WorldWideScience

Sample records for atlas discovery potential

  1. Atlas of Astronomical Discoveries

    CERN Document Server

    Schilling, Govert

    2011-01-01

    Four hundred years ago in Middelburg, in the Netherlands, the telescope was invented. The invention unleashed a revolution in the exploration of the universe. Galileo Galilei discovered mountains on the Moon, spots on the Sun, and moons around Jupiter. Christiaan Huygens saw details on Mars and rings around Saturn. William Herschel discovered a new planet and mapped binary stars and nebulae. Other astronomers determined the distances to stars, unraveled the structure of the Milky Way, and discovered the expansion of the universe. And, as telescopes became bigger and more powerful, astronomers delved deeper into the mysteries of the cosmos. In his Atlas of Astronomical Discoveries, astronomy journalist Govert Schilling tells the story of 400 years of telescopic astronomy. He looks at the 100 most important discoveries since the invention of the telescope. In his direct and accessible style, the author takes his readers on an exciting journey encompassing the highlights of four centuries of astronomy. Spectacul...

  2. SUSY discovery potential of the ATLAS detector at an upgraded LHC

    CERN Document Server

    Mullier, Geoffrey; The ATLAS collaboration

    2016-01-01

    The so-called high-luminosity upgrade of the LHC will impose new technological challenges to the ATLAS detector, requiring the partial upgrade of the detector. Scenarios of SUSY sparticle production, among others, have been used as benchmark to drive the design of the component upgrades, and to evaluate the sensitivity of the upgraded accelerator and detector. This talk will give an overview of the expected sensitivity that the ATLAS experiment will have to SUSY sparticle production with 3000 fb$^{-1}$ pf proton-proton collisions collected at a centre of mass energy of 14 TeV.

  3. ATLAS discoveries of optical transients

    Science.gov (United States)

    Tonry, J.; Denneau, L.; Stalder, B.; Heinze, A.; Sherstyuk, A.; Rest, A.; Smith, K. W.; Smartt, S. J.

    2016-09-01

    We report the following transients found by the ATLAS survey (see Tonry et al. ATel #8680). ATLAS is a twin 0.5m telescope system on Haleakala and Mauna Loa. The first unit is operational on Haleakala is robotically surveying the sky. Two filters are used, cyan and orange (denoted c and o, all mags in AB system), more information is on http://www.fallingstar.com.

  4. ATLAS discoveries of optical transients

    Science.gov (United States)

    Tonry, J.; Denneau, L.; Stalder, B.; Heinze, A.; Sherstyuk, A.; Rest, A.; Smith, K. W.; Smartt, S. J.

    2016-06-01

    We report the following transients found by the ATLAS survey (see Tonry et al. ATel #8680). ATLAS is a twin 0.5m telescope system on Haleakala and Mauna Loa. The first unit is operational on Haleakala is robotically surveying the sky. Two filters are used, cyan and orange (denoted c and o, all mags in AB system), more information is on http://www.fallingstar.com.

  5. ATLAS discoveries of optical transients

    Science.gov (United States)

    Tonry, J.; Denneau, L.; Stalder, B.; Heinze, A.; Sherstyuk, A.; Rest, A.; Smith, K. W.; Smartt, S. J.

    2016-08-01

    We report the following transients found by the ATLAS survey (see Tonry et al. ATel #8680). ATLAS is a twin 0.5m telescope system on Haleakala and Mauna Loa. The first unit is operational on Haleakala is robotically surveying the sky. Two filters are used, cyan and orange (denoted c and o, all mags in AB system), more information is on http://www.fallingstar.com.

  6. ATLAS discoveries of optical transients

    Science.gov (United States)

    Tonry, J.; Denneau, L.; Stalder, B.; Heinze, A.; Sherstyuk, A.; Rest, A.; Smith, K. W.; Smartt, S. J.

    2016-10-01

    We report the following transients found by the ATLAS survey (see Tonry et al. ATel #8680). ATLAS is a twin 0.5m telescope system on Haleakala and Mauna Loa. The first unit is operational on Haleakala is robotically surveying the sky. Two filters are used, cyan and orange (denoted c and o, all mags in AB system), more information is on http://www.fallingstar.com.

  7. Study of the Higgs boson discovery potential in the process pp→H/A→μ+μ-/τ+τ- with the ATLAS detector

    International Nuclear Information System (INIS)

    In this thesis, the discovery potential of the ATLAS experiment at the Large Hadron Collider (LHC) at CERN for the heavy neutral Higgs bosons H/A of theMinimal Supersymmetric extension of the Standard Model of particle physics (MSSM) in the decay channels H/A→τ+τ-→e/μ+X and H/A→μ+μ- has been studied. The ATLAS detector is designed to study the full spectrum of the physics phenomena occuring in the proton-proton collisions at 14 TeV center-of-mass energy and to provide answers to the question of the origin of particle masses and of electroweak symmetry breaking. For the studies, the ATLAS muon spectrometer plays an important role. The spectrometer allows for a precise muon momentum measurement independently of other ATLAS subdetectors. The performance of the muon spectrometer depends strongly on the performance of the muon tracking detectors, the Monitored Drift Tube Chambers (MDT). Computer programs have been developed in order to test and verify the ATLAS muon spectrometer simulation, an essential ingredient for data analysis. In addition, dedicated programs for the monitoring of the quality of the data collected by the muon spectrometer have been developed and tested with data from cosmic ray muons. High-quality cosmic ray muon data have been used for the calibration of the MDT-chambers. A new calibration method, called analytical autocalibration, has been tested. The proposed method achieved the required accuracy of 20 μm in the determination of the space-to-drift-time relationship of the drift tubes of the MDT chambers with only 2000 muon tracks per chamber. Reliable muon detector simulation and calibration are essential for the study of the MSSM Higgs boson decays H/A→τ+τ-→e/μ+X and H/A→μ+μ- and of the corresponding background processes. The signal selection and background rejection requirements have been optimized for maximum signal significance. The following results have been obtained for different assumptions on the MSSM Higgs boson

  8. ATLAS Level-1 Jet Trigger Rates and study of the ATLAS discovery potential of the neutral MSSM Higgs bosons in b-jet decay channels

    OpenAIRE

    Mahboubi, Kambiz

    2001-01-01

    The response of the ATLAS calorimeters to electrons, photons and hadrons, in terms of the longitudinal and lateral shower development, is parameterized using the GEANT package and a detailed detector description (DICE). The parameterizations are implemented in the ATLAS Level-1 (LVL1) Calorimeter Trigger fast simulation package which, based on an average detector geometry, simulates the complete chain of the LVL1 calorimeter trigger system. In addition, pile-up effects due to multiple p...

  9. The ATLAS discovery potential for a heavy charged Higgs boson in $gg \\to tbH^{+-}$ with $H^{+-} \\to tb$

    CERN Document Server

    Assamagan, Ketevi A

    2005-01-01

    The feasibility of detecting a heavy charged Higgs boson, m(H^{+-})>m(t)+m(b), decaying in the H^{+-}->tb channel is studied with the fast simulation of the ATLAS detector. We study the gg->H^{+-}tb production process at the LHC which together with the aforementioned decay channel leads to four b-quarks in the final state. The whole production and decay chain reads gg->H^{+-}tb->t\\bar{t}b\\bar{b}->b\\bar{b}b\\bar{b}l\

  10. ATLAS discovery of an optical transient

    Science.gov (United States)

    Tonry, J.; Denneau, L.; Stalder, B.; Heinze, A.; Sherstyuk, A.; Rest, A.; Smith, K. W.; Smartt, S. J.

    2016-08-01

    We report the following transient found by the ATLAS survey (see Tonry et al. ATel #8680). ATLAS is a twin 0.5m telescope system on Haleakala and Mauna Loa. The first unit is operational on Haleakala is robotically surveying the sky. Two filters are used, cyan and orange (denoted c and o, all mags in AB system), more information is on http://www.fallingstar.com.

  11. Smartphones: A Potential Discovery Tool

    OpenAIRE

    Starkweather, Wendy; Stowers, Eva

    2009-01-01

    The anticipated wide adoption of smartphones by researchers is viewed by the authors as a basis for developing mobile-based services. In response to the UNLV Libraries’ strategic plan’s focus on experimentation and outreach, the authors investigate the current and potential role of smartphones as a valuable discovery tool for library users.

  12. Study of the Higgs boson discovery potential in the process pp{yields}H/A{yields}{mu}{sup +}{mu}{sup -}/{tau}{sup +}{tau}{sup -} with the ATLAS detector

    Energy Technology Data Exchange (ETDEWEB)

    Dedes, Georgios

    2008-04-22

    In this thesis, the discovery potential of the ATLAS experiment at the Large Hadron Collider (LHC) at CERN for the heavy neutral Higgs bosons H/A of theMinimal Supersymmetric extension of the Standard Model of particle physics (MSSM) in the decay channels H/A{yields}{tau}{sup +}{tau}{sup -}{yields}e/{mu}+X and H/A{yields}{mu}{sup +}{mu}{sup -} has been studied. The ATLAS detector is designed to study the full spectrum of the physics phenomena occuring in the proton-proton collisions at 14 TeV center-of-mass energy and to provide answers to the question of the origin of particle masses and of electroweak symmetry breaking. For the studies, the ATLAS muon spectrometer plays an important role. The spectrometer allows for a precise muon momentum measurement independently of other ATLAS subdetectors. The performance of the muon spectrometer depends strongly on the performance of the muon tracking detectors, the Monitored Drift Tube Chambers (MDT). Computer programs have been developed in order to test and verify the ATLAS muon spectrometer simulation, an essential ingredient for data analysis. In addition, dedicated programs for the monitoring of the quality of the data collected by the muon spectrometer have been developed and tested with data from cosmic ray muons. High-quality cosmic ray muon data have been used for the calibration of the MDT-chambers. A new calibration method, called analytical autocalibration, has been tested. The proposed method achieved the required accuracy of 20 {mu}m in the determination of the space-to-drift-time relationship of the drift tubes of the MDT chambers with only 2000 muon tracks per chamber. Reliable muon detector simulation and calibration are essential for the study of the MSSM Higgs boson decays H/A{yields}{tau}{sup +}{tau}{sup -}{yields}e/{mu}+X and H/A{yields}{mu}{sup +}{mu}{sup -} and of the corresponding background processes. The signal selection and background rejection requirements have been optimized for maximum signal

  13. Atlas of the potential vegetation of Ethiopia

    DEFF Research Database (Denmark)

    Friis, Ib; Demissew, Sebsebe; van Breugel, Paulo

    recognised, and the descriptions are illustrated with selected photographs from many parts of Ethiopia. Parts of the book is an atlas with 29 map plates and a legend to signatures. This atlas shows the potential distribution of the 15 natural vegetation types. The book also describes the relation between...

  14. Commissioning of the ATLAS electromagnetic calorimeter and Z' {yields} e{sup +}e{sup -} discovery potential in the first LHC data; Mise en service du calorimetre electromagnetique d'Atlas et determination du potentiel de decouverte d'un Z' {yields} e{sup +}e{sup -} dans les premieres donnees LHC

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2009-07-15

    After about fifteen years of development, the ATLAS detector is ready to operate and it recorded, in 2008, several millions of cosmic events as well as first LHC data. This achievement is based on the long experience of beam tests and on the large effort towards the detector in situ commissioning undertaken by the ATLAS collaboration. This promises fast ability to perform searches for evidence of the Higgs boson and new physics. I heavily contributed to the in situ commissioning of the electromagnetic calorimeter. To verify its performance, I studied the first cosmic data taken in 2006 which allowed the first in situ analysis of dead channels, energy reconstruction and detector response uniformity. This participation to the commissioning has continued with the study of the single beam data recorded during the first week of LHC operation (Sept. 2008). Expanding on my expertise of the electromagnetic calorimeter, I focused my physics analysis, prepared with simulation, on the promising discovery potential of new physics at LHC via the di-electron/di-photon decay of new heavy gauge boson in the early LHC data (the first 100 pb{sup -1}). Possible limitations coming from early hardware problems or imperfect electron energy calibration in first data have been estimated. According to the new schedule of LHC operation, this analysis will be possible with 10 TeV pp collisions data in 2010. (author)

  15. ATLAS discoveries of optical transients : 4 supernova candidates

    Science.gov (United States)

    Tonry, J.; Denneau, L.; Stalder, B.; Heinze, A.; Sherstyuk, A.; Rest, A.; Smith, K. W.; Smartt, S. J.

    2016-06-01

    We report the following transients found by the ATLAS survey (see Tonry et al. ATel #8680). ATLAS is a twin 0.5m telescope system on Haleakala and Mauna Loa. The first unit is operational on Haleakala and is robotically surveying the sky. Two filters are used, cyan and orange (denoted c and o, all mags in AB system), more information is on http://www.fallingstar.com.

  16. ATLAS discoveries of optical transients : 6 supernova candidates

    Science.gov (United States)

    Tonry, J.; Denneau, L.; Stalder, B.; Heinze, A.; Sherstyuk, A.; Rest, A.; Smith, K. W.; Smartt, S. J.

    2016-06-01

    We report the following transients found by the ATLAS survey (see Tonry et al. ATel #8680). ATLAS is a twin 0.5m telescope system on Haleakala and Mauna Loa. The first unit is operational on Haleakala and is robotically surveying the sky. Two filters are used, cyan and orange (denoted c and o, all mags in AB system), more information is on http://www.fallingstar.com.

  17. EnviroAtlas - Potential Wetland Areas - Contiguous United States

    Data.gov (United States)

    U.S. Environmental Protection Agency — The EnviroAtlas Potential Wetland Areas (PWA) dataset shows potential wetland areas at 30-meter resolution. Beginning two centuries ago, many wetlands were turned...

  18. EnviroAtlas - Potentially Restorable Wetlands on Agricultural Land - Contiguous United States Web Service

    Data.gov (United States)

    U.S. Environmental Protection Agency — This EnviroAtlas web service supports research and online mapping activities related to EnviroAtlas (https://www.epa.gov/enviroatlas). The EnviroAtlas Potentially...

  19. EnviroAtlas - Potential Wetland Areas - Contiguous United States Web Service

    Data.gov (United States)

    U.S. Environmental Protection Agency — This EnviroAtlas web service supports research and online mapping activities related to EnviroAtlas (https://www.epa.gov/enviroatlas). The EnviroAtlas Potential...

  20. The discovery potential of laser polarization experiments

    Energy Technology Data Exchange (ETDEWEB)

    Ahlers, Markus [Oxford Univ. (United Kingdom). Rudolf Peierls Centre for Theoretical Physics; Jaeckel, Joerg [Durham Univ. (United Kingdom). Inst. for Particle Physics and Phenomenology; Ringwald, Andreas [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany)

    2008-12-15

    Currently, a number of experiments are searching for vacuum magnetic birefringence and dichroism, i.e. for dispersive and absorptive features in the propagation of polarized light along a transverse magnetic field in vacuum. In this note we calculate the Standard Model contributions to these signatures, thereby illuminating the discovery potential of such experiments in the search for new physics. We discuss the three main sources for a Standard Model contribution to a dichroism signal: photon splitting, neutrino pair production and production of gravitons. (orig.)

  1. STS-56 onorbit view of Discovery's, OV-103's, payload bay with ATLAS-2 pallet

    Science.gov (United States)

    1993-01-01

    During STS-56, the Atmospheric Laboratory for Applications and Science 2 (ATLAS-2) unpressurized spacelab pallet and its experiment equipment was documented in the payload bay (PLB) of Discovery, Orbiter Vehicle (OV) 103. ATLAS-2 equipment and instruments include: port conical scan sensor (cylindrical-shaped device at far right); the millimeter-wave atmospheric sounder (MAS) antenna (dish-shaped device at pallet center); the starboard conical scan sensor (small cylinder at far left); and the atmospheric trace module spectroscopy (ATMOS) (box behind conical sensor at far left). Smaller ATLAS-2 instruments located in the center of the pallet include (left to right): Active Cavity Radiometer Irradiance Monitor (ACRIM or ACR); Solar Constant Instrument (SOLCON); Solar Spectrum Instrument (SOLSPEC); and MAS (large box just below antenna). The Shuttle Pointed Autonomous Research Tool for Astronomy 201 (SPARTAN-201) is missing as it was in the midst of separation from OV-103 when the photo wa

  2. STS-56 Discovery, OV-103, payload bay (PLB) with ATLAS-2 pallet and SPARTAN-201

    Science.gov (United States)

    1993-01-01

    During STS-56 with Discovery, Orbiter Vehicle (OV) 103, in an atmospheric monitoring attitude, the Atmospheric Laboratory for Applications and Science 2 (ATLAS-2) unpressurized spacelab pallet and the mission peculiar support structure (MPESS)-mounted Shuttle Pointed Autonomous Research Tool for Astronomy 201 (SPARTAN-201) are visible in the payload bay (PLB). ATLAS-2 equipment and instruments include: the igloo (center foreground, only the top visible); the inverters and pump package (far right); port conical scan sensor (adjacent to pump package at far right); the millimeter-wave atmospheric sounder (MAS) antenna (dish-shaped device at pallet center) with ATMOS recorder underneath it; the starboard conical scan sensor (small cylinder at far left); and the atmospheric trace module spectroscopy (ATMOS) (box behind conical sensor at far left). Smaller ATLAS-2 instruments located in the center of the pallet include (left to right): Active Cavity Radiometer Irradiance Monitor (ACRIM or AC

  3. Electrical tests of silicon detector modules for the ATLAS experiment and a study of the discovery potential of the $t\\overline{t}H, H \\to W^{+}W^{-}$ process

    CERN Document Server

    Ludwig, Inga

    2011-01-01

    The first part of this thesis was a contribution to the construction of the ATLAS Semiconductor Tracking detector (SCT). About 200 SCT endcap modules were assembled at the University of Freiburg. Before installation in the experiment, each module was subject to thorough testing in order to ensure their functionality within the ATLAS specifications. A large part of these tests concerned the electrical functionality of the readout electronics and the bias current behaviour of the sensors. The responsibility for the electrical characterization of the Freiburg modules was part of this thesis. To be suited for the analysis of physics processes, the signals measured in the detector need to be transferred into particle four-momenta, requiring the reconstruction and identification of different particle types. This thesis contributes to the physics object identification by a study of methods to separate isolated electrons from real electron background produced in the decays of heavy quarks. A standard set of four disc...

  4. ATLAS discovery of bright nuclear transient flux in NGC4708 : ATLAS16bdg

    Science.gov (United States)

    Tonry, J.; Denneau, L.; Stalder, B.; Heinze, A.; Sherstyuk, A.; Rest, A.; Smith, K. W.; Smartt, S. J.; Wright, D.; Young, D. R.; Huber, M.; Chambers, K. C.; Flewelling, H.; Willman, M.; Primak, N.; Schultz, A.; Gibson, B.; Magnier, E.; Waters, C.; Tonry, J.; Wainscoat, R. J.

    2016-06-01

    ATLAS is a twin 0.5m telescope system on Haleakala and Mauna Loa. The first unit is operational on Haleakala and is robotically surveying the sky. Two filters are used, cyan and orange (denoted c and o, all mags in AB system), more information is on http://www.fallingstar.com.

  5. ATLAS discovery of a probable SN in 2MASX J17093078+2136344 (ATLAS16bcb)

    Science.gov (United States)

    Tonry, J.; Denneau, L.; Stalder, B.; Heinze, A.; Sherstyuk, A.; Rest, A.; Smith, K. W.; Smartt, S. J.

    2016-06-01

    ATLAS is a twin 0.5m telescope system on Haleakala and Mauna Loa. The first unit is operational on Haleakala and is robotically surveying the sky. Two filters are used, cyan and orange (denoted c and o, all mags in AB system), more information is on http://www.fallingstar.com.

  6. ATLAS distributed computing operation shift teams experience during the discovery year and beginning of the long shutdown 1

    International Nuclear Information System (INIS)

    ATLAS Distributed Computing Operation Shifts evolve to meet new requirements. New monitoring tools as well as operational changes lead to modifications in organization of shifts. In this paper we describe the structure of shifts, the roles of different shifts in ATLAS computing grid operation, the influence of a Higgs-like particle discovery on shift operation, the achievements in monitoring and automation that allowed extra focus on the experiment priority tasks, and the influence of the Long Shutdown 1 and operational changes related to the no beam period.

  7. Studies with Muons in ATLAS: TileCal Level-2 Trigger and MSSM Higgs Discovery Reach

    CERN Document Server

    Ruiz Martínez, A; Valls Ferrer, J A

    2009-01-01

    This thesis was carried out in the years previous to the LHC start-up, i.e. during the ATLAS detector commissioning phase. It contains an introductory part about the detector and its expected physics performance and two main parts about the development of a Level-2 trigger for muons and a study of the MSSM Higgs discovery reach with simulated data, which are briefly described below. The first part of the thesis is devoted to TileMuId, the muon identication algorithm based on TileCal whose main goal is to be used as a Level-2 trigger of low-$p_{\\text{T}}$ muons. A second version of TileMuId (ROD-based) has been implemented to run in the TileCal ROD DSPs. This involved developments in the DSP firmware and in the Athena framework, described in the document. In addition, studies of the algorithm performance in terms of efficiency and fraction of fakes have been done. Developments and studies to match the TileCal muon candidates with the Inner Detector tracks (provided by ID reconstruction algorithms) have been pe...

  8. EnviroAtlas - Portland, OR - Potential Window Views of Water by Block Group

    Data.gov (United States)

    U.S. Environmental Protection Agency — This EnviroAtlas dataset describes the block group population and the percentage of the block group population that has potential views of water bodies. A potential...

  9. EnviroAtlas - Milwaukee, WI - Potential Window Views of Water by Block Group

    Data.gov (United States)

    U.S. Environmental Protection Agency — This EnviroAtlas dataset describes the block group population and the percentage of the block group population that has potential views of water bodies. A potential...

  10. EnviroAtlas - New Bedford, MA - Potential Window Views of Water by Block Group

    Data.gov (United States)

    U.S. Environmental Protection Agency — This EnviroAtlas dataset describes the block group population and the percentage of the block group population that has potential views of water bodies. A potential...

  11. EnviroAtlas - Fresno, CA - Potential Window Views of Water by Block Group

    Data.gov (United States)

    U.S. Environmental Protection Agency — This EnviroAtlas dataset describes the block group population and the percentage of the block group population that has potential views of water bodies. A potential...

  12. EnviroAtlas - Potentially Restorable Wetlands on Agricultural Land - Contiguous United States

    Data.gov (United States)

    U.S. Environmental Protection Agency — The EnviroAtlas Potentially Restorable Wetlands on Agricultural Land (PRW-Ag) dataset shows potentially restorable wetlands at 30-meter resolution. Beginning two...

  13. EnviroAtlas - Portland, ME - Potential Window Views of Water by Block Group

    Data.gov (United States)

    U.S. Environmental Protection Agency — This EnviroAtlas dataset describes the block group population and the percentage of the block group population that has potential views of water bodies. A potential...

  14. EnviroAtlas - Tampa, FL - Potential Window Views of Water by Block Group

    Data.gov (United States)

    U.S. Environmental Protection Agency — This EnviroAtlas dataset describes the block group population and the percentage of the block group population that has potential views of waterbodies. A potential...

  15. EnviroAtlas - Memphis, TN - Potential Window Views of Water by Block Group

    Data.gov (United States)

    U.S. Environmental Protection Agency — This EnviroAtlas dataset describes the block group population and the percentage of the block group population that has potential views of water bodies. A potential...

  16. EnviroAtlas - New York, NY - Potential Window Views of Water by Block Group

    Data.gov (United States)

    U.S. Environmental Protection Agency — This EnviroAtlas dataset describes the block group population and the percentage of the block group population that has potential views of water bodies. A potential...

  17. EnviroAtlas - Paterson, NJ - Potential Window Views of Water by Block Group

    Data.gov (United States)

    U.S. Environmental Protection Agency — This EnviroAtlas dataset describes the block group population and the percentage of the block group population that has potential views of water bodies. A potential...

  18. EnviroAtlas - Des Moines, IA - Potential Window Views of Water by Block Group

    Data.gov (United States)

    U.S. Environmental Protection Agency — This EnviroAtlas dataset describes the block group population and the percentage of the block group population that has potential views of water bodies. A potential...

  19. EnviroAtlas - Pittsburgh, PA - Potential Window Views of Water by Block Group

    Data.gov (United States)

    U.S. Environmental Protection Agency — This EnviroAtlas dataset describes the block group population and the percentage of the block group population that has potential views of water bodies. A potential...

  20. EnviroAtlas - Green Bay, WI - Potential Window Views of Water by Block Group

    Data.gov (United States)

    U.S. Environmental Protection Agency — This EnviroAtlas dataset describes the block group population and the percentage of the block group population that has potential views of water bodies. A potential...

  1. EnviroAtlas - Austin, TX - Potential Window Views of Water by Block Group

    Data.gov (United States)

    U.S. Environmental Protection Agency — This EnviroAtlas dataset describes the block group population and the percentage of the block group population that has potential views of water bodies. A potential...

  2. EnviroAtlas - Potentially Restorable Wetlands in the Conterminous United States

    Data.gov (United States)

    U.S. Environmental Protection Agency — This EnviroAtlas dataset shows potentially restorable wetlands at 30 meter resolution. Beginning two centuries ago, many wetlands were turned into farm fields or...

  3. EnviroAtlas - Portland, OR - Residents with Potential Window Views of Trees by Block Group

    Data.gov (United States)

    U.S. Environmental Protection Agency — This EnviroAtlas dataset shows the total block group population and the percentage of the block group population that has little access to potential window views of...

  4. EnviroAtlas - Pittsburgh, PA - Residents with Potential Window Views of Trees by Block Group

    Data.gov (United States)

    U.S. Environmental Protection Agency — This EnviroAtlas dataset shows the total block group population and the percentage of the block group population that has little access to potential window views of...

  5. EnviroAtlas - Durham, NC - Residents with Potential Window Views of Trees by Block Group

    Data.gov (United States)

    U.S. Environmental Protection Agency — This EnviroAtlas dataset shows the total block group population and the percentage of the block group population that has little access to potential window views of...

  6. EnviroAtlas - Phoenix, AZ - Residents with Potential Window Views of Trees by Block Group

    Data.gov (United States)

    U.S. Environmental Protection Agency — This EnviroAtlas dataset shows the total block group population and the percentage of the block group population that has little access to potential window views of...

  7. EnviroAtlas - New Bedford, MA - Residents with Potential Window Views of Trees by Block Group

    Data.gov (United States)

    U.S. Environmental Protection Agency — This EnviroAtlas dataset shows the total block group population and the percentage of the block group population that has little access to potential window views of...

  8. EnviroAtlas - Tampa, FL - Residents with Potential Window Views of Trees by Block Group

    Data.gov (United States)

    U.S. Environmental Protection Agency — This EnviroAtlas dataset shows the total block group population and the percentage of the block group population that has little access to potential window views of...

  9. EnviroAtlas - Milwaukee, WI - Residents with Potential Window Views of Trees by Block Group

    Data.gov (United States)

    U.S. Environmental Protection Agency — This EnviroAtlas dataset shows the total block group population and the percentage of the block group population that has little access to potential window views of...

  10. EnviroAtlas - Green Bay, WI - Residents with Potential Window Views of Trees by Block Group

    Data.gov (United States)

    U.S. Environmental Protection Agency — This EnviroAtlas dataset shows the total block group population and the percentage of the block group population that has little access to potential window views of...

  11. EnviroAtlas - Woodbine, IA - Residents with Potential Window Views of Trees by Block Group

    Data.gov (United States)

    U.S. Environmental Protection Agency — This EnviroAtlas dataset shows the total block group population and the percentage of the block group population that has little access to potential window views of...

  12. EnviroAtlas - Memphis, TN - Residents with Minimal Potential Window Views of Trees by Block Group

    Data.gov (United States)

    U.S. Environmental Protection Agency — This EnviroAtlas dataset shows the total block group population and the percentage of the block group population that has little access to potential window views of...

  13. EnviroAtlas - Paterson, NJ - Residents with Potential Window Views of Trees by Block Group

    Data.gov (United States)

    U.S. Environmental Protection Agency — This EnviroAtlas dataset shows the total block group population and the percentage of the block group population that has little access to potential window views of...

  14. EnviroAtlas - Austin, TX - Residents with Minimal Potential Window Views of Trees by Block Group

    Data.gov (United States)

    U.S. Environmental Protection Agency — This EnviroAtlas dataset shows the total block group population and the percentage of the block group population that has little access to potential window views of...

  15. EnviroAtlas - Fresno, CA - Residents with Potential Window Views of Trees by Block Group

    Data.gov (United States)

    U.S. Environmental Protection Agency — This EnviroAtlas dataset shows the total block group population and the percentage of the block group population that has little access to potential window views of...

  16. EnviroAtlas - Portland, ME - Residents with Potential Window Views of Trees by Block Group

    Data.gov (United States)

    U.S. Environmental Protection Agency — This EnviroAtlas dataset shows the total block group population and the percentage of the block group population that has little access to potential window views of...

  17. ATLAS Experiment Brochure

    CERN Multimedia

    Goldfarb, Steven

    2016-01-01

    ATLAS is one of the four major experiments at the Large Hadron Collider at CERN. It is a general-purpose particle physics experiment run by an international collaboration, and is designed to exploit the full discovery potential and the huge range of physics opportunities that the LHC provides.

  18. IMG-ABC: An Atlas of Biosynthetic Gene Clusters to Fuel the Discovery of Novel Secondary Metabolites

    Energy Technology Data Exchange (ETDEWEB)

    Chen, I-Min; Chu, Ken; Ratner, Anna; Palaniappan, Krishna; Huang, Jinghua; Reddy, T. B.K.; Cimermancic, Peter; Fischbach, Michael; Ivanova, Natalia; Markowitz, Victor; Kyrpides, Nikos; Pati, Amrita

    2014-10-28

    In the discovery of secondary metabolites (SMs), large-scale analysis of sequence data is a promising exploration path that remains largely underutilized due to the lack of relevant computational resources. We present IMG-ABC (https://img.jgi.doe.gov/abc/) -- An Atlas of Biosynthetic gene Clusters within the Integrated Microbial Genomes (IMG) system1. IMG-ABC is a rich repository of both validated and predicted biosynthetic clusters (BCs) in cultured isolates, single-cells and metagenomes linked with the SM chemicals they produce and enhanced with focused analysis tools within IMG. The underlying scalable framework enables traversal of phylogenetic dark matter and chemical structure space -- serving as a doorway to a new era in the discovery of novel molecules.

  19. Sensitivity and Discovery Potential of the PROSPECT Experiment

    CERN Document Server

    ,

    2015-01-01

    Measurements of the reactor antineutrino flux and spectrum compared to model predictions have revealed an apparent deficit in the interaction rates of reactor antineutrinos and an unexpected spectral deviation. PROSPECT, the Precision Reactor Oscillation Spectrum measurement, is designed to make a precision measurement of the antineutrino spectrum from a research reactor and search for signs of an eV-scale sterile neutrino. PROSPECT will be located at the High Flux Isotope Reactor (HFIR) at Oak Ridge National Laboratory and make use of a Highly Enriched Uranium reactor for a measurement of the pure U-235 antineutrino spectrum. An absolute measurement of this spectrum will constrain reactor models and improve our understanding of the reactor antineutrino spectrum. Additionally, the planned 3-ton lithium-doped liquid scintillator detector is ideally suited to perform a search for sterile neutrinos. This talk will focus on the sensitivity and discovery potential of PROSPECT and the detector design to achieve the...

  20. ATLAS

    Data.gov (United States)

    Federal Laboratory Consortium — ATLAS is a particle physics experiment at the Large Hadron Collider at CERN, the European Organization for Nuclear Research. Scientists from Brookhaven have played...

  1. Usefulness of brain atlases in neuroradiology: Current status and future potential.

    Science.gov (United States)

    Nowinski, Wieslaw L

    2016-08-01

    Human brain atlases, although prevalent in medical education and stereotactic and functional neurosurgery, are not yet applied practically in neuroradiology. In a step towards introducing brain atlases to neuroradiology, we discuss nine different situations of potential atlas use: (1) to support interpretation of brain scans with clearly visible structures (to increase confidence of non-neuroradiologists); (2) to delineate and label scans of low anatomical content (with indiscernible or poorly visible anatomy); (3) to assist in generating the structured report; (4) to assist in interpreting small deep lesions, since an atlas's anatomical parcellation is higher than that of the interpreted scan; (5) to approximate distorted due to pathology (and unknown to the interpreter) anatomy and label it; (6) to cope with data explosion; (7) to assist in the interpretation of functional scans (to label the activation foci with the underlying anatomy and Brodmann's areas); (8) to support ischemic stroke image handling by means of atlases of anatomy and blood supply territories; and (9) to communicate image interpretation results (diagnosis) to others. The usefulness of the atlas for automatic structure identification, localisation, delineation, labelling and quantification, as well as for reporting and communication, potentially increases the interpreter's efficiency and confidence, as well as expedites image interpretation. PMID:27154190

  2. North African geology: exploration matrix for potential major hydrocarbon discoveries

    Energy Technology Data Exchange (ETDEWEB)

    Kanes, W.H.; O' Connor, T.E.

    1985-02-01

    Based on results and models presented previously, it is possible to consider an exploration matrix that examines the 5 basic exploration parameters: source, reservoir, timing, structure, and seal. This matrix indicates that even those basins that have had marginal exploration successes, including the Paleozoic megabasin and downfaulted Triassic grabens of Morocco, the Cyrenaican platform of Libya, and the Tunisia-Sicily shelf, have untested plays. The exploration matrix also suggests these high-risk areas could change significantly, if one of the 5 basic matrix parameters is upgraded or if adjustments in political or financial risk are made. The Sirte basin and the Gulf of Suez, 2 of the more intensely explored areas, also present attractive matrix prospects, particularly with deeper Nubian beds or with the very shallow Tertiary sections. The Ghadames basin of Libya and Tunisia shows some potential, but its evaluation responds strongly to stratigraphic and external nongeologic matrix variations based on degree of risk exposure to be assumed. Of greatest risk in the matrix are the very deep Moroccan Paleozoic clastic plays and the Jurassic of Sinai. However, recent discoveries may upgrade these untested frontier areas. Based on the matrix generated by the data presented at a North African Petroleum Geology symposium, significant hydrocarbon accumulations are yet to be found. The remaining questions are: where in the matrix does each individual company wish to place its exploration capital and how much should be the risk exposure.

  3. ATLAS

    CERN Multimedia

    2002-01-01

    Barrel and END-CAP Toroids In order to produce a powerful magnetic field to bend the paths of the muons, the ATLAS detector uses an exceptionally large system of air-core toroids arranged outside the calorimeter volumes. The large volume magnetic field has a wide angular coverage and strengths of up to 4.7tesla. The toroids system contains over 100km of superconducting wire and has a design current of 20 500 amperes. (ATLAS brochure: The Technical Challenges)

  4. ATLAS

    CERN Multimedia

    Akhnazarov, V; Canepa, A; Bremer, J; Burckhart, H; Cattai, A; Voss, R; Hervas, L; Kaplon, J; Nessi, M; Werner, P; Ten kate, H; Tyrvainen, H; Vandelli, W; Krasznahorkay, A; Gray, H; Alvarez gonzalez, B; Eifert, T F; Rolando, G; Oide, H; Barak, L; Glatzer, J; Backhaus, M; Schaefer, D M; Maciejewski, J P; Milic, A; Jin, S; Von torne, E; Limbach, C; Medinnis, M J; Gregor, I; Levonian, S; Schmitt, S; Waananen, A; Monnier, E; Muanza, S G; Pralavorio, P; Talby, M; Tiouchichine, E; Tocut, V M; Rybkin, G; Wang, S; Lacour, D; Laforge, B; Ocariz, J H; Bertoli, W; Malaescu, B; Sbarra, C; Yamamoto, A; Sasaki, O; Koriki, T; Hara, K; Da silva gomes, A; Carvalho maneira, J; Marcalo da palma, A; Chekulaev, S; Tikhomirov, V; Snesarev, A; Buzykaev, A; Maslennikov, A; Peleganchuk, S; Sukharev, A; Kaplan, B E; Swiatlowski, M J; Nef, P D; Schnoor, U; Oakham, G F; Ueno, R; Orr, R S; Abouzeid, O; Haug, S; Peng, H; Kus, V; Vitek, M; Temming, K K; Dang, N P; Meier, K; Schultz-coulon, H; Geisler, M P; Sander, H; 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Sadrozinski, H; Lockman, W S; Martinez-mc kinney, G; Goussiou, A; Jones, A; Lie, K; Hasegawa, Y; Olcese, M; Gilewsky, V; Harrison, P F; Janus, M; Spangenberg, M; De, K; Ozturk, N; Pal, A K; Darmora, S; Bullock, D J; Oviawe, O; Derkaoui, J E; Rahal, G; Sircar, A; Frey, A S; Stolte, P; Rosien, N; Zoch, K; Li, L; Schouten, D W; Catinaccio, A; Ciapetti, M; Delruelle, N; Ellis, N; Farthouat, P; Hoecker, A; Klioutchnikova, T; Macina, D; Malyukov, S; Spiwoks, R D; Unal, G P; Vandoni, G; Petersen, B A; Pommes, K; Nairz, A M; Wengler, T; Mladenov, D; Solans sanchez, C A; Lantzsch, K; Schmieden, K; Jakobsen, S; Ritsch, E; Sciuccati, A; Alves dos santos, A M; Ouyang, Q; Zhou, M; Brock, I C; Janssen, J; Katzy, J; Anders, C F; Nilsson, B S; Bazan, A; Di ciaccio, L; Yildizkaya, T; Collot, J; Malek, F; Trocme, B S; Breugnon, P; Godiot, S; Adam bourdarios, C; Coulon, J; Duflot, L; Petroff, P G; Zerwas, D; Lieuvin, M; Calderini, G; Laporte, D; Ocariz, J; Gabrielli, A; Ohska, T K; Kurochkin, Y; Kantserov, V; Vasilyeva, L; Speransky, M; Smirnov, S; Antonov, A; Bulekov, O; Tikhonov, Y; Sargsyan, L; Vardanyan, G; Budick, B; Kocian, M L; Luitz, S; Young, C C; Grenier, P J; Kelsey, M; Black, J E; Kneringer, E; Jussel, P; Horton, A J; Beaudry, J; Chandra, A; Ereditato, A; Topfel, C M; Mathieu, R; Bucci, F; Muenstermann, D; White, R M; He, M; Urban, J; Straka, M; Vrba, V; Schumacher, M; Parzefall, U; Mahboubi, K; Sommer, P O; Koepke, L H; Bethke, S; Moser, H; Wiesmann, M; Walkowiak, W A; Fleck, I J; Martinez-perez, M; Sanchez sanchez, C A; Jorgensen roca, S; Accion garcia, E; Sainz ruiz, C A; Valls ferrer, J A; Amoros vicente, G; Vives torrescasana, R; Ouraou, A; Formica, A; Hassani, S; Watson, M F; Cottin buracchio, G F; Bussey, P J; Saxon, D; Ferrando, J E; Collins-tooth, C L; Hall, D C; Cuhadar donszelmann, T; Dawson, I; Duxfield, R; Argyropoulos, T; Brodet, E; Livneh, R; Shougaev, K; Reinherz, E I; Guttman, N; Beretta, M M; Vilucchi, E; Aloisio, A; Patricelli, S; Caprio, M; Cevenini, F; De vecchi, C; Livan, M; Rimoldi, A; Vercesi, V; Ayad, R; Mastroberardino, A; Ciapetti, G; Luminari, L; Rescigno, M; Santonico, R; Salamon, A; Del papa, C; Kurashige, H; Homma, Y; Tomoto, M; Horii, Y; Sugaya, Y; Hanagaki, K; Bobbink, G; Kluit, P M; Koffeman, E N; Van eijk, B; Lee, H; Eigen, G; Dorholt, O; Strandlie, A; Strzempek, P B; Dita, S; Stoicea, G; Chitan, A; Leven, S S; Moa, T; Brenner, R; Ekelof, T J C; Olshevskiy, A; Roumiantsev, V; Chlachidze, G; Zimine, N; Gusakov, Y; Grigalashvili, N; Mineev, M; Potrap, I; Barashkou, A; Shoukavy, D; Shaykhatdenov, B; Pikelner, A; Gladilin, L; Ammosov, V; Abramov, A; Arik, M; Sahinsoy, M; Uysal, Z; Azizi, K; Hotinli, S C; Zhou, S; Berger, E; Blair, R; Underwood, D G; Einsweiler, K; Garcia-sciveres, M A; Siegrist, J L; Kipnis, I; Dahl, O; Holland, S; Barbaro galtieri, A; Smith, P T; Parua, N; Franklin, M; Mercurio, K M; Tong, B; Pod, E; Cole, S G; Hopkins, W H; Guest, D H; Severini, H; Marsicano, J J; Abbott, B K; Wang, Q; Lissauer, D; Ma, H; Takai, H; Rajagopalan, S; Protopopescu, S D; Snyder, S S; Undrus, A; Popescu, R N; Begel, M A; Blocker, C A; Amelung, C; Mandic, I; Macek, B; Tucker, B H; Citterio, M; Troncon, C; Orestano, D; Taccini, C; Romeo, G L; Dova, M T; Taylor, G N; Gesualdi manhaes, A; Mcpherson, R A; Sobie, R; Taylor, R P; Dolezal, Z; Kodys, P; Slovak, R; Sopko, B; Vacek, V; Sanders, M P; Hertenberger, R; Meineck, C; Becks, K; Kind, P; Sandhoff, M; Cantero garcia, J; De la torre perez, H; Castillo gimenez, V; Ros, E; Hernandez jimenez, Y; Chadelas, R; Santoni, C; Washbrook, A J; O'brien, B J; Wynne, B M; Mehta, A; Vossebeld, J H; Landon, M; Teixeira dias castanheira, M; Cerrito, L; Keates, J R; Fassouliotis, D; Chardalas, M; Manousos, A; Grachev, V; Seliverstov, D; Sedykh, E; Cakir, O; Ciftci, R; Edson, W; Prell, S A; Rosati, M; Stroman, T; Jiang, H; Neal, H A; Li, X; Gan, K K; Smith, D S; Kruse, M C; Ko, B R; Leung fook cheong, A M; Cole, B; Angerami, A R; Greene, Z S; Kroll, J I; Van berg, R P; Forbush, D A; Lubatti, H; Raisher, J; Shupe, M A; Wolin, S; Oshita, H; Gaudio, G; Das, R; Konig, A C; Croft, V A; Harvey, A; Maaroufi, F; Melo, I; Greenwood jr, Z D; Shabalina, E; Mchedlidze, G; Drechsler, E; Rieger, J K; Blackston, M; Colombo, T

    2002-01-01

    % ATLAS \\\\ \\\\ ATLAS is a general-purpose experiment for recording proton-proton collisions at LHC. The ATLAS collaboration consists of 144 participating institutions (June 1998) with more than 1750~physicists and engineers (700 from non-Member States). The detector design has been optimized to cover the largest possible range of LHC physics: searches for Higgs bosons and alternative schemes for the spontaneous symmetry-breaking mechanism; searches for supersymmetric particles, new gauge bosons, leptoquarks, and quark and lepton compositeness indicating extensions to the Standard Model and new physics beyond it; studies of the origin of CP violation via high-precision measurements of CP-violating B-decays; high-precision measurements of the third quark family such as the top-quark mass and decay properties, rare decays of B-hadrons, spectroscopy of rare B-hadrons, and $ B ^0 _{s} $-mixing. \\\\ \\\\The ATLAS dectector, shown in the Figure includes an inner tracking detector inside a 2~T~solenoid providing an axial...

  5. Photons in ATLAS from Run1 to Run2

    CERN Document Server

    Levchenko, Mikhail; The ATLAS collaboration

    2015-01-01

    The performance of the reconstruction and identification of photons with the ATLAS detector at the LHC is a key component to realize the ATLAS full physics potential, both in the searches for new physics and in precision measurements. For instance, photons played a critical role in the discovery of a Higgs boson, announced by the ATLAS Collaboration in 2012, and in the measurement of its properties. These proceedings present a description of the algorithms used for the reconstruction and identification of photons with the ATLAS detector, as well as results from the measurements of their efficiencies in pp collisions.

  6. Potential optimisation of the ATLAS reconstruction geometry description.

    CERN Document Server

    Andrews, Holly

    2015-01-01

    The offline reconstruction software of high energy physics experiments often uses a simplified geometry and material model in order to speed up the process of material effect integration within the event reconstruction. This geometry model is also often used for fast simulation purposes, in ATLAS for the fast track simulation FATRAS. As part of a 12 week summer project undertaken at CERN, the use of material property maps within the FATRAS software were explored. A new material properties map was developed that relies on less data storage, allowing for a higher level of geometric properties to be stored over a greater range of the geometry. This is done by compressing to an acceptable memory level. A new manipulator tool was also created that is able to correct the quantity of material assigned to individual layers within the tracking geometry via an array of scaling factors for each layer, which leads to more accuracy in reconstruction parameters. This new tool has been developed within the ATLAS offline fra...

  7. Discovery of two new bright magnetic B stars: i Car and Atlas

    Science.gov (United States)

    Neiner, Coralie; Buysschaert, Bram; Oksala, Mary E.; Blazère, Aurore

    2015-11-01

    The BRITE (BRIght Target Explorer) constellation of nanosatellites performs seismology of bright stars via high-precision photometry. In this context, we initiated a high-resolution, high signal-to-noise, high-sensitivity, spectropolarimetric survey of all stars brighter than V = 4. The goal of this survey is to detect new bright magnetic stars and provide prime targets for both detailed magnetic studies and asteroseismology with BRITE. Circularly polarized spectra were acquired with Narval at TBL (Bernard Lyot Telescope, France) and HARPSpol at ESO (European Southern Observatory) in La Silla (Chile). We discovered two new magnetic B stars: the B3V star i Car and the B8V component of the binary star Atlas. Each star was observed twice to confirm the magnetic detections and check for variability. These bright magnetic B stars are prime targets for asteroseismology and for flux-demanding techniques, such as interferometry.

  8. Discovery of two new bright magnetic B stars: i Car and Atlas

    CERN Document Server

    Neiner, Coralie; Oksala, Mary E; Blazere, Aurore

    2015-01-01

    The BRITE (BRIght Target Explorer) constellation of nano-satellites performs seismology of bright stars via high precision photometry. In this context, we initiated a high resolution, high signal-to-noise, high sensitivity, spectropolarimetric survey of all stars brighter than V=4. The goal of this survey is to detect new bright magnetic stars and provide prime targets for both detailed magnetic studies and asteroseismology with BRITE. Circularly polarised spectra were acquired with Narval at TBL (France) and HarpsPol at ESO in La Silla (Chile). We discovered two new magnetic B stars: the B3V star i Car and the B8V component of the binary star Atlas. Each star was observed twice to confirm the magnetic detections and check for variability. These bright magnetic B stars are prime targets for asteroseismology and for flux-demanding techniques, such as interferometry.

  9. At the survey limits: discovery of the Aquarius 2 dwarf galaxy in the VST ATLAS and the SDSS data

    CERN Document Server

    Torrealba, G; Belokurov, V; Irwin, M; Collins, M; Spencer, M; Ibata, R; Mateo, M; Bonaca, A; Jethwa, P

    2016-01-01

    We announce the discovery of the Aquarius~2 dwarf galaxy, a new distant satellite of the Milky Way, detected on the fringes of the VST ATLAS and the SDSS surveys. The object was originally identified as an overdensity of Red Giant Branch stars, but chosen for subsequent follow-up based on the presence of a strong Blue Horizontal Branch, which was also used to measure its distance of $\\sim 110$ kpc. Using deeper imaging from the IMACS camera on the 6.5m Baade and spectroscopy with DEIMOS on Keck, we measured the satellite's half-light radius $5.1\\pm 0.8$ arcmin, or $\\sim 160$ pc at this distance, and its stellar velocity dispersion of $5.4^{+3.4}_{-0.9}$ km s$^{-1}$. With $\\mu=30.4$ mag arcsec$^{-2}$ and $M_V=-4.2$, the new satellite lies close to two important detection limits: one in surface brightness; and one in luminosity at a given distance, thereby making Aquarius~2 one of the hardest dwarfs to find.

  10. At the survey limits: discovery of the Aquarius 2 dwarf galaxy in the VST ATLAS and the SDSS data

    Science.gov (United States)

    Torrealba, G.; Koposov, S. E.; Belokurov, V.; Irwin, M.; Collins, M.; Spencer, M.; Ibata, R.; Mateo, M.; Bonaca, A.; Jethwa, P.

    2016-08-01

    We announce the discovery of the Aquarius 2 dwarf galaxy, a new distant satellite of the Milky Way, detected on the fringes of the VST ATLAS and the SDSS surveys. The object was originally identified as an overdensity of Red Giant Branch stars, but chosen for subsequent follow-up based on the presence of a strong Blue Horizontal Branch, which was also used to measure its distance of ˜110 kpc. Using deeper imaging from the IMACS camera on the 6.5m Baade and spectroscopy with DEIMOS on Keck, we measured the satellite's half-light radius 5.1 ± 0.8 arcmin, or ˜160 pc at this distance, and its stellar velocity dispersion of 5.4^{+3.4}_{-0.9} km s-1. With μ = 30.2 mag arcsec-2 and MV = -4.36, the new satellite lies close to two important detection limits: one in surface brightness; and one in luminosity at a given distance, thereby making Aquarius 2 one of the hardest dwarfs to find.

  11. Charged Higgs boson searches and SemiConductor Tracker commissioning for the ATLAS experiment

    OpenAIRE

    Mohn, Bjarte Alsaker

    2007-01-01

    The ATLAS (A Toroidal Lhc ApparatuS) experiment is one of four major experiments presently being installed at the upcoming Large Hadron Collider (LHC) at the European Centre for Nuclear Research (CERN) outside Geneva. In this thesis we present work done on both the simulation of the ATLAS physics potential for a charged Higgs boson and the construction of the Semiconductor Tracker (SCT) - a subdetector within the ATLAS Inner Detector. The discovery of a charged Higgs boson w...

  12. EnviroAtlas - New York, NY - Residents with Minimal Potential Window Views of Trees by Block Group

    Data.gov (United States)

    U.S. Environmental Protection Agency — This EnviroAtlas dataset shows the total block group population and the percentage of the block group population that has little access to potential window views of...

  13. EnviroAtlas - Des Moines, IA - Residents with Minimal Potential Window Views of Trees by Block Group

    Data.gov (United States)

    U.S. Environmental Protection Agency — This EnviroAtlas dataset shows the total block group population and the percentage of the block group population that has little access to potential window views of...

  14. EnviroAtlas - Potentially Restorable Wetlands in the Conterminous United States Web Service

    Data.gov (United States)

    U.S. Environmental Protection Agency — This EnviroAtlas web service supports research and online mapping activities related to EnviroAtlas (https://www.epa.gov/enviroatlas). This EnviroAtlas dataset...

  15. Virtual Visit to the ATLAS Control Room by Open Discovery Space webinar in Europe

    CERN Document Server

    2013-01-01

    Open Discovery Space (ODS) is a socially-powered and multilingual open learning infrastructure to boost the adoption of eLearning resources. ODS brings millions of educational resources directly into school classrooms. A key part of planning engaging lessons is access to high-quality, trustworthy teaching content. The platform empowers teachers by helping them build their schools` digital libraries, join lively communities of peers to share best practices, and connect their schools virtually with the world`s best research centres, museums and libraries.

  16. Neural crest stem cells: discovery, properties and potential for therapy

    Institute of Scientific and Technical Information of China (English)

    Annita Achilleos; Paul A Trainor

    2012-01-01

    Neural crest (NC) cells are a migratory cell population synonymous with vertebrate evolution.They generate a wide variety of cell and tissue types during embryonic and adult development including cartilage and bone,connective tissue,pigment and endocrine cells as well as neurons and glia amongst many others.Such incredible lineage potential combined with a limited capacity for self-renewal,which persists even into adult life,demonstrates that NC cells bear the key hallmarks of stem and progenitor cells.In this review,we describe the identification,characterization and isolation of NC stem and progenitor cells from different tissues in both embryo and adult organisms.We discuss their specific properties and their potential application in cell-based tissue and disease-specific repair.

  17. Natural Products Towards the Discovery of Potential Future Antithrombotic Drugs.

    Science.gov (United States)

    Islam, Md Asiful; Alam, Fahmida; Khalil, Md Ibrahim; Sasongko, Teguh Haryo; Gan, Siew Hua

    2016-01-01

    Globally, thrombosis-associated disorders are one of the main contributors to fatalities. Besides genetic influences, there are some acquired and environmental risk factors dominating thrombotic diseases. Although standard regimens have been used for a long time, many side effects still occur which can be life threatening. Therefore, natural products are good alternatives. Although the quest for antithrombotic natural products came to light only since the end of last century, in the last two decades, a considerable number of natural products showing antithrombotic activities (antiplatelet, anticoagulant and fibrinolytic) with no or minimal side effects have been reported. In this review, several natural products used as antithrombotic agents including medicinal plants, vegetables, fruits, spices and edible mushrooms which have been discovered in the last 15 years and their target sites (thrombogenic components, factors and thrombotic pathways) are described. In addition, the side effects, limitations and interactions of standard regimens with natural products are also discussed. The active compounds could serve as potential sources for future research on antithrombotic drug development. As a future direction, more advanced researches (in quest of the target cofactor or component involved in antithrombotic pathways) are warranted for the development of potential natural antithrombotic medications (alone or combined with standard regimens) to ensure maximum safety and efficacy. PMID:26951101

  18. Particle physics discovery potential using dark matter detectors

    International Nuclear Information System (INIS)

    Many of the present directions suggested for going ''beyond the Standard Model'' show promise for tests utilizing astrophysical sources. Some astrophysical puzzles suggest particle physics solutions requiring new, unconventional particles. In order to capitalize on these opportunities for progress in particle physics new detection techniques are required. Present technology has already permitted some important tests but the technology is near its limit. Intense activity is underway particularly in the area of cryogenic detectors. These developments have created an exciting new frontier at the intersection of condensed matter, astrophysics and particle physics. The nature of this frontier and its implications for progress in particle physics and its complementarity to the SSC potential are emphasized. Examples of dark matter and solar neutrino experiments are used to illustrate. 59 refs., 3 figs., 2 tabs

  19. Intrinsically Unstructured Proteins: Potential Targets for Drug Discovery

    Directory of Open Access Journals (Sweden)

    Pathan Salma

    2009-01-01

    Full Text Available Problem statement: The function of a protein is dependent on its three-dimensional structure. However, numerous proteins lacking intrinsic globular 3D structure under physiological conditions had been recognized. These proteins are frequently involved in some of the most critical cellular control mechanisms and it appears that their rapid turnover, aided by their unstructured nature in the unbound state, provides a level of control that allows rapid and accurate responses of the cell to changing environmental conditions. Approach: A significant number of proteins known to be involved in protein deposition disorders were now considered to Be Intrinsically Unstructured Proteins (IUPs. For example, Aß peptide and tau protein in Alzheimer’s disease, PrP in Prion’s disease and a-Synuclein in Parkinson’s disease. The disorder of intrinsically unstructured proteins (IUP's was crucial to their functions. They may adopt defined but extended structures when bound to cognate ligands. Their amino acid compositions were less hydrophobic than those of soluble proteins. They lack hydrophobic cores and hence did not become insoluble when heated. About 40% of eukaryotic proteins had at least one long (>50 residues disordered region. Roughly 10% of proteins in various genomes had been predicted to be fully disordered. Presently over 100 IUP's had been identified; none are enzymes. Obviously, IUP's were greatly underrepresented in the Protein Data Bank, although there were few cases of an IUP bound to a folded (intrinsically structured protein. Results: The five functional categories for intrinsically unstructured proteins and domains were entropic chains (bristles to ensure spacing, springs, flexible spacers/linkers, effectors (inhibitors and disassemblers, scavengers, assemblers and display sites. These IUPs could serve as potential targets for Structure Based Drug Design (SBDD which stress on the transition

  20. The Standard Model Higgs : Discovery Potentials and Branching Fraction Measurements at the NLC

    OpenAIRE

    Sachwitz, M.; Schreiber, H. J.; Shichanin, S.

    1997-01-01

    We discuss discovery potentials for a 140 GeV Standard Model Higgs boson produced in e+e- collisions at 360 GeV, including all potential irreducible and reducible background contributions. In the second part of the study, we estimate the uncertainties expected for the branching fractions of the Higgs into bb-bar, tau+tau-, WW* and into cc-bar+gg including a realistic error estimation of the inclusive bremsstrahlung Higgs production cross section.

  1. Overview of recent ATLAS results

    CERN Document Server

    Nikolic-Audit, Irena; The ATLAS collaboration

    2013-01-01

    The ATLAS experiment at the LHC collider has been successfully taking data since the end of 2009 in proton-proton collisions at center of mass energies of 7 and 8 TeV, and in heavy ion collisions. The ATLAS detector has been designed to cover a wide range of physics topics, from the search for the Higgs boson (which will be covered in a separate contribution), precision measurements of Standard Model physics, heavy flavor physics, and to maximize the potential for the discovery of new physics. In this talk, some of the most important recent ATLAS results will be given for the Standard Model measurements, the searches for supersymetry and exotica and for the heavy ion results.

  2. Analysis of Mount Atlas mastic smoke: a potential food preservative.

    Science.gov (United States)

    Mohagheghzadeh, Abdolali; Faridi, Pouya; Ghasemi, Younes

    2010-09-01

    Pistacia terebinthus L. smoke has been used traditionally in Iran as disinfectant and air purifier. Smoke was collected by a simple method, and the chemical constituents and antimicrobial activity of the smoke were analyzed. The chemical constituents of the smoke were alpha-pinene (65.1%), limonene (11.5%) and allo-ocimene (2.8%). The non polar phase of smoke noticeably inhibited the growth of different microorganisms. MIC test shows that non polar fraction of smoke can inhibit the growth of some bacteria. The results indicating that the properties of the smoke as a flavoring and preservative agent could be a potential subject for future studies.

  3. Metagenomics and novel gene discovery: promise and potential for novel therapeutics.

    Science.gov (United States)

    Culligan, Eamonn P; Sleator, Roy D; Marchesi, Julian R; Hill, Colin

    2014-04-01

    Metagenomics provides a means of assessing the total genetic pool of all the microbes in a particular environment, in a culture-independent manner. It has revealed unprecedented diversity in microbial community composition, which is further reflected in the encoded functional diversity of the genomes, a large proportion of which consists of novel genes. Herein, we review both sequence-based and functional metagenomic methods to uncover novel genes and outline some of the associated problems of each type of approach, as well as potential solutions. Furthermore, we discuss the potential for metagenomic biotherapeutic discovery, with a particular focus on the human gut microbiome and finally, we outline how the discovery of novel genes may be used to create bioengineered probiotics.

  4. An evaluation of the potential of GPUs to accelerate tracking algorithms for the ATLAS trigger

    CERN Document Server

    Baines, JTM; The ATLAS collaboration; Emeliyanov, D; Howard, JR; Kama, S; Washbrook, AJ; Wynne, BM

    2014-01-01

    The potential of GPUs has been evaluated as a possible way to accelerate trigger algorithms for the ATLAS experiment located at the Large Hadron Collider (LHC). During LHC Run-1 ATLAS employed a three-level trigger system to progressively reduce the LHC collision rate of 20 MHz to a storage rate of about 600 Hz for offline processing. Reconstruction of charged particles trajectories through the Inner Detector (ID) was performed at the second (L2) and third (EF) trigger levels. The ID contains pixel, silicon strip (SCT) and straw-tube technologies. Prior to tracking, data-preparation algorithms processed the ID raw data producing measurements of the track position at each detector layer. The data-preparation and tracking consumed almost three-quarters of the total L2 CPU resources during 2012 data-taking. Detailed performance studies of a CUDA™ implementation of the L2 pixel and SCT data-preparation and tracking algorithms running on a Nvidia® Tesla C2050 GPU have shown a speed-up by a factor of 12 for the ...

