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Sample records for atherosclerosis san antonio

  1. San Antonio Bay 1986-1989

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The effect of salinity on utilization of shallow-water nursery habitats by aquatic fauna was assessed in San Antonio Bay, Texas. Overall, 272 samples were collected...

  2. Biological and associated water-quality data for lower Olmos Creek and upper San Antonio River, San Antonio, Texas, March-October 1990

    Science.gov (United States)

    Taylor, R. Lynn

    1995-01-01

    Biological and associated water-quality data were collected from lower Olmos Creek and upper San Antonio River in San Antonio, Texas, during March-October 1990, the second year of a multiyear data-collection program. The data will be used to document water-quality conditions prior to implementation of a proposal to reuse treated wastewater to irrigate city properties in Olmos Basin and Brackenridge Parks and to augment flows in the Olmos Creek/San Antonio River system.

  3. 77 FR 36041 - San Antonio Central Railroad, L.L.C.-Lease Exemption-Port Authority of San Antonio

    Science.gov (United States)

    2012-06-15

    ... control of SAC upon SAC becoming a Class III rail carrier. As a result of this transaction, SAC will provide common carrier rail service over the rail lines owned by the Port in the East Kelly Railport (the... and operate approximately four miles of rail line owned by the Port Authority of San Antonio (the Port...

  4. City of San Antonio, Texas Better Buildings Program

    Energy Technology Data Exchange (ETDEWEB)

    Meyer, Liza C. [City of San Antonio, TX (United States); Hammer, Mary C. [City of San Antonio, TX (United States)

    2014-06-30

    The San Antonio Better Buildings Program is a unified single-point-of-service energy efficiency delivery mechanism targeting residential, commercial, institutional, industrial and public buildings. This comprehensive and replicable energy efficiency program is designed to be an effective demand side management initiative to provide a seamless process for program participants to have turn-key access to expert analysis, support and incentives to improve the performance of their in-place energy using systems, while reducing electrical energy use and demand.

  5. Feasibility study on rehabilitation of ICE San Antonio Power Plant

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-03-01

    Costa Rica takes a power generation system using hydro power generation as the main source, and possesses medium-capacity gas turbines to supplement needs in the dry season and the peak load. However, a problem has come up that, in addition to the cost rise in gas turbine fuel, the power generation efficiency has been aggravating due to aged deterioration of the generators being used. In association therewith, the problem is now a factor to increase CO2 emission, which is a worldwide problem. Keeping in mind to link it to the clean development mechanism (CDM), the present project is, taking up the SAN ANTONIO power plant as the investigation object, intended to perform a comprehensive discussion on the CO2 emission reducing effect, profitability, and proliferation effect, by executing the conceptual plant design. The up-grading plan for thermal power generation systems in Costa Rica consists of replacement of the gas turbines, handling of phase modifiers, and achievement of the combined cycle. The plan agrees with the present feasibility study intended of CO2 emission reduction, consisting of the modification plan of the SAN ANTONIO power plant, that is the plan to replace the over-aged gas turbines at the power plant. Its necessity has been identified. It was disclosed that the project has the effects of reducing CO2 of 82,000 tons annually, and the investment can be recovered in nine years. (NEDO)

  6. United States Air Force Personalized Medicine and Advanced Diagnostics Program Panel: Representative Research at the San Antonio Military Medical Center

    Science.gov (United States)

    2016-05-20

    health system. dedicated to excellence in global care PROCESSING OF PROFESSIONAL MEDICAL RESEARCH PUBLICATIONS/PRESENTATIONS INSTRUCTIONS 1. The...present this research at the University of Texas at San Antonio/SAMHS & Universities Research Forum, SURF 2016 in San Antonio, TX, on 20 May 2016. The...at San Antonio/SAMHS & Universities Research Forum, SURF 2016 in San Antonio, TX, on 20 May 2016. 3. LAWS AND REGULATIONS: DoD 5500.07-R, Joint

  7. Implementation of an Online Climate Science Course at San Antonio College

    Science.gov (United States)

    Reyes, R.; Strybos, J.

    2016-12-01

    San Antonio College (SAC) plans to incorporate an online climate science class into the curriculum with a focus on local weather conditions and data. SAC is part of a network of five community colleges based around San Antonio, Texas, has over 20,000 students enrolled, and its student population reflects the diversity in ethnicity, age and gender of the San Antonio community. The college understands the importance of educating San Antonio residents on climate science and its complexities. San Antonio residents are familiar with weather changes and extreme conditions. The region has experienced an extreme drought, including water rationing in the city. Then, this year's El Niño intensified expected annual rainfalls and flash floods. The proposed climate science course will uniquely prepare students to understand weather data and the evidence of climate change impacting San Antonio at a local level. This paper will discuss the importance and challenges of introducing the new climate science course into the curriculum, and the desired class format that will increase the course's success. Two of the most significant challenges are informing students about the value of this class and identifying the best teaching format. Additionally, measuring and monitoring enrollment will be essential to determine the course performance and success. At the same time, Alamo Colleges is modifying the process of teaching online classes and is officially working to establish an online college. Around 23% of students enrolled in SAC offered courses are currently enrolled in online courses only, representing an opportunity to incorporate the climate science class as an online course. Since the proposed course will be using electronic textbooks and online applications to access hyperlocal weather data, the class is uniquely suited for online students.

  8. An Assessment of the Effectiveness of Remedial Reading Courses at San Antonio College.

    Science.gov (United States)

    Florio, Charles Bernard

    This study investigates the effectiveness of remedial reading courses for nontraditional students in San Antonio College, a large, urban, and public community college in Texas. The subjects were students who enrolled the fall semester of 1972 and persisted through the fall semester of 1973. The remedial reading courses were described in terms of…

  9. Bridging the Scholar-Practitioner Gap: The San Antonio Export Leaders Program

    Science.gov (United States)

    Jackson, Sara C.

    2013-01-01

    Bridging the gap between theory and practice enables trade service providers to effectively reach the small business community interested in entering foreign markets. This paper describes how the award-winning San Antonio Export Leaders program is a model for applying theoretical concepts to the practice of international business.

  10. 77 FR 38078 - U.S. Nominations to the World Heritage List: San Antonio Franciscan Missions

    Science.gov (United States)

    2012-06-26

    ... ownership rights in U.S. World Heritage Sites, which continue to be subject only to U.S. law. Inclusion in... group should be considered as an extension to the Mexican missions of the Sierra Gorda already on the... experts in the topic in San Antonio, including Mexican World Heritage officials, concluded that the...

  11. 77 FR 35376 - San Antonio Water System; Notice of Petition for Declaratory Order and Soliciting Comments...

    Science.gov (United States)

    2012-06-13

    ... in large diameter water pipelines. The water flow in the CRP pipeline at Naco is reduced from a 36... Water System; Notice of Petition for Declaratory Order and Soliciting Comments, Protests, and/or Motions...-000. c. Date Filed: May 29, 2012. d. Applicant: San Antonio Water System (SAWS). e. Name of Project...

  12. Biological and associated water-quality data for lower Olmos Creek and upper San Antonio River, San Antonio, Texas, April - September 1989

    Science.gov (United States)

    Taylor, R. Lynn; Ferreira, Rodger F.

    1995-01-01

    Biological and associated water-quality data were collected from lower Olmos Creek and upper San Antonio River in San Antonio, Texas, during April-September 1989. Benthic macroinvertebrate, periphyton, and phytoplankton communities were sampled at three sites along the Olmos Creek/San Antonio River system. Total mean densities of benthic macroinvertebrates for the three sites ranged from 670 to 10,000 organisms per square meter. The most abundant macroinvertebrates were the class Insecta (insects). Total densities of periphyton ranged from 2,900 to 110,000 cells per square millimeter. Cyanophyta (blue-green algae) and Bacillariophyta (diatoms) were the predominant periphyton organisms. Total densities of phyto- plankton ranged from 5,000 to 47,000 cells per square milliliter. Blue-green algae accounted for more than one- half of the phytoplankton in each sample. Hardness ranged from 160 to 250 milligrams per liter as calcium carbonate, and alkalinity ranged from 130 to 220 milligrams per liter as calcium carbonate. The largest dissolved nitrite concentration was 0.038 milligram per liter. The largest total phosphorus concentration was 0.150 milligram per liter, over one-half of which was dissolved orthophosphate. Total aluminum and total iron were the only trace elements in water to exceed the reporting threshold by large concen- trations. Total aluminum concentrations ranged from 70 to 280 micrograms per liter, and total iron concentrations ranged from 70 to 340 micrograms per liter. Lead was the most prominent trace element in bottom-material samples, with concentrations ranging from 30 to 230 micrograms per gram.

  13. Financial Reporting for the Other Defense Organizations - General Funds at the Defence Finance and Accounting Service San Antonio

    National Research Council Canada - National Science Library

    2002-01-01

    ...) for inclusion in the FY 2001 Other Defense Organizations Financial Statements. Specifically, we looked at the abnormal balances reported in trial balances prepared by the Defense Finance and Accounting Service San Antonio...

  14. LaRC Modeling of Ozone Formation in San Antonio, Texas

    Science.gov (United States)

    Guo, F.; Griffin, R. J.; Bui, A.; Schulze, B.; Wallace, H. W., IV; Flynn, J. H., III; Erickson, M.; Kotsakis, A.; Alvarez, S. L.; Usenko, S.; Sheesley, R. J.; Yoon, S.

    2017-12-01

    Ozone (O3) is one of the most important trace species within the troposphere and results from photochemistry involving emissions from a complex array of sources. Ground-level O3 is detrimental to ecosystems and causes a variety of human health problems including respiratory irritation, asthma and reduction in lung capacity. However, the O3 Design Value in San Antonio, Texas, was in violation of the federal threshold set by the EPA (70 ppb, 8-hr max) based on the average for the most recent three-year period (2014-2016). To understand the sources of high O3 concentrations in this nonattainment area, we assembled and deployed a mobile air quality laboratory and operated it in two locations in the southeast (Traveler's World RV Park) and northwest (University of Texas at San Antonio) of downtown San Antonio during summer 2017 to measure O3 and its precursors, including total nitrogen oxides (NOx) and volatile organic compounds (VOCs). Additional measurements included temperature, relative humidity, pressure, solar radiation, wind speed, wind direction, total reactive nitrogen (NOy), carbon monoxide (CO), and aerosol composition and concentration. We will use the campaign data and the NASA Langley Research Center (LaRC) Zero-Dimensional Box Model (Crawford et al., 1999; Olson et al., 2006) to calculate O3 production rate, NOx and hydroxyl radical chain length, and NOx versus VOCs sensitivity at different times of a day with different photochemical and meteorological conditions. A key to our understanding is to combine model results with measurements of precursor gases, particle chemistry and particle size to support the identification of O3 sources, its major formation pathways, and how the ozone production efficiency (OPE) depends on various factors. The resulting understanding of the causes of high O3 concentrations in the San Antonio area will provide insight into future air quality protection.

  15. Water quality modelling in the San Antonio River Basin driven by radar rainfall data

    Directory of Open Access Journals (Sweden)

    Almoutaz Elhassan

    2016-05-01

    Full Text Available Continuous monitoring of stream water quality is needed as it has significant impacts on human and ecological health and well-being. Estimating water quality between sampling dates requires model simulation based on the available geospatial and water quality data for a given watershed. Models such as the Soil and Water Assessment Tool (SWAT can be used to estimate the missing water quality data. In this study, SWAT was used to estimate water quality at a monitoring station near the outlet of the San Antonio River. Precipitation data from both rain gauges and weather radar were used to force the SWAT simulations. Virtual rain gauges which were based on weather radar data were created in the approximate centres of the 163 sub-watersheds of the San Antonio River Basin for SWAT simulations. This method was first tested in a smaller watershed in the middle of the Guadalupe River Basin resulting in increased model efficiency in simulating surface run-off. The method was then applied to the San Antonio River watershed and yielded good simulations for surface run-off (R2 = 0.7, nitrate (R2 = 0.6 and phosphate (R2 = 0.5 at the watershed outlet (Goliad, TX – USGS (United States Geological Survey gauge as compared to observed data. The study showed that the proper use of weather radar precipitation in SWAT model simulations improves the estimation of missing water quality data.

  16. Late Quaternary evolution of the San Antonio Submarine Canyon in the central Chile forearc (∼33°S)

    Science.gov (United States)

    Laursen, Jane; Normark, William R.

    2002-01-01

    Hydrosweep swath-bathymetry and seismic-reflection data reveal the morphology, sedimentary processes, and structural controls on the submarine San Antonio Canyon. The canyon crosses the forearc slope of the central Chile margin for more than 150 km before it empties into the Chile Trench near 33°S latitude. In its upper reaches, the nearly orthogonal segments of the San Antonio Canyon incise ∼1 km into thick sediment following underlying margin-perpendicular basement faults and along the landward side of a prominent margin-parallel thrust ridge on the outer mid-slope. At a breach in the outer ridge, the canyon makes a sharp turn into the San Antonio Reentrant. Resistance to erosion of outcropping basement at the head of the reentrant has prevented the development of a uniformly sloping thalweg, leaving gentle gradients (6°) across the lower slope. Emergence of an obstruction across the head of the San Antonio Reentrant has trapped sediment in the mid-slope segments of the canyon. Presently, little sediment appears to reach the Chile Trench through the San Antonio Canyon. The development of the San Antonio Canyon was controlled by the impact of a subducted seamount, which formed the San Antonio Reentrant and warped the middle slope along its landward advancing path. Incision of the canyon landward of the outer mid-slope ridge may be ascribed to a combination of headward erosion and entrenchment by captured unconfined turbidity currents. Flushing of the canyon was likely enhanced during the lowered sea level of the last glaciation. Where the canyon occupies the triangular embayment of the reentrant at the base of the slope, sediment has ponded behind a small accretionary ridge. On the trench floor opposite the San Antonio Canyon mouth, a 200-m-thick levee–overbank complex formed on the left side of a distributary channel emanating from a breach in the accretionary ridge. Axial transfer of sediment was inhibited to the north of the San Antonio Canyon mouth

  17. Food, feeding, and refuelling of Red Knots during northward migration at San Antonio Oeste, Rio Negro, Argentina

    NARCIS (Netherlands)

    Gonzalez, PM; Piersma, T; Verkuil, Y; González, Patricia M.

    1996-01-01

    We studied the food and feeding ecology of Red Knots Calidris canutus rufa on an area of rocky flat, or restinga, near San Antonio Oeste in the northwest of Golfo San Matias, Provincia de Rio Negro, Argentina in March 1992. These Red Knots are on their way north, from ''wintering'' areas in Tierra

  18. The new library building at the University of Texas Health Science Center at San Antonio.

    Science.gov (United States)

    Kronick, D A; Bowden, V M; Olivier, E R

    1985-04-01

    The new University of Texas Health Science Center at San Antonio Library opened in June 1983, replacing the 1968 library building. Planning a new library building provides an opportunity for the staff to rethink their philosophy of service. Of paramount concern and importance is the need to convey this philosophy to the architects. This paper describes the planning process and the building's external features, interior layouts, and accommodations for technology. Details of the move to the building are considered and various aspects of the building are reviewed.

  19. Rodriquez V. San Antonio Independent School District: Gathering the Ayes of Texas--The Politics of School Finance Reform

    Science.gov (United States)

    Yudof, Mark G.; Morgan, Daniel C.

    1974-01-01

    An historical account is given of movements toward educational finance reform in Texas, culminating in the Rodriquez v. San Antonio Independent School District case and its aftermath. The role of political pressures applied by various interest groups is traced and the prospects for future reform assessed. (EH)

  20. Modernizing "San Antonio Independent School District v. Rodriguez": How Evolving Supreme Court Jurisprudence Changes the Face of Education Finance Litigation

    Science.gov (United States)

    Saleh, Matthew

    2011-01-01

    This article aims to "modernize" the current legal debate over inequitable public school funding at the state and local level. The 1973 Supreme Court case of "San Antonio Independent School District v. Rodriguez" established precedent, allowing for property-tax based education funding programs at the state-level--a major source…

  1. Discharge between San Antonio Bay and Aransas Bay, southern Gulf Coast, Texas, May-September 1999

    Science.gov (United States)

    East, Jeffery W.

    2001-01-01

    Along the Gulf Coast of Texas, many estuaries and bays are important habitat and nurseries for aquatic life. San Antonio Bay and Aransas Bay, located about 50 and 30 miles northeast, respectively, of Corpus Christi, are two important estuarine nurseries on the southern Gulf Coast of Texas (fig. 1). According to the Texas Parks and Wildlife Department, “Almost 80 percent of the seagrasses [along the Texas Gulf Coast] are located in the Laguna Madre, an estuary that begins just south of Corpus Christi Bay and runs southward 140 miles to South Padre Island. Most of the remaining seagrasses, about 45,000 acres, are located in the heavily traveled San Antonio, Aransas and Corpus Christi Bay areas” (Shook, 2000).Population growth has led to greater demands on water supplies in Texas. The Texas Water Development Board, the Texas Parks and Wildlife Department, and the Texas Natural Resource Conservation Commission have the cooperative task of determining inflows required to maintain the ecological health of the State’s streams, rivers, bays, and estuaries. To determine these inflow requirements, the three agencies collect data and conduct studies on the need for instream flows and freshwater/ saline water inflows to Texas estuaries.To assist in the determination of freshwater inflow requirements, the U.S. Geological Survey (USGS), in cooperation with the Texas Water Development Board, conducted a hydrographic survey of discharge (flow) between San Antonio Bay and Aransas Bay during the period May–September 1999. Automated instrumentation and acoustic technology were used to maximize the amount and quality of data that were collected, while minimizing personnel requirements. This report documents the discharge measured at two sites between the bays during May–September 1999 and describes the influences of meteorologic (wind and tidal) and hydrologic (freshwater inflow) conditions on discharge between the two bays. The movement of water between the bays is

  2. Geochemistry of the thermal springs from San Antonio El Bravo zone, Chihuahua, Mexico; Geoquimica de manantiales termales de la zona de San Antonio El Bravo, Chihuahua, Mexico

    Energy Technology Data Exchange (ETDEWEB)

    Tello Hinojosa, Enrique [Gerencia de Proyectos Geotermoelectricos de la Comision Federal de Electricidad, Morelia (Mexico)

    1996-05-01

    Isotopic and chemical analysis o water produced by 14 springs in the San Antonio El Bravo, Chihuahua, Mexico geothermal area, were carried out in order to establish the geochemical characteristics of the groundwater and to know their interaction with deeper geothermal fluids. We made two samplings of water and gases in 1984 and 1995. The chemical composition of waters produced by the springs in of sodium-bicarbonate-chloride type. It was found, according to the Na:K:Mg relative content, that most hot springs are located in the partial equilibrium zone, whereas the lowest temperature hot springs shift toward the groundwaters domain. The temperature estimated from gas geothermometry was 129 degrees celsius. The isotopic composition at Ojo Caliente and Infiernito springs presents enrichment in {delta}{sup 18}O, product rock-water interaction at high temperature. The Agua Roque spring is located in the line of meteoric waters. Analysis of metals was carried out too, the concentration of gold element is 0.09 mg/l in Ojo Caliente and Infiernito springs, whereas silver, aluminum and iron elements were not detected. The water quality of the springs for agricultural use, is classified between C2-S1, C3-S1, C3- S2, C4-S3 and C4-S4 types, that suggests that only the water from Agua Roque can be used for irrigation. The arsenic element was not detected but the concentration of the boron element is high for irrigation use (2.39 ppm). [Espanol] Los analisis quimicos e isotopicos de agua de 14 manantiales de la zona de San Antonio El Bravo. Chihuahua, Mexico, fueron realizados con el fin de conocer las caracteristicas geoquimicas del acuifero somero y su interaccion con fluidos geotermicos. Se realizaron 2 muestreos tanto de agua como de gases en 1984 y 1995. En ambos muestreos se encontro que la composicion quimica del agua de todos los manantiales es del tipo bicarbonatado-clorurado-sodico. De acuerdo con el contenido relativo de Na:K:Mg el agua de los manantiales mas calientes

  3. Automated vehicle identification tags in San Antonio : lessons learned from the metropolitan model deployment initiative : unique method for collecting arterial travel speed information

    Science.gov (United States)

    2000-10-01

    This report demonstrates a unique solution to the challenge of providing accurate, timely estimates of arterial travel times to the motoring public. In particular, it discusses the lessons learned in deploying the Vehicle Tag Project in San Antonio, ...

  4. Appraisal of ground-water resources in the San Antonio Creek Valley, Santa Barbara County, California

    Science.gov (United States)

    Hutchinson, C.B.

    1980-01-01

    A nearly threefold increase in demand for water in the 154-square-mile San Antonio Creek valley in California during the period 1958-77 has increased the potential for overdraft on the ground-water basin. The hydrologic budget for this period showed a perennial yield of about 9,800 acre-feet per year and an annual ground-water discharge of about 11,400 acre-feet per year, comprising net pumpage of 7,100 acre-feet, phreatophyte evapotranspiration of 3,000 acre-feet, and base streamflow of 1 ,300 acre-feet. The base flow in San Antonio Creek could diminish to zero when net pumpage reaches 13,500 acre-feet per year. The environmentally sensitive marshland area of Barka Slough may then become stressed as water normally lost through evapotranspiration is captured by pumpage. The aquifer consists of alluvial valley fill that ranges in thickness from 0 to 3,500 feet. Ground water moves seaward from recharge areas along mountain fronts to a consolidated rock barrier about 5 miles east of the Pacific coast. Upwelling of ground water just east of the barrier has resulted in the 550-acre Barka Slough. Transmissivity of the aquifer ranges from 2,600 to 34,000 feet squared per day, with the lowest values occurring in the central part of the valley where the aquifer is thickest but probably finer grained. The salinity problems are increasing in the agricultural parts of the valley, which is east of the barrier. West of the barrier, stream and ground-water quality is poor, owing to seepage of saline water from the marine shale that underlies the area at shallow depths. A proposed basinwide monitoring program includes 17 water-level sites, 12 water-quality sampling sites, 3 streamflow measuring sites, and periodic infrared aerial photography of Barka Slough. A computer model of the ground-water flow system could be developed to assess the impact of various water-management alternatives. (USGS)

  5. Local adaptation of the National Physical Activity Plan: creation of the Active Living Plan for a Healthier San Antonio.

    Science.gov (United States)

    Esparza, Laura A; Velasquez, Katherine S; Zaharoff, Annette M

    2014-03-01

    Physical inactivity and related health consequences are serious public health threats. Effective strategies to facilitate and support active-living opportunities must be implemented at national, state, and local levels. San Antonio, Texas, health department officials launched the Active Living Council of San Antonio (ALCSA) to engage the community in developing a 3- to 5-year plan to promote active living. A steering committee set preliminary ALCSA aims and established a multisector membership structure modeled after the US National Physical Activity Plan (NPAP). ALCSA adopted governance standards, increased knowledge of physical activity and health, and engaged in an 18-month collaborative master plan writing process. ALCSA selected overarching strategies and evidence-based strategies for each societal sector and adapted strategies to the local context, including tactics, measures of success, and timelines. Community and expert engagement led to a localized plan reflecting national recommendations, the Active Living Plan for a Healthier San Antonio. Multisector collaborations among governmental agencies and community organizations, which were successfully developed in this case to produce the first-ever local adaptation of the NPAP, require clearly defined expectations. Lessons learned in ALCSA's organizational and plan development can serve as a model for future community-driven efforts to increase active living.

  6. Building America Case Study: Occupant Comfort from a Mini-Split Heat Pump, San Antonio, Texas

    Energy Technology Data Exchange (ETDEWEB)

    2017-03-03

    IBACOS worked with builder Imagine Homes to evaluate the performance of an occupied new construction test house following construction of the house in the hot, humid climate of San Antonio, Texas. The project measures the effectiveness of a space conditioning strategy using a multihead mini-split heat pump (MSHP) system in a reduced-load home to achieve acceptable comfort levels (temperature and humidity) and energy performance. IBACOS collected long-term data and analyzed the energy consumption and comfort conditions of the occupied house after one year of operation. Although measured results indicate that the test system provides comfort both inside and outside the ASHRAE Standard 55-2010 range, the occupants of the house claimed both adequate comfort and appreciation of the ease of use and flexibility of the installed MSHP system. IBACOS also assisted the builder to evaluate design and specification changes necessary to comply with Zero Energy Ready Home, but the builder chose to not move forward with it because of concerns about the 'solar ready' requirements of the program.

  7. Aerial radiometric and magnetic survey: San Antonio National Topographic Map, Texas. Final report

    International Nuclear Information System (INIS)

    1980-05-01

    The results of analyses of the airborne gamma radiation and total magnetic field survey flown for the region identified as the San Antonio National Topographic Map NH14-8 are presented. The airborne data gathered are reduced by ground computer facilities to yield profile plots of the basic uranium, thorium, and potassium equivalent gamma radiation intensities, ratios of these intensities, aircraft altitude above the earth's surface, total gamma ray and earth's magnetic field intensity, correlated as a function of geologic units. The distribution of data within each geologic unit, for all surveyed map lines and tie lines, has been calculated and is included. Two sets of profiled data for each line are included, with one set displaying the above-cited data. The second set includes only flight line magnetic field, temperature, pressure, altitude data plus magnetic field data as measured at a base station. A general description of the area, including descriptions of the various geologic units and the corresponding airborne data, is included also

  8. Como güelfos y gibelinos: los colegios de San Bernardo y San Antonio Abad en el Cuzco durante el siglo XVII

    Directory of Open Access Journals (Sweden)

    Guibovich Pérez, Pedro M

    2006-04-01

    Full Text Available This article deals with the conflicts that involved the San Bernardo and San Antonio schools all along the seventeenth century. The author proposes a new approach to explain the social history of colonial Cuzco. He mantains that the root of the confrontation has to do with the privileges that enjoy the jesuits in the provision of academical degrees, a basic requirement to obtain appointments in the civil and eclesiastical administration. To understand this social dinamic, he reconstructs the institutional history of both schools, and reveals the interests that defend the main actors of this secular conflict.

    Los conflictos que enfrentaron a los colegios de San Bernardo y San Antonio Abad a lo largo del siglo XVII es el tema central de estudio de este ensayo. El autor propone una nueva lectura a este episodio de la historia social del Cuzco colonial. Sostiene que en la raíz de los enfrentamientos estuvo el privilegio que gozaban los jesuitas para la concesión de grados académicos, requisitos fundamentales para obtener cargos en la administración civil y eclesiástica. Para entender la dinámica social, el autor reconstruye la historia institucional de los colegios y los intereses en juego de los principales protagonistas del secular conflicto.

  9. Attractiveness of botanical infusions to ovipositing Culex quinquefasciatus, Cx. nigripalpus, and Cx. erraticus in San Antonio, Texas.

    Science.gov (United States)

    McPhatter, Lee P; Debboun, Mustapha

    2009-12-01

    Field experiments were conducted on the Fort Sam Houston Military Reservation, San Antonio, TX, in fall 2008 to observe the attractiveness of selected botanical infusions to ovipositing female mosquitoes. The following infusions were tested in Centers for Disease Control and Prevention gravid traps: Bermuda grass (Cynodon dactylon), oak leaf (Quercus virginiana), acacia leaf (Acacia schaffneri), rabbit chow (alfalfa pellets), and algae (Spirogyra sp.). Four (Bermuda, acacia, oak, and algae) of the 5 infusions were effective in collecting Culex quinquefasciatus, Cx. nigripalpus, and Cx. erraticus. Of the 4 infusions, Bermuda collected the greatest number of the mosquitoes sampled. Female Aedes albopictus mosquitoes were collected in moderate numbers during this study.

  10. Report on investigations in fiscal 2000 on the basic investigation on promotion of joint implementation. Rehabilitation of ICE/SAN ANTONIO power plant; 2000 nendo kyodo jisshi nado suishin kiso chosa hokokusho. ICE/SAN ANTONIO hatsudensho rihabiri

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-03-01

    Costa Rica takes a power generation system using hydro power generation as the main source, and possesses medium-capacity gas turbines to supplement needs in the dry season and the peak load. However, a problem has come up that, in addition to the cost rise in gas turbine fuel, the power generation efficiency has been aggravating due to aged deterioration of the generators being used. In association therewith, the problem is now a factor to increase CO2 emission, which is a worldwide problem. Keeping in mind to link it to the clean development mechanism (CDM), the present project is, taking up the SAN ANTONIO power plant as the investigation object, intended to perform a comprehensive discussion on the CO2 emission reducing effect, profitability, and proliferation effect, by executing the conceptual plant design. The up-grading plan for thermal power generation systems in Costa Rica consists of replacement of the gas turbines, handling of phase modifiers, and achievement of the combined cycle. The plan agrees with the present feasibility study intended of CO2 emission reduction, consisting of the modification plan of the SAN ANTONIO power plant, that is the plan to replace the over-aged gas turbines at the power plant. Its necessity has been identified. It was disclosed that the project has the effects of reducing CO2 of 82,000 tons annually, and the investment can be recovered in nine years. (NEDO)

  11. Occurrence of the haemocyte parasite Bonamia sp. in flat oysters Ostrea puelchana farmed in San Antonio Bay (Argentina).

    Science.gov (United States)

    Kroeck, Marina A; Montes, Jaime

    2005-02-28

    Culture of native flat oysters Ostrea puelchana d'Orbigny in San Antonio Bay (San Matías Gulf, Argentina) began in 1995. After elevated mortality (33%) occurred in September 1996, 18 mo after immersion, histopathological analysis and evaluation of parasitic prevalence was carried out. In October 1997, after 31 mo of cultivation, cumulative mortality was 80%, and in December of the same year, when individuals reached marketable size, mortality was 95% and culture was discontinued. The present study describes the haemocytic parasitism that affected O. puelchana, and suggests that a Bonamia sp. was the etiological agent. This parasite should be considered as a different species from Bonamia sp. detected in Australia and New Zealand until more studies are made to determine the correct taxonomy. This work constitutes the first record of this haemocyte parasite in flat oysters from the Argentinean coast.

  12. Calidad de atención y su influencia en el usuario externo en el centro de salud San Antonio de Pedregal 2015

    OpenAIRE

    Lozano Sotil, Ruth Consuelo

    2016-01-01

    El trabajo de investigación titulada “Calidad de atención y su influencia en el usuario externo en el Centro de Salud San Antonio de Pedregal Chosica 2015”se realizó con el objetivo de determinar el nivel de satisfacción del usuario externo sobre calidad de atención percibida en el Centro de Salud San Antonio de Pedregal 2015. La variable de estudio es calidad de atención en el usuario externo El estudio fué cuantitativo de tipo descriptivo transversal tuvo como población mu...

  13. Annual compilation and analysis of hydrologic data for Escondido Creek, San Antonio River basin, Texas

    Science.gov (United States)

    Reddy, D.R.

    1971-01-01

    IntroductionHistory of Small Watershed Projects in TexasThe U.S. Soil Conservation Service is actively engaged in the installation of flood and soil erosion reducing measures in Texas under the authority of the "Flood Control Act of 1936 and 1944" and "Watershed Protection and Flood Prevention Act" (Public Law 566), as amended. The Soil Conservation Service has found a total of approximately 3,500 floodwater-retarding structures to be physically and economically feasible in Texas. As of September 30, 1970, 1,439 of these structures had been built.This watershed-development program will have varying but important effects on the surface and ground-water resources of river basins, especially where a large number of the floodwater-retarding structures are built. Basic hydrologic data under natural and developed conditions are needed to appraise the effects of the structures on the yield and mode of occurrence of runoff.Hydrologic investigations of these small watersheds were begun by the Geological Survey in 1951 and are now being made in 12 study areas (fig. 1). These investigations are being made in cooperation with the Texas Water Development Board, the Soil Conservation Service, the San Antonio River Authority, the city of Dallas, and the Tarrant County Water Control and Improvement District No. 1. The 12 study areas were chosen to sample watershed having different rainfall, topography, geology, and soils. In five of the study areas, (North, Little Elm, Mukewater, little Pond-North Elm, and Pin Oak Creeks), streamflow and rainfall records were collected prior to construction of the floodwater-retarding structures, thus affording the opportunity for analyses of the conditions "before and after" development. A summary of the development of the floodwater-retarding structures in each study areas of September 30, 1970, is shown in table 1.Objectives of the Texas Small Watersheds ProjectThe purpose of these investigations is to collect sufficient data to meeting the

  14. Preliminary three-dimensional geohydrologic framework of the San Antonio Creek Groundwater Basin, Santa Barbara County, California

    Science.gov (United States)

    Cromwell, G.; Sweetkind, D. S.; O'leary, D. R.

    2017-12-01

    The San Antonio Creek Groundwater Basin is a rural agricultural area that is heavily dependent on groundwater to meet local water demands. The U.S. Geological Survey (USGS) is working cooperatively with Santa Barbara County and Vandenberg Air Force Base to assess the quantity and quality of the groundwater resources within the basin. As part of this assessment, an integrated hydrologic model that will help stakeholders to effectively manage the water resources in the basin is being developed. The integrated hydrologic model includes a conceptual model of the subsurface geology consisting of stratigraphy and variations in lithology throughout the basin. The San Antonio Creek Groundwater Basin is a relatively narrow, east-west oriented valley that is structurally controlled by an eastward-plunging syncline. Basin-fill material beneath the valley floor consists of relatively coarse-grained, permeable, marine and non-marine sedimentary deposits, which are underlain by fine-grained, low-permeability, marine sedimentary rocks. To characterize the system, surficial and subsurface geohydrologic data were compiled from geologic maps, existing regional geologic models, and lithology and geophysical logs from boreholes, including two USGS multiple-well sites drilled as part of this study. Geohydrologic unit picks and lithologic variations are incorporated into a three-dimensional framework model of the basin. This basin (model) includes six geohydrologic units that follow the structure and stratigraphy of the area: 1) Bedrock - low-permeability marine sedimentary rocks; 2) Careaga Formation - fine to coarse grained near-shore sandstone; 3) Paso Robles Formation, lower portion - sandy-gravely deposits with clay and limestone; 4) Paso Robles Formation, middle portion - clayey-silty deposits; 5) Paso Robles Formation, upper portion - sandy-gravely deposits; and 6) recent Quaternary deposits. Hydrologic data show that the upper and lower portions of the Paso Robles Formation are

  15. Simulation of flow in the Edwards Aquifer, San Antonio region, Texas, and refinement of storage and flow concepts

    Science.gov (United States)

    Maclay, Robert W.; Land, Larry F.

    1988-01-01

    The Edwards aquifer is a complexly faulted, carbonate aquifer lying within the Balcones fault zone of south-central Texas. The aquifer consists of thin- to massive-bedded limestone and dolomite, most of which is in the form of mudstones and wackestones. Well-developed secondary porosity has formed in association with former erosional surfaces within the carbonate rocks, within dolomitized-burrowed tidal and evaporitic deposits, and along inclined fractures to produce an aquifer with transmissivities greater than 100 ft2/s. The aquifer is recharged mainly by streamflow losses in the outcrop area of the Edwards aquifer and is discharged by major springs located at considerable distances, as much as 150 mi, from the areas of recharge and by wells. Ground-water flow within the Edwards aquifer of the San Antonio region was simulated to investigate concepts relating to the storage and flow characteristics. The concepts of major interest were the effects of barrier faults on flow direction, water levels, springflow, and storage within the aquifer. A general-purpose, finite-difference model, modified to provide the capability of representing barrier faults, was used to simulate ground-water flow and storage in the aquifer. The approach in model development was to conduct a series of simulations beginning with a simple representation of the aquifer framework and then proceeding to subsequent representations of increasing complexity. The simulations investigated the effects of complex geologic structures and of significant changes in transmissivity, anisotropy, and storage coefficient. Initial values of transmissivity, anisotropy, and storage coefficient were estimated based on concepts developed in previous studies. Results of the simulations confirmed the original estimates of transmissivity values (greater than 100 square feet/s) in the confined zone of the aquifer between San Antonio and Comal Springs. A storage coefficient of 0.05 in the unconfined zone of the aquifer

  16. [B_Erandio_Martiartu] Documentación del conjunto formado por la Torre de Martiartu y la ermita de San Antonio (Erandio, Bizkaia)

    OpenAIRE

    Álvarez González, Irantzu; Lopetegi Galarraga, Ane; Mesanza Moraza, Amaia; Rodríguez Miranda, Álvaro; Valle Melón, José Manuel

    2002-01-01

    [ES] El conjunto está formado por la torre de Martiartu (de unas 16 x 16 metros de planta), la pequeña ermita de la San Antonio y el área circundante. La documentación de la torre se realiza mediante fotogrametría estereoscópica y rectificación fotográfica para la obtención de las ortoimágenes. La ermita de San Antonio y el entorno se ha documentado mediante estación total y mallado para crear un modelo de superficies tridimensional. Posteriormente se presentan los modelos 3D y la colecció...

  17. ¿“Tierra de Gauchos” o “Gaucholandia”? Autenticidad en San Antonio de Areco (Argentina.

    Directory of Open Access Journals (Sweden)

    Cecilia Pérez Winter

    2016-01-01

    Full Text Available En este artículo proponemos analizar cómo la autenticidad es definida por diversos sujetos que se involucran en los procesos de valorización patrimonial y turística de una ciudad. En particular, cómo esa cualidad es disputada, discursiva y materialmente, a través del tiempo. Sostenemos que el discurso, o la idea de, autenticidad puede ser implementada por diferentes sectores de una comunidad, ya sea como un forma de legitimar/deslegitimar proyectos turísticos ‑patrimoniales, o para controlar la activación de los “patrimonios/atractivos”. Proponemos como estudio de caso la ciudad de San Antonio de Areco, localizada en la provincia de Buenos Aires ‑Argentina. Allí nos interesar indagar estos temas, a partir de examinar las tensiones que emergen entre las representaciones identitarias y la lógica turística/comercial, al mercantilizar elementos significativos asociados a la activación de un tipo de tradición y de gaucho.

  18. Simulations of groundwater flow and particle-tracking analysis in the zone of contribution to a public-supply well in San Antonio, Texas

    Science.gov (United States)

    Lindgren, Richard L.; Houston, Natalie A.; Musgrove, MaryLynn; Fahlquist, Lynne S.; Kauffman, Leon J.

    2011-01-01

    In 2006, a public-supply well in San Antonio, Texas, was selected for intensive study to assess the vulnerability of public-supply wells in the Edwards aquifer to contamination by a variety of compounds. A local-scale, steady-state, three-dimensional numerical groundwater-flow model was developed and used in this study to evaluate the movement of water and solutes from recharge areas to the selected public-supply well. Particle tracking was used to compute flow paths and advective traveltimes throughout the model area and to delineate the areas contributing recharge and zone of contribution for the selected public-supply well.

  19. Work to diminish the danger of forest fires in the municipalities San Antonio del Sur and Imías, Guantánamo

    OpenAIRE

    Edelmys Perez Pereda; Lianet Ramírez Fernández; Jessika Massó Matos; Francisco Duran Manual

    2017-01-01

    The research was carried out in the forest patrimony in San Antonio and Imías municipality in the province of Guantánamo, with the aim to propose actions to diminish the occurrence and propagation of the forest fires in the municipalities objects of study. For this, the temporal distribution of fires and burned areas, in the period 2006-2015, through the year, the week and the day was taken into account and also the causes that povoque the fires. With these elements, the activities to be carr...

  20. U.S. Geological Survey Karst Interest Group Proceedings, San Antonio, Texas, May 16–18, 2017

    Science.gov (United States)

    Kuniansky, Eve L.; Spangler, Lawrence E.

    2017-05-15

    Buffalo National River in the southern Ozarks, and a keynote presentation on paleokarst in the United States was delivered by Art and Peggy Palmer. The sixth KIG workshop was hosted by the National Cave and Karst Research Institute (NCKRI) in 2014, in Carlsbad, New Mexico. George Veni, Director of the NCKRI, served as a co-chair of the workshop with Eve Kuniansky of the USGS. The workshop featured speaker Dr. Penelope Boston, Director of Cave and Karst Studies at New Mexico Tech, Socorro, and Academic Director at the NCKRI, who addressed the future of karst research. The field trip on evaporite karst of the lower Pecos Valley was led by Lewis Land (NCKRI karst hydrologist), and the field trip on the geology of Carlsbad Caverns National Park was led by George Veni.This current seventh KIG workshop is being held in San Antonio at the University of Texas at San Antonio (UTSA). This 2017 workshop is being hosted by the Department of Geological Sciences’ Student Geological Society (SGS), and student chapters of the American Association of Petroleum Geologists (AAPG) and Association of Engineering Geologists (AEG), with support by the UTSA Department of Geological Sciences and Center for Water Research. The UTSA student chapter presidents, Jose Silvestre (SGS), John Cooper (AAPG), and Tyler Mead (AEG) serve as co-chairs of the 2017 workshop with Eve Kuniansky of the USGS. The technical session committee is chaired by Eve Kuniansky, USGS, and includes Michael Bradley, Tom Byl, Rebecca Lambert, John Lane, and James Kaufmann, all USGS, and Patrick Tucci, retired USGS. The logistics committee includes Amy Clark, Yongli Gao, and Lance Lambert (Department Chair), UTSA Department of Geological Sciences; and Ryan Banta and Allan Clark, USGS, San Antonio, Texas. The field trip committee is chaired by Allan Clark and includes Amy Clark, Yongli Gao, and Keith Muehlestein, UTSA; Marcus Gary, Edwards Aquifer Authority and University of Texas at Austin; Ron Green, Southwest Research

  1. Assessing the vulnerability of public-supply wells to contamination—Edwards aquifer near San Antonio, Texas

    Science.gov (United States)

    Jagucki, Martha L.; Musgrove, MaryLynn; Lindgren, Richard J.; Fahlquist, Lynne; Eberts, Sandra M.

    2011-01-01

    This fact sheet highlights findings from the vulnerability study of a public-supply well field in San Antonio, Texas. The well field consists of six production wells that tap the Edwards aquifer. Typically, one or two wells are pumped at a time, yielding an average total of 20-21 million gallons per day. Water samples were collected from public-supply wells in the well field and from monitoring wells installed along general directions of flow to the well field. Samples from the well field contained some constituents of concern for drinking-water quality, including nitrate; the pesticide compounds atrazine, deethylatrazine, and simazine; and the volatile organic compounds tetrachloroethene (also called perchloroethene, or PCE), chloroform, bromoform, and dibromochloromethane. These constituents were detected in untreated water at concentrations much less than established drinking-water standards, where such standards exist. Overall, the study findings point to four primary factors that affect the movement and fate of contaminants and the vulnerability of the public-supply well field in San Antonio, Texas: (1) groundwater age (how long ago water entered, or recharged, the aquifer), (2) fast pathways for flow of groundwater through features formed or enlarged by dissolution of bedrock, (3) recharge characteristics of the aquifer, and (4) natural geochemical processes within the aquifer. A computer-model simulation of groundwater flow and transport was used to estimate the traveltime (or age) of water particles entering public-supply well W4 in the well field. Modeled findings show that almost half of the water reaching the public-supply well is less than 2 years old. Such a large percentage of very young water indicates that (1) contaminants entering the aquifer may be transported rapidly to the well, (2) there is limited time for chemical reactions to occur in the aquifer that may attenuate contaminants, and (3) should recharge water become contaminated with

  2. Updated numerical model with uncertainty assessment of 1950-56 drought conditions on brackish-water movement within the Edwards aquifer, San Antonio, Texas

    Science.gov (United States)

    Brakefield, Linzy K.; White, Jeremy T.; Houston, Natalie A.; Thomas, Jonathan V.

    2015-01-01

    In 2010, the U.S. Geological Survey, in cooperation with the San Antonio Water System, began a study to assess the brackish-water movement within the Edwards aquifer (more specifically the potential for brackish-water encroachment into wells near the interface between the freshwater and brackish-water transition zones, referred to in this report as the transition-zone interface) and effects on spring discharge at Comal and San Marcos Springs under drought conditions using a numerical model. The quantitative targets of this study are to predict the effects of higher-than-average groundwater withdrawals from wells and drought-of-record rainfall conditions of 1950–56 on (1) dissolved-solids concentration changes at production wells near the transition-zone interface, (2) total spring discharge at Comal and San Marcos Springs, and (3) the groundwater head (head) at Bexar County index well J-17. The predictions of interest, and the parameters implemented into the model, were evaluated to quantify their uncertainty so the results of the predictions could be presented in terms of a 95-percent credible interval.

  3. Comportamiento del cáncer cérvicouterino en el municipio San Antonio del Sur de Guantánamo

    OpenAIRE

    Salvent Tames, Adrian; Rodríguez Lara, Osvaldo; Leyva Lambert, Marlenis; Gamboa Rodríguez, Mailin; Columbié Gámez, Mirta

    2012-01-01

    Introducción: no son pocos los esfuerzos que se realizan para combatir el cáncer cérvicouterino, a pesar de que existe un programa de detección precoz, estamos lejos aún de alcanzar la meta propuesta. Objetivo: conocer el comportamiento del cáncer cérvicouterino en el municipio de San Antonio del Sur de la provincia Guantánamo en el periodo 2006-2010. Métodos: el universo de estudio quedó constituido por las 254 pacientes que tuvieron una citología orgánica con diagnóstico positivo de lesione...

  4. Making lemonade from lemons: a case study on loss of space at the Dolph Briscoe, Jr. Library, University of Texas Health Science Center at San Antonio.

    Science.gov (United States)

    Tobia, Rajia C; Feldman, Jonquil D

    2010-01-01

    The setting for this case study is the Dolph Briscoe, Jr. Library, University of Texas Health Science Center at San Antonio, a health sciences campus with medical, dental, nursing, health professions, and graduate schools. During 2008-2009, major renovations to the library building were completed including office space for a faculty development department, multipurpose classrooms, a 24/7 study area, study rooms, library staff office space, and an information commons. The impetus for changes to the library building was the decreasing need to house collections in an increasingly electronic environment, the need for office space for other departments, and growth of the student body. About 40% of the library building was remodeled or repurposed, with a loss of approximately 25% of the library's original space. Campus administration proposed changes to the library building, and librarians worked with administration, architects, and construction managers to seek renovation solutions that meshed with the library's educational mission.

  5. Regional scale flood modeling using NEXRAD rainfall, GIS, and HEC-HMS/RAS: a case study for the San Antonio River Basin Summer 2002 storm event.

    Science.gov (United States)

    Knebl, M R; Yang, Z-L; Hutchison, K; Maidment, D R

    2005-06-01

    This paper develops a framework for regional scale flood modeling that integrates NEXRAD Level III rainfall, GIS, and a hydrological model (HEC-HMS/RAS). The San Antonio River Basin (about 4000 square miles, 10,000 km2) in Central Texas, USA, is the domain of the study because it is a region subject to frequent occurrences of severe flash flooding. A major flood in the summer of 2002 is chosen as a case to examine the modeling framework. The model consists of a rainfall-runoff model (HEC-HMS) that converts precipitation excess to overland flow and channel runoff, as well as a hydraulic model (HEC-RAS) that models unsteady state flow through the river channel network based on the HEC-HMS-derived hydrographs. HEC-HMS is run on a 4 x 4 km grid in the domain, a resolution consistent with the resolution of NEXRAD rainfall taken from the local river authority. Watershed parameters are calibrated manually to produce a good simulation of discharge at 12 subbasins. With the calibrated discharge, HEC-RAS is capable of producing floodplain polygons that are comparable to the satellite imagery. The modeling framework presented in this study incorporates a portion of the recently developed GIS tool named Map to Map that has been created on a local scale and extends it to a regional scale. The results of this research will benefit future modeling efforts by providing a tool for hydrological forecasts of flooding on a regional scale. While designed for the San Antonio River Basin, this regional scale model may be used as a prototype for model applications in other areas of the country.

  6. Work to diminish the danger of forest fires in the municipalities San Antonio del Sur and Imías, Guantánamo

    Directory of Open Access Journals (Sweden)

    Edelmys Perez Pereda

    2017-08-01

    Full Text Available The research was carried out in the forest patrimony in San Antonio and Imías municipality in the province of Guantánamo, with the aim to propose actions to diminish the occurrence and propagation of the forest fires in the municipalities objects of study. For this, the temporal distribution of fires and burned areas, in the period 2006-2015, through the year, the week and the day was taken into account and also the causes that povoque the fires. With these elements, the activities to be carried out to reduce the occurrence and propagation of forest fires were planned. The data were obtained in the fire reports of the CGB of Guantánamo province. Among the significant results train, the recent years the number of fire events has increased, most of them occur between march and may; usually from 8:00 am to 9:00 pm and the weekend is where there is the greatest risk of occurrence. The general cause that provoque the greatest number of fires is negligence. Therefore, it is necessary to implement an adequate protection plan against fire making great emphasis on the prevention of fires provoqued by humans and to take measures to modify the structure and composition of the combustible material.

  7. Mecenazgo religioso y estrategias familiares en la Segovia del siglo XV: Diego Árias de Ávila y el Hospital de San Antonio

    Directory of Open Access Journals (Sweden)

    Rábade Obradó, María del Pilar

    2002-12-01

    Full Text Available The present work studies the foundation of Saint Anthony´s hospital of Segovia during the XVth century. The foundation was an initiative of Diego Arias de Ávila, one of the most influential personalities of the reign of Henry IV of Castila. The foundation was determined on very varied reasons, not only charitative and religious reasons. Among these reasons, the use of the hospital as an instrument of the family strategies. These family strategies tried to hidden the hebrew origins of the lineage. They also tried to guarantee the perennity of the lineage, and to leave an endurable memory behind. Lasdy, these family strategies tried to consolidate the domination that the lineage had on Segovia.

    El presente trabajo estudia la fundación del hospital de San Antonio de Segovia en el siglo XV. La fundación fue una iniciativa de Diego Arias de Ávila, uno de los personajes más influyentes durante el reinado de Enrique IV de Castilla. La fundación estuvo determinada por motivaciones muy diversas, no sólo caritativas y religiosas. Entre ellas, el uso del hospital como instrumento de las estrategias familiares. Esas estrategias familiares pretendían ocultar los orígenes judíos del linaje, garantizar su perennidad, dejar una memoria perdurable del mismo, y, finalmente, consolidar la dominación que el linaje ejercía sobre Segovia.

  8. Magmatic controls on eruption dynamics of the 1950 yr B.P. eruption of San Antonio Volcano, Tacaná Volcanic Complex, Mexico-Guatemala

    Science.gov (United States)

    Mora, Juan Carlos; Gardner, James Edward; Macías, José Luis; Meriggi, Lorenzo; Santo, Alba Patrizia

    2013-07-01

    San Antonio Volcano, in the Tacaná Volcanic Complex, erupted ~ 1950 yr. B.P., with a Pelean type eruption that produced andesitic pyroclastic surges and block-and-ash flows destroying part of the volcano summit and producing a horse-shoe shaped crater open to the SW. Between 1950 and 800 yr B.P. the eruption continued with effusive andesites followed by a dacite lava flow and a summit dome, all from a single magma batch. All products consist of phenocrysts and microphenocrysts of zoned plagioclase, amphibole, pyroxene, magnetite ± ilmenite, set in partially crystallized groundmass of glass and microlites of the same mineral phases, except for the lack of amphibole. Included in the andesitic blocks of the block-and-ash flow deposit are basaltic andesite enclaves with elongated and ellipsoidal forms and chilled margins. The enclaves have intersertal textures with brown glass between microphenocrysts of plagioclase, hornblende, pyroxene, and olivine, and minor proportions of phenocrysts of plagioclase, hornblende, and pyroxene. A compositional range obtained of blocks and enclaves resulted from mixing between andesite (866 °C ± 22) and basaltic andesite (enclaves, 932 °C ± 22), which may have triggered the explosive Pelean eruption. Vestiges of that mixing are preserved as complex compositional zones in plagioclase and clinopyroxene-rich reaction rims in amphibole in the andesite. Whole-rock chemistry, geothermometry, experimental petrology and modeling results suggest that after the mixing event the eruption tapped hybrid andesitic magma (≤ 900 °C) and ended with effusive dacitic magma (~ 825 °C), all of which were stored at ~ 200 MPa water pressure. A complex open-system evolution that involved crustal end-members best explains the generation of effusive dacite from the hybrid andesite. Amphibole in the dacite is rimmed by reaction products of plagioclase, orthopyroxene, and Fe-Ti oxides produced by decompression during ascent. Amphibole in the andesite

  9. Specialty education in periodontics in Japan and the United States: comparison of programs at Nippon Dental University Hospital and the University of Texas Health Science Center at San Antonio.

    Science.gov (United States)

    Osawa, Ginko; Nakaya, Hiroshi; Mealey, Brian L; Kalkwarf, Kenneth; Cochran, David L

    2014-03-01

    Japan has institutions that train qualified postdoctoral students in the field of periodontics; however, Japan does not have comprehensive advanced periodontal programs and national standards for these specialty programs. To help Japanese programs move toward global standards in this area, this study was designed to describe overall differences in periodontics specialty education in Japan and the United States and to compare periodontics faculty members and residents' characteristics and attitudes in two specific programs, one in each country. Periodontal faculty members and residents at Nippon Dental University (NDU) and the University of Texas Health Science Center at San Antonio (UTHSCSA) Dental School participated in the survey study: four faculty members and nine residents at NDU; seven faculty members and thirteen residents at UTHSCSA. Demographic data were collected as well as respondents' attitudes toward and assessment of their programs. The results showed many differences in curriculum structure and clinical performance. In contrast to the UTHSCSA respondents, for example, the residents and faculty members at NDU reported that they did not have enough subject matter and time to learn clinical science. Although the residents at NDU reported seeing more total patients in one month than those at UTHSCSA, they were taught fewer varieties of periodontal treatments. To provide high-quality and consistent education for periodontal residents, Japan needs to establish a set of standards that will have positive consequences for those in Japan who need periodontal treatment.

  10. The business and technical case for Continuous Commissioning(reg Trade Mark) for enhanced building operations. A case study: Alamo Community College District San Antonio, Texas, U.S.A

    Energy Technology Data Exchange (ETDEWEB)

    Verdict, Malcolm; Wei, Guanghua [Texas A and M Univ. System, College Station, TX (United States). Energy Systems Laboratory

    2005-07-01

    This paper provides both the business and technical cases for the 'Continuous Commissioning' of large [>25,000 square feet], buildings through a whole building diagnostic and HVAC optimization approach known as 'Continuous Commissioning'. 'Continuous Commissioning' is defined as the ongoing engineering process to resolve operating problems, improve comfort, optimize energy use and identify retrofits in existing buildings and central plant facilities. It is also known as 'building retro-commissioning' or 'building tune-up'. It involves a rigorous, whole-building, engineering evaluation of the heating and cooling systems to identify mechanical problems, inadequate or ineffective control strategies. Some of the most common problems are: 1) Improper calibration of sensors and metering, 2) inadequate control strategies for optimum operation and comfort, 3) incorrect scheduling of heating and cooling equipment, 4) lack of air and water-side economizer equipment, 5) inadequate building automation systems, and 6) inadequate operations and maintenance. The CC process, described in this paper, was successfully applied at Alamo Community College District (ACCD) in San Antonio, Texas, USA by the Energy Systems Laboratory (ESL), a part of the Texas A and M Univ. System. ACCD has multiple buildings on 4 campuses with total conditioned area of 2.35 Million square feet. ACCD's business approach was unique because the cost of conducting the CC process was financed as an Energy Cost Reduction Measure (ECRM) along with several energy efficiency retrofits.

  11. Influencia de los patrones de uso actual de la tierra sobre la dinámica de la vegetación en el páramo de Rabanal, vereda San Antonio, municipio de Guachetá

    Directory of Open Access Journals (Sweden)

    Luis Miguel Borrás S.

    2010-10-01

    Full Text Available The patterns of current land use in the Rabanal paramo suggest a slow and progressive deterioration of the vegetation of this ecosystem, probably due to the current practice of disturbances imposed apparently largely by human causes, mainly the expansion of the agricultural frontier (mechanized potato crops and grazing. The typical situation of the pattern of occupation and land-holding in these places, as well as the established production system, is the starting point to determine its effect on this sector of the Rabanal paramo ecosystem and define whether or not this fact is crucial to its conservation and management.The study was conducted in three stages that included the characterization of the area done through surveys, a review of primary and secondary education, followed by field work, and final tabulation of information.The present study obtained results which were intended to contribute to the knowledge of current land use in a sector of the settlement of San Antonio - Township Guachetá, bordering the Rabanal Paramo and with this give the necessary foundation for understanding how anthropogenic intervention operates in the area and its implications for vegetation dynamics and knowledge of its production systems.

  12. Geochemical evolution processes and water-quality observations based on results of the National Water-Quality Assessment Program in the San Antonio segment of the Edwards aquifer, 1996-2006

    Science.gov (United States)

    Musgrove, MaryLynn; Fahlquist, Lynne; Houston, Natalie A.; Lindgren, Richard J.; Ging, Patricia B.

    2010-01-01

    As part of the National Water-Quality Assessment Program, the U.S. Geological Survey collected and analyzed groundwater samples during 1996-2006 from the San Antonio segment of the Edwards aquifer of central Texas, a productive karst aquifer developed in Cretaceous-age carbonate rocks. These National Water-Quality Assessment Program studies provide an extensive dataset of groundwater geochemistry and water quality, consisting of 249 groundwater samples collected from 136 sites (wells and springs), including (1) wells completed in the shallow, unconfined, and urbanized part of the aquifer in the vicinity of San Antonio (shallow/urban unconfined category), (2) wells completed in the unconfined (outcrop area) part of the regional aquifer (unconfined category), and (3) wells completed in and springs discharging from the confined part of the regional aquifer (confined category). This report evaluates these data to assess geochemical evolution processes, including local- and regional-scale processes controlling groundwater geochemistry, and to make water-quality observations pertaining to sources and distribution of natural constituents and anthropogenic contaminants, the relation between geochemistry and hydrologic conditions, and groundwater age tracers and travel time. Implications for monitoring water-quality trends in karst are also discussed. Geochemical and isotopic data are useful tracers of recharge, groundwater flow, fluid mixing, and water-rock interaction processes that affect water quality. Sources of dissolved constituents to Edwards aquifer groundwater include dissolution of and geochemical interaction with overlying soils and calcite and dolomite minerals that compose the aquifer. Geochemical tracers such as magnesium to calcium and strontium to calcium ratios and strontium isotope compositions are used to evaluate and constrain progressive fluid-evolution processes. Molar ratios of magnesium to calcium and strontium to calcium in groundwater typically

  13. Femoral Artery Atherosclerosis Is Associated With Physical Function Across the Spectrum of the Ankle-Brachial Index: The San Diego Population Study.

    Science.gov (United States)

    Wassel, Christina L; Ellis, Alicia M; Suder, Natalie C; Barinas-Mitchell, Emma; Rifkin, Dena E; Forbang, Nketi I; Denenberg, Julie O; Marasco, Antoinette M; McQuaide, Belinda J; Jenny, Nancy S; Allison, Matthew A; Ix, Joachim H; Criqui, Michael H

    2017-07-20

    The ankle-brachial index (ABI) is inadequate to detect early-stage atherosclerotic disease, when interventions to prevent functional decline may be the most effective. We determined associations of femoral artery atherosclerosis with physical functioning, across the spectrum of the ABI, and within the normal ABI range. In 2007-2011, 1103 multiethnic men and women participated in the San Diego Population Study, and completed all components of the summary performance score. Using Doppler ultrasound, superficial and common femoral intima media thickness and plaques were ascertained. Logistic regression was used to assess associations of femoral atherosclerosis with the summary performance score and its individual components. Models were adjusted for demographics, lifestyle factors, comorbidities, lipids, and kidney function. In adjusted models, among participants with a normal-range ABI (1.00-1.30), the highest tertile of superficial intima media thickness was associated with lower odds of a perfect summary performance score of 12 (odds ratio=0.56 [0.36, 0.87], P =0.009), and lower odds of a 4-m walk score of 4 (0.34 [0.16, 0.73], P =0.006) and chair rise score of 4 (0.56 [0.34, 0.94], P =0.03). Plaque presence (0.53 [0.29, 0.99], P =0.04) and greater total plaque burden (0.61 [0.43, 0.87], P =0.006) were associated with worse 4-m walk performance in the normal-range ABI group. Higher superficial intima media thickness was associated with lower summary performance score in all individuals ( P =0.02). Findings suggest that use of femoral artery atherosclerosis measures may be effective in individuals with a normal-range ABI, especially, for example, those with diabetes mellitus or a family history of peripheral artery disease, when detection can lead to earlier intervention to prevent functional declines and improve quality of life. © 2017 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.

