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Sample records for atf advanced toroidal

  1. Fabrication of the helical field coil components for the advanced toroidal facility

    Energy Technology Data Exchange (ETDEWEB)

    Cole, M.J.; Whitson, J.C.; Banks, B.J.

    1987-01-01

    The fabrication techniques used to manufacture the major components of the helical field (HF) coil segments for the Advanced Toroidal Facility (ATF) are described. The major components of an HF coil segment are 14 water-cooled, copper conductors and a T-shaped stainless steel support member (or ''tee''). Twenty-four of these segments were used in the fabrication of two coils for the ATF experiment. The helical shape, accurate position requirements, large size, and potential for high cost required unique approaches to the fabrication of these components. One method of fabrication was to use 44-mm-thick (standard size) plate to form the base and leg of the tee and to join the sections by welding. Because of the tolerance requirements, a thicker plate (70 mm) was used and then contour machined to the final shape. The second approach, conducted in parallel with the first, was to cast the tee as a single piece. The first attempts were to make the casting larger than required, then machine it to final size and shape. The cost of machining either the welded tee or the cast tee was extremely high, so several prototypes were fabricated until a cast tee that required no contour machining was produced. The shape and positional requirements were also the major problems in fabricating the copper conductors, or turns. The approach taken was to make an accurate fixture and position the turns in the fixture, then anneal to remove residual stresses and form the copper turns to the shape of the fixture. The lessons learned in pursuing these fabrication methods are presented. 5 refs., 3 figs.

  2. ATF2 COMMISSIONING

    CERN Document Server

    Seryi, A; Parker, B; Schulte, D; Delahaye, J P; Tomas, R; Zimmermann, F; Wolski, A; Elsen, E; Sanuki, T; Gianfelice-Wendt, E; Ross, M; Wendt, M; Takahashi, T; Bai, S; Gao, J; Bolzon, B; Geffroy, N; Jeremie, A; Apsimon, R; Burrows, P; Constance, B; Perry, C; Resta-Lopez, J; Swinson, C; Araki, S; Aryshev, A; Hayano, H; Honda, Y; Kubo, K; Kume, T; Kuroda, S; Masuzawa, M; Naito, T; Okugi, T; Sugahara, R; Tauchi, T; Terunuma, N; Urakawa, J; Yokoya, K; Iwashita, Y; Sugimoto, T; Heo, A Y; Kim, E S; Kim, H S; Bambade, P; Renier, Y; Rimbault, C; Huang, J Y; Kim, S H; Park, Y J; Hwang, W H; Blair, G; Boogert, S; Karataev, P; Molloy, S; Amann, J; Bellomo, P; Lam, B; McCormick, D; Nelson, J; Paterson, E; Pivi, M; Raubenheimer, T; Spencer, C; Wang, M H; White, G; Wittmer, W; Woodley, M; Yan, Y; Zhou, F; Angal-Kalinin, D; Jones, J; Lyapin, A; Scarfe, A; Kamiya, Y; Komamiya, S; Oroku, M; Suehara, T; Yamanaka, T

    2010-01-01

    ATF2 is a final-focus test beam line that aims to focus the low-emittance beam from the ATF damping ring to a beam size of about 37 nm, and at the same time to demonstrate nm beam stability, using numerous advanced beam diagnostics and feedback tools. The construction has been finished at the end of 2008 and the beam commissioning of ATF2 has started in December of 2008. ATF2 is constructed and commissioned by ATF international collaborations with strong US, Asian and European participation.

  3. ATF2 Commissioning

    Energy Technology Data Exchange (ETDEWEB)

    Seryi, A.; /SLAC; Christian, G.; /KLTE-ATOMKI; Parker, B.; /BNL; Schulte, D.; Delahaye, J.-P.; Tomas, R.; Zimmermann, F.; /CERN; Wolski, A.; Elsen, E.; /Cockcroft Inst. /DESY; Sanuki, T.; /Tohoku U.; Gianfelice-Wendt, E.; Ross, M.; Wendt, M.; /Fermilab; Takahashi, T.; /Hiroshima U.; Bai, S.; Gao, J.; /Beijing, Inst. High Energy Phys.; Bolzon, B.; Geffroy, N.; Jeremie, A.; /Annecy, LAPP; Apsimon, R.; Burrows, P.; /Oxford U., JAI /Kyoto U., Inst. Chem. Res. /Kyungpook Natl. U. /Orsay, LAL /Phang Accelerator Lab /Royal Holloway, U. of London /SLAC /Daresbury /University Coll. London /Manchester U. /Univ. of Tokyo U.