  5. Discovery potential for heavy t-tbar resonances in dilepton+jets final states

    CERN Document Server

    Iashvili, Ia; Kharchilava, Avto; Prosper, Harrison B

    2013-01-01

    We examine the prospects for probing heavy top quark-antiquark (t-tbar) resonances at the upgraded LHC in pp collisions at $\\root_s = 14 TeV. Heavy t-tbar resonances (Z' bosons) are predicted by several theories that go beyond the standard model. We consider scenarios in which each top quark decays leptonically, either to an electron or a muon, and the data sets correspond to integrated luminosities of \\int L dt = 300 /fb and \\int L dt = 3000 /fb. We present the expected 5-sigma discovery potential for a Z' resonance as well as the expected upper limits at 95% C.L. on the Z' production cross section and mass in the absence of a discovery.

  6. Prospect for the Higgs searches with the ATLAS detector

    CERN Document Server

    Richter-Was, E

    2009-01-01

    The investigation of the electroweak symmetry breaking is one of the primary tasks of the experiments at the CERN Large Hadron Collider (LHC). The potential of the ATLAS experiment for the discovery of the Higgs boson(s) in Standard Model and Minimal Supersymmetric Standard Model is presented, with emphasis on studies which have been completed recently.

  7. Chemical analyses of wasp-associated streptomyces bacteria reveal a prolific potential for natural products discovery

    DEFF Research Database (Denmark)

    Poulsen, Michael; Oh, Dong-Chan; Clardy, Jon;

    2011-01-01

    Identifying new sources for small molecule discovery is necessary to help mitigate the continuous emergence of antibiotic-resistance in pathogenic microbes. Recent studies indicate that one potentially rich source of novel natural products is Actinobacterial symbionts associated with social...... of these isolates identified 11 distinct and structurally diverse secondary metabolites, including a novel polyunsaturated and polyoxygenated macrocyclic lactam, which we name sceliphrolactam. By pairing the 15 Streptomyces strains against a collection of fungi and bacteria, we document their antifungal...... and antibacterial activity. The prevalence and anti-microbial properties of Actinobacteria associated with these two solitary wasp species suggest the potential role of these Streptomyces as antibiotic-producing symbionts, potentially helping defend their wasp hosts from pathogenic microbes. Finding...

  8. Higgs Discovery Movie

    CERN Multimedia

    2014-01-01

    The ATLAS & CMS Experiments Celebrate the 2nd Anniversary of the Discovery of the Higgs boson. Here, are some images of the path from LHC startup to Nobel Prize, featuring a musical composition by Roger Zare, performed by the Donald Sinta Quartet, called “LHC”. Happy Discovery Day!

  9. Radiotracer properties determined by high performance liquid chromatography: a potential tool for brain radiotracer discovery

    International Nuclear Information System (INIS)

    Introduction: Previously, development of novel brain radiotracers has largely relied on simple screening tools. Improved selection methods at the early stages of radiotracer discovery and an increased understanding of the relationships between in vitro physicochemical and in vivo radiotracer properties are needed. We investigated if high performance liquid chromatography (HPLC) methodologies could provide criteria for lead candidate selection by comparing HPLC measurements with radiotracer properties in humans. Methods: Ten molecules, previously used as radiotracers in humans, were analysed to obtain the following measures: partition coefficient (Log P); permeability (Pm); percentage of plasma protein binding (%PPB); and membrane partition coefficient (Km). Relationships between brain entry measurements (Log P, Pm and %PPB) and in vivo brain percentage injected dose (%ID); and Km and specific binding in vivo (BPND) were investigated. Log P values obtained using in silico packages and flask methods were compared with Log P values obtained using HPLC. Results: The modelled associations with %ID were stronger for %PPB (r2=0.65) and Pm (r2=0.77) than for Log P (r2=0.47) while 86% of BPND variance was explained by Km. Log P values were variable dependant on the methodology used. Conclusions: Log P should not be relied upon as a predictor of blood-brain barrier penetration during brain radiotracer discovery. HPLC measurements of permeability, %PPB and membrane interactions may be potentially useful in predicting in vivo performance and hence allow evaluation and ranking of compound libraries for the selection of lead radiotracer candidates at early stages of radiotracer discovery.

  10. Atlas of the Colombian coal, Potential map and rank: Map 5-09

    International Nuclear Information System (INIS)

    With the presentation of the Atlas of Coal to scale 1:500.000, it is sought to show to big features the location of the different areas with coal in Colombia, associating with the geologic units, the potential and the range. In the Map 5-09, the formations that include the coal are defined as Umir, Guaduas, Limbo, (Los Cuervos), San Fernando, (Carbonera), defined as Kst, Ksgt and Pgt. For the potential an arbitrary scale settled down, in the following way: in the first place bigger to 1000 million tons; between 1000 and 100; between 100 and 10 and lastly smaller to 10 million tons. These figures are represented in the map by triangles with colors that they are equal before to the figures mentioned. Keeping in mind the scale, it was opted to report the potential in the category of the hypothetical resources; when the resources or reserves are established, they are also reported. As for the range, in the map it is indicated by means of symbols that should be taken as a domain or tendency of the coal in each area in general. The the coal rank understood as the transformation that has reached along the geologic evolution is what is mentioned as anthracitic coal, semi-anthracitic, bituminous low in volatile, bituminous middle in volatile, bituminous high in volatile A, B and C, sub-bituminous and lastly the lignite. For each map are mentioned that there are determined

  11. An overview of recent ATLAS results

    CERN Document Server

    Nikolic-Audit, Irena; The ATLAS collaboration

    2013-01-01

    The ATLAS experiment at the LHC collider has been successfully taking data since the end of 2009, both in proton-proton collisions at center of mass energies of 7 and 8 TeV, and in heavy ion collisions. The ATLAS detector has been designed to cover a wide range of physics topics, from the search for the Higgs boson, precision measurements of Standard Model physics, heavy flavor physics, and to maximize the potential for the discovery of new physics. In this presentation, some of the most important recent ATLAS results will be given for the Standard Model measurements, for the searches for supersymmetry and exotica, and for the heavy ion results. All of the results concerning the properties of the newly discovered Higgs boson are presented in a separate contribution by IlyaTsukerman \\cite{higgs} in these proceedings.

  12. Fly pupae and puparia as potential contaminants of forensic entomology samples from sites of body discovery.

    Science.gov (United States)

    Archer, M S; Elgar, M A; Briggs, C A; Ranson, D L

    2006-11-01

    Fly pupae and puparia may contaminate forensic entomology samples at death scenes if they have originated not from human remains but from animal carcasses or other decomposing organic material. These contaminants may erroneously lengthen post-mortem interval estimates if no pupae or puparia are genuinely associated with the body. Three forensic entomology case studies are presented, in which contamination either occurred or was suspected. In the first case, blow fly puparia collected near the body were detected as contaminants because the species was inactive both when the body was found and when the deceased was last sighted reliably. The second case illustrates that contamination may be suspected at particularly squalid death scenes because of the likely presence of carcasses or organic material. The third case involves the presence at the body discovery site of numerous potentially contaminating animal carcasses. Soil samples were taken along transects to show that pupae and puparia were clustered around their probable sources.

  13. Augmenting Collider Searches and Enhancing Discovery Potentials through Stochastic Jet Grooming

    CERN Document Server

    Roy, Tuhin S

    2016-01-01

    The jet Trimming procedure has been demonstrated to greatly improve event reconstruction in hadron collisions, by mitigating contamination due initial state radiation, multiple interactions, and event pileup. Meanwhile, Qjets -- a nondeterministic approach to tree-based jet substructure has been shown to be a powerful technique in decreasing random statistical fluctuations, yielding significant effective luminosity improvements. This manifests through an improvement in the significance $S/\\delta B$, relative to conventional methods. Qjets also provide novel observables in many cases, like mass-volatility, that could be used to further discriminate between signal and background events. The statistical robustness and volatility observables, for tagging, are obtained simultaneously. We explore here a combination of the two techniques, and demonstrate that significant enhancements in discovery potentials may be obtained in non-trivial ways. We will illustrate this by considering a diboson resonance analysis as a ...

  14. Diffraction and Forward Physics in ATLAS: results and perspectives

    CERN Document Server

    Bruschi, M; The ATLAS collaboration

    2014-01-01

    The present and future potential of ATLAS for diffraction and forward physics is presented. As recent results the rapidity gap cross section and elastic and total pp cross sections are reported. The phase 1 upgrade project AFP is presented and it is shown how it will complement the ALFA acceptance for diffractive physics in measurements taken with beta*=90m. Moreover, the AFP detector will guarantee good acceptance on diffractive events also with normal running conditions optics allowing not only to improve the ATLAS detector performances, but also being fundamental for potential discoveries (for instance, extra dimensions) in case the high luminosity program will be feasible.

  15. Diffraction and Forward Physics in ATLAS: results and perspectives

    CERN Document Server

    Bruschi, Marco; The ATLAS collaboration

    2015-01-01

    The present and future potential of ATLAS for diffraction and forward physics is presented. As recent results the rapidity gap cross section and elastic and total pp cross sections are reported. The upgrade project AFP is presented and it is shown how it will complement the ALFA acceptance for diffractive physics in measurements taken with \\(\\beta^{*}\\)=90 m LHC\\ beam optics. Moreover, the AFP detector will guarantee good acceptance on diffractive events also with normal running conditions optics allowing not only to improve the ATLAS detector performances, but also being fundamental for potential discoveries (for instance, extra dimensions) in case the high luminosity program will be feasible.

  16. EnviroAtlas - Potential Evapotranspiration 1950 - 2099 for the Conterminous United States

    Data.gov (United States)

    U.S. Environmental Protection Agency — The EnviroAtlas Climate Scenarios were generated from NASA Earth Exchange (NEX) Downscaled Climate Projections (NEX-DCP30) ensemble averages (the average of over 30...

  17. Improving the discovery potential of charged Higgs bosons at the Tevatron and large hadron collider

    Indian Academy of Sciences (India)

    Stefano Moretti

    2003-02-01

    We outline several improvements to the experimental analyses carried out at Tevatron (Run 2) or simulated in view of the large hadron collider (LHC) that could increase the scope of CDF/D0 and ATLAS/CMS in detecting charged Higgs bosons.

  18. Chemical analyses of wasp-associated streptomyces bacteria reveal a prolific potential for natural products discovery.

    Directory of Open Access Journals (Sweden)

    Michael Poulsen

    Full Text Available Identifying new sources for small molecule discovery is necessary to help mitigate the continuous emergence of antibiotic-resistance in pathogenic microbes. Recent studies indicate that one potentially rich source of novel natural products is Actinobacterial symbionts associated with social and solitary Hymenoptera. Here we test this possibility by examining two species of solitary mud dauber wasps, Sceliphron caementarium and Chalybion californicum. We performed enrichment isolations from 33 wasps and obtained more than 200 isolates of Streptomyces Actinobacteria. Chemical analyses of 15 of these isolates identified 11 distinct and structurally diverse secondary metabolites, including a novel polyunsaturated and polyoxygenated macrocyclic lactam, which we name sceliphrolactam. By pairing the 15 Streptomyces strains against a collection of fungi and bacteria, we document their antifungal and antibacterial activity. The prevalence and anti-microbial properties of Actinobacteria associated with these two solitary wasp species suggest the potential role of these Streptomyces as antibiotic-producing symbionts, potentially helping defend their wasp hosts from pathogenic microbes. Finding phylogenetically diverse and chemically prolific Actinobacteria from solitary wasps suggests that insect-associated Actinobacteria can provide a valuable source of novel natural products of pharmaceutical interest.

  19. Virtual target screening to rapidly identify potential protein targets of natural products in drug discovery

    Directory of Open Access Journals (Sweden)

    Yuri Pevzner

    2014-05-01

    Full Text Available Inherent biological viability and diversity of natural products make them a potentially rich source for new therapeutics. However, identification of bioactive compounds with desired therapeutic effects and identification of their protein targets is a laborious, expensive process. Extracts from organism samples may show desired activity in phenotypic assays but specific bioactive compounds must be isolated through further separation methods and protein targets must be identified by more specific phenotypic and in vitro experimental assays. Still, questions remain as to whether all relevant protein targets for a compound have been identified. The desire is to understand breadth of purposing for the compound to maximize its use and intellectual property, and to avoid further development of compounds with insurmountable adverse effects. Previously we developed a Virtual Target Screening system that computationally screens one or more compounds against a collection of virtual protein structures. By scoring each compound-protein interaction, we can compare against averaged scores of synthetic drug-like compounds to determine if a particular protein would be a potential target of a compound of interest. Here we provide examples of natural products screened through our system as we assess advantages and shortcomings of our current system in regards to natural product drug discovery.

  20. Development and exploration of potential routes of discovery of new superconductors

    Energy Technology Data Exchange (ETDEWEB)

    Lin, Xiao [Iowa State Univ., Ames, IA (United States)

    2013-01-01

    This thesis summarizes our efforts to develop and explore potential routes for the discovery of new superconductors. The development of viable solutions for sulfur-bearing compounds is presented. It also provides the details of searching for quantum critical points (QCPs) and possible superconductors by suppressing ferromagnetic states via chemical substitution and the application of pressure. The ferromagnetism in La(VxCr1-x)Ge3 was successfully suppressed by pressure, and, in addition, a potential QCP at ambient pressure was discovered for x = 0.16. On the other hand, the La(VxCr1-x)Sb3 series is likely to evolve into new magnetic state with V-substitution with the Cr-based magnetism appearing to be more local-moment like than for the case of LaCrGe3. We also performed detailed characterization on BaSn5 superconductor, giving further understanding of its superconducting state, and on R3Ni2-xSn7 and RNi1-xBi2±y series putting to rest spurious claims of superconductivity.

  1. A semiparametric modeling framework for potential biomarker discovery and the development of metabonomic profiles

    Directory of Open Access Journals (Sweden)

    Dey Dipak K

    2008-01-01

    Full Text Available Abstract Background The discovery of biomarkers is an important step towards the development of criteria for early diagnosis of disease status. Recently electrospray ionization (ESI and matrix assisted laser desorption (MALDI time-of-flight (TOF mass spectrometry have been used to identify biomarkers both in proteomics and metabonomics studies. Data sets generated from such studies are generally very large in size and thus require the use of sophisticated statistical techniques to glean useful information. Most recent attempts to process these types of data model each compound's intensity either discretely by positional (mass to charge ratio clustering or through each compounds' own intensity distribution. Traditionally data processing steps such as noise removal, background elimination and m/z alignment, are generally carried out separately resulting in unsatisfactory propagation of signals in the final model. Results In the present study a novel semi-parametric approach has been developed to distinguish urinary metabolic profiles in a group of traumatic patients from those of a control group consisting of normal individuals. Data sets obtained from the replicates of a single subject were used to develop a functional profile through Dirichlet mixture of beta distribution. This functional profile is flexible enough to accommodate variability of the instrument and the inherent variability of each individual, thus simultaneously addressing different sources of systematic error. To address instrument variability, all data sets were analyzed in replicate, an important issue ignored by most studies in the past. Different model comparisons were performed to select the best model for each subject. The m/z values in the window of the irregular pattern are then further recommended for possible biomarker discovery. Conclusion To the best of our knowledge this is the very first attempt to model the physical process behind the time-of flight mass

  2. Improving the ATLAS physics potential with the Fast Track Trigger System

    CERN Document Server

    Cavaliere, Viviana; The ATLAS collaboration

    2015-01-01

    The ATLAS Fast TracKer (FTK) is a custom electronics system that will operate at the full Level-1 accept rate, 100 kHz, to provide high quality tracks as input to the High-Level Trigger. The event reconstruction is performed in hardware, thanks to the massive parallelism of associative memories (AM) and FPGAs. We present the advantages for the physics goals of the ATLAS experiment and the recent results on the design, technological advancements and testing of some of the core components used in the processor.

  3. ATLAS physics results

    CERN Document Server

    AUTHOR|(CDS)2074312

    2015-01-01

    The ATLAS experiment at the Large Hadron Collider at CERN has been successfully taking data since the end of 2009 in proton-proton collisions at centre-of-mass energies of 7 and 8 TeV, and in heavy ion collisions. In these lectures, some of the most recent ATLAS results will be given on Standard Model measurements, the discovery of the Higgs boson, searches for supersymmetry and exotics and on heavy-ion results.

  4. The ATLAS FTK system: how to improve the physics potential with a tracking trigger

    CERN Document Server

    Iizawa, T; The ATLAS collaboration

    2014-01-01

    After a very successful data taking run, the ATLAS experiment [1] is being upgraded to cope with the higher luminosity and higher center of mass energy that the Large Hadron Collider (LHC) will provide in the next years. The Fast Tracker (FTK) trigger system, part of the ATLAS trigger upgrade program, is a highly parallel hardware device processor based on a mixture of advanced technologies. Modern, powerful Field Programmable Gate Arrays (FPGAs) form an important part of the system architecture, and the large level of computing power required for pattern recognition is provided by incorporating standard-cell ASICs named Associative Memory (AM). FTK provides global track reconstruction in the full inner silicon detector, with resolution comparable to the offline algorithms, in approximately 100 microseconds, allowing a fast and precise detection of the primary and secondary vertex information. The track and vertex information is then used by the high-level trigger (HLT) algorithms, allowing highly improved tr...

  5. The ATLAS FTK system: how to improve the physics potential with a tracking trigger

    CERN Document Server

    Iizawa, T; The ATLAS collaboration

    2014-01-01

    After a very successful data taking run, the ATLAS experiment is being upgraded to cope with the higher luminosity and higher center of mass energy that the Large Hadron Collider will provide in the next years. The Fast Tracker (FTK) trigger system, part of the ATLAS trigger upgrade program, is a highly parallel hardware device designed to operate at the level-1 trigger output rate. FTK is a dedicated processor based on a mixture of advanced technologies. Modern, powerful Field Programmable Gate Arrays (FPGAs) form an important part of the system architecture, and the large level of computing power required for pattern recognition is provided by incorporating standard-cell ASICs named Associative Memories (AM). FTK provides global track reconstruction in the full inner silicon detector, with resolution comparable to the offline algorithms, in approximately 100 microseconds, allowing a fast and precise detection of the primary and secondary vertex information. The track and vertex information is then used by t...

  6. Potential of knowledge discovery using workflows implemented in the C3Grid

    Science.gov (United States)

    Engel, Thomas; Fink, Andreas; Ulbrich, Uwe; Schartner, Thomas; Dobler, Andreas; Fritzsch, Bernadette; Hiller, Wolfgang; Bräuer, Benny

    2013-04-01

    alteration of surface cyclones. A specific feature of C3Grid is the flexible Workflow Scheduling Service (WSS) which also allows for automated nightly analysis runs of CT, Stormtrack, etc. with different input parameter sets. The statistical results of these workflows can be accumulated afterwards by a scheduled final analysis step, thereby providing a tool for data intensive analytics for the massive amounts of climate model data accessible through C3Grid. First tests with these automated analysis workflows show promising results to speed up the investigation of high volume modeling data. This example is relevant to the thorough analysis of future changes in storminess in Europe and is just one example of the potential of knowledge discovery using automated workflows implemented in the C3Grid architecture.

  7. A scientometric prediction of the discovery of the first potentially habitable planet with a mass similar to Earth.

    Directory of Open Access Journals (Sweden)

    Samuel Arbesman

    Full Text Available BACKGROUND: The search for a habitable extrasolar planet has long interested scientists, but only recently have the tools become available to search for such planets. In the past decades, the number of known extrasolar planets has ballooned into the hundreds, and with it, the expectation that the discovery of the first Earth-like extrasolar planet is not far off. METHODOLOGY/PRINCIPAL FINDINGS: Here, we develop a novel metric of habitability for discovered planets and use this to arrive at a prediction for when the first habitable planet will be discovered. Using a bootstrap analysis of currently discovered exoplanets, we predict the discovery of the first Earth-like planet to be announced in the first half of 2011, with the likeliest date being early May 2011. CONCLUSIONS/SIGNIFICANCE: Our predictions, using only the properties of previously discovered exoplanets, accord well with external estimates for the discovery of the first potentially habitable extrasolar planet and highlight the the usefulness of predictive scientometric techniques to understand the pace of scientific discovery in many fields.

  8. Potential insight for drug discovery from high fidelity receptor-mediated transduction mechanisms in insects

    Science.gov (United States)

    Raffa, Robert B.; Raffa, Kenneth F.

    2011-01-01

    Introduction There is a pervasive and growing concern about the small number of new pharmaceutical agents. There are many proposed explanations for this trend that do not involve the drug-discovery process per se, but the discovery process itself has also come under scrutiny. If the current paradigms are indeed not working, where are novel ideas to come from? Perhaps it is time to look to novel sources. Areas covered The receptor-signaling and 2nd-messenger transduction processes present in insects are quite similar to those in mammals (involving G proteins, ion channels, etc.). However, a review of these systems reveals an unprecedented degree of high potency and receptor selectivity to an extent greater than that modeled in most current drug-discovery approaches. Expert opinion A better understanding of insect receptor pharmacology could stimulate novel theoretical and practical ideas in mammalian pharmacology (drug discovery) and, conversely, the application of pharmacology and medicinal chemistry principles could stimulate novel advances in entomology (safer and more targeted control of pest species). PMID:21984882

  9. The ATLAS Analysis Model

    CERN Multimedia

    Amir Farbin

    The ATLAS Analysis Model is a continually developing vision of how to reconcile physics analysis requirements with the ATLAS offline software and computing model constraints. In the past year this vision has influenced the evolution of the ATLAS Event Data Model, the Athena software framework, and physics analysis tools. These developments, along with the October Analysis Model Workshop and the planning for CSC analyses have led to a rapid refinement of the ATLAS Analysis Model in the past few months. This article introduces some of the relevant issues and presents the current vision of the future ATLAS Analysis Model. Event Data Model The ATLAS Event Data Model (EDM) consists of several levels of details, each targeted for a specific set of tasks. For example the Event Summary Data (ESD) stores calorimeter cells and tracking system hits thereby permitting many calibration and alignment tasks, but will be only accessible at particular computing sites with potentially large latency. In contrast, the Analysis...

  10. Open Innovation Drug Discovery (OIDD): a potential path to novel therapeutic chemical space.

    Science.gov (United States)

    Alvim-Gaston, Maria; Grese, Timothy; Mahoui, Abdelaziz; Palkowitz, Alan D; Pineiro-Nunez, Marta; Watson, Ian

    2014-01-01

    The continued development of computational and synthetic methods has enabled the enumeration or preparation of a nearly endless universe of chemical structures. Nevertheless, the ability of this chemical universe to deliver small molecules that can both modulate biological targets and have drug-like physicochemical properties continues to be a topic of interest to the pharmaceutical industry and academic researchers alike. The chemical space described by public, commercial, in-house and virtual compound collections has been interrogated by multiple approaches including biochemical, cellular and virtual screening, diversity analysis, and in-silico profiling. However, current drugs and known chemical probes derived from these efforts are contained within a remarkably small volume of the predicted chemical space. Access to more diverse classes of chemical scaffolds that maintain the properties relevant for drug discovery is certainly needed to meet the increasing demands for pharmaceutical innovation. The Lilly Open Innovation Drug Discovery platform (OIDD) was designed to tackle barriers to innovation through the identification of novel molecules active in relevant disease biology models. In this article we will discuss several computational approaches towards describing novel, biologically active, drug-like chemical space and illustrate how the OIDD program may facilitate access to previously untapped molecules that may aid in the search for innovative pharmaceuticals.

  11. Open Innovation Drug Discovery (OIDD): a potential path to novel therapeutic chemical space.

    Science.gov (United States)

    Alvim-Gaston, Maria; Grese, Timothy; Mahoui, Abdelaziz; Palkowitz, Alan D; Pineiro-Nunez, Marta; Watson, Ian

    2014-01-01

    The continued development of computational and synthetic methods has enabled the enumeration or preparation of a nearly endless universe of chemical structures. Nevertheless, the ability of this chemical universe to deliver small molecules that can both modulate biological targets and have drug-like physicochemical properties continues to be a topic of interest to the pharmaceutical industry and academic researchers alike. The chemical space described by public, commercial, in-house and virtual compound collections has been interrogated by multiple approaches including biochemical, cellular and virtual screening, diversity analysis, and in-silico profiling. However, current drugs and known chemical probes derived from these efforts are contained within a remarkably small volume of the predicted chemical space. Access to more diverse classes of chemical scaffolds that maintain the properties relevant for drug discovery is certainly needed to meet the increasing demands for pharmaceutical innovation. The Lilly Open Innovation Drug Discovery platform (OIDD) was designed to tackle barriers to innovation through the identification of novel molecules active in relevant disease biology models. In this article we will discuss several computational approaches towards describing novel, biologically active, drug-like chemical space and illustrate how the OIDD program may facilitate access to previously untapped molecules that may aid in the search for innovative pharmaceuticals. PMID:24283973

  12. Potential performance characteristics of ICESat-2/ATLAS for canopy height retrievals in different ecosystems

    Science.gov (United States)

    Neuenschwander, A. L.; Pitts, K.

    2015-12-01

    With an expected launch in late 2017 (or early 2018), the ICESat-2 satellite will provide a global distribution of geodetic measurements of both the terrain surface and relative canopy heights which will provide a significant benefit to society through a variety of applications including forest structural mapping and improved global digital terrain models. The Advanced Topographic Laser Altimeter System (ATLAS) instrument on ICESat-2 will utilize a photon counting lidar which utilizes low power laser pulse with detectors sensitive at the single photon level. Due to this type of detector, any returned photon whether from the reflected signal or solar background can trigger a detection event. The ATLAS instrument will record the arrival time associated with a single photon detection that can occur anywhere within the vertical distribution of the reflected signal, that is, anywhere within the vertical distribution of the canopy. One of the uncertainties facing the ecosystem community is a comprehensive understanding of the performance of ICESat-2 will be for various ecosystems. Specifically, which ecosystems -and to a greater extent- what amount of canopy cover will create constraints on the ability to derive relative canopy height from ICESat-2 measurements. This paper aims to provide the science and user community of the ICESat-2 land/vegetation data products with a realistic understanding of the performance characteristics and subsequent data quality and the associated errors. To simulate ICESat-2/ATLAS data, data from small-footprint waveform lidar are the best surrogate for empirically deriving simulated ICESat-2 data as the entire temporal profile of the laser energy is recorded on each waveform. As such, a normalized waveform is the probability of where a photon is returned from the reflecting surface along the laser line-of-sight. Using this empirical approach, simulated ICESat-2 data can be developed for a variety of ecosystems ranging from sparse shrublands

  13. Preparation of the ATLAS experiment in the LHC proton collider, performances of the electromagnetic calorimeter and its potentialities for the top quark

    International Nuclear Information System (INIS)

    ATLAS is the biggest and the more complex detector ever built, it will operate on the LHC and is the outcome of a huge international collaboration of 2000 physicists. This document reviews the theoretical and experimental achievements of one of them, his collaboration spread over 7 years and has followed 2 axis. First, the design, construction and test of the electromagnetic calorimeter of ATLAS and secondly, the development of analysis strategies in the physics of the top quark. The expected important production of top quarks in LHC will allow an accurate measurement of the properties of this particle and in the same way will provide new testing areas for the standard model. The top quark, being extremely massive, might play a significant role in the mechanism of electro-weak symmetry breaking. This document is organized into 5 chapters: 1) ATLAS detector, performance and progress, 2) the optimization of the energy measurement with the electromagnetic calorimeter, 3) the performance of the electromagnetic calorimeter, 4) the physics of the top quark, and 5) the potentialities of ATLAS in the top quark sector. This document presented before an academic board will allow its author to manage research works and particularly to tutor thesis students. (A.C.)

  14. Small Molecules from Nature Targeting G-Protein Coupled Cannabinoid Receptors: Potential Leads for Drug Discovery and Development

    Directory of Open Access Journals (Sweden)

    Charu Sharma

    2015-01-01

    Full Text Available The cannabinoid molecules are derived from Cannabis sativa plant which acts on the cannabinoid receptors types 1 and 2 (CB1 and CB2 which have been explored as potential therapeutic targets for drug discovery and development. Currently, there are numerous cannabinoid based synthetic drugs used in clinical practice like the popular ones such as nabilone, dronabinol, and Δ9-tetrahydrocannabinol mediates its action through CB1/CB2 receptors. However, these synthetic based Cannabis derived compounds are known to exert adverse psychiatric effect and have also been exploited for drug abuse. This encourages us to find out an alternative and safe drug with the least psychiatric adverse effects. In recent years, many phytocannabinoids have been isolated from plants other than Cannabis. Several studies have shown that these phytocannabinoids show affinity, potency, selectivity, and efficacy towards cannabinoid receptors and inhibit endocannabinoid metabolizing enzymes, thus reducing hyperactivity of endocannabinoid systems. Also, these naturally derived molecules possess the least adverse effects opposed to the synthetically derived cannabinoids. Therefore, the plant based cannabinoid molecules proved to be promising and emerging therapeutic alternative. The present review provides an overview of therapeutic potential of ligands and plants modulating cannabinoid receptors that may be of interest to pharmaceutical industry in search of new and safer drug discovery and development for future therapeutics.

  15. Therapeutic Potential of Plants as Anti-Microbials for Drug Discovery

    Directory of Open Access Journals (Sweden)

    Ramar Perumal Samy

    2010-01-01

    Full Text Available The uses of traditional medicinal plants for primary health care have steadily increased worldwide in recent years. Scientists are in search of new phytochemicals that could be developed as useful anti-microbials for treatment of infectious diseases. Currently, out of 80% of pharmaceuticals derived from plants, very few are now being used as anti-microbials. Plants are rich in a wide variety of secondary metabolites that have found anti-microbial properties. This review highlights the current status of traditional medicine, its contribution to modern medicine, recent trends in the evaluation of anti-microbials with a special emphasis upon some tribal medicine, in vitro and in vivo experimental design for screening, and therapeutic efficacy in safety and human clinical trails for commercial outlet. Many of these commercially available compounds are crude preparations administered without performing human clinical trials. Recent methods are useful to standardize the extraction for scientific investigation of new phytochemicals and anti-microbials of traditionally used plants. It is concluded that once the local ethnomedical preparations of traditional sources are scientifically evaluated before dispensing they should replace existing drugs commonly used for the therapeutic treatment of infection. This method should be put into practice for future investigations in the field of ethnopharmacology, phytochemistry, ethnobotany and other biological fields for drug discovery.

  16. The discovery of antidepressant drugs by computer-analyzed human cerebral bio-electrical potentials (CEEG).

    Science.gov (United States)

    Itil, T M

    1983-01-01

    Antidepressant properties of six compounds were predicted based on their computer-analyzed human electroencephalographical (CEEG) profiles. The clinical investigations with mianserin (GB-94) confirmed the CEEG prediction. This compound has now been marketed as the first antidepressant of which the clinical effects were discovered solely by the quantitative pharmaco-EEG method. As predicted by the CEEG, clinical antidepressant properties of GC-46, mesterolone, and estradiol valerate were observed in preliminary investigations. No extensive studies with definite statistical results were yet carried out with these compounds. No systematic large studies could be conducted with cyclozocine and cyproterone acetate because of the intolerable side effects with these compounds. The optical isomers of mianserin, GF-59 and GF-60, both predicted as antidepressant by the computer EEG data base, have not yet been tested in depressive patients. None of these compounds possess the "typical" pharmacological and/or biochemical profiles of marketed antidepressants. Thus, the discovery of the established antidepressant properties of mianserin (GB-94) by computer analyzed EEG method challenges the well-known biochemical hypotheses of depression and the "classical" development of antidepressant drugs. PMID:6142498

  17. Potential of Glutamate-Based Drug Discovery for Next Generation Antidepressants

    Directory of Open Access Journals (Sweden)

    Shigeyuki Chaki

    2015-09-01

    Full Text Available Recently, ketamine has been demonstrated to exert rapid-acting antidepressant effects in patients with depression, including those with treatment-resistant depression, and this discovery has been regarded as the most significant advance in drug development for the treatment of depression in over 50 years. To overcome unwanted side effects of ketamine, numerous approaches targeting glutamatergic systems have been vigorously investigated. For example, among agents targeting the NMDA receptor, the efficacies of selective GluN2B receptor antagonists and a low-trapping antagonist, as well as glycine site modulators such as GLYX-13 and sarcosine have been demonstrated clinically. Moreover, agents acting on metabotropic glutamate receptors, such as mGlu2/3 and mGlu5 receptors, have been proposed as useful approaches to mimicking the antidepressant effects of ketamine. Neural and synaptic mechanisms mediated through the antidepressant effects of ketamine have been being delineated, most of which indicate that ketamine improves abnormalities in synaptic transmission and connectivity observed in depressive states via the AMPA receptor and brain-derived neurotrophic factor-dependent mechanisms. Interestingly, some of the above agents may share some neural and synaptic mechanisms with ketamine. These studies should provide important insights for the development of superior pharmacotherapies for depression with more potent and faster onsets of actions.

  18. The discovery of antidepressant drugs by computer-analyzed human cerebral bio-electrical potentials (CEEG).

    Science.gov (United States)

    Itil, T M

    1983-01-01

    Antidepressant properties of six compounds were predicted based on their computer-analyzed human electroencephalographical (CEEG) profiles. The clinical investigations with mianserin (GB-94) confirmed the CEEG prediction. This compound has now been marketed as the first antidepressant of which the clinical effects were discovered solely by the quantitative pharmaco-EEG method. As predicted by the CEEG, clinical antidepressant properties of GC-46, mesterolone, and estradiol valerate were observed in preliminary investigations. No extensive studies with definite statistical results were yet carried out with these compounds. No systematic large studies could be conducted with cyclozocine and cyproterone acetate because of the intolerable side effects with these compounds. The optical isomers of mianserin, GF-59 and GF-60, both predicted as antidepressant by the computer EEG data base, have not yet been tested in depressive patients. None of these compounds possess the "typical" pharmacological and/or biochemical profiles of marketed antidepressants. Thus, the discovery of the established antidepressant properties of mianserin (GB-94) by computer analyzed EEG method challenges the well-known biochemical hypotheses of depression and the "classical" development of antidepressant drugs.

  19. Mesua beccariana (Clusiaceae, A Source of Potential Anti-cancer Lead Compounds in Drug Discovery

    Directory of Open Access Journals (Sweden)

    Soek Sin Teh

    2012-09-01

    Full Text Available An investigation on biologically active secondary metabolites from the stem bark of Mesua beccariana was carried out. A new cyclodione, mesuadione (1, along with several known constituents which are beccamarin (2, 2,5-dihydroxy-1,3,4-trimethoxy anthraquinone (3, 4-methoxy-1,3,5-trihydroxyanthraquinone (4, betulinic acid (5 and stigmasterol (6 were obtained from this ongoing research. Structures of these compounds were elucidated by extensive spectroscopic methods, including 1D and 2D-NMR, GC-MS, IR and UV techniques. Preliminary tests of the in vitro cytotoxic activities of all the isolated metabolites against a panel of human cancer cell lines Raji (lymphoma, SNU-1 (gastric carcinoma, K562 (erythroleukemia cells, LS-174T (colorectal adenocarcinoma, HeLa (cervical cells, SK-MEL-28 (malignant melanoma cells, NCI-H23 (lung adenocarcinoma, IMR-32 (neuroblastoma and Hep-G2 (hepatocellular liver carcinoma were carried out using an MTT assay. Mesuadione (1, beccamarin (2, betulinic acid (5 and stigmasterol (6 displayed strong inhibition of Raji cell proliferation, while the proliferation rate of SK-MEL-28 and HeLa were strongly inhibited by stigmasterol (6 and beccamarin (2, indicating these secondary metabolites could be anti-cancer lead compounds in drug discovery.

  20. ATLAS Virtual Visits

    CERN Document Server

    Goldfarb, Steven; The ATLAS collaboration

    2015-01-01

    ATLAS Virtual Visits is a project initiated in 2011 for the Education & Outreach program of the ATLAS Experiment at CERN. Its goal is to promote public appreciation of the LHC physics program and particle physics, in general, through direct dialogue between ATLAS physicists and remote audiences. A Virtual Visit is an IP-based videoconference, coupled with a public webcast and video recording, between ATLAS physicists and remote locations around the world, that typically include high school or university classrooms, Masterclasses, science fairs, or other special events, usually hosted by collaboration members. Over the past two years, more than 10,000 people, from all of the world’s continents, have actively participated in ATLAS Virtual Visits, with many more enjoying the experience from the publicly available webcasts and recordings. We present an overview of our experience and discuss potential development for the future.

  1. Wind Atlas for Egypt

    DEFF Research Database (Denmark)

    Mortensen, Niels Gylling; Said Said, Usama; Badger, Jake

    2006-01-01

    The results of a comprehensive, 8-year wind resource assessment programme in Egypt are presented. The objective has been to provide reliable and accurate wind atlas data sets for evaluating the potential wind power output from large electricityproducing wind turbine installations. The regional wind...... climates of Egypt have been determined by two independent methods: a traditional wind atlas based on observations from more than 30 stations all over Egypt, and a numerical wind atlas based on long-term reanalysis data and a mesoscale model (KAMM). The mean absolute error comparing the two methods is about...... 10% for two large-scale KAMM domains covering all of Egypt, and typically about 5% for several smaller-scale regional domains. The numerical wind atlas covers all of Egypt, whereas the meteorological stations are concentrated in six regions. The Wind Atlas for Egypt represents a significant step...

  2. Wind Atlas for Egypt

    DEFF Research Database (Denmark)

    The results of a comprehensive, 8-year wind resource assessment programme in Egypt are presented. The objective has been to provide reliable and accurate wind atlas data sets for evaluating the potential wind power output from large electricityproducing wind turbine installations. The regional wind...... climates of Egypt have been determined by two independent methods: a traditional wind atlas based on observations from more than 30 stations all over Egypt, and a numerical wind atlas based on long-term reanalysis data and a mesoscale model (KAMM). The mean absolute error comparing the two methods is about...... 10% for two large-scale KAMM domains covering all of Egypt, and typically about 5% for several smaller-scale regional domains. The numerical wind atlas covers all of Egypt, whereas the meteorological stations are concentrated in six regions. The Wind Atlas for Egypt represents a significant step...

  3. Search for high mass resonances in the dimuon channel using the muon spectrometer of the atlas experiment at CERN

    International Nuclear Information System (INIS)

    This thesis covers the search of new neutral gauge bosons decaying into a pair of muons in the ATLAS detector. The Large Hadron Collider (LHC) at CERN will produce parton collisions with very high center of mass energy and may produce Z' predicted by many theories beyond the standard model. Such a resonance should be detected by the ATLAS experiment. For the direct search of Z' decaying into two muons, a small number of events is enough for its discovery, which is possible with the first data. We shall study in particular the effects of the muon spectrometer alignment on high pT tracks and on the Z' discovery potential in the ATLAS experiment. The discovery potentials computed with this method have been officially approved by the ATLAS collaboration and published. At the start of the LHC operation, the muon spectrometer alignment will not have reached the nominal performances. This analysis aims at optimizing the discovery potential of ATLAS for a Z' boson in this degraded initial conditions. The impact on track reconstruction of a degraded alignment is estimated with simulated high pT tracks. Results are given in terms of reconstruction efficiency, momentum and invariant mass resolutions, charge identification and sensitivity to discovery or exclusion. With the first data, an analysis using only the muon spectrometer in stand alone mode will be very useful. Finally, a study on how to determine the initial geometry of the spectrometer (needed for its absolute alignment) is performed. This study uses straight tracks without a magnetic field and also calculates the beam time necessary for reaching a given accuracy of the alignment system. (author)

  4. The potential use of SUISEKI as a protein interaction discovery tool.

    Science.gov (United States)

    Blaschke, C; Valencia, A

    2001-01-01

    Relevant information about protein interactions is stored in textual sources. This sources are commonly used not only as archives of what is already known but also as information for generating new knowledge, particularly to pose hypothesis about new possible interactions that can be inferred from the existing ones. This task is the more creative part of scientific work in experimental systems. We present a large-scale analysis for the prediction of new interactions based on the interaction network for the ones already known and detected automatically in the literature. During the last few years it has became clear that part of the information about protein interactions could be extracted with automatic tools, even if these tools are still far from perfect and key problems such as detection of protein names are not completely solved. We have developed a integrated automatic approach, called SUISEKI (System for Information Extraction on Interactions), able to extract protein interactions from collections of Medline abstracts. Previous experiments with the system have shown that it is able to extract almost 70% of the interactions present in relatively large text corpus, with an accuracy of approximately 80% (for the best defined interactions) that makes the system usable in real scenarios, both at the level of extraction of protein names and at the level of extracting interaction between them. With the analysis of the interaction map of Saccharomyces cerevisiae we show that interactions published in the years 2000/2001 frequently correspond to proteins or genes that were already very close in the interaction network deduced from the literature published before these years and that they are often connected to the same proteins. That is, discoveries are commonly done among highly connected entities. Some biologically relevant examples illustrate how interactions described in the year 2000 could have been proposed as reasonable working hypothesis with the information

  5. ATLAS Recordings

    CERN Multimedia

    Steven Goldfarb; Mitch McLachlan; Homer A. Neal

    Web Archives of ATLAS Plenary Sessions, Workshops, Meetings, and Tutorials from 2005 until this past month are available via the University of Michigan portal here. Most recent additions include the Trigger-Aware Analysis Tutorial by Monika Wielers on March 23 and the ROOT Workshop held at CERN on March 26-27.Viewing requires a standard web browser with RealPlayer plug-in (included in most browsers automatically) and works on any major platform. Lectures can be viewed directly over the web or downloaded locally.In addition, you will find access to a variety of general tutorials and events via the portal.Feedback WelcomeOur group is making arrangements now to record plenary sessions, tutorials, and other important ATLAS events for 2007. Your suggestions for potential recording, as well as your feedback on existing archives is always welcome. Please contact us at wlap@umich.edu. Thank you.Enjoy the Lectures!

  6. The discovery of potential acetylcholinesterase inhibitors: A combination of pharmacophore modeling, virtual screening, and molecular docking studies

    Directory of Open Access Journals (Sweden)

    Chuang Chih-Kuang

    2011-01-01

    Full Text Available Abstract Background Alzheimer's disease (AD is the most common cause of dementia characterized by progressive cognitive impairment in the elderly people. The most dramatic abnormalities are those of the cholinergic system. Acetylcholinesterase (AChE plays a key role in the regulation of the cholinergic system, and hence, inhibition of AChE has emerged as one of the most promising strategies for the treatment of AD. Methods In this study, we suggest a workflow for the identification and prioritization of potential compounds targeted against AChE. In order to elucidate the essential structural features for AChE, three-dimensional pharmacophore models were constructed using Discovery Studio 2.5.5 (DS 2.5.5 program based on a set of known AChE inhibitors. Results The best five-features pharmacophore model, which includes one hydrogen bond donor and four hydrophobic features, was generated from a training set of 62 compounds that yielded a correlation coefficient of R = 0.851 and a high prediction of fit values for a set of 26 test molecules with a correlation of R2 = 0.830. Our pharmacophore model also has a high Güner-Henry score and enrichment factor. Virtual screening performed on the NCI database obtained new inhibitors which have the potential to inhibit AChE and to protect neurons from Aβ toxicity. The hit compounds were subsequently subjected to molecular docking and evaluated by consensus scoring function, which resulted in 9 compounds with high pharmacophore fit values and predicted biological activity scores. These compounds showed interactions with important residues at the active site. Conclusions The information gained from this study may assist in the discovery of potential AChE inhibitors that are highly selective for its dual binding sites.

  7. The battle of Alzheimer disease - the beginning of the futureUnleashing the potential of academic discoveries

    Directory of Open Access Journals (Sweden)

    Johan eLundkvist

    2014-05-01

    Full Text Available Alzheimer Disease (AD is the most common form of dementia, affecting approximately 36 million people worldwide. To date there is no preventive or curative treatment available for AD, and in absence of major progress in therapeutic development, AD manifests a concrete socioeconomic threat. The awareness of the growing problem of AD is increasing, exemplified by the recent G8 Dementia Summit, a meeting held in order to set the stage and steer the compass for the future. Simultaneously, and paradoxically, we have seen key players in the pharmaceutical industry that have recently closed or significantly decreased their R&D spending on AD and other CNS disorders. Given the pressing need for new treatments in this area, other actors need to step-in and enter this drug discovery arena complementing the industrial efforts, in order to turn biological and technological progress into novel therapeutics. In this article, we present an example of a novel drug discovery initiative that in a non-profit setting, aims to integrate with both preclinical and clinical academic groups and pharmaceutical industry to explore the therapeutic potential of new concepts in patients, using novel biology, state of the art technologies and rapid concept

  8. In Silico discovery of transcription factors as potential diagnostic biomarkers of ovarian cancer

    Directory of Open Access Journals (Sweden)

    Choolani Mahesh

    2011-09-01

    Full Text Available Abstract Background Our study focuses on identifying potential biomarkers for diagnosis and early detection of ovarian cancer (OC through the study of transcription regulation of genes affected by estrogen hormone. Results The results are based on a set of 323 experimentally validated OC-associated genes compiled from several databases, and their subset controlled by estrogen. For these two gene sets we computationally determined transcription factors (TFs that putatively regulate transcription initiation. We ranked these TFs based on the number of genes they are likely to control. In this way, we selected 17 top-ranked TFs as potential key regulators and thus possible biomarkers for a set of 323 OC-associated genes. For 77 estrogen controlled genes from this set we identified three unique TFs as potential biomarkers. Conclusions We introduced a new methodology to identify potential diagnostic biomarkers for OC. This report is the first bioinformatics study that explores multiple transcriptional regulators of OC-associated genes as potential diagnostic biomarkers in connection with estrogen responsiveness. We show that 64% of TF biomarkers identified in our study are validated based on real-time data from microarray expression studies. As an illustration, our method could identify CP2 that in combination with CA125 has been reported to be sensitive in diagnosing ovarian tumors.

  9. In Silico discovery of transcription factors as potential diagnostic biomarkers of ovarian cancer

    KAUST Repository

    Kaur, Mandeep

    2011-09-19

    Background: Our study focuses on identifying potential biomarkers for diagnosis and early detection of ovarian cancer (OC) through the study of transcription regulation of genes affected by estrogen hormone.Results: The results are based on a set of 323 experimentally validated OC-associated genes compiled from several databases, and their subset controlled by estrogen. For these two gene sets we computationally determined transcription factors (TFs) that putatively regulate transcription initiation. We ranked these TFs based on the number of genes they are likely to control. In this way, we selected 17 top-ranked TFs as potential key regulators and thus possible biomarkers for a set of 323 OC-associated genes. For 77 estrogen controlled genes from this set we identified three unique TFs as potential biomarkers.Conclusions: We introduced a new methodology to identify potential diagnostic biomarkers for OC. This report is the first bioinformatics study that explores multiple transcriptional regulators of OC-associated genes as potential diagnostic biomarkers in connection with estrogen responsiveness. We show that 64% of TF biomarkers identified in our study are validated based on real-time data from microarray expression studies. As an illustration, our method could identify CP2 that in combination with CA125 has been reported to be sensitive in diagnosing ovarian tumors. 2011 Kaur et al; licensee BioMed Central Ltd.

  10. Prospects for Higgs Searches via VBF at the LHC with the ATLAS Detector

    CERN Document Server

    Cranmer, K; Mellado, B; Paganis, S; Quayle, W; Wu Sau Lan; Wu, Sau Lan

    2004-01-01

    We report on the potential for the discovery of a Standard Model Higgs boson with the vector boson fusion mechanism in the mass range $115ATLAS experiment at the LHC. Feasibility studies at hadron level followed by a fast detector simulation have been performed for $H\\rightarrow W^{(*)}W^{(*)}\\rightarrow l^+l^-\\sla{p_T}$, $H\\rightarrow\\gamma\\gamma$ and $H\\rightarrow ZZ\\rightarrow l^+l^-q\\overline{q}$. The results obtained show a large discovery potential in the range $115

  11. Discovery of wall teichoic acid inhibitors as potential anti-MRSA β-lactam combination agents.

    Science.gov (United States)

    Wang, Hao; Gill, Charles J; Lee, Sang H; Mann, Paul; Zuck, Paul; Meredith, Timothy C; Murgolo, Nicholas; She, Xinwei; Kales, Susan; Liang, Lianzhu; Liu, Jenny; Wu, Jin; Santa Maria, John; Su, Jing; Pan, Jianping; Hailey, Judy; Mcguinness, Debra; Tan, Christopher M; Flattery, Amy; Walker, Suzanne; Black, Todd; Roemer, Terry

    2013-02-21

    Innovative strategies are needed to combat drug resistance associated with methicillin-resistant Staphylococcus aureus (MRSA). Here, we investigate the potential of wall teichoic acid (WTA) biosynthesis inhibitors as combination agents to restore β-lactam efficacy against MRSA. Performing a whole-cell pathway-based screen, we identified a series of WTA inhibitors (WTAIs) targeting the WTA transporter protein, TarG. Whole-genome sequencing of WTAI-resistant isolates across two methicillin-resistant Staphylococci spp. revealed TarG as their common target, as well as a broad assortment of drug-resistant bypass mutants mapping to earlier steps of WTA biosynthesis. Extensive in vitro microbiological analysis and animal infection studies provide strong genetic and pharmacological evidence of the potential effectiveness of WTAIs as anti-MRSA β-lactam combination agents. This work also highlights the emerging role of whole-genome sequencing in antibiotic mode-of-action and resistance studies.

  12. Selective androgen receptor modulators in drug discovery: medicinal chemistry and therapeutic potential.

    Science.gov (United States)

    Cadilla, Rodolfo; Turnbull, Philip

    2006-01-01

    Modulation of the androgen receptor has the potential to be an effective treatment for hypogonadism, andropause, and associated conditions such as sarcopenia, osteoporosis, benign prostatic hyperplasia, and sexual dysfunction. Side effects associated with classical anabolic steroid treatments have driven the quest for drugs that demonstrate improved therapeutic profiles. Novel, non-steroidal compounds that show tissue selective activity and improved pharmacokinetic properties have been developed. This review provides an overview of current advances in the development of selective androgen receptor modulators (SARMs).

  13. Discovery of Acupoints and Combinations with Potential to Treat Vascular Dementia: A Data Mining Analysis

    Directory of Open Access Journals (Sweden)

    Shuwei Feng

    2015-01-01

    Full Text Available The prevalence of vascular dementia (VaD is high among the elderly. Acupuncture, a popular therapeutic method in China, can improve memory, orientation, calculation, and self-managing ability in VaD patients. However, in clinical acupuncture and acupuncture research, the selection of acupoints to treat VaD remains challenging. This study aimed to discover acupoints and acupoint combinations with potential for VaD based on data mining. After database searching and screening for articles on clinical trials evaluating the effects of acupuncture on VaD, 238 acupuncture prescriptions were included for further analysis. Baihui (GV 20, Sishencong (EX-HN 1, Fengchi (GB 20, Shuigou (GV 26, and Shenting (GV 24 appeared most frequently in the modern literature and are potential acupoints for VaD. Combinations between Baihui (GV 20, Sishencong (EX-HN 1, Fengchi (GB 20, Shenting (GV 24, Shuigou (GV 26, and Zusanli (ST 36 were most frequent and represent potential combinations for VaD treatment. These results provide a reference for the selection and combination of acupoints to treat VaD in clinical acupuncture and acupuncture research.

  14. Pharmacophore development and screening for discovery of potential inhibitors of ADAMTS-4 for osteoarthritis therapy.

    Science.gov (United States)

    Verma, Priyanka; Dalal, Krishna; Chopra, Madhu

    2016-08-01

    In the development of osteoarthritis, aggrecan degrades prior to cartilage destruction. Aggrecanase-1 (ADAMTS-4) is considered to be the major enzyme responsible for cleaving the Glu373-Ala374 bond in the interglobular domain of aggrecan in humans. Therefore, inhibitors of ADAMTS-4 have therapeutic potential in the treatment of osteoarthritis. In the present work, we developed a chemical feature based pharmacophore model of ADAMTS-4 inhibitors using the HipHop module within the Catalyst program package in order to elucidate the structure-activity relationship and to carry out in-silico screening. The Maybridge database was screened using Hypo1 as a 3D query, and the best-fit hits that followed Lipinski's rule of five were subsequently screened to select the compounds. The hit compounds were then docked into the active site of ADAMTS-4, and interactions were visualized to determine the potential lead molecules. After subjecting all of the hits to various screening and filtering processes, 13 compounds were finally evaluated for their in vitro inhibitory activities. This study resulted in the identification of two lead compounds with potent inhibitory effects on ADAMTS-4 activity, with IC50 values of 0.042 μM and 0.028 μM, respectively. These results provide insight into the pharmacophoric requirements for the development of more potent ADAMTS-4 inhibitors. Graphical Abstract The aggrecan-degrading metalloprotease ADAMTS-4 has been identified as a novel therapeutic target for osteoarthritis. In this work, we used HipHop-based pharmacophore modeling and virtual screening of the Maybridge database to identify novel ADAMTS-4 inhibitors. These novel lead compounds act as potent and specific inhibitors for the ADAMTS-4 enzyme and could have therapeutic potential in the treatment of OA. PMID:27401455

  15. Pharmacophore development and screening for discovery of potential inhibitors of ADAMTS-4 for osteoarthritis therapy.

    Science.gov (United States)

    Verma, Priyanka; Dalal, Krishna; Chopra, Madhu

    2016-08-01

    In the development of osteoarthritis, aggrecan degrades prior to cartilage destruction. Aggrecanase-1 (ADAMTS-4) is considered to be the major enzyme responsible for cleaving the Glu373-Ala374 bond in the interglobular domain of aggrecan in humans. Therefore, inhibitors of ADAMTS-4 have therapeutic potential in the treatment of osteoarthritis. In the present work, we developed a chemical feature based pharmacophore model of ADAMTS-4 inhibitors using the HipHop module within the Catalyst program package in order to elucidate the structure-activity relationship and to carry out in-silico screening. The Maybridge database was screened using Hypo1 as a 3D query, and the best-fit hits that followed Lipinski's rule of five were subsequently screened to select the compounds. The hit compounds were then docked into the active site of ADAMTS-4, and interactions were visualized to determine the potential lead molecules. After subjecting all of the hits to various screening and filtering processes, 13 compounds were finally evaluated for their in vitro inhibitory activities. This study resulted in the identification of two lead compounds with potent inhibitory effects on ADAMTS-4 activity, with IC50 values of 0.042 μM and 0.028 μM, respectively. These results provide insight into the pharmacophoric requirements for the development of more potent ADAMTS-4 inhibitors. Graphical Abstract The aggrecan-degrading metalloprotease ADAMTS-4 has been identified as a novel therapeutic target for osteoarthritis. In this work, we used HipHop-based pharmacophore modeling and virtual screening of the Maybridge database to identify novel ADAMTS-4 inhibitors. These novel lead compounds act as potent and specific inhibitors for the ADAMTS-4 enzyme and could have therapeutic potential in the treatment of OA.

  16. Cure from the cave: volcanic cave actinomycetes and their potential in drug discovery

    Directory of Open Access Journals (Sweden)

    Cheeptham N.

    2013-01-01

    Full Text Available Volcanic caves have been little studied for their potential as sources of novel microbial species and bioactive compounds with new scaffolds. We present the f irst study of volcanic cave microbiology from Canada and suggest that this habitat has great potential for the isolation of novel bioactive substances. Sample locat ions were plot ted on a contour map that was compiled in ArcView 3.2. Over 400 bacterial isolates were obtained from the Helmcken Falls cave in Wells Gray Provincial Park, British Columbia. From our preliminary screen, of 400 isolates tested, 1% showed activity against extended spectrum ß-lactamase E. coli, 1.75% against Escherichia coli, 2.25% against Acinetobacter baumannii, and 26.50% against Klebsiella pneumoniae. In addition, 10.25% showed activity against Micrococcus luteus, 2% against methicillin resistant Staphylococcus aureus, 9.25% against Mycobacterium smegmatis, 6.25% Pseudomonas aeruginosa and 7.5% against Candida albicans. Chemical and physical characteristics of three rock wall samples were studied using scanning electron microscopy and f lame atomic absorption spectrometry. Calcium (Ca, iron (Fe, and aluminum (Al were the most abundant components while magnesium (Mg, sodium (Na, arsenic (As, lead (Pb, chromium (Cr, and barium (Ba were second most abundant with cadmium (Cd and potassium (K were the least abundant in our samples. Scanning electron microscopy (SEM showed the presence of microscopic life forms in all three rock wall samples. 16S rRNA gene sequencing of 82 isolates revealed that 65 (79.3% of the strains belong to the Streptomyces genus and 5 (6.1% were members of Bacillus, Pseudomonas, Nocardia and Erwinia genera. Interestingly, twelve (14.6% of the 16S rRNA sequences showed similarity to unidentif ied ribosomal RNA sequences in the library databases, the sequences of these isolates need to be further investigated using the EzTaxon-e database (http://eztaxon-e. ezbiocloud.net/ to determine whether

  17. Discovery potential for supernova relic neutrinos with slow liquid scintillator detectors

    CERN Document Server

    Wei, Hanyu; Chen, Shaomin

    2016-01-01

    The detection of supernova relic neutrinos would provide a key support for our current understanding of stellar and cosmological evolution, and precise measurements of them would further give us an insight of the profound universe. In this paper we study the potential to detect supernova relic neutrinos using linear alkyl benzene, LAB, as a slow liquid scintillator, which features a good separation of Cherenkov and scintillation lights, thus providing a new ability in particle identification. We also address key issues of current experiments, including 1) the charged current background of atmospheric neutrinos in water Cherenkov detectors, and 2) the neutral current background of atmospheric neutrinos in typical liquid scintillator detectors. With LAB, a kiloton-scale detector, like the SNO, KamLAND, and the future Jinping neutrino detectors, with $\\mathcal{O}$(10) years of data, would have the sensitivity to discover supernova relic neutrinos, which is comparable to large-volume water Cherenkov, typical liqu...

  18. Discovery of dihydrochalcone as potential lead for Alzheimer's disease: in silico and in vitro study.

    Directory of Open Access Journals (Sweden)

    Man Hoang Viet

    Full Text Available By the virtual screening method we have screened out Dihydrochalcone as a top-lead for the Alzheimer's disease using the database of about 32364 natural compounds. The binding affinity of this ligand to amyloid beta (Aβ fibril has been thoroughly studied by computer simulation and experiment. Using the Thioflavin T (ThT assay we have obtained the inhibition constant IC50 μM. This result is in good agreement with the estimation of the binding free energy obtained by the molecular mechanic-Poisson Boltzmann surface area method and all-atom simulation with the force field CHARMM 27 and water model TIP3P. Cell viability assays indicated that Dihydrochalcone could effectively reduce the cytotoxicity induced by Aβ. Thus, both in silico and in vitro studies show that Dihydrochalcone is a potential drug for the Alzheimers disease.

