, amylase output, or lipase output between the exposed and non-exposed groups. The concentration of lipase ten min after stimulation was significantly decreased in the exposed group than the control group. This suggests that radiation may be responsible for abnormality in the ability of pancreatic exocrine secretion. (N.K.)

  19. Why the USA dropped atomic bombs on Japanese cities

    International Nuclear Information System (INIS)

    Bernstein, B.

    1997-01-01

    Why did the USA use atomic bombs on Japanese cities? Because, by summer 1945, the earlier morality that said you should not kill non-combatants had been chipped away, then eroded, and ultimately destroyed by World War II. After Hitler's viciousness, after the Japanese rape of Nanjing, after the killings in Manila, after the savagery through Asia, after Dresden, after Hamburg, after Tokyo, Osaka, Kobe, Nagoya - over sixty Japanese cities had been bombed before Hiroshima, Hiroshima was inevitable, easy, comfortable, virtually automatic. The transformation was not the use of bomb, but the bombing of non-combatants - massively, intentionally. There was probably a desire to revenge, as well. In addition, there was an expectation that the bombs used on japan would also intimidate the Soviet Union but that was not crucial. Any nation that had the capacity would have used the bomb in righteousness and comfort, self-conceived dignity, amid popular applause from its electorate people

  20. Teaching and Learning Multiple Perspectives: The Atomic Bomb.

    Science.gov (United States)

    Doppen, Frans H.

    2000-01-01

    Explores how historical empathy can give students a richer understanding of the past, focusing on the development of the students' historical understanding through an analysis of 18 documents on President Truman's decision to use the atomic bomb against Japan. (CMK)

  1. Atomic bomb survivor data: utilization and analysis

    International Nuclear Information System (INIS)

    Prentice, R.L.; Thompson, D.J.

    1984-01-01

    There were several motivations for organizing the SIMS Conference reported in this monograph. Risk assessment and its methods have been subjects of several SIMS Conferences in the recent past, and focusing these newer, more powerful methods on the largest human experience of exposure to ionizing radiation seemed an appropriate sequel. There was also the conviction that the data resources of the Radiation Effects Research Foundation (RERF), generated through the mortality and medical follow-up of large samples of the survivors of the atomic bombs dropped on Hiroshima and Nagasaki, were being under utilized, and that a conference and its proceedings would create interest in exploiting this resource. The time seemed ripe for gathering a small group of current RERF scientists, veteran US statisticians and epidemiologists, and others with more recent entry into the field of radiation biology to consider long range plans for maximizing the output of information not only on the long term effects of ionizing radiation on man but on new knowledge of the determinants of health and disease that can be learned by study of the records of this cohort. This seemed particularly appropriate at this time while intensive joint Japanese-US efforts are underway to provide a new, more accurate dosimetry for use in these studies. Finally, there was a hope that an ad hoc forum of this type would provide not only a summary of current statistical and epidemiologic activities at RERF, but a useful critique of their scope and quality

  2. Infectious diseases in atomic bomb survivors

    International Nuclear Information System (INIS)

    Hamada, Tadao; Ishida, Sadamu; Matsushita, Hiroshi.

    1976-01-01

    Incidences of various infectious diseases in 986 autopsy cases at Hiroshima Atomic Bomb Hospital and Hiroshima Red Cross Hospital from 1965 to 1975 were compared according to the distance from the explosion place, and the following results were obtained. There was not a significant difference at incidences of most infectious diseases between each exposured group and not-exposured group. Incidence of old tuberculosis focus was a little higher in exposured groups, but incidences of main lesions such as tuberculosis, active tuberculosis, and miliary tuberculosis were lower in exposured groups and effect of exposure was negative. Out of urinary tract infections, the nearer the distance to the explosion place was, the higher incidence of cistitis in female was. Incidence of cystitis of female was higher than that of male in the group exposured near to the explosion place. With respect to stomach cancer, leukemia, malignant lymphoma, and cerebrovascular disorder, the nearer the distance to the explosion place was, the higher incidences of various infectious diseases were. (Tsunoda, M.)

  3. Breast cancer in atomic bomb survivors

    International Nuclear Information System (INIS)

    Tokunaga, Masayoshi; Tokuoka, Shoji; Land, C.E.

    1986-01-01

    Thirty eight years after the atomic bombings, studies of the Radiation Effects Research Foundation (RERF) on the extended Life Span Study (LSS) sample have continued to provide important information on radiation carcinogenesis. The third breast cancer survey among this sample revealed 564 cases during the period 1950 - 80, of which 412 were reviewed microscopically. The following statements reflect the conclusions from the current investigation; 1) the relationship between radiation dose and breast cancer incidence was consistent with linearity and did not differ markedly between the Hiroshima and Nagasaki survivors, 2) a dose-related breast cancer risk was observed among women who were in their first decade of life at the time of exposure, 3) the relative risk of radiation-induced breast cancer decreased with increasing age at exposure, 4) the pattern over time of age-specific breast cancer incidence is similar for exposed and control women (that is, exposed women have more breast cancer than control women but the excess risk closely follows normal risk as expressed by age-specific population rates), and 5) radiation-induced breast cancer appears to be morphologically similar to other breast cancer. (author)

  4. Breast cancer in atomic bomb survivors

    International Nuclear Information System (INIS)

    Tokunga, M.; Land, C.E.; Tokuoka, S.

    1986-01-01

    Thirty eight years after the atomic bombings, studies of the Radiation Effects Research Foundation (RERF) on the extended Life Span Study (LSS) sample have continued to provide important information on radiation carcinogenesis. The third breast cancer survey among this sample revealed 564 cases during the period 1950-80, of which 412 were reviewed microscopically. The following statements reflect the conclusions from the current investigation; 1) the relationship between radiation dose and breast cancer incidence was consistent with linearity and did not differ markedly between the Hiroshima and Nagasaki survivors, 2) a dose-related breast cancer risk was observed among women who were in their first decade of life at the time of exposure, 3) the relative risk of radiationinduced breast cancer decreased with increasing age at exposure, 4) the pattern over time of age-specific breast cancer incidence is similar for exposed and control women (that is, exposed women have more breast cancer than control women but the excess risk closely follows normal risk as expressed by age-specific population rates), and 5) radiation-induced breast cancer appears to be morphologically similar to other breast cancer

  5. The Manhattan Project: Making the Atomic Bomb. 1999 edition.

    Energy Technology Data Exchange (ETDEWEB)

    Gosling, F.G.

    1999-01-01

    ``The Manhattan Project: Making the Atomic Bomb`` is a short history of the origins and development of the American atomic bomb program during World War II. Beginning with the scientific developments of the pre-war years, the monograph details the role of the United States government in conducting a secret, nationwide enterprise that took science from the laboratory and into combat with an entirely new type of weapon. The monograph concludes with a discussion of the immediate postwar period, the debate over the Atomic Energy Act of 1946, and the founding of the Atomic Energy Commission.

  6. The Manhattan Project: Making the Atomic Bomb. 1999 edition.

    Science.gov (United States)

    Gosling, F. G.

    1999-01-01

    "The Manhattan Project: Making the Atomic Bomb" is a short history of the origins and development of the American atomic bomb program during World War II. Beginning with the scientific developments of the pre-war years, the monograph details the role of the United States government in conducting a secret, nationwide enterprise that took science from the laboratory and into combat with an entirely new type of weapon. The monograph concludes with a discussion of the immediate postwar period, the debate over the Atomic Energy Act of 1946, and the founding of the Atomic Energy Commission.

  7. Thyroid disorders in atomic-bomb survivors

    International Nuclear Information System (INIS)

    Imaizumi, M.; Neriishi, K.; Akahoshi, M.; Suzuki, G.; Nakashima, E.; Nagataki, S.; Eguchi, K.

    2003-01-01

    It is known from several studies, including those from RERF that radiation exposure can cause thyroid tumors (Socolow, N Engl J Med. 1963;268:406, Parker, Ann Intern Med. 1974;80:600). Effects of radiation on autoimmune thyroid disease are not well understood. We have conducted thyroid disease screening on a population of 2856 individuals from the Adult Health Study (AHS) cohort of atomic-bomb survivors for the period of 1984-1987. This study, which for logistical reasons involved survivors only from Nagasaki, revealed a statistically significant relationship between radiation dose and prevalence of solid nodules, including cancer, and that of autoimmune hypothyroidism (Nagataki, JAMA. 1994;272:364). Because the previous thyroid study was conducted only in Nagasaki, the new comprehensive thyroid disease screening study has been ongoing in Hiroshima and Nagasaki AHS participants since March 2000. For about 4,000 participants in Hiroshima and Nagasaki AHS cohort, thyroid ultrasonography, aspiration biopsy of nodules, thyroid function test, thyroid autoantibody (thyroid peroxidase antibody and thyroglobulin antibody) test by highly sensitive assay using enzyme linked immunosorbent assay were performed for the diagnosis of thyroid diseases. Analysis of data from the 1874 people examined through July 2001 (915 people from Hiroshima, 959 people from Nagasaki) provides evidence that thyroid cancer increases with radiation dose. The prevalence of positive result for thyroid autoantibody test is increased in the people exposed to relative low dose of radiation (0.01-0.99 Sv). Examination and measurements was completed in February 2003 for all patients. The analysis of these data is providing new and more complete insights into relationships between thyroid diseases and low doses of radiation

  8. Survey of radiation doses received by atomic-bomb survivors residing in the United States

    International Nuclear Information System (INIS)

    Kerr, G.D.; Yamada, H.; Marks, S.

    1976-01-01

    A survey has been completed of 300 of an estimated 500 to 750 survivors of the atomic bombings in Hiroshima and Nagasaki who reside in the United States. Distributions with respect to age, sex, citizenship status, distance from the hypocenter at the time of bombing, and dose from immediate weapon radiation have been tabulated from the results and are presented for this group of 300 survivors. Also presented are survey results concerning exposures to residual radiation from fallout and neutron-induced radioactivity in the areas adjacent to the hypocenter

  9. Foreign bodies radiographically-demonstrated in atomic bomb survivors

    Energy Technology Data Exchange (ETDEWEB)

    Tamura, S.; Onitsuka, H.; Lee, K.; Shimizu, Y.; Russell, W.J.

    1978-08-25

    The prevalence of roentgenologically-detected foreign bodies among atomic bomb (A-bomb) survivors was studied as an indicator of the A-bomb blast effects. Acupuncture was studied as an indicator of A-bomb-related abnormalities for which it was administered. All Adult Health Study subjects' roentgenograms demonstrating foreign bodies were reviewed. The frequency of glass and metal, and acupuncture needles were analyzed by distance from hypocenters, sex, age, body sites involved; and the subjects' shielding at the times of the A-bombs. The presence of glass fragments correlated closely with distance from hypocenter, heavy shielding from the A-bombs, and with adulthood, and they were more frequent in the chest than hand and wrist. Metal foreign bodies were more frequent in the hand and wrist than in the chest, and not associated with distance from hypocenter or heavy shielding. The prevalence of acupuncture needles increased with age, but did not correlate with A-bomb dose.

  10. Accident in science history. Hitler's atomic bomb

    International Nuclear Information System (INIS)

    Popp, Manfred

    2016-01-01

    Up to now the historical explanation for the fact that NS Germany did not develop an atomic bomb was that there was enough scientific and technical knowledge but not enough resources. Recent historical research showed that the German scientists in the ''Uranverein'' did not know the cross section of U-235 and had no possibility to measure these cross sections. There exist only very few documents dealing with the bomb. The bomb was treated as a special case of a reactor. Obviously the German scientists did not know he bomb technology. It seems that the project was not success-oriented because the scientists expected to be sent to the front in case of a project stop.

  11. Aging studies in atomic bomb survivors

    International Nuclear Information System (INIS)

    Belsky, J.L.; Moriyama, I.M.; Fujita, Seiichiro; Kawamoto, Sadahisa.

    1980-01-01

    Though acceleration of aging induced by radiation could not be demonstrated in many investigations on delayed effects of ionizing radiation on a-bomb survivors, studies on acceleration of aging after the exposure to ionizing radiation in human and animals have been carried out. To investigate whether physiological function was related to the exposure to ionizing radiation, a series of examinations concerning age was carried out at the time of general health examinations at ABCC. Simple examinations concerning aging were carried out on 11,351 a-bomb survivors, but the result was essentially negative. If biological or physiological age was defined clearly, the results of functional test would be used as criterion of aging. (Tsunoda, M.)

  12. Foreign bodies radiographically demonstrated in atomic bomb survivors

    Energy Technology Data Exchange (ETDEWEB)

    Tamura, S.; Onitsuka, H.; Lee, K.K.; Shimizu, Y.; Russell, W.J.

    1978-02-01

    The prevalence of roentgenologically-detected foregin bodies among atomic bomb survivors was studied as an indicator of the A-bomb blast effects. Acupuncture was studied as an indicator of possible A-bomb-related abnormalities for which it was administered. All available roentgenograms of Adult Health Study (AHS) subjects which demonstrated foreign bodies were reviewed. The frequency of glass and metal foreign bodies and of acupuncture needles was analyzed in detail. Analyses were made by distance from the hypocenter, sex, age, body sites involved, and shielding at the time of the A-bomb (ATB). The presence of glass fragments correlated closely with distance from the hypocenter, with heavy shielding from the A-bombs, and with adulthood, and they were more frequent in the chest than in the hand and wrist. On the contrary, metal foreign bodies were more frequent in the hand and wrist than in the chest, and were not associated with distance from hypocenter or heavy shielding. The prevalence of acupuncture needles increased with age, but did not correlate with A-bomb dose.

  13. Current trend of malignant neoplasms among atomic bomb survivors

    International Nuclear Information System (INIS)

    Hamada, Tadao

    1984-01-01

    A survey was made on 7,589 admitted patients and 1,965 autopsy cases. The overall incidence of malignant neoplasms tended to decrease in the group exposed to atomic bomb within 2 km in autopsy cases and to increase in admitted patients. The incidence of pulmonary cancer tended to increase in both autopsy cases and admitted patients. The incidence of gastric cancer tended to increase up to 1975, and thereafter tended to decrease. The incidence of liver cancer tended to increase in both autopsy cases and admitted patients, which was marked in males. The incidence of leukemia was high in the group exposed to atomic bomb within 2 km in autopsy cases, and in the group within 1 km and the group which entered the city after the explosion in admitted patients. The incidence of malignant lymphoma tended to decrease, and the incidence of carcinoma of the colon tended to gradually increase in both autopsy cases and admitted patients. The incidence of multiple carcinomas tended to increase in both atomic bomb exposed group and non-exposed group, being higher in atomic bomb group than in non-exposed group. The incidence of breast cancer became constant since 1970. The incidence of carcinoma of the thyroid gland tended to decrease, although it was high in the group exposed near the explosion. (Namekawa, K.)

  14. Malignant Lymphoma in an Atomic-bomb Survivor

    Directory of Open Access Journals (Sweden)

    Cheng-Chia Lee

    2009-07-01

    Full Text Available Atomic bomb survivors outside of Japan are few and often hard to follow-up. Spinal malignant lymphoma among these survivors is rare in established studies from Japan or the United States. Here, we report an 81-year-old woman, who experienced the atomic bomb explosion in Nagasaki when she was 19 years old, who presented with papillary thyroid carcinoma when she was 70 years old. Both follicular lymphoma over the right elbow region and vertebral malignant lymphoma were found when she turned 81 years old. Bone scan did not show any increased uptake of isotope. However, thoracolumbar spine magnetic resonance imaging showed multiple infiltrative soft tissue masses involving vertebral bodies at the T10–11 level. Computed tomography-guided biopsy further showed lymphocyte infiltration. Fortunately, the neurological deficit was improved after chemotherapy. The diagnosis of malignant lymphoma in atomic bomb survivors should be more careful and aggressive, even when their bone scan results show negative findings. In addition, the authors suggest that atomic bomb survivors should be followed-up carefully throughout their entire life.

  15. Lymphocyte cytotoxicity of colchicine in Hiroshima atomic bomb survivors

    International Nuclear Information System (INIS)

    Caplan, R.A.; Odoroff, C.L.; Ozaki, Kyoko; Hamilton, H.B.; Finch, S.C.

    1979-07-01

    The cytotoxicity of colchicine for the peripheral blood lymphocytes of 151 Hiroshima atomic bomb survivors and their controls was determined. No radiation effect was found, but modest age-related changes for the initial number of vialble cells and for the cytotoxicity of colchicine were observed. (author)

  16. The development of the first Soviet atomic bomb

    International Nuclear Information System (INIS)

    Goncharov, German A; Ryabev, Lev D

    2001-01-01

    In the late 1930s and early 1940s, two remarkable physical phenomena - the fission of heavy nuclei and the chain fission reaction - were discovered, implying that a new powerful source of energy (nuclear fission energy) might become a practical possibility for mankind. At that time, however, the political situation in the world made the development of the atomic bomb the main objective of nuclear energy research in the countries involved. The first atomic bombs, notoriously used in the war against Japan, were produced by the United States of America only six and a half years after the discovery of fission. Four years later, the first Soviet atomic bomb was tested. This was a major step toward the establishment of nuclear parity which led to stability and global peace and thus greatly influenced the destiny of human kind. Based on documentary materials covering the period from 1939 to 1949, this paper traces the origin and evolution of the physical ideas behind the first Soviet atomic bomb and discusses the most important events associated with the project. (from the history of physics)

  17. Atomic Bomb: Memory and its Power on Japanese Pacifism

    Science.gov (United States)

    2008-05-01

    incentives and most importantly any manipulation of the atomic bomb memory. The most devastated members of Japan’s society however, would be the...The Rape of Nanking. New York: Penguin Books, 1998. Chomsky , Noam. Intervention. San Francisco: City Lights Books, 2007. Christopher, Robert C. The

  18. Aplastic anemia and related disorders in atomic bomb survivors

    International Nuclear Information System (INIS)

    Ichimaru, Michito; Tomonaga, Yu; Matsunaga, Masako; Sadamori, Naoki; Ishimaru, Toranosuke.

    1978-01-01

    Whether the incidence of aplastic anemia significantly increases due to the later effect of atomic-bomb radiation was studied. After the data of aplastic anemia which occurred within 1950 - 1973 were evaluated and the diagnoses of the cases were certified, the incidence of aplastic anemia per 109,000 inhabitants of the cities of Hiroshima and Nagasaki was calculated and compared according to the dose of atomic-bomb radiation. There was no increase in the incidence according to an increase in radiation dose, and there was no fact that aplastic anemia increased in a certain period either. Most of the atomic-bomb survivors who were close to the epicenter and were clinically diagnosed as aplastic anemia had leukemia lesion or myeloid proliferating lesion, and it is likely to be that pathological changes resembling aplastic anemia may appear in a certain phase of myeloid proliferation or as a phenotype of myeloid proliferation. An evaluation was made on cases of aplastic anemia of other groups, but the doses of atomic-bomb radiation which they received were not so much to give effect on the bone marrow except only two cases. (Ueda, J.)

  19. Nutritional survey of atomic bomb survivors, 1

    International Nuclear Information System (INIS)

    Murakami, Fumiyo; Tanigawa, Junko; Ito, Chikako

    1978-01-01

    136 cases in which mild anemia was recognized but stomach disease was not recognized by the examination for a-bomb survivors, were investigated concerning living conditions, the habit of food, and the intake amount of nutrition, and the following results were obtained. 1. The mean intake amount of nutritive substances in a-bomb survivors almost reached the level as compared to the necessary amount of nutritive substances in control. 2. Shortage in intake of protein and iron which seemed to be a factor of occurrence of anemia (protein: 50% in men and 19.7% in women, iron: 25% in men and 22.5% in women), much and frequent intake of confectioneries and luxuries, and the rate of going without meal (33.3% of men went without meal one to 6 times a week) were recongized in each case of anemia with high rate. These tendency was marked in men. 3. Anemia was recognized in some of women, although they took all nutritive substances. This seemed to be caused by physiological loss of iron. Accordingly, it was desirable to take an excess amount of iron. (Tsunoda, M.)

  20. The mental health state of atomic bomb survivors

    Energy Technology Data Exchange (ETDEWEB)

    Nakane, Yoshibumi; Imamura, Yoshihiro; Yoshitake, Kazuyasu; Honda, Sumihisa; Mine, Mariko; Hatada, Keiko; Tomonaga, Masao [Nagasaki Univ. (Japan). School of Medicine; Tagawa, Masuko

    1997-03-01

    Our department of Neuropsychiatry has clarified the clinical features of several mental disorders and surveyed the causes of those disorders from the psychosocial aspect using the methodology of epidemiological psychiatric approach. Using this previous research experience, we began a long-planned study to examine the mental health state of atomic bomb survivors. Fifty-one years have passed since the atomic bombing, and the survivors must have suffered various psychosocial stresses, other than any direct effect on the central nervous system from exposure to radiation, and it is assumed that victims` mental state has been affected in various ways as a result. The subjects of the survey were 7,670 people who had regular health examinations for atomic bomb survivors during the study period of three years and who consented to participate in the study. Of the total, 226 subjects were selected for a second phase according to the results of the General Health Questionnaire 12-item Version which was used in the first phase of the survey. The results were as follows: 1. The distance from the hypocenter was related to the degree of ill health, and the percentage of people with a high score was greater among those exposed to the atomic bomb in proximity to the hypocenter. 2. 14.6% of the subjects were diagnosed as having some kind of mental disorders according to clinical interviews by trained psychiatrists. These results had not expected prior to the study. On the based of the study, we will try to establish a mental health support system for atomic bomb survivors. (author)

  1. The mental health state of atomic bomb survivors

    International Nuclear Information System (INIS)

    Nakane, Yoshibumi; Imamura, Yoshihiro; Yoshitake, Kazuyasu; Honda, Sumihisa; Mine, Mariko; Hatada, Keiko; Tomonaga, Masao; Tagawa, Masuko

    1997-01-01

    Our department of Neuropsychiatry has clarified the clinical features of several mental disorders and surveyed the causes of those disorders from the psychosocial aspect using the methodology of epidemiological psychiatric approach. Using this previous research experience, we began a long-planned study to examine the mental health state of atomic bomb survivors. Fifty-one years have passed since the atomic bombing, and the survivors must have suffered various psychosocial stresses, other than any direct effect on the central nervous system from exposure to radiation, and it is assumed that victims' mental state has been affected in various ways as a result. The subjects of the survey were 7,670 people who had regular health examinations for atomic bomb survivors during the study period of three years and who consented to participate in the study. Of the total, 226 subjects were selected for a second phase according to the results of the General Health Questionnaire 12-item Version which was used in the first phase of the survey. The results were as follows: 1. The distance from the hypocenter was related to the degree of ill health, and the percentage of people with a high score was greater among those exposed to the atomic bomb in proximity to the hypocenter. 2. 14.6% of the subjects were diagnosed as having some kind of mental disorders according to clinical interviews by trained psychiatrists. These results had not expected prior to the study. On the based of the study, we will try to establish a mental health support system for atomic bomb survivors. (author)

  2. Preleukemic state in atomic bomb survivors

    International Nuclear Information System (INIS)

    Mikami, Motoko

    1980-01-01

    Hematology data before onset of leukemia were available for 55 of the 1462 acute leukemia cases (as of the end of June 1976) collected by RERF. Among these, 8 showed preleukemic state and 2 were polycythemia. In content, preleukemic state comprised anemia, leukopenia and morphological abnormalities of RBC, platelets and WBC. Leukemia cases presenting preleukemic state were, by type, mostly erythroleukemia and monocytic leukemia. Preleukemic state was not necessarily frequent among cases of leukemia in A-bomb survivors exposed to high dose. The prevalence of the 5 items, prescribed as preleukemic state, i.e., anemia (female =50%), and relative monocytosis (>=10%), could not be said to be high in the survivors exposed to high dose. Anemia in males and leukopenia in males and females were increased significantly with age. Leukemia prevalence was significantly high especially in those cases that had presented leukopenia, relative neutropenia or relative lymphocytosis among the 5 items prescribed as preleukemic state. (author)

  3. Leukemia and lymphoma in atomic bomb survivors

    International Nuclear Information System (INIS)

    Finch, S.C.

    1984-01-01

    Leukemia has been observed to increase with increasing radiation dose in the A-bomb survivors of Hiroshima and Nagasaki. The first radiation-related cases occurred 3 to 5 years following exposure. The peak incidence years were about 7 to 8 years following exposure and the leukemogenic effect has decreased since that time, but it may last for 40 years or longer in the most heavily exposed persons. A bimodal susceptibility pattern was observed, with peaks following exposure during childhood and after age 50. Latent periods for the development of acute leukemia were shortest in the younger exposed persons. Both acute and chronic forms of leukemia occurred in exposed persons at younger ages in life than normally is expected. The most common types of radiation-induced leukemia were acute and chronic granulocytic in adults and children, and acute lymphocytic in children. The highest radiation-related leukemia risk was for chronic granulocytic leukemia following childhood exposure

  4. Epidemiologic study of skin cancer in Nagasaki atomic bomb survivors

    Energy Technology Data Exchange (ETDEWEB)

    Sadamori, Naoki; Mine, Mariko (Nagasaki Univ. (Japan). School of Medicine)

    1989-01-01

    Data from 140 A-bomb survivors with skin cancer were analyzed with the purpose of elucidating the relationship between atomic bombing and skin cancer. The incidence of skin cancer was significantly correlated with the distance from the hypocenter (p<0.01), regardless of sex. Basal cell epithelioma was the most predominant, followed by squamous cell carcinoma. Histology of skin cancer seemed independent of the distance. Since 1965, the incidence of skin cancer has been increased with aging in A-bomb survivors exposed at le2500 m from the hypocenter. It has been significantly higher since 1975 in the le2500 m group than in the ge3000 m group. (N.K.).

  5. Health effects of atomic-bomb radiation

    International Nuclear Information System (INIS)

    Nakamura, Nori

    2000-01-01

    This review described carcinogenic and genetic effects of A-bomb radiation. Effects have been investigated on 120,000 exposed people for their life span, 20,000 for health examinations, 3,000 people exposed in the womb and 80,000 second-generations of the exposed people. Epidemiological data revealed the presence of carcinogenic effects: Cancer death amounted to 9% from 1950 to 1990. However, carcinogenic mechanism is unknown yet. Genetic effects have been studied from the points of lesion at birth, sex ratio, chromosome aberration, biochemical test and mortality rate of children of exposed people and, although the effects have been experimentally shown in animals, are not observed in those children. This may be derived from the fact that there are few people who were exposed to such a high dose as used experimentally (0.2 Sv exposure to people within 2.5 km diameter-area from the explosion point vs >3 Sv in animals). Data are presented in Research Foundation home page. (K.H.)

  6. The Manhattan Project: Making the Atomic Bomb. 2010 edition.

    Energy Technology Data Exchange (ETDEWEB)

    Gosling, F. G.

    2010-01-15

    This historical document is part of a planned 3-volume series. This volume, volume 1, provides a short history of the origins and development of the American atomic bomb program during World War II. Beginning with the scientific developments of the pre-war years, the monograph details the role of the United States government in conducting a secret, nationwide enterprise that took science from the laboratory and into combat with an entirely new type of weapon. The monograph concludes with a discussion of the immediate postwar period, the debate over the Atomic Energy Act of 1946, and the founding of the Atomic Energy Commission.

  7. The Rhetoric of "Unconditional Surrender" and the Decision to Drop the Atomic Bomb.

    Science.gov (United States)

    Hikins, James W.

    1983-01-01

    Analyzes the decision to drop the atomic bomb from a rhetorical point of view, arguing that the bombs were launched because of an American commitment to a particular rhetoric that focused on the propaganda slogan "unconditional surrender." (PD)

  8. A review of colorectal cancer in atomic bomb survivors

    International Nuclear Information System (INIS)

    Nakao, Susumu; Sawai, Terumitsu; Ishii, Toshiyo; Eida, Kazuyuki; Noguchi, Kyoichi; Takahara, Osamu

    1989-01-01

    Clinical and pathological characteristics of patients with colorectal cancer amongst atomic bomb survivors, who had undergone operations from 1971∼1984, have been reviewed and compared with that of a control group. The survival rate of the atomic bomb survivors over the age of 60 years was statistically better than that of the same age group in the controls. In this age bracket, the control group were in a more advanced stage of the disease than were the survivors, this accounting for the reason why the survivors had better prognosis. Further, the fact that the survivors continually have received more medical attention than have the aged in the control group affects this statistic. (author)

  9. Food habits in atomic bomb survivors suffering from malignant neoplasms

    International Nuclear Information System (INIS)

    Morimoto, Kazue; Inoue, Hisako; Uchino, Chito

    1984-01-01

    Food habits were surveyed in patients admitted to 13 hospitals in Nagasaki prefecture and other prefectures to compare the incidence of malignant neoplasms according to the food intake between atomic bomb exposed group and non-exposed group. The incidence of malignant neoplasms was significantly higher in male patients having the low intake of milk and salted fish than in those having the high intake of them in atomic bomb exposed group, while it was significantly higher in male patients having the low intake of potatoes and milk and in female patients having the low intake of boiled fish paste than in those having the high intake of them in non-exposed group. (Namekawa, K.)

  10. Surveys right after the atomic bombing and a relief squad

    Energy Technology Data Exchange (ETDEWEB)

    Mine, Mariko [Nagasaki Univ. (Japan). School of Medicine

    1998-12-01

    An outline of four survey reports right after the atomic bombing in Nagasaki and Hiroshima is introduced. The report of Manhattan District Atomic Bomb Investigating Groups: The subjects of this survey were 900 inpatients in Nagasaki (for 16 days from September 20) and Hiroshima (for 5 days from October 3). Two hundreds and forty-nine patients (16%) died. In cases died without injury, the severe symptoms were alopecia, purpura, hemorrhage, oral cavity and pharynx lesion, vomiting, diarrhea and fever. The residual radioactivity measured at six weeks later was 6-25 roentgen in Hiroshima and 30-110 roentgen in Nagasaki (Nishiyama riverhead area). These values were lower than the predicted value from the clinical consequence. The report of Joint Commission for the Investigation of the Atomic Bomb: Following the above survey, about 6500 subjects were investigated both in Nagasaki and Hiroshima. Incidence of alopecia was investigated by shielded situation at a spot of 2.1 to 2.5 km from a blast center. It was 7.2% of outdoors (shielded: 7.3%, non-shielded: 17.4%) and 2.9% of indoors. The report of the Special Committee for Atomic Bomb Casualty Investigation and Research of the Scientific Research Council of Japan: General part of the report consists of medical part and physical part, and reports from each university were classified and listed in the supplement. Survey of Nagasaki Medical College (not in public): About 8000 subjects were investigated from October to December. Data were gathered up about lethality, time of death, injury and radiation sickness, etc. There was also autograph of a relief squad of the Nagasaki Medical College. (K.H.)

  11. Profiles of non-cancer diseases in atomic bomb survivors

    International Nuclear Information System (INIS)

    Kazunori Kodama; Saeko Fujiwara; Michiko Yamada; Fumiyoshi Kasagi; Yukiko Shimizu; Itsuzo Shigematsu

    1996-01-01

    This article summarizes the results of a recent study of atomic bomb radiation and non-cancer diseases in the AHS (Adult Health Study) population by the RERF (Radiation Effects Research Foundation) along with a general discussion of previous studies. Recent studies have demonstrated almost certainly that uterine myoma is more frequent among atomic bomb survivors. It cannot, at present, be concluded that uterine myoma is caused by radiation, because there are no reported studies of other exposed populations. Further analyses including the role of confounding factors as well as molecular approaches are needed to verify this radiation effect. The relationship between atomic bomb radiation exposure and hyperparathyroidism can now be said to have been established in view of the strong dose response, the agreement with results of studies of other populations, the high risk in the younger survivors, and the biological plausibility. Future studies by molecular approaches, etc., are needed to determine the pathogenic mechanism. Among other benign tumours, a dose response has been demonstrated for tumours of the thyroid, stomach and ovary. Although fewer studies have been conducted than for cancer, a clear association between radiation and various benign tumours is emerging. 79 refs, 5 figs, 1 tab

  12. Leukemia in Hiroshima atomic bomb survivors from 1946 to 1975

    International Nuclear Information System (INIS)

    Ohkita, Takeshi

    1976-01-01

    In five recent years, 134 deaths from leukemia among Hiroshima citizen were recorded. Of these, 23 cases (17 acute and 6 chronic types) were atomic bomb survivors exposed within 2,000 m of the hypocenter. Fifteen of them (65%) were over 60 years of age. The frequency of chronic lymphocytic leukemia was still low. Although the risk of leukemia was greatly reduced after 1961, and the frequency of chronic granulocytic leukemia (one of the most characteristic type of Hiroshima atomic bomb-induced leukemia) was also decreased, the death rate from leukemia among survivors exposed within 2,000 m or 1,500 m from the hypocenter was about 3 to 4 times higher than the mean death rate in all Japan. Therefore, careful and long-range follow-up surveillance should be continued. A brief review was also made of relevant studies such as the influence of environmental and host factors in the epidemiology of leukemia, the incidence of leukemia in children exposed in utero, and leukemia in offspring of atomic bomb survivors. (Evans, J.)

  13. Einstein, Ethics and the Atomic Bomb

    Science.gov (United States)

    Rife, Patricia

    2005-03-01

    Einstein voiced his ethical views against war as well as fascism via venues and alliances with a variety of organizations still debated today. In 1939, he signed a letter to President Roosevelt (drafted by younger colleagues Szilard, Wigner and others) warning the U.S.government about the danger of Nazi Germany gaining control of uranium in the Belgian-controlled Congo in order to develop atomic weapons, based on the discovery of fission by Otto Hahn and Lise Meitner. In 1945, he became a member of the Princeton-based ``Emergency Committee for Atomic Scientists'' organized by Bethe, Condon, Bacher, Urey, Szilard and Weisskopf. Rare Einstein slides will illustrate Dr.Rife's presentation on Albert Einstein's philosophic and ethical convictions about peace, and public stance against war (1914-1950).

  14. Findings of a recent ORNL review of dosimery for the Japanese atomic-bomb survivors

    International Nuclear Information System (INIS)

    Kerr, G.D.

    1981-01-01

    More detail than previously available on the leakage spectra of neutrons from the Nagasaki and Hiroshima weapons was provided by calculations made at the Los Alamos National Laboratory in 1976. Several neutron-transport calculations using these data predicted significantly less neutron exposure in Hiroshima than the current radiation-exposure estimates for survivors designated as T65D (or Tentative 1965 Doses). The difference was extremely important since recent studies using the T65D estimates have predicted a very large leukemia risk for neutrons at low exposure levels in Hiroshima. Some findings are that the neutron exposures in Hiroshima were probably less than the T65D estimates by factors varying from about four at a ground distance of 1000 m to eight at 2000 m, and the gamma-ray exposures were greater than the T65D estimates starting at about 1000 m and were probably larger by a factor of about three at 2000 m. In Nagasaki, the situation was reversed with respect to gamma rays, and the T65D estimates were higher, but the differences were small (i.e., about 20% at 1000 m and 30% at 2000 m). As a result, it now appears that leukemia and other late effects at lower exposure levels in Hiroshima were due largely to gamma rays rather than neutrons. This may not be true at higher exposure levels in Hiroshima, however. Any reanalysis of data on late effects among the atomic-bomb survivors should be regarded as highly speculative until some other important issues have been investigated in more detail. These issues include the anisotropy in neutron leakage from the Hiroshima weapon, the energy yield of the Hiroshima weapon, the shielding factors for houses, and the organ-dose factors for the atomic-bomb survivors

  15. Deep underground measurements of 60Co in steel exposed to the Hiroshima atomic bomb explosion.

    Science.gov (United States)

    Hult, Mikael; Gasparro, Joël; Vasselli, Roberto; Shizuma, Kiyoshi; Hoshi, Masaharu; Arnold, Dirk; Neumaier, Stefan

    2004-01-01

    When using gamma-ray spectrometry performed deep underground, it is possible to measure 60Co activities down to 0.1 mBq in steel samples of some 100 g without any pre-concentration. It is thus still possible to measure 60Co induced by neutrons from the atomic bomb explosion in Hiroshima in pieces of steel collected at distances up to about 1200 m slant range. The results of non-destructive measurements of eight steel samples are compared with the 1986 Dose Re-Evaluation (DS86) model calculations.

  16. Deep underground measurements of 60Co in steel exposed to the Hiroshima atomic bomb explosion

    International Nuclear Information System (INIS)

    Hult, Mikael; Gasparro, J.Joeel; Vasselli, Roberto; Shizuma, Kiyoshi; Hoshi, Masaharu; Arnold, Dirk; Neumaier, Stefan

    2004-01-01

    When using gamma-ray spectrometry performed deep underground, it is possible to measure 60 Co activities down to 0.1 mBq in steel samples of some 100 g without any pre-concentration. It is thus still possible to measure 60 Co induced by neutrons from the atomic bomb explosion in Hiroshima in pieces of steel collected at distances up to about 1200 m slant range. The results of non-destructive measurements of eight steel samples are compared with the 1986 Dose Re-Evaluation (DS86) model calculations

  17. Deep underground measurements of {sup 60}Co in steel exposed to the Hiroshima atomic bomb explosion

    Energy Technology Data Exchange (ETDEWEB)

    Hult, Mikael E-mail: mikael.hult@cec.eu.int; Gasparro, J.Joeel; Vasselli, Roberto; Shizuma, Kiyoshi; Hoshi, Masaharu; Arnold, Dirk; Neumaier, Stefan

    2004-09-01

    When using gamma-ray spectrometry performed deep underground, it is possible to measure {sup 60}Co activities down to 0.1 mBq in steel samples of some 100 g without any pre-concentration. It is thus still possible to measure {sup 60}Co induced by neutrons from the atomic bomb explosion in Hiroshima in pieces of steel collected at distances up to about 1200 m slant range. The results of non-destructive measurements of eight steel samples are compared with the 1986 Dose Re-Evaluation (DS86) model calculations.

  18. One minute after the detonation of the atomic bomb: the erased effects of residual radiation.

    Science.gov (United States)

    Takahashi, Hiroko

    2009-01-01

    The U.S. Government's official narrative denies the effects of residual radiation which appeared one minute after the atomic bomb detonations in Hiroshima and Nagasaki. This paper explores declassified documents from the U.S. Atomic Energy Commission, the Atomic Bomb Casualties Commission, and others and shows that these documents actually suggested the existence of serious effects from residual radiation.

  19. Radiation therapy among atomic bomb survivors, Hiroshima and Nagasaki

    International Nuclear Information System (INIS)

    Pinkston, J.A.; Antoku, Shigetoshi; Russell, W.J.

    1980-10-01

    In the continuing evaluations of atomic bomb survivors for late radiation effects, not only doses from the A-bombs but those from other radiation sources must be considered, for the latter may be concomitantly acting factors causing bias among these investigations. In the present study, among 73 Hiroshima and 22 Nagasaki Adult Health Study (AHS) subjects who reported receiving radiation therapy, from 1970 through 1979, the medical records of 72 and 20, respectively, were reviewed, and 41 Hiroshima and 14 Nagasaki subjects were confirmed to have received radiation therapy. The data obtained in the present study were pooled with those of the previous investigation on radiation therapy exposures of AHS subjects prior to 1970. A total of 190 subjects have been documented as receiving radiation therapy and their doses were estimated. Energies used in treatments and diseases treated are discussed. Malignancies developed subsequent to radiation therapy in seven cases; five after treatment for malignancies and two after treatment for benign diseases. Neoplasms of 12 AHS subjects may have been induced by earlier radiation therapy; 5 in the earlier study and 7 in the present one. These investigations underscore the need for continued documentation of exposures to ionizing radiation for medical reasons, especially from sources incurring relatively high doses. Bias in assessments of late radiation effects among A-bomb survivors can thus be avoided. (author)

  20. Two cases of giant parathyroid adenoma in atomic bomb survivors

    International Nuclear Information System (INIS)

    Takeichi, Nobuo; Nishida, Toshihiro; Fujikura, Toshio

    1983-12-01

    In a study of parathyroid tumor among autopsy cases at RERF in Hiroshima, 16 cases of parathyroid adenoma were detected among 4,136 autopsies during 1961-77. Of these, two cases were giant adenoma (5 cm in diameter) accompanied by hyperparathyroidism. Both cases were atomic bomb survivors from Hiroshima. One was exposed to 55 rad at age 51 and died at age 71, and the other was exposed to 28 rad at age 45 and died at age 71. These two cases will be reported together with a review of the literature on parathyroid tumors developed following irradiation on the head and neck. (author)

  1. Radiosensitivity of skin fibroblasts from atomic bomb survivors with and without breast cancer

    International Nuclear Information System (INIS)

    Ban, Sadayuki; Setlow, R.B.; Bender, M.A.

    1990-11-01

    Fibroblasts were established in vitro from skin biopsies obtained from 55 women and one man with or without breast cancer and with or without exposure to radiation from the atomic bomb explosion in Hiroshima. The radiosensitivity of these cells was evaluated by clonogenic assays after exposure to X rays or to fission neutrons from a 252 Cf source. Data were fitted to a multitarget model, S/S 0 = A[1-(1-e kD ) N ], for both X-ray and neutron dose-survival curves. A single-hit model, S/S 0 = Ae kD , fits the neutron dose-survival responses as well. These was no difference in the means or variances of radiosensitivity between exposed and nonexposed groups, or between patients with or without breast cancer. Hence, although the sample is not large, it provides no support for the hypothesis that A-bomb radiation preferentially induces breast cancer in women whose cells in vitro are sensitive to cell killing by radiation. (author)

  2. Axial length of atomic bomb survivors in Nagasaki

    International Nuclear Information System (INIS)

    Wakiyama, Harumi; Kishikawa, Yasuhiro; Imamura, Naoki; Amemiya, Tsugio

    2002-01-01

    We reviewed a series of 778 patients who had cataract surgery during the past 4 years at the Nagasaki Atomic Bomb Memorial Hospital. We evaluated the history of exposure to radiation by atomic bomb in 1945, axial length and state of refraction. All were born before 1945. The series comprised 263 males and 515 females. Their ages averaged 76.5±8.6 years. History of exposure to radiation was present in 356 patients. The remaining 422 patients served as control. There was no difference in the type of cataract between the two groups. High myopia was present in 11 irradiated patients (3.2%) and in 24 patients in the control group (6.0%). The difference was not significant (p=0.083). There was no high myopia among 24 patients who were aged 18 years or less at the time of radiation and who were within 2 km from the epicenter. No difference was present regarding the axial length between the two groups or between both sexes. The present result is not definitive because ''irradiated group'' would include those with little or no exposure and because precise data has not been available about the dosis of radiation. (author)

  3. Radiation and cancer risk in atomic-bomb survivors.

    Science.gov (United States)

    Kodama, K; Ozasa, K; Okubo, T

    2012-03-01

    With the aim of accurately assessing the effects of radiation exposure in the Japanese atomic-bomb survivors, the Radiation Effects Research Foundation has, over several decades, conducted studies of the Life Span Study (LSS) cohort, comprising 93 000 atomic-bomb survivors and 27 000 controls. Solid cancer: the recent report on solid cancer incidence found that at age 70 years following exposure at age 30 years, solid cancer rates increase by about 35%  Gy(-1) for men and 58% Gy(-1) for women. Age-at-exposure is an important risk modifier. In the case of lung cancer, cigarette smoking has been found to be an important risk modifier. Radiation has similar effects on first-primary and second-primary cancer risks. Finally, radiation-associated increases in cancer rates appear to persist throughout life. Leukaemia: the recent report on leukaemia mortality suggests that radiation effects on leukaemia mortality persisted for more than 50 years. Moreover, significant dose-response for myelodysplastic syndrome was observed in Nagasaki LSS members even 40-60 years after radiation exposure. Future perspective: given the continuing solid cancer increase in the survivor population, the LSS will likely continue to provide important new information on radiation exposure and solid cancer risks for another 15-20 years, especially for those exposed at a young age.

  4. Genetic radiation effects of Hiroshima and Nagasaki atomic bombs

    Energy Technology Data Exchange (ETDEWEB)

    Srsen, S. (Komenskeho Univ., Bratislava (Czechoslovakia). Lekarska Fakulta)

    1984-05-01

    A group of researchers examined persons who had survived the Hiroshima and Nagasaki bombs and were irradiated and their progeny with the aim of getting an idea of the genetic effects of these explosions. Teratogenic effects are not discussed. In the lymphocytes of the peripheral blood of persons who had been exposed to high dose irradiation the researchers found a significant increase in chromosomal aberrations by conventional and more recent methods of chromosomal analysis. In parents who had survived the atomic holocaust there were no significant deviations as against the rest of the population in still births, neonatal defects, infant mortality, and mortality of first generation progeny, in neonate weight, the sex ratio, increased occurence of leukosis and chromosomal aberrations in their children. These negative findings in the first generation do not signify that there is no danger from atomic bomb blasts for human kind. They only indicate that the effects of radiation were too small to be found by routine methods or that the methods used were not suitable.

  5. Activation of cobalt by neutrons from the Hiroshima bomb

    International Nuclear Information System (INIS)

    Kerr, G.D.; Dyer, F.F.; Emery, J.F.; Pace, J.V. III; Brodzinski, R.L.; Marcum, J.

    1990-02-01

    A study has been completed of cobalt activation in samples from two new locations in Hiroshima. The samples consisted of a piece of steel from a bridge located at a distance of about 1300 m from the hypocenter and pieces of both steel and concrete from a building located at approximately 700 m. The concrete was analyzed to obtain information needed to calculate the cobalt activation in the two steel samples. Close agreement was found between calculated and measured values for cobalt activation of the steel sample from the building at 700 m. It was found, however, that the measured values for the bridge sample at 1300 m were approximately twice the calculated values. Thus, the new results confirm the existence of a systematic error in the transport calculations for neutrons from the Hiroshima bomb. 52 refs., 32 figs., 16 tabs

  6. Mental health conditions in Korean atomic bomb survivors. A survey in Seoul

    International Nuclear Information System (INIS)

    Koshimoto, Rika; Nakane, Hideyuki; Kim, Hyen

    2011-01-01

    More than 60 years have elapsed since the atomic bombings to Hiroshima and Nagasaki, and since all of the atomic bomb survivors have become old, the importance of caring their mental health has become increasing in Japan. Although approximately 70% of overseas atomic bomb are living in Korea, there have been quite few studies on their mental health. The objectives of the present study were to elucidate whether the mental health conditions of atomic bomb survivor in Korea are similar to those in Japan. The subjects were 181 Korean atomic bomb survivors living in Korea (cases) and 209 outpatients of a hospital in Seoul who were not exposed to atomic bombs (controls). Interviewers administered them at the hospital a questionnaire with Impact of Event Scale-Revised, General Health Questionnaire 12 (GHQ-12), Korean version of short form Geriatric Depression Scale and the K scale of the Minnesota Multiphasic Personality Inventory. Excluding subjects with incomplete responses we analyzed 162 cases and 189 controls. The proportion of subjects with high score of GHQ-12 (≥4) was significantly higher in cases (78/162 or 48.1%) than in controls (42/189 or 22.2%) (p<0.0001, Fisher's exact test). The present results, though preliminary, indicate that atomic bomb survivors in Korea have also mental health problems similar to those observed in Japanese atomic bomb survivors, indicating the necessity of a larger study. (author)

  7. Proliferative and nonproliferative breast disease in atomic-bomb survivors

    International Nuclear Information System (INIS)

    Tokunaga, Masayoshi; Land, C.E.; Aoki, Yoichiro; Yamamoto, Tsutomu; Asano, Masahide; Sato, Eiichi; Tokuoka, Shoji; Sakamoto, Goi; Page, D.L.

    1993-10-01

    The risk of female breast cancer in association with radiation exposure is well established, on the basis of follow-up studies of the atomic-bomb survivors and other exposed populations. This association is especially strong for women exposed before age 20 yr and appears to be much weaker among women exposed after age 40 yr. In this study, breast-tissue autopsy samples from high-dose and low-dose individuals in the Radiation Effects Research Foundation Life Span Study sample were examined in detail to determine whether nonproliferative or proliferative breast lesions are associated with radiation exposure. The results suggest that proliferative disease in general and atypical hyperplasia in particular are associated with radiation exposure and that the risk is strongest for subjects who were ages 40-49 yr at the time of the bombings. It is hypothesized that this finding may be related to the age dependence of radiation-induced breast cancer, in the sense that potential cancers reflecting early-stage changes induced at these ages by radiation exposure may receive too little hormonal promotion to progress to frank cancers. (author)

  8. High-Energy Neutrons from the Sandstone Nuclear Bombs as Measured by Threshold Detectors

    National Research Council Canada - National Science Library

    Linenberger, G

    1949-01-01

    .... All measurements were made without collimation. The results indicate that the efficiency of a bomb cannot be determined by observing the number of neutrons above three million electron volts energy, but that the tonnage may possibly...

  9. Studies on the life spans of atom-bomb survivors

    International Nuclear Information System (INIS)

    Kato, Hiroo

    1975-01-01

    A shortening of whole life as late injuries of atom-bomb survivors was discussed from the aspects of aging and the studies on the causes of leukemia and cancers. Twenty-one thousands four hundreds and forty-seven of 109000 subjects died during the period between 1950 and 1970. Mortality by exposure doses presented a high value with exposure doses. Mortality of subjects which had received exposure doses of more than 200 rads rose to a level which was 1.27 times in all causes of deaths of the control which had received exposure doses of 0 to 9 rads, and it showed 1.32 times in all deaths of sickness, 18.3 times in leukemia, and 1.48 times in death from cancer. Mortality due to leukemia decreases after 1950-1954, but in the group which had received exposure doses over 100 rads, the mortality was significantly higher than that in all districts in Japan. The shape of dose-reaction curve in Hiroshima was different from that in Nagasaki. In the same dose, mortality due to leukemia in Hiroshima was higher than that in Nagasaki. The younger the age at exposure was, the higher the risk rate of occurring cancer was. Especially, the risk rate of cancer was high in the patients who were exposed to atomic bomb during the age of 0 to 9 years old. Mortality due to cancer increased with the dose. Cancers which statistically showed higher mortality than that in the control group are lung cancer, cancer of the breast (100-199 rad), carcinoma of the esophagus, cancer of the urinary organ (200-299 rad) and gastric cancer (over 300 rads). There are not so clear difference in the mortality due to cancer between Hiroshima and Nagasaki, comparing with the mortality due to leukemia. (Kanao, N.)

  10. Leukemia, malignant lymphoma and multiple myeloma in atomic bomb survivors treated in this hospital lately

    International Nuclear Information System (INIS)

    Niimi, Masanobu; Orimen, Akio; Ota, Takanori; Aisaka, Tadakazu

    1976-01-01

    This paper describes atomic bomb survivors with leukemia and various leukemia like diseases in Hiroshima City Funairi Hospital. The patients who had been exposed near the bombed area (1 - 3.4 km) consisted of 3 with leukemia, 4 with malignant lymphoma and 2 with multiple myeloma. These diseases seems to tend to be still increased now in the survivors exposed near the bombed area. (Serizawa, K.)

  11. Effects of radiation on the incidence of prostate cancer among Nagasaki atomic bomb survivors.

    Science.gov (United States)

    Kondo, Hisayoshi; Soda, Midori; Mine, Mariko; Yokota, Kenichi

    2013-10-01

    Atomic bomb survivors have been reported to have an increased risk of some cancers, especially leukemia. However, the risk of prostate cancer in atomic bomb survivors is not known to have been examined previously. This study examined the association between atomic bomb radiation and the incidence of prostate cancer among male Nagasaki atomic bomb survivors. The subjects were classified by distance from the hypocenter into a proximal group (<2 km), a distal group (≥2 km), and an early entrance group (those who entered the region <2 km from the hypocenter within 2 weeks after the explosion). Between 1996 and 2009, 631 new cases of prostate cancer were identified among approximately 18 400 male Nagasaki atomic bomb survivors who were alive in 1996. The Cox proportional hazard model was used to estimate the risk of prostate cancer development, with adjustment for age at atomic bomb explosion, attained age, smoking status, and alcohol consumption. Compared with the distal group, the proximal group had significant increased risks of total, localized, and high-grade prostate cancer (relative risk and 95% confidence interval: 1.51 [1.21-1.89]; 1.80 [1.26-2.57]; and 1.88 [1.20-2.94], respectively). This report is the first known to reveal a significant relationship between atomic bomb radiation and prostate cancer. © 2013 Japanese Cancer Association.

  12. Atomic-resolution neutron holography

    International Nuclear Information System (INIS)

    Cser, L.; Toeroek, Gy.; Krexner, G.

    2001-01-01

    Atomic-resolution neutron holography can be realised by two different schemes. In the frame of the first approach a point-like source of slow neutrons is produced inside the investigated crystal. Due to the extremely large value of the incoherent-scattering cross-section of the proton, hydrogen atoms imbedded in a metal single-crystal lattice may serve as point-like sources when the sample is irradiated by a monochromatic beam of slow neutrons. The second approach utilizes the registration of the interference between the incident and scattered waves by means of a point-like detector inserted in the lattice of the crystal under investigation. In addition, neutron-induced electron holography is considered. The feasibility of these ideas is discussed. (orig.)

  13. Electromagnetic neutron-atom interactions

    International Nuclear Information System (INIS)

    Sears, V.F.

    1986-01-01

    In the collision of a neutron with an atom there exists, in addition to the strong interaction with the nucleus and the magnetic dipole interaction with the magnetic electrons, a number of secondary electromagnetic interactions. The latter interactions include the spin-orbit (or Schwinger) interaction, the Foldy interaction, the nuclear magnetic dipole interaction, and interactions arising from the electric polarizability and the finite intrinsic charge radius of the neutron. We present in this paper a comprehensive review of the electromagnetic neutron-atom interactions with particular emphasis on the question of the extent to which the secondary interactions are already included implicitly in the scattering lengths obtained from accurate neutron optical measurements, which one finds listed in data tables, and the conditions under which explicit corrections for the residual secondary interactions are required in the analysis of neutron diffraction and inelastic scattering data for condensed matter. The main conclusion is that, except for the lightest atoms, the current habit of neglecting the secondary interactions can lead to significant systematic errors of up to 2 to 3% in neutron scattering experiments which extend over a wide range of momentum transfers. (orig.)

  14. Colorectal cancer among atomic bomb survivors in Hiroshima and Nagasaki, 1950-80

    International Nuclear Information System (INIS)

    Nakatsuka, Hirofumi; Yamamoto, Tsutomu; Shimizu, Yukiko

    1984-01-01

    Of 108,739 atomic-bomb (A-bomb) victims enrolled in the population of life span survey by Radiation Effects Research Foundation, 730 victims from October 1950 to December 1980 were selected as subjects of colorectal cancer based on death certificates, autopsy and operative findings, and clinicopathological reconfirmation of colorectal cancer. Tentative dose decided in 1965 (T65D) was used to estimate radiation doses of A-bomb victims. Although the incidence of colon cancer was found to be related to radiation, the relation of the incidence of rectal cancer to radiation was not confirmed. Radiation effects were dependent on the age of A-bomb victims at the time of the bombing, which was noted in A-bomb victims aged less than twenty years at that time. Dose-response relationship was found in cases of cancer of the sigmoid colon. Histological types of cancer were independent of radiation doses. (Namekawa, K.)

  15. Ionizing radiation and kidney cancer among Japanese atomic bomb survivors.

    Science.gov (United States)

    Richardson, David B; Hamra, Ghassan

    2010-06-01

    Understanding of the role of radiation as a cause of kidney cancer remains limited. The most common types of kidney cancer are renal cell carcinoma and renal pelvis carcinoma. It has been posited that these entities differ in their degree of radiogenicity. Recent analyses of cancer incidence and mortality in the Life Span Study (LSS) of Japanese atomic bomb survivors have examined associations between ionizing radiation and renal cell carcinoma, but these analyses have not reported results for cancer of the renal pelvis and ureters. This paper reports the results of analyses of kidney cancer incidence during the period 1958-1998 among 105,427 atomic bomb survivors. Poisson regression methods were used to derive estimates of associations between radiation dose (in sievert, Sv) and cancer of the renal parenchyma (n = 167), and cancer of the renal pelvis and ureter (n = 80). Heterogeneity by cancer site was tested by joint modeling of cancer risks. Radiation dose was positively associated with cancers of the renal pelvis and ureter [excess relative rate (ERR)/Sv = 1.65; 90% confidence interval (CI): 0.37, 3.78]. The magnitude of this association was larger than the estimated association between radiation dose and cancer of the renal parenchyma (ERR/Sv = 0.27; 90% CI = -0.19, 0.98). While the association between radiation and cancer of the renal parenchyma was of greater magnitude at ages populations examine these sites in aggregate, results were also derived for the combined category of cancer of the renal parenchyma, renal pelvis and ureters. Overall, there was a positive association between radiation and the combined category of cancer of the renal parenchyma, renal pelvis and ureters (ERR/Sv = 0.60, 90% CI: 0.09, 1.30). Updated follow-up of the LSS cohort provides substantial additional information on the association between radiation and cancer of the renal pelvis and ureter, a site not examined in recent reports on analyses of these data. The results are

  16. Incidence of skin cancer among Nagasaki atomic bomb survivors; Preliminary report

    Energy Technology Data Exchange (ETDEWEB)

    Sadamori, Naoki; Mine, Mariko; Hori, Makoto (Nagasaki Univ. (Japan). School of Medicine) (and others)

    1990-09-01

    Among a total of 65,268 Nagasaki atomic bomb survivors recorded in the Scientific Data Center of Atomic Bomb Disaster, Nagasaki University School of Medicine, 140 cases with skin cancer were collected from 31 hospitals in Nagasaki City from 1961 through 1987. Subsequently, these cases of skin cancer in Nagasaki atomic bomb survivors were statistically analyzed in relation to the estimated distance from the hypocenter by age, sex, histology and latent period. The results were as follows: (1) A high correlation was observed between the incidence of skin cancer and the distance from the hypocenter. (2) The incidence of skin cancer in Nagasaki atomic bomb survivors now appears to be increasing in relation to exposure distance. (3) Among 140 cases, basal cell epithelioma was observed in 67 cases (47.9%) and squamous cell carcinoma in 43 cases (30.7%). (author).

  17. Outline of developing projects of atomic bomb in Japan and USA

    International Nuclear Information System (INIS)

    Fukui, Shuji

    2007-01-01

    The content of the title connecting with the World War II is described hoping that younger researchers of nuclear physics could know some of the facts that scientists and the military of Japan and USA, respectively, had have developing projects of atomic bomb by fission reaction, although there are no official documents of those in Japan, even if there are some unofficial documents that are uncertain partly in Japan. Described are a chronological table, the content of research and development of atomic bombs, Japan's experiments by Kikuchi Laboratory of Osaka Imperial University and Nishina Laboratory of RIKEN, as well as the USA's action such as production of fissile nuclide, Pu-239 and U-235, selection of the site to fabricate atomic bomb, investigation the state of research and development of atomic bombs in Germany, Italy and Japan. (S.Y.)

  18. Study of skin cancer incidence in Nagasaki atomic bomb survivors, 1958-85

    International Nuclear Information System (INIS)

    Sadamori, Naoki; Otake, Masanori; Honda, Takeo.

    1993-03-01

    The effects of exposure to ionizing radiation on skin cancer incidence in a cohort of atomic bomb (A-bomb) survivors in the Nagasaki Extended Life Span Study (LSS-E85) sample have been investigated. Among 25,942 exposed survivors at risk whose DS86 dose estimates were available, 47 cases of skin cancer including malignant melanoma were confirmed in the Nagasaki Tumor Registry during the period from 1 April 1958 to 31 December 1985. The dose-response relationship of skin cancer based on an additive relative risk model showed linearity without threshold, not a linear-quadratic curve. The excess relative risk (ERR) of 2.2 per gray in the LSS-E85 sample was highly significant (95% confidence limits: 0.5 to 5.0). In addition, the ERR of 3.1 per gray in the Adult Health Study (AHS) sample was also significant (95% confidence limits: 0.6 to 20.3). When dose equivalents based on a relative biological effectiveness of neutrons of 10 were used, the ERR in the former sample decreased to 2.0 per sievert (95% confidence limits: 0.7-4.5), and the risk in the latter group also declined, to 2.7 per sievert (95% confidence limits: 0.6-17.8). The ERRs did not differ significantly between males and females in the LSS-E85 and AHS samples, but a highly significant increase was observed for the ERR of age at exposure and time trend since exposure. The ERR of skin cancer cases including and excluding 4 malignant melanoma cases for the LSS-E85 sample (there were no malignant melanoma cases in the AHS sample) showed almost the same linear dose response. This is the first report to demonstrate a highly significant dose-response relationship between A-bomb exposure and skin cancer incidence. (author)

  19. Temporal analysis of a dose-response relationship: leukemia mortality in atomic bomb survivors.

    Science.gov (United States)

    Brodsky, J B; Groer, P G; Liddell, R; Ishimaru, T; Ichimaru, M

    1984-09-01

    A data analysis that incorporates time dependencies is demonstrated for the dose response of leukemia mortality in the atomic bomb survivors. The time dependencies are initially left unspecified and the data on leukemia mortality--up to the end of 1978--are used to infer them. Several findings based on T65 revised doses (T65DR) are obtained. First, it is shown that the fits to the data of time-dependent L (linear in gamma dose)-Q (quadratic in gamma dose)-L (linear in neutron dose), L-L, and Q-L dose-response models are significantly improved (P less than 0.001) by using the corresponding time-dependent dose-response models. Second, it is shown that the increased risk of leukemia mortality due to gamma irradiation decreases in time while the increased risk due to neutron exposure decreases more slowly, if at all, in time. Consequently, relative biological effectiveness (RBE) of neutrons is shown to increase in time (P = 0.002) and the current definition of RBE as a time-independent quantity is therefore challenged. It is demonstrated with time-dependent models that the L-L model has a poor fit (P = 0.01) to the data for the first 7 years of study, but has an adequate fit for the remaining 21 years. In contrast the Q-L model has an adequate fit for the entire follow-up period (P greater than 0.30).

  20. Medical Database for the Atomic-Bomb Survivors at Nagasaki University

    OpenAIRE

    Mori, Hiroyuki; Mine, Mariko; Kondo, Hisayoshi; Okumura, Yutaka

    1992-01-01

    The Scientific Data Center for Atomic-Bomb Disasters at Nagasaki University was established in 1974. The database of atomicbomb survivors has been in operation since 1977. The database is composed of following 6 physical database : (1) Fundamental information database. (2) Atomic-Bomb Hospital database, (3) Pathological database, (4) Household reconstruction database, (5) Second generation database, and (6) Address database. We review the current contents of the database for its further appli...

  1. Smoking and serum proteins in atomic bomb survivors in Hiroshima

    International Nuclear Information System (INIS)

    Stram, D.O.; Akiba, Suminori; Neriishi, Kazuo; Hosoda, Yutaka; Stevens, R.G.

    1989-09-01

    Associations of smoking habit with serum levels of total protein as well as protein fractions were studied in a population consisting of 4,739 atomic bomb survivors and unexposed control subjects in Hiroshima who participated in the 1979-81 period of the Adult Health Study, an on-going health follow-up program of the RERF. Smoking was strongly related to serum protein concentration after correction for age, sex, and body mass index. Among current smokers as compared to nonsmokers, levels of total protein, β globulin, and γ globulin were significantly lower (p 1 and α 2 globulin were significantly higher (p 1 globulin. Duration of smoking (years) was related to increased α 1 and α 2 globulin. Smoking duration was also associated with albumin level but the trend was not monotonic. The radiation exposure effect on serum protein level was significant in several instances but was in general much smaller than the smoking effect. Its inclusion in the regression models did not noticeably affect the association between smoking and serum proteins. (author)

  2. Autoantibodies and immunoglobulins among atomic-bomb survivors

    International Nuclear Information System (INIS)

    Fujiwara, Saeko; Carter, R.L.; Akiyama, Mitoshi

    1993-06-01

    The purpose of this study was to determine if exposure to atomic-bomb radiation affects immune responsiveness, such as the occurrence of autoantibodies and levels of immunoglobulins. Rheumatoid factor, antinuclear antibody, antithyroglobulin antibody, anti-thyroid-microsomal antibody, and immunoglobulin levels (IgG, IgM, IgA, and IgE) were measured among 2061 Adult Health Study participants in Hiroshima and Nagasaki from December 1987 to November 1989. The prevalence and titers of rheumatoid factor increased in a statistically significant manner with increasing radiation dose. No radiation effect was found on the prevalence of antinuclear antibody, antithyroglobulin antibody, and anti-thyroid-microsomal antibody. A statistically significant relationship was also found between radiation exposure and the IgA level in females and the IgM levels in both sexes-both levels increased as radiation dose increased. However, the effects of radiation exposure were not large and accounted for less than 10% of the total variation in each measurement. Levels of IgG and IgE were not affected by radiation exposure. (author)

  3. Genetic effects of the atomic bombs: a reappraisal

    International Nuclear Information System (INIS)

    Schull, W.J.; Otake, M.; Neel, J.V.

    1981-01-01

    Data are presented on four indicators of genetic effects from studies of children born to survivors of the atomic bombings of Hiroshima and Nagasaki. The indicators are frequency of untoward pregnancy outcomes (stillbirth, major congenital defect, death during the first postnatal weak); occurrence of death in live-born children, through an average of life expectancy of 17 years; frequency of children with sex chromosome aneuploidy; and frequency of children with mutation resulting in an eletrophoretic variant. In no instance is there a statistically significant effect of parental exposure; but for all indicators the observed effect is in the direction suggested by the hypothesis that genetic damage resulted from the exposure. On the basis of assumptions concerning the contribution that spontaneous mutation in the preceding generation makes to the indicators in question, it is possible to estimate the genetic doubling dose for radiation for the first three indicators (the data base is still too small for the fourth). The average of these estimates is 156 rems. This is some four times higher than the results from experimental studies on the mouse with comparable radiation sources, which have been the principal guide to the presumed human sensitivities. The relevance of these data in setting permissible limits for human exposures is discussed briefly

  4. Genetic effects of the atomic bombs: a reappraisal

    International Nuclear Information System (INIS)

    Schull, W.J.; Otake, M.; Neel, J.V.

    1981-01-01

    Data are presented on four indicators of genetic effects from studies of children born to survivors of the atomic bombings of Hiroshima and Negasaki. The indicators are frequency of un toward pregnancy outcomes (stillbirth, major congenital defect, death during first postnatal week); occurrence of death in live-born children, through an average life expectancy of 17 years; frequency of children with sex chromosome aneuploidy; and frequency of children with mutation resulting in an electrophoretic variant. In no instance is there a statistically significant effect of parental exposure; but for all indicators the observed effect is in the direction suggested by the hypothesis that genetic damage resulted from the exposure. On the basis of assumptions concerning the contribution that spontaneous mutation in the preceding generation makes to the indicators in question, it is possible to estimate the genetic doubling dose for radiation for the first three indicators (the data base is still too small for the fourth). The average of these estimates is 156 rems. This is some four times higher than the results from experimental studies on the mouse with comparable radiation sources, which have been the principal guide to the presumed human sensitivities. The relevance of these data in setting permissible limits for human exposures is discussed briefly

  5. Mortality among atomic-bomb survivors, 1950-1990

    International Nuclear Information System (INIS)

    Preston, D.L.; Mabuchi, Kiyohiko; Pierce, D.A.

    1997-01-01

    A comprehensive analysis of cancer mortality in the Life Span Study (LSS) cohort of atomic bomb survivors during the period from 1950 through 1990 was recently published in Radiation Research. Work is also nearing completion on an updated analysis of data on noncancer mortality in the LSS. The new LSS mortality reports, collectively called Report 12, differ from earlier LSS reports in several general aspects. The Report includes some simple tabular, and graphical summaries of the excess risks which were developed to make it easier to comprehend the magnitude and nature of the excess risks in this cohort while highlighting uncertainties in the current LSS data. In order to overcome problems inherent in the use of summary risk estimates averaged over the current follow-up, sex- and age-at-exposure-specific lifetime risks computed for the LSS cohort are used as primary summaries of the excess risks. Throughout the new report, risk estimates were derived from models that make explicit allowance for important risk-modifying factors, such as age-at-exposure, sex, or attained age. This chapter contains a brief summary of some of the findings of the cancer mortality report and provides a preview of the latest non-cancer results

  6. Ophthalmologic survey of atomic bomb survivors in Japan, 1949. Atomic bomb radiation cataract case report with histopathologic study. Medical examination of Hiroshima patients with radiation cataracts

    Energy Technology Data Exchange (ETDEWEB)

    Cogan, D.G.; Martin, S.F.; Kimura, S.J.; Ikui, Hiroshi; Fillmore, P.G.