  14. Calidad de los Servicios Académicos y Administrativos de la Facultad de Ciencias Sociales de la Universidad Nacional de San Antonio Abad del Cusco, Según la Percepción del Personal docente y estudiantes, Año 2015

    OpenAIRE

    Vargas Béjar, Juan Fernando

    2017-01-01

    La calidad de los servicios académicos y administrativos de la Facultad de Ciencias Sociales de la Universidad Nacional de San Antonio Abad del Cusco (UNSAAC), es un tema que será visto desde el enfoque de los docentes y estudiantes quienes brindan la información necesaria para poder comprender la estructura de dichos servicios y si éstos son utilizados coherentemente. Las actividades dentro de la mencionada Facultad, representan el ámbito académico y administrativo para el adecuado desemp...

  15. Antonio Lupi maailm

    Index Scriptorium Estoniae

    2008-01-01

    Vannitoa mööbli, peeglite, vannide, kraanikausside ja aksessuaaride valmistamisele spetsialiseerunud Antonio Lupi tehasest Itaalias. Koostööd tehakse itaalia disaineritega, nagu Carlo Colombo, Mauro Carlesi, Nevio Tellatin, Anne ja Patrick Poirier. Eestis saab tootenäidistega tutvuda salongis Gerhard Vannitoad (Maakri 19/21, Tallinn)

  16. San Antonio's 1983 Bus Passenger Survey

    Science.gov (United States)

    1983-10-01

    Many transit operators routinely collect ridership data in order to provide a : basis for the planning of bus services. Often a survey is conducted of bus : riders to determine their riding habits, their views about the quality of : current service, ...

  17. Water-quality observations of the San Antonio segment of the Edwards aquifer, Texas, with an emphasis on processes influencing nutrient and pesticide geochemistry and factors affecting aquifer vulnerability, 2010–16

    Science.gov (United States)

    Opsahl, Stephen P.; Musgrove, MaryLynn; Mahler, Barbara J.; Lambert, Rebecca B.

    2018-06-07

    As questions regarding the influence of increasing urbanization on water quality in the Edwards aquifer are raised, a better understanding of the sources, fate, and transport of compounds of concern in the aquifer—in particular, nutrients and pesticides—is needed to improve water management decision-making capabilities. The U.S. Geological Survey, in cooperation with the San Antonio Water System, performed a study from 2010 to 2016 to better understand how water quality changes under a range of hydrologic conditions and in contrasting land-cover settings (rural and urban) in the Edwards aquifer. The study design included continuous hydrologic monitoring, continuous water-quality monitoring, and discrete sample collection for a detailed characterization of water quality at a network of sites throughout the aquifer system. The sites were selected to encompass a “source-to-sink” (that is, from aquifer recharge to aquifer discharge) approach. Network sites were selected to characterize rainfall, recharging surface water, and groundwater; groundwater sites included wells in the unconfined part of the aquifer (unconfined wells) and in the confined part of the aquifer (confined wells) and a major discharging spring. Storm-related samples—including rainfall samples, stormwater-runoff (surface-water) samples, and groundwater samples—were collected to characterize the aquifer response to recharge.Elevated nitrate concentrations relative to national background values and the widespread detection of pesticides indicate that the Edwards aquifer is vulnerable to contamination and that vulnerability is affected by factors such as land cover, aquifer hydrogeology, and changes in hydrologic conditions. Greater vulnerability of groundwater in urban areas relative to rural areas was evident from results for urban groundwater sites, which generally had higher nitrate concentrations, elevated δ15N-nitrate values, a greater diversity of pesticides, and higher pesticide

  18. Entrevista com Antonio Candido

    Directory of Open Access Journals (Sweden)

    Pontes Heloisa

    2001-01-01

    Full Text Available Concedida em agosto de 1987, revista pelo autor em julho de 2001, esta entrevista aborda dimensões relevantes da trajetória intelectual de Antonio Candido. Por meio do rastreamento do impacto da revolução de 1930 na cultura brasileira e do papel decisivo que a fundação da Faculdade de Filosofia da Universidade de São Paulo teve na implantação de um novo padrão de trabalho intelectual, Antonio Candido arma o contexto necessário para entendermos os desafios culturais e políticos perseguidos por ele e por figuras de ponta de sua geração, como Florestan Fernandes e vários dos integrantes do Grupo Clima. O resultado é uma imagem vívida e palpitante do caldo de cultura que permeou o processo de institucionalização das Ciências Sociais em São Paulo.

  19. Aplicación de canciones infantiles y su influencia en el aprendizaje del vocabulario del idioma francés en los niños del nivel inicial de la Institución Educativa San Antonio de Padua, Chosica - Lima 2016

    OpenAIRE

    Gómez Hermoza, Cecilia del Pilar

    2017-01-01

    Aplica las canciones infantiles en el aprendizaje del vocabulario del idioma francés en los niños del nivel inicial de la Institución Educativa San Antonio de Padua Chosica - Lima 2016. Se realiza un estudio cuasi experimental en el cual participan dos grupos, uno de 24 niños de 5 años del aula “A”, que constituyó el grupo de control y el otro, con 24 niños de 5 años del aula “B”, que conformó el cuasi experimental; se utilizan estrategias para el aprendizaje práctico asistido por la profesor...

  20. Antonio Mollari fra Canova e Valadier / Antonio Mollari between Canova and Valadier

    Directory of Open Access Journals (Sweden)

    Elisa Debenedetti

    2014-04-01

    Full Text Available Non è difficile inserire Antonio Mollari in un contesto europeo. Ad Antonio Canova lo lega una prima, importantissima lettera del 4 maggio 1807 nella quale, in seguito ad un invito trasmessogli dallo scultore, ma di cui è responsabile Filippo III Colonna, enumera tutte le sue opere; la seconda risale al 25 febbraio 1809. Dalla prima missiva si riescono a stabilire numerosi contatti con Giuseppe Valadier: a Corridonia (Collegiata dei Santi Pietro, Paolo e Donato; Ospedale e Chiesa di San Salvatore e a Macerata (Palazzo Conti già Ugolini. Tanto da giungere a considerare Mollari come il continuatore del Valadier nei cantieri marchigiani, dove la presenza del Maestro si manifesta come una sovrapposizione di motivi francesizzanti a soluzioni palladiane: componenti entrambe presenti nel Palazzo Tomassini a Corridonia, ricondotto al Maceratese. Fra l’altro le pagine di due Taccuini valadieriani, certo a lui note, si possono considerare a metà strada fra l’esercizio tipologico ed il modello. It’s not difficult to insert Antonio Mollari into a European context. A first very important letter, dated May 4th 1807, links him to Antonio Canova whereby, after inviting him, by wish of Phillip Colonna III , he then makes a list of all his works of art; the second is dated February 25th 1809. Various contacts with Giuseppe Valadier can be established from the first letter: in Corridonia (Saints Peter, Paul and Donato Collegiate church; St. Saviour’s Hospital and Church and in Macerata (Conti Palace ex Ugolini. So much so as to regard Mollari as Valadier’s continuator in the Marche construction sites, where the Maestro’s presence is expressed like a superimposition of Frenchified motives for Palladian solutions: both components being present in the Tomassini Palace in Corridonia, which can be traced back to Mollari. Moreover the pages of two Valdier Notebooks, which he must have known about, can be considered half way between a typological exercise

  1. Abetti, Antonio (1846-1928) and Abetti, Giorgio (1882-1982)

    Science.gov (United States)

    Murdin, P.

    2000-11-01

    Antonio was born in San Pietro di Gorizia, Italy. A civil engineer, he turned to astronomy and became director of the observatory in Arcetri and professor of astronomy at the University of Florence. His main interest was positional astronomy, observation of minor planets, comets and star occultations. In 1874 he observed the transit of Venus across the Sun's disk through a spectroscope. His son, ...

  2. Atherosclerosis VII

    International Nuclear Information System (INIS)

    Fidge, N.H.; Nestel, P.J.; Flinders Univ., Adelaide

    1986-01-01

    In these proceedings the major themes of the conference have been preserved and comprise epidemiology, lipoproteins, pathogenesis, and clinical, therapeutic and nutritional aspects. The diet-lipidcoronary artery disease hypothesis has been strengthened significantly. Several long-awaited trials, reviewed here, have provided very strong support for the rationale for treating hyperlipidemia. A strategy for the prevention of atherosclerosis was defined at the conference. The genesis of atherosclerosis was shown to be more firmly grounded in the influx of lipoprotein into the arterial wall. The regulation of these processes and the rapid advances made possible by new technology were detailed in several sessions. Important new developments in the clinical area and in pharmacology give promise of greatly improved management of established disease. However, the possibility of mounting large-scale preventive measures in the near future, was given credence in the epidemiology and nutrition workshops. (Auth.)

  3. 40 CFR 52.2285 - Control of evaporative losses from the filling of gasoline storage vessels in the Houston and San...

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 4 2010-07-01 2010-07-01 false Control of evaporative losses from the filling of gasoline storage vessels in the Houston and San Antonio areas. 52.2285 Section 52.2285... of gasoline storage vessels in the Houston and San Antonio areas. (a) Definitions: (1) Gasoline means...

  4. 33 CFR 110.74c - Bahia de San Juan, PR.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Bahia de San Juan, PR. 110.74c Section 110.74c Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.74c Bahia de San Juan, PR. The waters of San Antonio...

  5. Coastal Bend Texas Benthic Habitat - San Antonio Bay 2007 Substrate

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — In 2006 and 2007 the NOAA Office for Coastal Management purchased services to process existing digital multi-spectral imagery (ADS-40) and create digital benthic...

  6. LPD 17 San Antonio Class Amphibious Transport Dock (LPD 17)

    Science.gov (United States)

    2015-12-01

    Grumman’s shipbuilding division and deferred depreciation expenses for recovery of insurance proceeds associated with Hurricane Katrina damages. Contract...Safety and Health Administration and the Pension Protection Act. The government liability for deferred depreciation from Hurricane Katrina was...of engineering change proposals and negotiation of a contract price adjustment to cover the Navy’s share of deferred depreciation expenses for

  7. San Antonio Creek Restoration, Vandenberg Air Force Base, California

    Science.gov (United States)

    2008-06-27

    Vandenberg Air Force Base Scientific Name Common Name Scientific Name Common Name Sambucus mexicana Blue elderberry Sonchus oleraceus * Common sow... Sonchus oleraceus Common sow-thistle exotic NI Spergularia bocconii Sand-spurry exotic FAC Spergularia marina Sand-spurry native FACW...border the existing roads within the project area. Both weedy non-native species adapted to frequent disturbance, such as sow thistle ( Sonchus

  8. Inflammasomes and Atherosclerosis

    Directory of Open Access Journals (Sweden)

    S. Vallurupalli, MD

    2016-09-01

    Full Text Available Inflammation plays an important role in atherosclerosis. Inflammasomes play a crucial role in innate immunity, which mediates the body’s response to various pathogens. Of the different types of inflammasomes, NLRP3 has been implicated in atherosclerosis through the production of proinflammatory cytokines, IL-1β and IL-18. This review describes the role of the NLRP3 inflammasome in atherosclerosis and discusses potential therapeutic targets in the inflammasome pathway.

  9. Antonio Lopez: Fashion, Art, Sex & Disco

    DEFF Research Database (Denmark)

    Langkjær, Michael Alexander

    2014-01-01

    Book review. Roger Padilha and his brother Mauricio may already be familiar to some as the New York-based fashion publicists, creators of the fashion public relations agency MAO PR, and as authors of The Stephen Sprouse Book (Rizzoli, 2009). Antonio Lopez: Fashion, Art, Sex & Disco, their second...

  10. Vaccination against atherosclerosis

    NARCIS (Netherlands)

    Es, Thomas van

    2009-01-01

    Atherosclerosis, the predominantly underlying pathology of cardiovascular events, is the consequence of lipid deposition in the arterial wall, mostly as consequence of high levels of serum cholesterol. Treatment of atherosclerosis is mainly focused at the reduction of cholesterol levels by lipid

  11. Phytosterols and atherosclerosis

    DEFF Research Database (Denmark)

    Schrøder, Malene

    Cardiovascular disease (CVD) is the major cause of premature deaths worldwide. Coronary heart disease is the most common CVD, caused by atherosclerosis in the coronary arteries. Atherosclerosis is a multifactorial disease influenced by both genetic and environmental factors. WHO has in 2007 listed...... in its “Guidelines for assessment and management of cardiovascular risk” the following risk factors to influence progressive atherosclerosis: hypertension, abnormal blood lipids, diabetes, unhealthy diet, physical inactivity and smoking. Phytosterols (plant sterols and plant stanols) are known...... their blood cholesterol levels. The aim of this Ph.D. project was to investigate the effects of phytosterols on the development of atherosclerosis in the aorta of heterozygous Watanabe Heritable Hyperlipidemic (WHHL) rabbits. The main advantage of animal studies to human studies in atherosclerosis research...

  12. Cuadros de Juan del Castillo y Antonio del Castillo en el Ermitage

    Directory of Open Access Journals (Sweden)

    Kagané, L.

    2003-06-01

    Full Text Available Juan del Castillo y Antonio del Castillo son dos pintores que trabajaron en Andalucía. Hace algún tiempo se consideraba que Antonio era el sobrino de Juan, actualmente es sabido que no es así, aunque no se excluye que fuesen parientes. Al ingresar los cuadros de estos pintores en el Ermitage tuvo lugar una confusión debida al parecido de sus apellidos y las obras de uno de ellos se atribuían en los inventarios al otro. Así ocurrió con el pequeño cuadro Visitación (Fig. 1. Fue adquirido en 1834 a Juan Miguel Páez de la Cadena, embajador de España en San Petersburgo, e incluido en el catálogo manuscrito del museo sin haber indicado el nombre. En el Livret y en todos los posteriores catálogos del Ermitage de antes de la revolución, el cuadro fue asignado bajo el nombre de Antonio del Castillo…

  13. ANTONIO LAMELA - beyond innovation In Memory

    Directory of Open Access Journals (Sweden)

    P. Cassinello

    2018-01-01

    Full Text Available Spanish architecture is in mourning. One of its most beloved referents, Antonio Lamela passed away on April 1, 2017. He has left us an extensive and polyhedral legacy that continues to live in the urban fabric of our cities, in the pages of his books, and in the model of thought and action, which presided over by the effort and the desire to innovate, led him to reach the highest levels of our profession. A model with which he founded his office in 1954 and which today, directed for many years by his son Carlos Lamela, has a relevant international representation having carried out projects in 32 countries. Beyond the formal and technological innovation of his buildings, in the 1950s Antonio Lamela established in Spain companies such as Prebetong and Shokbeton to modernize Spanish construction, actively intervening in the necessary expansion of “Caja de Elementos of Construction” demanded by Le Corbusier since the twenties. Changing his perspective, Antonio Lamela has also bequeathed us his pioneering reflections on the proper management of natural resources and the necessary sustainability of the architecture of our planet within the cosmos in which it lives. He will always be an unavoidable model for future generations.

  14. Antonio Mollari, un problema di comunicazione / Antonio Mollari, a communication problem

    Directory of Open Access Journals (Sweden)

    Gianfranco Berchiesi

    2015-01-01

    Full Text Available La riscoperta della figura di Antonio Mollari, in seguito al ritrovamento presso il Comune di Petriolo di cinque sue tavole acquerellate, ebbe inizio con la mostra del 2006, nella quale l’esposizione di alcune delle più interessanti tavole conservate a Trieste, Foligno e Macerata e una conferenza del Prof. Cruciani Fabozzi, seguita dalla storia della famiglia Mollari ad opera dell’Ing. Carratù, delinearono un primo “ritratto” della personalità di Antonio Mollari. Da quella data è poi maturata l’idea di indagare in maniera più adeguata la sua attività, giungendo al Convegno tenuto all’Abbadia di Fiastra nel 2013. L’autore mette in evidenza come la figura di Antonio Mollari, al di là del giudizio tecnico che possono esprimere i relatori che si sono succeduti nel Convegno, ha un problema legato alla comunicazione. Chi era Mollari e come potrebbe essere adeguatamente presentato in una riunione di persone non addette ai lavori? Era architetto, ingegnere, tecnico? Oppure, alla bisogna, era l’una o l’altra di queste figure? In this report it is narrated that in 2006 the figure of Antonio Mollari was reproposed, after the discovery of five watercolor maps at the municipality of Petriolo, by means of a small exhibition to which Prof. Cruciani Fabozzi gave the right approach. From that date an interest in the idea of a more appropriate and extensive discussion on Antonio Mollari is later gained, reaching the Conference held in the Abbey of Fiastra in 2013. The author highlights how the figure of Antonio Mollari has a problem with the communication, beyond the technical opinion, expressed by the speakers that have taken place in the conference. Who was Mollari and how could he be adequately presented at a meeting of persons not qualified in this matter? It was Architect or Engineer? Or, as needed, was the one or the other of these figures?

  15. Atherosclerosis: Hypotheses and theories

    Directory of Open Access Journals (Sweden)

    E. A. Yuryeva

    2014-01-01

    Full Text Available The article gives basic theories of the pathogenesis of atherosclerosis, including inflammatory, cholesterol, lipid, lipoprotein, iron ones, as a result of metabolic syndrome, oxidative stress. In spite of carefully and deeply developed and ongoing elaborated pathogenesis theories, the etiological factors of atherosclerosis remain unknown so far. The age-related aspect of the disease is discussed; atherosclerosis is considered to be a childhood-onset disease that manifests itself at a later age. The authors propose an experimental and clinical evidence-based concept of the common etiology of syndromes of atherosclerosis, namely: the body's endogenous intoxication that is permanent or periodically progressive may be a primary cause of altered conformation of different protein molecules with their higher ability to adsorb the trace elements consolidating the structural changes. This change of proteins diminishes their functions and determines their antigenic properties, which is attended by the development of different pathogenic components in relation to the body's individual features.

  16. The Biochemistry of atherosclerosis

    National Research Council Canada - National Science Library

    Scanu, Angelo M; Getz, Godfrey S; Wissler, Robert W

    1979-01-01

    In this first full-length review of the biochemical parameters and their part in the pathogenesis of atherosclerosis, the reader will discover a range of coverage concerning basic etiological factors...

  17. La presidencia de Miguel Antonio Caro

    Directory of Open Access Journals (Sweden)

    Beatriz González

    2000-05-01

    Full Text Available Cien años de los mil días: Los mil días en treinta y dos pasos. Capítulo 2 El gobierno de Miguel Antonio Caro mantenía un ejército relativamente grande, de unos seis mil hombres. Para su reforma y organización trajo una misión francesa. En el ambiente belicista que se vivía en el país. se publicaron y reeditaron libros sobre la técnica del manejo de las armas.

  18. Antonio Caldara v kontextu své doby

    Czech Academy of Sciences Publication Activity Database

    Jonášová, Milada

    2016-01-01

    Roč. 24, č. 11 (2016), s. 36-37 ISSN 1210-9525. [Antonio Caldara im Kontext seiner Zeit. Český Krumlov, 17.09.2016-18.09.2016] Institutional support: RVO:68378076 Keywords : Antonio Caldara * conference * Český Krumlov * opera performance Subject RIV: AL - Art, Architecture, Cultural Heritage

  19. Antonio Porta and Seventeenth-Century Central European Architecture

    Czech Academy of Sciences Publication Activity Database

    Krummholz, Martin

    -, 0118 (2015), s. 1-24 ISSN 2190-3328 Institutional support: RVO:68378033 Keywords : Antonio Porta * Francesco Caratti * J. B. Mathey * architecture * palace * chateau * Vienna * Turin * F. Luchese * G. P. Tencalla * Roudnice nad Labem Subject RIV: AL - Art, Architecture , Cultural Heritage http://www.riha-journal.org/articles/2015/2015-jan-mar/krummholz-antonio-porta

  20. Antonio Ricci en Madrid: 1586-1635

    Directory of Open Access Journals (Sweden)

    García López, David

    2010-03-01

    Full Text Available Life of painter Antonio Ricci is studied by new documents from his arrived at Escorial with Federico Zuccari in 1586. Ricci worked in the Palace of Madrid and was involved in the birth of the Academy of Painting. Here are studied his work as Painter and Appraiser, or his portrait of Philip IV of Spain and his relationship with Jeronimo Gratti, Caballero de Gracia.

    Nuevas aportaciones documentales aclaran la vida del pintor Antonio Ricci en la Corte española desde su llegada a El Escorial junto a Federico Zuccari en 1586. Ricci trabajó como pintor en el entorno palaciego y estuvo involucrado desde el principio en el intento de creación de la Academia madrileña de pintores. Se detallan aquí su trabajo como tasador, su retrato del futuro Felipe IV o su cercana relación con un personaje tan singular como Jeronimo Gratti, el Caballero de Gracia.

  1. Juan Antonio Rubio Rodriguez (1944 – 2010)

    CERN Multimedia

    His colleagues and friends

    2010-01-01

    It was with deep sorrow and great sadness that we learnt that Juan Antonio Rubio Rodriguez had passed away on 16th January 2010. Juan Antonio was born in Madrid on 4th June 1944, and received his Ph. D. in Physics in 1971 from“Universidad Complutense de Madrid”. He was a CERN Fellow (1968 – 1971) and subsequently worked at JEN (currently CIEMAT) as a researcher (1971 – 1976). He was leader of the HEP group (1977 – 1981), leader of the Nuclear and Particle Physics Division (1981 – 1983), Director for Basic Research (1983 – 1987) and Scientific Director (1984 – 1987). He was instrumental in the Spanish accession to CERN approved by the Spanish Government at the end of 1982 and ratified by the Spanish Parliament in June 1983. He served at CERN (1987 – 2004) as Group Leader (1987 – 1990), Scientific Advisor to the Director-General (1990 – 2000) and as Division Leader of the Education and Technology T...

  2. Nuclear medicine and atherosclerosis

    International Nuclear Information System (INIS)

    Sinzinger, H.; Virgolini, I.

    1990-01-01

    Although the pathomechanisms of atherosclerosis are well known, their radioisotopic monitoring is still in its early childhood. The current radioisotope techniques are of only limited value for contributing to the clinical diagnosis of atherosclerosis. The limited reaction time of cellular blood constituents (platelets, monocytes) with the vascular surface at the injury site makes it very difficult to catch the point of injury. Lipoproteins excellently allow receptor imaging, while vascular monitoring is only of scientific interest at present. Labelling and subsequent imaging of components of the coagulation cascade have not succeeded so far, nor have attempts using unspecific labels such as porphyrin, polyclonal IgG and Fc fragments, for example. Preliminary evidence indicates that radioisotopic techniques may be of great benefit in the future in elucidating functional aspects of the disease, while they do not contribute to examining the stage and extent of atherosclerosis. (orig.)

  3. Chronic Intermittent Hypoxia Induces Atherosclerosis

    OpenAIRE

    Savransky, Vladimir; Nanayakkara, Ashika; Li, Jianguo; Bevans, Shannon; Smith, Philip L.; Rodriguez, Annabelle; Polotsky, Vsevolod Y.

    2007-01-01

    Rationale: Obstructive sleep apnea, a condition leading to chronic intermittent hypoxia (CIH), is associated with hyperlipidemia, atherosclerosis, and a high cardiovascular risk. A causal link between obstructive sleep apnea and atherosclerosis has not been established.

  4. What Is Atherosclerosis?

    Science.gov (United States)

    ... builds up in the renal arteries. These arteries supply oxygen-rich blood to your kidneys. Over time, chronic kidney disease causes a slow loss of kidney function. The main function of the kidneys is to remove waste and extra water from the body. Overview The cause of atherosclerosis ...

  5. Alcohol and atherosclerosis

    Directory of Open Access Journals (Sweden)

    DA LUZ PROTASIO L.

    2001-01-01

    Full Text Available Atherosclerosis is manifested as coronary artery disease (CAD, ischemic stroke and peripheral vascular disease. Moderate alcohol consumption has been associated with reduction of CAD complications. Apparently, red wine offers more benefits than any other kind of drinks, probably due to flavonoids. Alcohol alters lipoproteins and the coagulation system. The flavonoids induce vascular relaxation by mechanisms that are both dependent and independent of nitric oxide, inhibits many of the cellular reactions associated with atherosclerosis and inflammation, such as endothelial expression of vascular adhesion molecules and release of cytokines from polymorphonuclear leukocytes. Hypertension is also influenced by the alcohol intake. Thus, heavy alcohol intake is almost always associated with systemic hypertension, and hence shall be avoided. In individuals that ingest excess alcohol, there is higher risk of coronary occlusion, arrhythmias, hepatic cirrhosis, upper gastrointestinal cancers, fetal alcohol syndrome, murders, sex crimes, traffic and industrial accidents, robberies, and psychosis. Alcohol is no treatment for atherosclerosis; but it doesn't need to be prohibited for everyone. Thus moderate amounts of alcohol (1-2 drinks/day, especially red wine, may be allowed for those at risk for atherosclerosis complications.

  6. Interview of Antonio Vergara Fernandez about the First Beam

    CERN Multimedia

    Antonio Vergara Fernandez

    2008-01-01

    Antonio Vergara Fernandez : Engineer of the LHC commissioning Questions asked : 1. What does it take to start up the LHC machine? 2. What's the plan for 1st injection day? 3. How do you feel about this?

  7. Intracranial atherosclerosis: current concepts.

    Science.gov (United States)

    Arenillas, Juan F

    2011-01-01

    The most relevant ideas discussed in this article are described here. Intracranial atherosclerotic disease (ICAD) represents the most common cause of ischemic stroke worldwide. Its importance in whites may have been underestimated. New technical developments, such as high-resolution MRI, allow direct assessment of the intracranial atherosclerotic plaque, which may have a profound impact on ICAD diagnosis and therapy in the near future. Early detection of ICAD may allow therapeutic intervention while the disease is still asymptomatic. The Barcelonès Nord and Maresme Asymptomatic Intracranial Atherosclerosis Study is presented here. The main prognostic factors that characterize the patients who are at a higher risk for ICAD recurrence are classified and discussed. The best treatment for ICAD remains to be established. The Stenting Versus Aggressive Medical Management for Preventing Recurrent Stroke in Intracranial Stenosis Study is currently ongoing to address this crucial issue. These and other topics will be discussed at the Fifth International Intracranial Atherosclerosis Conference (Valladolid, Spain, autumn 2011).

  8. Antonio Canova and the Whatever Body

    Directory of Open Access Journals (Sweden)

    Cora Hatshepsut Gilroy-Ware

    2017-02-01

    Full Text Available This article looks at the persistence of classicizing art in postmodern imagery. Specifically, I posit the art of Antonio Canova as a precursor to contemporary fashion advertising, arguing against the notion that his oeuvre is wholly irrelevant to contemporary culture. I focus on a selection of paintings by Canova, works that, having received scant attention from scholars, are obscure in relation to the artist’s corpus of sculpture. At first glance, these paintings are little more than odd pastiches of 16th century old master works, only with figures marked by a highly refined and conspicuously modern appropriation of ideal beauty. Rather than marginal curiosities or footnotes to his figures in marble, these paintings will be discussed for their distinctive treatment of the female form. I frame the artist as a transitional figure, one whose overturning of moralizing deployments of ideal beauty initiated a new corporeal type that endures in the figure of the fashion model. Returning Canova to the central position he once occupied in the nineteenth century, I incorporate the work of Giorgio Agamben, John Berger and Frederic Jameson. Like Aby Warburg’s 'Mnemosyne Atlas', my argument is largely founded on the eloquence of the images themselves.

  9. Eisenstein contemporain : entretien avec Antonio Somaini

    Directory of Open Access Journals (Sweden)

    Bruno Leites

    2016-04-01

    Full Text Available Entretien avec Antonio Somaini à propos des films, des écrits et des dessins de Sergei Eisenstein. Somaini est actuellement un des plus grands spécialistes de l’œuvre d’Eisenstein. À l’entretien, nous parlons de nombreux sujets : les défis de traduire les ouvrages d’Eisenstein, les phases de sa carrière, le développement de sa pensée, la relation de ses films avec ses écrits, sa pratique du dessin et sa passion pour les dessins de Walt Disney. C’est un long entretien dans laquelle nous parlons aussi des principaux concepts d’Eisenstein, tels que l’extase, le pathos, l’organicité, l’attraction, la régression et la plasmaticité. Somaini nous parle également de la spécificité de son travail et de l’urgence de reprendre Eisenstein. D’un côté, il faut le faire sortir de l’histoire du cinéma exclusivement et l’inclure dans le réseau le plus vaste des arts et de la pensée des années 1920, 1930 et 1940. De l’autre côté, il faut penser son projet comme essentiellement contemporain. Comme Somaini l’a dit, ce que nous pensons beaucoup aujourd’hui, le dispositif cinématographique, le rapport entre le cinéma et l’histoire de l’art, l'influence des images sur l’ensemble de l’expérience humaine, cela a toujours été le problème d’Eisenstein.

  10. Alcohol and atherosclerosis

    Directory of Open Access Journals (Sweden)

    Murilo Foppa

    2001-02-01

    Full Text Available Observational studies have attributed a protective effect to alcohol consumption on the development of atherosclerosis and cardiovascular morbidity and mortality. Alcohol intake in the amount of one to two drinks per day results in an estimated 20-40% reduction in cardiovascular events. An additional protective effect, according to major cohort studies, has been attributed to wine, probably due to antioxidant effects and platelet antiaggregation agents. On the other hand, the influence of different patterns of alcohol consumption and environmental factors may explain a great part of the additional effect of wine. Protection may be mediated by modulation of other risk factors, because alcohol increases HDL-C, produces a biphasic response on blood pressure, and modulates the endothelial function, while it neither increases body weight nor impairs glucose-insulin homeostasis. Alcohol may also have a direct effect on atherogenesis. Despite these favorable effects, the current evidence is not enough to justify prescribing alcohol to prevent cardiovascular disease.

  11. Phytosterols and atherosclerosis

    DEFF Research Database (Denmark)

    Schrøder, Malene

    for decades for their natural ability to reduce cholesterol levels in the blood. In the last decade numerous food products added phytosterol esters have been placed on the market, e.g. yellow fat spread, yoghurt, dressing. The products are being marketed as a natural means for people who want to lower...... or advanced lesion) and quantitatively by stereological methods applied to evaluate the area of the intima and the ratio of intima:media on cross sections from three defined places on the aorta. The biochemical endpoint was the cholesterol content in the inner layer of the entire aorta, which is considered...... than 3% brassicasterol are not accepted on the European market. The aim of the study was to investigate the effect of dietary supplementation of RSO derived sterol, with high content of brassicasterols, and stanol esters on the development of atherosclerosis in cholesterol-fed heterozygous WHHL rabbits...

  12. San Francisco District Laboratory (SAN)

    Data.gov (United States)

    Federal Laboratory Consortium — Program CapabilitiesFood Analysis SAN-DO Laboratory has an expert in elemental analysis who frequently performs field inspections of materials. A recently acquired...

  13. En el entierro de Antonio Ucrós Cuéllar.

    Directory of Open Access Journals (Sweden)

    Zoilo Cuéllar-Montoya

    2005-09-01

    Hoy el destino pone en mis labios el adiós definitivo a quien más que tío, fue un gran amigo, colega y profesor y me corresponde hacerlo a título personal y a nombre de la Academia Nacional de Medicina de Colombia, de la cual fue Antonio, su ilustre Miembro de Número. Quiero pintar con las palabras, para que permanezca en nuestros corazones, la figura señera de Antonio; su sonrisa abierta y franca; su forma de ser, directo, concreto y, ciertamente, incondicional en el afecto y la amistad; fue vertical en sus conceptos éticos e intachable en su vida, tanto en la profesional como en la privada. Se destacó, indiscutiblemente, como brillante profesional de la endocrinología, dentro de la cual fue pionero en la subespecialidad pediátrica. Brilló como docente, pues fue indiscutible maestro de su ciencia, cofundador de la Facultad de Medicina del Colegio Mayor de Nuestra Señora del Rosario, como Miembro de Número que era de la Sociedad de Cirugía de Bogotá y del Cuerpo facultativo del Hospital de San José, Facultad de la cual ocupó la Decanatura. Pero fue, sobre todo, consecuencia lógica de su bonhomía, verdadero honor a su estirpe, un incansable apóstol de su profesión: son incontables los menesterosos de salud para el cuerpo y para el alma que, en el curso de su valiosa vida, en su consultorio particular, en los vetustos pabellones de los hospitales que frecuentó, en su casa de campo o aún en la de Bogotá, recibieron de él una generosa y desinteresada ayuda, material y espiritual...

  14. Antonio Gramsci on intellectual thought – Challenging nursing

    OpenAIRE

    Goodman, B

    2017-01-01

    publisher: Elsevier articletitle: Antonio Gramsci on intellectual thought – Challenging nursing journaltitle: Nurse Education Today articlelink: http://dx.doi.org/10.1016/j.nedt.2017.02.023 content_type: simple-article copyright: © 2017 Elsevier Ltd. All rights reserved.

  15. [The receptor theory of atherosclerosis].

    Science.gov (United States)

    Likhoded, V G; Bondarenko, V M; Gintsburg, A L

    2010-01-01

    Lipopolysaccharides of Gram-negative bacteria can interact with Toll-like receptor 4 (TLR4) and induce atheroma formation. The risk of atherosclerosis is decreased in case of TLR4 mutation. Other bacterial ligands and endogenous ligands of TLRs can also be involved in induction of atherogenesis. The general concept of atherosclerosis pathogentsis is presented. According to this concept atherogenesis can be initiated by some reactions resulting from interaction of exogenous and endogenous microbial ligands with Toll-like receptors.

  16. In Memoriam Antonio Reales Orozco (1917-1997

    Directory of Open Access Journals (Sweden)

    Efraim Otero Ruiz

    1997-12-01

    Full Text Available


    Para la academia Nacional de Medicina, en su ámbito más nacional, constituye motivo de sincera condolencia la desaparición, el pasado 23 de febrero, del Académico de Número Dr. Antonio Reales Orozco. Nacido, criado y educado en Barranquilla, el Dr. Reales Orozco se graduó de médico de la Universidad Nacional en 1944 y desde entonces se orientó por la Psiquiatría, especialidad que ejerció por más de cincuenta años.

    Además de haber ocupado por varios años la dirección de diversos frenocomios de hombres y de mujeres en su ciudad natal, fue fundador, codirector y copropietario de la Clínica Psiquiátrica del Atlántico, institución privada en que durante más de treinta años prestó destacados servicios a toda la región de la costa atlántica.

    Ingresó como Miembro Correspondiente en 1983 con el trabajo “El hombre y las ciencias del comportamiento” para posteriormente, en 1986 ascender a la categoría de Miembro de Número con su trabajo “Estudio de mil casos médico-psiquiátricos” que recibió calurosos elogios del ya desaparecido Académico Profesor José Francisco Socarrás.

    Retirado del ejercicio activo de la profesión se dedicó, a partir de ese año, a investigar temas históricos de trascendental importancia que publicó en dos libros, cuyas presentaciones formales se hicieron en el recinto de la Academia: uno, en 1988, titulado Bolívar frente a los médicos y la medicina, en que hace un profundo análisis psicológico de la desconfianza que sentía el Libertador hacia los médicos y analiza la trayectoria de aquellos galenos ejemplares que lo acompañaron en la última etapa de su vida, cuando viaja de Bogotá hacia la costa del Caribe para ir a morir finalmente en la Quinta de San Pedro Alejandrino.}

    El otro, titulado Santander; fundador del Estado Colombiano trazó, en 24 vigorosos capítulos, que van desde el nacimiento hasta la enfermedad y muerte del General Francisco de

  17. Pietro Antonio Tomasello de Padua : un ingeniero militar véneto en la Sicilia de Carlos V

    Directory of Open Access Journals (Sweden)

    Maurizio Vesco

    2011-01-01

    Full Text Available En 1522 el virrey de Sicilia, Ettore Pignatelli, conde de Monteleone, inició una gran campaña para fortalecer las defensas de las principales ciudades de la costa de Sicilia: Palermo, Trapani, Milazzo, Siracusa y, algunos años más tarde, incluso Messina. El ingeniero real Pietro Antonio Tomasello de Padua, un técnico militar Veneto, pidió renovar el sistema de defensas de la isla, con la introducción por primera vez de bastiones circulares y poligonales en fortalezas y murallas de la ciudad. La obra, desconocida hasta ahora, de este importante ingeniero militar activo en Sicilia desde 1523 hasta 1537, año de su muerte, está siendo reconstruida con una importante documentación de archivo. La investigación destaca líneas de continuidad en la estrategia de guerra de Carlos V, lanzada en Sicilia desde la época del virrey Conde de Monteleone. En consecuencia, se hace necesario revisar este extraordinario carácter general dado por los historiadores de la política militar de Ferrante Gonzaga. También hay que revisar la actualización y la autoría de muchas de las fortificaciones más importantes de Sicilia: el fuerte de San Salvador de Messina, anteriormente atribuido a Antonio Ferramolino de Bérgamo, las fortificaciones de defensa y escarpes del castillo de Milazzo y la torre circular de Castellammare de Palermo (estos últimos fechados en la segunda mitad del siglo XV, todas las obras son de Pietro Antonio Tomasello, realizadas en el segundo cuarto del siglo XVI.In 1522 the Viceroy of Sicily Ettore Pignatelli, Count of Monteleone, started a significant campaign for the strengthening of the outworks of the main cities located along the Sicilian coast: Palermo, Trapani, Milazzo, Siracusa and, after a few years, also Messina. The Royal Engineer Pietro Antonio Tomasello from Padua, a military technician from the Veneto region, was charged with renovating the island’s defensive system and introducing for the first time modern circular

  18. Nanomedicine highlights in atherosclerosis

    International Nuclear Information System (INIS)

    Karagkiozaki, Varvara

    2013-01-01

    Atherosclerosis is a multifactorial disease and many different approaches have been attempted for its accurate diagnosis and treatment. The disease is induced by a low-grade inflammatory process in the vascular wall, leading through a cascade of events to the eventual formation of atheromatous plaque and arterial stenosis. Different types of cells participate in the process making more difficult to recognize the potential cellular targets within the plaques for their effective treatment. The rise of nanomedicine over the last decade has provided new types of drug delivery nanosystems that are able to be delivered to a specific diseased site of the vessel for imaging while simultaneously act as therapeutic agents. In this paper, a review of the recent advances in nanomedicine that has provided novel insights to the disease diagnosis and treatment will be given in line with different nanotechnology-based approaches to advance the cardiovascular stents. The main complications of bare metal stents such as restenosis and of drug-eluting stents which is the late stent thrombosis are analyzed to comprehend the demand for emerging therapeutic strategies based on nanotechnology.

  19. Nanomedicine highlights in atherosclerosis

    Energy Technology Data Exchange (ETDEWEB)

    Karagkiozaki, Varvara, E-mail: vakaragk@physics.auth.gr [Aristotle University of Thessaloniki, Nanomedicine Group, Laboratory for Thin Films-Nanosystems and Nanometrology (LTFN), Physics Department (Greece)

    2013-04-15

    Atherosclerosis is a multifactorial disease and many different approaches have been attempted for its accurate diagnosis and treatment. The disease is induced by a low-grade inflammatory process in the vascular wall, leading through a cascade of events to the eventual formation of atheromatous plaque and arterial stenosis. Different types of cells participate in the process making more difficult to recognize the potential cellular targets within the plaques for their effective treatment. The rise of nanomedicine over the last decade has provided new types of drug delivery nanosystems that are able to be delivered to a specific diseased site of the vessel for imaging while simultaneously act as therapeutic agents. In this paper, a review of the recent advances in nanomedicine that has provided novel insights to the disease diagnosis and treatment will be given in line with different nanotechnology-based approaches to advance the cardiovascular stents. The main complications of bare metal stents such as restenosis and of drug-eluting stents which is the late stent thrombosis are analyzed to comprehend the demand for emerging therapeutic strategies based on nanotechnology.

  20. San Marino.

    Science.gov (United States)

    1985-02-01

    San Marino, an independent republic located in north central Italy, in 1983 had a population of 22,206 growing at an annual rate of .9%. The literacy rate is 97% and the infant mortality rate is 9.6/1000. The terrain is mountainous and the climate is moderate. According to local tradition, San Marino was founded by a Christian stonecutter in the 4th century A.D. as a refuge against religious persecution. Its recorded history began in the 9th century, and it has survived assaults on its independence by the papacy, the Malatesta lords of Rimini, Cesare Borgia, Napoleon, and Mussolini. An 1862 treaty with the newly formed Kingdom of Italy has been periodically renewed and amended. The present government is an alliance between the socialists and communists. San Marino has had its own statutes and governmental institutions since the 11th century. Legislative authority at present is vested in a 60-member unicameral parliament. Executive authority is exercised by the 11-member Congress of State, the members of which head the various administrative departments of the goverment. The posts are divided among the parties which form the coalition government. Judicial authority is partly exercised by Italian magistrates in civil and criminal cases. San Marino's policies are tied to Italy's and political organizations and labor unions active in Italy are also active in San Marino. Since World War II, there has been intense rivalry between 2 political coalitions, the Popular Alliance composed of the Christian Democratic Party and the Independent Social Democratic Party, and the Liberty Committee, coalition of the Communist Party and the Socialist Party. San Marino's gross domestic product was $137 million and its per capita income was $6290 in 1980. The principal economic activities are farming and livestock raising, along with some light manufacturing. Foreign transactions are dominated by tourism. The government derives most of its revenue from the sale of postage stamps to

  1. Antonio Aliprandi, un estucador lombardo en la Valencia de 1700

    Directory of Open Access Journals (Sweden)

    Pablo González Tornel

    2002-01-01

    Full Text Available En torno a 1700 aparecen en Valencia varios artistas extranjeros que residirán en la ciudad varios años dejando en ella un considerable volumen de obras. Uno de ellos, Antonio Aliprandi, se especializará en la factura de revestimientos de estuco para interiores principalmente eclesiásticos. En el presente texto se realiza un recorrido por las obras de Aliprandi en Valencia y se documentan varias de ellas hasta el momento sólo atribuidas a su mano.Around 1700 many foreign artists appear in Valencia where they will stand for several years leaving in our town quite a lot of handcrafts. One among them, Antonio Aliprandi, will specialize himself on recovering many buildings with stucco, mainly in churches. This text makes a journey along Aliprandi's art pieces in Valencia after working on files to find the documents refered to them.

  2. El anhelo metafísico de Antonio Machado

    OpenAIRE

    Carlos Llano Cifuentes

    2013-01-01

    In Antonio Machado's poetry, a dissatisfied agnosticism appears; that is, a kind of agnosticism which wants to quit being such, an agnosticism with metaphysical longings. Machado knows that the absence of trascendence does not offer peacefulness, but tediousness and resignation against the changing reality. Being lacks the plenitude it once had and, in this sense, there exists in Machado a double way to understand reality: longing for what was and confirmation of the present. All this generat...

  3. Marco Antonio Chaer Nascimento a festschrift from theoretical chemistry accounts

    CERN Document Server

    Ornellas, Fernando R

    2014-01-01

    In this Festschrift dedicated to the 65th birthday of Marco Antonio Chaer Nascimento, selected researchers in theoretical chemistry present research highlights on major developments in the field. Originally published in the journal Theoretical Chemistry Accounts, these outstanding contributions are now available in a hardcover print format. This volume will be of benefit in particular to those research groups and libraries that have chosen to have only electronic access to the journal. It also provides valuable content for all researchers in theoretical chemistry.

  4. ANTONIO GAMONEDA: LA CONSTRUCCIÓN DEL OLVIDO

    Directory of Open Access Journals (Sweden)

    Jorge Fernández Gonzalo

    2014-10-01

    Full Text Available Nuestro estudio trata de analizar el concepto de memoria y olvido en la producción poética de Antonio Gamoneda a través de obras como Descripción de la mentira, Lápidas, Libro del frío o Arden las pérdidas, y en relación al período histórico que le tocó vivir al autor.

  5. Manuel Antonio Noriega. Panama kindral liigub vanglast vanglasse / Arko Olesk

    Index Scriptorium Estoniae

    Olesk, Arko, 1981-

    2007-01-01

    Ilmunud ka: Postimees : na russkom jazõke 7. sept. lk. 13. Narkootikumide salakaubaveo, väljapressimise ja rahapesu eest USA vanglas viibiva Panama endise sõjaväejuhi Manuel Antonio Noriega vabanemisest, uuest kohtuteest Prantsusmaal, Panamas tagaselja tehtud kohtuotsusest mõrvade, inimõiguste rikkumise ja korruptsiooni eest. Panama sõjalise diktaatori eluteest, võimulepääsemisest ning USA sõjalisest invasioonist 1989. aastal, mis lõpetas kindrali võimu

  6. A Commander’s Guide for Conducting Integration Operations in the San Antonio Military Health System

    Science.gov (United States)

    1999-02-01

    Conducting Integration Operations 27 Denzin , Norman and Lincoln , Yvonna. (1994). Handbook of Qualitative Research. Sage Publications. Thousand Oaks...the Defense. (1998). “Program Decision Memorandum.” August 18, 1998. Phillips, Donald. (1992). Lincoln on Leadership. Warner Books. New York. 1992

  7. Environmental Assessment of Installation Development at Joint Base San Antonio-Lackland, Texas

    Science.gov (United States)

    2013-02-01

    Sanitary Sewer Lines Upgrades Natural Infrastructure Management Projects • Nil. Medio Creek Erosion Control • NI2. Warrior Week Road- Leon Creek Bridge...Intrastate MSL mean sea level MSW municipal solid waste MWD Military Working Dog NAAQS National Ambient Air Quality Standards NAGPRA Native...2-39  2-25. Proposed Location for Project NI1, Medio Creek Erosion Control

  8. Water quality modelling in the San Antonio River Basin driven by radar rainfall data

    OpenAIRE

    Almoutaz Elhassan; Hongjie Xie; Ahmed A. Al-othman; James Mcclelland; Hatim O. Sharif

    2016-01-01

    Continuous monitoring of stream water quality is needed as it has significant impacts on human and ecological health and well-being. Estimating water quality between sampling dates requires model simulation based on the available geospatial and water quality data for a given watershed. Models such as the Soil and Water Assessment Tool (SWAT) can be used to estimate the missing water quality data. In this study, SWAT was used to estimate water quality at a monitoring station near the outlet of...

  9. AFHRL Conference on Human Appraisal: Proceedings Held at San Antonio, Texas, 19-21 March 1979

    Science.gov (United States)

    1981-06-01

    have branched again into many more specific skills; soldering, writing , hammering, sawing, throwing, arid on and on. These skills and knowledges branch...Berkeley) does--they recommended actually writing critical incidents on the scales, a minimum of two--like the original work with the National League of...asked him "How are you evaluating acceptability in this 128 Wk L7 _ us#m?" And he said to me, "Client satisfaction." I asked him what he ielt , lie said

  10. E3 Success Story - San Antonio E3 Case Study: UEMC “Now Hiring”

    Science.gov (United States)

    exas Manufacturing Assistance Center conducted an E3 assessment as part of the local Lean-Clean-Energy program in October of 2009. Overall, UEMC has reduced demand by approximately 30kw and reduced consumption by over 100,000 kwh/year.

  11. Abstracts of the Annual Meeting of Planetary Geologic Mappers, San Antonio, TX, 2009

    Science.gov (United States)

    Bleamaster, Leslie F., III (Editor); Tanaka, Kenneth L.; Kelley, Michael S.

    2009-01-01

    Topics covered include: Geologic Mapping of the Beta-Atla-Themis (BAT) Region of Venus: A Progress Report; Geologic Map of the Snegurochka Planitia Quadrangle (V-1): Implications for Tectonic and Volcanic History of the North Polar Region of Venus; Preliminary Geological Map of the Fortuna Tessera (V-2) Quadrangle, Venus; Geological Map of the Fredegonde (V-57) Quadrangle, Venus; Geological Mapping of the Lada Terra (V-56) Quadrangle, Venus; Geologic Mapping of V-19; Lunar Geologic Mapping: A Preliminary Map of a Portion of the LQ-10 ("Marius") Quadrangle; Geologic Mapping of the Lunar South Pole, Quadrangle LQ-30: Volcanic History and Stratigraphy of Schr dinger Basin; Geologic Mapping along the Arabia Terra Dichotomy Boundary: Mawrth Vallis and Nili Fossae, Mars; Geologic Mapping Investigations of the Northwest Rim of Hellas Basin, Mars; Geologic Mapping of the Meridiani Region of Mars; Geology of a Portion of the Martian Highlands: MTMs -20002, -20007, -25002 and -25007; Geologic Mapping of Holden Crater and the Uzboi-Ladon-Morava Outflow System; Mapping Tyrrhena Patera and Hesperia Planum, Mars; Geologic Mapping of Athabaca Valles; Geologic Mapping of MTM -30247, -35247 and -40247 Quadrangles, Reull Vallis Region, Mars Topography of the Martian Impact Crater Tooting; Mars Structural and Stratigraphic Mapping along the Coprates Rise; Geology of Libya Montes and the Interbasin Plains of Northern Tyrrhena Terra, Mars: Project Introduction and First Year Work Plan; Geology of the Southern Utopia Planitia Highland-Lowland Boundary Plain: Second Year Results and Third Year Plan; Mars Global Geologic Mapping: About Half Way Done; New Geologic Map of the Scandia Region of Mars; Geologic Mapping of the Medusae Fossae Formation on Mars and the Northern Lowland Plains of Venus; Volcanism on Io: Insights from Global Geologic Mapping; and Planetary Geologic Mapping Handbook - 2009.

  12. Study of Medical Ethics Areas of Concern in the Greater San Antonio Area

    Science.gov (United States)

    2006-06-01

    3 4 5 nosocomial infections 1 2 3 4 5 failure to provide patient education 1 2 3 4 5 failure to appropriately address patterns of substandard care 1 2...Modified Delphi Study 58 94 maternal /fetal issues at threshold of viability 95 end of life clarification to families about having directives 96 lab

  13. PUBLIC-PRIVATE COMPETITIONS: Reasonable Processes Used for San Antonio Engine Depot Maintenance Award

    National Research Council Canada - National Science Library

    1999-01-01

    .... 2469a and other applicable laws and regulations, appropriate consideration was given to factors other than cost, and the award resulted in the lowest total cost to the Department of Defense (DOD) for performance of the work.

  14. Transformation of safety culture on the San Antonio service unit of Union Pacific Railroad

    Science.gov (United States)

    2012-10-31

    The Federal Railroad Administration conducted a pilot demonstration of Clear Signal for Action (CSA), a risk reduction process : that combines peer-to-peer feedback, continuous improvement, and safety leadership development. An independent formative ...

  15. A Qualitative Study of Affordability: Virginia and San Antonio Class Programs

    Science.gov (United States)

    2014-06-04

    under a cost-plus-fixed-fee (CPFF) contract for the electric plant and later added cost-plus-award fee for the construction of the ship (Schank et al...From Defense Acquisition University (DAU, n.d.) ACRONYMS ACWP Actual Cost of Wart PerRm!ed AlJW Authorizecl Urpiced Wak BAG Budge{ A1 Cornple5on

  16. Industry - Military Energy Symposium, held 21-23 October 1980, San Antonio, Texas

    Science.gov (United States)

    1980-10-21

    porning Is that of a professional soldier--as oric who will be m the thick of things i1 this currently tentative international order falls -pAprt. In...But the bubble burst in 1973. In a somewhat politit.lly Lue’trived shtortfoll, tie producing Arab states shut off oil exports--draimiatizing Ituw...missions In 14 dayb during the Arab -Israeli conflict--hauling 13,000 tons of military equipment and supphes to Egypt, Syria and !-aq. t They developed

  17. San Antonio-Espiritu Santo Bay, Texas Four band, 1meter resolution, UltraCam orthoimage

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The NOAA Office for Coastal Management purchased digital Vexcel Ultracam imagery and digital elevation models of the Texas coastline at Espiritu-Santo Bay in 2007....

  18. Engines/Fuels Workshop, 6-8 December 1982, San Antonio, Texas.

    Science.gov (United States)

    1982-01-01

    occupies approximately 40% of cooled diesels of exclusive military design and the under - armor hull volume. Of that, only a use. The second is the range of...be placed largely,or better yet, exelusively under armor *: protection. Thus, the more fuel needed for a , • • ’ v’ v• i given range requirement, the

  19. Environmental Assessment: San Antonio Creek Restoration at Vandenberg Air Force Base, California

    Science.gov (United States)

    2008-09-08

    biological hazards including vegetation (i.e. poison oak and stinging nettle ), animals (i.e. insects , spiders, and snakes), and disease vectors (i.e...acre. Native grasses and herbs such as giant wild rye (Leymus condensatus), and stinging nettle (Urtica dioica) dominate this vegetation type...mud, and unstable ground. Biological hazards such as animals ( insects , spiders, and snakes), and disease vectors (ticks and rodents). 3.6.3

  20. Wild Beginnings: How a San Antonio Initiative Instills the Love of Nature in Young Children

    Science.gov (United States)

    Kharod, Deepti; Arreguín-Anderson, Maria G.

    2015-01-01

    This paper describes an environmental education initiative called Starting out Wild (SoW) designed for toddlers and their caretakers. The program, developed by staff and volunteers of a city parks department, engages children ages 1-3 and their parents and caretakers through outdoor learning experiences. We suggest that environmental education…

  1. Weapons Storage Area Survey of Munitions Storage Igloos at Medina Annex, San Antonio, Texas

    Science.gov (United States)

    2013-11-13

    Attachment 2 Contaminants of Concern 1. General. Early nuclear weapons used polonium -beryllium (Po-Be) initiators to generate neutrons during the... foods . b. Compositions. Figure 2-1 is a histogram of key isotopic mixtures of uranium by mass. The composition for DU is a moderately depleted...200 199 230 210 255 286 Min = 171 6 258 193 243 199 188 196 171 212 190 210 207 223 203 211 214 237 257 Median = 209 A B C D E F G H I J K L M N O P Q

  2. Transducer Workshop (16th) Held in San Antonio, Texas on June 18-20, 1991

    Science.gov (United States)

    1991-06-01

    34 he from 1936-40 he was Instructor in EE at Armour says even of the very first gage which Dat- (now Illinois) Institute of Technology in wyler bonded...wirebonds are draped over a dam separating the sensor from the conformal coat- Compared to the first generation sensor de- ing used for structural...base. (No discussion will prevent flow of the coating onto the sensor. be included on the electrical stability of circuit Draping the sensor lead wires

  3. Randolph AFB, San Antonio, Texas. Revised Uniform Summary of Surface Weather Observations (RUSSWO)

    Science.gov (United States)

    1976-03-19

    S700 62.0 70.9 73t5 74.9 76,1 76.3 76.7 77.0 77.1 77.4 77.6 77.6 7 8.u 78.2 78,5 78.8 >_ 600 62.4 72.0 74.8 76,4 77.8 77.8e9I7 78.9 7 795 7 L; 8o r, n...8 .1a - 5 6 8._5 6 8 . 9 -9 8 ,,8 &196.o8 90 1.3 80,0 61,,U 81.6 e2 2 82.4 R2#7 2.9 82.8 32,9 83oU 83911 3.1 83.-1 83,1 83:21 S700 74.6 $4.8 86,u...93.0 9398 91 .4 94.8 9 4,9_ 9_ 5.5 95.5 95 _59 955I._9 A 95.595595.5 S700 88.2 93,5 94,3 9,.9 95o4 95.5 9L." 96.3 96,3 96.4 96.4! 96,4 96.4 96.4 96,4 96

  4. Workload Trend Analysis for the Military Graduate Medical Education Program in San Antonio

    Science.gov (United States)

    2005-05-25

    determining the number of residents the existing casemix can sustain. Further, the utilization of established residency training program assessment tools...care will be reported and discussed in this report. Measuring the relative proportion of the existing casemix by age group will allow the GME...the individual program directors in balancing unpredictable mission requirements against the appropriate number of residents that the current casemix

  5. A Qualitative Study of Affordability: Virginia and San Antonio Class Programs

    Science.gov (United States)

    2014-06-01

    that actual costs and operational tempos resemble original assumptions is the most uncertain aspect of sustainment costs. Operators must respond to a...SSN 774 through SSN 787; this represents 47% of the total inventory, a typical variation for ships from the acquisition standard of 10%. Even... Goldberg , M., … MacKinnon, M. (1994). The U.S. submarine production base (MR-456-OSD). Santa Monica, CA: RAND. Blickstein, I. United States. Department

  6. Proliferating macrophages prevail in atherosclerosis.

    Science.gov (United States)

    Randolph, Gwendalyn J

    2013-09-01

    Macrophages accumulate in atherosclerotic lesions during the inflammation that is part of atherosclerosis development and progression. A new study in mice indicates that the accumulation of macrophages in atherosclerotic plaques depends on local macrophage proliferation rather than the recruitment of circulating monocytes.

  7. Cineclube Antonio das Mortes and its independent film production

    Directory of Open Access Journals (Sweden)

    Marina da Costa Campos

    2014-07-01

    Full Text Available This article analysis the production of experimental films made by Cineclube Antonio das Mortes (CAM in 1980, in Goiania, Through the term "independent film". This work is an initial study, therefore, it’s intended, first, to discuss the various conceptions given to “independent cinema” in Brazilian cinema history, from the late 1940s until 1980. Then, this work will try to understand how this production of this Cineclube approaches or moves away from the different conceptions that this term has acquired over the decades.

  8. Innate lymphoid cells in atherosclerosis.

    Science.gov (United States)

    Engelbertsen, Daniel; Lichtman, Andrew H

    2017-12-05

    The family of innate lymphoid cells (ILCs) consisting of NK cells, lymphoid tissue inducer cells and the 'helper'-like ILC subsets ILC1, ILC2 and ILC3 have been shown to have important roles in protection against microbes, regulation of inflammatory diseases and involved in allergic reactions. ILC1s produce IFN-γ upon stimulation with IL-12 and IL-18, ILC2s produce IL-5 and IL-13 responding to IL-33 and IL-25 while ILC3s produce IL-17 and IL-22 after stimulation with IL-23 or IL-1. Although few studies have directly investigated the role for ILCs in atherosclerosis, several studies have investigated transcription factors and cytokines shared by ILCs and T helper cells. In this review we summarize our current understanding of the role of ILC in atherosclerosis and discuss future directions. Copyright © 2017. Published by Elsevier B.V.

  9. L'uomo inquieto. Identità e alterità nell'opera di Antonio Tabucchi

    DEFF Research Database (Denmark)

    Lausten, Pia Schwarz

    Italiensk litteratur 1980-2000, Gianni Vattimo, Michail Bachtin, Identitetsproblematik i Antonio Tabucchis forfatterskab, subjektivitetsforståelse......Italiensk litteratur 1980-2000, Gianni Vattimo, Michail Bachtin, Identitetsproblematik i Antonio Tabucchis forfatterskab, subjektivitetsforståelse...