    2009-10-30

    ATF2 is a final-focus test beam line that aims to focus the low-emittance beam from the ATF damping ring to a beam size of about 37 nm, and at the same time to demonstrate nm beam stability, using numerous advanced beam diagnostics and feedback tools. The construction has been finished at the end of 2008 and the beam commissioning of ATF2 has started in December of 2008. ATF2 is constructed and commissioned by ATF international collaborations with strong US, Asian and European participation.

  4. A Experimental Study of Ion Behavior in the Advanced Toroidal Facility

    Science.gov (United States)

    Wade, Mickey Ray

    Stellarators represent one of the most promising magnetic confinement concepts for a fusion reactor because of their intrinsic ability to operate at steady state, though legitimate concerns about various aspects of the stellarator concept must be addressed. One of these concerns is the seemingly unfavorable single-particle confinement properties inherent to the stellarator design. Although previous experimental studies of ion confinement in stellarators have indicated that the ions behave classically and are generally well confined, these studies were limited in scope. To complement these experiments and to provide additional information about ion behavior in stellarators, an experimental investigation of ion behavior has been performed on the Advanced Toroidal Facility (ATF). Measurements were made of both the thermal- and fast-ion distributions during electron cyclotron heating (ECH) and neutral beam injection (NBI). The purpose of this work was to study thermal- and fast-ion confinement in ATF with particular emphasis placed on constructing a consistent picture of ion confinement based on experimentally measured data. The primary ion diagnostic used in these studies was a two -dimensional scanning neutral particle analyzer (NPA). Extensive studies of fast-ion behavior in various operating regimes on ATF were conducted. These studies were performed during NBI and encompass a wide range of plasma densities, ranging from extremely low density ( |{n}_{e} =q 8.0 times 10^ {13} cm^{-3}) . Fokker-Planck simulations of the measured data suggest that the injected ions behave classically and indicate that the injected beam power is not well absorbed at low and intermediate densities because of large charge-exchange and shine-through losses. Further simulations using the PROCTR transport analysis code indicate that this reduced absorption is probably the cause of the thermal collapse observed in intermediate-density NBI discharges. Thermal ion confinement studies were

  5. Thermal and electrical joint test for the helical field coils in the Advanced Toroidal Facility

    Energy Technology Data Exchange (ETDEWEB)

    Brown, R.L.; Johnson, R.L.

    1985-01-01

    Initial feasibility studies of a number of configurations for the Advanced Toroidal Facility (ATF) resulted in the selection of a resistive copper continuous-coil torsatron as the optimum device considering the physics program, cost, and schedule. Further conceptual design work was directed toward optimization of this configuration and, if possible, a shorter schedule. It soon became obvious that in order to shorten the schedule, a number of design and fabrication activities should proceed in parallel. This was most critical for the vacuum vessel and the helical field (HF) coils. If the HF coils were wound in place on a completed vacuum vessel, the overall schedule would be significantly (greater than or equal to12 months) longer. The approach of parallel scheduel paths requires that the HF coils be segmented into parts of less than or equal to180 of poloidal angle and that joints be made on a turn-by-turn basis when the segments are installed. It was obvious from the outset that the compact and complex geometry of the joint design presented a special challenge in the areas of reliability, assembly, maintenance, disassembly, and cost. Also, electrical, thermal, and force excursions are significant for these joints. A number of soldered, welded, brazed, electroplated, and bolted joints were evaluated. The evaluations examined fabrication feasibility and complexity, thermal-electrical performance at approximately two-thirds of the steady-state design conditions, and installation and assembly processes. Results of the thermal-electrical tests were analyzed and extrapolated to predict performance at peak design parameters. The final selection was a lap-type joint clamped with insulated bolts that pass through the winding packing. 3 refs., 4 figs.