    1959-01-01

    This document contains 3 reports dealing with the delayed effects of radiation on the eyes of survivors of the atomic explosions in Hiroshima and Nagasaki. In the first study, 1000 persons who were listed as having been in the open and within two kilometers of the hypocenter at the time of the explosion were selected at random from the census files of the Atomic Bomb Casualty Commission for study. In addition, 231 others, comprising the total available number of surviving persons listed at present in the census files as having been within one kilometer of the hypocenter, were examined, as were several hundred others who were contacted through newspaper publicity, referrals from local ophthalmologists, or through hearsay. The survey resulted in bringing in persons having, or having had, a variety of ocular conditions. Those connected with the atomic bomb included the following diagnoses; multiple injuries of eyes and eyelids; keratoconjunctivitis from ultraviolet and ionizing radiations; thermal burn of the cornea and of the retina; retinitis proliferans; and radiation cataracts. The cataracts were the only delayed manifestations of ocular injury from the atomic bomb. The second paper is a case report of a histopathologic study of atomic bomb radiation cataract. The third paper presents the results of medical examinations of survivors having radiation induced cataracts. 32 references, 8 figures. (DMC)

  7. Some hematological disorders among atomic bomb survivors. Presidential Address

    International Nuclear Information System (INIS)

    Watanabe, Susumu

    1977-01-01

    Focusing on their hematological disorders, the late radiation effects among Hiroshima and Nagasaki A-bomb survivors, including cytogenetic and cytological studies, are summarized and discussed. Because of personal research experience, the data were concentrated on the Hiroshima survivors

  8. Proteinuria in Hiroshima and Nagasaki atomic bomb survivors

    Energy Technology Data Exchange (ETDEWEB)

    Freedman, L.R.; Seki, Masafumi; Phair, J.P.; Nefzger, M.D.

    1966-08-25

    A study of the epidemiology of proteinuria was conducted on about 5000 persons comprising a portion of the clinical sample under study at the Atomic Bomb Casualty Commission. In addition, data from previous examinations of similar samples were analyzed. Proteinuria was more common in Hiroshima than in Nagasaki. The rates for men and women did not differ within cities. Age-specific rates of proteinuria were peculiar, peaking in adolescence and old age. In the subjects under study proteinuria was frequently inconstant and usually represented excretion of less than 1.0 g of protein per day. Prior exposure to radiation as measured by distance from the hypocenter was correlated with increased proteinuria rates in 18-year-old subjects who were in utero ATB. Subjects exposed after birth did not show this tendency. It is unsettled whether radiation results in renal disease by increasing the subject's susceptibility to the usual causes of glomerulonephritis or by some more direct mechanism. Persons with proteinuria had higher mean blood pressures and serum urea nitrogen levels than controls and had other findings indicative of generalized cardiovascular-renal disease. Persons with thyroid disease had an increased risk of proteinuria whereas the converse was true of those with a history of treatment for peptic ulcer. Many other factors were tested for a relation to proteinuria, including family history of renal disease, socioeconomic status, urinary symptoms, ingestion of medications, physical findings, hemoglobin levels, height, weight, ABO blood groups, audiometry, vibrometry, and serum cholesterol levels. Although urinary symptoms were more common in persons with proteinuria, the findings in other areas were not sufficiently different to suggest meaningful relations. 20 references, 2 figures, 13 tables.

  9. Whole-blood phagocytic and bactericidal activities of atomic bomb survivors, Hiroshima and Nagasaki

    International Nuclear Information System (INIS)

    Sasagawa, Sumiko; Yoshimoto, Yasuhiko; Toyota, Emiko; Neriishi, Shotaro; Yamakido, Michio; Matsuo, Miyo; Hosoda, Yutaka; Finch, S.C.

    1989-04-01

    This in vitro study evaluated the phagocytic and bactericidal activities of leukocytes in aliquots of whole blood from Hiroshima and Nagasaki atomic bomb survivors for Staphylococcus aureus. The data were analyzed by multiple linear regression. Any significant effects of exposure to A-bomb radiation could not be detected for both phagocytic and bactericidal activities of whole blood from A-bomb survivors. In addition, there were no significant effects of age categories, sex or city, except in neutrophil counts. (J.P.N.)

  10. Seeing the Light: Visibility of the July '45 Trinity Atomic Bomb Test from the Inner Solar System

    Science.gov (United States)

    Reed, B. Cameron

    2006-01-01

    In his "The Making of the Atomic Bomb," Richard Rhodes remarks of the July 16, 1945, Trinity atomic bomb test in New Mexico that "had astronomers been watching they could have seen it reflected from the moon, literal moonshine," an allusion to Ernest Rutherford's famous dismissal of the prospect of atomic energy. Investigating…

  11. Study of thyroid tumors in atomic bomb survivors in Nagasaki

    International Nuclear Information System (INIS)

    Sekine, Ichiro; Shichijo, Kazuko; Ito, Masahiro; Kishikawa, Masao; Mine, Mariko; Ikeda, Takayoshi; Ooya, Seiichi.

    1992-01-01

    Thyroid tumors, which were registered during 16 years from 1973 through 1988 in the Nagasaki tumor tissue registration committee, were examined with the purpose of searching for the relationship between thyroid tumors and A-bombing. One hundred and three A-bomb survivors having an A-bomb survivors 'handbook and 89 non-exposed persons born before August 9, 1945 in Nagasaki City were enrolled in the present study. The A-bomb survivors were divided into three groups: people exposed at >2,000 m from the hypocenter (n=20), those exposed at ≤2,000 m (n=68), and those entered the city early after A-bombing (n=15). Thyroid tumors examined were: thyroid carcinoma, nodular goiter, thyroid adenoma and malignant lymphoma. Crude incidence rate and relative risk of thyroid cancer were higher in all exposed groups, except for the ≤2,000 m group of males, than the non-exposed group. In particular, the >2,000 m group had significantly higher incidence of thyroid cancer, irrespective of sex. These findings confirmed the previous data for the higher incidence of thyroid cancer in A-bomb survivors exposed to higher doses of radiation. According to age, thyroid cancer was the most common in their sixth decade of life in the exposed group and in their fifth decade of life in the non-exposed group. Histologically, follicular carcinoma occupied higher incidence in the exposed group (19.2%) than the non-exposed group (8.7%). (N.K.)

  12. Mortality statistics among atomic bomb survivors in Hiroshima Prefecture. 1968-1972

    Energy Technology Data Exchange (ETDEWEB)

    Kurihara, M.; Munaka, M.; Hayakawa, N.; Yamamoto, H.; Ueoka, H.; Ohtaki, M. (Hiroshima Univ. (Japan). Research Inst. for Nuclear Medicine and Biology)

    1981-12-01

    In a comparative analysis of mortality among atomic bomb survivors versus the non-exposed, both resident in Hiroshima Prefecture, it was found that in addition to leukaemia, malignant lymphoma, multiple myeloma, and cancers of the thyroid gland, breast, lung, esophagus, stomach, urinary organs and salivary gland which have been reported from the past to be elevated in risk among atomic bomb survivors, cancers of the colon, larynx, accessory sinuses, uterus, ovary and testis, diseases of the blood, cirrhosis of liver, hypertensive disease and diabetes mellitus were elevated in risk, but the risk of cerebrovascular disease, heart disease, peptic ulcer, gastroenteritis, senility, and accidents was lower than the non-exposed. The relationship of atomic bomb exposure to the relative risk of cancers of the lung, breast, uterus, and testis could be readily explained, but the relationship between atomic bomb exposure and the relative risk of cancers of many other sites, diseases of the blood, and other causes of death was inconsistent. One of the reasons why the risk of senility was low and the risk of diseases of the blood, malignant neoplasms, diabetes mellitus, and hypertensive disease was high is considered to be the higher diagnostic accuracy in atomic bomb survivors.

  13. Studies on population change of atomic bomb survivors in Hiroshima prefecture 1965-1979

    International Nuclear Information System (INIS)

    Ueoka, Hiroshi; Munaka, Masaki; Kurihara, Minoru

    1984-01-01

    Studies of population change of Japanese Atomic Bomb Survivors from 1965 to 1979 in Hiroshima prefecture of which registered in Data Base of Atomic Bomb Survivors of RINMB were conducted, and following were obtained: 1. Population change of Japanese Atomic Bomb Survivors showed increasing trend until 1976 and diminishing trend from 1977. It would be estimated that reason of increasing trend of Atomic Bomb Survivors was correlated the same trend to get register card of ''Atomic Bomb Treatment Law'', and decreasing trend of them was related so much death of the elderly generations. 2. Analysing by residential place the survivors who make a living in Hiroshima city was almost 110,000, and those who make a living in Hiroshima prefecture (except Hiroshima city) was 65,000. Considering exposed distance of the survivors in Hiroshima city, those survivors exposed within 2 km showed diminishing trend; and those who make a living in Hiroshima prefecture (except Hiroshima city), exposed within 2 km showed increasing trend. 3. In 1979, the ratio of male and female survivors by age level showed difference. Those male survivors over 50 years old in Hiroshima city showed much lower percentage than female. 4. In 1979, the population trends of survivors who get the ''card'' before 1964 showed rapid decrease, and those who get the ''card'' after 1965 showed mild decrease. (author)

  14. Why didn't Hitler get the atomic bomb

    International Nuclear Information System (INIS)

    Chevassus-au-Louis, Nicolas

    2013-01-01

    This bibliographical note presents a book in which the author reports his historical studies on the Nazi's nuclear activities as, by the end of the 1930's, Germany was probably the leader in this domain. He mentions and describes the various programs that were launched between 1939 and 1945, discusses some evidences related to the fact that the Germans probably tried to master nuclear energy production, and that they might have tested a weapon containing fissile materials (probably a dirty bomb). The author analyses the reasons of the failure of this nuclear sector: a lack of organization, war and bombings, and a relative lack of interest of political authorities

  15. The development of the atomic bomb, Los Alamos

    Energy Technology Data Exchange (ETDEWEB)

    Seidel, R.W.

    1993-11-01

    The historical presentation begins with details of the selection of Los Alamos as the site of the Army installation. Wartime efforts of the Army Corps of Engineers, and scientists to include the leader of Los Alamos, Robert Oppenheimer are presented. The layout and construction of the facilities are discussed. The monumental design requirements of the bombs are discussed, including but not limited to the utilization of the second choice implosion method of detonation, and the production of bomb-grade nuclear explosives. The paper ends with a philosophical discussion on the use of nuclear weapons.

  16. Malignant breast tumors among Atomic Bomb Survivors, Hirsoshima and Nagasaki, 1950 to 1974

    International Nuclear Information System (INIS)

    Tokunaga, M.; Norman, J.E. Jr.; Asano, M.; Tokuoka, S.; Ezaki, H.; Nishimori, I.; Tsuji, Y.

    1979-01-01

    From 1950 to 1974, 360 cases of malignant breast tumors were identified among the 63,000 females of the Radiation Effects Research Foundation's (Hiroshima and Nagasaki) Extended Life-Span Study sample of survivors of the 1945 atomic bombings of Hiroshima and Nagasaki; 288 of these females were residing in one of these two cities at the time of bombing (ATB). Two-thirds of all cases were classified as breast cancers on the basis of microscopic review of slides, and 108 cases received an estimated breast tissue dose of at least 10 rads. The number of cases of radiogenic breast cancer could be well estimated by a linear function of radiation dose for tissue doses below 200 rads. Excess risk estimates, based on this function, for women 10 to 19, 20 to 29, 30 to 39, and 50 years old or older ATB were 7.3, 4.2, 2.6, and 4.7 cases per million women per year per rad, respectively. Women irradiated in their forties showed no dose effect. Among all women who received at least 10 rads, those irradiated before age 20 years will have experienced the highest rates of breast cancer throughout their lifetimes. Separate excess risk estimates for Hiroshima and Nagasaki did not differ significantly, which indicates that for radiogenic breast cancer the effects of neutrons (emitted only in the Hiroshima explosion) and gamma radiation were about equal. Radiation did not reduce the latency period for the development of breast cancer, which was at least 10 years. The distribution of histologic types of cancers did not vary significantly with radiation dose. The data suggested that irradiation prior to menarche conferred a greater risk than irradiation after menarche

  17. Accurate dating with radiocarbon from the atom bomb tests

    CSIR Research Space (South Africa)

    Vogel, JC

    2002-09-01

    Full Text Available The artificial radiocarbon produced by the thermonuclear bomb tests in the 1950s and 1960s significantly increased the level of C-14 in the environment. A detailed record of the subsequent changes in the C-14 concentration of the atmosphere can...

  18. Leukemia among atomic bomb survivors during the 1980s

    International Nuclear Information System (INIS)

    Kusumi, Shizuyo; Matsuo, Tatsuki

    1990-01-01

    On the basis of the dosimetry system 1986, exposure doses were determined in a cohort of 86,502 subjects for the Life Span Study during the period 1950-1985. A total of 248 people were found to develop leukemia in Hiroshima and Nagasaki cities. This is an analysis of the 248 patients with leukemia in connection with exposure doses, years after A-bombing, age at the time of A-bombing, relative risk, and background. An average exposure dose was 0.20 Gy for Hiroshima and 0.22 Gy for Nagasaki. Relative risk for leukemia tended to show a linear increase in proportion to exposure doses. This was significant for acute myelocytic leukemia (AML), regardless of whether A-bomb survivors came from Hiroshima or Nagasaki. The younger the age at the time of A-bombing was, the higher excess relative risk for acute lymphocytic leukemia (ALL) and chronic myelocytic leukemia (CML) was. For AML, however, it was independent of the age at that time. These findings were similar in Hiroshima and Nagasaki A-bomb survivors, irrespective of age. As for non-exposed group, the incidence of CML was three times higher in Hiroshima citizen than Nagasaki citizen. Similarly, Hiroshima citizen had a 1.6 fold incidence of AML. There was no significant difference in the incidence of ALL between the cities. The incidences of both AML and ALL tended to increase more and more with aging, but the prevalences tended to increase in younger generation. An increased incidence of CML was associated with aging alone. (N.K.)

  19. The effect of changes in dosimetry on cancer mortality risk estimates in the atomic bomb survivors

    International Nuclear Information System (INIS)

    Preston, D.L.; Pierce, D.A.

    1987-08-01

    In the spring of 1986, RERF received a new dosimetry system which was developed by the US-Japan Committee for Reassessment of Atomic Bomb Radiation Dosimetry in Hiroshima and Nagasaki. This report presents the comparisons of leukemia and nonleukemia cancer mortality risk estimates under the old and new dosimetries. In terms of total kerma (essentially whole-body gamma-ray plus neutron exposure), the risk estimates for both types of cancer are 75 %-85 % higher with the new dosimetry. This and other summary comparisons here make some allowance for possible nonlinearity at high estimated doses. It is also important to consider the changes in relation to organ doses and assumptions about the relative biological effectiveness (RBE) of neutrons. Without regard to RBE, the risk estimates for total organ dose are essentially unchanged by the dosimetry revision. However, with increasing assumed values of RBE, the estimated low-LET risk decreases much less rapidly under the new dosimetry, due to the smaller neutron component. Thus at an assumed constant RBE of 10, for example, the effect of the dosimetry revision is to increase organ dose risk estimates, relative to those based on the old dosimetry, by 30 % for nonleukemia and 80 % for leukemia. At an RBE of 20 these increases are 72 % and 136 %, respectively. A number of other issues are discussed. The city difference in dose-response is smaller with the new dosimetry, and is no longer statistically significant, even at an RBE of one. Estimation of RBE is even less feasible with the new dosimetry. There is substantial question of the linearity in dose-response, in the sense of a leveling off at higher doses. Finally, some indication is given of how estimated lifetime risks from this dosimetry may compare to widely-used estimates based largely on the RERF data with the previous dosimetry. (author)

  20. A review of 40 years studies of Hiroshima and Nagasaki atomic bomb survivors

    International Nuclear Information System (INIS)

    Itsuzo Shigematsu

    1993-01-01

    The late health effects of ionizing radiation have been studied by the Atomic Bomb Casualty Commission (ABCC) and its successor, the Radiation Effects Research Foundation (RERF) based on a fixed population of atomic bomb survivors in Hiroshima and Nagasaki which had been established in 1950. The results thus far obtained up to the present can be classified into the following three categories: (1) The effects for which a strong association with atomic bomb radiation has been found include malignant neoplasms, cataracts, chromosomal aberrations, small head size and mental retardation among the in utero exposed. (2) A weak association has been found in the several sites of cancers, some non-cancer mortalities and immunological abnormalities. (3) No association has been observed in some types of leukemia, osteosarcoma, accelerated aging, sterility and hereditary effects

  1. A statistical study of autopsy cases in Hiroshima Atomic Bomb Hospital 1956-1975

    International Nuclear Information System (INIS)

    Hamada, Tadao; Ishida, Sadamu; Matsushita, Hiroshi.

    1976-01-01

    In order to study the differences in the incidence of a variety of disease (excluding tumors), between the cases exposed to the atomic bomb and those who were unexposed, main lesions were studied statistically by autopsy. The subjects were 1230 cases autopsied at the Hiroshima Atomic Bomb Hospital or the Hiroshima Red-Cross Hospital. They were divided into 318 cases exposed at a short distance from the bombed area (within 2 km), and 420 cases exposed at a long distance from that area (more than 2 km), including those who had come to Hiroshima later. Four hundred twenty nine unexposed cases were selected as controls. The incidence of tumor, disturbance of circulation, disturbance of the blood vessels in the brain, blood disease, and respiratory disease was higher in the exposed cases than in the unexposed cases. The incidence of cirrhosis of the liver was higher in females than in males, and was lower in cases farther from the bombed area. Cardiac infarction, valvular disease, and endocarditis were more often seen in the cases exposed near the bombed area. The incidence of the blood vessels in the brain was highest in the exposed cases near the bombed area. The incidence of disturbance of circulation, and disturbance of the blood vessels in the brain had a tendency to be higher in the exposed cases than in the unexposed cases. This is considered to be due to the advanced age in the exposed cases. (Serizawa, K.)

  2. Accident in science history. Hitler's atomic bomb; Stoerfall der Wissenschaftsgeschichte. Hitlers Atombombe

    Energy Technology Data Exchange (ETDEWEB)

    Popp, Manfred

    2016-07-01

    Up to now the historical explanation for the fact that NS Germany did not develop an atomic bomb was that there was enough scientific and technical knowledge but not enough resources. Recent historical research showed that the German scientists in the ''Uranverein'' did not know the cross section of U-235 and had no possibility to measure these cross sections. There exist only very few documents dealing with the bomb. The bomb was treated as a special case of a reactor. Obviously the German scientists did not know he bomb technology. It seems that the project was not success-oriented because the scientists expected to be sent to the front in case of a project stop.

  3. Frequency of marriage and live birth among survivors prenatally exposed to the atomic bomb

    International Nuclear Information System (INIS)

    Blot, W.J.; Shimizu, Y.; Kato, H.; Miller, R.W.

    1975-01-01

    Frequency of marriage and birth as of January 1973 was determined for persons exposed in utero to the atomic bombs in 1945 and for controls. The marriage rate was lower in persons heavily exposed in utero than in the non-exposed or lightly exposed. This difference is attributed partly to the lesser marriageability of persons with mental retardation who are significantly more numerous among the heavily exposed, and partly to unmeasured variables, possibly including social discrimination against survivors of the atomic bomb. No consistent relation was observed between radiation exposure and three reproductive indices: childless marriages, number of births, and interval between marriage and first birth

  4. A study on thyroid disorder of Sjoegren's disease in atomic bomb survivors in Hiroshima

    International Nuclear Information System (INIS)

    Noma, Koji; Sasaki, Hideo; Ito, Chikako; Hasegawa, Kazuyo.

    1984-01-01

    Thyroid disorders were seen in eight of 25 atomic bomb survivors with Sjoegren's disease -- simple goiter in 2, chronic thyroiditis in 4, and primary hypothyroidism probably arising from chronic thyroiditis in 2. Thyroid disorders associated with Sjoegren's disease seemed to occur frequently in survivors exposed near the explosion. One of the two survivors with primary hypothyroidism had been exposed to atomic bomb 1.7 km from the explosion. As for the other clinical laboratory findings, there was no significant difference between the group with thyroid disorders and the group without them. (Namekawa, K.)

  5. The relationship between the life environment of the atomic bomb survivors (Hibakusha) and their cardiovascular disorders

    International Nuclear Information System (INIS)

    Tasaka, Masatoshi; Saito, Osamu; Miyaki, Sumiyo; Watabu, Akiko

    1978-01-01

    In order to observe clinically the effects of the atomic bomb on the human body (and on the environment), subjects were divided into group A (persons living in Hiroshima city more than 10 years after dropping of the atomic bomb) and group B (persons who changed their residence within 1 month). Group A was divided into two separate groups: group A 1 (persons living in segregated areas), and group A 2 (persons living in other areas). General examinations showed no abnormal findings. Incidence of abnormal ECG findings was higher in subjects living in segregated areas and was also higher in women than in men. (Namekawa, K.)

  6. Micronuclei and chromosome aberrations found in bone marrow cells and lymphocytes form thorotrast patients and atomic bomb survivors

    Energy Technology Data Exchange (ETDEWEB)

    Tanaka, Kimio; Izumi, Takaki; Ohkita, Takeshi; Kamada, Nanao (Hiroshima Univ. (Japan). Research Inst. for Nuclear Medicine and Biology)

    1984-03-01

    As two cytogenetic parameters of radiation exposure, the frequency of micronucleus in erythroblasts, lymphocytes and red cells (Howell-Jolly body) as well as chromosome aberrations in bone marrow cells and in lymphocytes were studied in 24 thorotrast patients and in 32 atomic bomb (A-bomb) survivors who were exposed within one kilometer from the Hiroshima hypocenter. The incidence of both micronucleus and chromosome aberrations in these two exposed groups were significantly higher than that in non-exposed controls. So that these two parameters are useful guide for evaluating the residual effects of radiation, especially on hematopoietic cells. Because of its simple procedures, micronucleus test is also helpful as screening for prediction of chromosome aberrations. The characteristics of lymphocyte chromosome aberrations differed considerably between thorotrast patients and A-bomb survivors; the incidence of unstable type aberrations and intracellular complexity of chromosome aberrations were much higher in the former group. The incidence of micronucleus in erythroblasts and lymphocytes was also higher in thorotrast patients. Such differences are attributable to the differences in the radiation quality (..cap alpha..-ray or ..gamma..-ray+neutron) and in the mode of exposure (persistent or single) of these two groups.

  7. Effects of radiation on aging in atomic bomb survivors

    International Nuclear Information System (INIS)

    Okajima, Shunzo; Miyajima, Junko; Ichimaru, Michito

    1980-01-01

    Effect of radiation on aging was studied for 122 female a-bomb survivors exposed to more than 100 rad. Correlations of grades of external appearances, Physiological functions, and hematological features with age and radiation were investigated. Several parameters were used for multiple regression analysis, including hair loss, skin elasticity, grip strength, blood pressure, potassium content etc. The comparison of the estimated age of the exposed group and unexposed one showed no statistically significant difference. (Nakanishi, T.)

  8. Autopsy cases of hepatocellular carcinoma in atomic bomb survivors

    International Nuclear Information System (INIS)

    Fujihara, Megumu; Kurihara, Kanji; Aimitsu, Shiomi; Yukaya, Hirofumi; Hamada, Tadao.

    1994-01-01

    Since 1956, 388 autopsy cases of hepatocellular carcinoma (HCC) have been obtained at the Hiroshima Red Cross and A-Bomb Survivors Hospital, which consisted of those of proximately exposed 52 A-bomb survivors (mean age, 63.8 years), 105 distally exposed A-bomb survivors (mean age, 64.2 years), and the other 231 non-exposed patients (mean age, 60.6 years). Since 1985, the incidence of HCC tended to be higher in both proximately and distally exposed groups than the non-exposed group. There was no consistent tendency for the incidence of HCC by ages at autopsy and A-bombing. The incidence of liver cirrhosis was approximately 2 times higher in males than females in the non-exposed group, although no gender difference existed after 1981. In the exposed group, the incidence was similar in male and female groups. Approximately 90% of HCC patients had coexistent liver cirrhosis. Liver cirrhosis was associated with HCC in 50-60%. No significant differences in these incidences were observed between the exposed and non-exposed groups. The proportion of liver cirrhosis associated with HCC became constant in patients over the age of 40 in the non-exposed group. In the exposed group, on the other hand, the proportion reached the peak in those in their fifties and sixties. Survival time tended to be longer in the exposed group than the non-exposed group. The patients in the non-exposed group tended to have histologically atypical type and metastases, as compared with those in the exposed group. (N.K.)

  9. Cancer mortality among atomic bomb survivors exposed as children.

    Science.gov (United States)

    Goto, Hitomi; Watanabe, Tomoyuki; Miyao, Masaru; Fukuda, Hiromi; Sato, Yuzo; Oshida, Yoshiharu

    2012-05-01

    To compare cancer mortality among A-bomb survivors exposed as children with cancer mortality among an unexposed control group (the entire population of Japan, JPCG). The subjects were the Hiroshima and Nagasaki A-bomb survivor groups (0-14 years of age in 1945) reported in life span study report 12 (follow-up years were from 1950 to 1990), and a control group consisting of the JPCG. We estimated the expected number of deaths due to all causes and cancers of various causes among the exposed survivors who died in the follow-up interval, if they had died with the same mortality as the JPCG (0-14 years of age in 1945). We calculated the standardized mortality ratio (SMR) of A-bomb survivors in comparison with the JPCG. SMRs were significantly higher in exposed boys overall for all deaths, all cancers, leukemia, and liver cancer, and for exposed girls overall for all cancers, solid cancers, liver cancer, and breast cancer. In boys, SMRs were significantly higher for all deaths and liver cancer even in those exposed to very low doses, and for all cancers, solid cancers, and liver cancer in those exposed to low doses. In girls, SMRs were significantly higher for liver cancer and uterine cancer in those exposed to low doses, and for leukemia, solid cancers, stomach cancer, and breast cancer in those exposed to high doses. We calculated the SMRs for the A-bomb survivors versus JPCG in childhood and compared them with a true non-exposed group. A notable result was that SMRs in boys exposed to low doses were significantly higher for solid cancer.

  10. Hyperparathyroidism among atomic bomb survivors in Hiroshima, 1986-88

    International Nuclear Information System (INIS)

    Fujiwara, Saeko; Ezaki, Haruo; Sposto, R.; Akiba, Suminori; Neriishi, Kazuo; Kodama, Kazunori; Hosoda, Yutaka; Shimaoka, Katsutaro; Yoshimitsu, Kengo.

    1990-10-01

    During the two-year period from August 1986 to July 1988, the prevalence of hyperparathyroidism (HPT) was determined among A-bomb survivors and unexposed control subjects in Hiroshima. The diagnosis of HPT was determined biochemically, based upon the presence of consistent hypercalcemia and elevated serum parathyroid hormone levels. Among a population of 4,675 individuals (1,527 males, 3,148 females), primary HPT was diagnosed in 22 (3 males, 19 females). Of these, 8 underwent surgery, of whom 6 had a single parathyroid adenoma and 2 had parathyroid hyperplasia. HPT was more prevalent among the A-bomb survivors who received higher radiation doses (p <.001 for linear trend). The prevalence rates predicted from the model were 0.204% (±0.094%) at 0 Gy and 0.893% (±0.237%) at 1 Gy. The background rate of HPT did not differ significantly by sex or by age at the time of the bombing, although the effect of radiation exposure was greater for individuals exposed at a younger age (p <.01). (author)

  11. The Atomic Fingerprint: Neutron Activation Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Keisch, Bernard [Carnegie-Mellon University

    1972-01-01

    The nuclei of atoms are stable only when they contain certain numbers of neutrons and protons. Since nuclei can absorb additional neutrons, which in many cases results in the conversion of a stable nucleus to a radioactive one, neutron activation analysis is possible.

  12. Congenital malformations, stillbirths, and early mortality among the children of atomic bomb survivors: A reanalysis

    International Nuclear Information System (INIS)

    Otake, M.; Schull, W.J.; Neel, J.V.

    1990-01-01

    Of all the data sets pertinent to the estimation of the genetic risks to humans following exposure to ionizing radiation, potentially the most informative is that composed of the cohort of children born to atomic bomb survivors. We present here an analysis of the relationship between parental exposure history and untoward pregnancy outcomes within this cohort, using to the fullest extent possible the recently revised estimates of the doses received by their parents, the so-called DS86 doses. Available for study are 70,073 terminations, but DS86 doses have not been or presently cannot be computed on the parents of 14,770. The frequency of untoward pregnancy outcomes, defined as a pregnancy terminating in a child with a major congenital malformation, and/or stillborn, and/or dying in the first 14 days of life, increases with combined (summed) parental dose, albeit not significantly so. Under a standard linear model, when the sample of observations is restricted to those children whose parents have been assigned the newly established DS86 doses (n = 55,303), ignoring concomitant sources of variation and assuming a neutron RBE of 20, the estimated increase per sievert in the predicted frequency of untoward outcomes is 0.00354 (+/- 0.00343). After adjustment for concomitant sources of variation, the estimated increase per sievert in the proportion of such births is 0.00422 (+/- 0.00342) if the neutron RBE is assumed to be 20. A one-hit model with appropriate adjustments for extraneous sources of variation results in an almost identical value, namely, 0.00412 (+/- 0.00364)

  13. Noncancer mortality based on the Hiroshima Atomic Bomb survivors registry over 30 years, 1968-1997

    Energy Technology Data Exchange (ETDEWEB)

    Kasagi, Keiko [Hiroshima Univ. (Japan). Research Inst. for Radiation Biology and Medicine

    2002-04-01

    The relation of radiation exposure with noncancer mortality was examined on 44,514 atomic bomb survivors (17,935 males, 26,579 females, and mean age 22.8{+-}15.7 yrs at the time of bombing) registered at Research Institute for Radiation Biology and Medicine, Hiroshima University, based on mortality follow-up over 30 years, 1968-1997. Noncancer mortality was significantly related to radiation dose with relative risk of 1.06 at 1 Sv radiation dose, although weaker than the dose response in solid cancer mortality. The significant dose responses were observed especially in circulatory disease, stroke and urinary organ disease, and suggestive dose response in pneumonia. The temporal pattern in dose response by age at the time of bombing indicated that the relative risk of noncancer mortality was higher with follow-up period, which is contrary to a decreasing dose response in solid cancer mortality with follow-up period. The tendency was remarkable in those survivors younger at the time of bombing. These findings suggest that the significant radiation risk observed in noncancer mortality might increase as the proportion of younger survivors among atomic bomb survivors increases. (author)

  14. The significance of chromosome deletions in atomic-bomb survivors

    International Nuclear Information System (INIS)

    Tanaka, Kimio; Shigeta, Chiharu; Oguma, Nobuo; Kamada, Nanao; Deng, Z.; Niimi, Masanobu; Aisaka, Tadaichi.

    1986-01-01

    In 39 A-bomb survivors 40 years after exposure at ≤ 1,000 m from ground zero, the frequency and features of chromosome deletions in peripheral lymphocytes were examined using a differential staining technique. Simultaneously, in vitro irradiation experiment with Cf-252 was made to infer chromosome aberrations occuring immediately after exposure. Californium-252 with 100 rad induced dicentric and ring chromosomes in 40 % of the cells and acentric fragments in 44 %. Among the A-bomb survivors, chromosome aberrations were observed in 651 (21 %) of the total 3,136 cells. There were 146 cells with deletions (22 % of abnormal cells; 5 % of the total cells), and 10 cells with acentric fragment (0.3 % of the total cells). The figure for deletions was far higher than that reported in the literature. A large number of deletions were seen in chromosomes no.4, no.21, and no.22, and a few deletions in chromosomes no.7 and no.20. Significance of chromosome deletions is discussed. (Namekawa, K.)

  15. Statistical observation on autopsy cases of malignancy at the Japanese Red Cross, Nagasaki Atomic Bomb Hospital

    International Nuclear Information System (INIS)

    Takahara, Osamu; Toyoda, Shigeki; Tsuno, Sumio; Mukai, Hideaki; Uemura, Seiji

    1976-01-01

    Statistical observation was made as to autopsy cases of atomic-bomb survivors in Nagasaki. The total of autopsy cases at the Japanese Red Cross, Nagasaki Atomic Bomb Hospital from the opening of the hospital, 1968, to December in 1975 was 1,486 cases (autopsy rate, 65.1%) in which 880 cases of atomic bomb survivors (autopsy rate, 68.0%) were contained. Cases of malignancy totaled 829 and 528 cases of those were atomic bomb survivors. Cases of malignancy were divided into three groups, that is, group exposured to atomic bomb at place within 2 km from the explosion place, group exposured at place from more than 2 km or entering after explosion into the city, and not-exposured group. Relationship between main malignancies and exposure was discussed, and the following results were obtained. 1) Obvious relationship was found to exist between exposure and acute and chronic medullary leukemia. 2) Malignant lymphoma was scarecely correlated with exposure, but its occurrence rate was higher than the mean rate in Japan in reflection the region where this disease occurs much geographically. 3) Relationship between exposure and stomach cancer, lung cancer, cancer of the large intestine, and double cancer was not found obviously, but occurrence rate of hepatic cancer was higher than the mean rate in Japan in three groups. The reason was supposed to be geographical factor. 4) Cases of thyroid gland cancer were a small number in female of the group exposured within 2 km, and cases of prostate cancer were a small number in the group within 2 km, but their occurrence rate was high specifically. (Tsunoda, M.)

  16. Workshop Report on Atomic Bomb Dosimetry--Residual Radiation Exposure: Recent Research and Suggestions for Future Studies

    Energy Technology Data Exchange (ETDEWEB)

    None

    2013-06-06

    There is a need for accurate dosimetry for studies of health effects in the Japanese atomic bomb survivors because of the important role that these studies play in worldwide radiation protection standards. International experts have developed dosimetry systems, such as the Dosimetry System 2002 (DS02), which assess the initial radiation exposure to gamma rays and neutrons but only briefly consider the possibility of some minimal contribution to the total body dose by residual radiation exposure. In recognition of the need for an up-to-date review of the topic of residual radiation exposure in Hiroshima and Nagasaki, recently reported studies were reviewed at a technical session at the 57th Annual Meeting of the Health Physics Society in Sacramento, California, 22-26 July 2012. A one-day workshop was also held to provide time for detailed discussion of these newer studies and to evaluate their potential use in clarifying the residual radiation exposures to the atomic-bomb survivors at Hiroshima and Nagasaki. Suggestions for possible future studies are also included in this workshop report.

  17. Lessons from the atomic bomb about secondary MDS.

    Science.gov (United States)

    Hata, Tomoko; Imanishi, Daisuke; Miyazaki, Yasushi

    2014-12-01

    Myelodysplastic syndromes (MDSs) is a hematological neoplasm defined by ineffective hematopoiesis, dysplasia of hematopoietic cells, and risk of progression to acute leukemia. MDS occurs as de novo or secondary, and chemoradiotherapy for cancers is thought to increase the risk of MDS among patients. Recently, an epidemiological study for MDS among A-bomb survivors was performed, and it clearly demonstrated that the exposure to external radiation significantly increased the risk of MDS. Precise epidemiological data among survivors have revealed important clinical factors related to the risk of leukemias. In this review, by comparing data for secondary MDS and leukemia/MDS among survivors, several factors which would affect the risk of MDS, especially secondary MDS, are discussed.

  18. Investigation of stomach diseases in atomic bomb survivors, 6

    International Nuclear Information System (INIS)

    Kato, Masafumi; Matsumoto, Yasuko; Mito, Kazuyo; Kumazawa, Toshihiko; Ito, Chikako.

    1986-01-01

    This is a report of the results of gastric mass survey performed during a 3-year period from 1982 through 1984. Included in this survey were 16,781 A-bomb survivors. The subjects were divided into three groups: a group exposed at ≤ 2,000 m from ground zero (Group 1), a group exposed at > 2,000 m from ground zero (Group 2), and a group consisting of those who entered the city after the bombing or others (Group 3). Regarding the rate for necessity of detailed examinations, there was no difference among the groups. The incidence of abnormal findings was 6.1 % in Group 1, 5.4 % in Group 2, and 4.9 % in Group 3, showing significant difference between Groups 1 and 3. Similarly, the incidence of respective disease was significantly higher in Group 1 than Group 3: gastritis was the most common (2.7 % vs 2.0 %), followed by gastric polyp (0.9 % vs 0.5 %) and gastric cancer (0.6 % vs 0.2 %). The age-adjusted incidence of gastric cancer and polyp was high, irrespective of sex, in Group 1. This was significant for gastric cancer in women and for gastric polyp in men. The incidence of gastric cancer in any age class was higher in Group 1 than Group 3. The incidence of gastric polyp tended to increase with aging in Group 1, being higher particularly for survivors over the age of 50 than those in Groups 2 and 3. (Namekawa, K.)

  19. Organ doses to atomic bomb survivors from radiological examinations at the Radiation Effects Research Foundation

    International Nuclear Information System (INIS)

    Kato, Kazuo; Antoku, Shigetoshi; Sawada, Shozo; Russell, W.J.

    1990-04-01

    When estimating the risks of oncogenesis and cancer mortality as a result of atomic bomb radiation exposure, medical X-ray doses received by the A-bomb survivors must also be estimated and considered. Using a phantom human, we estimated the X-ray doses received by A-bomb survivors during routine biennial medical examinations conducted at RERF as part of the long-term Adult Health Study (AHS), since these examinations may represent about 45 % of the survivors' total medical irradiations. Doses to the salivary glands, thyroid gland, lung, breast, stomach and colon were measured using thermoluminescent dosimeters. The results reported here will aid in estimating organ doses received by individual AHS participants. (author)

  20. Leukaemia following childhood radiation exposure in the Japanese atomic bomb survivors and in medically exposed groups

    International Nuclear Information System (INIS)

    Little, M. P.

    2008-01-01

    Incidence and mortality risks of radiation-associated leukaemia are surveyed in the Japanese atomic bomb (A-bomb) survivors exposed in early childhood and in utero. Leukaemia incidence and mortality risks are also surveyed in 16 other studies of persons who received appreciable doses of ionizing radiation in the course of treatment in childhood and for whom there is adequate dosimetry and cancer incidence or mortality follow-up. Relative risks tend to be lower in the medical series than in the Japanese A-bomb survivors. The relative risks in the medical studies tend to diminish with increasing average therapy dose. After taking account of cell sterilisation and dose fractionation, the apparent differences between the relative risks for leukaemia in the Japanese A-bomb survivors and in the medical series largely disappear. This suggests that cell sterilisation largely accounts for the discrepancy between the relative risks in the Japanese data and the medical studies. Excess absolute risk has also been assessed in four studies, and there is found to be more variability in this measure than in excess relative risk. In particular, there is a substantial difference between the absolute risk in the Japanese atomic bomb survivor data and those in three other (European) populations. In summary, the relative risks of leukaemia in studies of persons exposed to appreciable doses of ionizing radiation in the course of treatment for a variety of malignant and non-malignant conditions in childhood are generally less than those in the Japanese A-bomb survivor data. The effects of cell sterilisation can largely explain the discrepancy between the Japanese and the medical series. (authors)

  1. Subclinical hyperthyroidism (Sh) in atomic-bomb survivors in Japan

    International Nuclear Information System (INIS)

    Ashizawa, K.; Imaizumi, M.; Usa, T.; Tominaga, T.; Hida, A.; Ejima, E.; Neriishi, K.; Soda, M.; Fujiwara, S.; Maeda, R.; Akahoshi, M.; Nagataki, S.; Eguchi, K.

    2005-01-01

    Full text: Purpose/Background Subclinical hyperthyroidism (Sh) is defined as a biochemical abnormality characterized by a subnormal level of TSH with otherwise normal thyroid tests (F T 3 , F T 4 ) and no clinical symptoms. There are only a small number of cross-sectional studies on the prevalence of Sh. With the improvement of the sensitivity of TSH assay, it has become possible to survey the clinical significance of Sh. With regard to both Sh and subclinical hypothyroidism, discussions are being focused on such as the necessity of treatment. In order to elucidate the clinical significance of Sh, examination data of A-bomb survivors in Hiroshima and Nagasaki were analyzed. Subjects and Method Between 2000 and 2003, of 4,090 A-bomb survivors (1,352 males and 2,738 females with average age of 70.7), 75 individuals (1.83%) with Sh were found who had normal Free T 4 (0.71∼1.51 ng/dL) and TSH<0.45 m U/L. Analysis was limited to those who had not taken antithyroid drugs or thyroxin, and the Sh group (n=35; 9 males and 26 females) was compared with a control group with TSH:0.45∼4.5 m U/L (Group C; N=3,243; 1,109 males and 2,134 females). Result: Nine individuals had TSH<0.1 m U/L. In the Sh group, six individuals were TPO antibody-positive (17%) and 14 were TG antibody-positive (40%); hence, TG antibody-positive was significantly greater in number (p=0.0096). Hematological biochemical tests showed no significant difference between the two groups. Electrocardiograms indicated that more individuals had atrial fibrillation [p=0.028; Odds ratio (OR)=3.98; 95% Confidential interval (CI)=1.2-13.7] or ventricular premature contraction [p=0.016; OR=3.29; 95% CI=1.3-8.6] in the Sh group. In terms of the presence or absence of diabetes, dyslipidemia, hypertension, and hyperuricemia, there was no difference between the two groups. One individual from the Sh group was confirmed to have Graves' disease two years later. Conclusion: Since more individuals in the Sh group were

  2. Mortality statistics of major causes of death among atomic bomb survivors in Hiroshima Prefecture from 1968 to 1982

    Energy Technology Data Exchange (ETDEWEB)

    Hayakawa, Norihiko; Ohtaki, Megu; Matsuura, Masaaki; Munaka, Masaki; Kurihara, Minoru (Hiroshima Univ. (Japan). Research Inst. for Nuclear Medicine and Biology); Ueoka, Hiroshi

    1989-06-01

    A comparative study was made on mortality during a 15-year period from 1968 to 1982 between atomic bomb survivors resident in Hiroshima Prefecture and non-exposed controls. The mortality rate for all causes of death was lower in atomic bomb survivors than in the non-exposed, but the rate was higher among those directly exposed within about 1 km than in the non-exposed. The mortality rate for malignant neoplasms was higher in atomic bomb survivors than in the non-exposed, but that for cerebrovascular disease and heart disease was lower. In examining the rate for malignant neoplasms by site, the sites showing a high mortality rate among atomic bomb survivors were almost identical to the results of the Life Span Study. For these sites, the shorter the exposure distance the higher was the mortality rate. The rate for malignant neoplasms of the uterus and stomach, and leukemia was unnaturally high among early entrants whose period after issuance of atomic bomb survivor's health handbook was short. In observing the atomic bomb survivors by the level of family destruction due to the bombing as a socio-economic factor, a tendency was observed for the mortality rate for malignant neoplasms, diseases of blood and blood-forming organs, and peptic ulcer, to be higher among survivors with severe family destruction. (author).

  3. Cancer and non-cancer effects in Japanese atomic bomb survivors.

    Science.gov (United States)

    Little, M P

    2009-06-01

    The survivors of the atomic bombings in Hiroshima and Nagasaki are a general population of all ages and sexes and, because of the wide and well characterised range of doses received, have been used by many scientific committees (International Commission on Radiological Protection (ICRP), United Nations Scientific Committee on the Effects of Atomic Radiation (UNSCEAR), Biological Effects of Ionizing Radiations (BEIR)) as the basis of population cancer risk estimates following radiation exposure. Leukaemia was the first cancer to be associated with atomic bomb radiation exposure, with preliminary indications of an excess among the survivors within the first five years after the bombings. An excess of solid cancers became apparent approximately ten years after radiation exposure. With increasing follow-up, excess risks of most cancer types have been observed, the major exceptions being chronic lymphocytic leukaemia, and pancreatic, prostate and uterine cancer. For most solid cancer sites a linear dose response is observed, although in the latest follow-up of the mortality data there is evidence (p = 0.10) for an upward curvature in the dose response for all solid cancers. The only cancer sites which exhibit (upward) curvature in the dose response are leukaemia, and non-melanoma skin and bone cancer. For leukaemia the dose response is very markedly upward curving, indeed largely describable as a pure quadratic dose response, particularly in the low dose (0-2 Sv) range. Even 55 years after the bombings over 40% of the Life Span Study cohort remain alive, so continued follow-up of this group is vital for completing our understanding of long-term radiation effects in people. In general, the relative risks per unit dose among the Japanese atomic bomb survivors are greater than those among comparable subsets in studies of medically exposed individuals. Cell sterilisation largely accounts for the discrepancy in relative risks between these two populations, although other

  4. Investigation of stomach diseases in atomic bomb survivors, 6. Gastric mass survey in atomic bomb survivors (1982 - 1984)

    Energy Technology Data Exchange (ETDEWEB)

    Kato, Masafumi; Matsumoto, Yasuko; Mito, Kazuyo; Kumazawa, Toshihiko; Ito, Chikako

    1986-11-01

    This is a report of the results of gastric mass survey performed during a 3-year period from 1982 through 1984. Included in this survey were 16,781 A-bomb survivors. The subjects were divided into three groups: a group exposed at less than or equal to 2,000 m from ground zero (Group 1), a group exposed at > 2,000 m from ground zero (Group 2), and a group consisting of those who entered the city after the bombing or others (Group 3). Regarding the rate for necessity of detailed examinations, there was no difference among the groups. The incidence of abnormal findings was 6.1% in Group 1, 5.4% in Group 2, and 4.9% in Group 3, showing significant difference between Groups 1 and 3. Similarly, the incidence of respective disease was significantly higher in Group 1 than Group 3: gastritis was the most common (2.7% vs 2.0%), followed by gastric polyp (0.9% vs 0.5%) and gastric cancer (0.6% vs 0.2%). The age-adjusted incidence of gastric cancer and polyp was high, irrespective of sex, in Group 1. This was significant for gastric cancer in women and for gastric polyp in men. The incidence of gastric cancer in any age class was higher in Group 1 than Group 3. The incidence of gastric polyp tended to increase with aging in Group 1, being higher particularly for survivors over the age of 50 than those in Groups 2 and 3. (Namekawa, K.).

  5. Fast neutron inspection of sea containers for the presence of 'dirty bomb'

    International Nuclear Information System (INIS)

    Valkovic, V.; Sudac, D.; Blagus, S.; Nad, K.; Obhodas, J.; Vekic, B.; Nebbia, G.; Pesente, S.

    2007-01-01

    The possibility of the detection of 'dirty bomb' presence inside sea containers is evaluated. The method proposed for explosive and fissile material detection makes use of two sensors (X-rays and neutrons). A commercial imaging device based on the X-ray radiography performs a fast scan of the container, identifies a 'suspect' region and provides its coordinates to the neutron based device for the final 'confirmatory' inspection. In this two sensor system a 14 MeV neutron beam defined by the detection of associated alpha particles is used for interrogation of only volume elements marked by X-ray sensor. The object's nature is determined from passive and neutron induced, gamma energy spectra measurements. Experimental results (time-of-flight and gamma energy spectra) obtained for the irradiation 30 kg of TNT, depleted uranium and other materials hidden inside the container are presented

  6. Cell biological study in multiple myeloma among atomic bomb survivors

    Energy Technology Data Exchange (ETDEWEB)

    Harada, Hironori; Kawano, Michio; Huang, Naihui; Tanabe, Osamu; Tanaka, Hideo; Sakai, Akira; Kuramoto, Atsushi (Hiroshima Univ. (Japan). Research Inst. for Nuclear Medicine and Biology)

    1992-12-01

    The study was undertaken to determine differences in the expression of cell surface antigens in normal plasma cells and mature myeloma cells. The subjects were 20 patients with multiple myeloma, including 5 A-bomb survivors. Seven normal persons, four with chronic tonsillitis, one with idiopathic thrombocytopenic purpura, and two with chronic lymphadenitis served as controls. In the group of myeloma cells, 12 showed mature myeloma cells of VLA-4[sup +]/VLA-5[sup +]/MPC-1[sup +], and the other 8 showed precursor myeloma cells of VLA-4[sup +]/VLA-5[sup -]/MPC-1[sup -]. In terms of CD56 and CD19, CD56[sup +]/CD19[sup -] were seen in 13 patients, CD56[sup -]/CD19[sup -] in 5, and CD56[sup +]/CD19[sup +] in 2; none of the patients showed phenotype of CD56[sup -]/CD19[sup +]. In the control group, all showed VLA-4[sup +]/VLA-5[sup +]/MPC-1[sup +]/CD44[sup +]/CD56[sup -]/CD19[sup +]; phenotype of normal plasma cells was CD38[sup ++]/CD56[sup -]/CD19[sup +] alone, which was not seen in the group of mature myeloma cells. Thus, this type is considered characteristic to normal plasma cells. These findings revealed that the difference in the expression of CD56 and CD19 aids in the identification of myeloma cells from normal plasma cells. (N.K.).

  7. Colorectal cancer incidence among atomic bomb survivors, 1950-80

    International Nuclear Information System (INIS)

    Nakatsuka, Hirofumi; Shimizu, Yukiko; Yamamoto, Tsutomu

    1992-01-01

    Colorectal cancer incidence in the Life Span Study (LSS) sample during 1950-80 was investigated. A total of 730 incidence cases of colorectal cancer were confirmed from a variety of sources. Sixty-two percent of the cancers were microscopically verified and 12% were ascertained through death certificate only. The risk of colon cancer increased significantly with intestinal dose, but no definite increase of risk was observed for rectal cancer. Relative risk at 1 Sv and excess risk per 10 4 PY-Sv for colon cancer are 1.80 (90% confidence interval 1.37-2.36) and 0.36 (90% confidence interval 0.06-0.77) respectively. City and sex did not significantly modify the dose-response of colon cancer, but the risk decreased with age at the time of bombings (ATB). The relative risk of colon cancer does not vary substantially over time following exposure. A non-linear dose response did not significantly improve the fit. Further, the anatomic location of the tumors indicate that the cecum and ascending, transverse and descending, and sigmoid colon seem equally sensitive to radiation. No difference in the distribution of tumor histological types could be observed by radiation dose. (author)

  8. Colorectal cancer incidence among atomic bomb survivors, 1950-80

    International Nuclear Information System (INIS)

    Hirofumi Nakatsuka; Yukiko Shimizu; Tsutomu Yamamoto; Ichiro Sekine; Haruo Ezaki; Eiichi Tahara; Makoto Takahashi; Takatoshi Shimoyama; Nobuo Mochinaga; Masao Tomita; Ryoichi Tsuchiya; Land, Charles E.

    1992-10-01

    Colerectal cancer incidence in the LSS sample during 1950-80 was investigated. A total of 730 incidence cases of colorectal cancer were confirmed from a variety of sources. Sixty-two percent of the cancers were microscopically verified and 12% were ascertained through death certificate only. The risk of colon cancer increased significantly with intestinal dose, but no definite increase of risk was observed for rectal cancer. Relative risk at 1 Sv and excess risk per 10 4 PY-Sv for colon cancer are 1.80 (90% confidence internal 1.37-2.36) and 0.36 (90% confidence interval 0.06-0.77) respectively. City and sex did not significantly modify the dos-response of colon cancer, but the risk decreased with age at the time of bombings (ATB). The relative risk of colon cancer does not vary substantially over time following exposure. A non-linear dose response did not significantly improve the fit. Further, the anatomic location of the tumors indicate that the cecum and ascending, transverse and descending, and sigmoid colon seem equally sensitive to radiation. No difference in the distribution of tumor histological types could be observed by radiation dose. (author)

  9. Atomic structure holography using thermal neutrons

    International Nuclear Information System (INIS)

    Sur, B.; Rogge, R.B.; Hammond, R.P.; Anghel, V.N.P.; Katsaras, J.

    2001-01-01

    The idea of atomic-resolution holography has its roots in the X-ray work of Bragg and in Gabor's electron interference microscope. Gabor's lensless microscope was not realized in his time, but over the past twelve years there has been a steady increase in the number of reports on atomic-resolution holography. All of this work involves the use of electrons or hard X-rays to produce the hologram. Neutrons are often unique among scattering probes in their interaction with materials: for example, the relative visibility of hydrogen and its isotopes is a great advantage in the study of polymers and biologically relevant materials. Recent work proposed that atomic-resolution holography could be achieved with thermal neutrons. Here we use monochromatic thermal neutrons, adopting the inside-source concept of Szoke, to image planes of oxygen atoms located above and below a single hydrogen atom in the oxide mineral Simpsonite. (author)

  10. Studies on preparation of the database system for clinical records of atomic bomb survivors

    International Nuclear Information System (INIS)

    Nakamura, Tsuyoshi

    1981-01-01

    Construction of the database system aimed at multipurpose application of data on clinical medicine was studied through the preparation of database system for clinical records of atomic bomb survivors. The present database includes the data about 110,000 atomic bomb survivors in Nagasaki City. This study detailed: (1) Analysis of errors occurring in a period from generation of data in the clinical field to input into the database, and discovery of a highly precise, effective method of input. (2) Development of a multipurpose program for uniform processing of data on physical examinations from many organizations. (3) Development of a record linkage method for voluminous files which are essential in the construction of a large-scale medical information system. (4) A database model suitable for clinical research and a method for designing a segment suitable for physical examination data. (Chiba, N.)

  11. A simple reductionist model for cancer risk in atom bomb survivors

    International Nuclear Information System (INIS)

    Mendelsohn, M.L.

    1995-01-01

    1) In data from the atom bomb survivors of Hiroshima and Nagasaki, the roughly linear-quadratic radiation dose responses for chromosome aberration and leukemia correspond closely to each other, as do the linear dose responses for gene mutation and solid cancer incidence. 2) In view of the increasing evidence for multiple oncogene and suppressor gene changes in human cancer, as well as the evidence that human cancer rate is often proportional to age to the power of 6 or so, it is postulated that the radiation has contributed one and only one oncogenic mutational event to the radiation induced cancers. 3) The radiation induced cancers should therefore display a cancer rate versus age relationship that has a power of n-1, where n is the power for the corresponding background cancers. 4) It is shown that this is precisely what is happening in the collective solid cancer incidence of the atom bomb survivors. (author)

  12. Mathematical phantoms for use in reassessment of radiation doses to Japanese atomic-bomb survivors

    Energy Technology Data Exchange (ETDEWEB)

    Cristy, M.

    1985-07-01

    In 1972 committees of the United Nations and the US National Academy of Sciencs emphasized the need for organ dose estimates on the Japanese atomic-bomb survivors. These estimates were then supplied by workers in Japan and the US, and they were used with the so-called T65D estimates of a survivor's radiation exposure to assess risk from radiation. Recently the T65D estimates have been questioned, and programs for reassessment of atomic-bomb radiation dosimetry have been started in Japan and the US. As a part of this new effort a mathematical analogue of the human body (or ''mathematical phantom''), to be used in estimating organ doses in adult survivors, is presented here. Recommendations on organ dosimetry for juvenile survivors are also presented and discussed. 57 refs., 10 figs., 6 tabs.

  13. Prevalence of monoclonal gammopathy of undetermined significance in Asia: a viewpoint from nagasaki atomic bomb survivors.

    Science.gov (United States)

    Iwanaga, Masako; Tomonaga, Masao

    2014-02-01

    Exposure to ionizing radiation is a known environmental risk factor for a variety of cancers including hematological malignancies, such as leukemia, myelodysplastic syndromes, and multiple myeloma. Therefore, for Hiroshima and Nagasaki atomic bomb survivors (surviving victims who were exposed to ionizing radiation emitted from the nuclear weapons), several cancer-screening tests have been provided annually, with government support, to detect the early stage of malignancies. An M-protein screening test has been used to detect multiple myeloma at an early stage among atomic bomb survivors. In the screening process, a number of patients with monoclonal gammopathy of undetermined significance (MGUS), in addition to multiple myeloma, have been identified. In 2009 and 2011, we reported the age- and sex-specific prevalence of MGUS between 1988 and 2004 and the possible role of radiation exposure in the development of MGUS using the screening data of more than 1000 patients with MGUS among approximately 52,000 Nagasaki atomic bomb survivors. The findings included: (1) a significant lower overall prevalence (2.1%) than that observed in Caucasian or African-origin populations; (2) a significantly higher prevalence in men than in women; (3) an age-related increase in the prevalence; (4) a significantly higher prevalence in people exposed to higher radiation doses only among those exposed at age 20 years or younger; and (5) a lower frequency of immunoglobulin M MGUS in Japanese patients than in patients in Western countries. The large study of MGUS among Nagasaki atomic bomb survivors has provided important findings for the etiology of MGUS, including a possible role of radiation exposure on the cause of MGUS and an ethnicity-related difference in the characteristics of MGUS. Copyright © 2014 Elsevier Inc. All rights reserved.

  14. Phagocytic and bactericidal activities of leukocytes in whole blood from atomic bomb survivors

    International Nuclear Information System (INIS)

    Sasagawa, S.; Yoshimoto, Y.; Toyota, E.; Neriishi, S.; Yamakido, M.; Matsuo, M.; Hosoda, Y.; Finch, S.C.

    1990-01-01

    This study evaluated the phagocytic and bactericidal activities of peripheral blood leukocytes from Hiroshima and Nagasaki atomic bomb survivors for Staphylococcus aureus. The data were analyzed by multiple linear regression for age, sex, radiation exposure, city of exposure, and neutrophil counts. No significant radiation effect was observed for either blood phagocytic or bactericidal activities. The only significant variable for these functions was the neutrophil count

  15. The cohort of the atomic bomb survivors major basis of radiation safety regulations

    CERN Document Server

    Rühm, W; Nekolla, E A

    2006-01-01

    Since 1950 about 87 000 A-bomb survivors from Hiroshima and Nagasaki have been monitored within the framework of the Life Span Study, to quantify radiation-induced late effects. In terms of incidence and mortality, a statistically significant excess was found for leukemia and solid tumors. In another major international effort, neutron and gamma radiation doses were estimated, for those survivors (Dosimetry System DS02). Both studies combined allow the deduction of risk coefficients that serve as a basis for international safety regulations. As an example, current results on all solid tumors combined suggest an excess relative risk of 0.47 per Sievert for an attained age of 70 years, for those who were exposed at an age of 30 years. After exposure to an effective dose of one Sievert the solid tumor mortality would thus be about 50% larger than that expected for a similar cohort not exposed to any ionizing radiation from the bombs.

  16. Mental retardation occurring in embryo exposed in utero to the atomic bomb (Hiroshima)

    International Nuclear Information System (INIS)

    Ishikawa, Hiroya; Shimasaki, Akira; Fujiwara, Koichi; Harada, Masazumi; Minami, Ryuichi.

    1978-01-01

    This paper deals with a long term follow-up study on psychological symptoms in four patients with microscopically microcephaly induced by prenatal exposed to atomic bomb. They were exposed to atomic bomb at 8- and 12-week-embryos. The distance from the center of the explosion was 780 - 1180 m. All their mothers had acute radiation hazards. Their growths in the uterus were markedly damaged. Postnatal body weight ranged between 1,300 and 2,000 g. They were commonly characterized by microcephaly, physiological and mental retardation, stigmata of degeneracy, and skin symptoms, who were diagnosed as ''microcephaly induced by early prenatal exposure to atomic bomb'' by the research group for microcephaly in the Ministry of Health and Welfare. These common symptoms such as microcephaly, stigmata of degeneracy, and disturbed growth, but neurological symptoms such as motor aphasia were slighter in these patients than in those having congenital Minamata disease prenatal. These results suggested that the prognosis of these patients in whom 30 years have passed is unexpectedly serious. (Namekawa, K.)

  17. From the Dawn of Nuclear Physics to the First Atomic Bombs

    Science.gov (United States)

    Woolbright, Stephen; Schumacher, Jacob; Michonova-Alexova, Ekaterina

    2014-03-01

    This work gives a fresh look at the major discoveries leading to nuclear fission within the historical perspective. The focus is on the main contributors to the discoveries in nuclear physics, leading to the idea of fission and its application to the creation of the atomic bombs used at the end of the World War II. The present work is a more complete review on the history of the nuclear physics discoveries and their application to the atomic bomb. In addition to the traditional approach to the topic, focusing mainly on the fundamental physics discoveries in Europe and on the Manhattan Project in the United States, the nuclear research in Japan is also emphasized. Along with that, a review of the existing credible scholar publications, providing evidence for possible atomic bomb research in Japan, is provided. Proper credit is given to the women physicists, whose contributions had not always been recognized. Considering the historical and political situation at the time of the scientific discoveries, thought-provoking questions about decision-making, morality, and responsibility are also addressed. The work refers to the contributions of over 20 Nobel Prize winners. EM-A is grateful to Prof. Walter Grunden and to Prof. Emeritus Shadahiko Kano, Prof. Emeritus Monitori Hoshi for sharing their own notes, documents, and references, and to CCCU for sponsoring her participation in the 2013 Nuclear Weapons Seminar in Japan.

  18. Mortality statistics of major causes of death among atomic bomb survivors in Hiroshima from 1968 to 1982

    Energy Technology Data Exchange (ETDEWEB)

    Hayakawa, Norihiko; Kurihara, Minoru; Munaka, Masaki (Hiroshima Univ. (Japan). Research Inst. for Nuclear Medicine and Biology) (and others)

    1991-01-01

    A comparative study was made on mortality during a 15-year period from 1968 to 1982 between atomic romb survivors resident in Hiroshima Prefecture and non-exposed controls. The mortality rate for all causes of death was lower in atomic bomb survivors than in the non-exposed, but the rate was higher among those directly exposed within about 1 km than in the non-exposed. The mortality rate for malignant neoplasms was higher in atomic bomb survivors than in the non-exposed, but that for cerebrovascular disease and heart disease was lower. In examining the rate for malignant neoplasms by site, the site showing a high mortality rate among atomic bomb survivors were almost identical to the results of the Life Span Study. For these sites, the shorter the exposure distance the higher was the mortality rate. The rate for malignant neoplasms of the uterus and stomach, and leukemia was unnaturally high among early entrants whose period after issuance of atomic bomb survivor's health handbook was short. In observing the atomic bomb survivors by the level of family destruction due to the bombing as a socio-economic factor, a tendency ws observed for the mortality rate for malignant neoplasms, diseases of blood-forming organs, and peptic ulcer, to be higher among survivors with severe family destruction. (author).

  19. Celluloid mushroom clouds: Hollywood and the atomic bomb

    Energy Technology Data Exchange (ETDEWEB)

    Evans-Karastamatis, J.A.

    1993-01-01

    This dissertation investigates the development of the imagery associated with atomic technology found in Hollywood film produced and distributed between 1948 and 1964. Based upon a content and thematic analysis of a sample of 90 Hollywood produced films, the research examines the construction of nuclear images, their transformation throughout the fifteen year period, and the specific socio-political context and conditions of production which helped determine their selection. From the early experimentation with the issue, in searching for a profitable way to present atomic subjects, to the development of a science fiction genre which capitalized upon the public's anxiety over uncontrollable transmutational properties of nuclear energy, Hollywood filmmakers chose to perpetuate certain images and ignore others. These films provided the audience with a specific set of representations for constructing a view of atomic technology and all that it entailed. The industry's production practices and economic structure, prevailing ideologies, political pressure, and the social and cultural context helped determine what representations reached the screen. The findings illustrate how texts of popular culture are constructed, as a result of often contradictory determinants which include economic practices, signifying practices, and more general social conflict. Film content consists of texts composed on the basis of stylized conventions and codes, drawing on familiar or latent cultural myths and images. Film content can capitalize upon popular anxieties through use of metaphor and selection of genres. Hollywood selectively incorporated residual themes within the culture to exploit the fears and anxieties of audiences, and to allow a venue for questioning the wisdom of official government agenda. These potentially oppositional sentiments were defused, and governmental criticism and pressure avoided by holding the images within the margins of cold war ideology.

  20. The quantum exodus jewish fugitives, the atomic bomb, and the holocaust

    CERN Document Server

    Fraser, Gordon Murray

    2012-01-01

    It was no accident that the Holocaust and the Atomic Bomb happened at the same time. When the Nazis came into power in 1933, their initial objective was not to get rid of Jews. Rather, their aim was to refine German culture: Jewish professors and teachers at fine universities were sacked. Atomic science had attracted a lot of Jewish talent, and as Albert Einstein and other quantum exiles scattered, they realized that they held the key to a weapon of unimaginable power. Convincedthat their gentile counterparts in Germany had come to the same conclusion, and having witnessed what the Nazis were

  1. Fallout: Hedley Marston and atomic bomb tests in Australia

    International Nuclear Information System (INIS)

    Cross, R.T.

    2001-01-01

    This book tells the story of Australian scientists involved in the 1956 British atomic tests at Maralinga. The story involves several of the country's most respected and trusted scientists of the 1950s and spills over to the scientific organisations that mattered. As the drama unfolds we see how the controversy touched the lives of many senior Australian scientists, and in a few cases those of British scientists, too. What is described in this book, however, is more than an esoteric scientific dispute kept within laboratory walls; it is a story about the nature of science in relation to society that continues into the present day. This controversy was, and is, about the health effects of low-level ionising radiation. There is still, after all these years, intense debate about the health effects of low-level ionising radiation to which from time to time most Australians are exposed through the dental and medical industry

  2. Statistical studies on heart disease of the pathological autopsy cases in the Atomic Bomb Hospital

    International Nuclear Information System (INIS)

    Matushita, Hiroshi; Hamada, Tadao; Ishida, Sadamu.

    1976-01-01

    Of 1230 autopsied cases in the Atomic Bomb Hospital and in the Red-Cross Hospital from 1956 to March, 1975, a statistical study was made on 118 cases in which primary or secondary heart disease had been found. The results are as follows. The incidence of myocardial infarction was 2.4 times higher in the group exposed to the atomic bomb within 2 km distance from the bombed area than that it was in the unexposed group. The incidence of acquired valvular disease was 4.1 times higher in the exposed group than in the unexposed group. From the standpoint of the incidence of myocardiosis, there was no difference between the groups. The incidence of pericarditis was 1.5 times higher in the exposed group than in the unexposed group. The incidence of cor pulmonale was 1.8 times higher in the exposed group than in the unexposed group. The incidence of other heart disease including congenital disease was, however, 1.6 times higher in the unexposed group than in the exposed group. The incidence of general heart disease was 1.7 times higher in the exposed group than in the unexposed group. The incidence of hypertrophy of the heart (more than 400 g) was 1.2 times higher in the exposed group than in the unexposed group. (Namekawa, K.)

  3. Survival experience of atomic bomb survivors, Hiroshima and Nagasaki, 1951 - 76

    International Nuclear Information System (INIS)

    Moriyama, I.M.; Guralnick, L.

    1979-10-01

    This report is a review of the experience of persons in the Life Span Study sample exposed to the atomic bombs in 1945 as reflected by survival rates for the period 1951-76. The greatest effect is on the population less than 10 years of age at the time of the bombs (ATB) exposed to 100 rad or more. The survival rates for both sexes in the two cities declined significantly below those for the controls. This change occurred after a latent period. There has been an unusual acceleration in the decline in survival rates for the group aged 25 - 44 years ATB but this does not appear to be raidation related inasmuch as both the exposed and nonexposed populations in the two cities are similarly affected. (author)

  4. Late effects of atomic bomb radiation on human immune responses, (3)

    International Nuclear Information System (INIS)

    Kusunoki, Yoichiro; Akiyama, Mitoshi; Kyoizumi, Seishi; Hakoda, Masayuki; Kohno, Nobuoki; Zhou, Ou-Liang; Akiba, Suminori

    1988-01-01

    In an effort to examine whether or not natural killer (NK) cell activation with IL-2 was influenced by atomic bombing, NK cell activity, the ratio of lymphocytes seropositive for NK cell-related antigens, and NK cell activation with IL-2 were examined in 328 A-bomb survivors in Hiroshima. NK activity and the ratio of lymphocytes seropositive for Leu 7, Leu 11 and OKM 1 antigens were higher in men than women. These findings became more marked with advancing age in both men and women. An activation of NK cells was significantly stimulated with IL-2. This was significantly correlated with an increase in the seropositive rate for Leu 11 antigen. NK cell activation, as expressed as stimulation index, was significantly higher in women than men. In neither men nor women was there correlation between stimulation index and both aging and exposure doses. (Namekawa, K.)

  5. Recent results concerning radiation-induced cancer in the Japanese atomic bomb survivors

    International Nuclear Information System (INIS)

    Radford, E.P.