  10. Atherosclerosis in Juvenile Idiopathic Arthritis

    Directory of Open Access Journals (Sweden)

    Ewa Jednacz

    2012-01-01

    Full Text Available Atherosclerosis is a chronic inflammatory disease of the arteries. Clinical consequences of the atherosclerotic process occur in the adult population, however atherosclerotic process begins in childhood. The classic risk factors for atherosclerosis include obesity, dyslipidaemia, age, gender or family history. In recent years, attention has been drawn to the similarity between atherosclerotic inflammatory processes and inflammatory changes in the course of systemic connective tissue disease, in particular systemic lupus etythematosus (SLE or rheumatoid arthritis (RA. There is also observed the similarity of the pathogenetic background of development of atherosclerosis and juvenile idiopathic arthritis (JIA. Elevated levels of pro-inflammatory cytokines are observed in the course of juvenile idiopathic arthritis. Also homocysteine concentrations, which may play a significant role in the development of atherosclerotic lesions, are observed higher in patients with JIA. Some studies revealed higher carotid intima-media thickness (IMT index values in children with JIA. In view of the fact that atherosclerotic process begins as early as in childhood, the introduction of appropriate preventive measures in children is a matter of utmost importance.

  11. Reflections on Michael Hardt and Antonio Negri’s Book “Assembly”

    Directory of Open Access Journals (Sweden)

    Christian Fuchs

    2017-10-01

    Full Text Available This contribution presents reflections on Michael Hardt and Antonio Negri’s book “Assembly” (2017, Oxford: Oxford University Press, ISBN 978-0190677961. Keywords: assembly, Michael Hardt, Antonio Negri, multitude, common, entrepreneurship of the multitude, the new Prince, digital capitalism, digital assemblage, neoliberalism, finance

  12. [Transdisciplinary Approach for Sarcopenia. Sarcopenia and atherosclerosis].

    Science.gov (United States)

    Kohara, Katsuhiko

    2014-10-01

    Risk factors for sarcopenia, including aging, inflammation, oxidative stress, and sedentary life style, are also known as risks for atherosclerosis. Sarcopenia and atherosclerosis relate each other. We found that sarcopenia, especially sarcopenic visceral obesity in male subjects, was associated with higher arterial stiffness and central blood pressure. We also observed that leptin resistance may underlie the link between sarcopenia, sarcopenic obesity and atherosclerosis. In epidemiological studies, it has been demonstrated sarcopenic indices were associated with cardiovascular death. These findings indicate that sarcopenia could be regarded as risk factor for atherosclerosis and cardiovascular events.

  13. Oxyradical Stress, Endocannabinoids, and Atherosclerosis

    Directory of Open Access Journals (Sweden)

    Anberitha T. Matthews

    2015-12-01

    Full Text Available Atherosclerosis is responsible for most cardiovascular disease (CVD and is caused by several factors including hypertension, hypercholesterolemia, and chronic inflammation. Oxidants and electrophiles have roles in the pathophysiology of atherosclerosis and the concentrations of these reactive molecules are an important factor in disease initiation and progression. Overactive NADPH oxidase (Nox produces excess superoxide resulting in oxidized macromolecules, which is an important factor in atherogenesis. Although superoxide and reactive oxygen species (ROS have obvious toxic properties, they also have fundamental roles in signaling pathways that enable cells to adapt to stress. In addition to inflammation and ROS, the endocannabinoid system (eCB is also important in atherogenesis. Linkages have been postulated between the eCB system, Nox, oxidative stress, and atherosclerosis. For instance, CB2 receptor-evoked signaling has been shown to upregulate anti-inflammatory and anti-oxidative pathways, whereas CB1 signaling appears to induce opposite effects. The second messenger lipid molecule diacylglycerol is implicated in the regulation of Nox activity and diacylglycerol lipase β (DAGLβ is a key biosynthetic enzyme in the biosynthesis eCB ligand 2-arachidonylglycerol (2-AG. Furthermore, Nrf2 is a vital transcription factor that protects against the cytotoxic effects of both oxidant and electrophile stress. This review will highlight the role of reactive oxygen species (ROS in intracellular signaling and the impact of deregulated ROS-mediated signaling in atherogenesis. In addition, there is also emerging knowledge that the eCB system has an important role in atherogenesis. We will attempt to integrate oxidative stress and the eCB system into a conceptual framework that provides insights into this pathology.

  14. Proinflammatory Status, Genetics and Atherosclerosis

    Czech Academy of Sciences Publication Activity Database

    Poledne, R.; Lorenzová, A.; Stávek, P.; Valenta, Zdeněk; Hubáček, J.; Suchánek, R.; Piťha, J.

    2009-01-01

    Roč. 58, Suppl. 2 (2009), S111-S118 ISSN 0862-8408 R&D Projects: GA MŠk(CZ) 1M06014 Grant - others:GA MŠk(CZ) 1M0510 Program:1M Institutional research plan: CEZ:AV0Z10300504 Keywords : atherosclerosis * inflammation * C-reactive protein * genetics Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 1.430, year: 2009 http://www.biomed.cas.cz/physiolres/pdf/58%20Suppl%202/58_S111.pdf

  15. El anhelo metafísico de Antonio Machado

    Directory of Open Access Journals (Sweden)

    Carlos Llano Cifuentes

    2013-11-01

    Full Text Available In Antonio Machado's poetry, a dissatisfied agnosticism appears; that is, a kind of agnosticism which wants to quit being such, an agnosticism with metaphysical longings. Machado knows that the absence of trascendence does not offer peacefulness, but tediousness and resignation against the changing reality. Being lacks the plenitude it once had and, in this sense, there exists in Machado a double way to understand reality: longing for what was and confirmation of the present. All this generates a vacuum in the human being, a thirst of trascendence not satisfied and, at the sme time, hope as longing of trascendence which can only be expressed in metaphysics and poetry. Machado's account on trascendence does not exclude immanence. It is found in and from the self, for itself and in other, and even in the absolutely other.

  16. Landscape concept in photography: from Luigi Ghirri to Antonio Ottomanelli

    Directory of Open Access Journals (Sweden)

    Teodora Malavenda

    2014-05-01

    Full Text Available In the 80s of the last century the Italian photography, like other art forms, reflected the political, economic and cultural changes of the Nation. It was the time of a new documentary photography that investigated the transformation of the urban areas. Within this process the landscape was the subject of a new interpretation. In 2013 this process of documentation was worked out again, but in a modern way, by Antonio Ottomanelli. In his project "Collateral Landscape", he took pictures in different cities of the world such as Kabul, Baghdad, Sadr City, Herat, Dokan, New York, Gaza City. Distant places and only apparently different from each other. In fact, all of them have been destroyed by war or, in the case of New York, have been target of a terrorist attack.

  17. Antonio José Ponte: el espacio como texto

    Directory of Open Access Journals (Sweden)

    María Guadalupe Silva

    2014-04-01

    This essay examines Antonio José Ponte’s tale "Un arte de hacer ruinas" (An Art of making ruins from the perspective of its narrative strategies. Considering the general structure of the book, in which this tale holds a central place, the essay inquires into the meanings of the very notion of "center" in Ponte’s literary project. Since the structuration of space, in particular, urban space, which is the first political space, is a matter of permanent reflection in his work, here I offer a reading of the allegorical "engineering" of the tale, establishing relations with other critical texts by Ponte which defies the metaphysics of Cuban nationalism and the centralizing ideology of the Estate.

  18. Miguel Antonio Caro, el Banco Nacional y el Estado

    Directory of Open Access Journals (Sweden)

    Salomón Kalmanovitz

    1999-09-01

    Full Text Available La Regeneración fue el movimiento político y Miguel Antonio Caro el ideólogo que hicieron que Colombia retornara a la matriz institucional centralizada legada por los españoles, en reacción a la dirección liberal y federalista que pretendió orientarla por la senda del desarrollo capitalista, vía su integración al mercado mundial. Esta fue una tendencia continental, de acuerdo con Douglass North, aún en países donde los liberales ganaron las guerras civiles del siglo XIX (North, 134-135. En este ensayo se trata de analizar el pensamiento económico de Caro y más precisamente sus percepciones sobre la banca central, como parte integral de su concepción del Estado que terminaron por imponerse para la Colombia del siglo XX.

  19. Juan Antonio Rubio appointed as Director-General of CIEMAT

    CERN Multimedia

    2004-01-01

    Juan Antonio Rubio, Head of CERN's ETT unit (Education and Technology Transfer) has been appointed by the Spanish Ministry of Education and Science as the Director General of the Research Centre for Energy, Environment and Technology, CIEMAT. Dr Rubio's career began at the Spanish Nuclear Energy Commission where he held the posts of Investigator, Head of the High Energy Group and Head of Nuclear Physics and High Energy Division. Later, he was named Director of the Department of Basic Investigation and Scientific Director of the CIEMAT. In 1987 he joined CERN as Scientific Adviser to the Director General and Group Leader of the Scientific Assessment Group. Up to now, Dr Rubio has been the Head of the ETT unit, as well as Coordinator for Latin America and Commissioner for the 50th Anniversary of the Organization. He was born on 4 June 1944 in Madrid, and holds a Doctorate in Physical Sciences from the Universidad Complutense de Madrid.

  20. Antonio Boggeri. Considerazioni su un protagonista della grafica italiana

    Directory of Open Access Journals (Sweden)

    Camilla Chiappini

    2012-01-01

    Full Text Available Antonio Boggeri is often remembered in the history of graphics only as the Studio Boggeri’s holder. Indeed he is one of the most important figures of Italian advertising graphics and this not for the works he materially made in this field but for his centrality in the Studio he created: in fact he was the unifying element in it among artists of different personality and sensibility.This article does not pretend to explain in a comprehensive manner his importance but it wants to represent a starting point in a research that reconsiders all round Boggeri. Not only, therefore, for his central role in the Studio, but even for his important contribution as a writer and as a photographer, compensating, in part, the lack of works that fully analyze his figure.

  1. Cell cycle and apoptosis genes in atherosclerosis

    NARCIS (Netherlands)

    Boesten, Lianne Simone Mirjam

    2006-01-01

    The work described in this thesis was aimed at identifying the role of cell cycle and apoptosis genes in atherosclerosis. Atherosclerosis is the primary cause of cardiovascular disease, a disorder occurring in the large and medium-sized arteries of the body. Although in the beginning 90s promising

  2. Regulation of T cell responses in atherosclerosis

    NARCIS (Netherlands)

    Puijvelde, Gijsbrecht Henricus Maria van

    2007-01-01

    One of the most important characteristics of atherosclerosis is the chronic inflammatory response in which T cells and NKT cells are very important. In this thesis several methods to modulate the activity of these T and NKT cells in atherosclerosis are described. The induction of regulatory T cells

  3. In-Vivo Assessment of Coronary Atherosclerosis

    NARCIS (Netherlands)

    G.A. Rodriguez-Granillo

    2006-01-01

    textabstractIntravascular ultrasound (IVUS) has emerged as a highly accurate tool for the serial assessment of the natural history of coronary atherosclerosis and to evaluate the effect of different conventional and emerging drug therapies on the progression of atherosclerosis. The

  4. Inflammation and immune system interactions in atherosclerosis

    NARCIS (Netherlands)

    Legein, Bart; Temmerman, Lieve; Biessen, Erik A. L.; Lutgens, Esther

    2013-01-01

    Cardiovascular disease (CVD) is the leading cause of mortality worldwide, accounting for 16.7 million deaths each year. The underlying cause of the majority of CVD is atherosclerosis. In the past, atherosclerosis was considered to be the result of passive lipid accumulation in the vessel wall.

  5. Cytokines in atherosclerosis: an intricate balance

    NARCIS (Netherlands)

    Boshuizen, M.C.S.

    2016-01-01

    Atherosclerosis is the underlying pathology in the majority of clinical manifestations of cardiovascular diseases, which are nowadays the main global cause of mortality. Atherosclerosis is a lipid-driven chronic inflammatory disease of the arterial wall. This inflammatory response, with cytokines as

  6. Coal exploration in the Alto San Jorge area, Cordoba Department. Exploracion de carbones en el Ato San Jorge, Departamento de Cordoba

    Energy Technology Data Exchange (ETDEWEB)

    Ospina, L H; Oquendo, G G [Geominas Ltda, Medellin (Colombia)

    1989-01-01

    A Mining Feasibility Study in the Area of Alto San Jorge, Department of Cordoba, Colombia, was commissioned by CARBOCOL S.A. to the Consortium Geominas-NACI. An area of 800 Ka2 was explored to define surface mining possibilities within two subareas referred to as Alto San Jorge and San Pedro Ure. Rocks of Cretaceous, Tertiary and Quaternary age crop out in the zone. In the subarea Alto San Jorge the principal structure is a syncline with a south-north direction. The San Pedro Ure subarea is formed by undulations with flanks of low dip, the most important being the San Antonio Syncline because it contains the mining block. The geological study of the surface demonstrated the existence of coal in the Oligocene Cienaga de Oro Formation and the Niocene Cerrito Formation, with potential resources of 6.3 billion tons. The subsequent exploration of the subsoil, with 20.618 m of drilling, permitted determination of demonstrated reserves in the order of 2.9 billion tons within two areas. In the sector selected for the mine plan, in the area of San Pedro-Puerto Libertador, 7.791 m of drilling was accomplished to define a demonstrated reserve of 515 million tons of coal down to a depth of 200. The combustible type coal has 5.000 cal/g. Complete mining schedules were developed at the prefeasibility level for two surface mines with productions of 1.5 MMTY and 4 MMTY. 9 figs., 3 tabs., 28 refs.

  7. Atherosclerosis

    Science.gov (United States)

    ... usually doesn't cause symptoms until it severely narrows or totally blocks an artery. Many people don't know they have it until they have a medical emergency. A physical exam, imaging, and other diagnostic tests can tell ...

  8. Nii kauge, kuid nii omane Brasiilia / Antonio Claudio Carvalho ; interv. Reet Varblane

    Index Scriptorium Estoniae

    Carvalho, Antonio Claudio

    2005-01-01

    Vestlus brasiilia kunstniku Antonio Claudio Carvalhoga 15. X, päeval pärast tema näituse avamist Kunstihoone galeriis. Kunstist, kunstnikest, endast, oma loomingust, kunsti tähendusest praeguses Brasiilias jm.

  9. The Progression and Early detection of Subclinical Atherosclerosis (PESA) study

    DEFF Research Database (Denmark)

    Fernández-Ortiz, Antonio; Jiménez-Borreguero, L Jesús; Peñalvo, José L

    2013-01-01

    The presence of subclinical atherosclerosis is a likely predictor of cardiovascular events; however, factors associated with the early stages and progression of atherosclerosis are poorly defined.......The presence of subclinical atherosclerosis is a likely predictor of cardiovascular events; however, factors associated with the early stages and progression of atherosclerosis are poorly defined....

  10. NMR imaging of human atherosclerosis

    International Nuclear Information System (INIS)

    Toussaint, J.F.

    1995-01-01

    Diagnosis and prognosis of atherosclerosis can no longer be evaluated with morphological parameters only. A description of atherosclerotic plaque composition is necessary to study the mechanisms of plaque rupture, which depends on collagenous cap and lipid core thicknesses. NMR, as a biochemical imaging technique, allows visualization of these components using T1 contrast (mobile lipids), T2 contrast (cap vs. core), spin density (calcifications), diffusion imaging, 1H and 13C spectroscopy. Today, these imaging sequences allow to study in vitro the effects of interventional techniques such as angioplasty or atherectomy. Clinical investigations begin, which will attempt to develop in vivo microscopy and test the ability of NMR to predict plaque rupture. (author). 13 refs., 7 figs

  11. Aging, Atherosclerosis, and IGF-1

    Science.gov (United States)

    Higashi, Yusuke; Sukhanov, Sergiy; Anwar, Asif; Shai, Shaw-Yung

    2012-01-01

    Insulin-like growth factor 1 (IGF-1) is an endocrine and autocrine/paracrine growth factor that circulates at high levels in the plasma and is expressed in most cell types. IGF-1 has major effects on development, cell growth and differentiation, and tissue repair. Recent evidence indicates that IGF-1 reduces atherosclerosis burden and improves features of atherosclerotic plaque stability in animal models. Potential mechanisms for this atheroprotective effect include IGF-1–induced reduction in oxidative stress, cell apoptosis, proinflammatory signaling, and endothelial dysfunction. Aging is associated with increased vascular oxidative stress and vascular disease, suggesting that IGF-1 may exert salutary effects on vascular aging processes. In this review, we will provide a comprehensive update on IGF-1's ability to modulate vascular oxidative stress and to limit atherogenesis and the vascular complications of aging. PMID:22491965

  12. Role of parnaparin in atherosclerosis.

    Science.gov (United States)

    Bonomini, Francesca; Taurone, Samanta; Parnigotto, Pierpaolo; Zamai, Loris; Rodella, Luigi F; Artico, Marco; Rezzani, Rita

    2016-12-01

    Atherosclerosis is characterized by a proliferation of vascular smooth muscle cells (VSMCs) and their migration to the intima, which induces thickening of the intima itself, but the mechanism remains poorly understood. Low molecular weight heparin (LMWH) inhibits the proliferation of VSMCs. Previous studies have shown that a LMWH, parnaparin (PNP), acts on the processes of atherogenesis and atheroprogression in experimental animal models. The aim of this study was to investigate the involvement of oxidative stress, inflammation and VSMCs in the regulation of vascular wall homeostasis. We also considered the possibility of restoring vascular pathological changes using PNP treatment. In order to evaluate vascular remodelling in this study we have analysed the morphological changes in aortas of an animal model of atherosclerosis, apolipoprotein E-deficient mice (ApoE-/-) fed with a normal or a western diet without treatment or treated with PNP. We also analysed, by immunohistochemistry, the expression of proteins linked to atherogenesis and atheroprogression - an enzyme involved in oxidative stress, iNOS, examples of inflammatory mediators, such as tumour necrosis factor alpha (TNF-α), interleukins 1 and 6 (IL-1 and IL-6), and markers of VSMC changes, in particular plasminogen activator inhibitor-1 and thrombospondin-1 (PAI-1 and TSP-1). Our results could suggest that PNP downregulates VSMC proliferation and migration, mediated by PAI-1 and TSP-1, and reduces inflammation and oxidative stress in vessels. These data suggested that LMWH, in particular PNP, could be a theoretically practical tool in the prevention of atherosclerotic vascular modification. © 2017 The Authors. International Journal of Experimental Pathology © 2017 International Journal of Experimental Pathology.

  13. Sphingosine 1-Phosphate and Atherosclerosis

    Science.gov (United States)

    Yatomi, Yutaka

    2018-01-01

    Sphingosine 1-phosphate (S1P) is a potent lipid mediator that works on five kinds of S1P receptors located on the cell membrane. In the circulation, S1P is distributed to HDL, followed by albumin. Since S1P and HDL share several bioactivities, S1P is believed to be responsible for the pleiotropic effects of HDL. Plasma S1P levels are reportedly lower in subjects with coronary artery disease, suggesting that S1P might be deeply involved in the pathogenesis of atherosclerosis. In basic experiments, however, S1P appears to possess both pro-atherosclerotic and anti-atherosclerotic properties; for example, S1P possesses anti-apoptosis, anti-inflammation, and vaso-relaxation properties and maintains the barrier function of endothelial cells, while S1P also promotes the egress and activation of lymphocytes and exhibits pro-thrombotic properties. Recently, the mechanism for the biased distribution of S1P on HDL has been elucidated; apolipoprotein M (apoM) carries S1P on HDL. ApoM is also a modulator of S1P, and the metabolism of apoM-containing lipoproteins largely affects the plasma S1P level. Moreover, apoM modulates the biological properties of S1P. S1P bound to albumin exerts both beneficial and harmful effects in the pathogenesis of atherosclerosis, while S1P bound to apoM strengthens anti-atherosclerotic properties and might weaken the pro-atherosclerotic properties of S1P. Although the detailed mechanisms remain to be elucidated, apoM and S1P might be novel targets for the alleviation of atherosclerotic diseases in the future. PMID:28724841

  14. Stent-assisted angioplasty for intracranial atherosclerosis

    International Nuclear Information System (INIS)

    Nakahara, Toshinori; Sakamoto, Shigeyuki; Hamasaki, Osamu; Sakoda, Katsuaki

    2002-01-01

    We report on two patients with intracranial atherosclerosis of the carotid artery or vertebral artery treated with stent-assisted angioplasty. Both patients have severe intracranial atherosclerosis (>70%) with refractory symptoms despite optimal medical treatment. In both patients, a coronary balloon-expandable stent was successfully placed using a protective balloon technique without procedural complications. The patients were asymptomatic and neurologically intact at a mean clinical follow-up of 13 months. Follow-up angiograms did not show restenosis 3 or 4 months after procedure, respectively. Stent-assisted angioplasty for intracranial atherosclerosis in the elective patient has proven effective, with an acceptable low rate of morbidity and mortality. (orig.)

  15. Mito e le visioni musicali di Antonio Buero Vallejo

    Directory of Open Access Journals (Sweden)

    Giada Ferrante

    2012-01-01

    Full Text Available Nel corso della sua attività drammaturgica Antonio Buero Vallejo si confrontò con la scrittura di un unico «libreto para una ópera», intitolato Mito. Il libretto non fu mai musicato, ma venne pubblicato nel 1968 sulle pagine della rivista Primer Acto, preceduto da una breve introduzione dell’autore. Nel 1976, Mito apparve in un’edizione Espasa- Calpe curata da Francisco García Pavón, inseme a La doble historia del Doctor Valmy. Basandosi su quest’ultima pubblicazione, fedele al testo originale, l’articolo indaga la scrittura di Buero, attraverso una sistematica analisi delle didascalie e della costruzione dialogica dell’opera, evidenziando i numerosi suggerimenti musicali del drammaturgo. Dopo una breve introduzione all’opera, si esaminano nel dettaglio gli interventi dell’autore, cercando di rintracciare i diversi ambiti musicali entro cui si muove Buero, per poi arrivare a mostrare la possibile alternanza di un sistema musicale tonale e un sistema musicale dodecafonico. La scrittura musicale sottesa a «Mito» testimonia della spiccata sensibilità del drammaturgo, permettendo di affermare che Buero concepì il testo in forma musicata, fin dalle prime fasi della sua stesura, sostituendosi, in molti casi, all’eventuale compositore, fino a proporre originali e suggestive soluzioni sonore che questo articolo si prefigge di delineare. During his dramatic activity, Antonio Buero Vallejo measured himself with the writing of a single «libreto para una ópera», entitled Mito. This libretto was never set to music, but was published in 1968 in Primer Acto, preceded by a brief introduction of the author. In 1976 Mito appeared in an Espasa-Calpe volume, edited by Francisco García Pavón, together with La doble historia del Doctor Valmy. Based on this edition, true to the original text, the article investigates Buero’s writing through a methodical analysis of the stage directions and the dialogical construction of the text

  16. El último urbanismo de Antonio Bonet: el poblado SOS (1970

    Directory of Open Access Journals (Sweden)

    Juan Fernando Ródenas García

    2018-04-01

    Full Text Available El poblado SOS de Aldeas Infantiles, Sant Feliu de Codines, Barcelona (1970, junto al poblado Hifrensa (realizado y los planes urbanísticos de Prat I y II (no realizados, constituyen los últimos conjuntos urbanísticos de cierto calado proyectados por Antonio Bonet, si exceptuamos su producción turística. Bonet plantea un conjunto residencial para alojar a niños huérfanos con equipamientos comunitarios educacionales y deportivos. Bonet recrea en el poblado SOS la atmósfera, a escala humana, que se respira en aquellos pueblos que aparecen fotografiados en el número 18 (1935 de la revista del GATEPAC, AC Documentos de Actividad Contemporánea, dedicado a la arquitectura popular. Pabellones encalados, bóvedas, porches, patios, muros y plataformas de piedra dispuestas como bancales agrícolas, constituyen los elementos que construyen el paisaje de un poblado de trazo moderno y formas arcaicas. Se propone el análisis de una obra inédita que, aunque no se llevó a cabo, expresa la singular lectura del autor de las condiciones de habitabilidad para niños huérfanos, del paisaje, y al mismo tiempo, la obra condensa la experiencia de Bonet como urbanista ya experimentado que en los años 70 pone a prueba con perspectiva histórica su credo teórico fundamental: la Carta de Atenas.

  17. Social media, publicidad y empresa. Entrevista a Antonio Fumero

    Directory of Open Access Journals (Sweden)

    Ana Mª Belmonte Jiménez

    2012-04-01

    Full Text Available Antonio Fumero es Ingeniero de Telecomunicación y MBA por la Universidad Politécnica de Madrid (UPM. Especialista en la Gestión de la Tecnología e Innovación, trabajó dos años en la Unidad de Desarrollo Tecnológico e Innovación de BBVA como asesor de Nuevas Tecnologías. Actualmente desarrolla su actividad como investigador en la UPM, colaborando con la Cátedra Telefónica para Internet de Nueva Generación y el Departamento de Ingeniería de Sistemas Telemáticos (DIT en la dinamización y coordinación de un grupo de investigadores en Redes y Software Social (iRSS. Desempeña labores de diseminación, asesoría y análisis como experto para distintas organizaciones corporativas e institucionales. Recientemente ha creado su propia empresa, Win Win consultores. También es community manager de Color-Uiris y senior consultant de TalentBrokers.

  18. Maidservant as muse: The dramatic reinvention of Antonio Canova

    Directory of Open Access Journals (Sweden)

    Christina Ferando

    2010-12-01

    Full Text Available In the mid-1870s, the playwright Lodovico Muratori (1834-1919 wrote a play based on the life of the sculptor, Antonio Canova, that focused on a fictional, unconsummated passion between Canova and his housekeeper, Luigia Giuli. This play, published by the Milanese editor Carlo Barbini concurrently with several plays about famous Italian artists, including Michelangelo, Raphael, and Tintoretto, emphasized Canova’s connection to these great masters, in particular his role as both artist and lover. By examining the way political and artistic values changed in Italy over the course of the century, this paper arges that Muratori’s insistent repetition of the trope of ‘Luigia as muse’ is an implicit critique of neoclassicism. Artistic inspiration is disengaged from imitation and the rote act of copying and located instead in the very personal and subjective emotions of the artist. By the late nineteenth century, in order to maintain the validity of an otherwise outmoded style, neoclassicism and its suffocating image of repetition were necessarily recast to fit the political, sociological and artistic developments of the time.

  19. Mouse models for atherosclerosis and pharmaceutical modifiers

    NARCIS (Netherlands)

    Zadelaar, A.S.M.; Kleemann, R.; Verschuren, L.; Vries-van der Weij, J. de; Hoorn, J. van der; Princen, H.M.; Kooistra, T.

    2007-01-01

    Atherosclerosis is a multifactorial highly-complex disease with numerous etiologies that work synergistically to promote lesion development. The ability to develop preventive and ameliorative treatments will depend on animal models that mimic the human subject metabolically and pathophysiologically

  20. A review of Chlamydia pneumoniae and atherosclerosis

    DEFF Research Database (Denmark)

    Lindholt, Jes Sanddal; Fasting, H; Henneberg, E W

    1999-01-01

    Chlamydia pneumoniae is a Gram-negative obligate intracellular bacterium that causes acute upper and lower respiratory infections. Its distribution is worldwide. Seroepidemiological studies have shown an association between C. pneumoniae and atherosclerosis, and the risk of acute myocardial...

  1. Gender-Related Differences in Atherosclerosis

    Czech Academy of Sciences Publication Activity Database

    Mathur, P.; Ošťádal, Bohuslav; Romeo, F.; Mehta, J. L.

    2015-01-01

    Roč. 29, č. 4 (2015), s. 319-327 ISSN 0920-3206 Institutional support: RVO:67985823 Keywords : atherosclerosis * gender Subject RIV: FA - Cardiovascular Diseases incl. Cardiotharic Surgery Impact factor: 3.189, year: 2015

  2. Immune Response to Lipoproteins in Atherosclerosis

    Directory of Open Access Journals (Sweden)

    Sonia Samson

    2012-01-01

    Full Text Available Atherosclerosis, the underlying cause of cardiovascular disease, is characterized by chronic inflammation and altered immune response. Cholesterol is a well-known risk factor associated with the development of cardiovascular diseases. Elevated serum cholesterol is unique because it can lead to development of atherosclerosis in animals and humans even in the absence of other risk factors. Modifications of low-density lipoproteins mediated by oxidation, enzymatic degradation, and aggregation result in changes in their function and activate both innate and adaptive immune system. Oxidized low-density lipoprotein (LDL has been identified as one of the most important autoantigens in atherosclerosis. This escape from self-tolerance is dependent on the formation of oxidized phospholipids. The emerging understanding of the importance of immune responses against oxidized LDL in atherosclerosis has focused attention on the possibility of development of novel therapy for atherosclerosis. This review provides an overview of immune response to lipoproteins and the fascinating possibility of developing an immunomodulatory therapy for atherosclerosis.

  3. Vinpocetine attenuates lipid accumulation and atherosclerosis formation

    International Nuclear Information System (INIS)

    Cai, Yujun; Li, Jian-Dong; Yan, Chen

    2013-01-01

    Highlights: •Vinpocetine attenuates hyperlipidemia-induced atherosclerosis in a mouse model. •Vinpocetine antagonizes ox-LDL uptake and accumulation in macrophages. •Vinpocetine blocks the induction of ox-LDL receptor LOX-1 in vitro and in vivo. -- Abstract: Atherosclerosis, the major cause of myocardial infarction and stroke, is a chronic arterial disease characterized by lipid deposition and inflammation in the vessel wall. Cholesterol, in low-density lipoprotein (LDL), plays a critical role in the pathogenesis of atherosclerosis. Vinpocetine, a derivative of the alkaloid vincamine, has long been used as a cerebral blood flow enhancer for treating cognitive impairment. Recent study indicated that vinpocetine is a potent anti-inflammatory agent. However, its role in the pathogenesis of atherosclerosis remains unexplored. In the present study, we show that vinpocetine significantly reduced atherosclerotic lesion formation in ApoE knockout mice fed with a high-fat diet. In cultured murine macrophage RAW264.7 cells, vinpocetine markedly attenuated oxidized LDL (ox-LDL) uptake and foam cell formation. Moreover, vinpocetine greatly blocked the induction of ox-LDL receptor 1 (LOX-1) in cultured macrophages as well as in the LOX-1 level in atherosclerotic lesions. Taken together, our data reveal a novel role of vinpocetine in reduction of pathogenesis of atherosclerosis, at least partially through suppressing LOX-1 signaling pathway. Given the excellent safety profile of vinpocetine, this study suggests vinpocetine may be a therapeutic candidate for treating atherosclerosis

  4. Oral microbiota in patients with atherosclerosis.

    Science.gov (United States)

    Fåk, Frida; Tremaroli, Valentina; Bergström, Göran; Bäckhed, Fredrik

    2015-12-01

    Recent evidence suggests that the microbiota may be considered as an environmental factor that contributes to the development of atherosclerosis. Periodontal disease has been associated with cardio- and cerebrovascular events, and inflammation in the periodontium is suggested to increase the systemic inflammatory level of the host, which may in turn influence plaque composition and rupture. We previously showed that bacteria from the oral cavity and the gut could be found in atherosclerotic plaques. To elucidate whether the oral microbiota composition differed between patients with asymptomatic and symptomatic atherosclerosis we performed pyrosequencing of the oral microbiota of 92 individuals including patients with asymptomatic and symptomatic atherosclerosis and control individuals without carotid plaques or previous stroke or myocardial infarction. The overall microbial structure was similar in controls and atherosclerosis patients, but patients with symptomatic atherosclerosis had higher relative abundance of Anaeroglobus (mean 0.040% (SD 0.049)) than the control group (0.010% (SD 0.028)) (P = 0.03). Using linear regression analysis, we found that Parvimonas associated positively with uCRP and Capnocytophaga, Catonella and Lactobacillus associated with blood lipid markers. In conclusion, abundance of Anaeroglobus in the oral cavity could be associated with symptomatic atherosclerosis. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  5. Vinpocetine attenuates lipid accumulation and atherosclerosis formation

    Energy Technology Data Exchange (ETDEWEB)

    Cai, Yujun [Aab Cardiovascular Research Institute, Department of Medicine, University of Rochester, 601 Elmwood Ave, Rochester, NY 14642 (United States); Li, Jian-Dong [Center for Inflammation, Immunity and Infection, and Department of Biology, Georgia State University, Atlanta, GA 30303 (United States); Yan, Chen, E-mail: Chen_Yan@urmc.rochester.edu [Aab Cardiovascular Research Institute, Department of Medicine, University of Rochester, 601 Elmwood Ave, Rochester, NY 14642 (United States)

    2013-05-10

    Highlights: •Vinpocetine attenuates hyperlipidemia-induced atherosclerosis in a mouse model. •Vinpocetine antagonizes ox-LDL uptake and accumulation in macrophages. •Vinpocetine blocks the induction of ox-LDL receptor LOX-1 in vitro and in vivo. -- Abstract: Atherosclerosis, the major cause of myocardial infarction and stroke, is a chronic arterial disease characterized by lipid deposition and inflammation in the vessel wall. Cholesterol, in low-density lipoprotein (LDL), plays a critical role in the pathogenesis of atherosclerosis. Vinpocetine, a derivative of the alkaloid vincamine, has long been used as a cerebral blood flow enhancer for treating cognitive impairment. Recent study indicated that vinpocetine is a potent anti-inflammatory agent. However, its role in the pathogenesis of atherosclerosis remains unexplored. In the present study, we show that vinpocetine significantly reduced atherosclerotic lesion formation in ApoE knockout mice fed with a high-fat diet. In cultured murine macrophage RAW264.7 cells, vinpocetine markedly attenuated oxidized LDL (ox-LDL) uptake and foam cell formation. Moreover, vinpocetine greatly blocked the induction of ox-LDL receptor 1 (LOX-1) in cultured macrophages as well as in the LOX-1 level in atherosclerotic lesions. Taken together, our data reveal a novel role of vinpocetine in reduction of pathogenesis of atherosclerosis, at least partially through suppressing LOX-1 signaling pathway. Given the excellent safety profile of vinpocetine, this study suggests vinpocetine may be a therapeutic candidate for treating atherosclerosis.

  6. Carbon monoxide, smoking, and atherosclerosis

    Energy Technology Data Exchange (ETDEWEB)

    Astrup, P

    1973-10-01

    Studies on the effects of carbon monoxide and smoking on atherosclerosis are reviewed. Nonsmokers do not run the risk of getting significantly elevated carboxyhemoglobin levels from automobile exhaust in the streets, however, they do run the risk of getting elevated carboxyhemoglobin levels from exposure to CO in closed areas such as garages and tunnels. Carboxyhemoglobin levels up to 20 percent may also be found in smokers. The central nervous system seems to be influenced by carboxyhemoglobin concentrations up to 20 percent. The myocardium may also be affected. Experimental work with rabbits exposed to carbon monoxide and cholesterol is described which proved that CO has a damaging effect on arterial walls, leading to increased permeability for various plasma components, to the formation of subendothelial edema, and to increased atheromatosis. The results indicate that the much higher risk of smokers of developing arterial disease in comparison to nonsmokers is mainly due to the inhaled CO in the tobacco smoke and not to nicotine. (Air Pollut. Abstr.)

  7. Noninvasive assessment of preclinical atherosclerosis

    Directory of Open Access Journals (Sweden)

    Helen A Lane

    2006-03-01

    Full Text Available Helen A Lane, Jamie C Smith, J Stephen DaviesDepartment of Endocrinology, University of Wales College of Medicine, Heath Park, Cardiff, Wales, UKAbstract: Initially considered as a semipermeable barrier separating lumen from vessel wall, the endothelium is now recognised as a complex endocrine organ responsible for a variety of physiological processes vital for vascular homeostasis. These include the regulation of vascular tone, luminal diameter, and blood flow; hemostasis and thrombolysis; platelet and leucocyte vessel-wall interactions; the regulation of vascular permeability; and tissue growth and remodelling. The endothelium modulates arterial stiffness, which precedes overt atherosclerosis and is an independent predictor of cardiovascular events. Unsurprisingly, dysfunction of the endothelium may be considered as an early and potentially reversible step in the process of atherogenesis and numerous methods have been developed to assess endothelial status and large artery stiffness. Methodology includes flow-mediated dilatation of the brachial artery, assessment of coronary flow reserve, carotid intimamedia thickness, pulse wave analysis, pulse wave velocity, and plethysmography. This review outlines the various modalities, indications, and limitations of available methods to assess arterial dysfunction and vascular risk.Keywords: endothelial function, vascular risk, vascular stiffness

  8. Influence of Erythrocyte Membrane Stability in Atherosclerosis.

    Science.gov (United States)

    da Silva Garrote-Filho, Mario; Bernardino-Neto, Morun; Penha-Silva, Nilson

    2017-04-01

    The purpose of this study is to show how an excess of cholesterol in the erythrocyte membrane contributes stochastically to the progression of atherosclerosis, leading to damage in blood rheology and O 2 transport, deposition of cholesterol (from trapped erythrocytes) in an area of intraplaque hemorrhage, and local exacerbation of oxidative stress. Cholesterol contained in the membrane of erythrocytes trapped in an intraplaque hemorrhage contributes to the growth of the necrotic nucleus. There is even a relationship between the amount of cholesterol in the erythrocyte membrane and the severity of atherosclerosis. In addition, the volume variability among erythrocytes, measured by RDW, is predictive of a worsening of this disease. Erythrocytes contribute to the development of atherosclerosis in several ways, especially when trapped in intraplate hemorrhage. These erythrocytes are oxidized and phagocytosed by macrophages. The cholesterol present in the membrane of these erythrocytes subsequently contributes to the growth of the atheroma plaque. In addition, when they rupture, erythrocytes release hemoglobin, which leads to the generation of free radicals. Finally, increased RDW may predict the worsening of atherosclerosis, due to the effects of inflammation and oxidative stress on erythropoiesis and erythrocyte volume. A better understanding of erythrocyte participation in atherosclerosis may contribute to the improvement of the prevention and treatment strategies of this disease.

  9. Cyanotic congenital heart disease and atherosclerosis.

    Science.gov (United States)

    Tarp, Julie Bjerre; Jensen, Annette Schophuus; Engstrøm, Thomas; Holstein-Rathlou, Niels-Henrik; Søndergaard, Lars

    2017-06-01

    Improved treatment options in paediatric cardiology and congenital heart surgery have resulted in an ageing population of patients with cyanotic congenital heart disease (CCHD). The risk of acquired heart disease such as atherosclerosis increases with age.Previous studies have speculated whether patients with CCHD are protected against atherosclerosis. Results have shown that the coronary arteries of patients with CCHD are free from plaques and stenosis. Decreased carotid intima-media thickness and low total plasma cholesterol may indicate a reduced risk of later development of atherosclerosis. However, the evidence is still sparse and questionable, and a reasonable explanation for the decreased risk of developing atherosclerosis in patients with CCHD is still missing.This review provides an overview of what is known about the prevalence and potential causes of the reduced risk of atherosclerosis in patients with CCHD. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  10. Det 'svage' subjekt. En undersøgelse af det litterære subjekts forandring i Antonio Tabucchis og Gianni Celatis forfatterskaber

    DEFF Research Database (Denmark)

    Lausten, Pia Schwarz

    Italiensk litteratur efter 1980; postmodernisme; subjektsforståelse; Antonio Tabucchi; Gianni Celati; Michail Bachtin; Gianni Vattimo......Italiensk litteratur efter 1980; postmodernisme; subjektsforståelse; Antonio Tabucchi; Gianni Celati; Michail Bachtin; Gianni Vattimo...

  11. ATHEROSCLEROSIS DISEASE: A MULTI-FACTORIAL PATHOLOGY

    Directory of Open Access Journals (Sweden)

    Marcieli da Luz Giroldo1; Arienne Serrano Alves1; Francielle Baptista1

    2007-06-01

    Full Text Available Atherosclerosis or arterial stiffening is a gradual disease that restricts the normal blood flow in different areas of body and maylead to secondary illnesses as myocardial infarction and cerebral stroke. Innumerable factors are related to the development ofatherosclerosis, among them are the dyslipidemia; genetic factors; arterial hypertension; diabetes mellitus; obesity; smoking;lack of exercise; pulmonary infection by Chlamydia and stress. Due to multi-factorial atherosclerosis characteristics,innumerable drugs, with differentiated mechanisms of action, are being elaborated to be used in prevention and control of thisdisease. However, beyond the pharmacological therapy, a balanced diet, physical activity and elimination of risk habits, assmoking, also are need for controlling atherosclerosis progression, as well as for the increase of expectative and quality of life

  12. Osteoprotegerin as a marker of atherosclerosis

    DEFF Research Database (Denmark)

    Hosbond, Susanne Elisabeth; Poulsen, Tina Svenstrup; Diederichsen, Axel Cosmus Pyndt

    2012-01-01

    Abstract Objective: Osteoprotegerin (OPG) may be involved in development of atherosclerosis. To evaluate plasma concentrations of OPG in individuals with stable coronary artery disease (CAD), acute coronary syndrome (ACS), peripheral artery disease (PAD) and cerebrovascular disease (CBVD) a syste......Abstract Objective: Osteoprotegerin (OPG) may be involved in development of atherosclerosis. To evaluate plasma concentrations of OPG in individuals with stable coronary artery disease (CAD), acute coronary syndrome (ACS), peripheral artery disease (PAD) and cerebrovascular disease (CBVD...... with clearly defined cohorts qualified for this review. Results: In 11 studies OPG concentrations were elevated. Severity of atherosclerosis was significantly associated with higher OPG concentrations compared to healthy controls. No association between PAD and OPG concentrations was observed. Conclusion: OPG...

  13. Role of gut microbiota in atherosclerosis

    DEFF Research Database (Denmark)

    Jonsson, Annika Lindskog; Bäckhed, Gert Fredrik

    2017-01-01

    describe three pathways by which microbiota might affect atherogenesis. First, local or distant infections might cause a harmful inflammatory response that aggravates plaque development or triggers plaque rupture. Second, metabolism of cholesterol and lipids by gut microbiota can affect the development...... of atherosclerotic plaques. Third, diet and specific components that are metabolized by gut microbiota can have various effects on atherosclerosis; for example, dietary fibre is beneficial, whereas the bacterial metabolite trimethylamine-N-oxide is considered harmful. Although specific bacterial taxa have been...... associated with atherosclerosis, which is supported by increasing mechanistic evidence, several questions remain to be answered to understand fully how the microbiota contributes to atherosclerosis and cardiovascular disease. Such knowledge might pave the way for novel diagnostics and therapeutics based...

  14. Oral microbiota in patients with atherosclerosis

    DEFF Research Database (Denmark)

    Fåk, Frida; Tremaroli, Valentina; Bergström, Göran

    2015-01-01

    BACKGROUND AND AIMS: Recent evidence suggests that the microbiota may be considered as an environmental factor that contributes to the development of atherosclerosis. Periodontal disease has been associated with cardio- and cerebrovascular events, and inflammation in the periodontium is suggested...... to increase the systemic inflammatory level of the host, which may in turn influence plaque composition and rupture. We previously showed that bacteria from the oral cavity and the gut could be found in atherosclerotic plaques. METHODS: To elucidate whether the oral microbiota composition differed between...... patients with asymptomatic and symptomatic atherosclerosis we performed pyrosequencing of the oral microbiota of 92 individuals including patients with asymptomatic and symptomatic atherosclerosis and control individuals without carotid plaques or previous stroke or myocardial infarction. RESULTS...

  15. Carotid Atherosclerosis and Cognitive Impairment in Nonstroke Patients

    Directory of Open Access Journals (Sweden)

    Wei-Hong Chen

    2017-01-01

    Conclusions: Carotid atherosclerosis can be used to predict the risk of cognitive impairment. Furthermore, diagnosing and treating carotid atherosclerosis at early stage might help clinicians prevent and treat vascular cognitive impairment in nonstroke patients.

  16. Function and Therapeutic Potential of Mesenchymal Stem Cells in Atherosclerosis

    Directory of Open Access Journals (Sweden)

    Feifei Li

    2017-05-01

    Full Text Available Atherosclerosis is a complicated disorder and largely attributable to dyslipidaemia and chronic inflammation. Despite therapeutic advances over past decades, atherosclerosis remains the leading cause of mortality worldwide. Due to their capability of immunomodulation and tissue regeneration, mesenchymal stem cells (MSCs have evolved as an attractive therapeutic agent in various diseases including atherosclerosis. Accumulating evidences support the protective role of MSCs in all stages of atherosclerosis. In this review, we highlight the current understanding of MSCs including their characteristics such as molecular markers, tissue distribution, migratory property, immune-modulatory competence, etc. We also summarize MSC functions in animal models of atherosclerosis. MSC transplantation is able to modulate cytokine and chemokine secretion, reduce endothelial dysfunction, promote regulatory T cell function, decrease dyslipidemia, and stabilize vulnerable plaques during atherosclerosis development. In addition, MSCs may migrate to lesions where they develop into functional cells during atherosclerosis formation. Finally, the perspectives of MSCs in clinical atherosclerosis therapy are discussed.

  17. Technical proposal on the treatment of the influent of the Jose Antonio Alzate dam using aerobic pond system; Propuesta tecnica sobre el tratamiento del influente de la presa Jose Antonio Alzate a traves un sistema lagunar aerobio

    Energy Technology Data Exchange (ETDEWEB)

    Rosas de Alba, S.G. [Instituto Tecnologico de Toluca, Metepec, Estado de Mexico (Mexico)]. E-mail: sergio.rosas01@cfe.gob.mx; Barcelo Quintal, I.D.; Bussy Beaurain, A.L.; lopez Galvan, E. [Universidad Autonoma Metropolitana, Unidad Azcapotzalco (Mexico)]. E-mail: idbq@correo.azc.uam.mx; leemp@correo.azc.uam.mx; loge@correo.azc.uam.mx

    2010-01-15

    In Mexico, discharge of waste water not treated is a common problem; this is the case of the Lerma river, where the original clean water contribution of the Almoloya-Lerma-San Bartolo timber-roof system, located in the valley of Toluca, State of Mexico, was replaced by the wastewater of the valley. The attempts to clean the water before their spill have been unfruitful and this has caused the present anaerobic conditions of the river in its entire route including the first receiving stage that is the Jose Antonio Alzate Dam (PJAA), becoming a potential source of diseases and a useless water body. In this work we evaluate the treatment efficiency of experimental waste water pond system. The treatment system was constructed with 5 screens which formed 6 internal channels and it had an operation in continuous form by 26 weeks, providing it with continuously polluted water of the Lerma river. We found that the efficiency of reduction of the organic matter reported as BOD, was 83% and it is carried out in the first channel after 7 days of hydraulic retention verifying that the channels do not work like lagoons in series. With the collected data we calculated, through the application of design equations, the factor of decay of organic matter k and the number of dispersion d, specific for the type of treatment and environmental conditions of the site. The required surface of treatment calculated to reach the efficiency of reduction of the DOD5 obtained experimentally. Thus, a surface of: 1 281.6 hectares distributed in 13 lagoons that can deal with a volume 8646.70 m{sup 3}/h was determined. Since this was a bigger surface than that of the dam, the available area was evaluated to make a proposal closer to reallity. [Spanish] La descarga de aguas residuales a los sistemas acuaticos, sin previo tratamiento, es un problema generalizado en Mexico; como es el caso del rio Lerma en donde se sustituyo el aporte de agua limpia proveniente del sistema lagunar Almoloya-Lerma-San

  18. Inherited disorders of HDL metabolism and atherosclerosis

    NARCIS (Netherlands)

    Hovingh, G Kees; de Groot, E.P.; van der Steeg, Wim; Boekholdt, S Matthijs; Hutten, Barbara A; Kuivenhoven, J.A.; Kastelein, John J P

    PURPOSE OF REVIEW: Genetic disorders of HDL metabolism are rare and, as a result, the assessment of atherosclerosis risk in individuals suffering from these disorders has been difficult. Ultrasound imaging of carotid arteries has provided a tool to assess the risk in hereditary hypo and

  19. Inherited disorders of HDL metabolism and atherosclerosis

    NARCIS (Netherlands)

    Hovingh, G. Kees; de Groot, Eric; van der Steeg, Wim; Boekholdt, S. Matthijs; Hutten, Barbara A.; Kuivenhoven, Jan Albert; Kastelein, John J. P.

    2005-01-01

    Purpose of review Genetic disorders of HDL metabolism are rare and, as a result, the assessment of atherosclerosis risk in individuals suffering from these disorders has been difficult. Ultrasound imaging of carotid arteries has provided a tool to assess the risk in hereditary hypo and

  20. Metabonomics-based omics study and atherosclerosis

    OpenAIRE

    Wu, Duo-jiao; Zhu, Bi-jun; Wang, Xiang-dong

    2011-01-01

    Atherosclerosis results from dyslipidemia and systemic inflammation, associated with the strong metabolism and interaction between diet and disease. Strategies based on the global profiling of metabolism would be important to define the mechanisms involved in pathological alterations. Metabonomics is the quantitative measurement of the dynamic multiparametric metabolic response of living systems to pathophysiological stimuli or genetic modification. Metabonomics has been used in combination w...

  1. Neutrophils in atherosclerosis. A brief overview

    NARCIS (Netherlands)

    Hartwig, H.; Silvestre Roig, C.; Daemen, M.; Lutgens, E.; Soehnlein, O.

    2015-01-01

    Atherosclerosis is a chronic inflammation of the arterial wall and the continuous infiltration of leukocytes into the plaque enhances the progression of the lesion. Because of the scarce detection of neutrophils in atherosclerotic plaques compared to other immune cells, their contribution was

  2. Effects of apolipoprotein M in uremic atherosclerosis

    DEFF Research Database (Denmark)

    Bosteen, Markus Høybye; Madsen Svarrer, Eva Martha; Bisgaard, Line Stattau

    2017-01-01

    BACKGROUND AND AIMS: Chronic kidney disease is characterized by uremia and causes premature death, partly due to accelerated atherosclerosis. Apolipoprotein (apo) M is a plasma carrier protein for the lipid sphingosine-1-phosphate (S1P). The Apom-S1P complex associates with HDL, and may contribute...

  3. Cyanotic congenital heart disease and atherosclerosis

    DEFF Research Database (Denmark)

    Tarp, Julie Bjerre; Jensen, Annette Schophuus; Engstrøm, Thomas

    2017-01-01

    Improved treatment options in paediatric cardiology and congenital heart surgery have resulted in an ageing population of patients with cyanotic congenital heart disease (CCHD). The risk of acquired heart disease such as atherosclerosis increases with age.Previous studies have speculated whether...

  4. Overview of Atherosclerosis and Chemical Stressors

    Science.gov (United States)

    Dr. Cascio’s presentation at the workshop titled, “titled “Understanding the Combined Effects of Environmental Chemical and Non-Chemical Stressors: Atherosclerosis as a Model” will highlight atherosclerosis’s rapidly growing role as a cause of increa...

  5. Conference Proceedings: Aircraft Gear and Bearing Tribological Systems Held in San Antonio, Texas on 22-26 April 1985.

    Science.gov (United States)

    1986-02-01

    requirements) are presented in Table IT. The selected candidate base oil was a blend of commercially available neopentyl polyol esters. It was selected...engine validation consisted of: 1. a neopentyl polyol ester blend 2. a deposit inhibitor (Ref. 7) 3. a heterocyclic amine oxidation inhibitor 4...lutely required. The use of a glycol or a synthetic hydrocarbon (polyalphaolefin (PAO)l based fluid has been suggested as a possible basestock material for

  6. Identifying agroecological mixed farming strategies for local conditions in San Antonio de Los Baños, Cuba

    NARCIS (Netherlands)

    Monzote, F.R.F.; Bello, R.; Alvarex, A.; Hernández, A.; Lantinga, E.A.; Keulen, van H.

    2012-01-01

    Building on previous research at the experimental and national scales, this study was carried out at the local scale over a four-year period on three farms of reference: one specialized dairy farm ‘Vaquería 10’ (33.7 ha) and two mixed farms, ‘Remedio’ (9.4 ha) and ‘La Sarita’ (47 ha). All three

  7. Proceedings of the Structural Integrity Program Conference. Held in San Antonio, Texas on 29 November-1 December 1988

    Science.gov (United States)

    1989-05-01

    normal wear and tear (brakes, tires, etc.) and extended time between subsystem replacement or repair. - Normal aircraft horizontal takeoff and...T76 Dassault Test Program Inconel 718 2214-T6 Rockwell B-1 B Attachment Links 13-8 PH 7075-T73 International Pratt & Whitney TF-33 Compressor AMS...operational temperature range of 20°F to 100°F lead to the following final damping designs: 625 * 0.004 inch 3M ISD113 and 0.012 inch aluminum

  8. Proceedings of Users’ Stress Workshop (8th) Held San Antonio, Texas on September 24 - 27, 1991

    Science.gov (United States)

    1991-09-01

    children reported lower self esteem and coping than those of older children . With parental absence, the younger children ...soldier during deployment) and having Ogood" children (i.e., ones that don’t stress the remaining parent ). OOS/ S research confirmed the importance of these...benefits and Employee Assistance Programs. They are seen in health-promoting benefits like flex shifts for parents , maternity and paternity leives,

  9. Proceedings of the USAF Structural Integrity Program Conference Held in 11-13 December 1990 in San Antonio, Texas

    Science.gov (United States)

    1991-08-01

    z o wIx 2W WCOZ F-om 0 0 . zu C, 0a <o-z - w c0 -0 CL-cr. a: QI 0~~ Wo I. _ Oo () cr cr. 0< Oz30 i-1*CC0 *lW 0 w a. Cf461 aI~ ɘ w0 WLJW CfOz 0ɘ wwW...in the rotor bore, the sec- ond, a surface crack at the cone- web junction. Typical florescent--penetrate-inspection capability (FPI) is finding a 35 by...this reason, automatic or web , wing ctr. section, stn. eveni computer controlled shot 1000" carry the following peer ing is to be preferred "Repair

  10. Proceedings of the Annual Conference of the Military Testing Association (19th), 17-21 October 1977, San Antonio, Texas

    Science.gov (United States)

    1979-11-01

    to-?ir kills, especially since we will probably be atle to field only a relatively small number of fighter pilots in future wars. Fighter pilots have...Education and Training, Information, And Legal, too many colonel positlons were allocated. Overall, many jobs wer found to be undergraded, especially at the...t preparing the final eppmntice progress/status report, 4e avy C :-vs educacion specialist will regard previous work experience as distri±xtnd

  11. Air Force Personalized Medicine Program Panel: Representative Research at the 59th Medical Wing San Antonio Military Medical Center

    Science.gov (United States)

    2016-05-18

    DNA used to predict individual’s re~nse to cardiac therapeutics &Provide universa l standard sample and ampl icon preparat ion protocol; point of care...coordination of patient evacuation Adverse Childhood Experience Serotonin Transporters and Telomeres: A Gene Environmental Interaction Study of the...Risk of PTSD in Soldiers Biomarkers for Mental Illness and Recovery using Sleep as a Mediator: A Randomized Controlled Trial Characterization of the

  12. Test Review: D. Wechsler "Wechsler Individual Achievement Test-Third Edition." San Antonio, TX--NCS Pearson, 2009

    Science.gov (United States)

    McCrimmon, Adam W.; Climie, Emma A.

    2011-01-01

    This article reviews the "Wechsler Individual Achievement Test-Third Edition" (WIAT-III), a newly updated individual measure of academic achievement for students in Pre-Kindergarten through Grade 12 (age 4 years, 0 months to 19 years, 11 months). Suitable for use in educational, clinical, and research settings, the stated purposes of the WIAT-III…

  13. Test Review: Wechsler, D., & Naglieri, J.A. (2006). "Wechsler Nonverbal Scale of Ability". San Antonio, TX--Harcourt Assessment

    Science.gov (United States)

    Massa, Idalia; Rivera, Vivina

    2009-01-01

    This article provides a review of the Wechsler Nonverbal Scale of Ability (WNV), a general cognitive ability assessment tool for individuals' aged 4 year 0 months through 21 years 11 months with English language and/or communicative limitations. The test targets a population whose performance on intelligence batteries might be compromised by…

  14. Test Review: D. Wechsler "Wechsler Individual Achievement Test" (3rd ed.). San Antonio, Texas--Pearson, 2009

    Science.gov (United States)

    Vaughan-Jensen, Jessica; Adame, Cindy; McLean, Lauren; Gamez, Brenda

    2011-01-01

    This article reviews "Wechsler Individual Achievement Test-Third Edition" (WIAT-III), which is designed to assess students' skills in listening, speaking, reading, writing, and mathematics. The test can identify an individual's strengths and weaknesses, assist professionals who are determining whether a student is eligible for special…

  15. AMEDD Clinical Psychology Short Course Held at Brooke Army Medical Center, San Antonio, Texas, 5-9 June 1991

    Science.gov (United States)

    1991-06-01

    You might find some of the words nasty; you might find some of the words silly. Some of the names I’ve heard are vagina , boo-boo, honey pot or just...what has happened. The mouth, anus and vagina can all be cut open to accommodate a penis, finger, sexual aid, vibrator, or whatever may have been...member of a team rather than isolating oneself because of the myth that one must solve his/her problems alone. Phase III takes three hours and includes

  16. Factores asociados con el proceso de salud y enfermedad en San Antonio (Catamarca, Argentina: un enfoque antropológico

    Directory of Open Access Journals (Sweden)

    Bárbara Martínez

    2016-01-01

    Full Text Available Objetivo: Identificar los procesos de salud y enfermedad entre los pobladores de El Cajón (Catamarca, Argentina y su vinculación con la biomedicina. Asimismo, estudiar las ar - ticulaciones entre la biomedicina y el sistema de salud tradicional. Materiales y métodos: Investigación cualitativa, mediante un abordaje etnográfico en el que la observación participante, la corresidencia y las entrevistas abiertas de sesiones múltiples cumplen un rol primordial. La pesquisa se ha centrado en los pobladores locales que regularmente asisten a la posta sanitaria, los enfermeros, los agentes sanitarios y los miembros del equipo de salud itinerante. La población total del lugar es aproximadamente 235 habitantes. Resultados: Se ha constatado que los procesos de salud y enfermedad no se limitan al cuerpo humano, sino que también en ellos intervienen el paisaje y los seres que lo pueblan. Se ha identificado que en la resolución de numerosas patologías resulta central la figura del especialista ritual. Se ha determinado que la gente valora y utiliza la biomedicina, aunque la asistencia a la institución hospitalaria suele ser rehuida. Conclusiones: Se ha identificado un uso combinado de ambos sistemas. En él influyen las valoraciones de las personas sobre la enfermedad de que se trate, pero también otros factores como la distancia hasta el centro asistencial y las relaciones interpersonales con los profe - sionales de la salud. Se resalta la relevancia del enfoque cualitativo para dar cuenta de las especificidades de las categorías locales, que resultan esquivas para un abordaje construido a partir de conceptos derivados del dualismo cartesiano.

  17. Proceedings of the World Congress on Medical Physics and Biomedical Engineering (San Antonio, Texas, August 6-12, 1988).

    Science.gov (United States)

    Clark, John W., Ed.; And Others

    1988-01-01

    This document contains the proceedings of a joint meeting of the International Federation for Medical and Biological Engineering and the International Organization for Medical Physics. Participants from over 50 countries were in attendance. The theme of the program, "Challenges for the Year 2000," was a reminder of the challenges which confront…

  18. Vector Surveillance to Determine Species Composition and Occurrence of Trypanosoma cruzi Infection at Three Military Installations in San Antonio, Texas

    Science.gov (United States)

    2012-01-01

    the MWD Center have exhibited multiple clinical signs. Canines affected with Chagas disease develop either acute or A B Figure 3. Dog kennel habitat...and dilation . The result is a bilat- eral enlarged heart with fl accid thin walls that exhibit abnormal electrical impulses and arrhythmias on an...electrocardiograph, along with possible respiratory dis- tress. These cases can often be confused with chronic dilative cardiomyopathy observed in other

  19. Relation of water chemistry of the Edwards aquifer to hydrogeology and land use, San Antonio Region, Texas

    Science.gov (United States)

    Buszka, Paul M.