  6. Advances on the Brazilian toroidal grating monochromator (TGM) beamline

    Energy Technology Data Exchange (ETDEWEB)

    Cavasso Filho, R.L. [Laboratorio Nacional de Luz Sincrotron, Box 6192, Campinas, SP 13084-971 (Brazil); Homem, M.G.P. [Laboratorio Nacional de Luz Sincrotron, Box 6192, Campinas, SP 13084-971 (Brazil); Landers, R. [Instituto de Fisica ' Gleb Wataghin' , Universidade Estadual de Campinas, Box 6165, Campinas, SP 13083-970 (Brazil); Naves de Brito, A. [Laboratorio Nacional de Luz Sincrotron, Box 6192, Campinas, SP 13084-971 (Brazil)]. E-mail: arnaldo@lnls.br

    2005-06-15

    We report on an important advance for the vacuum ultraviolet and soft X-ray TGM beamline at Laboratorio Nacional de Luz Sincrotron (LNLS). This beamline provides photons in the energy range 12-330 eV using three gratings. It is well known that TGMs deliver relatively high flux at these energies but harmonic contamination can be a serious problem. Of special interest for the users is the range between 12 and 21 eV covered by one of the gratings for studies of outer and inner valence ionization processes in gases as well as solids. Here, we report a solution to the harmonic contamination problems based on a noble gas phase filter combined with thin metal foil barriers.

  7. Advances in the simulation of toroidal gyro Landau fluid model turbulence

    Energy Technology Data Exchange (ETDEWEB)

    Waltz, R.E. [General Atomics, San Diego, CA (United States); Kerbel, G.D.; Milovich, J. [Lawrence Livermore National Lab., CA (United States); Hammett, G.W. [Princeton Univ., NJ (United States). Plasma Physics Lab.

    1994-12-01

    The gyro-Landau fluid (GLF) model equations for toroidal geometry have been recently applied to the study ion temperature gradient (ITG) mode turbulence using the 3D nonlinear ballooning mode representation (BMR). The present paper extends this work by treating some unresolved issues conceming ITG turbulence with adiabatic electrons. Although eddies are highly elongated in the radial direction long time radial correlation lengths are short and comparable to poloidal lengths. Although transport at vanishing shear is not particularly large, transport at reverse global shear, is significantly less. Electrostatic transport at moderate shear is not much effected by inclusion of local shear and average favorable curvature. Transport is suppressed when critical E{times}B rotational shear is comparable to the maximum linear growth rate with only a weak dependence on magnetic shear. Self consistent turbulent transport of toroidal momentum can result in a transport bifurcation at suffciently large r/(Rq). However the main thrust of the new formulation in the paper deals with advances in the development of finite beta GLF models with trapped electron and BMR numerical methods for treating the fast parallel field motion of the untrapped electrons.

  8. BNL ATF II beamlines design

    Energy Technology Data Exchange (ETDEWEB)

    Fedurin, M. [Brookhaven National Lab. (BNL), Upton, NY (United States); Jing, Y. [Brookhaven National Lab. (BNL), Upton, NY (United States); Stratakis, D. [Brookhaven National Lab. (BNL), Upton, NY (United States); Swinson, C. [Brookhaven National Lab. (BNL), Upton, NY (United States)

    2015-05-03

    The Brookhaven National Laboratory. Accelerator Test Facility (BNL ATF) is currently undergoing a major upgrade (ATF-II). Together with a new location and much improved facilities, the ATF will see an upgrade in its major capabilities: electron beam energy and quality and CO2 laser power. The electron beam energy will be increased in stages, first to 100-150 MeV followed by a further increase to 500 MeV. Combined with the planned increase in CO2 laser power (from 1-100 TW), the ATF-II will be a powerful tool for Advanced Accelerator research. A high-brightness electron beam, produced by a photocathode gun, will be accelerated and optionally delivered to multiple beamlines. Besides the energy range (up to a possible 500 MeV in the final stage) the electron beam can be tailored to each experiment with options such as: small transverse beam size (<10 um), short bunch length (<100 fsec) and, combined short and small bunch options. This report gives a detailed overview of the ATFII capabilities and beamlines configuration.