    1988-01-01

    The most recent data of the prospective study among Hiroshima and Nagasaki atomic bomb survivors support the following conclusions: (a) the dose-response relationship is consistent with a straight line through the origin, including the lowest dose group (approx. 3 rad); (b) sensitivity to cancer induction varies considerably by irradiated tissues. (c) most cancers show a radiation effect still increasing 40 years after exposure; (d) a small leukemia excess among those irradiated is still present in Hiroshima; (e) the thyroid cancer excess is declining at present; (g) smoking adds to lung cancer incidence; (g) certain benign tumors show a radiation-related effect; (h) children under 10 years old at time of bombing are presently showing the highest relative cancer risk compared to other survivors at equal attained age. If this effect persists, age-specific cancer risk coefficients are necessary [fr

  6. Lymphocyte subsets and response to PHA among atomic bomb survivors

    International Nuclear Information System (INIS)

    Nakao, Susumu; Noguchi, Kyouichi; Eida, Kazuyuki; Tashiro, Kazunori; Hayashida, Ken

    1986-01-01

    In an effort to elucidate the effect of radiation exposure on immune competence in man, the number of lymphocytes, lymphocyte subsets, and the percentage of phytohemagglutinin (PHA)-induced transformation of lymphocytes were determined in 66 cancer patients, 25 of whom were exposed to atomic radiation at ≤ 2,000 m from ground zero and 41 others were not exposed. The number of lymphocytes was decreased with increasing age at exposure. The percentage of OKT3-positive cells tended to be lower in exposed patients who were in their twenties at the time of exposure than the non-exposed patients. Among patients in their teens and twenties at the time of exposure, there was a tendency toward decreased percentage of OKT4-positive cells (T4) and increased percentage of OKT8-positive cells (T8). The T4/T8 ratio was reduced. Patients who were in their first decade of life at the time of exposure tended to have decreased OKIa 1-positive cells, and increased Leulla-positive cells. Patients exposed in their twenties and thirties had slightly decreased percentage of PHA-induced transformation of lymphocytes. (Namekawa, K.)

  7. Cytogenetic and molecular genetic analysis of leukemias found in atomic bomb survivors

    International Nuclear Information System (INIS)

    Kamada, Nanao; Tanaka, Kimio; Eguchi, Mariko

    1994-01-01

    Seventy five radiation-related leukemia patients in Hiroshima including 16 patients exposed to more than one Gray were cytogenetically examined. Statistical analysis of data on the frequencies of chromosomal aberrations in the survivor groups according to bone marrow doses by DS86 estimation revealed that the heavily exposed group tended to have significantly higher aberration rates compared to the non-exposed group. Furthermore, the chromosomal aberrations in the survivors were observed to be of a more complex nature and had the characteristic findings of secondary leukemia. These observations therefore suggest that patients with a history of heavy exposure to atomic bomb radiation had leukemic cells originating from a stem cell which had been damaged by irradiation at the time of the bombing as well as cells involved in complex chromosome abnormalities. A higher incidence(p=0.06) of 11q23 abnormality was found in acute leukemia patients who had a history of exposure to A-bomb and developed from 1986 to 1993. However, we could not detect rearrangement of MLL gene in these patients. Break point region on 11q23 of radiation induced leukemias may be different from the common 8.5 kb region. Molecular biologic studies on RAS genes in acute and chronic leukemias and the BCR gene in chronic myelocytic leukemia were performed in exposed and non-exposed groups. So far, no distinctive differences have been observed in the frequency and sites of point mutations in N and K-RAS genes or in the rearrangement of the BCR gene. Further, retrospective analysis using DNA from leukemia patients who developed the disease in the early period from atomic bomb radiation exposure would be useful for elucidation of the mechanisms of radiation-induced leukemia. (author)

  8. Mortality among the offspring (F1) of atomic bomb survivors, 1946-85

    International Nuclear Information System (INIS)

    Yoshimoto, Yasuhiko; Schull, W.J.; Kato, Hiroo; Neel, J.V.

    1991-03-01

    We compare deaths occurring in the years 1946-85 in a cohort of 31,159 children born to parents one or both of whom were exposed to the atomic bombing of Hiroshima or Nagasaki, and received a combined (i.e., joint) gonadal dose of 0.01 Sv or more, with deaths in a comparable control group, totaling 41,069 children. The average combined gonadal dose equivalent for the exposed parents was 0.435 Sv. Gonadal doses were calculated using the recently established DS86 system, supplemented by an ad hoc system for those children for whom a DS86 dose could not be computed for one or both parents. The mean age of living members of the cohorts was 28.8 years. When a linear relative risk model is fitted to the data, no statistically significant increase in the risk of mortality attributable to diseases other than neoplasms is noted following parental exposure, the excess relative risk being 0.030 (±0.046) per sievert based on the subset of individuals with DS86 doses, assuming the RBE of neutrons to be 20. For fatal cancer, in confirmation of an earlier report on cancer incidence below the age of 20 in this same group, again no statistically significant effect was observed as parental radiation dose increased. This model was also fitted to the data used in the relative risk estimate to provide some continuity with the past. The results give an intercept of 0.0420(±0.0015) and a linear regression coefficient of 0.00169 (±0.00157) per sievert. This leads to the calculation of a (statistically nonsignificant) excess relative risk of 0.040, in good agreement with the excess obtained by fitting the relative risk model. An analysis based on the full sample, using not only the DS86 dose group but also the ad hoc dose group, yields essentially the same result as the analysis restricted to the DS86 dose group. (J.P.N.)

  9. The delayed effects of radiation exposure among atomic bomb survivors, Hiroshima and Nagasaki, 1945-79

    International Nuclear Information System (INIS)

    Finch, S.C.; Moriyama, I.M.

    1980-07-01

    The most important radiation-induced late medical effect in the atomic bomb survivors of Hiroshima and Nagasaki has been the increased occurrence of certain neoplasms, specifically, leukemia and cancers of the thyroid, lung, and breast. Other definite radiation-related effects include an increase in posterior lenticular opacities, chromosome aberrations in peripheral blood lymphocytes, and some abnormalities of growth and development following irradiation while in utero or during childhood. Moderate to fairly strong associations between A-bomb exposure and the increased occurrence of stomach cancer, multiple myeloma, and several other types of cancer have been observed. Radiation relationships also are suggestive for alterations of certain aspects of immune mechanisms and the increased occurrence of myelofibrosis. No increase in genetic effects has been demonstrated in the children born of exposed parents, and studies to data have been negative for evidence of increased infertility, accelerated aging, or increased mortality from diseases other than cancer. In general, the radiation dose-response relationships for most positive effects have been higher in Hiroshima than in Nagasaki, and the shape of the dose-response curves for certain effects is different in the two cities. These differences may be related to differences in the quality of the radiation from the two A-bombs. For several radiation-related effects the latent period following exposure is shorter and the incidence rate is higher in personse exposed when young as compared to exposure later in life. (author)

  10. Radiation-related risks of non-cancer outcomes in the atomic bomb survivors.

    Science.gov (United States)

    Ozasa, K; Takahashi, I; Grant, E J

    2016-06-01

    Risks of non-cancer outcomes after exposure to atomic bomb (A-bomb) radiation have been evaluated among the Life Span Study (LSS) cohort and its subcohort, the Adult Health Study (AHS). Information regarding non-cancer outcomes in the LSS is obtained from death certificates. In the AHS, members undergo clinical examinations biennially to determine their health status. Many AHS studies have been limited to participants attending the clinic over a limited period, and therefore have varying degrees of inferential utility; as such, care is required for comparison with the LSS results. Disease structure of non-cancer diseases in Japan has changed over the long follow-up period since the end of World War II. The health status of the A-bomb survivors may be associated with the hardships of living in a devastated city and impoverished country following the prolonged war effort, in addition to the direct effects of radiation exposure. Radiation-related risk of cardiovascular disease may have increased due to radiation-related increased risk of hypertension and other secondary associations, and the risk of atherosclerotic disorders has also been reported recently. These results should be interpreted with caution because of changes in disease definitions over the follow-up period. The radiation-related risk of non-cancer respiratory diseases also appears to have increased over the follow-up period, but the shapes of the dose-response curves have shown little consistency. © The International Society for Prosthetics and Orthotics.

  11. Public health nutritional studies on the atomic bomb female survivors living in Hiroshima

    International Nuclear Information System (INIS)

    Munaka, Masaki; Yamamoto, Hisashi; Ohtaki, Megu; Ueoka, Hiroshi; Kishida, Noriko; Ishigai, Keiko.

    1982-01-01

    The atomic bomb survivors group exposed at a long distance (LDG) was found to take a great quantity of soybean curd, miso and fruit except citrus, while the atomic bomb survivors group exposed at a short distance (SDG) was found to take a significant amount of fish paste product. SDG tends to ingest processed food and in nutrient supply rate the percentage of calcium, iron and vitamin A is low. Judging from a state of food group without a meal rate, we got the result that SDG has a few kinds of ingestion food and takes them partially in each meal. In terms of socio-economic status, the rate of living alone, supporting oneself and living an empty life is high and the rate of living with a partner is low. On the other hand, we analysed the relations of three factors on physique-physical fitness and living status, and then got the following results. (1) ''Volume capacity'', in the cases of ''be married at present'', ''have a large family'', ''ingest a lot of protein and iron'', tends to be large, while in the cases of ''have no disease'', ''don't go without a meal'', ''ingest a lot of carbohydrates (non-fibrous)'', and ''nutritional balance is good'', it tends to be small. (2) ''Height'', in the case of ''socio-economical status was good before exposure to the atomic bomb'', tends to increase. (3) ''Synthetic physical fitness'', in the cases of ''health condition is good at present'', ''have no disease at present'', ''ingest a lot of vitamin A'' and ''nutritional balance is good'', tends to be superior; in the cases of ''food cost is high'' and ''ingest a lot of carbohydrates (non-fibrous)'', it tends to be low. The significant difference was observed in ''synthetic physical fitness'' between the two age groups of 50-59 years and beyond 70 years. (J.P.N.)

  12. Studies of colorectal cancer among atomic bomb survivors in Hiroshima, 1950-1980

    International Nuclear Information System (INIS)

    Nakatsuka, Hirofumi

    1985-01-01

    Among the 82,064 subjects, 595 cases of colorectal cancer were confirmed, 395 cases (66.4%) by microscopic examinations of histological specimens and 69 cases (11.6%) by death certificate only. Subjects with unknown exposure dose or who were not in Hiroshima city at the time of the bombing were excluded, and the analysis was based on 60,470 persons with estimated exposure dose. In this population, there were 450 colorectal cancer cases: 239 cases of colon cancer, 203 cases of rectal cancer and eight cases with unknown site. Concerning the relationship between incidence of colorectal cancer and radiation exposure, the following conclusions were obtained: 1. The incidence of colorectal cancer increased with radiation dose, and this tendency was observed in both sexes. 2. The risk of colon cancer increased with dose, and linear trend tests showed that the increase was significant both in males (p<0.05) and females (p<0.01). The effects of radiation on the incidence of colon cancer differed by age at the time of the bombing. Among survivors exposed at young ages (less than 20) the effects were especially remarkable, the relative risk of the 100+ rad group versus the 0 rad group being 6.2, which was significantly greater than unity (p<0.01). Further, by site of colon cancer, radiation dose effects on the incidence of cancer of the right side colon (cecum and ascending colon), and sigmoid colon were observed, while dose effects on the incidence of the transverse colon or descending colon were not. 3. No effects atomic bomb radiation on the incidence of rectal cancer could be demonstrated, even when examined by sex and age at the time of the bombing. 4. For both colon cancer and rectal cancer, no difference in the distribution of tumor histological types could be observed by radiation dose. (J.P.N.)

  13. A synthetic medical and sociological study on twins exposed by atomic bomb, 8

    International Nuclear Information System (INIS)

    Satow, Yukio; Watanabe, Shoji; Kyo, Taiichi

    1984-01-01

    The relationship between immunoglobulin (IgG, IgA, IgM) levels and the exposure status was examined in 13 enzygotic twin pairs who had been exposed to atomic bomb under the same or different conditions and who had no disease showing changes in immunoglobulin levels. The difference in immunoglobulin levels tended to be smaller between the twins exposed under the same conditions and to be larger between the twins exposed under the different conditions. This should be further studied because there were some exceptions in this study. (Namekawa, K.)

  14. Risk of cancer and non-cancer diseases in the atomic bomb survivors.

    Science.gov (United States)

    Ozasa, Kotaro; Shimizu, Yukiko; Sakata, Ritsu; Sugiyama, Hiromi; Grant, Eric J; Soda, Midori; Kasagi, Fumiyoshi; Suyama, Akihiko

    2011-07-01

    Late health effects of exposure to atomic bomb radiation have been evaluated in survivors. A cohort of 120 321 people has been followed since 1950 for mortality, including the cause of death using the Japanese population registry system (Life Span Study), and for cancer incidence using population-based cancer registries. Findings have included a markedly increased risk of leukaemia several years after the exposure, increased risk of various malignant tumours several decades after the exposure and, more recently, findings of increased rates of non-cancer diseases such as cardiovascular diseases.

  15. Public health nutritional studies on the atomic bomb female survivors living in Hiroshima

    Energy Technology Data Exchange (ETDEWEB)

    Munaka, Masaki (Hiroshima Univ. (Japan). Research Inst. for Nuclear Medicine and Biology)

    1983-08-01

    The dietary life and socio-economic status of atomic bomb female survivors living in Hiroshima were investigated. The atomic bomb survivors group exposed at a long distance (LDG) was found to take a great quantity of soybean curd, miso and fruit except citrus, while the atomic bomb survivors group exposed at a short distance (SDG) was found to take a significant amount of fish paste products. SDG tends to ingest processed food and in nutrient supply rate the percentage of calcium, iron and vitamin A is low. Judging from a state of food group without a meal rate, we got the result that SDG has a few kinds of ingestion food and takes them partially in each meal. In terms of socio-economic status, the rate of living alone, supporting oneself and living an empty life is high and the rate of living with a partner is low. On the other hand, we analysed the relations of three factors on physique.physical fitness and living status, and then got the following results. (1) ''Volume capacity'', in the cases of ''be married at present'', ''have a large family'', ''ingest a lot of protein and iron'', tends to be large, while in the cases of ''have no dis ease'', ''don't go without a meal'', ''ingest a lot of carbohydrates (non-fibrous)'', and ''nutr itional balance is good'', it tends to be small. (2) ''Height'', in the case of ''socio-economical status was good before exposure to the atomic bomb'', tends to increase. (3) ''Synthetic physical fitness'', in the cases of ''health condition is good at present'', ''have no disease at present'', ''ingest a lot of vitamin A'' and ''nutritional balance is good'', tends to be superior; in the cases of ''food cost is high

  16. Public health nutritional studies on the atomic bomb female survivors living in Hiroshima

    International Nuclear Information System (INIS)

    Munaka, Masaki

    1983-01-01

    The dietary life and socio-economic status of atomic bomb female survivors living in Hiroshima were investigated. The atomic bomb survivors group exposed at a long distance (LDG) was found to take a great quantity of soybean curd, miso and fruit except citrus, while the atomic bomb survivors group exposed at a short distance (SDG) was found to take a significant amount of fish paste products. SDG tends to ingest processed food and in nutrient supply rate the percentage of calcium, iron and vitamin A is low. Judging from a state of food group without a meal rate, we got the result that SDG has a few kinds of ingestion food and takes them partially in each meal. In terms of socio-economic status, the rate of living alone, supporting oneself and living an empty life is high and the rate of living with a partner is low. On the other hand, we analysed the relations of three factors on physique.physical fitness and living status, and then got the following results. (1) ''Volume capacity'', in the cases of ''be married at present'', ''have a large family'', ''ingest a lot of protein and iron'', tends to be large, while in the cases of ''have no dis ease'', ''don't go without a meal'', ''ingest a lot of carbohydrates (non-fibrous)'', and ''nutr itional balance is good'', it tends to be small. (2) ''Height'', in the case of ''socio-economical status was good before exposure to the atomic bomb'', tends to increase. (3) ''Synthetic physical fitness'', in the cases of ''health condition is good at present'', ''have no disease at present'', ''ingest a lot of vitamin A'' and ''nutritional balance is good'', tends to be superior; in the cases of ''food cost is high'' and ''ingest a lot of carbohydrates (non-fibrous)'', it tends to be low. The significant difference was observed in ''synthetic physical fitness'' between the two age groups of 50-59 years and beyond 70 years. (author)

  17. Alternatives to the BEIR relative risk model for explaining atomic-bomb survivor cancer mortality

    International Nuclear Information System (INIS)

    Cohen, B.L.

    1987-01-01

    The apparent failure of the BEIR absolute risk model to explain the data on the Japanese atomic-bomb survivors does not imply that the BEIR relative risk model (RRM) is correct. RRM is objectionable in that it fits the data only in conjunction with an assumption not in accord with current knowledge and thinking. Contrary to what is widely believed, RRM is not a consequence of, or consistent with, initiator-promoter theories; models derived from initiator-promoter theories fit the data with fewer adjustable parameters and without requiring unpalatable assumptions. The preferable models give substantially lower radiation risks

  18. Comparison of rescue and relief activities within 72 hours of the atomic bombings in Hiroshima and Nagasaki.

    Science.gov (United States)

    Matsunari, Yuko; Yoshimoto, Nao

    2013-12-01

    To clarify the factors and reasons for the differences in the outcomes of rescue and relief efforts in Hiroshima and Nagasaki, mainly focusing on the numbers of rescue/relief staffs and casualties in the period within 72 hours of the atomic bombings in August 1945. By retrieving the data and information from the records and reports concerning the disasters in the two cities, together with other publications as to the damages by the atomic bombings and subsequent rescue-relief activities, and restoration activities. It seems that there was less damage in Nagasaki, where a stronger atomic bomb was used than in Hiroshima. There were crucial geographic factors that led to the different effects in terms of the numbers of victims; however, systematic organization and mobilization of rescue and relief staffs, maintenance of functional transportation, and advanced medical knowledge and public warning with regard to disaster all may have contributed to a lower death toll and increase in survivors in Nagasaki.

  19. Selection, follow-up, and analysis in the Atomic Bomb Casualty Commission Study

    International Nuclear Information System (INIS)

    Jablon, S.

    1985-01-01

    More is known about ionizing radiation as a cause of human cancer than about any other carcinogen. Most of this knowledge is derived from the studies conducted by the Atomic Bomb Casualty Commission and Radiation Effects Research Foundation on about 100,000 Japanese survivors of the atomic bombing in 1945. The importance of these studies is based on the large size of the exposed population and the fact that individual estimates of radiation dose were possible. These factors and the combined excellence of the centralized vital statistics reporting and population registration systems in Japan have made feasible the continuing longitudinal studies of cancer mortality by site in relation to radiation dose over a span of more than 30 years. Excellent voluntary cooperation by the survivors has enabled the continuation of a biennial physical examination program which has made possible the acquisition of blood for studies of radiation-induced chromosomal aberrations and mutations at the level of specific genes. Similarly, with the cooperation of local universities, hospitals, and physicians, tumor and tissue registries necessary for the study of cancer incidence have been developed. An autopsy pathology program has enabled study of the accuracy of cause of death certification

  20. Levels of parathyroid hormone and calcitonin in serum among atomic bomb survivors

    International Nuclear Information System (INIS)

    Fujiwara, Saeko; Yokoyama, Naokata; Sasaki, Hideo; Kodama, Kazunori; Sposto, R.; Shimaoka, Katsutaro; Shiraki, Mastaka

    1994-01-01

    To examines the potential causes of increased levels of calcium in serum with increasing dose of atomic bomb radiation, which was obtained from the previous preliminary analysis, levels of parathyroid hormone (PTH) and calcitonin in serum were examined among 1459 subjects in Hiroshima and Nagasaki. A significant effect of radiation on levels of calcium, PTH and calcitonin in serum was found, even after patients with hyperparathyroidism were excluded. The level of calcium in serum increased with radiation dose; this can be explained partly by the increase in the level of PTH with radiation dose. However, the dose effect on calcium remained even after adjustment for PTH, calcitonin and confounding factors such as renal function, serum albumin level and medication. Parathyroid hormone increased initially by 6.8% per gray, but the dose response leveled off after about 1 Gy. The level of calcitonin increased with radiation dose, probably in part due to feedback mechanisms stimulated by the increase in calcium. However, after adjustment for the level of calcium, the increase in the level of calcitonin with dose was still found. Although the etiological mechanisms of the effect of radiation on serum levels of calcium, PTH and calcitonin are unclear, radiation exposure may affect secretion of PTH and calcitonin and regulation of calcium a long time after atomic bomb exposure. 21 refs., 3 figs., 6 tabs

  1. Listeria monocytogenes meningitis in an atomic bomb survivor receiving corticosteroid therapy for aplastic anemia

    International Nuclear Information System (INIS)

    Fujihara, Kazuo; Shida, Norihiko; Ohta, Michiya

    1995-01-01

    We report a case of successfully treated Listeria monocytogenes (Lm) meningitis in a atomic bomb survivor receiving steroid therapy for aplastic anemia. The patient was a 62-year-old woman and the past medical history included hypothyroidism due to radioiodide therapy for Basedow disease, breast cancer, aplastic anemia, steroid-induced diabetes mellitus, and pulmonary tuberculosis. At the time of onset, she was receiving corticosteroid, anabolic steroid, an H 2 -blocker (famotidine), and other medication. Since she developed symptoms of meningitis when she visited our hospital for regular medical check-up for aplastic anemia, she was hospitalized and given antibiotic therapy, including ABPC, without delay. With this effective antibiotic therapy and successful management of the co-existing medical conditions, she was cured except for being a little euphoric. Lm meningitis is known to occur in aged and immunocompromised patients. Since most of the atomic bomb survivors are now aged and the prevalence of malignancy, diabetes mellitus, and other diseases which cause immunodeficiency have been rising year by year, Lm meningitis is one of the emergency neurologic conditions whose diagnosis should not be delayed in this population. (author)

  2. New approaches to evaluating the genetic effects of the atomic bombs

    International Nuclear Information System (INIS)

    Neel, J.V.

    1995-01-01

    In the aftermath of the atomic bombings of Hiroshima and Nagasaki fifty years ago, one of the compelling biomedical questions that arose concerned the genetic effects of this exposure. More recently, revelations of the extent of industrial or accidental exposures in the former Soviet Union and charges that employment in the Sellafield Nuclear Reprocessing Plant in West Cumbria, England has resulted in a gene-mediated increase in children of plant employees have served to keep in the public mind the issue of the genetic risks of exposure to ionizing radiation. The study of the genetic effects of the atomic bombs has moved from the gross morphological level of congenital malformations to the examination of DNA. However, were the need for such genetic studies to arise in the foreseeable future, despite this impressive progress in DNA-oriented systems, the documentation of congenital defect, genetic disease and child survival would still be an essential component of any future study. Whatever the geneticists may think, the phenotypic well-being and survival of children are still the primary indicators on which the public, who ultimately supports these studies, will base its judgement of risk. 28 refs

  3. Genetic effects of radiation in atomic-bomb survivors and their children. Past, present and future

    International Nuclear Information System (INIS)

    Nakamura, Nori

    2006-01-01

    Genetic studies in the offspring of atomic bomb survivors have been conducted since 1948 at the Atomic Bomb Casualty Commission and its successor, the Radiation Effects Research Foundation, in Hiroshima and Nagasaki. Past studies include analysis of birth defects (untoward pregnancy outcome; namely, malformation, stillbirth, and perinatal death), chromosome aberrations, alterations of plasma and erythrocyte proteins as well as epidemiologic study on mortality (any cause) and cancer incidence (the latter study is still ongoing). There is, thus far, no indication of genetic effects in the offspring of survivors. Recently, the development of molecular biological techniques and human genome sequence databases made it possible to analyze DNA from parents and their offspring (trio-analysis). In addition, a clinical program is underway to establish the frequency of adult-onset multi-factorial diseases (diabetes mellitus, high blood pressure, and cardiovascular disease etc) in the offspring. The complementary kinds of data that will emerge from this three-pronged approach (clinical, epidemiologic, and molecular aspects) promise to shed light on health effects in the offspring of radiation-exposed people. (author)

  4. Cancer risk among atomic bomb survivors. The RERF Life Span Study. Radiation Effects Research Foundation

    International Nuclear Information System (INIS)

    Shimizu, Y.; Schull, W.J.; Kato, H.

    1990-01-01

    This article summarizes the risk of cancer among the survivors of the atomic bombing of Hiroshima and Nagasaki. We focus primarily on the risk of death from cancer among individuals in the Life Span Study sample of the Radiation Effects Research Foundation from 1950 through 1985 based on recently revised dosimetry procedures. We report the risk of cancer other than leukemia among the atomic bomb survivors. We note that the number of excess deaths of radiation-induced malignant tumors other than leukemia increases with age. Survivors who were exposed in the first or second decade of life have just entered the cancer-prone age and have so far exhibited a high relative risk in association with radiation dose. Whether the elevated risk will continue or will fall with time is not yet clear, although some evidence suggests that the risk may be declining. It is important to continue long-term follow-up of this cohort to document the changes with time since exposure and to provide direct rather than projected risks over the lifetime of an exposed individual

  5. Listeria monocytogenes meningitis in an atomic bomb survivor receiving corticosteroid therapy for aplastic anemia

    Energy Technology Data Exchange (ETDEWEB)

    Fujihara, Kazuo; Shida, Norihiko; Ohta, Michiya [Hiroshima Atomic Bomb Hospital (Japan)

    1995-12-01

    We report a case of successfully treated Listeria monocytogenes (Lm) meningitis in a atomic bomb survivor receiving steroid therapy for aplastic anemia. The patient was a 62-year-old woman and the past medical history included hypothyroidism due to radioiodide therapy for Basedow disease, breast cancer, aplastic anemia, steroid-induced diabetes mellitus, and pulmonary tuberculosis. At the time of onset, she was receiving corticosteroid, anabolic steroid, an H{sub 2}-blocker (famotidine), and other medication. Since she developed symptoms of meningitis when she visited our hospital for regular medical check-up for aplastic anemia, she was hospitalized and given antibiotic therapy, including ABPC, without delay. With this effective antibiotic therapy and successful management of the co-existing medical conditions, she was cured except for being a little euphoric. Lm meningitis is known to occur in aged and immunocompromised patients. Since most of the atomic bomb survivors are now aged and the prevalence of malignancy, diabetes mellitus, and other diseases which cause immunodeficiency have been rising year by year, Lm meningitis is one of the emergency neurologic conditions whose diagnosis should not be delayed in this population. (author).

  6. Did the Allies Know in 1942 About Nazi Germany's Poor Prospects for an Atomic Bomb?

    Science.gov (United States)

    Lustig, Harry

    2008-04-01

    According to official accounts, the U.S. knew nothing about Nazi Germany's efforts to get an atomic bomb until the end of the World War II, but had feared the worst. As it turned out, the Germans had made little progress. But did someone in the Allied camp know in 1942? In his 1986 book, The Griffin, Arnold Kramish relates how Paul Rosbaud, a spy for MI6, the British secret intelligence service, kept his handlers informed during the War about the German atomic project and reported the decision to give up on a bomb. Kramish's revelations are, understandably, thinly documented and Rosbaud's name can hardly be found independenly anywhere else. But as Samuel Goudsmit's papers in the Bohr Library show, he knew and communicated with Rosbaud from August 1945 on. In 1986, 15 letters exchanged by Goudsmit and Rosbaud were removed by the Government from the Library and eventually placed in the National Archives under classification review. Renewed interest in the Rosbaud story was engendered last year when his family sued MI6 in an English court for the release of the Rosbaud file. So far the spy agency has refused to reveal even that there is such a file. Discovering authoritatively what Rosbaud told the British and what they did with the information is clearly of historical interest.

  7. Experimental patients of drug treatment for cataracta in the persons exposed to an atomic bomb near the explosion

    International Nuclear Information System (INIS)

    Sugimoto, Shigenori

    1976-01-01

    This paper describes the clinical process of 4 persons exposed to an atomic bomb near the explosion in Nagasaki who have received chemotherapy because of incipient senile cataracta associated by cataracta due to an atomic bomb. The dropping of Catalin and Tathion in the eyes, oral administration of Thiola, and injection of Glutathione were done. Dramatic results were not obtained. However, when the administration was done at the time of slight corneal opacity, it did not developed. Therefore, it can't be denied now that the chemotherapy is effective. (Kanao, N.)

  8. Role of neutrons in late effects of radiation among A-Bomb survivors

    International Nuclear Information System (INIS)

    Beebe, Gilbert W.; Land, Charles E.; Jablon, Seymour

    1978-01-01

    Experimental findings of many kinds as well as the Rossi-Kellerer theory of dual radiation action suggest that neutrons and gamma rays may differ in their biological effects, especially carcinogenesis, upon man. In particular, for many but not necessarily all cancers the carcinogenic effect of neutrons may be linear, and that of gamma- or X-radiation, a more complex function with linear and quadratic terms; in addition, dose-response functions for both types of radiation probably require a modifying factor to account for the frequently observed turn-down of dose-response curves in the high-dose region. In a further analysis of leukemia among A-Bomb survivors, Ishimaru et al. have fitted the function y a 0 + a 1 n + a 2 γ 2 where the a's are constants and n and γ the respective neutron and gamma doses. They find not only that this function fits the data well, although not significantly better than a straight line, but also that the best estimate of relative biological effectiveness (RBE) for neutrons is 44n -1/2 . In the present paper we report our efforts to re-analyze ABCC-RERF data on a variety of late radiation effects in an effort to distinguish between neutron and gamma radiation more sharply than has been possible in the past. The effects examined include: chromosomal aberrations, small heads and mental retardation, leukemia, thyroid cancer, lung cancer, breast cancer, stomach cancer, esophageal cancer, lymphomas. The results of fitting various models will be reported. Goodness of fit will be examined and efforts will be made to derive RBE estimates. (author)

  9. Primary intracranial tumors among atomic bomb survivors and controls, Hiroshima and Nagasaki, 1961-75

    International Nuclear Information System (INIS)

    Seyama, Shinichi; Ishimaru, Toranosuke; Iijima, Soichi; Mori, Kazuo.

    1980-02-01

    An analysis was made of the relationship of radiation dose to the occurrence of primary intracranial tumors among atomic bomb survivors and nonexposed controls, Hiroshima and Nagasaki, in the fixed cohort of the Life Span Study (LSS) extended sample during the period 1961-75, or 16 to 30 years after the A-bombs. Based on various medical sources, 104 cases of primary intracranial tumors were identified among approximately 99,000 LSS extended sample members who were alive as of 1 January 1961. Of these 104 cases, 45 had manifested clinical signs of brain tumors, but, 59 cases were identified incidentally at postmortem examination. The distributions of morphologic type, age, and size of tumor were quite different for those primary intracranial tumors with and without a clinical sign of brain tumor. Glioma was the most frequent type of tumor with a clinical sign and meningioma was the most frequent type without. In relation to radiation dose the incidence rate of primary intracranial tumors with a clinical sign showed a significant excess risk for males in the high dose group who received 100 rad or more after adjustment for age at the time of the bomb (ATB). The standardized relative risk is around 5 in this group. The data also suggest that the crude relative risk of glioma is greater in the high dose group for younger ages ATB. However, there is no increased risk in females. Among the 5,012 autopsy subjects in the LSS extended sample during 1961-75, there is no relationship between radiation dose and the prevalence rate of primary intracranial tumors in those identified incidentally by autopsy. The relative risk of subclinical adenoma of the pituitary gland between high dose subjects and controls was also examined for a sample of 95 sex- and age-matched pairs using Hiroshima autopsy materials for 1961-74, but no relationship to dose was observed. (author)

  10. Circulating Hematopoietic Stem and Progenitor Cells in Aging Atomic Bomb Survivors.

    Science.gov (United States)

    Kyoizumi, Seishi; Kubo, Yoshiko; Misumi, Munechika; Kajimura, Junko; Yoshida, Kengo; Hayashi, Tomonori; Imai, Kazue; Ohishi, Waka; Nakachi, Kei; Young, Lauren F; Shieh, Jae-Hung; Moore, Malcolm A; van den Brink, Marcel R M; Kusunoki, Yoichiro

    2016-01-01

    It is not yet known whether hematopoietic stem and progenitor cells (HSPCs) are compromised in the aging population of atomic bomb (A-bomb) survivors after their exposure nearly 70 years ago. To address this, we evaluated age- and radiation-related changes in different subtypes of circulating HSPCs among the CD34-positive/lineage marker-negative (CD34(+)Lin(-)) cell population in 231 Hiroshima A-bomb survivors. We enumerated functional HSPC subtypes, including: cobblestone area-forming cells; long-term culture-initiating cells; erythroid burst-forming units; granulocyte and macrophage colony-forming units; and T-cell and natural killer cell progenitors using cell culture. We obtained the count of each HSPC subtype per unit volume of blood and the proportion of each HSPC subtype in CD34(+)Lin(-) cells to represent the lineage commitment trend. Multivariate analyses, using sex, age and radiation dose as variables, showed significantly decreased counts with age in the total CD34(+)Lin(-) cell population and all HSPC subtypes. As for the proportion, only T-cell progenitors decreased significantly with age, suggesting that the commitment to the T-cell lineage in HSPCs continuously declines with age throughout the lifetime. However, neither the CD34(+)Lin(-) cell population, nor HSPC subtypes showed significant radiation-induced dose-dependent changes in counts or proportions. Moreover, the correlations of the proportions among HSPC subtypes in the survivors properly revealed the hierarchy of lineage commitments. Taken together, our findings suggest that many years after exposure to radiation and with advancing age, the number and function of HSPCs in living survivors as a whole may have recovered to normal levels.

  11. Public health nutritional studies on the atomic bomb female survivors living in Hiroshima

    Energy Technology Data Exchange (ETDEWEB)

    Munaka, Masaki; Yamamoto, Hisashi; Ohtaki, Megu; Ueoka, Hiroshi (Hiroshima Univ. (Japan). Research Inst. for Nuclear Medicine and Biology); Kishida, Noriko; Ishigai, Keiko

    1982-09-01

    The atomic bomb survivors group exposed at a long distance (LDG) was found to take a great quantity of soybean curd, miso and fruit except citrus, while the atomic bomb survivors group exposed at a short distance (SDG) was found to take a significant amount of fish paste product. SDG tends to ingest processed food and in nutrient supply rate the percentage of calcium, iron and vitamin A is low. Judging from a state of food group without a meal rate, we got the result that SDG has a few kinds of ingestion food and takes them partially in each meal. In terms of socio-economic status, the rate of living alone, supporting oneself and living an empty life is high and the rate of living with a partner is low. On the other hand, we analysed the relations of three factors on physique-physical fitness and living status, and then got the following results. (1) ''Volume capacity'', in the cases of ''be married at present'', ''have a large family'', ''ingest a lot of protein and iron'', tends to be large, while in the cases of ''have no disease'', ''don't go without a meal'', ''ingest a lot of carbohydrates (non-fibrous)'', and ''nutritional balance is good'', it tends to be small. (2) ''Height'', in the case of ''socio-economical status was good before exposure to the atomic bomb'', tends to increase. (3) ''Synthetic physical fitness'', in the cases of ''health condition is good at present'', ''have no disease at present'', ''ingest a lot of vitamin A'' and ''nutritional balance is good'', tends to be superior; in the cases of ''food cost is high'' and ''ingest a lot of carbohydrates (non-fibrous)'', it tends to be low. The significant

  12. Search for mutations altering protein charge and/or function in children of atomic bomb survivors: final report

    International Nuclear Information System (INIS)

    Neel, J.V.; Satoh, Chiyoko; Goriki, Kazuaki; Asakawa, Jun-ichi; Fujita, Mikio; Takahashi, Norio; Kageoka, Takeshi; Hazama, Ryuji.

    1990-04-01

    A sample of children whose parents were proximally exposed at the time of the atomic bombings of Hiroshima and Nagasaki (i.e., within 2,000 m of the hypocenter) and a suitable comparison group have been examined for the occurrence of mutations altering the electrophoretic mobility or activity of a series of 30 proteins. The examination of the equivalent of 667,404 locus products in the children of proximally exposed persons yielded three mutations altering electrophoretic mobility; the corresponding figure for the comparison group was three mutations in 466,881 tests. The examination of a subset of 60,529 locus products for loss of enzyme activity in the children of proximally exposed persons yielded one mutation; no mutations were encountered in 61,741 determinations on the children of the comparison group. Combining these two series, the mutation rate observed in the children of proximally exposed is thus 0.60 x 10 -5 /locus/generation, with 95 % confidence intervals between 0.2 and 1.5 x 10 -5 , and in the comparison children, 0.64 x 10 -5 /locus/generation, with 95 % intervals between 0.1 and 1.9 x 10 -5 . The average conjoint gonad doses of the proximally exposed parents are estimated to be 0.437 Gy of gamma radiation and 0.002 Gy of neutron radiation. Assigning a relative biological effectiveness of 20 to the neutron radiation, the combined total gonad dose of the parents becomes 0.477 Sv. (author)

  13. Ending the War against Japan: Science, Morality, and the Atomic Bomb. Choices for the 21st Century.

    Science.gov (United States)

    Bakker, Don

    This unit presents students with dilemmas faced by U.S. policymakers with three distinct options for U.S. policy toward Japan. Background readings provide students with information on the U.S. decision to drop the atomic bomb on Japan in 1945. By exploring a spectrum of alternatives, students gain a deeper understanding of the values underlying…

  14. T and B cells and PHA response of peripheral lymphocytes among atomic bomb survivors

    International Nuclear Information System (INIS)

    Yamakido, Michio; Akiyama, Mitoshi; Dock, D.S.; Hamilton, H.B.; Awa, A.A.

    1982-07-01

    Little is known about immune compretence in atomic bomb survivors. The following results were observed from this study. T and B cells showed no change in proportion by age or exposure dose. The percentage of T cells was slightly lower in malignant tumor patients than in the control group. However, it was significantly higher in the group with chromosomal aberrations than in the control group. Phytohemagglutinin (PHA) response of peripheral lymphocytes decreased significantly with age in the 0 rad control group and the 200+ rad exposure group, particularly so in the latter. The malignant tumor group also showed lower PHA response than the control group. The PHA response of the chromosomal aberration group was significantly depressed compared with that of the control group. (author)

  15. Some effects of random dose measurement errors on analysis of atomic bomb survivor data

    International Nuclear Information System (INIS)

    Gilbert, E.S.

    1985-01-01

    The effects of random dose measurement errors on analyses of atomic bomb survivor data are described and quantified for several procedures. It is found that the ways in which measurement error is most likely to mislead are through downward bias in the estimated regression coefficients and through distortion of the shape of the dose-response curve. The magnitude of the bias with simple linear regression is evaluated for several dose treatments including the use of grouped and ungrouped data, analyses with and without truncation at 600 rad, and analyses which exclude doses exceeding 200 rad. Limited calculations have also been made for maximum likelihood estimation based on Poisson regression. 16 refs., 6 tabs

  16. Malignant tumors during the first 2 decades of life in the offspring of atomic bomb survivors

    International Nuclear Information System (INIS)

    Yoshimoto, Y.; Neel, J.V.; Schull, W.J.; Kato, H.; Soda, M.; Eto, R.; Mabuchi, K.

    1990-01-01

    The risk of cancer (incidence) prior to age 20 years has been determined for children born to atomic bomb survivors and to a suitable comparison group. Tumor ascertainment was through death certificates and the tumor registries maintained in Hiroshima and Nagasaki. The rationale for the study stemmed from the evidence that a significant proportion of such childhood tumors as retinoblastoma and Wilms tumor arise on the basis of a mutant gene inherited from one parent plus a second somatic cell mutation involving the allele of this gene. Gonadal radiation doses were calculated by the recently established DS86 system, supplemented by an ad hoc system for those children for one or both of whose parents a DS86 dose could not be computed but for whom an ad hoc dose could be developed on the basis of the available information. The total data set consisted of (1) a cohort of 31,150 live-born children one or both of whose parents received greater than 0.01 Sv of radiation at the time of the atomic bombings (average conjoint gonad exposure 0.43 Sv) and (2) two suitable comparison groups totaling 41,066 children. Altogether, 43 malignant tumors were ascertained in the children of exposed parents, and 49 malignant tumors were ascertained in the two control groups. A multiple linear regression analysis revealed no increase in malignancy in the children of exposed parents. However, examination of the data suggested that only 3.0-5.0% of the tumors of childhood that were observed in the comparison groups are associated with an inherited genetic predisposition that would be expected to exhibit an altered frequency if the parental mutation rate were increased. There is thus far no confirmation of the positive findings that Nomura found in a mouse system

  17. Differential effects of atomic bomb irradiation in inducing major leukemia types

    International Nuclear Information System (INIS)

    Tomonaga, Masao; Matsuo, Tatsuki; Carter, R.L.

    1993-05-01

    In this report we utilize data from the additional 517 cases from the leukemia registry together with the Life Span Study (LSS) cohort data to study the effects of atomic bomb irradiation on major leukemia types. The French-American-British classification and other improved diagnostic methods were used to reclassify cases into 21 categories, including new disease entities such as adult T-cell leukemia (ATL). These categories were then grouped into four major types for analysis: (1) acute lymphocytic leukemia (ALL), (2) acute myeloid leukemia (AML) including myelodysplastic syndromes (MDS), (3) chronic myeloid leukemia (CML), and (4) OTHER types including ATL. Analyses of radiation effects were based on the updated Dosimetry System 1986(DS86). Incidence rates of all four leukemia types increased with increasing exposure level. The effects of radiation were significantly greater on the incidence of ALL and CML than on that of AML and OTHER. In the two lowest dose categories (1-49 and 50-499 mGy), estimated incidence either remained constant or increased slightly as the population of survivors aged. In the two highest dose categories (500-1,499 and ≥ 1,500 mGy). Among unexposed persons, the estimated risk of CML in Nagasaki relative to Hiroshima was significantly less than that of AML, whereas that of OTHER types was significantly greater. The time to onset of ALL, AML, and CML declined with increasing dose. The rate of decline, however, was greater for ALL and CML than for AML. The resulting differences at high doses reflect shorter incubation times for atomic-bomb-induced ALL and CML than for AML. (J.P.N.)

  18. Bomb parameters

    International Nuclear Information System (INIS)

    Kerr, George D.; Young, Rebert W.; Cullings, Harry M.; Christry, Robert F.

    2005-01-01

    The reconstruction of neutron and gamma-ray doses at Hiroshima and Nagasaki begins with a determination of the parameters describing the explosion. The calculations of the air transported radiation fields and survivor doses from the Hiroshima and Nagasaki bombs require knowledge of a variety of parameters related to the explosions. These various parameters include the heading of the bomber when the bomb was released, the epicenters of the explosions, the bomb yields, and the tilt of the bombs at time of explosion. The epicenter of a bomb is the explosion point in air that is specified in terms of a burst height and a hypocenter (or the point on the ground directly below the epicenter of the explosion). The current reassessment refines the energy yield and burst height for the Hiroshima bomb, as well as the locations of the Hiroshima and Nagasaki hypocenters on the modern city maps used in the analysis of the activation data for neutrons and TLD data for gamma rays. (J.P.N.)

  19. A survey of radiation doses received by atomic-bomb survivors residing in the U.S

    International Nuclear Information System (INIS)

    Kerr, G.D.; Yamada, H.; Marks, S.

    1976-01-01

    A survey has been completed of 300 of an estimated 500 to 750 survivors of the atomic bombings in Hiroshima and Nagasaki who reside in the U.S. Distributions with respect to age, sex, citizenship status, distance from the hypocenter at the time of bombing, and dose from immediate weapon radiation have been tabulated from the results and are presented for this group of 300 survivors. Also presented are survey results concerning exposures to residual radiation from fallout and neutral-induced radioactivity in the areas adjacent to the hypocenter. (author)

  20. Significance of genomic instability in breast cancer in atomic bomb survivors: analysis of microarray-comparative genomic hybridization

    International Nuclear Information System (INIS)

    Oikawa, Masahiro; Yoshiura, Koh-ichiro; Kondo, Hisayoshi; Miura, Shiro; Nagayasu, Takeshi; Nakashima, Masahiro

    2011-01-01

    It has been postulated that ionizing radiation induces breast cancers among atomic bomb (A-bomb) survivors. We have reported a higher incidence of HER2 and C-MYC oncogene amplification in breast cancers from A-bomb survivors. The purpose of this study was to clarify the effect of A-bomb radiation exposure on genomic instability (GIN), which is an important hallmark of carcinogenesis, in archival formalin-fixed paraffin-embedded (FFPE) tissues of breast cancer by using microarray-comparative genomic hybridization (aCGH). Tumor DNA was extracted from FFPE tissues of invasive ductal cancers from 15 survivors who were exposed at 1.5 km or less from the hypocenter and 13 calendar year-matched non-exposed patients followed by aCGH analysis using a high-density oligonucleotide microarray. The total length of copy number aberrations (CNA) was used as an indicator of GIN, and correlation with clinicopathological factors were statistically tested. The mean of the derivative log ratio spread (DLRSpread), which estimates the noise by calculating the spread of log ratio differences between consecutive probes for all chromosomes, was 0.54 (range, 0.26 to 1.05). The concordance of results between aCGH and fluorescence in situ hybridization (FISH) for HER2 gene amplification was 88%. The incidence of HER2 amplification and histological grade was significantly higher in the A-bomb survivors than control group (P = 0.04, respectively). The total length of CNA tended to be larger in the A-bomb survivors (P = 0.15). Correlation analysis of CNA and clinicopathological factors revealed that DLRSpread was negatively correlated with that significantly (P = 0.034, r = -0.40). Multivariate analysis with covariance revealed that the exposure to A-bomb was a significant (P = 0.005) independent factor which was associated with larger total length of CNA of breast cancers. Thus, archival FFPE tissues from A-bomb survivors are useful for genome-wide aCGH analysis. Our results suggested that A-bomb

  1. Radiation risk of individual multifactorial diseases in offspring of the atomic-bomb survivors: a clinical health study

    International Nuclear Information System (INIS)

    Tatsukawa, Yoshimi; Yamada, Michiko; Ohishi, Waka; Hida, Ayumi; Akahoshi, Masazumi; Fujiwara, Saeko; Cologne, John B; Hsu, Wan-Ling; Furukawa, Kyoji; Takahashi, Norio; Nakamura, Nori; Suyama, Akihiko; Ozasa, Kotaro; Shore, Roy

    2013-01-01

    There is no convincing evidence regarding radiation-induced heritable risks of adult-onset multifactorial diseases in humans, although it is important from the standpoint of protection and management of populations exposed to radiation. The objective of the present study was to examine whether parental exposure to atomic-bomb (A-bomb) radiation led to an increased risk of common polygenic, multifactorial diseases—hypertension, hypercholesterolaemia, diabetes mellitus, angina pectoris, myocardial infarction or stroke—in the first-generation (F 1 ) offspring of A-bomb survivors. A total of 11 951 F 1 offspring of survivors in Hiroshima or Nagasaki, conceived after the bombing, underwent health examinations to assess disease prevalence. We found no evidence that paternal or maternal A-bomb radiation dose, or the sum of their doses, was associated with an increased risk of any multifactorial diseases in either male or female offspring. None of the 18 radiation dose–response slopes, adjusted for other risk factors for the diseases, was statistically significantly elevated. However, the study population is still in mid-life (mean age 48.6 years), and will express much of its multifactorial disease incidence in the future, so ongoing longitudinal follow-up will provide increasingly informative risk estimates regarding hereditary genetic effects for incidence of adult-onset multifactorial disease. (paper)

  2. Radiation risk of individual multifactorial diseases in offspring of the atomic-bomb survivors: a clinical health study.

    Science.gov (United States)

    Tatsukawa, Yoshimi; Cologne, John B; Hsu, Wan-Ling; Yamada, Michiko; Ohishi, Waka; Hida, Ayumi; Furukawa, Kyoji; Takahashi, Norio; Nakamura, Nori; Suyama, Akihiko; Ozasa, Kotaro; Akahoshi, Masazumi; Fujiwara, Saeko; Shore, Roy

    2013-06-01

    There is no convincing evidence regarding radiation-induced heritable risks of adult-onset multifactorial diseases in humans, although it is important from the standpoint of protection and management of populations exposed to radiation. The objective of the present study was to examine whether parental exposure to atomic-bomb (A-bomb) radiation led to an increased risk of common polygenic, multifactorial diseases-hypertension, hypercholesterolaemia, diabetes mellitus, angina pectoris, myocardial infarction or stroke-in the first-generation (F1) offspring of A-bomb survivors. A total of 11,951 F1 offspring of survivors in Hiroshima or Nagasaki, conceived after the bombing, underwent health examinations to assess disease prevalence. We found no evidence that paternal or maternal A-bomb radiation dose, or the sum of their doses, was associated with an increased risk of any multifactorial diseases in either male or female offspring. None of the 18 radiation dose-response slopes, adjusted for other risk factors for the diseases, was statistically significantly elevated. However, the study population is still in mid-life (mean age 48.6 years), and will express much of its multifactorial disease incidence in the future, so ongoing longitudinal follow-up will provide increasingly informative risk estimates regarding hereditary genetic effects for incidence of adult-onset multifactorial disease.

  3. Hepatitis virus infection and chronic liver disease among atomic-bomb survivors

    Energy Technology Data Exchange (ETDEWEB)

    Fujiwara, S.; Cologne, J.; Akahoshi, M. [Radiation Effects Research Foundation, Hiroshima (Japan); Kusumi, S.; Kodama, K.; Yoshizawa, H.

    2000-05-01

    The purpose of this study is to analyze various laboratory indicators of inflammation measured in atomic bomb survivors. Subjects are 6304 survivors who underwent inflammatory tests at RERF between 1998 and 1992 and whose radiation doses (DS86) are available. Inflammatory tests include leukocyte counts, neutrophil counts, erythrocyte sedimentation rate, corrected erythrocyte sedimentation rate, alpha 1 globulin, alpha 2 globulin, and sialic acid. Adjusting for age, sex, smoking, and city of residence, regression analysis was conducted. Regression analysis, adjusted for age, sex, smoking, and city of residence showed statistically significant associations with radiation dose for leukocyte counts (71.0 /mm{sup 3}/Gy, p=0.00151), erythrocyte sedimentation rate (1.58 mm/hour/Gy, p=0.0001), corrected erythrocyte sedimentation rate (1.14 mm/hour/Gy, p=0.0001), alpha 1 globulin (0.0057 g/dl/Gy, p=0.0001), alpha 2 globulin (0.0128 g/dl/Gy, p=0.0001), and sialic acid (1.2711 mg/dl/Gy, p=0.0001), but not for neutrophil counts (29.9 /mm{sup 3}/Gy, p=0.1729). Standardized scores combining results from these seven inflammatory tests showed significant associations with radiation dose both for persons with and without inflammatory disease, and for two inflammatory conditions in particular, chronic thyroiditis and chronic liver disease. In analyses of data from 403 AHS patients, in whom both inflammation indicators and T-cell ratios were measured, increased inflammation correlates with decreases in CD4 T-cells. Since the laboratory indicators of inflammation that we studied are not specific for particular clinical diseases, the implication of their dose-response-pattern is hard to interpret. The general occurrence of infectious diseases in survivors is not related to radiation dose. Such a relationship does exist, however, for other diseases in which infection may play an etiologic role. Virologic studies in A-bomb survivors have suggested dose-response alterations in immune

  4. Radiation-related ophthalmologic changes and aging among the atomic bomb survivors

    International Nuclear Information System (INIS)

    Otake, Masanori; Finch, S.C.; Choshi, Kanji; Takaku, Isao; Mishima, Hiromu; Takase, Tomoko.

    1993-05-01

    The relationship of ionizing radiation to the age-related ophthalmologic findings of the 1978-80 ophthalmologic examination of the atomic bomb (A-bomb) survivors of Hiroshima and Nagasaki has been reanalyzed using Dosimetry System 1986 eye organ dose estimates. The main purpose of this re-evaluation was to determine whether age and radiation exposure have an additive, synergistic, or antagonistic effect on ophthalmologic changes. The best model fitting axial opacities gives a significant positive effect for both linear dose-response and linear age-related regression coefficients and a significant negative effect for an interaction between radiation dose and age. Such a negative interaction implies an antagonistic effect in that the relative risks with relation to radiation doses decrease with increasing age. This phenomenon suggests that the lenses of younger persons are more sensitive to radiation than are those of older persons. However, the best-fitting relationship for posterior subcapsular changes suggested a linear-quadratic dose response and linear age-related effects. The quadratic estimate of radiation dose squared showed a highly significant effect with a negative trend, but the negative quadratic estimate was so extremely small it had almost no contributive value within an appropriative dose area. These data suggest an additive relationship between aging and radiation for the induction of posterior subcapsular changes, and they also indicate that there is no distinct evidence of a radiation-induced aging effect. The radiation-related relative risks increase with a log linearity. The decrease of visual acuity and accommodation with increasing age were comparable in both exposed and control subjects, with age-related visual acuity decreasing more than accommodation. (J.P.N.)

  5. Dose-response relationship of leukemia incidence among atomic bomb survivors and their controls by absorbed marrow dose and two types of leukemia Hiroshima and Nagasaki, October 1950 - December 1978

    International Nuclear Information System (INIS)

    Ishimaru, Toranosuke; Otake, Masanori; Ichimaru, Michito; Mikami, Motoko.

    1982-07-01

    Analysis of the relationship of the incidence of leukemia to gamma and neutron dose among atomic bomb survivors until 1971 has been reported previously by RERF. The present inquiry was prompted by the extension of case finding to 1978 and by the recent availability of new dose estimates for this fixed cohort. It is focused on the relationship of absorbed marrow dose of gamma rays and neutrons to the incidence of two types of leukemia in the fixed cohort of A-bomb survivors and their controls, the Life Span Study extended sample, in the period October 1950-December 1978. Three dose-response models have been fitted to the data on acute leukemia and chronic granulocytic leukemia. The relationship of the incidence of acute leukemia to gamma and neutron dose again suggests that the ''best'' fitting model involves a dependence on the square of the gamma dose and a linear dependence on neutrons. The estimated relative biological effectiveness (RBE) of neutrons in the induction of acute leukemia is approximately 44/√Dn(Dn = neutron dose) under this model. Based on the 95% confidence limits of the estimated RBE, the risk of this disease is estimated as 0.0026 - 0.0072 cases per million person-years per rem 2 of marrow dose. This analysis has failed, however, to produce a significant dose-response function for the incidence of chronic granulocytic leukemia in relation to the two kinds of radiation. (author)

  6. Hepatitis virus infection and chronic liver disease among atomic-bomb survivors

    Energy Technology Data Exchange (ETDEWEB)

    Fujiwara, Saeko; Cologne, John; Akahoshi, Masazumi [Radiation Effects Research Foundation, Hiroshima (Japan); Kusumi, Shizuyo [Institute of Radiation Epidemiology, Radiation Effects Association, Tokyo (Japan); Kodama, Kazunori; Yoshizawa, Hiroshi [Hiroshima University School of Medicine, Hiroshima (Japan)

    2000-05-01

    Hepatitis C and B virus (HCV, HBV) infection plays a crucial role in the etiology of chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma, which have been reported to increase with radiation dose among the atomic bomb survivors. The purpose of this study is to investigate whether radiation exposure altered the prevalence of hepatitis virus infection or accelerated the progress toward chronic hepatitis after hepatitis virus infection. Levels of serum antibody to hepatitis C virus (anti-HCV), HBs antigen (HBsAg), and anti-HBs antibody (anti-HBs) were measured for 6,121 participants in the Adult Health Study of atomic bomb survivors in Hiroshima and Nagasaki. No relationship was found between anti-HCV prevalence and radiation dose, after adjusting for age, sex, city, history of blood transfusion, acupuncture, and family history, but prevalence of anti-HCV was significantly lower overall among the radiation-exposed people (relative prevalence 0.84, p=0.022) compared to people with estimated radiation dose 0 Gy. No significant interaction was found between any of the above mentioned risk factors and radiation dose. People with anti-HCV positive had 13 times higher prevalence of chronic liver disease than those without anti-HCV. However, the radiation dose response for chronic liver disease among anti-HCV positive survivors may be greater than that among anti-HCV negative survivors (slope ratio 20), but the difference was marginally significant (p=0.097). Prevalence of HBsAg increased with whole-body kerma. However, no trend with radiation dose was found in the anti-HBs prevalence. In the background, prevalence of chronic liver disease in people with HBsAg-positive was approximately three times higher that in those without HBsAg. No difference in slope of the dose was found among HBsAg positive and negative individuals (slope: HBsAg positive 0.91/Gy, HBsAg negative 0.11/Gy, difference p=0.66). In conclusion, no dose-response relationship was found between

  7. Hepatitis virus infection and chronic liver disease among atomic-bomb survivors

    International Nuclear Information System (INIS)

    Fujiwara, Saeko; Cologne, John; Akahoshi, Masazumi; Kusumi, Shizuyo; Kodama, Kazunori; Yoshizawa, Hiroshi

    2000-01-01

    Hepatitis C and B virus (HCV, HBV) infection plays a crucial role in the etiology of chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma, which have been reported to increase with radiation dose among the atomic bomb survivors. The purpose of this study is to investigate whether radiation exposure altered the prevalence of hepatitis virus infection or accelerated the progress toward chronic hepatitis after hepatitis virus infection. Levels of serum antibody to hepatitis C virus (anti-HCV), HBs antigen (HBsAg), and anti-HBs antibody (anti-HBs) were measured for 6,121 participants in the Adult Health Study of atomic bomb survivors in Hiroshima and Nagasaki. No relationship was found between anti-HCV prevalence and radiation dose, after adjusting for age, sex, city, history of blood transfusion, acupuncture, and family history, but prevalence of anti-HCV was significantly lower overall among the radiation-exposed people (relative prevalence 0.84, p=0.022) compared to people with estimated radiation dose 0 Gy. No significant interaction was found between any of the above mentioned risk factors and radiation dose. People with anti-HCV positive had 13 times higher prevalence of chronic liver disease than those without anti-HCV. However, the radiation dose response for chronic liver disease among anti-HCV positive survivors may be greater than that among anti-HCV negative survivors (slope ratio 20), but the difference was marginally significant (p=0.097). Prevalence of HBsAg increased with whole-body kerma. However, no trend with radiation dose was found in the anti-HBs prevalence. In the background, prevalence of chronic liver disease in people with HBsAg-positive was approximately three times higher that in those without HBsAg. No difference in slope of the dose was found among HBsAg positive and negative individuals (slope: HBsAg positive 0.91/Gy, HBsAg negative 0.11/Gy, difference p=0.66). In conclusion, no dose-response relationship was found between

  8. Chromosome aberrations and oncogene alterations in atomic bomb related leukemias - different mechanisms from de novo leukemias

    International Nuclear Information System (INIS)

    Tanaka, K.; Tanaka, H.; Kamada, N.

    2003-01-01

    It is well known that leukemia occurred more frequently among atomic bomb survivors. In 132 atomic bomb related ( AB- related) leukemia patients during 1978-1999, 33 acute myeloid leukemia (AML)/myelodysplastic syndrome (MDS) patients had their exposure doses of more than 1Gy (DS86). Chromosome aberrations of the 33 patients were compared with those from 588 de novo AML/MDS patients who had been bone before August 1945 as control. No FAB M3 patient was observed in the exposed group. Most AB-related AML preceded a long term of MDS stage. Twenty seven of the 33 patients showed complex types of chromosome aberrations with more than three chromosomes involving chromosomes 5,7 and 11. The number of chromosomes abnormality per cell in the AB-related leukemia was 3.78 while 0.92 in de novo leukemia. Only one of the 33 patients had normal karyotype, while 44.1% in de novo leukemia patients. Translocations of chromosome 11 at 11q13 to 11q23 and deletion/ loss of chromosome 20 were frequently observed in AB-related leukemia. No leukemia-type specific translocations such as t(8;21),t(15;17) and 11q23 were found in the 33 AB-related leukemia patients. Furthermore, molecular analyses using FISH and PCR-SSCP revealed the presence of breakpoint located outside of MLL gene in the patients with translocations at 11q22-23 and DNA base derangements of RUNT domain of AML1(CBF β 2)gene with AML/MDS patients without t(8;21) and with a high dose of exposure. These results suggest that AB-related leukemia derives from an exposed pluripotent hematopoietic stem cell which has been preserved for a long time in the bone marrow, expressing high genetic instability such as microsatellite instability. On the other hand, de novo leukemia develops from a committed hematopoietic stem cell and shows simple and leukemia-type specific chromosome aberrations. These findings are important for understanding mechanisms for radiation-induced leukemia

  9. Magnetic scattering of neutrons by atoms

    International Nuclear Information System (INIS)

    Stassis, C.; Deckman, H.W.

    1976-01-01

    The magnetic scattering of neutrons by an atom or ion possessing both a spin and orbital magnetic moment is examined. For an atom in the 1sup(n) electronic configuration the magnetic scattering amplitude is determined by matrix elements of even-order electric and odd-order magnetic multipoles, whose order of multipolarity k is less than or equal to 21 + 1. The calculation of the matrix elements of these multipoles is separated into evaluating radial matrix elements and matrix elements of the Racah tensors Wsup(0,k) and Wsup(1,k') where k is an even integar less than or equal to 21. The calculation of the matrix elements of these tensors is considerably simplified by selection rules based on the groups Sp(41 + 2), R(21 + 1), R(3) and in the case of f-electrons, the special group G 2 . It is shown that, in the case of elastic scattering by an atom or an ion whose state is a single Russell-Saunders state, the magnetic scattering amplitude can be written in the conventional form p(q)qsub(m).sigma. General expressions for the amplitude p(q) as well as the elastic magnetic form factor are obtained. The evaluation of the coherent magnetic scattering amplitude by an atom in a magnetic field is discussed, and the small-q approximation to the elastic magnetic scattering is considered. The formation is illustrated for the important case of d- and f-electrons. The generalization of the formalism to the case of mixed atomic configurations is examined in some detail. (author)

  10. A search for mutations affecting protein structure in children of proximally and distally exposed atomic bomb survivors

    International Nuclear Information System (INIS)

    Neel, J.V.; Satoh, Chiyoko; Hamilton, H.B.; Otake, Masanori; Goriki, Kazuaki; Kageoka, Takeshi; Fujita, Mikio; Neriishi, Shotaro; Asakawa, Jun-ichi.

    1981-07-01

    A total of 289,868 locus tests based on 28 different protein phenotypes, employing one-dimensional electrophoresis to detect variant proteins, has yielded one probable mutation in the offspring of 'proximally exposed' parents, who received an estimated average gonadal exposure dose of between 31 and 39 rem from the atomic bombs in Hiroshima and Nagasaki. There were no mutations in 208,196 locus tests involving children of 'distally exposed' parents, who had essentially no radiation exposure. (author)

  11. The articles on atomic bomb of the newspaper in the past 15 years

    International Nuclear Information System (INIS)

    Ubuki, Satoru; Hayakawa, Norihiko; Matsuura, Masaaki; Hatano, Hiroko

    1990-01-01

    A-bomb hazards are given publicity by journalism every year from the end of the 1960s, especially in July and August, in Japan. This is generally termed 'the publication of A-bomb articles'. This paper outlines 'the publication of A-bomb articles' and introduces the actual conditions of A-bomb hazard problems. Articles were selected from three major national newspapers and two domestic newspapers (Hiroshima and Nagasaki) during the past 15 years from 1975 through 1989. Contents of the articles were divided into 20 categories and subdivided into 92 categories. According to newspaper, the Hiroshima domestic newspaper published the articles in the largest number (approximately 30% of all the articles). Overall, approximately 21% of the articles were published in August. The most common article content was A-bomb survivors' experiences, accounting for 47% before 1981 and 60% since 1982. (N.K.)

  12. Leukemia incidence in the atomic bomb survivor Life Span Study, 1950 - 87

    International Nuclear Information System (INIS)

    Preston, D.L.; Mabuchi, K.; Kusumi, S.; Izumi, S.

    1992-01-01

    The Radiation Effects Research Foundation (RERF) is currently preparing a series of reports on cancer incidence in the Life Span Study (LSS) cohort of atomic bomb survivors for the period from 1950 to 1987. One of these reports will present analyses of the data on the risk of hematopoietic cancers including leukemia, malignant lymphoma, and multiple myeloma. These analyses add an additional 11 years of follow-up to the previous comprehensive analysis of the LSS leukemia data. In this presentation, these data are presented and the methods being used modeling the leukemia risks are outlined. An analysis of the leukemia data pooled over subtypes will be used to illustrate these methods. It is shown that the data suggest a non-linear, concave upward dose response and that the temporal pattern of the radiation-induced excess absolute risks (EARs) depends on age-at-exposure and sex. There is no evidence of city differences in the EAR in this pooled analysis. The results suggest that the EARs for the youngest survivors were initially much higher and have declined more rapidly than those for older survivors. The same general pattern is seen both sexes, but the initial peak incidence is somewhat lower and the rate of decline less rapid for women than for men. (author)

  13. Autopsy findings of the first and second filial generations of atomic bomb survivors

    Energy Technology Data Exchange (ETDEWEB)

    Satow, Yukio (Hiroshima Univ. (Japan). Research Inst. for Nuclear Medicine and Biology)

    1992-01-01

    Autopsy findings of 652 fetuses whose parents or one parent were exposed to the Atomic Bomb (F[sub 1]) and 115 fetuses which had one or two grandparents exposed (F[sub 2]) were compared with that of 8570 fetuses whose parents were not exposed (control). The F[sub 1] fetuses have been collected since 1963 and F[sub 2] fetuses since 1971 voluntarily in Hiroshima. The findings were classified according to the types of delivery and to the distances away from the hypocenter where the parents and grandparents were exposed. Many normal cases in the group of artificial abortions and many malformations and pathological findings in the group of spontaneous abortions were found in both groups of F[sub 1] and F[sub 2]. The malformations were cardiovascular, central nervous and urogenital system, quantitatively in that order, in both groups of F[sub 1] and F[sub 2]. Although there were a few cases of cystic kidney and chondrodystrophy which belong to autosomal dominant and osteogenesis imperfecta which belong to autosomal recessive, these cases were not correlated with the distance. Most cases of malformation which belong to the multifactorial inheritance were found in each organ. No peculiar malformation was found in the groups of F[sub 1] and F[sub 2]. (author).

  14. Autopsy findings of the first and second filial generations of atomic bomb survivors

    International Nuclear Information System (INIS)

    Satow, Yukio

    1992-01-01

    Autopsy findings of 652 fetuses whose parents or one parent were exposed to the Atomic Bomb (F 1 ) and 115 fetuses which had one or two grandparents exposed (F 2 ) were compared with that of 8570 fetuses whose parents were not exposed (control). The F 1 fetuses have been collected since 1963 and F 2 fetuses since 1971 voluntarily in Hiroshima. The findings were classified according to the types of delivery and to the distances away from the hypocenter where the parents and grandparents were exposed. Many normal cases in the group of artificial abortions and many malformations and pathological findings in the group of spontaneous abortions were found in both groups of F 1 and F 2 . The malformations were cardiovascular, central nervous and urogenital system, quantitatively in that order, in both groups of F 1 and F 2 . Although there were a few cases of cystic kidney and chondrodystrophy which belong to autosomal dominant and osteogenesis imperfecta which belong to autosomal recessive, these cases were not correlated with the distance. Most cases of malformation which belong to the multifactorial inheritance were found in each organ. No peculiar malformation was found in the groups of F 1 and F 2 . (author)

  15. Report on the results of the ninth medical examination of atomic bomb survivors in South America

    International Nuclear Information System (INIS)

    Ohta, Michiya; Hiyama, Keiko; Matsuo, Kakaru; Yamamoto, Hiroki; Nishida, Masashi; Sasaki, Yoshinobu

    2001-01-01

    The results of the ninth medical examination are reported. Atomic bomb survivors who had emigrated to South America as of November 2000 totaled 180 (153 to Brazil, 4 to Paraguay, 7 to Bolivia, 13 to Argentina, and 3 to Peru). Eighty persons (44.4%) were examined (62 in Brazil, 2 in Paraguay, 6 in Bolivia, 7 in Argentina, and 3 in Peru). The mean age of the males was 71.3 years, and the mean age of the females was 69.7 years. They had hypertension (24.1%), diabetes (10.1%), cancer (8.9%), heart disease (7.6%), and thyroid disease (2.5%). The most common manifestations of illness were fatigue (69.6%), loss of vigor (65.8%), taking medicine (55.7%), and heat intolerance (53.2%). The incident rates of electrocardiographic abnormalities and urine, blood, and biochemical tests abnormalities were almost the same as at the previous examination, and there was no change in the percentage of those who required detailed tests and treatment. When independence in daily life was judged by the criteria of the nursing care insurance system, 68 persons were judged ''independent'', and 7 persons ''handicapped.'' (K.H.)

  16. Analysis of peripheral blood lymphocytes of atomic bomb survivors using monoclonal antibodies

    International Nuclear Information System (INIS)

    Fujiwara, Saeko; Akiyama, Mitoshi; Kobuke, Kyoko; Hakoda, Masayuki; Kyoizumi, Seishi; Ochi, Yoshimichi; Jones, S.L.; Olson, G.B.