    1987-01-01

    Water-chemistry data from the Edwards aquifer for 1976-85, consisting of nearly 1,500 chemical analyses from 280 wells and 3 springs, were used to statistically evaluate relations among ground-water chemistry, hydrogeology, and land use. Five land uses associated with sampled wells were classified on the basis of published information and field surveys. Four major subareas of the aquifer were defined to reflect the relative susceptibility of ground water to contamination originating from human activities using hydrogeologic and tritium data.

  20. Proceedings of IEEE International Symposium on Information Theory Held in San Antonio, Texas on January 17 - 22, 1993

    Science.gov (United States)

    1993-01-22

    two conistantits. It is note Prlha t if Eq.) 3) is igtiored and Iiii is raiidooi ., t hen thet above Crit erioni is i den t ical to Sbl ravev ’s...to calculate the mean square ’ 21 / Vo (EEP) error caused by source coding mses [1]. Furthermore, .19 ( bpp (EEP)- bpp (UEP)) we need the bit-sensitivity

  1. Use of environmental isotope methods as a reconnaissance tool in groundwater exploration near San Antonio de Pichincha, Ecuador

    International Nuclear Information System (INIS)

    Moser, H.; Stichler, W.

    1975-01-01

    In a semiarid area in the Sierra of Ecuador (about 20 km north of Quito), measurements of deuterium, oxygen 18, and tritium content in spring water, surface water, and precipitation have been performed. The results, together with some meteorological and hydrogeological data, furnished information on the recharge area and on the recharge rate of groundwater. On the basis of the results a groundwater exploitation does not appear feasible. (orig.) [de

  2. Technical Proposal on the Treatment of the Influent of the José Antonio Alzate dam Using Aerobic Pond System

    Directory of Open Access Journals (Sweden)

    E. López–Galván

    2010-01-01

    Full Text Available In México, discharge of waste water not treated is a common problem; this is the case of the Lerma River, where the original clean water contribution of the Almoloya–Lerma–San Bartolo timber–roof system, located in the valley of Toluca, State of México, was replaced by the wastewater of the valley. The attempts to clean the water before their spill have been unfruitful and this has caused the present anaerobic conditions of the river in its entire route including the first receiving stage that is the José Antonio Alzate Dam (PJAA, becoming a potential source of diseases and a useless water body. In this work we evaluate the treatment efficiency of experimental waste water pond system. The treatment system was constructed with 5 screens which formed 6 internal channels and it had an operation in continuous form by 26 weeks, providing it with continuously polluted water of the Lerma River. We found that the efficiency of reduction of the organic matter reported as BOD5 was 83% and it is carried out in the first channel after 7 days of hydraulic retention verifying that the channels do not work like lagoons in series. With the collected data we calculated, through the application of design equations, the factor of decay of organic matter "k" and the number of dispersion "d", specific for the type of treatment and environmental conditions of the site. The required surface of treatment calculated to reach the efficiency of reduction of the BOD5 obtained experimentally. Thus, a surface of: 1 281.6 hectares distributed in 13 lagoons that can deal with a volume 8 646, 70 m3/h was determined. Since this was a bigger surfaces than that of the dam, the available area was evaluated to make a proposal closer to reallity.

  3. Antonio Buero Vallejo y Rodolfo Usigli: Historiografía y dramaturgia

    Directory of Open Access Journals (Sweden)

    Guillermo Schmidhuber de la Mora

    2011-11-01

    Full Text Available The article proposes a comparative analysis of the historical plays written by Mexican Rodolfo Usigli and by Spanish Antonio Buero Vallejo in the critical light of Friedrich Nietzsche and Hayden White, so as to explore the validity of Iberoamerican theatre as historiography. It also examines the relationship between history, metaphor, synecdoche and metonymy in their plays

  4. Reflective Mindreading: Theory of Mind and the Search for Self in Antonio Machado's "Soledades"

    Science.gov (United States)

    Mills, Steven

    2011-01-01

    In Antonio Machado's collection "Soledades", the poet's search for identity guides an introspective quest where context, body, and mind form an intricate and inseparable connection. By extending cognitive capabilities to his natural environment, the poet, through embodied cognition and Theory of Mind, reads other people's and nature's minds to…

  5. Antonio Machado y Ruiz (1875-1939) / koost. ja tlk. Andres Ehin

    Index Scriptorium Estoniae

    2006-01-01

    Hispaania luuletajast Antonio Machadost. Sisaldab ka autori luuletusi "Vanasõnad ja laulud XXIX", "Kas mu süda on uinunud?", "Kõrgmaa laulud", "Tuul, toreda päeva tuul", "Eile öösel nägin und", "Neli luuletust"

  6. Antonio Buero Vallejo y Rodolfo Usigli: Historiografía y dramaturgia

    Directory of Open Access Journals (Sweden)

    Guillermo Schmidhuber de la Mora

    2012-11-01

    Full Text Available The article proposes a comparative analysis of the historical plays written by Mexican Rodolfo Usigli and by Spanish Antonio Buero Vallejo in the critical light of Friedrich Nietzsche and Hayden White, so as to explore the validity of Iberoamerican theatre as historiography. It also examines the relationship between history, metaphor, synecdoche and metonymy in their plays

  7. Rimi juht : Citymarket kaob, hinnad alanevad / Antonio Soares ; interv. Toivo Tänavsuu

    Index Scriptorium Estoniae

    Soares, Antonio

    2005-01-01

    Kesko Foodi ja ICA ühisettevõtte Rimi Balticu juht Antonio Soares ei pea võimalikuks Balti turu väiksuse tõttu Citymarketi kaubamärgi jätmist Eestisse. Citymarketid kujundatakse ümber Rimi Hüpermarketiteks

  8. A la memoria de José Antonio Rojas Tercero, 1959-2008

    Directory of Open Access Journals (Sweden)

    José Miguel Fernández Fernández

    2009-06-01

    Full Text Available La revista recuerda la figura de José Antonio Rojas, Catedrático de Economía Financiera y Contabilidad dde la Universidad de Castilla-La Mancha desde el punto de vista humani y profesional

  9. Antonio Maceo: Agent General of the Provisional Revolutionary Government to the Cuban emigration (I

    Directory of Open Access Journals (Sweden)

    José Antonio Navarro Álvarez

    2009-03-01

    Full Text Available This article describes the role of paramount importance played by Antonio Maceo y Grajales as General Agent of the Provisional Government, one of the less studied and known roles of this preeminent patriot of our wars of independence.

  10. Measuring the Sustainability of Tourism in Manuel Antonio and Texel: a Tourist Perspective

    NARCIS (Netherlands)

    Cottrell, S.P.; Duim, van der V.R.; Ankersmid, P.; Kelder, L.

    2004-01-01

    This paper examines tourist perceptions of sustainability in Manuel Antonio/Quepos, Costa Rica and Texel, The Netherlands. It also reviews tourist opinions of site-specific sustainability aspects and assesses differences between tourist types and their perceptions of sustainability. The ecological

  11. Problematizing the "Taken for Granted" in Educational Issues: Karl Marx, Antonio Gramsci, and Michel Foucault.

    Science.gov (United States)

    Qi, Jie

    This paper explores how educators would raise different questions about educational issues by using Karl Marx's framework, Antonio Gramsci's conception, and Michel Foucault's notions, respectively. First, the paper compares the historical perspectives of Marx and Foucault. Marx concludes that history is a progressive linear production and that…

  12. El Área de Contabilidad de la UCLM y José Antonio Rojas

    Directory of Open Access Journals (Sweden)

    Francisco Javier Quesada Sánchez

    2009-06-01

    Full Text Available Breve historia de los cinco primeros cursos del Área de Contabilidad de la Universidad de Castilla-La Mancha con especial referencia a la dedicación y protagonismo del Profesor José Antonio Rojas Tercero, a quien se rinde homenaje.

  13. San Francisco Accelerator Conference

    International Nuclear Information System (INIS)

    Southworth, Brian

    1991-01-01

    'Where are today's challenges in accelerator physics?' was the theme of the open session at the San Francisco meeting, the largest ever gathering of accelerator physicists and engineers

  14. Coronary atherosclerosis: Significance of autophagic armour.

    Science.gov (United States)

    Arora, Mansi; Kaul, Deepak

    2012-09-26

    Autophagy is a lysosomal degradation pathway of cellular components such as organelles and long-lived proteins. Though a protective role for autophagy has been established in various patho-physiologic conditions such as cancer, neurodegeneration, aging and heart failure, a growing body of evidence now reveals a protective role for autophagy in atherosclerosis, mainly by removing oxidatively damaged organelles and proteins and also by promoting cholesterol egress from the lipid-laden cells. Recent studies by Razani et al and Liao et al unravel novel pathways that might be involved in autophagic protection and in this commentary we highlight the importance of autophagy in atherosclerosis in the light of these two recent papers.

  15. Atherosclerosis and Nanotechnology: Diagnostic and Therapeutic Applications.

    Science.gov (United States)

    Kratz, Jeremy D; Chaddha, Ashish; Bhattacharjee, Somnath; Goonewardena, Sascha N

    2016-02-01

    Over the past several decades, tremendous advances have been made in the understanding, diagnosis, and treatment of coronary artery disease (CAD). However, with shifting demographics and evolving risk factors we now face new challenges that must be met in order to further advance are management of patients with CAD. In parallel with advances in our mechanistic appreciation of CAD and atherosclerosis, nanotechnology approaches have greatly expanded, offering the potential for significant improvements in our diagnostic and therapeutic management of CAD. To realize this potential we must go beyond to recognize new frontiers including knowledge gaps between understanding atherosclerosis to the translation of targeted molecular tools. This review highlights nanotechnology applications for imaging and therapeutic advancements in CAD.

  16. Professor Antonio Branco Lefèvre: the forefather of child neurology in Brazil Professor Antonio Branco Lefèvre o pai da neurologia infantil no Brasil

    Directory of Open Access Journals (Sweden)

    Rubens Reimão

    2008-09-01

    Full Text Available OBJECTIVE: To report on the life and works of Prof. Antonio Branco Lefèvre and the relevance that led him to be considered the Forefather of Child Neurology in Brazil. METHOD: The method utilized was the historical documents research; bibliographical. RESULTS: Antonio Branco Lefèvre (1916-1981 was born in São Paulo city; graduated in 1941 from the São Paulo Medical School. The date - 1950 - can be considered when Child Neurology took shape for a fully specialty, when Lefèvre presented his two internationally acclaimed thesis. Lefèvre was recognized as he founder of Child Neurology in Brazil since the early years of his brilliant academic activities. In 1967 achieved the title of professor in the Child Neurology Clinic. His numerous trainees and Residents - from -1950 to 1981 - held today key positions in Brazilian Child Neurology. CONCLUSION: The extension and importance of the Child Neurology School of which he is the legitimate founder is recognized.OBJETIVO: Relatar a vida e obra do Prof. Antonio Branco Lefèvre e a relevância que leva a ser denominado o Pai da Neurologia Infantil no Brasil. MÉTODO: Pesquisa de documentos históricos e bibliográfica. RESULTADOS: Antonio Branco Lefèvre (1916-1981 nascido em São Paulo; formou-se na Faculdade de Medicina de São Paulo em 1941. A data de 1950 pode ser considerada quando a Neurologia Infantil tornou-se uma especialidade completa quando Lefèvre defendeu suas duas teses aclamadas internacionalmente. Lefévre foi reconhecido como o Pai da Neurologia Infantil no Brasil desde os primeiros anos de sua carreira acadêmica brilhante. Em 1967 atingiu o título de Professor de Neurologia Clínica Infantil. Seus numerosos estagiários e Residentes - de 1950 a 1981 - têm hoje posições de destaque na Neurologia Infantil brasileira. CONCLUSÃO: É reconhecida a extensão e a relevância da escola de Neurologia Infantil da qual Lefèvre é o legítimo fundador.

  17. RENAL INVOLVEMENT IN SUBJECTS WITH PERIPHERAL ATHEROSCLEROSIS

    International Nuclear Information System (INIS)

    FAWZY, A.; IBRAHIM, S.

    2008-01-01

    Ischemic nephropathy is an important cause of renal failure.Sub-clinical renal function abnormalities may exist in patients with extra renal atherosclerosis and may precede the onset of overt ischemic nephropathy. To assess the impact of extrarenal atherosclerosis on the kidney, the study evaluated renal function in 50 subjects with differing degrees of peripheral atherosclerosis without manifest clinical or laboratory signs of ischemic nephropathy and renovascular hypertension.All laboratory testing including total LDL and HDL-cholesterol, triglycerides, ultrasonography with Doppler analysis for the localization of peripheral vascular disease (carotid and lower limb arteries), and non-invasive evaluation of renal function by radionuclide studies of renal plasma flow (MAG3 clearance) and glomerular filtration (DTPA clearance) were determined as well as smoking habit was recorded. By combining sonographic data on arterial tree stenosis (ATS), the subjects were grouped according to the atherosclerotic vascular damage (ATS involvement). The results showed no change in plasma creatinine while DTPA clearance was increased from 91.58±26.53 to 93.47±24.82 ml/min/1.73 m. MAG3 clearance was progressively declined with the severity of vascular damage from 244.86 ± 60.60 to 173.59±58.74 ml/min/1.73 m.Stepwise, multiple regression analysis indicated that MAG3 clearance was best explained by ATS involvement (standardized B coefficient -0.40; P< 0.001), smoking habit (-0.34;P=0.004) and serum LDL-cholesterol (-0.24; P<0.035).It could be concluded that the renal hemodynamic profile in atherosclerotic patients might constitute functional evidence of the silent phase of ischemic renal disease. The findings suggest that renal function should be carefully assessed in patients with extrarenal atherosclerosis, particularly in those with classic cardiovascular risk factors

  18. Cyclodextrin promotes atherosclerosis regression via macrophage reprogramming

    DEFF Research Database (Denmark)

    Zimmer, Sebastian; Grebe, Alena; Bakke, Siril S

    2016-01-01

    -containing lipoproteins in the subendothelial space causes a local overabundance of free cholesterol. Because cholesterol accumulation and deposition of cholesterol crystals (CCs) trigger a complex inflammatory response, we tested the efficacy of the cyclic oligosaccharide 2-hydroxypropyl-β-cyclodextrin (CD), a compound...... of CD as well as for augmented reverse cholesterol transport. Because CD treatment in humans is safe and CD beneficially affects key mechanisms of atherogenesis, it may therefore be used clinically to prevent or treat human atherosclerosis....

  19. Incretin hormones as immunomodulators of atherosclerosis

    Directory of Open Access Journals (Sweden)

    Nuria eAlonso

    2012-09-01

    Full Text Available Atherosclerosis results from endothelial cell dysfunction and inflammatory processes affecting both macro-and microvasculature which are involved in vascular diabetic complications. Glucagon-like peptide 1 (GLP-1 is an incretin hormone responsible for amplification of insulin secretion when nutrients are given orally as opposed to intravenously and it retains its insulinotropic activity in patients with type 2 diabetes mellitus (T2D. GLP-1 based therapies, such as GLP-1 receptor (R agonists and inhibitors of dipeptidyl peptidase 4 (DPP-4, an enzyme that degrades endogenous GLP-1 are routinely used to treat patients with T2D. Recent experimental model studies have established that GLP-1R mRNA is widely expressed in several immune cells. Moreover, its activation contributes to the regulation of both thymocyte and peripheral T cells proliferation and is involved in the maintenance of peripheral regulatory T cells. GLP-1 R is also expressed in endothelial and smooth muscle cells. The effect of incretin hormones on atherosclerogenesis have recently been studied in animal models of apolipoprotein E-deficient mice (apo E-/-. These studies have demonstrated that treatment with incretin hormones or related compounds suppresses the progression of atherosclerosis and macrophage infiltration in the arterial wall as well as a marked anti-oxidative and anti-inflammatory effect on endothelial cells. This effect may have a major impact on the attenuation of atherosclerosis and may help in the design of new therapies for cardiovascular disease in patients with type 2 diabetes.

  20. Atherosclerosis in epilepsy: its causes and implications.

    Science.gov (United States)

    Hamed, Sherifa A

    2014-12-01

    Evidence from epidemiological, longitudinal, prospective, double-blinded clinical trials as well as case reports documents age-accelerated atherosclerosis with increased carotid artery intima media thickness (CA-IMT) in patients with epilepsy. These findings raise concern regarding their implications for age-accelerated cognitive and behavioral changes in midlife and risk of later age-related cognitive disorders including neurodegenerative processes such as Alzheimer's disease (AD). Chronic epilepsy, cerebral atherosclerosis, and age-related cognitive disorders including AD share many clinical manifestations (e.g. characteristic cognitive deficits), risk factors, and structural and pathological brain abnormalities. These shared risk factors include increased CA-IMT, hyperhomocysteinemia (HHcy), lipid abnormalities, weight gain and obesity, insulin resistance (IR), and high levels of inflammatory and oxidative stresses. The resulting brain structural and pathological abnormalities include decreased volume of the hippocampus, increased cortical thinning of the frontal lobe, ventricular expansion and increased white matter ischemic disease, total brain atrophy, and β-amyloid protein deposition in the brain. The knowledge that age-accelerated atherosclerosis may contribute to age-accelerated cognitive and behavioral abnormalities and structural brain pathologies in patients with chronic epilepsy represents an important research path to pursue future clinical and management considerations. Copyright © 2014 Elsevier Inc. All rights reserved.

  1. Pictures to a story. Notes on Vita di San Filippo Neri at the Civic Museum of Bassano del Grappa

    Directory of Open Access Journals (Sweden)

    Federica Vettori

    2014-12-01

    Full Text Available During the eighteenth century the venetian publishing knows a flowering season thanks to the involvement of great artists in the field of illustration. Pietro Antonio Novelli was one of the most prolific inventors of decorations for illustrated books. He sketched the illustrations of Vita di San Filippo Neri engraved by Innocente Alessandri and printed in Venice in 1793. At the Museum of Bassano del Grappa we can find a special watercolored edition: sixty large prints that tell, as if they were history paintings, the life of the saint.

  2. SANS studies of polymers

    International Nuclear Information System (INIS)

    Wignall, G.D.

    1984-10-01

    Before small-angle neutron scattering (SANS), chain conformation studies were limited to light and small angle x-ray scattering techniques, usually in dilute solution. SANS from blends of normal and labeled molecules could give direct information on chain conformation in bulk polymers. Water-soluble polymers may be examined in H 2 O/D 2 O mixtures using contrast variation methods to provide further information on polymer structure. This paper reviews some of the information provided by this technique using examples of experiments performed at the National Center for Small-Angle Scattering Research (NCSASR)

  3. Wastewater characterization of the community 'Antonio Maceo' of the Oriente University

    International Nuclear Information System (INIS)

    Crombet Grillet, Sandra; Perez Pompa, Norma; Abalos Rodriguez, Arelis; Rodriguez Perez, Suyen

    2013-01-01

    The main environmental problems of the Universidad de Oriente are associated with the emission of uncontrolled and untreated solid and liquid waste to the environment. In the university community 'Antonio Maceo' 1 360 people now living, of which 70 % are students of the institution. This community poured about 23 462,7 L/d of wastewater residual liquids composed of 15 buildings and the waters of the kitchen and cafeteria. In this paper we evaluate the physico-chemical and microbiological wastewater university community Antonio Maceo, determining environmental parameters of highest incidence. The waters are neutral and proper salinity. They have gray color, odor and cloudy appearance, without the presence of floating material. The organic matter content is above discharge limits and detected total and fecal coli forms. The greatest variability (46,5 %) of wastewater depends on the turbidity, COD, BOD 5 , sulfide, ammonium, oil and grease and total solids and fixe

  4. Los realismos en Beatus Ille de Antonio Muñoz Molina.

    Directory of Open Access Journals (Sweden)

    Papa Mamour Diop

    2007-07-01

    Full Text Available ENGLISH: This work deals with the current debate about reality and its literary and artistic expression: realism. In Beatus Ille, Antonio Muñoz Molina’s first novel, the fictional universe reveals three kinds of realism: the epic and elegiac realism, the historic realismand the magic realism. SPANISH: En este trabajo, abordamos el actual debate sobre la realidad y su expresión literaria y artística: el realismo. En Beatus Ille, primera novela de Antonio Muñoz Molina, eluniverso novelesco permite percibir tres tipos de realismos: el realismo épico elegiaco, el realismo histórico o contrafactual y el realismo mágico.

  5. Function of CD147 in atherosclerosis and atherothrombosis

    Science.gov (United States)

    Wang, Cuiping; Jin, Rong; Zhu, Xiaolei; Yan, Jinchuan; Guohong, Li

    2015-01-01

    CD147, a member of the immunoglobulin super family, is a well-known potent inducer of extracellular matrix metalloproteinases. Studies show that CD147 is upregulated in inflammatory diseases. Atherosclerosis is a chronic inflammatory disease of the artery wall. Further understanding of the functions of CD147 in atherosclerosis and atherothrombosis may provide a new strategy for preventing and treating cardiovascular disease. In this review, we discuss how CD147 contributes to atherosclerosis and atherothrombosis. PMID:25604960

  6. is-à-vis : Antonio Tabucchi et Fernando Pessoa. Étude de la médiation culturelle dans les fictions biographiques d’Antonio Tabucchi

    Directory of Open Access Journals (Sweden)

    Audrey Lemieux

    2010-12-01

    Full Text Available Comment un écrivain écrit-il à propos d’un autre écrivain – non seulement l’histoire d’une vie, mais la singularité, la vérité particulière d’un homme ? Cet article examine les différentes stratégies par lesquelles l’écrivain-biographe Antonio Tabucchi, dans ses fictions biographiques, parvient à mettre en scène le personnage de Fernando Pessoa, malgré la distance qui les sépare – distance qui semble reposer, à première vue, sur des enjeux culturels, mais qui se révèle être essentiellement ontologique. How does one author undertake writing about another–not only in terms of recounting the story of a life, but also the singularity, the inner truth of a human being? This paper will explore the different strategies by means of which the author/biographer Antonio Tabucchi manages to portray the character of Fernando Pessoa in his biographical fictions, in spite of the distance between them–a distance that initially appears to be rooted in cultural issues, but later reveals itself to be of an essentially ontological order.

  7. Spinoza «protobiologo». Emozioni e sentimenti secondo Antonio Damasio

    Directory of Open Access Journals (Sweden)

    Mariagrazia Portera

    2012-05-01

    Full Text Available My essay reconstructs the broad outline of Antonio Damasio's thought, with particoular reference to his book Looking for Spinoza: Joy, Sorrow and the Feeling Brain (2003, where Damasio describes from a neurobiological point of view human feelings and emotions. In doing that, he highlights how most of the main outcomes of contemporary neurobiological research confirms Spinoza's conception about feelings and emotions (Ethica, 1677.

  8. A reading of Antonio Tabucchi's Il filo dell'orizzonte | Wilson | Italian ...

    African Journals Online (AJOL)

    Questa lettura de Il filo dell'orizzonte (1986) di Antonio Tabucchi esamina il percorso del protagonista, Spino, attraverso gli spazi di una città. La sua è una ricerca ossessiva delle “segrete ragioni” che guidano una vita. Nel tentativo di restituire l'esistenza ad un morto, Spino percepisce che la reciprocità del legame fra vita e ...

  9. Biblioteca gramsciana: os livros da prisão de Antonio Gramsci

    Directory of Open Access Journals (Sweden)

    Lincoln Secco

    2004-06-01

    Full Text Available This article presents preliminary conclusions from research on the books read by Antonio Gramsci in the prison library. Although he had only a few books by Marxist authors at his disposal, Gramsci still was able to face the most important issues of his time. In addition, the article argues that in his Prison Notebooks, Gramsci analyzed these books and their publishers as a means of showing the link between culture and the public.

  10. Antonio Candido de Mello e Souza e Florestan Fernandes: breves perfis

    Directory of Open Access Journals (Sweden)

    Claudinei Carlos Spirandelli

    2010-07-01

    Full Text Available Este artigo enfoca, de maneira didática, perfis e trajetórias de importantes sociólogos paulistas: Antonio Candido de Mello e Souza e Florestan Fernandes. Nosso texto pretende mostrar suas origens, características de obras, os grupos sob suas lideranças e heranças legadas. Neste artigo, pretendemos uma melhor divulgação desses grandes nomes da sociologia brasileira.

  11. (-)-anipamil retards atherosclerosis in Watanabe heritable hyperlipidemic rabbits

    DEFF Research Database (Denmark)

    Hansen, B F; Mortensen, A; Hansen, J F

    1995-01-01

    Calcium antagonists have been reported to limit atherosclerosis in cholesterol fed rabbits. The purpose of this study was to examine the effect of the calcium antagonist (-)-anipamil on the spontaneous development of atherosclerosis in homozygote WHHL rabbits. From the age of 7 weeks, three groups...... differences were found in serum lipids (i.e., VLDL, IDL, LDL, HDL) in the study period among the three groups. Plasma anipamil at the end of the study was 0.23 +/- 6, and 202 +/- 19 ng/ml, respectively, in the three treatment groups. The degree of atherosclerosis in the abdominal aorta was significantly lower...... (p atherosclerosis in the abdominal aorta in WHHL rabbits....

  12. Dom Antonio de Noronha and the secret plan for the Cuieté

    Directory of Open Access Journals (Sweden)

    Laura de Mello e Souza

    2014-01-01

    Full Text Available Filed in the Manuscript Division of the National Library, the work Livro Segundo das Cartas que o Ilmo. e Exmo. Sr. D. Antonio de Noronha Capitão General da Capitania de Minas Gerais escreveu durante o seu governo que teve princípio em 28 de maio de 1776(Second Book of the Letters that His Illustrious Excellency Mr. D. Antonio de Noronha, Captain General of the Captaincy of Minas Gerais, wrote during his government that began on May 28, 1776 is a remarkable set of documents not only about the government of Minas Gerais, but also about important administrative authorities of that period. This Codex includes the Plano secreto para a nova conquista do Cuieté(Secret plan for the new conquest of the Cuieté and the letters to the Marquis of Angeja and the minister Martinho de Mello e Castro, which are herein published. Written by the governor D. Antonio de Noronha himself, the documents show instructions and measures to be taken regarding the Cuieté region, in the sertão (hinterland of Minas Gerais, and reflect on critical issues in the context of the colonization of Portuguese America, such as the exercise of power by part of the metropolitan authorities, the specificity of the colonial population, the settlement of border areas, and the expansion of government and bureaucracy.

  13. Remembering San Diego

    International Nuclear Information System (INIS)

    Chuyanov, V.

    1999-01-01

    After 6 years of existence the ITER EDA project in San Diego, USA, was terminated by desition of the US Congress. This article describes how nice it was for everybody as long as it lasted and how sad it is now

  14. Impact of Prediabetic Status on Coronary Atherosclerosis

    Science.gov (United States)

    Kurihara, Osamu; Takano, Masamichi; Yamamoto, Masanori; Shirakabe, Akihiro; Kimata, Nakahisa; Inami, Toru; Kobayashi, Nobuaki; Munakata, Ryo; Murakami, Daisuke; Inami, Shigenobu; Okamatsu, Kentaro; Ohba, Takayoshi; Ibuki, Chikao; Hata, Noritake; Seino, Yoshihiko; Mizuno, Kyoichi

    2013-01-01

    OBJECTIVE To determine if prediabetes is associated with atherosclerosis of coronary arteries, we evaluated the degree of coronary atherosclerosis in nondiabetic, prediabetic, and diabetic patients by using coronary angioscopy to identify plaque vulnerability based on yellow color intensity. RESEARCH DESIGN AND METHODS Sixty-seven patients with coronary artery disease (CAD) underwent angioscopic observation of multiple main-trunk coronary arteries. According to the American Diabetes Association guidelines, patients were divided into nondiabetic (n = 16), prediabetic (n = 28), and diabetic (n = 23) groups. Plaque color grade was defined as 1 (light yellow), 2 (yellow), or 3 (intense yellow) based on angioscopic findings. The number of yellow plaques (NYPs) per vessel and maximum yellow grade (MYG) were compared among the groups. RESULTS Mean NYP and MYG differed significantly between the groups (P = 0.01 and P = 0.047, respectively). These indexes were higher in prediabetic than in nondiabetic patients (P = 0.02 and P = 0.04, respectively), but similar in prediabetic and diabetic patients (P = 0.44 and P = 0.21, respectively). Diabetes and prediabetes were independent predictors of multiple yellow plaques (NYPs ≥2) in multivariate logistic regression analysis (odds ratio [OR] 10.8 [95% CI 2.09–55.6], P = 0.005; and OR 4.13 [95% CI 1.01–17.0], P = 0.049, respectively). CONCLUSIONS Coronary atherosclerosis and plaque vulnerability were more advanced in prediabetic than in nondiabetic patients and comparable between prediabetic and diabetic patients. Slight or mild disorders in glucose metabolism, such as prediabetes, could be a risk factor for CAD, as is diabetes itself. PMID:23223344

  15. [Evolution of pathogenesis of atherosclerosis in phylogenesis].

    Science.gov (United States)

    Titov, V N

    2014-01-01

    The first atherosclerosis pandemics developed in phylogenesis when animals went out of the ocean, the second coincided with mutations of proteins that transferred zero-cholesterol esters, the third (present-day pandemics) results from disturbed biological function of trophology, abnormally high content of saturated fatty acids and their trans-forms in food, and blockade of bioavailability of polyenic FA (PNFA) for cells. The blood pool of ligand-free lipoproteins, phylogenetically early macrophages are only partly utilized in intima giving rise to atheromatosis. When active absorption of w-3 and w-6 PNFA is blocked, the cells synthesize by way of compensation non-physiological w-9 eicosanoids which creates the basis of pathogenesis of atherosclerosis, pathology ofautocrine regulation, and paracrine humoral regulation of cell communities and the body. A rise in the frequency of non-infectious diseases above 5-7% is regarded as pathology of biological functions and reactions. Non-physiological environmental effects should be neutralized by normalization of tropholgy function, exotrophic biological reaction. Metabolic pandemics may have two outcomes. First: (a) effective reduction to a minimum of infavourable environmental effects, i.e. normalization of the nutritive function, (b) matching it with possibilities of lipoproteins, (c) reduction of morbidity and mortality from atherosclerosis. Second: man continues to develop as in phylogenesis and adapts himself to nonphysiological nutrition. Mortality from infarction and stroke will remain high during the next 40-50 thousand years. Increased content of w-3 PNFA in food without reduction of NAF with blockade of bioavailability will further facilitate atheromatosis. Man should rely on physiological nutrition, there is no reason to rely on hypolipidemic agents. Otherwise, the second outcome awaits the mankind. Tertium non datum.

  16. Probiotics and atherosclerosis – a new challenge?

    Directory of Open Access Journals (Sweden)

    Chan Yee Kwan

    2012-06-01

    Full Text Available Background Atherosclerosis is the major cause of cardiovascular disease and stroke, which are among the top 10 leading causes of death worldwide. Pathogen-associated molecular patterns (PAMPs can activate toll-like receptors (TLRs and activate nuclear factor kappa B (NFκB signaling, a central pathway in inflammation, which regulates genes that encode proinflammatory molecules essential in atherogenesis. Lipopolysaccharides (LPS, which is unique to gram negative bacteria, as well as peptidoglycan (PGN, which is found in gram positive bacteria are PAMPS and ligands of TLR4 and TLR2, respectively, both of which are essential in plaque progression in atherosclerosis. Gastrointestinal tract is suggested to be the major site for absorption and translocation of TLR2 and TLR4 stimulants. Inflammation can result in a ‘leaky gut’ that leads to higher bacterial translocation, eventually the accumulation of LPS and PGN would activate TLRs and trigger inflammation through NFκB and promote further systemic complication like atherosclerosis. Probiotics, can protect the intestinal barrier to reduce bacterial translocation and have potential systemic anti-inflammatory properties.To evaluate whether probiotics can help reduce atherosclerotic development using in vivo study.Apolipoprotein E knockout (ApoE−/ −  mice were fed on high fat diet alone, with telmisartan (Tel (1 or 5 mg/kg/day, positive controls or with probiotics (VSL#3/LGG with or without Tel (1 mg/kg/day for 12 weeks.Probiotics, Tel, or a combination of both reduced lesion size at the aortic root significantly; VSL#3 reduced serum inflammatory adhesion molecules soluble E- (sE-selectin, soluble intercellular adhesion molecule 1 (sICAM-1, soluble vascular cell adhesion molecule 1 (sVCAM-1, and plaque disrupting factor matrix metalloproteinase (MMP-9 significantly; probiotics and Tel at 5 mg/kg/day could induce changes in gut microbiota population; the efficiency of lesion reduction seemed

  17. Apolipoprotein E and carotid artery atherosclerosis - The Rotterdam study

    NARCIS (Netherlands)

    Slooter, AJC; Bots, ML; Havekes, LM; del Sol, AI; Cruts, M; Grobbee, DE; Hofman, A; Van Broeckhoven, C; Witteman, JCM; van Duijn, CM

    Background and Purpose-Carotid artery atherosclerosis is a strong predictor for future stroke. It is yet unclear whether the apolipoprotein E polymorphism (APOE) is related to atherosclerosis in the carotid arteries. The aim of the present study was to investigate the role of APOE in carotid artery

  18. Atherosclerosis: the interplay between lipids and immune cells

    NARCIS (Netherlands)

    Schaftenaar, Frank; Frodermann, Vanessa; Kuiper, Johan; Lutgens, Esther

    2016-01-01

    Cardiovascular disease is the leading cause of mortality worldwide. The underlying cause of the majority of cardiovascular disease is atherosclerosis. In the past, atherosclerosis was considered to be the result of passive lipid accumulation in the vessel wall. However, today's picture of the

  19. Imaging Macrophage and Hematopoietic Progenitor Proliferation in Atherosclerosis

    DEFF Research Database (Denmark)

    Ye, Yu-Xiang; Calcagno, Claudia; Binderup, Tina

    2015-01-01

    tomography-computed tomography imaging of cell proliferation in atherosclerosis. METHODS AND RESULTS: (18)F-FLT positron emission tomography-computed tomography was performed in mice, rabbits, and humans with atherosclerosis. In apolipoprotein E knock out mice, increased (18)F-FLT signal was observed...

  20. Is there an association between coronary atherosclerosis and ...

    African Journals Online (AJOL)

    Background: Atherosclerotic disease is the most common cause of death in the United States and prostate cancer has the highest incidence among males in the United States. Reports have indicated that atherosclerosis and cancers my share common pathoetiologic and pathogenetic cascades. If atherosclerosis and ...

  1. Diet and Atherosclerosis | Grande | South African Medical Journal

    African Journals Online (AJOL)

    Among the various factors affecting the development of atherosclerosis and its complications, the diet emerges as an important influence. This article reviews the evidence linking diet and atherosclerosis; the relation between serum cholesterol concentration and incidence of coronary heart disease, and the effect of various ...

  2. Mechanisms of foam cell formation in atherosclerosis.

    Science.gov (United States)

    Chistiakov, Dimitry A; Melnichenko, Alexandra A; Myasoedova, Veronika A; Grechko, Andrey V; Orekhov, Alexander N

    2017-11-01

    Low-density lipoprotein (LDL) and cholesterol homeostasis in the peripheral blood is maintained by specialized cells, such as macrophages. Macrophages express a variety of scavenger receptors (SR) that interact with lipoproteins, including SR-A1, CD36, and lectin-like oxLDL receptor-1 (LOX-1). These cells also have several cholesterol transporters, including ATP-binding cassette transporter ABCA1, ABCG1, and SR-BI, that are involved in reverse cholesterol transport. Lipids internalized by phagocytosis are transported to late endosomes/lysosomes, where lysosomal acid lipase (LAL) digests cholesteryl esters releasing free cholesterol. Free cholesterol in turn is processed by acetyl-CoA acetyltransferase (ACAT1), an enzyme that transforms cholesterol to cholesteryl esters. The endoplasmic reticulum serves as a depot for maintaining newly synthesized cholesteryl esters that can be processed by neutral cholesterol ester hydrolase (NCEH), which generates free cholesterol that can exit via cholesterol transporters. In atherosclerosis, pro-inflammatory stimuli upregulate expression of scavenger receptors, especially LOX-1, and downregulate expression of cholesterol transporters. ACAT1 is also increased, while NCEH expression is reduced. This results in deposition of free and esterified cholesterol in macrophages and generation of foam cells. Moreover, other cell types, such as endothelial (ECs) and vascular smooth muscle cells (VSMCs), can also become foam cells. In this review, we discuss known pathways of foam cell formation in atherosclerosis.

  3. Periodontitis as a Risk Factor of Atherosclerosis

    Directory of Open Access Journals (Sweden)

    Jirina Bartova

    2014-01-01

    Full Text Available Over the last two decades, the amount of evidence corroborating an association between dental plaque bacteria and coronary diseases that develop as a result of atherosclerosis has increased. These findings have brought a new aspect to the etiology of the disease. There are several mechanisms by which dental plaque bacteria may initiate or worsen atherosclerotic processes: activation of innate immunity, bacteremia related to dental treatment, and direct involvement of mediators activated by dental plaque and involvement of cytokines and heat shock proteins from dental plaque bacteria. There are common predisposing factors which influence both periodontitis and atherosclerosis. Both diseases can be initiated in early childhood, although the first symptoms may not appear until adulthood. The formation of lipid stripes has been reported in 10-year-old children and the increased prevalence of obesity in children and adolescents is a risk factor contributing to lipid stripes development. Endothelium damage caused by the formation of lipid stripes in early childhood may lead to bacteria penetrating into blood circulation after oral cavity procedures for children as well as for patients with aggressive and chronic periodontitis.

  4. Atherosclerosis risk factors in pigeon squabs

    International Nuclear Information System (INIS)

    Klumpp, S.A.; Clarkson, T.B.

    1986-01-01

    The basis for atherosclerosis susceptibility of White Carneau (WC) and resistance of Show Racer (SR) pigeons is not known. Body weight (BW), total serum cholesterol (TSC), growth of the aorta and replication of endothelial cells of the distal thoracic aorta (lesion prone site) of 1, 2 and 4 week old squabs were studied. Aortic measurements were determined morphometrically, and endothelial cell replication was quantitated by 24-hour 3 H-thymidine labeling and whole-mount SEM autoradiography. From hatching to 4 weeks, BW increased more in WC than SR (22 to 473 gm in WC vs 19 to 416 gm in SR, p 2 ) in WC and 44% (101, 140 and 146 mm 2 ) in SR. Aortic surface area was significantly larger (0 = 0.002) in the 4 week WC than 4 week SR. 3 H-thymidine labeled endothelial cells at 1, 2 and 4 weeks were 783, 387 and 53 in WC and 674, 283 and 27 cells/mm 2 in SR. Endothelial replication in the 4 week WC was twice that of the SR and significantly different between breeds at 2 and 4 weeks (p = 0.04; p = 0.02, respectively). Higher TSC, endothelial cell replication and larger aortic surface area in the WC may be contributing factors to increased atherosclerosis susceptibility

  5. Atherosclerosis in Watanabe heritable hyperlipidaemic rabbits. Evaluation by macroscopic, microscopic and biochemical methods and comparison of atherosclerosis variables

    DEFF Research Database (Denmark)

    Hansen, B F; Mortensen, A; Hansen, J F

    1994-01-01

    estimation of aortic atherosclerosis extent and by biochemical analysis of aortic cholesterol content. No noteworthy atherosclerosis was demonstrated within 19 months in heterozygous rabbits. In homozygous rabbits, atherosclerotic lesions were seen from the age of 4 months and progressed with age. All 19......-month-old rabbits had severe atherosclerotic disease. As much as 64% of the variation in atherosclerosis extent/severity could be explained by serum cholesterol and age. A highly significant correlation between the various methods for quantitation of atherosclerosis extent and/or severity...... was demonstrated, suggesting that quantitative microscopy, macroscopic morphometry and determination of aortic cholesterol content may be equally valid as a measure of atherosclerosis in WHHL rabbits and are therefore interchangeable....

  6. Metallothionein and heavy metals in daphnia pulex from Jose Antonio Alzate reservoir

    International Nuclear Information System (INIS)

    Avila Perez, P.; Zarazua Ortega, G.; Barcelo Quintal, D.; Rosas, I.; Diazdelgado, C.

    2001-01-01

    Water and specimens of the freshwater cladoceran Dhapnia pulex were collected at 4 different sites located in an area influenced by industrial, agricultural and urban activities in the Jose Antonio Alzate Reservoir in two different seasons. The Jose Antonio Alzate Reservoir fed by the Lerma river is the first significant water reservoir downstream of the main industrial areas in the State of Mexico. There are about 2,500 industrial discharges between the river source and the Alzate Reservoir which makes the Lerma river and the Jose Antonio Alzate Reservoir the most contaminated water bodies in the State of Mexico. The Monitoring National Network recognises these waters as highly contaminated, especially in the zone located between the Mexico-Toluca highway and the Alzate Reservoir. Water samples and freshwater cladoceran were analysed for Cu and Zn by Energy Dispersive X-Ray Fluorescence (EDXRF) and for Hg and Cd by Neutron Activation Analysis (NAA). As a general feature, the heavy metal concentrations of the water were found to decrease in the sequence: Cu > Zn > Hg > Cd. Metallothioneins (MT) were determined by silver saturation method. Tissue concentrations of MT in Dhapnia pulex varied between 5.69 and 8.96 (mg MT/ g wet wt) in rain season and between 48.87 and 74.00 (mg MT/ g wet wt) in dry season. Metallothioneins levels in Dhapnia pulex were significantly correlated (P < 0.01) with tissue Hg concentrations. In contrast, correlations between MT and tissue levels of Cu and Zn were weak. These observations suggest that Hg2+ activity is the key environmental factor to which metallothionein levels in Daphnia pulex are responding in the studied reservoir

  7. Un oscuro protagonista dell’affaire Moro: Antonio Chichiarelli e il falso comunicato n. 7

    Directory of Open Access Journals (Sweden)

    Francesco Landolfi

    2017-03-01

    Full Text Available The Aldo Moro kidnapping by the Red Brigades was the most dramatic moment of Italian Republic history. The conflict against institutions dragged the nation into a state of impending civil war, resulting in the population mood a daily sense of dread. In this specific episode comes up the criminal picture of Antonio Chichiarelli: Red Brigades fan, neo-fascist, informant, document forger for the Magliana gang and performer of the fake n. 7 announcement. The essay purpose wants to highlight the possible operating links that may have happened between the roman underworld, the Red Brigades and security agencies inside an event still pervaded by several and unsolved issues.

  8. La cuestión de la forma en las sonatas de Antonio Soler

    OpenAIRE

    Igoa Mateos, Enrique

    2014-01-01

    El objetivo de esta tesis doctoral es el estudio de la forma en las 140 sonatas de Antonio Soler (1729-1783). La terminología y las abreviaturas necesarias se exponen en el Cap. 0 (preliminar). El Cap. 1 ofrece una reseña biográfica de Soler, actualizando los datos ya conocidos con las últimas aportaciones bibliográficas. El Cap. 2 se centra en la teoría de la sonata (incorporando las aportaciones de W. Caplin y de Hepokoski & Darcy) y en su asimilación en la música ibérica para tecla d...

  9. Fundamentos de Inteligencia Artificial: Entrevista con Antonio Benítez

    OpenAIRE

    Asier Arias

    2012-01-01

    Antonio Benítez, profesor de Lógica en la Universidad Complutense de Madrid, ha dedicado buena parte de su labor docente e investigadora a la inteligencia artificial y a la filosofía de la mente y de la ciencia cognitiva. Recientemente ha publicado una obra en tres volúmenes titulada Fundamentos de Inteligencia Artificial (el tercer volumen, dedicado a la inteligencia artificial bioinspirada, aparecerá en los próximos meses). La misma ofrece una guía práctica de introducción a la programación...

  10. Situation related to the woman home violence in patients from the "Julio Antonio Mella" polyclinic

    OpenAIRE

    Gil López, Odalys

    2011-01-01

    Introducción: La violencia doméstica hacia la mujer constituye un serio problema de salud, además de una violación flagrante a los derechos humanos, con impacto de la salud biopsicosocial, y afectación a la dinámica familiar. Objetivo: Identificar las características de la violencia doméstica contra las mujeres en el área del policlínico "Julio Antonio Mella", en el 2007. Métodos: Se realizó un estudio descriptivo, longitudinal, retrospectivo, en la población femenina que pertenece al citado ...

  11. Viagem, identidade e memória textual em Antonio Tabucchi

    OpenAIRE

    Melissa Cobra Torre

    2012-01-01

    Esta dissertação apresenta uma reflexão sobre a viagem, a identidade, o jogo e a memória textual na obra de Antonio Tabucchi, tendo em vista o romance 'Noturno Indiano' e os contos 'A frase a seguir é falsa. A frase anterior é verdadeira', 'Il gioco del rovescio', 'Piccoli equivoci senza importanza' e 'I treni che vanno a Madras'. Tem como objetivos repensar o tema da viagem em 'Noturno Indiano'; enfocar a questão da identidade no referido romance; discutir o jogo textual em 'Noturno Indiano'...

  12. Cuerpos invadidos : cuerpo y corporalidad en algunos relatos de Antonio Di Benedetto

    OpenAIRE

    Varela, Fabiana Inés

    2007-01-01

    Mundo Animal (1953) es una colección de cuentos que inicia la carrera literaria del narrador mendocino, Antonio Di Benedetto. Libro de difícil ubicación genérica, tiene una marcada intencionalidad ética que el mismo autor señala de modo explícito. Es además, evidente la filiación kafkianas de muchas de estas historias. Esta relación se observa, especialmente, en el clima fuertemente onírico y opresivo tanto para los personajes como para los lectores, en el escaso interés por la realidad circu...

  13. La cultura en los países no desarrollados: sobre un libro de Antonio Tovar

    Directory of Open Access Journals (Sweden)

    María Mercedes Carranza

    1969-09-01

    Full Text Available El profesor Antonio Tovar es una de las personas más importantes e interesantes de la España contemporánea. Importante en el ámbito científico como investigador, filólogo, traductor de clásicos, ensayista, pedagogo, conocedor en fin de todos los saberes que implican el conocimiento de treinta idiomas y dialectos, desde el indoeuropeo y el sánscrito hasta las lenguas indígenas del Paraná.

  14. Manifestaciones de la subjetividad en ‘Angustia’ (José Antonio Nieves Conde, 1947)

    OpenAIRE

    Higueras Flores, Rubén

    2017-01-01

    En el presente texto pretendemos exponer cómo en el universo cinematográfico del thriller dirigido por José Antonio Nieves Conde se logra hacer copartícipe al espectador de la inquietud y la desazón experimentada por una subjetividad alienada, sirviéndose para ello de precisas estrategias formales que exteriorizan el malestar de unos personajes cercados por una realidad política, social y/o económica que oprime y coacciona al sujeto. La plasmación en el plano formal de la psicología del prota...

  15. José Antonio Portuondo Valdor, Understanding Aesthetic Education from Humanity

    Directory of Open Access Journals (Sweden)

    Kisimira Díaz-Machado

    2016-01-01

    Full Text Available The purpose of the paper is to analyze the specificities in the thought about Aesthetic Education present in Jose Antonio Portuondo. There are exposed elements of the point of view that the Cuban intellectual has about Aesthetic Education from an updated approach, and linked to his idea of building a better society, based on justice and ethic. The research process was conducted through historical-logic and hermeneutic methods. The value of this work lays on it goes deep in the intellectual contribution of Portuondo to the national culture and the Cuban philosophical thought.

  16. Los avatares de la biblioteca privada de Nicolás Antonio (1687-1690

    Directory of Open Access Journals (Sweden)

    Luis ARIAS GONZÁLEZ

    2009-12-01

    Full Text Available Cuando fallece en Madrid Nicolás Antonio, el año de 1684, toda la fortuna que deja a sus herederos, son deudas; deudas a las que fundamentalmente le había llevado el afán investigador y publicista al que dedicó su vida entera. El único bien que le queda a sus deudos, será su colección particular de libros. Precisamente, lo que le sucede a la misma es el tema central de un documento manuscrito, inédito hasta ahora y que se encuentra depositado en la Biblioteca Universitaria Salmantina.

  17. The Historical Archive of the Arcetri Astrophysical Observatory: Antonio and Giorgio Abetti Archive

    Science.gov (United States)

    Gasperini, Antonella; Baglioni, Roberto

    In 1993, during the renovation of the library, we found boxes containing letters, reports, papers, scientific notes, circulars, conference proceedings, astronomical data collections, books, maps, invoices, balance sheets, obituaries, pictures and spectrograms, drawings and journal cuttings. The archival material spanned the years from 1893 to the early 1970s. However, for the time being, only Giorgio Abetti's correspondences are being considered (about 2300 items). In addition, a complete bibliography of Antonio and Giorgio Abetti's publications have been prepared so it is possible to complete the reconstruction of both personalities.

  18. Implications of alcoholic cirrhosis in atherosclerosis of autopsied patients

    Directory of Open Access Journals (Sweden)

    Luciano Alves Matias da Silveira

    Full Text Available Summary Introduction: Alcoholism is a major public health problem, which has a high social cost and affects many aspects of human activity. Liver disease is one of the first consequences of alcohol abuse, and steatosis, liver cirrhosis and hepatitis may occur. Other organs are also affected with pathological changes, such as pancreatitis, cardiomyopathies, dyslipidemias and atherosclerosis. Objective: To identify the occurrence and degree of atherosclerosis in alcohol-dependent individuals with liver cirrhosis, observing macroscopic and microscopic changes in lipid and collagen deposits and in the liver. We also aimed to verify the association of lipid and collagen fiber deposits with gender, age and body mass index, and to relate alcoholism, liver cirrhosis and atherosclerosis. Method: We performed a study based on autopsy reports of patients with alcoholic liver cirrhosis, with analysis of aorta and liver fragments to verify the occurrence and degree of atherosclerosis, as well as collagen contents. Results: Microscopic atherosclerosis was higher in young subjects (early injury and in patients with alcoholic liver cirrhosis. The macroscopic analysis of atherosclerosis in aortas showed that patients in more advanced age groups presented more severe classifications. Atherosclerosis, both micro and macroscopically, and the percentage of fibrosis in the liver and aorta were more expressive in females. Conclusion: Cirrhotic patients presented a higher percentage of fibrosis and lipidosis, and may represent a group susceptible to the accelerated progression of cardiovascular diseases. Investigative studies contribute to targeting health-promoting interventions, reducing the mortality and costs of treating cardiovascular disease.

  19. Correlation between Mitochondrial Reactive Oxygen and Severity of Atherosclerosis

    Directory of Open Access Journals (Sweden)

    Gabriel G. Dorighello

    2016-01-01

    Full Text Available Atherosclerosis has been associated with mitochondria dysfunction and damage. Our group demonstrated previously that hypercholesterolemic mice present increased mitochondrial reactive oxygen (mtROS generation in several tissues and low NADPH/NADP+ ratio. Here, we investigated whether spontaneous atherosclerosis in these mice could be modulated by treatments that replenish or spare mitochondrial NADPH, named citrate supplementation, cholesterol synthesis inhibition, or both treatments simultaneously. Robust statistical analyses in pooled group data were performed in order to explain the variation of atherosclerosis lesion areas as related to the classic atherosclerosis risk factors such as plasma lipids, obesity, and oxidative stress, including liver mtROS. Using three distinct statistical tools (univariate correlation, adjusted correlation, and multiple regression with increasing levels of stringency, we identified a novel significant association and a model that reliably predicts the extent of atherosclerosis due to variations in mtROS. Thus, results show that atherosclerosis lesion area is positively and independently correlated with liver mtROS production rates. Based on these findings, we propose that modulation of mitochondrial redox state influences the atherosclerosis extent.

  20. 75 FR 38412 - Safety Zone; San Diego POPS Fireworks, San Diego, CA

    Science.gov (United States)

    2010-07-02

    ...-AA00 Safety Zone; San Diego POPS Fireworks, San Diego, CA AGENCY: Coast Guard, DHS. ACTION: Temporary... waters of San Diego Bay in support of the San Diego POPS Fireworks. This safety zone is necessary to... San Diego POPS Fireworks, which will include fireworks presentations conducted from a barge in San...

  1. Intranasal immunization with chitosan/pCETP nanoparticles inhibits atherosclerosis in a rabbit model of atherosclerosis.

    Science.gov (United States)

    Yuan, Xiying; Yang, Xiaorong; Cai, Danning; Mao, Dan; Wu, Jie; Zong, Li; Liu, Jingjing

    2008-07-04

    In search of a convenient and pain-free route of administration of DNA vaccine against atherosclerosis, the plasmid pCR-X8-HBc-CETP (pCETP) encoding B-cell epitope of cholesteryl ester transfer protein C-terminal fragment displayed by Hepatitis B virus core particle was condensed with chitosan to form chitosan/pCETP nanoparticles. Cholesterol-fed rabbits were then intranasally immunized with the chitosan/pCETP nanoparticles to evaluate antiatherogenic effects. The results showed that significant serum antibodies against CETP were detected by enzyme-linked immunosorbent analysis and verified by Western blot analysis. The significant anti-CETP IgG lasted for 21 weeks in the rabbits immunized intranasally. Moreover, the atherogenic index was significantly lower compared with the saline control (5.95 versus 2.39, pnanoparticles was 59.2% less than those treated with saline (29.0+/-10.9% versus 71.0+/-14.4%, pintramuscularly injected with pCETP solution (29.0+/-10.9% versus 21.2+/-14.2%, p>0.05). Thus, chitosan/pCETP nanoparticles could significantly attenuate the progression of atherosclerosis by intranasal immunization. The results suggested that intranasal administration could be potentially developed as a vaccination route against atherosclerosis.

  2. Connective tissue diseases and noninvasive evaluation of atherosclerosis

    Directory of Open Access Journals (Sweden)

    Ardita G

    2014-06-01

    Full Text Available Giorgio Ardita, Giacomo Failla, Paolo Maria Finocchiaro, Francesco Mugno, Luigi Attanasio, Salvatore Timineri, Michelangelo Maria Di SalvoCardiovascular Department, Angiology Unit, Ferrarotto Hospital, Catania, ItalyAbstract: Connective tissue diseases (CTDs are associated with increased risk of cardiovascular disease due to accelerated atherosclerosis. In patients with autoimmune disorders, in addition to traditional risk factors, an immune-mediated inflammatory process of the vasculature seems to contribute to atherogenesis. Several pathogenetic mechanisms have been proposed, including chronic inflammation and immunologic abnormalities, both able to produce vascular damage. Macrovascular atherosclerosis can be noninvasively evaluated by ultrasound measurement of carotid or femoral plaque. Subclinical atherosclerosis can be evaluated by well-established noninvasive techniques which rely on ultrasound detection of carotid intima-media thickness. Flow-mediated vasodilatation and arterial stiffness are considered markers of endothelial dysfunction and subclinical atherosclerosis, respectively, and have been recently found to be impaired early in a wide spectrum of autoimmune diseases. Carotid intima-media thickness turns out to be a leading marker of subclinical atherosclerosis, and many studies recognize its role as a predictor of future vascular events, both in non-CTD individuals and in CTD patients. In rheumatic diseases, flow-mediated dilatation and arterial stiffness prove to be strongly correlated with inflammation, disease damage index, and with subclinical atherosclerosis, although their prognostic role has not yet been conclusively shown. Systemic lupus erythematosus, rheumatoid arthritis, and likely antiphospholipid syndrome are better associated with premature and accelerated atherosclerosis. Inconclusive results were reported in systemic sclerosis.Keywords: rheumatic disease, subclinical atherosclerosis, arterial stiffness

  3. Nutraceuticals as therapeutic agents for atherosclerosis.

    Science.gov (United States)

    Moss, Joe W E; Williams, Jessica O; Ramji, Dipak P

    2018-05-01

    Atherosclerosis, a chronic inflammatory disorder of medium and large arteries and an underlying cause of cardiovascular disease (CVD), is responsible for a third of all global deaths. Current treatments for CVD, such as optimized statin therapy, are associated with considerable residual risk and several side effects in some patients. The outcome of research on the identification of alternative pharmaceutical agents for the treatment of CVD has been relatively disappointing with many promising leads failing at the clinical level. Nutraceuticals, products from food sources with health benefits beyond their nutritional value, represent promising agents in the prevention of CVD or as an add-on therapy with current treatments. This review will highlight the potential of several nutraceuticals, including polyunsaturated fatty acids, flavonoids and other polyphenols, as anti-CVD therapies based on clinical and pre-clinical mechanism-based studies. Copyright © 2018 The Author(s). Published by Elsevier B.V. All rights reserved.

  4. Nanotechnology, a new paradigm in atherosclerosis treatment.

    Science.gov (United States)

    Martín Giménez, Virna M; Ruiz-Roso, María Belén; Camargo, Alejandra Beatriz; Kassuha, Diego; Manucha, Walter

    Atherosclerosis, a known and prevalent disease, causes progressive deterioration of affected vessels, inducing a blood flow reduction with different complications, and its symptoms usually manifest in advanced stages of the disease. Therefore, the classic therapeutic alternatives are insufficient because the damages are many times irreversible. For this reason, there is a need to implement intelligent forms of drug administration and develop new therapeutic targets that reduce the progression of atherosclerotic lesion. The implementation of new tools for prevention, diagnosis and treatment of this cardiovascular disease is of special interest, focusing our attention on achieving a more effective control of the immune system. Finally, this review highlights the latest knowledge about nanotechnology as a powerful, modern, and promising therapeutic alternative applied to atherosclerotic disease, as well as warning of the potential complications with their use. Copyright © 2016 Sociedad Española de Arteriosclerosis. Publicado por Elsevier España, S.L.U. All rights reserved.

  5. Cardiovascular risk scores for coronary atherosclerosis.

    Science.gov (United States)

    Yalcin, Murat; Kardesoglu, Ejder; Aparci, Mustafa; Isilak, Zafer; Uz, Omer; Yiginer, Omer; Ozmen, Namik; Cingozbay, Bekir Yilmaz; Uzun, Mehmet; Cebeci, Bekir Sitki

    2012-10-01

    The objective of this study was to compare frequently used cardiovascular risk scores in predicting the presence of coronary artery disease (CAD) and 3-vessel disease. In 350 consecutive patients (218 men and 132 women) who underwent coronary angiography, the cardiovascular risk level was determined using the Framingham Risk Score (FRS), the Modified Framingham Risk Score (MFRS), the Prospective Cardiovascular Münster (PROCAM) score, and the Systematic Coronary Risk Evaluation (SCORE). The area under the curve for receiver operating characteristic curves showed that FRS had more predictive value than the other scores for CAD (area under curve, 0.76, P MFRS, PROCAM, and SCORE) may predict the presence and severity of coronary atherosclerosis.The FRS had better predictive value than the other scores.

  6. Antonio Boroni e il suo dramma giocoso „L’amore in musica“, Italský kulturní institut v Praze, 13. června 2015

    Czech Academy of Sciences Publication Activity Database

    Jonášová, Milada

    2016-01-01

    Roč. 53, č. 1 (2016), s. 99-101 ISSN 0018-7003. [Antonio Boroni e il suo dramma giocoso „L’amore in music a“. Praha, 13.06.2015] Institutional support: RVO:68378076 Keywords : Antonio Boroni * G. B. Locatelli * reception * Mozart * Salieri * Fischietti * Gassmann Subject RIV: AL - Art, Architecture, Cultural Heritage

  7. Gestos efêmeros e obras tangíveis: a trajetória de Antonio Manuel

    Directory of Open Access Journals (Sweden)

    Cynthia Marie Canejo

    2006-11-01

    Full Text Available Ainda que tributária do construtivismo brasileiro, a produção artística de Antonio Manuel se manteve única e, muitas vezes, radical. Este artigo examina as especificidades do trabalho do artista, principalmente a partir de suas semelhanças e diferenças com os postulados do neoconcretismo.Even though related to Brazilian constructivism, Antonio Manuel's artistic production has remained unique, and, sometimes, radical. This article examines the particularities of his work, mainly from the point of view of its relations to neoconcretism's postulates.