  19. Sumoylation in gene regulation and cardiac disease: potential for drug discovery

    Directory of Open Access Journals (Sweden)

    Beketaev I

    2014-11-01

    Full Text Available Ilimbek Beketaev, Jun Wang Center for Stem Cell Engineering, Department of Basic Research Laboratories, Texas Heart Institute at St Luke’s Episcopal Hospital, Houston, TX, USA Abstract: Small ubiquitin-related modifier (SUMO proteins are members of ubiquitin-like super-family proteins that can be covalently conjugated to their targets through multistep enzymatic reactions. Sumoylation has caught much attention due to its versatility, wide involvement in cellular events, and disease association. Sumoylation has been well studied at cellular and molecular levels. A newly emerging role that SUMO conjugation plays is in cardiac pathophysiology. In this review we will update new advances in the study of implications of the sumoylation pathway in the pathogenesis of cardiac diseases, discuss promise of the SUMO pathway as a potential therapeutic target, and conclude with future directions for SUMO research in the heart field. Keywords: posttranslational modification, SUMO, SENP, heart

  20. Multiple brain atlas database and atlas-based neuroimaging system.

    Science.gov (United States)

    Nowinski, W L; Fang, A; Nguyen, B T; Raphel, J K; Jagannathan, L; Raghavan, R; Bryan, R N; Miller, G A

    1997-01-01

    For the purpose of developing multiple, complementary, fully labeled electronic brain atlases and an atlas-based neuroimaging system for analysis, quantification, and real-time manipulation of cerebral structures in two and three dimensions, we have digitized, enhanced, segmented, and labeled the following print brain atlases: Co-Planar Stereotaxic Atlas of the Human Brain by Talairach and Tournoux, Atlas for Stereotaxy of the Human Brain by Schaltenbrand and Wahren, Referentially Oriented Cerebral MRI Anatomy by Talairach and Tournoux, and Atlas of the Cerebral Sulci by Ono, Kubik, and Abernathey. Three-dimensional extensions of these atlases have been developed as well. All two- and three-dimensional atlases are mutually preregistered and may be interactively registered with an actual patient's data. An atlas-based neuroimaging system has been developed that provides support for reformatting, registration, visualization, navigation, image processing, and quantification of clinical data. The anatomical index contains about 1,000 structures and over 400 sulcal patterns. Several new applications of the brain atlas database also have been developed, supported by various technologies such as virtual reality, the Internet, and electronic publishing. Fusion of information from multiple atlases assists the user in comprehensively understanding brain structures and identifying and quantifying anatomical regions in clinical data. The multiple brain atlas database and atlas-based neuroimaging system have substantial potential impact in stereotactic neurosurgery and radiotherapy by assisting in visualization and real-time manipulation in three dimensions of anatomical structures, in quantitative neuroradiology by allowing interactive analysis of clinical data, in three-dimensional neuroeducation, and in brain function studies. PMID:9148878

  1. Potential for New Phenomena in Dijet Events with the ATLAS Detector at $\\sqrt{s}=13$ TeV

    CERN Document Server

    Dandoy, Jeffrey Rogers; The ATLAS collaboration

    2015-01-01

    With the start of Run II of the Large Hadron Collider (LHC), pp collisions at the center of mass energy of 13 TeV will open a great potential for observing physics beyond the Standard Model (SM). New physics beyond the Standard Model (BSM) could couple to the strong force, making searches in jet events extremely exciting. The increase in center of mass energy greatly enhances the reach of searches using dijet events. Shortly after the start of data taking, the sensitivity to new heavy resonant particles will surpass the limits set with the full Run I dataset. The ability to observe non-resonant deviations from the SM such as structure within quarks themselves is also greatly enhanced from the new operating conditions of the LHC. The discovery potential of new physics is presented for both resonant and non-resonant new physics in dijet events.

  2. A potential source for cellulolytic enzyme discovery and environmental aspects revealed through metagenomics of Brazilian mangroves.

    Science.gov (United States)

    Thompson, Claudia Elizabeth; Beys-da-Silva, Walter Orlando; Santi, Lucélia; Berger, Markus; Vainstein, Marilene Henning; Guima Rães, Jorge Almeida; Vasconcelos, Ana Tereza Ribeiro

    2013-01-01

    The mangroves are among the most productive and biologically important environments. The possible presence of cellulolytic enzymes and microorganisms useful for biomass degradation as well as taxonomic and functional aspects of two Brazilian mangroves were evaluated using cultivation and metagenomic approaches. From a total of 296 microorganisms with visual differences in colony morphology and growth (including bacteria, yeast and filamentous fungus), 179 (60.5%) and 117 (39.5%) were isolated from the Rio de Janeiro (RJ) and Bahia (BA) samples, respectively. RJ metagenome showed the higher number of microbial isolates, which is consistent with its most conserved state and higher diversity. The metagenomic sequencing data showed similar predominant bacterial phyla in the BA and RJ mangroves with an abundance of Proteobacteria (57.8% and 44.6%), Firmicutes (11% and 12.3%) and Actinobacteria (8.4% and 7.5%). A higher number of enzymes involved in the degradation of polycyclic aromatic compounds were found in the BA mangrove. Specific sequences involved in the cellulolytic degradation, belonging to cellulases, hemicellulases, carbohydrate binding domains, dockerins and cohesins were identified, and it was possible to isolate cultivable fungi and bacteria related to biomass decomposition and with potential applications for the production of biofuels. These results showed that the mangroves possess all fundamental molecular tools required for building the cellulosome, which is required for the efficient degradation of cellulose material and sugar release.

  3. Searches for new physics in jet final states in ATLAS at LHC Run II

    CERN Document Server

    Amadio, Brian Thomas; The ATLAS collaboration

    2016-01-01

    The significant increase of the center-of-mass energy from 8 to 13 TeV at LHC Run II offers a great discovery potential for new physics at high mass, especially for strongly produced high-mass resonances, contact interactions, and TeV-gravity phenomena with high-pT jets. This talk presents the most recent Run II results from ATLAS on new physics searches in jet final states.

  4. Virtual Visit to the ATLAS Control Room by the Science Fest in Chicago

    CERN Multimedia

    ATLAS Experiment

    2012-01-01

    Particle physics allows us to understand the elementary constituents of all matter in the universe. Colliding particles at very high energy to a speed close to the speed of light, demonstrates that all matter on earth is made up of electrons and quarks and gluons, the substructure of protons and neutrons. Short films will present two of the main experiments at the Large Hadron Collider, the European Center for Nuclear Research, ATLAS and CMS, where protons collide at energies up to 7 tev, simulating a situation very close to the big bang. Discussions about the potential discoveries of the Higgs boson will be performed. Posters displayed will show the detectors at the LHC and at the Tevatron Fermilab in Chicago. A live video link with the CERN will be provided at 12:00 PM. http://atlas-live-virtual-visit.web.cern.ch/atlas-live-virtual-visit/2012/Chicago-2012.html

  5. Cross-correlation between the CMB lensing potential measured by Planck and high-z sub-mm galaxies detected by the Herschel-ATLAS survey

    CERN Document Server

    Bianchini, F; Lapi, A; Gonzalez-Nuevo, J; Baccigalupi, C; de Zotti, G; Danese, L; Bourne, N; Cooray, A; Dunne, L; Ivison, R; Maddox, S; Negrello, M; Valiante, E

    2014-01-01

    We present the first measurement of the correlation between the map of the CMB lensing potential derived from the Planck nominal mission data and $z >1.5$ galaxies detected by the Herschel-ATLAS (H-ATLAS) survey covering about $600\\,\\hbox{deg}^2$, i.e. about 1.4% of the sky. A highly significant ($20\\,\\sigma$) correlation is found, substantially stronger than expected. The result was checked by performing a number of null tests. The galaxy bias parameter, $b$, derived from a joint analysis of the cross-power spectrum and of the auto-power spectrum of the galaxy density contrast is found to be $b=2.80^{+0.12}_{-0.11}$, consistent with earlier estimates for H-ATLAS galaxies at similar redshifts. On the other hand, the amplitude of the cross-correlation is found to be a factor $1.62 \\pm 0.16$ higher than expected from the standard model and also found by cross-correlation analyses with other tracers of the large-scale structure. The enhancement due to lensing magnification can account for only a fraction of the ...

  6. Charged Higgs boson searches and SemiConductor Tracker commissioning for the ATLAS experiment

    CERN Document Server

    Mohn, Bjarte Alsaker

    The ATLAS (A Toroidal Lhc ApparatuS) experiment is one of four major experiments presently being installed at the upcoming Large Hadron Collider (LHC) at the European Centre for Nuclear Research (CERN) outside Geneva. In this thesis we present work done on both the simulation of the ATLAS physics potential for a charged Higgs boson and the construction of the Semiconductor Tracker (SCT) - a subdetector within the ATLAS Inner Detector. The discovery of a charged Higgs boson would be an unambiguous sign of physics beyond the Standard Model (SM) and it is thus of great interest to study the ATLAS potential for a charged Higgs discovery. Two such studies have been conducted for this thesis. In the first study a large-mass-splitting Minimal Supersymmetric Standard Model (MSSM) is assumed in which the charged Higgs boson decays into a W boson and a neutral Higgs may receive a large branching ratio.We conclude, however, that charged Higgs searches in this decay channel are made difficult by a large irreducible SM ba...

  7. Searches for New Physics in Unconventional Signatures at ATLAS

    CERN Document Server

    Otono, Hidetoshi; The ATLAS collaboration

    2016-01-01

    Various physics models predict new long-lived particles to be generated at the Large Hadron Collider, which leave unconventional signatures in the detectors. In order to maximise our discovery potential for new physics, the ATLAS experiment has developed novel analysis techniques for the long-lived particles. In these proceedings, a new result with $pp$ collisions at $\\sqrt s = 13~\\rm{TeV}$ in LHC Run 2 is presented, which exploits the ionisation energy loss measurements in the Pixel subsystem in the ATLAS detector to search for a massive charged long-lived particle with a velocity significantly below the speed of light. Several other characteristic searches performed with $pp$ collisions at $\\sqrt s = 7 - 8~\\rm{TeV}$ in LHC Run 1 are briefly summarised.

  8. Expected Performance of the ATLAS Experiment - Detector, Trigger and Physics

    Energy Technology Data Exchange (ETDEWEB)

    Aad, G.; Abat, E.; Abbott, B.; Abdallah, J.; Abdelalim, A.A.; Abdesselam, A.; Abdinov, O.; Abi, B.; Abolins, M.; Abramowicz, H.; Acharya, Bobby Samir; Adams, D.L.; Addy, T.N.; Adorisio, C.; Adragna, P.; Adye, T.; Aguilar-Saavedra, J.A.; Aharrouche, M.; Ahlen, S.P.; Ahles, F.; Ahmad, A.; /SUNY, Albany /Alberta U. /Ankara U. /Annecy, LAPP /Argonne /Arizona U. /Texas U., Arlington /Athens U. /Natl. Tech. U., Athens /Baku, Inst. Phys. /Barcelona, IFAE /Belgrade U. /VINCA Inst. Nucl. Sci., Belgrade /Bergen U. /LBL, Berkeley /Humboldt U., Berlin /Bern U., LHEP /Birmingham U. /Bogazici U. /INFN, Bologna /Bologna U.

    2011-11-28

    The Large Hadron Collider (LHC) at CERN promises a major step forward in the understanding of the fundamental nature of matter. The ATLAS experiment is a general-purpose detector for the LHC, whose design was guided by the need to accommodate the wide spectrum of possible physics signatures. The major remit of the ATLAS experiment is the exploration of the TeV mass scale where groundbreaking discoveries are expected. In the focus are the investigation of the electroweak symmetry breaking and linked to this the search for the Higgs boson as well as the search for Physics beyond the Standard Model. In this report a detailed examination of the expected performance of the ATLAS detector is provided, with a major aim being to investigate the experimental sensitivity to a wide range of measurements and potential observations of new physical processes. An earlier summary of the expected capabilities of ATLAS was compiled in 1999 [1]. A survey of physics capabilities of the CMS detector was published in [2]. The design of the ATLAS detector has now been finalised, and its construction and installation have been completed [3]. An extensive test-beam programme was undertaken. Furthermore, the simulation and reconstruction software code and frameworks have been completely rewritten. Revisions incorporated reflect improved detector modelling as well as major technical changes to the software technology. Greatly improved understanding of calibration and alignment techniques, and their practical impact on performance, is now in place. The studies reported here are based on full simulations of the ATLAS detector response. A variety of event generators were employed. The simulation and reconstruction of these large event samples thus provided an important operational test of the new ATLAS software system. In addition, the processing was distributed world-wide over the ATLAS Grid facilities and hence provided an important test of the ATLAS computing system - this is the origin of

  9. Distribution Atlas of Proliferating Bone Marrow in Non-Small Cell Lung Cancer Patients Measured by FLT-PET/CT Imaging, With Potential Applicability in Radiation Therapy Planning

    Energy Technology Data Exchange (ETDEWEB)

    Campbell, Belinda A., E-mail: Belinda.Campbell@petermac.org [Department of Radiation Oncology and Cancer Imaging, Peter MacCallum Cancer Centre, East Melbourne (Australia); Callahan, Jason [Centre for Molecular Imaging, Peter MacCallum Cancer Centre, East Melbourne (Australia); Bressel, Mathias [Centre for Biostatistics and Clinical Trials, Peter MacCallum Cancer Centre, East Melbourne (Australia); Simoens, Nathalie [Centre for Molecular Imaging, Peter MacCallum Cancer Centre, East Melbourne (Australia); Everitt, Sarah [Radiotherapy Services, Peter MacCallum Cancer Centre, East Melbourne (Australia); Hofman, Michael S.; Hicks, Rodney J. [Centre for Molecular Imaging, Peter MacCallum Cancer Centre, East Melbourne (Australia); Burbury, Kate [Department of Haematology, Peter MacCallum Cancer Centre, East Melbourne (Australia); MacManus, Michael [Department of Radiation Oncology and Cancer Imaging, Peter MacCallum Cancer Centre, East Melbourne (Australia)

    2015-08-01

    Purpose: Proliferating bone marrow is exquisitely sensitive to ionizing radiation. Knowledge of its distribution could improve radiation therapy planning to minimize unnecessary marrow exposure and avoid consequential prolonged myelosuppression. [18F]-Fluoro-3-deoxy-3-L-fluorothymidine (FLT)–positron emission tomography (PET) is a novel imaging modality that provides detailed quantitative images of proliferating tissues, including bone marrow. We used FLT-PET imaging in cancer patients to produce an atlas of marrow distribution with potential clinical utility. Methods and Materials: The FLT-PET and fused CT scans of eligible patients with non-small cell lung cancer (no distant metastases, no prior cytotoxic exposure, no hematologic disorders) were reviewed. The proportions of skeletal FLT activity in 10 predefined bony regions were determined and compared according to age, sex, and recent smoking status. Results: Fifty-one patients were studied: 67% male; median age 68 (range, 31-87) years; 8% never smokers; 70% no smoking in the preceding 3 months. Significant differences in marrow distribution occurred between sex and age groups. No effect was detected from smoking in the preceding 3 months. Using the mean percentages of FLT uptake per body region, we created an atlas of the distribution of functional bone marrow in 4 subgroups defined by sex and age. Conclusions: This atlas has potential utility for estimating the distribution of active marrow in adult cancer patients to guide radiation therapy planning. However, because of interindividual variation it should be used with caution when radiation therapy risks ablating large proportions of active marrow; in such cases, individual FLT-PET scans may be required.

  10. Distribution Atlas of Proliferating Bone Marrow in Non-Small Cell Lung Cancer Patients Measured by FLT-PET/CT Imaging, With Potential Applicability in Radiation Therapy Planning

    International Nuclear Information System (INIS)

    Purpose: Proliferating bone marrow is exquisitely sensitive to ionizing radiation. Knowledge of its distribution could improve radiation therapy planning to minimize unnecessary marrow exposure and avoid consequential prolonged myelosuppression. [18F]-Fluoro-3-deoxy-3-L-fluorothymidine (FLT)–positron emission tomography (PET) is a novel imaging modality that provides detailed quantitative images of proliferating tissues, including bone marrow. We used FLT-PET imaging in cancer patients to produce an atlas of marrow distribution with potential clinical utility. Methods and Materials: The FLT-PET and fused CT scans of eligible patients with non-small cell lung cancer (no distant metastases, no prior cytotoxic exposure, no hematologic disorders) were reviewed. The proportions of skeletal FLT activity in 10 predefined bony regions were determined and compared according to age, sex, and recent smoking status. Results: Fifty-one patients were studied: 67% male; median age 68 (range, 31-87) years; 8% never smokers; 70% no smoking in the preceding 3 months. Significant differences in marrow distribution occurred between sex and age groups. No effect was detected from smoking in the preceding 3 months. Using the mean percentages of FLT uptake per body region, we created an atlas of the distribution of functional bone marrow in 4 subgroups defined by sex and age. Conclusions: This atlas has potential utility for estimating the distribution of active marrow in adult cancer patients to guide radiation therapy planning. However, because of interindividual variation it should be used with caution when radiation therapy risks ablating large proportions of active marrow; in such cases, individual FLT-PET scans may be required

  11. Exploring the potential benefits of false discovery rates for region-based testing of association with rare genetic variation

    Directory of Open Access Journals (Sweden)

    ChangJiang eXu

    2014-01-01

    Full Text Available When analyzing the data arising from exome or whole-genome sequencing studies, window-based tests, i.e. tests that jointly analyze all genetic data in a small genomic region, are very popular. However, power is known to be quite low for finding associations with phenotypes using these tests, and hence a variety of analytic strategies may be employed to potentially improve power. Using sequencing data from all of chromosome 3 in an interim release of data on 2,432 individuals from the UK10K project, we simulated phenotypes associated with rare genetic variation, and used the results to explore the window-based test power, and to ask two specific questions. Firstly, we asked whether there could be substantial benefits associated with incorporating information from external annotation on the genetic variants, and secondly we asked whether the false discovery rate (FDRs would be a useful metric for assessing significance. Although, as expected, there are benefits to using additional information (such as annotation when it is associated with causality, we confirmed the general pattern of low sensitivity and power for window-based tests. At least for our chosen example, even when power is high to detect some associations, many of the regions containing causal variants cannot be detected, despite using lax significance thresholds and optimal analytic methods. Furthermore, our estimated FDR values tended to be much smaller than the true FDRs. Long-range correlations between variants—due to linkage disequilibrium—likely explains some of this bias. A more sophisticated approach to using the annotation information may help the power, but many causal variants of realistic effect sizes may simply be undetectable, at least with this sample size. Perhaps annotation information could assist in distinguishing windows containing causal variants from windows that are merely correlated with causal variants.

  12. ATLAS Installation: Building a Modern-day "Ship in a Bottle"

    CERN Multimedia

    Eisenstein, R

    By now, almost everyone connected with the ATLAS project is aware of its tremendously exciting discovery potential for physics. ATLAS is designed both to search for an as-yet-undiscovered piece of the Standard Model - the Higgs boson - as well as to search for indications of possible new physics - such as Supersymmetry - that lie beyond it. It is just this excitement that has propelled more than 2000 physicists, engineers, technical workers and students from all over the world to commit a significant part of their research careers to this massive undertaking. As the sub-detector components of ATLAS continue to arrive regularly here at CERN, the magnitude - and the quality - of that commitment has become very real. Actual objects exist, in building 180 and other places around the CERN site, waiting for installation into the ATLAS cavern, UX15. That installation will begin next April when ATLAS takes delivery of the experimental hall and associated other buildings and underground structures at Point 1. Indeed,...

  13. HiggsToFourLeptonsEV in the ATLAS EventView Analysis Framework

    CERN Document Server

    Lagouri, T; Del Peso, J

    2008-01-01

    ATLAS is one of the four experiments at the Large Hadron Collider (LHC) at CERN. This experiment has been designed to study a large range of physics topics, including searches for previously unobserved phenomena such as the Higgs Boson and super-symmetry. The physics analysis package HiggsToFourLeptonsEV for the Standard Model (SM) Higgs to four leptons channel with ATLAS is presented. The physics goal is to investigate with the ATLAS detector, the SM Higgs boson discovery potential through its observation in the four-lepton (electron and muon) final state. HiggsToFourLeptonsEV is based on the official ATLAS software ATHENA and the EventView (EV) analysis framework. EventView is a highly flexible and modular analysis framework in ATHENA and it is one of several analysis schemes for ATLAS physics user analysis. At the core of the EventView is the representative view of an event, which defines the contents of event data suitable for event-level physics analysis. The HiggsToFourLeptonsEV package prepares the dat...

  14. HiggsToFourLeptonsEV in the ATLAS EventView Analysis Framework

    CERN Document Server

    Lagouri, T; Del Peso, J

    2008-01-01

    ATLAS is one of the four experiments at the Large Hadron Collider (LHC) at CERN. This experiment has been designed to study a large range of physics topics, including searches for previously unobserved phenomena such as the Higgs Boson and super-symmetry. The physics analysis package HiggsToFourLeptonsEV for the Standard Model (SM) Higgs to four leptons channel with ATLAS is presented. The physics goal is to investigate with the ATLAS detector, the SM Higgs boson discovery potential through its observation in the four-lepton (electron and muon) final state. HiggsToFourLeptonsEV is based on the official ATLAS software ATHENA and the EventView (EV) analysis framework. EventView is a highly flexible and modular analysis framework in ATHENA and it is one of several analysis schemes for ATLAS physics user analysis. At the core of the EventView is the representative "view" of an event, which defines the contents of event data suitable for event-level physics analysis. The HiggsToFourLeptonsEV package, presented in ...

  15. Assessment and evaluation of geothermal potential in Switzerland; Atlas des ressources geothermiques suisses

    Energy Technology Data Exchange (ETDEWEB)

    Andenmatten-Berthoud, N. [Geowatt AG, Zuerich (Switzerland); Kohl, T. [Eidgenossische Technische Hochschule (ETH), Institut de Geophysique, Zuerich (Switzerland)

    2003-07-01

    This report for the Swiss Federal Office of Energy presents the first part of a project that aims at assessing the geothermal energy potential of Switzerland's underground. Due to the presence of the Alps the Swiss underground is highly heterogeneous with numerous geologic faults. Geothermal energy assessment has to be carried out region after region. The first steps consisted in collecting existing geological and hydrogeological data and finding out the best appropriate methodology. Analysis was restricted to the Northwest of Switzerland (Basle-Zurich area), which has a dense population - an important factor for future applications - and is better known than others, thanks to previous studies performed in conjunction with site pre-selection for future radioactive waste disposal facilities. In this area, sandstones and limestones are found on the crystalline bottom rock. Mathematical models and computer codes were developed for interpolation and extrapolation of local and regional data. Three dimensional finite-element techniques were used. The results are presented in diagrams and maps.

  16. CERN Open Days 2013, Point 1 - ATLAS: ATLAS Experiment

    CERN Multimedia

    CERN Photolab

    2013-01-01

    Stand description: The ATLAS Experiment at CERN is one of the largest and most complex scientific endeavours ever assembled. The detector, located at collision point 1 of the LHC, is designed to explore the fundamental components of nature and to study the forces that shape our universe. The past year’s discovery of a Higgs boson is one of the most important scientific achievements of our time, yet this is only one of many key goals of ATLAS. During a brief break in their journey, some of the 3000-member ATLAS collaboration will be taking time to share the excitement of this exploration with you. On surface no restricted access  The exhibit at Point 1 will give visitors a chance to meet these modern-day explorers and to learn from them how answers to the most fundamental questions of mankind are being sought. Activities will include a visit to the ATLAS detector, located 80m below ground; watching the prize-winning ATLAS movie in the ATLAS cinema; seeing real particle tracks in a cloud chamber and discussi...

  17. BioFuels Atlas (Presentation)

    Energy Technology Data Exchange (ETDEWEB)

    Moriarty, K.

    2011-02-01

    Presentation for biennial merit review of Biofuels Atlas, a first-pass visualization tool that allows users to explore the potential of biomass-to-biofuels conversions at various locations and scales.

  18. Solar energy potential atlas for planning energy system off-grid electrification in the Republic of Djibouti

    International Nuclear Information System (INIS)

    Highlights: ► First disaggregated solar atlas of Djibouti from satellite data. ► Supply energy to remote populations by using solar systems requires planning. ► Assessment of the O and SI SAF SSI satellite-based radiation model accuracy. ► Implementation of a DEM-based disaggregation methodology. ► Establishment of a solar radiation atlas for Djibouti energy management. - Abstract: Nowadays, energy supply of rural populations is one of the most important challenges in African developing countries, and more particularly in Sub-Saharan Africa. With only one third of the population connected to the grid and the high economical and environmental cost of classical energy resources, the use of renewable energies within the rural energy supply pattern is a reliable alternative solution to improve human development of remote populations. Djibouti is a little poor country of Sub-Saharan Africa which perfectly symbolizes this way of life. Electrification rate is only about 30% and the important scattering of rural peoples throughout the country makes grid extension and fuel transportation unsuitable economic solutions to carry energy. The geographically diffused solar resource can therefore be an interesting mean to produce energy where it is consumed. The aim of this study was the creation of the first Djibouti’s global horizontal irradiation atlas, including assessment and improvement. To realize this atlas, a satellite-derived irradiance model was used (EUMETSAT O and SI SAF). To validate this model over Djibouti, we installed two temporary weather stations during the year 2010 in Djibouti-city and Dikhil and we compared hourly, daily and monthly irradiation estimates against ground-based measurements. Results showed a good agreement between measures and estimates, with a maximum Relative Root Mean Squared Error (RRMSE) over the hourly solar atlas of 12.43% and 15.44%, for Dikhil and Djibouti-city respectively. In order to improve geographic information and

  19. Evaluating the potential of a novel oral lesion exudate collection method coupled with mass spectrometry-based proteomics for oral cancer biomarker discovery

    Directory of Open Access Journals (Sweden)

    Kooren Joel A

    2011-09-01

    Full Text Available Abstract Introduction Early diagnosis of Oral Squamous Cell Carcinoma (OSCC increases the survival rate of oral cancer. For early diagnosis, molecular biomarkers contained in samples collected non-invasively and directly from at-risk oral premalignant lesions (OPMLs would be ideal. Methods In this pilot study we evaluated the potential of a novel method using commercial PerioPaper absorbent strips for non-invasive collection of oral lesion exudate material coupled with mass spectrometry-based proteomics for oral cancer biomarker discovery. Results Our evaluation focused on three core issues. First, using an "on-strip" processing method, we found that protein can be isolated from exudate samples in amounts compatible with large-scale mass spectrometry-based proteomic analysis. Second, we found that the OPML exudate proteome was distinct from that of whole saliva, while being similar to the OPML epithelial cell proteome, demonstrating the fidelity of our exudate collection method. Third, in a proof-of-principle study, we identified numerous, inflammation-associated proteins showing an expected increase in abundance in OPML exudates compared to healthy oral tissue exudates. These results demonstrate the feasibility of identifying differentially abundant proteins from exudate samples, which is essential for biomarker discovery studies. Conclusions Collectively, our findings demonstrate that our exudate collection method coupled with mass spectrometry-based proteomics has great potential for transforming OSCC biomarker discovery and clinical diagnostics assay development.

  20. Cloud Atlas: Discovery of Patchy Clouds and High-amplitude Rotational Modulations In a Young, Extremely Red L-type Brown Dwarf

    CERN Document Server

    Lew, Ben W P; Zhou, Yifan; Schneider, Glenn; Burgasser, Adam J; Karalidi, Theodora; Yang, Hao; Marley, Mark S; Cowan, N B; Bedin,; R., L; Metchev, Stanimir A; Radigan, Jacqueline; Lowrance, Patrick J

    2016-01-01

    Condensate clouds fundamentally impact the atmospheric structure and spectra of exoplanets and brown dwarfs but the connections between surface gravity, cloud structure, dust in the upper atmosphere, and the red colors of some brown dwarfs remain poorly understood. Rotational modulations enable the study of different clouds in the same atmosphere, thereby providing a method to isolate the effects of clouds. Here we present the discovery of high peak-to-peak amplitude (8%) rotational modulations in a low-gravity, extremely red (J-Ks=2.55) L6 dwarf WISEP J004701.06+680352.1 (W0047). Using the Hubble Space Telescope (HST) time-resolved grism spectroscopy we find a best-fit rotational period (13.20$\\pm$0.14 hours) with a larger amplitude at 1.1 micron than at 1.7 micron. This is the third largest near-infrared variability amplitude measured in a brown dwarf, demonstrating that large-amplitude variations are not limited to the L/T transition but are present in some extremely red L-type dwarfs. We report a tentativ...

  1. ATLAS fast physics monitoring

    Indian Academy of Sciences (India)

    Karsten Köneke; on behalf of the ATLAS Collaboration

    2012-11-01

    The ATLAS experiment at the Large Hadron Collider is recording data from proton–proton collisions at a centre-of-mass energy of 7 TeV since the spring of 2010. The integrated luminosity has grown nearly exponentially since then and continues to rise fast. The ATLAS Collaboration has set up a framework to automatically process the rapidly growing dataset and produce performance and physics plots for the most interesting analyses. The system is designed to give fast feedback. The histograms are produced within hours of data reconstruction (2–3 days after data taking). Hints of potentially interesting physics signals obtained this way are followed up by physics groups.

  2. Prospects for the detection of the chargino-neutralino direct production with the ATLAS detector at the LHC

    CERN Document Server

    AUTHOR|(CDS)2070160; Roberto, F

    2007-01-01

    The Large Hadron Collider (LHC), currently under installation at CERN, is designed to provide high-energy proton collisions at the TeV energy scale, with a large instantaneous luminosity. This will allow to explore an energy region never reached by the previous accelerators and to search for new physics, also beyond the Standard Model (SM), as expected by a wide range of models. ATLAS (A Toroidal LHC Apparatus) is one of the four experiments which will be installed at the LHC. It is a general-purpose experiment which address the investigation of the full discovery potential provided by the LHC. Chapter 1 is dedicated to the description of the accelerator, the ATLAS experiment and its discovery capabilities. ATLAS is a large and complex experiment, accounting roughly $10^8$ electronic channels. Its trigger and data acquisition systems will be able to select and save few interesting events in between millions. Hence, to bring ATLAS to its maximum performances, a complete and effective monitoring system, able to...

  3. Electrons and Photons at ATLAS

    CERN Document Server

    Heim, Sarah; The ATLAS collaboration

    2016-01-01

    The performance of the reconstruction, calibration and identification of electrons and photons with the ATLAS detector at the LHC is a key component to realize the ATLAS full physics potential, both in the searches for new physics and in precision measurements. The algorithms used for the reconstruction and identification of electrons and photons with the ATLAS detector during LHC run 2 are presented. Measurements of the identification efficiencies are derived from data. The results from the 2015 pp collision data set at sqrt(s)=13 TeV are reported. The electron and photon energy calibration procedure and its performance are also discussed.

  4. Cloud Atlas: Discovery of Patchy Clouds and High-amplitude Rotational Modulations in a Young, Extremely Red L-type Brown Dwarf

    Science.gov (United States)

    Lew, Ben W. P.; Apai, Daniel; Zhou, Yifan; Schneider, Glenn; Burgasser, Adam J.; Karalidi, Theodora; Yang, Hao; Marley, Mark S.; Cowan, Nicolas B.; Bedin, Luigi R.; Metchev, Stanimir A.; Radigan, Jacqueline; Lowrance, Patrick J.

    2016-10-01

    Condensate clouds fundamentally impact the atmospheric structure and spectra of exoplanets and brown dwarfs, but the connections between surface gravity, cloud structure, dust in the upper atmosphere, and the red colors of some brown dwarfs remain poorly understood. Rotational modulations enable the study of different clouds in the same atmosphere, thereby providing a method to isolate the effects of clouds. Here, we present the discovery of high peak-to-peak amplitude (8%) rotational modulations in a low-gravity, extremely red (J-K s = 2.55) L6 dwarf WISEP J004701.06+680352.1 (W0047). Using the Hubble Space Telescope (HST) time-resolved grism spectroscopy, we find a best-fit rotational period (13.20 ± 0.14 hr) with a larger amplitude at 1.1 μm than at 1.7 μm. This is the third-largest near-infrared variability amplitude measured in a brown dwarf, demonstrating that large-amplitude variations are not limited to the L/T transition but are present in some extremely red L-type dwarfs. We report a tentative trend between the wavelength dependence of relative amplitude, possibly proxy for small dust grains lofted in the upper atmosphere, and the likelihood of large-amplitude variability. By assuming forsterite as a haze particle, we successfully explain the wavelength-dependent amplitude with submicron-sized haze particle sizes of around 0.4 μm. W0047 links the earlier spectral and later spectral type brown dwarfs in which rotational modulations have been observed; the large amplitude variations in this object make this a benchmark brown dwarf for the study of cloud properties close to the L/T transition.

  5. Supporting ATLAS

    CERN Multimedia

    maximilien brice

    2003-01-01

    Eighteen feet made of stainless steel will support the barrel ATLAS detector in the cavern at Point 1. In total, the ATLAS feet system will carry approximately 6000 tons, and will give the same inclination to the detector as the LHC accelerator.

  6. Supporting ATLAS

    CERN Multimedia

    2003-01-01

    Eighteen feet made of stainless steel will support the barrel ATLAS detector in the cavern at Point 1. In total, the ATLAS feet system will carry approximately 6000 tons, and will give the same inclination to the detector as the LHC accelerator. The installation of the feet is scheduled to finish during January 2004 with an installation precision at the 1 mm level despite their height of 5.3 metres. The manufacture was carried out in Russia (Company Izhorskiye Zavody in St. Petersburg), as part of a Russian and JINR Dubna in-kind contribution to ATLAS. Involved in the installation is a team from IHEP-Protvino (Russia), the ATLAS technical co-ordination team at CERN, and the CERN survey team. In all, about 15 people are involved. After the feet are in place, the barrel toroid magnet and the barrel calorimeters will be installed. This will keep the ATLAS team busy for the entire year 2004.

  7. Preparation of the ATLAS experiment in the LHC proton collider, performances of the electromagnetic calorimeter and its potentialities for the top quark; Preparation de l'experience ATLAS aupres du futur grand collisionneur de protons LHC: performances du calorimetre electromagnetique et potentiels pour la physique du quark top

    Energy Technology Data Exchange (ETDEWEB)

    Hubaut, F

    2007-03-15

    ATLAS is the biggest and the more complex detector ever built, it will operate on the LHC and is the outcome of a huge international collaboration of 2000 physicists. This document reviews the theoretical and experimental achievements of one of them, his collaboration spread over 7 years and has followed 2 axis. First, the design, construction and test of the electromagnetic calorimeter of ATLAS and secondly, the development of analysis strategies in the physics of the top quark. The expected important production of top quarks in LHC will allow an accurate measurement of the properties of this particle and in the same way will provide new testing areas for the standard model. The top quark, being extremely massive, might play a significant role in the mechanism of electro-weak symmetry breaking. This document is organized into 5 chapters: 1) ATLAS detector, performance and progress, 2) the optimization of the energy measurement with the electromagnetic calorimeter, 3) the performance of the electromagnetic calorimeter, 4) the physics of the top quark, and 5) the potentialities of ATLAS in the top quark sector. This document presented before an academic board will allow its author to manage research works and particularly to tutor thesis students. (A.C.)

  8. The ATLAS Education and Outreach Group

    CERN Multimedia

    M. Barnett

    With the unprecedented scale and duration of ATLAS and the unique possibilities to make groundbreaking discoveries in physics, ATLAS has special opportunities to communicate the importance and role of our accomplishments. We want to participate in educating the next generation of scientific and other leaders in our society by involving students of many levels in our research. The Education and Outreach Group has focused on producing informational material of various sorts - like brochures, posters, a film, animations and a public website - to assist the members of the collaboration in their contacts with students, teachers and the general public. Another aim is to facilitate the teaching of particle physics and particularly the role of the ATLAS Experiment by providing ideas and educational material. The Education and Outreach Group meets every ATLAS week, with an attendance of between 25 and 40 people. The meetings have become an interesting forum for education and outreach projects and new ideas. The comi...

  9. Studies of b-associated production and muonic decays of neutral Higgs bosons at the ATLAS experiment within the Minimal Supersymmetric Standard Model

    Energy Technology Data Exchange (ETDEWEB)

    Warsinsky, Markus

    2008-09-15

    This thesis presents a Monte Carlo study of neutral Higgs bosons of the Minimal Supersymmetric Standard Model (MSSM) decaying into muons at the ATLAS experiment at the CERN Large Hadron Collider. Signal and background processes are simulated using novel Monte Carlo generators that incorporate parts of higher order corrections and are expected to give a more accurate prediction than previous programs. The SHERPA Monte Carlo generator is validated for its use in the analysis and compared to results obtained with other programs. Where possible, the Monte Carlo event samples are normalized to higher order calculations. To increase the available Monte Carlo statistics, this study is based on the ATLAS fast detector simulation ATLFAST. Differences between ATLFAST and the detailed detector simulation of ATLAS are examined, and, where possible, correction procedures are devised. A cut based analysis is performed assuming an integrated luminosity of 30 fb{sup -1}, and optimized with respect to the discovery potential for MSSM Higgs bosons. The systematic uncertainties of the event selection and the Monte Carlo predictions are estimated. A method that can be used to estimate the background from data is presented and evaluated. Last, the discovery potential of the ATLAS experiment in the CP conserving benchmark scenarios of the MSSM is evaluated. One or more of the neutral Higgs bosons of the MSSM can be discovered in the muonic decay mode using 30 fb{sup -1} of data for low masses of the pseudoscalar boson A{sup 0}, if the model parameter tan {beta} is at least 20. For higher masses of the A{sup 0}, tan {beta} would need to be significantly higher to ensure a discovery in the studied decay channel. The sensitivity of ATLAS to MSSM Higgs bosons is multiple times larger than the one of previous and currently running experiments. (orig.)

  10. ATLAS helps shed light on the retina

    CERN Multimedia

    2007-01-01

    Technology developed for high-energy physics has led to the discovery of a retinal cell that eluded biologists for 40 years. The 512 electrode array, inspired by silicon microstrip detector technology in ATLAS, records the electrical activity of retinal neurones.ATLAS expertise have crossed over to biology enabling the discovery of a retinal cell type that may help humans see motion. The research, carried out by ATLAS collaborators at the University of California, Santa Cruz, and by neurobiologists at the Salk Institute in La Jolla, California, appeared in the 10 October issue of the Journal of Neuroscience and may help open biologists’ eyes to the uses of techniques developed in high-energy physics. At least 22 different types of primate retinal output cell are known from anatomical studies, but the functions of only a handful of these have been determined. The cells discovered have been ca...

  11. Speckle Interferometry and a Study of $\\Gamma_W$ for the ATLAS Experiment

    CERN Document Server

    Buira-Clark, D C

    2006-01-01

    The ATLAS experiment is being assembeled as a general purpose particle detector to exploit the physics discovery potential of the Large Hadron Collider. The SemiConductor Tracker (SCT), one of the central subsystems of ATLAS, requires alignment of O(10μm) for good performance. The alignment program consists of a set of proceedures to establish the location of detector elements. This includes optimised design and construction prior to operation. This thesis describes Electronic Speckle Pattern Interferometry (ESPI), a technique used to measure deformation at the micron level which has been applied to SCT components during design and prototype development. ESPI creates contour maps of objects under study, helping a qualitative understanding of object behaviour as well as providing measurements. ESPI measurements of the thermal deformation of SCT detector modules are presented. A modified ESPI interferometer was developed to create contours of vibration amplitude. Tests were performed on well-understood objects...

  12. Atlas of gene expression in the developing kidney at microanatomic resolution.

    Science.gov (United States)

    Brunskill, Eric W; Aronow, Bruce J; Georgas, Kylie; Rumballe, Bree; Valerius, M Todd; Aronow, Jeremy; Kaimal, Vivek; Jegga, Anil G; Yu, Jing; Grimmond, Sean; McMahon, Andrew P; Patterson, Larry T; Little, Melissa H; Potter, S Steven

    2008-11-01

    Kidney development is based on differential cell-type-specific expression of a vast number of genes. While multiple critical genes and pathways have been elucidated, a genome-wide analysis of gene expression within individual cellular and anatomic structures is lacking. Accomplishing this could provide significant new insights into fundamental developmental mechanisms such as mesenchymal-epithelial transition, inductive signaling, branching morphogenesis, and segmentation. We describe here a comprehensive gene expression atlas of the developing mouse kidney based on the isolation of each major compartment by either laser capture microdissection or fluorescence-activated cell sorting, followed by microarray profiling. The resulting data agree with known expression patterns and additional in situ hybridizations. This kidney atlas allows a comprehensive analysis of the progression of gene expression states during nephrogenesis, as well as discovery of potential growth factor-receptor interactions. In addition, the results provide deeper insight into the genetic regulatory mechanisms of kidney development. PMID:19000842

  13. Mongolian Atlas

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Climatic atlas dated 1985, in Mongolian, with introductory material also in Russian and English. One hundred eight pages in single page PDFs.

  14. Evolutionary and geological factors controlling endogenic uranium mineralization and the potential for the discovery of new ore districts

    Science.gov (United States)

    Mashkovtsev, G. A.; Miguta, A. K.; Shchetochkin, V. N.

    2015-03-01

    The exhaustion of known surface and near-surface high-grade uranium deposits poses the serious problem of prospecting and exploration of new large endogenic deposits. A comparison of large data sets for endogenic deposits from the world's major uranium districts allowed the authors to develop an evolutionary geological model of large-scale uranium ore genesis, which reflects the succession and nature of preore, ore-forming, and post-ore processes. The study reveals a combination of general (recurrent) factors controlling the formation of ore districts with large-scale uranium mineralization regardless of the genesis and timing of the mineralization. At the same time, these factors depend on the regional setting and can vary considerably among deposits of the same type localized in different tectonic blocks with different characteristics and structural evolution. In connection with this, the exploration of major genetic types of deposits requires the application of specified criteria. Along with the consideration of the evolutionary geological model of ore formation, the study discusses a variety of tectono-magmatic, mineralogical, geochemical, radiogeochemical, and physicochemical factors and indications in three uranium districts (the Streltsovskoe, Elkon, and Central Ukrainian districts), which can form the basis for further uranium prospecting and exploration. Using a combination of favorable prerequisite conditions the study compares the possibilities for the discovery of large endogenic uranium deposits in several regions of Russia.

  15. Development of a benchmark parameter scan for Higgs bosons in the NMSSM Model and a study of the sensitivity for H{yields}AA{yields}4{tau} in vector boson fusion with the ATLAS detector

    Energy Technology Data Exchange (ETDEWEB)

    Rottlaender, Iris

    2008-08-15

    An evaluation of the discovery potential for NMSSM Higgs bosons of the ATLAS experiment at the LHC is presented. For this purpose, seven two-dimensional benchmark planes in the six-dimensional parameter space of the NMSSM Higgs sector are defined. These planes include different types of phenomenology for which the discovery of NMSSM Higgs bosons is especially challenging and which are considered typical for the NMSSM. They are subsequently used to give a detailed evaluation of the Higgs boson discovery potential based on Monte Carlo studies from the ATLAS collaboration. Afterwards, the possibility of discovering NMSSM Higgs bosons via the H{sub 1}{yields}A{sub 1}A{sub 1}{yields}4{tau}{yields}4{mu}+8{nu} decay chain and with the vector boson fusion production mode is investigated. A particular emphasis is put on the mass reconstruction from the complex final state. Furthermore, a study of the jet reconstruction performance at the ATLAS experiment which is of crucial relevance for vector boson fusion searches is presented. A good detectability of the so-called tagging jets that originate from the scattered partons in the vector boson fusion process is of critical importance for an early Higgs boson discovery in many models and also within the framework of the NMSSM. (orig.)

  16. ATLAS: Forecasting Falling Rocks

    Science.gov (United States)

    Heinze, Aren; Tonry, John L.; Denneau, Larry; Stalder, Brian; Sherstyuk, Andrei

    2016-10-01

    The Asteroid Terrestrial-impact Last Alert System (ATLAS) is a new asteroid survey aimed at detecting small (10-100 meter) asteroids inbound for impact with Earth. Relative to the larger objects targeted by most surveys, these small asteroids pose very different threats to our planet. Large asteroids can be seen at great distances and measured over many years, resulting in precise orbits that enable long-term impact predictions. If an impact were predicted, a costly deflection mission would be warranted to avert global catastrophe -- but a large asteroid impact is very unlikely in the next century. By contrast, impacts from small asteroids are inevitable. Such objects can be detected only during close encounters with Earth -- encounters too brief to yield long-term predictions. Only a few days' warning could be expected for an impactor in the 10-100 meter range, but fortunately the impact of such an asteroid would cause only regional damage. As in the case of a hurricane, a quixotic attempt to deflect or destroy it would be more expensive than the damage from its impact. A better response is to save human lives by evacuating the impact zone, and then rebuild. Only a few days warning are needed for this purpose, and ATLAS is unique among asteroid surveys in being optimized to provide it. While the optimization has many facets, the most important is rapidly surveying the entire accessible sky. A small asteroid could come from any direction and go from invisibility to impact in less than a week: ATLAS must look everywhere, all the time. Sky coverage is more important than exquisite sensitivity to faint objects, because asteroids inbound for impact will eventually become quite bright. This makes ATLAS complementary to other surveys, which scan the sky at a more leisurely pace but are able to detect asteroids at greater distances. We report on ATLAS' first year of survey operations, including the maturing of robotic observation and detection strategies, and asteroid and

  17. Prospects for Higgs Searches via VBF at the LHC with ATLAS

    CERN Document Server

    Mellado, B

    2004-01-01

    We report on the potential for the discovery of a Standard Model Higgs boson with the vector boson fusion mechanism in the mass range $115ATLAS experiment at the LHC. Feasibility studies at hadron level followed by a fast detector simulation have been performed for $H\\rightarrow W^{(*)}W^{(*)}\\rightarrow l^+l^-\\sla{p_T}$, $H\\rightarrow\\gamma\\gamma$ and $H\\rightarrow ZZ\\rightarrow l^+l^-q\\overline{q}$. The preliminary results obtained here show a large discovery potential in the range $115

  18. Windows on the brain: the emerging role of atlases and databases in neuroscience

    Science.gov (United States)

    Van Essen, David C.; VanEssen, D. C. (Principal Investigator)

    2002-01-01

    Brain atlases and associated databases have great potential as gateways for navigating, accessing, and visualizing a wide range of neuroscientific data. Recent progress towards realizing this potential includes the establishment of probabilistic atlases, surface-based atlases and associated databases, combined with improvements in visualization capabilities and internet access.

  19. Tau lepton reconstruction with energy flow and the search for R-parity violating supersymmetry at the ATLAS experiment

    Energy Technology Data Exchange (ETDEWEB)

    Fleischmann, Sebastian

    2012-10-15

    This thesis investigates the discovery potential of the ATLAS experiment at the Large Hadron Collider (LHC) for R-parity violating (RPV) supersymmetric (SUSY) models in the framework of mSUGRA, where the stau ({tau}) is the lightest supersymmetric particle (LSP). Hence, the LSP is charged and decays in contrast to R-parity conserving models. For the first time in the framework of this RPV model a detailed signal to background analysis is performed for a specific benchmark scenario using a full Monte Carlo simulation of the ATLAS detector. Furthermore a feasibility study for an estimate of the stau LSP mass is given. The fast track simulation FATRAS is a new approach for the Monte Carlo simulation of particles in the tracking systems of the ATLAS experiment. Its results are compared to first data at {radical}(s) = 900 GeV. Additionally, two generic detector simulations are compared to the full simulation. The reconstruction of tau leptons is crucial for many searches for new physics with ATLAS. Therefore, the reconstruction of tracks for particles from tau decays is studied. A novel method, PanTau, is presented for the tau reconstruction in ATLAS. It is based on the energy flow algorithm eflowRec. Its performance is evaluated in Monte Carlo simulations. The dependency of the identification variables on the jet energy are studied in detail. Finally, the energy flow quantities and the identification variables are compared between Monte Carlo simulations and measured multijet events with first ATLAS data at {radical}(s) = 7 TeV.

  20. The ATLAS Distributed Computing: the challenges of the future

    CERN Document Server

    Sakamoto, H; The ATLAS collaboration

    2013-01-01

    The ATLAS experiment has collected more than 25 fb-1 of data since LHC has started it's operation in 2010. Tens of petabytes of collision events and Monte-Carlo simulations are stored over more than 150 computing centers all over the world. The data processing is performed on grid sites providing more than 100.000 computing cores and orchestrated by the ATLAS in-house developed job and data management services. The discovery of the Higgs-like boson in 2012 would not be possible without the excellent performance of the ATLAS Distributed Computing. The future ATLAS experiment operation with increased LHC beam energy and luminosity foreseen for 2014 imposes a significant increase in computing demands the ATLAS Distributed Computing needs to satisfy. Therefore, a development of the new data-processing, storage and data-distribution systems has been started to efficiently use the computing resources exploiting current and future technologies of distributed computing.

  1. Spectroscopy of onia and hadrons with open beauty in ATLAS

    CERN Document Server

    Henderson, RCW; The ATLAS collaboration

    2015-01-01

    Results published by the ATLAS experiment at the LHC are presented. The ATLAS discovery of the $\\chi_b(3P)$ onia state is recalled and report the new observation of an excited open beauty hadronic state, a $B_c^{\\pm}$ meson with mass $6842 \\pm 4(stat) \\pm 5(syst)$ MeV consistent with expectations for the $B_c^{\\pm}(2S)$.

  2. Metatranscriptomics and pyrosequencing facilitate discovery of potential viral natural enemies of the invasive Caribbean crazy ant, Nylanderia pubens.

    Directory of Open Access Journals (Sweden)

    Steven M Valles

    Full Text Available BACKGROUND: Nylanderia pubens (Forel is an invasive ant species that in recent years has developed into a serious nuisance problem in the Caribbean and United States. A rapidly expanding range, explosive localized population growth, and control difficulties have elevated this ant to pest status. Professional entomologists and the pest control industry in the United States are urgently trying to understand its biology and develop effective control methods. Currently, no known biological-based control agents are available for use in controlling N. pubens. METHODOLOGY AND PRINCIPAL FINDINGS: Metagenomics and pyrosequencing techniques were employed to examine the transcriptome of field-collected N. pubens colonies in an effort to identify virus infections with potential to serve as control agents against this pest ant. Pyrosequencing (454-platform of a non-normalized N. pubens expression library generated 1,306,177 raw sequence reads comprising 450 Mbp. Assembly resulted in generation of 59,017 non-redundant sequences, including 27,348 contigs and 31,669 singlets. BLAST analysis of these non-redundant sequences identified 51 of potential viral origin. Additional analyses winnowed this list of potential viruses to three that appear to replicate in N. pubens. CONCLUSIONS: Pyrosequencing the transcriptome of field-collected samples of N. pubens has identified at least three sequences that are likely of viral origin and, in which, N. pubens serves as host. In addition, the N. pubens transcriptome provides a genetic resource for the scientific community which is especially important at this early stage of developing a knowledgebase for this new pest.

  3. Structure-based design, discovery and development of checkpoint kinase inhibitors as potential anti-cancer therapies

    Science.gov (United States)

    Matthews, Thomas P; Jones, Alan M; Collins, Ian

    2014-01-01

    Introduction Checkpoint kinase inhibitors offer the promise of enhancing the effectiveness of widely prescribed cancer chemotherapies and radiotherapy by inhibiting the DNA damage response, as well as the potential for single agent efficacy. Areas covered This article surveys structural insights into the checkpoint kinases CHK1 and CHK2 that have been exploited to enhance the selectivity and potency of small molecule inhibitors. The use of mechanistic cellular assays to guide the optimisation of inhibitors is reviewed. The status of the current clinical candidates and emerging new clinical contexts for CHK1 and CHK2 inhibitors are discussed, including the prospects for single agent efficacy. Expert opinion Protein bound water molecules play key roles in structural features that can be targeted to gain high selectivity for either enzyme. The results of early phase clinical trials of checkpoint inhibitors have been mixed, but significant progress has been made in testing the combination of CHK1 inhibitors with genotoxic chemotherapy. Second generation CHK1 inhibitors are likely to benefit from increased selectivity and oral bioavailability. While the optimum therapeutic context for CHK2 inhibition remains unclear, the emergence of single agent preclinical efficacy for CHK1 inhibitors in specific tumour types exhibiting constitutive replication stress represents exciting progress in exploring the therapeutic potential of these agents. PMID:23594139

  4. Volatility Discovery

    DEFF Research Database (Denmark)

    Dias, Gustavo Fruet; Scherrer, Cristina; Papailias, Fotis

    There is a large literature that investigates how homogenous securities traded on different markets incorporate new information (price discovery analysis). We extend this concept to the stochastic volatility process and investigate how markets contribute to the efficient stochastic volatility whi...

  5. MOLECULAR MODELING AND DRUG DISCOVERY OF POTENTIAL INHIBITORS FOR ANTICANCER TARGET GENE MELK (MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE

    Directory of Open Access Journals (Sweden)

    Sabitha. K

    2011-12-01

    Full Text Available Maternal embryonic leucine zipper kinase (MELK, a member of the AMP serine/threonine kinase family, exhibits multiple features consistent with the potential utility of this gene as an anticancer target. Reports show that MELK functions as a cancer-specific protein kinase, and that down-regulation of MELK results in growth suppression of breast cancer cells. There are many inhibitors which bind to kinases and are in clinical trials too. In our study we have taken a library of different inhibitors and docked those using GLIDE Induced Fit. From docking result we can conclude that Syk inhibitor II, Rho kinase inhibitor IV, p38 MAP Kinase Inhibitor III, HA 1004, Dihydrochloride and IKK -2 inhibitor VI have good binding affinity towards MELK and may have anticancer activity.

  6. Discovery of membrane active benzimidazole quinolones-based topoisomerase inhibitors as potential DNA-binding antimicrobial agents.

    Science.gov (United States)

    Zhang, Ling; Addla, Dinesh; Ponmani, Jeyakkumar; Wang, Ao; Xie, Dan; Wang, Ya-Nan; Zhang, Shao-Lin; Geng, Rong-Xia; Cai, Gui-Xin; Li, Shuo; Zhou, Cheng-He

    2016-03-23

    A series of novel benzimidazole quinolones as potential antimicrobial agents were designed and synthesized. Most of the prepared compounds exhibited good or even stronger antimicrobial activities in comparison with reference drugs. The most potent compound 15m was membrane active and did not trigger the development of resistance in bacteria. It not only inhibited the formation of biofilms but also disrupted the established Staphylococcus aureus and Escherichia coli biofilms. It was able to inhibit the relaxation activity of E. coli topoisomerase IV at 10 μM concentration. Moreover, this compound also showed low toxicity against mammalian cells. Molecular modeling and experimental investigation of compound 15m with DNA suggested that this compound could effectively bind with DNA to form a steady 15m-DNA complex which might further block DNA replication to exert the powerful bioactivities.

  7. ATLAS Virtual Visit-Chicago-14-05-2014

    CERN Multimedia

    2014-01-01

    The Consulate General of France in Chicago organizes a third whole day for the discovery of science by students, in downtown Chicago, through hands-on activities. This event is designed for both American and French students from 5th to 10th grade and their teachers. One of the highlight will be a direct connevtion with the ATLAS experiment at CERN, Switzerland. - See more at: http://atlas-live-virtual-visit.web.cern.ch/atlas-live-virtual-visit/2014/Chicago-2-2014.html#sthash.EGd2sTp0.dpuf

  8. A new approach for potential drug target discovery through in silico metabolic pathway analysis using Trypanosoma cruzi genome information

    Directory of Open Access Journals (Sweden)

    Marcelo Alves-Ferreira

    2009-12-01

    Full Text Available The current drug options for the treatment of chronic Chagas disease have not been sufficient and high hopes have been placed on the use of genomic data from the human parasite Trypanosoma cruzi to identify new drug targets and develop appropriate treatments for both acute and chronic Chagas disease. However, the lack of a complete assembly of the genomic sequence and the presence of many predicted proteins with unknown or unsure functions has hampered our complete view of the parasite's metabolic pathways. Moreover, pinpointing new drug targets has proven to be more complex than anticipated and has revealed large holes in our understanding of metabolic pathways and their integrated regulation, not only for this parasite, but for many other similar pathogens. Using an in silicocomparative study on pathway annotation and searching for analogous and specific enzymes, we have been able to predict a considerable number of additional enzymatic functions in T. cruzi. Here we focus on the energetic pathways, such as glycolysis, the pentose phosphate shunt, the Krebs cycle and lipid metabolism. We point out many enzymes that are analogous to those of the human host, which could be potential new therapeutic targets.

  9. Docking and Molecular Dynamics Simulations in Potential Drugs Discovery: An Application to Influenza Virus M2 Protein

    Directory of Open Access Journals (Sweden)

    Marine E. Bozdaganyan

    2014-01-01

    Full Text Available Molecular docking is a common method for searching new potential drugs. Improvement of the results of docking can be achieved by different ways-one of them is molecular dynamics simulations of protein-ligand complexes. As a model for our research we chose M2 membrane protein from influenza virus. M2 protein is a high selective tetrameric pH-gated proton channel. It was previously shown that Omeprazole Family Compounds (OFC block the "proton pump", though we hypothesized further that they could interfere with the mechanism of fusion of the virus envelope and endosomal membrane, thereby hindering the M2 proton pump mechanism of influenza viruses. We carried out a Molecular Dynamics (MD simulation in order to predict constant of binding for OFC. We simulated M2 Protein (PDB code 3C9J in complex with its ligands: Amantadine, rimantadine as positive controls and omeprazole as putative ligand. We made use of molecular docking as well as the thermodynamic integration method to estimate binding free energies of the ligands. We demonstrate that the thermodynamic integration method predicts free energies of ligand binding better than molecular docking while embedding of M2 protein in a membrane further improves the calculated free energy values. Free energy calculations imply omeprazole as a potent anti-viral drug.

  10. Clinical implications of basic science discoveries: nociceptive neurons as targets to control immunity--potential relevance for transplantation.

    Science.gov (United States)

    Larregina, A T; Divito, S J; Morelli, A E

    2015-06-01

    Increasing evidence indicates the existence of a complex cross-regulation between the most important biosensors of the human body: The immune and nervous systems. Cytokines control body temperature and trigger autoimmune disorders in the central nervous system, whereas neuropeptides released in peripheral tissues and lymphoid organs modulate inflammatory (innate) and adaptive immune responses. Surprisingly, the effects of nerve fibers and the antidromic release of its pro-inflammatory neuropeptides on the leukocytes of the immune system that mediate graft rejection are practically unknown. In the transplantation field, such area of research remains practically unexplored. A recent study by Riol-Blanco et al has revealed new details on how nociceptive nerves regulate the pro-inflammatory function of leukocytes in peripheral tissues. Although the mechanism(s) by which neuroinflammation affects the immune response against the allograft remains unknown, recent data suggest that this new area of research is worth exploring for potential development of novel complementary therapies for prevention/treatment of graft rejection.

  11. Molecular dynamics simulations of sonic hedgehog-receptor and inhibitor complexes and their applications for potential anticancer agent discovery.

    Directory of Open Access Journals (Sweden)

    Swan Hwang

    Full Text Available The sonic hedgehog (Shh signaling pathway is necessary for a variety of development and differentiation during embryogenesis as well as maintenance and renascence of diverse adult tissues. However, an abnormal activation of the signaling pathway is related to various cancers. In this pathway, the Shh signaling transduction is facilitated by binding of Shh to its receptor protein, Ptch. In this study, we modeled the 3D structure of functionally important key loop peptides of Ptch based on homologous proteins. Using this loop model, the molecular interactions between the structural components present in the pseudo-active site of Shh and key residues of Ptch was investigated in atomic level through molecular dynamics (MD simulations. For the purpose of developing inhibitor candidates of the Shh signaling pathway, the Shh pseudo-active site of this interface region was selected as a target to block the direct binding between Shh and Ptch. Two different structure-based pharmacophore models were generated considering the key loop of Ptch and known inhibitor-induced conformational changes of the Shh through MD simulations. Finally two hit compounds were retrieved through a series of virtual screening combined with molecular docking simulations and we propose two hit compounds as potential inhibitory lead candidates to block the Shh signaling pathway based on their strong interactions to receptor or inhibitor induced conformations of the Shh.