    1986-01-01

    In order to study the effects of exposure to atomic bomb radiation on the immune competence of man, the proportions of peripheral blood lymphocyte subsets (subpopulations) were determined by an indirect immunofluorescence antibody assay using monoclonal antibodies and fluorescence microscopy. The study was based on a total of 104 Adult Health Study participants in Hiroshima, including 29 individuals exposed to 100 + rad, 46 exposed to 1 - 99 rad, and 29 0 rad controls. No change in the proportion of Leu-1 positive cells (total T cells) and Leu-2a positive cells (cytotoxic/suppressor T cells) and the ratio of Leu-3a/Leu-2a was observed with age, while Leu-3a positive cells (helper/inducer T cells) decreased with age and HLA-DR positive cells (B cells and monocytes) increased with age, with the differences occurring predominantly in the oldest age group (age > 75). The proportion of HLA-DR positive cells was higher in males, but there was no significant sex difference in the proportions of other cell types and the ratio of Leu-3a/Leu-2a. Radiation exposure did not significantly affect the proportions of Leu-1, Leu-2a, Leu-3a, and HLA-DR positive cells and the ratio of Leu-3a/Leu-2a. No interaction between the effects of age and radiation exposure was demonstrated. (author)

  17. Cancer risk at low doses of ionizing radiation: artificial neural networks inference from atomic bomb survivors.

    Science.gov (United States)

    Sasaki, Masao S; Tachibana, Akira; Takeda, Shunichi

    2014-05-01

    Cancer risk at low doses of ionizing radiation remains poorly defined because of ambiguity in the quantitative link to doses below 0.2 Sv in atomic bomb survivors in Hiroshima and Nagasaki arising from limitations in the statistical power and information available on overall radiation dose. To deal with these difficulties, a novel nonparametric statistics based on the 'integrate-and-fire' algorithm of artificial neural networks was developed and tested in cancer databases established by the Radiation Effects Research Foundation. The analysis revealed unique features at low doses that could not be accounted for by nominal exposure dose, including (i) the presence of a threshold that varied with organ, gender and age at exposure, and (ii) a small but significant bumping increase in cancer risk at low doses in Nagasaki that probably reflects internal exposure to (239)Pu. The threshold was distinct from the canonical definition of zero effect in that it was manifested as negative excess relative risk, or suppression of background cancer rates. Such a unique tissue response at low doses of radiation exposure has been implicated in the context of the molecular basis of radiation-environment interplay in favor of recently emerging experimental evidence on DNA double-strand break repair pathway choice and its epigenetic memory by histone marking.

  18. Report on the results of the ninth medical examination of atomic bomb survivors in South America

    Energy Technology Data Exchange (ETDEWEB)

    Ohta, Michiya [Hiroshima Atomic Bomb Hospital (Japan); Hiyama, Keiko; Matsuo, Kakaru; Yamamoto, Hiroki; Nishida, Masashi; Sasaki, Yoshinobu

    2001-06-01

    The results of the ninth medical examination are reported. Atomic bomb survivors who had emigrated to South America as of November 2000 totaled 180 (153 to Brazil, 4 to Paraguay, 7 to Bolivia, 13 to Argentina, and 3 to Peru). Eighty persons (44.4%) were examined (62 in Brazil, 2 in Paraguay, 6 in Bolivia, 7 in Argentina, and 3 in Peru). The mean age of the males was 71.3 years, and the mean age of the females was 69.7 years. They had hypertension (24.1%), diabetes (10.1%), cancer (8.9%), heart disease (7.6%), and thyroid disease (2.5%). The most common manifestations of illness were fatigue (69.6%), loss of vigor (65.8%), taking medicine (55.7%), and heat intolerance (53.2%). The incident rates of electrocardiographic abnormalities and urine, blood, and biochemical tests abnormalities were almost the same as at the previous examination, and there was no change in the percentage of those who required detailed tests and treatment. When independence in daily life was judged by the criteria of the nursing care insurance system, 68 persons were judged ''independent'', and 7 persons ''handicapped.'' (K.H.)

  19. Cancer risk at low doses of ionizing radiation. Artificial neural networks inference from atomic bomb survivors

    International Nuclear Information System (INIS)

    Sasaki, Masao S.; Tachibana, Akira; Takeda, Shunichi

    2014-01-01

    Cancer risk at low doses of ionizing radiation remains poorly defined because of ambiguity in the quantitative link to doses below 0.2 Sv in atomic bomb survivors in Hiroshima and Nagasaki arising from limitations in the statistical power and information available on overall radiation dose. To deal with these difficulties, a novel nonparametric statistics based on the ‘integrate-and-fire’ algorithm of artificial neural networks was developed and tested in cancer databases established by the Radiation Effects Research Foundation. The analysis revealed unique features at low doses that could not be accounted for by nominal exposure dose, including (1) the presence of a threshold that varied with organ, gender and age at exposure, and (2) a small but significant bumping increase in cancer risk at low doses in Nagasaki that probably reflects internal exposure to 239 Pu. The threshold was distinct from the canonical definition of zero effect in that it was manifested as negative excess relative risk, or suppression of background cancer rates. Such a unique tissue response at low doses of radiation exposure has been implicated in the context of the molecular basis of radiation–environment interplay in favor of recently emerging experimental evidence on DNA double-strand break repair pathway choice and its epigenetic memory by histone marking. (author)

  20. Reassessment of the atomic bomb radiation dosimetry for Hiroshima and Nagasaki. Dosimetry system 2002. DS02. Volume 1

    International Nuclear Information System (INIS)

    Young, Robert W.; Kerr, George D.

    2005-01-01

    The extensive efforts to review the dosimetry of the atomic-bomb survivors and formulate the new dosimetry system DS02 have been greatly welcomed by the Radiation Effects Research Foundation (RERF). This accomplishment is a fine tribute to the importance of the epidemiological studies being conducted at RERF. No other study is so informative of the effects of radiation on human health. The gracious participation in the RERF program by the atomic-bomb survivors allows us to contribute to the well being of these individuals, and the high quality of the data obtained allows the RERF results to feature so prominently in the formulation of international guidelines for radiation protection. Such a great effort to improve and substantiate the dosimetry would not otherwise have been justified. RERF greatly appreciates the independent work of the U.S. and Japanese Working Groups on the atomic-bomb dosimetry and the review by the Joint Senior Review Group of this overall effort. We are assured that unbiased development of the new dosimetry system will reflect well in its application in the RERF epidemiology study. The documentation included in this report will serve as reference for the many deliberations concluded. The title publications are divided into 2 volumes. This is the first volume. The 8 of the reports in each chapter are indexed individually. (J.P.N.)

  1. Reassessment of the atomic bomb radiation dosimetry for Hiroshima and Nagasaki. Dosimetry system 2002. DS02. Volume 2

    International Nuclear Information System (INIS)

    Young, Robert W.; Kerr, George D.

    2005-01-01

    The extensive efforts to review the dosimetry of the atomic-bomb survivors and formulate the new dosimetry system DS02 have been greatly welcomed by the Radiation Effects Research Foundation (RERF). This accomplishment is a fine tribute to the importance of the epidemiological studies being conducted at RERF. No other study is so informative of the effects of radiation on human health. The gracious participation in the RERF program by the atomic-bomb survivors allows us to contribute to the well being of these individuals, and the high quality of the data obtained allows the RERF results to feature so prominently in the formulation of international guidelines for radiation protection. Such a great effort to improve and substantiate the dosimetry would not otherwise have been justified. RERF greatly appreciates the independent work of the U.S. and Japanese Working Groups on the atomic-bomb dosimetry and the review by the Joint Senior Review Group of this overall effort. We are assured that unbiased development of the new dosimetry system will reflect well in its application in the RERF epidemiology study. The documentation included in this report will serve as reference for the many deliberations concluded. The title publications are divided into 2 volumes. This is the second volume. The 29 of the reports in each chapter are indexed individually. (J.P.N.)

  2. A time series analysis on an individual data of atomic-bomb survivors and reduction to a medical treatment of atomic-bomb survivors using the results, 3

    International Nuclear Information System (INIS)

    Matsushita, Hiroshi; Hamada, Tadao; Kawagoe, Kazuko; Shigenobu, Takuzo; Matsuura, Chifumi.

    1980-01-01

    To prevent death of a-bomb survivors with myocardial infarction, a time series analysis of conditions of death caused by myocardial infarction was performed. Six a-bomb survivors who died of myocardial infarction were selected as subjects because their time series data could be obtained. Growth-equilibrium curves and polynomial trend line obtained from time series analysis were analysed by using a computer. Changes in a white blood cell count, a erythrocyte count, and Hb showed patterns of hemorrhagic shock at a terminal stage. Essential condition necessary for preservation of damaged heart was to keep up an erythrocyte count of 3,060,000 and Hb of 64.7%. The borderline between life and death was systolic pressure of 54 mmHg. It was demonstrated that prof. Abe's theory that the condition necessary for controlling diabetis is to keep up fasting glucose in blood of 140 mg/dl was correct. (Tsunoda, M.)

  3. Report on results of fourth medical examination of atomic bomb survivors residing in the U.S

    International Nuclear Information System (INIS)

    Monzen, Tetsuo; Ito, Chikako; Tanaka, Yoshikiyo; Kodama, Kazunori; Inamizu, Tsutomu.

    1984-01-01

    Review was made of the fourth medical examination and the actual state of health of the U.S. atomic-bomb (A-bomb) survivors. The number of survivors registered with the Committee of A-bomb Survivors residing in the U.S. as of the end of June 1983 in 592 (males 154, females 438), of whom 58.8% possess U.S. citizenship. Survivor's health handbooks issued to survivors under the Japanese A-bomb Survivors Medical Treatment Law are possessed by 29.2%, with female holders being about twice as numerous as males. Responses to the health survey questionnaire were received from 306. Complaints of subjective symptoms tended to be higher in the early entrants, and by place of examination, those of Honolulu had the higher rate. Those who underwent health examination numbered 305 (73 males and 232 females). RBC and hemoglobin value were higher in the U.S. survivors than in Hiroshima survivors. No abnormality was observed in 47.5%. The main abnormalities noted were obesity, hypertension, hyperlipidemia, ischemic heart disease, diabetes mellitus, hypothyroidism, and liver disease. Comparison of those who had received examination on two consecutive occasions in 1981 and 1983 and those who were examined for the first time in 1983 showed a decrease in the frequency of obesity and hypertension. (J.P.N.)

  4. Detection of de novo single nucleotide variants in offspring of atomic-bomb survivors close to the hypocenter by whole-genome sequencing.

    Science.gov (United States)

    Horai, Makiko; Mishima, Hiroyuki; Hayashida, Chisa; Kinoshita, Akira; Nakane, Yoshibumi; Matsuo, Tatsuki; Tsuruda, Kazuto; Yanagihara, Katsunori; Sato, Shinya; Imanishi, Daisuke; Imaizumi, Yoshitaka; Hata, Tomoko; Miyazaki, Yasushi; Yoshiura, Koh-Ichiro

    2018-03-01

    Ionizing radiation released by the atomic bombs at Hiroshima and Nagasaki, Japan, in 1945 caused many long-term illnesses, including increased risks of malignancies such as leukemia and solid tumours. Radiation has demonstrated genetic effects in animal models, leading to concerns over the potential hereditary effects of atomic bomb-related radiation. However, no direct analyses of whole DNA have yet been reported. We therefore investigated de novo variants in offspring of atomic-bomb survivors by whole-genome sequencing (WGS). We collected peripheral blood from three trios, each comprising a father (atomic-bomb survivor with acute radiation symptoms), a non-exposed mother, and their child, none of whom had any past history of haematological disorders. One trio of non-exposed individuals was included as a control. DNA was extracted and the numbers of de novo single nucleotide variants in the children were counted by WGS with sequencing confirmation. Gross structural variants were also analysed. Written informed consent was obtained from all participants prior to the study. There were 62, 81, and 42 de novo single nucleotide variants in the children of atomic-bomb survivors, compared with 48 in the control trio. There were no gross structural variants in any trio. These findings are in accord with previously published results that also showed no significant genetic effects of atomic-bomb radiation on second-generation survivors.

  5. Ionizing radiation exposure and the development of soft-tissue sarcomas in atomic-bomb survivors.

    Science.gov (United States)

    Samartzis, Dino; Nishi, Nobuo; Cologne, John; Funamoto, Sachiyo; Hayashi, Mikiko; Kodama, Kazunori; Miles, Edward F; Suyama, Akihiko; Soda, Midori; Kasagi, Fumiyoshi

    2013-02-06

    Very high levels of ionizing radiation exposure have been associated with the development of soft-tissue sarcoma. The effects of lower levels of ionizing radiation on sarcoma development are unknown. This study addressed the role of low to moderately high levels of ionizing radiation exposure in the development of soft-tissue sarcoma. Based on the Life Span Study cohort of Japanese atomic-bomb survivors, 80,180 individuals were prospectively assessed for the development of primary soft-tissue sarcoma. Colon dose in gray (Gy), the excess relative risk, and the excess absolute rate per Gy absorbed ionizing radiation dose were assessed. Subject demographic, age-specific, and survival parameters were evaluated. One hundred and four soft-tissue sarcomas were identified (mean colon dose = 0.18 Gy), associated with a 39% five-year survival rate. Mean ages at the time of the bombings and sarcoma diagnosis were 26.8 and 63.6 years, respectively. A linear dose-response model with an excess relative risk of 1.01 per Gy (95% confidence interval [CI]: 0.13 to 2.46; p = 0.019) and an excess absolute risk per Gy of 4.3 per 100,000 persons per year (95% CI: 1.1 to 8.9; p = 0.001) were noted in the development of soft-tissue sarcoma. This is one of the largest and longest studies (fifty-six years from the time of exposure to the time of follow-up) to assess ionizing radiation effects on the development of soft-tissue sarcoma. This is the first study to suggest that lower levels of ionizing radiation may be associated with the development of soft-tissue sarcoma, with exposure of 1 Gy doubling the risk of soft-tissue sarcoma development (linear dose-response). The five-year survival rate of patients with soft-tissue sarcoma in this population was much lower than that reported elsewhere.

  6. Psychological problems of atomic bomb survivors from the medical social worker's standpoint

    International Nuclear Information System (INIS)

    Tomoike, Toshio

    1994-01-01

    Mental data from 80 A-bomb survivors were available during a 20-year period 1973-1992. Types of A-bomb survivors were classified into (1) directly exposed A-bomb survivors, (2) A-bomb survivors living in the United States, (3) those living in prefectures other than Nagasaki, (4) ex-soldiers, (5) A-bomb survivors having family problems and others, (6) the demented elderly, (7) the alcoholic, and (8) others. Mental problems were judged as psychogenic, endogenous, and exogenous. Mental problems were most frequently associated with Type 1 (34.9%), followed by Type 8 (21.0%), Type 2 (18.6%), and Type 3 (7.0%). Noticeable finding was that Type 1 A-bomb survivors suffered from psychogenic and exogenous mental problems in an extremely high incidence, as compared with the non-exposed group (66.3% vs 24%). The incidence of both exogenous and endogenous problems was higher in the non-exposed group (32.6% and 24.5%) than the exposed group (23.2% and 10.5%). There was no significant gender difference in the development of mental problems. According to types of A-bomb survivors, both psychogenic and exogenous mental problems were most common for Type 1. The incidence of psychogenic problems was 2.85 times higher than that of exogenous problems. (N.K.)

  7. Prevalence rate of thyroid diseases among autopsy cases of the atomic bomb survivors in Hiroshima, 1951-1985

    International Nuclear Information System (INIS)

    Yoshimoto, Yasuhiko; Ezaki, Haruo; Etoh, Ryozo; Hiraoka, Toshio; Akiba, Suminori

    1995-01-01

    To examine the radiogenic risk of latent thyroid cancer, thyroid adenoma, colloid/adenomatous goiter and chronic thyroiditis, the date for 3821 subjects collected in the course of autopsies of atomic bomb survivors in Hiroshima from 1951 to 1985 by the Radiation Effects Research Foundation (RERF) were analyzed using a logistic model. About 80% of the autopsies were performed at RERF and the remainder at local hospitals. The frequencies of the above diseases were not associated with whether the underlying cause of death was cancer. However, note that our results may be influenced by potentially biasing factors associated with autopsy selection. The relative frequency of latent thyroid cancer (greatest dimension ≤1.5 cm but detectable on a routine microscopic slide of the thyroid gland) increased as the radiation dose increased and was about 1.4-fold greater at 1 Gy than in the 0-Gy dose group. The relative occurrence of thyroid adenoma also increased as radiation dose increased, and was about 1.5-fold greater at 1 Gy than in the 0-Gy dose group. Sex, age at the time of the bombing or period of observation did not significantly modify the radiogenic risks for thyroid adenoma or latent thyroid cancer. No statistically significant association was found between radiation exposure and the rates of colloid/adenomatous goiter and chronic thyroiditis. The possible late effect of atomic bomb radiation on the frequency of benign thyroid diseases is discussed on the basis of these data. 38 refs., 2 figs., 5 tabs

  8. Workshop Report on Atomic Bomb Dosimetry--Review of Dose Related Factors for the Evaluation of Exposures to Residual Radiation at Hiroshima and Nagasaki.

    Science.gov (United States)

    Kerr, George D; Egbert, Stephen D; Al-Nabulsi, Isaf; Bailiff, Ian K; Beck, Harold L; Belukha, Irina G; Cockayne, John E; Cullings, Harry M; Eckerman, Keith F; Granovskaya, Evgeniya; Grant, Eric J; Hoshi, Masaharu; Kaul, Dean C; Kryuchkov, Victor; Mannis, Daniel; Ohtaki, Megu; Otani, Keiko; Shinkarev, Sergey; Simon, Steven L; Spriggs, Gregory D; Stepanenko, Valeriy F; Stricklin, Daniela; Weiss, Joseph F; Weitz, Ronald L; Woda, Clemens; Worthington, Patricia R; Yamamoto, Keiko; Young, Robert W

    2015-12-01

    Groups of Japanese and American scientists, supported by international collaborators, have worked for many years to ensure the accuracy of the radiation dosimetry used in studies of health effects in the Japanese atomic bomb survivors. Reliable dosimetric models and systems are especially critical to epidemiologic studies of this population because of their importance in the development of worldwide radiation protection standards. While dosimetry systems, such as Dosimetry System 1986 (DS86) and Dosimetry System 2002 (DS02), have improved, the research groups that developed them were unable to propose or confirm an additional contribution by residual radiation to the survivor's total body dose. In recognition of the need for an up-to-date review of residual radiation exposures in Hiroshima and Nagasaki, a half-day technical session was held for reports on newer studies at the 59 th Annual HPS Meeting in 2014 in Baltimore, MD. A day-and-a-half workshop was also held to provide time for detailed discussion of the newer studies and to evaluate their potential use in clarifying the residual radiation exposure to atomic bomb survivors at Hiroshima and Nagasaki. The process also involved a re-examination of very early surveys of radioisotope emissions from ground surfaces at Hiroshima and Nagasaki and early reports of health effects. New insights were reported on the potential contribution to residual radiation from neutron-activated radionuclides in the airburst's dust stem and pedestal and in unlofted soil, as well as from fission products and weapon debris from the nuclear cloud. However, disparate views remain concerning the actual residual radiation doses received by the atomic bomb survivors at different distances from the hypocenter. The workshop discussion indicated that measurements made using thermal luminescence and optically stimulated luminescence, like earlier measurements, especially in very thin layers of the samples, could be expanded to detect possible

  9. Reanalysis of atomic bomb survivors' leukemia based on the recent classification for leukemias

    International Nuclear Information System (INIS)

    Matsuo, Tatsuki; Tomonaga, Masao.

    1990-01-01

    Four hundred and ninety-three A-bomb survivors developing leukemia, who had been exposed within 9,000 m from the hypocenter, were entered on the study for reanalysis of their disease based on the new classification. Chronic myelocytic leukemia (CML) showed the highest concordance rate (95%) between the previous and new classifications. For 10 survivors previously diagnosed as having chronic lymphocytic leukemia (CLL), a new classification diagnosed CLL as well in 3 and adult T-cell leukemia in the other 7. None of the A-bomb survivors exposed to one Gy or more had subtype M3 of acute myelocytic leukemia (AML), although the exposed group had almost the same distribution pattern of AML subtypes as the naturally induced leukemic group. The incidence of CML was significantly lower than that of AML in Nagasaki A-bomb survivors. As A-bomb survivors were older at the time of A-bombing, the relative risk of acute lymphoblastic leukemia (ALL) was decreased; that of CML and other types of leukemia was increased. An increased relative risk of ALL and CML tended to be associated with larger doses. A significantly shortened interval between A-bomb exposure and the development of leukemia was also associated with larger doses. (N.K.)

  10. Was Nazi Germany on the Road to an Atomic Bomb after all?

    Science.gov (United States)

    Lustig, Harry

    2006-04-01

    The story of Germany's efforts to develop a nuclear weapon during World War II is a much written about and contentious subject. However there has been agreement on one thing: by the end of the War the Germans had not achieved and were nowhere near to building a bomb. The dispute therefore has been about why Germany did not succeed. Now, from Germany, comes a challenge to this truth, in the provocative book Hitlers Bombe by Rainer Karlsch. The bombshell in Hitler's Bombe is the assertion that German scientists developed and tested a primitive fission and fusion nuclear weapon in March 1945. Karlsch bases this claim on testimony of witnesses in 1962, previously secret Russian documents, and the results of soil tests carried out in 2004 and 2005. However the physics is very murky and it seems out of the question that Germany had enough Uranium 235 or produced any Plutonium for a bomb. Hitlers Bombe also makes other, better documented and more credible revisionist assertions. These include the claim that the Nazis did continue to try to build a bomb after 1942 and that not Werner Heisenberg, but Kurt Diebner and Walther Gerlach were then the leaders of the German Uranium project. Karlsch's book therefore deserves more attention from physicists and historians than it has received in the United States.

  11. Joint analysis of site-specific cancer risks for the atomic bomb survivors

    International Nuclear Information System (INIS)

    Pierce, D.A.; Preston, D.L.

    1993-01-01

    Statistical methods are presented for joint analysis of site-specific cancer risks for the atomic-bomb survivors. Previous analyses of these data, aside from those on leukemia, have been made either without regard to cancer type, or separately for types or classes of cancers. Clearly, analyses without regard to cancer type are less than satisfactory. The primary advantages of joint, rather than separate, analyses are that (1) models can be fitted with parameters common to cancer types, which can allow more-precise estimation of effects of interest, (2) significance tests can be used to compare type-specific risks, and (3) a clearer understanding may be obtained of risk-modification factors such as sex, age at exposure, and time since exposure. Joint analysis is straightforward, entailing primarily the incorporation of another factor for cancer type in the usual cross-tabulation of the data for analysis. The use of these methods is illustrated in an analysis of the three categories of cancer studied by the fifth Advisory Committee on the Biological Effects of Ionizing Radiation (BEIR V): digestive, respiratory, and other solid tumors. Based on this analysis, some criticism is made of the BEIR V-preferred models. Since the proposed methods are applicable to models for either relative or absolute risks, some comments on the use of explicit models for the absolute excess risk are also given. Although some of the gains from joint analysis are apparent from the results here, it will be important to use these methods with a more suitable choice of cancer classes and for cancer incidence data in which the diagnoses are more accurate. (author)

  12. Agreement between death-certificate and autopsy diagnoses among atomic-bomb survivors

    International Nuclear Information System (INIS)

    Ron, E.; Carter, R.L.; Jablon, S.; Mabuchi, Kiyohiko.

    1993-11-01

    Using the Atomic Bomb Casualty Commission/Radiation Effects Research Foundation series of over 5000 autopsies, we examined death-certificate accuracy for several disease categories and assessed the effect of potential modifying factors on this accuracy. For 12 cause-of-death categories, the overall percent agreement between death-certificate and autopsy diagnoses was only 52.5%. Although neoplasms had the highest detection rate (on the death certificate) in the study, still almost 25% of cancers diagnosed at autopsy were missed on the death certificate. Only for neoplasms and external causes of death were confirmation and detection rates above 70%. Confirmation rates were between 50% and 70% for infectious and parasitic diseases and heart and other vascular diseases. Detection rates reached a similar level for infectious and parasitic, cerebrovascular, and digestive diseases. Specificity rates were above 90% for all but the cerebrovascular disease category. Overall agreement decreased with increasing age of the decedents and was lower for deaths occurring outside of hospital vs those occurring in a hospital. There was some suggestion that agreement rates were higher for more-recent deaths but no indication that radiation dose, sex, city of residence, or inclusion in a biennial clinical-examination program influenced agreement. Because the inaccuracy of death-certificate diagnoses can have major implications for many aspects of health research and planning, it is important to be aware that death-certificate accuracy is low and can vary widely depending on the patient's age at death and the place of death. (J.P.N.)

  13. Papillary microcarcinoma of the thyroid among atomic bomb survivors: tumor characteristics and radiation risk.

    Science.gov (United States)

    Hayashi, Yuzo; Lagarde, Frederic; Tsuda, Nobuo; Funamoto, Sachiyo; Preston, Dale L; Koyama, Kojiro; Mabuchi, Kiyohiko; Ron, Elaine; Kodama, Kazunori; Tokuoka, Shoji

    2010-04-01

    : Radiation exposure is an established cause of clinical thyroid cancer, but little is known about radiation effects on papillary microcarcinoma (PMC) of the thyroid, a relatively common subclinical thyroid malignancy. Because the incidence of these small thyroid cancers has been increasing, it is important to better understand them and their relation to radiation. : PMCs were identified in a subset of 7659 members of the Life Span Study of atomic bomb survivors who had archived autopsy or surgical materials. We conducted a pathology review of these specimens and evaluated the histological features of the tumors and the association between PMCs and thyroid radiation dose. : From 1958 to 1995, 458 PMCs were detected among 313 study subjects. The majority of cancers exhibited pathologic features of papillary thyroid cancers. Overall, 81% of the PMCs were of the sclerosing variant and 91% were nonencapsulated, psammoma bodies that occurred in 13% and calcification was observed in 23%. Over 95% had papillary or papillary-follicular architecture and most displayed nuclear overlap, clear nuclei, and nuclear grooves. Several of these features increased with increasing tumor size, but no association was found with radiation dose. A significant radiation-dose response was found for the prevalence of PMCs (estimated excess odds ratio/Gy = 0.57; 95% confidence interval, 0.01-1.55), with the excess risk observed primarily among women. : Exposure to low-to-moderate doses of ionizing radiation appears to increase the risk of thyroid PMCs, even when exposure occurs during adulthood. Cancer 2010. (c) 2010 American Cancer Society.

  14. Cancer incidence in atomic bomb survivors. Part IV: Comparison of cancer incidence and mortality

    International Nuclear Information System (INIS)

    Ron, E.; Preston, D.L.; Mabuchi, Kiyohiko; Thompson, D.E.; Soda, Midori

    1994-01-01

    This report compares cancer incidence and mortality among atomic bomb survivors in the Radiation Effects Research Foundation Life Span Study (LSS) cohort. Because the incidence data are derived from the Hiroshima and Nagasaki tumor registries, case ascertainment is limited to the time (1958-1987) and geographic restrictions (Hiroshima and Nagasaki) of the registries, whereas mortality data are available from 1950-1987 anywhere in Japan. With these conditions, there were 9,014 first primary incident cancer cases identified among LSS cohort members compared with 7,308 deaths for which cancer was listed as the underlying cause of death on death certificates. When deaths were limited to those occurring between 1958-1987 in Hiroshima or Nagasaki, there were 3,155 more incident cancer cases overall, and 1,262 more cancers of the digestive system. For cancers of the oral cavity and pharynx, skin, breast, female and male genital organs, urinary system and thyroid, the incidence series was at least twice as large as the comparable mortality series. Although the incidence and mortality data are dissimilar in many ways, the overall conclusions regarding which solid cancers provide evidence of a significant dose response generally confirm the mortality findings. When either incidence or mortality data are evaluated, significant excess risks are observed for all solid cancers, stomach, colon, liver (when it is defined as primary liver cancer or liver cancer not otherwise specified on the death certificate), lung, breast, ovary and urinary bladder. No significant radiation effect is seen for cancers of the pharynx, rectum, gallbladder, pancreas, nose, larynx, uterus, prostate or kidney in either series. There is evidence of a significant excess of nonmelanoma skin cancer in the incidence data, but not in the mortality series. 19 refs., 2 figs., 10 tabs

  15. Cytogenetic study of the offspring of atomic bomb survivors, Hiroshima and Nagasaki

    International Nuclear Information System (INIS)

    Awa, A.A.; Honda, Takeo; Neriishi, Shotaro

    1989-07-01

    This paper describes the results of a cytogenetic study on 8,322 children born to atomic bomb survivors (4,716 in Hiroshima and 3,606 in Nagasaki) and 7,976 controls (5,112 in Hiroshima and 2,864 in Nagasaki). Because no child was examined before age 12, the data may not be considered valid for the occurrence of chromosomal abnormalities that impose a high risk of early death. Thus, we will restrict our comparison to the sex-chromosome aneuploids and autosomal structural rearrangements of the balanced type, although other abnormalities encountered in this survey will be enumerated. Among the children born to exposed parents, 19 individuals (0.23 %) exhibited sex chromosome abnormalities and 23 (0.28 %) exhibited autosomal structural rearrangements, whereas among children born to unexposed parents, 24 (0.30 %) and 27 (0.34 %), respectively, were observed to exhibit these abnormalities. Only one child with a karyotype of 47,XY,+21 was found in the Hiroshima exposed group. Thus, there was no statistically significant difference in the overall frequencies of cytogenetically abnormal cases between the exposed (0.52 %) and control (0.64 %) populations. In Hiroshima, frequencies of chromosome abnormalities were similar between exposed and control groups (0.64 % vs 0.65 %). However, the value observed in the exposed group in Nagasaki was slightly lower (0.36 %) - though not statistically significant - than the value observed in the control group (0.63 %). This value of the Nagasaki control group was similar to that in Hiroshima. Family studies on probands with chromosome abnormalities revealed that the majority of cases (about 90 %) with autosomal structural rearrangements of the balanced type were inherited from one or the other parent. The mutation rates for these reaarangements were similar between the exposed and control groups, being 0.98 x 10 -4 per gamete per generation. (author)

  16. Incidence of leukemia in atomic bomb survivors belonging to a fixed cohort in Hiroshima and Nagasaki, 1950-71

    International Nuclear Information System (INIS)

    Ichimaru, Michito; Ishimaru, Toranosuke; Belsky, J.L.

    1978-01-01

    The leukemogenic effect of atomic radiation was examined in relation to age at the time of the bomb (ATB), calendar time, and type of leukemia over the period 1950-71. Confirmed cases of leukemia in the Leukemia Registry, a fixed cohort of 109,000 subjects and the T65 dose calculations provided the basis for the analysis. Calendar time was divided into three periods, 5-10, 10-15, and 15-26 years after the bombs. The larger the exposure dose and the younger the age ATB, the greater was the effect in the early period and the more rapid was the decline in risk in subsequent years. In the oldest group, aged 45 or over ATB, the increase in risk appeared later and was sustained in the period 1960-71. Chronic granulocytic leukemia contributed substantially to the total leukemogenic effect initially but made little contribution after 1955. Sensitivity to the leukemogenic effect of atomic radiation not only depended on age ATB but its expression varied by type of leukemia and with time after exposure. Although the effect of atomic radiation on the incidence of leukemia in the atomic survivors is now greatly reduced and apparently on the wane, in the period 1966-71 the incidence was still greater than expected, especially in Hiroshima. In the Nagasaki sample, no case of leukemia was observed among the high-dose subjects from July 1966 to the end of 1971. (author)

  17. Solid Cancer Incidence among the Life Span Study of Atomic Bomb Survivors: 1958-2009.

    Science.gov (United States)

    Grant, Eric J; Brenner, Alina; Sugiyama, Hiromi; Sakata, Ritsu; Sadakane, Atsuko; Utada, Mai; Cahoon, Elizabeth K; Milder, Caitlin M; Soda, Midori; Cullings, Harry M; Preston, Dale L; Mabuchi, Kiyohiko; Ozasa, Kotaro

    2017-05-01

    This is the third analysis of solid cancer incidence among the Life Span Study (LSS) cohort of atomic bomb survivors in Hiroshima and Nagasaki, adding eleven years of follow-up data since the previously reported analysis. For this analysis, several changes and improvements were implemented, including updated dose estimates (DS02R1) and adjustment for smoking. Here, we focus on all solid cancers in aggregate. The eligible cohort included 105,444 subjects who were alive and had no known history of cancer at the start of follow-up. A total of 80,205 subjects had individual dose estimates and 25,239 were not in either city at the time of the bombings. The follow-up period was 1958-2009, providing 3,079,484 person-years of follow-up. Cases were identified by linkage with population-based Hiroshima and Nagasaki Cancer Registries. Poisson regression methods were used to elucidate the nature of the radiation-associated risks per Gy of weighted absorbed colon dose using both excess relative risk (ERR) and excess absolute risk (EAR) models adjusted for smoking. Risk estimates were reported for a person exposed at age 30 years with attained age of 70 years. In this study, 22,538 incident first primary solid cancer cases were identified, of which 992 were associated with radiation exposure. There were 5,918 cases (26%) that occurred in the 11 years (1999-2009) since the previously reported study. For females, the dose response was consistent with linearity with an estimated ERR of 0.64 per Gy (95% CI: 0.52 to 0.77). For males, significant upward curvature over the full dose range as well as restricted dose ranges was observed and therefore, a linear-quadratic model was used, which resulted in an ERR of 0.20 (95% CI: 0.12 to 0.28) at 1 Gy and an ERR of 0.010 (95% CI: -0.0003 to 0.021) at 0.1 Gy. The shape of the ERR dose response was significantly different among males and females (P = 0.02). While there was a significant decrease in the ERR with increasing attained age, this

  18. Report on the results of the fourteenth medical examination of atomic bomb survivors resident in North America

    International Nuclear Information System (INIS)

    Yanagida, Jitsuro; Kambe, Masayuki; Hakoda, Masayuki

    2004-01-01

    The fourteenth medical examination of atomic-bomb (A-bomb) survivors resident in North America was carried out from June 18th through July 2nd and from July 24th through August 6th, 2003, in the cities of Los Angeles, San Francisco, Seattle, and Honolulu. The total number of those who underwent the fourteenth medical examination was 453, 65 of whom were second-generation A-bomb survivors. As the survivors in North America are advancing in age, the average age of the examinee was 71.6 years. The examination items included an interview, clinical and physical examinations, electrocardiography (E.C.G.), and blood, urine, and stool tests. The review of the medical history showed that hypertension was the most frequent in the survivors examined, with the prevalence of 45.4%. Previous history of malignant tumors was observed in 15.7% of the survivors examined, with major sites being the mammary gland, uterine, colon, and prostate. As a result of the blood test, 14.9% of the survivors examined were diagnosed as diabetic, and hypercholesterolemia was found in 28.4% of the survivors examined. Latent hypothyroidism was found in 21.2% of the survivors examined. No disease or examination finding showed a clear relation with exposure status. A report providing the results of the medical examination and necessity of undergoing closer examination and receiving medical treatment, if any, was mailed to each examinee. (author)

  19. CD14 and IL18 gene polymorphisms associated with colorectal cancer subsite risks among atomic bomb survivors.

    Science.gov (United States)

    Hu, Yiqun; Yoshida, Kengo; Cologne, John B; Maki, Mayumi; Morishita, Yukari; Sasaki, Keiko; Hayashi, Ikue; Ohishi, Waka; Hida, Ayumi; Kyoizumi, Seishi; Kusunoki, Yoichiro; Tokunaga, Katsushi; Nakachi, Kei; Hayashi, Tomonori

    2015-01-01

    Colorectal cancer (CRC) is a common malignancy worldwide, and chronic inflammation is a risk factor for CRC. In this study, we carried out a cohort study among the Japanese atomic bomb (A-bomb) survivor population to investigate any association between immune- and inflammation-related gene polymorphisms and CRC. We examined the effects of six single-nucleotide polymorphisms of CD14 and IL18 on relative risks (RRs) of CRC. Results showed that RRs of CRC, overall and by anatomic subsite, significantly increased with increasing radiation dose. The CD14-911A/A genotype showed statistically significant higher risks for all CRC and distal CRC compared with the other two genotypes. In addition, the IL18-137 G/G genotype showed statistically significant higher risks for proximal colon cancer compared with the other two genotypes. In phenotype-genotype analyses, the CD14-911A/A genotype presented significantly higher levels of membrane and soluble CD14 compared with the other two genotypes, and the IL18-137 G/G genotype tended to be lower levels of plasma interleukin (IL)-18 compared with the other two genotypes. These results suggest the potential involvement of a CD14-mediated inflammatory response in the development of distal CRC and an IL18-mediated inflammatory response in the development of proximal colon cancer among A-bomb survivors.

  20. RET/PTC rearrangements preferentially occurred in papillary thyroid cancer among atomic bomb survivors exposed to high radiation dose.

    Science.gov (United States)

    Hamatani, Kiyohiro; Eguchi, Hidetaka; Ito, Reiko; Mukai, Mayumi; Takahashi, Keiko; Taga, Masataka; Imai, Kazue; Cologne, John; Soda, Midori; Arihiro, Koji; Fujihara, Megumu; Abe, Kuniko; Hayashi, Tomayoshi; Nakashima, Masahiro; Sekine, Ichiro; Yasui, Wataru; Hayashi, Yuzo; Nakachi, Kei

    2008-09-01

    A major early event in papillary thyroid carcinogenesis is constitutive activation of the mitogen-activated protein kinase signaling pathway caused by alterations of a single gene, typically rearrangements of the RET and NTRK1 genes or point mutations in the BRAF and RAS genes. In childhood papillary thyroid cancer, regardless of history of radiation exposure, RET/PTC rearrangements are a major event. Conversely, in adult-onset papillary thyroid cancer among the general population, the most common molecular event is BRAF(V600E) point mutation, not RET/PTC rearrangements. To clarify which gene alteration, chromosome aberration, or point mutation preferentially occurs in radiation-associated adult-onset papillary thyroid cancer, we have performed molecular analyses on RET/PTC rearrangements and BRAF(V600E) mutation in 71 papillary thyroid cancer cases among atomic bomb survivors (including 21 cases not exposed to atomic bomb radiation), in relation to radiation dose as well as time elapsed since atomic bomb radiation exposure. RET/PTC rearrangements showed significantly increased frequency with increased radiation dose (P(trend) = 0.002). In contrast, BRAF(V600E) mutation was less frequent in cases exposed to higher radiation dose (P(trend) < 0.001). Papillary thyroid cancer subjects harboring RET/PTC rearrangements developed this cancer earlier than did cases with BRAF(V600E) mutation (P = 0.03). These findings were confirmed by multivariate logistic regression analysis. These results suggest that RET/PTC rearrangements play an important role in radiation-associated thyroid carcinogenesis.

  1. Cytogenetic studies on leukemia and preleukemic state in atomic bomb survivors

    International Nuclear Information System (INIS)

    Sadamori, Naoki; Tomonaga, Yu; Tagawa, Masuko; Kusano, Miyuki; Nishino, Kenji

    1980-01-01

    Chromosomal abberation of bone marrow cells in healthy persons and patients with various hematologic diseases both of the exposed and the non-exposed were discussed. One healthy a-bomb survivor exposed near the hypocenter and structural abnormality of chromosomes closely similar to that found out in a small number of patients with hematologic diseases, but clone formation was not recognized. Though it was clarified that there was chromosomal abberation peculiar to each hematologic disease, specific chromosomal abberation peculiar to a-bomb survivors with hematologic diseases was not recognized. There were many a-bomb survivors with hemopoietic dysplasia who had structural abnormality of chromosomes, and their frequency was significantly higher than that of the non-exposed. (Tsunoda, M.)

  2. A search for genetic effects of atomic bomb radiation on the growth and development of the F1 generation, 1

    International Nuclear Information System (INIS)

    Furusho, Toshiyuki; Otake, Masanori.

    1978-10-01

    In a search for possible genetic effects of atomic bomb radiation on the growth and development of offspring of A-bomb survivors a survey was made in 1965 on approximately 200,000 children of all primary schools, junior high schools, and senior high schools in the cities of Hiroshima and Nagasaki. Of the collected data, those pertaining to senior high school students 15 to 17 years of age of Hiroshima City were analyzed to determine if there was any genetic effect of A-bomb radiation on stature. Comparisons were made with regard to the mean stature and variance of the offspring and the covariance and correlation between one parent or the sum for both parents and offspring for the exposed group and the nonexposed group. The observed differences included those with both positive and negative signs, but none were statistically significant nor did they demonstrate any specific tendency. A comparison was made with a similar study reported by Neel and Schull. Furthermore, estimation of the regression coefficients of the mean stature, variance, covariance, and correlation between one parent or the sum for both parents and offspring by parental radiation dose also did not show any specific tendency. Though the genetic effects of A-bomb radiation on stature could not be accurately estimated in the current series of analyses, the stature data of 6- to 14-year-old children in Hiroshima and those of 6- to 17-year-old children in Nagasaki Will soon be studied, which should permit a more comprehensive and extensive analysis and evaluation of the possible genetic effects of radiation on stature. (author)

  3. Delayed effects occurring within the first decade after exposure of young individuals to the Hiroshima atomic bomb

    Energy Technology Data Exchange (ETDEWEB)

    Miller, R.W.

    1956-01-01

    The review of the literature and the data presented in this report describe the late effects of exposure of young subjects to ionizing radiation or to nuclear weapons as known in the early part of 1955. The new information may be useful in the further definition of the tolerance of humans to ionizing radiation. In 6 years ending in December 1954, 19 persons who were within 2100 meters of the hypocenter have developed leukemia before attaining the age of 19 years. The annual incidence of this disease among those who were within 1500 meters and who were younger than 19 years of age at the time of exposure is 1:1000. There are no cataracts that impair vision among the present pediatic group. An increased incidence of a mild visual disability, the cause of which is thus far indefinite, has been found among those now 16 through 19 years of age who were within 1800 meters of the bomb center. The incidence of chronic otitis media is the same for the 2 exposure groups, as are the means of the hematologic values for the patients with this ailment. There is no increase in the tumor incidence of the exposed children as compared with the nonexposed. There are no data to prove it, but the impression is that among the survivors the fear of late effects may be common and potentially disabling. Of those 19 years of age and younger, there were 2771 within 3000 meters of the hypocenter at the time of detonation of the bomb who were examined in 1954. Twenty-four of these had sequelae of the blast or thermal effects of the bomb other than well-heated scars. No other abnormalities related to atomic bomb exposure have been identified.

  4. Risk of death among children of atomic bomb survivors after 62 years of follow-up: a cohort study.

    Science.gov (United States)

    Grant, Eric J; Furukawa, Kyoji; Sakata, Ritsu; Sugiyama, Hiromi; Sadakane, Atsuko; Takahashi, Ikuno; Utada, Mai; Shimizu, Yukiko; Ozasa, Kotaro

    2015-10-01

    No clear epidemiological hereditary effects of radiation exposure in human beings have been reported. However, no previous studies have investigated mortality into middle age in a population whose parents were exposed to substantial amounts of radiation before conception. We assessed mortality in children of the atomic bomb survivors after 62 years of follow-up. In this prospective cohort study, we assessed 75 327 singleton children of atomic bomb survivors in Hiroshima and Nagasaki and unexposed controls, born between 1946 and 1984, and followed up to Dec 31, 2009. Parental gonadal doses of radiation from the atomic bombings were the primary exposures. The primary endpoint was death due to cancer or non-cancer disease, based on death certificates. Median follow-up was 54·3 years (IQR 45·4-59·3). 5183 participants died from disease. The mean age of the 68 689 surviving children at the end of follow-up was 53·1 years (SD 7·9) with 15 623 (23%) older than age 60 years. For parents who were exposed to a non-zero gonadal dose of radiation, the mean dose was 264 mGy (SD 463). We detected no association between maternal gonadal radiation exposure and risk of death caused by cancer (hazard ratio [HR] for 1 Gy change in exposure 0·891 [95% CI 0·693-1·145]; p=0·36) or risk of death caused by non-cancer diseases (0·973 [0·849-1·115]; p=0·69). Likewise, paternal exposure had no effect on deaths caused by cancer (0·815 [0·614-1·083]; p=0·14) or deaths caused by non-cancer disease (1·103 [0·979-1·241]; p=0·12). Age or time between parental exposure and delivery had no effect on risk of death. Late effects of ionising radiation exposure include increased mortality risks, and models of the transgenerational effects of radiation exposure predict more genetic disease in the children of people exposed to radiation. However, children of people exposed to the atomic bombs in Hiroshima and Nagasaki had no indications of deleterious health effects after 62

  5. Synthetic medical studies on atomic bomb survivors exposed in short distances, 13

    International Nuclear Information System (INIS)

    Kamada, Nanao; Tanaka, Kimio; Kuramoto, Atsushi; Yamamoto, Hisashi; Munaka, Masaki; Hattori, Takao; Yokoro, Kenjiro; Kurihara, Minoru

    1986-01-01

    An analysis for chromosome breakpoints in 731 cells with chromosome aberrations obtained from 39 A-bomb survivors was made. There were 50 chromosome regions where the number of breaks was significantly higher than the expected number (p < 0.05). Twenty of these regions were common to those specific to cancer cells, and 16 were common to fragile sites. Chromosome regions commonly seen for constitutional fragile sites, chromosome aberrations in A-bomb survivors and cancer patients were 5q31, 6q25, 8q24, 11q23, and 17q23. (Namekawa, K.)

  6. Cancer incidence in atomic bomb survivors. Part III: Leukemia, lymphoma and multiple myeloma, 1950-1987

    International Nuclear Information System (INIS)

    Preston, D.L.; Izumi, Shizue; Kusumi, Shizuyo; Tomonaga, Masao; Ron, E.; Kuramoto, Atsushi; Kamada, Nanao; Dohy, Hiroo; Matsui, Tatsuki; Nonaka, Hiroaki

    1994-01-01

    This paper presents an analysis of data on the incidence of leukemia, lymphoma and myeloma in the Life Span Study cohort of atomic bomb survivors during the period from late 1950 through the end of 1987 (93,696 survivors accounting for 2,778,000 person-years). These analyses add 9 additional years of follow-up for leukemia and 12 for myeloma to that in the last comprehensive reports on these diseases. This is the first analysis of the lymphoma incidence data in the cohort. Using both the Leukemia Registry and the Hiroshima and Nagasaki tumor registries, a total of 290 leukemia, 229 lymphoma and 73 myeloma cases were identified. The primary analyses were restricted to first primary tumors diagnosed among residents of the cities or surrounding areas with Dosimetry Systems 1986 dose estimates between 0 and 4 Gy kerma (231 leukemias, 208 lymphomas and 62 myelomas). Analyses focused on time-dependent models for the excess absolute risk. Separate analyses were carried out for acute lymphocytic leukemia (ALL), acute myelogenous leukemia (AML), chronic myelocytic leukemia (CML) and adult T-cell leukemia in this population. There was strong evidence of radiation-induced risks for all subtypes except ATL, and there were significant subtype differences with respect to the effects of age at exposure and sex and in the temporal pattern of risk. The AML dose-response function was nonlinear, whereas there was no evidence against linearity for the other subtypes. When averaged over the follow-up period, the excess absolute risk (EAR) estimates (in cases per 10 4 PY Sv) for the leukemia subtypes were 0.6, 1.1 and 0.9 for ALL, AML and CML, respectively. The corresponding estimated average excess relative risks at 1 Sv are 9.1, 3.3 and 6.2, respectively. There was some evidence of an increased risk of lymphoma in males (EAR = 0.6 cases per 10 4 PY Sv) but no evidence of any excess in females. 64 refs., 14 figs., 19 tabs

  7. Mental disorders in 37 cases of 'Hibakusya' 40 years after exposure to the atomic bomb

    International Nuclear Information System (INIS)

    Nonaka, Takeshi; Tohyama, Teruhiko; Nakazawa, Masao; Ando, Ichiro; Hayashi, Hideki; Miura, Hirofumi

    1987-01-01

    In 1985, 40 years after the bombing, 37 (8 %) of a total of 814 A-bomb survivors living in Tokyo visited the Department of Neuro-Psychiatry. This is an analysis of these A-bomb survivors suffering from mental disorders. There were 11 men and 26 women. They ranged in age from 45 to 87 years with a median of 61. Eighteen survivors (55 %) were exposed within 2,000 m from ground zero, and 21 (66 %) presented with acute radiation symptoms. According to the classification of DSM-III, features of mental disorders fell into five types: (1) organic psychotic conditions (n = 7), (2) endogenous psychotic conditions (n = 14), (3) delution (n = 3), (4) anxiety somatization (n = 11), and (5) personality disorder (n = 2). Psychotic conditions characterized by mixed atypical symptoms, variable clinical features during the process, and undefined somatic symptoms were noticeable in this series. This is in contrast to the previous reports dealing with neurasthenic A-bomb survivors. The etiology of psychotic conditions must await further study. (Namekawa, K.)

  8. Relationship between epidemiological factors and mortality among atomic bomb survivors, Hiroshima and Nagasaki

    International Nuclear Information System (INIS)

    Nagai, Masanori

    1980-01-01

    In 1965, mail survey on environmental and individual factors was performed for 11,724 male a-bomb survivors, with the age of 40 to 69, selected from the group subjected to joint JNIH-ABCC investigation of life span in a-bomb survivors. During 10 years after the mail survey, 2,834 died. The aim of this mail survey was to clarify the relationship between the mortality and specific environmental, social, and economic factors. There was a relationship between high mortality and low social and economical condition for all causes of death combined, cerebral vascular diseases, all malignant neoplasms, and gastric cancer. Smoking was a significant risk factor to all causes of death combined, ischemic heart diseases, all malignant neoplasms, gastric, tracheal, bronchial, and lung cancers. The mortality due to cardiovascular diseases was significantly higher in a-bomb survivors with heavy weight. The mortality due to all causes of death combined, all malignant neoplasms, lung, and gastric cancer tended to become higher in a-bomb survivors who got married early. (Tsunoda, M.)

  9. Late effects of atomic bomb radiation on human immune responses, (10)

    International Nuclear Information System (INIS)

    Kusunoki, Yoichiro; Kyoizumi, Seishi; Ozaki, Kyoko; Saito, Mayumi; Cologne, J.B.; Akiyama, Mitoshi

    1992-01-01

    Anti-Epstein-Barr (EV) virus antibody titers were measured in age- and sex-matched three groups of each 124 A-bomb survivors who had exposed to 1 Gy. These serum samples showed positive antibodies against viral capsid antigens (VCA). Antibody titers to anti-VCA-IgM or anti-EA-IgG were significantly higher in the groups of 0.01-1 Gy and >1 Gy than in the group of <0.01 Gy, reflecting decreased immune response ability for EV virus. When precursor frequency of cytotoxic cells against autologous EB virus LCL was determined in 68 other A-bomb survivors, no definitive influence of A-bombing was observed. However, serological study revealed that there was inverse correlation between precursor frequency and anti-EA-IgG antibody titer. These findings suggest that the immune response ability for EB virus may have been damaged and that biological reactivity of EB virus may occur frequently in A-bomb survivors. (N.K.)

  10. T-cell immunosenescence and inflammatory response in atomic bomb survivors.

    Science.gov (United States)

    Kusunoki, Yoichiro; Yamaoka, Mika; Kubo, Yoshiko; Hayashi, Tomonori; Kasagi, Fumiyoshi; Douple, Evan B; Nakachi, Kei

    2010-12-01

    In this paper we summarize the long-term effects of A-bomb radiation on the T-cell system and discuss the possible involvement of attenuated T-cell immunity in the disease development observed in A-bomb survivors. Our previous observations on such effects include impaired mitogen-dependent proliferation and IL-2 production, decreases in naive T-cell populations, and increased proportions of anergic and functionally weak memory CD4 T-cell subsets. In addition, we recently found a radiation dose-dependent increase in the percentages of CD25(+)/CD127(-) regulatory T cells in the CD4 T-cell population of the survivors. All these effects of radiation on T-cell immunity resemble effects of aging on the immune system, suggesting that ionizing radiation might direct the T-cell system toward a compromised phenotype and thereby might contribute to an enhanced immunosenescence. Furthermore, there are inverse, significant associations between plasma levels of inflammatory cytokines and the relative number of naïve CD4 T cells, also suggesting that the elevated levels of inflammatory markers found in A-bomb survivors can be ascribed in part to T-cell immunosenescence. We suggest that radiation-induced T-cell immunosenescence may result in activation of inflammatory responses and may be partly involved in the development of aging-associated and inflammation-related diseases frequently observed in A-bomb survivors.

  11. Epidemiology of large intestinal cancer in Nagasaki city with reference to atomic bomb exposure, 1973∼1982

    International Nuclear Information System (INIS)

    Kinoshita, Shingo; Shimokawa, Isao; Iwasaki, Keisuke; Sakai, Hidetaka; Matsuo, Takeshi; Ikeda, Takayoshi; Mori, Hiroyuki; Mine, Mariko

    1988-01-01

    Epidemiological studies were conducted on 1098 cases of large intestinal cancer (615 cases of colon cancer and 483 cases of rectum cancer) registered at the Nagasaki Tumor Registry from 1973 to 1982, with emphasis on the relation to radiation exposure. The incidence in atomic bomb survivors was not significantly different from that in non-exposed persons, but the incidence in persons exposed at a young age tends to be higher, particularly the incidence of colon cancer in females. By site, about 56% of all colorectal cases investigated were shown to originate in the colon. In the colon, sigmoid cancer was the most frequent in both males and females, but there was no difference with regard to exposure status. In a comparison of the incidence during the first and second halves of the period examined, colorectal cancer revealed a general increasing trend, particularly for colon cancer in males and rectum cancer in females. Histologically, over 90% was differentiated adenocarcinoma and showed no difference by age, sex or exposure status. Nevertheless, it is noteworthy that musinous carcinoma was more frequent in atomic bomb survivors than in non-exposed people. Further analysis of the incidence, site and histologic type of colorectal cancer, especially in the group exposed at a young age, is necessary. (author)

  12. Bombing of Hiroshima and Nagasaki: a test or tragedy ?

    International Nuclear Information System (INIS)

    Faridah Mohd Idris

    2003-01-01

    Hiroshima and Nagasaki were left as monument by the history of the man civilization. This article discussed some of related issues i.e. the scenarios of the tragedy, the history of atomic bomb - starts with the discovery of neutrons to the day the tragedy happened

  13. Late effects of atomic bomb radiation on human immune responses, (5)

    International Nuclear Information System (INIS)

    Kusunoki, Yoichiro; Kyoizumi, Seishi; Fujita, Shoichiro; Akiyama, Mitoshi

    1989-01-01

    Natural killer (NK) and lymphokine-activated killer (LAK) activities were determined in peripheral lymphocytes from 62 A-bomb survivors, with the purpose of evaluating their relation to age, sex, and estimated exposure doses (DS86). NK activity in fresh lymphocytes was significantly higher in men than women; a significantly increased activity was associated with aging. However, LAK activity, obtained on the culture medium in the presence of IL-2, was independent of sex and aging. These findings suggest that the cell group involved in LAK activity may be different from that involved in NK activity. The present series failed to reveal the influences of A-bombing on both NK and LAK activities. (N.K.)

  14. Why 159°?: a story about the dropping of the Hiroshima atom bomb

    Science.gov (United States)

    Prunty, Sean L.

    2015-04-01

    This paper presents an analysis of the evasive manoeuvre undertaken by the pilot of the Enola Gay aircraft following the dropping of the first uranium bomb. The pilot was instructed to make a 159° turn following the bomb’s release in order to acquire the greatest distance from the point at which the bomb explodes. Accordingly, the objective here is to investigate why the angle should be exactly 159°. The optimum flight-path to maximize the distance from the detonation point is analysed by considering the escape or exit angle taken by the aircraft following a turning-manoeuvre that points it directly away from the detonation site. A range of escape angles are predicted based on the requirement to exit the turning radius prior to detonation. By using information that appeared in a historical account of the event regarding the manoeuvre undertaken by the pilot following the release of the bomb, an estimate is made of the escape angle. Despite the fact that the result shows reasonable agreement with the value of 159°, some uncertainty is expressed as to the close coincidence obtained. In addition, the location of the aircraft and the time of arrival of the shock wave following detonation are also briefly discussed.

  15. A search for genetic effects of atomic bomb radiation on the growth and development of the F1 generation, 2

    International Nuclear Information System (INIS)

    Furusho, Toshiyuki; Otake, Masanori.

    1978-08-01

    A comparative study to detect possible genetic effects of atomic bomb radiation on the growth and development of offspring of A-bomb survivors was made on a group of senior high school students 15 to 17 years of age born to survivors and to nonexposed parents in Hiroshima using as variables weight, sitting height, and chest circumference. Using data from students born to nonexposed parents, regression analysis was made to determine the effect of parental age on the weight, sitting height, and chest circumference of the offspring, but no statistically significant relation was observed. The mean and variance values of weight, sitting height, and chest circumference of offspring of nonexposed parents were compared to those of offspring born to exposed father and nonexposed mother, and of offspring born to exposed mother and nonexposed father, but very few statistically significant differences were found. The mean and variance values of weight, sitting height, and chest circumference of offspring born to nonexposed parents were compared to those of offspring born to parents both exposed, and again there were very few statistically significant differences. No specific tendency was observed in relation to the combined radiation dose of both parents. (author)

  16. Nagasaki and radiation. Health effects of radiation: atomic bomb, Chernobyl and JCO

    International Nuclear Information System (INIS)

    Nagataki, Shigenobu

    2005-01-01

    Under the title of Nagasaki and Radiation, this presentation will include the significance of the investigation of health of radiation on A-bomb survivors, dissociation between the scientific results and the public impression at the Chernobyl accident and problems in health control of the people in the regions surrounding JCO, Tokaimura. It is proposed that in the area of the low-dose radiation, economic, ethical, psychological, environmental, and scientific factors are all essential in the policy and regulatory decision-making process to assure public health and well-being. (author)

  17. Liver cancer in atomic-bomb survivors. Histological characteristics and relationships to radiation and hepatitis B and C viruses

    International Nuclear Information System (INIS)

    Fukuhara, Toshiyuki; Sharp, G.B.; Mizuno, Terumi

    2001-01-01

    Histological features of primary liver cancer among atomic-bomb survivors and their relationship to hepatitis B (HBV) and C viral (HCV) infections are of special interest because of the increased risk of liver cancer in persons exposed to ionizing radiation and the high and increasing liver cancer rates in Japan and elsewhere. We conducted a pathology review of liver cancers occurring from 1958 to 1987 among subjects in the 120,321 member cohort of 1945 Hiroshima and Nagasaki residents. A panel of pathologists classified tumor histological types and defined accompanying cirrhotic changes of the liver. Archival tissue samples were assessed for HBV using pathology stains and PCR. Reverse transcriptase (RT) PCR was used to determine HCV status. We used unconditional logistic regression to compare 302 hepatocellular carcinoma (HCC) cases to 53 cholangiocarcinoma (CC) cases, adjusting for age, year of diagnosis, sex and viral status. Cirrhotic changes occurred significantly more often among HCC than CC cases (76% in HCC and 6% in CC). Compared to CC cases, HCC cases were 10.9 times more likely to be HBV-positive (95% confidence interval: 2.1-83.2) and 4.3 times more likely to be HCV-positive (95% confidence interval: 1.1-20.5) No significant differences were found between HCC and CC cases in radiation exposures. The predominance of HCC in the atomic-bomb survivors follows the background liver cancer pattern in Japan. Our findings suggest that HBV and HCV are involved in the pathogenesis of HCC with or without cirrhosis and are significantly less important in that of CC. (author)

  18. Molecular basis of basal cell carcinogenesis in the atomic-bomb survivor population: p53 and PTCH gene alterations.

    Science.gov (United States)

    Mizuno, Terumi; Tokuoka, Shoji; Kishikawa, Masao; Nakashima, Eiji; Mabuchi, Kiyohiko; Iwamoto, Keisuke S

    2006-11-01

    Epidemiological studies suggest that UV exposure from sunlight is the major etiology for skin cancers, both melanocytic and non-melanocytic. However, the radiation-related risk for skin cancer among atomic bomb survivors of Hiroshima and Nagasaki is primarily derived from the excess risk of basal cell carcinoma (BCC), with no demonstrable excess in squamous cell carcinoma or melanoma. The BCCs in this cohort are therefore unusual in being potentially attributable to two types of radiation-UV and ionizing (IR). BCCs have been associated with PTCH and/or p53 tumor suppressor gene alterations. To investigate the roles of these genes in relation to IR and UV exposures, we analyzed both genes in BCC samples from atomic bomb survivors. We examined 47 tumors, of which 70% had non-silent base-substitution p53 mutations independent of IR or UV exposure. However, the distribution of mutation type depends on UV and/or IR exposure. For example, C-to-T transitions at CpG sites adjacent to pyrimidine-pyrimidine (PyPy) sequences were more prevalent in tumors from UV-exposed than UV-shielded body areas and CpG-mutations at non-PyPy sequences were more prevalent in tumors from UV-shielded body areas with high-IR (>or=1 Gy) than low-IR (<0.2 Gy) exposure. And notably, although p53 deletion-frequencies demonstrated no IR-dose associations, deletions at the PTCH locus were more frequent (79% versus 44%) in tumors with high-IR than low-IR exposure. Moreover, 60% of high-IR tumors harbored both p53 and PTCH abnormalities compared with 23% of low-IR tumors. Therefore, alteration of both genes is likely to play a role in radiation-induced basal cell carcinogenesis.

  19. Pairing :from atomic nuclei to neutron-star crusts

    OpenAIRE

    Chamel, Nicolas; Pearson, Michael J.; Goriely, Stéphane

    2013-01-01

    Nuclear pairing is studied both in atomic nuclei and in neutron-star crusts in the unified framework of the energy-density functional theory using generalized Skyrme functionals complemented with a local pairing functional obtained from many-body calculations in homogeneous nuclear matter using realistic forces.

  20. The radioecological consequences after explosion of the most powerful atomic bomb over Novaya Zemlya

    International Nuclear Information System (INIS)

    Chugunov, V.V.; Ramzaev, P.V.

    1995-01-01

    On the 30 October 1961 an H-bomb of 50 MT TNT-equivalent was exploded at a height of 3.5 km over Novaya Zemlya. This explosion required the expert inspection of the most important regions of Russia Arctic to enforce the system of population radiation safety. It was necessary to inspect 10,000 km of coast and to assess the situation in towns and settlements of the main provinces, districts and autonomous republics. The scientific tasks included aerogamma survey and collection of air and snow samples, samples of local food, daily ration, soil, vegetables and autopsy material. The radioactivity of samples was measured and extensive contaminated material was obtained. Some of the data of importance regarding observed radioactivity in air, lichens, reindeer bones, permanent reindeer meat consumers and vegetables are presented in the present report. 1 fig

  1. A case of refractory anemia with chromosomal abnormality (5q-) in Nagasaki atomic bomb survivor

    International Nuclear Information System (INIS)

    Kusano, Miyuki; Ikeda, Shuichi; Tomonaga, Yu; Sadamori, Naoki; Matsunaga, Masako

    1978-01-01

    Although assumed to be almost free from the effect of A-bomb radiation on the basis of the estimated dose, this case had progressive anemia with a specific manifestation and disclosed a clone with chromosomal abnormality (5q - ). In pure leukemia, a clone of abnormal chromosome is considered exactly that of leukemia. However, the presence of clones with chromosomal abnormality which are found in polycythemia vera or myelofibrosis do not always denote the leukemic changes. There is no established theory as to the significance of the clones with chromosomal abnormality in refractory anemia. Thus the interpretation of chromosomal abnormality in blood diseases is very difficult. Therefore analysis of chromosomes will be made actively in leukemia and related diseases as well as refractory anemia and preleukemia, and those will be compared in detail to search the relation between on occurrence of leukemia and chromosomal abnormality and also that between chromosomal abnormality and exposure to radiation. (Ueda, J.)

  2. Clonally expanded T lymphocytes from atomic bomb survivors in vitro show no evidence of cytogenetic instability.

    Science.gov (United States)

    Hamasaki, K; Kusunoki, Y; Nakashima, E; Takahashi, N; Nakachi, K; Nakamura, N; Kodama, Y

    2009-08-01

    Abstract Genomic instability has been suggested as a mechanism by which exposure to ionizing radiation can lead to cancer in exposed humans. However, the data from human cells needed to support or refute this idea are limited. In our previous study on clonal lymphocyte populations carrying stable-type aberrations derived from A-bomb survivors, we found no increase in the frequency of sporadic additional aberrations among the clonal cell populations compared with the spontaneous frequency in vivo. That work has been extended by using multicolor FISH (mFISH) to quantify the various kinds of chromosome aberrations known to be indicative of genomic instability in cloned T lymphocytes after they were expanded in culture for 25 population doublings. The blood T cells used were obtained from each of two high-dose-exposed survivors (>1 Gy) and two control subjects, and a total of 66 clonal populations (36 from exposed and 30 from control individuals) were established. For each clone, 100 metaphases were examined. In the case of exposed lymphocytes, a total of 39 additional de novo stable, exchange-type aberrations [translocation (t) + derivative chromosome (der)] were found among 3600 cells (1.1%); the corresponding value in the control group was 0.6% (17/3000). Although the ratio (39/3600) obtained from the exposed cases was greater than that of the controls (17/3000), the difference was not statistically significant (P = 0.101). A similar lack of statistical difference was found for the total of all structural chromosome alterations including t, der, dicentrics, duplications, deletions and fragments (P = 0.142). Thus there was no clear evidence suggesting the presence of chromosome instabilities among the clonally expanded lymphocytes in vitro from A-bomb survivors.

  3. Reassessment of diagnosis and subtyping of leukemias among atomic bomb survivors, 4

    International Nuclear Information System (INIS)

    Tomonaga, Masao; Kuriyama, Kazutaka; Ichimaru, Michito; Matsuo, Tatsuki; Finch, S.C.; Imanaka, Fumio; Kuramoto, Atsushi; Kamada, Nanao.

    1988-01-01

    In evaluable 456 (60 %) of 750 leukemic patients exposed at ≤9,000 m from the hypocenter, diagnosis and subtypes of leukemia were reevaluated in relation to radiation doses and age at the time of bombing using a new classification method of French-American-British (FAB). The FAB classification diagnosed 63 patients (13.5 %) as acute lymphoid leukemia (ALL), 181 (39.0 %) as acute myeloid leukemia (AML), 26 (5.6 %) as myelodysplastic syndrome (MDS), 106 (22.8 %) as chronic myeloid leukemia (CML), 39 (7.5 %) as adult T-cell leukemia, and 5 (0.8 %) as chronic lymphocytic leukemia. According to radiation doses, the incidence of CML increased in the group exposed to one to 99 cGy; the incidences of ALL and MDS increased in the group exposed to ≥100 cGy. The incidence of CML was definitively higher in Hiroshima than Nagasaki in all groups; this was noted in the group exposed to 0 cGy (approximately 2.5 times higher). The incidences of ALL and MDS showed a tendency to increase in proportion to radiation doses. In the group exposed to ≥100 cGy, the incidences of ALL, CML, and MDS increased in patients younger than 15 years, those aged 16 - 35 years, and those older than 36 years, respectively, at the time of the bombing. In this group, there were also differences in latent period (10 yr in ALL and CML, 15 yr in AML, and 17 yr in MDS). None of the AML patients in the group exposed to ≥100 cGy had M3. (Namekawa, K.)