  9. ATF2 Proposal

    Energy Technology Data Exchange (ETDEWEB)

    Grishanov, Boris Ivanovich; Logachev, Pavel; Podgorny, Fedor; Telnov, Valery; /Novosibirsk, IYF; Angal-Kalinin, Deepa; Appleby, Robert; Jones, James; Kalinin, Alexander; /Daresbury; Napoly, Olivier; Payet, Jacques; /DAPNIA, Saclay; Braun, Hans-Heinrich; Schulte, Daniel; Zimmermann, Frank; /CERN; Barlow, Roger; Bailey, Ian; Jenner, Leo; Jones, Roger; Kourevlev, German; /Daresbury; Walker, Nick; /DESY; Takahasi, Tohru; /Hiroshima U.; Gao, Jie; /Beijing, Inst. High Energy Phys. /Oxford U. /KEK, Tsukuba /Kyoto U., Inst. Chem. Res.

    2005-08-23

    This document is the first of two volumes describing the ATF2 project. The present volume discusses the technical justification for ATF2 and presents a design description. Since the International Committee for Future Accelerator (ICFA) decision on the choice of technology, a world-wide collaboration on the design of the International Linear Collider (ILC) has rapidly progressed [1]. The formation of the Global Design Effort (GDE) will accelerate the work towards a final design. An important technical challenge is obviously the high gradient acceleration but what is similarly challenging is the collision of extremely small beams of a few nanometer size. The latter challenge has three distinct issues: creating small emittance beams, preserving the emittance during acceleration and transport, and focusing the beams to nanometers. Most studies have been done using computer simulations but many issues still remain that require experimental verification. Accelerator Test Facility (ATF) at KEK was built to create small emittance beams, and succeeded in obtaining an emittance that almost satisfies the ILC requirements [2]. In this proposal we present a project, ATF2, which addresses the focusing of the beam into a nanometer spot. The ATF2 project will extend the extraction beamline of the ATF with an ILC-type final focus system to create a tightly focused, stable beam by making use of the small emittance of the ATF. The layout is shown in Figure 1.1. In the longer term, the ATF2 project would also provide invaluable input for the CLIC design of a future multi-TeV collider.

  10. A cytoplasmic negative regulator isoform of ATF7 impairs ATF7 and ATF2 phosphorylation and transcriptional activity.

    Science.gov (United States)

    Diring, Jessica; Camuzeaux, Barbara; Donzeau, Mariel; Vigneron, Marc; Rosa-Calatrava, Manuel; Kedinger, Claude; Chatton, Bruno

    2011-01-01

    Alternative splicing and post-translational modifications are processes that give rise to the complexity of the proteome. The nuclear ATF7 and ATF2 (activating transcription factor) are structurally homologous leucine zipper transcription factors encoded by distinct genes. Stress and growth factors activate ATF2 and ATF7 mainly via sequential phosphorylation of two conserved threonine residues in their activation domain. Distinct protein kinases, among which mitogen-activated protein kinases (MAPK), phosphorylate ATF2 and ATF7 first on Thr71/Thr53 and next on Thr69/Thr51 residues respectively, resulting in transcriptional activation. Here, we identify and characterize a cytoplasmic alternatively spliced isoform of ATF7. This variant, named ATF7-4, inhibits both ATF2 and ATF7 transcriptional activities by impairing the first phosphorylation event on Thr71/Thr53 residues. ATF7-4 indeed sequesters the Thr53-phosphorylating kinase in the cytoplasm. Upon stimulus-induced phosphorylation, ATF7-4 is poly-ubiquitinated and degraded, enabling the release of the kinase and ATF7/ATF2 activation. Our data therefore conclusively establish that ATF7-4 is an important cytoplasmic negative regulator of ATF7 and ATF2 transcription factors.

  11. A cytoplasmic negative regulator isoform of ATF7 impairs ATF7 and ATF2 phosphorylation and transcriptional activity.

    Directory of Open Access Journals (Sweden)

    Jessica Diring

    Full Text Available Alternative splicing and post-translational modifications are processes that give rise to the complexity of the proteome. The nuclear ATF7 and ATF2 (activating transcription factor are structurally homologous leucine zipper transcription factors encoded by distinct genes. Stress and growth factors activate ATF2 and ATF7 mainly via sequential phosphorylation of two conserved threonine residues in their activation domain. Distinct protein kinases, among which mitogen-activated protein kinases (MAPK, phosphorylate ATF2 and ATF7 first on Thr71/Thr53 and next on Thr69/Thr51 residues respectively, resulting in transcriptional activation. Here, we identify and characterize a cytoplasmic alternatively spliced isoform of ATF7. This variant, named ATF7-4, inhibits both ATF2 and ATF7 transcriptional activities by impairing the first phosphorylation event on Thr71/Thr53 residues. ATF7-4 indeed sequesters the Thr53-phosphorylating kinase in the cytoplasm. Upon stimulus-induced phosphorylation, ATF7-4 is poly-ubiquitinated and degraded, enabling the release of the kinase and ATF7/ATF2 activation. Our data therefore conclusively establish that ATF7-4 is an important cytoplasmic negative regulator of ATF7 and ATF2 transcription factors.