  12. The ATLAS experiment

    CERN Document Server

    Dunford, Monica Lynn

    2014-01-01

    In particle physics experiments, the discovery of increasingly more massive particles has brought deep understanding of the basic constituents of matter and of the fundamental forces among them. In order to explore Nature in its deepest elementary secrets, the Large Hadron Collider (LHC) was built at CERN, Geneva. The LHC provides the highest energy collisions in a laboratory, at very high rates to allow one to study very rare reactions. Two independent sophisticated huge instruments, called ATLAS and CMS detectors, are operated to explore in a most broad way the physics of these collisions. In addition to these two general-purpose detectors, smaller specialized experiments (LHCb, ALICE and some others) are collecting collision data as well.

  13. Discovery of potential drugs for human-infecting H7N9 virus containing R294K mutation

    Directory of Open Access Journals (Sweden)

    He JY

    2014-12-01

    Full Text Available Jiao-Yu He,1,* Cheng Li,2,* Guo Wu3 1College of Life Sciences and Key Laboratory for Bio-resources of Ministry of Education, Sichuan University, 2College of Agronomy, Sichuan Agricultural University, 3College of Life Sciences, Sichuan Normal University, Chengdu, People’s Republic of China *These authors contributed equally to this work Background: After the first epidemic wave from February through May 2013, the influenza A (H7N9 virus emerged and has followed a second epidemic wave since June 2013. As of June 27, 2014, the outbreak of H7N9 had caused 450 confirmed cases of human infection, with 165 deaths included. The case-fatality rate of all confirmed cases is about 36%, making the H7N9 virus a significant threat to people’s health. At present, neuraminidase inhibitors are the only licensed antiviral medications available to treat H7N9 infections in humans. Oseltamivir is the most commonly used inhibitor, and it is also a front-line drug for the threatening H7N9. Unfortunately, it has been reported that patients treated with oseltamivir can induce R294K (Arg294Lys substitution in the H7N9 virus, which is a rare mutation and can reduce the antiviral efficacy of inhibitors. Even worse, deaths caused by such mutation after oseltamivir treatment have already been reported, indicating that the need to find substitutive neuraminidase inhibitors for currently available drugs to treat drug-resistant H7N9 is really pressing.Materials and methods: First, the structure of H7N9 containing the R294K substitution was downloaded from the Protein Data Bank, and structural information of approved drugs was downloaded from the ZINC (ZINC Is Not Commercial database. Taking oseltamivir carboxylate as a reference drug, we then filtered these molecules through virtual screening to find out potential inhibitors targeting the mutated H7N9 virus. For further evaluation, we carried out a 14 ns molecular dynamic simulation for each H7N9–drug complex and

  14. Screening Method for the Discovery of Potential Bioactive Cysteine-Containing Peptides Using 3D Mass Mapping

    Science.gov (United States)

    van Oosten, Luuk N.; Pieterse, Mervin; Pinkse, Martijn W. H.; Verhaert, Peter D. E. M.

    2015-12-01

    Animal venoms and toxins are a valuable source of bioactive peptides with pharmacologic relevance as potential drug leads. A large subset of biologically active peptides discovered up till now contain disulfide bridges that enhance stability and activity. To discover new members of this class of peptides, we developed a workflow screening specifically for those peptides that contain inter- and intra-molecular disulfide bonds by means of three-dimensional (3D) mass mapping. Two intrinsic properties of the sulfur atom, (1) its relatively large negative mass defect, and (2) its isotopic composition, allow for differentiation between cysteine-containing peptides and peptides lacking sulfur. High sulfur content in a peptide decreases the normalized nominal mass defect (NMD) and increases the normalized isotopic shift (NIS). Hence in a 3D plot of mass, NIS, and NMD, peptides with sulfur appear in this plot with a distinct spatial localization compared with peptides that lack sulfur. In this study we investigated the skin secretion of two frog species; Odorrana schmackeri and Bombina variegata. Peptides from the crude skin secretions were separated by nanoflow LC, and of all eluting peptides high resolution zoom scans were acquired in order to accurately determine both monoisotopic mass and average mass. Both the NMD and the NIS were calculated from the experimental data using an in-house developed MATLAB script. Candidate peptides exhibiting a low NMD and high NIS values were selected for targeted de novo sequencing, and this resulted in the identification of several novel inter- and intra-molecular disulfide bond containing peptides.

  15. Cosmic gamma ray detection and discovery potential with the AMS-2 spectrometer; Detection de rayons {gamma} cosmiques et potentiel de decouvertes avec le spectrometre AMS-02

    Energy Technology Data Exchange (ETDEWEB)

    Girard, L

    2004-12-15

    Yet designed to measure charged component of the cosmic rays, the foreseen Alpha Magnetic Spectrometer (AMS-02) could also release {gamma}-ray studies, in the energy range from GeV to TeV, using the tracker system, for {gamma}-rays converted in e{sup +}e{sup -} pair, and the electromagnetic calorimeter. In the first part of the thesis are described the calibrations and the performances of the engineering model of the calorimeter, obtained from the analysis of data taken during a test-beam performed at CERN in July 2002. In the second part of the thesis, the AMS-02 discovery potential for {gamma}-astrophysics is presented. While exposure maps of the {gamma}--sky are computed for one year of data taking with the {gamma}--detectors, the acceptance of the calorimeter is obtained from Monte-Carlo simulations. The AMS-02 potential is then estimated for signals from the Vela pulsar and for some supersymmetric signals from the Galactic Center. (author)

  16. Search for the Higgs Boson in the Channel H->ZZ*->4l with the ATLAS Detector

    CERN Document Server

    Rebuzzi, D; The ATLAS collaboration

    2009-01-01

    The decay channel H->ZZ*->4l provides a clean signature for the Higgs boson in the mass range between ~120 GeV and 2MZ, above which the "gold-plated" channel with two real Z bosons in the final state opens up. The signal cross section is several orders of magnitude smaller than those for the backgrounds, therefore a thorough understanding of the multi-lepton processes is needed to obtain a high background rejection. Crucial for this channel is also a very good knowledge of the trigger and detector response for lepton identification and reconstruction. The observability of the signal on top of the reducible tt, Zbb and of the irreducible ZZz backgrounds with the ATLAS Detector is discussed in the following, with particular emphasis on lepton reconstruction. The ATLAS discovery potential for the H->4l, including the most realistic and up-to-date description of the detector performance, is presented.

  17. Proteomics-Based Characterization of the Humoral Immune Response in Sporotrichosis: Toward Discovery of Potential Diagnostic and Vaccine Antigens.

    Directory of Open Access Journals (Sweden)

    Anderson Messias Rodrigues

    understanding of the coevolution of Sporothrix and its warm-blooded hosts. We propose that 3-carboxymuconate cyclase has potential for the serological diagnosis of sporotrichosis and as target for the development of an effective multi-species vaccine against sporotrichosis in animals and humans.

  18. Amniotic fluid cathelicidin in PPROM pregnancies: from proteomic discovery to assessing its potential in inflammatory complications diagnosis.

    Directory of Open Access Journals (Sweden)

    Vojtech Tambor

    Full Text Available BACKGROUND: Preterm prelabor rupture of membranes (PPROM complicated by microbial invasion of the amniotic cavity (MIAC leading to histological chorioamnionitis (HCA significantly impacts perinatal morbidity. Unfortunately, no well-established tool for identifying PPROM patients threatened by these disorders is available. METHODOLOGY/PRINCIPAL FINDINGS: We performed an unbiased exploratory analysis of amniotic fluid proteome changes due to MIAC and HCA. From among the top five proteins that showed the most profound and significant change, we sought to confirm results concerning cathelicidin (P49913, CAMP_HUMAN, since an ELISA kit was readily available for this protein. In our exploratory proteomic study, cathelicidin showed a ∼6-fold higher concentration in PPROM patients with confirmed MIAC and HCA. We verified significantly higher levels of cathelicidin in exploratory samples (women without both MIAC and HCA: median 1.4 ng/ml; women with both conditions confirmed: median 3.6 ng/ml; p = 0.0003. A prospective replication cohort was used for independent validation and for assessment of cathelicidin potential to stratify women with MIAC leading to HCA from women in whom at least one of these conditions was ruled out. We confirmed the association of higher amniotic fluid cathelicidin levels with MIAC leading to HCA (the presence of both MIAC and HCA: median 3.1 ng/ml; other women: median 1.4 ng/ml; p<0.0001. A cathelicidin concentration of 4.0 ng/ml was found to be the best cut-off point for identifying PPROM women with both MIAC and HCA. When tested on the validation cohort, a sensitivity of 48%, a specificity of 90%, a likelihood ratio of 5.0, and an area under receiver-operating characteristic curve of 71% were achieved for identification of women with MIAC leading to HCA. CONCLUSIONS: Our multi-stage study suggests cathelicidin as a candidate marker that should be considered for a panel of amniotic fluid proteins permitting identification

  19. Proteomics-Based Characterization of the Humoral Immune Response in Sporotrichosis: Toward Discovery of Potential Diagnostic and Vaccine Antigens

    Science.gov (United States)

    Rodrigues, Anderson Messias; Fernandes, Geisa Ferreira; Araujo, Leticia Mendes; Della Terra, Paula Portella; dos Santos, Priscila Oliveira; Pereira, Sandro Antonio; Schubach, Tânia Maria Pacheco; Burger, Eva; Lopes-Bezerra, Leila Maria; de Camargo, Zoilo Pires

    2015-01-01

    understanding of the coevolution of Sporothrix and its warm-blooded hosts. We propose that 3-carboxymuconate cyclase has potential for the serological diagnosis of sporotrichosis and as target for the development of an effective multi-species vaccine against sporotrichosis in animals and humans. PMID:26305691

  20. ATLAS Outreach Highlights

    CERN Document Server

    Cheatham, Susan; The ATLAS collaboration

    2016-01-01

    The ATLAS outreach team is very active, promoting particle physics to a broad range of audiences including physicists, general public, policy makers, students and teachers, and media. A selection of current outreach activities and new projects will be presented. Recent highlights include the new ATLAS public website and ATLAS Open Data, the very recent public release of 1 fb-1 of ATLAS data.

  1. ATLAS Story

    CERN Multimedia

    Nordberg, Markus

    2012-01-01

    This film produced in July 2012 explains how fundamental research connects to Society and what benefits collaborative way of working can and may generate in the future, using ATLAS Collaboration as a case study. The film is intellectually inspired by the book "Collisions and Collaboration" (OUP) by Max Boisot (ed.), see: collisionsandcollaboration.com. The film is directed by Andrew Millington (OMNI Communications)

  2. The Cognitive Atlas: Towards a knowledge foundation for cognitive neuroscience

    Directory of Open Access Journals (Sweden)

    Russell A Poldrack

    2011-09-01

    Full Text Available Cognitive neuroscience aims to map mental processes onto brain function, which begs the question of what ``mental processes'' exist and how they relate to the tasks that are used to manipulate and measure them. This topic has been addressed informally in prior work, but we propose that cumulative progress in cognitive neuroscience requires a more systematic approach to representing the mental entities that are being mapped to brain function and the tasks used to manipulate and measure mental processes. We describe a new open collaborative project that aims to provide a knowledge base for cognitive neuroscience, called the Cognitive Atlas (accessible online at http://www.cognitiveatlas.org, and outline how this project has the potential to drive novel discoveries about both mind and brain.

  3. ATLAS distributed computing: experience and evolution

    CERN Document Server

    Nairz, A; The ATLAS collaboration

    2014-01-01

    The ATLAS experiment has just concluded its first running period which commenced in 2010. After two years of remarkable performance from the LHC and ATLAS, the experiment has accumulated more than 25/fb of data. The total volume of beam and simulated data products exceeds 100~PB distributed across more than 150 computing centres around the world, managed by the experiment's distributed data management system. These sites have provided up to 150,000 computing cores to ATLAS's global production and analysis processing system, enabling a rich physics programme including the discovery of the Higgs-like boson in 2012. The wealth of accumulated experience in global data-intensive computing at this massive scale, and the considerably more challenging requirements of LHC computing from 2015 when the LHC resumes operation, are driving a comprehensive design and development cycle to prepare a revised computing model together with data processing and management systems able to meet the demands of higher trigger rates, e...

  4. ATLAS Distributed Computing: Experience and Evolution

    CERN Document Server

    Nairz, A; The ATLAS collaboration

    2013-01-01

    The ATLAS experiment has just concluded its first running period which commenced in 2010. After two years of remarkable performance from the LHC and ATLAS, the experiment has accumulated more than 25 fb-1 of data. The total volume of beam and simulated data products exceeds 100 PB distributed across more than 150 computing centers around the world, managed by the experiment's distributed data management system. These sites have provided up to 150,000 computing cores to ATLAS's global production and analysis processing system, enabling a rich physics program including the discovery of the Higgs-like boson in 2012. The wealth of accumulated experience in global data-intensive computing at this massive scale, and the considerably more challenging requirements of LHC computing from 2014 when the LHC resumes operation, are driving a comprehensive design and development cycle to prepare a revised computing model together with data processing and management systems able to meet the demands of higher trigger rates, e...

  5. Highlights from SUSY searches with ATLAS

    CERN Document Server

    Mitsou, V A

    2014-01-01

    Supersymmetry (SUSY) is one of the most relevant scenarios of new physics searched by the ATLAS experiment at the CERN Large Hadron Collider. In this write-up the principal search strategies employed by ATLAS are outlined and the most recent results for analyses targeting SUSY discovery are discussed. A wide range of signatures is covered motivated by various theoretical scenarios and topologies: strong production, third-generation fermions, long-lived particles and R-parity violation, among others. The results are based on up to ~5/fb of data recorded during 2010 - 2011 at sqrt(s) = 7 TeV centre-of-mass energy by the ATLAS experiment at the LHC.

  6. Per-residue energy decomposition pharmacophore model to enhance virtual screening in drug discovery: a study for identification of reverse transcriptase inhibitors as potential anti-HIV agents

    Directory of Open Access Journals (Sweden)

    Cele FN

    2016-04-01

    Full Text Available Favourite N Cele, Muthusamy Ramesh, Mahmoud ES Soliman Molecular Modelling and Drug Design Research Group, School of Health Sciences, University of KwaZulu-Natal, Durban, South Africa Abstract: A novel virtual screening approach is implemented herein, which is a further improvement of our previously published “target-bound pharmacophore modeling approach”. The generated pharmacophore library is based only on highly contributing amino acid residues, instead of arbitrary pharmacophores, which are most commonly used in the conventional approaches in literature. Highly contributing amino acid residues were distinguished based on free binding energy contributions obtained from calculation from molecular dynamic (MD simulations. To the best of our knowledge; this is the first attempt in the literature using such an approach; previous approaches have relied on the docking score to generate energy-based pharmacophore models. However, docking scores are reportedly unreliable. Thus, we present a model for a per-residue energy decomposition, constructed from MD simulation ensembles generating a more trustworthy pharmacophore model, which can be applied in drug discovery workflow. This work is aimed at introducing a more rational approach to the field of drug design, rather than comparing the validity of this approach against those previously reported. We recommend additional computational and experimental work to further validate this approach. This approach was used to screen for potential reverse transcriptase inhibitors using the pharmacophoric features of compound GSK952. The complex was subjected to docking, thereafter, MD simulation confirmed the stability of the system. Experimentally determined inhibitors with known HIV-reverse transcriptase inhibitory activity were used to validate the protocol. Two potential hits (ZINC46849657 and ZINC54359621 showed a significant potential with regard to free binding energy. Reported results obtained from

  7. Per-residue energy decomposition pharmacophore model to enhance virtual screening in drug discovery: a study for identification of reverse transcriptase inhibitors as potential anti-HIV agents.

    Science.gov (United States)

    Cele, Favourite N; Ramesh, Muthusamy; Soliman, Mahmoud Es

    2016-01-01

    A novel virtual screening approach is implemented herein, which is a further improvement of our previously published "target-bound pharmacophore modeling approach". The generated pharmacophore library is based only on highly contributing amino acid residues, instead of arbitrary pharmacophores, which are most commonly used in the conventional approaches in literature. Highly contributing amino acid residues were distinguished based on free binding energy contributions obtained from calculation from molecular dynamic (MD) simulations. To the best of our knowledge; this is the first attempt in the literature using such an approach; previous approaches have relied on the docking score to generate energy-based pharmacophore models. However, docking scores are reportedly unreliable. Thus, we present a model for a per-residue energy decomposition, constructed from MD simulation ensembles generating a more trustworthy pharmacophore model, which can be applied in drug discovery workflow. This work is aimed at introducing a more rational approach to the field of drug design, rather than comparing the validity of this approach against those previously reported. We recommend additional computational and experimental work to further validate this approach. This approach was used to screen for potential reverse transcriptase inhibitors using the pharmacophoric features of compound GSK952. The complex was subjected to docking, thereafter, MD simulation confirmed the stability of the system. Experimentally determined inhibitors with known HIV-reverse transcriptase inhibitory activity were used to validate the protocol. Two potential hits (ZINC46849657 and ZINC54359621) showed a significant potential with regard to free binding energy. Reported results obtained from this work confirm that this new approach is favorable in the future of the drug design industry. PMID:27114700

  8. The ATLAS Forward Physics Program

    CERN Document Server

    Pinfold, J L

    2009-01-01

    The ATLAS forward physics program is discussed in the light of the future detector upgrades under study. These developments will enhance the overall physics potential of the experiment. The physics topics presented include: luminosity determination using the LUCID and ALFA detectors; diffractive measurements that should be possible with early data; and, the AFP project which plans to deploy proton taggers at 220 and 420 m from the ATLAS IP. The AFP program includes such physics topics as hard diffraction; diffractive Higgs production,two photon physics; and, new physics in the forward region.

  9. ATLAS Detector Upgrade Prospects

    CERN Document Server

    Dobre, Monica; The ATLAS collaboration

    2016-01-01

    After the successful operation at the center-of-mass energies of 7 and 8 TeV in 2010 - 2012, the LHC is ramped up and successfully took data at the center-of-mass energies of 13 TeV in 2015. Meanwhile, plans are actively advancing for a series of upgrades of the accelerator, culminating roughly ten years from now in the high-luminosity LHC (HL-LHC) project, delivering of the order of five times the LHC nominal instantaneous luminosity along with luminosity leveling. The ultimate goal is to extend the dataset from about few hundred fb−1 expected for LHC running to 3000 fb−1 by around 2035 for ATLAS and CMS. The challenge of coping with the HL-LHC instantaneous and integrated luminosity, along with the associated radiation levels, requires further major changes to the ATLAS detector. The designs are developing rapidly for a new all-silicon tracker, significant upgrades of the calorimeter and muon systems, as well as improved triggers and data acquisition. ATLAS is also examining potential benefits of extens...

  10. Beyond Discovery

    DEFF Research Database (Denmark)

    Korsgaard, Steffen; Sassmannshausen, Sean Patrick

    2015-01-01

    as their central concepts and conceptualization of the entrepreneurial function. On this basis we discuss three central themes that cut across the four alternatives: process, uncertainty, and agency. These themes provide new foci for entrepreneurship research and can help to generate new research questions......In this chapter we explore four alternatives to the dominant discovery view of entrepreneurship; the development view, the construction view, the evolutionary view, and the Neo-Austrian view. We outline the main critique points of the discovery presented in these four alternatives, as well...

  11. Discovery of potential prognostic long non-coding RNA biomarkers for predicting the risk of tumor recurrence of breast cancer patients.

    Science.gov (United States)

    Zhou, Meng; Zhong, Lei; Xu, Wanying; Sun, Yifan; Zhang, Zhaoyue; Zhao, Hengqiang; Yang, Lei; Sun, Jie

    2016-01-01

    Deregulation of long non-coding RNAs (lncRNAs) expression has been proven to be involved in the development and progression of cancer. However, expression pattern and prognostic value of lncRNAs in breast cancer recurrence remain unclear. Here, we analyzed lncRNA expression profiles of breast cancer patients who did or did not develop recurrence by repurposing existing microarray datasets from the Gene Expression Omnibus database, and identified 12 differentially expressed lncRNAs that were closely associated with tumor recurrence of breast cancer patients. We constructed a lncRNA-focus molecular signature by the risk scoring method based on the expression levels of 12 relapse-related lncRNAs from the discovery cohort, which classified patients into high-risk and low-risk groups with significantly different recurrence-free survival (HR = 2.72, 95% confidence interval 2.07-3.57; p = 4.8e-13). The 12-lncRNA signature also represented similar prognostic value in two out of three independent validation cohorts. Furthermore, the prognostic power of the 12-lncRNA signature was independent of known clinical prognostic factors in at least two cohorts. Functional analysis suggested that the predicted relapse-related lncRNAs may be involved in known breast cancer-related biological processes and pathways. Our results highlighted the potential of lncRNAs as novel candidate biomarkers to identify breast cancer patients at high risk of tumor recurrence. PMID:27503456

  12. Optogenetics enlightens neuroscience drug discovery.

    Science.gov (United States)

    Song, Chenchen; Knöpfel, Thomas

    2016-02-01

    Optogenetics - the use of light and genetics to manipulate and monitor the activities of defined cell populations - has already had a transformative impact on basic neuroscience research. Now, the conceptual and methodological advances associated with optogenetic approaches are providing fresh momentum to neuroscience drug discovery, particularly in areas that are stalled on the concept of 'fixing the brain chemistry'. Optogenetics is beginning to translate and transit into drug discovery in several key domains, including target discovery, high-throughput screening and novel therapeutic approaches to disease states. Here, we discuss the exciting potential of optogenetic technologies to transform neuroscience drug discovery.

  13. Searches for Dark Matter with the ATLAS experiment

    CERN Document Server

    Lundberg, Olof; The ATLAS collaboration

    2015-01-01

    ATLAS is a multi-purpose detector aimed at fully exploiting the discovery potential of the proton-proton collisions at a center of mass energy of 8-14 TeV provided by CERN Large Hadron Collider. It is able to precisely identify and measure the properties of electrons, muons, photons, taus and hadronic jets. Thanks to an excellent hermeticity it is able to infer the production of neutrinos and dark matter particles from conservation of momentum using the missing energy observable. This talk will focus on the results of several dedicated searches for WIMP Dark Matter using the ATLAS detector. Among these searches are the so called "Mono-X" searches looking for signatures with large missing momentum recoiling against a gauge boson. We also present searches for decays of the Higgs boson into invisible states and searches for final states with missing transverse energy and third generation quarks. The results are interpreted in terms of Effective Field Theories as well as Simplified Models, and limits on nucleon-W...

  14. Potential for New Phenomena in Jet Events with the ATLAS Detector at $\\sqrt{s} = 13$ TeV

    CERN Document Server

    Dandoy, Jeffrey Rogers; The ATLAS collaboration

    2015-01-01

    With the start of Run II of the LHC, pp collisions at the center of mass energy of 13 TeV will open a great potential for observing physics beyond the Standard Model. The increase in center of mass energy greatly enhances the reach of searches in dijet and multijet events. Shortly after the start of data taking, the sensitivity to new resonant particles will surpass the limits set with the full Run I dataset. The ability to observe non-resonant deviations from the SM such as structure within quarks themselves is also greatly enhanced from the new operating conditions of the LHC. We will present the potential for searches for both resonant and non-resonant new physics in dijet and multijet events.

  15. X chromosome-linked CNVs in male infertility: discovery of overall duplication load and recurrent, patient-specific gains with potential clinical relevance.

    Directory of Open Access Journals (Sweden)

    Chiara Chianese

    Full Text Available Spermatogenesis is a highly complex process involving several thousand genes, only a minority of which have been studied in infertile men. In a previous study, we identified a number of Copy Number Variants (CNVs by high-resolution array-Comparative Genomic Hybridization (a-CGH analysis of the X chromosome, including 16 patient-specific X chromosome-linked gains. Of these, five gains (DUP1A, DUP5, DUP20, DUP26 and DUP40 were selected for further analysis to evaluate their clinical significance.The copy number state of the five selected loci was analyzed by quantitative-PCR on a total of 276 idiopathic infertile patients and 327 controls in a conventional case-control setting (199 subjects belonged to the previous a-CGH study. For one interesting locus (intersecting DUP1A additional 338 subjects were analyzed.All gains were confirmed as patient-specific and the difference in duplication load between patients and controls is significant (p = 1.65 × 10(-4. Two of the CNVs are private variants, whereas 3 are found recurrently in patients and none of the controls. These CNVs include, or are in close proximity to, genes with testis-specific expression. DUP1A, mapping to the PAR1, is found at the highest frequency (1.4% that was significantly different from controls (0% (p = 0.047 after Bonferroni correction. Two mechanisms are proposed by which DUP1A may cause spermatogenic failure: i by affecting the correct regulation of a gene with potential role in spermatogenesis; ii by disturbing recombination between PAR1 regions during meiosis. This study allowed the identification of novel spermatogenesis candidate genes linked to the 5 CNVs and the discovery of the first recurrent, X-linked gain with potential clinical relevance.

  16. ATLAS book wins the IPPY awards

    CERN Multimedia

    Abha Eli Phoboo

    2014-01-01

    Hunting the Higgs, published by Papadakis Publishers in collaboration with the ATLAS experiment has won the Bronze prize in the Science category of the Independent Publisher Book Awards (see here). The Award ceremony will be held on 28 May in New York on the eve of the BookExpo America (see here).   “Ours is a souvenir book that gives viewers a glimpse of the discovery of the Higgs boson and the collaborative effort behind it of thousands of scientists in ATLAS,” says Claudia Marcelloni, communications officer of the ATLAS Experiment, who worked on the book with freelance science writer Colin Barras. “The science is noble and the collaboration heartwarming, and the IPPY Award is a great way to celebrate the mind-blowing story of human achievement.” Hunting the Higgs is the inside story of the ATLAS experiment at the Large Hadron Collider. It tells the journey of the experiment, from before the detector was born to the announcement of the discovery of t...

  17. A silicon strip module for the ATLAS inner detector upgrade in the super LHC collider

    CERN Document Server

    Gonzalez-Sevilla, S; Parzefall, U; Clark, A; Ikegami, Y; Hara, K; Garcia, C; Jakobs, K; Dwuznik, M; Terada, S; Barbier, G; Koriki, T; Lacasta, C; Unno, Y; Anghinolfi, F; Cadoux, F; Garcia, S M I; Ferrere, D; La Marra, D; Pohl, M; Dabrowski, W; Kaplon, J

    2011-01-01

    The ATLAS detector is a general purpose experiment designed to fully exploit the discovery potential of the Large Hadron Collider (LHC) at a nominal luminosity of 10(34)cm(-2)s(-1). It is expected that after several years of successful data-taking, the LHC physics program will be extended by increasing the peak luminosity by one order of magnitude. For ATLAS, an upgrade scenario will imply the complete replacement of the Inner Detector (ID), since the current tracker will not provide the required performance due to cumulated radiation damage and a dramatic increase in the detector occupancy. In this paper, a proposal of a double-sided silicon micro-strip module for the short-strip region of the future ATLAS ID is presented. The expected thermal performance based upon detailed FEA simulations is discussed. First electrical results from a prototype version of the next generation readout front-end chips are also shown. (C) 2010 Elsevier B.V. All rights reserved.

  18. Commissioning of the Absolute Luminosity For ATLAS detector at the LHC

    CERN Document Server

    Jakobsen, Sune; Hansen, Peter; Hansen, Jørgen Beck

    The startup of the LHC (Large Hadron Collider) has initialized a new era in particle physics. The standard model of particle physics has for the last 40 years with tremendous success described all measurements with phenomenal precision. The experiments at the LHC are testing the standard model in a new energy regime. To normalize the measurements and understand the potential discoveries of the LHC experiments it is often crucial to know the interaction rate - the absolute luminosity. The ATLAS (A Toroidal LHC ApparatuS) detector will measure luminosity by numerous methods. But for most of the methods only the relative luminosity is measured with good precision. The absolute scale has to be provided from elsewhere. ATLAS is like the other LHC experiments mainly relying of absolute luminosity calibration from van der Meer scans (beam separation scans). To cross check and maybe even improve the precision; ATLAS has built a sub-detector to measure the flux of protons scattered under very small angles as this flux...

  19. Discovery of the Higgs boson, measurements of Higgs boson properties, and search for high mass beyond the Standard Model scalar particle in the diphoton final state with the ATLAS detector at the Large Hadron Collider

    CERN Document Server

    AUTHOR|(INSPIRE)INSPIRE-00336678

    With 4.8~$\\rm{fb}^{-1}$ of proton-proton collision data collected at $\\sqrt{s}=7~\\rm{TeV}$ in 2011, and 5.9~$\\rm{fb}^{-1}$ collected at $\\sqrt{s}=8~\\rm{TeV}$ in 2012 by the ATLAS detector at the Large Hadron Collider, an excess of 4.5 standard deviations from the background-only hypothesis is observed near 126.5~GeV in the diphoton invariant mass spectra. Along with the excesses observed in the $H \\rightarrow ZZ^{(*)}\\rightarrow \\ell\\ell\\ell\\ell$ and $H \\rightarrow WW^{(*)}\\rightarrow \\ell\

  20. ATLAS trigger for first physics and beyond

    CERN Document Server

    Fonseca-Martin, T

    2009-01-01

    ATLAS is a multi-purpose spectrometer built to perform precision measurements of Standard Model parameters and is aiming at discovery of Higgs particle, Super Symmetry and possible other physics channels beyond Standard Model. Operating at 14 TeV center of mass energy ATLAS will see 40 million events per second at nominal luminosity with about 25 overlapping interactions. Most of the events are inelastic proton-proton interactions with only few W, Z bosons or ttbar pairs produced each second, and expectations for Higgs or SUSY production cross-section are much smaller than that. ATLAS trigger has a difficult task to select one out of $10^5$ events online and to ensure that most physics channels of interests are preserved for analysis. In this talk we will review the design of ATLAS trigger system, the trigger menu prepared for initial LHC run as well as for high luminosity run. The expected trigger performance of the base-line ATLAS physics programs will be reviewed and first results from the commissioning pe...

  1. All 2006 ATLAS Tutorials online

    CERN Multimedia

    Steven Goldfarb,; Mitch McLachlan,; Homer A. Neal

    The University of Michigan has completed its full agenda of Web Lecture recording for ATLAS for 2006. The archives include all three ATLAS Week Plenary Sessions, as well as a large variety of tutorials. They are accessible at target="_top" this location. Viewing requires a standard web browser with RealPlayer plug-in (included in most browsers automatically) and works on any major platform. This is the first year our group has been asked to provide this complete service to the collaboration, so any and all feedback is welcome. We would especially like to know if you had any difficulties viewing the lectures, if you found the selection of material to be useful, and/or if you think there are any other specific events we ought to cover in 2007. Please send you comments to wlap@umich.edu. We look forward to bringing you a rich variety of new lectures in 2007, starting with the ATLAS Distributed Computing Tutorial on Feb 1, 2 in Edinburgh and concluding with the Higgs discovery talk (of course). Enjoy the Lec...

  2. Swiss atlas of geothermal resources; Geothermischer Ressourcenatlas der Schweiz. Erarbeitung und Bewertung des geothermischen Potentials der Schweiz

    Energy Technology Data Exchange (ETDEWEB)

    Signorelli, S.; Andenmatten Berthoud, N.; Kohl, T. [Geowatt AG, Zuerich (Switzerland)

    2004-07-01

    This final report presents a review of the results of work done on behalf of the Swiss Federal Office of Energy (SFOE) and the Swiss Geophysical Commission on research into the potential of geothermal energy in Switzerland. The geothermal productivity of the subsurface below the Swiss Plateau is separately assessed for individual geothermal compartments. The study presents geological, geothermal, and hydro-geological data-analyses in three dimensions, thus providing a basis for estimating possible geothermal production. The report also presents regional geological models that have been established for north-eastern Switzerland and the Basle region. The exploitable geothermal resources are defined and classified by temperature distribution and hydro-geological conditions. Figures are given on the heat available for heat-exploitation at various depths.

  3. Generation of ESTs in Vitis vinifera wine grape (Cabernet Sauvignon) and table grape (Muscat Hamburg) and discovery of new candidate genes with potential roles in berry development.

    Science.gov (United States)

    Peng, Fred Y; Reid, Karen E; Liao, Nancy; Schlosser, James; Lijavetzky, Diego; Holt, Robert; Martínez Zapater, José M; Jones, Steven; Marra, Marco; Bohlmann, Jörg; Lund, Steven T

    2007-11-01

    We report the generation and analysis of a total of 77,583 expressed sequence tags (ESTs) from two grapevine (Vitis vinifera L.) cultivars, Cabernet Sauvignon (wine grape) and Muscat Hamburg (table grape) with a focus on EST sequence quality and assembly optimization. The majority of the ESTs were derived from normalized cDNA libraries representing berry pericarp and seed developmental series, pooled non-berry tissues including root, flower, and leaf in Cabernet Sauvignon, and pooled tissues of berry, seed, and flower in Muscat Hamburg. EST and unigene sequence quality were determined by computational filtering coupled with small-scale contig reassembly, manual review, and BLAST analyses. EST assembly was optimized to better discriminate among closely related paralogs using two independent grape sequence sets, a previously published set of Vitis spp. gene families and our EST dataset derived from pooled leaf, flower, and root tissues of Cabernet Sauvignon. Sequence assembly within individual libraries indicated that those prepared from pooled tissues contributed the most to gene discovery. Annotations based upon searches against multiple databases including tomato and strawberry sequences helped to identify putative functions of ESTs and unigenes, particularly with respect to fleshy fruit development. Sequence comparison among the three wine grape libraries identified a number of genes preferentially expressed in the pericarp tissue, including transcription factors, receptor-like protein kinases, and hexose transporters. Gene ontology (GO) classification in the biological process aspect showed that GO categories corresponding to 'transport' and 'cell organization and biogenesis', which are associated with metabolite movement and cell wall structural changes during berry ripening, were higher in pericarp than in other tissues in the wine grape studied. The sequence data were used to characterize potential roles of new genes in berry development and composition. PMID

  4. Production of the Finnish Wind Atlas

    DEFF Research Database (Denmark)

    Tammelin, Bengt; Vihma, Timo; Atlaskin, Evgeny;

    2013-01-01

    The Finnish Wind Atlas was prepared applying the mesoscale model AROME with 2.5 km horizontal resolution and the diagnostic downscaling method Wind Atlas Analysis and Application Programme (WAsP) with 250 m resolution. The latter was applied for areas most favourable for wind power production: a 30......) the parameterization method for gust factor was extended to be applicable at higher altitudes; and (vii) the dissemination of the Wind Atlas was based on new technical solutions. The AROME results were calculated for the heights of 50, 75, 100, 125, 150, 200, 300 and 400 m, and the WAsP results for the heights of 50......, 75, 100, 125 and 150 m. In addition to the wind speed, the results included the values of the Weibull distribution parameters, the gust factor, wind power content and the potential power production, which was calculated for three turbine sizes. The Wind Atlas data are available for each grid point...

  5. Electroweak Physics with ATLAS

    OpenAIRE

    Akhundov, Arif

    2008-01-01

    The precision measurements of electroweak parameters of the Standard Model with the ATLAS detector at LHC are reviewed. An emphasis is put on the bridge connecting the ATLAS measurements with the SM analysis at LEP/SLC and the Tevatron.

  6. Recent ATLAS Articles on WLAP

    CERN Multimedia

    J. Herr

    As reported in the September 2004 ATLAS eNews, the Web Lecture Archive Project is a system for the archiving and publishing of multimedia presentations, using the Web as medium. We list here newly available WLAP items relating to ATLAS: Atlas Physics Workshop 6-11 June 2005 June 2005 ATLAS Week Plenary Session Click here to browse WLAP for all ATLAS lectures.

  7. Discovery Mondays

    CERN Document Server

    2003-01-01

    Many people don't realise quite how much is going on at CERN. Would you like to gain first-hand knowledge of CERN's scientific and technological activities and their many applications? Try out some experiments for yourself, or pick the brains of the people in charge? If so, then the «Lundis Découverte» or Discovery Mondays, will be right up your street. Starting on May 5th, on every first Monday of the month you will be introduced to a different facet of the Laboratory. CERN staff, non-scientists, and members of the general public, everyone is welcome. So tell your friends and neighbours and make sure you don't miss this opportunity to satisfy your curiosity and enjoy yourself at the same time. You won't have to listen to a lecture, as the idea is to have open exchange with the expert in question and for each subject to be illustrated with experiments and demonstrations. There's no need to book, as Microcosm, CERN's interactive museum, will be open non-stop from 7.30 p.m. to 9 p.m. On the first Discovery M...

  8. EnviroAtlas - Portland, OR - Atlas Area Boundary

    Data.gov (United States)

    U.S. Environmental Protection Agency — This EnviroAtlas dataset shows the boundary of the Portland, OR Atlas Area. It represents the outside edge of all the block groups included in the EnviroAtlas Area....

  9. Ayurvedic drug discovery.

    Science.gov (United States)

    Balachandran, Premalatha; Govindarajan, Rajgopal

    2007-12-01

    Ayurveda is a major traditional system of Indian medicine that is still being successfully used in many countries. Recapitulation and adaptation of the older science to modern drug discovery processes can bring renewed interest to the pharmaceutical world and offer unique therapeutic solutions for a wide range of human disorders. Eventhough time-tested evidences vouch immense therapeutic benefits for ayurvedic herbs and formulations, several important issues are required to be resolved for successful implementation of ayurvedic principles to present drug discovery methodologies. Additionally, clinical examination in the extent of efficacy, safety and drug interactions of newly developed ayurvedic drugs and formulations are required to be carefully evaluated. Ayurvedic experts suggest a reverse-pharmacology approach focusing on the potential targets for which ayurvedic herbs and herbal products could bring tremendous leads to ayurvedic drug discovery. Although several novel leads and drug molecules have already been discovered from ayurvedic medicinal herbs, further scientific explorations in this arena along with customization of present technologies to ayurvedic drug manufacturing principles would greatly facilitate a standardized ayurvedic drug discovery.

  10. ATLAS Recordings

    CERN Multimedia

    Jeremy Herr; Homer A. Neal; Mitch McLachlan

    The University of Michigan Web Archives for the 2006 ATLAS Week Plenary Sessions, as well as the first of 2007, are now online. In addition, there are a wide variety of Software and Physics Tutorial sessions, recorded over the past couple years, to chose from. All ATLAS-specific archives are accessible here.Viewing requires a standard web browser with RealPlayer plug-in (included in most browsers automatically) and works on any major platform. Lectures can be viewed directly over the web or downloaded locally.In addition, you will find access to a variety of general tutorials and events via the portal. Shaping Collaboration 2006The Michigan group is happy to announce a complete set of recordings from the Shaping Collaboration conference held last December at the CICG in Geneva.The event hosted a mix of Collaborative Tool experts and LHC Users, and featured presentations by the CERN Deputy Director General, Prof. Jos Engelen, the President of Internet2, and chief developers from VRVS/EVO, WLAP, and other tools...

  11. ATLAS and CMS Run-1 results on Higgs and Standard model physics and first 13 TeV measurements with ATLAS

    CERN Document Server

    Gaycken, Goetz; The ATLAS collaboration

    2015-01-01

    The wealth of data collected during the LHC Run-1 allowed many SM parameters to be measured and, most notably, lead to the discovery of the Higgs boson. This talk will summarise the most important ATLAS and CMS Run-1 results concerning the SM, including measurements of the properties of the discovered Higgs boson, assumed to be the predicted SM particle. The second part of the talk will focus on ATLAS, and present the improvements of the detector and its performance following the LS1 shutdown. The talk will finish with the first ATLAS Run-2 results at sqrt(s)=13TeV.

  12. ATLAS Distributed Computing Automation

    CERN Document Server

    Schovancova, J; The ATLAS collaboration; Borrego, C; Campana, S; Di Girolamo, A; Elmsheuser, J; Hejbal, J; Kouba, T; Legger, F; Magradze, E; Medrano Llamas, R; Negri, G; Rinaldi, L; Sciacca, G; Serfon, C; Van Der Ster, D C

    2012-01-01

    The ATLAS Experiment benefits from computing resources distributed worldwide at more than 100 WLCG sites. The ATLAS Grid sites provide over 100k CPU job slots, over 100 PB of storage space on disk or tape. Monitoring of status of such a complex infrastructure is essential. The ATLAS Grid infrastructure is monitored 24/7 by two teams of shifters distributed world-wide, by the ATLAS Distributed Computing experts, and by site administrators. In this paper we summarize automation efforts performed within the ATLAS Distributed Computing team in order to reduce manpower costs and improve the reliability of the system. Different aspects of the automation process are described: from the ATLAS Grid site topology provided by the ATLAS Grid Information System, via automatic site testing by the HammerCloud, to automatic exclusion from production or analysis activities.

  13. ATLAS distributed computing: experience and evolution

    Science.gov (United States)

    Nairz, A.; Atlas Collaboration

    2014-06-01

    The ATLAS experiment has just concluded its first running period which commenced in 2010. After two years of remarkable performance from the LHC and ATLAS, the experiment has accumulated more than 25 fb-1 of data. The total volume of beam and simulated data products exceeds 100 PB distributed across more than 150 computing centres around the world, managed by the experiment's distributed data management system. These sites have provided up to 150,000 computing cores to ATLAS's global production and analysis processing system, enabling a rich physics programme including the discovery of the Higgs-like boson in 2012. The wealth of accumulated experience in global data-intensive computing at this massive scale, and the considerably more challenging requirements of LHC computing from 2015 when the LHC resumes operation, are driving a comprehensive design and development cycle to prepare a revised computing model together with data processing and management systems able to meet the demands of higher trigger rates, energies and event complexities. An essential requirement will be the efficient utilisation of current and future processor technologies as well as a broad range of computing platforms, including supercomputing and cloud resources. We will report on experience gained thus far and our progress in preparing ATLAS computing for the future.

  14. The Education and Outreach Program of ATLAS

    CERN Multimedia

    Barnett, M.

    2006-01-01

    The ATLAS Education and Outreach (E&O) program began in 1997, but the advent of LHC has placed a new urgency in our efforts. Even a year away, we can feel the approaching impact of starting an experiment that could make revolutionary discoveries. The public and teachers are beginning to turn their attention our way, and the newsmedia are showing growing interest in ATLAS. When datataking begins, the interest will peak, and the demands on us are likely to be substantial. The collaboration is responding to this challenge in a number of ways. ATLAS management has begun consultation with experts. The official budget for the E&O group has been growing as have the contributions of many ATLAS institutions. The number of collaboration members joining these efforts has grown, and their time and effort is increasing. We are in ongoing consultation with the CERN Public Affairs Office, as well as the other LHC experiments and the European Particle Physics Outreach Group. The E&O group has expanded the scope...

  15. Sharing ATLAS data and research with young students

    CERN Document Server

    Pedersen, Maiken; The ATLAS collaboration; Bugge, Magnar Kopangen

    2015-01-01

    In recent years the International Masterclasses (IMC) featured the use of real experimental data as produced by the Large Hadron Collider (LHC) and collected by the detectors. We present ATLAS-based educational material using these data allowing high-school students to learn about properties of known particles and search for new phenomena. The ambition to bring to the “classrooms” important LHC discoveries is realised using the recent discovery of the Higgs boson. Approximately 10% of the ATLAS discovery data are made available for students to search for the Higgs boson: 2 fb−1 at 8 TeV for the Z path, and 1 fb−1 at 7 TeV for the W path, in the 2014 version of IMC. The Higgs study samples constitute one third of the total sample including Z, W and other low mass resonances. The educational material is tuned and expanded to follow LHC “heartbeats”.

  16. ATLAS Muon Trigger

    CERN Document Server

    Woudstra, MJ; The ATLAS collaboration

    2013-01-01

    CERN’s Large Hadron Collider (LHC) is the highest energy proton-proton collider, providing also the highest instantaneous luminosity as a hadron collider. Bunch crossings occurred every 50 ns in 2012 runs. Amongst of which the online event selection system should reduce the event recording rate down to a few 100 Hz, while events are in a harsh condition with many overlapping proton-proton collisions occurring in a same bunch crossing. Muons often provide an important and clear signature of physics processes that are searched for, for instance as in the discovery of Higgs particle in year 2012. The ATLAS experiment deploys a three-levels processing scheme at online. The level-1 muon trigger system gets its input from fast muon trigger detectors. Fast sector logic boards select muon candidates, which are passed via an interface board to the central trigger processor and then to the High Level Trigger (HLT). The muon HLT is purely software based and encompasses a level-2 (L2) trigger followed by an event filte...

  17. Virtual Visit to the ATLAS Control Room by William Floyd High School, New York

    CERN Multimedia

    ATLAS Experiment

    2012-01-01

    This ATLAS Virtual Visit features high school students from Mrs. Brazzelli's and Mrs. Meyer's Physics classes of William Floyd High School in Mastic Beach, NY. This experience will further student involvement in STEM disciplines. Students will be introduced to the Standard Model of particles, the ATLAS Experiment, and the Large Hadron Collider. Students will also have the opportunity to analyze and compare data from the ATLAS experiment and summarize the fundamental facts around the Higgs boson discovery. At the end of this activity students will interact with scientists by asking questions about the experiment. William Floyd High School is also involved in the International Physics Masterclass organized by the European Particle Physics Outreach Group. http://atlas-live-virtual-visit.web.cern.ch/atlas-live-virtual-visit/2012/WilliamFloyd-NY-2012.html

  18. Search for the Higgs boson in fermionic channels using the ATLAS detector

    Directory of Open Access Journals (Sweden)

    Hageböck Stephan

    2015-01-01

    Full Text Available Since the discovery of the Higgs boson by the ATLAS and CMS experiments at the LHC, the emphasis has shifted towards measurements of its properties. Of particular importance is the direct observation of the coupling of the Higgs boson to fermions. A review of ATLAS results in the search for the Higgs boson in tau, muon and b-quark pairs is presented.

  19. Consolidation of Cloud Computing in ATLAS

    CERN Document Server

    Taylor, Ryan P.; The ATLAS collaboration; Di Girolamo, Alessandro; Hover, John

    2016-01-01

    Throughout the first year of LHC Run 2, ATLAS Cloud Computing has undergone a period of consolidation, characterized by building upon previously established systems, with the aim of reducing operational effort, improving robustness, and reaching higher scale. This paper describes the current state of ATLAS Cloud Computing. Cloud activities are converging on a common contextualization approach for virtual machines, and cloud resources are sharing monitoring and service discovery components. We describe the integration of Vac resources, streamlined usage of the High Level Trigger cloud for simulation and reconstruction, extreme scaling on Amazon EC2, and procurement of commercial cloud capacity in Europe. Building on the previously established monitoring infrastructure, we have deployed a real-time monitoring and alerting platform which coalesces data from multiple sources, provides flexible visualization via customizable dashboards, and issues alerts and carries out corrective actions in response to problems. ...

  20. Performance of radiation-hard HV/HR CMOS sensors for the ATLAS inner detector upgrades

    Science.gov (United States)

    Liu, J.; Barbero, M.; Bilbao De Mendizabal, J.; Breugnon, P.; Godiot-Basolo, S.; Pangaud, P.; Rozanov, A.

    2016-03-01

    A major upgrade (Phase II Upgrade) to the Large Hadron Collider (LHC), scheduled for 2022, will be brought to the machine so as to extend its discovery potential. The upgraded LHC, called High-Luminosity LHC (HL-LHC), will run with a nominal leveled instantaneous luminosity of 5×1034 cm-2s-1, more than twice the expected luminosity. This unprecedented luminosity will result in higher occupancy and background radiations, which will request the design of a new Inner Tracker (ITk) which should have higher granularity, reduced material budget and improved radiation tolerance. A new pixel sensor concept based on High Voltage and High Resistivity CMOS (HV/HR CMOS) technology targeting the ATLAS inner detector upgrade is under exploration. With respect to the traditional hybrid pixel detector, the HV/HR CMOS sensor can potentially offer lower material budget, reduced pixel pitch and lower cost. Several prototypes have been designed and characterized within the ATLAS upgrade R&D effort, to investigate the detection and radiation hardness performance of various commercial technologies. An overview of the HV/HR CMOS sensor operation principle is described in this paper. The characterizations of three prototypes with X-ray, proton and neutron irradiation are also given.

  1. HV/HR-CMOS sensors for the ATLAS upgrade—concepts and test chip results

    Science.gov (United States)

    Liu, J.; Backhaus, M.; Barbero, M.; Bates, R.; Blue, A.; Bompard, F.; Breugnon, P.; Buttar, C.; Capeans, M.; Clemens, J. C.; Feigl, S.; Ferrere, D.; Fougeron, D.; Garcia-Sciveres, M.; George, M.; Godiot-Basolo, S.; Gonella, L.; Gonzalez-Sevilla, S.; Große-Knetter, J.; Hemperek, T.; Hügging, F.; Hynds, D.; Iacobucci, G.; Kreidl, C.; Krüger, H.; La Rosa, A.; Miucci, A.; Muenstermann, D.; Nessi, M.; Obermann, T.; Pangaud, P.; Perić, I.; Pernegger, H.; Quadt, A.; Rieger, J.; Ristic, B.; Rozanov, A.; Weingarten, J.; Wermes, N.

    2015-03-01

    In order to extend its discovery potential, the Large Hadron Collider (LHC) will have a major upgrade (Phase II Upgrade) scheduled for 2022. The LHC after the upgrade, called High-Luminosity LHC (HL-LHC), will operate at a nominal leveled instantaneous luminosity of 5× 1034 cm-2 s-1, more than twice the expected Phase I . The new Inner Tracker needs to cope with this extremely high luminosity. Therefore it requires higher granularity, reduced material budget and increased radiation hardness of all components. A new pixel detector based on High Voltage CMOS (HVCMOS) technology targeting the upgraded ATLAS pixel detector is under study. The main advantages of the HVCMOS technology are its potential for low material budget, use of possible cheaper interconnection technologies, reduced pixel size and lower cost with respect to traditional hybrid pixel detector. Several first prototypes were produced and characterized within ATLAS upgrade R&D effort, to explore the performance and radiation hardness of this technology. In this paper, an overview of the HVCMOS sensor concepts is given. Laboratory tests and irradiation tests of two technologies, HVCMOS AMS and HVCMOS GF, are also given.

  2. HV/HR-CMOS sensors for the ATLAS upgrade—concepts and test chip results

    International Nuclear Information System (INIS)

    In order to extend its discovery potential, the Large Hadron Collider (LHC) will have a major upgrade (Phase II Upgrade) scheduled for 2022. The LHC after the upgrade, called High-Luminosity LHC (HL-LHC), will operate at a nominal leveled instantaneous luminosity of 5× 1034 cm−2 s−1, more than twice the expected Phase I . The new Inner Tracker needs to cope with this extremely high luminosity. Therefore it requires higher granularity, reduced material budget and increased radiation hardness of all components. A new pixel detector based on High Voltage CMOS (HVCMOS) technology targeting the upgraded ATLAS pixel detector is under study. The main advantages of the HVCMOS technology are its potential for low material budget, use of possible cheaper interconnection technologies, reduced pixel size and lower cost with respect to traditional hybrid pixel detector. Several first prototypes were produced and characterized within ATLAS upgrade R and D effort, to explore the performance and radiation hardness of this technology. In this paper, an overview of the HVCMOS sensor concepts is given. Laboratory tests and irradiation tests of two technologies, HVCMOS AMS and HVCMOS GF, are also given

  3. Performance of radiation-hard HV/HR CMOS sensors for the ATLAS inner detector upgrades

    International Nuclear Information System (INIS)

    A major upgrade (Phase II Upgrade) to the Large Hadron Collider (LHC), scheduled for 2022, will be brought to the machine so as to extend its discovery potential. The upgraded LHC, called High-Luminosity LHC (HL-LHC), will run with a nominal leveled instantaneous luminosity of 5×1034 cm−2s−1, more than twice the expected luminosity. This unprecedented luminosity will result in higher occupancy and background radiations, which will request the design of a new Inner Tracker (ITk) which should have higher granularity, reduced material budget and improved radiation tolerance. A new pixel sensor concept based on High Voltage and High Resistivity CMOS (HV/HR CMOS) technology targeting the ATLAS inner detector upgrade is under exploration. With respect to the traditional hybrid pixel detector, the HV/HR CMOS sensor can potentially offer lower material budget, reduced pixel pitch and lower cost. Several prototypes have been designed and characterized within the ATLAS upgrade R and D effort, to investigate the detection and radiation hardness performance of various commercial technologies. An overview of the HV/HR CMOS sensor operation principle is described in this paper. The characterizations of three prototypes with X-ray, proton and neutron irradiation are also given

  4. The Irish Wind Atlas

    Energy Technology Data Exchange (ETDEWEB)

    Watson, R. [Univ. College Dublin, Dept. of Electronic and Electrical Engineering, Dublin (Ireland); Landberg, L. [Risoe National Lab., Meteorology and Wind Energy Dept., Roskilde (Denmark)

    1999-03-01

    The development work on the Irish Wind Atlas is nearing completion. The Irish Wind Atlas is an updated improved version of the Irish section of the European Wind Atlas. A map of the irish wind resource based on a WA{sup s}P analysis of the measured data and station description of 27 measuring stations is presented. The results of previously presented WA{sup s}P/KAMM runs show good agreement with these results. (au)

  5. The Higgs boson discovery at the Large Hadron Collider

    CERN Document Server

    Wolf, Roger

    2015-01-01

    This book provides a comprehensive overview of the field of Higgs boson physics. It offers the first in-depth review of the complete results in connection with the discovery of the Higgs boson at CERN’s Large Hadron Collider and based on the full dataset for the years 2011 to 2012. The fundamental concepts and principles of Higgs physics are introduced and the important searches prior to the advent of the Large Hadron Collider are briefly summarized. Lastly, the discovery and first mensuration of the observed particle in the course of the CMS experiment are discussed in detail and compared to the results obtained in the ATLAS experiment.

  6. Recent ATLAS Articles on WLAP

    CERN Multimedia

    Goldfarb, S

    2005-01-01

    As reported in the September 2004 ATLAS eNews, the Web Lecture Archive Project is a system for the archiving and publishing of multimedia presentations, using the Web as medium. We list here newly available WLAP items relating to ATLAS: Atlas Software Week Plenary 6-10 December 2004 North American ATLAS Physics Workshop (Tucson) 20-21 December 2004 (17 talks) Physics Analysis Tools Tutorial (Tucson) 19 December 2004 Full Chain Tutorial 21 September 2004 ATLAS Plenary Sessions, 17-18 February 2005 (17 talks) Coming soon: ATLAS Tutorial on Electroweak Physics, 14 Feb. 2005 Software Workshop, 21-22 February 2005 Click here to browse WLAP for all ATLAS lectures.

  7. Production and Quality Control of Micromegas Anode PCBs for the ATLAS NSW Upgrade

    CERN Document Server

    Kuger, Fabian; The ATLAS collaboration

    2016-01-01

    To exploit the full discovery potential of the Large Hadron Collider an upgrade towards high luminosity (HL-LHC) is scheduled until 2024-25. In parallel to the accelerator the experiments have to adopt to the expected higher particle rates and detector occupancy. Within the next long shutdown in 2019-20 the innermost end-cap regions of the ATLAS Muon spectrometer will be replaced by the New Small Wheels (NSW) including Micromegas detector modules of several m$^2$ size. The Micromegas Readout Anode boards, representing the core components of the detector, are manufactured in industry, making the NSW Micromegas the first Micro Pattern Gaseous Detector (MPGD) for a major LHC experiment with a crucial industrial contribution. Production of the up to 2.2\\,m long boards is a serious challenge on industrialization technology and quality control methods.

  8. Searches for Supersymmetric Particles with the ATLAS Detector Using Boosted Decay Tree Topologies

    CERN Document Server

    AUTHOR|(INSPIRE)INSPIRE-00399438; De, Kaushik; Hadavand, Haleh; Musielak, Zdzislaw; White, Andrew

    The existence of a scalar Higgs particle poses a challenge to the Standard Model through an unnatural hierarchy problem with quadratic divergence. A supersymmetric framework, proposing heavy partners to every Standard Model particle, can solve this problem by introducing new loop diagrams that involve a new fermion-boson symmetry. The LHC has the potential to probe the energy scale necessary for creation of these particles and the ATLAS experiment is poised for discovery. The detected particles are studied by reconstructing the detected events in boosted frames that approximate each decay frame of the interaction with pairs of heavy, invisible particles. This Razor method was used in the analysis of data from 2011 and 2012 and then generalized to the Recursive Jigsaw method in 2015.

  9. Discovery of novel enzymes with industrial potential from a cold and alkaline environment by a combination of functional metagenomics and culturing

    DEFF Research Database (Denmark)

    Vester, Jan Kjølhede; Glaring, Mikkel Andreas; Stougaard, Peter

    2014-01-01

    to these conditions. Since only a small fraction of the total microbial diversity can be cultured in the laboratory, a combined approach involving functional screening of a strain collection and a metagenomic library was undertaken for discovery of novel enzymes from the ikaite columns.Results: A strain collection......-amylases and β-galactosidases were characterized in more detail with respect to temperature and pH profiles and one of the β-galactosidases, BGalI17E2, was able to hydrolyze lactose at 5°C. A metagenome sequence of the expression library indicated that the majority of enzymatic activities were not detected....../or alkaline-active enzymes of industrial relevance were identified in the culture based approach and the majority of the enzyme-producing isolates were closely related to previously characterized strains. The function-based metagenomic approach, on the other hand, identified several enzymes (β...

  10. Renewable energy atlas of the United States.

    Energy Technology Data Exchange (ETDEWEB)

    Kuiper, J.A.; Hlava, K.Greenwood, H.; Carr, A. (Environmental Science Division)

    2012-05-01

    The Renewable Energy Atlas (Atlas) of the United States is a compilation of geospatial data focused on renewable energy resources, federal land ownership, and base map reference information. It is designed for the U.S. Department of Agriculture Forest Service (USFS) and other federal land management agencies to evaluate existing and proposed renewable energy projects. Much of the content of the Atlas was compiled at Argonne National Laboratory (Argonne) to support recent and current energy-related Environmental Impact Statements and studies, including the following projects: (1) West-wide Energy Corridor Programmatic Environmental Impact Statement (PEIS) (BLM 2008); (2) Draft PEIS for Solar Energy Development in Six Southwestern States (DOE/BLM 2010); (3) Supplement to the Draft PEIS for Solar Energy Development in Six Southwestern States (DOE/BLM 2011); (4) Upper Great Plains Wind Energy PEIS (WAPA/USFWS 2012, in progress); and (5) Energy Transport Corridors: The Potential Role of Federal Lands in States Identified by the Energy Policy Act of 2005, Section 368(b) (in progress). This report explains how to add the Atlas to your computer and install the associated software; describes each of the components of the Atlas; lists the Geographic Information System (GIS) database content and sources; and provides a brief introduction to the major renewable energy technologies.

  11. Book review: World atlas of mangroves

    Science.gov (United States)

    Krauss, Ken W.; Friess, Daniel A.