  4. Bombs, Bosons and Beer Cans-Research at the Los Alamos Neutron Science Center

    Science.gov (United States)

    Pynn, Roger

    1997-04-01

    The neutron scattering community is justifiably proud of the contributions it has made to basic research in many areas of science. Information obtained using neutrons has contributed strongly to our basic understanding of phenomena in diverse systems of interest to physicists, chemists and biologists - think, for example, of how little we would know about excitations in quantum fluids, the spin-density-wave state of chromium, electronic back-donation in the bonding of organometallic compounds, or the conformation of proteins and DNA in nucleosomes without neutron scattering. However, illustrious as this history of neutron scattering may be, it is not the only type of contribution neutrons have made to our modern scientific and technological enterprise. Increasingly in recent years, we have witnessed the application of neutrons to later parts of the R&D cycle, to problems that have been called ''strategic research'' and even in areas that are ''applied research'' or ''product development''. The purpose of my talk at this meeting is to illustrate this aspect of research at spallation neutron sources, using examples of work that has been done at the Los Alamos Neutron Science Center (LANSCE). Some of this work is driven by the fact that our principal funding agency, the Office of Defense Programs within the U.S. Department of Energy, has a need to master the science behind technologies relevant to nuclear weapons. Even so, most of the examples I have picked are equally relevant to the industrial sector and several would not shame even the most devout proponent of ''pure'' research. To demonstrate the breadth of the research performed at LANSCE, I will describe examples of recent experiments in the following areas: materials texture; temperature and particle velocity measurement in reacting high explosives; radiographic imaging with protons; chemical bonding in metal-dihydride complexes; and the structure of thin adhesive layers. LANSCE operates a user program and

  5. Report on the results of the twelfth medical examination of atomic bomb survivors residing in North America

    Energy Technology Data Exchange (ETDEWEB)

    Yamamoto, Yasuji [Hiroshima Prefectural Medical Association (Japan); Ohama, Koso; Fujiwara, Saeko (and others)

    2000-06-01

    The twelfth medical examination of atomic bomb survivors residing in North America, was conducted in San Francisco and Seattle from May 20 through June 2 1999, and in Los Angeles and Hawaii from June 9 through 23 1999, The examination included an interview, measurement of height, weight, and blood pressure, an ECG, urine and stool tests, blood tests, a physical examination, examination of the breast, thyroid, and rectum by a surgeon, and screening for uterine cancer and a gynecological interview and examination by an obstetrician and gynecologist. The total confirmed number of A-bomb survivors residing in North America as of the end of June 1999 was 1076. Of the 1062 survivors that remained after excluding the 14 subjects whose survey was incomplete, 279 males and 654 females had been exposed in Hiroshima, and 10 males and 119 females in Nagasaki. The peak age at the time of exposure in both sexes was 15-19 years, followed by 10-14 years. The number of survivors exposed <2000 m from the hypocenter was 236, accounting for 21.9% of the total. The confirmed number of survivors exposed in utero was 26. The survivors' age (mean {+-}S.D.) was: 69.0{+-}8.69 years; males, 68.4{+-}80.5 years; females, 69.2{+-}8.91 years. A total of 414 survivors were examined (male 129; female 285; mean age 68.0 years). Approximately 80% of the examinees had experienced at least one general symptom. Many still complain of symptoms that suggest possible posttraumatic stress disorder as a result of exposure to the A-bomb. It will be necessary to consider providing mental health care by psychiatrists beginning with the next examination. The prevalence of life-style diseases has been gradually increased with age. A previous history of cancer was found in 9.2% of the examinees. The most prevalent was of breast cancer, followed by malignant tumors of the colon, rectum, uterus, brain, stomach, and thyroid. The need for cancer screening and promotion of life-style education was keenly felt. (K.H.)

  6. Feasibility of using 236U to reconstruct close-in fallout deposition from the Hiroshima atomic bomb.

    Science.gov (United States)

    Sakaguchi, A; Kawai, K; Steier, P; Imanaka, T; Hoshi, M; Endo, S; Zhumadilov, K; Yamamoto, M

    2010-10-15

    The first results on the feasibility of using (236)U to reconstruct the level and spatial distribution of close-in fallout deposition from the Hiroshima A-bomb are reported, coupled with the use of global fallout (137)Cs and (239+240)Pu. The results for global fallout (236)U in soil samples (0-30cm) from Ishikawa prefecture showed that the deposition density of (236)U from the global fallout can be accurately evaluated using AMS. All deposited (236)U, (137)Cs and (239+240)Pu appeared to have been recovered using 30-cm cores. It was also noted from the depth profiles for (236)U/(239+240)Pu and (236)U/(137)Cs ratios that the downward behavior of (236)U in the soil was apparently similar to that of (239+240)Pu, while the (137)Cs was liable to be retained in upper layers compared with (236)U and (239+240)Pu. The accumulated levels were 1.78×10(13)atomsm(-2) for (236)U, 4340Bqm(-2) for (137)Cs and 141Bqm(-2) for (239+240)Pu. The ratios of (236)U/(137)Cs and (236)U/(239+240)Pu were (4.10±0.12)×10(9) and (1.26±0.04)×10(11)atomsBq(-1), respectively. Results of (236)U, (137)Cs and (239+240)Pu measurements for the seven soil cores (0-30cm) from Hiroshima were discussed on the basis of ratios of (236)U/(137)Cs and (236)U/(239+240)Pu by comparing with those from the background area in Ishikawa, indicating that the global fallout dominates the current level of (236)U accumulation in soil in the Black-rain area around Hiroshima after the Hiroshima bomb, and the contribution of the close-in fallout (236)U produced by the Hiroshima A-bomb seems difficult to observe. Copyright © 2010 Elsevier B.V. All rights reserved.

  7. Report on the results of the twelfth medical examination of atomic bomb survivors residing in North America

    International Nuclear Information System (INIS)

    Yamamoto, Yasuji; Ohama, Koso; Fujiwara, Saeko

    2000-01-01

    The twelfth medical examination of atomic bomb survivors residing in North America, was conducted in San Francisco and Seattle from May 20 through June 2 1999, and in Los Angeles and Hawaii from June 9 through 23 1999, The examination included an interview, measurement of height, weight, and blood pressure, an ECG, urine and stool tests, blood tests, a physical examination, examination of the breast, thyroid, and rectum by a surgeon, and screening for uterine cancer and a gynecological interview and examination by an obstetrician and gynecologist. The total confirmed number of A-bomb survivors residing in North America as of the end of June 1999 was 1076. Of the 1062 survivors that remained after excluding the 14 subjects whose survey was incomplete, 279 males and 654 females had been exposed in Hiroshima, and 10 males and 119 females in Nagasaki. The peak age at the time of exposure in both sexes was 15-19 years, followed by 10-14 years. The number of survivors exposed <2000 m from the hypocenter was 236, accounting for 21.9% of the total. The confirmed number of survivors exposed in utero was 26. The survivors' age (mean ±S.D.) was: 69.0±8.69 years; males, 68.4±80.5 years; females, 69.2±8.91 years. A total of 414 survivors were examined (male 129; female 285; mean age 68.0 years). Approximately 80% of the examinees had experienced at least one general symptom. Many still complain of symptoms that suggest possible posttraumatic stress disorder as a result of exposure to the A-bomb. It will be necessary to consider providing mental health care by psychiatrists beginning with the next examination. The prevalence of life-style diseases has been gradually increased with age. A previous history of cancer was found in 9.2% of the examinees. The most prevalent was of breast cancer, followed by malignant tumors of the colon, rectum, uterus, brain, stomach, and thyroid. The need for cancer screening and promotion of life-style education was keenly felt. (K.H.)

  8. Frequency of malignant tumors during the first two decades of life in the offspring (F1) of atomic bomb survivors

    International Nuclear Information System (INIS)

    Yoshimoto, Yasuhiko; Neel, J.V.; Kato, Hiroo; Mabuchi, Kiyohiko; Schull, W.J.; Soda, Midori; Eto, Ryozo.

    1990-05-01

    The incidence of cancer prior to age 20 has been determined in children born to atomic bomb survivors and to a suitable comparison group. Tumor ascertainment was through death certificates and the tumor registries maintained in Hiroshima and Nagasaki. The rationale for the study stemmed from the evidence that a significant proportion of childhood tumors such as retinoblastoma and Wilms' tumor arise on the basis of a mutant gene inherited from one parent plus a second somatic cell mutation involving the allele of this gene. Gonadal radiation doses were calculated using the recently established DS86 system, supplemented by an ad hoc system for those children whose parents' (one or both) DS86 dose could not be computed but for whom a dose could be developed on the basis of the available information. The total data set consisted of: 1) a cohort of 31,150 liveborn children, one or both of whose parents received ≥ 0.01 Sv of radiation at the time of the A-bombings (an average conjoint gonad exposure of 0.435 Sv), and 2) two suitable comparison groups, totaling 41,066 children. A total of 92 cancer cases at age less than 20 years was confirmed; 49 and 43 cases, respectively, in the 0 Sv and ≥ 0.01 Sv groups. A multiple linear regression analysis revealed no increase in malignancy in the children of exposed parents. However, examination of the data suggested that only 3.0 % to 5.0 % of the tumors of childhood observed in the comparison groups are associated with an inherited genetic predisposition that would be expected to exhibit an altered frequency if the parental mutation rate were increased. These is thus far no confirmation of the positive findings of Nomura in a mouse system. (author)

  9. Field Prototype of the ENEA Neutron Active Interrogation Device for the Detection of Dirty Bombs

    Directory of Open Access Journals (Sweden)

    Nadia Cherubini

    2016-10-01

    Full Text Available The Italian National Agency for New Technologies, Energy, and Sustainable Economic Development (ENEA Neutron Active Interrogation (NAI device is a tool designed to improve CBRNE defense. It is designed to uncover radioactive and nuclear threats including those in the form of Improvised Explosive Devices (IEDs, the so-called “dirty bombs”. The NAI device, at its current development stage, allows to detect 6 g of 235U hidden in a package. It is easily transportable, light in weight, and with a real-time response. Its working principle is based on two stages: (1 an “active” stage in which neutrons are emitted by a neutron generator to interact with the item under inspection, and (2 a “passive” stage in which secondary neutrons are detected originating a signal that, once processed, allows recognition of the offence. In particular, a clear indication of the potential threat is obtained by a dedicated software based on the Differential Die-Away Time Analysis method.

  10. An operated case with post-traumatic epilepsy following atomic bombing injury

    Energy Technology Data Exchange (ETDEWEB)

    Morioka, Takato; Nishio Shunji; Muraishi; Mitsuteru; Hisada, Kei; Takase, Keiichirou; Matsukado, Koichiro; Sasaki, Masayuki; Fukui, Masashi [Kyushu Univ., Fukuoka (Japan). Graduate School of Medicine; Ohta, Michiya

    1999-12-01

    The case was 54-years-old man who was bombed at 4-years old 1.5 km apart from the center of explosion in Hiroshima, and had intractable epilepsy after 10 years or more. He suffered from systemic convulsion from 18 years old and took anti-convulsant drugs from 23 years old. The frequency of seizure increased from once a half year to thrice 2 months for these 3-4 years. The attack mainly occurred at night, and it was generalized tonicoclonic convulsion accompanied with unconsciousness and urinary incontience. Valproate (1,800 mg) and clonazepam (1 mg) failed to control the attack, and then he was referred to author's hospital. By CT scanning, MRI and HMPAO-SPECT, the area around the ossified lesion in the right frontal lobe was considered the focus of the epilepsy, and the focus was removed on June 4, 1998. No neurodegeneration and convulsive seizure occurred after surgery. The ossified lesion was confirmed to be bone tissue containing osteoblasts from histological findings and was accompanied by severe gliosis to the brain surface. A large number of active astrocytes were found around the nerve cells in the cortex showing spine-like wave focus, but there were no significant changes in blood vessels in the brain. (K.H.)

  11. Genetic effects of atomic bomb radiation on growth of stature of F1 generation

    International Nuclear Information System (INIS)

    Furusho, Toshiyuki

    1976-01-01

    On the basis of the data on stature of high school students aged from 15 to 17 in Hiroshima Prefecture, exposed group was divided into two groups. One was both-parents exposed group and the other was one-parent only exposed group. Each group was subdivided into 1 rad > exposed group and 1 rad . However, the difference of fourth central moment and correlation showed no definite tendency. Difference of mean was minus in many children of the father exposed and mother non-exposed group, but was plus in the contrary group. In other groups, no definite tendency was found. Regression analysis of exposure dose of parents from mean value of children showed no particular results, including non-exposed group or not. However, minus regression coefficient was more frequently seen on statistically significant level. Estimated value of induced mutation rate of polygene by A-bomb radiation, which effected on stature per generation, site of polygene in co-ordinate and 1 rad, was very low. As it was, however, the estimated value per 1 rad, it seemed to be not necessarily low. Concerning on the induced mutation rate, similar results were obtained in both-parents exposed group and one-parent only exposed group. (Kanao, N.)

  12. A study of autoimmune thyroid disorder in atomic bomb survivors in Hiroshima, (3)

    Energy Technology Data Exchange (ETDEWEB)

    Noma, Koji; Sasaki, Hideo (National Kure Hospital, Hiroshima (Japan)); Ito, Chikako; Mito, Kazuyo; Kato, Masafumi; Egusa, Genji; Hara, Hitoshi

    1989-01-01

    To determine sequential changes in thyroid function after developing asymptomatic autoimmune thyroiditis (AAT) in A-bomb survivors, initial findings of thyrotropin-releasing hormone (TRH) test were compared with those 2 years after developing AAT (n=22) and struma (S) (n=12). According to Bastenie's classification, AAT or S patients were clinically staged into three grades. Among 17 patients who had initially had AAT I, one each developed Grade II and III two years later. Initial Grade II turned to Grade I at 2 years in 2 of 4 AAT patients and in 2 of 3 S patients. In both the AAT and S groups, Grade III remained unchanged two years later. There was no significant change in basal or peak thyroid stimulating hormone level between patients with Grade I and those with Grade II or III in both the AAT and S groups. There were no sequential changes in total and free T4, total and free T3, total cholesterol, triglyceride, and lactic dehydrogenase. The TRH test is unlikely to reflect the development of hypothyroidism. (N.K.).

  13. Study of autoimmune thyroid disorder in atomic bomb survivors in Hiroshima, (2)

    Energy Technology Data Exchange (ETDEWEB)

    Noma, Koji; Sasaki, Hideo; Ito, Chikako; Mito, Kazuyo; Kato, Masashi; Egusa, Gengi; Hara, Hitoshi

    1986-11-01

    To elucidate sequential changes of thyroid function in persons seropositive for anti-thyroid antibodies, thyrotropin releasing hormone (TRH) test was performed in 31 patients with asymptomatic autoimmune thyroiditis (AAT), 13 patients with struma (S), and 28 normal subjects. On the basis of basal TSH values, 26 of the AAT patients were classified as grade I, 4 as grade II, and 2 as grade III; and 8 of the S patients as grade I, 4 as grade II, and one as grade III. One patient with grade I AAT developed subclinical hypothyroidism (SHT). All grade III AAT and S patients were considered to have SHT. S patients were more likely than AAT patients to develop SHT. Regarding serum levels of total T4, total T3, total cholesterol, triglyceride, and lactic dehydrogenase, there was no significant correlation between grade I group and grade II + III group. Although the basal TSH value may be a somewhat important indicator for predicting thyroid function, abnormal basal TSH value returned to normal several years later even in the case of patients with increased value. There was no evidence that autoimmune thyroid disorder is frequent in A-bomb survivors exposed within 2,000 m from ground zero. (Namekawa, K.).

  14. From the atomic bomb to the Landau Institute autobiography top non-secret

    CERN Document Server

    Khalatnikov, Isaak M

    2012-01-01

    The book is an expanded autobiography of the famous theoretical physicist Isaak Khalatnikov. He worked together with L.D. Landau at the Institute for Physical Problems lead by P.L. Kapitza. He is the co-author of L.D. Landau in a number of important works. They worked together in the frame of the so-called Nuclear Bomb Project. After the death of L.D. Landau, I.M. Khalatnikov initiated the establishment of the Institute for Theoretical Physics, named in honour of L.D. Landau, within the USSR Academy of Sciences. He headed this institute from the beginning as its Director. The institute inherited almost all traditions of the Landau scientific school and played a prominent role in the development of theoretical physics. So, this is a story about how the institute was created, how it worked, and about the life of the physicists in the "golden age" of the Soviet science. A separate chapter is devoted to today´s life of the institute and the young generation of physicists working now in science. It is an historic...

  15. Estimation of risk map for cohort study of Hiroshima atomic bomb survivors. 1970-2010

    International Nuclear Information System (INIS)

    Tonda, Tetsuji; Satoh, Kenichi; Otani, Keiko; Sato, Yuya; Maruyama, Hirofomi; Kawakami, Hideshi; Tashiro, Satoshi; Hoshi, Masaharu; Ohtaki, Megu

    2012-01-01

    A risk map (map I) involving the effects of direct A-bomb exposure and of other confounding factors was estimated to analyze the death risk in the geographic distribution, and another risk map (map II) was also made by subtracting the direct exposure effect to see the confounder effect. The cohort was 37,382/157,327 survivors at Jan. 1, 1970, whose positional coordinates at the exposure were known, and was followed up until Dec. 31, 2009. For survival analysis, the endpoint was defined to be death (total 19,119) by regarding other 18,263 as censoring. Confounding factors were sex, age at the exposure, exposed dose and shielded condition. Maps I and II were depicted using the hazard ratio at the exposed position relative to the hypocenter, which was estimated by previously reported hazard model functions. Map I was found to be rather similar to concentric circle of the hypocenter, but to be tended a bit distorted toward northwest area. The distortion was clearer in the map II, indicating that death causes other than direct exposure existed. The confounder was thought to be the indirect exposure through the black rain, residual radiation and/or internal exposure, which awaiting future investigation. (T.T.)

  16. Synthetic medical studies on atomic bomb survivors exposed in short distances, 15

    International Nuclear Information System (INIS)

    Kamada, Nanao; Tanaka, Kimio; Kontani, Nobuko; Yokoro, Kenjiro; Takimoto, Yasuo; Kuramoto, Atsushi; Munaka, Masaki; Kurihara, Minoru; Hattori, Takao

    1988-01-01

    In an effort to search for biological significance of chromosome aberration observed in bone marrow cells and peripheral lymphocytes, the presence of transforming genes in the DNA of bone marrow cells was examined in four healthy A-bomb survivors (Group I), three with preleukemia (Group II), and nine with leukemia (Group III). In Group I exposed at 300 - 500 m from the hypocenter, estimated radiation doses ranged from 565 to 667 cGy; and randomly abnormal karyotypes ranged from 30.7 % to 48.3 %. In Group II exposed at 800 m, in which estimated radiation doses were 300 - 600 cGy, one survivor had a complicated karyotype abnormality; and in the two others, abnormal clones were partly observed. Group III, which was exposed at 800 - 2,000 m and had estimated doses of 20 - 200 cGy, consisted of acute lymphoid leukemia (one), acute myeloid leukemia (five), and chronic myeloid leukemia (three). The patient with acute lymphoid leukemia had a complicated karyotype abnormality. N-ras genes were observed not only in seven acute or chronic leukemic patients but also in three healthy survivors. This may have important implications for the mechanism of leukemic transformation. (Namekawa, K.)

  17. The LD50 associated with exposure to the atomic bombing of Hiroshima

    International Nuclear Information System (INIS)

    Fujita, Shoichiro; Kato, Hiroo; Schull, W.J.

    1989-01-01

    Data on a total of 7,593 persons in Hiroshima who were in 2,518 wooden Japanese houses and exposed to A-bomb within 1.6 km from the hypocenter have been used to estimate the LD 50/60 . The effect of radiation shielding for these people in particularly well-characterized in the new dosimetry system DS86. A range of values emerge, varying slightly with the method of estimation used. This range, derived from DS86 marrow doses, and based on a linear fit to equally weighted estimates of the probabilities of death at various doses, is 2.3-2.6 Gy. A linear estimate in which the probabilities of death at the various doses are weighted by the inverse of their variances is somewhat lower, 2.2 Gy. These values may be underestimates of actual LD 50/60 because of inclusion of deaths in the first day, and the severely injured (burns, trauma) who survived the first day but succumbed later to their injuries. (author)

  18. Brain abnormalities among the mentally retarded prenatally exposed atomic bomb survivors

    International Nuclear Information System (INIS)

    Schull, W.J.; Otake, Masanori; Nishitani, Hiromu; Hasuo, Kanehiro; Kobayashi, Takuro; Goto, Ikuo.

    1992-07-01

    An increased occurrence of severe mental retardation, with or without accompanying small head size, at specific gestational ages has been the most conspicuous effect on brain development of prenatal exposure to the bombings of Hiroshima and Nagasaki. A variety of biological mechanisms could be responsible for this finding, including cell killing and mismanaged neuronal migration. We describe here the findings on magnetic resonance imaging of the brains of five of these mentally retarded individuals, all of whom were exposed in the 8th through the 15th weeks following fertilization, the gestational period shown to be the most vulnerable to radiation-related damage. In the two cases exposed at the 8th or 9th week following fertilization, large areas of ectopic gray matter are seen, strong evidence of a failure of the neurons to migrate to their proper functional sites. The two individuals exposed in the 12th or 13th week show no readily recognized ectopic gray areas but do show mild macrogyria, which implies some impairment in the development of the cortical zone. Moreover, both have mega cisterna magna. Finally, the one individual seen who was exposed still later in development, in the 15th week, shows none of the changes seen in the other four individuals. This person's brain, though small, appears to have normal architecture. These findings are discussed in terms of the embryological events transpiring at the time of the prenatal exposure of these individuals to ionizing radiation. (author)

  19. Isotope ratios of (235)U/(238)U and (137)Cs/(235)U in black rain streaks on plaster wall caused by fallout of the Hiroshima atomic bomb.

    Science.gov (United States)

    Shizuma, Kiyoshi; Endo, Satoru; Fujikawa, Yoko

    2012-02-01

    Radiological investigations of fallout from the atomic bomb detonated over Hiroshima city on 6 August 1945 are important to estimate doses for inhabitants. The authors have analyzed the concentrations of (137)Cs, (235)U, and (238)U in streaks of black rain caused by the atomic bomb using gamma-ray spectroscopy and the ICP-QMS method. The black rain streaks were deposited on a plaster wall of a house located 3.7 km west of the hypocenter that has been kept in the same condition as after the rainfall. Cesium-137 ((137)Cs) was detected from black streak samples. Concentration of (137)Cs in the black rain streaks is twice as high as fallout deposition on the ground in this area. A (235)U/(238)U atom ratio of 0.00887 was found, which is higher than the natural ratio, reflecting the fact that the atomic bomb "Little Boy" used enriched uranium as fuel. The ratio (137)Cs/(235)U was determined to be 0.0091, which is about eight times higher than the estimated ratio of 0.00113 based on the fission yield.

  20. Severe mental retardation among the prenatally exposed survivors of the atomic bombing of Hiroshima and Nagasaki

    International Nuclear Information System (INIS)

    Otake, Masanori; Yoshimaru, Hiroshi; Schull, W.J.

    1988-05-01

    In March 1986, as a result of a comprehensive reevaluatioin of the exposures of the survivors of the A-bombing of Hiroshima and Nagasaki, a new method for the estimation of individual doses was introduced, termed the Dosimetry System 1986 (DS86). In the new system they are computed individually without the use generally of explicit, average correction factors and thus allow better for the scattering of radiant energy that occurs within tissues. The comparisons described here rest on the computed dose to the mother's uterus. The DS86 sample itself consists of 1,544 individuals (96.6 %) of the 1,598 belonging to the clinical sample on whom T65DR doses are available. A variety of models with and without a threshold have been fitted to the individual as well as grouped dose data to ascertain the most suitable dose-response relationship. Briefly the findings of this comparison are as follows: The risk of severe mental retardation due to radiation exposure changes little from one dosimetric system to the other. The highest risk of radiation damage to the embryonic and fetal brain occurs 8 - 15 weeks after fertilization under both the T65DR and DS86 systems. Somewhat more evidence exists under the DS86 system of a threshold to the dose-response relationship in the 8 - 15 week interval than existed with the T65DR doses. However, the location and reality of the threshold are difficult to assess. Damage to the fetus 16 - 25 weeks after fertilization seems linear-quadratically or quadratically related to dose, especially in the DS86 sample, and suggests a threshold in the neighborhood of 0.70 Gy (DS86 dose), under a linear model using the individual dose data, with a lower 95 % confidence bound of 0.21 Gy. Grouped dose data give the same lower bound, but an estimate of the threshold of 0.64 Gy. (author)

  1. Proceeding by joint action: defending fundamental rights - no to the neutron bomb - demanding disarmament

    International Nuclear Information System (INIS)

    Anon.

    1978-01-01

    The US defence policy is not only directed against socialist countries but also against the interests of our country. Due to the planned emplacement of the neutron weapon in the Federal Republic of Germany, vigurous opposition of all those interested in peace is needed. The banning of nuclear weapons in east and west has to be our objective. The Federal Government has to cut defence spending, to exercise positive influence on MBFR-talks in Vienna, on the realization of the Final Act of Helsinki and has to actively support disarmament initiatives in the general assembly of the UN. (HSCH) [de

  2. A longitudinal study of growth and development among prenatally exposed atomic-bomb survivors

    International Nuclear Information System (INIS)

    Otake, Masanori; Fujikoshi, Yasunori; Schull, W.J.; Izumi, Shizue.

    1994-05-01

    Growth retardation due to A-bomb exposure has been evaluated for 455 individuals with nine repeated measurements of stature at age 10-18 yr using growth curve analysis and either two covariates, Dosimetry System 1986 (DS86) uterine absorbed dose and postovulatory age (weeks), or three covariates, DS86 uterine dose, DS86 uterine dose squared, and postovulatory age. Of the several comparisons made by city, sex, DS86 dose, and postovulatory age, the largest significant difference was found. However, on the basis of a linear-quadratic (L-Q) dose response, no significant difference was found. A highly significant growth retardation due to DS86 uterine absorbed dose was observed for all trimesters combined and for the first and second trimesters. In the first trimester, all parameter estimates based on a linear (L) or L-Q dose-response relationship were negative in relation to DS86 uterine absorbed dose. The parameter estimates in the second trimester were negative for a constant term and positive for an L or L-Q term. Radiation-related growth retardation at age 10-18 yr is clearly evident. The dose effect in the third trimester was not significant with either the L or the L-Q model. A growth analysis, based on an L dose-response relationship, was made for 704 and 838 children with four repeated measurements of stature from ages 10-13 and 15-18 yr, respectively. The retardation effect is clearly evident at age 10-13 and continues at age 15-18. Growth retardation in age 10-13 was highly significant for all trimesters combined but suggestive only for the first trimester. The group age 15-18 revealed a highly significant growth retardation for both the first and second trimesters. The relationship between birth weights and repeated measurements of stature in adolescence was discussed on the basis of the results obtained by a growth curve analysis. (J.P.N.)

  3. Estimation of beta-ray skin dose from exposure to fission fallout from the Hiroshima atomic bomb.

    Science.gov (United States)

    Endo, Satoru; Tanaka, Kenichi; Shizuma, Kiyoshi; Hoshi, Masaharu; Imanaka, Tetsuji

    2012-03-01

    Beta-ray skin dose due to the fission fallout from the Hiroshima atomic bomb is potentially related to the epilation in the black rain area. The absorbed dose to the skin from beta-rays emitted by fission fallout has been estimated for an initial ¹³⁷Cs deposition of 1 kBq m⁻² on the ground at 0.5 h after the explosion. The estimated skin dose takes into account both external exposure from fission fallout radionuclides uniformly distributed in 1 mm of soil on the surface of the ground and from a 26 μm thickness of contaminated soil on the skin, using the Monte Carlo radiation transport code MCNP-4C. The cumulative skin dose for 1 month after the explosion is taken as the representative value. The estimated skin dose for an initial ¹³⁷Cs deposition of 1 kBq m⁻² was determined to be about 500 mSv.

  4. Study of the titers of Anti-Epstein-Barr virus antibodies in the sera of atomic bomb survivors

    International Nuclear Information System (INIS)

    Akiyama, Mitoshi; Kusunoki, Yoichiro; Kyoizumi, Seishi; Ozaki, Kyoko; Mizuno, Shoichi; Cologne, J.B.

    1993-01-01

    Antibody titers to Epstein-Barr virus antigens were determined in the sera of 372 atomic bomb survivors to evaluate the effect of the previous radiation exposure on immune competence against the latent infection of the virus. The proportion of persons with high titers (≥ 1:40) of IgG antibodies to the early antigen was significantly elevated in the exposed survivors. Furthermore, the distribution of IgM titers against the viral capsid antigen was significantly affected by radiation dose with an increased occurrence of titers of 1:5 and 1:10 in the exposed persons, although the dose effect was only marginally suggestive when persons with rheumatoid factor were eliminated from the analysis. These results suggest that reactivation of Epstein-Barr virus in the latent stage occurs more frequently in the survivors, even though this might not be affected by the radiation dose. Otherwise, there was neither an increased trend in the prevalence of high titers (≥ 1:640) of IgG antibodies to the viral capsid antigen among the exposed people nor a correlation between the radiation exposure and distributions of titers of IgA antibodies to the viral capsid antigen or antibodies to the anti-Epstein-Barr virus-associated nuclear antigen. (author)

  5. Report on the result of the eighth medical examination of atomic bomb survivors in the South America

    Energy Technology Data Exchange (ETDEWEB)

    Ohta, Michiya [Hiroshima Red Cross Hospital (Japan); Ishioka, Shinichi; Hayakawa, Tohru; Kawano, Michimura; Sasaki, Yoshioki; Hirakami, Kojiro

    1999-05-01

    The atomic bomb survivors emigrating in the South America were 189 in total (160 in Brazil, 4 in Paraguay, 8 in Bolivia, 14 in Argentina and 3 in Peru) in November, 1998. Ninety-three persons (49%) took a medical examination (72 in Brazil, 3 in Paraguay, 6 in Bolivia, 9 in Argentina and 3 in Peru). The mean age was 68.6 years in male, and 68.1 years in female. They had hypertension (21.5%), diabetes (8.6%), cancer (6.5%), heart disease (5.4%), and thyroid gland diseases (4.3%). The subjective symptoms with high frequency were complete exhaustion or fatigue (58.1%), loss of vigor (55.9%), heat intolerance (49.5%) and numbness or tingling (47.1%). Electrocardiogram abnormality, total protein decrement, hypercholesterolemia and corpulence were almost the same as the last time. There was no change of a ratio of persons who needed tests on treatments. (K.H.)

  6. Report on the result of the eighth medical examination of atomic bomb survivors in the South America

    International Nuclear Information System (INIS)

    Ohta, Michiya; Ishioka, Shinichi; Hayakawa, Tohru; Kawano, Michimura; Sasaki, Yoshioki; Hirakami, Kojiro

    1999-01-01

    The atomic bomb survivors emigrating in the South America were 189 in total (160 in Brazil, 4 in Paraguay, 8 in Bolivia, 14 in Argentina and 3 in Peru) in November, 1998. Ninety-three persons (49%) took a medical examination (72 in Brazil, 3 in Paraguay, 6 in Bolivia, 9 in Argentina and 3 in Peru). The mean age was 68.6 years in male, and 68.1 years in female. They had hypertension (21.5%), diabetes (8.6%), cancer (6.5%), heart disease (5.4%), and thyroid gland diseases (4.3%). The subjective symptoms with high frequency were complete exhaustion or fatigue (58.1%), loss of vigor (55.9%), heat intolerance (49.5%) and numbness or tingling (47.1%). Electrocardiogram abnormality, total protein decrement, hypercholesterolemia and corpulence were almost the same as the last time. There was no change of a ratio of persons who needed tests on treatments. (K.H.)

  7. Long term effects of radiation exposure on telomere lengths of leukocytes and its associated biomarkers among atomic-bomb survivors.

    Science.gov (United States)

    Lustig, Ana; Shterev, Ivo; Geyer, Susan; Shi, Alvin; Hu, Yiqun; Morishita, Yukari; Nagamura, Hiroko; Sasaki, Keiko; Maki, Mayumi; Hayashi, Ikue; Furukawa, Kyoji; Yoshida, Kengo; Kajimura, Junko; Kyoizumi, Seishi; Kusunoki, Yoichiro; Ohishi, Waka; Nakachi, Kei; Weng, Nan-Ping; Hayashi, Tomonori

    2016-06-28

    Ionizing radiation (IR) is a major source of cellular damage and the immediate cellular response to IR has been well characterized. But the long-term impact of IR on cell function and its relationship with aging are not known. Here, we examined the IR effects on telomere length and other biomarkers 50 to 68 years post-exposure (two time points per person) in survivors of the atomic bombing at Hiroshima during WWII. We found that telomere length of leukocytes was inversely correlated with the dose of IR (p=0.008), and this effect was primarily found in survivors who were exposed at younger ages; specifically those <12 years old (p=0.0004). Although a dose-related retardation of telomere shortening with age was observed in the cross-sectional data, longitudinal follow-up after 11 years did not show IR exposure-related alteration of the rate of telomere shortening with age. In addition, IR diminished the associations between telomere length and selected aging biomarkers that were observed in survivors with no dose. These included uric acid metabolism, cytokines, and blood T cell counts. These findings showed long-lasting detrimental effects of IR on telomere length of leukocytes in both dose- and age-at-exposure dependent manner, and on alterations of biomarkers with aging.

  8. Perinatal loss and neurological abnormalities among children of the atomic bomb. Nagasaki and Hiroshima revisited, 1949 to 1989

    International Nuclear Information System (INIS)

    Yamazaki, J.N.; Schull, W.J.

    1990-01-01

    Studies of the survivors of the atomic bombing of Hiroshima and Nagasaki who were exposed to ionizing radiation in utero have demonstrated a significant increase in perinatal loss and the vulnerability of the developing fetal brain to injury. These studies have also helped to define the stages in the development of the human brain that are particularly susceptible to radiation-related damage. Exposure at critical junctures in development increases the risk of mental retardation, small head size, subsequent seizures, and poor performance on conventional tests of intelligence and in school. The most critical period, 8 through 15 weeks after fertilization, corresponds to that time in development when neuronal production increases and migration of immature neurons to their cortical sites of function occurs. The epidemiologic data are, however, too sparse to settle unequivocally the nature of the dose-response function and, in particular, whether there is or is not a threshold to damage. If a threshold does exist, it appears to be in the 0.10- to 0.20-Gy fetal-dose range in this vulnerable gestational period

  9. Inverse associations between obesity indicators and thymic T-cell production levels in aging atomic-bomb survivors.

    Directory of Open Access Journals (Sweden)

    Kengo Yoshida

    Full Text Available Reduction of the naive T-cell population represents a deteriorating state in the immune system that occurs with advancing age. In animal model studies, obesity compromises the T-cell immune system as a result of enhanced adipogenesis in primary lymphoid organs and systemic inflammation. In this study, to test the hypothesis that obesity may contribute to the aging of human T-cell immunity, a thousand atomic-bomb survivors were examined for obesity status and ability to produce naive T cells, i.e., T-cell receptor excision circle (TREC numbers in CD4 and CD8 T cells. The number of TRECs showed a strong positive correlation with naive T cell numbers, and lower TREC numbers were associated with higher age. We found that the TREC number was inversely associated with levels of obesity indicators (BMI, hemoglobin A1c and serum CRP levels. Development of type-2 diabetes and fatty liver was also associated with lower TREC numbers. This population study suggests that obesity with enhanced inflammation is involved in aging of the human T-cell immune system. Given the fact that obesity increases the risk of numerous age-related diseases, attenuated immune competence is a possible mechanistic link between obesity and disease development among the elderly.

  10. Inverse associations between obesity indicators and thymic T-cell production levels in aging atomic-bomb survivors.

    Science.gov (United States)

    Yoshida, Kengo; Nakashima, Eiji; Kubo, Yoshiko; Yamaoka, Mika; Kajimura, Junko; Kyoizumi, Seishi; Hayashi, Tomonori; Ohishi, Waka; Kusunoki, Yoichiro

    2014-01-01

    Reduction of the naive T-cell population represents a deteriorating state in the immune system that occurs with advancing age. In animal model studies, obesity compromises the T-cell immune system as a result of enhanced adipogenesis in primary lymphoid organs and systemic inflammation. In this study, to test the hypothesis that obesity may contribute to the aging of human T-cell immunity, a thousand atomic-bomb survivors were examined for obesity status and ability to produce naive T cells, i.e., T-cell receptor excision circle (TREC) numbers in CD4 and CD8 T cells. The number of TRECs showed a strong positive correlation with naive T cell numbers, and lower TREC numbers were associated with higher age. We found that the TREC number was inversely associated with levels of obesity indicators (BMI, hemoglobin A1c) and serum CRP levels. Development of type-2 diabetes and fatty liver was also associated with lower TREC numbers. This population study suggests that obesity with enhanced inflammation is involved in aging of the human T-cell immune system. Given the fact that obesity increases the risk of numerous age-related diseases, attenuated immune competence is a possible mechanistic link between obesity and disease development among the elderly.

  11. Exact solutions of the clonal expansion model and their application to the incidence of solid tumors of atomic bomb survivors

    International Nuclear Information System (INIS)

    Heidenreich, W.F.; Jacob, P.; Paretzke, H.G.

    1997-01-01

    We derive explizit hazard functions for the clonal expansion model in the ''exact formulation'' and in the ''epidemiological approximation'' for the spontaneous rate and for short-time exposure. We investigate which combination of the biological parameters can be determined from the incidence function, and which cannot. We then analyze the incidence data of all solid tumors of atomic bomb survivors (1958-1987). We restrict ourselves to adults at exposure (>20 years) and to attained age <80 years, and we consider the two cities (Hiroshima and Nagasaki) and the two sexes separately. With four parameters, we find good fits in each case, comparable to the quality of fit of epidemiological age-at-exposure and age-attained models used for comparison. The parameters which describe the spontaneous risk agree very well for the two cities, while they are quite different for the two sexes. The apparent flattening of the risk for elderly men can be described with the exact formulation of the clonal expansion model, but may be due to other causes than the mechanisms modeled. The dose-response parameters differ by more than two standard deviations (factor 2 to 3) between the two cities, when considering the same sex. They are bigger for the men of Nagasaki and the women of Hiroshima. One example for model application to tumors of specific organs (men's lung tumor) is considered. (orig.). With 15 figs., 4 tabs

  12. Investigation on circular asymmetry of geographical distribution in cancer mortality of Hiroshima atomic bomb survivors based on risk maps: analysis of spatial survival data

    International Nuclear Information System (INIS)

    Tonda, Tetsuji; Satoh, Kenichi; Otani, Keiko; Ohtaki, Megu; Sato, Yuya; Maruyama, Hirofumi; Kawakami, Hideshi; Tashiro, Satoshi; Hoshi, Masaharu

    2012-01-01

    While there is a considerable number of studies on the relationship between the risk of disease or death and direct exposure from the atomic bomb in Hiroshima, the risk for indirect exposure caused by residual radioactivity has not yet been fully evaluated. One of the reasons is that risk assessments have utilized estimated radiation doses, but that it is difficult to estimate indirect exposure. To evaluate risks for other causes, including indirect radiation exposure, as well as direct exposure, a statistical method is described here that evaluates risk with respect to individual location at the time of atomic bomb exposure instead of radiation dose. In addition, it is also considered to split the risks into separate risks due to direct exposure and other causes using radiation dose. The proposed method is applied to a cohort study of Hiroshima atomic bomb survivors. The resultant contour map suggests that the region west to the hypocenter has a higher risk compared to other areas. This in turn suggests that there exists an impact on risk that cannot be explained by direct exposure. (orig.)

  13. Distribution of onset of leukemia among atomic bomb survivors in the leukemia registry by dose, Hiroshima and Nagasaki, 1946-75

    International Nuclear Information System (INIS)

    Ishimaru, Toranosuke; Ichimaru, Michito; Mikami, Motoko; Yamada, Yasuaki; Tomonaga, Yuu.

    1982-03-01

    The data from the RERF Leukemia Registry for the years 1946-75 were used to determine the distribution of onset of acute leukemia and chronic granulocytic leukemia among atomic bomb survivors in relation to city, dose, and age at the time of the bomb (ATB). A total of 509 confirmed leukemia cases (297 in Hiroshima and 212 in Nagasaki) have occurred among A-bomb survivors in the open populations of these cities in these years. Analysis revealed that the onset of both acute leukemia and chronic granulocytic leukemia tends to shift to earlier years with increasing dose in Hiroshima, but in Nagasaki, although the onset of both types of leukemia was earlier in the high dose group than in the low dose or control groups, the latter two groups did not differ. The distribution of onset of acute leukemia in the three dose groups also depended upon age ATB. While the distribution of onset of acute leukemia among those survivors whose age ATB was less than 30 differed significantly in the three dose classes, this tendency was not observed among those individuals whose age ATB was 30 years or more. For chronic granulocytic leukemia, the onset was shifted to earlier years in the high dose group than in the control group regardless of age ATB in Hiroshima. These findings support the pattern of leukemogenesis observed in A-bomb survivors in the Life Span Study sample, a fixed cohort, in relation to city, dose, age ATB, and years after exposure. (author)

  14. An overview of the cancer mortality data on the atomic bomb survivors

    International Nuclear Information System (INIS)

    Pierce, D.A.

    1989-11-01

    A brief description is given of the cancer mortality data at the Radiation Effects Research Foundation, with the aim of providing some general perspective on the extent of the excess cancer mortality, for those who may not be inclined to glean this information from the more comprehensive reports on the Life Span Study. In addition, a summary is given of the changes in dosimetry given by the recently installed DS86 system. Even a cursory view of these changes requires consideration of several factors; changes in air doses, in environmental and organ shielding factors, in the extent of the neutron component, and in effects of truncation of exposures at 6 Gy. Finally, a brief discussion is given of the evolution of radiogenic cancer risk estimates during the past 10-15 years. (author)

  15. Atomic rearrangements in ordered fcc alloys during neutron irradiation

    International Nuclear Information System (INIS)

    Kirk, M.A.; Blewitt, T.H.

    1978-01-01

    Three sets of experiments performed at Argonne National Laboratory over the past few years are described. These experiments deal with atomic rearrangements in the ordered alloys Ni 3 Mn and Cu 3 Au during fast and thermal neutron bombardment. The unique magnetic properties of ordered Ni 3 Mn are utilized to investigate radiation damage production mechanisms at low temperature (5 K) where defect migration is not possible and only disordering is observed. In the case of thermal neutron bombardment, the average recoil energy is about 450 eV and significant disordering due to [110] replacement collision sequences is observed. For fast neutron bombardment where typical recoil energies are 20 keV, significant random disordering is observed but no evidence for sizable replacement sequences is found. The bombardment of ordered Cu 3 Au by fast and thermal neutrons at higher temperature (approx. 150 0 C) is studied by electrical resistance techniques. Both ordering and disordering are observed and related to the number of migrating vacancies escaping from the high energy collision cascade

  16. Analysis of the DS86 atomic bomb radiation dosimetry methods using data on severe epilation

    International Nuclear Information System (INIS)

    Stram, D.O.; Mizuno, S.

    1989-01-01

    This report presents a reanalysis of the Hiroshima and Nagasaki data on severe epilation as an acute radiation effect using both the new DS86 and the old T65D dosimetries. The focus of the report is on several aspects of the data which have previously been examined by Jablon et al. The report examines the uniformity of epilation response across shielding category, across sex and age, and in terms of interactions between city, sex, age, and shielding category; it also investigates the apparent relative biological effectiveness (RBE) of neutrons in the DS86 dose compared with the T65D dose, using both within- and between-city information. In addition the report discusses evidence for nonlinearity in epilation response. The epilation response function exhibits nonlinearity in terms of both a marked increase in slope at about 0.75 Gy, and then, beginning at about 2.5 Gy, a leveling off and eventual decrease in response. The principal conclusions of the report are as follows. The use of the DS86 dosimetry rather than T65D increases the apparent RBE of neutrons compared with gamma dose from approximately 5 to 10. At these values of RBE the slope of the dose response, in a middle range from 0.75-2.5 Gy, is about 165% greater using DS86 than T65D. With respect to the interactions of sex, city, and shielding method, the size and significance of virtually all nonuniformities in epilation response seem using T65D are also evident with DS86. Additionally it seems difficult to find any evidence that DS86 is an improved predictor of epilation response over T65D. Finally, the fact that the nonlinearity in dose response and apparent actual downturn in epilation occurrence rate at the high end of dose is more striking with DS86 than with T65D is found to be due primarily to the common practice of truncating all T65D doses to 600 rad

  17. Ph1 chromosomes and bcr gene rearrangements in chronic myelocytic leukemia patients developed from atomic bomb survivors

    International Nuclear Information System (INIS)

    Tanaka, Kimio; Takechi, Miho; Shigeta, Chiharu; Sakatani, Keiko; Oguma, Nobuo; Kamada, Nanao; Takimoto, Yasuo; Kuramoto, Atsushi

    1989-01-01

    This study compared findings of chronic myelocytic leukemia (CML) in A-bomb survivors (n=8) developing CML within 10 years after the bombing and in non-exposed CML patients (n=14). Both Ph 1 chromosomes and bcr rearrangement were observed in all patients in both exposed and non-exposed groups. There was no significant difference in distribution sites of bcr rearrangement between the groups. These results suggest that bcr-abl chimera mRNA and chimera protein associated with Ph 1 chromosomes have an important role in the development of CML among A-bomb survivors, as well as among non-exposed patients. (N.K.)

  18. Some time dependent aspects of fast neutron induced atomic cascades

    International Nuclear Information System (INIS)

    Williams, M.M.R.

    1976-01-01

    Analytical results are obtained for the time-energy distribution of neutrons and the associated displaced atoms slowing down in an amorphous medium according to a general force law. Explicit results are given for the inverse power law, and applications to hard-sphere and Coulomb scattering are discussed. Complete results are obtained for the steady state energy distribution of particles arising from a primary knock-on, and from a neutron initiated cascade. The speed of the slowing down process is assessed by calculating the slowing down time of particles. Two different concepts of slowing down time are discussed, one based upon a density average and the other on a slowing down density average. It is shown that the latter definition is physically more realistic and mathematically simpler. (author)

  19. Health care or Atom bombs? Interest profiles connected to a science career in Sweden

    Directory of Open Access Journals (Sweden)

    Magnus Oskarsson

    2011-09-01

    Full Text Available The ROSE survey explores which science topics 15-year-old students want to study. By carrying out a factor analysis on results from Sweden it was possible to describe ten interest profiles. The interest profile with the strongest connection to the students’ interest in school science consists of topics such as explosive chemicals, ABC weapons, electric shocks, atoms and molecules. Only a minority of the students has these interests, but it is this minority who appreciates school science and who chooses to study science at upper secondary school. The factor analysis also reveals large differences between genders and furthermore, that the students’ own interests govern their choice of study programme at upper secondary school.

  20. (In)security factor atomic bomb. An analysis of the crisis with the Iranian nuclear program

    International Nuclear Information System (INIS)

    Bock, Andreas

    2012-04-01

    Iran is a rational actor in the international politics that decides on the basis of the perception of threat. Iran's security situation is comparable with that of Israel with the rational consequence to rely on the atomic program with respect to deterrence and self-defense. The solution of the Iran crisis is basically dependent on a change of the perception of threat. A military act against the Iranian nuclear facilities would be counterproductive, would only slowing down the program but not prevent further activities. In fact a military act would enhance the perception of threat. For the analysis of the Iran crises the author used the Cuba crisis as blueprint, were mislead perceptions were responsible for the escalation.

  1. Rearranged anaplastic lymphoma kinase (ALK) gene found for the first time in adult-onset papillary thyroid cancer cases among atomic bomb survivors

    Energy Technology Data Exchange (ETDEWEB)

    Hamatani, K.; Mukai, M.; Takahashi, K.; Nakachi, K.; Kusunoki, Y. [Radiobiology/Molecular Epidemiology, Radiation Effects Research Foundation, Hiroshima (Japan); Hayashi, Y. [Geriatric Health Service Facility Hidamari, Hiroshima (Japan)

    2012-07-01

    Full text of the publication follows: Thyroid cancer is one of the malignancies most strongly associated with ionizing radiation in humans. Epidemiology studies of atomic bomb (A-bomb) survivors have indicated that excess relative risk of papillary thyroid cancer per Gy was remarkably high in the survivors. We therefore aim to clarify mechanisms linking A-bomb radiation exposure and development of papillary thyroid cancer. Toward this end, we intend to clarify characteristics of gene alterations occurring in radiation-associated adult-onset papillary thyroid cancer from the Life Span Study cohort of A-bomb survivors. We have thus far found that with increased radiation dose, papillary thyroid cancer cases with chromosomal rearrangements (mainly RET/PTC rearrangements) significantly increased and papillary thyroid cancer cases with point mutations (mainly BRAF-V600E) significantly decreased. Papillary thyroid cancer cases with non-detected gene alterations that carried no mutations in RET, NTRK1, BRAF or RAS genes tended to increase with increased radiation dose. In addition, we found that relative frequency of these papillary thyroid cancer cases significantly decreased with time elapsed since exposure. Through analysis of papillary thyroid cancer cases with non-detected gene alterations, we recently discovered a new type of rearrangement for the first time in papillary thyroid cancer, i.e., rearranged anaplastic lymphoma kinase (ALK) gene, although identification of any partner gene(s) is needed. Specifically, rearrangement of ALK was found in 10 of 19 exposed papillary thyroid cancer cases with non-detected gene alterations but not in any of the six non-exposed papillary thyroid cancer cases. Furthermore, papillary thyroid cancer with ALK rearrangement was frequently found in the cases with high radiation dose or with short time elapsed since A-bomb exposure. These results suggest that chromosomal rearrangement, typically of RET and ALK, may play an important

  2. Rearranged anaplastic lymphoma kinase (ALK) gene found for the first time in adult-onset papillary thyroid cancer cases among atomic bomb survivors

    International Nuclear Information System (INIS)

    Hamatani, K.; Mukai, M.; Takahashi, K.; Nakachi, K.; Kusunoki, Y.; Hayashi, Y.

    2012-01-01

    Full text of the publication follows: Thyroid cancer is one of the malignancies most strongly associated with ionizing radiation in humans. Epidemiology studies of atomic bomb (A-bomb) survivors have indicated that excess relative risk of papillary thyroid cancer per Gy was remarkably high in the survivors. We therefore aim to clarify mechanisms linking A-bomb radiation exposure and development of papillary thyroid cancer. Toward this end, we intend to clarify characteristics of gene alterations occurring in radiation-associated adult-onset papillary thyroid cancer from the Life Span Study cohort of A-bomb survivors. We have thus far found that with increased radiation dose, papillary thyroid cancer cases with chromosomal rearrangements (mainly RET/PTC rearrangements) significantly increased and papillary thyroid cancer cases with point mutations (mainly BRAF-V600E) significantly decreased. Papillary thyroid cancer cases with non-detected gene alterations that carried no mutations in RET, NTRK1, BRAF or RAS genes tended to increase with increased radiation dose. In addition, we found that relative frequency of these papillary thyroid cancer cases significantly decreased with time elapsed since exposure. Through analysis of papillary thyroid cancer cases with non-detected gene alterations, we recently discovered a new type of rearrangement for the first time in papillary thyroid cancer, i.e., rearranged anaplastic lymphoma kinase (ALK) gene, although identification of any partner gene(s) is needed. Specifically, rearrangement of ALK was found in 10 of 19 exposed papillary thyroid cancer cases with non-detected gene alterations but not in any of the six non-exposed papillary thyroid cancer cases. Furthermore, papillary thyroid cancer with ALK rearrangement was frequently found in the cases with high radiation dose or with short time elapsed since A-bomb exposure. These results suggest that chromosomal rearrangement, typically of RET and ALK, may play an important

  3. Report of a workshop on the application of molecular genetics to the study of mutation in the children of atomic-bomb survivors

    International Nuclear Information System (INIS)

    1993-09-01

    A workshop, entitled 'application of molecular genetics to the study of mutation in the children of atomic-bomb survivors,' was held on November 12-14, 1991, which was presided over by Mortimer Mendelsohn and Toshiyuki Kumatori, co-chairmen of the RERF Scientific Council. The purpose of this workshop was to evaluate the status of the emerging DNA-oriented techniques for the study of mutation and to discuss possible developments that would bear upon the program. Although specific genetic follow-up studies of children of A-bomb survivors were addressed, it was clear to the participants that their discussions had much-wider implications -- most notably, the Chernobyl accidents of 1986. This report summarizes the contents of the lively 2.5-day meeting. A complete list of the invited participants is shown in the Appendix. (N.K.) 79 refs

  4. Dose-responses for mortality from cerebrovascular and heart diseases in atomic bomb survivors: 1950-2003.

    Science.gov (United States)

    Schöllnberger, Helmut; Eidemüller, Markus; Cullings, Harry M; Simonetto, Cristoforo; Neff, Frauke; Kaiser, Jan Christian

    2018-03-01

    The scientific community faces important discussions on the validity of the linear no-threshold (LNT) model for radiation-associated cardiovascular diseases at low and moderate doses. In the present study, mortalities from cerebrovascular diseases (CeVD) and heart diseases from the latest data on atomic bomb survivors were analyzed. The analysis was performed with several radio-biologically motivated linear and nonlinear dose-response models. For each detrimental health outcome one set of models was identified that all fitted the data about equally well. This set was used for multi-model inference (MMI), a statistical method of superposing different models to allow risk estimates to be based on several plausible dose-response models rather than just relying on a single model of choice. MMI provides a more accurate determination of the dose response and a more comprehensive characterization of uncertainties. It was found that for CeVD, the dose-response curve from MMI is located below the linear no-threshold model at low and medium doses (0-1.4 Gy). At higher doses MMI predicts a higher risk compared to the LNT model. A sublinear dose-response was also found for heart diseases (0-3 Gy). The analyses provide no conclusive answer to the question whether there is a radiation risk below 0.75 Gy for CeVD and 2.6 Gy for heart diseases. MMI suggests that the dose-response curves for CeVD and heart diseases in the Lifespan Study are sublinear at low and moderate doses. This has relevance for radiotherapy treatment planning and for international radiation protection practices in general.

  5. Dose-responses from multi-model inference for the non-cancer disease mortality of atomic bomb survivors.

    Science.gov (United States)

    Schöllnberger, H; Kaiser, J C; Jacob, P; Walsh, L

    2012-05-01

    The non-cancer mortality data for cerebrovascular disease (CVD) and cardiovascular diseases from Report 13 on the atomic bomb survivors published by the Radiation Effects Research Foundation were analysed to investigate the dose-response for the influence of radiation on these detrimental health effects. Various parametric and categorical models (such as linear-no-threshold (LNT) and a number of threshold and step models) were analysed with a statistical selection protocol that rated the model description of the data. Instead of applying the usual approach of identifying one preferred model for each data set, a set of plausible models was applied, and a sub-set of non-nested models was identified that all fitted the data about equally well. Subsequently, this sub-set of non-nested models was used to perform multi-model inference (MMI), an innovative method of mathematically combining different models to allow risk estimates to be based on several plausible dose-response models rather than just relying on a single model of choice. This procedure thereby produces more reliable risk estimates based on a more comprehensive appraisal of model uncertainties. For CVD, MMI yielded a weak dose-response (with a risk estimate of about one-third of the LNT model) below a step at 0.6 Gy and a stronger dose-response at higher doses. The calculated risk estimates are consistent with zero risk below this threshold-dose. For mortalities related to cardiovascular diseases, an LNT-type dose-response was found with risk estimates consistent with zero risk below 2.2 Gy based on 90% confidence intervals. The MMI approach described here resolves a dilemma in practical radiation protection when one is forced to select between models with profoundly different dose-responses for risk estimates.

  6. Dose-responses from multi-model inference for the non-cancer disease mortality of atomic bomb survivors

    Energy Technology Data Exchange (ETDEWEB)

    Schoellnberger, H.; Kaiser, J.C.; Jacob, P. [Institute of Radiation Protection, Helmholtz Zentrum Muenchen, Department of Radiation Sciences, Neuherberg (Germany); Walsh, L. [BfS-Federal Office for Radiation Protection, Neuherberg (Germany)

    2012-05-15

    The non-cancer mortality data for cerebrovascular disease (CVD) and cardiovascular diseases from Report 13 on the atomic bomb survivors published by the Radiation Effects Research Foundation were analysed to investigate the dose-response for the influence of radiation on these detrimental health effects. Various parametric and categorical models (such as linear-no-threshold (LNT) and a number of threshold and step models) were analysed with a statistical selection protocol that rated the model description of the data. Instead of applying the usual approach of identifying one preferred model for each data set, a set of plausible models was applied, and a sub-set of non-nested models was identified that all fitted the data about equally well. Subsequently, this sub-set of non-nested models was used to perform multi-model inference (MMI), an innovative method of mathematically combining different models to allow risk estimates to be based on several plausible dose-response models rather than just relying on a single model of choice. This procedure thereby produces more reliable risk estimates based on a more comprehensive appraisal of model uncertainties. For CVD, MMI yielded a weak dose-response (with a risk estimate of about one-third of the LNT model) below a step at 0.6 Gy and a stronger dose-response at higher doses. The calculated risk estimates are consistent with zero risk below this threshold-dose. For mortalities related to cardiovascular diseases, an LNT-type dose-response was found with risk estimates consistent with zero risk below 2.2 Gy based on 90% confidence intervals. The MMI approach described here resolves a dilemma in practical radiation protection when one is forced to select between models with profoundly different dose-responses for risk estimates. (orig.)

  7. Lack of effects of atomic bomb radiation on genetic instability of tandem-repetitive elements in human germ cells

    International Nuclear Information System (INIS)

    Kodaira, Mieko; Satoh, Chiyoko; Hiyama, Keiko

    1995-01-01

    In a pilot study to detect the potential effects of atomic bomb radiation on germ-line instability, we screened 64 children from 50 exposed families and 60 from 50 control families for mutations at six minisatellite loci by using Southern blot analysis with Pc-1, λTM-18, ChdTC-15, pλg3, λMS-1, and CEB-1 probes. In the exposed families, one or both parents received a radiation dose >0.01 Sv. Among the 64 children, only one child had parents who were both exposed. Thus, of a total of 128 gametes that produced the 64 children, 65 gametes were derived from exposed parents and 63 were from unexposed parents, the latter being included in a group of 183 unexposed gametes used for calculating mutation rates. The average parental gonadal dose for the 65 gametes was 1.9 Sv. We detected a total of 28 mutations at the pλg3, λMS-1, and CEB-1 loci, but no mutations at the Pc-1, λTM-18, and ChdTC-15 loci. We detected 6 mutations in 390 alleles of the 65 exposed gametes and 22 mutations in 1098 alleles of the 183 gametes from the unexposed parents. The mean mutation rate per locus per gamete in these six minisatellite loci was 1.5% in the exposed parents and 2.0% in the unexposed parents. We observed no significant difference in mutation rates in the children of the exposed and the unexposed parents (P = .37, Fisher's exact probability test). 38 refs., 1 fig., 5 tabs

  8. Report on the results of the seventh medical examination of atomic bomb survivors resident in North America

    International Nuclear Information System (INIS)

    Ito, Chikako; Kodama, Kazunori; Sasaki, Hideo; Ishibashi, Shinzo; Dote, Keigo; Watanabe, Tadaaki; Hirata, Katsumi; Sugimoto, Sumio.

    1990-01-01

    During a one-month period from June 13 through July 13, 1989, the seventh medical examination was conducted at five cities, including San Francisco, Los Angeles, Seattle, Wailuku and Honolulu, for A-bomb survivors residents in North America. Nine hundred and eighteen A-bomb survivors, including 21 living in Canada, were confirmed, consisting of 234 men and 684 women as of the end of July 1989. The number was increased by 167, compared with that as of the end of July 1987. During the past three years, there were 40 deaths; and 878 A-bomb survivors (223 men and 655 women) are still alive. Ninety percent of the survivors came from Hiroshima. U.S. nationality was seen in 61% and Japanese nationality with permanent U.S. residency rights was seen in 32%. The majority (39%) of the A-bomb survivors were in their fifties, with an average age of 59.4 years. The survivors were residing in 26 states in the USA and in 3 provinces in Canada. The acquisition rate of the A-bomb survivors' health handbook was 52%. Four hundred and six A-bomb survivors participated in the medical examination, including one male and 8 female children born to A-bomb survivors. Questionnaire survey revealed a history of surgical resection for cancer in 21 survivors. Subjective symptoms included complete exhaustion or fatigue, heat intolerance, loss of vigor, and numbness of the body. Overall evaluation revealed the necessity of medical treatment or observation in 71%. This was independent of exposure status. Hypertension was the most common (27%), followed by obesity, hyperlipidemia, heart disease, and diabetes mellitus. Malignant tumors were seen in 9 survivors, consisting of 3 with breast cancer, 2 with colorectal cancer, and single survivors with lung cancer, Hodgkin's disease, cervical cancer, or hepatoma. Only 29% of them have had finantial guarantee for their health management according to the Japanese law. (N.K.)

  9. Carcinogenesis model analysis for breast cancer incidence among atomic bomb survivors and the implications for cancer risk estimate for radiological protection

    International Nuclear Information System (INIS)

    Kai, Michiaki; Kusama, Tomoko

    2000-01-01

    Breast cancer incidence is the highest risk due to radiation among atomic bomb survivors. The excess relative risk of the early-onset breast cancer seems to be remarkably high for the youngest age-at-exposure groups. The cancer risk estimate of breast cancer is a current issue in radiological protection. We used a two-stage stochastic model for carcinogenesis to analyze the breast cancer incidence among atomic bomb survivors (Kai, et al. Radiat. Res. 1997). Our purpose is to examine the dependence of radiation risk on age at exposure using the two-stage model and how to transfer it to other populations for radiological protection. We fitted the model assuming that radiation acts as an initiator and that the rate of radiation-induced mutation and background initiation mutation leading to baseline cancer are additive. We took two age-dependence, not attained age but age at exposure, of the spontaneous process into account. First, age-dependence of spontaneous initiation was expressed by a linear model. We also modeled the age-dependence of spontaneous net growth rate of initiated cells by a linear function. As far as radiation-induced initiation is concerned, we took a stepwise function other than a liner function into account. The analysis did not show that the radiation mutation for the youngest age-at-exposure groups below age 10 was higher than for the older groups. Furthermore, the incidence of female breast cancer in Japan is increasing and the birth cohort effect can be observed in atomic bomb survivors. Our model assumed that an acute exposure to atomic radiation can only initiate cancers and do not influence other stages of carcinogenesis, whereas spontaneous initiation and promotion are age-dependent to consider birth cohort effects. When these cohort effects are properly accounted for, the shape of the age-specific incidence curve in Japan is remarkably similar to the age-specific incidence in western populations (shown in figure). Recently Little and

  10. Potential influence of new doses of A-bomb after re-evaluation of epidemiological research

    International Nuclear Information System (INIS)

    Maruyama, T.

    1983-01-01

    Since the peaceful use of atomic energy appears essential for future human existence, we must provide risk estimates from low-dose exposures to human beings. The largest body of human data has been derived from the studies of atomic bomb survivors in Hiroshima and Nagasaki. Recently, it was proposed by an Oak Ridge National Laboratory group that the current free-in-air doses of atomic bombs are significantly different from the doses recalculated on the basis of the new output spectra of neutrons and gamma rays from the atomic bombs which were declassified by the US Department of Energy in 1976. A joint commission on dose re-evaluation of the United States of America and Japan was established in 1981 to pursue the dose reassessment programme between US and Japanese research groups and to decide an agreed best estimate of organ or tissue doses in survivors as soon as possible. The paper reviews the physical concepts of the re-evaluation of atomic bomb doses and discusses the potential influence of new dosimetric parameters on the epidemiological studies of the atomic bomb survivors in future, although the re-assessment programme is still in progress. (author)

  11. Report on the results of the second medical examination of atomic bomb survivors resident in the South America

    International Nuclear Information System (INIS)

    Kamitsuna, Akimitsu; Monzen, Tetsuo; Oguma, Nobuo; Sakuma, Saburo; Takata, Yoshiki; Nakashima, Yoshiaki; Sakata, Morimitsu.

    1987-01-01

    In October 9 - 31, 1986, the second medical examination for A-bomb survivors was undertaken in Brazil, Argentina, Paraguay, Bolivia, and Peru. Among 173 recognized A-bomb survivors in the five countries, 126 (73 %) participated in the examination, consisting of 61 men and 65 women. Seventy-eight A-bomb survivors came from Hiroshima and 48 from Nagasaki. The average age was 55.6 +- 9.7 years for men and 56.5 +- 9.8 years for women. The acquisition rate of ''Survivor's Health Handbook'' was 34 %. Gastric cancer was observed in two survivors and cervical cancer in one survivor. Major subjective symptoms were: fatigue, sensation of paralysis, heat intolerance, decreased physical strength, and itching. None of the abnormal findings were observed in 33 %. The incidence of hypertension, obesity, cardiac disease, and liver disease was high. The incidence of hypercholesteremia and diabetes mellitus was lower than that in the USA. (Namekawa, K.)

  12. Report on the results of the tenth medical examination of atomic bomb survivors resident in North America

    International Nuclear Information System (INIS)

    Shibata, Jun; Ohta, Nobuhiro; Sasaki, Hideo

    1996-01-01

    The 10th medical examination of A-bomb survivors resident in North America was conducted from 6 June to 6 July 1995 in L.A., S.F., Seattle, Wailuku, and Honolulu. Since this is the 10th medical examination, results of the previous examination are summarized. With the exclusion of 55 whose death has been confirmed, the total registered number of A-bomb survivors resident in North America is 1,043. The examinees in the present examination amounted to 463 (48 of them are the children of A-bomb survivors), 26 of whom are newly registered survivors. The mean age of the examinees in 64 years. The proportion of those having US nationality gradually increased and reached 62% at the time of the 10th examination, while that of those who have Japanese nationality and permanent US residency rights decreased to 30%. When the examination program was initiated, A-bomb survivors resident in 15 states of the US, but now, in Canada and 31 states of the US. About 90% of these survivors reside along the west coast of the US including Hawaii. The number of holders of A-bomb survivor's health handbook has increased year after year, reaching 612. When the holders in North-America visit Japan for medical treatment, they are treated similarly with their counterparts in Japan. The major subjective symptoms are complete exhaustion or fatigue, heat intolerance, loss of vigor, and numbness or tingling. The prevalence of obesity, hypertension, and diabetes mellitus and the proportion of abnormal ECG findings has been increasing with the age. The prevalence of hypercholesterolemia was high and that of low HDL cholesterolemia was low. A significant difference was observed between the A-bomb survivors in Hiroshima and North America. Hypertension, hyperlipidemia, obesity, ischemic heart disease, and diabetes mellitus were observed mainly. Diseased of specific places were not observed. (H.O.)

  13. Leukemia incidence among individuals exposed in utero, children of atomic bomb survivors, and their controls; Hiroshima and Nagasaki, 1945-79

    International Nuclear Information System (INIS)

    Ishimaru, Toranosuke; Ichimaru, Michito; Mikami, Motoko.

    1982-03-01

    The incidence of leukemia has been analyzed in relation to the fetal dose of individuals exposed in utero, and the parental gonadal dose of individuals born to atomic bomb survivors and controls in the two fixed RERF cohorts. Among 3,636 in utero exposed children and controls, 3 leukemia cases have been identified through 1979. No excess risk of leukemia for in utero exposed children is apparent. For children born to exposed parents and controls, 36 leukemia cases have been identified in the years 1946-79 among 50,689 study subjects where the parental gonadal dose is available. Again, no excess risk of leukemia exists. (author)

  14. The Atomic Papers: A citizen's guide to selected books and articles on the bomb, the arms race, nuclear power, the peace movement, and related issues

    International Nuclear Information System (INIS)

    Burns, G.

    1984-01-01

    The Atomic Papers annotates over 800 books published since 1945 and approximately 300 periodical articles since 1980 on every facet of the nuclear dilemma: the development and effects of the bomb, the arms race, nuclear proliferation, and the peace movement. Work on both sides of the nuclear power controversy also receives substantial attention. All references are to English-language material, and nearly half are to work published since 1980. The concluding chapter, ''The Art of Fission,'' describes over one hundred novels and stories with nuclear themes published since 1945--and, in a few cases, before that date

  15. Statement by IAEA Director General on the 60th anniversary of the atomic bombing of Hiroshima and Nagasaki

    International Nuclear Information System (INIS)

    2005-01-01

    Full text: No one who has seen the victims, the film footage or photographs of the aftermath of the destruction of Hiroshima and Nagasaki at the end of World War II can fail to be horrified by the devastation that was wrought by the use of nuclear weapons. To date, Hiroshima and Nagasaki thankfully remain the only instances in which nuclear weapons have been used, and while it is difficult to speak of any good coming out of such ruin, it has always been hoped that the atomic bombing of Hiroshima and Nagasaki stand as constant reminders of why preventing the further use and proliferation of such weapons - and why nuclear disarmament leading to a nuclear-weapon-free world - is of utmost importance for the survival of humankind and planet Earth. The International Atomic Energy Agency born out of President Eisenhower's 'Atoms for Peace' vision, came at a time when the horrifying consequences and images of Hiroshima and Nagasaki were still fresh. Through its safeguards and verification system in support of the 1968 Treaty on the Non-Proliferation of Nuclear Weapons (NPT) and other similar non-proliferation agreements, the IAEA has done a great deal of work to help stem the tide of nuclear proliferation, while ensuring that the benefits of the peaceful uses of nuclear energy are made available to all those who want them. While the Agency can effectively verify compliance with non-proliferation undertakings, the value of these efforts can be better realized if they are reinforced by all other components of the nuclear non-proliferation and arms control regime, and accompanied by the political will and dialogue among concerned States to address underlying issues of security and confidence building with a view to achieving a system of collective security that no longer relies on nuclear weapons. A world without nuclear weapons remains a far-off goal and the world continues to be burdened with nearly thirty thousand nuclear warheads. The Comprehensive Nuclear-Test-Ban Treaty

  16. Serum TSH, thyroglobulin, and thyroid disorders in atomic bomb survivors exposed in youth: a study 30 years after exposure

    International Nuclear Information System (INIS)

    Morimoto, Isao; Yoshimoto, Yasuhiko; Sato, Kenshi; Hamilton, H.B.; Kawamoto, Sadahisa; Izumi, Motomori; Nagataki, Shigenobu.