  8. Los artículos sobre libertad de imprenta de Bentham y Miguel Antonio Caro: divergencias y eventuales correspondencias

    Directory of Open Access Journals (Sweden)

    Gonzalo A. Ramírez Cleves

    2009-07-01

    Full Text Available El artículo analiza los escritos del jurista inglés Jeremy Bentham sobre libertad de prensa y su influencia en Venezuela y Colombia en el siglo XIX, teniendo en cuenta la publicación que se hizo de un artículo sobre el tema en La Bagatela de Antonio Nariño en 1811. El escrito compara el pensamiento de Bentham sobre el tema con las ideas conservadoras de Miguel Antonio Caro a finales del siglo XIX publicadas en el periódico El Nacional.

  9. Los artículos sobre libertad de imprenta de Bentham y Miguel Antonio Caro: divergencias y eventuales correspondencias

    Directory of Open Access Journals (Sweden)

    Gonzalo A. Ramírez Cleves

    2009-06-01

    Full Text Available El artículo analiza los escritos del jurista inglés jeremy bentham sobre libertad de prensa y su influencia en Venezuela y Colombia en el siglo XIX, teniendo en cuenta la publicación que se hizo de un artículo sobre el tema en La Bagatela de antonio nariño en 1811. El escrito compara el pensamiento de bentham sobre el tema con las ideas conservadoras de miGuel antonio caro a finales del siglo xix publicadas en el periódico El Nacional.

  10. Franco and José Antonio: Chief and Prophet of Spain. Construction of Charisma during the Civil War

    Directory of Open Access Journals (Sweden)

    María Luisa RICO GÓMEZ

    2016-07-01

    Full Text Available This paper examines how the person of the general Francisco Franco and of the Falangist leader Jose Antonio Primo de Rivera were transfigured symbolically by means of the construction and spread of its charismatic image into the speech, the rites and the liturgies of the ‘new State’ during the civil war into Spain from 1936 to 1939. The charismatic thing like carrier of an essence transcendente appeared in a dual way between the exaltation of Franco, the Caudillo, hero recognized as political chief for his warlike exploits, and the worship in memory of Jose Antonio, prophet dedicated to the death as redeeming sacrifice of Spain.

  11. A tradição esquecida: estudo sobre a sociologia de Antonio Candido

    Directory of Open Access Journals (Sweden)

    Jackson Luiz Carlos

    2001-01-01

    Full Text Available Este artigo pretende avaliar a importância de Antonio Candido nas Ciências Sociais brasileiras e a relação entre Sociologia e crítica literária na obra do autor. Nesse sentido, Os Parceiros do Rio Bonito (tese defenfida em 1954 na USP, publicada em livro em 1964 é filiado ao ensaísmo e aproximado de Formação da Literatura Brasileira (1959. Discute-se em que medida Os Parceiros do Rio Bonito deve ser lido como monografia antropológica e produto acadêmico da FFCL/USP e/ou como interpretação mais ampla da formação social brasileira. Nossa hipótese afirma que o livro responde, apesar da evidente distância temática, à mesma preocupação que orientou a redação de Formação da Literatura Brasileira, apontando para uma unidade interna à diversidade da produção intelectual de Antonio Candido, o que a vincula a problemas típicos da tradição ensaística brasileira.

  12. Archaeometric studies in the Franciscan convent of Santo Antonio - Recife, Pernambuco, Brazil

    International Nuclear Information System (INIS)

    Azevedo, Renata L.; Asfora, Viviane K.; Ribeiro, Guilherme B.; Ferreira, Joao Victor C.; Khoury, Helen J.; Sullasi, Henry S.L.; Rego, Nuno Jose S.; Mello, Jose Aylton C. de

    2011-01-01

    The purpose of this paper is to characterize the tiles placed on the walls of the Franciscan convent of Santo Antonio (Recife-PE) and to obtain information about the several expansions and structural reforms performed on the convent by dating the bricks. For this purpose, a portable energy dispersive X-Ray Fluorescence (EDXRF) was used to characterize the tiles. The dating of the bricks was performed using the Thermoluminescence (TL) technique. The results of the EDXRF analysis show that the dominant component of the white pigment is Lead [2PbCO 3 .Pb (OH) 2 ], used since the ancient times until the twentieth century, while the dominant element of the blue pigment is Cobalt (CoO.Al 2 O 3 ), that has been used from 1807 until nowadays. The TL dating of bricks indicate that there were walls with different periods of construction, being one built around 1765, with a deviation of 28 years, whereas other was built later, around 1874, with a deviation of 15 years. These results provide new data towards understanding how and when the Recife Franciscan Convent of Santo Antonio was designed and built, contributing to other research works presently underway on site. (author)

  13. Carnaval de Sodoma de Pedro Antonio Valdez: retratos y vestiduras travestis

    Directory of Open Access Journals (Sweden)

    Julio Penenrey Navarro

    2014-12-01

    Full Text Available El travestimiento y las identidades queer son temas obviados y desentendidos por la crítica literaria que la novela Carnaval de Sodoma (2002, del escritor dominicano Pedro Antonio Valdez, ha merecido hasta el momento. A través del surgimiento de tres personajes travestidos de la obra —Tora, el Barón del cementerio-La Fortunata y Changsán- Princesa de Jade— examinaremos cómo la acción travesti desestabiliza el imaginario de naturalización y de complementariedad que el discurso normativo ha asignado a los géneros tradicionales (masculino/femenino, y repensaremos nociones como género y sexualidad, comúnmente establecidas por el pensamiento heterocentrado como entidades fijas e inmutables. Cross-dressing and queer identities constitute themes that are ignored and neglected by the literary critic that the novel Carnaval de Sodoma (2002, by Dominican writer Pedro Antonio Valdez has had until now. We will analyze three transvestite characters —Tora, the Baron of the graveyard-La Fortunata and Changsán-Princess of Jade— and examine how the transvestite action destabilize the naturalization and complementarization imaginary that the normative discourse has assigned to the traditional genders (masculine/femenine. We will rethink notions such as gender and sexuality, usually established by the heterocentered thought as fixe and immutable entities.

  14. RELATO DE EXPERIENCIAS INICIAIS DO PRJETO DE EXTENSÃO ANTONIO GRAMSCI, UNIVALI, SC

    Directory of Open Access Journals (Sweden)

    Murilo Lyra Pinto

    2016-11-01

    Full Text Available O objetivo deste artigo é relatar as experiências iniciais vivenciadas, em 2015, pelo Projeto de Extensão Antonio Gramsci: fomentando a concepção ativista de educação, da Universidade do Vale do Itajaí, SC. A abordagem dialética foi adotada como método e matriz epistêmica. Na oficina-base do Projeto, intitulada Universidade, os extensionistas foram instigados para responder qual o papel da Universidade e que papel a Universidade deveria ter na sociedade brasileira. A síntese dos questionamentos deu-se na interlocução entre transformação, vontade coletiva e participação. Ancorados em Antonio Gramsci, concluíram que a produção de trabalhadores reflexivos e críticos para o Sistema Único de Saúde (SUS exige o caráter orgânico na formação acadêmica e que a vontade coletiva é uma atividade ético-política. A execução deste Projeto expressa a natureza pública da Instituição e seu compromisso com o desenvolvimento humano.

  15. El cardo, el ave y la verdad. Entrevista con el pintor Antonio López

    Directory of Open Access Journals (Sweden)

    Jean-Philippe Peynot

    2016-01-01

    Full Text Available Antonio López es reconocido como uno de los más grandes pintores actuales por numerosas instituciones y por un público muy amplio. Al escoger pintar su entorno más cercano, de manera realista y sin imponer siquiera un estilo, supo que su camino sería difícil y solitario, lejos de los críticos de arte, curadores, galeristas y otros actores de la escena contemporánea. De la fidelidad de su mirada nació una obra, y de esta obra nació el pintor, que nos habla en esta entrevista, al horizonte de una verdad. Entre otros reconocimientos Antonio López recibió el Premio Príncipe de Asturias de las Artes en 1985 y el Premio Velázquez de Artes Plásticas en 2006.

  16. Tradición y modernidad en la obra de Antonio López = Tradition and Modernity in Antonio López’s works

    Directory of Open Access Journals (Sweden)

    María Ruiz de Loizaga Martín

    2015-01-01

    Full Text Available Resumen: A lo largo de su trayectoria artística, son muchas y muy variadas las influencias que ha recibido Antonio López hasta emerger como el principal representante del realismo español. Esas fuentes tan diversas –pintores del Trecento y el Quattrocento, el cubismo, el surrealismo, la pintura metafísica, el mundo clásico, el arte español, Velázquez, Vermeer, etc.– reflejan su progresiva evolución pictórica, que no presenta rupturas, y evidencian la admiración que siente hacia otros artistas y su conocimiento de la historia del arte antiguo y contemporáneo. Asimismo, algunas de sus obras, como sus vistas aéreas, sugieren su comparación con el impresionismo. El papel que juega la fotografía es un elemento fundamental en esta comparativa. La admiración que despierta no es sólo a nivel profesional, sino también humano. A través de las entrevistas, el receptor es consciente de la humanidad de este genio y del sentido e intención última de su obra.Abstract: Antonio López has been the recipient of many different influences throughout his artistic career, crowned by the unofficial title of main figure of Spanish Realism. These sources, that range from Trecento and Quattrocento paintings to Cubism, Surrealism, metaphysical painting, the classic world, Spanish art, Velázquez or Vermeer show a steady pictorial development and demonstrate his admiration for other artists and his knowledge of Ancient and Contemporary art history. In addition, his aerial views can be compared with Impressionism. Photography’s role is a basic element in this comparison. His works trigger the admiration both from a technical and a human point of view. By the interviews, the public is aware of the humanity of this genius as well as the meaning and the final intention of his work.

  17. Cellular and Molecular Mechanisms of Diabetic Atherosclerosis: Herbal Medicines as a Potential Therapeutic Approach

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    Jinfan Tian

    2017-01-01

    Full Text Available An increasing number of patients diagnosed with diabetes mellitus eventually develop severe coronary atherosclerosis disease. Both type 1 and type 2 diabetes mellitus increase the risk of cardiovascular disease associated with atherosclerosis. The cellular and molecular mechanisms affecting the incidence of diabetic atherosclerosis are still unclear, as are appropriate strategies for the prevention and treatment of diabetic atherosclerosis. In this review, we discuss progress in the study of herbs as potential therapeutic agents for diabetic atherosclerosis.

  18. Antonio Gramsci

    DEFF Research Database (Denmark)

    Bryld, Claus

    2016-01-01

    Macchiavelli, socialisten Karl Marx og den liberale italienske filosof Benedetto Croce. På dette grundlag udformede han sin særlige 'praxisfilosofi' og sin særlige politikopfattelse, der vender sig mod eliternes indbyggede tendens til magtfudkommenhed. Hans værk fremstår den dag i dag som et idélaboratorium...

  19. Accelerated atherosclerosis in patients with systemic autoimmune diseases

    NARCIS (Netherlands)

    De Leeuw, K.; Kallenberg, Cees; Bijl, Marc; Shoenfeld, Y.; Gershwin, M.E.; Shoenfeld, Y; Gershwin, ME

    2005-01-01

    Systemic autoimmune diseases such as systemic lupus erythematosus and Wegener's granulomatosis are associated with a significantly increased prevalence of cardiovascular disease (CVD) compared with age- and sex-matched controls. Many risk factors are involved in the pathogenesis of atherosclerosis,

  20. Local Bone Marrow Renin-Angiotensin System and Atherosclerosis

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    Yavuz Beyazit

    2011-01-01

    Full Text Available Local hematopoietic bone marrow (BM renin-angiotensin system (RAS affects the growth, production, proliferation differentiation, and function of hematopoietic cells. Angiotensin II (Ang II, the dominant effector peptide of the RAS, regulates cellular growth in a wide variety of tissues in pathobiological states. RAS, especially Ang II and Ang II type 1 receptor (AT1R, has considerable proinflammatory and proatherogenic effects on the vessel wall, causing progression of atherosclerosis. Recent investigations, by analyzing several BM chimeric mice whose BM cells were positive or negative for AT1R, disclosed that AT1R in BM cells participates in the pathogenesis of atherosclerosis. Therefore, AT1R blocking not only in vascular cells but also in the BM could be an important therapeutic approach to prevent atherosclerosis. The aim of this paper is to review the function of local BM RAS in the pathogenesis of atherosclerosis.

  1. (18)F-FDG PET imaging of murine atherosclerosis

    DEFF Research Database (Denmark)

    Hag, Anne Mette Fisker; Pedersen, Sune Folke; Christoffersen, Christina

    2012-01-01

    To study whether (18)F-FDG can be used for in vivo imaging of atherogenesis by examining the correlation between (18)F-FDG uptake and gene expression of key molecular markers of atherosclerosis in apoE(-/-) mice....

  2. Extracranial cerebral arterial atherosclerosis in Iranian patients suffering ischemic strokes

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    Sayed Ali Mousavi

    2006-12-01

    Full Text Available BACKGROUND: To determine the distribution and severity of extracranial carotid arterial atherosclerosis in Iranian patients with ischemic stroke. METHODS: 328 patients with ischemic stroke were included in this study. Doppler ultrasound was used for evaluation of atherosclerosis in extracranial carotid arteries. The NASCET criteria were used to measure carotid stenosis. RESULTS: Ninety of 328 patients (27.4% were found to have atherosclerotic plaques; 40 of these patients were women and 50 were men. Sixty-eight patients (20.7% had artery stenosis <50%, 13 patients (3.95% had 50-70 % artery stenosis and 6 (1.8% had >70% artery stenosis. CONCLUSIONS: Extracranial atherosclerosis is not rare in Iranian patients with ischemic stroke, but most carotid artery lesions were plaques with <50% stenosis. KEY WORDS: Atherosclerosis, ischemic stroke, carotid stenosis.

  3. Recent advances in lipoprotein and atherosclerosis: A nutrigenomic approach

    OpenAIRE

    López, Sergio; Ortega, Almudena; Varela, Lourdes; Bermúdez, Beatriz; Muriana, Francisco JG; Abia, Rocío

    2009-01-01

    Atherosclerosis is a disease in which multiple factors contribute to the degeneration of the vascular wall. Many risk factors have been identified as having influence on the progression of atherosclerosis among them, the type of diet. Multifactorial interaction among lipoproteins, vascular wall cells, and inflammatory mediators has been recognised as the basis of atherogenesis. Dietary intake affects lipoprotein concentration and composition providing risk or protection at several stages of a...

  4. Implications of alcoholic cirrhosis in atherosclerosis of autopsied patients

    OpenAIRE

    Silveira, Luciano Alves Matias da; Torquato, Bianca Gonçalves Silva; Oliveira, Mariana Silva; Juliano, Guilherme Ribeiro; Oliveira, Lívia Ferreira; Cavellani, Camila Lourencini; Ramalho, Luciana Santos; Espindula, Ana Paula; Teixeira, Vicente de Paula Antunes; Ferraz, Mara Lúcia Fonseca

    2017-01-01

    Summary Introduction: Alcoholism is a major public health problem, which has a high social cost and affects many aspects of human activity. Liver disease is one of the first consequences of alcohol abuse, and steatosis, liver cirrhosis and hepatitis may occur. Other organs are also affected with pathological changes, such as pancreatitis, cardiomyopathies, dyslipidemias and atherosclerosis. Objective: To identify the occurrence and degree of atherosclerosis in alcohol-dependent individuals ...

  5. Antonio Mollari e l’architettura nelle Marche dal Neoclassico al Purismo / Antonio Mollari and architecture in Marche region from Neoclassicism to Purism

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    Fabio Mariano

    2015-02-01

    The early architectural "functionalist" Neoclassicism introduced in the Papal State by the genius of Vanvitelli, with his early works in the Marches, had defined a new design language and a particular simplified taste in architectural decorum, played on the widespread use of clay enriched with essential emphases stone, which will affect the architectural production in the Marches to beyond the eighteenth century. The Napoleonic invasion (1797 will shake the backwardness of the state papal introducing new modern principles of land management and planning, mapping and cadastral new tools, new types of architecture-related services, new roles assigned to public engineers and architects. Linearity, proportion and good taste became theoretical assumptions; constructive correctness and rational correspondence between functions and plans became the yardstick; a serene simplification of forms constantly connected to the economic program was married with recovery of the classical models and Vitruvian read back through the mediation treatises of Vignola and especially of Palladio. All news largely implemented after the Restoration of the Papal rule, where the professional figure of Antonio Mollari, after his exploits in the new Stock Exchange Building in Trieste, is inserted in the vein of architectural Purism. It was "more than a passing circumvention the neoclassical experience", it was a final declination of the broader cultural movement of the European neoclassical, by now exhausted, placed in a few decades, until the papacy of Pius IX, and before the next eclectic anthology of historical revivals.

  6. Life stress and atherosclerosis: a pathway through unhealthy lifestyle.

    Science.gov (United States)

    Mainous, Arch G; Everett, Charles J; Diaz, Vanessa A; Player, Marty S; Gebregziabher, Mulugeta; Smith, Daniel W

    2010-01-01

    To examine the relationship between a general measure of chronic life stress and atherosclerosis among middle aged adults without clinical cardiovascular disease via pathways through unhealthy lifestyle characteristics. We conducted an analysis of The Multi-Ethnic Study of Atherosclerosis (MESA). The MESA collected in 2000 includes 5,773 participants, aged 45-84. We computed standard regression techniques to examine the relationship between life stress and atherosclerosis as well as path analysis with hypothesized paths from stress to atherosclerosis through unhealthy lifestyle. Our outcome was sub-clinical atherosclerosis measured as presence of coronary artery calcification (CAC). A logistic regression adjusted for potential confounding variables along with the unhealthy lifestyle characteristics of smoking, excessive alcohol use, high caloric intake, sedentary lifestyle, and obesity yielded no significant relationship between chronic life stress (OR 0.93, 95% CI 0.80-1.08) and CAC. However, significant indirect pathways between chronic life stress and CAC through smoking (p = .007), and sedentary lifestyle (p = .03) and caloric intake (.002) through obesity were found. These results suggest that life stress is related to atherosclerosis once paths of unhealthy coping behaviors are considered.

  7. Hepatic JAK2 protects against atherosclerosis through circulating IGF-1.

    Science.gov (United States)

    Sivasubramaniyam, Tharini; Schroer, Stephanie A; Li, Angela; Luk, Cynthia T; Shi, Sally Yu; Besla, Rickvinder; Dodington, David W; Metherel, Adam H; Kitson, Alex P; Brunt, Jara J; Lopes, Joshua; Wagner, Kay-Uwe; Bazinet, Richard P; Bendeck, Michelle P; Robbins, Clinton S; Woo, Minna

    2017-07-20

    Atherosclerosis is considered both a metabolic and inflammatory disease; however, the specific tissue and signaling molecules that instigate and propagate this disease remain unclear. The liver is a central site of inflammation and lipid metabolism that is critical for atherosclerosis, and JAK2 is a key mediator of inflammation and, more recently, of hepatic lipid metabolism. However, precise effects of hepatic Jak2 on atherosclerosis remain unknown. We show here that hepatic Jak2 deficiency in atherosclerosis-prone mouse models exhibited accelerated atherosclerosis with increased plaque macrophages and decreased plaque smooth muscle cell content. JAK2's essential role in growth hormone signalling in liver that resulted in reduced IGF-1 with hepatic Jak2 deficiency played a causal role in exacerbating atherosclerosis. As such, restoring IGF-1 either pharmacologically or genetically attenuated atherosclerotic burden. Together, our data show hepatic Jak2 to play a protective role in atherogenesis through actions mediated by circulating IGF-1 and, to our knowledge, provide a novel liver-centric mechanism in atheroprotection.

  8. Macrophage Phenotype and Function in Different Stages of Atherosclerosis

    Science.gov (United States)

    Tabas, Ira; Bornfeldt, Karin E.

    2016-01-01

    The remarkable plasticity and plethora of biological functions performed by macrophages have enticed scientists to study these cells in relation to atherosclerosis for more than 50 years, and major discoveries continue to be made today. It is now understood that macrophages play important roles in all stages of atherosclerosis, from initiation of lesions and lesion expansion, to necrosis leading to rupture and the clinical manifestations of atherosclerosis, to resolution and regression of atherosclerotic lesions. Lesional macrophages are derived primarily from blood monocytes, although recent research has shown that lesional macrophage-like cells can also be derived from smooth muscle cells. Lesional macrophages take on different phenotypes depending on their environment and which intracellular signaling pathways are activated. Rather than a few distinct populations of macrophages, the phenotype of the lesional macrophage is more complex and likely changes during the different phases of atherosclerosis and with the extent of lipid and cholesterol loading, activation by a plethora of receptors, and metabolic state of the cells. These different phenotypes allow the macrophage to engulf lipids, dead cells, and other substances perceived as danger signals; efflux cholesterol to HDL; proliferate and migrate; undergo apoptosis and death; and secrete a large number of inflammatory and pro-resolving molecules. This review article, part of the Compendium on Atherosclerosis, discusses recent advances in our understanding of lesional macrophage phenotype and function in different stages of atherosclerosis. With the increasing understanding of the roles of lesional macrophages, new research areas and treatment strategies are beginning to emerge. PMID:26892964

  9. San Francisco folio, California, Tamalpais, San Francisco, Concord, San Mateo, and Haywards quadrangles

    Science.gov (United States)

    Lawson, Andrew Cowper

    1914-01-01

    The five sheets of the San Francisco folio the Tamalpais, Ban Francisco, Concord, Ban Mateo, and Haywards sheets map a territory lying between latitude 37° 30' and 38° and longitude 122° and 122° 45'. Large parts of four of these sheets cover the waters of the Bay of San Francisco or of the adjacent Pacific Ocean. (See fig. 1.) Within the area mapped are the cities of San Francisco, Oakland, Berkeley, Alameda, Ban Rafael, and San Mateo, and many smaller towns and villages. These cities, which have a population aggregating about 750,000, together form the largest and most important center of commercial and industrial activity on the west coast of the United States. The natural advantages afforded by a great harbor, where the railways from the east meet the ships from all ports of the world, have determined the site of a flourishing cosmopolitan, commercial city on the shores of San Francisco Bay. The bay is encircled by hilly and mountainous country diversified by fertile valley lands and divides the territory mapped into two rather contrasted parts, the western part being again divided by the Golden Gate. It will therefore be convenient to sketch the geographic features under four headings (1) the area east of San Francisco Bay; (2) the San Francisco Peninsula; (3) the Marin Peninsula; (4) San Francisco Bay. (See fig. 2.)

  10. El mayor laboratorio en física del mundo Juan Antonio Rubio, candidato a dirigir el CERN

    CERN Multimedia

    2007-01-01

    The spanish Government presented last Friday at the CERN Council Juan Antonio Rubio, as candidate for the post of Director General of CERN. It's the first time that the spanish Government proposes a candidate for the Direction of this international research center. (2/3 page)

  11. O conceito de redução estrutural na crítica de Antonio Candido

    Directory of Open Access Journals (Sweden)

    Franscisca Fernanda de Sales Teixeira

    2018-04-01

    Full Text Available RESUMO: O presente artigo apresenta o conceito de redução estrutural na crítica literária de Antonio Candido. Para tanto, foram analisados três ensaios referentes a obras da literatura nacional: “De cortiço a cortiço”, “Crítica e sociologia” e “Dialética da malandragem”. A partir deles, investigou-se como se dá o processo de formalização em cada obra, construindo assim uma compreensão acerca da estrutura literária e suas relações com a internalização, no romance, de aspectos externos à obra. PALAVRAS-CHAVE: Antonio Candido Redução estrutural, Internalização do externo. __________________________________ ABSTRACT: This abstract presents a summary of literary analysis papers based on reviews writen by Antonio Candido. For that, three of his essays were analized: “De cortiço a cortiço”, “Crítica e sociologia” and “Dialética da malandragem”. From these studies, it was possible to investigate the formalization process in each work, constructing the comprehension around the literary structures and the aspects surrounding the essence of the novels.  KEYWORDS: Antonio Candido, Structural reduction, Internalization of the external.

  12. Stock of immobilized metals in 'Jose Antonio Alzate' dam mud sediment samples in the State of Mexico, Mexico

    International Nuclear Information System (INIS)

    Rodriguez, S.A.; Avila-Perez, P.

    1997-01-01

    'Jose Antonio Alzate' dam mud sediment samples were collected from six sampling sites. The samples were analyzed by combining multielemental studies with structural details, including heating to very high temperatures. Characterization of mud sediment samples have been shown to have low concentrations of metals (Cr, Mn, Ni, Cu, Zn, Pb). No systematic trend was observed as a function of the sampling points. (author)

  13. Rio de Janeirost Tallinna, 75 kraadi Celsiuse järgi / Antonio Claudio Carvalho ; tõlk. Reet Varblane

    Index Scriptorium Estoniae

    Carvalho, Antonio Claudio

    2006-01-01

    Juhendaja Antonio Claudio Carvalho Eesti Kunstiakadeemia üliõpilastele toimunud maalimeistriklassist "Ava oma silmad" ja lõpunäitusest Eesti Kunstiakadeemia galeriis. Enne näitust näitasid üliõpilased tööd, mida nad ise pidasid parimaks, kunstikriitik Heie Treierile

  14. Nitric oxide bioavailability dysfunction involves in atherosclerosis.

    Science.gov (United States)

    Chen, Jing-Yi; Ye, Zi-Xin; Wang, Xiu-Fen; Chang, Jian; Yang, Mei-Wen; Zhong, Hua-Hua; Hong, Fen-Fang; Yang, Shu-Long

    2018-01-01

    The pathological characteristics of atherosclerosis (AS) include lipid accumulation, fibrosis formation and atherosclerotic plaque produced in artery intima, which leads to vascular sclerosis, lumen stenosis and irritates the ischemic changes of corresponding organs. Endothelial dysfunction was closely associated with AS. Nitric oxide (NO) is a multifunctional signaling molecule involved in the maintenance of metabolic and cardiovascular homeostasis. NO is also a potent endogenous vasodilator and enters for the key processes that suppresses the formation vascular lesion even AS. NO bioavailability indicates the production and utilization of endothelial NO in organisms, its decrease is related to oxidative stress, lipid infiltration, the expressions of some inflammatory factors and the alteration of vascular tone, which plays an important role in endothelial dysfunction. The enhancement of arginase activity and the increase in asymmetric dimethylarginine and hyperhomocysteinemia levels all contribute to AS by intervening NO bioavailability in human beings. Diabetes mellitus, obesity, chronic kidney disease and smoking, etc., also participate in AS by influencing NO bioavailability and NO level. Here, we reviewed the relationship between NO bioavailability and AS according the newest literatures. Copyright © 2017. Published by Elsevier Masson SAS.

  15. Noninvasive Diagnostic Technique in Stenotic Coronary Atherosclerosis

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    A. Yu. Vasilyev

    2005-01-01

    Full Text Available Objective: to determine the sensitivity and specificity of combined stress echocardiography (EchoCG using dipyri-damole and dobutamine in diagnosing and defining the extent of stenotic coronary lesions in coronary heart disease (CHD in a group of critically ill patients who are unable to perform a physical exercise.Materials and methods: the study included 57 male patients with suspected acute coronary syndrome who underwent stress EchoCG using dipyridamole in high doses in combination with dobutamine, as well as coronary angiography.Results: stress EchoCG could bring up to the diagnostic criteria in all the patients, of whom 9 patients were found at coronary angiography to have no coronary lesion, 34 and 14 patients had one- and many-vessel lesions, respectively. The sensitivity and specificity of combined stress EchoCG were significantly higher than those of EchoCG used in the diagnosis of CHD.Conclusion: stress EchoCG using dipyridamole in combination with dobutamine is a highly informative safe noninvasive technique for diagnosing CHD, its helps to identify patients with atypical acute coronary syndrome and to form a group of patients to be subject to urgent coronarography and angiosurgical intervention. The pattern of segmental contractile disorders at the height of exercise during combined stress Echo-CG makes it possible to define the site of stenotic coronary atherosclerosis with 97.3% sensitivity and to diagnose many-vessel lesion with 100% sensitivity and 100%specificity.

  16. Molecular Imaging of Inflammation in Atherosclerosis

    Science.gov (United States)

    Wildgruber, Moritz; Swirski, Filip K.; Zernecke, Alma

    2013-01-01

    Acute rupture of vulnerable plaques frequently leads to myocardial infarction and stroke. Within the last decades, several cellular and molecular players have been identified that promote atherosclerotic lesion formation, maturation and plaque rupture. It is now widely recognized that inflammation of the vessel wall and distinct leukocyte subsets are involved throughout all phases of atherosclerotic lesion development. The mechanisms that render a stable plaque unstable and prone to rupture, however, remain unknown and the identification of the vulnerable plaque remains a major challenge in cardiovascular medicine. Imaging technologies used in the clinic offer minimal information about the underlying biology and potential risk for rupture. New imaging technologies are therefore being developed, and in the preclinical setting have enabled new and dynamic insights into the vessel wall for a better understanding of this complex disease. Molecular imaging has the potential to track biological processes, such as the activity of cellular and molecular biomarkers in vivo and over time. Similarly, novel imaging technologies specifically detect effects of therapies that aim to stabilize vulnerable plaques and silence vascular inflammation. Here we will review the potential of established and new molecular imaging technologies in the setting of atherosclerosis, and discuss the cumbersome steps required for translating molecular imaging approaches into the clinic. PMID:24312156

  17. Caribe y exilio en La isla que se repite de Antonio Benítez Rojo

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    Arcadio Díaz Quiñones

    2007-09-01

    Full Text Available This paper suggests a reading of Antonio Benítez Rojo's unavoidable essay La isla que se repite (1989, in order to approach and meditate on Caribbean cultures, attempting both to delineate a possible understanding of the relationship between his poetics and exile, and to analyse some of his choices as an intellectual and the way he conceived Caribbean in his essays. In the map drawn by Benítez Rojo, paradise islands appear along with those ruled by violence and death, and are sometimes confused. Plantation and Utopia are the main topics. Essays from La isla que se repite allow us to examine his wish to link his work to other traditions by means of a long rodeo through the rich Caribbean cultural matrices. It was his way to escape and transcend "nation" authoritarian discourse prevailing in modern Cuban history.

  18. Caribe y exilio en La isla que se repite de Antonio Benítez Rojo

    Directory of Open Access Journals (Sweden)

    Arcadio Díaz Quiñones

    2006-11-01

    Full Text Available This paper suggests a reading of Antonio Benítez Rojo's unavoidable essay La isla que se repite (1989, in order to approach and meditate on Caribbean cultures, attempting both to delineate a possible understanding of the relationship between his poetics and exile, and to analyse some of his choices as an intellectual and the way he conceived Caribbean in his essays. In the map drawn by Benítez Rojo, paradise islands appear along with those ruled by violence and death, and are sometimes confused. Plantation and Utopia are the main topics. Essays from La isla que se repite allow us to examine his wish to link his work to other traditions by means of a long rodeo through the rich Caribbean cultural matrices. It was his way to escape and transcend "nation" authoritarian discourse prevailing in modern Cuban history.

  19. Columbian Secrets: Cristóbal Colón by Leonardo Balada and Antonio Gala

    Directory of Open Access Journals (Sweden)

    José Elías Gutiérrez Meza

    2016-11-01

    Full Text Available The play Cristóbal Colón premiered in 1989 at the Teatro del Liceu. Composed by the musician Leonardo Balada and the playwright Antonio Gala, this opera was commissioned by the Sociedad Estatal Quinto Centenario as part of the festivities organized by the Spanish government to commemorate the Discovery of America. Unlike the so-called "des-celebración del 92", Cristóbal Colón champions the figure of the discoverer and emphasizes the participation of Spain through the praised role of Martín Alonso Pinzón. However, the opera was cut at the last minute. This article asserts that such alteration may have been the result of political censorship attempting to counteract the criticism of the Discovery of America contained in the original version.

  20. Sul soggiorno del pittore Antonio Mancini in Irlanda nell’autunno del 1907

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    Michele Amedei

    2014-07-01

    Full Text Available This essay focuses on the portraits painted by Antonio Mancini (Rome, 1852-1930 during his stay in Dublin, in autumn 1907. Mancini, who belonged to the Italian Verismo movement, painted several self-portraits as well as portraits of well known Irish figures including Ruth Shine (Hugh Lane’s sister, Lady Augusta Gregory and William Butler Yeats. For the Irish intellectuals he met in Dublin Mancini became a symbol of individuality, humility and sincerity. As a result, Mancini’s imagination may be interpreted in relation with that of Martin, the young protagonist of Yeats and Lady Gregory’s play The Unicorn from the Stars (1907. This study concludes with an interpretation of Mancini’s painting entitled The Maker of Figures donated by John Singer Sargent to the Dublin City Gallery The Hugh Lane in the early 1900s.

  1. Entrevista a Antonio Álamo: Dramaturgo y director del teatro Lope De Vega

    Directory of Open Access Journals (Sweden)

    Valerio Durán

    2012-04-01

    Full Text Available Antonio Álamo es mucho más que un dramaturgo. Desde 2004 es el director del Teatro Lope de Vega de Sevilla, una faceta que deja entrever sus inquietudes por la escena teatral, la novela, y su pasión por los clásicos de siempre. Este cordobés licenciado en Derecho es un erudito de las letras y representa en pleno siglo XXI la frescura de un buen conocedor del mundo del teatro que acepta los nuevos cambios de la escena actual. A pesar de su juventud, ha escrito obras de teatro, novelas, relatos y ensayos, y sus innovadoras ideas le han dado grandes éxitos a nivel personal y profesional.

  2. Fundamentos de Inteligencia Artificial: Entrevista con Antonio Benítez

    Directory of Open Access Journals (Sweden)

    Asier Arias

    2012-07-01

    Full Text Available Antonio Benítez, profesor de Lógica en la Universidad Complutense de Madrid, ha dedicado buena parte de su labor docente e investigadora a la inteligencia artificial y a la filosofía de la mente y de la ciencia cognitiva. Recientemente ha publicado una obra en tres volúmenes titulada Fundamentos de Inteligencia Artificial (el tercer volumen, dedicado a la inteligencia artificial bioinspirada, aparecerá en los próximos meses. La misma ofrece una guía práctica de introducción a la programación en inteligencia artificial de clara y cabal factura, además de una cuidada introducción a los aspectos teóricos de la disciplina. En esta entrevista nos habla de esta obra y de la ciencia cognitiva en general.

  3. Drawings for an exacting author: illustrations from Giovanni Antonio Scopoli's "Deliciae florae et faunae insubricae".

    Science.gov (United States)

    Siviero, Monica; Violani, Carlo

    2006-01-01

    Giovanni Antonio Scopoli (1723-1788) was one of the most versatile naturalists in eighteenth-century Italy. In 1785, Scopoli conceived the ambitious publication, "Deliciae florae et faunae insubricae". Appearing in installments, this included descriptions and illustrations of plants, animals and minerals found in northern Italy. Unfortunately, Scopoli's sudden death halted publication of the "Deliciae" after its third installment. Recently, a corpus of 98 paintings, in the gouache style, were discovered in the Biblioteca Universitaria of Pavia. These gouaches appear to be the basis for plates planned in future installments of the "Deliciae". Marginal notes in Scopoli's handwriting are included. Because Scopoli's plant and animal specimens have been destroyed or dispersed, these drawings are crucial for reconstructing his scientific opus. Combined with other documents, Scopoli's marginal notes also reveal his exacting standards. He criticized the way his artists had poorly rendered the scientific details of the paintings.

  4. Razonamiento a priori y argumento ontológico en Antonio Rosmini

    Directory of Open Access Journals (Sweden)

    Juan F. Franck

    2013-11-01

    Full Text Available Rosmini’s criticism of the ontological argument finds its place between those of Aquinas and of Kant. With the former he shares the denial of the evidence of God’s essence quoad nos, and with the latter, his acknowledgment of the decisive character of the nucleus of the ontological argument for all other proofs of God’s existence. Such nucleus consists for Rosmini in the possibility of developing an a priori reasoning, different from the ontological one, be it in its Anselmian, Cartesian or Leibnizian form, which would justify the validity of the other proofs and the fascination exercised by the ontological argument. Key words: A Priori Reasoning, Ontological Argument, Antonio Rosmini.

  5. 76 FR 1386 - Safety Zone; Centennial of Naval Aviation Kickoff, San Diego Bay, San Diego, CA

    Science.gov (United States)

    2011-01-10

    ...-AA00 Safety Zone; Centennial of Naval Aviation Kickoff, San Diego Bay, San Diego, CA AGENCY: Coast... zone on the navigable waters of San Diego Bay in San Diego, CA in support of the Centennial of Naval... February 12, 2010, the Centennial of Naval Aviation Kickoff will take place in San Diego Bay. In support of...

  6. Arte e movimento estudantil: análise de uma obra de Antonio Manuel

    Directory of Open Access Journals (Sweden)

    Artur Freitas

    2005-01-01

    Full Text Available Podem as manifestações visuais, e no limite a própria visualidade, participar crítica e reflexivamente dos grandes debates do espaço público? Em linhas gerais, é justamente a crença nesse poder de intervenção crítica que manteve acesa, no caso das artes plásticas, uma intensa atividade pública, contestatória e coletiva das vanguardas brasileiras durante o regime militar, sobretudo em seus primeiros anos de vigência. E é a partir desse contexto histórico que este artigo pretende analisar algumas implicações estéticas e ideológicas presentes na obra Movimento estudantil 68, serigrafia de Antonio Manuel premiada no Salão Paranaense de 1968. Produzida em plena efervescência política do movimento estudantil, mas exibida ao público nos primeiros dias de vigência do Ato Institucional nº 5, Movimento estudantil 68 será aqui entendida como uma trama discursiva em que se cruzam história e visualidade.Can the visual manifestations participate critic and reflexively of the great debates of the public space? Usually, during the first years of military regime, the plastic arts believed in this participation, and this faith sustained the public, oppositional and collective activity of the Brazilian vanguards. In this historical context, therefore, this article will analyze some aesthetic and ideological implications presents in the work Movimento estudantil 68, engraving of Antonio Manuel rewarded in the Salão Paranaense of 1968. Movimento estudantil 68 was produced in the political effervescence peak of student movement, but it was exhibited for the public in the first days ofAct Institutional number 5.Thus, this art work will be understood here as a discursive plot, a crossing between history and visuality.

  7. Francisco Antonio Zea: periodista, botánico y político

    Directory of Open Access Journals (Sweden)

    Soto Arango, Diana E.

    1996-06-01

    Full Text Available This work analyzes the journalistic facet of Francisco Antonio Zea, whose first article, «Avisos de Hebephilo», was published in 1791 in the Papel Periódico de la ciudad de Santa Fé de Bogotá. His interest for the press shows at his stage of student in the National Institute of France, but won't be up to 1803, at his return to Madrid, when he proves his talent for the organization and journalistic administration on The Mercury and on the Gazette de Madrid. Later on, being manager of the Royal Botanical Garden of Madrid, he shares the management of the Semanario de Agricultura y Artes, and, finally, in 1818 establishes and directs the Venezuelan Correo del Orinoco.

    Este trabajo analiza la faceta periodística de Francisco Antonio Zea, cuyo primer artículo, «Avisos de Hebephilo», se publicó en 1791 en el Papel Periódico de la ciudad de Santa Fé de Bogota. Su interés por la prensa se manifiesta en su etapa de estudiante en el Instituto Nacional de Francia, pero no será hasta 1803, a su regreso a Madrid, cuando evidencie sus dotes para la organización y dirección periodísticas en El Mercurio y en la Gaceta de Madrid. Posteriormente, siendo director del Real Jardín Botánico de Madrid, comparte la dirección del Semanario de Agricultura y Artes, y, finalmente, en 1818 funda y dirige el venezolano Correo del Orinoco.

  8. ANTONIO DE MONTSERRAT – LA RUTA DE LA SEDA Y LOS CAMINOS SECRETOS DEL TANTRA

    Directory of Open Access Journals (Sweden)

    Oscar R. Gómez

    2016-01-01

    Full Text Available En este artículo se presenta la biografía de Antonio de Monserrat con el objeto de insertar en el pensamiento crítico budista a quien se considera el primer occidental iniciado en la filosofía tántrica e impulsor de ésta en Occidente a través de la Compañía de Jesús. Para ello, primero se hace un recorrido histórico que pone en foco cómo el budismo es desplazado de la India y se refugia entre las poblaciones de Asia central como la etnia Uigur en la actual Turquestán, cómo es adoptado por los emperadores chinos y se expande a lo largo de toda la Ruta de la Seda. La combinación del budismo indio con influencias occidentales (grecobudismo dio origen a diversas escuelas budistas en Asia Central y en China. Luego se caracteriza en forma sintética la versión esotérica que adquiere el budismo (el tantra y que se consolida en el siglo VIII en el Tíbet como budismo vajrayana (tántrico. Ésta es la forma de budismo que toman los gobernantes, que promueve la igualdad completa de personas y género, la idea del sujeto como una construcción de la cultura y la noción de deidades metafóricas —útiles para modelar el carácter de las personas pero de absoluta inexistencia— además del postulado budista de verdad relativa. Esta visión no teísta —o transteísta, como Gómez la prefiere llamar— se reflejaba en la total tolerancia religiosa del imperio Chino, Uigur y Mongol, que garantizaba la seguridad y el libre intercambio por la Ruta de la Seda. Es esta visión de sujetos no divididos en castas ni diferenciados por sangre lo que maravilla a de Montserrat al decir que los tibetanos “no tienen reyes entre sí” e inflama la avidez de quienes viajaron especialmente (a partir de los escritos de éste a iniciarse en el budismo tántrico tibetano como los jesuitas Antonio de Andrade y Juan de Brito. El tercer apartado se dedica de lleno a la biografía de Antonio de Monserrat y a precisar su contacto con el tantra. Abstract This

  9. Costo institucional de la crisis hipertensiva en el policlínico "Antonio Maceo" Institutional cost of hypertensive crisis in the "Antonio Maceo" polyclinic

    Directory of Open Access Journals (Sweden)

    Yosvany Tabares Silverio

    2011-06-01

    Full Text Available Introducción: la hipertensión arterial afecta la salud de las poblaciones en todas las partes del mundo. Representa por sí misma una enfermedad y también un factor de riesgo para otras afecciones cardiovasculares. Su impacto es en el área de la epidemiología, la salud pública, y en el aspecto económico. Objetivo: determinar el costo institucional de la atención al paciente con crisis hipertensiva en el servicio urgencia del policlínico "Antonio Maceo" de La Habana en el primer semestre del año 2008. Métodos: se realizó un estudio del tipo de descripción de costos. El enfoque metodológico utilizado fue el costo de la enfermedad, siguiendo los pasos recomendados en la Guía Metodológica para las Evaluaciones Económicas en Salud en Cuba. Los costos fueron expresados en pesos cubanos no convertibles del año 2008. La perspectiva de análisis adoptada fue la institucional. El universo de estudio estuvo constituido por 216 pacientes. En el cálculo del costo total institucional se consideraron las variables: costo por medicamentos, por medios diagnósticos, por salarios, entre otras. Resultados: se estudiaron 209 pacientes con urgencia hipertensiva (96,8 % y 7 con emergencia hipertensiva (3,2 %. El costo total de la atención del paciente con crisis hipertensiva ascendió a 5 451,68 pesos en moneda nacional y el costo promedio por paciente fue de 25,23. Conclusiones: el costo mayor en la atención al paciente con crisis hipertensiva estuvo relacionado con el salario directo. La adecuada dispensarización y tratamiento de los pacientes hipertensos pudiera disminuir el costo de la atención médica.Introduction: high blood pressure affects the health of populations at world scale. By itself represent a disease and a risk factor for other cardiovascular affections. Its impact is on the epidemiology, public health areas and in the economic feature. Objective: to determine the institutional cost of the patient care with hypertensive crisis

  10. Uso e diversidade de plantas medicinais em Santo Antonio do Leverger, MT, Brasil Use and diversity of medicinal plants in Santo Antonio do Leverger, MT, Brazil

    Directory of Open Access Journals (Sweden)

    Maria Christina de Mello Amorozo

    2002-04-01

    Full Text Available O presente trabalho tem como objetivo fazer o levantamento etnobotânico de plantas com usos terapêuticos no município de Santo Antonio do Leverger, MT, e estimar a diversidade de espécies usadas. Foram entrevistados residentes adultos de ambos os sexos, junto com os quais foram coletadas as plantas, depositadas no Herbarium Rioclarense (HRCB. Identificaram-se 228 espécies, pertencentes a 73 famílias; 56% delas crescem espontaneamente em ambientes naturais ou antropicamente modificados, 41% são cultivadas e 3% são compradas. Os índices de diversidade encontrados comparam-se aos mais altos registrados na literatura para plantas medicinais em outras áreas tropicais. A riqueza e diversidade das plantas espontâneas podem espelhar até certo ponto a riqueza e diversidade de espécies no ambiente, enquanto tais parâmetros para as espécies cultivadas estariam mais ligados a fatores sócio-culturais que promovam a introdução de novas plantas e informações de uso a partir de fontes externas. Sugere-se que quando comunidades tradicionais se tornam mais expostas à sociedade nacional, o número de espécies e o conhecimento acerca de seu uso podem sofrer inicialmente um acréscimo, por aportes externos; mas, com o aprofundamento do contato, e as mudanças sócio-econômicas decorrentes, a tendência será que as plantas usadas com fins terapêuticos restrinjam-se às espécies cultivadas e invasoras cosmopolitas.This work describes an ethnobotanical survey of medicinal plants in Santo Antonio do Leverger Municipality, Mato Grosso State, Brazil and estimates the diversity of species with therapeutic use. Adult dwellers, male and female, were interviewed and plant gathering undertaken with their assistance. Voucher specimens were deposited at the Herbarium Rioclarense (HRCB. 228 species were identified, belonging to 73 families; 56% of the species grow spontaneously in natural and anthropically modified habitats, 41% are cultivated and 3% are

  11. Riparian Habitat - San Joaquin River

    Data.gov (United States)

    California Natural Resource Agency — The immediate focus of this study is to identify, describe and map the extent and diversity of riparian habitats found along the main stem of the San Joaquin River,...

  12. Heme oxygenase-1, oxidation, inflammation and atherosclerosis

    Directory of Open Access Journals (Sweden)

    Jesus A Araujo

    2012-07-01

    Full Text Available Atherosclerosis is an inflammatory process of the vascular wall characterized by the infiltration of lipids and inflammatory cells. Oxidative modifications of infiltrating low density lipoproteins and induction of oxidative stress play a major role in lipid retention in the vascular wall, uptake by macrophages and generation of foam cells, a hallmark of this disorder. The vasculature has a plethora of protective resources against oxidation and inflammation, many of them regulated by the Nrf2 transcription factor. Heme oxygenase-1 (HO-1 is a Nrf2-regulated gene that plays a critical role in the prevention of vascular inflammation. It is the inducible isoform of heme oxygenase, responsible for the oxidative cleavage of heme groups leading to the generation of biliverdin, carbon monoxide and release of ferrous iron. HO-1 has important antioxidant, antiinflammatory, antiapoptotic, antiproliferative and immunomodulatory effects in vascular cells, most of which play a significant role in the protection against atherogenesis. HO-1 may also be an important feature in macrophage differentiation and polarization to certain subtypes. The biological effects of HO-1 are largely attributable to its enzymatic activity, which can be conceived as a system with three arms of action, corresponding to its three enzymatic byproducts. HO-1 mediated vascular protection may be due to a combination of systemic and vascular local effects. It is usually expressed at low levels but can be highly upregulated in the presence of several proatherogenic stimuli. The HO-1 system is amenable for use in the development of new therapies, some of them currently under experimental and clinical trials. Interestingly, in contrast to the HO-1 antiatherogenic actions, the expression of its transcriptional regulator Nrf2 leads to proatherogenic effects instead. This article reviews the evidence that supports the antiatherogenic role of HO-1, potential pathways and mechanisms mediating

  13. High prevalence of COPD in atherosclerosis patients

    Directory of Open Access Journals (Sweden)

    Tuleta I

    2017-10-01

    Full Text Available Izabela Tuleta, Tarik Farrag, Laura Busse, Carmen Pizarro, Christian Schaefer, Simon Pingel, Georg Nickenig, Dirk Skowasch, Nadjib Schahab Department of Internal Medicine II – Cardiology, Pulmonology and Angiology, University of Bonn, Bonn, Germany Abstract: Atherosclerosis and COPD are both systemic inflammatory diseases that may influence each other. The aim of the present study was to determine the prevalence of COPD in patients with cerebral and/or peripheral artery disease and to assess factors associated with the presence of COPD. Following the diagnosis of cerebral and/or peripheral artery disease by means of duplex sonography, 166 consecutive patients underwent body plethysmography with capillary blood gas analysis. Thereafter, blood tests with determination of different parameters such as lipid profile, inflammatory and coagulation markers were conducted in remaining 136 patients who fulfilled inclusion criteria of the study. Thirty-six out of 136 patients suffered from COPD, mostly in early stages of the disease. Residual volume indicating emphysema was increased (162.9%±55.9% vs 124.5%±37.0%, p<0.05 and diffusion capacity was decreased (55.1%±19.5% vs 75.3%±18.6%, p<0.05 in COPD patients vs non-COPD group. In capillary blood gas analysis, COPD patients had lower partial pressure of oxygen (70.9±11.5 vs 75.2±11.0 mmHg, p<0.05 and higher partial pressure of carbon dioxide (36.8±7.5 vs 34.4±4.4 mmHg, p<0.05 compared with non-COPD individuals. Presence of COPD was associated with predominance of diabetes mellitus, interleukin-8-related systemic neutrophilic inflammation and anemia. In conclusion, COPD is highly prevalent in patients with atherosclerotic artery disease. Keywords: cerebral artery disease, peripheral artery disease, lung function, capillary blood gas, diabetes mellitus, inflammation, interleukin-8, anemia

  14. Radiation-induced carotid artery atherosclerosis

    International Nuclear Information System (INIS)

    Gujral, Dorothy M.; Chahal, Navtej; Senior, Roxy; Harrington, Kevin J.; Nutting, Christopher M.

    2014-01-01

    Purpose: Carotid arteries frequently receive significant doses of radiation as collateral structures in the treatment of malignant diseases. Vascular injury following treatment may result in carotid artery stenosis (CAS) and increased risk of stroke and transient ischaemic attack (TIA). This systematic review examines the effect of radiotherapy (RT) on the carotid arteries, looking at the incidence of stroke in patients receiving neck radiotherapy. In addition, we consider possible surrogate endpoints such as CAS and carotid intima-medial thickness (CIMT) and summarise the evidence for radiation-induced carotid atherosclerosis. Materials and methods: From 853 references, 34 articles met the criteria for inclusion in this systematic review. These papers described 9 studies investigating the incidence of stroke/TIA in irradiated patients, 11 looking at CAS, and 14 examining CIMT. Results: The majority of studies utilised suboptimally-matched controls for each endpoint. The relative risk of stroke in irradiated patients ranged from 1.12 in patients with breast cancer to 5.6 in patients treated for head and neck cancer. The prevalence of CAS was increased by 16–55%, with the more modest increase seen in a study using matched controls. CIMT was increased in irradiated carotid arteries by 18–40%. Only two matched-control studies demonstrated a significant increase in CIMT of 36% and 22% (p = 0.003 and <0.001, respectively). Early prospective data demonstrated a significant increase in CIMT in irradiated arteries at 1 and 2 years after RT (p < 0.001 and <0.01, respectively). Conclusions: The incidence of stroke was significantly increased in patients receiving RT to the neck. There was a consistent difference in CAS and CIMT between irradiated and unirradiated carotid arteries. Future studies should optimise control groups

  15. RIP3-dependent necrosis induced inflammation exacerbates atherosclerosis

    Energy Technology Data Exchange (ETDEWEB)

    Meng, Lingjun, E-mail: menglingjun@nibs.ac.cn [College of Biological Sciences, China Agricultural University, Beijing 100094 (China); National Institute of Biological Sciences, Beijing 102206 (China); Jin, Wei [Institute for Immunology, Tsinghua University, Beijing 100084 (China); Wang, Yuhui [Institute of Cardiovascular Sciences, Health Science Center, Peking University, Beijing 100191 (China); Huang, Huanwei; Li, Jia; Zhang, Cai [National Institute of Biological Sciences, Beijing 102206 (China)

    2016-04-29

    Atherothrombotic vascular disease is already the leading cause of mortality worldwide. Atherosclerosis shares features with diseases caused by chronic inflammation. More attention should concentrates on the innate immunity effect atherosclerosis progress. RIP3 (receptor-interacting protein kinase 3) act through the transcription factor named Nr4a3 (Nuclear orphan receptors) to regulate cytokine production. Deletion RIP3 decreases IL-1α production. Injection of anti-IL-1α antibody protects against the progress of atherosclerosis in ApoE −/− mice. RIP3 as a molecular switch in necrosis, controls macrophage necrotic death caused inflammation. Inhibiting necrosis will certainly reduce atherosclerosis through limit inflammation. Necrotic cell death caused systemic inflammation exacerbated cardiovascular disease. Inhibition of necrosis may yield novel therapeutic targets for treatment in years to come. - Highlights: • RIP3 regulate the Nr4a3 to control cytokine production. • Deletion RIP3 decreases IL-1a production. • Injection anti-IL-1a antibody protects against the progress of atherosclerosis. • RIP3 controls macrophage necrotic dead caused inflammation.

  16. Frequency of Subclinical Atherosclerosis in Brazilian HIV-Infected Patients.

    Science.gov (United States)

    Salmazo, Péricles Sidnei; Bazan, Silméia Garcia Zanati; Shiraishi, Flávio Gobbis; Bazan, Rodrigo; Okoshi, Katashi; Hueb, João Carlos

    2018-04-09

    AIDS as well as atherosclerosis are important public health problems. The longer survival among HIV-infected is associated with increased number of cardiovascular events in this population, and this association is not fully understood. To identify the frequency of subclinical atherosclerosis in HIV-infected patients compared to control subjects; to analyze associations between atherosclerosis and clinical and laboratory variables, cardiovascular risk factors, and the Framingham coronary heart disease risk score (FCRS). Prospective cross-sectional case-control study assessing the presence of subclinical atherosclerosis in 264 HIV-infected patients and 279 controls. Clinical evaluation included ultrasound examination of the carotid arteries, arterial stiffness by pulse wave velocity (PWV) and augmentation index (AIx), laboratory analysis of peripheral blood, and cardiovascular risk according to FCRS criteria. The significance level adopted in the statistical analysis was p media thickness was higher in the HIV group than in controls (p media thickness, was not associated with carotid plaque frequency, and did not alter the mechanical characteristics of the arterial system (PWV and AIx). HIV-infected patients are at increased risk of atherosclerosis in association with classical cardiovascular risk factors. Treatment with protease inhibitors does not promote functional changes in the arteries, and shows no association with increased frequency of atherosclerotic plaques in carotid arteries. The FCRS may be inappropriate for this population.

  17. Suppression of atherosclerosis by synthetic REV-ERB agonist

    Energy Technology Data Exchange (ETDEWEB)

    Sitaula, Sadichha [Department of Molecular Therapeutics, The Scripps Research Institute, Jupiter, FL 33458 (United States); Billon, Cyrielle [Department of Pharmacological & Physiological Science, Saint Louis University School of Medicine, St. Louis, MO 63104 (United States); Kamenecka, Theodore M.; Solt, Laura A. [Department of Molecular Therapeutics, The Scripps Research Institute, Jupiter, FL 33458 (United States); Burris, Thomas P., E-mail: burristp@slu.edu [Department of Pharmacological & Physiological Science, Saint Louis University School of Medicine, St. Louis, MO 63104 (United States)

    2015-05-08

    The nuclear receptors for heme, REV-ERBα and REV-ERBβ, play important roles in the regulation of metabolism and inflammation. Recently it was demonstrated that reduced REV-ERBα expression in hematopoetic cells in LDL receptor null mice led to increased atherosclerosis. We sought to determine if synthetic REV-ERB agonists that we have developed might have the ability to suppress atherosclerosis in this model. A previously characterized synthetic REV-ERB agonist, SR9009, was used to determine if activation of REV-ERB activity would affect atherosclerosis in LDL receptor deficient mice. Atherosclerotic plaque size was significantly reduced (p < 0.05) in mice administered SR9009 (100 mg/kg) for seven weeks compared to control mice (n = 10 per group). SR9009 treatment of bone marrow-derived mouse macrophages (BMDM) reduced the polarization of BMDMs to proinflammatory M1 macrophage while increasing the polarization of BMDMs to anti-inflammatory M2 macrophages. Our results suggest that pharmacological targeting of REV-ERBs may be a viable therapeutic option for treatment of atherosclerosis. - Highlights: • Synthetic REV-ERB agonist treatment reduced atherosclerosis in a mouse model. • Pharmacological activation of REV-ERB decreased M1 macrophage polarization. • Pharmacological activation of REV-ERB increased M2 macrophage polarization.

  18. RIP3-dependent necrosis induced inflammation exacerbates atherosclerosis

    International Nuclear Information System (INIS)

    Meng, Lingjun; Jin, Wei; Wang, Yuhui; Huang, Huanwei; Li, Jia; Zhang, Cai

    2016-01-01

    Atherothrombotic vascular disease is already the leading cause of mortality worldwide. Atherosclerosis shares features with diseases caused by chronic inflammation. More attention should concentrates on the innate immunity effect atherosclerosis progress. RIP3 (receptor-interacting protein kinase 3) act through the transcription factor named Nr4a3 (Nuclear orphan receptors) to regulate cytokine production. Deletion RIP3 decreases IL-1α production. Injection of anti-IL-1α antibody protects against the progress of atherosclerosis in ApoE −/− mice. RIP3 as a molecular switch in necrosis, controls macrophage necrotic death caused inflammation. Inhibiting necrosis will certainly reduce atherosclerosis through limit inflammation. Necrotic cell death caused systemic inflammation exacerbated cardiovascular disease. Inhibition of necrosis may yield novel therapeutic targets for treatment in years to come. - Highlights: • RIP3 regulate the Nr4a3 to control cytokine production. • Deletion RIP3 decreases IL-1a production. • Injection anti-IL-1a antibody protects against the progress of atherosclerosis. • RIP3 controls macrophage necrotic dead caused inflammation.

  19. 78 FR 53243 - Safety Zone; TriRock San Diego, San Diego Bay, San Diego, CA

    Science.gov (United States)

    2013-08-29

    ... this rule because the logistical details of the San Diego Bay triathlon swim were not finalized nor... September 22, 2013. (c) Definitions. The following definition applies to this section: Designated...

  20. Insulin decreases atherosclerosis by inducing endothelin receptor B expression

    DEFF Research Database (Denmark)

    Park, Kyoungmin; Mima, Akira; Li, Qian

    2016-01-01

    Endothelial cell (EC) insulin resistance and dysfunction, caused by diabetes, accelerates atherosclerosis. It is unknown whether specifically enhancing EC-targeted insulin action can decrease atherosclerosis in diabetes. Accordingly, overexpressing insulin receptor substrate-1 (IRS1...... induction of NO action, which increases endothelin receptor B (EDNRB) expression and intracellular [Ca(2+)]. Using the mice with knockin mutation of eNOS, which had Ser1176 mutated to alanine (AKI), deleting the only known mechanism for insulin to activate eNOS/NO pathway, we observed that IRS1...... overexpression in the endothelia of Aki/ApoE(-/-) mice significantly decreased atherosclerosis. Interestingly, endothelial EDNRB expression was selectively reduced in intima of arteries from diabetic patients and rodents. However, endothelial EDNRB expression was upregulated by insulin via P13K/Akt pathway...