  12. ATF2 Proposal v. 2

    CERN Document Server

    Grishanov, B I; Alabau-Pons, M; Angal-Kalinin, Deepa; Appleby, R; Araki, S; Bailey, I; Bambade, P; Bane, Karl Leopold Freitag; Barlow, R; Blair, G A; Bolzon, B; Boorman, G; Bosco, A; Brachmann, A; Braun, Hans Heinrich; Burrows, P N; Carter, J; Choi, J; Christian, Glenn B; Clarke, C; Dabiri-Khah, A; Dadoun, O; Danagulyan, S; Delerue, N; Dixit, S; Driouichi, C; Elsen E; Gao, J; Geffroy, N; Gronberg, J; Hartin, Anthony F; Hayano, H; Higashi, Y; Himel, T; Honda, Y; Howell, D; Huang, J Y; Iwashita, Y; Jenner, L; Jones, J; Jones, R; Jérémie, A; Kalinin, A; Kanazawa, K; Kang, H S; Karyotakis, Yu; Kim, E S; Kim, S; Komamiya, S; Kourevlev, German Yu; Kubo, K; Kumada, M; Kume, T; Kuriki, M; Kuroda, S; Liu, W; Logatchev, P V; Lyapin, A; Malton, S; Markiewicz, T W; Masuzawa, M; Mihara, T; Miller, D J; Molloy, S; Mtingwa, S; Naito, T; Nan-Phinney, Y; Napoly, O; Nelson, J; Okugi, T; Payet, J; Pei, G X; Pivi, M T F; Podgorny, F; Price, M; Raubenheimer, T O; Reichold, A; Ross, M; Sanuki, T; Schulte, Daniel; Seryi, R A; Solyak, N; Soo Ko In; Spencer, C M; Suehara, T; Sugahara, R; Takahashi, T; Takashi-Boogert, S; Tauchi, T; Telnov, Valery I; Tenenbaum, P G; Terunuma, N; Toge, N; Torrence, E; Urakawa, J; Urner, D; Vogel, V; Walker, N; Wang, J Q; Wendt, M; White, G; Wing, M; Wolski, A; Woodley, M; Yamaoka, H; Yokoya, K; Zimmermann, Frank

    2006-01-01

    For achieving the high luminosity required at the International Linear Collider (ILC), it is critical to focus the beams to nanometer size with the ILC Beam Delivery System (BDS), and to maintain the beam collision with a nanometer-scale stability. To establish the technologies associated with this ultra-high precision beam handling, it has been proposed to implement an ILC-like final focus optics in an extension of the existing extraction beamline of ATF at KEK. The ATF is considered to be the best platform for this exercise, since it provides an adequate ultra-low emittance electron beam in a manner dedicated to the development of ILC. The two major goals for this facility, called ATF2, are : (A) Achievement of a 37 nm beam size, and (B) control of beam position down to 2 nm level. The scientific justification for the ATF2 project and its technical design have been described in Volume 1 of the ATF2 Proposal [1]. We present here Volume 2 of the ATF2 Proposal, in which we present specifics of the construction...

  13. Sensing with toroidal metamaterial

    Science.gov (United States)

    Gupta, Manoj; Srivastava, Yogesh Kumar; Manjappa, Manukumara; Singh, Ranjan

    2017-03-01

    Localized electromagnetic excitation in the form of toroidal dipoles has recently been observed in metamaterial systems. The origin of the toroidal dipole lies in the currents flowing on the surface of a torus. Thus, the exotic toroidal excitations play an important role in determining the optical properties of a system. Toroidal dipoles also contribute towards enabling high quality factor subwavelength resonances in metamaterial systems which could be an excellent platform for probing the light matter interaction. Here, we demonstrate sensing with toroidal resonance in a two-dimensional terahertz metamaterial in which a pair of mirrored asymmetric Fano resonators possesses anti-aligned magnetic moments at an electromagnetic resonance that gives rise to a toroidal dipole. Our proof of concept demonstration opens up an avenue to explore the interaction of matter with toroidal multipoles that could have strong applications in the sensing of dielectrics and biomolecules.