    1986-08-01

    A study of individuals in Hiroshima and Nagasaki who were under 20 years of age at the time of atomic bomb exposure and who had been exposed to 100+ rad was conducted to determine the frequency of thyroid disorders as well as the levels of serum thyroid stimulating hormone (TSH), antithyroglobulin antibody, and thyroglobulin (TG), 30 years after exposure. Thyroid disorders were detected in 56 of the 477 subjects of the 100+ rad exposed group and in 39 of the 501 subjects of the 0 rad exposed group, the prevalence being significantly higher in the former group (X 2 = 3.872, P = 0.049). This increased prevalence of thyroid disorders in the 100+ rad exposed group was due to the increased occurrence of thyroid cancer and nontoxic uninodular goiter. Thyroid cancer was found in eight exposed individuals, all of whom belonged to the 100+ rad group; statistically, the prevalence was significantly higher (X 2 = 7.919, P = 0.005). Nontoxic uninodular goiter was observed in 13 cases of the 100+ rad exposed group and 3 cases of the 0 rad exposed group, the prevalence in the 100+ rad exposed group being significantly higher (X 2 = 6.584, P = 0.010). In these cases no increase of serum TSH or TG levels was observed. Mean serum TSH levels in individuals without thyroid disorders were 1.64 ± 1.89 μU/ml (n = 421) in the 100+ rad exposed group and 1.54 ± 1.86 μU/ml (n = 462) in the 0 rad exposed group. Mean serum TG levels were 13.49 ± 13.88 ng/ml (n = 421) in the 100+ rad exposed group and 14.76 ± 15.69 ng/ml (n = 462) in the 0 rad exposed group. Thus, these differences between the two groups were not significant. Also, no significant differences were observed between the 100+ rad and 0 rad exposed groups in the mean serum TSH and TG levels of the subjects who had thyroid diseases but had not been treated for the diseases, and the subjects who had no thyroid diseases. (J.P.N.)

  17. Lung, Laryngeal and Other Respiratory Cancer Incidence among Japanese Atomic Bomb Survivors: An Updated Analysis from 1958 through 2009.

    Science.gov (United States)

    Cahoon, Elizabeth K; Preston, Dale L; Pierce, Donald A; Grant, Eric; Brenner, Alina V; Mabuchi, Kiyohiko; Utada, Mai; Ozasa, Kotaro

    2017-05-01

    The Life Span Study (LSS) of Japanese atomic bomb survivors is comprised of a large, population-based cohort offering one of the best opportunities to study the relationship between exposure to radiation and incidence of respiratory cancers. Risks of lung, laryngeal and other cancers of the respiratory system were evaluated among 105,444 LSS subjects followed from 1958 to 2009. During this period, we identified 2,446 lung, 180 laryngeal and 115 other respiratory (trachea, mediastinum and other ill-defined sites) first primary incident cancer cases. Ten additional years of follow-up, improved radiation dose estimates, revised smoking data, and updated migration information were used to investigate the joint effects of radiation and smoking using Poisson regression methods. For nonsmokers, the sex-averaged excess relative risk per Gy (ERR/Gy) for lung cancer (at age 70 after radiation exposure at age 30) was estimated as 0.81 (95% CI: 0.51, 1.18) with a female-to-male ratio of 2.83. There was no evidence of curvature in the radiation dose-response relationship overall or by sex. Lung cancer risks increased with pack-years of smoking and decreased with time since quitting smoking at any level of radiation exposure. Similar to the previously reported study, which followed cohort members through 1999, the ERR/Gy for lung cancer was significantly higher for low-to-moderate smokers than for heavy smokers, with little evidence of any radiation-associated excess risk in heavy smokers. Of 2,446 lung cancer cases, 113 (5%) could be attributed to radiation exposure. Of the 1,165 lung cancer cases occurring among smokers, 886 (76%) could be attributed to smoking. While there was little evidence of a radiation effect for laryngeal cancer, a nonsignificantly elevated risk of other respiratory cancers was observed. However, significant smoking effects were observed for both laryngeal (ERR per 50 pack-years = 23.57; 95% CI: 8.44, 71.05) and other respiratory cancers (ERR per 50

  18. Incidence of skin cancer in Nagasaki atomic bomb survivors based on DS86 dosimetry system, 1958-1985

    Energy Technology Data Exchange (ETDEWEB)

    Sadamori, Naoki (Nagasaki Univ. (Japan). School of Medicine); Otake, Masanori; Honda, Takeo

    1992-03-01

    The incidence of skin cancer during the period 1958-1985 was examined in the population registered in the life span study extension (LSSE) and the adult health study (AHS). Among 25,942 A-bomb survivors in whom DS86 was available, skin cancer was confirmed in 47 A-bomb survivors. These A-bomb survivors consisted of 24 males and 23 females. According to DS86 dosimetry system, ten A-bomb survivors had been exposed to 0.50 Gy or more. The most common histology was basal cell epithelioma (n=25), followed by malignant melanoma (n=4) and basosquamous cell carcinoma and sweat gland carcinoma (one each). In the group of 0.50 Gy or more, the incidence of occurrence of skin cancer was 20.8/100,000 population per year (PY) for the LSSE population and 22.8/100,000 PY for the AHS population. In the group of 0.01-0.49 Gy, it was 6.8/100,000 PY for the LSSE population and 12.8/100,000 PY for the AHS population. It was significantly associated with higher exposure doses. The dose-response relationship was linear. (N.K.).

  19. Mental disorders in 37 cases of 'Hibakusya' 40 years after exposure to the atomic bomb

    Energy Technology Data Exchange (ETDEWEB)

    Nonaka, Takeshi; Tohyama, Teruhiko; Nakazawa, Masao; Ando, Ichiro; Hayashi, Hideki; Miura, Hirofumi

    1987-07-01

    In 1985, 40 years after the bombing, 37 (8 %) of a total of 814 A-bomb survivors living in Tokyo visited the Department of Neuro-Psychiatry. This is an analysis of these A-bomb survivors suffering from mental disorders. There were 11 men and 26 women. They ranged in age from 45 to 87 years with a median of 61. Eighteen survivors (55 %) were exposed within 2,000 m from ground zero, and 21 (66 %) presented with acute radiation symptoms. According to the classification of DSM-III, features of mental disorders fell into five types: (1) organic psychotic conditions (n = 7), (2) endogenous psychotic conditions (n = 14), (3) delution (n = 3), (4) anxiety somatization (n = 11), and (5) personality disorder (n = 2). Psychotic conditions characterized by mixed atypical symptoms, variable clinical features during the process, and undefined somatic symptoms were noticeable in this series. This is in contrast to the previous reports dealing with neurasthenic A-bomb survivors. The etiology of psychotic conditions must await further study. (Namekawa, K.).

  20. Relative risks of radiation-associated cancer: comparison of second cancer in therapeutically irradiated populations with the Japanese atomic bomb survivors

    International Nuclear Information System (INIS)

    Little, M.P.; Muirhead, C.R.; Haylock, R.G.E.; Thomas, J.M.

    1999-01-01

    In this paper the radiation-associated relative risks of second primary cancer incidence in groups treated for first primary cancer by radiotherapy are compared with radiation-associated relative risk estimates in the Japanese atomic bomb survivor cancer incidence data. For four cancer sites, namely lung cancer, bone cancer, ovarian cancer and leukaemia, the relative risks in the comparable (age at exposure, time since exposure, sex matched) subsets of the Japanese data are significantly greater than those in the majority of second cancer studies. Even when the differences between the relative risks in the Japanese atomic bomb survivors and the medical series do not approach conventional levels of statistical significance, relative risks tend to be higher in the Japanese data than in the second cancer studies. At least for leukaemia, the discrepancy between the Japanese and second cancer risks can be largely explained by cell- sterilisation effects. There are few indications of modification of radiation-associated second cancer relative risk among those treated with adjuvant chemotherapy, nor are there strong indications of modification of radiation- associated relative risk by heritable genetic factors. If anything, there is evidence that second cancer relative excess risks are lower among those patients with cancer-prone disorders than among non-susceptible patients. However, the higher underlying cancer risk in some of these medically exposed populations should also be considered, in particular for those with cancer-prone conditions, so that the absolute excess risk is sometimes higher than in the Japanese data. (orig.)

  1. Action taken by three humans, an American physicist in the bomber, two Japanese with radiation poisoning in Hiroshima and Nagasaki when the atomic bombs were exploded

    International Nuclear Information System (INIS)

    Fukui, Shuji

    2007-01-01

    Luis W. Alvarez of the Lawrence Berkeley National Laboratory (LBNL), University of California, USA, won the Nobel Prize for physics of elementary particle in 1968. He was very famous physicist and concerned the World War II in some ways. He joined the radar research development at MIT Radiation Lab. in 1940, then he developed the magnetron and the ground-controlled approach (GCA) for blind landing of planes. Afterwards he joined the Manhattan Project to fabricate the atomic bombs. His career connecting to those is introduced partly based on his autobiography. In addition, introduced are two reports by two Japanese, the personal experience of Yoko Ota with radiation poisoning in Hiroshima, and the action of Takashi Nagai who assisted the victims of radiation poisoning in Nagasaki even if he had radiation poisoning himself, as well as a letter from Luis W. Alvarez to Ryokichi Sagane, which was put in the tube of atomic bomb energy measuring instruments. Nightmares of the Hiroshima view are also introduced. (S.Y.)

  2. Long-term radiation-related health effects in a unique human population: lessons learned from the atomic bomb survivors of Hiroshima and Nagasaki.

    Science.gov (United States)

    Douple, Evan B; Mabuchi, Kiyohiko; Cullings, Harry M; Preston, Dale L; Kodama, Kazunori; Shimizu, Yukiko; Fujiwara, Saeko; Shore, Roy E

    2011-03-01

    For 63 years scientists in the Atomic Bomb Casualty Commission and its successor, the Radiation Effects Research Foundation, have been assessing the long-term health effects in the survivors of the atomic bombings of Hiroshima and Nagasaki and in their children. The identification and follow-up of a large population (approximately a total of 200,000, of whom more than 40% are alive today) that includes a broad range of ages and radiation exposure doses, and healthy representatives of both sexes; establishment of well-defined cohorts whose members have been studied longitudinally, including some with biennial health examinations and a high survivor-participation rate; and careful reconstructions of individual radiation doses have resulted in reliable excess relative risk estimates for radiation-related health effects, including cancer and noncancer effects in humans, for the benefit of the survivors and for all humankind. This article reviews those risk estimates and summarizes what has been learned from this historic and unique study.

  3. The human sex odds at birth after the atmospheric atomic bomb tests, after Chernobyl, and in the vicinity of nuclear facilities.

    Science.gov (United States)

    Scherb, Hagen; Voigt, Kristina

    2011-06-01

    Ever since the discovery of the mutagenic properties of ionizing radiation, the possibility of birth sex odds shifts in exposed human populations was considered in the scientific community. Positive evidence, however weak, was obtained after the atomic bombing of Japan. We previously investigated trends in the sex odds before and after the Chernobyl Nuclear Power Plant accident. In a pilot study, combined data from the Czech Republic, Denmark, Finland, Germany, Hungary, Norway, Poland, and Sweden between 1982 and 1992 showed a downward trend in the sex odds and a significant jump in 1987, the year immediately after Chernobyl. Moreover, a significant positive association of the sex odds between 1986 and 1991 with Chernobyl fallout at the district level in Germany was observed. Both of these findings, temporality (effect after exposure) and dose response association, yield evidence of causality. The primary aim of this study was to investigate longer time periods (1950-2007) in all of Europe and in the USA with emphasis on the global atmospheric atomic bomb test fallout and on the Chernobyl accident. To obtain further evidence, we also analyze sex odds data near nuclear facilities in Germany and Switzerland. DATA AND STATISTICAL METHODS: National gender-specific annual live births data for 39 European countries from 1975 to 2007 were compiled using the pertinent internet data bases provided by the World Health Organization, United Nations, Council of Europe, and EUROSTAT. For a synoptic re-analysis of the period 1950 to 1990, published data from the USA and from a predominantly western and less Chernobyl-exposed part of Europe were studied additionally. To assess spatial, temporal, as well as spatial-temporal trends in the sex odds and to investigate possible changes in those trends after the atomic bomb tests, after Chernobyl, and in the vicinity of nuclear facilities, we applied ordinary linear logistic regression. Region-specific and eventually changing spatial

  4. Neutron relative biological effectiveness for solid cancer incidence in the Japanese A-bomb survivors: an analysis considering the degree of independent effects from γ-ray and neutron absorbed doses with hierarchical partitioning.

    Science.gov (United States)

    Walsh, Linda

    2013-03-01

    It has generally been assumed that the neutron and γ-ray absorbed doses in the data from the life span study (LSS) of the Japanese A-bomb survivors are too highly correlated for an independent separation of the all solid cancer risks due to neutrons and due to γ-rays. However, with the release of the most recent data for all solid cancer incidence and the increased statistical power over previous datasets, it is instructive to consider alternatives to the usual approaches. Simple excess relative risk (ERR) models for radiation-induced solid cancer incidence fitted to the LSS epidemiological data have been applied with neutron and γ-ray absorbed doses as separate explanatory covariables. A simple evaluation of the degree of independent effects from γ-ray and neutron absorbed doses on the all solid cancer risk with the hierarchical partitioning (HP) technique is presented here. The degree of multi-collinearity between the γ-ray and neutron absorbed doses has also been considered. The results show that, whereas the partial correlation between the neutron and γ-ray colon absorbed doses may be considered to be high at 0.74, this value is just below the level beyond which remedial action, such as adding the doses together, is usually recommended. The resulting variance inflation factor is 2.2. Applying HP indicates that just under half of the drop in deviance resulting from adding the γ-ray and neutron absorbed doses to the baseline risk model comes from the joint effects of the neutrons and γ-rays-leaving a substantial proportion of this deviance drop accounted for by individual effects of the neutrons and γ-rays. The average ERR/Gy γ-ray absorbed dose and the ERR/Gy neutron absorbed dose that have been obtained here directly for the first time, agree well with previous indirect estimates. The average relative biological effectiveness (RBE) of neutrons relative to γ-rays, calculated directly from fit parameters to the all solid cancer ERR model with both

  5. Report on the results of the fifteenth medical examination of atomic bomb survivors resident in North America

    International Nuclear Information System (INIS)

    Kambe, Masayuki; Matsumura, Makoto; Suyama, Akihiko

    2006-01-01

    The fifteenth medical examination of A-bomb survivors resident in North America was carried out from May 11th through May 25th and from June 15th through June 29th, 2005, in the cities of Los Angeles, San Francisco, Seattle, and Honolulu. The total number of those who underwent the fifteenth medical examination was 435, 68 of whom were second-generation A-bomb survivors. As the survivors in North America are advancing in age, the average age of the examinees was 73.1 years. The examination items included an interview, clinical and physical examinations, electrocardiography (E.C.G.), and blood, urine, and stool tests. The review of the medical history showed that hypertension was the most frequent in the survivors examined, with the prevalence of 51.8%. Previous history of malignant tumors was observed in 19.6% of the survivors examined, with major sites being the mammary gland, uterus, colon, and prostate. As a result of the blood test, 12.8% of the survivors examined were diagnosed as diabetic, and hypercholesterolemia was found in 26.2% of the survivors examined. Latent hypothyroidism was found in 16.9% of the survivors examined. Among the examinees of A-bomb survivors, statistically significant associations with exposure status were not found in any disease or examination finding. A report providing the results of the medical examination and the necessity of undergoing closer examination and receiving medical treatment, if any, was mailed to each examinee. (author)

  6. Report on the results of the eighteenth medical examination of atomic bomb survivors resident in North America

    International Nuclear Information System (INIS)

    Usui, Shizuteru; Matsumura, Makoto; Yanagida, Jitsuro

    2012-01-01

    The eighteenth medical examination of A-bomb survivors resident in North America was carried out from June 15th through 29th and from July 13th through 27th, 2011, in the cities of Los Angeles, Honolulu, San Francisco, and Seattle. The total number of those who underwent the eighteenth medical examination was 378, 77 of whom were second-generation A-bomb survivors. As the survivors in North America are advancing in age, the average age of the examinees was 77.6 years. The examination items included an medical interview, clinical (including surgical and gynecological) examinations, physical measurement, electrocardiography (ECG), and hematology, blood biochemistry, urine, and fecal occult blood reaction tests, and cervical cancer screening. The review of the medical history showed that hypertension was the most frequent in the survivors examined, with the prevalence of about 60%. Previous history of malignant tumors was observed in about 18% of the survivors examined, with major cancer sites being the prostate, mammary gland, colon, and uterus. As a result of the blood biochemistry test, about 38% and 67% of the survivors examined were diagnosed with diabetes mellitus and/or impaired glucose tolerance (IGT) and dyslipidemia, respectively. Analyses of the A-bomb survivors who underwent this examination showed no statistically significant associations between exposure status and any disease or examination finding. A report providing the results of the medical examination and the necessity of undergoing closer examination, receiving medical treatment, and clinical follow-up, if any, was mailed to each examinee. (author)

  7. Report on the results of the seventeenth medical examination of atomic bomb survivors resident in North America

    International Nuclear Information System (INIS)

    Usui, Shizuteru; Matsumura, Makoto; Yanagida, Jitsuro

    2010-01-01

    The seventeenth medical examination of A-bomb survivors resident in North America was carried out from September 16th through 30th and from October 7th through 21st, 2009, in the cities of Los Angeles, Honolulu, San Francisco, and Seattle. The total number of those who underwent the seventeenth medical examination was 394, 71 of whom were second-generation A-bomb survivors. As the survivors in North America are advancing in age, the average age of the examinees was 76.3 years. The examination items included an interview, clinical (including surgical and gynecological) examinations and physical measurement, transcutaneous measurement of arterial oxygen saturation, electrocardiography (ECG), and hematology, blood biochemistry, urine, and fecal occult blood reaction test and cervical cancer screening. The review of the medical history showed that hypertension was the most frequent in the survivors examined, with the prevalence of 57.6%. Previous history of malignant tumors was observed in 23.2% of the survivors examined, with major cancer sites being the prostate, mammary gland, colon, and uterus. As a result of the blood biochemistry test, 24.8% of the survivors examined were diagnosed with impaired glucose tolerance (IGT). Abnormal total cholesterol levels and thyroid dysfunction were found in 51.9% and 23.0% of the survivors examined, respectively. Analyses of the A-bomb survivors who underwent this examination showed no statistically significant associations between distance from the hypocenter and any disease or examination finding. A report providing the results of the medical examination and the necessity of undergoing closer examination, receiving medical treatment, and clinical follow-up, if any, was mailed to each examinee. (author)

  8. Report on the results of the thirteenth medical examination of atomic bomb survivors resident in north america

    International Nuclear Information System (INIS)

    Yamamoto, Yasuji; Ohta, Michiya; Urabe, Takeshi

    2002-01-01

    The thirteenth medical examination of A-bomb survivors resident in North America was carried out from June 13th through June 27th and from July 12th through July 26th, 2001, in the cities of Los Angeles, San Francisco, Seattle, and Honolulu. The total number of those who underwent the thirteenth medical examination was 399, 53 of whom were second-generation A-bomb survivors. As the survivors in North America are advancing in age, the average age of the examinee was 69.5 years. The examination items included an interview, clinical and physical examinations, electrocardiography (E.C.G.), and blood, urine, and stool tests. The review of the medical history showed that hypertension was the most frequent in the survivors examined, with the prevalence of 39.3%. Previous history of malignant tumors was observed in 13.6% of the survivors examined, with major sites being the mammary gland, uterine, and colon. As a result of the blood test, 9.5% of the survivors examined were diagnosed as diabetic, and hypercholesterolemia was found in 32.1% of the survivors examined. Latent hypothyroidism was found in 18.5% of the survivors examined. No disease or examination finding showed a clear relation with exposure status. A report providing the results of the medical examination and necessity of undergoing closer examination and receiving medical treatment, if any, was mailed to each examinee. (author)

  9. Report on the results of the thirteenth medical examination of atomic bomb survivors resident in north america

    Energy Technology Data Exchange (ETDEWEB)

    Yamamoto, Yasuji; Ohta, Michiya [Hiroshima Prefectural Medical Association (Japan); Urabe, Takeshi [Hiroshima Prefectural Hospital (Japan)] [and others

    2002-05-01

    The thirteenth medical examination of A-bomb survivors resident in North America was carried out from June 13th through June 27th and from July 12th through July 26th, 2001, in the cities of Los Angeles, San Francisco, Seattle, and Honolulu. The total number of those who underwent the thirteenth medical examination was 399, 53 of whom were second-generation A-bomb survivors. As the survivors in North America are advancing in age, the average age of the examinee was 69.5 years. The examination items included an interview, clinical and physical examinations, electrocardiography (E.C.G.), and blood, urine, and stool tests. The review of the medical history showed that hypertension was the most frequent in the survivors examined, with the prevalence of 39.3%. Previous history of malignant tumors was observed in 13.6% of the survivors examined, with major sites being the mammary gland, uterine, and colon. As a result of the blood test, 9.5% of the survivors examined were diagnosed as diabetic, and hypercholesterolemia was found in 32.1% of the survivors examined. Latent hypothyroidism was found in 18.5% of the survivors examined. No disease or examination finding showed a clear relation with exposure status. A report providing the results of the medical examination and necessity of undergoing closer examination and receiving medical treatment, if any, was mailed to each examinee. (author)

  10. Radiation dose response estimation with emphasis on low dose range using restricted cubic splines: application to all solid cancer mortality data, 1950-2003, in atomic bomb survivors.

    Science.gov (United States)

    Nakashima, Eiji

    2015-07-01

    Using the all solid cancer mortality data set of the Life Span Study (LSS) cohort from 1950 to 2003 (LSS Report 14) data among atomic bomb survivors, excess relative risk (ERR) statistical analyses were performed using the second degree polynomial and the threshold and restricted cubic spline (RCS) dose response models. For the RCS models with 3 to 7 knots of equally spaced percentiles with margins in the dose range greater than 50 mGy, the dose response was assumed to be linear at less than 70 to 90 mGy. Due to the skewed dose distribution of atomic bomb survivors, the current knot system for the RCS analysis results in a detailed depiction of the dose response as less than approximately 0.5 Gy. The 6 knot RCS models for the all-solid cancer mortality dose response of the whole dose or less than 2 Gy were selected with the AIC model selection criterion and fit significantly better (p cubic spline in the lower and upper tails, and the best RCS model selected with AIC criterion was the usual RCS with L-constraints in both the lower and upper tails. The selected RCS had a linear dose-response model in the lower dose range (i.e., < 0.2-0.3 Gy) and was compatible with the linear no-threshold (LNT) model in this dose range. The proposed method is also useful in describing the dose response of a specific cancer or non-cancer disease incidence/mortality.

  11. Characteristics of colon cancer among atomic bomb exposure obtained from autopsy specimen at data and specimens center of atomic bomb disaster at Research Institute for Nuclear Medicine and Biology of Hiroshima University

    International Nuclear Information System (INIS)

    Ito, Akihiro; Kagawa, Naoki; Watanabe, Hiromitsu; Fukazawa, Kiichi; Hayakawa, Norihiko; Munaka, Masami

    1989-01-01

    Autopsy data of colon cancer from 135 A-bomb survivors (Group A) found during the period 1952-1981 were analyzed in terms of sex, age, site of occurrence, distance from the hypocenter, and histology. Control data were collected from 72 patients with surgery or biopsy proven colon cancer (Group B) found during the period 1983-1987. Patients consisted of 76 men and 59 women in Group A, and 44 men and 28 women in Group B. According to age groups, patients aged ≤50 years, between the ages of 51 and 70, and ≥71 years accounted for 16%, 44%, and 40%, respectively, in Group A. The corresponding figures in Group B were 18%, 36%, and 46%. The commonest site in Group A was the rectum (45.9%), followed by the descending colon and sigmoid colon (27.4%), and the ileocecum and ascending colon (20%). In Group B, the descending colon and sigmoid colon were the commonest site (41.7%), followed by the rectum (40.3%) and the ileocecum and ascending colon (9.7%). Patients in Group A tended to have colon cancer on the right side; it was observed in 23% of A-bomb survivors exposed at up to 2500 m from the hypocenter and in 14.8% of those exposed at a distance of over 2500 m. Histology revealed well differentiated adenocarcinoma in 78% in both groups. Both poorly differentiated and mucocellular adenocarcinomas occupied 13.4% in Group A, as compared with 4.2% in Group B. (N.K.)

  12. Monte-Carlo study on primary knock-on atom energy spectrum produced by neutron radiation

    International Nuclear Information System (INIS)

    Zhou Wei; Liu Yongkang; Deng Yongjun; Ma Jimin

    2012-01-01

    Computational method on energy distribution of primary knock-on atom (PKA) produced by neutron radiation was built in the paper. Based on the DBCN card in MCNP, reaction position, reaction type and energy transfer between neutrons and atoms were recorded. According to statistic of these data, energy and space distributions of PKAs were obtained. The method resolves preferably randomicity of random number and efficiency of random sampling computation. The results show small statistical fluctuation and well statistical. Three-dimensional figure of energy and space distribution of PKAs were obtained, which would be important to evaluate radiation capability of materials and study radiation damage by neutrons. (authors)

  13. A clinicopathological study on gastric cancer of the atomic-bomb survivors in Nagasaki, by autopsy cases

    International Nuclear Information System (INIS)

    Takahara, Osamu; Yoshida, Kuniko; Nakatani, Akira; Nakano, Masato.

    1986-01-01

    Autopsy findings of gastric cancer were examined in 265 patients consisting of those exposed at ≤ 2,000 m from the hypocenter (group 1), those exposed at > 2,000 m or those entering the city after the bombing (group 2), and non-exposed controls (group 3). The largest number of patients was in their sixties and seventies, irrespective of exposure status. Overall, the ratio of men to women was 1.6 : 1. The incidence of gastric cancer decreased up to 1975 in all groups. Thereafter, it began to increase, especially in group 1. The most common site of cancer was the pyloric antrum in all groups. Histologically, poorly differentiated type was observed most frequently in group 1; however, this was not statistically significant. Multiple primaries, which were unlikely to be related to exposure, were observed in 22 autopsy cases. (Namekawa, K.)

  14. Capsule summary of results of radiation studies on Hiroshima and Nagasaki atomic bomb survivors, 1945-75

    International Nuclear Information System (INIS)

    Moriyama, I.M.

    1978-04-01

    This is a summary in capsule form of the more significant findings of studies that have been conducted over the past 30 years. The growth and development in terms of height, weight, and head and chest circumferences were less for children in utero whose mothers were proximally exposed. Smaller head size and mental retardation appeared to be associated with radiation exposure. Mortality especially during infancy, was significantly higher among children exposed in utero, and increased with dose. Delayed effects of disease occurrence, particularly neoplasms, have been observed. Of special significance is the increased leukemia incidence with a clear-cut dose response relationship with the peak coming 6 years after exposure. Although the leukemia rates in the high dose groups have declined persistently from 1950 to 1972, they have not yet reached the level experienced by the general population. For the solid tumors, lung cancer, thyroid cancer, salivary gland tumors, breast cancer, cancer of the esophagus, stomach and the urinary tract, and lymphomas have been found to be associated with A-bomb radiation exposure. The latent period for the solid tumors appears to be less than 20 years. After a latent period of about 15 years, children who received 100 rad or more A-bomb radiation have begun to develop an excess of malignancies. Some 25 years or more after exposure, the accumulated increase of cancer is relatively high, with no indication that a peak has been reached. Radiation induced chromosome aberrations in survivors continue to persist, and the aberration frequency is, in general, proportional to the radiation dose received. To date, there is no evidence of a relationship between radiation dose and the other diseases. (author)

  15. Comparison of medical data of atomic-bomb survivors resident in the U.S. and Hiroshima

    International Nuclear Information System (INIS)

    Ito, Chikako; Matsubara, Hiroomi; Yamakido, Michio; Yamada, Hiroaki.

    1982-01-01

    The third medical examination of A-bomb survivors residing in the U.S. was performed in San Francisco, Los Angeles, Seattle and Honolulu during the period 6 - 28 May 1981. The test results were studied and the actual state of the survivors in the U.S., was reviewed as explained hereunder. 1) The number of survivors actually registered with the Committee of A-bomb Survivors in the U.S. is 491 (133 males and 358 females) of whom 57.2% are U.S. citizens. Those exposed in Hiroshima accounted for 91.8%. The mean age was 53.3 +- 8.9, thus they were more than 3 years younger than their counterparts in Hiroshima. The present addresses of the survivors are distributed over 15 states, but those in California constitute 77.6% of the total, and when those residing in the states along the west coast and Hawaii are added the rate increases to 95.9%. 2) Those who underwent health examination numbered 166 (45 males and 121 females), and comparison of the U.S. survivors against the Hiroshima survivors showed there to be a difference in the following points. The prevalence of hypertension was lower among the U.S. survivors, but RBC counts and hemoglobin concentration were significantly higher. The same was observed for blood lipids with hypercholesterolemia and hypertriglyceridemia being found at a significantly higher rate in the U.S. survivors. 3) Those free of clinical abnormalities in this survey were 37.3%, and the rest required dietary guidance, follow-up observation, detailed examination of treatment. Those with diseases which are considered would make them eligible for health management allowance if in Japan, accounted for 18.7%. (author)

  16. Reassessment of diagnosis and subtyping of leukemias among atomic bomb survivors, 4. Combined analysis of Hiroshima and Nagasaki cases

    Energy Technology Data Exchange (ETDEWEB)

    Tomonaga, Masao; Kuriyama, Kazutaka; Ichimaru, Michito; Matsuo, Tatsuki; Finch, S.C.; Imanaka, Fumio; Kuramoto, Atsushi; Kamada, Nanao.

    1988-03-01

    In evaluable 456 (60 %) of 750 leukemic patients exposed at less than or equal to9,000 m from the hypocenter, diagnosis and subtypes of leukemia were reevaluated in relation to radiation doses and age at the time of bombing using a new classification method of French-American-British (FAB). The FAB classification diagnosed 63 patients (13.5 %) as acute lymphoid leukemia (ALL), 181 (39.0 %) as acute myeloid leukemia (AML), 26 (5.6 %) as myelodysplastic syndrome (MDS), 106 (22.8 %) as chronic myeloid leukemia (CML), 39 (7.5 %) as adult T-cell leukemia, and 5 (0.8 %) as chronic lymphocytic leukemia. According to radiation doses, the incidence of CML increased in the group exposed to one to 99 cGy; the incidences of ALL and MDS increased in the group exposed to greater than or equal to100 cGy. The incidence of CML was definitively higher in Hiroshima than Nagasaki in all groups; this was noted in the group exposed to 0 cGy (approximately 2.5 times higher). The incidences of ALL and MDS showed a tendency to increase in proportion to radiation doses. In the group exposed to greater than or equal to100 cGy, the incidences of ALL, CML, and MDS increased in patients younger than 15 years, those aged 16 - 35 years, and those older than 36 years, respectively, at the time of the bombing. In this group, there were also differences in latent period (10 yr in ALL and CML, 15 yr in AML, and 17 yr in MDS). None of the AML patients in the group exposed to greater than or equal to100 cGy had M3. (Namekawa, K.).

  17. Neutron Diffraction Studies of the Atomic Vibrations of Bulk and Surface Atoms of Nanocrystalline SiC

    Science.gov (United States)

    Stelmakh, S.; Grzanka, E.; Zhao, Y.; Palosz, W.; Palosz, B.

    2004-01-01

    Thermal atomic motions of nanocrystalline Sic were characterized by two temperature atomic factors B(sub core), and B(sub shell). With the use of wide angle neutron diffraction data it was shown that at the diffraction vector above 15A(exp -1) the Wilson plots gives directly the temperature factor of the grain interior (B(sub core)). At lower Q values the slope of the Wilson plot provides information on the relative amplitudes of vibrations of the core and shell atoms.

  18. Report on the results of the eleventh medical examination of atomic bomb survivors resident in North America

    Energy Technology Data Exchange (ETDEWEB)

    Yamakido, Michio [Hiroshima Univ. (Japan). School of Medicine; Dohy, Hiroo; Neriishi, Kazuo [and others

    1998-01-01

    The 11th medical examination of A-bomb survivors was conducted in 1997. Two medical teams conducted health examinations in Los Angeles and Seattle, and in San Francisco and Hawaii, respectively. The total number of A-bomb survivors resident in North America as of the end of July 1997 was 1,060, an increase of 17 over that confirmed in 1995. The number of survivors exposed <2,000-m from the hypocenter was 234, accounting for 22.1% of the total. The confirmed number of in-utero exposed survivors was 26. As to the past medical history information, breast cancer, thyroid cancer, and heart disease were frequently observed in the <2,000-m group. Frequent subjective symptoms include complete exhaustion or fatigue, loss of vigor, blurring of vision, itching of the skin, which were reported in more than 40% of the survivors. The frequencies of nocturia, nervousness, severe headache, and excessive sweating in cold weather were higher in the <2,000-m group. Chest pain was seen frequently in the <2,000-m group for males, but no difference was observed in females. Nocturia was observed in more than half of the males in the <2,000-m group. There were 99 cases (22.8%) with fasting plasma glucose level of 110 mg/dl or above, consisting of 39 males (32.0%) and 60 females (19.2%). Abnormal HbA1c levels were observed in 33 cases (7.6%), including 12 males (9.8%) and 11 females (6.7%). The proportion of cases with abnormal HbA1c levels was higher in males. No difference by exposure status was observed either for fasting plasma glucose or HbA1c. The disease of the highest prevalence was hyperlipidemia (57.4%), followed by hypertension (35.0%), obesity (27.2%), liver disease (21.9%), thyroid disease (20.0%), gastrointestinal disease (20.7%), heart disease (13.4%) and urological disease (12.9%). Malignant tumors were observed in two cases in L.A., two in Seattle, and one in S.F. Cancer will be important issue in the future examinations. (K.H.)

  19. Atomic bomb irradiation-induced leukemias revisited. Summary data of 50 years-long term follow up study on survivors

    Energy Technology Data Exchange (ETDEWEB)

    Tomonaga, Masao [Nagasaki Univ. (Japan). Atomic Disease Inst.; Matsuo, Tatsuki; Preston, D.L.; Bennett, J.M.

    1997-12-01

    The Life Span Study (LSS) on 93,741 survivors (fixed cohort) and the Open City Study (OCS) on all survivors (unfixed) irrespective of whether they belonged to LSS or not, have been conducted in parallel over 45 years to ensure reliable case detection. We adopted the FAB classification for acute leukemias and for exposure dose of individual survivors, the new dosimetry system 1986 (DS86). In LSS, 221 leukemia cases were analysed. There was strong evidence of radiation-induced risks for acute myeloid leukemia (AML), acute lymphoid leukemia (ALL) and chronic myeloid leukemia (CML), but not for adult T-cell leukemia and chronic lymphocytic leukemia. There was also significant difference between three major types with respect to the effects of age at bombing and sex, and in the temporal pattern of the elevated risks. For AML the dose response function was non-linear, whereas there was no evidence against linearity for ALL and CML. The hypothesis of a 0.5 Gy threshold could be rejected for three major types of leukemia. Excess Absolute Risk (EAR) estimates in cases per 10,000 Person Year Sievert (PYSv) were 0.6, 1.1, 0.9 for ALL, AML and CML, respectively. The corresponding relative risk at 1.0 Sv were 9.1, 3.3, 6.2, respectively. Although childhood exposure <15 age at bombing apparently induced three major types, the age-related highest risk was observed for ALL. In OCS, 413 cases with DS86 estimates were used for analysis. Type specific incidence rates were calculated indirectly by using the over all incidence of leukemia from LSS data and multiplying these values by the corresponding proportions of cases in OCS. In conjunction with LSS data, the effects of radiation were significantly greater on the incidences of ALL and CML than on that of AML. In the high dose group there was a strong evidence for shorter incubation time and faster decline of elevated risk for ALL and CML than for AML. AML risk was apparently persistent through 1980. (K.H.)

  20. Atomic bomb irradiation-induced leukemias revisited. Summary data of 50 years-long term follow up study on survivors

    International Nuclear Information System (INIS)

    Tomonaga, Masao; Matsuo, Tatsuki; Preston, D.L.; Bennett, J.M.

    1997-01-01

    The Life Span Study (LSS) on 93,741 survivors (fixed cohort) and the Open City Study (OCS) on all survivors (unfixed) irrespective of whether they belonged to LSS or not, have been conducted in parallel over 45 years to ensure reliable case detection. We adopted the FAB classification for acute leukemias and for exposure dose of individual survivors, the new dosimetry system 1986 (DS86). In LSS, 221 leukemia cases were analysed. There was strong evidence of radiation-induced risks for acute myeloid leukemia (AML), acute lymphoid leukemia (ALL) and chronic myeloid leukemia (CML), but not for adult T-cell leukemia and chronic lymphocytic leukemia. There was also significant difference between three major types with respect to the effects of age at bombing and sex, and in the temporal pattern of the elevated risks. For AML the dose response function was non-linear, whereas there was no evidence against linearity for ALL and CML. The hypothesis of a 0.5 Gy threshold could be rejected for three major types of leukemia. Excess Absolute Risk (EAR) estimates in cases per 10,000 Person Year Sievert (PYSv) were 0.6, 1.1, 0.9 for ALL, AML and CML, respectively. The corresponding relative risk at 1.0 Sv were 9.1, 3.3, 6.2, respectively. Although childhood exposure <15 age at bombing apparently induced three major types, the age-related highest risk was observed for ALL. In OCS, 413 cases with DS86 estimates were used for analysis. Type specific incidence rates were calculated indirectly by using the over all incidence of leukemia from LSS data and multiplying these values by the corresponding proportions of cases in OCS. In conjunction with LSS data, the effects of radiation were significantly greater on the incidences of ALL and CML than on that of AML. In the high dose group there was a strong evidence for shorter incubation time and faster decline of elevated risk for ALL and CML than for AML. AML risk was apparently persistent through 1980. (K.H.)

  1. Radial plasma profile and neutron yield in an adiabatic trap with fast atom injection

    International Nuclear Information System (INIS)

    Panov, D.A.

    1988-01-01

    Radial profiles of ion densities depending on two dimensionless parameters, which values are determined by the trap, plasma and injected beam parameters are found in dimensionless units for a plasma generated by fast atom injection in an adiabatic trap. The calculated profiles are used for determining the neutron yield. Simple approximated dimensional relations permitting to estimate quickly neutron yield, required injection power, flux of charge exchange atoms on the wall around the plasma in a wide energy range of injected atoms, trap field modulud, injection angle, trap radius and length are determined. The energetic efficiency of neutron production is estimated and it is shown that it grows with the injection energy. 7 refs.; 7 figs

  2. The story of an A-bomb by Oppenheimer

    Energy Technology Data Exchange (ETDEWEB)

    Song, Eun Yeong

    2005-06-15

    This book concentrates on an A-bomb by Oppenheimer. It is divided into eleven class, which are exile of excellent scientists, uranium atomic fission, situation the U.S. and Germany I, situation the U.S. and Germany II, air strike in pearl Harbor, plan for development of an A-bomb, military action to blow up heavy water plant, select on spot to drop an A-bomb, surrender and drop for an A-bomb and science of an A-bomb. This book is written to explain an A-bomb with form of storytelling.

  3. Report on results of third medical examination of Atomic Bomb Survivors residing in the U.S

    International Nuclear Information System (INIS)

    Matsubara, Hiroomi; Yamakido, Michio; Ito, Chikako; Yamada, Hiroaki.

    1982-01-01

    The number of survivors actually registered with the Committee of A-bomb survivors in the U.S. in 491 (133 males and 358 females) of whom 57.3% are U.S. citizens. Those exposed in Hiroshima accounted for 91.8%. The mean age was 53.3 +- 8.9, thus they were more than 3 years younger than their counterparts in Hiroshima. Responses to the Health Survey Questionnaires numbered 255, and those with symptoms which appeared to be related to diseases were found at a high rate among the early entrants, but as the number of those receiving examination in this group was few, it is considered that many of those in poor health had come in for the examination. No association could be demonstrated between psychological complaints and exposure status. Those who underwent health examination numbered 166 (45 males and 121 females), and comparison of the U.S. survivors against the Hiroshima survivors showed there to be a difference in the following points. The prevalence of hypertension was lower among the U.S. survivors, but RBC counts and hemoglobin values were significantly higher. The same was observed for blood lipids with hypercholesterolemia and hypertriglyceridemia being found at a significantly higher rate in the U.S. survivors, the cause being considered to be the larger intake of animal fat and sugar by those of Japanese ancestry than the indigenous Japanese. Those free of clinical abnormalities in this survey were 37.3%, and the rest required dietary guidance, follow-up observation, detailed examination or treatment. Those with diseases which are considered would make them eligible for health management allowance if in Japan, accounted for 18.7%. (J.P.N.)

  4. Breast cancer risk in atomic bomb survivors from multi-model inference with incidence data 1958-1998

    International Nuclear Information System (INIS)

    Kaiser, J.C.; Jacob, P.; Meckbach, R.; Cullings, H.M.

    2012-01-01

    Breast cancer risk from radiation exposure has been analyzed in the cohort of Japanese a-bomb survivors using empirical models and mechanistic two-step clonal expansion (TSCE) models with incidence data from 1958 to 1998. TSCE models rely on a phenomenological representation of cell transition processes on the path to cancer. They describe the data as good as empirical models and this fact has been exploited for risk assessment. Adequate models of both types have been selected with a statistical protocol based on parsimonious parameter deployment and their risk estimates have been combined using multi-model inference techniques. TSCE models relate the radiation risk to cell processes which are controlled by age-increasing rates of initiating mutations and by changes in hormone levels due to menopause. For exposure at young age, they predict an enhanced excess relative risk (ERR) whereas the preferred empirical model shows no dependence on age at exposure. At attained age 70, the multi-model median of the ERR at 1 Gy decreases moderately from 1.2 Gy -1 (90% CI 0.72; 2.1) for exposure at age 25 to a 30% lower value for exposure at age 55. For cohort strata with few cases, where model predictions diverge, uncertainty intervals from multi-model inference are enhanced by up to a factor of 1.6 compared to the preferred empirical model. Multi-model inference provides a joint risk estimate from several plausible models rather than relying on a single model of choice. It produces more reliable point estimates and improves the characterization of uncertainties. The method is recommended for risk assessment in practical radiation protection. (orig.)

  5. Breast cancer risk in atomic bomb survivors from multi-model inference with incidence data 1958-1998

    Energy Technology Data Exchange (ETDEWEB)

    Kaiser, J.C.; Jacob, P.; Meckbach, R. [Institute of Radiation Protection, Helmholtz-Zentrum Muenchen, German Research Centre for Environmental Health, Neuherberg (Germany); Cullings, H.M. [Radiation Effects Research Foundation, Department of Statistics, Hiroshima (Japan)

    2012-03-15

    Breast cancer risk from radiation exposure has been analyzed in the cohort of Japanese a-bomb survivors using empirical models and mechanistic two-step clonal expansion (TSCE) models with incidence data from 1958 to 1998. TSCE models rely on a phenomenological representation of cell transition processes on the path to cancer. They describe the data as good as empirical models and this fact has been exploited for risk assessment. Adequate models of both types have been selected with a statistical protocol based on parsimonious parameter deployment and their risk estimates have been combined using multi-model inference techniques. TSCE models relate the radiation risk to cell processes which are controlled by age-increasing rates of initiating mutations and by changes in hormone levels due to menopause. For exposure at young age, they predict an enhanced excess relative risk (ERR) whereas the preferred empirical model shows no dependence on age at exposure. At attained age 70, the multi-model median of the ERR at 1 Gy decreases moderately from 1.2 Gy{sup -1} (90% CI 0.72; 2.1) for exposure at age 25 to a 30% lower value for exposure at age 55. For cohort strata with few cases, where model predictions diverge, uncertainty intervals from multi-model inference are enhanced by up to a factor of 1.6 compared to the preferred empirical model. Multi-model inference provides a joint risk estimate from several plausible models rather than relying on a single model of choice. It produces more reliable point estimates and improves the characterization of uncertainties. The method is recommended for risk assessment in practical radiation protection. (orig.)

  6. Neutron detection using CR-39 and Atomic Force Microscopy (AFM)

    International Nuclear Information System (INIS)

    Vazquez L, C.; Fragoso, R.; Felix, R.; Golzarri, J.I.; Espinosa, G.; Castillo, F.

    2007-01-01

    AFM has been applied in many CR-39 track formation analyses. In this paper, the use of AFM in the neutron detection and analysis of the track formation is reported. The irradiation was made with an 1.5 GBq (0.5 Ci) 241 Am-Be neutron source, with and without a polyethylene radiator. The surface analysis was made to the CR-39 fresh material without irradiation, after the irradiation, and after a very short etching time. The results show important differences between the irradiation, with and without polyethylene radiator, and the latent tracks of the neutron in the CR-39 polycarbonate. The development of track formation after very short etching time and pits characterization were measured too using the AFM facilities. (Author)

  7. Neutron data compilation at the International Atomic Energy Agency

    International Nuclear Information System (INIS)

    Lemmel, H.D.; Attree, P.M.; Byer, T.A.; Good, W.M.; Hjaerne, L.; Konshin, V.A.; Lorens, A.

    1968-03-01

    The paper describes the present status of the neutron data compilation center of the IAEA Nuclear Data Unit, which is now in full operation. An outline i s given of the principles and objectives, the working routines, and the services available within the two-fold functions of the Unit: a) to promote cooperation and international neutron data exchange between the four major centers at Brookhaven, Saclay, Obninsk and Vienna, which share responsibilities in a geographical distribution of labour; b) to collect systematically the neutron data arising from countries in East Europe, Asia, Australia, Africa, South and Central America and to offer certain services to these countries. A brief description of DASTAR, the DAta STorage And Retrieval system, and of CINDU, the data Catalog of the JAEA Nuclear Data Unit, is given. (author)

  8. Summary of the studies at ABCC-RERF concerning the late hematologic effects of atomic bomb exposure in Hiroshima and Nagasaki

    International Nuclear Information System (INIS)

    Finch, S.C.; Finch, C.A.

    1990-06-01

    The most significant late hematologic effect of atomic bomb radiation exposure in the populations of Hiroshima and Nagasaki has been the increased occurrence of leukemia. The radiation effect for leukemia has disappeared in Nagasaki but slightly elevated rates still exist in Hiroshima. Multiple myeloma also is radiation-related, but there is only a suggestive relationship for malignant lymphoma. No evidence exists of a late radiation effect for primary disturbances of hematopoiesis in the absence of malignant disease. Somatic hematopoietic markers of previous radiation exposure include lymphocyte chromosomal aberrations and an increased frequency of mutant T-lymphocytes deficient in hypoxanthine phosphoribosyltransferase. A radiation effect also has been observed for the frequency of mutant erythrocytes lacking expression of glycophorin-A protein on the membrane. There is no evidence for radiation-induced disturbance of granulocyte function, but age-related accelerated decline in the immunological functions of T lymphocytes and age-related alteration in the number of certain subsets of circulating T and B lymphocytes appears to be radiation-related. A number of radiation-related hematology research proposals which might be considered for the future are included in this report. (author) 92 refs

  9. Effects of atomic bomb radiation on differentiation of B lymphocytes and on the function of concanavalin A-induced suppressor T lymphocytes

    International Nuclear Information System (INIS)

    Yamada, Y.; Neriishi, S.; Ishimaru, T.; Shimba, N.; Hamilton, H.B.; Ohgushi, Y.; Koyanagi, M.; Ichimaru, M.

    1985-01-01

    The differentiation of peripheral blood B lymphocytes into immunoglobulin-producing cells (Ig-PC) by pokeweed mitogen (PWM) and the function of concanavalin A (Con A)-induced suppressor T lymphocytes were examined to elucidate the late effects of atomic bomb radiation. A total of 140 individuals, 70 with an exposure dose of 100 rad or more and an equal number with an exposure dose of 0 rad matched by sex and age, were selected from the Nagasaki Adult Health Study (AHS) sample. Both the differentiation of peripheral blood B lymphocytes into Ig-PC by PWM and the function of Con A-induced suppressor T lymphocytes tended to be more depressed in the exposed group than in the control group, but a statistically significant difference could not be observed between the two groups. The function of Con A-induced suppressor T lymphocytes tended to decrease with age, but a statistical significance was detected only for percentage suppression against IgM-PC

  10. A study on social life and mental health of middle-aged and elderly atomic bomb survivors. Analysis of general health questionnaire (GHQ-30)

    International Nuclear Information System (INIS)

    Ohta, Yasuyuki; Mine, Mariko; Honda, Sumihisa; Toriyama, Fumiko; Sugasaki, Hiroyuki.

    1996-01-01

    The psychological state of middle aged and elderly atomic bomb survivors was analyzed by GHQ, which had been done from September to November, 1992. Subjects were 1,399 Nagasaki survivors of the average age of 61.3 y and 1,054 non-irradiated people of 62.2 y living in the countryside of Nagasaki prefecture as the control. Analyses were performed with χ square method and t-test. When the subordinate measure derived from factor analysis of GHQ was compared with that of the control group, the score possibly attributable to anxiety reaction to the stress was significantly higher in the survivors. However, the two scores attributable to obstacle in personal relations and to avoidance of social activities were significantly lower, which suggested that the survivors are able to have rich personal and social interactions. Besides, it was suggested that the GHQ score was increased possibly by anxiety for the future in the essential part of life such as loss of feeling of healthiness and dissatisfaction for the present life conditions. It was confirmed that systematic and continuous examinations are necessary from the bio-psycho-social viewpoint. (H.O.)

  11. About disturbances of the skin and other organs, detected in atomic bomb survivors who were irradiated within 1 km from the hypocenter of Hiroshima and were examined by the human dry dock, at the 41st year after bombing

    International Nuclear Information System (INIS)

    Niimi, Masanobu; Takemoto, Masao; Fujii, Atsushi

    1990-01-01

    Hiroshima City Funairi Hospital has performed periodic medical examinations for 32,397 A-bomb survivors up to 1988. This is an analysis of 266 A-bomb survivors exposed within 1,000 m from the hypocenter. At the time of A-bombing, 41, 26, and 132 A-bomb survivors had sustained both burns and injuries, burns, and injuries, respectively. According to the exposure status, the incidence of burns in the presence of shielding was one fifth that in the absence of shielding. Medical examinations revealed the highest incidence of cardiovascular and endocrine diseases in the middle-aged or elderly people. According to malignancy, one had gastric cancer, and one had liver cancer. There was no correlation between the exposure distance and both disease incidence and contents. People participating in periodic medical examinations at short-term intervals had smaller number of diseases in every age group, as compared with those participating at long-term intervals. The significance of periodic medial examinations is discussed. (N.K.)

  12. 'DIRTY BOMB' and its countermeasures

    International Nuclear Information System (INIS)

    Wang Shanqiang; Zou Shiya; Zhang Wenzhong

    2008-01-01

    'Dirty bomb', one of the three nuclear and radiological terrorism attack events, is a kind of weapon using conventional explosive to disperse radioactive materials, which leads to harmful and serious environmental contamination with α, β, γ rays and neutron having high radioactivity activity. This paper mainly introduces the characteristics and hazards, and puts forward some recommendations to counter RDD based on current international and national situations in nuclear and radiological terrorisms. (authors)

  13. Inelastic Neutron Scattering, Dynamics of Atoms and Novel Material Properties

    Science.gov (United States)

    Chaplot, S. L.

    2010-12-01

    We review our research on properties of two important functional materials in which dynamics plays an essential role, namely, fast-ion conductors and negative thermal expansion materials. We bring out the underlying role of the lattice dynamics in terms of the soft phonon modes in both cases. Then, using molecular dynamics simulation we show the mechanism of the fast-ion conduction that occurs at about 0.8 times the overall melting temperature in Li2O, UO2 and ThO2. We obtain numerical measures of the phonon anharmonicity from neutron-inelastic experiments and also lattice dynamics computations and quantitatively derive the negative expansion coefficient in several crystalline materials that is found to match well with direct diffraction measurements.

  14. Neutron diffraction study of ordering of atoms and antiphase domains in titanium carbohydrides

    International Nuclear Information System (INIS)

    Mukhtarova, N. N.; Getmanskiy, V. V.

    2004-01-01

    Hydrogen effects greatly properties and structure of refractory titanium carbide which is essential in the technique described. To obtain carbohydrides with the largest concentrations of hydrogen and Ti carbides that have given service characteristics, structural features of these materials should be known. In the present work the Ti carbohydrides of different compositions at the lower limit of homogeneity range were studied by means of X-ray and powder neutron diffraction. Neutron diffraction patterns were obtained using the neutron diffractometer mounted at the thermal column of the atomic reactor of the INP AS RUz (λ = 1.085 A). The treatment of neutron diffraction patterns was carried out by the Rietweld full-profile analysis (program of DBW 3.2). Samples of carbohydrides TiC x H y were prepared by mean sintering. Treatment of samples was carried out in evacuated and sealed quartz ampoules, thus preventing hydrogen escape from the samples. Concentration of carbon and hydrogen atoms in the samples was controlled by chemical and neutron diffraction analysis. This work was supported by the Center of Science and Technology of Uzbekistan (contract Φ - 2.1.2)

  15. Energy spectra of primary knock-on atoms under neutron irradiation

    International Nuclear Information System (INIS)

    Gilbert, M.R.; Marian, J.; Sublet, J.-Ch.

    2015-01-01

    Materials subjected to neutron irradiation will suffer from a build-up of damage caused by the displacement cascades initiated by nuclear reactions. Previously, the main “measure” of this damage accumulation has been through the displacements per atom (dpa) index, which has known limitations. This paper describes a rigorous methodology to calculate the primary atomic recoil events (often called the primary knock-on atoms or PKAs) that lead to cascade damage events as a function of energy and recoiling species. A new processing code SPECTRA-PKA combines a neutron irradiation spectrum with nuclear recoil data obtained from the latest nuclear data libraries to produce PKA spectra for any material composition. Via examples of fusion relevant materials, it is shown that these PKA spectra can be complex, involving many different recoiling species, potentially differing in both proton and neutron number from the original target nuclei, including high energy recoils of light emitted particles such as α-particles and protons. The variations in PKA spectra as a function of time, neutron field, and material are explored. The application of PKA spectra to the quantification of radiation damage is exemplified using two approaches: the binary collision approximation and stochastic cluster dynamics, and the results from these different models are discussed and compared. - Highlights: • Recoil cross-section matrices under neutron irradiation are generated. • Primary knock-on atoms (PKA) spectra are calculated for fusion relevant materials. • Variation in PKA spectra due to changes in geometry are considered. • Inventory simulations to consider time-evolution in PKA spectra. • Damage quantification using damage functions from different approximations.

  16. Platinum assay by neutron activation analysis and atomic absorption spectroscopy in cisplatin treated pregnant mice

    International Nuclear Information System (INIS)

    Esposito, M.; Collecchi, P.; Oddone, M.; Meloni, S.

    1987-01-01

    Cisplatin (CDDP) is an antineoplastic drug used in the treatment of a wide variety of tumors. This paper describes an investigation carried out on pregnant mice after intragastric or intraperitoneal treatment with CDDP from the 11st to 13rd day of gestation. Platinum content in different liver, kidney, placenta and brain tissues, was determined at 18. day of pregnancy. Neutron activation analysis and atomic absorption spectroscopy were used. Results of both techniques are presented and discussed in terms of precision, accuracy and sensitivity. Neutron activation analysis appears to provide better results correlated with the drug treatment. (author) 10 refs.; 4 tables

  17. Hot atom reactions in neutron irradiated solid iron group metallocenes

    International Nuclear Information System (INIS)

    Yassine, T.; Blackburn, R.

    1990-01-01

    Investigation of the hot reactions of the recoil metal nuclides in neutron irradiated solid ferrocene, ruthenocene and osmocene shows that the retention decreases from ferrocene to osmocene. This observation is ascribed to the effects of recoil energy and the size of the hot zone. The large isotope effect observed between osmium isotopes and between ruthenium isotopes are explained as resulting from the effect of the Auger ionisation produced by internal conversion which takes place in Os-185 and Ru-97 to a greater degree than in their other isotopes. Irradiation of solid metallocenes diluted with an inert solid (silica) showed that the retention in ruthenocene is high and only slightly less than for the pure case whilst the retention of osmocene is very small and the retention of ferrocene is almost zero. The high retention in solid diluted ruthenocene was tentatively attributed to a combination of primary retention resulting from γ cancellation and uptake of recoil momentum by the solid lattice. (author) 15 refs. 5 tabs. 2 figs

  18. Reviews Equipment: Vibration detector Equipment: SPARK Science Learning System PS-2008 Equipment: Pelton wheel water turbine Book: Atomic: The First War of Physics and the Secret History of the Atom Bomb 1939-49 Book: Outliers: The Story of Success Book: T-Minus: The Race to the Moon Equipment: Fridge Rover Equipment: Red Tide School Spectrophotometer Web Watch

    Science.gov (United States)

    2010-03-01

    WE RECOMMEND Vibration detector SEP equipment measures minor tremors in the classroom SPARK Science Learning System PS-2008 Datalogger is easy to use and has lots of added possibilities Atomic: The First War of Physics and the Secret History of the Atom Bomb 1939-49 Book is crammed with the latest on the atom bomb T-Minus: The Race to the Moon Graphic novel depicts the politics as well as the science Fridge Rover Toy car can teach magnetics and energy, and is great fun Red Tide School Spectrophotometer Professional standard equipment for the classroom WORTH A LOOK Pelton wheel water turbine Classroom-sized version of the classic has advantages Outliers: The Story of Success Study of why maths is unpopular is relevant to physics teaching WEB WATCH IOP webcasts are improving but are still not as impressive as Jodrell Bank's Chromoscope website

  19. Derivation of Inter-Atomic Force Constants of Cu2O from Diffuse Neutron Scattering Measurement

    Directory of Open Access Journals (Sweden)

    T. Makhsun

    2013-04-01

    Full Text Available Neutron scattering intensity from Cu2O compound has been measured at 10 K and 295 K with High Resolution Powder Diffractometer at JRR-3 JAEA. The oscillatory diffuse scattering related to correlations among thermal displacements of atoms was observed at 295 K. The correlation parameters were determined from the observed diffuse scattering intensity at 10 and 295 K. The force constants between the neighboring atoms in Cu2O were estimated from the correlation parameters and compared to those of Ag2O

  20. A comparison of the risk of stillbirth associated with paternal pre-conception irradiation in the Sellafield workforce with that of stillbirth and untoward pregnancy outcome among Japanese atomic bomb survivors

    International Nuclear Information System (INIS)

    Little, M.P.

    1999-01-01

    A comparison is made of the relative risks associated with paternal pre-conception irradiation of stillbirth and untoward pregnancy outcome (stillbirths, congenital malformations, neonatal deaths) in the offspring of the Japanese atomic bomb survivors and of stillbirth in the offspring of Sellafield workers. It is concluded that the pre-conception exposure risks of stillbirth in the offspring of Sellafield workers are statistically incompatible with the Japanese data at the 5% level. Other human and experimental data relating to the induction of congenital abnormalities are briefly reviewed. (author)

  1. Sub-atomic resolution X-ray crystallography and neutron crystallography: promise, challenges and potential.

    Science.gov (United States)

    Blakeley, Matthew P; Hasnain, Samar S; Antonyuk, Svetlana V

    2015-07-01

    The International Year of Crystallography saw the number of macromolecular structures deposited in the Protein Data Bank cross the 100000 mark, with more than 90000 of these provided by X-ray crystallography. The number of X-ray structures determined to sub-atomic resolution (i.e. ≤1 Å) has passed 600 and this is likely to continue to grow rapidly with diffraction-limited synchrotron radiation sources such as MAX-IV (Sweden) and Sirius (Brazil) under construction. A dozen X-ray structures have been deposited to ultra-high resolution (i.e. ≤0.7 Å), for which precise electron density can be exploited to obtain charge density and provide information on the bonding character of catalytic or electron transfer sites. Although the development of neutron macromolecular crystallography over the years has been far less pronounced, and its application much less widespread, the availability of new and improved instrumentation, combined with dedicated deuteration facilities, are beginning to transform the field. Of the 83 macromolecular structures deposited with neutron diffraction data, more than half (49/83, 59%) were released since 2010. Sub-mm(3) crystals are now regularly being used for data collection, structures have been determined to atomic resolution for a few small proteins, and much larger unit-cell systems (cell edges >100 Å) are being successfully studied. While some details relating to H-atom positions are tractable with X-ray crystallography at sub-atomic resolution, the mobility of certain H atoms precludes them from being located. In addition, highly polarized H atoms and protons (H(+)) remain invisible with X-rays. Moreover, the majority of X-ray structures are determined from cryo-cooled crystals at 100 K, and, although radiation damage can be strongly controlled, especially since the advent of shutterless fast detectors, and by using limited doses and crystal translation at micro-focus beams, radiation damage can still take place. Neutron

  2. Sub-atomic resolution X-ray crystallography and neutron crystallography: promise, challenges and potential

    Directory of Open Access Journals (Sweden)

    Matthew P. Blakeley

    2015-07-01

    Full Text Available The International Year of Crystallography saw the number of macromolecular structures deposited in the Protein Data Bank cross the 100000 mark, with more than 90000 of these provided by X-ray crystallography. The number of X-ray structures determined to sub-atomic resolution (i.e. ≤1 Å has passed 600 and this is likely to continue to grow rapidly with diffraction-limited synchrotron radiation sources such as MAX-IV (Sweden and Sirius (Brazil under construction. A dozen X-ray structures have been deposited to ultra-high resolution (i.e. ≤0.7 Å, for which precise electron density can be exploited to obtain charge density and provide information on the bonding character of catalytic or electron transfer sites. Although the development of neutron macromolecular crystallography over the years has been far less pronounced, and its application much less widespread, the availability of new and improved instrumentation, combined with dedicated deuteration facilities, are beginning to transform the field. Of the 83 macromolecular structures deposited with neutron diffraction data, more than half (49/83, 59% were released since 2010. Sub-mm3 crystals are now regularly being used for data collection, structures have been determined to atomic resolution for a few small proteins, and much larger unit-cell systems (cell edges >100 Å are being successfully studied. While some details relating to H-atom positions are tractable with X-ray crystallography at sub-atomic resolution, the mobility of certain H atoms precludes them from being located. In addition, highly polarized H atoms and protons (H+ remain invisible with X-rays. Moreover, the majority of X-ray structures are determined from cryo-cooled crystals at 100 K, and, although radiation damage can be strongly controlled, especially since the advent of shutterless fast detectors, and by using limited doses and crystal translation at micro-focus beams, radiation damage can still take place

  3. Summary of fifty years research on the late effects of atomic bomb irradiation in Japan with special reference to possible similar late effects by nuclear weapons tests in Semipalatinsk

    International Nuclear Information System (INIS)

    Tomonaga, M.

    2000-01-01

    The investigation clearly demonstrated statistically significant increases of risks for acute myeloid and lymphoid leukemia, chronic myeloid leukemia, and solid tumors including thyroid cancer, gastrointestinal cancers, lung cancer, hepatoma and skin cancer. The excess relative risks was highest for acute lymphoid leukemia, followed by chronic myeloid leukemia, acute myeloid leukemia, and solid cancer. The increased risk for leukemia has almost completely disappeared after 50 years, whereas the risks for cancers are apparently persisting giving a great threat to general health of atomic bomb survivors. These observations can be directly referred to the possible late effects of the acute and chronic exposure to irradiation caused by nuclear tests in Semipalatinsk region. Recent dose-estimation efforts by Kazakhstan, US and Japanese scientists indicated that there had been Hiroshima/Nagasaki atomic bomb equivalent high-dose exposure in some residents around the test sites. Some researchers suggested increased risks for malignant diseases such as leukemia and cancers. Unfortunately there was a lack of high-quality statistics in the Semipalatinsk survey, providing a considerable difficulty in interpreting the estimated incidences of such malignant diseases

  4. Effects of 252Cf neutrons, transmitted through an iron block on human lymphocyte chromosome

    International Nuclear Information System (INIS)

    Tanaka, K.; Hoshi, M.; Sawada, S.; Kamada, N.

    1994-01-01

    Chromosome aberration of human peripheral blood lymphocytes exposed to californium-252 ( 252 Cf) neutrons transmitted through a 15 cm thick iron block was analysed. The spectrum of the filtered neutrons ranged from 0.1 to 2MeV with a peak at 0.7 MeV, simulating the Hiroshima atomic bomb neutron spectrum as shown in the Dosimetry System 1986 (DS86). Chromosome aberration frequencies after exposure to filtered and unfiltered 252 Cf radiation were compared. Acentric ring chromosomes were significantly increased (p 0.1). The relative biological effectiveness (RBE) of the neutrons with respect to the formation of dicentrics and centric rings was 10.9 and 12.3 in the filtered and unfiltered conditions respectively, but the difference was not statistically significant. These results provide useful information for the re-evaluation of the biological effect of the Hiroshima atomic bomb radiations. (Author)

  5. Neutron activation analysis and atomic absorption spectrophotometry for the analysis of fresh, pasteurised and powder milk

    International Nuclear Information System (INIS)

    Wasim, M.; Rehman, S.; Arif, M.; Fatima, I.; Zaidi, J.H.

    2012-01-01

    This study shows the application of semi-absolute k 0 instrumental neutron activation analysis (k 0 -INAA), epithermal neutron activation analysis (ENAA) and atomic absorption spectrophotometry (AAS) for the determination of 21 elements (Br, Ca, Cl, Co, Cr, Cs, Cu, Fe, Hf, I, K, Mg, Mn, Na, Ni, P, Pb, Rb, Sc Sr, and Zn) in different types of milk samples. The ENAA was required for the determination of iodine, AAS for Cu, Ni and Pb and the rest of the elements were measured by k 0 -INAA. Thirteen elements (Br, Ca, Cl, Cs, Cu, Fe, K, Mg, Na, P, Rb, Sr and Zn) were identified in all milk samples. Ni was detected in eleven and Pb in two samples. Concentrations of most of the elements were within the ranges of the world reported data. The data was further explored by principal component analysis to find relationships between samples and elements. (orig.)

  6. Determinação de As em amostras orgânicas de interesse ambiental por espectrometria de absorção atômica com atomização eletrotérmica após combustão em bomba de O2 Determination of As in environmental organic samples by atomic absorption spectrometry with electrothermal atomization after O2 bomb combustion

    Directory of Open Access Journals (Sweden)

    Vera Maria da Costa Dias

    2003-10-01

    Full Text Available The toxicity of the major As species present in the environment justifies the effort for quantifying the element in environmental organic samples, which can vary from animal and vegetal tissues to coal and industrial residues. This paper comments about the applicability of the O2 bomb digestion, as a general procedure for all environmental organic materials. A rapid and straightforward method is suggested, which consists in burning the sample in the bomb at high O2 pressure, dissolving the vapours in diluted HNO3 and determining As in the resulting solution by atomic absorption spectrometry with electrothermal atomization. The method was applied to certified materials and plant samples.

  7. On the atomic structure of liquid Ni-Si alloys: a neutron diffraction study

    Science.gov (United States)

    Gruner, S.; Marczinke, J.; Hennet, L.; Hoyer, W.; Cuello, G. J.

    2009-09-01

    The atomic structure of the liquid NiSi and NiSi2 alloys is investigated by means of neutron diffraction experiments with isotopic substitution. From experimental data-sets obtained using four Ni isotopes, partial structure factors and pair correlation functions are obtained by applying a reverse Monte Carlo modelling approach. Both alloys were found to exhibit a strong tendency to hetero-coordination within the first coordination shell. In particular, covalent Si-Si bonds with somewhat greater distances seem to influence the structure of the liquid NiSi alloy.