    2011-01-01

    Nearly 14 years have passed since the first atlas, World Mangrove Atlas (Spalding et al. 1997), was published. While scientists throughout the world have shared their insights about these ecosystems from a handful of “classic” mangrove ecology treatises, no book since has provided the same platform for understanding the global importance of mangroves by simply defining their distribution. The vast majority of mangrove research programs are modest in size and limited in funding. Nonetheless, much knowledge has been gained since the last atlas, including a potential role for mangroves in storm protection, proactive adjustment of soil surface elevation with sea-level rise, coastal water conservation, economic importance locally, etc. Furthermore, by documenting what can be lost, this book allows the reader to imagine what a world without mangroves might look like (see also Science 317, 41–42). If the first atlas established a mere image of an important wetland community type in peril, then this current edition paints a picture rivaling what an artist may have envisioned. The World Atlas of Mangroves is a comprehensive, well-written, ambitious, and artistic work that we can certainly recommend, and that should be part of any serious wetland library.

  12. Insect-Specific Flaviviruses: A Systematic Review of Their Discovery, Host Range, Mode of Transmission, Superinfection Exclusion Potential and Genomic Organization

    Directory of Open Access Journals (Sweden)

    Bradley J. Blitvich

    2015-04-01

    Full Text Available There has been a dramatic increase in the number of insect-specific flaviviruses (ISFs discovered in the last decade. Historically, these viruses have generated limited interest due to their inability to infect vertebrate cells. This viewpoint has changed in recent years because some ISFs have been shown to enhance or suppress the replication of medically important flaviviruses in co-infected mosquito cells. Additionally, comparative studies between ISFs and medically important flaviviruses can provide a unique perspective as to why some flaviviruses possess the ability to infect and cause devastating disease in humans while others do not. ISFs have been isolated exclusively from mosquitoes in nature but the detection of ISF-like sequences in sandflies and chironomids indicates that they may also infect other dipterans. ISFs can be divided into two distinct phylogenetic groups. The first group currently consists of approximately 12 viruses and includes cell fusing agent virus, Kamiti River virus and Culex flavivirus. These viruses are phylogenetically distinct from all other known flaviviruses. The second group, which is apparently not monophyletic, currently consists of nine viruses and includes Chaoyang virus, Nounané virus and Lammi virus. These viruses phylogenetically affiliate with mosquito/vertebrate flaviviruses despite their apparent insect-restricted phenotype. This article provides a review of the discovery, host range, mode of transmission, superinfection exclusion ability and genomic organization of ISFs. This article also attempts to clarify the ISF nomenclature because some of these viruses have been assigned more than one name due to their simultaneous discoveries by independent research groups.

  13. ATLAS Virtual Visit Albuquerque-05-06-2014

    CERN Multimedia

    2014-01-01

    Projecting Particles is a two-day, hands-on workshop for middle and high-school students from Albuquerque, New Mexico focused on exploring and experiencing the theoretical concepts of particle physics through light, space, form and movement. Conceived by STEMArts founder and interdisciplinary artist, Agnes Chavez, the workshop is a collaborative event presented by the National Hispanic Cultural Center and 516 ARTS for Digital Latin America. It is supported in part by Los Alamos National Laboratory and led in collaboration with Vienna based artist and Tagtool app developer, Markus Dorninger. Students will participate in the Atlas Virtual Tour to learn about cutting-edge discoveries in particle physics and their theoretical implications, such as supersymmetry and extra dimensions. - See more at: http://atlas-live-virtual-visit.web.cern.ch/atlas-live-virtual-visit/2014/Albuquerque-2014.html#sthash.DNv2nbuH.dpuf

  14. ATLAS Virtual Visit IceCube-02-10-2014

    CERN Document Server

    2014-01-01

    Building on last year’s success, high-school students and teachers in five countries will have the unique opportunity to interact live with researchers at the ATLAS and CMS experiments at CERN and researchers at the IceCube Neutrino Observatory in Antarctica. This virtual visit is the second event in the series, “Bringing Frontier Science to Schools”, that aims to connect the two laboratories, supported by the Open Discovery Space (ODS) project. ODS brings millions of educational resources directly into school classrooms, and empowers teachers to build their schools’ digital libraries, join lively communities of peers to share best practices, and connect their schools virtually with the world’s best research centres, museums and libraries. - See more at: http://atlas-live-virtual-visit.web.cern.ch/atlas-live-virtual-visit/2014/IceCube-2014.html#sthash.l523hihH.dpuf

  15. Study of ATLAS TRT performance with GRID and supercomputers.

    CERN Document Server

    Krasnopevtsev, Dimitriy; The ATLAS collaboration; Mashinistov, Ruslan; Belyaev, Nikita; Ryabinkin, Evgeny

    2015-01-01

    After the early success in discovering a new particle consistent with the long awaited Higgs boson, Large Hadron Collider experiments are ready for the precision measurements and further discoveries that will be made possible by much higher LHC collision rates from spring 2015. A proper understanding of the detectors performance at high occupancy conditions is important for many on-going physics analyses. The ATLAS Transition Radiation Tracker (TRT) is one of these detectors. TRT is a large straw tube tracking system that is the outermost of the three subsystems of the ATLAS Inner Detector (ID). TRT contributes significantly to the resolution for high-pT tracks in the ID providing excellent particle identification capabilities and electron-pion separation. ATLAS experiment is using Worldwide LHC Computing Grid. WLCG is a global collaboration of computer centers and provides seamless access to computing resources which include data storage capacity, processing power, sensors, visualisation tools and more. WLCG...

  16. Study of ATLAS TRT performance with GRID and supercomputers.

    CERN Document Server

    Krasnopevtsev, Dimitriy; The ATLAS collaboration; Belyaev, Nikita; Mashinistov, Ruslan; Ryabinkin, Evgeny

    2015-01-01

    After the early success in discovering a new particle consistent with the long awaited Higgs boson, Large Hadron Collider experiments are ready for the precision measurements and further discoveries that will be made possible by much higher LHC collision rates from spring 2015. A proper understanding of the detectors performance at highoccupancy conditions is important for many on-going physics analyses. The ATLAS Transition Radiation Tracker (TRT) is one of these detectors. TRT is a large straw tube tracking system that is the outermost of the three subsystems of the ATLAS Inner Detector (ID). TRT contributes significantly to the resolution for high-pT tracks in the ID providing excellent particle identification capabilities and electron-pion separation. ATLAS experiment is using Worldwide LHC Computing Grid. WLCG is a global collaboration of computer centers and provides seamless access to computing resources which include data storage capacity, processing power, sensors, visualization tools and more. WLCG ...

  17. Determination of the Higgs boson spin at ATLAS

    CERN Document Server

    Sanchez Pineda, A; The ATLAS collaboration

    2013-01-01

    In 2012 ATLAS and CMS collaborations announced the discovery of a new resonance in the search for the Standard Model (SM) Higgs boson. The next step is the experimental determination of its properties in order to understand if it’s the SM Higgs Boson or “someone” beyond. This presentation will resume the state of the art of the ATLAS studies of the spin/parity (JP) quantum numbers of the new boson, due to its production and decay nature, is a neutral boson. To distinguishing between different hypotheses, including that from the Standard Model, ATLAS relies on discriminant observables chosen to be sensitive to the spin and parity of the signal for each channel considered, using data recorded in 2011 and 2012.

  18. ATLAS Virtual Visit Seattle-10-09-2014

    CERN Multimedia

    2014-01-01

    This ATLAS Virtual Visit is part of the Discovery Seminar Activities organized by Prof. Shih-Chieh Hsu at the University of Washington. It features students from Early Fall Start LHC Physics classes for incoming freshman in 2014 at the University of Washington in Seattle. Students can interact with scientists at CERN by asking questions about physics, experiments, and the state-of-the-art technology of radiation detection. This experience will stimulate their curiosity about science by exposing them to some of the inside stories of the largest and the most complicated particle detector of the 21st century. - See more at: http://atlas-live-virtual-visit.web.cern.ch/atlas-live-virtual-visit/2014/Seattle-2014.html#sthash.5yfqV91S.dpuf

  19. ATLAS Future Plans: Upgrade and the Physics with High Luminosity

    Directory of Open Access Journals (Sweden)

    Rajagopalan S.

    2013-05-01

    Full Text Available The ATLAS experiment is planning a series of detector upgrades to cope with the planned increases in instantaneous luminosity and multiple interactions per crossing to maintain its physics capabilities. During the coming decade, the Large Hadron Collider will collide protons on protons at a center of mass energy up to 14 TeV with luminosities steadily increasing in a phased approach to over 5 × 1034 cm−2s−1. The resulting large data sets will significantly enhance the physics reach of the ATLAS detector building on the recent discovery of the Higgs-like boson. The planned detector upgrades being designed to cope with the increasing luminosity and its impact on the ATLAS physics program will be discussed.

  20. Search for Lepton Flavor Violation with ATLAS

    CERN Document Server

    Blocker, Craig; The ATLAS collaboration

    2016-01-01

    Searches for Lepton Flavor Violation (LFV) are performed with 8- and 13-TeV data from the ATLAS detector at the LHC. Processes considered include LFV decays of Standard model particles (Z and H), LFV decays of potential new particles (Z' and sneutrino), RPV SUSY, heavy Marjorana neutrinos, and Quantum Black Holes.

  1. ATLAS Jet and Missing ET Reconstruction, Calibration & Performance

    CERN Document Server

    DeMarco, David; The ATLAS collaboration

    2016-01-01

    The performance of the reconstruction and calibration of the jet energy scale and missing transverse energy scale with the ATLAS detector at the LHC is a key component to realize the ATLAS full physics potential, both in the searches for new physics and in precision measurements. New algorithms used for the reconstruction and calibration of jets and missing energy with the ATLAS detector during LHC run 2 are presented. Measurements of the performance and uncertainties are derived from data. The results from the 2015 pp collision data set at sqrt(s)=13 TeV are reported.

  2. Searches for BSM Higgs Bosons with ATLAS

    CERN Document Server

    Navarro, Gabriela; The ATLAS collaboration

    2015-01-01

    The discovery of a Higgs-like boson with a mass of about 125GeV has prompted the question of whether or not this particle is part of a much larger and more complex Higgs sector than that envisioned in the Standard Model. In this talk, the current results from the ATLAS Experiment regarding Beyond-the-Standard Model (BSM) Higgs hypothesis tests are outlined. Searches for additional Higgs bosons are presented and interpreted in well-motivated BSM Higgs frameworks, such as two-Higgs-doublet Models and the Minimal Supersymmetric Standard Model.

  3. ATLAS brochure (Norwegian version)

    CERN Multimedia

    Lefevre, C

    2009-01-01

    ATLAS is the largest detector at the LHC, the most powerful particle accelerator in the world. ATLAS is a multi-purpose detector, designed to throw light on fundamental questions such as the origin of mass and the nature of the Universe's dark matter. Français

  4. The ATLAS tile calorimeter

    CERN Multimedia

    Maximilien Brice

    2003-01-01

    Louis Rose-Dulcina, a technician from the ATLAS collaboration, works on the ATLAS tile calorimeter. Special manufacturing techniques were developed to mass produce the thousands of elements in this detector. Tile detectors are made in a sandwich-like structure where these scintillator tiles are placed between metal sheets.

  5. The ATLAS pixel detector

    OpenAIRE

    Cristinziani, M.

    2007-01-01

    After a ten years planning and construction phase, the ATLAS pixel detector is nearing its completion and is scheduled to be integrated into the ATLAS detector to take data with the first LHC collisions in 2007. An overview of the construction is presented with particular emphasis on some of the major and most recent problems encountered and solved.

  6. ATLAS TV PROJECT

    CERN Multimedia

    2005-01-01

    La Givrine near St Cergue Cross Country Skiing and Fondue at Basse Ruche with M Nordberg, P Jenni, M Nessi, F Gianotti and Co. ATLAS Management Fondu dinner, reviewing state of play of the experiment Many fun scenes from cross country skiing and after 41 minutes of the film starts the fondue dinner in a nice chalet with many persons working for ATLAS experiment

  7. ATLAS TV PROJECT

    CERN Multimedia

    2005-01-01

    Budker Nuclear Physics Institute, Novosibirsk Sequence 1 Shots of aircraft factory where machining for ATLAS is done Shots of aircraft Work on components for ATLAS big wheel Discussions between Tikhonov and Nordberg in workshop Sequence 2 Shots of downtown Novosibirsk, including little church which is mid-point of Russian Federation Sequence 3 Interview of Yuri Tikhonov by Andrew Millington

  8. ATLAS Colouring Book

    CERN Multimedia

    Anthony, Katarina

    2016-01-01

    The ATLAS Experiment Colouring Book is a free-to-download educational book, ideal for kids aged 5-9. It aims to introduce children to the field of High-Energy Physics, as well as the work being carried out by the ATLAS Collaboration.

  9. ATLAS people can run!

    CERN Multimedia

    Claudia Marcelloni de Oliveira; Pauline Gagnon

    It must be all the training we are getting every day, running around trying to get everything ready for the start of the LHC next year. This year, the ATLAS runners were in fine form and came in force. Nine ATLAS teams signed up for the 37th Annual CERN Relay Race with six runners per team. Under a blasting sun on Wednesday 23rd May 2007, each team covered the distances of 1000m, 800m, 800m, 500m, 500m and 300m taking the runners around the whole Meyrin site, hills included. A small reception took place in the ATLAS secretariat a week later to award the ATLAS Cup to the best ATLAS team. For the details on this complex calculation which takes into account the age of each runner, their gender and the color of their shoes, see the July 2006 issue of ATLAS e-news. The ATLAS Running Athena Team, the only all-women team enrolled this year, won the much coveted ATLAS Cup for the second year in a row. In fact, they are so good that Peter Schmid and Patrick Fassnacht are wondering about reducing the women's bonus in...

  10. ATLAS-Hadronic Calorimeter

    CERN Multimedia

    2003-01-01

    Hall 180 work on Hadronic Calorimeter The ATLAS hadronic tile calorimeter The Tile Calorimeter, which constitutes the central section of the ATLAS hadronic calorimeter, is a non-compensating sampling device made of iron and scintillating tiles. (IEEE Trans. Nucl. Sci. 53 (2006) 1275-81)

  11. A Slice of ATLAS

    CERN Multimedia

    2004-01-01

    An entire section of the ATLAS detector is being assembled at Prévessin. Since May the components have been tested using a beam from the SPS, giving the ATLAS team valuable experience of operating the detector as well as an opportunity to debug the system.

  12. ATLAS Brochure (english version)

    CERN Multimedia

    2004-01-01

    ATLAS is the largest detector at the LHC, the most powerful particle accelerator in the world, which will start up in 2008. ATLAS is a multi-purpose detector, designed to throw light on fundamental questions such as the origin of mass and the nature of the Universe's dark matter.

  13. ATLAS brochure (German version)

    CERN Multimedia

    Lefevre, C

    2012-01-01

    ATLAS is the largest detector at the LHC, the most powerful particle accelerator in the world. ATLAS is a multi-purpose detector, designed to throw light on fundamental questions such as the origin of mass and the nature of the Universe's dark matter.

  14. ATLAS Brochure (English version)

    CERN Multimedia

    Lefevre, Christiane

    2011-01-01

    ATLAS is the largest detector at the LHC, the most powerful particle accelerator in the world, which will start up in 2008. ATLAS is a multi-purpose detector, designed to throw light on fundamental questions such as the origin of mass and the nature of the Universe's dark matter.

  15. ATLAS brochure (Danish version)

    CERN Multimedia

    Lefevre, C

    2010-01-01

    ATLAS is the largest detector at the LHC, the most powerful particle accelerator in the world. ATLAS is a multi-purpose detector, designed to throw light on fundamental questions such as the origin of mass and the nature of the Universe's dark matter.

  16. ATLAS brochure (Italian version)

    CERN Multimedia

    Lefevre, C

    2010-01-01

    ATLAS is the largest detector at the LHC, the most powerful particle accelerator in the world. ATLAS is a multi-purpose detector, designed to throw light on fundamental questions such as the origin of mass and the nature of the Universe's dark matter.

  17. ATLAS brochure (French version)

    CERN Multimedia

    Lefevre, C

    2012-01-01

    ATLAS is the largest detector at the LHC, the most powerful particle accelerator in the world. ATLAS is a multi-purpose detector, designed to throw light on fundamental questions such as the origin of mass and the nature of the Universe's dark matter.

  18. ATLAS brochure (Catalan version)

    CERN Multimedia

    Lefevre, C

    2008-01-01

    ATLAS is the largest detector at the LHC, the most powerful particle accelerator in the world, which will start up in 2008. ATLAS is a multi-purpose detector, designed to throw light on fundamental questions such as the origin of mass and the nature of the Universe's dark matter.

  19. ATLAS Brochure (german version)

    CERN Multimedia

    Marcastel, F

    2007-01-01

    ATLAS is the largest detector at the LHC, the most powerful particle accelerator in the world, which will start up in 2008. ATLAS is a multi-purpose detector, designed to throw light on fundamental questions such as the origin of mass and the nature of the Universe's dark matter.

  20. ATLAS brochure (Polish version)

    CERN Multimedia

    Lefevre, C

    2007-01-01

    ATLAS is the largest detector at the LHC, the most powerful particle accelerator in the world, which will start up in 2008. ATLAS is a multi-purpose detector, designed to throw light on fundamental questions such as the origin of mass and the nature of the Universe's dark matter.

  1. ATLAS Brochure (english version)

    CERN Multimedia

    Marcastel, F

    2007-01-01

    ATLAS is the largest detector at the LHC, the most powerful particle accelerator in the world, which will start up in 2008. ATLAS is a multi-purpose detector, designed to throw light on fundamental questions such as the origin of mass and the nature of the Universe's dark matter.

  2. ATLAS Brochure (french version)

    CERN Multimedia

    Marcastel, F

    2007-01-01

    ATLAS is the largest detector at the LHC, the most powerful particle accelerator in the world, which will start up in 2008. ATLAS is a multi-purpose detector, designed to throw light on fundamental questions such as the origin of mass and the nature of the Universe's dark matter.

  3. ATLAS rewards industry

    CERN Multimedia

    Maximilien Brice

    2006-01-01

    For contributing vital pieces to the ATLAS puzzle, three industries were recognized on Friday 5 May during a supplier awards ceremony. After a welcome and overview of the ATLAS experiment by spokesperson Peter Jenni, CERN Secretary-General Maximilian Metzger stressed the importance of industry to CERN's scientific goals. Picture 30 : representatives of the three award-wining companies after the ceremony

  4. ATLAS Thesis Awards 2015

    CERN Multimedia

    Biondi, Silvia

    2016-01-01

    Winners of the ATLAS Thesis Award were presented with certificates and glass cubes during a ceremony on Thursday 25 February. The winners also presented their work in front of members of the ATLAS Collaboration. Winners: Javier Montejo Berlingen, Barcelona (Spain), Ruth Pöttgen, Mainz (Germany), Nils Ruthmann, Freiburg (Germany), and Steven Schramm, Toronto (Canada).

  5. ATLAS Visitors Centre

    CERN Multimedia

    claudia Marcelloni

    2009-01-01

    ATLAS Visitors Centre has opened its shiny new doors to the public. Officially launched on Monday February 23rd, 2009, the permanent exhibition at Point 1 was conceived as a tour resource for ATLAS guides, and as a way to preserve the public’s opportunity to get a close-up look at the experiment in action when the cavern is sealed.

  6. ATLAS brochure (Spanish version)

    CERN Multimedia

    Lefevre, C

    2008-01-01

    ATLAS is the largest detector at the LHC, the most powerful particle accelerator in the world, which will start up in 2008. ATLAS is a multi-purpose detector, designed to throw light on fundamental questions such as the origin of mass and the nature of the Universe's dark matter.

  7. Study of Rare Beauty Decays with ATLAS Detector at LHC and MDT Chamber Perfomances

    CERN Document Server

    Policicchio, Antonio

    2006-01-01

    The Large Hadron Collider (LHC) is a proton-proton collider that will operate at a center of mass energy of $14~TeV$ and at a maximum luminosity of $L=10^{34}cm^{-2}s^{-1}$. The LHC will reproduce interactions similar to those which existed when the universe was only $\\sim 10^{-12}s$ old, conditions which have not been achieved in any previous collider. The primary goals of the LHC project are to discover the origin of particle masses, to explain why different particles have different masses and to search for new phenomena beyond the Standard Model. Also heavy quark systems and precision measurements on Standard Model parameters will be subject of LHC physics studies. ATLAS (A Toroidal LHC ApparatuS) is one of the two LHC general purpose experiments. The guiding principle in optimizing the ATLAS experiment has been maximizing the discovery potential for New Physics such as Higgs bosons and supersymmetric particles, while keeping the capability of high precision measurements of known objects such as heavy quar...

  8. Ring-shaped Calorimetry Information for a Neural eGamma Identification with ATLAS Detector

    CERN Document Server

    Da Fonseca Pinto, Joao Victor; The ATLAS collaboration; Oliveira Damazio, Denis; Seixas, Jose

    2016-01-01

    \\title{Ring-shaped Calorimetry Information for a Neural e/$\\gamma$ Identification with ATLAS Detector} After the successful operation of the Large Hadron Collider resulting with the discovery of the Higgs boson, a new data-taking period (Run 2) has started. For the first time, collisions are produced with energies of 13 TeV in the centre of mass. It is foreseen the luminosity increase, reaching values as high as $10^{34}cm^{-2}s^{-1}$ yet in 2015. These changes in experimental conditions bring a proper environment for possible new physics key-findings. ATLAS is the largest LHC detector and was designed for general-purpose physics studies. Many potential physics channels have electrons or photons in their final states. For efficient studies on these channels precise measurement and identification of such particles is necessary. The identification task consists of disentangling those particles (signal) from collimated hadronic jets (background). Reported work concerns the identification process based on the cal...

  9. TeV jets at ATLAS. A probe for new physics

    Energy Technology Data Exchange (ETDEWEB)

    Ruehr, Frederik

    2009-01-29

    The production of particle jets will be the dominant process at the Large Hadron Collider (LHC), and jets will thus be the signal or de ne the environment of many analyses at the ATLAS experiment. Their precise measurement is a vital requirement for many potential discoveries of new physics beyond the Standard Model. The first part of this thesis introduces a new method to constrain and correct errors of the energy measurement of jets in the TeV regime. The emphasis is on a very high reach in transverse jet momenta even with earliest ATLAS data. This is achievable by an intercalibration utilizing the large inclusive jet production cross section. In the second part inclusive jet measurements are used to probe the validity of Quantum Chromodynamics (QCD). Several analyses are presented and their sensitivity is estimated using simulated data of an effective theory of a possible quark substructure. The search is then extended to effects of quantum gravity that could emerge at the LHC in scenarios of new physics, demonstrating that inclusive jet measurements are a powerful tool to probe QCD and a broad range of new physics models. (orig.)

  10. Diphoton measurements with the ATLAS detector at the LHC: search for new resonances and study of diphoton production in association with jets.

    CERN Document Server

    AUTHOR|(SzGeCERN)735473; Delmastro, Marco

    This thesis studies pp collisions at $\\sqrt{s}=8$ TeV with pairs of photons in the final state, as collected by the ATLAS experiment at the LHC during 2012. The diphoton final state has proven to be crucial to the discovery of the Higgs boson. The motivation for searching for additional resonances decaying into two photons is very strong due to many models predicting an extended Higgs sector. At the same time, detailed measurements of diphoton cross sections are necessary to establish the quality of the theoretical predictions currently available for these processes. The measurement of photons by ATLAS relies on an excellent calibration of the electromagnetic calorimeter response. For this reason, studies related to the calibration of the photon response in the ATLAS Liquid Argon (LAr) calorimeter are initially performed, including a measurement of the calorimeter layer energy scale relative calibration using photons, and the potential need of an inter-calibration of the photon energy response as a function ...

  11. Dear ATLAS colleagues,

    CERN Multimedia

    PH Department

    2008-01-01

    We are collecting old pairs of glasses to take out to Mali, where they can be re-used by people there. The price for a pair of glasses can often exceed 3 months salary, so they are prohibitively expensive for many people. If you have any old spectacles you can donate, please put them in the special box in the ATLAS secretariat, bldg.40-4-D01 before the Christmas closure on 19 December so we can take them with us when we leave for Africa at the end of the month. (more details in ATLAS e-news edition of 29 September 2008: http://atlas-service-enews.web.cern.ch/atlas-service-enews/news/news_mali.php) many thanks! Katharine Leney co-driver of the ATLAS car on the Charity Run to Mali

  12. ATLAS' major cooling project

    CERN Multimedia

    2005-01-01

    In 2005, a considerable effort has been put into commissioning the various units of ATLAS' complex cryogenic system. This is in preparation for the imminent cooling of some of the largest components of the detector in their final underground configuration. The liquid helium and nitrogen ATLAS refrigerators in USA 15. Cryogenics plays a vital role in operating massive detectors such as ATLAS. In many ways the liquefied argon, nitrogen and helium are the life-blood of the detector. ATLAS could not function without cryogens that will be constantly pumped via proximity systems to the superconducting magnets and subdetectors. In recent weeks compressors at the surface and underground refrigerators, dewars, pumps, linkages and all manner of other components related to the cryogenic system have been tested and commissioned. Fifty metres underground The helium and nitrogen refrigerators, installed inside the service cavern, are an important part of the ATLAS cryogenic system. Two independent helium refrigerators ...

  13. The Evolution of Cloud Computing in ATLAS

    Science.gov (United States)

    Taylor, Ryan P.; Berghaus, Frank; Brasolin, Franco; Domingues Cordeiro, Cristovao Jose; Desmarais, Ron; Field, Laurence; Gable, Ian; Giordano, Domenico; Di Girolamo, Alessandro; Hover, John; LeBlanc, Matthew; Love, Peter; Paterson, Michael; Sobie, Randall; Zaytsev, Alexandr

    2015-12-01

    The ATLAS experiment at the LHC has successfully incorporated cloud computing technology and cloud resources into its primarily grid-based model of distributed computing. Cloud R&D activities continue to mature and transition into stable production systems, while ongoing evolutionary changes are still needed to adapt and refine the approaches used, in response to changes in prevailing cloud technology. In addition, completely new developments are needed to handle emerging requirements. This paper describes the overall evolution of cloud computing in ATLAS. The current status of the virtual machine (VM) management systems used for harnessing Infrastructure as a Service resources are discussed. Monitoring and accounting systems tailored for clouds are needed to complete the integration of cloud resources within ATLAS' distributed computing framework. We are developing and deploying new solutions to address the challenge of operation in a geographically distributed multi-cloud scenario, including a system for managing VM images across multiple clouds, a system for dynamic location-based discovery of caching proxy servers, and the usage of a data federation to unify the worldwide grid of storage elements into a single namespace and access point. The usage of the experiment's high level trigger farm for Monte Carlo production, in a specialized cloud environment, is presented. Finally, we evaluate and compare the performance of commercial clouds using several benchmarks.

  14. Distributed analysis in ATLAS using GANGA

    Science.gov (United States)

    Elmsheuser, Johannes; Brochu, Frederic; Cowan, Greig; Egede, Ulrik; Gaidioz, Benjamin; Lee, Hurng-Chun; Maier, Andrew; Móscicki, Jakub; Pajchel, Katarina; Reece, Will; Samset, Bjorn; Slater, Mark; Soroko, Alexander; Vanderster, Daniel; Williams, Michael

    2010-04-01

    Distributed data analysis using Grid resources is one of the fundamental applications in high energy physics to be addressed and realized before the start of LHC data taking. The needs to manage the resources are very high. In every experiment up to a thousand physicists will be submitting analysis jobs to the Grid. Appropriate user interfaces and helper applications have to be made available to assure that all users can use the Grid without expertise in Grid technology. These tools enlarge the number of Grid users from a few production administrators to potentially all participating physicists. The GANGA job management system (http://cern.ch/ganga), developed as a common project between the ATLAS and LHCb experiments, provides and integrates these kind of tools. GANGA provides a simple and consistent way of preparing, organizing and executing analysis tasks within the experiment analysis framework, implemented through a plug-in system. It allows trivial switching between running test jobs on a local batch system and running large-scale analyzes on the Grid, hiding Grid technicalities. We will be reporting on the plug-ins and our experiences of distributed data analysis using GANGA within the ATLAS experiment. Support for all Grids presently used by ATLAS, namely the LCG/EGEE, NDGF/NorduGrid, and OSG/PanDA is provided. The integration and interaction with the ATLAS data management system DQ2 into GANGA is a key functionality. An intelligent job brokering is set up by using the job splitting mechanism together with data-set and file location knowledge. The brokering is aided by an automated system that regularly processes test analysis jobs at all ATLAS DQ2 supported sites. Large numbers of analysis jobs can be sent to the locations of data following the ATLAS computing model. GANGA supports amongst other things tasks of user analysis with reconstructed data and small scale production of Monte Carlo data.

  15. ATLAS Forward Detectors and Physics

    CERN Document Server

    Soni, N

    2010-01-01

    In this communication I describe the ATLAS forward physics program and the detectors, LUCID, ZDC and ALFA that have been designed to meet this experimental challenge. In addition to their primary role in the determination of ATLAS luminosity these detectors - in conjunction with the main ATLAS detector - will be used to study soft QCD and diffractive physics in the initial low luminosity phase of ATLAS running. Finally, I will briefly describe the ATLAS Forward Proton (AFP) project that currently represents the future of the ATLAS forward physics program.

  16. Travel in the heart of matter: the Atlas experiment at CERN, pop-up book; Voyage au coeur de la matiere: l'experience Atlas au CERN, Livre anime

    Energy Technology Data Exchange (ETDEWEB)

    Sanders, Emma; Radevsky, Anton; Blanche, Eugenie

    2011-12-01

    This 'pop-up' book, fully illustrated, proposes a travel towards the birth of the universe through Atlas, one of the four particle physics experiments at the Large Hadron Collider at CERN (LHC). The ATLAS detector is searching for new discoveries in the head-on collisions of protons of extraordinarily high energy. ATLAS will learn about the basic forces that have shaped our Universe since the beginning of time and that will determine its fate. Among the possible unknowns are the search for the Higgs boson, the origin of mass, the extra dimensions of space, the unification of fundamental forces, and evidence for dark matter candidates in the Universe

  17. Integration Of PanDA Workload Management System With Supercomputers for ATLAS

    CERN Document Server

    Oleynik, Danila; The ATLAS collaboration; De, Kaushik; Wenaus, Torre; Maeno, Tadashi; Barreiro Megino, Fernando Harald; Nilsson, Paul; Guan, Wen; Panitkin, Sergey

    2016-01-01

    The Large Hadron Collider (LHC), operating at the international CERN Laboratory in Geneva, Switzerland, is leading Big Data driven scientific explorations. Experiments at the LHC explore the fundamental nature of matter and the basic forces that shape our universe, and were recently credited for the discovery of a Higgs boson. ATLAS, one of the largest collaborations ever assembled in the sciences, is at the forefront of research at the LHC. To address an unprecedented multi-petabyte data processing challenge, the ATLAS experiment is relying on a heterogeneous distributed computational infrastructure. The ATLAS experiment uses PanDA (Production ANd Distributed Analysis system) Workload Management System for managing the workflow for all data processing on over 150 data centers. Through PanDA, ATLAS physicists see a single computing facility that enables rapid scientific breakthroughs for the experiment, even though the data centers are physically scattered all over the world. While PanDA currently uses more t...

  18. EnviroAtlas - Memphis, TN - EnviroAtlas Community Boundary

    Data.gov (United States)

    U.S. Environmental Protection Agency — This EnviroAtlas dataset shows the boundary of the Memphis, TN EnviroAtlas Community. It represents the outside edge of all the block groups included in the...

  19. Exploring the effect of N-substitution in nor-lobelane on the interaction with VMAT2: discovery of a potential clinical candidate for treatment of methamphetamine abuse.

    Science.gov (United States)

    Zheng, Guangrong; Horton, David B; Penthala, Narsimha Reddy; Nickell, Justin R; Culver, John P; Deaciuc, Agripina G; Dwoskin, Linda P; Crooks, Peter A

    2013-03-01

    A series of N-substituted lobelane analogues was synthesized and evaluated for their [(3)H]dihydrotetrabenazine binding affinity at the vesicular monoamine transporter and for their inhibition of vesicular [(3)H]dopamine uptake. Compound 19a, which contains an N-1,2(R)-dihydroxypropyl group, had been identified as a potential clinical candidate for the treatment of methamphetamine abuse.

  20. Ceremony for ATLAS cavern

    CERN Multimedia

    2003-01-01

    Wednesday 4 June will be a special day for CERN. The President of the Swiss Confederation, Pascal Couchepin, will officially inaugurate the huge ATLAS cavern now that the civil engineering works have ended. The inauguration ceremony will be held in the ATLAS surface building, with speeches by Pascal Couchepin and CERN, ATLAS and civil engineering personalities. This ceremony will be Webcast live. To access the Webcast on 4 June at 18h00 go to CERN Intranet home page or the following address : http://webcast.cern.ch/live.php

  1. ATLAS Inner Detector Alignment

    CERN Document Server

    Bocci, A

    2008-01-01

    The ATLAS experiment is a multi-purpose particle detector that will study high-energy particle collisions produced by the Large Hadron Collider at CERN. In order to achieve its physics goals, the ATLAS tracking requires that the positions of the silicon detector elements have to be known to a precision better than 10 μm. Several track-based alignment algorithms have been developed for the Inner Detector. An extensive validation has been performed with simulated events and real data coming from the ATLAS. Results from such validation are reported in this paper.

  2. World-wide online monitoring interface of the ATLAS experiment

    CERN Document Server

    Kolos, S; The ATLAS collaboration; Mineev, M; Hauser, R; Salnikov, A

    2014-01-01

    The ATLAS collaboration accounts for more than 3000 members located all over the world. The efficiency of the experiment can be improved allowing system experts not present on site to follow the ATLAS operations in real-time, spotting potential problems which otherwise may remain unattended for a non-negligible time. Taking into account the wide geographical spread of the ATLAS collaboration, the solution of this problem is to have all monitoring information with minimal access latency available world-wide. We have implemented a framework which defines a standard approach for retrieving arbitrary monitoring information from the ATLAS private network via HTTP. An information request is made by specifying one of the predefined URLs with some optional parameters refining data which has to be shipped back in XML format. The framework takes care of receiving, parsing and forwarding such requests to the appropriate plugins. The plugins retrieve the requested data and convert it to XML (or optionally to JSON) format...

  3. ATLAS@Home: Harnessing Volunteer Computing for HEP

    Science.gov (United States)

    Adam-Bourdarios, C.; Cameron, D.; Filipčič, A.; Lancon, E.; Wu, W.; ATLAS Collaboration

    2015-12-01

    A recent common theme among HEP computing is exploitation of opportunistic resources in order to provide the maximum statistics possible for Monte Carlo simulation. Volunteer computing has been used over the last few years in many other scientific fields and by CERN itself to run simulations of the LHC beams. The ATLAS@Home project was started to allow volunteers to run simulations of collisions in the ATLAS detector. So far many thousands of members of the public have signed up to contribute their spare CPU cycles for ATLAS, and there is potential for volunteer computing to provide a significant fraction of ATLAS computing resources. Here we describe the design of the project, the lessons learned so far and the future plans.

  4. ATLAS@Home: Harnessing Volunteer Computing for HEP

    CERN Document Server

    Bourdarios, Claire; Filipcic, Andrej; Lancon, Eric; Wu, Wenjing

    2015-01-01

    A recent common theme among HEP computing is exploitation of opportunistic resources in order to provide the maximum statistics possible for Monte-Carlo simulation. Volunteer computing has been used over the last few years in many other scientific fields and by CERN itself to run simulations of the LHC beams. The ATLAS@Home project was started to allow volunteers to run simulations of collisions in the ATLAS detector. So far many thousands of members of the public have signed up to contribute their spare CPU cycles for ATLAS, and there is potential for volunteer computing to provide a significant fraction of ATLAS computing resources. Here we describe the design of the project, the lessons learned so far and the future plans.

  5. ATLAS Event - First Splash of Particles in ATLAS

    CERN Multimedia

    ATLAS Outreach

    2008-01-01

    A simulated event. September 10, 2008 - The ATLAS detector lit up as a flood of particles traversed the detector when the beam was occasionally directed at a target near ATLAS. This allowed ATLAS physicists to study how well the various components of the detector were functioning in preparation for the forthcoming collisions. The first ATLAS data recorded on September 10, 2008 is seen here. Running time 24 seconds

  6. Recent ATLAS Articles on WLAP

    CERN Multimedia

    Goldfarb, S.

    As reported in the September 2004 ATLAS eNews, the Web Lecture Archive Project is a system for the archiving and publishing of multimedia presentations, using the Web as medium. We list here newly available WLAP items relating to ATLAS: June ATLAS Plenary Meeting Tutorial on Physics EDM and Tools (June) Freiburg Overview Week Ketevi Assamagan's Tutorial on Analysis Tools Click here to browse WLAP for all ATLAS lectures.

  7. Recent results from ATLAS experiment

    CERN Document Server

    Smirnov, Sergei; The ATLAS collaboration

    2016-01-01

    The 2nd LHC run has started in 2015 with a pp centre-of-mass collision energy of 13 TeV and ATLAS has taken more than 20 fb-1 of data at the new energy by 2016 summer. In this talk, an overview is given on the ATLAS data taking and the improvements made to the ATLAS experiment during the 2-year shutdown 2013/2014. Selected new results from the recent data analysis from ATLAS is also presented.

  8. ATLAS TV PROJECT

    CERN Multimedia

    OMNI communication

    2006-01-01

    CERN, Building 40 Interview with theorist Mr. Philip Hinchliffe (Berkeley) as well an interview with his wife Mrs. Hinchliffe who is also Physics Department head at Berkeley. They are both working in ATLAS Experiment.

  9. California Ocean Uses Atlas

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset is a result of the California Ocean Uses Atlas Project: a collaboration between NOAA's National Marine Protected Areas Center and Marine Conservation...

  10. Lunar Sample Atlas

    Data.gov (United States)

    National Aeronautics and Space Administration — The Lunar Sample Atlas provides pictures of the Apollo samples taken in the Lunar Sample Laboratory, full-color views of the samples in microscopic thin-sections,...

  11. The Latest from ATLAS

    CERN Multimedia

    2009-01-01

    Since November 2008, ATLAS has undertaken detailed maintenance, consolidation and repair work on the detector (see Bulletin of 20 July 2009). Today, the fraction of the detector that is operational has increased compared to last year: less than 1% of dead channels for most of the sub-systems. "We are going to start taking data this year with a detector which is even more efficient than it was last year," agrees ATLAS Spokesperson, Fabiola Gianotti. By mid-September the detector was fully closed again, and the cavern sealed. The magnet system has been operated at nominal current for extensive periods over recent months. Once the cavern was sealed, ATLAS began two weeks of combined running. Right now, subsystems are joining the run incrementally until the point where the whole detector is integrated and running as one. In the words of ATLAS Technical Coordinator, Marzio Nessi: "Now we really start physics." In parallel, the analysis ...

  12. PeptideAtlas

    Data.gov (United States)

    U.S. Department of Health & Human Services — PeptideAtlas is a multi-organism, publicly accessible compendium of peptides identified in a large set of tandem mass spectrometry proteomics experiments. Mass...

  13. ATLAS Cavern baseplate

    CERN Multimedia

    It-UDS-Audiovisual Services

    2002-01-01

    This video shows the incredible amounth of iron used for ATLAS cavern. Please look at the related links and also videos that are concerning the civil engineering where you can see even more detailed cavern excavation work.

  14. Printed circuit for ATLAS

    CERN Multimedia

    Laurent Guiraud

    1999-01-01

    A printed circuit board made by scientists in the ATLAS collaboration for the transition radiaton tracker (TRT). This will read data produced when a high energy particle crosses the boundary between two materials with different electrical properties.

  15. ATLAS DAQ Configuration Databases

    Institute of Scientific and Technical Information of China (English)

    I.Alexandrov; A.Amorim; 等

    2001-01-01

    The configuration databases are an important part of the Trigger/DAQ system of the future ATLAS experiment .This paper describes their current status giving details of architecture,implementation,test results and plans for future work.

  16. ATLAS TV PROJECT

    CERN Multimedia

    2005-01-01

    ATLAS Physics Workshop at the University of Roma Tre held from Monday 06 June 2005 to Saturday 11 June 2005. Experts establishing workshop, poster, people milling Shots of Peter Jenni introduction Many audience shots Sequences from various talks

  17. General Dynamics Atlas family

    Science.gov (United States)

    Oates, James

    Developments concerning the Atlas family of launch vehicles over the last three or four years are summarized. Attention is given to the center of gravity, load factors, acoustics, pyroshock, low-frequency sinusoidal vibration, and high-frequency random vibration.

  18. Discovery of the Potential Role of Sensors in a Personal Emergency Response System: What Can We Learn from a Single Workshop?

    Directory of Open Access Journals (Sweden)

    Femke De Backere

    2015-12-01

    Full Text Available Capturing knowledge from domain experts is important to effectively integrate novel technological support in existing care processes. In this paper, we present our experiences in using a specific type of workshop, which we identified as a decision-tree workshop, to determine the process and information exchange during the usage of a Personal Emergency Response System (PERS. We conducted the workshop with current and possible future users of a PERS system to investigate the potential of context- and social awareness for such a system. We discuss the workshop format as well as the results and reflection on this workshop.

  19. ATLAS Civil Engineering Point 1

    CERN Multimedia

    Jean-Claude Vialis

    1999-01-01

    Different phases of realisation to Point 1 : zone of the ATLAS experiment The ATLAS experimental area is located in Point 1, just across the main CERN entrance, in the commune of Meyrin. There people are ever so busy to finish the different infrastructures for ATLAS. Real underground video. The film has original working sound.

  20. Population genetic structure of Phytophthora cinnamomi associated with avocado in California and the discovery of a potentially recent introduction of a new clonal lineage.

    Science.gov (United States)

    Pagliaccia, D; Pond, E; McKee, B; Douhan, G W

    2013-01-01

    Phytophthora root rot (PRR) of avocado (Persea americana), caused by Phytophthora cinnamomi, is the most serious disease of avocado worldwide. Previous studies have determined that this pathogen exhibits a primarily clonal reproductive mode but no population level studies have been conducted in the avocado-growing regions of California. Therefore, we used amplified fragment length polymorphism based on 22 polymorphic loci and mating type to investigate pathogen diversity from 138 isolates collected in 2009 to 2010 from 15 groves from the Northern and Southern avocado-growing regions. Additional isolates collected from avocado from 1966 to 2007 as well as isolates from other countries and hosts were also used for comparative purposes. Two distinct clades of A2 mating-type isolates from avocado were found based on neighbor joining analysis; one clade contained both newer and older collections from Northern and Southern California, whereas the other clade only contained isolates collected in 2009 and 2010 from Southern California. A third clade was also found that only contained A1 isolates from various hosts. Within the California population, a total of 16 genotypes were found with only one to four genotypes identified from any one location. The results indicate significant population structure in the California avocado P. cinnamomi population, low genotypic diversity consistent with asexual reproduction, potential evidence for the movement of clonal genotypes between the two growing regions, and a potential introduction of a new clonal lineage into Southern California.

  1. Population genetic structure of Phytophthora cinnamomi associated with avocado in California and the discovery of a potentially recent introduction of a new clonal lineage.

    Science.gov (United States)

    Pagliaccia, D; Pond, E; McKee, B; Douhan, G W

    2013-01-01

    Phytophthora root rot (PRR) of avocado (Persea americana), caused by Phytophthora cinnamomi, is the most serious disease of avocado worldwide. Previous studies have determined that this pathogen exhibits a primarily clonal reproductive mode but no population level studies have been conducted in the avocado-growing regions of California. Therefore, we used amplified fragment length polymorphism based on 22 polymorphic loci and mating type to investigate pathogen diversity from 138 isolates collected in 2009 to 2010 from 15 groves from the Northern and Southern avocado-growing regions. Additional isolates collected from avocado from 1966 to 2007 as well as isolates from other countries and hosts were also used for comparative purposes. Two distinct clades of A2 mating-type isolates from avocado were found based on neighbor joining analysis; one clade contained both newer and older collections from Northern and Southern California, whereas the other clade only contained isolates collected in 2009 and 2010 from Southern California. A third clade was also found that only contained A1 isolates from various hosts. Within the California population, a total of 16 genotypes were found with only one to four genotypes identified from any one location. The results indicate significant population structure in the California avocado P. cinnamomi population, low genotypic diversity consistent with asexual reproduction, potential evidence for the movement of clonal genotypes between the two growing regions, and a potential introduction of a new clonal lineage into Southern California. PMID:23228146

  2. Budker INP in ATLAS

    CERN Multimedia

    2001-01-01

    The Novosibirsk group has proposed a new design for the ATLAS liquid argon electromagnetic end-cap calorimeter with a constant thickness of absorber plates. This design has signifi- cant advantages compared to one in the Technical Proposal and it has been accepted by the ATLAS Collaboration. The Novosibirsk group is responsible for the fabrication of the precision aluminium structure for the e.m.end-cap calorimeter.

  3. ATLAS Transitional Radiation Tracker

    CERN Multimedia

    ATLAS Outreach

    2006-01-01

    This colorful 3D animation is an excerpt from the film "ATLAS-Episode II, The Particles Strike Back." Shot with a bug's eye view of the inside of the detector. The viewer is taken on a tour of the inner workings of the transitional radiation tracker within the ATLAS detector. Subjects covered include what the tracker is used to measure, its structure, what happens when particles pass through the tracker, how it distinguishes between different types of particles within it.

  4. The ATLAS electromagnetic calorimeter

    CERN Document Server

    Maximilien Brice

    2003-01-01

    Michel Mathieu, a technician for the ATLAS collaboration, is cabling the ATLAS electromagnetic calorimeter's first end-cap, before insertion into its cryostat. Millions of wires are connected to the electromagnetic calorimeter on this end-cap that must be carefully fed out from the detector so that data can be read out. Every element on the detector will be attached to one of these wires so that a full digital map of the end-cap can be recreated.

  5. ATLAS Jet Energy Scale

    OpenAIRE

    D. Schouten; Tanasijczuk, A.; Vetterli, M.(Department of Physics, Simon Fraser University, Burnaby, BC, Canada); Collaboration, for the ATLAS

    2012-01-01

    Jets originating from the fragmentation of quarks and gluons are the most common, and complicated, final state objects produced at hadron colliders. A precise knowledge of their energy calibration is therefore of great importance at experiments at the Large Hadron Collider at CERN, while is very difficult to ascertain. We present in-situ techniques and results for the jet energy scale at ATLAS using recent collision data. ATLAS has demonstrated an understanding of the necessary jet energy cor...

  6. Discovery Mondays - 'Globe-trotting detectors'

    CERN Multimedia

    2007-01-01

    Transportation of one of the ATLAS barrel toroids (Photo Peter Ginter). From Chicago to Athens via Liverpool, the detector components for the LHC experiments travel high and low before converging on Geneva for their final assembly at CERN. Thousands of scientists from 85 countries across the world are participating in the ALICE, ATLAS, CMS and LHCb experiments, each making their own contribution to the overall project, whether in the production of the sub-detectors, the preparation of the physics or the analysis of the data. At this Discovery Monday you will witness the collaborations' whistle-stop world tour and see some of the extraordinary means of transport that convey the detector parts all the way to CERN's doorstep. All aboard for this remarkable trip around the world in ninety minutes! The event will be conducted in French. Come to the Microcosm (Reception Building 33, Meyrin site) on Monday, 7 May from 7.30 p.m. to 9.00 p.m. Entrance Free http://www.cern.ch/LundisDecouverte/

  7. Discovery Mondays - 'Globe-trotting detectors'

    CERN Multimedia

    2007-01-01

    Transportation of one of the ATLAS barrel toroids (Photo Peter Ginter). From Chicago to Athens via Liverpool, the detector components for the LHC experiments travel high and low before converging on Geneva for their final assembly at CERN. Thousands of scientists from 85 countries across the world are participating in the ALICE, ATLAS, CMS and LHCb experiments, each making their own contribution to the overall project, whether in the production of the sub-detectors, the preparation of the physics or the analysis of the data. At this Discovery Monday you will witness the collaborations' whistle-stop world tour and see some of the extraordinary means of transport that convey the detector parts all the way to CERN's doorstep. All aboard for this remarkable trip around the world in ninety minutes ! The event will be conducted in French. Come to the Microcosm (Reception Building 33, Meyrin site) on Monday, 7 May from 7.30 p.m. to 9.00 p.m. Entrance Free http://www.cern.ch/LundisDecouverte/

  8. ATLAS Facility Description Report

    International Nuclear Information System (INIS)

    A thermal-hydraulic integral effect test facility, ATLAS (Advanced Thermal-hydraulic Test Loop for Accident Simulation), has been constructed at KAERI (Korea Atomic Energy Research Institute). The ATLAS has the same two-loop features as the APR1400 and is designed according to the well-known scaling method suggested by Ishii and Kataoka to simulate the various test scenarios as realistically as possible. It is a half-height and 1/288-volume scaled test facility with respect to the APR1400. The fluid system of the ATLAS consists of a primary system, a secondary system, a safety injection system, a break simulating system, a containment simulating system, and auxiliary systems. The primary system includes a reactor vessel, two hot legs, four cold legs, a pressurizer, four reactor coolant pumps, and two steam generators. The secondary system of the ATLAS is simplified to be of a circulating loop-type. Most of the safety injection features of the APR1400 and the OPR1000 are incorporated into the safety injection system of the ATLAS. In the ATLAS test facility, about 1300 instrumentations are installed to precisely investigate the thermal-hydraulic behavior in simulation of the various test scenarios. This report describes the scaling methodology, the geometric data of the individual component, and the specification and the location of the instrumentations in detail

  9. Optimization of the ATLAS detector to search for the two-photon decaying Higgs boson at LHC; Optimisation du detecteur ATLAS pour la recherche du boson de Higgs se desintegrant en deux photons au LHC

    Energy Technology Data Exchange (ETDEWEB)

    Tisserand, V. [Paris-11 Univ., 91 - Orsay (France). Lab. de l' Accelerateur Lineaire]|[Universite de Paris Sud, 91 - Orsay (France)

    1997-02-03

    The two photon decay channel is the most clear and promising way to detect a Higgs boson of an intermediate mass between 80 GeV/c{sup 2} and 150 GeV/c{sup 2} at the future large proton collider of CERN (LHC). As the Higgs mass is narrow in this range, the observation of this channel relies on the performance of the electromagnetic calorimeter. A full simulation study has been performed to evaluate the discovery potential of the ATLAS detector. The results of this simulation have been confirmed by beam tests with a prototype. This simulation includes different contributions such as energy resolution sampling term, electronic and pile-up noise, global constant term and angular measurement of the two photon opening angle. The levels of the irreducible background from prompt di-photon production and the reducible background from jets with isolated leading neutrals pions have been estimated, taking into account the rejection capability of the detector. After the computation of the two photon invariant mass resolution, and the evaluation of signal and background rates, the discovery potential of the Higgs boson with the ATLAS detector was calculated. The Higgs can be discovered at five sigma confidence level after less than a year of data taking at LHC with the nominal luminosity of 10{sup 34} cm{sup -2}.s{sup -1} if the Higgs mass is between 100 GeV/c{sup 2} and 150 GeV/c{sup 2}. The Higgs mass window between 80 GeV/c{sup 2} and 150 GeV/c{sup 2} will be covered with an integrated luminosity of 3.10{sup 5} pb{sup -1}. In the case of the Minimal Supersymmetric Model (MSSM) the plane (m{sub A{sup 0}}, tan({beta})) will be fully explored if m{sub A{sup 0}} > 175 GeV/c{sup 2}. (author)

  10. Virtual Visit to the ATLAS Control Room by the University of Bern

    CERN Multimedia

    ATLAS Experiment

    2012-01-01

    Fresher's day for potential future bachelor students Infotage für Studieninteressierte Bachelor Once a year the University of Bern organizes two information days for young potential future bachelor students. Young aspiring candidates interested in a career in physics will be shown the forefront of physics research, where a trip around the university physics laboratories, and a direct video link to the ATLAS Control room at CERN's Large Hadron Collider is part of the program. A physicist from Bern will present directly from the ATLAS control room for a direct and personal view into the physics at the LHC, the Higgs particle, the generation of mass, antimatter, the origin of the universe and the involvement of the Bern high-energy physics team in the ATLAS experiment. This also allows for fruitful discussions about their own perspectives of perhaps becoming a CERN physicist one day. http://atlas-live-virtual-visit.web.cern.ch/atlas-live-virtual-visit/2012/Bern-2012.html

  11. Sampling: Making Electronic Discovery More Cost Effective

    Directory of Open Access Journals (Sweden)

    Milton Luoma

    2011-06-01

    Full Text Available With the huge volumes of electronic data subject to discovery in virtually every instance of litigation, time and costs of conducting discovery have become exceedingly important when litigants plan their discovery strategies.  Rather than incurring the costs of having lawyers review every document produced in response to a discovery request in search of relevant evidence, a cost effective strategy for document review planning is to use statistical sampling of the database of documents to determine the likelihood of finding relevant evidence by reviewing additional documents.  This paper reviews and discusses how sampling can be used to make document review more cost effective by considering issues such as an appropriate sample size, how to develop a sampling strategy, and taking into account the potential value of the litigation in relation to the costs of additional discovery efforts. 

  12. Reassessing the discovery potential of the B →K*ℓ+ℓ- decays in the large-recoil region: SM challenges and BSM opportunities

    Science.gov (United States)

    Jäger, S.; Martin Camalich, J.

    2016-01-01

    We critically examine the potential to disentangle the Standard Model (SM) and new physics (NP) in B →K*μ+μ- and B →K*e+e- decays, focusing on (i) the LHCb anomaly, (ii) the search for right-handed currents, and (iii) lepton-universality violation. Restricting ourselves to the large-recoil region, we advocate a parametrization of the hadronic matrix elements that separates model-independent information about nonperturbative QCD from the results of model calculations. We clarify how to estimate corrections to the heavy-quark limit that would generate a right-handed (virtual) photon in the b →s γ contribution to the decay. We then apply this approach to the discussion of various sets of observables of increasing theoretical cleanness. First, we show that angular observables in the optimized Pi(') basis are, in general, still not robust against the long-distance QCD effects, both numerically and by examining analytically the dependence on corrections to the (model-independent) heavy-quark limit. As a result, while a fit to data favors a NP contribution to the semileptonic operators of the type δ C9≃-1.5 , this comes at a relatively small statistical significance of ≲2 σ once such power corrections are properly accounted for. Second, two of these observables, P1 and P3C P, are particularly clean at very low q2 and sensitive probes of right-handed quark currents. We discuss their potential to set stringent bounds on the Wilson coefficient C7', especially using data of the electronic mode, and we update the bounds with current angular data in the muonic channel. Finally, in light of the recent hint of lepton-universality violation in B+→K+ℓℓ , we introduce and investigate new lepton-universality observables involving angular observables of the muonic and electronic modes and their zero crossings and show that, if the effect is of the size suggested by experiment, these can clearly distinguish between different NP explanations in terms of underlying

  13. Computational drug discovery

    Institute of Scientific and Technical Information of China (English)

    Si-sheng OU-YANG; Jun-yan LU; Xiang-qian KONG; Zhong-jie LIANG; Cheng LUO; Hualiang JIANG

    2012-01-01

    Computational drug discovery is an effective strategy for accelerating and economizing drug discovery and development process.Because of the dramatic increase in the availability of biological macromolecule and small molecule information,the applicability of computational drug discovery has been extended and broadly applied to nearly every stage in the drug discovery and development workflow,including target identification and validation,lead discovery and optimization and preclinical tests.Over the past decades,computational drug discovery methods such as molecular docking,pharmacophore modeling and mapping,de novo design,molecular similarity calculation and sequence-based virtual screening have been greatly improved.In this review,we present an overview of these important computational methods,platforms and successful applications in this field.

  14. Discovery of A-971432, An Orally Bioavailable Selective Sphingosine-1-Phosphate Receptor 5 (S1P5) Agonist for the Potential Treatment of Neurodegenerative Disorders.

    Science.gov (United States)

    Hobson, Adrian D; Harris, Christopher M; van der Kam, Elizabeth L; Turner, Sean C; Abibi, Ayome; Aguirre, Ana L; Bousquet, Peter; Kebede, Tegest; Konopacki, Donald B; Gintant, Gary; Kim, Youngjae; Larson, Kelly; Maull, John W; Moore, Nigel S; Shi, Dan; Shrestha, Anurupa; Tang, Xiubo; Zhang, Peng; Sarris, Kathy K

    2015-12-10

    S1P5 is one of 5 receptors for sphingosine-1-phosphate and is highly expressed on endothelial cells within the blood-brain barrier, where it maintains barrier integrity in in vitro models (J. Neuroinflamm. 2012, 9, 133). Little more is known about the effects of S1P5 modulation due to the absence of tool molecules with suitable selectivity and drug-like properties. We recently reported that molecule A-971432 (Harris, 2010) (29 in this paper) is highly efficacious in reversing lipid accumulation and age-related cognitive decline in rats (Van der Kam , , AAIC 2014). Herein we describe the development of a series of selective S1P5 agonists that led to the identification of compound 29, which is highly selective for S1P5 and has excellent plasma and CNS exposure after oral dosing in preclinical species. To further support its suitability for in vivo studies of S1P5 biology, we extensively characterized 29, including confirmation of its selectivity in pharmacodynamic assays of S1P1 and S1P3 function in rats. In addition, we found that 29 improves blood-brain barrier integrity in an in vitro model and reverses age-related cognitive decline in mice. These results suggest that S1P5 agonism is an innovative approach with potential benefit in neurodegenerative disorders involving lipid imbalance and/or compromised blood-brain barrier such as Alzheimer's disease or multiple sclerosis. PMID:26509640

  15. Reassessing the discovery potential of the $B \\to K^{*} \\ell^+\\ell^-$ decays in the large-recoil region: SM challenges and BSM opportunities

    CERN Document Server

    Jäger, Sebastian

    2014-01-01

    We critically examine the potential to disentangle Standard Model (SM) and New Physics (NP) in $B \\to K^* \\mu^+\\mu^-$ and $B\\to K^* e^+ e^-$ decays, focusing on $(i)$ the LHCb anomaly, $(ii)$ the search for right-handed currents, and $(iii)$ lepton-universality violation. Restricting ourselves to the large-recoil region, we advocate a parameterisation of the hadronic matrix elements that separates model-independent information about nonperturbative QCD from the results of model calculations. We clarify how to estimate corrections to the heavy-quark limit that would generate a right-handed (virtual) photon in the $b\\to s\\gamma$ contribution to the decay. We then apply this approach to the discussion of various sets of observables of increasing theoretical cleanness. First, we show that angular observables in the optimized $P_i^{(\\prime)}$ basis are, in general, not robust against the long-distance QCD effects. While a fit to data shows a preference towards new-physics contributions in semileptonic operators, t...

  16. Discovery of novel PDE9 inhibitors capable of inhibiting Aβ aggregation as potential candidates for the treatment of Alzheimer’s disease

    Science.gov (United States)

    Su, Tao; Zhang, Tianhua; Xie, Shishun; Yan, Jun; Wu, Yinuo; Li, Xingshu; Huang, Ling; Luo, Hai-Bin

    2016-02-01

    Recently, phosphodiesterase-9 (PDE9) inhibitors and biometal-chelators have received much attention as potential therapeutics for the treatment of Alzheimer’s disease (AD). Here, we designed, synthesized, and evaluated a novel series of PDE9 inhibitors with the ability to chelate metal ions. The bioassay results showed that most of these molecules strongly inhibited PDE9 activity. Compound 16 showed an IC50 of 34 nM against PDE9 and more than 55-fold selectivity against other PDEs. In addition, this compound displayed remarkable metal-chelating capacity and a considerable ability to halt copper redox cycling. Notably, in comparison to the reference compound clioquinol, it inhibited metal-induced Aβ1-42 aggregation more effectively and promoted greater disassembly of the highly structured Aβ fibrils generated through Cu2+-induced Aβ aggregation. These activities of 16, together with its favorable blood-brain barrier permeability, suggest that 16 may be a promising compound for treatment of AD.