  1. Redox balance and blood elemental levels in atherosclerosis

    Energy Technology Data Exchange (ETDEWEB)

    Napoleao, P. [Centro de Biologia Ambiental and Departamento de Biologia Animal, Faculdade de Ciencias de Lisboa, C2, Campo Grande, 1749-016 Lisbon (Portugal) and Laboratorio de Feixes de Ioes, Instituto Tecnologico e Nuclear, E.N. no 10, 2685-953 Sacavem (Portugal)]. E-mail: pnapoleao@itn.pt; Lopes, P.A. [Centro de Biologia Ambiental and Departamento de Biologia Animal, Faculdade de Ciencias de Lisboa, C2, Campo Grande, 1749-016 Lisbon (Portugal); Santos, M. [Centro de Quimica e Bioquimica and Departamento de Quimica e Bioquimica, Faculdade de Ciencias de Lisboa, 1749-016 Lisbon (Portugal); Steghens, J.-P. [Federation de Biochimie, Hopital Edouard Herriot, 3 Place d' Arsonval, 69437 03 Lyon (France); Viegas-Crespo, A.M. [Centro de Biologia Ambiental and Departamento de Biologia Animal, Faculdade de Ciencias de Lisboa, C2, Campo Grande, 1749-016 Lisbon (Portugal); Pinheiro, T. [Laboratorio de Feixes de Ioes, Instituto Tecnologico e Nuclear, E.N. no 10, 2685-953 Sacavem (Portugal); Centro de Fisica Nuclear, Universidade de Lisboa, Av. Prof. Egas Moniz, 1700 Lisbon (Portugal)

    2006-08-15

    Oxidation of lipids and proteins represents a causative event for atherogenesis, which can be opposed by antioxidant activity. Elements, such as, Fe, Cu, Zn and Se can be involved in both mechanisms. Thus, evaluation of blood elemental levels, easily detected by PIXE, and of redox parameters may be useful in assessing the risk of atherosclerosis. A group of stable patients suffering from atherosclerosis, was matched with a cohort of normo-tensive and -lipidemic volunteers. Although no major discrepancies were observed for trace elemental levels in blood, increased concentrations of K and Ca were found in atherosclerotic group. Patients presented enhance levels of antioxidant ({alpha}-tocopherol) and decreased of protein oxidation (protein carbonyls), while for the lipid oxidation marker (malondialdehyde) no variation was observed. This study contributes to a better understanding of atherosclerosis development and its relationship with blood elemental levels, and set basis for further clinical trials with pathological groups in acute phase.

  2. Endogenous hydrogen sulfide is involved in the pathogenesis of atherosclerosis

    International Nuclear Information System (INIS)

    Qiao, Wang; Chaoshu, Tang; Hongfang, Jin; Junbao, Du

    2010-01-01

    Atherosclerosis is a chronic, complex, and progressive pathological process in large and medium sized arteries. The exact mechanism of this process remains unclear. Hydrogen sulfide (H 2 S), a novel gasotransmitter, was confirmed as playing a major role in the pathogenesis of many cardiovascular diseases. It plays a role in vascular smooth muscle cell (VSMC) proliferation and apoptosis, participates in the progress of hyperhomocysteinemia (HHCY), inhibits atherogenic modification of LDL, interferes with vascular calcification, intervenes with platelet function, and there are interactions between H 2 S and inflammatory processes. The role of H 2 S in atherosclerotic pathogenesis highlights the mysteries of atherosclerosis and inspires the search for innovative therapeutic strategies. Here, we review the studies to date that have considered the role of H 2 S in atherosclerosis.

  3. Atherosclerosis in familial lines of pigeons fed exogenous cholesterol.

    Science.gov (United States)

    Patton, N M; Brown, R V; Middleton, C C

    1975-01-01

    Exogenous cholesterol was fed to F1 pigeons of high and low serum cholesterol differentiated lines of White Carneau and Racing Homer pigeons that had previously been developed by selection and positive assortive mating. The serum cholesterol response of the various high and low lines was dependent upon the breed and the amount of cholesterol in the diet. Racing Homer pigeons were found to be more resistant to aortic atherosclerosis and more susceptible to coronary atherosclerosis than White Carneau pigeons. Data from necropsy examinations showed significant differences in both aortic and coronary atherosclerosis between lines within the White Carneau breed, but no differences between lines of the Racing Homer breed. Mean organ weights for the 4 lines of pigeons were reported.

  4. Macrophages and Their Role in Atherosclerosis: Pathophysiology and Transcriptome Analysis

    Directory of Open Access Journals (Sweden)

    Yuri V. Bobryshev

    2016-01-01

    Full Text Available Atherosclerosis can be regarded as a chronic inflammatory state, in which macrophages play different and important roles. Phagocytic proinflammatory cells populate growing atherosclerotic lesions, where they actively participate in cholesterol accumulation. Moreover, macrophages promote formation of complicated and unstable plaques by maintaining proinflammatory microenvironment. At the same time, anti-inflammatory macrophages contribute to tissue repair and remodelling and plaque stabilization. Macrophages therefore represent attractive targets for development of antiatherosclerotic therapy, which can aim to reduce monocyte recruitment to the lesion site, inhibit proinflammatory macrophages, or stimulate anti-inflammatory responses and cholesterol efflux. More studies are needed, however, to create a comprehensive classification of different macrophage phenotypes and to define their roles in the pathogenesis of atherosclerosis. In this review, we provide an overview of the current knowledge on macrophage diversity, activation, and plasticity in atherosclerosis and describe macrophage-based cellular tests for evaluation of potential antiatherosclerotic substances.

  5. Circumflex coronary artery with aberrant origin and atherosclerosis

    International Nuclear Information System (INIS)

    Ozcan, E.; Bozlar, U.; Celik, T.; Tasar, M.

    2012-01-01

    Full text: Introduction: Circumflex (Cx) coronary artery congenital anomaly is reported to be less than 1% incidence. Coronary arteries with aberrant origin are more likely to have atherosclerosis according to some published literatures. Objectives and tasks: In this study we aim to present computed tomography (CT) angiography findings of a patient, who has Cx artery with aberrant origin and atherosclerotic. Materials and methods: 57-year-old woman without any symptoms who has risk factors to atherosclerosis was referred to our clinic for coronary CT angiography. Results: In CT angiography; we detected Cx coronary artery with aberrant origin (right sinus of valsalva) and retroaortic course. Also we saw intimal irregularities and calcified plaque causing severe narrowing in the proximal segment of artery. Right coronary and left anterior descendant arteries had mild atherosclerosis. Conclusion: Coroner CT angiography, which allows multiplanar imaging with high resolution, is an effective diagnostic tool for coronary artery disease, like not only congenital anomalies but also acquired atherosclerotic disease

  6. Nanomedicine for the prevention, treatment and imaging of atherosclerosis.

    Science.gov (United States)

    Psarros, Costas; Lee, Regent; Margaritis, Marios; Antoniades, Charalambos

    2012-09-01

    Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in developed countries, with an increasing prevalence due to an aging population. The pathology underpinning CVD is atherosclerosis, a chronic inflammatory state involving the arterial wall. Accumulation of low density lipoprotein (LDL) laden macrophages in the arterial wall and their subsequent transformation into foam cells lead to atherosclerotic plaque formation. Progression of atherosclerotic lesions may gradually lead to plaque related complications and clinically manifest as acute vascular syndromes including acute myocardial or cerebral ischemia. Nanotechnology offers emerging therapeutic strategies, which may have advantage overclassical treatments for atherosclerosis. In this review, we present the potential applications of nanotechnology toward prevention, identification and treatment of atherosclerosis. Copyright © 2012 Elsevier Inc. All rights reserved.

  7. Arterial scleroproteins in atherosclerosis and hypertension (Experimental studies)

    International Nuclear Information System (INIS)

    Yurukova, Ts.; Georgiev, P.

    1979-01-01

    The authors studied the neosynthesis of fiber protein (scleroproteins) in the aorta of rats with genetic hypertension and with experimental atherosclerosis following application of 3 H-proline and 3 H-lysine and subsequent determination of radioactivity of the collagen and elastic fractions of the aortic wall. There was a great increase in incorporation of labelled collagen and elastin precursors in the aorta of hypertensive and atherosclerotic animals, in comparison with the control rats - a manifestation of incresed ''de novo'' synthesis of fiber proteins in rats with these arterial diseases. Furthermore, the increased collagenosis dominated over that of elastogenesis. The irregular activation of the biosynthesis of both scleroproteins in hypertensive rats and in rats with atherosclerosis caused remodelling of the macromolecular structure of the arterial wall with predominance of collagen over the remaining hypertension components and progression of atherosclerosis. (author) (author)

  8. Endothelial activation, endothelial dysfunction and premature atherosclerosis in systemic autoimmune diseases

    NARCIS (Netherlands)

    Bijl, M

    Atherosclerosis may be considered an inflammatory disease characterised by the development of atherosclerotic plaques and ischaemic cardiovascular events. Increased prevalence of cardiovascular morbidity and mortality due to (premature) atherosclerosis has been observed in patients with autoimmune

  9. Asymmetrical distribution of atherosclerosis in the carotid artery: identical patterns across age, race, and gender

    NARCIS (Netherlands)

    Tajik, Parvin; Meijer, Rudy; Duivenvoorden, Raphaël; Peters, Sanne A. E.; Kastelein, John J.; Visseren, Frank J.; Crouse, John R.; Palmer, Mike K.; Raichlen, Joel S.; Grobbee, Diederick E.; Bots, Michiel L.

    2012-01-01

    Background: Small autopsy studies and clinical practice indicated that carotid atherosclerosis develops in an asymmetrical helical pattern coinciding with regions of low shear stress. We investigated the distribution of carotid atherosclerosis as determined by maximum carotid intima-media thickness

  10. Torcetrapib does not reduce atherosclerosis beyond atorvastatin and induces more proinflammatory lesions than atorvastatin

    NARCIS (Netherlands)

    Haan, W. de; Vries-van der Weij, J. de; Hoorn, J.W.A. van der; Gautier, T.; Hoogt, C.C. van der; Westerterp, M.; Romijn, J.A.; Jukema, J.W.; Havekes, L.M.; Princen, H.M.G.; Rensen, P.C.N.

    2008-01-01

    BACKGROUND - Although cholesteryl ester transfer protein (CETP) inhibition is regarded as a promising strategy to reduce atherosclerosis by increasing high-density lipoprotein cholesterol, the CETP inhibitor torcetrapib given in addition to atorvastatin had no effect on atherosclerosis and even

  11. Torcetrapib does not reduce atherosclerosis beyond atorvastatin and induces more proinflammatory lesions than atorvastatin

    NARCIS (Netherlands)

    de Haan, Willeke; de Vries-van der Weij, Jitske; van der Hoorn, José W. A.; Gautier, Thomas; van der Hoogt, Caroline C.; Westerterp, Marit; Romijn, Johannes A.; Jukema, J. Wouter; Havekes, Louis M.; Princen, Hans M. G.; Rensen, Patrick C. N.

    2008-01-01

    Although cholesteryl ester transfer protein (CETP) inhibition is regarded as a promising strategy to reduce atherosclerosis by increasing high-density lipoprotein cholesterol, the CETP inhibitor torcetrapib given in addition to atorvastatin had no effect on atherosclerosis and even increased

  12. A pilot study into measurements of markers of atherosclerosis in periodontitis

    NARCIS (Netherlands)

    Leivadaros, E; van der Velden, U; Bizzarro, S; ten Heggeler, JMAG; Gerdes, VEA; Hoek, FJ; Nagy, TOM; Scholma, J; Bakker, SJL; Gans, ROB; ten Cate, H; Loos, BG

    Background: Periodontitis may be a possible risk factor for atherosclerosis. The current pilot study explored arterial wall thickness and other variables associated with atherosclerosis in healthy subjects with and without periodontitis. Methods: Patients with moderate (N = 34) and severe

  13. Petroleum and Oil Fuel Lines (Apra Harbor through Antonio B. Won Pat Intl Airport to Tanguisson Power Plant), Guam, 2016, US EPA Region 9

    Data.gov (United States)

    U.S. Environmental Protection Agency — This is a line feature dataset showing the track of petroleum and oil fuel lines that transport hazardous fluids from Apra Harbor through the Antonio B. Won Pat...

  14. Effect of uremia on HDL composition, vascular inflammation, and atherosclerosis in wild-type mice

    DEFF Research Database (Denmark)

    Bang, Christian A; Bro, Susanne; Bartels, Emil D

    2007-01-01

    Wild-type mice normally do not develop atherosclerosis, unless fed cholic acid. Uremia is proinflammatory and increases atherosclerosis 6- to 10-fold in apolipoprotein E-deficient mice. This study examined the effect of uremia on lipoproteins, vascular inflammation, and atherosclerosis in wild...... in cholic acid-fed sham mice. The results suggest that moderate uremia neither induces aortic inflammation nor atherosclerosis in C57BL/6J mice despite increased LDL/HDL cholesterol ratio and altered HDL composition....

  15. Increased YKL-40 expression in patients with carotid atherosclerosis

    DEFF Research Database (Denmark)

    Michelsen, Axel Gottlieb; Rathcke, C.N.; Skjelland, M.

    2010-01-01

    atherosclerosis and 20 healthy controls. Carotid expression of YKL-40 was examined by real time RT-PCR in 57 of the patients. Regulation and effect of YKL-40 were examined in THP-1 monocytes. Results: Our main findings were: (1) serum YKL-40 levels were significantly elevated in patients with carotid...... atherosclerosis, with particularly high levels in those with symptomatic disease; (2) patients with recent ischemic symptoms (within 2 months) had higher YKL-40 mRNA levels in carotid plaque than other patients; (3) in vitro, the beta-adrenergic receptor agonist isoproterenol, toll-like receptor (TLR) 2 and TLR4...

  16. Management of radiation-induced accelerated carotid atherosclerosis

    International Nuclear Information System (INIS)

    Loftus, C.M.; Biller, J.; Hart, M.N.; Cornell, S.H.; Hiratzka, L.F.

    1987-01-01

    Patients with long survival following cervical irradiation are at risk for accelerated carotid atherosclerosis. The neurologic presentation in these patients mimics naturally occurring atheromatous disease, but patients often present at younger ages and with less concurrent coronary or systemic vascular disease. Hypercholesterolemia also contributes to this accelerated arteriosclerosis. Angiographic findings in this disorder include disproportionate involvement of the distal common carotid artery and unusually long carotid lesions. Pathologic findings include destruction of the internal elastic lamina and replacement of the normal intima and media with fibrous tissue. This article describes two surgical patients with radiation-induced accelerated carotid atherosclerosis who typify the presentation and characteristics of this disease

  17. [¹⁸F]-fluorodeoxyglucose PET imaging of atherosclerosis

    DEFF Research Database (Denmark)

    Blomberg, Björn Alexander; Høilund-Carlsen, Poul Flemming

    2015-01-01

    [(18)F]-fluorodeoxyglucose PET ((18)FDG PET) imaging has emerged as a promising tool for assessment of atherosclerosis. By targeting atherosclerotic plaque glycolysis, a marker for plaque inflammation and hypoxia, (18)FDG PET can assess plaque vulnerability and potentially predict risk...... of atherosclerosis-related disease, such as stroke and myocardial infarction. With excellent reproducibility, (18)FDG PET can be a surrogate end point in clinical drug trials, improving trial efficiency. This article summarizes key findings in the literature, discusses limitations of (18)FDG PET imaging...

  18. Lutein and atherosclerosis: Belfast versus Toulouse revisited.

    Science.gov (United States)

    Howard, A N; Thurnham, D I

    2017-01-01

    have been due to the effects of concurrent high concentrations of plasma lutein on the immune system and complement in particular. Other carotenoids may exert similar antioxidant effects but we and others found no differences in antioxidant nutrients between subjects in Toulouse and Belfast or between subjects with asymptomatic markers of atherosclerosis and controls. Copyright © 2016 Elsevier Ltd. All rights reserved.

  19. O que é a Multidão? Questões para Michael Hardt e Antonio Negri

    Directory of Open Access Journals (Sweden)

    Nicholas Brown

    2006-07-01

    Full Text Available Multidão, livro mais recente de Michael Hardt e Antonio Negri, é uma tentativa de nomear e compreender as condições que envolvem a dinâmica social do século xxi. Na entrevista a seguir, Hardt e Negri discorrem sobre as possibilidades de constituição da multidão como agente político, discutem os fundamentos do livro e defendem conceitos que consideram determinantes para a compreensão dos novos tempos, tais como biopolítica e biopoder.Multitude, Michael Hardt and Antonio Negri’s latest book, is an attempt at understanding conditions involving social dynamics in the xxi century. In the interview below, Hardt and Negri consider the constitution of the multitude as a political agent, discuss the structure of their book and support concepts seen as crucial for the comprehension of our time, such as biopolitics and biopower.

  20. Targeting the adaptive immune system: new strategies in the treatment of atherosclerosis

    NARCIS (Netherlands)

    Zarzycka, Barbara; Nicolaes, Gerry A. F.; Lutgens, Esther

    2015-01-01

    Atherosclerosis is a lipid-driven chronic inflammatory disease of the arterial wall. Current treatment of atherosclerosis is focused on limiting its risk factors, such as hyperlipidemia or hypertension. However, treatments that target the inflammatory nature of atherosclerosis are still under

  1. Antonio Costa, La mela di Cézanne e l’accendino di Hitchcock. Il senso delle cose nei film

    Directory of Open Access Journals (Sweden)

    Beatrice Seligardi

    2016-05-01

    Full Text Available «Sono diecimila persone, forse, che non hanno dimenticato la mela di Cézanne ma sono un miliardo gli spettatori che si ricorderanno dell’accendino di Delitto per delitto» (5. Così Godard recitava all’interno delle Histoire(s du cinéma, e così si apre il saggio di Antonio Costa, prendendone spunto anche per il titolo.

  2. Antonio Scarpa y su obra Saggio di osservazioni e d’esperienze sulle principali malattie degli occhi

    Directory of Open Access Journals (Sweden)

    Rolando Neri-Vela

    2015-04-01

    Full Text Available Antonio Scarpa fue un gran anatomista y cirujano del siglo xviii y principios del xix. Llamado «padre de la oftalmología italiana», escribió el Saggio di osservazioni e d’esperienze sulle principali malattie degli occhi, libro de gran valor científico y artístico.Scarpa describió varias partes del cuerpo humano, que tienen su nombre.

  3. La Historia social de la cultura escrita. Una entrevista con Antonio Castillo Gómez

    Directory of Open Access Journals (Sweden)

    Cristiani Bereta da Silva

    2015-10-01

    Full Text Available Doctor en Historia, Antonio Castillo Gómezes Profesor Titular (acreditado como Catedrático de Historia de la Cultura Escrita en la Universidad de Alcalá. Antes de ser profesor de la Universidad, fue becario de investigación (1987-1990 y 1991-1995. Se puede decir que su interés por la Historia social de la cultura escrita comenzó a adquirir relevancia cuando  escribía su  tesis,  tiempo  en  el  que, cabe señalar, hizo sendas estancias de investigación en Italia con Armando Petruccien los años de 1989 y 1990 en Roma, enla Universidad “La Sapienza” (“Istituto di Paleografia”. Y como estudios posdoctorales en 1995, en Pisa, en la “Scuola Normale Superiore”, también con Armando Petrucci. En 2005 fue profesor invitado de la École des hautes études en sciences sociales de París a propuesta de Roger Chartier. Asimismo ha sido profesor invitado o conferenciante en distintas universidades extranjeras, especialmente de Italia, Portugal, Francia, Inglaterra, Finlandia, México, Argentina y Brasil.

  4. Transcultural and Imagological Figures: Disenchantment, Allophilia, and Belonging in Enrique Vila-Matas and Antonio Tabucchi

    Directory of Open Access Journals (Sweden)

    Maria João Simões

    2017-06-01

    Full Text Available In some contemporary literary works, the presence of the ‘other’ and the representation of the ‘foreigner’ emphasize the problematic ways by which human beings relate to foreign people, revealing how those issues are pressing concerns in modern society. This study questions how the shift in the way we perceive identity and belonging are depicted in Enrique Vila-Matas and Antonio Tabucchi’s fictions. Both authors aesthetically represent episodes and situations where characters’ relation to space is problematic, showing how the idea of belonging can be related not only to a specific country or a special space, but also to a desired space.  Furthermore, based  on the pregnancy of the notion of ‘dwelling’ theorized by Emmanuel Levinas, this study  analyses how characters and narrators aesthetically represent the complexity of belonging and examines some of the transnational transfers and multicultural connexions displayed by both autors, mainly in Never Any End to Paris and It’s Getting Later All the Time.

  5. Moderno/Posmoderno/Neomoderno: El jinete polaco, de Antonio Muñoz Molina

    Directory of Open Access Journals (Sweden)

    Marta Beatriz Ferrari

    2014-06-01

    Full Text Available Antonio Muñoz Molina (Úbeda, 1956 es ya, sin lugar a dudas, uno de los más destacados novelistas españoles contemporáneos. boga en la década que va de 1960 a 1970 al “realismo depurado” y al compromiso ético. La narrativa de Muñoz Molina apela constantemente a los cruces de códigos y al hacerlo va adoptando singulares modulaciones; itinerario que en su recorrido irá dando cuenta de un posicionamiento ideológico frente a los fenómenos derivados de la industria cultural –fenómenos camp y kitsch–, los géneros menores, la intertextualidad y lo intermedial. En esta curva, El jinete polaco significaría un punto de inflexión dentro de la producción narrativa del autor. En ella Muñoz Molina escribe una novela inspirada todavía en un motivo pictórico, pero abandona la astucia narrativa del final sorprendente y combina múltiples peripecias, historias cruzadas, diversos puntos de vista que apuntan a construir algo semejante a lo que Mario Vargas Llosa intuyó en Cien años de soledad de García Márquez, una “novela total”.

  6. Lectores retratados: Antonio Berni y las visualidades de lo impreso en la cultura argentina

    Directory of Open Access Journals (Sweden)

    Fernando Degiovanni

    2017-12-01

    Full Text Available La lectura es, a lo largo de los siglos XIX y XX, puesta obsesivamente en imágenes. En Argentina, el catálogo de pinturas y grabados de lectores resulta proliferante y disperso: estamos hablando de cientos, varios cientos de imágenes. El retrato de lectores es uno de los géneros con más continuidad dentro de las artes visuales modernas; se constituye en el Renacimiento (Stewart, 2006: 31-79, pero en el país cobra importancia central después de la Independencia. En el siglo XIX, artistas asentados en Buenos Aires como Adolphe D’Hastrel, Alphonse Femepin, Jean-Léon Pallière, Prilidiano Pueyrredón y Carlos Enrique Pellegrini trabajan una y otra vez el tema; en el siglo XX, nombres consagrados -desde Antonio Berni a Carlos Alonso- lo tratan sistemáticamente. Estas imágenes son tan potentes como lugar del deseo que en algunos artistas constituyen la figura decisiva de un modo del relato.

  7. Automation of Raw sugar Crystallizer tacho of Central Julio Antonio Mella

    Directory of Open Access Journals (Sweden)

    Mónica Mulet-Hing

    2016-04-01

    Full Text Available This paper treats about the analysis of the actual  situation and prospects for solutions that permit economical and efficient automation in the area of Tachos of Sugar Company Julio Antonio Mella, as part of the "Supervisory Control Systems", for the first level of automation in this industry, performing the proposed automation in the central area of cans by PLCs .This proposal arises from the need to improve the crystallization process tacho 5 of that area, since it has no automation, that is, everything is done manually, which will bring undoubtedly a quality improvement the final product. The structure and control system variables are defined, proving the feasibility of the proposed solution. The essential result of the work involves the submission of a proposal of automation that has the structure of a control algorithm, taking into account the requirements, technical resources for implementation, the variables that must be observed and processed, as well as elements of final action; the respective field instrumentation is proposed, to perform satisfactorily the control with the minimum possible investment.

  8. Antonio Banderas: Hispanic Gay Masculinities and the Global Mirror Stage (1991-2001

    Directory of Open Access Journals (Sweden)

    Joseba Gabilondo

    2006-01-01

    Full Text Available Here I map out the Atlantic intertwining between neo-liberal/neo-imperial Spain and cinema by analyzing Antonio Banderas's body politics as the postmodern (post- or neoimperialist Don Juan. Banderas's career trajectory from 1991 to 2001 coincides with larger political and historical developments. He arrived in Hollywood in the early 1990s, a moment when different but interconnected historical events came together— the end of the Cold War and the neo-liberal globalization of the United States with treaties such as NAFTA and GATT; the growing public profile of the fundamentalist religious right and gays; and the mainstream population's (unwilling acceptance of Latinos as a differentiated community. Hollywood needed a new kind of masculinity that gathered in all these new dimensions of United States identity while not completely shedding traditional Hollywood male typology, and Banderas fulfilled all the requirements. At the same time in Banderas Spain acquired a global card of presentation for its new neoimperialist and Atlantic pursuits in Latin America.

  9. La poesía objetual de Antonio Gómez

    Directory of Open Access Journals (Sweden)

    Felipe Muriel Durán

    2014-03-01

    Full Text Available Antonio Gómez hereda la estética surrealista a través del poeta catalán Joan Brossa. La mirada de Gómez aísla los objetos, los manipula y los reordena. Su objetivo es conmover y despertar en la mente del espectador una cadena de asociaciones. La obra de Gómez, recopilada hasta hoy en Made in Mérida (1993, Peccata minuta (2000, De acá para allá (2007, ofrece dos grupos de textos: los que reflexionan metapoéticamente sobre la creación y los que analizan críticamente temas como la Monarquía, la religión, el consumismo… Su poesía se define por el minimalismo. Sus materiales son los objetos humildes y los símbolos del Poder. El artículo contiene el análisis semiótico de más de una veintena de objetos poéticos.

  10. Las palabras ciegas: acercamiento a la poética de Antonio Gamoneda

    Directory of Open Access Journals (Sweden)

    María Pérez Heredia

    2017-08-01

    Full Text Available En este artículo se plantea la búsqueda de la poética de Antonio Gamoneda. Se trata de una poética que parte del dolor para buscar la luz, siempre centrándose en la reflexión metaliteraria. El poeta aprende a mirarse a sí mismo, en versos puramente introspectivos, para poder así mirar el mundo. Para exponer el hecho de que la lirica gamonediana es en sí misma metaliteraria, se parte del análisis de diversos poemas, que abarcan la mayor parte de la trayectoria poética del poeta. El silencio como elemento previo a la creación, expresado en la página en blanco, será fundamental, así como el hecho de nombrar, de dar nombre a las cosas. Gamoneda, a través de la contemplación de la adquisición del habla de su nieta Cecilia, explorará el poder creador de la palabra.

  11. The Song of Disappearance: Memory, History, and Testimony in the Poetry of Antonio Gamoneda

    Directory of Open Access Journals (Sweden)

    Daniel Aguirre-Oteiza

    2012-06-01

    Full Text Available This essay explores Antonio Gamoneda’s poetry as an Adornian form of testimony. With its enigmatic foregrounding of lies, the book-length poem Descripción de la mentira ‘Description of the Lie’ can be read as a “contradictory testimony” in which the act and memory of witnessing go, as it were, underground—only to resurface, rife with loss, years after Spain’s transition from dictatorship to democracy. Yet the abstruse character of this poetic writing prevents readers from drawing straightforward political truths about Spanish history from the poem. Losses are inscribed in the text catachrestically, as they truly are: losses. Gamoneda’s poetry has been read amid changing representations of Spain’s recent past, and thus contrastingly seen as an “undecipherable symbolic code” and as “realm of memory.” This reading, which draws on Holocaust studies, allows for a redefinition of the fraught place of modern poetry in the field of Hispanic cultural studies. Examining Descripción de la mentira within the context of the debate about historical memory in Spain sheds light on the theoretical difficulties that dominant aesthetic tendencies encounter in the study of how Spanish poets of recent decades try to establish a dialogue with the reader regarding society, memory, and reality.

  12. Antonio Gramsci: el consejo de fábrica, germen de la sociedad futura

    Directory of Open Access Journals (Sweden)

    Martín Prestía

    2015-06-01

    Full Text Available El propósito general del presente trabajo es realizar una reflexión y problematización en torno de la concepción de Antonio Gramsci del “consejo de fábrica” desde tres dimensiones que se vinculan orgánicamente: el consejo de fábrica en tanto forma político-organizativa; la problemática de la escisión entre hombre y ciudadano propia de la modernidad y la resolución que, a partir del consejo, es posible darle; y, por último, el consejo de fábrica como instancia a partir de la cual es posible construir un orden alternativo, prefigurando la sociedad de nuevo tipo. A modo de conclusión, se incluye una recapitulación de las principales claves interpretativas utilizadas en el análisis de los desarrollos gramscianos, a la vez que se propone la identificación de algunas tensiones hacia el interior de la propia argumentación del militante sardo.

  13. Memorial and biographical history of Spain: El jinete polaco by Antonio Muñoz Molina

    Directory of Open Access Journals (Sweden)

    Felipe Oliver Fuentes Kraffczyk

    2012-12-01

    Full Text Available The novel El jinete polaco by Antonio Muñoz Molina is a highly complex work in which the narrator mixes multiple plotlines in an effort to recreate or remember part of his family past. In the process, the collective memory of the town and people of Mágina (an allegoric space that represents the peasant life of the olive growers of southern Spain appears as a rich and contradictory montage of dreams and failures. And in a third level of discourse, the recent past of Spain also emerges through the main historic al events: the civil war, the protracted military government, and the economic development and current consolidation of democracy. In order to achieve this complex and ambitious narrative project, in El jinete polaco time is not represented as uninterrupted historical timeline but as the rich mixture of the simultaneous experiences of different life courses in terms of both values and cultural patterns in order to understand how the rapid social change affects relations between the various age groups. In other words, time is constructed as a synthesis of the biographical dimension within collective memory and major historical events. This paper seeks to point out the similarities and differences between biographical discourse, collective memory and history.

  14. Marketing San Juan Basin gas

    International Nuclear Information System (INIS)

    Posner, D.M.

    1988-01-01

    Marketing natural gas produced in the San Juan Basin of New Mexico and Colorado principally involves four gas pipeline companies with significant facilities in the basin. The system capacity, transportation rates, regulatory status, and market access of each of these companies is evaluated. Because of excess gas supplies available to these pipeline companies, producers can expect improved take levels and prices by selling gas directly to end users and utilities as opposed to selling gas to the pipelines for system supply. The complexities of transporting gas today suggest that the services of an independent gas marketing company may be beneficial to smaller producers with gas supplies in the San Juan Basin

  15. Update: San Andreas Fault experiment

    Science.gov (United States)

    Christodoulidis, D. C.; Smith, D. E.

    1984-01-01

    Satellite laser ranging techniques are used to monitor the broad motion of the tectonic plates comprising the San Andreas Fault System. The San Andreas Fault Experiment, (SAFE), has progressed through the upgrades made to laser system hardware and an improvement in the modeling capabilities of the spaceborne laser targets. Of special note is the launch of the Laser Geodynamic Satellite, LAGEOS spacecraft, NASA's only completely dedicated laser satellite in 1976. The results of plate motion projected into this 896 km measured line over the past eleven years are summarized and intercompared.

  16. Relationship Between Lifelong Exercise Volume and Coronary Atherosclerosis in Athletes

    NARCIS (Netherlands)

    Aengevaeren, Vincent L; Mosterd, Arend; Braber, Thijs L; Prakken, Niek H J; Doevendans, Pieter A; Grobbee, Diederick E; Thompson, Paul D; Eijsvogels, Thijs M H; Velthuis, Birgitta K

    2017-01-01

    BACKGROUND: Higher levels of physical activity are associated with a lower risk of cardiovascular events. Nevertheless, there is debate on the dose-esponse relationship of exercise and cardiovascular disease outcomes and whether high volumes of exercise may accelerate coronary atherosclerosis. We

  17. Insulin resistance and atherosclerosis : the role of visceral fat

    NARCIS (Netherlands)

    Gast, K.B.

    2016-01-01

    The main objective of this thesis was to unravel relationships between obesity, insulin resistance, hyperglycemia, and atherosclerosis. It is well-established that patients with type 2 diabetes have a 2- to 3-fold increased risk of cardiovascular disease. We investigated whether insulin resistance

  18. Oxidation of LDL and extent of peripheral atherosclerosis

    NARCIS (Netherlands)

    Vijver, L.P.L. van de; Kardinaal, A.F.M.; Duyvenvoorde, W. van; Kruijssen, D.A.C.M.; Grobbee, D.E.; Poppel, G. van; Princen, H.M.G.

    1999-01-01

    Evidence has accumulated for oxidative modification of low-density lipoproteins (LDL) to play an important role in the atherogenic process. Therefore, we investigated the relation between susceptibility of LDL to oxidation and risk of peripheral atherosclerosis among 249 men between 45 and 80 years

  19. Ageing induced vascular smooth muscle cell senescence in atherosclerosis.

    Science.gov (United States)

    Uryga, Anna K; Bennett, Martin R

    2016-04-15

    Atherosclerosis is a disease of ageing in that its incidence and prevalence increase with age. However, atherosclerosis is also associated with biological ageing, manifest by a number of typical hallmarks of ageing in the atherosclerotic plaque. Thus, accelerated biological ageing may be superimposed on the effects of chronological ageing in atherosclerosis. Tissue ageing is seen in all cells that comprise the plaque, but particularly in vascular smooth muscle cells (VSMCs). Hallmarks of ageing include evidence of cell senescence, DNA damage (including telomere attrition), mitochondrial dysfunction, a pro-inflammatory secretory phenotype, defects in proteostasis, epigenetic changes, deregulated nutrient sensing, and exhaustion of progenitor cells. In this model, initial damage to DNA (genomic, telomeric, mitochondrial and epigenetic changes) results in a number of cellular responses (cellular senescence, deregulated nutrient sensing and defects in proteostasis). Ultimately, ongoing damage and attempts at repair by continued proliferation overwhelm reparative capacity, causing loss of specialised cell functions, cell death and inflammation. This review summarises the evidence for accelerated biological ageing in atherosclerosis, the functional consequences of cell ageing on cells comprising the plaque, and the causal role that VSMC senescence plays in atherogenesis. © 2015 The Authors. The Journal of Physiology © 2015 The Physiological Society.

  20. Epigenetic pathways in macrophages emerge as novel targets in atherosclerosis

    NARCIS (Netherlands)

    Neele, Annette E.; van den Bossche, Jan; Hoeksema, Marten A.; de Winther, Menno P. J.

    2015-01-01

    Atherosclerosis is a lipid-driven chronic inflammatory disorder. Monocytes and macrophages are key immune cells in the development of disease and clinical outcome. It is becoming increasingly clear that epigenetic pathways govern many aspects of monocyte and macrophage differentiation and

  1. Inflammatory markers and extent and progression of early atherosclerosis

    DEFF Research Database (Denmark)

    Willeit, Peter; Thompson, Simon G; Agewall, Stefan

    2016-01-01

    BACKGROUND: Large-scale epidemiological evidence on the role of inflammation in early atherosclerosis, assessed by carotid ultrasound, is lacking. We aimed to quantify cross-sectional and longitudinal associations of inflammatory markers with common-carotid-artery intima-media thickness (CCA-IMT)...

  2. Genomic Analysis of Circulating Cells: A Window into Atherosclerosis

    Science.gov (United States)

    Kang, Ju-Gyeong; Patino, Willmar D.; Matoba, Satoaki; Hwang, Paul M.

    2006-01-01

    Translational studies using genomic techniques in cardiovascular diseases are still in their infancy. Access to disease-associated cardiovascular tissues from patients has been a major impediment to progress in contrast to the diagnostic advances made by oncologists using gene expression on readily available tumor samples. Nonetheless, progress is being made for atherosclerosis by carefully designed experiments using diseased tissue or surrogate specimens. This review details the rationale and findings of a study using freshly isolated blood mononuclear cells from patients undergoing carotid endarterectomy due to atherosclerotic stenosis and from matched normal subjects. Using this cardiovascular tissue surrogate, the mRNA levels of the Finkel-Biskis-Jinkins osteosarcoma (FOS) gene in circulating monocytes were found to correlate with atherosclerosis severity in patients, and with HMG CoA reductase inhibitor (statin) therapy in normal subjects. The major finding of this investigation is discussed in relation to observations from other human atherosclerosis gene expression studies. These distinct studies converge to demonstrate the unequivocal importance of inflammation in atherosclerosis. Although the clinical utility of the specific findings remains open, the identification of similar genes by different investigations serves to validate their reports. They also provide us with insights into pathogenesis that may impact future translational applications. PMID:16781950

  3. Increased LDL susceptibility to oxidation accelerates future carotid artery atherosclerosis

    Directory of Open Access Journals (Sweden)

    Aoki Toshinari

    2012-01-01

    Full Text Available Abstract Background We analyzed the causal relationship between LDL susceptibility to oxidation and the development of new carotid artery atherosclerosis over a period of 5 years. We previously described the determinants related to a risk of cardiovascular changes determined in a Japanese population participating in the Niigata Study, which is an ongoing epidemiological investigation of the prevention of cardiovascular diseases. Methods We selected 394 individuals (169 males and 225 females who underwent a second carotid artery ultrasonographic examination in 2001 - 2002 for the present study. The susceptibility of LDL to oxidation was determined as the photometric absorbance and electrophoretic mobility of samples that had been collected in 1996 - 1997. The measurements were compared with ultrasonographic findings obtained in 2001 - 2002. Results The multivariate-adjusted model showed that age (odds ratio (OR, 1.034; 95% confidence interval (95%CI, 1.010 - 1.059, HbA1c (OR, 1.477; 95%CI, 0.980 - 2.225, and photometric O/N (OR, 2.012; 95%CI, 1.000 - 4.051 were significant variables that could independently predict the risk of new carotid artery atherosclerosis. Conclusion The susceptibility of LDL to oxidation was a significant parameter that could predict new carotid artery atherosclerosis over a 5-year period, and higher susceptibility was associated with a higher incidence of new carotid artery atherosclerosis.

  4. Control of Atherosclerosis Regression by PRMT2 in Diabetes

    Science.gov (United States)

    2017-08-01

    Macrophage Dysfunction in Obesity , Diabetes and Atherosclerosis Time Commitment: 3.0 Cal Months Supporting Agency: NHLBI Grants Officer: John Diggs...Project Goals: This sub-project focuses on the kinetics of the macrophage population in atherosclerotic plaques in a mouse model of psychological

  5. Intra‑operative grading of coronary artery atherosclerosis associated ...

    African Journals Online (AJOL)

    Background: Atherosclerosis is one of the common causes of morbidity and mortality, in postmenopausal women. Homocysteine, a sulfur‑containing amino acid product of methionine metabolism, may play an important role in the development of cardiovascular diseases. This study was designed to evaluate the relationship ...

  6. Histomorphological features of atherosclerosis in the left anterior ...

    African Journals Online (AJOL)

    The pattern of coronary artery atherosclerosis is valuable in informing mitigation strategies for coronary heart disease. Histomorphological data on this disease among Africans living in Sub Saharan Africa are, however, scarce. The left anterior descending is one of the most commonly afflicted arteries. This study, therefore ...

  7. Atherosclerosis and Nutrition with Special Reference to Populations ...

    African Journals Online (AJOL)

    Severe atherosclerosis and its sequelae-coronary heart disease, cerebral vascular disease, and peripheral vascular disease-share major responsibility for half the mortality rate in affluent Western populations. In Africa, particularly South Africa, a study of the extent and severity of lesions is particularly interesting because of ...

  8. Atherosclerosis and Nutrition with Special Reference to Populations ...

    African Journals Online (AJOL)

    Severe atherosclerosis and its sequelae-coronary heart disease, cerebral ... the different population groups in various stages of tran- sition. ... 'These data show how emotional challenges may produce conspicuous .... and coronary arteries of White men. ... evidence of left ventricular hypertrophy, and glucose in- tolerance ...

  9. The role of risk factors in the development of atherosclerosis

    Czech Academy of Sciences Publication Activity Database

    Frohlich, J.; Dobiášová, Milada; Lear, S.; Lee, K. W. J.

    2001-01-01

    Roč. 38, č. 5 (2001), s. 401-440 ISSN 1040-8363 R&D Projects: GA ČR GV306/96/K220 Institutional research plan: CEZ:AV0Z5011922 Keywords : FERHDL * atherosclerosis * new/emerging risk factors Subject RIV: FA - Cardiovascular Diseases incl. Cardiotharic Surgery Impact factor: 3.931, year: 2001

  10. Human Low Density Lipoprotein as a Vehicle of Atherosclerosis ...

    African Journals Online (AJOL)

    Low-density lipoproteins have been sufficiently established as an important precursor of atherosclerosis. The actual mechanism is still unclear, and the current technique of using radioisotopes has clinical limitation. However, the current study techniques or methods excellently elucidate the functional aspects of ...

  11. Premature atherosclerosis after treatment for acute lymphoblastic leukemia in childhood

    Directory of Open Access Journals (Sweden)

    Elżbieta Sadurska

    2018-03-01

    Survivors of childhood ALL in the examined group demonstrated elevated concentrations of selected new biomarkers and increased IMT values, compared to controls, which may confirm the occurrence of endothelial injuries in blood vessels. This study indicates that subjects treated for childhood malignancy are at a higher risk of prematurely developing atherosclerosis.

  12. Vegetation - San Felipe Valley [ds172

    Data.gov (United States)

    California Natural Resource Agency — This Vegetation Map of the San Felipe Valley Wildlife Area in San Diego County, California is based on vegetation samples collected in the field in 2002 and 2005 and...

  13. San Francisco Bay Water Quality Improvement Fund

    Science.gov (United States)

    EPAs grant program to protect and restore San Francisco Bay. The San Francisco Bay Water Quality Improvement Fund (SFBWQIF) has invested in 58 projects along with 70 partners contributing to restore wetlands, water quality, and reduce polluted runoff.,

  14. The San Bernabe power substation; La subestacion San Bernabe

    Energy Technology Data Exchange (ETDEWEB)

    Chavez Sanudo, Andres D. [Luz y Fuerza del Centro, Mexico, D. F. (Mexico)

    1997-12-31

    The first planning studies that gave rise to the San Bernabe substation go back to year 1985. The main circumstance that supports this decision is the gradual restriction for electric power generation that has been suffering the Miguel Aleman Hydro System, until its complete disappearance, to give priority to the potable water supply through the Cutzamala pumping system, that feeds in an important way Mexico City and the State of Mexico. In this document the author describes the construction project of the San Bernabe Substation; mention is made of the technological experiences obtained during the construction and its geographical location is shown, as well as the one line diagram of the same [Espanol] Los primeros estudios de planeacion que dieron origen a la subestacion San Bernabe se remontan al ano de 1985. La circunstancia principal que soporta esta decision es la restriccion paulatina para generar energia que ha venido experimentando el Sistema Hidroelectrico Miguel Aleman, hasta su desaparicion total, para dar prioridad al suministro de agua potable por medio del sistema de bombeo Cutzamala, que alimenta en forma importante a la Ciudad de Mexico y al Estado de Mexico. En este documento el autor describe el proyecto de construccion de la subestacion San Bernabe; se mencionan las experiencias tecnologicas obtenidas durante su construccion y se ilustra su ubicacion geografica, asi como un diagrama unifilar de la misma

  15. The biology of atherosclerosis: general paradigms and distinct pathogenic mechanisms among HIV-infected patients.

    Science.gov (United States)

    Lo, Janet; Plutzky, Jorge

    2012-06-01

    Complications of atherosclerosis, including myocardial infarction and stroke, are the leading cause of death and disability worldwide. Recent data strongly implicate cardiovascular death as a contributor to mortality among patients with human immunodeficiency virus (HIV) infection, with evidence suggesting increased incidence of atherosclerosis among these patients. Therefore, greater understanding of atherosclerotic mechanisms and how these responses may be similar or distinct in HIV-infected patients is needed. Key concepts in atherosclerosis are reviewed, including the evidence that inflammation and abnormal metabolism are major drivers of atherosclerosis, and connected to the current literature regarding atherosclerosis in the context of HIV.

  16. 33 CFR 165.754 - Safety Zone: San Juan Harbor, San Juan, PR.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Safety Zone: San Juan Harbor, San Juan, PR. 165.754 Section 165.754 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND... Zone: San Juan Harbor, San Juan, PR. (a) Regulated area. A moving safety zone is established in the...

  17. 76 FR 45693 - Safety Zone; San Diego POPS Fireworks, San Diego, CA

    Science.gov (United States)

    2011-08-01

    ...-AA00 Safety Zone; San Diego POPS Fireworks, San Diego, CA AGENCY: Coast Guard, DHS. ACTION: Temporary... San Diego Bay in support of the San Diego POPS Fireworks. This safety zone is necessary to provide for... of the waterway during scheduled fireworks events. Persons and vessels will be prohibited from...

  18. Coronary atherosclerosis in medico-legal autopsy cases

    Directory of Open Access Journals (Sweden)

    VN Prasad

    2014-09-01

    Full Text Available Background: Coronary atherosclerosis is the major cause of death worldwide. Lifestyle and habits are the major contributory factor in the development of coronary atherosclerosis. Materials and Methods: This is an autopsy-based study in which 45 autopsy cases were randomly selected for study. Proximal one third of all three epicardial coronary arteries (LAD, LCX and RCA were dissected out for study and serial sections were made and stained with H&E method and under the light microscope. Atherosclerosis was graded according to American heart association classification. The risk factors (cigarette smoking, hypertension, diabetes, alcohol consumption, age, sex were also correlated with the grade of atherosclerosis. Results: Seventy-Eight percent of American Heart Association classification grade V lesions were seen in > 70 yrs of age. Almost all cases of > 70 yrs of age had American Heart Association classification grade > IV lesions. Out of all grade IV lesions, 88.9% was seen in male while only 11.1% in female. Similarly out of all grade V lesions, 77.8% was seen in male while 22.2% in female. LAD showed maximum involvement by higher grade lesion, followed by LCX and RCA. American Heart Association classification grade > IV in LAD, LCX and RCA was seen in 25(55.6%, 5(11.1%, and 3(6.7% cases respectively. Conclusion: Higher grade lesion occurs in advancing age. Various cardiovascular risk factors were significantly associated with higher grade of lesions. The multiple risk factors had a synergistic effect on the progression of coronary atherosclerosis. DOI: http://dx.doi.org/10.3126/jpn.v4i8.11492 Journal of Pathology of Nepal; Vol.4,No8(2014 607-611

  19. Improved animal models for testing gene therapy for atherosclerosis.

    Science.gov (United States)

    Du, Liang; Zhang, Jingwan; De Meyer, Guido R Y; Flynn, Rowan; Dichek, David A

    2014-04-01

    Gene therapy delivered to the blood vessel wall could augment current therapies for atherosclerosis, including systemic drug therapy and stenting. However, identification of clinically useful vectors and effective therapeutic transgenes remains at the preclinical stage. Identification of effective vectors and transgenes would be accelerated by availability of animal models that allow practical and expeditious testing of vessel-wall-directed gene therapy. Such models would include humanlike lesions that develop rapidly in vessels that are amenable to efficient gene delivery. Moreover, because human atherosclerosis develops in normal vessels, gene therapy that prevents atherosclerosis is most logically tested in relatively normal arteries. Similarly, gene therapy that causes atherosclerosis regression requires gene delivery to an existing lesion. Here we report development of three new rabbit models for testing vessel-wall-directed gene therapy that either prevents or reverses atherosclerosis. Carotid artery intimal lesions in these new models develop within 2-7 months after initiation of a high-fat diet and are 20-80 times larger than lesions in a model we described previously. Individual models allow generation of lesions that are relatively rich in either macrophages or smooth muscle cells, permitting testing of gene therapy strategies targeted at either cell type. Two of the models include gene delivery to essentially normal arteries and will be useful for identifying strategies that prevent lesion development. The third model generates lesions rapidly in vector-naïve animals and can be used for testing gene therapy that promotes lesion regression. These models are optimized for testing helper-dependent adenovirus (HDAd)-mediated gene therapy; however, they could be easily adapted for testing of other vectors or of different types of molecular therapies, delivered directly to the blood vessel wall. Our data also supports the promise of HDAd to deliver long

  20. Concept of Atherosclerosis Velocity: Is It a Better Measure of Cardiovascular Risk?

    Directory of Open Access Journals (Sweden)

    Seyyed Mohammad Reza Kazemi-Bajestani

    2013-09-01

    Full Text Available In most cases atherosclerosis is the underlying cause of vascular diseases, including heart disease and stroke. It is believed that endothelial injury is the earliest change in the artery wall and that this precedes the formation of lesions of atherosclerosis. Recent developments in the field of atherosclerosis have led to a renewed interest in the recognition of the parameter of time in the atherosclerosis process. We believe that the factors determining the time-dependent rate of atherosclerosis progression are important, and it is in this context that we wish to propose for the first time the term “atherosclerosis velocity”. In this review article, we summarize the existing evidence regarding atherosclerosis velocity and discuss the importance of this issue.

  1. Hydrogeology, chemical characteristics, and water sources and pathways in the zone of contribution of a public-supply well in San Antonio, Texas

    Science.gov (United States)

    Musgrove, MaryLynn; Fahlquist, Lynne; Stanton, Gregory P.; Houston, Natalie A.; Lindgren, Richard J.

    2011-01-01

    In 2001, the National Water-Quality Assessment (NAWQA) Program of the U.S. Geological Survey initiated a series of studies on the transport of anthropogenic and natural contaminants (TANC) to public-supply wells (PSWs). The main goal of the TANC project was to better understand the source, transport, and receptor factors that control contaminant movement to PSWs in representative aquifers of the United States. Regional- and local-scale study areas were selected from within existing NAWQA study units, including the south-central Texas Edwards aquifer. The local-scale TANC study area, nested within the regional-scale NAWQA study area, is representative of the regional Edwards aquifer. The PSW selected for study is within a well field of six production wells. Although a single PSW was initially selected, because of constraints of well-field operation, samples were collected from different wells within the well field for different components of the study. Data collected from all of the well-field wells were considered comparable because of similar well construction, hydrogeology, and geochemistry. An additional 38 PSWs (mostly completed in the confined part of the aquifer) were sampled throughout the regional aquifer to characterize water quality. Two monitoring well clusters, with wells completed at different depths, were installed to the east and west of the well field (the Zarzamora and Timberhill monitoring well clusters, respectively). One of the monitoring wells was completed in the overburden to evaluate potential hydrologic connectivity with the Edwards aquifer. Geophysical and flowmeter logs were collected from one of the well-field PSWs to determine zones of contribution to the wellbore. These contributing zones, associated with different hydrogeologic units, were used to select monitoring well completion depths and groundwater sample collection depths for depth-dependent sampling. Depth-dependent samples were collected from the PSW from three different depths and under three different pumping conditions. Additionally, selected monitoring wells and one of the well-field PSWs were sampled several times in response to a rainfall and recharge event to assess short-term (event-scale) temporal variations in water quality. For comparison purposes, groundwater samples were categorized as being from regional aquifer PSWs, from the well field (wellhead samples), from the monitoring wells (excluding the overburden well), from the overburden well, from the PSW depth-dependent sampling, and from temporal sampling. Groundwater samples were analyzed for inorganic, organic, isotopic, and age-dating tracers to characterize geochemical conditions in the aquifer and provide understanding of the mechanisms of mobilization and movement of selected constituents from source areas to a PSW. Sources, tracers, and conditions used to assess water quality and processes affecting the PSW and the aquifer system included (1) carbonate host rock composition; (2) physicochemical constituents; (3) major and trace element concentrations; (4) saturation indices with respect to minerals in aquifer rocks; (5) elemental ratios, such as magnesium to calcium ratios, that are indicative of water-rock interaction processes; (6) oxidation-reduction conditions; (7) nutrient concentrations, in particular nitrate concentrations; (8) the isotopic composition of nitrate, which can point to specific nitrate sources; (9) strontium isotopes; (10) stable isotopes of hydrogen and oxygen; (11) organic contaminant concentrations, including pesticides and volatile organic compounds; (12) age tracers, apparent-age distribution, and dissolved gas data used in age interpretations; (13) depth-dependent water chemistry collected from the PSW under different pumping conditions to assess zones of contribution; and (14) temporal variability in groundwater composition from the PSW and selected monitoring wells in response to an aquifer recharge event. Geochemical results indicate that the well-field and monitoring well samples were largely representative of groundwater in the regional confined aquifer. Constituents of concern in the Edwards aquifer for the long-term sustainability of the groundwater resource include the nutrient nitrate and anthropogenic organic contaminants. Nitrate concentrations (as nitrogen) for regional aquifer PSWs had a median value of 1.9 milligrams per liter, which is similar to previously reported values for the regional aquifer. Nitrate-isotope compositions for groundwater samples collected from the well-field PSWs and monitoring wells had a narrow range, with values indicative of natural soil organic values. A comparison with historical nitrate-isotope values, however, suggests that a component of nitrate in groundwater from biogenic sources might have increased over the last 30 years. Several organic contaminants (the pesticide atrazine, its degradate deethylatrazine, trichloromethane (chloroform; a drinking-water disinfection byproduct), and the solvent tetrachloroethene (PCE)) were widely distributed throughout the regional aquifer and in the local-scale TANC study area at low concentrations (less than 1 microgram per liter). Higher concentrations of PCE were detected in samples from the well-field PSWs and Zarzamora monitoring wells relative to the regional aquifer PSWs. The urban environment is a likely source of contaminants to the aquifer, and these results indicate that one or more local urban sources might be supplying PCE to the Zarzamora monitoring wells and the well-field wells. Samples from the well field also had high concentrations of chloroform relative to the monitoring wells and regional aquifer PSWs. For samples from the regional aquifer PSWs, the most frequently detected organic contaminants generally decreased in concentration with increasing well depth. Deeper wells might intercept longer regional flow paths with higher fractions of older water or water recharged in rural recharge areas in the western part of the aquifer that have been less affected by anthropogenic contaminants. A scenario of hypothetical contaminant loading was evaluated by using results from groundwater-flow-model particle tracking to assess the response of the aquifer to potential contamination. Results indicate that the aquifer responds quickly (less than 1 year to several years) to contaminant loading; however, it takes a relatively long time (decades) for concentrations to reach peak values. The aquifer also responds quickly (less than 1 year to several years) to the removal of contaminant loading; however, it also takes a relatively long time (decades) to reach near background concentrations. Interpretation of geochemical age tracers in this well-mixed karst system was complicated by contamination of a majority of measured tracers and complexities of extensive mixing. Age-tracer results generally indicated that groundwater samples were composed of young, recently recharged water with piston-flow model ages ranging from less than 1 to 41 years, with a median of 17 years. Although a piston-flow model is typically not valid for karst aquifers, the model ages provide a basis for comparing relative ages of different samples and a reference point for more complex hydrogeologic models for apparent-age interpretations. Young groundwater ages are consistent with particle-tracking results from hydrogeologic modeling for the local-scale TANC study area. Age-tracer results compared poorly with other geochemical indicators of groundwater residence time and anthropogenic effects on water quality, indicating that hydrogeologic conceptual models used in groundwater age interpretations might not adequately account for mixing in this karst system. Groundwater samples collected from the well field under a variety of pumping conditions were relatively homogeneous and well mixed for numerous geochemical constituents (with the notable exception of age tracers). Groundwater contributions to the PSW were dominated by well-mixed, relatively homogeneous groundwater, typical of the regional confined aquifer. Zones of preferential flow were determined for the PSW, but groundwater samples from different stratigraphic units were not geochemically distinct. Variations in chemical constituents in response to a rainfall and aquifer recharge event occurred but were relatively minor in the PSW and monitoring wells. This observation is consistent with the hypothesis that the response to individual recharge events in the confined aquifer, unless intersecting conduit flow paths, might be attenuated by mixing processes along regional flow paths. Results of this study are consistent with the existing conceptual understanding of aquifer processes in this karst system and are useful for water-resource development and management practices.

  2. Archaeological Investigations on the San Antonio Terrace, Vandenberg Air Force Base, California, in Connection with MX Facilities Construction. Appendix II. Historical Overview of the Study Area.

    Science.gov (United States)

    1984-01-01

    who took on the values of the Mexican culture. Yet, as opportunities expanded under American rule, he displayed entrepreneurship and the know-how that...completed it extended 250 feet out into the ocean (Deeds B-280; 0-542). Lompoc Landing operated under a franchise granted by the County Board of

  3. Proceedings of the Annual DARPA/AFGL Seismic Research Symposium (11th) Held in San Antonio, Texas on 2-4 May 1989

    Science.gov (United States)

    1990-11-06

    Mokhtar, T. A., R. B. Herrmann, and D. R. Russell (1988). Seismic velocity and Q model for the shallow structure of the Arabian shield from short...edge of the Tibetan plateau and have thicknesses that range from 43-49 km. Kono (1974) examined the Bouguer gravity in eastern Nepal and found that the...8217.-.- -- - .~~ ~ ~ .. ..... . 37 7 30L𔃻 iD7. 115 37 30 0 500G 10000 15000 20000 16 7 METERS PRWVf )F MCPLj.NV BOUGUER ORRVITY 12000 KG/1i,31 Figure 1. The Bouguer

  4. Sanción por emisión de liquidaciones de compras y servicios caso Universidad Tecnológica San Antonio de Machala periodo 2006

    OpenAIRE

    Guerrero Loaiza, Silvana Gardenia

    2016-01-01

    Los tributos se originan como un elemento de búsqueda de nuevos ingresos. Fueron efectuados por los estados para invertir en la satisfacción de las necesidades públicas. En este sentido se puede indicar que los primeros patrimonios tributarios fueron aquellos que el estado conquistó mediante el ejercicio de su mando imperial o a través de prácticas que luego se bautizaron en leyes, en la Roma antigua. Durante la segunda mitad del siglo XIX, no existieron demasiados impuestos en el medio, lo q...

  5. Proceedings of the Current Trends in Army Medical Department Psychology Held at San Antonio, Texas on 8-12 November 1976.

    Science.gov (United States)

    1976-12-01

    program and/or begin training in family evaluations. A third option is Play Therapy . a. The Dreikur’s parent training program requires the trainee to...option at Level II, Play Therapy , requires the trainee to learn and implement the principles of play therapy necessary to help the child (1) identify, (2...label, and (3) appropriately express his feelings, The trainee must demonstrate mastery of these skills with at least two children. Mastery of play

  6. Minutes of the Explosive Safety Seminar (18th) Held at San Antonio, Texas on 12-14 September 1978. Volume 2

    Science.gov (United States)

    1978-09-14

    1975), "The Characterization and Evaluation of Accidental Explosions," NASA CR-134779, Grant NSG 3008, June 1975. 3. Strehlow, P. A. and Baker, W. E...of Blast Waves from Bursting Pressurized Frangible Spheres," NASA CR-2843, Grant NSG 3008, May 1977. 9. Boyer, W. D., Brode, H. L., Glass, I. I...applications during the past years. Less than two decades ago, the first futuristic FRP house was unveiled at Disneyland , CA. Today the FRP industry

  7. Archaeological Investigations of the San Antonio Terrace, Vandenberg Air Force Base, California, in Connection with MX Facilities Construction. Appendix I. Ethnohistoric Background.

    Science.gov (United States)

    1984-01-01

    is necessary to reveal a sufficient number of words possessing identical roots to render their common parentage obvious [ Heizer 1955:861. Fages did not...placenames. On file, National Archives, Smithsonian Institution. Washington D.C. Heizer , Robert F. (Ed.) 1955 California Indian Linguistic Records: The

  8. Analysis of data from test-well sites along the downdip limit of freshwater in the Edwards Aquifer, San Antonio, Texas, 1985-87

    Science.gov (United States)

    Groschen, G.E.

    1994-01-01

    Many researchers have studied the downdip limit of freshwater in the Edwards aquifer or various aspects of the saline-water zone and its relation to the freshwater zone. These studies were summarized and used to synthesize a consistent hydrologic and geochemical framework from which to interpret data from field studies. The concept derived from the previous work on the downdip limit of the freshwater zone is that fresh recharge water entered the aquifer and developed a vast flow system controlled by barrier faults. Some recharge water flows into the saline-water zone rather than toward major freshwater discharge points. The water that enters the salinewater zone continues to dissolve gypsum and dolomite, and calcite precipitates out of the water. This process of dedolomitization has helped to develop the large secondary porosity of the freshwater zone as the downdip limit of the freshwater zone progressively moved downdip in recent geologic time.