  8. The application of neutron reflectometry and atomic force microscopy in the study of corrosion inhibitor films

    International Nuclear Information System (INIS)

    John, Douglas; Blom, Annabelle; Bailey, Stuart; Nelson, Andrew; Schulz, Jamie; De Marco, Roland; Kinsella, Brian

    2006-01-01

    Corrosion inhibitor molecules function by adsorbing to a steel surface and thus prevent oxidation of the metal. The interfacial structures formed by a range of corrosion inhibitor molecules have been investigated by in situ measurements based on atomic force microscopy and neutron reflectometry. Inhibitors investigated include molecules cetyl pyridinium chloride (CPC), dodecyl pyridinium chloride (DPC), 1-hydroxyethyl-2-oleic imidazoline (OHEI) and cetyl dimethyl benzyl ammonium chloride (CDMBAC). This has shown that the inhibitor molecules adsorb onto a surface in micellar structures. Corrosion measurements confirmed that maximum inhibition efficiency coincides with the solution critical micelle concentration

  9. Neutron diffraction studies of atomic structures of amorphous Fe-Ge and Ni-Ge alloys

    International Nuclear Information System (INIS)

    Yamada, Kazuyoshi; Endoh, Yasuo; Ishikawa, Yoshikazu; Watanabe, Noboru.

    1980-01-01

    The structures of Ge rich amorphous Fe-Ge and Ni-Ge alloys were studied by pulsed neutron total scattering. The partial structure factors of S sub(GeGe)(Q), S sub(NiGe)(Q) and S sub(NiNi)(Q) were determined successfully by using Ni 60 isotope for the Ni-Ge alloys. The Ge atoms in the 10 at% Ni-Ge amorphous alloy were found to construct a similar atomic structure as that of the amorphous Ge, while the intermediate short range order configuration between the tetrahedral random network (TRN) and the dense random packing (DRP) structure was found for the 30 at% Ni-Ge alloy. The Ge-Ge pair correlation for this intermediate short range order could well be reproduced by the modified Ge II microcrystalline model. (author)

  10. Sensitivity of primary knock-on atom spectra and displacement per atom cross sections to different secondary neutron energy and angular distributions and ''in-group'' weighting schemes

    International Nuclear Information System (INIS)

    Gabriel, T.A.; Bishop, B.L.

    1978-01-01

    The sensitivity of primary knock-on atom (PKA) spectra and displacement per atom (DPA) cross sections to different secondary neutron energy and angular distributions and ''in-group'' weighting schemes is investigated. It is shown that the sensitivity of the PKA spectra and DPA cross sections for the (n,n' unresolved) and (n,2n) reactions in Fe to different angular distributions and the same secondary neutron spectrum is reasonably large (approximately 15%), whereas the sensitivity of these quantities to grossly different secondary neutron spectra and the same angular distribution is unexpectedly small. It is also shown that for Al the sensitivity of damage energy cross sections to different ''in-group'' weighting schemes is, for the most part, small

  11. Increased frequency of CD4{sup -}8{sup -}T cells bearing T-cell receptor {alpha}{beta} chains in peripheral blood of atomic bomb survivors exposed to high doses

    Energy Technology Data Exchange (ETDEWEB)

    Yoichiro Kusunoki; Seishi Kyoizumi; Yuko Hirai; Shoichiro Fujita; Mitoshi Akiyama [Radiation Effects Research Foundation, Hiroshima (Japan)

    1994-07-01

    A rare T-cell subpopulation, CD4{sup -z}8{sup -}{alpha}{beta} cells, may be differentiated through a pathway (or pathways) different from the pathway(s) of conventional CD4+ or CD8+ cells. In the present study, the frequencies of CD4{sup -}8{sup -} T cells in peripheral-blood {alpha}{beta} T cells in 409 atomic bomb survivors were determined to investigate late effects of radiation on the composition of human T-cell subpopulations. The frequency of CD4{sup -}8{sup -}{alpha}{beta} T-cell decreased significantly with the subject`s age and was higher in females than males. A significant increase in the frequency was found in the survivors exposed to more than 1.5Gy, suggesting that the previous radiation exposure altered differentiation and development of T cells. 25 refs., 4 figs., 3 tabs.

  12. Neutron diffraction study of ordering of atoms and antiphase domains in titanium carbohydrides

    International Nuclear Information System (INIS)

    Khidirov, I.; Mirzaev, B.B.; Sultanova, S.Kh.; Mukhtarova, N.N.; Getmanskiy, V.V.

    2004-01-01

    Full text: As a result of neutron diffraction study of titanium carbon hydrides of a number of compositions at the lower limit of the carbon homogeneity region (TiC 0.47 H 0.22 , TiC 0.47 H 0.19 , TiC 0.47 H 0.07 , TiC 0.50 H 0.21 ) after by heat treatment using special regime for preventing exit of hydrogen out of the lattice, five temperature ranges of temperature of structural changes are found out. 1. T ≥ 1200 o C, at which titanium carbon hydrides have disordered cubic structure, is described within the framework of sp. gr. Fd3m, where the carbon atoms occupy octahedral interstices and the hydrogen atoms - tetrahedral ones. 2. 1000 o C ≤ T ≤ 1100 o C: it is still observed the disordered cubic structure in which the hydrogen atoms statistically are arranged on both octahedral and tetrahedral interstices. 3. 800 0 C ≤ T ≤ 1000 o C: formation of long-range order is observed. Crystal structure of the ordered phase is described within the framework of sp. gr. Fd3m, where the carbon atoms occupy one type of octahedral interstices 16 (c) and the hydrogen atoms - the other type of octahedral interstices 16 (d). 4. 600 o C ≤ T ≤ 800 o C: the decay of ordered cubic phase with segregation of α-Ti is observed. 5. T≤ 475 o C: the formation of metastable ordered cubic phase with the formation of periodic antiphase domains is observed, at these temperatures process of the decay is hindered. It should be noted that the formation of ordered periodic antiphase domains (long-period structure) in the interstitial phase is found for the first time. This work was supported by the Center of Science and Technology of the Republic of Uzbekistan (contract No F-2.1.2)

  13. Neutron diffraction study of ordering of atoms and antiphase domains in titanium carbohydrides

    International Nuclear Information System (INIS)

    Khidirov, I.; Mirzaev, B.B.; Sultanova, S.Kh.; Mukhtarova, N.N.; Getmanskiy, V.V.

    2004-01-01

    As a result of neutron diffraction study of titanium carbon hydrides of a number of compositions at the lower limit of the carbon homogeneity region (TiC 0.47 H 0.22 , TiC 0.47 H 0.19 , TiC 0.47 H 0.07 , TiC 0.50 H 0.21 ) after by heat treatment using special regime for preventing exit of hydrogen out of the lattice, five temperature ranges of temperature of structural changes are found out. 1. T ≥ 1200 o C, at which titanium carbon hydrides have disordered cubic structure, is described within the framework of sp. gr. Fd3m, where the carbon atoms occupy octahedral interstices and the hydrogen atoms - tetrahedral ones. 2. 1000 o C ≤ T ≤ 1100 o C: it is still observed the disordered cubic structure in which the hydrogen atoms statistically are arranged on both octahedral and tetrahedral interstices. 3. 800 0 C ≤ T ≤ 1000 o C: formation of long-range order is observed. Crystal structure of the ordered phase is described within the framework of sp. gr. Fd3m, where the carbon atoms occupy one type of octahedral interstices 16 (c) and the hydrogen atoms - the other type of octahedral interstices 16 (d). 4. 600 o C ≤ T ≤ 800 o C: the decay of ordered cubic phase with segregation of α-Ti is observed. 5. T≤ 475 o C: the formation of metastable ordered cubic phase with the formation of periodic antiphase domains is observed, at these temperatures process of the decay is hindered. It should be noted that the formation of ordered periodic antiphase domains (long-period structure) in the interstitial phase is found for the first time. This work was supported by the Center of Science and Technology of the Republic of Uzbekistan (contract No F-2.1.2). (author)

  14. Bomb apologetics: Farm Hall, August 1945

    Energy Technology Data Exchange (ETDEWEB)

    Bernstein, J. [Professor of Physics at Stevens Institute of Technology in Hoboken New Jersey (United States); Cassidy, D. [Professor at Hofstra University, in Hempstead, New York (United States)

    1995-08-01

    On hearing the news from Hiroshima, the incredulous internees came up with a self-serving story to explain their failures in nucleus research: To keep Hitler from winning, they had deliberately not developed the atomic bomb. {copyright} 1995 {ital American} {ital Institute} {ital of} {ital Physics}.

  15. Bomb apologetics: Farm Hall, August 1945

    International Nuclear Information System (INIS)

    Bernstein, J.; Cassidy, D.

    1995-01-01

    On hearing the news from Hiroshima, the incredulous internees came up with a self-serving story to explain their failures in nucleus research: To keep Hitler from winning, they had deliberately not developed the atomic bomb. copyright 1995 American Institute of Physics

  16. Effects of A-bomb radiation on the human body

    International Nuclear Information System (INIS)

    Shigematsu, Itsuzo; Akiyama, Mitoshi; Sasaki, Hideo; Ito, Chikato; Kamada, Nanao

    1992-01-01

    This publication consists of contributions by 39 authors in Hiroshima who are active in the forefront of research, diagnosis and treatment concerning atomic bomb survivors. Following a brief description on the damage of the atomic bomb, the subjects of malignant tumors, endocrine and metabolic diseases, ocular lesions, dermatologic effects, prenatal exposure, chromosomal aberrations, mutations, sensitivity to radiation, immune function, genetic effects and other effects of radiation are described. All of the 45 chapters are indexed individually. (J.P.N.)

  17. Study of atmospheric aerosols in Zaire by instrumental neutron activation analysis, atomic absorption spectrophotometry and ion-exchange chromatography

    International Nuclear Information System (INIS)

    Tshiashala, M.D.; Lumu, B.M.; Matamba, K.; Ronneau, C.

    1992-01-01

    Instrumental neutron activation analysis and atomic absorption spectroscopy were applied to the determination of trace element abundances in airborne particulate matter collected throughout Kinshasa, Zaire. Statistical treatment of the resulting data was used to assess the variations between sites and to identify the sources of the pollutants. 10 refs, 5 tabs

  18. Sensitivity of parity-violating Ae-vector, e') A scattering and atomic parity nonconservation to neutron distributions in nuclei

    CERN Document Server

    Pollock, S J

    2000-01-01

    Parity-violating electron scattering (PVES) could provide a unique means to determine spatial neutron distributions and their moments in heavy nuclei. Knowledge of the neutron distribution is of fundamental interest for nuclear structure models, and the first moment is of special interest for atomic parity experiments. We have examined what could be learned from a hypothetical measurement of the parity-violating asymmetry in elastic electron scattering on barium and lead nuclei (both spin-0 and N not =Z). We find that a single measurement of this quantity could determine the rms neutron radius to within a couple of percent, to be compared with the 5-10% existing uncertainties. We also compute the quantitative connection to atomic parity nonconservation, and the resulting limits on possible low energy Standard Model tests which could be achieved.

  19. A-bomb radiation effects digest

    International Nuclear Information System (INIS)

    Shigematsu, Itsuzo; Akiyama, Mitoshi; Sasaki, Hideo; Ito, Chikako; Kamada, Nanao.

    1993-01-01

    This publication is the digest of the book 'Genbaku Hoshasen no Jintai Eikyo (Effects of A-bomb Radiation on the Human Body)' (365p.), published in Japanese by Hiroshima International Council for Medical Care of the Radiation-Exposed. Following a brief description on the damage of the atomic bomb, the subjects of malignant tumors, endocrine and metabolic deseases, ocular lesions, dermatologic effects, prenatal exposure, chromosoal aberrations, mutations, sensitivity to radiation, immune function, genetic effects and other effects of radiation are summarized. (J.P.N.)

  20. Effect of the defect-phosphorus atom complex interaction on the formation of the properties of neutron-doped silicon

    International Nuclear Information System (INIS)

    Kolesnik, L.I.; Lejferov, B.M.

    1984-01-01

    Radiation-induced defect annealing and changes in the concentration of substituting phosphorus atoms in silicon irradiated with different neutron doses have been studied by the low-temperature photoluminescence (PL) method at 4 K. Based on the PL spectrum character dependence on the fast-to-thermal neutron ration in a flux, series of lines and bands associated with the preferential formation of radiation-induced defects (within the 1.100 eV energy range) and with the presence of phosphorus impurity (1.15-1.12 eV) are identified. Some peculiarities are studied of the stage-by-stage annealing (250-500, 430-600, 600-800 deg C) of recombination-active centers (RAC) determining the radiation in the mentioned spectrum region. The relation between the RAC variations within the 1.12-1.15 eV range and the substituting phosphorus atom concentration in the 400-500 deg C temperature range is found. Activation energy of the substituting phosphorus atom concentration variation is estimated (approximately 0.5 eV). It is shown that the formation of defect-phosphorus complexes plays an important role in the formation of neutron-doped silicon properties, the presence of fast neutron in a flux being most importants

  1. Atomic force microscopic neutron-induced alpha-autoradiography for boron imaging in detailed cellular histology

    International Nuclear Information System (INIS)

    Amemiya, K.; Takahashi, H.; Fujita, K.; Nakazawa, M.; Yanagie, H.; Eriguchi, M.; Nakagawa, Y.; Sakurai, Y.

    2006-01-01

    The information on subcellular microdistribution of 10 B compounds a cell is significant to evaluate the efficacy of boron neutron capture therapy (BNCT) because the damage brought by the released alpha/lithium particles is highly localized along their path, and radiation sensitivity is quite different among each cell organelles. In neutron-induced alpha-autoradiography (NIAR) technique, 10 B can be measured as tracks for the energetic charged particles from 10 B(n, alpha) 7 Li reactions in solid state track detectors. To perform the NIAR at intracellular structure level for research of 10 B uptake and/or microdosimetry in BNCT, we have developed high-resolution NIAR method with an atomic force microscope (AFM). AFM has been used for analyses of biological specimens such as proteins, DNAs and surface of living cells have, however, intracellular detailed histology of cells has been hardly resolved with AFM since flat surface of sectioned tissue has quite less topographical contrast among each organelle. In our new sample preparation method using UV processing, materials that absorb UV in a semi-thin section are selectively eroded and vaporized by UV exposure, and then fine relief for cellular organelles such as mitochondria, endoplasmic reticulum, filament structure and so on reveals on flat surface of the section, which can be observed with an AFM. The imaging resolution was comparable to TEM imaging of cells. This new method provides fast and cost-effective observation of histological sections with an AFM. Combining this method with NIAR technique, intracellular boron mapping would be possible. (author)

  2. Neutron scattering facilities at China Institute of Atomic Energy. Present and future situations

    Energy Technology Data Exchange (ETDEWEB)

    Ye, C.T.; Gou, C.; Yang, T.H. [China Institute of Atomic Energy, Beijing (China)

    2001-03-01

    The 15 MW Heavy Water Research Reactor (HWRR) at CIAE in Beijing is the only neutron source available for neutron scattering experiments in China at present. So far totally 5 neutron scattering spectrometers are installed at 4 beam tubes. A 60 MW new research reactor, China Advanced Research Reactor (CARR), now is being built at CIAE to meet the increasing demand of neutron scattering research in China. A brief description of HWRR, the presently existing neutron scattering equipments at HWRP, CARR, and the neutron scattering facilities to be installed at CARR are presented. (J.P.N.)

  3. Determination of tin in biological reference materials by atomic absorption spectrophotometry and neutron activation analysis

    International Nuclear Information System (INIS)

    Chiba, M.; Iyengar, V.; Gills, T.

    1991-01-01

    Because of a lack of reliable analytical techniques for the determination of tin in biological materials, there have been no reference materials certified for this element. However, the authors' experience has shown that it is feasible to use both atomic absorption and nuclear activation techniques at least for selected matrices. Therefore, an investigation was undertaken to determine tin in several biological materials such as non-fat milk powder (NBS-SRM-1549), citrus leaves (NBS-SRM-1572), total diet (NIST-SRM-1548), mixed diet (NBS-RM-8431), and USDIET-I by atomic absorption spectrophotometry (AAS) and neutron activation analysis (NAA). AAS-ashed samples were extracted with MIBK and assayed using a Perkin Elmer model 5000 apparatus. NAA was carried out by irradiating the samples at the NIST reactor in the RT-4 facility and counting with the help of a Ge(Li) detector connected to a multichannel analyzer. The concentration of tin measured by both AAS and NAA agree well for USDIET-I, total diet, citrus leaves and non-fat milk powder (the concentration ranges for tin in these matrices were from 0.0025 to 3.8 micro g/g). However, in the case of mixed diet (RM-8431), the mean values found were 47 ± 5.6 (n = 19) by AAS and 55.5 ± 2.5 (n = 6) by INAA. Since RM-8431 is not certified it is difficult to draw conclusions. For apple and peach leaves, a distillation step was required. The results were apple leaves 0.085 ± 0.015 (n = 10) by AAS and < 0.2 (n = 3) by RNAA; for peach leaves 0.077 ± 0.02 (n = 9) by AAS and < 0.1 (n = 3) by RNAA. All concentrations are expressed in micro g/g dry weight

  4. Pressure/temperature fluid cell apparatus for the neutron powder diffractometer instrument: Probing atomic structure in situ

    International Nuclear Information System (INIS)

    Wang, Hsiu-Wen; Fanelli, Victor R.; Reiche, Helmut M.; Larson, Eric; Taylor, Mark A.; Siewenie, Joan; Xu, Hongwu; Zhu, Jinlong; Page, Katharine

    2014-01-01

    This contribution describes a new local structure compatible gas/liquid cell apparatus for probing disordered materials at high pressures and variable temperatures in the Neutron Powder Diffraction instrument at the Lujan Neutron Scattering Center, Los Alamos National Laboratory. The new sample environment offers choices for sample canister thickness and canister material type. Finite element modeling is utilized to establish maximum allowable working pressures of 414 MPa at 15 K and 121 MPa at 600 K. High quality atomic pair distribution function data extraction and modeling have been demonstrated for a calibration standard (Si powder) and for supercritical and subcritical CO 2 measurements. The new sample environment was designed to specifically target experimental studies of the local atomic structures involved in geologic CO 2 sequestration, but will be equally applicable to a wide variety of energy applications, including sorption of fluids on nano/meso-porous solids, clathrate hydrate formation, catalysis, carbon capture, and H 2 and natural gas uptake/storage

  5. Pressure/temperature fluid cell apparatus for the neutron powder diffractometer instrument: Probing atomic structure in situ

    Science.gov (United States)

    Wang, Hsiu-Wen; Fanelli, Victor R.; Reiche, Helmut M.; Larson, Eric; Taylor, Mark A.; Xu, Hongwu; Zhu, Jinlong; Siewenie, Joan; Page, Katharine

    2014-12-01

    This contribution describes a new local structure compatible gas/liquid cell apparatus for probing disordered materials at high pressures and variable temperatures in the Neutron Powder Diffraction instrument at the Lujan Neutron Scattering Center, Los Alamos National Laboratory. The new sample environment offers choices for sample canister thickness and canister material type. Finite element modeling is utilized to establish maximum allowable working pressures of 414 MPa at 15 K and 121 MPa at 600 K. High quality atomic pair distribution function data extraction and modeling have been demonstrated for a calibration standard (Si powder) and for supercritical and subcritical CO2 measurements. The new sample environment was designed to specifically target experimental studies of the local atomic structures involved in geologic CO2 sequestration, but will be equally applicable to a wide variety of energy applications, including sorption of fluids on nano/meso-porous solids, clathrate hydrate formation, catalysis, carbon capture, and H2 and natural gas uptake/storage.

  6. Pressure/temperature fluid cell apparatus for the neutron powder diffractometer instrument: probing atomic structure in situ.

    Science.gov (United States)

    Wang, Hsiu-Wen; Fanelli, Victor R; Reiche, Helmut M; Larson, Eric; Taylor, Mark A; Xu, Hongwu; Zhu, Jinlong; Siewenie, Joan; Page, Katharine

    2014-12-01

    This contribution describes a new local structure compatible gas/liquid cell apparatus for probing disordered materials at high pressures and variable temperatures in the Neutron Powder Diffraction instrument at the Lujan Neutron Scattering Center, Los Alamos National Laboratory. The new sample environment offers choices for sample canister thickness and canister material type. Finite element modeling is utilized to establish maximum allowable working pressures of 414 MPa at 15 K and 121 MPa at 600 K. High quality atomic pair distribution function data extraction and modeling have been demonstrated for a calibration standard (Si powder) and for supercritical and subcritical CO2 measurements. The new sample environment was designed to specifically target experimental studies of the local atomic structures involved in geologic CO2 sequestration, but will be equally applicable to a wide variety of energy applications, including sorption of fluids on nano/meso-porous solids, clathrate hydrate formation, catalysis, carbon capture, and H2 and natural gas uptake/storage.

  7. Study of the Neutron Deficient Pb and Bi Isotopes by Simultaneous Atomic- and Nuclear-Spectroscopy

    CERN Multimedia

    Kessler, T

    2002-01-01

    We propose to study systematically nuclear properties of the neutron deficient lead $^{183-189}$Pb, $^{191g}$Pb, $^{193g}$Pb and bismuth isotopes $^{188-200}$Bi by atomic spectroscopy with the ISOLDE resonance ionisation laser ion source (RILIS) combined with simultaneous nuclear spectroscopy at the detection set-up. The main focus is the determination of the mean square charge radii of $^{183-190}$Pb and $^{188-193}$Bi from which the influence of low-lying intruder states should become obvious. Also the nuclear spin and magnetic moments of ground-states and long-lived isomers will be determined unambiguously through evaluation of the hyperfine structure, and new isomers could be discovered. The decay properties of these nuclei can be measured by $\\alpha$-$\\gamma$ and $\\beta$-$\\gamma$ spectroscopy. With this data at hand, possible shape transitions around mid-shell at N$\\sim$104 will be studied. This data is crucial for the direct test of nuclear theory in the context of intruder state influence (e.g. energy ...

  8. Elemental analysis using instrumental neutron activation analysis and inductively coupled plasma atomic emission spectrometry: a comparative study

    International Nuclear Information System (INIS)

    Chung, Yong Sam; Choi, Kwang Soon; Moon, Jong Hwa; Kim, Sun Ha; Lim, Jong Myoung; Kim, Young Jin; Quraishi, Shamshad Begum

    2003-05-01

    Elemental analyses for certified reference materials were carried out using instrumental neutron activation analysis and inductively coupled plasma-atomic emission spectrometry. Five Certified Reference Materials (CRM) were selected for the study on comparative analysis of environmental samples. The CRM are Soil (NIST SRM 2709), Coal fly ash (NIST SRM 1633a), urban dust (NIST SRM 1649a) and air particulate on filter media (NIST SRM 2783 and human hair (GBW 09101)

  9. Details of Nazis' A-Bomb program surface

    CERN Multimedia

    Glanz, J

    2002-01-01

    Werner Heisenberg, leader of the Nazi atomic bomb program, revealed the projects existence to Niels Bohr in a meeting in Copenhagen in 1941. But contrary to several historical accounts of the meeting, Heisenberg never expressed moral qualms about building a bomb for Hitler nor hinted that he might be willing to sabotage the project, according to secret documents cited in a London newspaper yesterday (2 pages).

  10. Hitlers' bomb. The secret story of Germanys' nuclear weapon tests

    International Nuclear Information System (INIS)

    Karlsch, R.

    2005-01-01

    This book reveals a sensation: Under supervision of the SS German scientists tested 1944/45 nuclear bombs on Ruegen and in Thuringia. During this period several hundred prisoners of war and prisoners died. Besides proofs for nuclear weapon testing the author also found a draft for a patent on plutonium bombs and discovered the first functioning German atom reactor in the environs of Berlin. (GL) [de

  11. Imaginary Savior: the image of the nuclear bomb in Korea, 1945-1960.

    Science.gov (United States)

    Kim, Dong-Won

    2009-01-01

    Two atomic bombs dropped on Hiroshima and Nagasaki in August 1945 brought the unexpected liberation of Korea from the 35-year Japanese occupation. Koreans therefore had a very favorable and positive image of the nuclear bomb and nuclear energy from the beginning. The image of the nuclear bomb as "savior" was strengthened during the Korean War when the United States openly mentioned the possible use of the nuclear bomb against North Korean and Chinese military. After the end of the Korean War in July 1953 South Koreans strongly supported the development of the nuclear bomb in order to deter another North Korean invasion. When the US government provided South Korea with a research nuclear reactor in the late 1950s, most South Koreans hailed it as the first step to developing their own nuclear bomb. This paper will analyze how and why the savior image of the nuclear bomb originated and spread in Korea during the 1950s.

  12. Biologically based analysis of lung cancer incidence in a large Canadian occupational cohort with low-LET low-dose radiation exposure, and comparison with Japanese atomic bomb survivors

    International Nuclear Information System (INIS)

    Hazelton, W.D.; Curtis, S.B.; Moolgavkar, S.H.; Hutchinson, F.; Krewski, D.

    2003-01-01

    Lung cancer incidence is analyzed in a large Canadian National Dose Registry (CNDR) cohort with individual annual dosimetry for low-dose occupational exposure to gamma and tritium radiation using several types of multistage models. The primary analysis utilizes the two-stage clonal expansion model (TSCE), with sensitivity analyses using extensions of this model incorporating additional stages. Characteristic and distinct temporal patterns of risk are found for dose-response affecting early, middle, or late stages of carcinogenesis, e.g. initiation with one or more stages, clonal expansion, or malignant conversion. Fixed lag or lag distributions are used to model time from first malignant cell to incidence. Background rates are analyzed by gender, job classification and birth cohort. Lacking individual smoking data, surrogate doses based on US annual per capita cigarette consumption appear to account for much of the birth cohort effect. Males, with mean cumulative exposure for gamma and tritium of 11.5 mSv and 322 incident lung cancer cases have a significant dose-response with 33 cases attributable to radiation. Female dose-response, with mean cumulative exposure of 1.7 mSv and 78 incident cases, appears similar but is not statistically significant. Findings for males include an inverse-dose-rate effect (increased risk with protraction of a given dose) and dose-response effects on initiation, promotion and malignant conversion, although the effect on initiation is not statistically significant. The excess relative risk (ERR) and excess absolute risk (EAR) depend on age at exposure, duration, dose, and age at follow-up. The ERR increases with dose, tapering off at higher doses, making a plot of ERR against dose concave-downward, similar to apparent low-dose results seen below 1 Sv for solid tumor mortality of atomic bomb survivors. The concave-downward trend of ERR and the inverse-dose-rate effect are both counter to prevailing beliefs about effects of low

  13. The early development of neutron diffraction: science in the wings of the Manhattan Project.

    Science.gov (United States)

    Mason, T E; Gawne, T J; Nagler, S E; Nestor, M B; Carpenter, J M

    2013-01-01

    Although neutron diffraction was first observed using radioactive decay sources shortly after the discovery of the neutron, it was only with the availability of higher intensity neutron beams from the first nuclear reactors, constructed as part of the Manhattan Project, that systematic investigation of Bragg scattering became possible. Remarkably, at a time when the war effort was singularly focused on the development of the atomic bomb, groups working at Oak Ridge and Chicago carried out key measurements and recognized the future utility of neutron diffraction quite independent of its contributions to the measurement of nuclear cross sections. Ernest O. Wollan, Lyle B. Borst and Walter H. Zinn were all able to observe neutron diffraction in 1944 using the X-10 graphite reactor and the CP-3 heavy water reactor. Subsequent work by Wollan and Clifford G. Shull, who joined Wollan's group at Oak Ridge in 1946, laid the foundations for widespread application of neutron diffraction as an important research tool.

  14. (In)security factor atomic bomb. An analysis of the crisis with the Iranian nuclear program; (Un-)Sicherheitsfaktor Atombombe. Eine Analyse der Krise um das iranische Nuklearprogramm

    Energy Technology Data Exchange (ETDEWEB)

    Bock, Andreas [Augsburg Univ. (Germany). Lehrstuhl fuer Friedens- und Konfliktforschung

    2012-04-15

    Iran is a rational actor in the international politics that decides on the basis of the perception of threat. Iran's security situation is comparable with that of Israel with the rational consequence to rely on the atomic program with respect to deterrence and self-defense. The solution of the Iran crisis is basically dependent on a change of the perception of threat. A military act against the Iranian nuclear facilities would be counterproductive, would only slowing down the program but not prevent further activities. In fact a military act would enhance the perception of threat. For the analysis of the Iran crises the author used the Cuba crisis as blueprint, were mislead perceptions were responsible for the escalation.

  15. Physics for all, who want to join in conversation. On atomic power, dirty bombs, space research, solar energy, and the global heating

    International Nuclear Information System (INIS)

    Muller, Richard A.

    2009-01-01

    Which dangers contains the global heating really? What can happen at an attack on a atomic power plant?. Which chances offer renewable energies? Questions which are put daily in the pursuing of news - but to which we have only seldomly answers ready, because basic physical knowledge is absent. But it must not even be the great world policy. Already at the decision wether solar cells shall be mounted on the roof or punted on geothermal heat physics are not unimportant. More often than we think it are natural sciences, which yield the foundations for important decisions. Richard A. Muller explains simply and illustratively, how physics determines our life. Thereby he removes prejudices and mediates quite surprising insights

  16. Atoms

    International Nuclear Information System (INIS)

    Fuchs, Alain; Villani, Cedric; Guthleben, Denis; Leduc, Michele; Brenner, Anastasios; Pouthas, Joel; Perrin, Jean

    2014-01-01

    Completed by recent contributions on various topics (atoms and the Brownian motion, the career of Jean Perrin, the evolution of atomic physics since Jean Perrin, relationship between scientific atomism and philosophical atomism), this book is a reprint of a book published at the beginning of the twentieth century in which the author addressed the relationship between atomic theory and chemistry (molecules, atoms, the Avogadro hypothesis, molecule structures, solutes, upper limits of molecular quantities), molecular agitation (molecule velocity, molecule rotation or vibration, molecular free range), the Brownian motion and emulsions (history and general features, statistical equilibrium of emulsions), the laws of the Brownian motion (Einstein's theory, experimental control), fluctuations (the theory of Smoluchowski), light and quanta (black body, extension of quantum theory), the electricity atom, the atom genesis and destruction (transmutations, atom counting)

  17. Simulating an Exploding Fission-Bomb Core

    Science.gov (United States)

    Reed, Cameron

    2016-03-01

    A time-dependent desktop-computer simulation of the core of an exploding fission bomb (nuclear weapon) has been developed. The simulation models a core comprising a mixture of two isotopes: a fissile one (such as U-235) and an inert one (such as U-238) that captures neutrons and removes them from circulation. The user sets the enrichment percentage and scattering and fission cross-sections of the fissile isotope, the capture cross-section of the inert isotope, the number of neutrons liberated per fission, the number of ``initiator'' neutrons, the radius of the core, and the neutron-reflection efficiency of a surrounding tamper. The simulation, which is predicated on ordinary kinematics, follows the three-dimensional motions and fates of neutrons as they travel through the core. Limitations of time and computer memory render it impossible to model a real-life core, but results of numerous runs clearly demonstrate the existence of a critical mass for a given set of parameters and the dramatic effects of enrichment and tamper efficiency on the growth (or decay) of the neutron population. The logic of the simulation will be described and results of typical runs will be presented and discussed.

  18. Air quality status in Kinshasa as determined by instrumental neutron activation analysis, atomic absorption spectrometry and ion-exchange chromatography

    International Nuclear Information System (INIS)

    Lobo, K.K.

    1991-01-01

    Three independent analytical techniques - instrumental neutron activation analysis. Atomic absorption spectrometry and ion-exchange chromatography - were applied to airborne particulate collected on filters and to atmospheric acid gases collected in carbonate buffer solutions. 20 trace elements and 7 acid gases and acid aerosols were determined. Results were compared with those observed elsewhere and showed that air pollution is low in Kinshasa and does not give rise to anxieties. The main known sources of pollutants are: vehicle exhaust and aeolian process on stripped soils. (author). 13 refs, 2 figs, 6 tabs

  19. Assessment of metal and trace element concentrations in the Cananeia estuary, Brazil, by neutron activation and atomic absorption techniques

    International Nuclear Information System (INIS)

    Amorim, E.P.; Favaro, D.I.T.; Berbel, G.B.B.; Braga, E.S.

    2008-01-01

    Twenty six bottom sediment samples were collected from the Cananeia estuary in summer and winter of 2005. Multielemental analysis was carried out by instrumental neutron activation analysis. Total mercury was determined by cold vapor atomic absorption. As, Cr, Hg and Zn concentrations were compared to the Canadian oriented values (TEL and PEL). Sample points 4 and 9 presented higher concentration for most elements and As and Cr exceeded the TEL values. Organic matter (>10%) associated with siltic and clay sediments was observed. Climatic conditions, hydrodynamic and biogeochemical processes promote differences in seasonal concentrations of elements at some points, which contribute to special distributions. (author)

  20. Evaluation of emery dust on the manufacture of abrasives by neutron activation analysis and atomic absorption spectroscopy

    International Nuclear Information System (INIS)

    Granados Correa, F.

    1992-01-01

    In this work it is presented an evaluation on the degree of contamination by emery dust in a working area where abrasives are manufactured, in a factory located in the industrial area of Toluca City by neutron activation analysis and atomic absorption spectroscopy. The samples were collected on Whatman filters and attacked with hot concentrated HCl. The elements founded were: Al, Si, V, Mg, Br, Mn, Ni, Zn, Fe, Cr, Ca and Pb. They are a risk for the health of the workers. (Author)

  1. Redesigning the rotating-bomb combustion calorimeter

    International Nuclear Information System (INIS)

    Flores, Henoc; Mentado, Juan; Amador, Patricia; Torres, Luis Alfonso; Campos, Myriam; Rojas, Aaron

    2006-01-01

    In order to obtain reliable data of the standard enthalpy of combustion of compounds containing sulfur or halogen atoms, a new calorimetric rotating-bomb system has been set up. Around a platinum lining Parr 1004 C combustion bomb, an isoperibolic calorimeter has been designed, constructed and tested. The calorimeter was calibrated by using standard benzoic acid and the resulting equivalent in energy was ε(calor)=(14321.2+/-2.4)J.K -1 . Combustion measurements using thianthrene were made in order to verify the accuracy of the device, leading to the value of Δ c u o =-(33462.9+/-5.7)J.g -1 , in agreement with the recommended one

  2. The neutron physics constants bank of the I.V. Kurchatov Institute of Atomic Energy

    International Nuclear Information System (INIS)

    Yudkevich, M.S.

    1987-01-01

    This paper describes the structure and contents of a neutron physics constants bank consisting of libraries, service programs and data preparation codes for reactor calculations. Use of the bank makes the constants fully accessible to users. (author)

  3. Our Electron, Proton and Neutron Models Predict Atom Building from Three-ring Orthogonal Interlocks of Properly Quarked Nucleons.

    Science.gov (United States)

    McLeod, Roger; McLeod, David

    2008-04-01

    We posited flatland electron loop strings from transversely vibrating neutrino strings. Loop traveling waves TWs alternately become upwardly deflecting standing waves SWs along each half-wave segment between non-vibrating node pairs. Descending SWs again revert to TWs at flatland, as far as the next two adjacent nodal pairs, where folding continues and new SWs descend, then ascend, and repetition follows. Three dimensional objects, not points, result. A broken ``linear'' electron string and its electron spring constant are compressed within stars until linear mass density is compatible with incorporation into a stable three-ring proton string. The created neutron has two down quarks and one up, but must be unstable because it lacks overpass-underpass interlocks of our proton that shared its linear charge density of two up quarks and one down quark with the electron, becoming neutral. Anu transversely aligned neutron can have one of its ``notches'' pushed into the acceptor notch of a proton, and deuterium results. Tritium may be a compatible ``catch'' of another neutron. An alpha particle follows when a second proton is forced in, creating a stable ``tic-tac-toe'' grid. Atom building proceeds routinely.

  4. Atom Probe Tomography Characterization of the Solute Distributions in a Neutron-Irradiated and Annealed Pressure Vessel Steel Weld

    Energy Technology Data Exchange (ETDEWEB)

    Miller, M.K.

    2001-01-30

    A combined atom probe tomography and atom probe field ion microscopy study has been performed on a submerged arc weld irradiated to high fluence in the Heavy-Section Steel irradiation (HSSI) fifth irradiation series (Weld 73W). The composition of this weld is Fe - 0.27 at. % Cu, 1.58% Mn, 0.57% Ni, 0.34% MO, 0.27% Cr, 0.58% Si, 0.003% V, 0.45% C, 0.009% P, and 0.009% S. The material was examined after five conditions: after a typical stress relief treatment of 40 h at 607 C, after neutron irradiation to a fluence of 2 x 10{sup 23} n m{sup {minus}2} (E > 1 MeV), and after irradiation and isothermal anneals of 0.5, 1, and 168 h at 454 C. This report describes the matrix composition and the size, composition, and number density of the ultrafine copper-enriched precipitates that formed under neutron irradiation and the change in these parameters with post-irradiation annealing treatments.

  5. Mental health status of A-bomb survivors in Nagasaki

    International Nuclear Information System (INIS)

    Nakane, Hideyuki

    2012-01-01

    The most survivors of disaster usually recover with few or no lasting effects on their mental health. However, in some portions of survivors, distress lasts long. The atomic bomb detonated to Nagasaki in August 1945 instantaneously destroyed almost all areas of the city, resulting in a total of ca. 73,884 deaths by the end of 1945 and about 74,909 injured people. Since the A-bomb survivors reached over 60 years of age, their mental health as well as physical health has become of great concern. Some studies on their mental health conditions have been carried out in Japan. I give an outline about a precedent study on mental health of the A-bomb survivors in this report. The mental health studies of the A-bomb survivors who paid attention to a being bombed experience, stigmatization, long-term outcome, recovery are necessary. The improvement of wide appropriate support system for the A-bomb survivors is expected in future. (author)

  6. Sulfur activation at the Little Boy-Comet Critical Assembly: a replica of the Hiroshima bomb

    International Nuclear Information System (INIS)

    Kerr, G.D.; Emery, J.F.; Pace, J.V. III.

    1985-04-01

    Studies have been completed on the activation of sulfur by fast neutrons from the Little Boy-Comet Critical Assembly which replicates the general features of the Hiroshima bomb. The complex effects of the bomb's design and construction on leakage of sulfur-activation neutrons were investigated both experimentally and theoretically. Our sulfur activation studies were performed as part of a larger program to provide benchmark data for testing of methods used in recent source-term calculations for the Hiroshima bomb. Source neutrons capable of activating sulfur play an important role in determining neutron doses in Hiroshima at a kilometer or more from the point of explosion. 37 refs., 5 figs., 6 tabs

  7. Influence of interstitial impurity atoms on point defect relaxation in neutron irradiated iron

    International Nuclear Information System (INIS)

    Weller, M.; Diehl, J.

    1975-01-01

    The aim of the investigation was to study the combined influence of neutron irradiation and interstitial impurities on the low temperature internal friction peaks as well as on those appearing at higher temperatures after annealing, in a more systematic manner, using irradiations at [de

  8. No blackhole and no atomic bomb

    Science.gov (United States)

    Shin, Philip

    2011-11-01

    Title: c=c(1+1=2) The light speed 1+1=2. So we count the number by step by step for one point. When we count the number by one point, we use the number written on the paper. This means this is not number, but the graph and line. The light speed is the truth in physics. I can prove it by number. 10%=0.1 As %=kg So 10kg=0.1 kg=1/10 x 1/10 kg=1/100 And 100%=1 So kg=100%/100 kg=% So 1kg=1%=1/100 E=mc^2 So cx kgx m^2/sec^2= 1kgx cx m^2/sec^2 cx 1/100x m^2/sec^2= 1/100x cx m^2/sec^2 So c/100=c/100 So c=c And c is the truth never changed. Title: By faith, no blackhole As to be, we glory to God and that is basic theology for christian. And I want to say that BE means just thinking. There is no clue of nature and no proposition to prove it. I just believe by feeling and emotion. I trust that it can be the physic really. There are only human beings and there is no idol that is different existence from human beings, that is true to be. So the nature we see is zero and we, human beings make the zero nature as from no start and no ending. No alpha and omega mean we are idol and that there is no blackhole. Blackhole means the block is existing in the nothing(as we are no alpha and no omega). So the block cannot be existence. So if there is blackhole, then there must be the wall to block me and never walk again. The big bang and evolution mean they are no alpha and no omega and existing by themselves. So they could be existence, but big bang and evolution are just logical fact to be. We need faith as God give us the direction into our spirit.

  9. Atomic structure of Mg-based metallic glass investigated with neutron diffraction, reverse Monte Carlo modeling and electron microscopy.

    Science.gov (United States)

    Babilas, Rafał; Łukowiec, Dariusz; Temleitner, Laszlo

    2017-01-01

    The structure of a multicomponent metallic glass, Mg 65 Cu 20 Y 10 Ni 5 , was investigated by the combined methods of neutron diffraction (ND), reverse Monte Carlo modeling (RMC) and high-resolution transmission electron microscopy (HRTEM). The RMC method, based on the results of ND measurements, was used to develop a realistic structure model of a quaternary alloy in a glassy state. The calculated model consists of a random packing structure of atoms in which some ordered regions can be indicated. The amorphous structure was also described by peak values of partial pair correlation functions and coordination numbers, which illustrated some types of cluster packing. The N = 9 clusters correspond to the tri-capped trigonal prisms, which are one of Bernal's canonical clusters, and atomic clusters with N = 6 and N = 12 are suitable for octahedral and icosahedral atomic configurations. The nanocrystalline character of the alloy after annealing was also studied by HRTEM. The selected HRTEM images of the nanocrystalline regions were also processed by inverse Fourier transform analysis. The high-angle annular dark-field (HAADF) technique was used to determine phase separation in the studied glass after heat treatment. The HAADF mode allows for the observation of randomly distributed, dark contrast regions of about 4-6 nm. The interplanar spacing identified for the orthorhombic Mg 2 Cu crystalline phase is similar to the value of the first coordination shell radius from the short-range order.

  10. Some investigation on trace elements content of Iranian breads using neutron activation analysis and atomic absorption spectroscopy

    International Nuclear Information System (INIS)

    Gharib, A.; Fatemi, K.; Moazezi, A.; Mahmoodzadeh, A.; Koushkestani, R.

    1988-01-01

    Since bread is consumed as a principal dietary staple by the majority of Iranian communities, actual natural portion of required protein and energy are provided via bread. Therefore, with respect to this matter, a considerable amount of needed minerals must also be met through this way. Literature survey indicates some elemental deficiencies as the result of consumption of bread in Iran. On the other hand, essentiality of these elements to human which are mostly in the range of trace amounts, makes this investigation very much important and interesting from both sides, nutritionally and instrumentally. To meet the above requirements, applications of very sensitive analytical tools are unavoidable. Hence, atomic absorption spectroscopy and neutron activation analysis both RNAA and INAA are employed. Results are controversial and constructive

  11. Neutron diffraction study of atomic ordering upon spinodal decomposition in magnetically hard Fe-Cr-Co alloys

    International Nuclear Information System (INIS)

    Vintajkin, E.Z.; Vintajkin, B.E.; Mikke, K.; Mil'charek, Ya.; Yankovska-Kiselinskaya, Ya.

    2000-01-01

    By means of neutron diffraction analysis using monocrystals one studied atomic ordering in the ferromagnetic phase formed in Fe-(24-32) at. % Cr-(14-24) at. % Co-(1.7-2.3) at. % Mo high-coercivity alloys under their decomposition during thermal treatment and its effect on the high-coercivity properties. Thermal treatment boiled down to hardening starting from 1250 Deg C, homogenization, thermomagnetic treatment and step-by-step tempering to be finished under 500 Deg C. The calculations of the component equilibrium concentrations in the phases under 500 Deg C and the measurements of the intensity of superstructure reflection demonstrated that the occurrence of the long-range order similar to B2 type occurred as concentration reached 23 at. % Co in the ferromagnetic phase at its average concentration constituting 16 at. % in the alloy [ru

  12. Inhibition of d-xylose isomerase by polyols: atomic details by joint X-ray/neutron crystallography

    Energy Technology Data Exchange (ETDEWEB)

    Kovalevsky, Andrey, E-mail: ayk@lanl.gov [Los Alamos National Laboratory, PO Box 1663, MS M888, Los Alamos, NM 87545 (United States); Hanson, B. Leif [University of Toledo, 2801 West Bancroft Street, Toledo, OH 43606 (United States); Mason, Sax A. [Institut Laue–Langevin, 6 Rue Jules Horowitz, 38042 Grenoble (France); Forsyth, V. Trevor [Institut Laue–Langevin, 6 Rue Jules Horowitz, 38042 Grenoble (France); Keele University, Staffordshire (United Kingdom); Fisher, Zoe [Los Alamos National Laboratory, PO Box 1663, MS M888, Los Alamos, NM 87545 (United States); Mustyakimov, Marat [Los Alamos National Laboratory, PO Box 1663, MS M888, Los Alamos, NM 87545 (United States); Oak Ridge National Laboratory, PO Box 2008, MS 6475, Oak Ridge, TN 37831 (United States); Blakeley, Matthew P. [Institut Laue–Langevin, 6 Rue Jules Horowitz, 38042 Grenoble (France); Keen, David A. [Harwell Science and Innovation Campus, Didcot, Oxon OX11 0QX (United Kingdom); Langan, Paul [Oak Ridge National Laboratory, PO Box 2008, MS 6475, Oak Ridge, TN 37831 (United States); Los Alamos National Laboratory, PO Box 1663, MS M888, Los Alamos, NM 87545 (United States)

    2012-09-01

    A joint X-ray/neutron structure of d-xylose isomerase in complex with the inhibitor sorbitol was determined at room temperature at an acidic pH of 5.9. Protonation of the O5 O atom of the sugar was directly observed in the nuclear density maps. Under acidic conditions sorbitol gains a water-mediated interaction with the enzyme active site, which may explain the increased potency of the inhibitor at low pH. d-Xylose isomerase (XI) converts the aldo-sugars xylose and glucose to their keto analogs xylulose and fructose, but is strongly inhibited by the polyols xylitol and sorbitol, especially at acidic pH. In order to understand the atomic details of polyol binding to the XI active site, a 2.0 Å resolution room-temperature joint X-ray/neutron structure of XI in complex with Ni{sup 2+} cofactors and sorbitol inhibitor at pH 5.9 and a room-temperature X-ray structure of XI containing Mg{sup 2+} ions and xylitol at the physiological pH of 7.7 were obtained. The protonation of oxygen O5 of the inhibitor, which was found to be deprotonated and negatively charged in previous structures of XI complexed with linear glucose and xylulose, was directly observed. The Ni{sup 2+} ions occupying the catalytic metal site (M2) were found at two locations, while Mg{sup 2+} in M2 is very mobile and has a high B factor. Under acidic conditions sorbitol gains a water-mediated interaction that connects its O1 hydroxyl to Asp257. This contact is not found in structures at basic pH. The new interaction that is formed may improve the binding of the inhibitor, providing an explanation for the increased affinity of the polyols for XI at low pH.

  13. Atomic motions in poly(vinyl methyl ether): A combined study by quasielastic neutron scattering and molecular dynamics simulations in the light of the mode coupling theory.

    Science.gov (United States)

    Capponi, S; Arbe, A; Alvarez, F; Colmenero, J; Frick, B; Embs, J P

    2009-11-28

    Quasielastic neutron scattering experiments (time-of-flight, neutron spin echo, and backscattering) on protonated poly(vinyl methyl ether) (PVME) have revealed the hydrogen dynamics above the glass-transition temperature. Fully atomistic molecular dynamics simulations properly validated with the neutron scattering results have allowed further characterization of the atomic motions accessing the correlation functions directly in real space. Deviations from Gaussian behavior are found in the high-momentum transfer range, which are compatible with the predictions of mode coupling theory (MCT). We have applied the MCT phenomenological version to the self-correlation functions of PVME atoms calculated from our simulation data, obtaining consistent results. The unusually large value found for the lambda-exponent parameter is close to that recently reported for polybutadiene and simple polymer models with intramolecular barriers.

  14. The permanent electric dipole moment of the neutron and atomic 129Xe

    International Nuclear Information System (INIS)

    Heckel, B.

    1984-01-01

    Recently the Seattle group has measured the permanent edm of atomic 129 Xe to be d /sub Xe/ = (-0.3 + or - 1.1) x 10 -26 cm. This measurement provides an improvement by a factor of 10 4 over the best previous measurement of an atomic edm. The edm of Xe is most sensitive to a T-violating electron-nucleon interaction, but can also be generated by an intrinsic electron edm or an edm of the Xe nucleus. In the second half of this presentation, each of these mechanisms will be briefly discussed and a description of the experiment will be given

  15. Sociological and socio-psycho-historical problems of A-bomb exposed twin

    International Nuclear Information System (INIS)

    Watanabe, Shoji

    1983-01-01

    The atomic bombing of Hiroshima brought many casualities on human society, and collapsed human communities. The purpose of this study is to make mainly on pairs of monozygotic twins one of whom was exposed and the other was not, or both of whom were exposed, a general socio-psycho-historical investigations through a twin control study to find whether the bombing, which can be considered to cause major environmental changes, has had any psychological effects on the individuals. Due to the limited sample of atomic bomb exposed twins, in numbers available for study, it is necessary to have an understanding for their condions of the living and identity they have developed from the numerous mental stress they suffered, and rapid socio-cultural changes they experienced, including for changes in life from birth until the atomic bombing and aftermath of the disaster. As the result of this study, by depth interview, projective psychological research and research on socio-psycho-history of exposed twin and the nonexposed before the A-bomb and aftermath of disaster, the following were obtained: a) Although at the age of four and eight they exposed, they still keep it in clear memory of the damage and suffering in the minds. b) The damage and suffereng of the family who belonged were relatively small, the effects of their psychological sufferings continued even after these thirtyseven years. c) In the aftermath of the A-bomb disaster, the psychological bond showed strengthen through crises and following social distress. d) During the long period since the bombing, those who did not experienced A-bombing, have shown high degree of support and co-operation on their familial and social role to their counterpart. e) Even though their social or medical effects of A-bombing are relatively limited, if their spouse or close relative suffer psychological stress caused by A-bomb, they too suffer from their similar experiences. (J.P.N.)

  16. Heisenberg's war. The secret history of the German bomb

    International Nuclear Information System (INIS)

    Powers, T.

    1993-01-01

    The history of Second World War Germany's 'Uranium Project', which often is referred to as the 'myth of the German atomic bomb', has been attracting the mind's of secret service men, futurologists, historians and journalists since after the end of the war it has become possible to lift the veil of secrecy. Powers book adds another one to the many investigations published since them. His approach to the piece of history starts with Heisenberg's visit to the U.S.A. in summer 1939, describes the plans of the German Heereswaffenamt pursued with the Uranium Project, and their counterpart on the side of the Allied Forces where German scientists, as immigrants in England and in the U.S.A., were doing their best to launch research for the development of an atomic bomb. The end of this 'competition' is marked by the internment of the ten German scientists and bomb specialists in Fall Hall. The leading story of the book centers on the small group of scientists around Heisenberg, who cleverly 'torpedoed' the development of the German atomic bomb in the years from 1939 until 1944. (HP) [de

  17. Assessment of Shape Memory Alloys - From Atoms To Actuators - Via In Situ Neutron Diffraction

    Science.gov (United States)

    Benafan, Othmane

    2014-01-01

    As shape memory alloys (SMAs) become an established actuator technology, it is important to identify the fundamental mechanisms responsible for their performance by understanding microstructure performance relationships from processing to final form. Yet, microstructural examination of SMAs at stress and temperature is often a challenge since structural changes occur with stress and temperature and microstructures cannot be preserved through quenching or after stress removal, as would be the case for conventional materials. One solution to this dilemma is in situ neutron diffraction, which has been applied to the investigation of SMAs and has offered a unique approach to reveal the fundamental micromechanics and microstructural aspects of bulk SMAs in a non-destructive setting. Through this technique, it is possible to directly correlate the micromechanical responses (e.g., internal residual stresses, lattice strains), microstructural evolutions (e.g., texture, defects) and phase transformation properties (e.g., phase fractions, kinetics) to the macroscopic actuator behavior. In this work, in situ neutron diffraction was systematically employed to evaluate the deformation and transformation behavior of SMAs under typical actuator conditions. Austenite and martensite phases, yield behavior, variant selection and transformation temperatures were characterized for a polycrystalline NiTi (49.9 at. Ni). As the alloy transforms under thermomechanical loading, the measured textures and lattice plane-level variations were directly related to the cyclic actuation-strain characteristics and the dimensional instability (strain ratcheting) commonly observed in this alloy. The effect of training on the shape memory characteristics of the alloy and the development of two-way shape memory effect (TWSME) were also assessed. The final conversion from a material to a useful actuator, typically termed shape setting, was also investigated in situ during constrained heatingcooling and

  18. Neutron detection in an atomic reactor core using semi-conductors

    International Nuclear Information System (INIS)

    Divoux, F.

    1968-01-01

    In this paper, the first part describes the principle of nuclear particle detection by means of semiconductor diodes and the general application of these. The second part describes fabrication of the device used to estimate thermic neutron fluxes in core of a swimming pool type reactor. The useful volume (2.9 mm thickness) is in the light water moderator, between combustible elements plates. The results, principally obtained in the core of Siloette reactor at the 'Centre d'Etudes Nucleaires de Grenoble' at low power, are mentioned in the third part. Flux maps have been set and comparison between converter's products: Bore 10, Lithium 6, Uranium 235 is made. (author) [fr

  19. Contributions to atomic microdynamics study in some liquid metals by means of soft neutrons scattering

    International Nuclear Information System (INIS)

    Rotarescu, G.

    1981-01-01

    Measurements of inelastic scattering of soft neutrons on Bi and liquid Pb, applying all the necessary corrections in view of obtaining the dYnamic structure factor S(Q,ω) were performed. The F(Q,t) function of intermediate scattering was obtained by means of the Fourier transformation of S(Q,ω). Special attention was devoted to one multiple scattering correction, especially at small scattering angles, taking into account its influence on the results. A comparison of the experimental results with three recent theoretical models has shown a good agreement in the range of intermediate and high Q values. Measurements of neutron inelastic scattering on liquid sodium at a temperature of 233 Cdeg within a momentum transfer range of 1 A -1 -1 were performed. The scattering law S(α,β) that was compared to a series of theoretical models has been determined from the experimental data. The validity of the theoretical models for different ranges of energy and momenta was thoroughly checked. S(α,β) was calculated for each type of scattering since sodium proves a mixed, coherent and incoherent scattering agent. A study on the influence of the even interaction potential upon the S(Q,ω) dynamic structure factor, the fourth order momentum ω 4 (Q) and uoon the spectral function C(Q,ω) of longitudinal current correlations was performed. For this purpose, four potentials with oscillations at great distances and a Lennard-Jones type potential were used. (author)

  20. Small angle neutron and X-ray studies of carbon structures with metal atoms

    Science.gov (United States)

    Lebedev, V. T.; Szhogina, A. A.; Bairamukov, V. Yu

    2017-05-01

    Encapsulation of metal atoms inside carbon single-wall cages or within multi-layer cells has been realized using molecular precursors and high temperature processes transforming them into desirable structures. Endohedral fullerenols Fe@C60(OH)X with 3d-metal (iron) have been studied by SANS in aqueous solutions where they form stable globular clusters with radii R C ∼ 10-12 nm and aggregation numbers N C ∼ 104. This self-assembly is a crucial feature of paramagnetic fullerenols as perspective contrast agents for Magneto-Resonance Imaging in medicine. Cellular carbon-metal structures have been created by the pyrolysis of diphthalocyanines of lanthanides and actinides. It was established that these ultra porous matrices consist of globular cells of molecular precursor size (∼ 1 nm) which are aggregated into superstructures. This provides retain of metal atoms inside matrices which may serve for safety storage of spent fuel of nuclear power plants.

  1. Small angle neutron and X-ray studies of carbon structures with metal atoms

    International Nuclear Information System (INIS)

    Lebedev, V T; Szhogina, A A; Yu Bairamukov, V

    2017-01-01

    Encapsulation of metal atoms inside carbon single-wall cages or within multi-layer cells has been realized using molecular precursors and high temperature processes transforming them into desirable structures. Endohedral fullerenols Fe@C 60 (OH) X with 3d-metal (iron) have been studied by SANS in aqueous solutions where they form stable globular clusters with radii R C ∼ 10-12 nm and aggregation numbers N C ∼ 10 4 . This self-assembly is a crucial feature of paramagnetic fullerenols as perspective contrast agents for Magneto-Resonance Imaging in medicine. Cellular carbon-metal structures have been created by the pyrolysis of diphthalocyanines of lanthanides and actinides. It was established that these ultra porous matrices consist of globular cells of molecular precursor size (∼ 1 nm) which are aggregated into superstructures. This provides retain of metal atoms inside matrices which may serve for safety storage of spent fuel of nuclear power plants. (paper)

  2. Dirty Bomb Risk and Impact

    Energy Technology Data Exchange (ETDEWEB)

    Connell, Leonard W. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2017-08-01

    We examined the relative risk and impact of a dirty bomb employing Co-60 and Cs-137, the two most common high activity source materials. We found that the risk of an area denial dirty bomb attack is greater for Cs-137 due to the form and chemistry of CsCl, the soft, powdery salt form currently in use for high activity Cs-137 sources, found in blood and research irradiators.

  3. Study of some Ayurvedic Indian medicinal plants for the essential trace elemental contents by instrumental neutron activation analysis and atomic absorption spectroscopy techniques

    International Nuclear Information System (INIS)

    Lokhande, R.S.; Singare, P.U.; Andhele, M.L.; Acharya, R.; Nair, A.G.C.; Reddy, A.V.R.

    2009-01-01

    Elemental analysis of some medicinal plants used in the Indian Ayurvedic system was performed by employing instrumental neutron activation analysis (INAA) and atomic absorption spectroscopy (AAS) techniques. The samples were irradiated with thermal neutrons in a nuclear reactor and the induced activity was counted by gamma ray spectrometry using an efficiency calibrated high resolution high purity germanium (HPGe) detector. Most of the medicinal plants were found to be rich in one or more of the elements under study. The variation in elemental concentration in same medicinal plants samples collected in summer, winter and rainy seasons was studied and the biological effects of these elements on human beings are discussed. (orig.)

  4. Neutron diffraction study of temperature dependence of atom distribution in cubic zirconium carbohydrides

    International Nuclear Information System (INIS)

    Khidirov, I.; Sultanova, S.Kh.; Mukhtarova, N.N.; Mirzaev, B.B.

    2006-01-01

    Full text: Earlier we have shown that the complex distribution of interstitial atoms takes place in the crystal lattice of cubic zirconium carbohydrides prepared by self-propagating high-temperature synthesis (SHS). One of the features of SHS-synthesis of inorganic compounds is high burning temperature and fast cooling from combustion temperature after synthesis. At that, self-hardening of the prepared product takes place, and structural state of the compound can correspond to high-temperature state. But the question about distribution of interstitial atoms over the crystal structure of cubic carbohydrides at the relatively low temperatures (T 2 C; secondly, the temperature of the order - disorder transition in zirconium carbohydrides is above 1100 deg C. It is shown that unlike in Zr-C system, in cubic zirconium carbohydrides the temperature of the order - disorder transition is much higher, and over the wide homogeneity range in the temperature interval of 1000-500 deg C the formation of trigonal ordered phase is not observed. Hence, hydrogen suppresses the formation of the ordered trigonal phase, expanding temperature range of stability of the ordered cubic phase. (author)

  5. Study of the atomic motion in methanol by slow neutron scattering

    International Nuclear Information System (INIS)

    Rodrigues, C.

    1979-01-01

    Cold neutron scattering data are reported for methyl alcohol in the liquid phase at room temperature. The quasielastic scattering was interpreted using the Larsson and Bergstedt model, that takes into account intramolecular motions and molecular diffusion. On the basis of this model, one finds for the relaxation time of the hindered rotation of the CH 3 group within the molecule a value 2,4 x 10 -12 sec. The analysis of the quasielastic scattering to the L-B model explain in a consistent way our experimental results in a range of momentum transfers of about 0.80 - 1.55A -1 . In the inelastic region some structure is observed at energy transfers of 22, 17 and 5 meV. The 17 meV energy transfer is associated with the 1→0 transition of the torsional oscillations of the methyl group. The activation energy for the above motion was calculated to be E=1.3 kcal/mol, in good agreement with the value of the barrier height for internal rotation of the CH 3 in methanol, obtained by microwave methods. (Author) [pt

  6. Bomb pulse biology

    Energy Technology Data Exchange (ETDEWEB)

    Falso, Miranda J. Sarachine [Center for Accelerator Mass Spectrometry, Mail Stop L-397, Lawrence Livermore National Laboratory, P.O. Box 808, Livermore, CA 94551 (United States); Buchholz, Bruce A., E-mail: buchholz2@llnl.gov [Center for Accelerator Mass Spectrometry, Mail Stop L-397, Lawrence Livermore National Laboratory, P.O. Box 808, Livermore, CA 94551 (United States)

    2013-01-15

    The past decade has seen an explosion in use of the {sup 14}C bomb pulse to do fundamental cell biology. Studies in the 1960s used decay counting to measure tissue turnover when the atmospheric {sup 14}C/C concentration was changing rapidly. Today bulk tissue measurements are of marginal interest since most of the carbon in the tissue resides in proteins, lipids and carbohydrates that turn over rapidly. Specific cell types with specialized functions are the focus of cell turnover investigations. Tissue samples need to be fresh or frozen. Fixed or preserved samples contain petroleum-derived carbon that has not been successfully removed. Cell or nuclear surface markers are used to sort specific cell types, typically by fluorescence-activated cell sorting (FACS). Specific biomolecules need to be isolated with high purity and accelerator mass spectrometry (AMS) measurements must accommodate samples that generally contain less than 40 {mu}g of carbon. Furthermore, all separations must not add carbon to the sample. Independent means such as UV absorbance must be used to confirm molecule purity. Approaches for separating specific proteins and DNA and combating contamination of undesired molecules are described.

  7. Atom optics

    International Nuclear Information System (INIS)

    Balykin, V. I.; Jhe, W.

    1999-01-01

    Atom optics, in analogy to neutron and electron optics, deals with the realization of as a traditional elements, such as lenes, mirrors, beam splitters and atom interferometers, as well as a new 'dissipative' elements such as a slower and a cooler, which have no analogy in an another types of optics. Atom optics made the development of atom interferometer with high sensitivity for measurement of acceleration and rotational possible. The practical interest in atom optics lies in the opportunities to create atom microprobe with atom-size resolution and minimum damage of investigated objects. (Cho, G. S.)

  8. Neutron weapons. War prevention by credible deterrence

    International Nuclear Information System (INIS)

    1981-11-01

    The neutron bomb has prompted fierce and controversial public discussions which are more emotional than based on facts. Unaware of the factual repercussions this weapon has, it has been described as the most inhumane weapon ever. By saying so, the public is wrongly informed and is made feel insecure. The following contributions made by competent authorities may be used for getting to the point, pointing out that the neutron bomb is primarily a defensive weapon. (orig.) [de

  9. Bullets, Bombs, and Bystanders: The Strategic Implications of Collateral Damage in Afghanistan

    Science.gov (United States)

    2010-05-15

    rendered another 9,200,000 homeless .34 Yet, the coup de grăce of the bombing offensive in Japan was the dropping of two atomic bombs on Hiroshima... Malaysia , Palestine, Turkey, and several others. The significant increase in these wars of liberation was a result of the declining influence of colonial...parts of Malaya and then hunt them down remorselessly.29 Ultimately, the endeavor ended in success for the British and the government of Malaysia

  10. Comparisons of atomic thermal motions for graphite at 300K based on X-ray, neutron, and phonon-spectrum data

    International Nuclear Information System (INIS)

    Chen, R.; Trucano, P.

    1978-01-01

    The mean-square amplitudes of vibration in graphite based on an X-ray charge-density analysis are 0.0032 (2) and 0.0140 (3) A 2 parallel to and perpendicular to the basal plane, respectively. Values for the parallel vibrations of 0.0031 (6) and 0.0032 A 2 were derived from temperature-dependent neutron measurements and a calculated phonon spectrum. The neutron measurements and the phonon spectrum both predict lower values [0.0090 (20) and 0.0098 A 2 ] for the out-of-plane vibrations. This small discrepancy may be caused by small changes in the core atomic scattering factors from the free-atom values or by a deficiency in the phonon-spectrum model. (Auth.)

  11. Determination of essential and toxic elements in commercial baby foods by instrumental neutron activation analysis and atomic absorption spectrometry

    International Nuclear Information System (INIS)

    Vallinoto, Priscila

    2013-01-01

    The World Health Organization recommends that infants should be breast fed exclusively for at least six months after birth. After this period, it is recommended to start introducing complementary foods, in order to meet the child's nutritional, mineral and energy needs. Commercial food products for infants form an important part of the diet for many babies. Thus, it is very important that such food contains sufficient amounts of minerals. Inadequate complementary feeding is a major cause of high rates of infant malnutrition in developing countries. In this study, essential elements: Ca, Cl, Co, Cr, Fe, K, Mg, Mn, Na, Se and Zn and toxic elements: As, Cd, Hg levels were determined in twenty seven different commercial infant food product samples by Instrumental Neutron Activation Analysis (INAA) and Atomic Absorption Spectrometry (AAS). In order to validate both methodologies the reference material: INCT MPH-2 Mixed Polish Herbs and NIST - SRM 1577b Bovine Liver by INAA and NIST - SRM 1548th Typical Diet and NIST - SRM 1547 Peach Leaves by AAS were analyzed. The twenty seven baby food samples were acquired from Sao Paulo city supermarkets and stores. Essential and toxic elements were determined. Most of the essential element concentrations obtained were lower than the World Health Organization requirements, while concentrations of toxic elements were below the tolerable upper limit. These low essential element concentrations in these samples indicate that infants should not be fed only with commercial complementary foods. (author)

  12. Metal and trace element assessment of estuary sediments from Santos, Brazil, by neutron activation and atomic absorption techniques

    International Nuclear Information System (INIS)

    Amorim, Eduardo P.; Favaro, Deborah I.T.; Berbel, Glaucia B.B.; Braga, Elisabete S.

    2007-01-01

    In order to better understanding geochemical and environmental processes and their possible changes due to anthropogenic activities trace metal analyses and their distribution in marine sediments are commonly undertaken. The present study reports result concerning the distribution of some major, trace and rare earth elements in the Santos estuarine marine sediments. Thirteen bottom sediment samples (SV0501 to SV0513) were collected in this estuary, including regions of Sao Vicente, Santos, Cubatao, Vicente de Carvalho and Santos' Bay, in the summer of 2005. Multielemental analysis was carried out by instrumental neutron activation analysis (INAA). For total mercury determination cold vapor atomic absorption technique (CV AAS) was employed. In both cases methodology validation was performed by certified reference material analyses. The results obtained for multielemental concentrations in the sediment samples were compared with NASC (North American Shale Composite) values. The concentration values obtained for As and metals Cr, Hg and Zn in the sediment samples were compared to Canadian Council of Minister of the Environment (CCME) oriented values (TEL and PEL values). In general, the samples located near the Cubatao region showed higher concentrations for all elements analyzed probably due to the high impact of industrial activities. (author)

  13. Metal and trace element assessment of estuary sediments from Santos, Brazil, by neutron activation and atomic absorption techniques

    Energy Technology Data Exchange (ETDEWEB)

    Amorim, Eduardo P.; Favaro, Deborah I.T. [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)]. E-mails: ducamorim@yahoo.com.br; defavaro@ipen.br; Berbel, Glaucia B.B.; Braga, Elisabete S. [Universidade de Sao Paulo (USP), SP (Brazil). Inst. Oceanografico. Lab. de Nutrientes, Micronutrientes e Tracos nos Oceanos - LABNUT]. E-mail: edsbraga@usp.br

    2007-07-01

    In order to better understanding geochemical and environmental processes and their possible changes due to anthropogenic activities trace metal analyses and their distribution in marine sediments are commonly undertaken. The present study reports result concerning the distribution of some major, trace and rare earth elements in the Santos estuarine marine sediments. Thirteen bottom sediment samples (SV0501 to SV0513) were collected in this estuary, including regions of Sao Vicente, Santos, Cubatao, Vicente de Carvalho and Santos' Bay, in the summer of 2005. Multielemental analysis was carried out by instrumental neutron activation analysis (INAA). For total mercury determination cold vapor atomic absorption technique (CV AAS) was employed. In both cases methodology validation was performed by certified reference material analyses. The results obtained for multielemental concentrations in the sediment samples were compared with NASC (North American Shale Composite) values. The concentration values obtained for As and metals Cr, Hg and Zn in the sediment samples were compared to Canadian Council of Minister of the Environment (CCME) oriented values (TEL and PEL values). In general, the samples located near the Cubatao region showed higher concentrations for all elements analyzed probably due to the high impact of industrial activities. (author)

  14. Advances in radiation-hydrodynamics and atomic physics simulation for current and new neutron-less targets

    International Nuclear Information System (INIS)

    Velarde, G.; Minguez, E.; Bravo, E.