  17. Metagenomic small molecule discovery methods

    OpenAIRE

    Charlop-Powers, Zachary; Milshteyn, Aleksandr; Brady, Sean F

    2014-01-01

    Metagenomic approaches to natural product discovery provide the means of harvesting bioactive small molecules synthesized by environmental bacteria without the requirement of first culturing these organisms. Advances in sequencing technologies and general metagenomic methods are beginning to provide the tools necessary to unlock the unexplored biosynthetic potential encoded by the genomes of uncultured environmental bacteria. Here, we highlight recent advances in sequence- and functional- bas...

  18. Towards Discovery of Subgraph Bisociations

    OpenAIRE

    Nagel, Uwe; Thiel, Kilian; Kötter, Tobias; Piatek, Dawid; Berthold, Michael R

    2012-01-01

    The discovery of surprising relations in large, heterogeneous information repositories is gaining increasing importance in real world data analysis. If these repositories come from diverse origins, forming different domains, domain bridging associations between otherwise weakly connected domains can provide insights into the data that are not accomplished by aggregative approaches. In this paper, we propose a first formalization for the detection of such potentially interesting, domaincrossin...

  19. EnviroAtlas - Metrics for Austin, TX

    Data.gov (United States)

    U.S. Environmental Protection Agency — This EnviroAtlas web service supports research and online mapping activities related to EnviroAtlas (https://enviroatlas.epa.gov/EnviroAtlas). The layers in this...

  20. The potent Cdc7-Dbf4 (DDK) kinase inhibitor XL413 has limited activity in many cancer cell lines and discovery of potential new DDK inhibitor scaffolds.

    Science.gov (United States)

    Sasi, Nanda Kumar; Tiwari, Kanchan; Soon, Fen-Fen; Bonte, Dorine; Wang, Tong; Melcher, Karsten; Xu, H Eric; Weinreich, Michael

    2014-01-01

    Cdc7-Dbf4 kinase or DDK (Dbf4-dependent kinase) is required to initiate DNA replication by phosphorylating and activating the replicative Mcm2-7 DNA helicase. DDK is overexpressed in many tumor cells and is an emerging chemotherapeutic target since DDK inhibition causes apoptosis of diverse cancer cell types but not of normal cells. PHA-767491 and XL413 are among a number of potent DDK inhibitors with low nanomolar IC50 values against the purified kinase. Although XL413 is highly selective for DDK, its activity has not been extensively characterized on cell lines. We measured anti-proliferative and apoptotic effects of XL413 on a panel of tumor cell lines compared to PHA-767491, whose activity is well characterized. Both compounds were effective biochemical DDK inhibitors but surprisingly, their activities in cell lines were highly divergent. Unlike PHA-767491, XL413 had significant anti-proliferative activity against only one of the ten cell lines tested. Since XL413 did not effectively inhibit DDK in multiple cell lines, this compound likely has limited bioavailability. To identify potential leads for additional DDK inhibitors, we also tested the cross-reactivity of ∼400 known kinase inhibitors against DDK using a DDK thermal stability shift assay (TSA). We identified 11 compounds that significantly stabilized DDK. Several inhibited DDK with comparable potency to PHA-767491, including Chk1 and PKR kinase inhibitors, but had divergent chemical scaffolds from known DDK inhibitors. Taken together, these data show that several well-known kinase inhibitors cross-react with DDK and also highlight the opportunity to design additional specific, biologically active DDK inhibitors for use as chemotherapeutic agents.

  1. The potent Cdc7-Dbf4 (DDK kinase inhibitor XL413 has limited activity in many cancer cell lines and discovery of potential new DDK inhibitor scaffolds.

    Directory of Open Access Journals (Sweden)

    Nanda Kumar Sasi

    Full Text Available Cdc7-Dbf4 kinase or DDK (Dbf4-dependent kinase is required to initiate DNA replication by phosphorylating and activating the replicative Mcm2-7 DNA helicase. DDK is overexpressed in many tumor cells and is an emerging chemotherapeutic target since DDK inhibition causes apoptosis of diverse cancer cell types but not of normal cells. PHA-767491 and XL413 are among a number of potent DDK inhibitors with low nanomolar IC50 values against the purified kinase. Although XL413 is highly selective for DDK, its activity has not been extensively characterized on cell lines. We measured anti-proliferative and apoptotic effects of XL413 on a panel of tumor cell lines compared to PHA-767491, whose activity is well characterized. Both compounds were effective biochemical DDK inhibitors but surprisingly, their activities in cell lines were highly divergent. Unlike PHA-767491, XL413 had significant anti-proliferative activity against only one of the ten cell lines tested. Since XL413 did not effectively inhibit DDK in multiple cell lines, this compound likely has limited bioavailability. To identify potential leads for additional DDK inhibitors, we also tested the cross-reactivity of ∼400 known kinase inhibitors against DDK using a DDK thermal stability shift assay (TSA. We identified 11 compounds that significantly stabilized DDK. Several inhibited DDK with comparable potency to PHA-767491, including Chk1 and PKR kinase inhibitors, but had divergent chemical scaffolds from known DDK inhibitors. Taken together, these data show that several well-known kinase inhibitors cross-react with DDK and also highlight the opportunity to design additional specific, biologically active DDK inhibitors for use as chemotherapeutic agents.

  2. Structure-based lead discovery for protein kinase C zeta inhibitor design by exploiting kinase-inhibitor complex crystal structure data and potential therapeutics for preterm labour.

    Science.gov (United States)

    Shao, Qing-Chun; Zhang, Cui-Juan; Li, Jie

    2014-10-14

    The protein kinase C (PKC) is a family of serine/threonine kinases with a broad range of cellular targets. Members of the PKC family participate at the diverse biological events involved in cellular proliferation, differentiation and survival. The PKC isoform zeta (PKCζ) is an atypical member that has recently been found to play an essential role in promoting human uterine contractility and thus been raised as a new target for treating preterm labour and other tocolytic diseases. In this study, an integrative protocol was described to graft hundreds of inhibitor ligands from their complex crystal structures with cognate kinases into the active pocket of PKCζ and, based on the modeled structures, to evaluate the binding strength of these inhibitors to the non-cognate PKCζ receptor by using a consensus scoring strategy. A total of 32 inhibitors with top score were compiled, and eight out of them were tested for inhibitory potency against PKCζ. Consequently, five compounds, i.e. CDK6 inhibitor fisetin, PIM1 inhibitor myricetin, CDK9 inhibitor flavopiridol and PknB inhibitor mitoxantrone as well as the promiscuous kinase inhibitor staurosporine showed high or moderate inhibitory activity on PKCζ, with IC50 values of 58 ± 9, 1.7 ± 0.4, 108 ± 17, 280 ± 47 and 0.019 ± 0.004 μM, respectively, while other three compounds, including two marketed drugs dasatinib and sunitinib as well as the Rho inhibitor fasudil, have not been detected to possess observable activity. Next, based on the modeled structure data we modified three flavonoid kinase inhibitors, i.e. fisetin, myricetin and flavopiridol, to generate a number of more potential molecular entities, two of which were found to have a moderately improved activity as compared to their parent compounds.

  3. Petrographic atlas characterisation of aggregates regarding potential reactivity to alkalis : RILEM TC 219-ACS recommended guidance AAR-1.2, for use with the RILEM AAR-1.1 petrographic examination method

    CERN Document Server

    Ribeiro, Maria; Broekmans, Maarten; Sims, Ian

    2016-01-01

    This RILEM AAR 1.2 Atlas is complementary to the petrographic method described in RILEM AAR 1.1. It is designed and intended to assist in the identification of alkali-reactive rock types in concrete aggregate by thin-section petrography. Additional issues include: • optical thin-section petrography conforming to RILEM AAR 1.1 is considered the prime assessment method for aggregate materials, being effective regarding cost and time. Unequivocal identification of minerals in very-fine grained rock types may however require use of supplementary methods. • the atlas adheres to internationally adopted schemes for rock classification and nomenclature, as recommended in AAR 1.1. Thus, rock types are classified as igneous, sedimentary or metamorphic based upon mineral content, microstructure and texture/fabric. • in addition, the atlas identifies known alkali-reactive silica types in each rock type presented. It also identifies consistent coincidence between certain lithologies and silica types; however, it ref...

  4. u4 fourth generation quark search with ATLAS detector at LHC

    International Nuclear Information System (INIS)

    The Standard Model describes the particle physics world and all measurements confirm its validity. However some problems are not solved by this model and numerous extensions of this model have been proposed. One of them postulate the existence of a fourth family of fermions in addition to the three standard families forming the building block of the Standard Model. This study, made in the ATLAS experiment at LHC, describes some methods which may permit to discover a fourth generation of up quark u4 produced in pair and that decays in a semi-leptonic way (u4u4-bar → W b W b-bar → lνb jjb-bar). Jet energy scale and the jet energy resolution measurement are primarily presented because of their interest in this precise measurement. A method to discover the u4 quark and the evaluation of the discovery potential are then presented in details. Finally, a measurement of the mass of this quark is realized assuming the fact that it has been discovered. This analysis shows that the discovery of u4 is reasonably possible for one year long data gathering at low luminosity and even for 1 fb-1 if its mass is below 400 GeV

  5. Reliable knowledge discovery

    CERN Document Server

    Dai, Honghua; Smirnov, Evgueni

    2012-01-01

    Reliable Knowledge Discovery focuses on theory, methods, and techniques for RKDD, a new sub-field of KDD. It studies the theory and methods to assure the reliability and trustworthiness of discovered knowledge and to maintain the stability and consistency of knowledge discovery processes. RKDD has a broad spectrum of applications, especially in critical domains like medicine, finance, and military. Reliable Knowledge Discovery also presents methods and techniques for designing robust knowledge-discovery processes. Approaches to assessing the reliability of the discovered knowledge are introduc

  6. National Atlas of Arctic: structure and creation approaches

    Directory of Open Access Journals (Sweden)

    N. S. Kasimov

    2015-01-01

    . Touristic maps will serve as guides for the Arctic with its bio-landscape and cultural diversity. Content of the Atlas should meet requirements of education standard in the field of geography. Ten sections are proposed for this version of the Atlas: introductory, geological structure, relief and resources, climate, permafrost and glaciers, land waters, seas of the Russian part of the Arctic, its flora and fauna, soils, population and economics, and conclusion Scientific and social results of the Atlas publication together with editorial and advertizing effects are demonstrated. Proposals for a format, scales of maps and type of edition are given, and potential participants of this project are indicated. 

  7. ATLAS and LHC computing on CRAY

    CERN Document Server

    Haug, Sigve; The ATLAS collaboration

    2016-01-01

    Access and exploitation of large scale computing resources, such as those offered by general purpose HPC centres, is one import measure for ATLAS and the other Large Hadron Collider experiments in order to meet the challenge posed by the full exploitation of the future data within the constraints of flat budgets. We report on the effort moving the Swiss WLCG T2 computing, serving ATLAS, CMS and LHCb from a dedicated cluster to the large CRAY systems at the Swiss National Supercomputing Centre CSCS. These systems do not only offer very efficient hardware, cooling and highly competent operators, but also have large backfill potentials due to size and multidisciplinary usage and potential gains due to economy at scale. Technical solutions, performance, expected return and future plans are discussed.

  8. Distributed computing operations in the German ATLAS cloud

    Energy Technology Data Exchange (ETDEWEB)

    Boehler, Michael; Gamel, Anton; Sundermann, Jan Erik [Universitaet Freiburg, Freiburg im Breisgau (Germany); Petzold, Andreas [KIT, Karlsruhe (Germany); Kawamura, Gen [Universitaet Mainz (Germany); Leffhalm, Kai [DESY (Germany); Sandhoff, Marisa; Harenberg, Torsten [Bergische Universitaet Wuppertal (Germany); Walker, Rod; Duckeck, Guenter [LMU Muenchen (Germany)

    2013-07-01

    Before announcing the discovery of a Higgs-like boson at the 4th of July 2012 a huge amount of data had to be distributed around the world and analysed. Moreover, to have well optimised analyses with solid background estimates, Monte Carlo simulated event samples needed to be generated. All of this, data distribution, Monte Carlo production, and also data reprocessing, is performed by the Worldwide LHC Computing Grid. The ATLAS grid computing resources in Austria, the Czech Republic, Germany, Poland, and Switzerland are organized in the GridKa cloud which is one out of 10 ATLAS computing clouds. It consists of the Tier-1 centre at KIT in Karlsruhe which serves as a hub for data management and stores raw ATLAS data and the Tier-2 centres that provide the resources for user analysis and Monte Carlo samples production. This talk gives an overview of the ATLAS grid computing operations in 2012 focusing on the performance and experiences at both the Tier-1 and Tier-2 centres and it summarises the prospects and requirements for grid computing during and after the long shut-down of the LHC in 2013/2014.

  9. Distributed computing operations in the German ATLAS cloud

    International Nuclear Information System (INIS)

    Before announcing the discovery of a Higgs-like boson at the 4th of July 2012 a huge amount of data had to be distributed around the world and analysed. Moreover, to have well optimised analyses with solid background estimates, Monte Carlo simulated event samples needed to be generated. All of this, data distribution, Monte Carlo production, and also data reprocessing, is performed by the Worldwide LHC Computing Grid. The ATLAS grid computing resources in Austria, the Czech Republic, Germany, Poland, and Switzerland are organized in the GridKa cloud which is one out of 10 ATLAS computing clouds. It consists of the Tier-1 centre at KIT in Karlsruhe which serves as a hub for data management and stores raw ATLAS data and the Tier-2 centres that provide the resources for user analysis and Monte Carlo samples production. This talk gives an overview of the ATLAS grid computing operations in 2012 focusing on the performance and experiences at both the Tier-1 and Tier-2 centres and it summarises the prospects and requirements for grid computing during and after the long shut-down of the LHC in 2013/2014.

  10. An anatomic gene expression atlas of the adult mouse brain.

    Science.gov (United States)

    Ng, Lydia; Bernard, Amy; Lau, Chris; Overly, Caroline C; Dong, Hong-Wei; Kuan, Chihchau; Pathak, Sayan; Sunkin, Susan M; Dang, Chinh; Bohland, Jason W; Bokil, Hemant; Mitra, Partha P; Puelles, Luis; Hohmann, John; Anderson, David J; Lein, Ed S; Jones, Allan R; Hawrylycz, Michael

    2009-03-01

    Studying gene expression provides a powerful means of understanding structure-function relationships in the nervous system. The availability of genome-scale in situ hybridization datasets enables new possibilities for understanding brain organization based on gene expression patterns. The Anatomic Gene Expression Atlas (AGEA) is a new relational atlas revealing the genetic architecture of the adult C57Bl/6J mouse brain based on spatial correlations across expression data for thousands of genes in the Allen Brain Atlas (ABA). The AGEA includes three discovery tools for examining neuroanatomical relationships and boundaries: (1) three-dimensional expression-based correlation maps, (2) a hierarchical transcriptome-based parcellation of the brain and (3) a facility to retrieve from the ABA specific genes showing enriched expression in local correlated domains. The utility of this atlas is illustrated by analysis of genetic organization in the thalamus, striatum and cerebral cortex. The AGEA is a publicly accessible online computational tool integrated with the ABA (http://mouse.brain-map.org/agea). PMID:19219037

  11. Distributed Data Analysis in ATLAS

    CERN Document Server

    Nilsson, P

    2009-01-01

    Data analysis using grid resources is one of the fundamental challenges to be addressed before the start of LHC data taking. The ATLAS detector will produce petabytes of data per year, and roughly one thousand users will need to run physics analyses on this data. Appropriate user interfaces and helper applications have been made available to ensure that the grid resources can be used without requiring expertise in grid technology. These tools enlarge the number of grid users from a few production administrators to potentially all participating physicists. ATLAS makes use of three grid infrastructures for the distributed analysis: the EGEE sites, the Open Science Grid, and NorduGrid. These grids are managed by the gLite workload management system, the PanDA workload management system, and ARC middleware; many sites can be accessed via both the gLite WMS and PanDA. Users can choose between two front-end tools to access the distributed resources. Ganga is a tool co-developed with LHCb to provide a common interfa...

  12. Distributed Data Analysis in ATLAS

    CERN Document Server

    Nilsson, P; The ATLAS collaboration

    2012-01-01

    Data analysis using grid resources is one of the fundamental challenges to be addressed before the start of LHC data taking. The ATLAS detector will produce petabytes of data per year, and roughly one thousand users will need to run physics analyses on this data. Appropriate user interfaces and helper applications have been made available to ensure that the grid resources can be used without requiring expertise in grid technology. These tools enlarge the number of grid users from a few production administrators to potentially all participating physicists. ATLAS makes use of three grid infrastructures for the distributed analysis: the EGEE sites, the Open Science Grid, and NorduGrid. These grids are managed by the gLite workload management system, the PanDA workload management system, and ARC middleware; many sites can be accessed via both the gLite WMS and PanDA. Users can choose between two front-end tools to access the distributed resources. Ganga is a tool co-developed with LHCb to provide a common interfa...

  13. The ATLAS Detector Safety System

    CERN Multimedia

    Helfried Burckhart; Kathy Pommes; Heidi Sandaker

    The ATLAS Detector Safety System (DSS) has the mandate to put the detector in a safe state in case an abnormal situation arises which could be potentially dangerous for the detector. It covers the CERN alarm severity levels 1 and 2, which address serious risks for the equipment. The highest level 3, which also includes danger for persons, is the responsibility of the CERN-wide system CSAM, which always triggers an intervention by the CERN fire brigade. DSS works independently from and hence complements the Detector Control System, which is the tool to operate the experiment. The DSS is organized in a Front- End (FE), which fulfills autonomously the safety functions and a Back-End (BE) for interaction and configuration. The overall layout is shown in the picture below. ATLAS DSS configuration The FE implementation is based on a redundant Programmable Logical Crate (PLC) system which is used also in industry for such safety applications. Each of the two PLCs alone, one located underground and one at the s...

  14. Higgs Boson Physics at ATLAS

    CERN Document Server

    StDenis, R; The ATLAS collaboration

    2014-01-01

    The discovery of a new boson with the ATLAS detector at the LHC proton-proton collider is confirmed using the full data set collected at centre-of-mass energies of 7 and 8 TeV. The spin and parity properties of the boson are consistent with that of a scalar particle with positive parity. Comparison of the $J^{P}=0^+$ hypothesis to alternatives $J^{P} = 0^-,1^{+},1^-,2^+$ result in exclusion of these other choices at 97.8\\%, 99.97\\%, 99.7\\%, and 99.3\\% CL. The Higgs-boson Mass is $m_H = 125.5 \\pm 0.2 {\\rm (stat.)} ^{+0.5}_{-0.5} {\\rm (syst.)}$ \\GeV. Evidence for production of the Higgs boson by vector boson fusion is obtained in a model-independent approach by comparing the signal strengths $\\mu$ of vector boson fusion and production associated with a vector boson to to that for gluon fusion including associated production of top quark pairs: $\\mu_{\\rm VBF+VH}/\\mu_{\\rm ggF+ttH}= 1.4 ^{+0.4}_{-0.3} \\rm{(stat.)} ^{+0.6}_{-0.4} \\rm{(syst.)}$ which is 3.3 Gaussian standard deviations from zero.

  15. Decades of Discovery

    Science.gov (United States)

    2011-06-01

    For the past two-and-a-half decades, the Office of Science at the U.S. Department of Energy has been at the forefront of scientific discovery. Over 100 important discoveries supported by the Office of Science are represented in this document.

  16. Academic Drug Discovery Centres

    DEFF Research Database (Denmark)

    Kirkegaard, Henriette Schultz; Valentin, Finn

    2014-01-01

    Academic drug discovery centres (ADDCs) are seen as one of the solutions to fill the innovation gap in early drug discovery, which has proven challenging for previous organisational models. Prior studies of ADDCs have identified the need to analyse them from the angle of their economic...

  17. Service discovery at home

    NARCIS (Netherlands)

    Sundramoorthy, Vasughi; Scholten, Hans; Jansen, Pierre; Hartel, Pieter

    2003-01-01

    Service discovery is a fairly new field that kicked off since the advent of ubiquitous computing and has been found essential in the making of intelligent networks by implementing automated discovery and remote control between devices. This paper provides an overview and comparison of several promin

  18. ATLAS: Exceeding all expectations

    CERN Multimedia

    CERN Bulletin

    2010-01-01

    “One year ago it would have been impossible for us to guess that the machine and the experiments could achieve so much so quickly”, says Fabiola Gianotti, ATLAS spokesperson. The whole chain – from collision to data analysis – has worked remarkably well in ATLAS.   The first LHC proton run undoubtedly exceeded expectations for the ATLAS experiment. “ATLAS has worked very well since the beginning. Its overall data-taking efficiency is greater than 90%”, says Fabiola Gianotti. “The quality and maturity of the reconstruction and simulation software turned out to be better than we expected for this initial stage of the experiment. The Grid is a great success, and right from the beginning it has allowed members of the collaboration all over the world to participate in the data analysis in an effective and timely manner, and to deliver physics results very quickly”. In just a few months of data taking, ATLAS has observed t...

  19. OCCIPITALIZATION OF ATLAS

    Directory of Open Access Journals (Sweden)

    Sween Walia

    2014-12-01

    Full Text Available Occipitalization of atlas is an osseous anomaly of the craniovertebral junction which occurs at the base of the skull in the region of the foramen magnum. The knowledge of such a fusion is important because skeletal abnormalities at the craniocervical junction may result in sudden death. During bone cleaning procedure and routine undergraduate osteology teaching, three skulls with Occipitalization of atlas were encountered in the department of Anatomy at MMIMSR, Mullana, India. In one skull, both anterior and posterior arch were completely fused with occipital bone while the transverse process on the right side was not fused whereas left transverse process was fused with occipital bone. Both anterior and posterior arch were completely fused whereas transverse process on both sides were not fused in other skull. In another skull, partial and asymmetrical Occipitalization of atlas vertebra with occipital bone was found with bifid posterior arch of atlas at the level of posterior tubercle. Anterior arch was completely fused with basilar part of occipital bone but both the transverse processes were not fused. Reduced diameter of foramen magnum due to the atlanto-occipital fusion might cause neurological complications due to compression of spinal cord or medulla oblongata, vertebral vessels, 1st cervical nerve, thus, knowledge of occipitalization of the atlas may be of substantial importance to orthopaedicians, neurosurgeons, physicians and radiologists dealing with abnormalities of the cervical spine.

  20. ATLAS Review Office

    CERN Multimedia

    Szeless, B

    The ATLAS internal reviews, be it the mandatory Production Readiness Reviews, the now newly installed Production Advancement Reviews, or the more and more requested different Design Reviews, have become a part of our ATLAS culture over the past years. The Activity Systems Status Overviews are, for the time being, a one in time event and should be held for each system as soon as possible to have some meaning. There seems to a consensus that the reviews have become a useful project tool for the ATLAS management but even more so for the sub-systems themselves making achievements as well as possible shortcomings visible. One other recognized byproduct is the increasing cross talk between the systems, a very important ingredient to make profit all the systems from the large collective knowledge we dispose of in ATLAS. In the last two months, the first two PARs were organized for the MDT End Caps and the TRT Barrel Modules, both part of the US contribution to the ATLAS Project. Furthermore several different design...

  1. Distributed analysis in ATLAS

    Science.gov (United States)

    Dewhurst, A.; Legger, F.

    2015-12-01

    The ATLAS experiment accumulated more than 140 PB of data during the first run of the Large Hadron Collider (LHC) at CERN. The analysis of such an amount of data is a challenging task for the distributed physics community. The Distributed Analysis (DA) system of the ATLAS experiment is an established and stable component of the ATLAS distributed computing operations. About half a million user jobs are running daily on DA resources, submitted by more than 1500 ATLAS physicists. The reliability of the DA system during the first run of the LHC and the following shutdown period has been high thanks to the continuous automatic validation of the distributed analysis sites and the user support provided by a dedicated team of expert shifters. During the LHC shutdown, the ATLAS computing model has undergone several changes to improve the analysis workflows, including the re-design of the production system, a new analysis data format and event model, and the development of common reduction and analysis frameworks. We report on the impact such changes have on the DA infrastructure, describe the new DA components, and include recent performance measurements.

  2. Distributed analysis in ATLAS

    CERN Document Server

    Legger, Federica; The ATLAS collaboration

    2015-01-01

    The ATLAS experiment accumulated more than 140 PB of data during the first run of the Large Hadron Collider (LHC) at CERN. The analysis of such an amount of data for the distributed physics community is a challenging task. The Distributed Analysis (DA) system of the ATLAS experiment is an established and stable component of the ATLAS distributed computing operations. About half a million user jobs are daily running on DA resources, submitted by more than 1500 ATLAS physicists. The reliability of the DA system during the first run of the LHC and the following shutdown period has been high thanks to the continuous automatic validation of the distributed analysis sites and the user support provided by a dedicated team of expert shifters. During the LHC shutdown, the ATLAS computing model has undergone several changes to improve the analysis workflows, including the re-design of the production system, a new analysis data format and event model, and the development of common reduction and analysis frameworks. We r...

  3. Search for a Higgs boson in fermion modes using the ATLAS detector.

    CERN Document Server

    Aben, RZ; The ATLAS collaboration

    2013-01-01

    Since the discovery of a Higgs-like boson by the ATLAS and CMS experiments at the LHC, the emphasis has shifted towards measurements of its properties in order to determine whether the new particle is the Standard Model (SM) Higgs boson, or something else. Of particular importance is the direct observation of the coupling of the Higgs boson to fermions. In this presentation a comprehensive review of ATLAS results in the search for the Higgs boson in the main fermion decay (bb and tautau) channels and in various production modes (VBF, VH, ttH, and gluon fusion) will be given.

  4. Search for the Higgs boson in VH(bb) channel using the ATLAS detector

    CERN Document Server

    Francavilla, P; The ATLAS collaboration

    2014-01-01

    Since the discovery of a Higgs boson by the ATLAS and CMS experiments at the LHC, the emphasis has shifted towards measurements of its properties and the search for less sensitive channels in order to determine whether the new particle is the Standard Model (SM) Higgs boson. Of particular importance is the direct observation of the coupling of the Higgs boson to b-quarks. In this talk a review of ATLAS results in the search for the Higgs boson in the VH production mode with the Higgs decaying to a b-quark pair decay will be given.

  5. Search for the Higgs boson in $\\tau^+\\tau^-$ channel using the ATLAS detector

    CERN Document Server

    O'Neil, D C; The ATLAS collaboration

    2013-01-01

    Since the discovery of a Higgs-­like boson by the ATLAS and CMS experiments at the LHC, the emphasis has shifted towards measurements of its properties and the search for the search in the less sensitive channels in order to determine whether the new particle is the Standard Model (SM) Higgs boson. Of particular importance is the direct observation of the coupling of the Higgs boson to leptons. In this presentation a comprehensive review of ATLAS results in the search for the Higgs boson in the tau-­tau decay channel and in various production modes (VBF, VH, and gluon fusion) will be given.

  6. Search for the Higgs boson in fermionic channels using the ATLAS detector

    CERN Document Server

    Hanagaki, K; The ATLAS collaboration

    2013-01-01

    Since the discovery of a Higgs-like boson by the ATLAS and CMS experiments at the LHC, the emphasis has shifted towards measurements of its properties and the search in the less sensitive channels in order to determine whether the new particle is the Standard Model (SM) Higgs boson. Of particular importance is the direct observation of the coupling of the Higgs boson to tau-leptons, b-quarks and the top-quark. In this presentation a comprehensive review of ATLAS results in the search for the Higgs boson in tau-leptons, b-quark pair decay channel and in the VH and ttH will be given.

  7. Search for the Higgs boson in fermionic channels using the ATLAS detector

    CERN Document Server

    Dell'Asta, L; The ATLAS collaboration

    2014-01-01

    Since the discovery of a Higgs-like boson by the ATLAS and CMS experiments at the LHC, the emphasis has shifted towards measurements of its properties and the search in the less sensitive channels in order to determine whether the new particle is the Standard Model (SM) Higgs boson. Of particular importance is the direct observation of the coupling of the Higgs boson to fermions. In this presentation a review of ATLAS results in the search for the Higgs boson in muon, tau-lepton, b-quark pair decay channels will be given.

  8. On the Gaia exoplanet discovery potential

    Directory of Open Access Journals (Sweden)

    Sozzetti A.

    2013-04-01

    Full Text Available In its all-sky astrometric survey, Gaia will be sensitive to giant planets orbiting within a few AUs of hundreds of thousands of bright main-sequence stars within ≈ 200 pc. The impact of Gaia observations in the astrophysics of planetary systems cannot be underestimated (e.g., Casertano et al. 2008, particularly if seen in synergy with other techniques for planet detection and characterization (e.g., Sozzetti 2011. I will briefly review the mission status and discuss relevant technical issues associated with the precise and accurate determination of Gaia astrometric orbits of planetary systems. I will then highlight some of the important synergies between Gaia high-precision astrometry and other ongoing and planned, indirect and direct planet-finding and characterization programs, both from the ground and in space, and over a broad range of wavelengths, and provide quantitative examples of such synergies using the sample of nearest stars to the Sun as a proxy.

  9. Measurement of the production cross-section of top quark pairs in the lepton+jets channel at D0 and ATLAS, and interpretation in terms of charged Higgs boson in ATLAS; Mesure de la section efficace de production de quarks top en paires dans le canal lepton+jets a D0 et a ATLAS et interpretation en terme de boson de Higgs charge dans ATLAS

    Energy Technology Data Exchange (ETDEWEB)

    Chevallier, F

    2007-05-15

    One of the main challenges of the current and future colliders TeVatron and LHC is the discovery of physics beyond the Standard Model. This goal may be accessible through precision measurements in the top quark sector. Deviations from theoretical predictions may bring to light the first indirect signs of new physics. The work exposed in this thesis deals with the production cross-section of top quark pairs via the strong interaction, within both D0 and ATLAS collaborations. Firstly, I have worked at D0 on the improvement of the reconstruction of soft electrons, in order to tag b-jets produced in top-anti top quarks events. Then I focused myself on the measurement of the top quark pair production cross-section with 420 pb{sup -1} of D0 data. The measured cross-section is in agreement with the Standard Model expectations. In the ATLAS experiment, I tried to develop a procedure in order to select top quark pair events, using the knowledge and the techniques from the D0 experiment. This work also high-lighted the main systematic sources that can affect the sensitivity of the measurement. After one year of data taking at low luminosity, this preliminary analysis obtains a sensitivity at a few percent level, leading to a good discovery potential of new physic signs, like charged Higgs bosons. These new particles appear in non minimal standard models, and modify the phenomenology of top pair events. This new analysis has shown a good sensitivity for some regions of the parameter space. (author)

  10. ATLAS production system

    CERN Document Server

    Borodin, Mikhail; The ATLAS collaboration; De, Kaushik; Klimentov, Alexei; Golubkov, Dmitry; Maeno, Tadashi; Mashinistov, Ruslan; Wenaus, Torre; Padolski, Siarhei

    2016-01-01

    The second generation of the ATLAS production system called ProdSys2 is a distributed workload manager which used by thousands of physicists to analyze the data remotely, with the volume of processed data is beyond the exabyte scale, across a more than hundred heterogeneous sites. It achieves high utilization by combining dynamic job definition based on many criterias, such as input and output size, memory requirements and CPU consumption with manageable scheduling policies and by supporting different kind of computational resources, such as GRID, clouds, supercomputers and volunteering computers. Besides jobs definition Production System also includes flexible web user interface, which implements user-friendly environment for main ATLAS workflows, e.g. simple way of combining different data flows, and real-time monitoring, optimised for using with huge amount of information to present. We present an overview of the ATLAS Production System major components: job and task definition, workflow manager web user i...

  11. Two ATLAS suppliers honoured

    CERN Multimedia

    2007-01-01

    The ATLAS experiment has recognised the outstanding contribution of two firms to the pixel detector. Recipients of the supplier award with Peter Jenni, ATLAS spokesperson, and Maximilian Metzger, CERN Secretary-General.At a ceremony held at CERN on 28 November, the ATLAS collaboration presented awards to two of its suppliers that had produced sensor wafers for the pixel detector. The CiS Institut für Mikrosensorik of Erfurt in Germany has supplied 655 sensor wafers containing a total of 1652 sensor tiles and the firm ON Semiconductor has supplied 515 sensor wafers (1177 sensor tiles) from its foundry at Roznov in the Czech Republic. Both firms have successfully met the very demanding requirements. ATLAS’s huge pixel detector is very complicated, requiring expertise in highly specialised integrated microelectronics and precision mechanics. Pixel detector project leader Kevin Einsweiler admits that when the project was first propo...

  12. ATLAS rewards industry

    CERN Multimedia

    2006-01-01

    Showing excellence in mechanics, electronics and cryogenics, three industries are honoured for their contributions to the ATLAS experiment. Representatives of the three award-wining companies after the ceremony. For contributing vital pieces to the ATLAS puzzle, three industries were recognized on Friday 5 May during a supplier awards ceremony. After a welcome and overview of the ATLAS experiment by spokesperson Peter Jenni, CERN Secretary-General Maximilian Metzger stressed the importance of industry to CERN's scientific goals. Close interaction with CERN was a key factor in the selection of each rewarded company, in addition to the high-quality products they delivered to the experiment. Alu Menziken Industrie AG, of Switzerland, was honoured for the production of 380,000 aluminium tubes for the Monitored Drift Tube Chambers (MDT). As Giora Mikenberg, the Muon System Project Leader stressed, the aluminium tubes were delivered on time with an extraordinary quality and precision. Between October 2000 and Jan...

  13. ATLAS TDAQ System Administration:

    CERN Document Server

    Lee, Christopher Jon; The ATLAS collaboration; Bogdanchikov, Alexander; Ballestrero, Sergio; Contescu, Alexandru Cristian; Dubrov, Sergei; Fazio, Daniel; Korol, Aleksandr; Scannicchio, Diana; Twomey, Matthew Shaun; Voronkov, Artem

    2015-01-01

    The ATLAS Trigger and Data Acquisition (TDAQ) system is responsible for the online processing of live data, streaming from the ATLAS experiment at the Large Hadron Collider (LHC) at CERN. The online farm is composed of ̃3000 servers, processing the data readout from ̃100 million detector channels through multiple trigger levels. During the two years of the first Long Shutdown (LS1) there has been a tremendous amount of work done by the ATLAS TDAQ System Administrators, implementing numerous new software applications, upgrading the OS and the hardware, changing some design philosophies and exploiting the High Level Trigger farm with different purposes. During the data taking only critical security updates are applied and broken hardware is replaced to ensure a stable operational environment. The LS1 provided an excellent opportunity to look into new technologies and applications that would help to improve and streamline the daily tasks of not only the System Administrators, but also of the scientists who wil...

  14. Discovery Mondays - The detectors: tracking particles

    CERN Multimedia

    2005-01-01

    View of a module from the LHCb vertex detector, which will be presented at the next Discovery Monday. How do you observe the invisible? In order to deepen still further our knowledge of the infinitely small, physicists accelerate beams of particles and generate collisions between them at extraordinary energies. The collisions give birth to showers of new particles. What are they? In order to find out, physicists slip into the role of detectives thanks to the detectors. At the next Discovery Monday you will find out about the different methods used at CERN to detect particles. A cloud chamber will allow you to see the tracks of cosmic particles live. You will also be given the chance to see real modules for the ATLAS and for the LHCb experiments. Strange materials will be on hand, such as crystals that are heavier than iron and yet as transparent as glass... Come to the Microcosm and become a top detective yourself! This event will take place in French. Join us at the Microcosm (Reception Building 33, M...

  15. EnviroAtlas - Durham, NC - 15m Riparian Buffer Forest Cover

    Data.gov (United States)

    U.S. Environmental Protection Agency — This EnviroAtlas dataset describes the percentage of a 15-m riparian buffer that is forested. There is a potential for decreased water quality in areas where the...

  16. EnviroAtlas - Durham, NC - 15m Riparian Buffer Vegetated Cover

    Data.gov (United States)

    U.S. Environmental Protection Agency — This EnviroAtlas dataset describes the percentage of a 15-m riparian buffer that is vegetated. There is a potential for decreased water quality in areas where the...

  17. EnviroAtlas - New Bedford, MA - 51m Riparian Buffer Forest Cover

    Data.gov (United States)

    U.S. Environmental Protection Agency — This EnviroAtlas dataset describes the percentage of a 51-m riparian buffer that is forested. There is a potential for decreased water quality in areas where the...

  18. EnviroAtlas - Durham, NC - 51m Riparian Buffer Vegetated Cover

    Data.gov (United States)

    U.S. Environmental Protection Agency — This EnviroAtlas dataset describes the percentage of a 51-m riparian buffer that is vegetated. There is a potential for decreased water quality in areas where the...

  19. EnviroAtlas - Durham, NC - 51m Riparian Buffer Forest Cover

    Data.gov (United States)

    U.S. Environmental Protection Agency — This EnviroAtlas dataset describes the percentage of a 51-m riparian buffer that is forested. There is a potential for decreased water quality in areas where the...

  20. EnviroAtlas - Portland, OR - 15m Riparian Buffer Forest Cover

    Data.gov (United States)

    U.S. Environmental Protection Agency — This EnviroAtlas dataset describes the percentage of a 15-m riparian buffer that is forested. There is a potential for decreased water quality in areas where the...

  1. EnviroAtlas - Portland, ME - 51m Riparian Buffer Vegetated Cover

    Data.gov (United States)

    U.S. Environmental Protection Agency — This EnviroAtlas dataset describes the percentage of a 51-m riparian buffer that is vegetated. There is a potential for decreased water quality in areas where the...

  2. EnviroAtlas - New Bedford, MA - 15m Riparian Buffer Vegetated Cover

    Data.gov (United States)

    U.S. Environmental Protection Agency — This EnviroAtlas dataset describes the percentage of a 15-m riparian buffer that is vegetated. There is a potential for decreased water quality in areas where the...

  3. EnviroAtlas - Tampa, FL - 51m Riparian Buffer Vegetated Cover

    Data.gov (United States)

    U.S. Environmental Protection Agency — This EnviroAtlas dataset describes the percentage of a 51-m riparian buffer that is vegetated. There is a potential for decreased water quality in areas where the...

  4. EnviroAtlas - Woodbine, IA - 15m Riparian Buffer Vegetated Cover

    Data.gov (United States)

    U.S. Environmental Protection Agency — This EnviroAtlas dataset describes the percentage of a 15-m riparian buffer that is vegetated. There is a potential for decreased water quality in areas where the...

  5. EnviroAtlas - Tampa, FL - 51m Riparian Buffer Forest Cover

    Data.gov (United States)

    U.S. Environmental Protection Agency — This EnviroAtlas dataset describes the percentage of a 51-m riparian buffer that is forested. There is a potential for decreased water quality in areas where the...

  6. EnviroAtlas - Paterson, NJ - 51m Riparian Buffer Forest Cover

    Data.gov (United States)

    U.S. Environmental Protection Agency — This EnviroAtlas dataset describes the percentage of a 51-m riparian buffer that is forested. There is a potential for decreased water quality in areas where the...

  7. EnviroAtlas - Paterson, NJ - 15m Riparian Buffer Vegetated Cover

    Data.gov (United States)

    U.S. Environmental Protection Agency — This EnviroAtlas dataset describes the percentage of a 15-m riparian buffer that is vegetated. There is a potential for decreased water quality in areas where the...

  8. EnviroAtlas - Portland, OR - 15m Riparian Buffer Vegetated Cover

    Data.gov (United States)

    U.S. Environmental Protection Agency — This EnviroAtlas dataset describes the percentage of a 15-m riparian buffer that is vegetated. There is a potential for decreased water quality in areas where the...

  9. EnviroAtlas - Paterson, NJ - 15m Riparian Buffer Forest Cover

    Data.gov (United States)

    U.S. Environmental Protection Agency — This EnviroAtlas dataset describes the percentage of a 15-m riparian buffer that is forested. There is a potential for decreased water quality in areas where the...

  10. EnviroAtlas - Portland, ME - 15m Riparian Buffer Vegetated Cover

    Data.gov (United States)

    U.S. Environmental Protection Agency — This EnviroAtlas dataset describes the percentage of a 15-m riparian buffer that is vegetated. There is a potential for decreased water quality in areas where the...

  11. EnviroAtlas - Woodbine, IA - 15m Riparian Buffer Forest Cover

    Data.gov (United States)

    U.S. Environmental Protection Agency — This EnviroAtlas dataset describes the percentage of a 15-m riparian buffer that is forested. There is a potential for decreased water quality in areas where the...

  12. EnviroAtlas - Pittsburgh, PA - 51m Riparian Buffer Forest Cover

    Data.gov (United States)

    U.S. Environmental Protection Agency — This EnviroAtlas dataset describes the percentage of a 51-m riparian buffer that is forested. There is a potential for decreased water quality in areas where the...

  13. EnviroAtlas - Woodbine, IA - 51m Riparian Buffer Vegetated Cover

    Data.gov (United States)

    U.S. Environmental Protection Agency — This EnviroAtlas dataset describes the percentage of a 51-m riparian buffer that is vegetated. There is a potential for decreased water quality in areas where the...

  14. EnviroAtlas - Portland, OR - 51m Riparian Buffer Vegetated Cover

    Data.gov (United States)

    U.S. Environmental Protection Agency — This EnviroAtlas dataset describes the percentage of a 51-m riparian buffer that is vegetated. There is a potential for decreased water quality in areas where the...

  15. EnviroAtlas - Paterson, NJ - 51m Riparian Buffer Vegetated Cover

    Data.gov (United States)

    U.S. Environmental Protection Agency — This EnviroAtlas dataset describes the percentage of a 51-m riparian buffer that is vegetated. There is a potential for decreased water quality in areas where the...

  16. EnviroAtlas - Green Bay, WI - 15m Riparian Buffer Vegetated Cover

    Data.gov (United States)

    U.S. Environmental Protection Agency — This EnviroAtlas dataset describes the percentage of a 15-m riparian buffer that is vegetated. There is a potential for decreased water quality in areas where the...

  17. EnviroAtlas - Portland, Maine - 51m Riparian Buffer Forest Cover

    Data.gov (United States)

    U.S. Environmental Protection Agency — This EnviroAtlas dataset describes the percentage of a 51-m riparian buffer that is forested. There is a potential for decreased water quality in areas where the...

  18. EnviroAtlas - Pittsburgh, PA - 15m Riparian Buffer Forest Cover

    Data.gov (United States)

    U.S. Environmental Protection Agency — This EnviroAtlas dataset describes the percentage of a 15-m riparian buffer that is forested. There is a potential for decreased water quality in areas where the...

  19. EnviroAtlas - Portland, OR - 51m Riparian Buffer Forest Cover

    Data.gov (United States)

    U.S. Environmental Protection Agency — This EnviroAtlas dataset describes the percentage of a 51-m riparian buffer that is forested. There is a potential for decreased water quality in areas where the...

  20. EnviroAtlas - Fresno, CA - 15m Riparian Buffer Forest Cover

    Data.gov (United States)

    U.S. Environmental Protection Agency — This EnviroAtlas dataset describes the percentage of a 15-m riparian buffer that is forested. There is a potential for decreased water quality in areas where the...

  1. EnviroAtlas - Milwaukee, WI - 15m Riparian Buffer Forest Cover

    Data.gov (United States)

    U.S. Environmental Protection Agency — This EnviroAtlas dataset describes the percentage of a 15-m riparian buffer that is forested. There is a potential for decreased water quality in areas where the...

  2. EnviroAtlas - Fresno, CA - 51m Riparian Buffer Forest Cover

    Data.gov (United States)

    U.S. Environmental Protection Agency — This EnviroAtlas dataset describes the percentage of a 51-m riparian buffer that is forested. There is a potential for decreased water quality in areas where the...

  3. EnviroAtlas - Pittsburgh, PA - 15m Riparian Buffer Vegetated Cover

    Data.gov (United States)

    U.S. Environmental Protection Agency — This EnviroAtlas dataset describes the percentage of a 15-m riparian buffer that is vegetated. There is a potential for decreased water quality in areas where the...

  4. EnviroAtlas - Tampa, FL - 15m Riparian Buffer Vegetated Cover

    Data.gov (United States)

    U.S. Environmental Protection Agency — This EnviroAtlas dataset describes the percentage of a 15-m riparian buffer that is vegetated. There is a potential for decreased water quality in areas where the...

  5. EnviroAtlas - Green Bay, WI - 51m Riparian Buffer Forest Cover

    Data.gov (United States)

    U.S. Environmental Protection Agency — This EnviroAtlas dataset describes the percentage of a 51-m riparian buffer that is forested. There is a potential for decreased water quality in areas where the...

  6. EnviroAtlas - Phoenix, AZ - 51m Riparian Buffer Vegetated Cover

    Data.gov (United States)

    U.S. Environmental Protection Agency — This EnviroAtlas dataset describes the percentage of a 51-m riparian buffer that is vegetated. There is a potential for decreased water quality in areas where the...

  7. EnviroAtlas - Phoenix, AZ - 15m Riparian Buffer Vegetated Cover

    Data.gov (United States)

    U.S. Environmental Protection Agency — This EnviroAtlas dataset describes the percentage of a 15-m riparian buffer that is vegetated. There is a potential for decreased water quality in areas where the...

  8. EnviroAtlas - Milwaukee, WI - 51m Riparian Buffer Vegetated Cover

    Data.gov (United States)

    U.S. Environmental Protection Agency — This EnviroAtlas dataset describes the percentage of a 51-m riparian buffer that is vegetated. There is a potential for decreased water quality in areas where the...

  9. EnviroAtlas - Green Bay, WI - 15m Riparian Buffer Forest Cover

    Data.gov (United States)

    U.S. Environmental Protection Agency — This EnviroAtlas dataset describes the percentage of a 15-m riparian buffer that is forested. There is a potential for decreased water quality in areas where the...

  10. EnviroAtlas - Portland, ME - 15m Riparian Buffer Forest Cover

    Data.gov (United States)

    U.S. Environmental Protection Agency — This EnviroAtlas dataset describes the percentage of a 15-m riparian buffer that is forested. There is a potential for decreased water quality in areas where the...

  11. EnviroAtlas - Green Bay, WI - 51m Riparian Buffer Vegetated Cover

    Data.gov (United States)

    U.S. Environmental Protection Agency — This EnviroAtlas dataset describes the percentage of a 51-m riparian buffer that is vegetated. There is a potential for decreased water quality in areas where the...

  12. EnviroAtlas - New Bedford, MA - 15m Riparian Buffer Forest Cover

    Data.gov (United States)

    U.S. Environmental Protection Agency — This EnviroAtlas dataset describes the percentage of a 15-m riparian buffer that is forested. There is a potential for decreased water quality in areas where the...

  13. EnviroAtlas - Milwaukee, WI - 51m Riparian Buffer Forest Cover

    Data.gov (United States)

    U.S. Environmental Protection Agency — This EnviroAtlas dataset describes the percentage of a 51-m riparian buffer that is forested. There is a potential for decreased water quality in areas where the...

  14. EnviroAtlas - Pittsburgh, PA - 51m Riparian Buffer Vegetated Cover

    Data.gov (United States)

    U.S. Environmental Protection Agency — This EnviroAtlas dataset describes the percentage of a 51-m riparian buffer that is vegetated. There is a potential for decreased water quality in areas where the...

  15. EnviroAtlas - Woodbine, Iowa - 51m Riparian Buffer Forest Cover

    Data.gov (United States)

    U.S. Environmental Protection Agency — This EnviroAtlas dataset describes the percentage of a 51-m riparian buffer that is forested. There is a potential for decreased water quality in areas where the...

  16. EnviroAtlas - Phoenix, AZ - 15m Riparian Buffer Forest Cover

    Data.gov (United States)

    U.S. Environmental Protection Agency — This EnviroAtlas dataset describes the percentage of a 15-m riparian buffer that is forested. There is a potential for decreased water quality in areas where the...

  17. EnviroAtlas - Tampa, FL - 15m Riparian Buffer Forest Cover

    Data.gov (United States)

    U.S. Environmental Protection Agency — This EnviroAtlas dataset describes the percentage of a 15-m riparian buffer that is forested. There is a potential for decreased water quality in areas where the...

  18. EnviroAtlas - Fresno, CA - 51m Riparian Buffer Vegetated Cover

    Data.gov (United States)

    U.S. Environmental Protection Agency — This EnviroAtlas dataset describes the percentage of a 51-m riparian buffer that is vegetated. There is a potential for decreased water quality in areas where the...

  19. EnviroAtlas - Fresno, CA - 15m Riparian Buffer Vegetated Cover

    Data.gov (United States)

    U.S. Environmental Protection Agency — This EnviroAtlas dataset describes the percentage of a 15-m riparian buffer that is vegetated. There is a potential for decreased water quality in areas where the...

  20. EnviroAtlas - Phoenix, AZ - 51m Riparian Buffer Forest Cover

    Data.gov (United States)

    U.S. Environmental Protection Agency — This EnviroAtlas dataset describes the percentage of a 51-m riparian buffer that is forested. There is a potential for decreased water quality in areas where the...

  1. EnviroAtlas - New Bedford, MA - 51m Riparian Buffer Vegetated Cover

    Data.gov (United States)

    U.S. Environmental Protection Agency — This EnviroAtlas dataset describes the percentage of a 51-m riparian buffer that is vegetated. There is a potential for decreased water quality in areas where the...

  2. EnviroAtlas - Milwaukee, WI - 15m Riparian Buffer Vegetated Cover

    Data.gov (United States)

    U.S. Environmental Protection Agency — This EnviroAtlas dataset describes the percentage of a 15-m riparian buffer that is vegetated. There is a potential for decreased water quality in areas where the...

  3. ATLAS EventIndex General Dataflow and Monitoring Infrastructure

    CERN Document Server

    Barberis, Dario; The ATLAS collaboration

    2016-01-01

    The ATLAS EventIndex has been running in production since mid-2015, reliably collecting information worldwide about all produced events and storing them in a central Hadoop infrastructure at CERN. A subset of this information is copied to an Oracle relational database for fast datasets discovery, event-picking, crosschecks with other ATLAS systems and checks for event duplication. The system design and its optimization is serving event picking from requests of a few events up to scales of tens of thousand of events, and in addition, data consistency checks are performed for large production campaigns. Detecting duplicate events with a scope of physics collections has recently arisen as an important use case. This paper describes the general architecture of the project and the data flow and operation issues, which are addressed by recent developments to improve the throughput of the overall system. In this direction, the data collection system is reducing the usage of the messaging infrastructure to overcome t...

  4. Review of Higgs results at LHC (ATLAS and CMS results)

    CERN Document Server

    Favareto, Andrea; The ATLAS collaboration

    2016-01-01

    The status of Higgs sector studies at the Large Hadron Collider from the ATLAS and CMS experiments is reviewed. The Run~1 legacy on Higgs boson discovery is presented: the combined data samples of the two experiments were used for the measurements of the Higgs boson mass and couplings; the CP and spin analysis done separately by the CMS and ATLAS experiments are also described and the searches for $H\\to b\\bar{b}$ decay channel are illustrated. Finally, a first look to Run~2 data with few searches for additional Higgs boson states beyond that of the Standard Model are presented. Emphasis is given to searches that include $b$-quarks in the final state, and profit from their presence. Presently no statistically significant deviations from the Standard Model predictions are observed.

  5. The ATLAS ITk Strip Detector. Status of R&D

    CERN Document Server

    Garcia-Argos, Carlos; The ATLAS collaboration

    2016-01-01

    While the LHC at CERN is ramping up luminosity after the discovery of the Higgs Boson in the ATLAS and CMS experiments in 2012, upgrades to the LHC and experiments are planned. The major upgrade is foreseen for 2024, with a roughly tenfold increase in luminosity, resulting in corresponding increases in particle rates and radiation doses. In ATLAS the entire Inner Detector will be replaced for Phase-2 running with an all-silicon system. This paper concentrates on the strip part. Its layout foresees low-mass and modular yet highly integrated double-sided structures for the barrel and forward region. The design features conceptually simple modules made from electronic hybrids glued directly onto the silicon. Modules will then be assembled on both sides of large carbon-core structures with integrated cooling and electrical services.

  6. ATLAS TV PROJECT

    CERN Multimedia

    2005-01-01

    CAMERA ON TOROID The ATLAS barrel toroid system consists of eight coils, each of axial length 25.3 m, assembled radially and symmetrically around the beam axis. The coils are of a flat racetrack type with two double-pancake windings made of 20.5 kA aluminium-stabilized niobium-titanium superconductor. The video is about the slow lowering of the toroid down to the cavern of ATLAS. It is very demanding task. The camera is placed on top of the toroid.

  7. ATLAS forward physics program

    CERN Document Server

    HELLER, M; The ATLAS collaboration

    2010-01-01

    The variety of forward detectors installed in the vicinity of the ATLAS experiment allows to look over a wide range of forward physics topics. They ensure a good information about rapidity gaps, and the installation of very forward detectors (ALFA and AFP) will allow to tag the leading proton(s) remaining from the different processes studied. Most of the studies have to be done at low luminosity to avoid pile-up, but the AFP project offers a really exiting future for the ATLAS forward physics program. We also present how these forward detectors can be used to measure the relative and absolute luminosity.

  8. The Herschel ATLAS

    CERN Document Server

    Eales, S; Clements, D; Cooray, A R; De Zotti, G; Dye, S; Ivison, R; Jarvis, M; Lagache, G; Maddox, S; Negrello, M; Serjeant, S; Thompson, M A; Van Kampen, E; Amblard, A; Andreani, P; Baes, M; Beelen, A; Bendo, G J; Benford, D; Bertoldi, F; Bock, J; Bonfield, D; Boselli, A; Bridge, C; Buat, V; Burgarella, D; Carlberg, R; Cava, A; Chanial, P; Charlot, S; Christopher, N; Coles, P; Cortese, L; Dariush, A; Da Cunha, E; Dalton, G; Danese, L; Dannerbauer, H; Driver, S; Dunlop, J; Fan, L; Farrah, D; Frayer, D; Frenk, C; Geach, J; Gardner, J; Gomez, H; Gonzalez-Nuevo, J; Gonzalez-Solares, E; Griffin, M; Hardcastle, M; Hatziminaoglou, E; Herranz, D; Hughes, D; Ibar, E; Jeong, Woong-Seob; Lacey, C; Lapi, A; Lee, M; Leeuw, L; Liske, J; Lopez-Caniego, M; Müller, T; Nandra, K; Panuzzo, P; Papageorgiou, A; Patanchon, G; Peacock, J; Pearson, C; Phillipps, S; Pohlen, M; Popescu, C; Rawlings, S; Rigby, E; Rigopoulou, M; Rodighiero, G; Sansom, A; Schulz, B; Scott, D; Smith, D J B; Sibthorpe, B; Smail, I; Stevens, J; Sutherland, W; Takeuchi, T; Tedds, J; Temi, P; Tuffs, R; Trichas, M; Vaccari, M; Valtchanov, I; Van der Werf, P; Verma, A; Vieria, J; Vlahakis, C; White, Glenn J

    2009-01-01

    The Herschel ATLAS is the largest open-time key project that will be carried out on the Herschel Space Observatory. It will survey 510 square degrees of the extragalactic sky, four times larger than all the other Herschel surveys combined, in five far-infrared and submillimetre bands. We describe the survey, the complementary multi-wavelength datasets that will be combined with the Herschel data, and the six major science programmes we are undertaking. Using new models based on a previous submillimetre survey of galaxies, we present predictions of the properties of the ATLAS sources in other wavebands.

  9. The Herschel ATLAS

    Science.gov (United States)

    Eales, S.; Dunne, L.; Clements, D.; Cooray, A.; De Zotti, G.; Dye, S.; Ivison, R.; Jarvis, M.; Lagache, G.; Maddox, S.; Negrello, M.; Serjeant, S.; Thompson, M. A.; Van Kampen, E.; Amblard, A.; Andreani, P.; Baes, M.; Beelen, A.; Bendo, G. J.; Bertoldi, F.; Benford, D.; Bock, J.

    2010-01-01

    The Herschel ATLAS is the largest open-time key project that will be carried out on the Herschel Space Observatory. It will survey 570 sq deg of the extragalactic sky, 4 times larger than all the other Herschel extragalactic surveys combined, in five far-infrared and submillimeter bands. We describe the survey, the complementary multiwavelength data sets that will be combined with the Herschel data, and the six major science programs we are undertaking. Using new models based on a previous submillimeter survey of galaxies, we present predictions of the properties of the ATLAS sources in other wave bands.