  14. Status of the ATF2 Lattices

    Energy Technology Data Exchange (ETDEWEB)

    Marin, E.; Tomas, R.; /CERN; Bambade, P.; /Orsay, LAL; Okugi, T.; Tauchi, T.; Terunuma, N.; Urakawa, J.; /KEK, Tsukuba; Seryi, A.; /Oxford U., JAI; White, G.; Woodley, M.; /SLAC

    2011-12-09

    The current status for the ATF2 Nominal and Ultra-low {beta}* lattices are presented in this paper. New lattice designs have been obtained in order to minimise the impact of the last interpretation of multipole measurements that have been included into the model. However, the new ATF2 Ultra-low design is not able to recover the expected vertical beam size at the IP with the current magnet distribution. Therefore, different quadrupole sorting have been studied. A significant gain is evident for the ATF2 Ultra-low lattice when sorting the magnets according to the skew-sextupolar components. The ATF2 Nominal lattice is also expected to benefit from the new sorting. Tuning results of the new ATF2 Ultra-low lattice under realistic imperfections are also reported.

  15. New Toroid shielding design

    CERN Multimedia

    Hedberg V

    On the 15th of June 2001 the EB approved a new conceptual design for the toroid shield. In the old design, shown in the left part of the figure above, the moderator part of the shielding (JTV) was situated both in the warm and cold areas of the forward toroid. It consisted both of rings of polyethylene and hundreds of blocks of polyethylene (or an epoxy resin) inside the toroid vacuum vessel. In the new design, shown to the right in the figure above, only the rings remain inside the toroid. To compensate for the loss of moderator in the toroid, the copper plug (JTT) has been reduced in radius so that a layer of borated polyethylene can be placed around it (see figure below). The new design gives significant cost-savings and is easier to produce in the tight time schedule of the forward toroid. Since the amount of copper is reduced the weight that has to be carried by the toroid is also reduced. Outgassing into the toroid vacuum was a potential problem in the old design and this is now avoided. The main ...

  16. Toroid magnet test facility

    CERN Multimedia

    2002-01-01

    Because of its exceptional size, it was not feasible to assemble and test the Barrel Toroid - made of eight coils - as an integrated toroid on the surface, prior to its final installation underground in LHC interaction point 1. It was therefore decided to test these eight coils individually in a dedicated test facility.

  17. Samus Toroid Installation Fixture

    Energy Technology Data Exchange (ETDEWEB)

    Stredde, H.; /Fermilab

    1990-06-27

    The SAMUS (Small Angle Muon System) toroids have been designed and fabricated in the USSR and delivered to D0 ready for installation into the D0 detector. These toroids will be installed into the aperture of the EF's (End Toroids). The aperture in the EF's is 72-inch vertically and 66-inch horizontally. The Samus toroid is 70-inch vertically by 64-inch horizontally by 66-inch long and weighs approximately 38 tons. The Samus toroid has a 20-inch by 20-inch aperture in the center and it is through this aperture that the lift fixture must fit. The toroid must be 'threaded' through the EF aperture. Further, the Samus toroid coils are wound about the vertical portion of the aperture and thus limit the area where a lift fixture can make contact and not damage the coils. The fixture is designed to lift along a surface adjacent to the coils, but with clearance to the coil and with contact to the upper steel block of the toroid. The lift and installation will be done with the 50 ton crane at DO. The fixture was tested by lifting the Samus Toroid 2-inch off the floor and holding the weight for 10 minutes. Deflection was as predicted by the design calculations. Enclosed are sketches of the fixture and it relation to both Toroids (Samus and EF), along with hand calculations and an Finite Element Analysis. The PEA work was done by Kay Weber of the Accelerator Engineering Department.

  18. Beam halo study on ATF damping ring

    CERN Document Server

    Wang, Dou; Yokoya, Kaoru; Naito, Takashi; Gao, Jie

    2016-01-01

    Halo distribution is a key topic for background study. This paper has developed an analytical method to give an estimation of ATF beam halo distribution. The equilibrium particle distribution of the beam tail in the ATF damping ring is calculated analytically with different emittance and different vacuum degree. The analytical results agree the measurements very well. This is a general method which can be applied to any electron rings.