  9. Proceedings: Annual Conference of the Military Testing Association (24th) Held at San Antonio, Texas on 1-5 November 1982

    Science.gov (United States)

    1983-03-25

    process in acqufsitTon. In E.T. Bilodeau & 1. McD . Bilodeau (Eds.). Principles of skill acquisition. New York: Academic Press, 1969, 141-170. Jones, M. B...revised to include questions on advertising and more questions on motives and economic incentives. Separate forms of the revised survey for active duty...by coloured layer- ing and, as an aid to intervisibility, valleys and ridges are highlighted by coloured lines. Around this map sit the commanders of

  10. Impact of demand of a social tourism in the sustainability of the activity in the locality of El Quisco, Province of San Antonio - Chile

    Directory of Open Access Journals (Sweden)

    Belfor Fernando Portal Valenzuela

    2013-08-01

    Full Text Available Every summer Chile’s Central Coast undergoes the effects of social tourism, as a vast number of low-income visitors arrive from Chile’s most densely populated areas in the Central Zone. Despite congestion and saturation of available touristic resources, the number of visitors increases every year, contravening classic touristic demand models that define migration to less congested resources as the outcome of congestion. This analysis will be focused on El Quisco beach, located at Valparaiso’s Region, a touristic destination that clearly represents this process of mass tourism socialization. The goal of this research is to understand the demand composition that social tourism generates, by determining its nature and identifying the factors that define its behavior. These factors are related to the visitor’s origin, displacement, permanence, loyalty, social bonds, gender, income, consumption capacity, and to the degree of satisfaction regarding touristic supplies such as beaches, equipment, and infrastructure. Understanding this demand behavior it is key to develop policies enabling the planning of sustainable social tourism, and allowing for low-income families to access high-quality resources.

  11. Percepciones e interpretaciones de la población, de la Parroquia de San Antonio de Pichincha, respecto a la contaminación ambiental

    OpenAIRE

    Hidalgo Mantilla, Dinora

    2008-01-01

    En la actualidad, los problemas ambientales, son uno de los aspectos a los que se les está poniendo mucha atención, tanto a nivel global como a nivel local, basta con mirar la televisión o leer la prensa, para darnos cuenta que estos problemas ambientales son una realidad, como también es una realidad el deseo de disminuir o detener el deterioro ambiental; la prioridad en ser tratados, se debe a que el ser humano siente cada vez más los efectos de la alteración del clima, el ex...

  12. Proceedings of the Intelligent Tutoring Systems Research Forum (2nd) Held in San Antonio, Texas on 6-7 April 1989

    Science.gov (United States)

    1990-04-01

    mechanics, electric circuit schematics, chemical bond diagrams. etc. 40 J. Bonar While the representation is not the domain, per se. effective use and deep...faster and more neatly than by hand; " a "dumb" case browser, callable from the homework helper, for scanning a case library of weather situations and...forecasts; " a "smart’ case retriever, callable from the homework helper, capable of retrieving weather situations similar to the current exercise

  13. Efectos secundarios del implante etonogestrel en mujeres en edad fértil atendidas en el Subcentro de San Antonio, 2014

    Directory of Open Access Journals (Sweden)

    Maritza Marisol Álvarez Moreno

    2017-05-01

    Full Text Available Introducción. El Implante de Etonogestrel es un método anticonceptivo, que ofrece a las usuarias alta eficacia anticonceptiva del 99%, en un periodo de tres años; es seguro, cómodo y accesible. Los efectos secundarios que se describen son: irregularidades del ciclo menstrual, cefalea, náuseas, aumento de peso; siendo estos la razón para no continuar utilizando este método anticonceptivo. Objetivo. Identificar los efectos secundarios del Implante de Etonogestrel, usado como método anticonceptivo seleccionado en mujeres en edad fértil. Material y Método. Este es un estudio de; revisión documentada, de campo, cualicuantitativo, retrospectivo y transversal. La muestra es de 112 usuarias. A 60 usuarias se les aplico una encuesta validada, así como a los profesionales que laboran en la unidad, con la finalidad de identificar como se brinda la consejería respecto a este dispositivo. Conclusión. Las características de las usuarias que fueron incluidas en nuestro estudio, no influyen significativamente en la percepción de efectos secundarios, no se puede identificar que la aparición de los efectos como son: irregularidades en el ciclo menstrual, cefalea, aumento de peso, irritabilidad, náuseas y disminución del libido, además se plantea la importancia de la atención a controles subsecuentes en donde la misma no se está aplicando.

  14. Community-acquired necrotizing pneumonia caused by methicillin-resistant Staphylococcus aureus ST30-SCCmecIVc-spat019-PVL positive in San Antonio de Areco, Argentina

    Directory of Open Access Journals (Sweden)

    Silvina Fernández

    2015-03-01

    Full Text Available Community-acquired methicillin-resistant Staphylococcus aureus is the first cause of skin and soft tissue infections, but can also produce severe diseases such as bacteremia, osteomyelitis and necrotizing pneumonia. Some S. aureus lineages have been described in cases of necrotizing pneumonia worldwide, usually in young, previously healthy patients. In this work, we describe a fatal case of necrotizing pneumonia due to community-acquired methicillin-resistant S. aureus clone ST30-SCCmecIVc-spat019-PVL positive in an immunocompetent adult patient.

  15. Proceedings of Users’ Workshop on Combat Stress (6th) Held in San Antonio, Texas, on 30 November-4 December 1987

    Science.gov (United States)

    1988-08-01

    drinkingi B. Differential Diagnosis: Possible alcohol withdrawal and impending DTs. Possible ulcer disease, gastritis, esophageal reflux , etc. A thorough...vasoconstriction, sweating, increased gastro -intestinal motility), musculoskeletal (increased tonicity and perfusion of blood to muscle) and glandular changes

  16. Proceedings of the NASTRAN (Tradename) Users’ Colloquium (17th) Held in San Antonio, Texas on 24-28 April 1989

    Science.gov (United States)

    1989-03-01

    11111 w- u EL4 ww L U) Z: 000 wX ?w Q-1 DIwW w: CcLLJ 0 123A mi CF) Vi L’- W rI- ( - Cr) 00 C (U )rui or ) (w 63 (T) 0~ - - I-- ~ 0 r- v-co 0 (U- (r...transient analysis involving uncoupled modal equations, NASTRAN Demonstration Problem No. D12-01-1A (Transient Analysis of a Free One Hundred Cell ... cells which can be rotated through an angle by application of an electrostatic field. The field is generated by electronics intec "al to the chip

  17. Comunicación asertiva en la construcción del pensamiento crítico. Experiencia con estudiantes de grado sexto en San Antonio Norte

    OpenAIRE

    Rivera Sanabria, Margoth

    2017-01-01

    Este proyecto está inscrito en la línea de investigación en Didácticas de las Ciencias Sociales, así mismo en el macro proyecto de pensamiento Social-crítico para la comprensión, interpretación y transformación del conocimiento escolar en contextos socio-culturales e históricos. Los derroteros de este proyecto fueron potenciar las habilidades para la vida que les permitan fortalecer las destrezas psicosociales necesarias a los jóvenes del grado sexto para la construcción de procesos personale...

  18. Proceedings User’s Stress Workshop (7th) Held in San Antonio, Texas on December 10-15, 1989: Training for Psychic Trauma

    Science.gov (United States)

    1990-12-01

    Psychiatry, 142, 303-307. Kolb, L. C. (1987). A neuropsychological hypothesis explaining posttraumatic stress disorders. American Journal of Psychiatry, 144...more readily with the aid of skillfully focused psychological tests which measure neuropsychological , mental and emotional functioning. Differential...debilitating (but not inherently harmful) physiologic stressors like sleep loss, hunger , discomfort. It also included mental stressors like perceived danger

  19. Proceedings of the US Army Institute of Surgical Research Anniversary Symposium (40th), Held in San Antonio, Texas on October 26-27, 1987

    Science.gov (United States)

    1989-10-01

    nervous system neuronal populations, and definition of the effects of burn injury on zinc metabolism. In addition to the specific research projects, DL...hepatic gluconeogenesis is accelerated, providing essential fuel for reparative and inflammatory tissues to optimize host defenses and ensure wound repair...appearance of ectopic supraependymal neurons in the third ventricle just above the medial basal hypothalamus (15). Just as this resetting is

  20. Frontiers of Karst Research: Proceedings and recommendations of the workshop held in San Antonio, Texas on 3-5 May 2007. Karst Waters Institute Special Publication 13

    Science.gov (United States)

    2009-01-08

    L., Gon- zalez, I., and Saiz-Jimenez, C., 1999, Microbial communities associated with hydromagnesite and needle- fiber aragonite de- posits in a...Gonzalez, J.M., and Saiz-Jimenez, C., 2006, On the origin of fiber calcite crystals in moonmilk deposits: Naturwissen- schaften, v. 93, p. 27-32...Geomi- crobiology of carbonate-silicate microbalites from Hawaiian basaltic sea caves: Chemical Geology, v. 169, p. 339-355. Macalady, J.L., Jones, D.S

  1. Community-acquired necrotizing pneumonia caused by methicillin-resistant Staphylococcus aureus ST30-SCCmecIVc-spat019-PVL positive in San Antonio de Areco, Argentina.

    Science.gov (United States)

    Fernandez, Silvina; Murzicato, Sofía; Sandoval, Orlando; Fernández-Canigia, Liliana; Mollerach, Marta

    2015-01-01

    Community-acquired methicillin-resistant Staphylococcus aureus is the first cause of skin and soft tissue infections, but can also produce severe diseases such as bacteremia, osteomyelitis and necrotizing pneumonia. Some S. aureus lineages have been described in cases of necrotizing pneumonia worldwide, usually in young, previously healthy patients. In this work, we describe a fatal case of necrotizing pneumonia due to community-acquired methicillin-resistant S. aureus clone ST30-SCCmecIVc-spat019-PVL positive in an immunocompetent adult patient. Copyright © 2014 Asociación Argentina de Microbiología. Publicado por Elsevier España, S.L.U. All rights reserved.

  2. ASTER Flyby of San Francisco

    Science.gov (United States)

    2002-01-01

    The Advanced Spaceborne Thermal Emission and Reflection radiometer, ASTER, is an international project: the instrument was supplied by Japan's Ministry of International Trade and Industry. A joint US/Japan science team developed algorithms for science data products, and is validating instrument performance. With its 14 spectral bands, extremely high spatial resolution, and 15 meter along-track stereo capability, ASTER is the zoom lens of the Terra satellite. The primary mission goals are to characterize the Earth's surface; and to monitor dynamic events and processes that influence habitability at human scales. ASTER's monitoring and mapping capabilities are illustrated by this series of images of the San Francisco area. The visible and near infrared image reveals suspended sediment in the bays, vegetation health, and details of the urban environment. Flying over San Francisco (3.2MB) (high-res (18.3MB)), we see the downtown, and shadows of the large buildings. Past the Golden Gate Bridge and Alcatraz Island, we cross San Pablo Bay and enter Suisun Bay. Turning south, we fly over the Berkeley and Oakland Hills. Large salt evaporation ponds come into view at the south end of San Francisco Bay. We turn northward, and approach San Francisco Airport. Rather than landing and ending our flight, we see this is as only the beginning of a 6 year mission to better understand the habitability of the world on which we live. For more information: ASTER images through Visible Earth ASTER Web Site Image courtesy of MITI, ERSDAC, JAROS, and the U.S./Japan ASTER Science Team

  3. Antonio María Barriga Villalba, El Multifacético

    Directory of Open Access Journals (Sweden)

    Pablo Gómez Martinez

    1986-12-01

    Full Text Available

    Esta sesión solemne que celebramos hoy, gracias a la obligante solicitud del cadémico Laurentino Muñoz, ha debido realizarse el año pasado, pero debido a múltiples inconvenientes y al congestionado calendario de las actividades de la Academia, ello no fue posible, por lo cual rogamos a los oyentes se sirvan disimular la tardanza de esta celebración.

    Para la Academia Nacional de Medicina que ha conservado a través de los años una severa tradición de reconocimiento de los valores humanos, es especialmente grato rendir este homenaje de admiración a los ilustres hombres de ciencia que la honraron con sus ejecutorias ya los distinguidos miembros de la profesión médica que tuvieron su raigambre en ese maravilloso rincón de la patria: el departamento del Huila.

    Aprovechando esta ocasión, vamos a colocar en la galería de los presidentes, los retratos de dos ilustres académicos: del miembro honorario profesor Antonio María Barriga Villalba y el del miembro de número doctor Arturo Arboleda.

    El limitado tiempo de que dispongo, me impide hacer un relato detenido de la vida de Barriga Villalba, y un estudio crítico a fondo de su obra. Me limitaré con la venia de la audiencia, a destacar sólamente algunas realizaciones de sus actividades y de su dedicación a la docencia, pidiéndoles disculpas por las omisiones que pudieran tener estas pocas palabras.

    Nació en Bogotá el día 9 de junio de 1894. Contrajo matrimonio con doña Luisa Del Diestro de cuya unión hubo tres hijos: Luis, Antonio y Fernando. Murió este año a la edad cumplida de 91 años, rodeado del amor y cariño de los suyos.

    Hizo sus estudios secundarios en el Colegio Mayor de Nuestra Señora del Rosario, bajo la dirección del doctor Liborio Zerda, en donde recibió el título de bachiller. Por su dedicación, por sus dotes de inteligencia, fue nombrado colegial de número, posición reservada a muy pocos estudiantes sobresalientes del

  4. 78 FR 19103 - Safety Zone; Spanish Navy School Ship San Sebastian El Cano Escort; Bahia de San Juan; San Juan, PR

    Science.gov (United States)

    2013-03-29

    ...-AA00 Safety Zone; Spanish Navy School Ship San Sebastian El Cano Escort; Bahia de San Juan; San Juan... temporary moving safety zone on the waters of Bahia de San Juan during the transit of the Spanish Navy... Channel entrance, and to protect the high ranking officials on board the Spanish Navy School Ship San...

  5. [Chronic mild inflammation links obesity, metabolic syndrome, atherosclerosis and diabetes].

    Science.gov (United States)

    Andel, M; Polák, J; Kraml, P; Dlouhý, P; Stich, V

    2009-01-01

    Chronic low grade inflammation is relatively new concept in metabolic medicine. This concept describes the relations between the inflammation and adipose tissue, insulin resistence, atherosclerosis and type 2 diabetes mellitus. Macrophages and lymphocytes deposed in adipose tissue produce proinflammatory cytokines which directly or through the CRP liver secretion are targeting endothelial cells, hepatocytes and beta cells of Langerhans islets of pancreas. The dysfunction of these cells follows often further disturbances and in case of beta cells - the cell death. The connection between the adipose tissue insulin resistence, atherosclerosis and type 2 diabetes was earlier described with endocrine and metabolic descriptors. The concept of chronic low grade inflammation creates also another description of multilateral connections in metabolic syndome. The salicylates and the drugs related to them seem to have some glucose lowering properties. The recent development in the field ofchronic low grade inflammation represents also certain therapeutic hope for antiinflammatory intervention in type 2 diabetes.

  6. Académico Dr. Antonio Ucrós Cuéllar.

    Directory of Open Access Journals (Sweden)

    Zoilo Cuéllar-Montoya

    2005-09-01

    Fue fundador, en la década de los años 80, y Jefe durante varios años, del Servicio de Medicina Nuclear del Hospital de San José. Ocupó la Jefatura del Servicio de Endocrinología Pediátrica del Hospital Infantil “Lorencita Villegas de Santos”, en varias oportunidades, en el curso de la década de los años 70. Se distinguió con el nombramiento de Miembro Honorario de la Sociedad de Cirugía de Bogotá, de la cual fue Presidente...

  7. Platelets and their chemokines in atherosclerosis – clinical applications

    Directory of Open Access Journals (Sweden)

    Philipp evon Hundelshausen

    2014-08-01

    Full Text Available The concept of platelets as important players in the process of atherogenesis has become increasingly accepted due to accumulating experimental and clinical evidence. Despite the progress in understanding the molecular details of atherosclerosis, particularly by using animal models, the inflammatory and thrombotic roles of activated platelet s especially in the human system remain difficult to dissect, as often only the complications of atherosclerosis i.e. stroke and myocardial infarction are definable but not the plaque burden.Platelet indices including platelet count and mean platelet volume and soluble mediators released by activated platelets are associated with atherosclerosis. The chemokine CXCL4 has multiple atherogenic activities e.g. altering the differentiation of T cells and macrophages by inhibiting neutrophil and monocyte apoptosis and by increasing the uptake of oxLDL and synergizing with CCL5. CCL5 is released and deposited on endothelium by activated platelets thereby triggering atherogenic monocyte recruitment, which can be attenuated by blocking the corresponding chemokine receptor CCR5. Atheroprotective and plaque stabilizing properties are attributed to CXCL12, which plays an important role in regenerative processes by attracting progenitor cells. Its release from luminal attached platelets accelerates endothelial healing after injury. Platelet surface molecules GPIIb/IIIa, GP1bα, P-selectin, JAM-A and the CD40/CD40L dyade are crucially involved in the interaction with endothelial cells, leukocytes and matrix molecules affecting atherogenesis. Beyond the effects on the arterial inflammatory infiltrate, platelets affect cholesterol metabolism by binding, modifying and endocytosing LDL particles via their scavenger receptors and contribute to the formation of lipid laden macrophages. Current medical therapies for the prevention of atherosclerotic therapies enable the elucidation of mechanisms linking platelets to inflammation

  8. Natural killer T cells in lipoprotein metabolism and atherosclerosis

    OpenAIRE

    Getz, Godfrey S; VanderLaan, Paul A; Reardon, Catherine A

    2011-01-01

    Cells of both the innate and adaptive immune system participate in the development of atherosclerosis, a chronic inflammatory disorder of medium and large arteries. Natural killer T (NKT) cells express surface markers characteristic of natural killer cells and conventional T cells and bridge the innate and adaptive immune systems. The development and activation of NKT cells is dependent upon CD1d, a MHC-class I-type molecule that presents lipids, especially glycolipids to the TCR on NKT cells...

  9. Role of diabetes, hypertension, and cigarette smoking on atherosclerosis

    OpenAIRE

    Mathur, Ram K.

    2010-01-01

    Hyperosmolar food causes atherosclerosis. Hyperosmolal food hypothesis encompasses all the factors involved under one heading and, that is, the generation of heat in the body. The involvement of cigarette smoking is obvious. High glycemic index food and diabetes result in high levels of blood glucose, which raises the core body temperature. The ingestion of hyperosmolal salt, glucose, and amino acids singularly or synergistically raise the core body temperature, forcing abdominal aorta to for...

  10. Melanocortin 1 Receptor Deficiency Promotes Atherosclerosis in Apolipoprotein E-/- Mice.

    Science.gov (United States)

    Rinne, Petteri; Kadiri, James J; Velasco-Delgado, Mauricio; Nuutinen, Salla; Viitala, Miro; Hollmén, Maija; Rami, Martina; Savontaus, Eriika; Steffens, Sabine

    2018-02-01

    The MC1-R (melanocortin 1 receptor) is expressed by monocytes and macrophages where it mediates anti-inflammatory actions. MC1-R also protects against macrophage foam cell formation primarily by promoting cholesterol efflux through the ABCA1 (ATP-binding cassette transporter subfamily A member 1) and ABCG1 (ATP-binding cassette transporter subfamily G member 1). In this study, we aimed to investigate whether global deficiency in MC1-R signaling affects the development of atherosclerosis. Apoe -/- (apolipoprotein E deficient) mice were crossed with recessive yellow (Mc1r e/e ) mice carrying dysfunctional MC1-R and fed a high-fat diet to induce atherosclerosis. Apoe -/- Mc1r e/e mice developed significantly larger atherosclerotic lesions in the aortic sinus and in the whole aorta compared with Apoe -/- controls. In terms of plaque composition, MC1-R deficiency was associated with less collagen and smooth muscle cells and increased necrotic core, indicative of more vulnerable lesions. These changes were accompanied by reduced Abca1 and Abcg1 expression in the aorta. Furthermore, Apoe -/- Mc1r e/e mice showed a defect in bile acid metabolism that aggravated high-fat diet-induced hypercholesterolemia and hepatic lipid accumulation. Flow cytometric analysis of leukocyte profile revealed that dysfunctional MC1-R enhanced arterial accumulation of classical Ly6C high monocytes and macrophages, effects that were evident in mice fed a normal chow diet but not under high-fat diet conditions. In support of enhanced arterial recruitment of Ly6C high monocytes, these cells had increased expression of L-selectin and P-selectin glycoprotein ligand 1. The present study highlights the importance of MC1-R in the development of atherosclerosis. Deficiency in MC1-R signaling exacerbates atherosclerosis by disturbing cholesterol handling and by increasing arterial monocyte accumulation. © 2017 The Authors.

  11. IL-25 inhibits atherosclerosis development in apolipoprotein E deficient mice.

    Directory of Open Access Journals (Sweden)

    Polyxeni T Mantani

    Full Text Available IL-25 has been implicated in the initiation of type 2 immunity and in the protection against autoimmune inflammatory diseases. Recent studies have identified the novel innate lymphoid type 2 cells (ILC2s as an IL-25 target cell population. The purpose of this study was to evaluate if IL-25 has any influence on atherosclerosis development in mice.Administration of 1 μg IL-25 per day for one week to atherosclerosis-prone apolipoprotein (apoE deficient mice, had limited effect on the frequency of T cell populations, but resulted in a large expansion of ILC2s in the spleen. The expansion was accompanied by increased levels of anti-phosphorylcholine (PC natural IgM antibodies in plasma and elevated levels of IL-5 in plasma and spleen. Transfer of ILC2s to apoE deficient mice elevated the natural antibody-producing B1a cell population in the spleen. Treatment of apoE/Rag-1 deficient mice with IL-25 was also associated with extensive expansion of splenic ILC2s and increased plasma IL-5, suggesting ILC2s to be the source of IL-5. Administration of IL-25 in IL-5 deficient mice resulted in an expanded ILC2 population, but did not stimulate generation of anti-PC IgM, indicating that IL-5 is not required for ILC2 expansion but for the downstream production of natural antibodies. Additionally, administration of 1 μg IL-25 per day for 4 weeks in apoE deficient mice reduced atherosclerosis in the aorta both during initiation and progression of the disease.The present findings demonstrate that IL-25 has a protective role in atherosclerosis mediated by innate responses, including ILC2 expansion, increased IL-5 secretion, B1a expansion and natural anti-PC IgM generation, rather than adaptive Th2 responses.

  12. La novela monstruo: La vejez de Heliogábalo de Antonio de Hoyos y el decadentismo

    Directory of Open Access Journals (Sweden)

    Begoña Sáenz Martínez

    2009-11-01

    Full Text Available In the complex conjuncture of the end of Spanish century, Antonio de Hoyos has been identified traditionally as an atypical member of decadent movement. But its narrative is something more than an old fashioned and eccentric intention to take decadent literature to Spain. It is necessary to locate to Pedro in a position that this surpasses the routine classification like "erotic narrative". When I analyze the thematic components based on the general scheme of the decadent literature, I can define the specific nature of this novel, that it is not other than being a Spanish accomplishment of a decadent way of the European narrative.

  13. Autores Clásicos en la biblioteca del ilustrado Antonio Ruiz De Padrón

    Directory of Open Access Journals (Sweden)

    Francisco Salas Salgado

    2014-12-01

    Full Text Available Se estudia en este artículo los libros de autores grecolatinos que poseía la amplia biblioteca del ilustrado canario Antonio Ruiz de Padrón (1757-1823, cuyo conocimiento debemos a los inventarios realizados en 1814 y 1823. Se comprueba de esta manera la vigencia de los autores clásicos propiciada con toda seguridad por enorme importancia que la corriente neoclásica tuvo en la época de la Ilustración.http://dx.doi.org/10.14195/2183-1718_66_20

  14. Usurping the Apocryphal: Antonio Muñoz Molina's Cosmopolitan Memory of Max Aub's Rhetoric of Testimony

    OpenAIRE

    Aguirre Oteiza, Daniel

    2017-01-01

    This paper focuses on a recent gesture by the Spanish novelist and public intellectual Antonio Muñoz Molina to publicly recuperate Aub’s testimony of uprootedness in France, Algeria, and Mexico, a gesture that relies on the concept of cosmopolitan memory as it has been developed in Holocaust studies. I critique Muñoz Molina’s use of the Holocaust as a template for a transnational cultural history based on a supposedly shared Jewish past. Muñoz Molina generalizes on two levels: he turns Aub in...

  15. Status of the First Permanent Molars in Students from the José Antonio Saco Elementary School

    OpenAIRE

    Diosky Ferrer Vílchez; Ana Belkys Hernández Millán; Disney Tablada Peralta; Ana Ivis Betancourt García; Antonio Araujo Vílchez; Yenly Rodríguez Alonso

    2016-01-01

    Background: the first molars are among the first teeth affected by dental caries. Their premature loss leads to occlusion disorders. Objective: to determine the status of the first permanent molars in first-, fourth- and sixth- grade students from the Jose Antonio Saco elementary school in Cienfuegos. Methods: a cross-sectional study was conducted in a universe of 227 students treated at the Raúl González Pediatric Dental Clinic of the health area number 1 in Cienfuegos from October 2014 to M...

  16. Subclinical coronary atherosclerosis and neighbourhood deprivation in an urban region

    International Nuclear Information System (INIS)

    Dragano, Nico; Hoffmann, Barbara; Stang, Andreas; Moebus, Susanne; Verde, Pablo E.; Weyers, Simone; Moehlenkamp, Stefan; Schmermund, Axel; Mann, Klaus; Joeckel, Karl-Heinz; Erbel, Raimund; Siegrist, Johannes

    2009-01-01

    Inhabitants of deprived neighbourhoods are at higher risk of coronary heart disease. In this study we investigate the hypothesis that social inequalities at neighbourhood level become already manifest in subclinical coronary atherosclerosis, as defined by electron-beam computed tomography derived measures. Coronary artery calcification was assessed as a marker of atherosclerosis in a population based sample of 4301 men and women (45-75 years) without a history of coronary heart disease. Participants lived in three adjacent cities in Germany and were examined between 2000 and 2003 as part of the Heinz Nixdorf Recall Study. Individual level data was combined with neighbourhood level information about unemployment, welfare and living space per inhabitant. This dataset was analysed with descriptive and multilevel regression methods. An association between neighbourhood deprivation and subclinical coronary calcification was observed. After adjustment for age and individual socioeconomic status male inhabitants of high unemployment neighbourhoods had an odds ratio of 1.45 (1.11, 1.96) of exhibiting a high calcification score (>75th percentile) compared to men living in low unemployment areas. The respective odds for women was 1.29 (0.97, 1.70). Additional explorative analyses suggest that clustering of unhealthy lifestyles in deprived neighbourhoods contributes to the observed association. In conclusion, findings suggest that certain neighbourhood characteristics promote the emergence of coronary atherosclerosis. This might point to a pathway from neighbourhood deprivation to manifest coronary heart disease

  17. Biomarkers of Subclinical Atherosclerosis in Patients with Autoimmune Disorders

    Directory of Open Access Journals (Sweden)

    Elisabetta Profumo

    2012-01-01

    Full Text Available Atherosclerosis is accelerated in rheumatoid arthritis (RA and psoriatic arthritis (PsA. We investigated a possible association of oxidized low-density lipoproteins (ox-LDLs, nitric oxide (NO, 3-nitrotyrosine, vitamin A, vitamin E, and β-carotene serum levels with subclinical atherosclerosis in RA and PsA. By the use of ELISA, we observed higher ox-LDL levels in patients with intima-media thickness (IMT > 1 than in patients with IMT ≤ 1 and a negative correlation between NO levels and IMT values. By the use of high-performance liquid chromatography, we determined higher levels of vitamin A in patients with PsA and IMT ≤ 1 than in controls and lower levels of β-carotene in patients with RA and PsA than in controls. β-carotene concentrations were negatively correlated to the duration of disease in RA. Our study confirms that ox-LDLs and NO may be markers of accelerated atherosclerosis in RA and PsA whereas vitamins seem to be associated only to the presence of the autoimmune disorders.

  18. Curcumin analog L3 alleviates diabetic atherosclerosis by multiple effects.

    Science.gov (United States)

    Zheng, Bin; Yang, Liu; Wen, Caixia; Huang, Xiuwang; Xu, Chenxia; Lee, Kuan-Han; Xu, Jianhua

    2016-03-15

    L3, an analog of curcumin, is a compound isolated from a traditional Chinese medicine Turmeric. In this paper, we aims to explore the efficacy of L3 on diabetic atherosclerosis and the related mechanism. The effect of L3 was studied on glucose and lipid metabolism, antioxidant status, atherosclerosis-related indexes and pathological changes of main organs in the mice model of diabetes induced by streptozotocin and high-fat diet. The results showed that L3 treatment could meliorate dyslipidemia and hyperglycemia, reduce oxidative stress, enhance the activity of antioxidases, increase the nitric oxide level in plasma and aortic arch, decrease the production of reactive oxygen species in pancreas and lectin-like oxidized low-density lipoprotein receptor-1 expression in aortic arch, and meliorate the fatty and atherosclerotic degeneration in aortic arch, thereby preventing the development of diabetes and its complications. These results suggested that L3 can alleviate the diabetic atherosclerosis by multiple effects. This study provided scientific basis for the further research and clinical application of L3. Copyright © 2016 Elsevier B.V. All rights reserved.

  19. Protective role for properdin in progression of experimental murine atherosclerosis.

    Directory of Open Access Journals (Sweden)

    Tanja Steiner

    Full Text Available Genetic, dietary and immune factors contribute to the pathogenesis of atherosclerosis in humans and mice. Complement activation is an integral part of the innate immune defence but also shapes cellular responses and influences directly triglyceride synthesis. Deficiency of Factor B of the alternative pathway (AP of complement is beneficial in LDLR(-/- mice fed a high fat diet. The serum glycoprotein properdin is a key positive regulator of the AP but has not been studied in experimental atherosclerosis. Atherosclerosis was assessed after feeding low fat (LFD or high fat (HFD Western type diets to newly generated LDLR(-/- Properdin(KO (LDLR(-/-P(KO and LDLR-/-PWT mice. Lipids, lymphocytes and monocytes were similar among genotypes, genders and diets. Complement C3, but not C3adesarg, levels were enhanced in LDLR(-/-P(KO mice regardless of diet type or gender. Non-esterified fatty acids (NEFA were decreased in male LDLR(-/-P(KO fed a HFD compared with controls. All mice showed significant atherosclerotic burden in aortae and at aortic roots but male LDLR(-/- mice fed a LFD were affected to the greatest extent by the absence of properdin. The protective effect of properdin expression was overwhelmed in both genders of LDLR(-/-mice when fed a HFD. We conclude that properdin plays an unexpectedly beneficial role in the development and progression of early atherosclerotic lesions.

  20. Prediabetes is not a risk factor for subclinical coronary atherosclerosis.

    Science.gov (United States)

    Park, Gyung-Min; Cho, Young-Rak; Lee, Seung-Whan; Yun, Sung-Cheol; Won, Ki-Bum; Ann, Soe Hee; Kim, Yong-Giun; Kim, Shin-Jae; Roh, Jae-Hyung; Kim, Young-Hak; Yang, Dong Hyun; Kang, Joon-Won; Lim, Tae-Hwan; Jung, Chang Hee; Koh, Eun Hee; Lee, Woo Je; Kim, Min-Seon; Lee, Ki-Up; Park, Joong-Yeol; Kim, Hong-Kyu; Choe, Jaewon; Lee, Sang-Gon

    2017-09-15

    There are limited data regarding the influence of glycemic status on the risk of subclinical coronary atherosclerosis on coronary computed tomographic angiography (CCTA) in asymptomatic individuals. We analyzed 6434 asymptomatic individuals who underwent CCTA. The degree and extent of subclinical coronary atherosclerosis were assessed by CCTA, and ≥50% diameter stenosis was defined as significant. Of study participants, 2197 (34.1%), 3122 (48.5%), and 1115 (17.3%) were categorized as normal, prediabetic and diabetic individuals, respectively. Compared with normal individuals, there were no statistically differences in the adjusted odds ratios of prediabetic individuals for significant coronary artery stenosis (0.98, 95% confidence interval [CI] 0.80-1.22, p=0.888), any plaque (0.96, 95% CI 0.86-1.07, p=0.483), calcified plaque (0.90, 95% CI 0.79-1.01, p=0.080), non-calcified plaque (1.02, 95% CI 0.88-1.17, p=0.803), and mixed plaque (1.00, 95% CI 0.82-1.22, p=0.983). However, adjusted odds ratios for significant coronary artery stenosis (1.71, 95% CI 1.34-2.19, pprediabetic individuals were not associated with an increased risk of subclinical coronary atherosclerosis. Copyright © 2017 Elsevier B.V. All rights reserved.

  1. Aterosclerose experimental em coelhos Experimental atherosclerosis in rabbits

    Directory of Open Access Journals (Sweden)

    Waleska C. Dornas

    2010-08-01

    Full Text Available Numerosas pesquisas têm sido realizadas utilizando modelos experimentais para estudar o desenvolvimento da aterosclerose com dieta induzindo hiperlipidemia. Devido ao fato de que coelhos são muito sensíveis a dietas ricas em colesterol e acumulam grandes quantidades no plasma, a utilização destes animais como modelo experimental para avaliar o desenvolvimento de aterosclerose é de grande relevância, trazendo informação sobre fatores que contribuem para progressão e regressão aplicadas a situações humanas. Sendo assim, nessa revisão a função aterogênica do colesterol é mostrada em trabalhos que incluem o coelho como modelo experimental, uma vez que este animal tornou-se o mais popular modelo experimental de aterosclerose.Many researches have been conducted in experimental models in order to study the development of atherosclerosis from hyperlipidemia-inducing diets. Since rabbits are very sensitive to cholesterol-rich diets and accumulate large amounts of cholesterol in their plasma, their use as experimental models to evaluate the development of atherosclerosis is highly relevant and brings information on factors that contribute to the progression and regression of this condition that can be applied to humans. As such, this review includes studies on the atherogenic function of cholesterol based on rabbits as the experimental model, since they have become the most largely used experimental model of atherosclerosis.

  2. Food and nutrition in the prevention of atherosclerosis

    Directory of Open Access Journals (Sweden)

    Izabela Kamila Wojarska

    2018-05-01

    Full Text Available Cardiovascular disease is the most frequent cause of hospitalization (15% and death (46% in Poland, as well as worldwide (31%, by reason of strenuous activity in the field of preventative healthcare in all age groups has to be taken. Preventative nutrition of atherosclerosis predicts mostly intake restriction of food containing: fatty acids, cholesterol, salt, monosaccharides and animal protein, while increasing intake of vitamins, minerals, fiber and antioxidant substances. Eating habits and nutritional status of women who are planning pregnancy have a crucial impact on its course, development of the fetus and children’s health in later years of their life. For all of cardiac patients well balanced diet is advised. In preventative care of Cardiovascular Disease it is advised to apply the diet given by a certified dietician and adjusted to fit patient’s needs. It is to remember, that besides a good diet, an important therapeutic factor of the patients with atherosclerosis is physical activity. Cardiovascular disease is a serious concern in Poland, as well as worldwide. Eating habits are playing a big role in pathogenesis and prevention of atherosclerosis.

  3. Effect of ascorbic acid on prevention of hypercholesterolemia induced atherosclerosis.

    Science.gov (United States)

    Das, S; Ray, R; Snehlata; Das, N; Srivastava, L M

    2006-04-01

    The notion that oxidation of lipids and propagation of free radicals may contribute to the pathogenesis of atherosclerosis is supported by a large body of evidence. To circumvent the damage caused by oxygen free radicals, antioxidants are needed which provide the much needed neutralization of free radical by allowing the pairing of electrons. In this study we have investigated the effect of ascorbic acid, a water soluble antioxidant on the development of hypercholesterolemia induced atherosclerosis in rabbits. Rabbits were made hypercholesterolemic and atherosclerotic by feeding 100 mg cholesterol/day. Different doses of ascorbic acid were administered to these rabbits. Low dose of ascorbic acid (0.5 mg/100 g body weight/day) did not have any significant effect on the percent of total area covered by atherosclerotic plaque. However, ascorbic acid when fed at a higher dose (15 mg/100 g body weight/day) was highly effective in reducing the atherogenecity. With this dose the percent of total surface area covered by atherosclerotic plaque was significantly less (p ascorbic acid may have great promise in the prevention of hypercholesterolemia induced atherosclerosis.

  4. Calzadas y soleras de Santiago como elementos patrimoniales: los casos de las calles Lira y Antonio Ricaurte, una tentativa polémica. /The pavements of the streets: Lira and Antonio Ricaute in Santiago, Chile. Heritage objects.

    Directory of Open Access Journals (Sweden)

    Larrañaga, Itxiar

    2006-06-01

    Full Text Available La calle Lira, desde Avda. del Libertador Bernardo O'Higgins hasta Manuel Antonio Matta, destaca por su admirable adoquinado en granito entre soleras del mismo material, y la línea central de tranvía con las tapas de alcantarillado en el centro de la línea. La factura del adoquinado refleja que su realización es de una época del siglo XX en que ya se tenía madurez en el arte de su construcción. Se reflexiona sobre la eventual consideración de estos elementos como objetos culturales y patrimoniales./Lira street, from Libertador Bernardo O’higgins Avenue to Manuel Antonio Matta Avenue, features an admirable cobbled pavement made out of granite as well as the curbs on each side. Along the middle of the street there is a streetcar line, and in between its rails there are sewer lids along the line.The quality of the placing of the cobbles and their materials is proof of a certain maturity in the art of construction during the 20th century. The article proposes that these elements should be considered as cultural heritage objects.

  5. Dialogando con los autores "Dr. Antonio María Béguez César in memoriam" Talking to the authors «Dr. Antonio María Béguez César in memoriam»

    Directory of Open Access Journals (Sweden)

    María Antonia Peña Sánchez

    Full Text Available Como parte de las actividades efectuadas en la XIX Feria Internacional del Libro en Santiago de Cuba, se desarrolló en el Teatro Heredia de esta ciudad el primer encuentro denominado Dialogando con los autores "Dr. Antonio María Béguez César in memoriam", al que asistieron escritores del Repertorio "Los profesionales de la salud santiagueros en las editoriales cubanas y extranjeras", así como otras personalidades de la comunidad científica del territorio y de la Editorial Oriente, algunos de los cuales fueron homenajeados por su encomiable labor en defensa de la veracidad y divulgación de las ciencias médicas y ramas afines.As part of the activities undertaken in the XIX International Book Fair in Santiago de Cuba, the first meeting called Talking to the Authors "Dr. Antonio María Béguez Cesar in memoriam" took place in Heredia theater, attended by writers of the Repertoire "Santiago health professionals in Cuban and foreign publishing houses", as well as other personalities of the scientific community in the territory and the Editorial Oriente, some of whom were honored by their commendable work in defense of truthfulness and spread of medical sciences and related branches.

  6. Reduction of mouse atherosclerosis by urokinase inhibition or with a limited-spectrum matrix metalloproteinase inhibitor

    DEFF Research Database (Denmark)

    Hu, Jie Hong; Touch, Phanith; Zhang, Jingwan

    2015-01-01

    -accelerated atherosclerosis) to investigate whether systemic inhibition of proteolytic activity of uPA or a subset of MMPs can reduce protease-induced atherosclerosis and aortic dilation. METHODS AND RESULTS: SR-uPA mice were fed a high-fat diet for 10 weeks and treated either with an antibody inhibiting mouse uPA (mU1...... surface lesion coverage. Several lines of evidence identified MMP-13 as a mediator of uPA-induced aortic MMP activity. CONCLUSIONS: Pharmacological inhibition of either uPA or selected MMPs decreased atherosclerosis in SR-uPA mice. uPA inhibition decreased aortic dilation. Differential effects of both...... agents on aortic root vs. distal aortic atherosclerosis suggest prevention of atherosclerosis progression vs. initiation. Systemic inhibition of uPA or a subset of MMPs shows promise for treating atherosclerosis....

  7. Periodontal disease and carotid atherosclerosis: A meta-analysis of 17,330 participants.

    Science.gov (United States)

    Zeng, Xian-Tao; Leng, Wei-Dong; Lam, Yat-Yin; Yan, Bryan P; Wei, Xue-Mei; Weng, Hong; Kwong, Joey S W

    2016-01-15

    The association between periodontal disease and carotid atherosclerosis has been evaluated primarily in single-center studies, and whether periodontal disease is an independent risk factor of carotid atherosclerosis remains uncertain. This meta-analysis aimed to evaluate the association between periodontal disease and carotid atherosclerosis. We searched PubMed and Embase for relevant observational studies up to February 20, 2015. Two authors independently extracted data from included studies, and odds ratios (ORs) with 95% confidence intervals (CIs) were calculated for overall and subgroup meta-analyses. Statistical heterogeneity was assessed by the chi-squared test (Pperiodontal disease was associated with carotid atherosclerosis (OR: 1.27, 95% CI: 1.14-1.41; Pperiodontal disease was associated with carotid atherosclerosis; however, further large-scale, well-conducted clinical studies are needed to explore the precise risk of developing carotid atherosclerosis in patients with periodontal disease. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  8. Relationship between Chlamydia pneumonia and helicobacter pylori with atherosclerosis

    Directory of Open Access Journals (Sweden)

    ali Pooria

    2009-01-01

    Full Text Available Pooria A1, Maasoomi M2, Rafiee E3, Rezaee M4, Sabzi F5, Hossain Zadegan H6, Salehi M7, Mozaffari P8 1. Assistant Professor, Department of Surgery, Faculty of Medicine, Lorestan University of Medical Sciences 2. Professor, Department of Surgery, Faculty of Medicine, Kermanshah University of Medical Sciences, 3. Assistant Professor, Faculty of Medicine, Lorestan University of Medical Sciences, Department of Pathology 4. Associate Professor, Department of Surgery, Faculty of Medicine, Kermanshah University of Medical Sciences 5. Assistant Professor, Department of Statistics, Faculty of Health, Kermanshah University of Medical Sciences 6. Assistant Professor, Department of Microbiology, Faculty of Medicine, Lorestan University of Medical Sciences 7. Bsc in Nursing, Kermanshah University of Medical Sciences 8. Instructor, Department of Nursing, Faculty of Nursing and midwifery, Kermanshah University of Medical Sciences Abstract Background: Atherosclerosis is the most common cause of deaths in the developed countries and causes one million mortalities per year in the USA. Smoking, hypertension, diabetes, obesity, hyperlipidemia, stress, and low activity are known to be the causes of atherosclerosis. The objective of this study is to confirm the relationship between chlamydia pneumonia (Cpn, as well as helicobacter pylori (Hp and atherosclerosis. Materials and methods: In this analytical case-control study two groups of patients were studied. The first group including 30 patients over 30 years old with coronary artery disease were operated using coronary artery bypass graft. The control group included 30 persons assessed with angiography and having normal coronary arteries. The data were collected and analyzed using statistical methods. Results: The two groups were similar in terms of IgA and IgG anti-Cpn, and IgG anti- Hp but they were statistically different concerning IgA anti-Hp which had more positive cases in the case group in comparison with the

  9. Antonio Ordóñez Plaja. Académico Honorario

    Directory of Open Access Journals (Sweden)

    Gustavo Malagón Londoño

    2012-04-01

    Full Text Available El pasado 20 de abril registramos con verdadero pesar el fallecimiento de este gran maestro de la medicina colombiana, ejecutivo ejemplar, intachable hombre público, excelente miembro de familia, amigo a toda prueba. Poseedor de una envidiable personalidad y una inagotable inteligencia, como lo demostró hasta los últimos momentos de su vida, siempre se destacó por sus agudos y certeros comentarios sobre la situación del país, sobre los problemas del mundo actual, sobre el presente estado de la salud en Colombia y muy respetuoso del buen nombre de todas las personas, destacó siempre sus valores y se abstuvo de emitir juicios sobre sus defectos. Tuve el privilegio de ser su amigo y disfrutar de largas y cálidas sesiones de amenos comentarios matizados siempre con anécdotas que no escapaban a su privilegiada memoria. En ningún momento se dejó amilanar por la soledad y con las afortunadas visitas frecuentes de su cariñosa hija, acompañado de su empleada doméstica y su mascota, supo superar el vacío inmenso que le dejó su incomparable Beatriz, fallecida hace varios años y quien fue su esposa fiel, confidente y consejera inigualable. Mientras pudo disfrutar de una completa visión, fue insaciable lector y escritor de importantes publicaciones reconocidas como documentos de obligada consulta sobre temas médicos de su especialidad, sobre educación profesional para la salud, sobre condiciones físicas y sociales de la tercera edad, sobre problemas familiares y aspectos de comportamiento de la niñez y la adolescencia, sobre nutrición Infantil. Mientras tuvo condiciones físicas para transportarse, concurrió en forma asidua y participativa a las frecuentes reuniones de la Academia. - See more at: http://www.encolombia.com/medicina/revistas-medicas/academedicina/vol97/antonio-plaja/#sthash.0i1xlqss.dpuf

  10. The acute effects of strength training on inflammatory markers predicting atherosclerosis: a study on inactive middle-aged men

    Directory of Open Access Journals (Sweden)

    Bizheh N

    2011-06-01

    Full Text Available "n Normal 0 false false false EN-US X-NONE AR-SA MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:Arial; mso-bidi-theme-font:minor-bidi;} Background: Cardiovascular diseases, especially atherosclerosis, are the main causes of morbidity and mortality worldwide. The disease has had an increasing prevalence in Iran in recent years. Homocysteine and C-reactive protein (CRP are two novel cardiovascular risk factors that independently predict risks of atherosclerosis. The purpose of this study was to investigate the effects of one session of circuit resistance training on the blood levels of the aforesaid inflammatory markers in inactive middle-aged men."n"nMethods: The participants of this study included twenty-three healthy but inactive middle-aged men who were overweight and were randomly divided into two experimental (n=14 and control (n=9 groups. The activity included doing exercises with the subjects' 35% one-repetition maximum (1-RM intensity at ten different stations. Blood levels of homocysteine and hs-CRP were measured before and after the exercise."n"nResults: Analysis of data using independent samples t-test showed a significant increment in the serum levels of homocysteine and hs-CRP after training in the experimental (P<0.05 versus the control group."n"nConclusion: Elevation of homocysteine levels is due to the increase in protein metabolism

  11. Antonio Zambrana Lara, docente y pintor. Técnica y procedimientos dentro del Realismo Sevillano del último tercio del siglo XX

    OpenAIRE

    Domínguez Moreno, Gustavo

    2012-01-01

    El trabajo que aquí se presenta, cuyo título es Antonio Zambrana Lara, docente y pintor. Técnica y procedimiento dentro del Realismo Sevillano del último tercio del siglo XX, procurará analizar en profundidad las cuestiones relacionadas con la personalidad artística de Antonio Zambrana, a través de diversos asuntos, como por ejemplo su contextualización, intentando profundizar en un momento apasio nante del arte sevillano y especialmente en aquellos apartados que de manera más concreta se ref...

  12. 77 FR 34988 - Notice of Inventory Completion: San Diego State University, San Diego, CA

    Science.gov (United States)

    2012-06-12

    .... ACTION: Notice. SUMMARY: San Diego State University Archeology Collections Management Program has... that believes itself to be culturally affiliated with the human remains and associated funerary objects may contact San Diego State University Archeology Collections Management Program. Repatriation of the...

  13. Atherosclerosis profile and incidence of cardiovascular events: a population-based survey

    Directory of Open Access Journals (Sweden)

    Bullano Michael F

    2009-09-01

    Full Text Available Abstract Background Atherosclerosis is a chronic progressive disease often presenting as clinical cardiovascular disease (CVD events. This study evaluated the characteristics of individuals with a diagnosis of atherosclerosis and estimated the incidence of CVD events to assist in the early identification of high-risk individuals. Methods Respondents to the US SHIELD baseline survey were followed for 2 years to observe incident self-reported CVD. Respondents had subclinical atherosclerosis if they reported a diagnosis of narrow or blocked arteries/carotid artery disease without a past clinical CVD event (heart attack, stroke or revascularization. Characteristics of those with atherosclerosis and incident CVD were compared with those who did not report atherosclerosis at baseline but had CVD in the following 2 years using chi-square tests. Logistic regression model identified characteristics associated with atherosclerosis and incident events. Results Of 17,640 respondents, 488 (2.8% reported having subclinical atherosclerosis at baseline. Subclinical atherosclerosis was associated with age, male gender, dyslipidemia, circulation problems, hypertension, past smoker, and a cholesterol test in past year (OR = 2.2 [all p Conclusion Self-report of subclinical atherosclerosis identified an extremely high-risk group with a >25% risk of a CVD event in the next 2 years. These characteristics may be useful for identifying individuals for more aggressive diagnostic and therapeutic efforts.

  14. [25 year experience with using surgical correction of dislipidemia in treatment of patients with atherosclerosis].

    Science.gov (United States)

    Sedov, V M; Mirchuk, K K; Sedletskiĭ, Iu I

    2011-01-01

    An analysis of results of using partial ileoshunting for the treatment of dislipidemia in 159 patients with atherosclerosis has shown that operation of partial ileoshunting has an obligatory, pronounced and lifelong lipidcorrecting effect. An antiatherogenic effect of the operation of partial ileoshunting is manifested as the improvement of the clinical course of the disease caused by atherosclerosis, by less number of thrombotic complications of atherosclerosis and less lethality from cardio-vascular diseases. At a longer follow-up period, the efficiency of partial ileoshunting as a means of secondary prophylactics of atherosclerosis is confirmed but in case of liquidation after operation of dislipoproteidemia.

  15. Los liberalismos de José María Vigil y Antonio Caso y el realismo directo

    Directory of Open Access Journals (Sweden)

    José Hernández

    2013-11-01

    Full Text Available Jose Maria Vigil (1829-1909 and Antonio Caso (1883-1946 were two defenders of liberal democracy and of the possibility of a limited but effective conscious management of public and social affairs, within the adverse contexts of Mexico during the administration of Porfirio Diaz as well as the post-revolutionary period. Both authors based their positions on a critique concerning positivism and social-historical determinism, which would aim at a way of thinking quite distant from subjectivist thought, although very close to an epistemological "direct realism" that establishes that the world is not actually a subjective or inter-subjective construction, that may be interpreted in the same subjective or inter-subjective way. However, it is not either something that might be known through a mental or conceptual copy or representation of its entities and processes. Perhaps, the most evocative defender of direct realism in history has been the 18* Century Scottish philosopher, Thomas Reid (1710-1796, a great "common-sensist", explicitly recovered by Vigil and vindicated in a tacit manner by Antonio Caso.

  16. Species - San Diego Co. [ds121

    Data.gov (United States)

    California Natural Resource Agency — This is the Biological Observation Database point layer representing baseline observations of sensitive species (as defined by the MSCP) throughout San Diego County....

  17. 75 FR 15611 - Safety Zone; United Portuguese SES Centennial Festa, San Diego Bay, San Diego, CA

    Science.gov (United States)

    2010-03-30

    ...-AA00 Safety Zone; United Portuguese SES Centennial Festa, San Diego Bay, San Diego, CA AGENCY: Coast... navigable waters of the San Diego Bay in support of the United Portuguese SES Centennial Festa. This... Centennial Festa, which will include a fireworks presentation originating from a tug and barge combination in...

  18. 78 FR 34123 - Notice of Inventory Completion: San Francisco State University NAGPRA Program, San Francisco, CA

    Science.gov (United States)

    2013-06-06

    ... completion of an inventory of human remains and associated funerary objects under the control of the San....R50000] Notice of Inventory Completion: San Francisco State University NAGPRA Program, San Francisco, CA... NAGPRA Program has completed an inventory of human remains and associated funerary objects, in...

  19. 78 FR 21403 - Notice of Inventory Completion: San Francisco State University NAGPRA Program, San Francisco, CA

    Science.gov (United States)

    2013-04-10

    ... completion of an inventory of human remains and associated funerary objects under the control of the San....R50000] Notice of Inventory Completion: San Francisco State University NAGPRA Program, San Francisco, CA... NAGPRA Program has completed an inventory of human remains and associated funerary objects, in...

  20. Cuartel San Carlos. Yacimiento veterano

    Directory of Open Access Journals (Sweden)

    Mariana Flores

    2007-01-01

    Full Text Available El Cuartel San Carlos es un monumento histórico nacional (1986 de finales del siglo XVIII (1785-1790, caracterizado por sufrir diversas adversidades en su construcción y soportar los terremotos de 1812 y 1900. En el año 2006, el organismo encargado de su custodia, el Instituto de Patrimonio Cultural del Ministerio de Cultura, ejecutó tres etapas de exploración arqueológica, que abarcaron las áreas Traspatio, Patio Central y las Naves Este y Oeste de la edificación. Este trabajo reseña el análisis de la documentación arqueológica obtenida en el sitio, a partir de la realización de dicho proyecto, denominado EACUSAC (Estudio Arqueológico del Cuartel San Carlos, que representa además, la tercera campaña realizada en el sitio. La importancia de este yacimiento histórico, radica en su participación en los acontecimientos que propiciaron conflictos de poder durante el surgimiento de la República y en los sucesos políticos del siglo XX. De igual manera, se encontró en el sitio una amplia muestra de materiales arqueológicos que reseñan un estilo de vida cotidiana militar, así como las dinámicas sociales internas ocurridas en el San Carlos, como lugar estratégico para la defensa de los diferentes regímenes que atravesó el país, desde la época del imperialismo español hasta nuestros días.

  1. SANS from interpenetrating polymer networks

    International Nuclear Information System (INIS)

    Markotsis, M.G.; Burford, R.P.; Knott, R.B.; Australian Nuclear Science and Technology Organisation, Menai, NSW; Hanley, T.L.; CRC for Polymers,; Australian Nuclear Science and Technology Organisation, Menai, NSW; Papamanuel, N.

    2003-01-01

    Full text: Interpenetrating polymer networks (IPNs) have been formed by combining two polymeric systems in order to gain enhanced material properties. IPNs are a combination of two or more polymers in network form with one network polymerised and/or crosslinked in the immediate presence of the other(s).1 IPNs allow better blending of two or more crosslinked networks. In this study two sets of IPNs were produced and their microstructure studied using a variety of techniques including small angle neutron scattering (SANS). The first system combined a glassy polymer (polystyrene) with an elastomeric polymer (SBS) with the glassy polymer predominating, to give a high impact plastic. The second set of IPNs contained epichlorohydrin (CO) and nitrile rubber (NBR), and was formed in order to produce novel materials with enhanced chemical and gas barrier properties. In both cases if the phase mixing is optimised the probability of controlled morphologies and synergistic behaviour is increased. The PS/SBS IPNs were prepared using sequential polymerisation. The primary SBS network was thermally crosslinked, then the polystyrene network was polymerised and crosslinked using gamma irradiation to avoid possible thermal degradation of the butadiene segment of the SBS. Tough transparent systems were produced with no apparent thermal degradation of the polybutadiene segments. The epichlorohydrin/nitrile rubber IPNs were formed by simultaneous thermal crosslinking reactions. The epichlorohydrin network was formed using lead based crosslinker, while the nitrile rubber was crosslinked by peroxide methods. The use of two different crosslinking systems was employed in order to achieve independent crosslinking thus resulting in an IPN with minimal grafting between the component networks. SANS, Transmission electron microscopy (TEM), and atomic force microscopy (AFM) were used to examine the size and shape of the phase domains and investigate any variation with crosslinking level and

  2. Atherosclerosis induced by arsenic in drinking water in rats through altering lipid metabolism

    International Nuclear Information System (INIS)

    Cheng, Tain-Junn; Chuu, Jiunn-Jye; Chang, Chia-Yu; Tsai, Wan-Chen; Chen, Kuan-Jung; Guo, How-Ran

    2011-01-01

    Arsenic in drinking water is a global environmental health problem, and the exposure may increase cardiovascular and cerebrovascular diseases mortalities, most likely through causing atherosclerosis. However, the mechanism of atherosclerosis formation after arsenic exposure is still unclear. To study the mechanism of atherosclerosis formation after arsenic exposure and explore the role of high cholesterol diet (HCD) in this process, we fed spontaneous hypertensive rats and Wistar Kyoto rats with basal diet or HCD and provided with them drinking water containing arsenic at different ages and orders for 20 consecutive weeks. We measured high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), total cholesterol, triglycerides, heat shock protein 70 (HSP 70), and high sensitive C-reactive protein (hs-CRP) at predetermined intervals and determined expressions of cholesteryl ester transfer protein-1 (CETP-1) and liver X receptor β (LXRβ) in the liver. Atherosclerosis was determined by examining the aorta with hematoxylin and eosin stain. After 20 weeks, we found arsenic, alone or combined with HCD, may promote atherosclerosis formation with transient increases in HSP 70 and hs-CRP. Early combination exposure decreased the HDL-C/LDL-C ratio without changing the levels of total cholesterol and triglyceride until 30 weeks old. Both CETP-1 and LXRβ activities were suppressed, most significantly in early combination exposure. In conclusion, arsenic exposure may induce atherosclerosis through modifying reverse cholesterol transport in cholesterol metabolism and suppressing LXRβ and CEPT-1 expressions. For decreasing atherosclerosis related mortality associated with arsenic, preventing exposure from environmental sources in early life is an important element. - Highlights: → Arsenic causes cardiovascular and cerebrovascular diseases through atherosclerosis. → Arsenic may promote atherosclerosis with transient increase in HSP 70 and hs

  3. Edificación pasiva. Actuaciones sostenibles aplicadas a construcciones existentes. Estudio y análisis del centro de educación infantil San José y San Antonio de Padua

    OpenAIRE

    MARCH OLIVER, RUBÉN; MARTÍNEZ PARREÑO, LOURDES; MATOSES CORBERA, ESTHER; NAJERA LOPEZ, JUAN FRANCISCO

    2013-01-01

    El presente PFG desarrolla conceptos bioclimáticos pasivos, es decir, técnicas y herramientas que emplean recursos de la naturaleza para convertir una edificación existente con carencias en una edificación sostenible y eficiente energéticamente. El proyecto se divide en dos bloques. El primero de ellos trata de los conceptos pasivos de forma general y en el se desarrollan conceptos como el estudio del soleamiento, el estudio climatológico y el estudio de ventilación. Todo ello enmarcado en la...

  4. Effect of tocotrienol on aortic atherosclerosis in diabetic mice

    International Nuclear Information System (INIS)

    Kiani, M.R.B.; Butt, S.A.; Ahmed, T.

    2015-01-01

    Effect of tocotrienol on aortic atherosclerosis in diabetic mice To study the histomorphological effect of tocotrienol on aortic atherosclerosis in diabetic mice having high fat diet. Study Design: Lab based randomized controlled trial. Place and Duration of Study: Army Medical College, Rawalpindi and National Institute of Health, Islamabad from November 2009 to June 2010. Material and Methods: Forty five female BALB/c mice were randomly divided into three groups. The diabetic mice model was established by intraperitoneal injection of streptozotocin (STZ) 40 mg/kg body weight. Group A was given normal laboratory diet, group B high fat diet and group C was given tocotrienol along with high fat diet for 32 weeks. At the end of experiment the mice were sacrificed. The hearts of animals were dissected out and ascending aortae were taken out. The specimen was fixed in 10% formol calcium and processed for paraffin embedding. Five micrometer thick sections were made for haematoxylin and eosin, and Verhoeff's staining. After staining, histomorphologic changes in slides were noted. Results: In contrast to group A, atheroscelrosis developed in groups B and C. Statistically significant atherosclerotic changes were found in the aortae of diabetic mice in group B when compared to group A. On comparison of group A to C, atherosclerotic changes were statistically insignificant. However when group B was compared with group C, the aortic atherosclerotic changes decreased significantly in group C. Conclusion: In diabetics with high fat diet intake, there is an increase in development of atherosclerosis in aorta which can be reduced by tocotrienol. (author)

  5. Periodontal Disease-Induced Atherosclerosis and Oxidative Stress

    Directory of Open Access Journals (Sweden)

    Tomoko Kurita-Ochiai

    2015-09-01

    Full Text Available Periodontal disease is a highly prevalent disorder affecting up to 80% of the global population. Recent epidemiological studies have shown an association between periodontal disease and cardiovascular disease, as oxidative stress plays an important role in chronic inflammatory diseases such as periodontal disease and cardiovascular disease. In this review, we focus on the mechanisms by which periodontopathic bacteria cause chronic inflammation through the enhancement of oxidative stress and accelerate cardiovascular disease. Furthermore, we comment on the antioxidative activity of catechin in atherosclerosis accelerated by periodontitis.