  10. The ATLAS Simulation Infrastructure

    CERN Document Server

    Aad, Georges; Abdallah, Jalal; Abdelalim, Ahmed Ali; Abdesselam, Abdelouahab; Abdinov, Ovsat; Abi, Babak; Abolins, Maris; Abramowicz, Halina; Abreu, Henso; Acharya, Bobby Samir; Adams, David; Addy, Tetteh; Adelman, Jahred; Adorisio, Cristina; Adragna, Paolo; Adye, Tim; Aefsky, Scott; Aguilar-Saavedra, Juan Antonio; Aharrouche, Mohamed; Ahlen, Steven; Ahles, Florian; Ahmad, Ashfaq; Ahmed, Hossain; Ahsan, Mahsana; Aielli, Giulio; Akdogan, Taylan; Åkesson, Torsten Paul Ake; Akimoto, Ginga; Akimov , Andrei; Aktas, Adil; Alam, Mohammad; Alam, Muhammad Aftab; Albrand, Solveig; Aleksa, Martin; Aleksandrov, Igor; Alexa, Calin; Alexander, Gideon; Alexandre, Gauthier; Alexopoulos, Theodoros; Alhroob, Muhammad; Aliev, Malik; Alimonti, Gianluca; Alison, John; Aliyev, Magsud; Allport, Phillip; Allwood-Spiers, Sarah; Almond, John; Aloisio, Alberto; Alon, Raz; Alonso, Alejandro; Alviggi, Mariagrazia; Amako, Katsuya; Amelung, Christoph; Amorim, Antonio; Amorós, Gabriel; Amram, Nir; Anastopoulos, Christos; Andeen, Timothy; Anders, Christoph Falk; Anderson, Kelby; Andreazza, Attilio; Andrei, George Victor; Anduaga, Xabier; Angerami, Aaron; Anghinolfi, Francis; Anjos, Nuno; Annovi, Alberto; Antonaki, Ariadni; Antonelli, Mario; Antonelli, Stefano; Antos, Jaroslav; Antunovic, Bijana; Anulli, Fabio; Aoun, Sahar; Arabidze, Giorgi; Aracena, Ignacio; Arai, Yasuo; Arce, Ayana; Archambault, John-Paul; Arfaoui, Samir; Arguin, Jean-Francois; Argyropoulos, Theodoros; Arik, Metin; Armbruster, Aaron James; Arnaez, Olivier; Arnault, Christian; Artamonov, Andrei; Arutinov, David; Asai, Makoto; Asai, Shoji; Silva, José; Asfandiyarov, Ruslan; Ask, Stefan; Åsman, Barbro; Asner, David; Asquith, Lily; Assamagan, Ketevi; Astbury, Alan; Astvatsatourov, Anatoli; Atoian, Grigor; Auerbach, Benjamin; Augsten, Kamil; Aurousseau, Mathieu; Austin, Nicholas; Avolio, Giuseppe; Avramidou, Rachel Maria; Axen, David; Ay, Cano; Azuelos, Georges; Azuma, Yuya; Baak, Max; Bach, Andre; Bachacou, Henri; Bachas, Konstantinos; Backes, Moritz; Badescu, Elisabeta; Bagnaia, Paolo; Bai, Yu; Bain, Travis; Baines, John; Baker, Mark; Baker, Oliver Keith; Baker, Sarah; Baltasar Dos Santos Pedrosa, Fernando; Banas, Elzbieta; Banerjee, Piyali; Banerjee, Swagato; Banfi, Danilo; Bangert, Andrea Michelle; Bansal, Vikas; Baranov, Sergey; Baranov, Sergei; Barashkou, Andrei; Barber, Tom; Barberio, Elisabetta Luigia; Barberis, Dario; Barbero, Marlon; Bardin, Dmitri; Barillari, Teresa; Barisonzi, Marcello; Barklow, Timothy; Barlow, Nick; Barnett, Bruce; Barnett, Michael; Baroncelli, Antonio; Barr, Alan; Barreiro, Fernando; Barreiro Guimarães da Costa, João; Barrillon, Pierre; Bartoldus, Rainer; Bartsch, Detlef; Bates, Richard; Batkova, Lucia; Batley, Richard; Battaglia, Andreas; Battistin, Michele; Bauer, Florian; Bawa, Harinder Singh; Bazalova, Magdalena; Beare, Brian; Beau, Tristan; Beauchemin, Pierre-Hugues; Beccherle, Roberto; Becerici, Neslihan; Bechtle, Philip; Beck, Graham; Beck, Hans Peter; Beckingham, Matthew; Becks, Karl-Heinz; Beddall, Ayda; Beddall, Andrew; Bednyakov, Vadim; Bee, Christopher; Begel, Michael; Behar Harpaz, Silvia; Behera, Prafulla; Beimforde, Michael; Belanger-Champagne, Camille; Bell, Paul; Bell, William; Bella, Gideon; Bellagamba, Lorenzo; Bellina, Francesco; Bellomo, Massimiliano; Belloni, Alberto; Belotskiy, Konstantin; Beltramello, Olga; Ben Ami, Sagi; Benary, Odette; Benchekroun, Driss; Bendel, Markus; Benedict, Brian Hugues; Benekos, Nektarios; Benhammou, Yan; Benincasa, Gianpaolo; Benjamin, Douglas; Benoit, Mathieu; Bensinger, James; Benslama, Kamal; Bentvelsen, Stan; Beretta, Matteo; Berge, David; Bergeaas Kuutmann, Elin; Berger, Nicolas; Berghaus, Frank; Berglund, Elina; Beringer, Jürg; Bernat, Pauline; Bernhard, Ralf; Bernius, Catrin; Berry, Tracey; Bertin, Antonio; Besana, Maria Ilaria; Besson, Nathalie; Bethke, Siegfried; Bianchi, Riccardo-Maria; Bianco, Michele; Biebel, Otmar; Biesiada, Jed; Biglietti, Michela; Bilokon, Halina; Bindi, Marcello; Binet, Sebastien; Bingul, Ahmet; Bini, Cesare; Biscarat, Catherine; Bitenc, Urban; Black, Kevin; Blair, Robert; Blanchard, Jean-Baptiste; Blanchot, Georges; Blocker, Craig; Blondel, Alain; Blum, Walter; Blumenschein, Ulrike; Bobbink, Gerjan; Bocci, Andrea; Boehler, Michael; Boek, Jennifer; Boelaert, Nele; Böser, Sebastian; Bogaerts, Joannes Andreas; Bogouch, Andrei; Bohm, Christian; Bohm, Jan; Boisvert, Veronique; Bold, Tomasz; Boldea, Venera; Bondarenko, Valery; Bondioli, Mario; Boonekamp, Maarten; Bordoni, Stefania; Borer, Claudia; Borisov, Anatoly; Borissov, Guennadi; Borjanovic, Iris; Borroni, Sara; Bos, Kors; Boscherini, Davide; Bosman, Martine; Boterenbrood, Hendrik; Bouchami, Jihene; Boudreau, Joseph; Bouhova-Thacker, Evelina Vassileva; Boulahouache, Chaouki; Bourdarios, Claire; Boveia, Antonio; Boyd, James; Boyko, Igor; Bozovic-Jelisavcic, Ivanka; Bracinik, Juraj; Braem, André; Branchini, Paolo; Brandenburg, George; Brandt, Andrew; Brandt, Gerhard; Brandt, Oleg; Bratzler, Uwe; Brau, Benjamin; Brau, James; Braun, Helmut; Brelier, Bertrand; Bremer, Johan; Brenner, Richard; Bressler, Shikma; Britton, Dave; Brochu, Frederic; Brock, Ian; Brock, Raymond; Brodet, Eyal; Bromberg, Carl; Brooijmans, Gustaaf; Brooks, William; Brown, Gareth; Bruckman de Renstrom, Pawel; Bruncko, Dusan; Bruneliere, Renaud; Brunet, Sylvie; Bruni, Alessia; Bruni, Graziano; Bruschi, Marco; Bucci, Francesca; Buchanan, James; Buchholz, Peter; Buckley, Andrew; Budagov, Ioulian; Budick, Burton; Büscher, Volker; Bugge, Lars; Bulekov, Oleg; Bunse, Moritz; Buran, Torleiv; Burckhart, Helfried; Burdin, Sergey; Burgess, Thomas; Burke, Stephen; Busato, Emmanuel; Bussey, Peter; Buszello, Claus-Peter; Butin, Françcois; Butler, Bart; Butler, John; Buttar, Craig; Butterworth, Jonathan; Byatt, Tom; Caballero, Jose; Cabrera Urbán, Susana; Caforio, Davide; Cakir, Orhan; Calafiura, Paolo; Calderini, Giovanni; Calfayan, Philippe; Calkins, Robert; Caloba, Luiz; Calvet, David; Camarri, Paolo; Cameron, David; Campana, Simone; Campanelli, Mario; Canale, Vincenzo; Canelli, Florencia; Canepa, Anadi; Cantero, Josu; Capasso, Luciano; Capeans Garrido, Maria Del Mar; Caprini, Irinel; Caprini, Mihai; Capua, Marcella; Caputo, Regina; Caramarcu, Costin; Cardarelli, Roberto; Carli, Tancredi; Carlino, Gianpaolo; Carminati, Leonardo; Caron, Bryan; Caron, Sascha; Carrillo Montoya, German D.; Carron Montero, Sebastian; Carter, Antony; Carter, Janet; Carvalho, João; Casadei, Diego; Casado, Maria Pilar; Cascella, Michele; Castaneda Hernandez, Alfredo Martin; Castaneda-Miranda, Elizabeth; Castillo Gimenez, Victoria; Castro, Nuno Filipe; Cataldi, Gabriella; Catinaccio, Andrea; Catmore, James; Cattai, Ariella; Cattani, Giordano; Caughron, Seth; Cauz, Diego; Cavalleri, Pietro; Cavalli, Donatella; Cavalli-Sforza, Matteo; Cavasinni, Vincenzo; Ceradini, Filippo; Cerqueira, Augusto Santiago; Cerri, Alessandro; Cerrito, Lucio; Cerutti, Fabio; Cetin, Serkant Ali; Chafaq, Aziz; Chakraborty, Dhiman; Chan, Kevin; Chapman, John Derek; Chapman, John Wehrley; Chareyre, Eve; Charlton, Dave; Chavda, Vikash; Cheatham, Susan; Chekanov, Sergei; Chekulaev, Sergey; Chelkov, Gueorgui; Chen, Hucheng; Chen, Shenjian; Chen, Xin; Cheplakov, Alexander; Chepurnov, Vladimir; Cherkaoui El Moursli, Rajaa; Tcherniatine, Valeri; Chesneanu, Daniela; Cheu, Elliott; Cheung, Sing-Leung; Chevalier, Laurent; Chevallier, Florent; Chiarella, Vitaliano; Chiefari, Giovanni; Chikovani, Leila; Childers, John Taylor; Chilingarov, Alexandre; Chiodini, Gabriele; Chizhov, Mihail; Choudalakis, Georgios; Chouridou, Sofia; Christidi, Illectra-Athanasia; Christov, Asen; Chromek-Burckhart, Doris; Chu, Ming-Lee; Chudoba, Jiri; Ciapetti, Guido; Ciftci, Abbas Kenan; Ciftci, Rena; Cinca, Diane; Cindro, Vladimir; Ciobotaru, Matei Dan; Ciocca, Claudia; Ciocio, Alessandra; Cirilli, Manuela; Citterio, Mauro; Clark, Allan G.; Clark, Philip James; Cleland, Bill; Clemens, Jean-Claude; Clement, Benoit; Clement, Christophe; Coadou, Yann; Cobal, Marina; Coccaro, Andrea; Cochran, James H.; Coggeshall, James; Cogneras, Eric; Colijn, Auke-Pieter; Collard, Caroline; Collins, Neil; Collins-Tooth, Christopher; Collot, Johann; Colon, German; Conde Muiño, Patricia; Coniavitis, Elias; Consonni, Michele; Constantinescu, Serban; Conta, Claudio; Conventi, Francesco; Cooke, Mark; Cooper, Ben; Cooper-Sarkar, Amanda; Cooper-Smith, Neil; Copic, Katherine; Cornelissen, Thijs; Corradi, Massimo; Corriveau, Francois; Corso-Radu, Alina; Cortes-Gonzalez, Arely; Cortiana, Giorgio; Costa, Giuseppe; Costa, María José; Costanzo, Davide; Costin, Tudor; Côté, David; Coura Torres, Rodrigo; Courneyea, Lorraine; Cowan, Glen; Cowden, Christopher; Cox, Brian; Cranmer, Kyle; Cranshaw, Jack; Cristinziani, Markus; Crosetti, Giovanni; Crupi, Roberto; Crépé-Renaudin, Sabine; Cuenca Almenar, Cristóbal; Cuhadar Donszelmann, Tulay; Curatolo, Maria; Curtis, Chris; Cwetanski, Peter; Czyczula, Zofia; D'Auria, Saverio; D'Onofrio, Monica; D'Orazio, Alessia; Da Via, Cinzia; Dabrowski, Wladyslaw; Dai, Tiesheng; Dallapiccola, Carlo; Dallison, Steve; Daly, Colin; Dam, Mogens; Danielsson, Hans Olof; Dannheim, Dominik; Dao, Valerio; Darbo, Giovanni; Darlea, Georgiana Lavinia; Davey, Will; Davidek, Tomas; Davidson, Nadia; Davidson, Ruth; Davies, Merlin; Davison, Adam; Dawson, Ian; Daya, Rozmin; De, Kaushik; de Asmundis, Riccardo; De Castro, Stefano; De Castro Faria Salgado, Pedro; De Cecco, Sandro; de Graat, Julien; De Groot, Nicolo; de Jong, Paul; De Mora, Lee; De Oliveira Branco, Miguel; De Pedis, Daniele; De Salvo, Alessandro; De Sanctis, Umberto; De Santo, Antonella; De Vivie De Regie, Jean-Baptiste; De Zorzi, Guido; Dean, Simon; Dedovich, Dmitri; Degenhardt, James; Dehchar, Mohamed; Del Papa, Carlo; Del Peso, Jose; Del Prete, Tarcisio; Dell'Acqua, Andrea; Dell'Asta, Lidia; Della Pietra, Massimo; della Volpe, Domenico; Delmastro, Marco; Delsart, Pierre-Antoine; Deluca, Carolina; Demers, Sarah; Demichev, Mikhail; Demirkoz, Bilge; Deng, Jianrong; Deng, Wensheng; Denisov, Sergey; Derkaoui, Jamal Eddine; Derue, Frederic; Dervan, Paul; Desch, Klaus Kurt; Deviveiros, Pier-Olivier; Dewhurst, Alastair; DeWilde, Burton; Dhaliwal, Saminder; Dhullipudi, Ramasudhakar; Di Ciaccio, Anna; Di Ciaccio, Lucia; Di Domenico, Antonio; Di Girolamo, Alessandro; Di Girolamo, Beniamino; Di Luise, Silvestro; Di Mattia, Alessandro; Di Nardo, Roberto; Di Simone, Andrea; Di Sipio, Riccardo; Diaz, Marco Aurelio; Diblen, Faruk; Diehl, Edward; Dietrich, Janet; Dietzsch, Thorsten; Diglio, Sara; Dindar Yagci, Kamile; Dingfelder, Jochen; Dionisi, Carlo; Dita, Petre; Dita, Sanda; Dittus, Fridolin; Djama, Fares; Djilkibaev, Rashid; Djobava, Tamar; do Vale, Maria Aline Barros; Do Valle Wemans, André; Doan, Thi Kieu Oanh; Dobos, Daniel; Dobson, Ellie; Dobson, Marc; Doglioni, Caterina; Doherty, Tom; Dolejsi, Jiri; Dolenc, Irena; Dolezal, Zdenek; Dolgoshein, Boris; Dohmae, Takeshi; Donega, Mauro; Donini, Julien; Dopke, Jens; Doria, Alessandra; Dos Anjos, Andre; Dotti, Andrea; Dova, Maria-Teresa; Doxiadis, Alexander; Doyle, Tony; Drasal, Zbynek; Dris, Manolis; Dubbert, Jörg; Duchovni, Ehud; Duckeck, Guenter; Dudarev, Alexey; Dudziak, Fanny; Dührssen , Michael; Duflot, Laurent; Dufour, Marc-Andre; Dunford, Monica; Duran Yildiz, Hatice; Dushkin, Andrei; Duxfield, Robert; Dwuznik, Michal; Düren, Michael; Ebenstein, William; Ebke, Johannes; Eckweiler, Sebastian; Edmonds, Keith; Edwards, Clive; Egorov, Kirill; Ehrenfeld, Wolfgang; Ehrich, Thies; Eifert, Till; Eigen, Gerald; Einsweiler, Kevin; Eisenhandler, Eric; Ekelof, Tord; El Kacimi, Mohamed; Ellert, Mattias; Elles, Sabine; Ellinghaus, Frank; Ellis, Katherine; Ellis, Nicolas; Elmsheuser, Johannes; Elsing, Markus; Emeliyanov, Dmitry; Engelmann, Roderich; Engl, Albert; Epp, Brigitte; Eppig, Andrew; Erdmann, Johannes; Ereditato, Antonio; Eriksson, Daniel; Ermoline, Iouri; Ernst, Jesse; Ernst, Michael; Ernwein, Jean; Errede, Deborah; Errede, Steven; Ertel, Eugen; Escalier, Marc; Escobar, Carlos; Espinal Curull, Xavier; Esposito, Bellisario; Etienvre, Anne-Isabelle; Etzion, Erez; Evans, Hal; Fabbri, Laura; Fabre, Caroline; Facius, Katrine; Fakhrutdinov, Rinat; Falciano, Speranza; Fang, Yaquan; Fanti, Marcello; Farbin, Amir; Farilla, Addolorata; Farley, Jason; Farooque, Trisha; Farrington, Sinead; Farthouat, Philippe; Fassnacht, Patrick; Fassouliotis, Dimitrios; Fatholahzadeh, Baharak; Fayard, Louis; Fayette, Florent; Febbraro, Renato; Federic, Pavol; Fedin, Oleg; Fedorko, Woiciech; Feligioni, Lorenzo; Felzmann, Ulrich; Feng, Cunfeng; Feng, Eric; Fenyuk, Alexander; Ferencei, Jozef; Ferland, Jonathan; Fernandes, Bruno; Fernando, Waruna; Ferrag, Samir; Ferrando, James; Ferrara, Valentina; Ferrari, Arnaud; Ferrari, Pamela; Ferrari, Roberto; Ferrer, Antonio; Ferrer, Maria Lorenza; Ferrere, Didier; Ferretti, Claudio; Fiascaris, Maria; Fiedler, Frank; Filipčič, Andrej; Filippas, Anastasios; Filthaut, Frank; Fincke-Keeler, Margret; Fiolhais, Miguel; Fiorini, Luca; Firan, Ana; Fischer, Gordon; Fisher, Matthew; Flechl, Martin; Fleck, Ivor; Fleckner, Johanna; Fleischmann, Philipp; Fleischmann, Sebastian; Flick, Tobias; Flores Castillo, Luis; Flowerdew, Michael; Fonseca Martin, Teresa; Formica, Andrea; Forti, Alessandra; Fortin, Dominique; Fournier, Daniel; Fowler, Andrew; Fowler, Ken; Fox, Harald; Francavilla, Paolo; Franchino, Silvia; Francis, David; Franklin, Melissa; Franz, Sebastien; Fraternali, Marco; Fratina, Sasa; Freestone, Julian; French, Sky; Froeschl, Robert; Froidevaux, Daniel; Frost, James; Fukunaga, Chikara; Fullana Torregrosa, Esteban; Fuster, Juan; Gabaldon, Carolina; Gabizon, Ofir; Gadfort, Thomas; Gadomski, Szymon; Gagliardi, Guido; Gagnon, Pauline; Galea, Cristina; Gallas, Elizabeth; Gallas, Manuel; Gallo, Valentina Santina; Gallop, Bruce; Gallus, Petr; Galyaev, Eugene; Gan, K K; Gao, Yongsheng; Gaponenko, Andrei; Garcia-Sciveres, Maurice; García, Carmen; García Navarro, José Enrique; Gardner, Robert; Garelli, Nicoletta; Garitaonandia, Hegoi; Garonne, Vincent; Gatti, Claudio; Gaudio, Gabriella; Gautard, Valerie; Gauzzi, Paolo; Gavrilenko, Igor; Gay, Colin; Gaycken, Goetz; Gazis, Evangelos; Ge, Peng; Gee, Norman; Geich-Gimbel, Christoph; Gellerstedt, Karl; Gemme, Claudia; Genest, Marie-Hélène; Gentile, Simonetta; Georgatos, Fotios; George, Simon; Gershon, Avi; Ghazlane, Hamid; Ghodbane, Nabil; Giacobbe, Benedetto; Giagu, Stefano; Giakoumopoulou, Victoria; Giangiobbe, Vincent; Gianotti, Fabiola; Gibbard, Bruce; Gibson, Adam; Gibson, Stephen; Gilbert, Laura; Gilchriese, Murdock; Gilewsky, Valentin; Gingrich, Douglas; Ginzburg, Jonatan; Giokaris, Nikos; Giordani, MarioPaolo; Giordano, Raffaele; Giorgi, Francesco Michelangelo; Giovannini, Paola; Giraud, Pierre-Francois; Girtler, Peter; Giugni, Danilo; Giusti, Paolo; Gjelsten, Børge Kile; Gladilin, Leonid; Glasman, Claudia; Glazov, Alexandre; Glitza, Karl-Walter; Glonti, George; Godfrey, Jennifer; Godlewski, Jan; Goebel, Martin; Göpfert, Thomas; Goeringer, Christian; Gössling, Claus; Göttfert, Tobias; Goggi, Virginio; Goldfarb, Steven; Goldin, Daniel; Golling, Tobias; Gomes, Agostinho; Gomez Fajardo, Luz Stella; Gonçcalo, Ricardo; Gonella, Laura; Gong, Chenwei; González de la Hoz, Santiago; Gonzalez Silva, Laura; Gonzalez-Sevilla, Sergio; Goodson, Jeremiah Jet; Goossens, Luc; Gordon, Howard; Gorelov, Igor; Gorfine, Grant; Gorini, Benedetto; Gorini, Edoardo; Gorišek, Andrej; Gornicki, Edward; Gosdzik, Bjoern; Gosselink, Martijn; Gostkin, Mikhail Ivanovitch; Gough Eschrich, Ivo; Gouighri, Mohamed; Goujdami, Driss; Goulette, Marc Phillippe; Goussiou, Anna; Goy, Corinne; Grabowska-Bold, Iwona; Grafström, Per; Grahn, Karl-Johan; Grancagnolo, Sergio; Grassi, Valerio; Gratchev, Vadim; Grau, Nathan; Gray, Heather; Gray, Julia Ann; Graziani, Enrico; Green, Barry; Greenshaw, Timothy; Greenwood, Zeno Dixon; Gregor, Ingrid-Maria; Grenier, Philippe; Griesmayer, Erich; Griffiths, Justin; Grigalashvili, Nugzar; Grillo, Alexander; Grimm, Kathryn; Grinstein, Sebastian; Grishkevich, Yaroslav; Groh, Manfred; Groll, Marius; Gross, Eilam; Grosse-Knetter, Joern; Groth-Jensen, Jacob; Grybel, Kai; Guicheney, Christophe; Guida, Angelo; Guillemin, Thibault; Guler, Hulya; Gunther, Jaroslav; Guo, Bin; Gupta, Ambreesh; Gusakov, Yury; Gutierrez, Andrea; Gutierrez, Phillip; Guttman, Nir; Gutzwiller, Olivier; Guyot, Claude; Gwenlan, Claire; Gwilliam, Carl; Haas, Andy; Haas, Stefan; Haber, Carl; Hadavand, Haleh Khani; Hadley, David; Haefner, Petra; Härtel, Roland; Hajduk, Zbigniew; Hakobyan, Hrachya; Haller, Johannes; Hamacher, Klaus; Hamilton, Andrew; Hamilton, Samuel; Han, Liang; Hanagaki, Kazunori; Hance, Michael; Handel, Carsten; Hanke, Paul; Hansen, Jørgen Beck; Hansen, Jorn Dines; Hansen, John Renner; Hansen, Peter Henrik; Hansl-Kozanecka, Traudl; Hansson, Per; Hara, Kazuhiko; Hare, Gabriel; Harenberg, Torsten; Harrington, Robert; Harris, Orin; Harrison, Karl; Hartert, Jochen; Hartjes, Fred; Harvey, Alex; Hasegawa, Satoshi; Hasegawa, Yoji; Hashemi, Kevan; Hassani, Samira; Haug, Sigve; Hauschild, Michael; Hauser, Reiner; Havranek, Miroslav; Hawkes, Christopher; Hawkings, Richard John; Hayakawa, Takashi; Hayward, Helen; Haywood, Stephen; Head, Simon; Hedberg, Vincent; Heelan, Louise; Heim, Sarah; Heinemann, Beate; Heisterkamp, Simon; Helary, Louis; Heller, Mathieu; Hellman, Sten; Helsens, Clement; Hemperek, Tomasz; Henderson, Robert; Henke, Michael; Henrichs, Anna; Henriques Correia, Ana Maria; Henrot-Versille, Sophie; Hensel, Carsten; Henß, Tobias; Hernández Jiménez, Yesenia; Hershenhorn, Alon David; Herten, Gregor; Hertenberger, Ralf; Hervas, Luis; Hessey, Nigel; Higón-Rodriguez, Emilio; Hill, John; Hiller, Karl Heinz; Hillert, Sonja; Hillier, Stephen; Hinchliffe, Ian; Hines, Elizabeth; Hirose, Minoru; Hirsch, Florian; Hirschbuehl, Dominic; Hobbs, John; Hod, Noam; Hodgkinson, Mark; Hodgson, Paul; Hoecker, Andreas; Hoeferkamp, Martin; Hoffman, Julia; Hoffmann, Dirk; Hohlfeld, Marc; Holy, Tomas; Holzbauer, Jenny; Homma, Yasuhiro; Horazdovsky, Tomas; Hori, Takuya; Horn, Claus; Horner, Stephan; Hostachy, Jean-Yves; Hou, Suen; Hoummada, Abdeslam; Howe, Travis; Hrivnac, Julius; Hryn'ova, Tetiana; Hsu, Pai-hsien Jennifer; Hsu, Shih-Chieh; Huang, Guang Shun; Hubacek, Zdenek; Hubaut, Fabrice; Huegging, Fabian; Hughes, Emlyn; Hughes, Gareth; Hurwitz, Martina; Husemann, Ulrich; Huseynov, Nazim; Huston, Joey; Huth, John; Iacobucci, Giuseppe; Iakovidis, Georgios; Ibragimov, Iskander; Iconomidou-Fayard, Lydia; Idarraga, John; Iengo, Paolo; Igonkina, Olga; Ikegami, Yoichi; Ikeno, Masahiro; Ilchenko, Yuri; Iliadis, Dimitrios; Ince, Tayfun; Ioannou, Pavlos; Iodice, Mauro; Irles Quiles, Adrian; Ishikawa, Akimasa; Ishino, Masaya; Ishmukhametov, Renat; Isobe, Tadaaki; Issakov, Vladimir; Issever, Cigdem; Istin, Serhat; Itoh, Yuki; Ivashin, Anton; Iwanski, Wieslaw; Iwasaki, Hiroyuki; Izen, Joseph; Izzo, Vincenzo; Jackson, Brett; Jackson, John; Jackson, Paul; Jaekel, Martin; Jain, Vivek; Jakobs, Karl; Jakobsen, Sune; Jakubek, Jan; Jana, Dilip; Jansen, Eric; Jantsch, Andreas; Janus, Michel; Jared, Richard; Jarlskog, Göran; Jeanty, Laura; Jen-La Plante, Imai; Jenni, Peter; Jež, Pavel; Jézéquel, Stéphane; Ji, Weina; Jia, Jiangyong; Jiang, Yi; Jimenez Belenguer, Marcos; Jin, Shan; Jinnouchi, Osamu; Joffe, David; Johansen, Marianne; Johansson, Erik; Johansson, Per; Johnert, Sebastian; Johns, Kenneth; Jon-And, Kerstin; Jones, Graham; Jones, Roger; Jones, Tim; Jorge, Pedro; Joseph, John; Juranek, Vojtech; Jussel, Patrick; Kabachenko, Vasily; Kaci, Mohammed; Kaczmarska, Anna; Kado, Marumi; Kagan, Harris; Kagan, Michael; Kaiser, Steffen; Kajomovitz, Enrique; Kalinin, Sergey; Kalinovskaya, Lidia; Kalinowski, Artur; Kama, Sami; Kanaya, Naoko; Kaneda, Michiru; Kantserov, Vadim; Kanzaki, Junichi; Kaplan, Benjamin; Kapliy, Anton; Kaplon, Jan; Kar, Deepak; Karagounis, Michael; Karagoz, Muge; Kartvelishvili, Vakhtang; Karyukhin, Andrey; Kashif, Lashkar; Kasmi, Azzedine; Kass, Richard; Kastanas, Alex; Kastoryano, Michael; Kataoka, Mayuko; Kataoka, Yousuke; Katsoufis, Elias; Katzy, Judith; Kaushik, Venkatesh; Kawagoe, Kiyotomo; Kawamoto, Tatsuo; Kawamura, Gen; Kayl, Manuel; Kayumov, Fred; Kazanin, Vassili; Kazarinov, Makhail; Keates, James Robert; Keeler, Richard; Keener, Paul; Kehoe, Robert; Keil, Markus; Kekelidze, George; Kelly, Marc; Kenyon, Mike; Kepka, Oldrich; Kerschen, Nicolas; Kerševan, Borut Paul; Kersten, Susanne; Kessoku, Kohei; Khakzad, Mohsen; Khalil-zada, Farkhad; Khandanyan, Hovhannes; Khanov, Alexander; Kharchenko, Dmitri; Khodinov, Alexander; Khomich, Andrei; Khoriauli, Gia; Khovanskiy, Nikolai; Khovanskiy, Valery; Khramov, Evgeniy; Khubua, Jemal; Kim, Hyeon Jin; Kim, Min Suk; Kim, Peter; Kim, Shinhong; Kind, Oliver; Kind, Peter; King, Barry; Kirk, Julie; Kirsch, Guillaume; Kirsch, Lawrence; Kiryunin, Andrey; Kisielewska, Danuta; Kittelmann, Thomas; Kiyamura, Hironori; Kladiva, Eduard; Klein, Max; Klein, Uta; Kleinknecht, Konrad; Klemetti, Miika; Klier, Amit; Klimentov, Alexei; Klingenberg, Reiner; Klinkby, Esben; Klioutchnikova, Tatiana; Klok, Peter; Klous, Sander; Kluge, Eike-Erik; Kluge, Thomas; Kluit, Peter; Klute, Markus; Kluth, Stefan; Knecht, Neil; Kneringer, Emmerich; Ko, Byeong Rok; Kobayashi, Tomio; Kobel, Michael; Koblitz, Birger; Kocian, Martin; Kocnar, Antonin; Kodys, Peter; Köneke, Karsten; König, Adriaan; Koenig, Sebastian; Köpke, Lutz; Koetsveld, Folkert; Koevesarki, Peter; Koffas, Thomas; Koffeman, Els; Kohn, Fabian; Kohout, Zdenek; Kohriki, Takashi; Kolanoski, Hermann; Kolesnikov, Vladimir; Koletsou, Iro; Koll, James; Kollar, Daniel; Kolos, Serguei; Kolya, Scott; Komar, Aston; Komaragiri, Jyothsna Rani; Kondo, Takahiko; Kono, Takanori; Konoplich, Rostislav; Konovalov, Serguei; Konstantinidis, Nikolaos; Koperny, Stefan; Korcyl, Krzysztof; Kordas, Kostantinos; Korn, Andreas; Korolkov, Ilya; Korolkova, Elena; Korotkov, Vladislav; Kortner, Oliver; Kortner, Sandra; Kostka, Peter; Kostyukhin, Vadim; Kotov, Serguei; Kotov, Vladislav; Kotov, Konstantin; Kourkoumelis, Christine; Koutsman, Alex; Kowalewski, Robert Victor; Kowalski, Henri; Kowalski, Tadeusz; Kozanecki, Witold; Kozhin, Anatoly; Kral, Vlastimil; Kramarenko, Viktor; Kramberger, Gregor; Krasny, Mieczyslaw Witold; Krasznahorkay, Attila; Kreisel, Arik; Krejci, Frantisek; Kretzschmar, Jan; Krieger, Nina; Krieger, Peter; Kroeninger, Kevin; Kroha, Hubert; Kroll, Joe; Kroseberg, Juergen; Krstic, Jelena; Kruchonak, Uladzimir; Krüger, Hans; Krumshteyn, Zinovii; Kubota, Takashi; Kuehn, Susanne; Kugel, Andreas; Kuhl, Thorsten; Kuhn, Dietmar; Kukhtin, Victor; Kulchitsky, Yuri; Kuleshov, Sergey; Kummer, Christian; Kuna, Marine; Kunkle, Joshua; Kupco, Alexander; Kurashige, Hisaya; Kurata, Masakazu; Kurchaninov, Leonid; Kurochkin, Yurii; Kus, Vlastimil; Kwee, Regina; La Rotonda, Laura; Labbe, Julien; Lacasta, Carlos; Lacava, Francesco; Lacker, Heiko; Lacour, Didier; Lacuesta, Vicente Ramón; Ladygin, Evgueni; Lafaye, Rémi; Laforge, Bertrand; Lagouri, Theodota; Lai, Stanley; Lamanna, Massimo; Lampen, Caleb; Lampl, Walter; Lancon, Eric; Landgraf, Ulrich; Landon, Murrough; Lane, Jenna; Lankford, Andrew; Lanni, Francesco; Lantzsch, Kerstin; Lanza, Agostino; Laplace, Sandrine; Lapoire, Cecile; Laporte, Jean-Francois; Lari, Tommaso; Larner, Aimee; Lassnig, Mario; Laurelli, Paolo; Lavrijsen, Wim; Laycock, Paul; Lazarev, Alexandre; Lazzaro, Alfio; Le Dortz, Olivier; Le Guirriec, Emmanuel; Le Menedeu, Eve; Le Vine, Micheal; Lebedev, Alexander; Lebel, Céline; LeCompte, Thomas; Ledroit-Guillon, Fabienne Agnes Marie; Lee, Hurng-Chun; Lee, Jason; Lee, Shih-Chang; Lefebvre, Michel; Legendre, Marie; LeGeyt, Benjamin; Legger, Federica; Leggett, Charles; Lehmacher, Marc; Lehmann Miotto, Giovanna; Lei, Xiaowen; Leitner, Rupert; Lellouch, Daniel; Lellouch, Jeremie; Lendermann, Victor; Leney, Katharine; Lenz, Tatiana; Lenzen, Georg; Lenzi, Bruno; Leonhardt, Kathrin; Leroy, Claude; Lessard, Jean-Raphael; Lester, Christopher; Leung Fook Cheong, Annabelle; Levêque, Jessica; Levin, Daniel; Levinson, Lorne; Leyton, Michael; Li, Haifeng; Li, Shumin; Li, Xuefei; Liang, Zhihua; Liang, Zhijun; Liberti, Barbara; Lichard, Peter; Lichtnecker, Markus; Lie, Ki; Liebig, Wolfgang; Lilley, Joseph; Lim, Heuijin; Limosani, Antonio; Limper, Maaike; Lin, Simon; Linnemann, James; Lipeles, Elliot; Lipinsky, Lukas; Lipniacka, Anna; Liss, Tony; Lissauer, David; Lister, Alison; Litke, Alan; Liu, Chuanlei; Liu, Dong; Liu, Hao; Liu, Jianbei; Liu, Minghui; Liu, Tiankuan; Liu, Yanwen; Livan, Michele; Lleres, Annick; Lloyd, Stephen; Lobodzinska, Ewelina; Loch, Peter; Lockman, William; Lockwitz, Sarah; Loddenkoetter, Thomas; Loebinger, Fred; Loginov, Andrey; Loh, Chang Wei; Lohse, Thomas; Lohwasser, Kristin; Lokajicek, Milos; Long, Robin Eamonn; Lopes, Lourenco; Lopez Mateos, David; Losada, Marta; Loscutoff, Peter; Lou, Xinchou; Lounis, Abdenour; Loureiro, Karina; Lovas, Lubomir; Love, Jeremy; Love, Peter; Lowe, Andrew; Lu, Feng; Lubatti, Henry; Luci, Claudio; Lucotte, Arnaud; Ludwig, Andreas; Ludwig, Dörthe; Ludwig, Inga; Luehring, Frederick; Luisa, Luca; Lumb, Debra; Luminari, Lamberto; Lund, Esben; Lund-Jensen, Bengt; Lundberg, Björn; Lundberg, Johan; Lundquist, Johan; Lynn, David; Lys, Jeremy; Lytken, Else; Ma, Hong; Ma, Lian Liang; Macana Goia, Jorge Andres; Maccarrone, Giovanni; Macchiolo, Anna; Maček, Boštjan; Machado Miguens, Joana; Mackeprang, Rasmus; Madaras, Ronald; Mader, Wolfgang; Maenner, Reinhard; Maeno, Tadashi; Mättig, Peter; Mättig, Stefan; Magalhaes Martins, Paulo Jorge; Magradze, Erekle; Mahalalel, Yair; Mahboubi, Kambiz; Mahmood, A.; Maiani, Camilla; Maidantchik, Carmen; Maio, Amélia; Majewski, Stephanie; Makida, Yasuhiro; Makouski, Mikhail; Makovec, Nikola; Malecki, Piotr; Malecki, Pawel; Maleev, Victor; Malek, Fairouz; Mallik, Usha; Malon, David; Maltezos, Stavros; Malyshev, Vladimir; Malyukov, Sergei; Mambelli, Marco; Mameghani, Raphael; Mamuzic, Judita; Mandelli, Luciano; Mandić, Igor; Mandrysch, Rocco; Maneira, José; Mangeard, Pierre-Simon; Manjavidze, Ioseb; Manning, Peter; Manousakis-Katsikakis, Arkadios; Mansoulie, Bruno; Mapelli, Alessandro; Mapelli, Livio; March , Luis; Marchand, Jean-Francois; Marchese, Fabrizio; Marchiori, Giovanni; Marcisovsky, Michal; Marino, Christopher; Marroquim, Fernando; Marshall, Zach; Marti-Garcia, Salvador; Martin, Alex; Martin, Andrew; Martin, Brian; Martin, Brian; Martin, Franck Francois; Martin, Jean-Pierre; Martin, Tim; Martin dit Latour, Bertrand; Martinez, Mario; Martinez Outschoorn, Verena; Martini, Agnese; Martyniuk, Alex; Marzano, Francesco; Marzin, Antoine; Masetti, Lucia; Mashimo, Tetsuro; Mashinistov, Ruslan; Masik, Jiri; Maslennikov, Alexey; Massa, Ignazio; Massol, Nicolas; Mastroberardino, Anna; Masubuchi, Tatsuya; Matricon, Pierre; Matsunaga, Hiroyuki; Matsushita, Takashi; Mattravers, Carly; Maxfield, Stephen; Mayne, Anna; Mazini, Rachid; Mazur, Michael; Mazzanti, Marcello; Mc Donald, Jeffrey; Mc Kee, Shawn Patrick; McCarn, Allison; McCarthy, Robert; McCubbin, Norman; McFarlane, Kenneth; McGlone, Helen; Mchedlidze, Gvantsa; McMahon, Steve; McPherson, Robert; Meade, Andrew; Mechnich, Joerg; Mechtel, Markus; Medinnis, Mike; Meera-Lebbai, Razzak; Meguro, Tatsuma; Mehlhase, Sascha; Mehta, Andrew; Meier, Karlheinz; Meirose, Bernhard; Melachrinos, Constantinos; Mellado Garcia, Bruce Rafael; Mendoza Navas, Luis; Meng, Zhaoxia; Menke, Sven; Meoni, Evelin; Mermod, Philippe; Merola, Leonardo; Meroni, Chiara; Merritt, Frank; Messina, Andrea; Metcalfe, Jessica; Mete, Alaettin Serhan; Meyer, Jean-Pierre; Meyer, Jochen; Meyer, Joerg; Meyer, Thomas Christian; Meyer, W. Thomas; Miao, Jiayuan; Michal, Sebastien; Micu, Liliana; Middleton, Robin; Migas, Sylwia; Mijović, Liza; Mikenberg, Giora; Mikestikova, Marcela; Mikuž, Marko; Miller, David; Mills, Corrinne; Mills, Bill; Milov, Alexander; Milstead, David; Milstein, Dmitry; Minaenko, Andrey; Miñano, Mercedes; Minashvili, Irakli; Mincer, Allen; Mindur, Bartosz; Mineev, Mikhail; Ming, Yao; Mir, Lluisa-Maria; Mirabelli, Giovanni; Misawa, Shigeki; Miscetti, Stefano; Misiejuk, Andrzej; Mitrevski, Jovan; Mitsou, Vasiliki A.; Miyagawa, Paul; Mjörnmark, Jan-Ulf; Mladenov, Dimitar; Moa, Torbjoern; Moed, Shulamit; Moeller, Victoria; Mönig, Klaus; Möser, Nicolas; Mohr, Wolfgang; Mohrdieck-Möck, Susanne; Moles-Valls, Regina; Molina-Perez, Jorge; Monk, James; Monnier, Emmanuel; Montesano, Simone; Monticelli, Fernando; Moore, Roger; Mora Herrera, Clemencia; Moraes, Arthur; Morais, Antonio; Morel, Julien; Morello, Gianfranco; Moreno, Deywis; Moreno Llácer, María; Morettini, Paolo; Morii, Masahiro; Morley, Anthony Keith; Mornacchi, Giuseppe; Morozov, Sergey; Morris, John; Moser, Hans-Guenther; Mosidze, Maia; Moss, Josh; Mount, Richard; Mountricha, Eleni; Mouraviev, Sergei; Moyse, Edward; Mudrinic, Mihajlo; Mueller, Felix; Mueller, James; Mueller, Klemens; Müller, Thomas; Muenstermann, Daniel; Muir, Alex; Munwes, Yonathan; Murillo Garcia, Raul; Murray, Bill; Mussche, Ido; Musto, Elisa; Myagkov, Alexey; Myska, Miroslav; Nadal, Jordi; Nagai, Koichi; Nagano, Kunihiro; Nagasaka, Yasushi; Nairz, Armin Michael; Nakamura, Koji; Nakano, Itsuo; Nakatsuka, Hiroki; Nanava, Gizo; Napier, Austin; Nash, Michael; Nation, Nigel; Nattermann, Till; Naumann, Thomas; Navarro, Gabriela; Nderitu, Simon Kirichu; Neal, Homer; Nebot, Eduardo; Nechaeva, Polina; Negri, Andrea; Negri, Guido; Nelson, Andrew; Nelson, Timothy Knight; Nemecek, Stanislav; Nemethy, Peter; Nepomuceno, Andre Asevedo; Nessi, Marzio; Neubauer, Mark; Neusiedl, Andrea; Neves, Ricardo; Nevski, Pavel; Newcomer, Mitchel; Nickerson, Richard; Nicolaidou, Rosy; Nicolas, Ludovic; Nicoletti, Giovanni; Nicquevert, Bertrand; Niedercorn, Francois; Nielsen, Jason; Nikiforov, Andriy; Nikolaev, Kirill; Nikolic-Audit, Irena; Nikolopoulos, Konstantinos; Nilsen, Henrik; Nilsson, Paul; Nisati, Aleandro; Nishiyama, Tomonori; Nisius, Richard; Nodulman, Lawrence; Nomachi, Masaharu; Nomidis, Ioannis; Nordberg, Markus; Nordkvist, Bjoern; Notz, Dieter; Novakova, Jana; Nozaki, Mitsuaki; Nožička, Miroslav; Nugent, Ian Michael; Nuncio-Quiroz, Adriana-Elizabeth; Nunes Hanninger, Guilherme; Nunnemann, Thomas; Nurse, Emily; O'Neil, Dugan; O'Shea, Val; Oakham, Gerald; Oberlack, Horst; Ochi, Atsuhiko; Oda, Susumu; Odaka, Shigeru; Odier, Jerome; Ogren, Harold; Oh, Alexander; Oh, Seog; Ohm, Christian; Ohshima, Takayoshi; Ohshita, Hidetoshi; Ohsugi, Takashi; Okada, Shogo; Okawa, Hideki; Okumura, Yasuyuki; Okuyama, Toyonobu; Olchevski, Alexander; Oliveira, Miguel Alfonso; Oliveira Damazio, Denis; Oliver, John; Oliver Garcia, Elena; Olivito, Dominick; Olszewski, Andrzej; Olszowska, Jolanta; Omachi, Chihiro; Onofre, António; Onyisi, Peter; Oram, Christopher; Oreglia, Mark; Oren, Yona; Orestano, Domizia; Orlov, Iliya; Oropeza Barrera, Cristina; Orr, Robert; Ortega, Eduardo; Osculati, Bianca; Ospanov, Rustem; Osuna, Carlos; Ottersbach, John; Ould-Saada, Farid; Ouraou, Ahmimed; Ouyang, Qun; Owen, Mark; Owen, Simon; Oyarzun, Alejandro; Ozcan, Veysi Erkcan; Ozone, Kenji; Ozturk, Nurcan; Pacheco Pages, Andres; Padilla Aranda, Cristobal; Paganis, Efstathios; Pahl, Christoph; Paige, Frank; Pajchel, Katarina; Palestini, Sandro; Pallin, Dominique; Palma, Alberto; Palmer, Jody; Pan, Yibin; Panagiotopoulou, Evgenia; Panes, Boris; Panikashvili, Natalia; Panitkin, Sergey; Pantea, Dan; Panuskova, Monika; Paolone, Vittorio; Papadopoulou, Theodora; Park, Su-Jung; Park, Woochun; Parker, Andy; Parker, Sherwood; Parodi, Fabrizio; Parsons, John; Parzefall, Ulrich; Pasqualucci, Enrico; Passeri, Antonio; Pastore, Fernanda; Pastore, Francesca; Pásztor , Gabriella; Pataraia, Sophio; Pater, Joleen; Patricelli, Sergio; Patwa, Abid; Pauly, Thilo; Peak, Lawrence; Pecsy, Martin; Pedraza Morales, Maria Isabel; Peleganchuk, Sergey; Peng, Haiping; Penson, Alexander; Penwell, John; Perantoni, Marcelo; Perez, Kerstin; Perez Codina, Estel; Pérez García-Estañ, María Teresa; Perez Reale, Valeria; Perini, Laura; Pernegger, Heinz; Perrino, Roberto; Persembe, Seda; Perus, Antoine; Peshekhonov, Vladimir; Petersen, Brian; Petersen, Troels; Petit, Elisabeth; Petridou, Chariclia; Petrolo, Emilio; Petrucci, Fabrizio; Petschull, Dennis; Petteni, Michele; Pezoa, Raquel; Phan, Anna; Phillips, Alan; Piacquadio, Giacinto; Piccinini, Maurizio; Piegaia, Ricardo; Pilcher, James; Pilkington, Andrew; Pina, João Antonio; Pinamonti, Michele; Pinfold, James; Pinto, Belmiro; Pizio, Caterina; Placakyte, Ringaile; Plamondon, Mathieu; Pleier, Marc-Andre; Poblaguev, Andrei; Poddar, Sahill; Podlyski, Fabrice; Poffenberger, Paul; Poggioli, Luc; Pohl, Martin; Polci, Francesco; Polesello, Giacomo; Policicchio, Antonio; Polini, Alessandro; Poll, James; Polychronakos, Venetios; Pomeroy, Daniel; Pommès, Kathy; Ponsot, Patrick; Pontecorvo, Ludovico; Pope, Bernard; Popeneciu, Gabriel Alexandru; Popovic, Dragan; Poppleton, Alan; Popule, Jiri; Portell Bueso, Xavier; Porter, Robert; Pospelov, Guennady; Pospisil, Stanislav; Potekhin, Maxim; Potrap, Igor; Potter, Christina; Potter, Christopher; Potter, Keith; Poulard, Gilbert; Poveda, Joaquin; Prabhu, Robindra; Pralavorio, Pascal; Prasad, Srivas; Pravahan, Rishiraj; Pribyl, Lukas; Price, Darren; Price, Lawrence; Prichard, Paul; Prieur, Damien; Primavera, Margherita; Prokofiev, Kirill; Prokoshin, Fedor; Protopopescu, Serban; Proudfoot, James; Prudent, Xavier; Przysiezniak, Helenka; Psoroulas, Serena; Ptacek, Elizabeth; Puigdengoles, Carles; Purdham, John; Purohit, Milind; Puzo, Patrick; Pylypchenko, Yuriy; Qi, Ming; Qian, Jianming; Qian, Weiming; Qin, Zhonghua; Quadt, Arnulf; Quarrie, David; Quayle, William; Quinonez, Fernando; Raas, Marcel; Radeka, Veljko; Radescu, Voica; Radics, Balint; Rador, Tonguc; Ragusa, Francesco; Rahal, Ghita; Rahimi, Amir; Rajagopalan, Srinivasan; Rammensee, Michael; Rammes, Marcus; Rauscher, Felix; Rauter, Emanuel; Raymond, Michel; Read, Alexander Lincoln; Rebuzzi, Daniela; Redelbach, Andreas; Redlinger, George; Reece, Ryan; Reeves, Kendall; Reinherz-Aronis, Erez; Reinsch, Andreas; Reisinger, Ingo; Reljic, Dusan; Rembser, Christoph; Ren, Zhongliang; Renkel, Peter; Rescia, Sergio; Rescigno, Marco; Resconi, Silvia; Resende, Bernardo; Reznicek, Pavel; Rezvani, Reyhaneh; Richards, Alexander; Richards, Ronald; Richter, Robert; Richter-Was, Elzbieta; Ridel, Melissa; Rijpstra, Manouk; Rijssenbeek, Michael; Rimoldi, Adele; Rinaldi, Lorenzo; Rios, Ryan Randy; Riu, Imma; Rizatdinova, Flera; Rizvi, Eram; Roa Romero, Diego Alejandro; Robertson, Steven; Robichaud-Veronneau, Andree; Robinson, Dave; Robinson, James; Robinson, Mary; Robson, Aidan; Rocha de Lima, Jose Guilherme; Roda, Chiara; Roda Dos Santos, Denis; Rodriguez, Diego; Rodriguez Garcia, Yohany; Roe, Shaun; Røhne, Ole; Rojo, Victoria; Rolli, Simona; Romaniouk, Anatoli; Romanov, Victor; Romeo, Gaston; Romero Maltrana, Diego; Roos, Lydia; Ros, Eduardo; Rosati, Stefano; Rosenbaum, Gabriel; Rosselet, Laurent; Rossetti, Valerio; Rossi, Leonardo Paolo; Rotaru, Marina; Rothberg, Joseph; Rousseau, David; Royon, Christophe; Rozanov, Alexander; Rozen, Yoram; Ruan, Xifeng; Ruckert, Benjamin; Ruckstuhl, Nicole; Rud, Viacheslav; Rudolph, Gerald; Rühr, Frederik; Ruggieri, Federico; Ruiz-Martinez, Aranzazu; Rumyantsev, Leonid; Rurikova, Zuzana; Rusakovich, Nikolai; Rutherfoord, John; Ruwiedel, Christoph; Ruzicka, Pavel; Ryabov, Yury; Ryan, Patrick; Rybkin, Grigori; Rzaeva, Sevda; Saavedra, Aldo; Sadrozinski, Hartmut; Sadykov, Renat; Sakamoto, Hiroshi; Salamanna, Giuseppe; Salamon, Andrea; Saleem, Muhammad; Salihagic, Denis; Salnikov, Andrei; Salt, José; Salvachua Ferrando, Belén; Salvatore, Daniela; Salvatore, Pasquale Fabrizio; Salvucci, Antonio; Salzburger, Andreas; Sampsonidis, Dimitrios; Samset, Björn Hallvard; Sandaker, Heidi; Sander, Heinz Georg; Sanders, Michiel; Sandhoff, Marisa; Sandhu, Pawan; Sandstroem, Rikard; Sandvoss, Stephan; Sankey, Dave; Sanny, Bernd; Sansoni, Andrea; Santamarina Rios, Cibran; Santoni, Claudio; Santonico, Rinaldo; Saraiva, João; Sarangi, Tapas; Sarkisyan-Grinbaum, Edward; Sarri, Francesca; Sasaki, Osamu; Sasao, Noboru; Satsounkevitch, Igor; Sauvage, Gilles; Savard, Pierre; Savine, Alexandre; Savinov, Vladimir; Sawyer, Lee; Saxon, David; Says, Louis-Pierre; Sbarra, Carla; Sbrizzi, Antonio; Scannicchio, Diana; Schaarschmidt, Jana; Schacht, Peter; Schäfer, Uli; Schaetzel, Sebastian; Schaffer, Arthur; Schaile, Dorothee; Schamberger, R.~Dean; Schamov, Andrey; Schegelsky, Valery; Scheirich, Daniel; Schernau, Michael; Scherzer, Max; Schiavi, Carlo; Schieck, Jochen; Schioppa, Marco; Schlenker, Stefan; Schmidt, Evelyn; Schmieden, Kristof; Schmitt, Christian; Schmitz, Martin; Schott, Matthias; Schouten, Doug; Schovancova, Jaroslava; Schram, Malachi; Schreiner, Alexander; Schroeder, Christian; Schroer, Nicolai; Schroers, Marcel; Schultes, Joachim; Schultz-Coulon, Hans-Christian; Schumacher, Jan; Schumacher, Markus; Schumm, Bruce; Schune, Philippe; Schwanenberger, Christian; Schwartzman, Ariel; Schwemling, Philippe; Schwienhorst, Reinhard; Schwierz, Rainer; Schwindling, Jerome; Scott, Bill; Searcy, Jacob; Sedykh, Evgeny; Segura, Ester; Seidel, Sally; Seiden, Abraham; Seifert, Frank; Seixas, José; Sekhniaidze, Givi; Seliverstov, Dmitry; Sellden, Bjoern; Semprini-Cesari, Nicola; Serfon, Cedric; Serin, Laurent; Seuster, Rolf; Severini, Horst; Sevior, Martin; Sfyrla, Anna; Shabalina, Elizaveta; Shamim, Mansoora; Shan, Lianyou; Shank, James; Shao, Qi Tao; Shapiro, Marjorie; Shatalov, Pavel; Shaw, Kate; Sherman, Daniel; Sherwood, Peter; Shibata, Akira; Shimojima, Makoto; Shin, Taeksu; Shmeleva, Alevtina; Shochet, Mel; Shupe, Michael; Sicho, Petr; Sidoti, Antonio; Siegert, Frank; Siegrist, James; Sijacki, Djordje; Silbert, Ohad; Silver, Yiftah; Silverstein, Daniel; Silverstein, Samuel; Simak, Vladislav; Simic, Ljiljana; Simion, Stefan; Simmons, Brinick; Simonyan, Margar; Sinervo, Pekka; Sinev, Nikolai; Sipica, Valentin; Siragusa, Giovanni; Sisakyan, Alexei; Sivoklokov, Serguei; Sjölin, Jörgen; Sjursen, Therese; Skovpen, Kirill; Skubic, Patrick; Slater, Mark; Slavicek, Tomas; Sliwa, Krzysztof; Sloper, John erik; Sluka, Tomas; Smakhtin, Vladimir; Smirnov, Sergei; Smirnov, Yuri; Smirnova, Lidia; Smirnova, Oxana; Smith, Ben Campbell; Smith, Douglas; Smith, Kenway; Smizanska, Maria; Smolek, Karel; Snesarev, Andrei; Snow, Steve; Snow, Joel; Snuverink, Jochem; Snyder, Scott; Soares, Mara; Sobie, Randall; Sodomka, Jaromir; Soffer, Abner; Solans, Carlos; Solar, Michael; Solc, Jaroslav; Solfaroli Camillocci, Elena; Solodkov, Alexander; Solovyanov, Oleg; Soluk, Richard; Sondericker, John; Sopko, Vit; Sopko, Bruno; Sosebee, Mark; Soukharev, Andrey; Spagnolo, Stefania; Spanò, Francesco; Spencer, Edwin; Spighi, Roberto; Spigo, Giancarlo; Spila, Federico; Spiwoks, Ralf; Spousta, Martin; Spreitzer, Teresa; Spurlock, Barry; St. Denis, Richard Dante; Stahl, Thorsten; Stahlman, Jonathan; Stamen, Rainer; Stancu, Stefan Nicolae; Stanecka, Ewa; Stanek, Robert; Stanescu, Cristian; Stapnes, Steinar; Starchenko, Evgeny; Stark, Jan; Staroba, Pavel; Starovoitov, Pavel; Stastny, Jan; Stavina, Pavel; Stavropoulos, Georgios; Steele, Genevieve; Steinbach, Peter; Steinberg, Peter; Stekl, Ivan; Stelzer, Bernd; Stelzer, Harald Joerg; Stelzer-Chilton, Oliver; Stenzel, Hasko; Stevenson, Kyle; Stewart, Graeme; Stockton, Mark; Stoerig, Kathrin; Stoicea, Gabriel; Stonjek, Stefan; Strachota, Pavel; Stradling, Alden; Straessner, Arno; Strandberg, Jonas; Strandberg, Sara; Strandlie, Are; Strauss, Michael; Strizenec, Pavol; Ströhmer, Raimund; Strom, David; Stroynowski, Ryszard; Strube, Jan; Stugu, Bjarne; Su, Dong; Soh, Dart-yin; Sugaya, Yorihito; Sugimoto, Takuya; Suhr, Chad; Suk, Michal; Sulin, Vladimir; Sultansoy, Saleh; Sumida, Toshi; Sun, Xiaohu; Sundermann, Jan Erik; Suruliz, Kerim; Sushkov, Serge; Susinno, Giancarlo; Sutton, Mark; Suzuki, Takuya; Suzuki, Yu; Sykora, Ivan; Sykora, Tomas; Szymocha, Tadeusz; Sánchez, Javier; Ta, Duc; Tackmann, Kerstin; Taffard, Anyes; Tafirout, Reda; Taga, Adrian; Takahashi, Yuta; Takai, Helio; Takashima, Ryuichi; Takeda, Hiroshi; Takeshita, Tohru; Talby, Mossadek; Talyshev, Alexey; Tamsett, Matthew; Tanaka, Junichi; Tanaka, Reisaburo; Tanaka, Satoshi; Tanaka, Shuji; Tapprogge, Stefan; Tardif, Dominique; Tarem, Shlomit; Tarrade, Fabien; Tartarelli, Giuseppe Francesco; Tas, Petr; Tasevsky, Marek; Tassi, Enrico; Tatarkhanov, Mous; Taylor, Christopher; Taylor, Frank; Taylor, Geoffrey; Taylor, Ryan P.; Taylor, Wendy; Teixeira-Dias, Pedro; Ten Kate, Herman; Teng, Ping-Kun; Tennenbaum-Katan, Yaniv-David; Terada, Susumu; Terashi, Koji; Terron, Juan; Terwort, Mark; Testa, Marianna; Teuscher, Richard; Thioye, Moustapha; Thoma, Sascha; Thomas, Juergen; Thompson, Stan; Thompson, Emily; Thompson, Peter; Thompson, Paul; Thompson, Ray; Thomson, Evelyn; Thun, Rudolf; Tic, Tomas; Tikhomirov, Vladimir; Tikhonov, Yury; Tipton, Paul; Tique Aires Viegas, Florbela De Jes; Tisserant, Sylvain; Toczek, Barbara; Todorov, Theodore; Todorova-Nova, Sharka; Toggerson, Brokk; Tojo, Junji; Tokár, Stanislav; Tokushuku, Katsuo; Tollefson, Kirsten; Tomasek, Lukas; Tomasek, Michal; Tomoto, Makoto; Tompkins, Lauren; Toms, Konstantin; Tonoyan, Arshak; Topfel, Cyril; Topilin, Nikolai; Torrence, Eric; Torró Pastor, Emma; Toth, Jozsef; Touchard, Francois; Tovey, Daniel; Trefzger, Thomas; Tremblet, Louis; Tricoli, Alesandro; Trigger, Isabel Marian; Trincaz-Duvoid, Sophie; Trinh, Thi Nguyet; Tripiana, Martin; Triplett, Nathan; Trischuk, William; Trivedi, Arjun; Trocmé, Benjamin; Troncon, Clara; Trzupek, Adam; Tsarouchas, Charilaos; Tseng, Jeffrey; Tsiakiris, Menelaos; Tsiareshka, Pavel; Tsionou, Dimitra; Tsipolitis, Georgios; Tsiskaridze, Vakhtang; Tskhadadze, Edisher; Tsukerman, Ilya; Tsulaia, Vakhtang; Tsung, Jieh-Wen; Tsuno, Soshi; Tsybychev, Dmitri; Tuggle, Joseph; Turecek, Daniel; Turk Cakir, Ilkay; Turlay, Emmanuel; Tuts, Michael; Twomey, Matthew Shaun; Tylmad, Maja; Tyndel, Mike; Uchida, Kirika; Ueda, Ikuo; Ugland, Maren; Uhlenbrock, Mathias; Uhrmacher, Michael; Ukegawa, Fumihiko; Unal, Guillaume; Undrus, Alexander; Unel, Gokhan; Unno, Yoshinobu; Urbaniec, Dustin; Urkovsky, Evgeny; Urquijo, Phillip; Urrejola, Pedro; Usai, Giulio; Uslenghi, Massimiliano; Vacavant, Laurent; Vacek, Vaclav; Vachon, Brigitte; Vahsen, Sven; Valente, Paolo; Valentinetti, Sara; Valkar, Stefan; Valladolid Gallego, Eva; Vallecorsa, Sofia; Valls Ferrer, Juan Antonio; Van Berg, Richard; van der Graaf, Harry; van der Kraaij, Erik; van der Poel, Egge; van der Ster, Daniel; van Eldik, Niels; van Gemmeren, Peter; van Kesteren, Zdenko; van Vulpen, Ivo; Vandelli, Wainer; Vaniachine, Alexandre; Vankov, Peter; Vannucci, Francois; Vari, Riccardo; Varnes, Erich; Varouchas, Dimitris; Vartapetian, Armen; Varvell, Kevin; Vasilyeva, Lidia; Vassilakopoulos, Vassilios; Vazeille, Francois; Vellidis, Constantine; Veloso, Filipe; Veneziano, Stefano; Ventura, Andrea; Ventura, Daniel; Venturi, Manuela; Venturi, Nicola; Vercesi, Valerio; Verducci, Monica; Verkerke, Wouter; Vermeulen, Jos; Vetterli, Michel; Vichou, Irene; Vickey, Trevor; Viehhauser, Georg; Villa, Mauro; Villani, Giulio; Villaplana Perez, Miguel; Vilucchi, Elisabetta; Vincter, Manuella; Vinek, Elisabeth; Vinogradov, Vladimir; Viret, Sébastien; Virzi, Joseph; Vitale , Antonio; Vitells, Ofer; Vivarelli, Iacopo; Vives Vaque, Francesc; Vlachos, Sotirios; Vlasak, Michal; Vlasov, Nikolai; Vogel, Adrian; Vokac, Petr; Volpi, Matteo; von der Schmitt, Hans; von Loeben, Joerg; von Radziewski, Holger; von Toerne, Eckhard; Vorobel, Vit; Vorwerk, Volker; Vos, Marcel; Voss, Rudiger; Voss, Thorsten Tobias; Vossebeld, Joost; Vranjes, Nenad; Vranjes Milosavljevic, Marija; Vrba, Vaclav; Vreeswijk, Marcel; Vu Anh, Tuan; Vudragovic, Dusan; Vuillermet, Raphael; Vukotic, Ilija; Wagner, Peter; Walbersloh, Jorg; Walder, James; Walker, Rodney; Walkowiak, Wolfgang; Wall, Richard; Wang, Chiho; Wang, Haichen; Wang, Jin; Wang, Song-Ming; Warburton, Andreas; Ward, Patricia; Warsinsky, Markus; Wastie, Roy; Watkins, Peter; Watson, Alan; Watson, Miriam; Watts, Gordon; Watts, Stephen; Waugh, Anthony; Waugh, Ben; Weber, Marc; Weber, Manuel; Weber, Michele; Weber, Pavel; Weidberg, Anthony; Weingarten, Jens; Weiser, Christian; Wellenstein, Hermann; Wells, Phillippa; Wen, Mei; Wenaus, Torre; Wendler, Shanti; Wengler, Thorsten; Wenig, Siegfried; Wermes, Norbert; Werner, Matthias; Werner, Per; Werth, Michael; Werthenbach, Ulrich; Wessels, Martin; Whalen, Kathleen; White, Andrew; White, Martin; White, Sebastian; Whitehead, Samuel Robert; Whiteson, Daniel; Whittington, Denver; Wicek, Francois; Wicke, Daniel; Wickens, Fred; Wiedenmann, Werner; Wielers, Monika; Wienemann, Peter; Wiglesworth, Craig; Wiik, Liv Antje Mari; Wildauer, Andreas; Wildt, Martin Andre; Wilkens, Henric George; Williams, Eric; Williams, Hugh; Willocq, Stephane; Wilson, John; Wilson, Michael Galante; Wilson, Alan; Wingerter-Seez, Isabelle; Winklmeier, Frank; Wittgen, Matthias; Wolter, Marcin Wladyslaw; Wolters, Helmut; Wosiek, Barbara; Wotschack, Jorg; Woudstra, Martin; Wraight, Kenneth; Wright, Catherine; Wright, Dennis; Wrona, Bozydar; Wu, Sau Lan; Wu, Xin; Wulf, Evan; Wynne, Benjamin; Xaplanteris, Leonidas; Xella, Stefania; Xie, Song; Xu, Da; Xu, Neng; Yamada, Miho; Yamamoto, Akira; Yamamoto, Kyoko; Yamamoto, Shimpei; Yamamura, Taiki; Yamaoka, Jared; Yamazaki, Takayuki; Yamazaki, Yuji; Yan, Zhen; Yang, Haijun; Yang, Un-Ki; Yang, Zhaoyu; Yao, Weiming; Yao, Yushu; Yasu, Yoshiji; Ye, Jingbo; Ye, Shuwei; Yilmaz, Metin; Yoosoofmiya, Reza; Yorita, Kohei; Yoshida, Riktura; Young, Charles; Youssef, Saul; Yu, Dantong; Yu, Jaehoon; Yuan, Li; Yurkewicz, Adam; Zaidan, Remi; Zaitsev, Alexander; Zajacova, Zuzana; Zambrano, Valentina; Zanello, Lucia; Zaytsev, Alexander; Zeitnitz, Christian; Zeller, Michael; Zemla, Andrzej; Zendler, Carolin; Zenin, Oleg; Ženiš, Tibor; Zenonos, Zenonas; Zenz, Seth; Zerwas, Dirk; Zevi della Porta, Giovanni; Zhan, Zhichao; Zhang, Huaqiao; Zhang, Jinlong; Zhang, Qizhi; Zhang, Xueyao; Zhao, Long; Zhao, Tianchi; Zhao, Zhengguo; Zhemchugov, Alexey; Zhong, Jiahang; Zhou, Bing; Zhou, Ning; Zhou, Yue; Zhu, Cheng Guang; Zhu, Hongbo; Zhu, Yingchun; Zhuang, Xuai; Zhuravlov, Vadym; Zimmermann, Robert; Zimmermann, Simone; Zimmermann, Stephanie; Ziolkowski, Michael; Živković, Lidija; Zobernig, Georg; Zoccoli, Antonio; zur Nedden, Martin; Zutshi, Vishnu

    2010-01-01

    The simulation software for the ATLAS Experiment at the Large Hadron Collider is being used for large-scale production of events on the LHC Computing Grid. This simulation requires many components, from the generators that simulate particle collisions, through packages simulating the response of the various detectors and triggers. All of these components come together under the ATLAS simulation infrastructure. In this paper, that infrastructure is discussed, including that supporting the detector description, interfacing the event generation, and combining the GEANT4 simulation of the response of the individual detectors. Also described are the tools allowing the software validation, performance testing, and the validation of the simulated output against known physics processes.