    2003-01-01

    We present advances in advanced fusion cycles, atomic physics and radiation hydrodynamics. With ARWEN code we analyze a target design for ICF based on jet production. ARWEN is 2D Adaptive Mesh Refinement fluid dynamic and multigroup radiation transport. We are designing, by using also ARWEN, a target for laboratory simulation of astrophysical phenomena. We feature an experimental device to reproduce collisions of two shock waves, scaled to roughly represent cosmic supernova remnants. Opacity calculations are obtained with ANALOP code, which uses parametric potentials fitting to self-consistent potentials. It includes temperature and density effects by linearized Debye-Hueckel and it treats excited configurations and H+He-like lines. Advanced fusion cycles, as the a neutronic proton-boron 11 reaction, require very high ignition temperatures. Plasma conditions for a fusion-burning wave to propagate at such temperatures are rather extreme and complex, because of the overlapping effects of the main energy transport mechanisms. Calculations on the most appropriate ICF regimes for this purpose are presented. (author)

  15. Neutron diffraction determination of mean-square atomic displacements in InAs and GaSb

    International Nuclear Information System (INIS)

    Tibballs, J.E.; Feteris, S.M.; Barnea, Z.

    1981-01-01

    Integrated intensities for Bragg reflection of neutrons from single crystals of the III-V compounds InAs and GaSb have been measured at room temperature. The data were collected at two wave-lengths, 0.947 and 1.241 A, in order to establish the adequacy of a correction for moderate to severe anisotropic extinction. Data were also obtained for InAs at four temperatures from 408 to 933 K. Corrections for thermal diffuse scattering were applied. The results were analysed in the one-particle potential perturbation approximation with terms to fourth order in the atomic displacements u(u 1 , u 2 , u 3 ). At 296 K, the mean-square components usub(s) 2 determined were: In, 0.0116(2) A 2 ; As, 0.0102(1) A 2 ; and Ga, 0.0120(3)A 2 ; Sb, 0.0107(3)A 2 . The third-order coefficients for InAs are comparable with those for Si and Ge, while those for GaSb are comparable with those for zinc chalcogenides. Below 400 K, the mean-square displacements in InAs decrease faster than predicted by the present perturbation approach

  16. BombCAD - A new tool for bomb defense in nuclear facilities

    International Nuclear Information System (INIS)

    Massa, D.J.; Howard, J.W.; Sturm, S.R.

    1988-01-01

    This paper describes a new tool for analysis of the specific vulnerability of diverse facilites to bomb attack and for computer-aided-design (CAD) of siting, screening and hardening/softening aspects of comprehensive bomb defense programs. BombCAD combines the extensive architectural and engineering data base and graphics capabilities of modern architectural CAD systems with the bomb effects computational capability of the ''SECUREPLAN'' BOMB UTILITY. BombCAD permits architects/engineers, security professionals and facility managers to analytically estimate and graphically display facility vulnerability and changes (reductions) in vulnerability which result from the adoption of various bomb defense measures

  17. First fusion neutrons from a thermonuclear weapon device

    International Nuclear Information System (INIS)

    Anon.

    1976-01-01

    An account of the first observation of thermonuclear neutrons from a hydrogen weapon, the George shot, is presented. A personal narrative by the researchers J. Allred and L. Rosen includes such topics as the formation of the experimental team, description of the experimental technique, testing the experimental apparatus, testing the effects of a blast, a description of the test area, and the observation of neutrons from fusion. Excerpts are presented from several chapters of the Scientific Director's report on the atomic weapons tests of 1951. Also included is a brief description of the basic design of the hydrogen bomb, a recounting of subsequent developments, and short scientific biographies of the researchers. 21 figures, 2 tables

  18. Dr. Lytle Adams' incendiary "bat bomb" of World War II.

    Science.gov (United States)

    Christen, Arden G; Christen, Joan A

    2004-11-01

    On December 7, 1941, a 60-year old dentist from Irwin, Pennsylvania, Dr. Lytle S. Adams, was driving home from a vacation at Carlsbad Caverns in New Mexico. Hours earlier, he had been gripped with amazement as he witnessed millions of bats exiting the caves of Carlsbad. Listening to his car radio on his return trip, he was shocked to hear that Japan had just attacked Pearl Harbor. Dr. Adams, outraged over this travesty, began to mentally construct a plan for U.S. retaliation. As his thoughts returned to the countless bats that had awed him, he formed a tentative plan: millions of these small, flying mammals could be connected to tiny, time-fused incendiary bombs, and then released to land on the flimsily constructed structures which dotted the cities of Japan. Within a few minutes, the bombs would explode and enflame the entire urban areas. He postulated that these immeasurable numbers of fires, spreading their devastation over such vast areas within Japanese cities would result in the enemy's speedy surrender. This article documents the futile efforts of Dr. Adams, his team and the U.S. government to develop and employ an effective, incendiary bat bomb. The recently developed atom bomb, a far more deadly weapon was used in its place.

  19. Low dose radiation risks for women surviving the a-bombs in Japan: generalized additive model.

    Science.gov (United States)

    Dropkin, Greg

    2016-11-24

    Analyses of cancer mortality and incidence in Japanese A-bomb survivors have been used to estimate radiation risks, which are generally higher for women. Relative Risk (RR) is usually modelled as a linear function of dose. Extrapolation from data including high doses predicts small risks at low doses. Generalized Additive Models (GAMs) are flexible methods for modelling non-linear behaviour. GAMs are applied to cancer incidence in female low dose subcohorts, using anonymous public data for the 1958 - 1998 Life Span Study, to test for linearity, explore interactions, adjust for the skewed dose distribution, examine significance below 100 mGy, and estimate risks at 10 mGy. For all solid cancer incidence, RR estimated from 0 - 100 mGy and 0 - 20 mGy subcohorts is significantly raised. The response tapers above 150 mGy. At low doses, RR increases with age-at-exposure and decreases with time-since-exposure, the preferred covariate. Using the empirical cumulative distribution of dose improves model fit, and capacity to detect non-linear responses. RR is elevated over wide ranges of covariate values. Results are stable under simulation, or when removing exceptional data cells, or adjusting neutron RBE. Estimates of Excess RR at 10 mGy using the cumulative dose distribution are 10 - 45 times higher than extrapolations from a linear model fitted to the full cohort. Below 100 mGy, quasipoisson models find significant effects for all solid, squamous, uterus, corpus, and thyroid cancers, and for respiratory cancers when age-at-exposure > 35 yrs. Results for the thyroid are compatible with studies of children treated for tinea capitis, and Chernobyl survivors. Results for the uterus are compatible with studies of UK nuclear workers and the Techa River cohort. Non-linear models find large, significant cancer risks for Japanese women exposed to low dose radiation from the atomic bombings. The risks should be reflected in protection standards.

  20. Method Comparison of Neutron Activation Analysis and Atomic Absorption Spectrometry for Determination of Zinc in Food Samples

    International Nuclear Information System (INIS)

    Endah Damastuti; Syukria Kurniawati; Natalia Adventini

    2009-01-01

    Zinc as a micro nutrient, has important roles in human metabolism system. It is required by the body in appropriate amount from food intake. Due to the very low concentration of Zinc in food, high selectivity and sensitivity analysis technique is required for the determination, such as Neutron Activation Analysis (NAA) and Atomic Absorption Spectrometry (AAS). In this experiment, both methods were compared in zinc analysis of food samples. The subject of this experiment is to examine of those methods conformity and improving the technique capability in zinc analysis in food sample. Those methods were validated by analyzing zinc in SRM NIST 1548a Typical Diet and were tested its accuracy and precision. The results of Zn concentration were 25.1 ± 2.14 mg/kg by NAA and 24.1 ± 1.40 mg/kg by AAS while the certificate value was 24.6 ± 1.80 mg/kg. Percentage of relative bias, %CV, μ-test score and HORRAT(Horwitz ratio) value given by NAA were 2%, 8.5%, 0.18 and 0.9 respectively, while %relative bias, %CV, μ-test score and HORRAT value given by AAS were 2%, 5.8 %, 0.20 and 0.6 respectively. The result obtained for Zn concentration in various food samples by NAA and AAS were varied from 13.7 – 29.3 mg/kg with mean value 19.8 mg/kg and 11.2 – 26.0 mg/kg with mean value 17.3 mg/kg (author)

  1. Factors affecting neutron measurements and calculations. Part B. Effects of local environment

    International Nuclear Information System (INIS)

    Santoro, Robert T.; Kerr, George D.; Pace, Joseph V. III; Lillie, Richard A.

    2005-01-01

    One of the difficulties encountered by Hiroshima and Nagasaki atomic-bomb analysts was achieving agreement between measured and calculated neutron activation data, particularly for the cases of materials that were activated by thermal and epithermal neutrons. In DS86 (Kerr et al. 1987) and the work reported here, the adopted standard was to calculate neutron kerma and neutron activation at 1 m above flat, wet ground as a function of distance from the burst. This two-dimensional air-over-ground model does not account for local effects, because the air-ground interface is a flat surface that offers no local shielding by terrain fluctuations, houses, walls, etc. In addition, the ground composition is assumed to be the same at all ground ranges. The composition of the surface and local environment conditions can have profound impact on the thermal neutron response at 1 m above the ground surface. Depending on the composition of the surface materials and assumptions made for the presence of buildings and other structures, calculated responses might increase or decrease the neutron activation of materials by thermal and epithermal neutrons. The examination of measured neutron activation responses suggests that wide variations did indeed occur. Measured and calculated activation data were, in some cases, found to differ by as much as 10% to 50% depending on location and distance from the hypocenter. In other cases, measured activation data taken at the same ground range often showed differences among themselves. (J.P.N.)

  2. Thermal dynamics of bomb calorimeters

    Science.gov (United States)

    Lyon, Richard E.

    2015-12-01

    The thermal dynamics of bomb calorimeters are modeled using a lumped heat transfer analysis in which heat is released in a pressure vessel/bomb immersed in a stirred water bath that is surrounded by a static air space bounded by an insulated (static) jacket, a constant/controlled temperature jacket (isoperibol), or a changing temperature (adiabatic) jacket. The temperature history of the water bath for each of these boundary conditions (methods) is well described by the two-term solution for the calorimeter response to a heat impulse (combustion), allowing the heat transfer coefficients and thermal capacities of the bomb and water bath to be determined parametrically. The validated heat transfer model provides an expression for direct calculation of the heat released in an arbitrary process inside a bomb calorimeter using the temperature history of the water bath for each of the boundary conditions (methods). This result makes possible the direct calculation of the heat of combustion of a sample in an isoperibol calorimeter from the recorded temperature history without the need for semi-empirical temperature corrections to account for non-adiabatic behavior. Another useful result is that the maximum temperature rise of the water bath in the static jacket method is proportional to the total heat generated, and the empirical proportionality constant, which is determined by calibration, accounts for all of the heat losses and thermal lags of the calorimeter.

  3. Thermal dynamics of bomb calorimeters.

    Science.gov (United States)

    Lyon, Richard E

    2015-12-01

    The thermal dynamics of bomb calorimeters are modeled using a lumped heat transfer analysis in which heat is released in a pressure vessel/bomb immersed in a stirred water bath that is surrounded by a static air space bounded by an insulated (static) jacket, a constant/controlled temperature jacket (isoperibol), or a changing temperature (adiabatic) jacket. The temperature history of the water bath for each of these boundary conditions (methods) is well described by the two-term solution for the calorimeter response to a heat impulse (combustion), allowing the heat transfer coefficients and thermal capacities of the bomb and water bath to be determined parametrically. The validated heat transfer model provides an expression for direct calculation of the heat released in an arbitrary process inside a bomb calorimeter using the temperature history of the water bath for each of the boundary conditions (methods). This result makes possible the direct calculation of the heat of combustion of a sample in an isoperibol calorimeter from the recorded temperature history without the need for semi-empirical temperature corrections to account for non-adiabatic behavior. Another useful result is that the maximum temperature rise of the water bath in the static jacket method is proportional to the total heat generated, and the empirical proportionality constant, which is determined by calibration, accounts for all of the heat losses and thermal lags of the calorimeter.

  4. Cartel Car Bombings in Mexico

    Science.gov (United States)

    2013-08-01

    to have ties to drug traffickers. The Mexico City newspaper Universal reported that police said members of the family of Rafael Caro Quintero...targets of attack and likely the first to respond to a bomb scene. Police and other local level responders (emergency medical services), the Cruz Rojo

  5. Accurate Bond Lengths to Hydrogen Atoms from Single-Crystal X-ray Diffraction by Including Estimated Hydrogen ADPs and Comparison to Neutron and QM/MM Benchmarks.

    Science.gov (United States)

    Dittrich, Birger; Lübben, Jens; Mebs, Stefan; Wagner, Armin; Luger, Peter; Flaig, Ralf

    2017-04-03

    Amino acid structures are an ideal test set for method-development studies in crystallography. High-resolution X-ray diffraction data for eight previously studied genetically encoding amino acids are provided, complemented by a non-standard amino acid. Structures were re-investigated to study a widely applicable treatment that permits accurate X-H bond lengths to hydrogen atoms to be obtained: this treatment combines refinement of positional hydrogen-atom parameters with aspherical scattering factors with constrained "TLS+INV" estimated hydrogen anisotropic displacement parameters (H-ADPs). Tabulated invariom scattering factors allow rapid modeling without further computations, and unconstrained Hirshfeld atom refinement provides a computationally demanding alternative when database entries are missing. Both should incorporate estimated H-ADPs, as free refinement frequently leads to over-parameterization and non-positive definite H-ADPs irrespective of the aspherical scattering model used. Using estimated H-ADPs, both methods yield accurate and precise X-H distances in best quantitative agreement with neutron diffraction data (available for five of the test-set molecules). This work thus solves the last remaining problem to obtain such results more frequently. Density functional theoretical QM/MM computations are able to play the role of an alternative benchmark to neutron diffraction. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  6. Genius in the shadows a biography of Leo Szilard, the man behind the bomb

    CERN Document Server

    Lanouette, William

    2013-01-01

    Well-known names such as Albert Einstein, Enrico Fermi, J. Robert Oppenheimer, and Edward Teller are usually those that surround the creation of the atom bomb. One name that is rarely mentioned is Leo Szilard, known in scientific circles as "father of the atom bomb." The man who first developed the idea of harnessing energy from nuclear chain reactions, he is curiously buried with barely a trace in the history of this well-known and controversial topic.Born in Hungary and educated in Berlin, he escaped Hitler's Germany in 1933 and that first year developed his concept of nucle

  7. Neutron Diffraction Measurements and First Principles Study of Thermal Motion of Atoms in Select M_{n+1}AX_n and Binary MX Transition Metal Carbide Phases

    OpenAIRE

    Lane, Nina J.; Vogel, Sven C.; Hug, Gilles; Togo, Atsushi; Chaput, Laurent; Hultman, Lars; Barsoum, Michel W.

    2012-01-01

    Herein, we compare the thermal vibrations of atoms in select ternary carbides with the formula Mn+1AXn ("MAX phases," M = Ti, Cr; A = Al, Si, Ge; X = C, N) as determined from first principles phonon calculations to those obtained from high-temperature neutron powder diffraction studies. The transition metal carbides TiC, TaC, and WC are also studied to test our methodology on simpler carbides. Good qualitative and quantitative agreement is found between predicted and experimental values for t...

  8. Status of spallation neutron source

    Energy Technology Data Exchange (ETDEWEB)

    Oyama, Yukio [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment

    1997-03-01

    Existing and planned facilities using proton accelerator driven spallation neutron source are reviewed. These include new project of neutron science proposed from Japan Atomic Energy Research Institute. The present status of facility requirement and accelerator technology leads us to new era of neutron science such as neutron scattering research and nuclear transmutation study using very intense neutron source. (author)

  9. The early development of neutron diffraction: science in the wings of the Manhattan Project

    International Nuclear Information System (INIS)

    Mason, T. E.; Gawne, T. J.; Nagler, S. E.; Nestor, M. B.; Carpenter, J. M.

    2013-01-01

    Early neutron diffraction experiments performed in 1944 using the first nuclear reactors are described. Although neutron diffraction was first observed using radioactive decay sources shortly after the discovery of the neutron, it was only with the availability of higher intensity neutron beams from the first nuclear reactors, constructed as part of the Manhattan Project, that systematic investigation of Bragg scattering became possible. Remarkably, at a time when the war effort was singularly focused on the development of the atomic bomb, groups working at Oak Ridge and Chicago carried out key measurements and recognized the future utility of neutron diffraction quite independent of its contributions to the measurement of nuclear cross sections. Ernest O. Wollan, Lyle B. Borst and Walter H. Zinn were all able to observe neutron diffraction in 1944 using the X-10 graphite reactor and the CP-3 heavy water reactor. Subsequent work by Wollan and Clifford G. Shull, who joined Wollan’s group at Oak Ridge in 1946, laid the foundations for widespread application of neutron diffraction as an important research tool

  10. Algorithms for solving atomic structures of nanodimensional clusters in single crystals based on X-ray and neutron diffuse scattering data

    International Nuclear Information System (INIS)

    Andrushevskii, N.M.; Shchedrin, B.M.; Simonov, V.I.

    2004-01-01

    New algorithms for solving the atomic structure of equivalent nanodimensional clusters of the same orientations randomly distributed over the initial single crystal (crystal matrix) have been suggested. A cluster is a compact group of substitutional, interstitial or other atoms displaced from their positions in the crystal matrix. The structure is solved based on X-ray or neutron diffuse scattering data obtained from such objects. The use of the mathematical apparatus of Fourier transformations of finite functions showed that the appropriate sampling of the intensities of continuous diffuse scattering allows one to synthesize multiperiodic difference Patterson functions that reveal the systems of the interatomic vectors of an individual cluster. The suggested algorithms are tested on a model one-dimensional structure

  11. Electronic dipole moment and tunneling state of hydrogen atom in hydrogen-bond materials revealed by neutron and X-ray structure analyses

    International Nuclear Information System (INIS)

    Kiyanagi, Ryoji; Noda, Yukio; Mochida, Tomoyuki; Sugawara, Tadashi

    2007-01-01

    The isolated hydrogen-bonded materials, 5-methyl-9-hydroxyphenalenone (MeHPLN) and 5-bromo-9-hydroxyphenalenone (Br-HPLN), were studied by means of X-ray and neutron diffraction methods. It was found that the position of the nucleus of the hydrogen atom in the hydrogen-bond region does not agree with the center of mass of the electron cloud of the hydrogen atom. This leads to a local electronic dipole moment in the hydrogen-bond region. Using the experimentally obtained dipole moment, phase transition temperatures for MeHPLN and BrHPLN were calculated based on a tunneling model. Result shows good agreement with the ones obtained by a dielectric measurement. (author)

  12. The media and dirty bombs

    International Nuclear Information System (INIS)

    Hanley, C.J.

    2003-01-01

    During the recent Jose Padilla 'dirty bomb' scare, an indignant US citizen wrote to his local newspaper in Florida complaining that the news media were giving terrorists a recipe for making dirty bombs. 'Unless the media eases up on scaring us, he wrote, the public won't feel safe even leaving their homes. Or perhaps that is what they want, he said, 'us staying inside our homes watching the news on how terrorists can destroy us all.' It seems our real motivations have finally been uncovered we in the media want to scare them so much they won't leave their TV screens. Based on the previous event an analysis of the role of media and journalists is discussed. Leaders of the news media would, first of all, universally advise full and rapid and authoritative disclosure of what is known. If it isn't coming quickly from the highest levels, then the news will soon deteriorate to what's being heard on the streets, from police officers and fire fighters and other emergency personnel, and from passers-by. Journalists are the first to acknowledge their ignorance.That is why they ask questions. However, they seem to learn fast. It was found that that the term dirty bomb never appeared on Associated Press news wires before the 11 September 2001 attacks. Now it appears every day, and increasingly we are getting the facts right and helping to prepare our audience of millions for this dangerous new world

  13. Neutron radiography with 252Cf in forensic science

    International Nuclear Information System (INIS)

    Cason, J.L.

    1972-01-01

    Equipment and methods for neutron radiographic examination of objects in forensic science are described. Examples discussed include booby-trapped ammunition, bomb in a matchbook, gun barrel analysis, narcotics in pen, and chemicals and metals in body tissue

  14. Activation Measurements for Thermal Neutrons, Part D. U.S. Measurements of 36Cl in Mineral Samples from Hiroshima and Nagasaki

    International Nuclear Information System (INIS)

    Tore Straume; Alfredo A, Marchetti; Stephen D, Egbert; James A, Roberts; Ping Men; Shoichiro Fujita; Kiyoshi Shizuma; Masaharu Hoshi; G, Rugel; W, Ruhm; G, Korschinek; J. E. McAninch; K. L. Carroll; T. Faestermann; K. Knie; R. E. Martinelli; A. Wallner; C. Wallner

    2005-01-01

    The present paper presents the 36 Cl measurement effort in the US. A large number of 36 Cl measurements have been made in both granite and concrete samples obtained from various locations and distances in Hiroshima and Nagasaki. These measurements employed accelerator mass spectrometry (AMS) to quantify the number of atoms of 36 Cl per atom of total Cl in the sample. Results from these measurements are presented here and discussed in the context of the DS02 dosimetry reevaluation effort for Hiroshima and Nagasaki atomic-bomb survivors. The production of 36 Cl by bomb neutrons in mineral samples from Hiroshima and Nagasaki was primarily via the reaction 35 Cl(n,γ) 36 Cl. This reaction has a substantial thermal neutron cross-section (43.6 b at 0.025 eV) and the product has a long half-life (301,000 y). hence, it is well suited for neutron-activation detection in Hiroshima and Nagasaki using AMS more than 50 years after the bombings. A less important reaction for bomb neutrons, 39 K(n,α) 36 Cl, typically produces less than 10% of the 36 Cl in mineral samples such as granite and concrete, which contain ∼ 2% potassium. In 1988, only a year after the publication of the DS86 final report (Roesch 1987), it was demonstrated experimentally that 36 Cl measured using AMS should be able to detect the thermal neutron fluences at the large distances most relevant to the A-bomb survivor dosimetry. Subsequent measurements in mineral samples from both Hiroshima and Nagasaki validated the experimental findings. The potential utility of 36 Cl as a thermal neutron detector in Hiroshima was first presented by Haberstock et al. who employed the Munich AMS facility to measure 36 Cl/Cl ratios in a gravestone from near the hypocenter. That work subsequently resulted in an expanded 36 Cl effort in Germany that paralleled the US work. More recently, there have also been 36 Cl measurements made by a Japanese group. The impetus for the extensive 36 Cl and other neutron activation

  15. Atomic-resolution study of homogeneous radiation-induced precipitation in a neutron-irradiated W-10 at. % Re alloy. MSC report No. 5014

    International Nuclear Information System (INIS)

    Herschitz, R.; Seidman, D.N.

    1983-06-01

    The phenomenon of radiation-induced precipitation has been investigated in a W-10 at. % Re alloy using the atom-probe field-ion microscope. Results show a significant alteration of the microstructure of this alloy as a result of the fast-neutron irradiation. Precipitates with the composition approx. WRe (sigma phase) were detected at a density of 10 16 cm -3 . Coherent, semicoherent and possibly incoherent precipitates of the sigma phase have been observed. They were not associated with either linear or planar defects, or with any impurity atoms; i.e. a true homogeneous radiation-induced precipitation occurs in this alloy. A physical argument is presented for the nucleation of the sigma phase precipitates in the vicinity of displacement cascades produced by primary knock-on atoms. It is suggested that the nucleation of the sigma phase is due to the formation of tightly-bound mobil mixed dumbells which react to form an immobile rhenium cluster. The growth of this cluster into a precipitate is most likely driven by the irreversible vacancy: self-interstitial atom (SIA) annihilation reaction, as suggested recently by Cauvin and Martin. A mechanism for the suppression of voids, in this alloy, is presented which is self-consistent with the homogeneous radiation-induced precipitation mechanism

  16. Elemental characterization of herbal medicines used in Ghana by instrumental neutron activation analysis and atomic absorption spectrometry and multivariate statistical analysis

    International Nuclear Information System (INIS)

    Ayivor, J.E.; Nyarko, B.J.B.; Dampare, S.B.; Okine, L.K.

    2010-01-01

    k 0 instrumental neutron activation analysis and atomic absorption spectrometry were applied to determine multi elements in thirteen Ghanaian herbal medicines used for the management of various diseases. Concentrations of AI, Cu, Mg, Mn and Na were determined. As, Br, K, CI, and Na were determined by short and medium irradiations at a thermal neutron flux of 5x10ncm -2 s -1 . Fe, Cr, Pb, Co, Ni, Sn, Ca, Ba, Li and Sb were determined using atomic absorption spectrometry. Ba, Cu, Li and V were present at trace levels whereas AI, CI, Na, Ca were present at major levels. K, Br, Mg, Mn, Co, Ni, Fe and Sb were also present at minor levels. The precision and accuracy of the method using real samples and standard reference materials were within ±10% of the reported value. Multivariate analytical techniques, such as cluster analysis and principal component analysis (PCA)/factor analysis (FA), have been applied to evaluate the chemical variations in the herbal medicine dataset. All the 13 samples may be grouped into two statistically significant clusters, reflecting the different chemical compositions. The concentrations of elements were within the recommended daily allowances or maximum permissible levels posing no adverse effects on human health.

  17. Neutron structure analysis using neutron imaging plate

    International Nuclear Information System (INIS)

    Karasawa, Yuko; Minezaki, Yoshiaki; Niimura, Nobuo

    1997-01-01

    Neutron is complementary against X-ray and is dispensable for structure analysis. However, because of the lack of the neutron intensity, it was not so common as X-ray. In order to overcome the intensity problem, a neutron imaging plate (NIP) has been successfully developed. The NIP has opened the door of neutron structure biology, where all the hydrogen atoms and bound water molecules of protein are determined, and contributed to development of other fields such as neutron powder diffraction and neutron radiography, too. (author)

  18. Patenting the bomb: nuclear weapons, intellectual property, and technological control.

    Science.gov (United States)

    Wellerstein, Alex

    2008-03-01

    During the course of the Manhattan Project, the U.S. government secretly attempted to acquire a monopoly on the patent rights for inventions used in the production of nuclear weapons and nuclear energy. The use of patents as a system of control, while common for more mundane technologies, would seem at first glance to conflict with the regimes of secrecy that have traditionally been associated with nuclear weapons. In explaining the origins and operations of the Manhattan Project patent system, though, this essay argues that the utilization of patents was an ad hoc attempt at legal control of the atomic bomb by Manhattan Project administrators, focused on the monopolistic aspects of the patent system and preexisting patent secrecy legislation. From the present perspective, using patents as a method of control for such weapons seems inadequate, if not unnecessary; but at the time, when the bomb was a new and essentially unregulated technology, patents played an important role in the thinking of project administrators concerned with meaningful postwar control of the bomb.

  19. K projektu sovětských atomových bomb

    Czech Academy of Sciences Publication Activity Database

    Jindra, Jiří

    2017-01-01

    Roč. 111, č. 7 (2017), s. 472 ISSN 0009-2770 Institutional support: RVO:68378114 Keywords : Soviet Union * atomic bombs Subject RIV: AB - History OBOR OECD: History (history of science and technology to be 6.3, history of specific sciences to be under the respective headings) Impact factor: 0.387, year: 2016

  20. The bomb and the men

    International Nuclear Information System (INIS)

    Kroh, Aleksandra

    2011-01-01

    Since 1945, more than 2000 nuclear weapon tests have been performed in the world, with a perfect knowledge of the irradiation risks. This book tells this story. The one of the men who designed the bombs, who used and improved them. It tells also the story of these men who were injured by nuclear weapons and those who were directly impacted by the fallouts of these tests. Finally, the book does not forget to mention the men who voluntarily dissimulated the ravages of nuclear weapons before discretely recognizing them and thinking of repairing the damage

  1. Combined use of small-angle neutron scattering and atom probe tomography for the analysis of precipitates in a Fe-15 m% Co-25 m% Mo alloy

    International Nuclear Information System (INIS)

    Eidenberger, Elisabeth; Stergar, Erich; Clemens, Helmut; Leitner, Harald; Staron, Peter; Spitaler, Juergen; Ambrosch-Draxl, Claudia

    2009-01-01

    Atom probe tomography (APT) measurements were conducted to analyze nm-sized precipitates in a Fe-25 m% Co-15 m% Mo model alloy. Calculation of isoconcentration surfaces and application of cluster-search algorithms yielded the chemical compositions of matrix and precipitates. Small-angle neutron scattering (SANS) was performed in order to calculate the ratio of magnetic to nuclear scattering. This so-called A-ratio was compared with values calculated from the chemical information derived from the atom probe data. For this, the magnetism of the precipitates has to be taken into account. Ab-initio studies have been carried out to determine the magnetic moment of the precipitate phase. The results show that the extremely fine precipitates are ferromagnetic and exhibit near-equilibrium composition. In the very early stage of decomposition, however, the composition is different from near-equilibrium. The influences of the magnetism of the precipitates as well as of artifacts from atom probe measurements on the obtained results are discussed. (orig.)

  2. Factors affecting neutron measurements and calculations. Part F. Water content in granite

    International Nuclear Information System (INIS)

    Iwatani, Kazuo; Hasai, Hiromi; Shizuma, Kiyoshi; Hoshi, Masaharu; Endo, Satoru; Oka, Takamitsu; Imanaka, Tetsuji

    2005-01-01

    As part of the DS02 studies to reevaluate neutrons from the atomic bomb, we cored rock samples from a pillar of Motoyasu Bridge, located at a distance of 128 m from the hypocenter in Hiroshima, and measured the depth profile of induced 152 Eu radioactivity in the rock (Hasai et al. 1987). By use of the MCNP neutron transport calculation code, the depth profile of 152 Eu in the rock was calculated, assuming a neutron distribution at the given location around the pillar based on the DS86 calculations. The depth profile was then compared with the distribution of measurements (Endo et al. 1999). For the calculation, it is necessary to know the major components of the rock. It is also necessary to estimate the water content correctly, since the cross section of hydrogen-neutron reactions is large, and neutron moderation effects of hydrogen are significant. For this purpose, the basic characteristics of water content in rock were studied, based on a few characteristic experiments to estimate the water content, which was then used in neutron transport calculations. The following describes our concepts and methods. (author)

  3. Pros and cons on ''Hitlers' bomb''. Studies on nuclear research in Germany

    International Nuclear Information System (INIS)

    Karlsch, R.; Petermann, H.

    2007-01-01

    This book reveals a sensation: Under supervision of the SS German scientists tested 1944/45 nuclear bombs on Ruegen and in Thuringia. During this period several hundred prisoners of war and prisoners died. Besides proofs for nuclear weapon testing the author also found a draft for a patent on plutonium bombs and discovered the first functioning German atom reactor in the environs of Berlin. The succeeding book titled above enlarges the spectra of contributions from Saenger PLan to attack New York, researches on minimization of critical mass, the attempt to calculate TNT-equivalence as the presentation of important acteurs occuring during the researches. (GL)

  4. Activation Measurements for Thermal Neutrons, U.S. Measurements of 36Cl in Mineral Samples from Hiroshima and Nagasaki; and Measurement of 63 Ni in Copper Samples From Hiroshima by Accelerator Mass Spectrometry

    Energy Technology Data Exchange (ETDEWEB)

    Tore Straume; Alfredo A. Marchetti; Stephen D. Egbert; James A. Roberts; Ping Men; Shoichiro Fujita; Kiyoshi Shizuma; Masaharu Hoshi; G. Rugel; W. Ruhm; G. Korschinek; J. E. McAninch; K. L. Carroll; T. Faestermann; K. Knie; R. E. Martinelli; A. Wallner; C. Wallner

    2005-01-14

    The present paper presents the {sup 36}Cl measurement effort in the US. A large number of {sup 36}Cl measurements have been made in both granite and concrete samples obtained from various locations and distances in Hiroshima and Nagasaki. These measurements employed accelerator mass spectrometry (AMS) to quantify the number of atoms of {sup 36}Cl per atom of total Cl in the sample. Results from these measurements are presented here and discussed in the context of the DS02 dosimetry reevaluation effort for Hiroshima and Nagasaki atomic-bomb survivors. The production of {sup 36}Cl by bomb neutrons in mineral samples from Hiroshima and Nagasaki was primarily via the reaction {sup 35}Cl(n,{gamma}){sup 36}Cl. This reaction has a substantial thermal neutron cross-section (43.6 b at 0.025 eV) and the product has a long half-life (301,000 y). hence, it is well suited for neutron-activation detection in Hiroshima and Nagasaki using AMS more than 50 years after the bombings. A less important reaction for bomb neutrons, {sup 39}K(n,{alpha}){sup 36}Cl, typically produces less than 10% of the {sup 36}Cl in mineral samples such as granite and concrete, which contain {approx} 2% potassium. In 1988, only a year after the publication of the DS86 final report (Roesch 1987), it was demonstrated experimentally that {sup 36}Cl measured using AMS should be able to detect the thermal neutron fluences at the large distances most relevant to the A-bomb survivor dosimetry. Subsequent measurements in mineral samples from both Hiroshima and Nagasaki validated the experimental findings. The potential utility of {sup 36}Cl as a thermal neutron detector in Hiroshima was first presented by Haberstock et al. who employed the Munich AMS facility to measure {sup 36}Cl/Cl ratios in a gravestone from near the hypocenter. That work subsequently resulted in an expanded {sup 36}Cl effort in Germany that paralleled the US work. More recently, there have also been {sup 36}Cl measurements made by a Japanese

  5. Physics for all, who want to join in conversation. On atomic power, dirty bombs, space research, solar energy, and the global heating; Physik fuer alle, die mitreden wollen. Ueber Atomkraft, schmutzige Bomben, Weltraumforschung, Solarenergie und die globale Erwaermung

    Energy Technology Data Exchange (ETDEWEB)

    Muller, Richard A.

    2009-07-01

    Which dangers contains the global heating really? What can happen at an attack on a atomic power plant?. Which chances offer renewable energies? Questions which are put daily in the pursuing of news - but to which we have only seldomly answers ready, because basic physical knowledge is absent. But it must not even be the great world policy. Already at the decision wether solar cells shall be mounted on the roof or punted on geothermal heat physics are not unimportant. More often than we think it are natural sciences, which yield the foundations for important decisions. Richard A. Muller explains simply and illustratively, how physics determines our life. Thereby he removes prejudices and mediates quite surprising insights.

  6. Neutron diffraction determination of atomic mean-square displacements in cubic compounds of Ni-Al and Ni-Al-Cu systems

    International Nuclear Information System (INIS)

    Khidirov, I.; Mukhtarova, N.N.

    2002-01-01

    The atomic mean-square displacements (AMSD) are some of important characteristics of the solid and can be the main information for determination of a number of other characteristics of substances. In the work AMSD is determined for a number of cubic compounds of Ni-Al, Ni-Al-Cu systems immediately from intensities of neutron diffraction maxima. It is shown by the offered method that in all NiAl x and NiAlCu x compounds with the CsCl - type structure AMSD are near each other and they are practically constant. Therefore it is possible to assume that within the homogeneity region of these compounds the interatomic bond forces are changed insignificantly

  7. Atomic structure of glassy Mg60Cu30Y10 investigated with EXAFS, x-ray and neutron diffraction, and reverse Monte Carlo simulations

    DEFF Research Database (Denmark)

    Jovari, P.; Saksl, K.; Pryds, Nini

    2007-01-01

    Short range order of amorphous Mg60Cu30Y10 was investigated by x-ray and neutron diffraction, Cu and Y K-edge x-ray absorption fine structure measurements, and the reverse Monte Carlo simulation technique. We found that Mg-Mg and Mg-Cu nearest neighbor distances are very similar to values found...... in crystalline Mg2Cu. The Cu-Y coordination number is 1.1 +/- 0.2, and the Cu-Y distance is similar to 4% shorter than the sum of atomic radii, suggesting that attraction between Cu and Y plays an important role in stabilizing the glassy state. Thermal stability and structure evolution upon annealing were also...

  8. Neutron diffraction

    International Nuclear Information System (INIS)

    Elcomb, M.M.

    2002-01-01

    Full text: Thermal neutrons have a particular combination of properties, which make them the probe of choice for a wide range of scattering applications. They penetrate most materials easily, the wavelength matches interatomic spacings, the energy matches the atomic vibrational energies and the magnetic moment allows them to uniquely interact with magnetic structures. Their widely varying scattering length is also used to advantage. It enables the determination of light atoms in the presence of heavy ones: hydrogen in organic molecules, and oxygen in the high Tc superconductors for example, or solving problems in alloy systems where distinction of atoms, which are neighbours in the periodic table, is required. In the 50 years since thermal neutron beams have been used for research there has been a steady increase in applications as technology has advanced. This also applies to the environments in which the materials are studied. In-situ studies at other than ambient temperatures, pressures and magnetic fields are now routine. By using multiple detector channels in powder instruments the data collection rate has increased by an order of magnitude to some extent compensating for the diffuse nature of the neutron source. The applications of neutron scattering are becoming more industrially oriented. The talk will highlight the complementarity of neutrons to other more readily available techniques, and give examples of recent research and applications. Copyright (2002) Australian X-ray Analytical Association Inc

  9. Atomic hydrogen reactor

    International Nuclear Information System (INIS)

    Massip de Turville, C.M.D.

    1982-01-01

    Methods are discussed of generating heat in an atomic hydrogen reactor which involve; the production of atomic hydrogen by an electrical discharge, the capture of nascent neutrons from atomic hydrogen in a number of surrounding steel alloy tubes having a high manganese content to produce 56 Mn, the irradiation of atomic hydrogen by the high energy antineutrinos from the beta decay of 56 Mn to yield nascent neutrons, and the removal of the heat generated by the capture of nascent neutrons by 55 Mn and the beta decay of 56 Mn. (U.K.)

  10. How Dangerous are 'Dirty Bombs'?

    International Nuclear Information System (INIS)

    Franic, Z.

    2003-01-01

    A radiological weapon (or a radiation weapon) is any weapon that is designed to spread radioactivity, either to kill, or to deny the use of an area (a modern version of salting the earth) and consists of a device (such as a nuclear or conventional explosive), which spreads radioactive material. Recently, it has been called 'dirty bombs'. This term refers especially to a weapon that would disperse radioactive material through conventional explosives. The term was put in focus in June 2002, when U. S. officials announced they had captured an al-Qaida terrorist in Chicago who was allegedly planning for such a device. Designed to produce radiation sickness in a military force or a civilian population instead of destroying a target, Iraq developed and tested radiation weapons in 1980s, during the war with Iran with intention to produce health effects that would be difficult to explain. The project was abandoned because a radiation levels low enough to escape detection were also insufficient to cause significant medical problems in the weeks following an attack. Radiological weapons are therefore widely considered to be militarily useless for a state-sponsored army and are not believed to have been deployed by any military forces. However, these weapons have been suggested as a possible terror weapon in order to create fear and panic in densely populated areas and havoc to local economies. They do not require weapons-grade materials, and common materials such as 1 37C s used in radiological medical equipment, could be used. Subsequent removal of urban radioactive contamination, i.e. cleanup efforts according to experiences from the radiological accident in a Brazilian city of Goiania could be long, difficult and costly. Therefore, the overall effects of exploded dirty bombs are hard to assess considering that: a) The health effects of low-level radiation are hotly contested. Namely, according to 'linear, no-threshold' dosimetric model, any increase over background is

  11. Estimated H-atom anisotropic displacement parameters: a comparison between different methods and with neutron diffraction results

    DEFF Research Database (Denmark)

    Munshi, Parthapratim; Madsen, Anders Ø; Spackman, Mark A

    2008-01-01

    results is substantial, suggesting that this is now the most readily and widely applicable of the three approximate procedures. Using this new library--SHADE2--it is shown that, in line with expectations, a segmented rigid-body description of the heavy atoms yields only a small improvement...

  12. High mammary carcinogenicity of neutron irradiation in rats and its promotion by prolactin

    International Nuclear Information System (INIS)

    Kamiya, Kenji; Inoh, Akira; Fujii, Yoshiaki; Kanda, Keiji; Kobayashi, Tooru; Yokoro, Kenjiro.

    1985-01-01

    The present study was undertaken to assess the mammary carcinogenic effect of low doses of fission and thermal neutrons in female W/Fu rats. Only 2 of 62 (3.2%) rats exposed to various doses of fission radiation alone developed mammary tumors (MT) in a 12-month observation period, whereas 21 of 63 (33.3%) similarly irradiated rats developed MT if further treated with prolactin; the lowest effective dose was 4.1 rad, which contained only 1.7 rad of fission spectrum neutrons with an average energy of 2.0 MeV. The long survival of radiation-initiated potentially malignant cells was suggested by the observation that excess numbers of MT developed in irradiated rats in whom prolactin treatment was started as late as 12 months after irradiation. The negligible contribution of gamma-rays, one component of the reactor radiations, to the rat mammary carcinogenesis was proven by a simulation experiment with 60 Co gamma-rays. Thermal neutrons with an average energy of 0.025 eV were less effective than fission neutrons. The rat mammary carcinogenic effects of 180 kVp X-rays, 14.1 MeV fast neutrons, 0.025 eV thermal neutrons and 2.0 MeV fission neutrons were estimated in such a way as to compare the dose of each radiation that gave an MT incidence of 40% of that in irradiated, prolactin-treated rats. The efficiency of fission spectrum neutrons is much higher than those of other radiations; the relative biological effectiveness (RBE) of fission spectrum neutrons was 17.8 against X-rays. Based on these findings, the relevance of animal data to tumor induction in atomic bomb survivors is discussed. (author)

  13. A high precision gas flow cell for performing in situ neutron studies of local atomic structure in catalytic materials.

    Science.gov (United States)

    Olds, Daniel; Page, Katharine; Paecklar, Arnold; Peterson, Peter F; Liu, Jue; Rucker, Gerald; Ruiz-Rodriguez, Mariano; Olsen, Michael; Pawel, Michelle; Overbury, Steven H; Neilson, James R

    2017-03-01

    Gas-solid interfaces enable a multitude of industrial processes, including heterogeneous catalysis; however, there are few methods available for studying the structure of this interface under operating conditions. Here, we present a new sample environment for interrogating materials under gas-flow conditions using time-of-flight neutron scattering under both constant and pulse probe gas flow. Outlined are descriptions of the gas flow cell and a commissioning example using the adsorption of N 2 by Ca-exchanged zeolite-X (Na 78-2x Ca x Al 78 Si 144 O 384 ,x ≈ 38). We demonstrate sensitivities to lattice contraction and N 2 adsorption sites in the structure, with both static gas loading and gas flow. A steady-state isotope transient kinetic analysis of N 2 adsorption measured simultaneously with mass spectrometry is also demonstrated. In the experiment, the gas flow through a plugged-flow gas-solid contactor is switched between N215 and N214 isotopes at a temperature of 300 K and a constant pressure of 1 atm; the gas flow and mass spectrum are correlated with the structure factor determined from event-based neutron total scattering. Available flow conditions, sample considerations, and future applications are discussed.

  14. A high precision gas flow cell for performing in situ neutron studies of local atomic structure in catalytic materials

    Science.gov (United States)

    Olds, Daniel; Page, Katharine; Paecklar, Arnold; Peterson, Peter F.; Liu, Jue; Rucker, Gerald; Ruiz-Rodriguez, Mariano; Olsen, Michael; Pawel, Michelle; Overbury, Steven H.; Neilson, James R.

    2017-03-01

    Gas-solid interfaces enable a multitude of industrial processes, including heterogeneous catalysis; however, there are few methods available for studying the structure of this interface under operating conditions. Here, we present a new sample environment for interrogating materials under gas-flow conditions using time-of-flight neutron scattering under both constant and pulse probe gas flow. Outlined are descriptions of the gas flow cell and a commissioning example using the adsorption of N2 by Ca-exchanged zeolite-X (Na78-2xCaxAl78Si144O384,x ≈ 38). We demonstrate sensitivities to lattice contraction and N2 adsorption sites in the structure, with both static gas loading and gas flow. A steady-state isotope transient kinetic analysis of N2 adsorption measured simultaneously with mass spectrometry is also demonstrated. In the experiment, the gas flow through a plugged-flow gas-solid contactor is switched between 15N2 and 14N2 isotopes at a temperature of 300 K and a constant pressure of 1 atm; the gas flow and mass spectrum are correlated with the structure factor determined from event-based neutron total scattering. Available flow conditions, sample considerations, and future applications are discussed.

  15. Neuropsychiatric and psychologic effects of A-bomb radiation

    International Nuclear Information System (INIS)

    Yamada, Michiko; Sasaki, Hideo

    1992-01-01

    Few studies have assessed the influences of A-bombing from both psychiatric and psychologic points of view. This chapter deals with the knowledge of neuropsychiatric and psychologic influences of A-bombing. Many A-bomb survivors were exposed not only to radiation but also to rapid environmental alterations, such as death of family members and destruction of living. In addition, they suffered from sequelae and anxiety. Naturally, these were considered to cause psychological disturbance including autonomic imbalance and neurosis. Psychological survey, made immediately after A-bombing, is presented, with special attention to behavioral patterns in 54 A-bomb survivors by dividing them into 5 stimulation groups. Radiation syndrome occurring early after exposure and leukemia or cancer occurring later were referred to as 'Genbaku-sho' (A-bomb disease). A-bomb survivors' physically eventful conditions tended to induce mental anxiety or the contrary. Depression and phobia seemed to have correlated with physical conditions. In addition to 'A-bomb disease', mass media, dealing with 'A-bomb neurosis,' 'marriage in A-bomb survivors,' 'suicide in A-bomb survivors,' 'A-bomb survivors orphan,' and 'lonely old A-bomb survivors,' had a great impact on A-bomb survivors. For in uterus exposed and infantile A-bomb survivors, there was no significant difference between the exposed and non-exposed groups, although the incidence of eye tremor and sleeping disorder is found to be higher in the in uterus exposed group than the control group. (N.K.)

  16. 750 Pound M117 Bomb Transportability Tests

    National Research Council Canada - National Science Library

    Meyer, William

    1999-01-01

    The US Army Defense Ammunition Center (DAC) Validation Engineering Division (SIOAC-DEV) was tasked by the US Army Pacific, Fort Shafter, HI to conduct transportability tests on modified 750 pound bombs...

  17. BOMB BLAST: PATTERN AND NATURE OF INJURIES

    OpenAIRE

    Brahmaji Master; Chandra Sekhar; Rangaiah

    2015-01-01

    Bomb blast cause injury on large groups of people by multiple mechanisms. Bomb blast injuries differ from the conventional description of trauma complexity. Primary injuries are caused by blast wave and over pressure. Secondary injuries are caused by flyin g debris and cause shrapnel wounds. Tertiary injuries are caused by blast wind due to forceful impact and quaternary injuries are caused by other vectors like heat, radiation etc. Combined injuries, especially blast and...

  18. fissioncore: A desktop-computer simulation of a fission-bomb core

    Science.gov (United States)

    Cameron Reed, B.; Rohe, Klaus

    2014-10-01

    A computer program, fissioncore, has been developed to deterministically simulate the growth of the number of neutrons within an exploding fission-bomb core. The program allows users to explore the dependence of criticality conditions on parameters such as nuclear cross-sections, core radius, number of secondary neutrons liberated per fission, and the distance between nuclei. Simulations clearly illustrate the existence of a critical radius given a particular set of parameter values, as well as how the exponential growth of the neutron population (the condition that characterizes criticality) depends on these parameters. No understanding of neutron diffusion theory is necessary to appreciate the logic of the program or the results. The code is freely available in FORTRAN, C, and Java and is configured so that modifications to accommodate more refined physical conditions are possible.

  19. Neutron structural biology

    Energy Technology Data Exchange (ETDEWEB)

    Niimura, Nobuo [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment

    1998-03-01

    Neutron diffraction provides an experimental method of directly locating hydrogen atoms in protein which play important roles in physiological functions. However, there are relatively few examples of neutron crystallography in biology since it takes a lot of time to collect a sufficient number of Bragg reflections due to the low flux of neutrons illuminating the sample. In order to overcome the flux problem, we have successfully developed the neutron IP, where the neutron converter, {sup 6}Li or Gd, was mixed with a photostimulated luminescence material on flexible plastic support. Neutron Laue diffraction 2A data from tetragonal lysozyme were collected for 10 days with neutron imaging plates, and 960 hydrogen atoms in the molecule and 157 bound water molecules were identified. These results explain the proposed hydrolysis mechanism of the sugar by the lysozyme molecule and that lysozyme is less active at pH7.0. (author)

  20. Australia's atomic conspiracy theory

    International Nuclear Information System (INIS)

    Binnie, A.

    2001-01-01

    The author questions claims by the Newcastle University historian Wayne Reynolds in his book 'Australia's Bid for the Bomb', that the impetus behind the Snowy Mountains Scheme was to provide a secure source of power for the enrichment of uranium and production of heavy water so that Australia could produce its own atomic bombs. Reynolds also argued that the Australian Atomic Energy Commission (AAEC) was set up so that Australia had a trained scientific workforce to produce plutonium for the bomb. While the book is well researched, Reynolds does not seem to understand the principles of basic science and engineering. After the Second World War, a manufacturing and industrial base with a skilled and trained workforce was needed so it could be converted to war or defence manufacturing when the need arose. This new manufacturing community would require electrical power to sustain it. Hydroelectricity and atomic energy could help provide these needs. Even though war was still raging, Prime Minister John Curtin looked ahead and set up a Department of Post-War Reconstruction. It was through this department that the Snowy Mountains Scheme would be established. Curtin did not live to see this. He died in 1945 but his successor, Ben Chifley, continued the vision. The author believes, an understanding of the science behind these developments and an appreciation of how how humans interact with each others when it comes to getting something they want is likely to give a more balanced view of the past

  1. Neutron structural biology

    International Nuclear Information System (INIS)

    Niimura, Nobuo

    1999-01-01

    Neutron structural biology will be one of the most important fields in the life sciences which will interest human beings in the 21st century because neutrons can provide not only the position of hydrogen atoms in biological macromolecules but also the dynamic molecular motion of hydrogen atoms and water molecules. However, there are only a few examples experimentally determined at present because of the lack of neutron source intensity. Next generation neutron source scheduled in JAERI (Performance of which is 100 times better than that of JRR-3M) opens the life science of the 21st century. (author)

  2. Correlating structure and photocurrent for composite semiconducting nanoparticles with contrast variation small-angle neutron scattering and photoconductive atomic force microscopy.

    Science.gov (United States)

    Richards, Jeffrey J; Whittle, Curtis L; Shao, Guozheng; Pozzo, Lilo D

    2014-05-27

    Aqueous dispersions of semiconducting nanoparticles have shown promise as a robust and scalable platform for the production of efficient polymer/fullerene active layers in organic photovoltaic applications. Semiconducting nanoparticles are a composite of both an n-type and p-type semiconductor contained within a single nanoparticle. In order to realize efficient organic solar cells from these materials, there is a need to understand how the size and internal distribution of materials within each nanoparticle contributes to photocurrent generation in a nanoparticle-derived device. Therefore, characterizing the internal distribution of conjugated polymer and fullerene within the dispersion is the first step to improving performance. To date, study of polymer/fullerene structure within these nanoparticles has been limited to microscopy techniques of deposited nanoparticles. In this work, we use contrast variation with small-angle neutron scattering to determine the internal distribution of poly(3-hexylthiophene) and [6,6]phenyl-C61-butyric acid methyl ester inside the composite nanoparticles as a function of formulation while in dispersion. On the basis of these measurements, we connect the formulation of these nanoparticles with their internal structure. Using electrostatic deposited monolayers of these nanoparticles, we characterize intrinsic charge generation using photoconductive atomic force microscopy and correlate this with structures determined from small-angle neutron scattering measurements. These techniques combined show that the best performing composite nanoparticles are those that have a uniform distribution of conjugated polymer and fullerene throughout the nanoparticle volume such that electrons and holes are easily transported out of the particle.

  3. Red China’s Capitalist Bomb: Inside the Chinese Neutron Bomb Program

    Science.gov (United States)

    2015-01-01

    this variable could include a “policy entrepreneur ” who invested time, energy, and reputation into opening a policy window for the ERW program.28 U.S...military examples of such entrepreneurism include Charles Draper’s ad- vocacy for increasingly accurate missile guidance systems and Admiral Hyman...certainly must also do.”87 This mindset likely drove Deng’s prioritization of China’s new generation of nuclear weapons in the 1970s and 1980s, which

  4. Neutron range spectrometer

    Science.gov (United States)

    Manglos, Stephen H.

    1989-06-06

    A neutron range spectrometer and method for determining the neutron energy spectrum of a neutron emitting source are disclosed. Neutrons from the source are collimnated along a collimation axis and a position sensitive neutron counter is disposed in the path of the collimated neutron beam. The counter determines positions along the collimation axis of interactions between the neutrons in the neutron beam and a neutron-absorbing material in the counter. From the interaction positions, a computer analyzes the data and determines the neutron energy spectrum of the neutron beam. The counter is preferably shielded and a suitable neutron-absorbing material is He-3. The computer solves the following equation in the analysis: ##EQU1## where: N(x).DELTA.x=the number of neutron interactions measured between a position x and x+.DELTA.x, A.sub.i (E.sub.i).DELTA.E.sub.i =the number of incident neutrons with energy between E.sub.i and E.sub.i +.DELTA.E.sub.i, and C=C(E.sub.i)=N .sigma.(E.sub.i) where N=the number density of absorbing atoms in the position sensitive counter means and .sigma. (E.sub.i)=the average cross section of the absorbing interaction between E.sub.i and E.sub.i +.DELTA.E.sub.i.

  5. The contaminated Western Hero and other madness during the Atomic Age; Der verstrahlte Westernheld und anderer Irrsinn aus dem Atomzeitalter

    Energy Technology Data Exchange (ETDEWEB)

    Herzog, Rudolph

    2012-11-01

    The book on mad activities during the Atomic Age includes the following topics: The second most hazardous invention in all time; the red bomb; the story on the tactic nuclear war; the contaminated Western hero or how the bomb came to Alaska; swords into plowshares; the apocalypse machine; flying reactors; how safe is safe?; atomic Australia; nuclear medicine on wrong ways; broken arrows.

  6. Determination of essential and toxic elements in commercial baby foods by instrumental neutron activation analysis and atomic absorption spectrometry; Determinacao dos elementos essenciais e toxicos em alimentos comerciais infantis por analise por ativacao com neutrons e espectrometria de absorcao atomica

    Energy Technology Data Exchange (ETDEWEB)

    Vallinoto, Priscila

    2013-08-01

    The World Health Organization recommends that infants should be breast fed exclusively for at least six months after birth. After this period, it is recommended to start introducing complementary foods, in order to meet the child's nutritional, mineral and energy needs. Commercial food products for infants form an important part of the diet for many babies. Thus, it is very important that such food contains sufficient amounts of minerals. Inadequate complementary feeding is a major cause of high rates of infant malnutrition in developing countries. In this study, essential elements: Ca, Cl, Co, Cr, Fe, K, Mg, Mn, Na, Se and Zn and toxic elements: As, Cd, Hg levels were determined in twenty seven different commercial infant food product samples by Instrumental Neutron Activation Analysis (INAA) and Atomic Absorption Spectrometry (AAS). In order to validate both methodologies the reference material: INCT MPH-2 Mixed Polish Herbs and NIST - SRM 1577b Bovine Liver by INAA and NIST - SRM 1548th Typical Diet and NIST - SRM 1547 Peach Leaves by AAS were analyzed. The twenty seven baby food samples were acquired from Sao Paulo city supermarkets and stores. Essential and toxic elements were determined. Most of the essential element concentrations obtained were lower than the World Health Organization requirements, while concentrations of toxic elements were below the tolerable upper limit. These low essential element concentrations in these samples indicate that infants should not be fed only with commercial complementary foods. (author)

  7. The use of hogdahl convention k0 neutron activation analysis (NAA) standardization method and atomic absortion spectroscopy (ASS) for determination of toxic elements in foodstuffs

    International Nuclear Information System (INIS)

    Ahiamadie, H.

    2008-06-01

    Copper, cadmium, tin, chromium, arsenic, antimony, vanadium and mercury contents were determined in various foodstuffs (Mussa paradisiaca (plantains), Manihot esculentus (cassavas), Vantosoma sagittifolium (cocoyam). Vantosoma sagittifolium leaves (kontomire), Lycopersicum esculentus (tomatoes), Capsicum species (peppers), Solanum melongena (garden eggs), Nbelmoschus esculentus (okro), and Colocasia esculenta (kooko or taro)) produced in the Wassa West District, Ghana. These plants are the basis of human nutrition in the study area. These elements were determined using Hogdahl convention k 0 Instrumental Neutron Activation Analysis (NAA) Standardization Method and Atomic Absorption Spectroscopy (AAS). The elements in the various foodstuffs and their concentration ranges were Cu (16.87-180.06) mg/kg, As (2.68-9.84) µg/g, Cd (0.63-5.64) µg/g, Hg (0.01-67) ng/g, Cr (0.03-3.66) µg/g, Sb (1.1- 18.6) ng/g, Sn (3.4-58.4) ng/g, and V (12-99) ng/g. The study showed that there are high levels of toxic elements in the foodstuffs grown in the mining areas as compared to that of the non-mining area (i.e., control area). This could be attributed to gold mines pollution. Compared to the World Health Organization (WHO) permissible levels of toxic elements in foods, Cu, Cr and Hg were above the permissible levels whereas the concentrations of As, Cd. Sb, Sn and V fall within the permissible levels. (au)

  8. Atomic structure of glassy Mg60Cu30Y10 investigated with EXAFS, x-ray and neutron diffraction, and reverse Monte Carlo simulations

    International Nuclear Information System (INIS)

    Jovari, Pal; Saksl, Karel; Pryds, Nini; Lebech, Bente; Bailey, Nicholas P.; Mellerga ring rd, Anders; Delaplane, Robert G.; Franz, Hermann

    2007-01-01

    Short range order of amorphous Mg 60 Cu 30 Y 10 was investigated by x-ray and neutron diffraction, Cu and Y K-edge x-ray absorption fine structure measurements, and the reverse Monte Carlo simulation technique. We found that Mg-Mg and Mg-Cu nearest neighbor distances are very similar to values found in crystalline Mg 2 Cu. The Cu-Y coordination number is 1.1±0.2, and the Cu-Y distance is ∼4% shorter than the sum of atomic radii, suggesting that attraction between Cu and Y plays an important role in stabilizing the glassy state. Thermal stability and structure evolution upon annealing were also studied by differential scanning calorimetry and in situ x-ray powder diffraction. The alloy shows a glass transition and three crystallization events, the first and dominant one at 456 K corresponding to eutectic crystallization of at least three phases: Mg 2 Cu and most likely cubic MgY and CuMgY

  9. V L Ginzburg and the Atomic Project

    Science.gov (United States)

    Ritus, V. I.

    2017-04-01

    This paper is an expanded version of the author's talk presented at a session of the Physical Sciences Division of the Russian Academy of Sciences celebrating the 100th anniversary of V L Ginzburg's birth. Tamm's Special group was organized in June 1948 with the task to clarify the feasibility of constructing a hydrogen bomb. Having verified and confirmed the calculated results by Ya B Zel'dovich's group, the Tamm group proposed an original hydrogen bomb design, which, following A D Sakharov's idea, consisted of an atomic bomb surrounded spherically by nested uranium and heavy water layers: the heavy water, on V L Ginzburg's suggestion, was replaced by higher-calorie solid lithium-6 deuteride. The ionization implosion of deuterium by uranium, both heated by the atomic bomb's explosion, greatly accelerates nuclear reactions in deuterium and uranium and increases the total energy release. Upon their approval by the KB-11 top researchers, the Atomic project leadership, and the government, the proposals were implemented in the RDS-6s bomb, which was successfully tested on 12 August 1953. Lithium-6 deuteride turned out to be a convenient multipurpose nuclear fuel. The paper highlights the recognition by the leaders of the country and of the Atomic project that fundamental science plays a crucial role in promoting scientists' ideas and proposals.

  10. FENDL/E-2.0. Evaluated nuclear data library of neutron-nucleus interaction cross sections and photon production cross sections and photon-atom interaction cross sections for fusion applications. Version 1, March 1997. Summary documentation

    International Nuclear Information System (INIS)

    Pashchenko, A.B.; Wienke, H.

    1998-01-01

    This document presents the description of a physical tape containing the basic evaluated nuclear data library of neutron-nucleus interaction cross sections, photon production cross sections and photon-atom interaction cross sections for fusion applications. It is part of the evaluated nuclear data library for fusion applications FENDL-2. The data are available cost-free from the Nuclear Data Section upon request. The data can also be retrieved by the user via online access through international computer networks. (author)

  11. AFSC/REFM: Bomb-produced age validation study

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Fish age validation with bomb-produced radiocarbon (14C) requires a known-age Delta14C reference chronology spanning the era of a marine increase in bomb-produced...

  12. Effects of radiation on aging in atomic bomb survivors

    International Nuclear Information System (INIS)

    Okajima, Shunzo; Norimura, Toshiyuki; Ichimaru, Michito; Koike, Masahiko; Yamashita, Kazukuni

    1980-01-01

    Promotion of aging was studied on women over the age of 40 years exposed within 1.4 km from the center of the explosion in Nagasaki in whom exposure doses were proved to be over 100 rad (a exposed group). Women exposed over 2.5 km whose ages were the same as those of the exposed group were selected as controls. The age of the exposed group was estimated from stepwise regression equation based on the measurement of hair, grip strength, systolic blood pressure, an amount of potassium in the whole body, and erythrocyte count, which changed remarkably with time. The estimated age of the exposed group was over one year older than that of controls. Especially, mean estimated age of the exposed group in their forties (the age at the time of exposure, teens) was 1.4 year older than the actual age, which suggests that radiation promote aging. (Tsunoda, M.)

  13. Statistical analysis of the main diseases among atomic bomb survivors

    International Nuclear Information System (INIS)

    Hamada, Tadao; Kuramoto, Kiyoshi; Nambu, Shigeru

    1988-01-01

    Diseases found in 2,104 consequetive inpatients between April 1981 and March 1986 were statistically analyzed. The incidence of disease increased in the following order: diabetes mellitus > heart disease > cerebrovascular disorder > malignancy > hypertensive disease > arteriosclerosis > osteoarthritis. Malignancy is the most common cause of death or the highest mortality rate, followed by heart disease, cerebrovascular disorder, and liver cirrhosis. For the number of autopsy, the order of diseases was: malignancy, cardiovascular disease, gastrointestinal disease, respiratory tract disease, endocrine disease, and hematopoietic disease; for the incidence of autopsy, the order was: liver cirrhosis, diabetes mellitus, cerebrovascular disorder, malignancy, and heart disease. Malignancy accounted for 23 % of the inpatients. The incidence of malignancy increased in the following organs: stomach > liver > colon > lung > breast > biliary tract > esophagus. The incidence of leukemia was low. There was no definitive correlation between the incidence of malignancy and exposure distance, although the incidence of breast cancer tended to be high in the group exposed at ≤2,000 m from the hypocenter. According to age class, gastric cancer was frequent in patients less than 40 years and more than 60 years. Liver cancer was the most common in the sixtieth decade of life of men. The incidence of lung cancer increased with advancing age; the incidence of breast cancer was higher in younger patients. (Namekawa, K.)

  14. Obituary Professor Victor Weisskopf - atom-bomb and CERN physicist

    CERN Multimedia

    Dalyell, T

    2002-01-01

    The rise of Nazism brought horror, humiliation, death and torture to so many free-thinking people - Jews, and other minorities. There were some lucky ones, like the Weisskopf family, who were able to escape. Victor Weisskopf was born and brought up in Austria in the spirit of German culture and said that he considered his transfer from Europe to the USA an invaluable source of intellectual enrichment (2 pages).

  15. The Children of atomic bomb survivors: a genetic study

    National Research Council Canada - National Science Library

    Neel, James V; Schull, William J

    ... Washington, D.C. 1991 i Copyrightline as original; publication to the this true are version of breaks print Page files. the use Please typesetting inserted. original accidentally from been not have book, may paper errors the original typographic the files XML from from some created retained, cannot be recomposed however, has been formattin...

  16. Early Atomic Bomb Casualty Commission perceptions and planning

    International Nuclear Information System (INIS)

    Friedell, H.L.

    1982-01-01

    A description of the kind of research carried on by the Manhattan Project during World War II is presented. At that time scientists were trying to identify acceptable radiation levels, and to ascertain whether any immediate research was needed to support such levels. The author briefly outlines activities to determine any immediate effects of radiation that occurred after the nuclear strikes in Hiroshima and Nagasaki

  17. Development of chronic myelocytic leukemia in atomic bomb survivors

    International Nuclear Information System (INIS)

    Kamada, Nanao; Oguma, Nobuo; Tanaka, Ruji; Kuramoto, Atsushi; Ohkita, Takeshi

    1978-01-01

    On the basis of the evaluation of laboratory findings in 102 cases including 20 cases which were diagnosed as very early stage chronic myelogenic leukemia (CML), chronological orders of the histopathological pictures of CML were shown as follows; myeloid occupation with Ph 1 -positive cells (leucocyte count 10 10 /L)--basophilic leucocytosis thrombocytosis and low activity of neutrocyte-AP (1 - 2 x 10 10 /L)--appearance of immature granulocytes more than 5% in the peripheral blood (2 x 10 10 /L)--increase of serum Vit. B 12 (2.5 x 10 10 /L)--splenomegaly (5 x 10 10 /L)--appearance of subjective symptoms (7 x 10 10 /L or more). The relation between an actual number of Ph 1 -positive cells and time of their appearance (months) can be expressed as log Y = 0.053 + 10.023. It was estimated that it takes about 8 years since one Ph 1 -positive cell appears in the body until the leucocyte count becomes 10 11 /L and the patient consult a doctor. The idea that Ph 1 -positive cells can be transformed to more malignant clones is helpful to understand the pathological feature of acute transformation of CML. (Ueda, J.)

  18. Effect of exposure on health of atomic bomb servivors

    International Nuclear Information System (INIS)

    Fujitomi, Yutaka; Ueno, Yasushi; Nozaki, Tomoko; Kawaguchi, Fujino; Ishida, Setsuyo

    1976-01-01

    The effects of exposure on vital functions of survivors 30 years after exposure were analyzed, including somatic, psychic, and social factors. Of the survivors living in Nagasaki City, a short-distance exposure group (within 1 km, above 925 rad) and a long-distance exposure group (30 km, 0.6 rad) were selected. The questionnaire included acute symptoms at the time of exposure and present subjective symptoms as indicating vital functions, and psychic factors and medical treatment of exposure as social factors. More of the short-distance exposure group complained of decreased vital functions than did those of the long-distance exposure group. Anxiety was mentioned as one of the causes of the present subjective symptoms. It was not thought that there was relationship between the acute symptoms and the present symptoms. A tendency toward decreased hemoglobin was observed in some of the subjects. (Serizawa, K.)

  19. Thyroid diseases among atomic bombs survivors in Nagasaki, 2

    International Nuclear Information System (INIS)

    Yokoyama, Naokata; Toyama, Kyoko; Ochi, Yoshimichi; Morimoto, Isao; Izumi, Motomori; Nagataki, Shigenobu.

    1986-01-01

    This is an interim report of the population-based study on the incidence of thyroid diseases in Nagasaki prefecture. Included in this study were 885 patients receiving detailed examination for suspected thyroid disease, consisting of 575 exposed persons (Group I) and 310 non-exposed persons (Group II). Thyroid diseases occurred in 157 (27 %) of Group I and in 65 (21 %) of Group II. According to the type of thyroid disease, thyroid cancer, thyroid adenoma, non-toxic uninodular and multinodular goiters were more common in Group I than Group II. The incidence of hypothyroidism was higher in Group I than Group II; however, the incidence of Graves' disease or chronic thyroiditis did not differ in the two groups. A trend toward a slightly higher incidence of thyroid cyst was observed in Group I than Group II. (Namekawa, K.)

  20. Dropping The Bomb? On Critical and Cinematic Reactions to Michael Ondaatje's The English Patient

    OpenAIRE

    Pesch, Josef

    2018-01-01

    This paper analyses Anthony Minghella's film adaptation of Michael Ondaatje’s The English Patient. It aims at establishing patterns of transformation and strategies of adaptation. Not only the nostalgie romanticisation, but also the de-politicisation of the novel is critically scrutinized. As dropping all reference to the atomic bomb from the film is the most blatant example of deviation from the novel, critical and political background is provided which may explain this act of self-censorshi...