  6. Data on atherosclerosis specific antibody conjugation to nanoemulsions

    Directory of Open Access Journals (Sweden)

    Geoffrey Prévot

    2017-12-01

    Full Text Available This article present data related to the publication entitled “Iron oxide core oil-in-water nanoemulsion as tracer for atherosclerosis MPI and MRI imaging” (Prévot et al., 2017 [1]. Herein we describe the engineering in the baculovirus-insect cell system and purification processes of the human scFv-Fc TEG4-2C antibody, specific of platelets within the atheroma plaque. For molecular targeting purpose, atheroma specific antibody was conjugated to nanoemulsions (NEs using a heterobifunctional linker (DSPE-PEG-maleimide. Atheroma labelling was assayed by immunochemistry on arterial sections from rabbits.

  7. JOSÉ ANTONIO JÁCOME VALDERRAMA (1915-1966 LUMINARIA DE SANTANDER Y DE COLOMBIA

    Directory of Open Access Journals (Sweden)

    Efraím Otero Ruiz

    2010-01-01

    Full Text Available

    (Discurso pronunciado durante la ceremonia de posesión como Miembro Correspondiente Nacional de la Academia de Historia de Santander, Bucaramanga, Mayo 13 de 2009.

    En 2006 pasó casi desapercibido el cuadragésimo aniversario de la muerte de José Antonio Jácome Valderrama, una de las mentalidades médicas más luminosas del país en el siglo XX. Fallecido apenas al cumplir los 51 de su edad, su estrella brilló por 25 años ascendiendo a las posiciones más altas de la salud en Colombia. Por eso creímos, cuando se conmemoró el medio siglo del Colegio Médico de Santander, que nada hubiera sido más oportuno que evocar la memoria de quien fuera no solo fundador y alto exponente de la Federación Médica Colombiana (de la que recibió su máxima condecoración en 1963 sino incondicional estandarte de su tierra, de sus valores y de su gente.

    Nacido en Bucaramanga el 16 de febrero de 1915, su madre fue una de esas nueve bellas mujeres que unieron sus genes con los de los varones más ilustres y de mayor raigambre dentro de la sociedad santandereana. El mismo relató así algunas de las circunstancias de su nacimiento : “Soy hijo de José Domingo Jácome Niz y Matilde Valderrama de Jácome Niz, ambos ya fallecidos, a quienes debo tánto por la educación que me dieron, por el ejemplo admirable que me ofrecieron, por la formación moral con que forjaron mi espíritu y mi corazón y sobre todo por el amor entrañable y cordial que hizo de nuestro hogar un sitio lleno de felicidad, a pesar de todas las vicisitudes que tuvimos que soportar”.1 1

    Los Jácome Niz provenían de Ocaña, ciudad que desde la colonia mantuvo vínculos con Bucaramanga, por el relativamente cercano acceso de ambas al río Magdalena, en contraste con las fragorosas montañas que había que cruzar desde cada una de ellas para llegar a Cúcuta y a la frontera venezolana. En sus viajes entre una y otra, ya para

  8. Prevalence and long-term clinical significance of intracranial atherosclerosis after ischaemic stroke or transient ischaemic attack

    DEFF Research Database (Denmark)

    Ovesen, Christian; Abild, Annemette; Christensen, Anders Fogh

    2013-01-01

    We investigated the prevalence and long-term risk associated with intracranial atherosclerosis identified during routine evaluation.......We investigated the prevalence and long-term risk associated with intracranial atherosclerosis identified during routine evaluation....

  9. Depressive and anxiety disorders and risk of subclinical atherosclerosis Findings from the Netherlands Study of Depression and Anxiety (NESDA)

    NARCIS (Netherlands)

    Seldenrijk, Adrie; Vogelzangs, Nicole; van Hout, Hein P. J.; van Marwijk, Harm W. J.; Diamant, Michaela; Penninx, Brenda W. J. H.

    Objective: Current evidence regarding the association between psychopathology and subclinical atherosclerosis show inconsistent results. The present study examined whether subclinical atherosclerosis was more prevalent in a large cohort of persons with depressive or anxiety disorders as compared to

  10. Trouble Brewing in San Francisco. Policy Brief

    Science.gov (United States)

    Buck, Stuart

    2010-01-01

    The city of San Francisco will face enormous budgetary pressures from the growing deficits in public pensions, both at a state and local level. In this policy brief, the author estimates that San Francisco faces an aggregate $22.4 billion liability for pensions and retiree health benefits that are underfunded--including $14.1 billion for the city…

  11. San Diego's High School Dropout Crisis

    Science.gov (United States)

    Wilson, James C.

    2012-01-01

    This article highlights San Diego's dropout problem and how much it's costing the city and the state. Most San Diegans do not realize the enormous impact high school dropouts on their city. The California Dropout Research Project, located at the University of California at Santa Barbara, has estimated the lifetime cost of one class or cohort of…

  12. Of Herbs, Animals and other Poisons: Magical Renewal in «El peregrino indiano» by Antonio Saavedra Guzmán

    Directory of Open Access Journals (Sweden)

    Raúl Marrero-Fente

    2017-11-01

    Full Text Available El peregrino indiano by Antonio de Saavedra Guzmán incorporates new substances into the magic spell. In addition to La Araucana, there are ingredients that come from other discursive traditions: the Renaissance treatises of natural history, the Bible, bestiaries, emblematic literature, magic and grimoires.

  13. La politización en las lecturas canónicas: Miguel Antonio Caro, lector de Jorge Isaacs

    Directory of Open Access Journals (Sweden)

    Carlos Arturo López Jiménez

    2008-12-01

    Full Text Available The article herein shows some conceptual features of Miguel Antonio Caro’s intellectual project and its intrinsic strengths. Furthermore, it details the type of politicization which Caro imposed on some of the work of his contemporaries politicization which, in turn, was later imposed on him-self by contemporary historiography. More to the point, I evidence how Caro, when asserting that a particular text by Jorge Isaacs (The native tribes of the Magdalena basin was scientific, immediately proceeded to politicize Isaac’s work, among other things, because he (Caro did not have the relevant arguments needed to confront Isaacs’ text in its own terms and framework. Thus, in order to dismiss Isaacs’ objections raised against the government of Nuñez, Caro places the aforementioned work by the author of María, among the texts that threatened social order by presenting it as part and parcel of positivism, empiricism, liberalism, and all other intellectual efforts based on a damaging sensualism.//Aquí muestran algunos aspectos conceptuales del proyecto intelectual de Miguel Antonio Caro y su consistencia interna. Además, preciso el tipo específico de politización que este escritor impuso sobre algunos trabajos que le fueron contemporáneos –politización de la cual el mismo Caro ha sido objeto por parte de historiografía contemporánea–. Específicamente, presento cómo Miguel Antonio Caro, al afirmar que un texto de Isaacs (Las tribus indígenas del Magdalena es científico, politiza su trabajo por la imposibilidad de atacarlo dentro de los límites argumentativos del texto de Isaacs. De esta forma, para hacer a un lado las objeciones que Isaac eleva contra el gobierno de Núñez, Caro ubica el trabajo del autor de María en el grupo de escritos que amenazan el orden social, al presentarlo de la mano con el positivismo, empirismo, liberalismo y demás esfuerzos intelectuales fundados en un “nocivo” criterio sensualista.

  14. Oxidized low-density lipoprotein-induced apoptotic dendritic cells as a novel therapy for atherosclerosis

    NARCIS (Netherlands)

    Frodermann, Vanessa; van Puijvelde, Gijs H M; Wierts, Laura; Lagraauw, H Maxime; Foks, Amanda C; van Santbrink, Peter J; Bot, Ilze; Kuiper, Johan; de Jager, Saskia C A

    2015-01-01

    Modulation of immune responses may form a powerful approach to treat atherosclerosis. It was shown that clearance of apoptotic cells results in tolerance induction to cleared Ags by dendritic cells (DCs); however, this seems impaired in atherosclerosis because Ag-specific tolerance is lacking. This

  15. Modulation of genes involved in inflammation and cell death in atherosclerosis-susceptible mice

    NARCIS (Netherlands)

    Zadelaar, Anna Susanne Maria

    2006-01-01

    In this thesis we focus on atherosclerosis as the main cause of cardiovascular disease. Since inflammation and cell death are important processes in the onset and progression of atherosclerosis, we investigate the role of several genes involved in inflammation and cell death in the vessel wall and

  16. Torcetrapib does not reduce atherosclerosis beyond atorvastatin and induces more proinflammatory lesions than atorvastatin

    NARCIS (Netherlands)

    de Haan, Willeke; de Vries-van der Weij, Jitske; van der Hoorn, Jose W. A.; Gautier, Thomas; van der Hoogt, Caroline C.; Westerterp, Marit; Romijn, Johannes A.; Jukema, J. Wouter; Havekes, Louis M.; Princen, Hans M. G.; Rensen, Patrick C. N.

    2008-01-01

    Background-Although cholesteryl ester transfer protein (CETP) inhibition is regarded as a promising strategy to reduce atherosclerosis by increasing high-density lipoprotein cholesterol, the CETP inhibitor torcetrapib given in addition to atorvastatin had no effect on atherosclerosis and even

  17. Prevalence, Vascular Distribution, and Multiterritorial Extent of Subclinical Atherosclerosis in a Middle-Aged Cohort

    DEFF Research Database (Denmark)

    Fernández-Friera, Leticia; Peñalvo, José L; Fernández-Ortiz, Antonio

    2015-01-01

    age, 45.8 years; 63% male) to evaluate the systemic extent of atherosclerosis in the carotid, abdominal aortic, and iliofemoral territories by 2-/3-dimensional ultrasound and coronary artery calcification by computed tomography. The extent of subclinical atherosclerosis, defined as presence of plaque...

  18. Associations between vitamin D status and atherosclerosis among Inuit in Greenland

    DEFF Research Database (Denmark)

    Gjødesen, Camilla U; Jørgensen, Marit E; Bjerregaard, Peter

    2018-01-01

    BACKGROUND AND AIMS: Low levels of vitamin D are suspected to be a risk factor for cardiovascular disease and atherosclerosis. The aim of this study was to assess the prevalence of subclinical atherosclerosis among Inuit in Greenland, and to evaluate the association with vitamin D status. We hypo...

  19. Progression and regression of atherosclerosis in APOE3-Leiden transgenic mice : An immunohistochemical study

    NARCIS (Netherlands)

    Gijbels, M.J.J.; Cammen, M. van der; Laan, L.J.W. van der; Emeis, J.J.; Havekes, L.M.; Hofker, M.H.; Kraal, G.

    1999-01-01

    Apolipoprotein E3-Leiden (APOE3-Leiden) transgenic mice develop hyperlipidemia and are highly susceptible to diet-induced atherosclerosis. We have studied the progression and regression of atherosclerosis using immunohistochemistry. Female transgenic mice were fed a moderate fat diet to study

  20. Risk factors for atherosclerosis - can they be used to identify the ...

    African Journals Online (AJOL)

    Risk factors are often used in preventive care programmes to identify the patient at particular risk for developing atherosclerosis. Risk factors for atherosclerosis have also been shown to be linked to the presence of the disease at a given time, a fact that may be helpful when screening for additional atherosclerotic disease in ...

  1. Models and Analysis of Atherosclerosis, Restenosis, and Aneurysm Formation in the Mouse

    NARCIS (Netherlands)

    de Waard, Vivian; Gijbels, Marion J. J.; Lutgens, Esther; de Winther, Menno P. J.; de Vries, Carlie J. M.

    2012-01-01

    Atherosclerosis is considered a chronic inflammatory condition of the vessel wall and involves a high chronic concentration of low-density lipoprotein (LDL) in blood. In humans, restenosis develops after intravascular interventions such as angioplasty and stent placement to treat atherosclerosis,

  2. A pilot study into measurements of markers of atherosclerosis in periodontitis

    NARCIS (Netherlands)

    Leivadaros, Efstratios; van der Velden, Ubele; Bizzarro, Sergio; ten Heggeler, Johanna M. A. G.; Gerdes, Victor E. A.; Hoek, Frans J.; Nagy, Thomas O. M.; Scholma, Jose; Bakker, Stephan J. L.; Gans, Rijk O. B.; ten Cate, Hugo; Loos, Bruno G.

    2005-01-01

    Periodontitis may be a possible risk factor for atherosclerosis. The current pilot study explored arterial wall thickness and other variables associated with atherosclerosis in healthy subjects with and without periodontitis. Patients with moderate (N = 34) and severe periodontitis (N = 15) and

  3. White Matter Lesions, Carotid and Coronary Atherosclerosis in Late-Onset Depression and Healthy Controls

    DEFF Research Database (Denmark)

    Devantier, Torben Albert; Nørgaard, Bjarne Linde; Poulsen, Mikael Kjær

    2016-01-01

    BACKGROUND: Cerebral white matter lesions (WMLs) are more common in individuals with late-onset or late-life depression. It has been proposed that carotid atherosclerosis may predispose to WMLs by inducing cerebral hypoperfusion. This hemodynamic effect of carotid atherosclerosis could be importa...

  4. Predictors of endothelial dysfunction and atherosclerosis in rheumatoid arthritis in Indian population

    Directory of Open Access Journals (Sweden)

    Inderjeet Verma

    2017-03-01

    Conclusions: In the present study, FMD and CIMT were impaired in RA, indicating endothelial dysfunction and accelerated atherosclerosis respectively. CRP, TNF-α, serum nitrite, DAS-28 and depleted EPC population predicted endothelial dysfunction. Age, IL-6, HDL, LDL and depleted EPC population predicted accelerated atherosclerosis.

  5. Atherosclerosis and liver inflammation induced by increased dietary cholesterol intake: A combined transcriptomics and metabolomics analysis

    NARCIS (Netherlands)

    Kleemann, R.; Verschuren, L.; Erk, M.J. van; Nikolsky, Y.; Cnubben, N.H.P.; Verheij, E.R.; Smilde, A.K.; Hendriks, H.F.J.; Zadelaar, A.S.M.; Smith, G.J.; Kaznacheev, V.; Nikolskaya, T.; Melnikov, A.; Hurt-Camejo, E.; Greef, J. van der; Ommen, B. van; Kooistra, T.

    2007-01-01

    Background: Increased dietary cholesterol intake is associated with atherosclerosis. Atherosclerosis development requires a lipid and an inflammatory component. It is unclear where and how the inflammatory component develops. To assess the role of the liver in the evolution of inflammation, we

  6. Small animal positron emission tomography imaging and in vivo studies of atherosclerosis

    DEFF Research Database (Denmark)

    Hag, Anne Mette Fisker; Ripa, Rasmus Sejersten; Pedersen, Sune Folke

    2013-01-01

    Atherosclerosis is a growing health challenge globally, and despite our knowledge of the disease has increased over the last couple of decades, many unanswered questions remain. As molecular imaging can be used to visualize, characterize and measure biological processes at the molecular and cellu...... knowledge obtained from in vivo positron emission tomography studies of atherosclerosis performed in small animals....

  7. Identifying novel genes for atherosclerosis through mouse-human comparative genetics

    NARCIS (Netherlands)

    Wang, XS; Ishimori, N; Korstanje, R; Rollins, J; Paigen, B

    Susceptibility to atherosclerosis is determined by both environmental and genetic factors. Its genetic determinants have been studied by use of quantitative- trait - locus ( QTL) analysis. So far, 21 atherosclerosis QTLs have been identified in the mouse: 7 in a high- fat - diet model only, 9 in a

  8. Las características de los órganos italianos en la época de Antonio de Cabezón

    Directory of Open Access Journals (Sweden)

    Donati, Pier Paolo

    2014-12-01

    Full Text Available In 1548 Antonio de Cabezon was able to take a trip to Italy. On that occasion, he could certainly learn and play the organ Italian. New sources and unpublished documents have recently enabled us to identify a new and reliable profi le of the organs of Italian origins. Eliminated false history, errors of chronology and clichés, the acquisition of technical data other than those handed down by tradition have opened a new historical perspective of which is here given an account. Updated illustration of the characteristics of the organs of the Italian Renaissance follow the guidelines of performance practice entailed and a comparison with the Spanish instruments practiced by Antonio de Cabezon.En 1548 Antonio de Cabezón fue capaz de hacer un viaje a Italia. En esa ocasión, él sin duda podría aprender y tocar el órgano italiano. Las nuevas fuentes y documentos inéditos, nos han permitido recientemente para identifi car un perfi l nuevo y confi able de los órganos de origen italiano. Eliminado los errores históricos, falsos de fecha y clichés, la adquisición de los datos técnicos distintos de los transmitida por tradición han abierto una nueva perspectiva histórica de la cual aquí se da cuenta. Ilustración actualizada de las características de los órganos del Renacimiento italiano sigue las directrices de la práctica interpretativa que derivan de ella y un enfrentamiento con los instrumentos españoles practicadas por Antonio de Cabezón. [it] Le caratteristiche degli organi italiani al tempo di Antonio de Cabezón Nel 1548 Antonio de Cabezón ebbe modo di compiere un viaggio in Italia. In quell’occasione poté sicuramente conoscere e suonare gli organi italiani. Nuove fonti e inediti documenti hanno recentemente permesso di delineare un nuovo ed attendibile profi lo degli organi italiani delle origini. Eliminati falsi storici, errori di cronologia e luoghi comuni, l’acquisizione di dati tecnici diversi da quelli tramandati

  9. Biological signatures of asymptomatic extra- and intracranial atherosclerosis: the Barcelona-AsIA (Asymptomatic Intracranial Atherosclerosis) study.

    Science.gov (United States)

    López-Cancio, Elena; Galán, Amparo; Dorado, Laura; Jiménez, Marta; Hernández, María; Millán, Mónica; Reverté, Silvia; Suñol, Anna; Barallat, Jaume; Massuet, Anna; Alzamora, Maria Teresa; Dávalos, Antonio; Arenillas, Juan Francisco

    2012-10-01

    Intracranial atherosclerotic disease (ICAD) remains a challenge for stroke primary and secondary prevention. Molecular pathways involved in the development of ICAD from its asymptomatic stages are largely unknown. In our population-based study, we aimed to compare the risk factor and biomarker profiles associated with intracranial and extracranial asymptomatic cerebral atherosclerosis. The Asymptomatic Intracranial Atherosclerosis (AsIA) study cohort includes a random sample population of 933 white subjects >50 years with a moderate to high vascular risk (based on REGICOR score) and without a history of stroke (64% males; mean age, 66 years). Carotid and intracranial atherosclerosis were screened by cervical and transcranial color-coded Duplex ultrasound, being moderate to severe stenoses confirmed by MR angiography. We registered clinical and anthropometric data and created a biobank with blood samples at baseline. A panel of biomarkers involved in atherothrombogenesis was determined: C-reactive protein, asymmetric-dimethylarginine, resistin, and plasminogen activator inhibitor-1. Insulin resistance was quantified by Homeostasis Model Assessment index. After multinomial regression analyses, male sex, hypertension, smoking, and alcoholic habits were independent risk factors of isolated extracranial atherosclerotic disease. Diabetes and metabolic syndrome conferred a higher risk for ICAD than for extracranial atherosclerotic disease. Moreover, metabolic syndrome and insulin resistance were independent risk factors of moderate to severe ICAD but were not risk factors of moderate to severe extracranial atherosclerotic disease. Regarding biomarkers, asymmetric-dimethylarginine was independently associated with isolated ICAD and resistin with combined ICAD-extracranial atherosclerotic disease. Our findings show distinct clinical and biological profiles in subclinical ICAD and extracranial atherosclerotic disease. Insulin resistance emerged as an important molecular

  10. Coronary, Carotid, and Lower-extremity Atherosclerosis and Their Interrelationship in Danish Patients with Systemic Lupus Erythematosus

    DEFF Research Database (Denmark)

    Kay, Susan Due; Poulsen, Mikael Kjaer; Diederichsen, Axel Cosmus Pyndt

    2015-01-01

    OBJECTIVE: Atherosclerosis is highly prevalent among patients with systemic lupus erythematosus (SLE), but has been demonstrated predominantly in non-European SLE cohorts and few investigations have included more than 1 imaging modality. We aimed to investigate the prevalence of atherosclerosis...... regression model, age (p Systemic Lupus International Collaborating Clinics (SLICC; p = 0.008) were significant independent risk factors for atherosclerosis at any vascular territory. CONCLUSION: Atherosclerosis is highly prevalent among Danish patients with SLE...

  11. Estudio y recuperación de la Iglesia de San Lorenzo, Úbeda (Jaén = Study and Recovery of the Church of San Lorenzo, Úbeda (Jaén

    Directory of Open Access Journals (Sweden)

    José Manuel Almansa Moreno

    2016-05-01

    Full Text Available Suprimida como parroquia en el siglo XIX y expoliada durante la Guerra Civil de 1936, la antigua iglesia parroquial de San Lorenzo de Úbeda (Jaén inició un imparable proceso de deterioro que amenazó incluso con arruinar totalmente la fábrica. Gracias a la intervención privada de la Fundación “Huerta de San Antonio”, dicho deterioro se ha frenado y se han iniciado tareas de consolidación del templo. Durante las últimas intervenciones se han descubierto numerosos vestigios de gran interés, que han venido a arrojar nuevos datos sobre la evolución histórica del edificio, y que pasamos a analizar en este estudio. Suppressed as a parish in the 19th century and plundered during the Civil War in 1936, the ancient Church of Sant Lawrence of Úbeda (Jaén started an unstoppable process of deterioration which threatened even with completely ruin of the factory. Thanks to the intervention of the private foundation «Huerta de San Antonio», the process of damage has been stopped and the recovering and consolidation works in the temple have started. During this intervention, several remains of great interest have been discovered, which offer new data on the historical evolution of the building, that will be analyzed in this study.

  12. Circulating Endothelial Microparticles: A Key Hallmark of Atherosclerosis Progression

    Directory of Open Access Journals (Sweden)

    Keshav Raj Paudel

    2016-01-01

    Full Text Available The levels of circulating microparticles (MPs are raised in various cardiovascular diseases. Their increased level in plasma is regarded as a biomarker of alteration in vascular function. The prominent MPs present in blood are endothelial microparticles (EMPs described as complex submicron (0.1 to 1.0 μm vesicles like structure, released in response to endothelium cell activation or apoptosis. EMPs possess both physiological and pathological effects and may promote oxidative stress and vascular inflammation. EMPs release is triggered by inducer like angiotensin II, lipopolysaccharide, and hydrogen peroxide leading to the progression of atherosclerosis. However, there are multiple physiological pathways for EMPs generation like NADPH oxidase derived endothelial ROS formation, Rho kinase pathway, and mitogen-activated protein kinases. Endothelial dysfunction is a key initiating event in atherosclerotic plaque formation. Atheroemboli, resulting from ruptured carotid plaques, is a major cause of stroke. Increasing evidence suggests that EMPs play an important role in the pathogenesis of cardiovascular disease, acting as a marker of damage, either exacerbating disease progression or triggering a repair response. In this regard, it has been suggested that EMPs have the potential to act as biomarkers of disease status. This review aims to provide updated information of EMPs in relation to atherosclerosis pathogenesis.

  13. A clinically applicable adjuvant for an atherosclerosis vaccine in mice.

    Science.gov (United States)

    Kobiyama, Kouji; Vassallo, Melanie; Mitzi, Jessica; Winkels, Holger; Pei, Hong; Kimura, Takayuki; Miller, Jacqueline; Wolf, Dennis; Ley, Klaus

    2018-06-22

    Vaccination with MHC-II-restricted peptides from Apolipoprotein B (ApoB) with complete and incomplete Freund's adjuvant (CFA/IFA) is known to protect mice from atherosclerosis. This vaccination induces antigen-specific IgG1 and IgG2c antibody responses and a robust CD4 T cell response in lymph nodes. However, CFA/IFA cannot be used in humans. To find a clinically applicable adjuvant, we tested the effect of vaccinating Apoe-deficient mice with ApoB peptide P6 (TGAYSNASSTESASY). In a broad screening experiment, Addavax, a squalene oil similar to MF59, was the only adjuvant that showed similar efficacy as CFA/IFA. This was confirmed in a confirmation experiment for both the aortic arch and whole aorta analyzed by en face analysis after atherosclerotic lesion staining. Mechanistically, restimulated peritoneal cells from mice immunized with P6 in Addavax released significant amounts of IL-10. Unlike P6 in CFA/IFA, vaccination with P6 in Addavax did not induce any detectable IgG1 or IgG2c antibodies to P6. These data suggest that squalene-based adjuvants such as MF59 are good candidate adjuvants for developing a clinically effective atherosclerosis vaccine. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

  14. Citrus Flavonoids as Regulators of Lipoprotein Metabolism and Atherosclerosis.

    Science.gov (United States)

    Mulvihill, Erin E; Burke, Amy C; Huff, Murray W

    2016-07-17

    Citrus flavonoids are polyphenolic compounds with significant biological properties. This review summarizes recent advances in understanding the ability of citrus flavonoids to modulate lipid metabolism, other metabolic parameters related to the metabolic syndrome, and atherosclerosis. Citrus flavonoids, including naringenin, hesperitin, nobiletin, and tangeretin, have emerged as potential therapeutics for the treatment of metabolic dysregulation. Epidemiological studies reveal an association between the intake of citrus flavonoid-containing foods and a decreased incidence of cardiovascular disease. Studies in cell culture and animal models, as well as a limited number of clinical studies, reveal the lipid-lowering, insulin-sensitizing, antihypertensive, and anti-inflammatory properties of citrus flavonoids. In animal models, supplementation of rodent diets with citrus flavonoids prevents hepatic steatosis, dyslipidemia, and insulin resistance primarily through inhibition of hepatic fatty acid synthesis and increased fatty acid oxidation. Citrus flavonoids blunt the inflammatory response in metabolically important tissues including liver, adipose, kidney, and the aorta. The mechanisms underlying flavonoid-induced metabolic regulation have not been completely established, although several potential targets have been identified. In mouse models, citrus flavonoids show marked suppression of atherogenesis through improved metabolic parameters as well as through direct impact on the vessel wall. Recent studies support a role for citrus flavonoids in the treatment of dyslipidemia, insulin resistance, hepatic steatosis, obesity, and atherosclerosis. Larger human studies examining dose, bioavailability, efficacy, and safety are required to promote the development of these promising therapeutic agents.

  15. Smoking and atherosclerosis: mechanisms of disease and new therapeutic approaches.

    Science.gov (United States)

    Siasos, Gerasimos; Tsigkou, Vasiliki; Kokkou, Eleni; Oikonomou, Evangelos; Vavuranakis, Manolis; Vlachopoulos, Charalambos; Verveniotis, Alexis; Limperi, Maria; Genimata, Vasiliki; Papavassiliou, Athanasios G; Stefanadis, Christodoulos; Tousoulis, Dimitris

    2014-01-01

    It has been clear that at least 1 billion adults worldwide are smokers and at least 700 million children are passive smokers at home. Smoking exerts a detrimental effect to many organ systems and is responsible for illnesses such as lung cancer, pneumonia, chronic obstructive pulmonary disease, cancer of head and neck, cancer of the urinary and gastrointestinal tract, periodontal disease, cataract and arthritis. Additionally, smoking is an important modifiable risk factor for the development of cardiovascular disease such as coronary artery disease, stable angina, acute coronary syndromes, sudden death, stroke, peripheral vascular disease, congestive heart failure, erectile dysfunction and aortic aneurysms via initiation and progression of atherosclerosis. A variety of studies has proved that cigarette smoking induces oxidative stress, vascular inflammation, platelet coagulation, vascular dysfunction and impairs serum lipid pro-file in both current and chronic smokers, active and passive smokers and results in detrimental effects on the cardiovascular system. The aim of this review is to depict the physical and biochemical properties of cigarette smoke and, furthermore, elucidate the main pathophysiological mechanisms of cigarette-induced atherosclerosis and overview the new therapeutic approaches for smoking cessation and augmentation of cardiovascular health.

  16. Telomere Length and the Cancer-Atherosclerosis Trade-Off.

    Directory of Open Access Journals (Sweden)

    Rivka C Stone

    2016-07-01

    Full Text Available Modern humans, the longest-living terrestrial mammals, display short telomeres and repressed telomerase activity in somatic tissues compared with most short-living small mammals. The dual trait of short telomeres and repressed telomerase might render humans relatively resistant to cancer compared with short-living small mammals. However, the trade-off for cancer resistance is ostensibly increased age-related degenerative diseases, principally in the form of atherosclerosis. In this communication, we discuss (a the genetics of human telomere length, a highly heritable complex trait that is influenced by genetic ancestry, sex, and paternal age at conception, (b how cancer might have played a role in the evolution of telomere biology across mammals, (c evidence that in modern humans telomere length is a determinant (rather than only a biomarker of cancer and atherosclerosis, and (d the potential influence of relatively recent evolutionary forces in fashioning the variation in telomere length across and within populations, and their likely lasting impact on major diseases in humans. Finally, we propose venues for future research on human telomere genetics in the context of its potential role in shaping the modern human lifespan.

  17. Subclinical thyroid dysfunction and risk of carotid atherosclerosis.

    Directory of Open Access Journals (Sweden)

    Hosu Kim

    Full Text Available The effect of subclinical thyroid dysfunction on vascular atherosclerosis remains uncertain. The objective of this study was to elucidate the association between sustained subclinical thyroid dysfunction and carotid plaques, which are an early surrogate marker of systemic atherosclerosis.The study included 21,342 adults with consistent thyroid hormonal status on serial thyroid function tests (TFTs and carotid artery duplex ultrasonography at a health screening center between 2007 and 2014. The effect of subclinical thyroid dysfunction on baseline carotid plaques and newly developed carotid plaques during 5-year follow-up was determined by logistic regression analyses and GEE (Generalized Estimating Equations, respectively.Carotid plaques were more common in the subclinical hypothyroidism (55.6% than the euthyroidism (47.8% at baseline. However, in multivariable analysis, thyroid status was not a significant risk for the carotid plaques at baseline. Instead, traditional cardiovascular risk factors, such as age (P <0.001, systolic blood pressure (P = 0.023, fasting blood glucose (P = 0.030, and creatinine (P = 0.012 were associated with baseline carotid plaques in subclinical hypothyroidism. In longitudinal analyses of subjects who were followed up for more than 5 years, there was no significant difference in the cumulative incidence of new carotid plaques according to time between subjects with subclinical hypothyroidism and those with euthyroidism (P = 0.392.Sustained subclinical thyroid dysfunction did not affect the baseline or development of carotid plaques in healthy individuals.

  18. Aortic smooth muscle cell proteoglycan synthesis in relation to atherosclerosis

    International Nuclear Information System (INIS)

    Edwards, I.J.

    1989-01-01

    Proteoglycans (PG) are implicated in atherogenesis by their effects on tissue permeability and cell proliferation and their interaction with plasma low density lipoproteins. Using the pigeon model in which an atherosclerosis-susceptible (WC) and -resistant (SR) breed can be compared, PG synthesis by cultured aortic smooth muscle cells was examined by the use of [ 35 S]-sodium sulfate and [ 3 H]-serine or [ 3 H]-glucosamine as labeling precursors. In both SR and WC cells, the majority of newly synthesized PG were secreted into the media. Chondroitin sulfate (CS) PG and dermatan sulfate (DS) PG were the major PG produced. Total PG production was consistently lower in WC compared to SR cultures due in part to reduce PG synthesis but also to degradation of newly synthesized PG. Since increased DS-PG accompanines atherosclerosis progression, experiments were designed to test the hypothesis that macrophages modulate smooth muscle cell metabolism to cause increase DS-PG production. Cultured WC aortic smooth muscle cells were exposed to the media of cholesteryl ester-loaded pigeon peritoneal macrophages or a macrophage cell line P388D1 and the production of PG examined. Increasing concentration of conditioned media from both types of macrophages caused increased incorporation of 35 S-sulfate into secreted PG, but no change in cell-associated PG. Lipopolysaccharide activation of P388D1 cells enhanced the effect

  19. Wine, alcohol and atherosclerosis: clinical evidences and mechanisms

    Directory of Open Access Journals (Sweden)

    P.L. da Luz

    2004-09-01

    Full Text Available Atherosclerosis is a chronic inflammatory disease which may cause obstructions of the coronary, cerebral and peripheral arteries. It is typically multifactorial, most often dependent on risk factors such as hypercholesterolemia, diabetes, smoking, hypertension, sedentarism, and obesity. It is the single main cause of death in most developed countries due to myocardial infarction, angina, sudden death, and heart failure. Several epidemiological studies suggest that moderate alcohol intake, especially red wine, decrease cardiac mortality due to atherosclerosis. The alcohol effect is described by a J curve, suggesting that moderate drinkers may benefit while abstainers and heavy drinkers are at higher risk. Experimental studies indicate that most beneficial effects of drinking are attributable to flavonoids that are present in red wine, purple grape juice and several fruits and vegetables. The mechanisms include antiplatelet actions, increases in high-density lipoprotein, antioxidation, reduced endothelin-1 production, and increased endothelial nitric oxide synthase expression which causes augmented nitric oxide production by endothelial cells. These findings lead to the concept that moderate red wine drinking, in the absence of contraindications, may be beneficial to patients who are at risk of atherosclerotic cardiovascular events. Moreover, a diet based on fruits and vegetables containing flavonoids may be even more beneficial.

  20. Advanced Imaging of Intracranial Atherosclerosis: Lessons from Interventional Cardiology

    Directory of Open Access Journals (Sweden)

    Davor Pavlin-Premrl

    2017-08-01

    Full Text Available Intracranial atherosclerosis is a major cause of ischemic stroke. Patients with a high degree of stenosis have a significant rate of stroke despite medical therapy. Two randomized trials of stenting have failed to show benefit. Improving periprocedural complication rates and patient selection may improve stenting outcomes. Fractional flow reserve (FFR, intravascular ultrasound (IVUS, and optical coherence tomography (OCT are intravascular imaging techniques employed to improve patient selection and stent placement in interventional cardiology. FFR has been shown to improve cardiovascular outcomes when used in patient selection for intervention. Studies of FFR in intracranial atherosclerosis show that the measure may predict which plaques lead to stroke. IVUS is used in cardiology to quantify stenosis and assist with stent placement. Comparisons with histology show that it can reliably characterize plaques. Several case reports of IVUS in intracranial arteries show the technique to be feasible and indicate it may improve stent placement. Plaque characteristics on IVUS may help identify vulnerable plaques. In interventional cardiology, OCT provides excellent visualization of vessel geometry and is useful periprocedurally. Images reliably identify thin-capped fibroatheromas and other plaque features. Case reports indicate that OCT is safe for use in intracranial arteries. OCT can be used to identify perforator vessels and so may be useful in avoiding perforator strokes, a common complication of stenting. Plaque characteristics on OCT may be useful in patient selection.

  1. Authority, Power and Reason of State in the Theater of Antonio Enríquez Gómez

    Directory of Open Access Journals (Sweden)

    Manuel Calderón Calderón

    2017-06-01

    Full Text Available Comedies of political content written by Antonio Enríquez Gómez reflect, through the analysis of its four recurring themes —the dichotomy between law and power, the reason of state, the law enforcement from a political point of view and forgiveness—, the outlines of the nascent Leviathan or modern state. Although the patriarchal relationship between the Monarch and his people is based on a iusnaturalist conception, love should be subject to the effectiveness in the exercise of power. The characters in this theatre sometimes hesitate between Aristotelian-Thomistic rationalism and Machiavellian-Hobbesian reason of state and, on other occasions, they oppose the people’s strength, risk and will to the divine reason of Law. In the context of the Hispanic Monarchy crisis, Enríquez Gómez’s critics are not limited to Government representatives and civil servants, but also include the Church and common people (Third State.

  2. El soñador de espigas lejanas de Antonio Colinas o la memoria de la poesía

    Directory of Open Access Journals (Sweden)

    Clara I. Martínez Cantón

    2017-08-01

    Full Text Available Este artículo propone una aproximación crítica al poema El soñador de espigas lejanas, publicado por Antonio Colinas a finales de 2013. Se identifican y analizan sus características más representativas: fragmentarismo, narración, historicismo, viaje interior y, sobre todo, su binarismo, de carácter simbólico. Su extensión y estos rasgos definitorios lo ligan al género del poema largo y, con él, a la tradición hispanoamericana, que ha dado grandes obras siguiendo esta forma poética. Se verán las similitudes y diferencias entre esta nueva composición y otras obras del autor. Es también objeto de estudio la manera de avanzar rítmicamente del poema.

  3. Ant and termite mound coinhabitants in the wetlands of Santo Antonio da Patrulha, Rio Grande do Sul, Brazil

    Directory of Open Access Journals (Sweden)

    E. Diehl

    Full Text Available This paper reports on ant and termite species inhabiting the mounds (murundus found in three wetland sites in Santo Antonio da Patrulha. Ants and termites were found in 100% of the mounds of two sites and in 20% of those in the third site. Colonies of Camponotus fastigatus were found inhabiting all the mounds, while colonies of Brachymyrmex sp., Linepithema sp., Pheidole sp., and/or Solenopsis sp. were collected in less than 30% of the mounds. In the mounds of the three sites, colonies of Anoplotermes sp. and/or Aparatermes sp. termites were found together with the ant colonies. Another cohabiting termite species, Cortaritermes sp., was found only in the mounds of one site. The results suggest that C. fastigatus is the species building the mounds, with the other species, whether ants or termites, being the inquilines.

  4. Ant and termite mound coinhabitants in the wetlands of Santo Antonio da Patrulha, Rio Grande do Sul, Brazil.

    Science.gov (United States)

    Diehl, E; Junqueira, L K; Berti-Filho, E

    2005-08-01

    This paper reports on ant and termite species inhabiting the mounds (murundus) found in three wetland sites in Santo Antonio da Patrulha. Ants and termites were found in 100% of the mounds of two sites and in 20% of those in the third site. Colonies of Camponotus fastigatus were found inhabiting all the mounds, while colonies of Brachymyrmex sp., Linepithema sp., Pheidole sp., and/or Solenopsis sp. were collected in less than 30% of the mounds. In the mounds of the three sites, colonies of Anoplotermes sp. and/or Aparatermes sp. termites were found together with the ant colonies. Another cohabiting termite species, Cortaritermes sp., was found only in the mounds of one site. The results suggest that C. fastigatus is the species building the mounds, with the other species, whether ants or termites, being the inquilines.

  5. SOME CLOSE UPS BETWEEN WORK, SCHOOL AND EDUCATION REGARDING THE PEDAGOGICAL AND POLITICAL CONSIDERATIONS BY ANTONIO GRAMSCI

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    Jefferson Carriello do Carmo

    2011-07-01

    Full Text Available The objective of this text are mainly two. First to emphasize some theorical questions regarding deep concepts and the proposed thematics as a way to rescue even in a brief and short path the general Picture of the concernings from Antonio Gramsci. Second, to verify that this subjects goes thru the political and ideological instances regarding the current elaboration called “Education as an Hegemony” . From this point on was noticed that the school proposition doesn´t represent a humane homesick tradicionalist overview and not even a technicist-professional aprouch but a new kind of interested school. In other words a more technicist and organic school in relation to the industrial modern world, based on scientific and technological principles made in a syntesis space between practice and theory, between handmade work and intelectual strenght. Key words: Education, work, politics, single school, industrialization.

  6. Antonio Quilis, La concodancia gramatiaal en Za Zengua espanola hablada en Madrid, C. S. I. C., Madrid 1983, pags. 128

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    Mitja Skubic

    1983-01-01

    Full Text Available El libra de Antonio Quilis, de poco más de cien páginas, nos ofrece los resultados de las encuestas sabre la concordancia sintáctica en el habla de Madrid. El Autor que es también cultivador y conocedor de la fonética del español­ pensemos en su importante trabajo sobre la fonética acústica de la lengua española (Gredos, Madrid 1981 - vuelve aqué a su vocacion de sintáctico, visible en sus trabajos sabre la estructura del español la edición de la Gramática de Nebri­ja y en el amor con que cuidó la presentación al mundo de habla castellana de las obras de B. Pottier.

  7. [Antonio de Saldanha da Gama's proposals to improve the slave trade "for humanitarian and economic reasons," Rio de Janeiro, 1810].

    Science.gov (United States)

    Viotti, Ana Carolina de Carvalho

    2016-01-01

    In 1808, Dom João VI issued an edict which regulated the shipping and treatment of slaves on the transatlantic crossing from Africa. Two years later, Antonio de Saldanha da Gama, a member of the Treasury Council, drafted a letter discussing some points of the resolution. This key figure in the Portuguese administration of Brazil argued that his respectful considerations concerning the determinations of His Royal Highness were designed to improve them "for humanitarian and economic reasons." Safeguarded in the archives of Arquivo Histórico Ultramarino, this letter is transcribed, annotated, and contextualized here, supplying an interesting perspective on the prevailing concerns and justifications about the trafficking of African slaves to Brazil.

  8. Antonio de Capmany and the city of Barcelona: the value of experience in the path of progress

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    Ramon GRAU I FERNÁNDEZ

    2017-02-01

    Full Text Available In his time, Antonio de Capmany (1742-1813 was the most prominent intellectual in the service of the interests of Barcelona, in a willingness to articulate the energy of that city with the efforts of enlightened despotism to relaunch Spain as a continental and colonial power. Extensive knowledge and assimilation of European culture of the Enlightenment allowed him to associate the historical experience of the Catalan capital with modern values. It was not a simple varnish, since the defense of Barcelona as the focus of progress was constructed from documented empirical data and sensory impressions, according to the principles preached by the great British philosophers against speculative rationalism and its incessant occurrences.

  9. Trajectories of neighborhood poverty and associations with subclinical atherosclerosis and associated risk factors: the multi-ethnic study of atherosclerosis.

    Science.gov (United States)

    Murray, Emily T; Diez Roux, Ana V; Carnethon, Mercedes; Lutsey, Pamela L; Ni, Hanyu; O'Meara, Ellen S

    2010-05-15

    The authors used data from the Multi-Ethnic Study of Atherosclerosis and latent trajectory class modeling to determine patterns of neighborhood poverty over 20 years (1980-2000 residential history questionnaires were geocoded and linked to US Census data). Using these patterns, the authors examined 1) whether trajectories of neighborhood poverty were associated with differences in the amount of subclinical atherosclerosis (common carotid intimal-media thickness) and 2) associated risk factors (body mass index, hypertension, diabetes, current smoking) at baseline (January 2000-August 2002). The authors found evidence of 5 stable trajectory groups with differing levels of neighborhood poverty ( approximately 6%, 12%, 20%, 30%, and 45%) and 1 group with 29% poverty in 1980 and approximately 11% in 2000. Mostly for women, higher cumulative neighborhood poverty was generally significantly associated with worse cardiovascular outcomes. Trends generally persisted after adjustment for adulthood socioeconomic position and race/ethnicity, although they were no longer statistically significant. Among women who had moved during the 20 years, the long-term measure had stronger associations with outcomes (except smoking) than a single, contemporaneous measure. Results indicate that cumulative 20-year exposure to neighborhood poverty is associated with greater cardiovascular risk for women. In residentially mobile populations, single-point-in-time measures underestimate long-term effects.

  10. Pycnogenol® and Centella asiatica in the management of asymptomatic atherosclerosis progression.

    Science.gov (United States)

    Belcaro, G; Ippolito, E; Dugall, M; Hosoi, M; Cornelli, U; Ledda, A; Scoccianti, M; Steigerwalt, R D; Cesarone, M R; Pellegrini, L; Luzzi, R; Corsi, M

    2015-04-01

    The aim of the study was to evaluate the effect of the nutritional supplements Pycnogenol® and total triterpenic fraction of Centella asiatica (TTFCA) on atherosclerosis progression in low-risk asymptomatic subjects with carotid or femoral stenosing plaques. This was an observational pilot, substudy of the San Valentino epidemiological cardiovascular study. The study included 824 subjects aged 45-60 without any conventional risk factors who had a stenosing atherosclerotic plaque (>50-60%) in at least one carotid or common femoral bifurcation, allocated into 6 groups: Group 1 (Controls): management was based on education, exercise, diet and lifestyle changes. This same management plan was used in all other groups; group 2: Pycnogenol® 50 mg/day; group 3: Pycnogenol® 100 mg/day; group 4: Aspirin® 100 mg/day or ticlopidine 250 mg/day if intolerant to aspirin; group 5: Aspirin® 100 mg/day and Pycnogenol® 100 mg/day; group 6: Pycnogenol® 100 mg/day plus TTFCA 100 mg/day. The follow-up lasted 42 months. Plaque progression was assessed using the ultrasonic arterial score based on the arterial wall morphology and the number of plaques that progressed and on the number of subjects that had cardiovascular events. A secondary endpoint was to evaluate the changes in oxidative stress at baseline and at 42 months. The ultrasonic score increased significantly in groups 1, 2, and 4 (>1%) but not in groups 3, 5 and 6 (Events (hospital admission, specialized care) were observed in 16.03% of controls; there were 8.83% of subjects with events with Pycnogenol® 50 mg and 8% in group 3 (Pycnogenol® 100 mg). In group 4 (antiplatelets), 8.52% of subjects had events; in group 5, 6.87% of subjects had events and in group 6 (TTFCA+ Pycnogenol®) only 4.41% had events (this was the lowest event rate; Pevent rate (Pmanagement in comparison with controls. The need for risk factor management was higher in controls and lower in group 6 (Pmanagement was lower than in controls (Pevents

  11. Effects of intra-abdominal sepsis on atherosclerosis in mice.

    Science.gov (United States)

    Kaynar, Ata Murat; Yende, Sachin; Zhu, Lin; Frederick, Daniel R; Chambers, Robin; Burton, Christine L; Carter, Melinda; Stolz, Donna Beer; Agostini, Brittani; Gregory, Alyssa D; Nagarajan, Shanmugam; Shapiro, Steven D; Angus, Derek C

    2014-09-03

    Sepsis and other infections are associated with late cardiovascular events. Although persistent inflammation is implicated, a causal relationship has not been established. We tested whether sepsis causes vascular inflammation and accelerates atherosclerosis. We performed prospective, randomized animal studies at a university research laboratory involving adult male ApoE-deficient (ApoE-/-) and young C57B/L6 wild-type (WT) mice. In the primary study conducted to determine whether sepsis accelerates atherosclerosis, we fed ApoE-/- mice (N = 46) an atherogenic diet for 4 months and then performed cecal ligation and puncture (CLP), followed by antibiotic therapy and fluid resuscitation or a sham operation. We followed mice for up to an additional 5 months and assessed atheroma in the descending aorta and root of the aorta. We also exposed 32 young WT mice to CLP or sham operation and followed them for 5 days to determine the effects of sepsis on vascular inflammation. ApoE-/- mice that underwent CLP had reduced activity during the first 14 days (38% reduction compared to sham; P < 0.001) and sustained weight loss compared to the sham-operated mice (-6% versus +9% change in weight after CLP or sham surgery to 5 months; P < 0.001). Despite their weight loss, CLP mice had increased atheroma (46% by 3 months and 41% increase in aortic surface area by 5 months; P = 0.03 and P = 0.004, respectively) with increased macrophage infiltration into atheroma as assessed by immunofluorescence microscopy (0.52 relative fluorescence units (rfu) versus 0.97 rfu; P = 0.04). At 5 months, peritoneal cultures were negative; however, CLP mice had elevated serum levels of interleukin 6 (IL-6) and IL-10 (each at P < 0.05). WT mice that underwent CLP had increased expression of intercellular adhesion molecule 1 in the aortic lumen versus sham at 24 hours (P = 0.01) that persisted at 120 hours (P = 0.006). Inflammatory and adhesion genes (tumor necrosis factor α, chemokine (C-C motif) ligand 2

  12. [Homocystein serum levels and lipid parameters in children with atherosclerosis risk factors].

    Science.gov (United States)

    Sierakowska-Fijałek, Anna; Kaczmarek, Piotr; Pokoca, Lech; Smorag, Ireneusz; Wosik-Erenbek, Marzenna; Baj, Zbigniew

    2007-02-01

    Atherosclerosis is a disease of adult patients, however, it begins in childhood and progresses from fatty streaks to raised lesions in arteries in adolescence and young adults. Clinical manifestation of atherosclerosis in adulthood depends on the risk factors such as: lipid disorders, obesity, hypertension, smoking habits and family history of CHD. High serum homocysteine concentration is increasingly recognised as a new risk factor for atherosclerosis and other vascular diseases. Atherogenic effect of homocystein is related to cytotoxin action on the endothelial cells and their function. The aim of this study was to estimate relations between the homocysteine serum concentration and the lipid levels in children with atherosclerosis risk factors. The study was carried out on 48 children with atherosclerosis risk factors. The control group consisted of 25 healthy childrens. Total cholesterol (TC), Triglycerides (TG), HDL-C, LDL-C were determined by enzymatic method. Concentration of homocysteine was estimated by immunoenzymatic method (ELISA). Obesity, lipid disorders, and hypertension were the most frequent risk factors in the investigated children. Statistically significant higher concentration of TC, LDL-C, TG and lower HDL-C were observed in children with atherosclerosis risk factors. No significant differences in homocystein concentration were observed in the investigated groups, but homocystein concentration was significantly higher in group of children with atherosclerosis risk factors. We observed that increased number of the risk factors is followed by high homocystein concentration in the serum.

  13. A review of plant-based compounds and medicinal plants effective on atherosclerosis

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    Mehrnoosh Sedighi

    2017-01-01

    Full Text Available Atherosclerosis is one of the most important cardiovascular diseases that involve vessels through the development of fatty streaks and plaques. Plant-based compounds can help treat or prevent atherosclerosis through affecting the involved factors. The main purpose of this review article is to investigate and introduce medicinal plants and their potential activities regarding antioxidant properties, effective on lipids level and development of plaque, atherosclerosis, and progression of atherosclerosis as well as the development of cardiovascular disease and ischemia. To search for the relevant articles indexed in Information Sciences Institute, PubMed, Scientific Information Database, IranMedex, and Scopus between 1980 and 2013, with further emphasis on those indexed from 2004 to 2015, we used these search terms: atherosclerosis, antioxidant, cholesterol, inflammation, and the medicinal plants below. Then, the articles with inclusion criteria were used in the final analysis of the findings. Plant-based active compounds, including phenols, flavonoids, and antioxidants, can be effective on atherosclerosis predisposing factors and hence in preventing this disease and associated harmful complications, especially through reducing cholesterol, preventing increase in free radicals, and ultimately decreasing vascular plaque and vascular resistance. Hence, medicinal plants can contribute to treating atherosclerosis and preventing its progression through reducing cholesterolemia, free radicals, inflammation, vascular resistance, and certain enzymes. They, alone or in combination with hypocholesterolemic drugs, can therefore be useful for patients with hyperlipidemia and its complications.

  14. Enhanced Preliminary Assessment Report: Presidio of San Francisco Military Reservation, San Francisco, California

    Science.gov (United States)

    1989-11-01

    CAD981415656 Filmore Steiner Bay San Francisco 24 PG&E Gas Plant SanFran 502-IG CAD981415714 Bay North Point Buchanan Laguna 25 PG&E Gas Plant SanFran 502-1H...76-ioV /5,JO /0.7 /,230 PSF Water PSF, Main U.N. Lagunda Honda Analvte Plant Clearwell Reservoir Plaza Reservoi- Chlordane inetab. ə.2 ə.2 (1.2 ə.2

  15. A case for historic joint rupture of the San Andreas and San Jacinto faults

    OpenAIRE

    Lozos, Julian C.

    2016-01-01

    The San Andreas fault is considered to be the primary plate boundary fault in southern California and the most likely fault to produce a major earthquake. I use dynamic rupture modeling to show that the San Jacinto fault is capable of rupturing along with the San Andreas in a single earthquake, and interpret these results along with existing paleoseismic data and historic damage reports to suggest that this has likely occurred in the historic past. In particular, I find that paleoseismic data...

  16. «Un esclavo que se llama Antonio»: venta de dos esclavos asiáticos en Galicia a inicios del siglo XVII

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    Ménard, Caroline

    2012-12-01

    Full Text Available Slavery has existed in the Iberian Peninsula since the Antiquity and up to the Modern Era - and moreover, it was not restricted to the submission of people coming from Africa. This paper will look at the sale of two slaves originally from Asia, Antonio and Domingo, in 1603 in the port of Vigo - it will explore their journey, the role of the Carreira da India Portuguese mariners as sailors, their origin and sale price. Antonio and Domingo might represent a minority compared to all the slaves living at that time in Galicia, but their difference is a rich illustration of the process as it was then working.

    La esclavitud era conocida en la Península Ibérica desde la Antigüedad y durante la Época Moderna y no se limitó a la sumisión de personas de origen africana. Este artículo trata de la venta de dos esclavos de origen asiático, Antonio y Domingo, en el puerto de Vigo en 1603; en él se analiza la ruta emprendida por éstos, el papel desempeñado por los marineros portugueses de la Carreira da India como vendedores, así como su origen y precio. Antonio y Domingo representan una minoria dentro del conjunto de los esclavos viviendo en ese momento en Galicia, pero su presencia es un ejemplo ilustrativo de la dinámica vigente en la época. [gl] A escravitude era coñecida na Península Ibérica dende a Antigüidade e durante a Época Moderna e non se limitou a sumisión de persoas de orixe africana. Este artigo trata da venda de dous escravos de orixe asiática, Antonio e Domingo, no porto de Vigo no 1603. No artigo analízase a ruta realizada por estes e a súa orixe e prezo, así como o papel xogado polos mariñeiros portugueses na Carreira da India como vendedores. Antonio y Domingo representan unha corrente minoritaria dentro do conxunto dos escravos que viven en Galicia nesta época, mais a sua presencia é un bon exemplo da dinamica vivida nesta época.

  17. Osteocalcin expression by circulating endothelial progenitor cells in patients with coronary atherosclerosis.

    Science.gov (United States)

    Gössl, Mario; Mödder, Ulrike I; Atkinson, Elizabeth J; Lerman, Amir; Khosla, Sundeep

    2008-10-14

    This study was designed to test whether patients with coronary atherosclerosis have increases in circulating endothelial progenitor cells (EPCs) expressing an osteogenic phenotype. Increasing evidence indicates a link between bone and the vasculature, and bone marrow and circulating osteogenic cells have been identified by staining for the osteoblastic marker, osteocalcin (OCN). Endothelial progenitor cells contribute to vascular repair, but repair of vascular injury may result in calcification. Using cell surface markers (CD34, CD133, kinase insert domain receptor [KDR]) to identify EPCs, we examined whether patients with coronary atherosclerosis had increases in the percentage of EPCs expressing OCN. We studied 72 patients undergoing invasive coronary assessment: control patients (normal coronary arteries and no endothelial dysfunction, n = 21) versus 2 groups with coronary atherosclerosis-early coronary atherosclerosis (normal coronary arteries but with endothelial dysfunction, n = 22) and late coronary atherosclerosis (severe, multivessel coronary artery disease, n = 29). Peripheral blood mononuclear cells were analyzed using flow cytometry. Compared with control patients, patients with early or late coronary atherosclerosis had significant increases (approximately 2-fold) in the percentage of CD34+/KDR+ and CD34+/CD133+/KDR+ cells costaining for OCN. Even larger increases were noted in the early and late coronary atherosclerosis patients in the percentage of CD34+/CD133-/KDR+ cells costaining for OCN (5- and 2-fold, p < 0.001 and 0.05, respectively). A higher percentage of EPCs express OCN in patients with coronary atherosclerosis compared with subjects with normal endothelial function and no structural coronary artery disease. These findings have potential implications for the mechanisms of vascular calcification and for the development of novel markers for coronary atherosclerosis.

  18. Recent advances in lipoprotein and atherosclerosis: A nutrigenomic approach

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    López, Sergio

    2009-03-01

    Full Text Available Atherosclerosis is a disease in which multiple factors contribute to the degeneration of the vascular wall. Many risk factors have been identified as having influence on the progression of atherosclerosis among them, the type of diet. Multifactorial interaction among lipoproteins, vascular wall cells, and inflammatory mediators has been recognised as the basis of atherogenesis. Dietary intake affects lipoprotein concentration and composition providing risk or protection at several stages of atherosclerosis. More intriguingly, it has been demonstrated that the extent to which each lipid or lipoprotein is associated with cardiovascular disease depends on the time to last meal; thus, postprandial lipoproteins, main lipoproteins in blood after a high-fat meal, have been shown to strongly influence atherogenesis. As a complex biological process, the full cellular and molecular characterization of atherosclerosis derived by diet, calls for application of the newly developing “omics” techniques of analysis. This review will considered recent studies using high-throughput technologies and a nutrigenomic approach to reveal the patho-physiological effects that the fasting and postprandial lipoproteins may exert on the vascular wall.La aterosclerosis es una enfermedad en la que múltiples factores, entre los que se encuentra la dieta, contribuyen a la degradación de la pared vascular. En la etiología de la aterogénesis son determinantes las lipoproteínas plasmáticas y los distintos tipos celulares de la pared vascular, incluyendo una respuesta inflamatoria. La ingesta de alimentos afecta la concentración y composición de las lipoproteínas, ejerciendo un papel de riesgo o protector durante las diferentes etapas del proceso aterosclerótico. Es importante destacar que la naturaleza de las lipoproteínas y por lo tanto su papel en la enfermedad cardiovascular, también depende del tiempo transcurrido entre comidas. Por ejemplo, las lipoprote

  19. Is zinc deficiency a risk factor for atherosclerosis?

    Science.gov (United States)

    Beattie, John H; Kwun, In-Sook

    2004-02-01

    The development of atherosclerosis is influenced by genetic, lifestyle and nutritional risk factors. Zn and metallothionein deficiency can enhance oxidative-stress-related signalling processes in endothelial cells, and since changes in available plasma Zn may affect the Zn status of the endothelium, Zn deficiency could be a risk factor for IHD. Although the association of Zn with many proteins is essential for their function, three key signalling processes are highlighted as being principal targets for the effect of Zn deficiency: the activation of NF-kappaB, the activation of caspase enzymes and the signalling of NO. The need to develop a reliable indicator of Zn status is critical to any epidemiological approach for studying the relationship between Zn status and disease incidence. Studies using appropriate animal models and investigating how the plasma Zn pool influences endothelial intracellular labile Zn would be helpful in appreciating the importance of Zn deficiency in atherogenesis.

  20. [Optimization of organizational approaches to management of patients with atherosclerosis].

    Science.gov (United States)

    Barbarash, L S; Barbarash, O L; Artamonova, G V; Sumin, A N

    2014-01-01

    Despite undoubted achievements of modern cardiology in prevention and treatment of atherosclerosis, cardiologists, neurologists, and vascular surgeons are still facing severe stenotic atherosclerotic lesions in different vascular regions, both symptomatic and asymptomatic. As a rule hemodynamically significant stenoses of different locations are found after development of acute vascular events. In this regard, active detection of arterial stenoses localized in different areas just at primary contact of patients presenting with symptoms of ischemia of various locations with care providers appears to be crucial. Further monitoring of these stenoses is also important. The article is dedicated to innovative organizational approaches to provision of healthcare to patients suffering from circulatory system diseases that have contributed to improvement of demographic situation in Kuzbass.