  11. ATLAS Jet Energy Scale

    CERN Document Server

    Schouten, D; Vetterli, M

    2012-01-01

    Jets originating from the fragmentation of quarks and gluons are the most common, and complicated, final state objects produced at hadron colliders. A precise knowledge of their energy calibration is therefore of great importance at experiments at the Large Hadron Collider at CERN, while is very difficult to ascertain. We present in-situ techniques and results for the jet energy scale at ATLAS using recent collision data. ATLAS has demonstrated an understanding of the necessary jet energy corrections to within \\approx 4% in the central region of the calorimeter.

  12. ATLAS/CMS Upgrades

    CERN Document Server

    AUTHOR|(INSPIRE)INSPIRE-00370685; The ATLAS collaboration

    2016-01-01

    Precision studies of the Standard Model (SM) and the searches of the physics beyond the SM are ongoing at the ATLAS and CMS experiments at the Large Hadron Collider (LHC). A luminosity upgrade of LHC is planned, which provides a significant challenge for the experiments. In this report, the plans of the ATLAS and CMS upgrades are introduced. Physics prospects for selected topics, including Higgs coupling measurements, Bs,d -> mumu decays, and top quark decays through flavor changing neutral current, are also shown.

  13. Cyberinfrastructure for the digital brain: spatial standards for integrating rodent brain atlases

    Directory of Open Access Journals (Sweden)

    Ilya eZaslavsky

    2014-09-01

    Full Text Available Biomedical research entails capture and analysis of massive data volumes and new discoveries arise from data-integration and mining. This is only possible if data can be mapped onto a common framework such as the genome for genomic data. In neuroscience, the framework is intrinsically spatial and based on a number of paper atlases. This cannot meet today’s data-intensive analysis and integration challenges. A scalable and extensible software infrastructure that is standards based but open for novel data and resources, is required for integrating information such as signal distributions, gene-expression, neuronal connectivity, electrophysiology, anatomy, and developmental processes. Therefore, the International Neuroinformatics Coordinating Facility (INCF initiated the development of a spatial framework for neuroscience data integration with an associated Digital Atlasing Infrastructure (DAI. A prototype implementation of this infrastructure for the rodent brain is reported here. The infrastructure is based on a collection of reference spaces to which data is mapped at the required resolution, such as the Waxholm Space (WHS, a 3D reconstruction of the brain generated using high-resolution, multi-channel microMRI. The core standards of the digital atlasing service-oriented infrastructure include Waxholm Markup Language (WaxML: XML schema expressing a uniform information model for key elements such as coordinate systems, transformations, points of interest (POIs, labels, and annotations; and Atlas Web Services: interfaces for querying and updating atlas data. The services return WaxML-encoded documents with information about capabilities, spatial reference systems and structures, and execute coordinate transformations and POI-based requests. Key elements of INCF-DAI cyberinfrastructure have been prototyped for both mouse and rat brain atlas sources, including the Allen Mouse Brain Atlas, UCSD Cell-Centered Database, and Edinburgh Mouse Atlas

  14. Performance of the ATLAS Liquid Argon Calorimeter After Three Years of LHC Operation and Plans for a Future Upgrade

    CERN Document Server

    Ilic, N; The ATLAS collaboration

    2013-01-01

    The ATLAS experiment is a multi-purpose detector built for analyzing LHC collision data. In July 2012, ATLAS announced the discovery of the Higgs boson, the last undiscovered particle in the Standard Model of particle physics. The ATLAS Liquid Argon (LAr) Calorimeter played a crucial role in the discovery by providing accurate measurements of Higgs final states such as photons, electrons and jets. The LAr detector is a sampling calorimeter consisting of four subsystems: an electromagnetic barrel (EMB), electromagnetic end-caps (EMEC), hadronic end-caps (HEC), and forward calorimeters (FCAL). The liquid argon purity, temperature and time stability remained well above the required levels throughout the data-taking period. Overall the calorimeter performed very well, with over 99% of data it collected in 2012 proton-proton collisions being suitable for physics analysis. In order to maintain good LAr detector performance, several upgrades are currently being implemented and planned.

  15. The Greatest Mathematical Discovery?

    Energy Technology Data Exchange (ETDEWEB)

    Bailey, David H.; Borwein, Jonathan M.

    2010-05-12

    What mathematical discovery more than 1500 years ago: (1) Is one of the greatest, if not the greatest, single discovery in the field of mathematics? (2) Involved three subtle ideas that eluded the greatest minds of antiquity, even geniuses such as Archimedes? (3) Was fiercely resisted in Europe for hundreds of years after its discovery? (4) Even today, in historical treatments of mathematics, is often dismissed with scant mention, or else is ascribed to the wrong source? Answer: Our modern system of positional decimal notation with zero, together with the basic arithmetic computational schemes, which were discovered in India about 500 CE.

  16. 17 April 2008 - Head of Internal Audit Network meeting visiting the ATLAS experimental area with CERN ATLAS Team Leader P. Fassnacht, ATLAS Technical Coordinator M. Nessi and ATLAS Resources Manager M. Nordberg.

    CERN Multimedia

    Mona Schweizer

    2008-01-01

    17 April 2008 - Head of Internal Audit Network meeting visiting the ATLAS experimental area with CERN ATLAS Team Leader P. Fassnacht, ATLAS Technical Coordinator M. Nessi and ATLAS Resources Manager M. Nordberg.

  17. ATLAS Civil Engineering Point 1

    CERN Multimedia

    Jean-Claude Vialis

    2000-01-01

    Different phases of realisation to Point 1 : zone of the ATLAS experiment The ATLAS experimental area is located in Point 1, just across the main CERN entrance, in the commune of Meyrin. There people are ever so busy to finish the different infrastructures for ATLAS. Real underground video. When passing throw the walls the succeeding can be heard and seen. The film has original working sound.

  18. The discovery of the Higgs boson at the Large Hadron Collider

    Science.gov (United States)

    Nisati, A.; Tonelli, G.

    2015-11-01

    This paper summarises the work done by the ATLAS and CMS collaborations, and by the teams of the Large Hadron Collider at CERN, that led to the discovery of a new particle, with mass near 125GeV and properties consistent with the ones predicted for the Standard Model Higgs boson. An overview of the Standard Model, with a description of the role of the Higgs boson in the theory, and a summary of the searches for this particle prior to the LHC operations is also given. The paper presents the results obtained by ATLAS and CMS from the analysis of the full data set produced in the first physics run of LHC. After a short discussion on the implications of the discovery, the future prospects for the precision study of the new particle are lastly discussed.

  19. Toxins and drug discovery.

    Science.gov (United States)

    Harvey, Alan L

    2014-12-15

    Components from venoms have stimulated many drug discovery projects, with some notable successes. These are briefly reviewed, from captopril to ziconotide. However, there have been many more disappointments on the road from toxin discovery to approval of a new medicine. Drug discovery and development is an inherently risky business, and the main causes of failure during development programmes are outlined in order to highlight steps that might be taken to increase the chances of success with toxin-based drug discovery. These include having a clear focus on unmet therapeutic needs, concentrating on targets that are well-validated in terms of their relevance to the disease in question, making use of phenotypic screening rather than molecular-based assays, and working with development partners with the resources required for the long and expensive development process. PMID:25448391

  20. Leadership and Discovery

    CERN Document Server

    Goethals, George R

    2009-01-01

    This book, a collection of essays from scholars across disciplines, explores leadership of discovery, probing the guided and collaborative exploration and interpretation of the experience of our inner thoughts and feelings, and of our external worlds

  1. Fateful discovery almost forgotten

    CERN Multimedia

    1989-01-01

    "The discovery of the fission of uranium exactly half a century ago is at risk of passing unremarked because of the general ambivalence towards the consequences of this development. Can that be wise?" (4 pages)

  2. Discovery Driven Growth

    DEFF Research Database (Denmark)

    Bukh, Per Nikolaj

    2009-01-01

    Anmeldelse af Discovery Driven Growh : A breakthrough process to reduce risk and seize opportunity, af Rita G. McGrath & Ian C. MacMillan, Boston: Harvard Business Press. Udgivelsesdato: 14 august......Anmeldelse af Discovery Driven Growh : A breakthrough process to reduce risk and seize opportunity, af Rita G. McGrath & Ian C. MacMillan, Boston: Harvard Business Press. Udgivelsesdato: 14 august...

  3. Electromagnetic calorimeter and accurate measurement with the ATLAS detector of the LHC collider; Calorimetrie electromagnetique et mesures de precision avec le detecteur ATLAS aupres du collisionneur LHC

    Energy Technology Data Exchange (ETDEWEB)

    Pralavorio, P

    2007-06-15

    The main purpose of the ATLAS experiment is the understanding of the underlying mechanisms that drive the breaking of the electro-weak symmetry through the discovery of Higgs bosons. An important element to achieve this aim was the design of an electromagnetic calorimeter able to investigate the decay channels: H {yields} {gamma}{gamma} and H {yields} 4e. The high performance of the calorimeter will allow us to get a better accuracy on the measuring values of W and top masses which is essential to indirectly constrain the mass of the Higgs. In the same way, accurate measurements of top and W properties during the decays of top and tWb vertex will be necessary to question the standard model and to see beyond. The author has been working for 9 years in the ATLAS project, he has been involved in the design, construction, qualification and testing phases of the electromagnetic calorimeter of ATLAS. This document is a detailed presentation of the calorimeter, of its qualification and of its expectations when LHC is operating. This document is organized into 4 chapters: 1) assets and weaknesses of the standard model, 2) the ATLAS experiment, 3) the electromagnetic calorimeter, and 4) accurate measurements with ATLAS. This document presented before an academic board will allow its author to manage research works and particularly to tutor thesis students. (A.C.)

  4. Taking ATLAS to new heights

    CERN Multimedia

    Abha Eli Phoboo, ATLAS experiment

    2013-01-01

    Earlier this month, 51 members of the ATLAS collaboration trekked up to the highest peak in the Atlas Mountains, Mt. Toubkal (4,167m), in North Africa.    The physicists were in Marrakech, Morocco, attending the ATLAS Overview Week (7 - 11 October), which was held for the first time on the African continent. Around 300 members of the collaboration met to discuss the status of the LS1 upgrades and plans for the next run of the LHC. Besides the trek, 42 ATLAS members explored the Saharan sand dunes of Morocco on camels.  Photos courtesy of Patrick Jussel.

  5. Scientific Discoveries: What Is Required for Lasting Impact.

    Science.gov (United States)

    Lømo, Terje

    2016-01-01

    I have been involved in two scientific discoveries of some impact. One is the discovery of long-term potentiation (LTP), the phenomenon that brief, high-frequency impulse activity at synapses in the brain can lead to long-lasting increases in their efficiency of transmission. This finding demonstrated that synapses are plastic, a property thought to be necessary for learning and memory. The other discovery is that nerve-evoked muscle impulse activity, rather than putative trophic factors, controls the properties of muscle fibers. Here I describe how these two discoveries were made, the unexpected difficulties of reproducing the first discovery, and the controversies that followed the second discovery. I discuss why the first discovery took many years to become generally recognized, whereas the second caused an immediate sensation and entered textbooks and major reviews but is now largely forgotten. In the long run, discovering a new phenomenon has greater impact than falsifying a popular hypothesis. PMID:26273911

  6. Atlas of NATO.

    Science.gov (United States)

    Young, Harry F.

    This atlas provides basic information about the North Atlantic Treaty Organization (NATO). Formed in response to growing concern for the security of Western Europe after World War II, NATO is a vehicle for Western efforts to reduce East-West tensions and the level of armaments. NATO promotes political and economic collaboration as well as military…

  7. Higgs searches with ATLAS

    CERN Document Server

    Price, J D; The ATLAS collaboration

    2013-01-01

    Summary of the ATLAS analyses for the rarer SM Higgs decay channels, and the limits of the SM Higgs invisible decay width. Analyses included are the VH->Vbb, H->tautau, VH->VWW, H->Zy, H->mumu, ttH->ttyy and ZH->ll+inv.

  8. HWW in ATLAS

    CERN Document Server

    Rados, Pere; The ATLAS collaboration

    2016-01-01

    The H-->WW channel plays an important role in Higgs boson property measurements, searches for rare decay modes, and searches for possible extended Higgs sectors. In this talk the latest H-->WW results from ATLAS will be briefly summarised.

  9. Exotic searches at ATLAS

    CERN Document Server

    Turra, Ruggero; The ATLAS collaboration

    2016-01-01

    The ATLAS detector has collected 3.2 fb^-1 of proton-proton collisions at 13 TeV centre of mass energy during the 2015 LHC run. A selected review of the recent result are presented in the context of the direct search for BSM, not SUSY, not BSM Higgs.

  10. ATLAS starts moving in

    CERN Multimedia

    2004-01-01

    The first large active detector component was lowered into the ATLAS cavern on 1 March. It consisted of the 8 modules forming the lower part of the central barrel of the tile hadronic calorimeter. The work of assembling the barrel, which comprises 64 modules, started the following day.

  11. A thermosiphon for ATLAS

    CERN Multimedia

    Rosaria Marraffino

    2013-01-01

    A new thermosiphon cooling system, designed for the ATLAS silicon detectors by CERN’s EN-CV team in collaboration with the experiment, will replace the current system in the next LHC run in 2015. Using the basic properties of density difference and making gravity do the hard work, the thermosiphon promises to be a very reliable solution that will ensure the long-term stability of the whole system.   Former compressor-based cooling system of the ATLAS inner detectors. The system is currently being replaced by the innovative thermosiphon. (Photo courtesy of Olivier Crespo-Lopez). Reliability is the major issue for the present cooling system of the ATLAS silicon detectors. The system was designed 13 years ago using a compressor-based cooling cycle. “The current cooling system uses oil-free compressors to avoid fluid pollution in the delicate parts of the silicon detectors,” says Michele Battistin, EN-CV-PJ section leader and project leader of the ATLAS thermosiphon....

  12. ATLAS solenoid operates underground

    CERN Multimedia

    2006-01-01

    A new phase for the ATLAS collaboration started with the first operation of a completed sub-system: the Central Solenoid. Teams monitoring the cooling and powering of the ATLAS solenoid in the control room. The solenoid was cooled down to 4.5 K from 17 to 23 May. The first current was established the same evening that the solenoid became cold and superconductive. 'This makes the ATLAS Central Solenoid the very first cold and superconducting magnet to be operated in the LHC underground areas!', said Takahiko Kondo, professor at KEK. Though the current was limited to 1 kA, the cool-down and powering of the solenoid was a major milestone for all of the control, cryogenic, power and vacuum systems-a milestone reached by the hard work and many long evenings invested by various teams from ATLAS, all of CERN's departments and several large and small companies. Since the Central Solenoid and the barrel liquid argon (LAr) calorimeter share the same cryostat vacuum vessel, this achievement was only possible in perfe...

  13. Prototype ATLAS straw tracker

    CERN Multimedia

    Laurent Guiraud

    1998-01-01

    This is an early prototype of the straw tracking device for the ATLAS detector at CERN. This detector will be part of the LHC project, scheduled to start operation in 2008. The straw tracker will consist of thousands of gas-filled straws, each containing a wire, allowing the tracks of particles to be followed.

  14. ATLAS "Splash event" 2008

    CERN Multimedia

    ATLAS, Experiment

    2014-01-01

    "Splash events": As the LHC was being tuned up on 10 September 2008, beam was initially directed at beam collimators just outside the detector, so that a splash of particles would fill much of the detector allowing ATLAS experimenters to prepare the detector for actual running.

  15. Prime wires for ATLAS

    CERN Multimedia

    2003-01-01

    In an award ceremony on 3 September, ATLAS honoured the French company Axon Cable for its special coaxial cables, which were purpose-built for the Liquid Argon calorimeter modules. Working for CERN since the 1970s, Axon' Cable received the ATLAS supplier award last week for its contribution to the liquid argon calorimeter cables of ATLAS (LAL/Orsay, France and University of Victoria, Canada), started in 1996. Its two sets of minicoaxial cables, called harnesses "A" and "B", are designed to function in the harsh conditions in the liquid argon (at 90 Kelvin or -183°C) and under extreme radiation (up to several Mrads). The cables are mainly used for the readout of the calorimeters, and are connected to the outside world by 114 signal feedthroughs with 1920 channels each. The signal from the detectors is transmitted directly without any amplification, which imposes tight restrictions on the impedance and on the signal propagation time of the cables. Peter Jenni, ATLAS spokesperson, gives the award for best s...

  16. Potential targets for lung squamous cell carcinoma

    Science.gov (United States)

    Researchers have identified potential therapeutic targets in lung squamous cell carcinoma, the second most common form of lung cancer. The Cancer Genome Atlas (TCGA) Research Network study comprehensively characterized the lung squamous cell carcinoma gen

  17. Event reconstruction algorithms for the ATLAS trigger

    CERN Document Server

    Fonseca-Martin, T; Adragna, P; Aleksandrov, E; Aleksandrov, I; Amorim, A; Anderson, K; Anduaga, X; Aracena, I; Asquith, L; Avolio, G; Backlund, S; Badescu, E; Baines, J; Barria, P; Bartoldus, R; Batreanu, S; Beck, H P; Bee, C; Bell, P; Bell, W H; Bellomo, M; Benslama, K; Berge, D; Berger, N; Berry, T; Biglietti, M; Blair, R R; Bogaerts, A; Bold, T; Bosman, M; Boyd, J; Brelier, B; Burckhart-Chromek, D; Buttar, C; Campanelli, M; Caprini, M; Carlino, G; Casadei, D; Casado, M P; Cataldi, G; Cimino, D; Ciobotaru, M; Clements, D; Coccaro, A; Conde-Muíño, P; Conventi, F; Corso-Radu, A; Costa, M J; Coura Torres, R; Cranfeld, R; Cranmer, K; Crone, G; Dam, M; Damazio, D; Dawson, I; Dawson, J; De Almeida Simoes, J; De Cecco, S; De Santo, A; DellaPietra, M; Delsart, P A; Demers, S; Demirkoz, B; Di Mattia, A; Dionisi, C; Djilkibaev, R; Dobinson, R; Dobson, M; Dotti, A; Dova, M; Drake, G; Dufour, M A; Eckweiler, S; Ehrenfeld, W; Eifert, T; Ellis, Nick; Emeliyanov, D; Enoque Ferreira de Lima, D; Ermoline, Y; Eschrich, I; Facius, K; Falciano, S; Farthouat, P; Feng, E; Ferland, J; Ferrari, R; Ferrer, M L; Fischer, G; Francis, D; Gadomski, S; Garitaonandia Elejabarrieta, H; Gaudio, G; Gaumer, O; George, S; Giagu, S; Goncalo, R; Gorini, B; Gorini, E; Gowdy, S; Grabowska-Bold, I; Grancagnolo, S; Green, B; Haas, S; Haberichter, W; Hadavand, H; Haeberli, C; Haller, J; Hamilton, A; Hansen, J R; Hauschild, M; Hauser, R; Head, S; Hillier, S J; Höcker, A; Hrynóva, T; Hughes-Jones, R; Huston, J; Idarraga, J; Igonkina, O; Inada, M; Jain, V; Johns, K; Joos, M; Kama, S; Kanaya, N; Kazarov, A; Kehoe, R; Khoriauli, G; Kieft, G; Kilvington, G; Kirk, J; Kiyamura, H; Kolos, S; Kono, T; Konstantinidis, N; Korcyl, K; Kordas, K; Kotov, V; Krasznahorkay, A; Kubota, T; Kugel, A; Kuhn, D; Kurasige, H; Kuwabara, T; Kwee, R; Lankford, A; LeCompte, T; Leahu, L; Leahu, M; Ledroit, F; Lehmann-Miotto, G; Lei, X; Lellouch, D; Leyton, M; Li, S; Lim, H; Lohse, T; Losada, M; Luci, C; Luminari, L; Mapelli, L; Martin, B; Martin, B T; Marzano, F; Masik, J; McMahon, T; McPherson, R; Medinnis, M; Meessen, C; Meirosu, C; Messina, A; Mincer, A; Mineev, M; Misiejuk, A; Mönig, K; Monticelli, F; Moraes, A; Moreno, D; Morettini, P; Murillo Garcia, R; Nagano, K; Nagasaka, Y; Negri, A; Némethy, P; Neusiedl, A; Nisati, A; Nozicka, M; Omachi, C; Osculati, B; Osuna, C; Padilla, C; Panikashvili, N; Parodi, F; Pasqualucci, E; Pauly, T; Perera, V; Pérez, E; Pérez-Réale, V; Petersen, J; Piegaia, R; Pilcher, J E; Pinzon, G; Pope, B; Potter, C; Primavera, M; Radescu, V; Rajagopalan, S; Renkel, P; Rescigno, M; Rieke, S; Risler, C; Riu, I; Robertson, S; Roda, C; Rodríguez, D; Rogriquez, Y; Ryabov, Yu; Ryan, P; Salvatore, D; Santamarina, C; Santamarina-Rios, C; Scannicchio, D; Scannicchio, D A; Schiavi, C; Schlereth, J L; Scholtes, I; Schooltz, D; Scott, W; Segura, E; Shimbo, N; Sidoti, A; Siragusa, G; Sivoklokov, S; Sloper, J E; Smizanska, M; Soloviev, I; Soluk, R; Spagnolo, S; Spiwoks, R; Stancu, S; Steinberg, P; Stelzer, J; Stradling, A; Strom, David M; Strong, J; Su, D; Sushkov, S; Sutton, M; Szymocha, T; Tapprogge, S; Tarem, S; Tarem, Z; Teixeira-Dias, P; Tokoshuku, K; Torrence, E; Touchard, F; Tremblet, L; Tripiana, M; Usai, G; Vachon, B; Vandelli, W; Ventura, A; Vercesi, V; Vermeulen, J; Von Der Schmitt, J; Wang, M; Watson, A; Wengler, T; Werner, P; Wheeler-Ellis, S; Wickens, F; Wiedenmann, W; Wielers, M; Wilkens, H; Winklmeier, F; Woerling, E E; Wu, S L; Wu, X; Xella, S; Yamazaki, Y; Yu, M; Zema, F; Zhang, J; Zhao, L; Zobernig, H; Dos Anjos, A; Zur Nedden, M; Ozcan, E; Ünel, G

    2008-01-01

    The ATLAS experiment under construction at CERN is due to begin operation at the end of 2007. The detector will record the results of proton-proton collisions at a center-of-mass energy of 14 TeV. The trigger is a three-tier system designed to identify in real-time potentially interesting events that are then saved for detailed offline analysis. The trigger system will select approximately 200 Hz of potentially interesting events out of the 40 MHz bunch-crossing rate (with 109 interactions per second at the nominal luminosity).

  18. Virtual Visit to the ATLAS Control Room by Europe Day Symposium

    CERN Multimedia

    2013-01-01

    EUROPE DAY 2013: A Symposium Examining Canada/European Scientific Collaboration On May 9 2013. Canadians in Vancouver, British Columbia, will be gathering to enrich their understanding of scientific collaboration between Canada and Europe using CERN and its recent discovery of the Higgs boson as a framework for a symposium celebrating Europe Day. Canadians have been involved in nearly every aspect of the Large Hadron Collider accelerator and the ATLAS particle-physics detector. ATLAS-Canada spokesperson Rob McPherson will be addressing the symposium participants and talking about the multi-national effort that led to the Higgs breakthrough; his presentation will include a live virtual visit to the ATLAS control room at CERN. The event is hosted by TRIUMF, Canada`s national laboratory for particle and nuclear physics. http://www.europeanfestival.ca/europe-day

  19. ATLAS@Home: Harnessing Volunteer Computing for HEP

    CERN Document Server

    Cameron, David; The ATLAS collaboration

    2015-01-01

    The ATLAS collaboration has setup a volunteer computing project called ATLAS@home. Volunteers running Monte-Carlo simulation on their personal computer provide significant computing resources, but also belong to a community potentially interested in HEP. Four types of contributors have been identified, whose questions range from advanced technical details to the reason why simulation is needed, how Computing is organized and how it relates to society. The creation of relevant outreach material for simulation, event visualization and distributed production will be described, as well as lessons learned while interacting with the BOINC volunteers community.

  20. Wind Atlas of Aegean Sea with SAR data

    DEFF Research Database (Denmark)

    Bingöl, Ferhat; Hasager, Charlotte Bay; Badger, Merete;

    2013-01-01

    The Global Wind Atlas project is established to create a “free-to-use” wind atlas of the whole globe. The modelling chain of the project includes micro-scale models and new reanalysis datasets. Local measurements are planed to be use for test and validation. Unfortunately, it is not always possible...... satellite radar technologies made it possible to use Synthetic Aperture Radars (SAR) for wind speed and direction measurements at offshore locations. In this study, a new technique of making wind atlases is applied to the region of Aegean Sea is presented. The method has been tested and validated in the...... to find long term offshore measurement to make wind statistics. The main reason is the cost of setup and maintenance of an offshore mast. One of the regions which has high potential in wind resources but so far is without any long term offshore measurement is the Aegean sea. Recent developments in...

  1. ATLAS Experience with HEP Software at the Argonne Leadership Computing Facility

    CERN Document Server

    LeCompte, T; The ATLAS collaboration; Benjamin, D

    2014-01-01

    A number of HEP software packages used by the ATLAS experiment, including GEANT4, ROOT and ALPGEN, have been adapted to run on the IBM Blue Gene supercomputers at the Argonne Leadership Computing Facility. These computers use a non-x86 architecture and have a considerably less rich operating environment than in common use in HEP, but also represent a computing capacity an order of magnitude beyond what ATLAS is presently using via the LCG. The status and potential for making use of leadership-class computing, including the status of integration with the ATLAS production system, is discussed.

  2. Performance of the reconstruction, calibration and identification of electrons and photons with the ATLAS detector

    CERN Document Server

    Heim, Sarah; The ATLAS collaboration

    2016-01-01

    The performance of the reconstruction, calibration and identification of electrons and photons with the ATLAS detector at the LHC is a key component to realize the ATLAS full physics potential, both in the searches for new physics and in precision measurements. Updates to the algorithms used for the reconstruction and identification of electrons and photons with the ATLAS detector during LHC run 2 are presented. Measurements of the identification efficiencies are derived from data. The results from the 2015 and partial 2016 $pp$ collision data set at $\\sqrt{s}$ = 13 TeV are reported. Improvements to the electron and photon energy calibration procedure and its performance are also discussed.

  3. ATLAS experience with HEP software at the Argonne leadership computing facility

    International Nuclear Information System (INIS)

    A number of HEP software packages used by the ATLAS experiment, including GEANT4, ROOT and ALPGEN, have been adapted to run on the IBM Blue Gene supercomputers at the Argonne Leadership Computing Facility. These computers use a non-x86 architecture and have a considerably less rich operating environment than in common use in HEP, but also represent a computing capacity an order of magnitude beyond what ATLAS is presently using via the LCG. The status and potential for making use of leadership-class computing, including the status of integration with the ATLAS production system, is discussed.

  4. The Education and Outreach Project of ATLAS - A New Participant in Physics Education

    International Nuclear Information System (INIS)

    The ATLAS experiment at the Large Hadron Collider at CERN has a substantial collaborative Education and Outreach project. This article describes its activities and how it promotes physics to students around the world. With the extraordinary possibility to make groundbreaking discoveries, the ATLAS Experiment [1] at the Large Hadron Collider at CERN can play an important role in promoting contemporary physics at school. For many years ATLAS has had a substantial collaborative Education and Outreach (E and O) project in which physicists from various parts of the world take part. When the experiment begins in 2007, students from around the world will be analyzing data using cutting-edge technology. The unprecedented collision energies of the Large Hadron Collider allow ATLAS to decode the 'events' that unfold after the head-on collisions of protons (Fig. 1). The scientific results from these events will reveal much about the basic nature of matter, energy, space, and time. Students and others will be excited as they try to find events that may be signs for dark matter, extra dimensions of space, mini-black holes, string theory, and other fundamental discoveries. Science education and outreach and the promotion of awareness and appreciation of physics research have become important tasks for the research community and should be recognized as a natural and logical part of science research and as an important link between research and society. To be successful these activities have to be done in a systematic and professional way. Leading scientists together with multimedia experts can form a powerful team with teachers and educators in disseminating physics information to school and universities. The ATLAS collaboration has fully recognized the importance of education and outreach. The ATLAS E and O project can be a model for today's large science experiments in promoting science at schools and universities

  5. Graph-Based Methods for Discovery Browsing with Semantic Predications

    OpenAIRE

    Wilkowski, Bartlomiej; Fiszman, Marcelo; Miller, Christopher M.; Hristovski, Dimitar; Arabandi, Sivaram; Rosemblat, Graciela; Rindflesch, Thomas C.

    2011-01-01

    We present an extension to literature-based discovery that goes beyond making discoveries to a principled way of navigating through selected aspects of some biomedical domain. The method is a type of “discovery browsing” that guides the user through the research literature on a specified phenomenon. Poorly understood relationships may be explored through novel points of view, and potentially interesting relationships need not be known ahead of time. In a process of “cooperative reciprocity” t...

  6. A Decade of Discovery

    Energy Technology Data Exchange (ETDEWEB)

    None

    2008-01-01

    This book provides a fascinating account of some of the most significant scientific discoveries and technological innovations coming out of the U.S. Department of Energy’s National Laboratories. This remarkable book illustrates how the men and women of the National Laboratories are keeping us on the cutting edge. Though few Americans are familiar with the scope and scale of the work conducted at these National Laboratories, their research is literally changing our lives and bettering our planet. The book describes the scientific discoveries and technological advancements "in recognition of the men and women working in DOE's seventeen national laboratories across the country." Through highly vivid and accessible stories, this book details recent breakthroughs in three critical areas: 1) Energy and Environment, 2) National Security and 3) Life and Physical Science. The book illustrates how this government-funded research has resulted in more energy-efficient buildings; new, cleaner alternative fuels that reduce greenhouse gas emissions; safer, more efficient, nuclear power plants; improved responses to disease outbreaks; more secure and streamlined airport security; more effective treatments for cancer and other diseases; and astonishing discoveries that are altering our understanding of the universe and enabling scientific breakthroughs in fields such as nanotechnology and particle physics. Specifically, it contains 37 stories. A Decade of Discovery is truly a recent history of discovery - and a fascinating look at what the next decade holds.

  7. Improving atlas methodology

    Science.gov (United States)

    Robbins, C.S.; Dowell, B.A.; O'Brien, J.

    1987-01-01

    We are studying a sample of Maryland (2 %) and New Hampshire (4 %) Atlas blocks and a small sample in Maine. These three States used different sampling methods and block sizes. We compare sampling techniques, roadside with off-road coverage, our coverage with that of the volunteers, and different methods of quantifying Atlas results. The 7 1/2' (12-km) blocks used in the Maine Atlas are satisfactory for coarse mapping, but are too large to enable changes to be detected in the future. Most states are subdividing the standard 7 1/2' maps into six 5-km blocks. The random 1/6 sample of 5-km blocks used in New Hampshire, Vermont (published 1985), and many other states has the advantage of permitting detection of some changes in the future, but the disadvantage of leaving important habitats unsampled. The Maryland system of atlasing all 1,200 5-km blocks and covering one out of each six by quarterblocks (2 1/2-km) is far superior if enough observers can be found. A good compromise, not yet attempted, would be to Atlas a 1/6 random sample of 5-km blocks and also one other carefully selected (non-random) block on the same 7 1/2' map--the block that would include the best sample of habitats or elevations not in the random block. In our sample the second block raised the percentage of birds found from 86% of the birds recorded in the 7 1/2' quadrangle to 93%. It was helpful to list the expected species in each block and to revise this list annually. We estimate that 90-100 species could be found with intensive effort in most Maryland blocks; perhaps 95-105 in New Hampshire. It was also helpful to know which species were under-sampled so we could make a special effort to search for these. A total of 75 species per block (or 75% of the expected species in blocks with very restricted habitat diversity) is considered a practical and adequate goal in these States. When fewer than 60 species are found per block, a high proportion of the rarer species are missed, as well as some of

  8. ATLAS: civil engineering Point 1

    CERN Multimedia

    2000-01-01

    The ATLAS experimental area is located in Point 1, just across the main CERN entrance, in the commune of Meyrin. There people are busy to finish the different infrastructures for ATLAS. Real underground video. Nice view from the surface to the cavern from the pit side - all the big machines looked very small. The film has original working sound.

  9. The ATLAS Forward Physics Program

    OpenAIRE

    Royon, Christophe

    2010-01-01

    We describe the ATLAS Forward Physics Program at low luminosity using the rapidity gap method and a dedicated detector called ALFA to tag the protons. We also describe the physics topics of the ATLAS Forward Physics Project at high instantaneous luminosity.

  10. ATLAS recognises its best suppliers

    CERN Multimedia

    2002-01-01

    The ATLAS Collaboration has recently rewarded two of its suppliers in the construction of very major detector components, fabricated in Japan. The ATLAS Supplier Award in recognition of excellent supplier performance has just been attributed to Kawasaki Heavy Industries, while Toshiba Corporation received the award two months ago at their headquarters in Japan.

  11. Lowering the first ATLAS toroid

    CERN Multimedia

    Maximilien Brice

    2004-01-01

    The ATLAS detector on the LHC at CERN will consist of eight toroid magnets, the first of which was lowered into the cavern in these images on 26 October 2004. The coils are supported on platforms where they will be attached to form a giant torus. The platforms will hold about 300 tonnes of ATLAS' muon chambers and will envelop the inner detectors.

  12. ATLAS end-cap detector

    CERN Multimedia

    Maximilien Brice

    2003-01-01

    Three scientists from the Institute of Nuclear Phyiscs at Novossibirsk with one of the end-caps of the ATLAS detector. The end-caps will be used to detect particles produced in the proton-proton collisions at the heart of the ATLAS experiment that are travelling close to the axis of the two beams.

  13. Mise en service du calorimetre electromagnetique d'Atlas et determination du potentiel de decouverte d'un Z' --> e+e- dans les premieres donnees LHC

    CERN Document Server

    Mangeard, Pierre-Simon

    2009-01-01

    After about fifteen years of development, the ATLAS detector is ready to operate and recorded, in 2008, several millions of cosmic events as well as first LHC data. This achievement is based on the long experience of beam tests and on the large effort towards the detector in situ commissioning undertaken by the ATLAS collaboration. This promises fast ability to perform searches for evidence of Higgs boson and new physics. I heavily contributed to the in situ commissioning of the EM calorimeter. To verify its performance, I studied the first cosmic data taken in 2006 which allowed the first in situ analysis of dead channels, energy reconstruction and detector response uniformity. This participation to the commissioning has continued with the study of the single beam data recorded during the first week of LHC operation (Sept. 2008). Expanding on my expertise of the EM calorimeter, I focused my physics analysis, prepared with simulation, on the promising discovery potential of new physics at LHC via the di-elect...

  14. Brain templates and atlases.

    Science.gov (United States)

    Evans, Alan C; Janke, Andrew L; Collins, D Louis; Baillet, Sylvain

    2012-08-15

    The core concept within the field of brain mapping is the use of a standardized, or "stereotaxic", 3D coordinate frame for data analysis and reporting of findings from neuroimaging experiments. This simple construct allows brain researchers to combine data from many subjects such that group-averaged signals, be they structural or functional, can be detected above the background noise that would swamp subtle signals from any single subject. Where the signal is robust enough to be detected in individuals, it allows for the exploration of inter-individual variance in the location of that signal. From a larger perspective, it provides a powerful medium for comparison and/or combination of brain mapping findings from different imaging modalities and laboratories around the world. Finally, it provides a framework for the creation of large-scale neuroimaging databases or "atlases" that capture the population mean and variance in anatomical or physiological metrics as a function of age or disease. However, while the above benefits are not in question at first order, there are a number of conceptual and practical challenges that introduce second-order incompatibilities among experimental data. Stereotaxic mapping requires two basic components: (i) the specification of the 3D stereotaxic coordinate space, and (ii) a mapping function that transforms a 3D brain image from "native" space, i.e. the coordinate frame of the scanner at data acquisition, to that stereotaxic space. The first component is usually expressed by the choice of a representative 3D MR image that serves as target "template" or atlas. The native image is re-sampled from native to stereotaxic space under the mapping function that may have few or many degrees of freedom, depending upon the experimental design. The optimal choice of atlas template and mapping function depend upon considerations of age, gender, hemispheric asymmetry, anatomical correspondence, spatial normalization methodology and disease

  15. The Higgs as a portal to the hidden sector via an analysis of $H\\to Zd_d Z_d \\to 4l$ using the ATLAS detector

    CERN Document Server

    Unwuchola, D A

    2015-01-01

    The Standard Model (SM) has well known deciencies, and there is clearly need for new physics beyond the SM. The particles manifesting the new physics would interact at most weakly with the SM particles, and hence they are termed dark. The Higgs boson is potentially a favourable route for the production of the dark particles. There are a large class of theories where couplings or mixings at the Higgs level leads to exotic Higgs decays, which nonetheless do not signicantly disturb the known physics below the Higgs level. This is therefore a signicant potential discovery opportunity. We present the motivation and progress made in the studies which have been carried out as part of designing the search for the exotic decay of the SM Higgs which proceeds via a dark force back to SM four leptons, H $\\to$ Z$_d$Z$_d$ $\\to$ 4l from the LHC run 1 data using the ATLAS detector.

  16. ATLAS DQ2 DELETION SERVICE

    CERN Document Server

    Oleynik, D; The ATLAS collaboration; Garonne, V; Campana, S

    2012-01-01

    ATLAS DQ2 Deletion service is a sub system of the ATLAS Distributed Data Management (DDM) project DQ2. DDM DQ2 responsible for the replication, access and bookkeeping of ATLAS data across more than 130 distributed grid sites. It also enforces data management policies decided on by the collaboration and defined in the ATLAS computing model. Responsibility of ATLAS DQ2 Deletion service is serving deletion requests on the grid by interacting with grid middleware and the DQ2 catalogues. Furthermore, it also takes care of retry strategies, check-pointing transactions, load management and fault tolerance. In this talk special attention is paid to the technical details, which are used to achieve the high performance of service, accomplished without overloading either site storage, catalogues or other DQ2 components. Also specialty of database backend implementation will be described. Special section will be devote to the deletion monitoring service that allows operators a detailed view of the working system.

  17. ATLAS Award for Difficult Task

    CERN Multimedia

    2004-01-01

    Two Russian companies were honoured with an ATLAS Award, for supply of the ATLAS Inner Detector barrel support structure elements, last week. On 23 March the Russian company ORPE Technologiya and its subcontractor, RSP Khrunitchev, were jointly presented with an ATLAS Supplier Award. Since 1998, ORPE Technologiya has been actively involved in the development of the carbon-fibre reinforced plastic elements of the ATLAS Inner Detector barrel support structure. After three years of joint research and development, CERN and ORPE Technologiya launched the manufacturing contract. It had a tight delivery schedule and very demanding specifications in terms of mechanical tolerance and stability. The contract was successfully completed with the arrival of the last element of the structure at CERN on 8 January 2004. The delivery of this key component of the Inner Detector deserves an ATLAS Award given the difficulty of manufacturing the end-frames, which very few companies in the world would have been able to do at an ...

  18. Using FTK tracks for particle flow reconstruction at the high-level trigger of ATLAS

    CERN Document Server

    Jaeger, Benjamin Paul

    2016-01-01

    The Fast Tracker (FTK) enables the ATLAS high-level trigger (HLT) to have early access to global tracking information. The project of my Summer Student Internship at CERN was to investigate the potential of using particle flow reconstruction with FTK tracks at the ATLAS HLT. This report shortly summarizes my studies, ranging from comparison of FTK tracks with offline tracks to more sophisticated analyses, such as assessing the jet resolution and trigger related properties.

  19. The ATLAS Forward Calorimeter

    Science.gov (United States)

    Artamonov, A.; Bailey, D.; Belanger, G.; Cadabeschi, M.; Chen, T.-Y.; Epshteyn, V.; Gorbounov, P.; Joo, K. K.; Khakzad, M.; Khovanskiy, V.; Krieger, P.; Loch, P.; Mayer, J.; Neuheimer, E.; Oakham, F. G.; O'Neill, M.; Orr, R. S.; Qi, M.; Rutherfoord, J.; Savine, A.; Schram, M.; Shatalov, P.; Shaver, L.; Shupe, M.; Stairs, G.; Strickland, V.; Tompkins, D.; Tsukerman, I.; Vincent, K.

    2008-02-01

    Forward calorimeters, located near the incident beams, complete the nearly 4π coverage for high pT particles resulting from proton-proton collisions in the ATLAS detector at the Large Hadron Collider at CERN. Both the technology and the deployment of the forward calorimeters in ATLAS are novel. The liquid argon rod/tube electrode structure for the forward calorimeters was invented specifically for applications in high rate environments. The placement of the forward calorimeters adjacent to the other calorimeters relatively close to the interaction point provides several advantages including nearly seamless calorimetry and natural shielding for the muon system. The forward calorimeter performance requirements are driven by events with missing ET and tagging jets.

  20. The ATLAS ROBIN

    Energy Technology Data Exchange (ETDEWEB)

    Cranfield, R; Crone, G [University College London, London (United Kingdom); Francis, D; Gorini, B; Joos, M; Petersen, J; Tremblet, L; Unel, G [CERN, Geneva (Switzerland); Green, B; Misiejuk, A; Strong, J; Teixeira-Dias, P [Royal Holloway University of London, London (United Kingdom); Kieft, G; Vermeulen, J [FOM - Institute SAF and University of Amsterdam/Nikhef, Amsterdam (Netherlands); Kugel, A; Mueller, M; Yu, M [University of Mannheim, Mannheim (Germany); Perera, V; Wickens, F [Rutherford Appleton Laboratory, Didcot (United Kingdom)], E-mail: kugel@ti.uni-mannheim.de

    2008-01-15

    The ATLAS readout subsystem is the main interface between {approx} 1600 detector front-end readout links and the higher-level trigger farms. To handle the high event rate (up to 100 kHz) and bandwidth (up to 160 MB/s per link) the readout PCs are equipped with four ROBIN (readout buffer input) cards. Each ROBIN attaches to three optical links, provides local event buffering for approximately 300 ms and communicates with the higher-level trigger system for data and delete requests. According to the ATLAS baseline architecture this communication runs via the PCI bus of the host PC. In addition, each ROBIN provides a private Gigabit Ethernet port which can be used for the same purpose. Operational monitoring is performed via PCI. This paper presents a summary of the ROBIN hardware and software together with measurements results obtained from various test setups.

  1. Electroweak Physics at ATLAS

    CERN Document Server

    Conti, G; The ATLAS collaboration

    2013-01-01

    Various electroweak measurements have already been performed at the ATLAS experiment since the start of the Large Hadron Collider at CERN. A review of the latest results in $W/Z$ and diboson physics will be given here. The $W/Z$ physics results include the measurement of the high-mass Drell-Yan di-lepton production cross section, the $Wb(b)$ production cross section and the study of the transverse momentum of $Z/\\gamma^*$. The latest $WW$, $WZ$, $ZZ$, $W\\gamma$ and $Z\\gamma$ production cross sections will be summarized, including updated $WW$ and $ZZ$ results. In particular, the $ZZ^*$ channel has been added. The ATLAS diboson results are also used to set limits on charged triple gauge couplings ($WWZ$, $WW\\gamma$) and on neutral triple gauge couplings ($Z\\gamma\\gamma$, $ZZ\\gamma$, $ZZZ$).

  2. ATLAS software packaging

    CERN Document Server

    Rybkin, G

    2012-01-01

    Software packaging is indispensable part of build and prerequisite for deployment processes. Full ATLAS software stack consists of TDAQ, HLT, and Offline software. These software groups depend on some 80 external software packages. We present tools, package PackDist, developed and used to package all this software except for TDAQ project. PackDist is based on and driven by CMT, ATLAS software configuration and build tool, and consists of shell and Python scripts. The packaging unit used is CMT project. Each CMT project is packaged as several packages - platform dependent (one per platform available), source code excluding header files, other platform independent files, documentation, and debug information packages (the last two being built optionally). Packaging can be done recursively to package all the dependencies. The whole set of packages for one software release, distribution kit, also includes configuration packages and contains some 120 packages for one platform. Also packaged are physics analysis pro...

  3. Networks in ATLAS

    CERN Document Server

    Mc Kee, Shawn Patrick; The ATLAS collaboration

    2016-01-01

    Networks have played a critical role in high-energy physics (HEP), enabling us to access and effectively utilize globally distributed resources to meet the needs of our physicists. Because of their importance in enabling our grid computing infrastructure many physicists have taken leading roles in research and education (R&E) networking, participating in, and even convening, network related meetings and research programs with the broader networking community worldwide. This has led to HEP benefiting from excellent global networking capabilities for little to no direct cost. However, as other science domains ramp-up their need for similar networking it becomes less clear that this situation will continue unchanged. What this means for ATLAS in particular needs to be understood. ATLAS has evolved its computing model since the LHC started based upon its experience with using globally distributed resources. The most significant theme of those changes has been increased reliance upon, and use of, its networks....

  4. Electron isolation at ATLAS

    International Nuclear Information System (INIS)

    The ATLAS experiment at the Large Hadron Collider (LHC) will face the challenge of efficiently selecting interesting candidate events in pp collisions at 14 TeV centre-of-mass energy, whilst rejecting the enormous number of background events. Many of these interesting candidate events have isolated leptons in the final state, like for example events with a gauge boson or SUSY. On top of the standard ATLAS electron identification an isolation criterion has been developed using a likelihood as multivariate approach with several discriminating variables. The likelihood is constructed by selecting electrons from Z decays for the signal and for the background electrons from b quark jets. Results for the example of the associated Higgs boson production with top quarks and subsequent decay into a pair of W bosons are presented. In addition first results of a likelihood to discriminate against jets are given and a possible extension for muons is discussed

  5. Jet substructure in ATLAS

    CERN Document Server

    Miller, David W

    2011-01-01

    Measurements are presented of the jet invariant mass and substructure in proton-proton collisions at $\\sqrt{s} = 7$ TeV with the ATLAS detector using an integrated luminosity of 37 pb$^{-1}$. These results exercise the tools for distinguishing the signatures of new boosted massive particles in the hadronic final state. Two "fat" jet algorithms are used, along with the filtering jet grooming technique that was pioneered in ATLAS. New jet substructure observables are compared for the first time to data at the LHC. Finally, a sample of candidate boosted top quark events collected in the 2010 data is analyzed in detail for the jet substructure properties of hadronic "top-jets" in the final state. These measurements demonstrate not only our excellent understanding of QCD in a new energy regime but open the path to using complex jet substructure observables in the search for new physics.

  6. Major Achievements and Prospect of the ATLAS Integral Effect Tests

    Directory of Open Access Journals (Sweden)

    Ki-Yong Choi

    2012-01-01

    Full Text Available A large-scale thermal-hydraulic integral effect test facility, ATLAS (Advanced Thermal-hydraulic Test Loop for Accident Simulation, has been operated by KAERI. The reference plant of ATLAS is the APR1400 (Advanced Power Reactor, 1400 MWe. Since 2007, an extensive series of experimental works were successfully carried out, including large break loss of coolant accident tests, small break loss of coolant accident tests at various break locations, steam generator tube rupture tests, feed line break tests, and steam line break tests. These tests contributed toward an understanding of the unique thermal-hydraulic behavior, resolving the safety-related concerns and providing validation data for evaluation of the safety analysis codes and methodology for the advanced pressurized water reactor, APR1400. Major discoveries and lessons found in the past integral effect tests are summarized in this paper. As the demand for integral effect tests is on the rise due to the active national nuclear R&D program in Korea, the future prospects of the application of the ATLAS facility are also discussed.

  7. 10 CFR 2.1018 - Discovery.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Discovery. 2.1018 Section 2.1018 Energy NUCLEAR REGULATORY... legal theories of an attorney or other representative of a party, potential party, or interested... section does not apply to requests for the testimony of the NRC regulatory staff under § 2.709. (g)...

  8. SUSY Searches in ATLAS

    CERN Document Server

    Zhuang, Xuai; The ATLAS collaboration

    2016-01-01

    Despite the absence of experimental evidence, weak scale supersymmetry remains one of the best motivated and studied Standard Model extensions. This talk summarises recent ATLAS results for searches for supersymmetric (SUSY) particles, with focus on those obtained using proton-proton collisions at a centre of mass energy of 13 TeV using 2015+2016 data. The searches with final states including jets, missing transverse momentum, light leptons will be presented.

  9. ATLAS support rails

    CERN Multimedia

    Maximilien Brice

    2003-01-01

    These supports will hold the 7000 tonne ATLAS detector in its cavern at the LHC. The huge toroid will be assembled from eight coils that will house some of the muon chambers. Supported within the toroid will be the inner detector, containing tracking devices, as well as devices to measure the energies of the particles produced in the 14 TeV proton-proton collisions at the LHC.

  10. Topographical atlas sheets

    Science.gov (United States)

    Wheeler, George Montague

    1876-01-01

    The following topographical atlas sheets, accompanying Appendix J.J. of the Annual Report of the Chief of Engineers, U.S. Army-being Annual Report upon U. S. Geographical Surveys-have been published during the fiscal year ending June 30, 1876, and are a portion of the series projected to embrace the territory of the United States lying west of the 100th meridian.

  11. Overview of ATLAS results

    CERN Document Server

    Grabowska-Bold, Iwona; The ATLAS collaboration

    2016-01-01

    The ATLAS experiment at the Large Hadron Collider has undertaken a broad physics program to probe and characterize the hot nuclear matter created in relativistic lead-lead collisions. This talk presents recent results based on Run 2 data on production of jet, electroweak bosons and quarkonium, electromagnetic processes in ultra-peripheral collisions, and bulk particle collectivity from PbPb, pPb and pp collisions.

  12. ATLAS/CMS Upgrades

    CERN Document Server

    Horii, Yasuyuki; The ATLAS collaboration

    2016-01-01

    Precise Higgs measurements and new physics searches are planned at LHC (HL-LHC) with integrated luminosity of 300 fb^{-1} (3000 fb^{-1}). An increased peak luminosity provides a significant challenge for the experiments. In this presentation, the plans for the ATLAS and CMS upgrades are introduced. Physics prospects for some topics related with ‘flavour’, e.g Higgs couplings, B_{s, d}->mumu, and FCNC top decays, are also shown.

  13. Hybrid Atlas Models

    CERN Document Server

    Ichiba, Tomoyuki; Banner, Adrian; Karatzas, Ioannis; Fernholz, Robert

    2009-01-01

    We study Atlas-type models of equity markets with local characteristics that depend on both name and rank, and in ways that induce a stability of the capital distribution. Ergodic properties and rankings of processes are examined with reference to the theory of reflected Brownian motions in polyhedral domains. In the context of such models, we discuss properties of various investment strategies, including the so-called growth-optimal and universal portfolios.

  14. L'esperimento ATLAS

    CERN Multimedia

    ATLAS Outreach Committee

    2000-01-01

    This award winning film gives a glimpse behind the scenes of building the ATLAS detector. This film asks: Why are so many physicists anxious to build this apparatus? Will they be able to answer fundamental questions such as: Where does mass come from? Why does the Universe have so little antimatter? Are there extra dimensions of space that are hidden from our view? Is there an underlying theory to find? Major surprises are likely in this unknown part of physics.

  15. El experimento ATLAS

    CERN Multimedia

    ATLAS Outreach Committee

    2000-01-01

    This award winning film gives a glimpse behind the scenes of building the ATLAS detector. This film asks: Why are so many physicists anxious to build this apparatus? Will they be able to answer fundamental questions such as: Where does mass come from? Why does the Universe have so little antimatter? Are there extra dimensions of space that are hidden from our view? Is there an underlying theory to find? Major surprises are likely in this unknown part of physics.

  16. The ATLAS Experiment Movie

    CERN Multimedia

    ATLAS Outreach Committee

    2000-01-01

    This award winning film gives a glimpse behind the scenes of building the ATLAS detector. This film asks: Why are so many physicists anxious to build this apparatus? Will they be able to answer fundamental questions such as: Where does mass come from? Why does the Universe have so little antimatter? Are there extra dimensions of space that are hidden from our view? Is there an underlying theory to find? Major surprises are likely in this unknown part of physics.

  17. The Genome Atlas Resource

    OpenAIRE

    Azam Qureshi, Matloob; Rotenberg, Eva; Stærfeldt, Hans Henrik; Hansson, Lena; Ussery, David

    2010-01-01

    Abstract. The Genome Atlas is a resource for addressing the challenges of synchronising prokaryotic genomic sequence data from multiple public repositories. This resource can integrate bioinformatic analyses in various data format and quality. Existing open source tools have been used together with scripts and algorithms developed in a variety of programming languages at the Centre for Biological Sequence Analysis in order to create a three-tier software application for genome analysis. The r...

  18. Constraints on new phenomena through Higgs coupling measurements with the ATLAS detector

    CERN Document Server

    Carrillo Montoya, German David; The ATLAS collaboration

    2015-01-01

    The discovery of the Higgs boson opens many perspectives to explore physics beyond the Standard Model. This talk describes constraints of new physics in a number of models using the combined measurements of the coupling strength of the 125 GeV Higgs particle using the entire ATLAS run-I data. The various models presented include an additional real electroweak singlet, two Higgs doublet models, a simplified Minimal Supersymmetric Standard Model, and a Higgs portal to dark matter.

  19. College Discovery and Development Program; School Year, 1975-76.

    Science.gov (United States)

    Bergenn, Victor W.

    The primary objective of the College Discovery and Development Program (CDD), funded under the Elementary Secondary Education Act Title I, has been the discovery and development of the college potential of high school youth who are academically and financially disadvantaged. This program was designed to improve the reading and mathematics…

  20. Evaluating ten discoveries

    Energy Technology Data Exchange (ETDEWEB)

    1973-02-01

    Mexico's state company, Pemex, announces 10 significant oil and gas discoveries in the states of Tamaulipas and Chiapas. Most promising finds are a new oil province in S. Mexico and a deeper pool strike at the offshore Arenque field. The latter seems to point to the existence of an attractive reefal trend extending on shore toward the State of Nuevo Leon.