  19. Toroidal optical activity

    CERN Document Server

    Raybould, T A; Papasimakis, N; Kuprov, I; Youngs, I; Chen, W T; Tsai, D P; Zheludev, N I

    2015-01-01

    Optical activity is ubiquitous across natural and artificial media and is conventionally understood in terms of scattering from electric and magnetic moments. Here we demonstrate experimentally and confirm numerically a type of optical activity that cannot be attributed to electric and magnetic multipoles. We show that our observations can only be accounted for by the inclusion of the toroidal dipole moment, the first term of the recently established peculiar family of toroidal multipoles.

  20. Narrow zone heating by a new radiation focusing technique - Toroidal ellipsoid furnace. [for zone leveling and crystal growth in advanced multicomponent semiconductors

    Science.gov (United States)

    Davidson, M. C.; Holland, L. R.

    1978-01-01

    The paper describes the design of a toroidal ellipsoid furnace for narrow zone heating of materials in sealed transparent ampoules. The heater is a toroid flattened to an elliptical cross section like a partially inflated inner tube resting on a horizontal surface. The foci of the ellipsoid are two concentric rings. The outer focus is occupied by a heater wire, and the inner focus is arranged to fall on the surface of the cylindrical ingot within its transparent capsule. One advantage of the new furnace is that the wire heater closely approximates the ideal shape, lying along an extended line focus, as opposed to the elusive point source of the Costello furnace. Also, the ingot is heated uniformly around its circumference.

  1. ATF3 inhibits PPARγ-stimulated transactivation in adipocyte cells

    Energy Technology Data Exchange (ETDEWEB)

    Jang, Min-Kyung; Jung, Myeong Ho, E-mail: jung0603@pusan.ac.kr

    2015-01-02

    Highlights: • ATF3 inhibits PPARγ-stimulated transcriptional activation. • ATF3 interacts with PPARγ. • ATF3 suppresses p300-mediated transcriptional coactivation. • ATF3 decreases the binding of PPARγ and recruitment of p300 to PPRE. - Abstract: Previously, we reported that activating transcription factor 3 (ATF3) downregulates peroxisome proliferator activated receptor (PPARγ) gene expression and inhibits adipocyte differentiation in 3T3-L1 cells. Here, we investigated another role of ATF3 on the regulation of PPARγ activity. ATF3 inhibited PPARγ-stimulated transactivation of PPARγ responsive element (PPRE)-containing reporter or GAL4/PPARγ chimeric reporter. Thus, ATF3 effectively repressed rosiglitazone-stimulated expression of adipocyte fatty acid binding protein (aP2), PPARγ target gene, in 3T3-L1 cells. Coimmunoprecipitation and GST pulldown assay demonstrated that ATF3 interacted with PPARγ. Accordingly, ATF3 prevented PPARγ from binding to PPRE on the aP2 promoter. Furthermore, ATF3 suppressed p300-mediated transcriptional coactivation of PPRE-containing reporter. Chromatin immunoprecipitation assay showed that overexpression of ATF3 blocked both binding of PPARγ and recruitment of p300 to PPRE on aP2 promoter induced by rosiglitazone treatment in 3T3-L1 cells. Taken together, these results suggest that ATF3 interacts with PPARγ and represses PPARγ-mediated transactivation through suppression of p300-stimulated coactivation in 3T3-L1 cells, which may play a role in inhibition of adipocyte differentiation.

  2. ATF2 tests and CLIC IR study

    CERN Document Server

    Angal-Kalinin, D; Jones, J; Scarfe, A; Tygier, S

    2013-01-01

    This task covered three separate subtasks dealing with ILC and CLIC beam delivery system and Interaction region studies as well as testing the tuning procedures at ATF2 final focus test facility. The proposed local chromaticity correction final focus system for both ILC as well as CLIC is being tested experimentally for the first time at ATF2, various tuning procedures have been applied to study the applicability of various procedures to the ILC and CLIC to optimize the interaction region. The CLIC IR region was studied in detail, and the impact and mitigation of CLIC detector solenoid effects on the beam orbit, coupling and extraction have been considered. The work programme of this task concentrated on central region integration of the ILC following the design changes proposed during the technical design phase of the ILC, participation in ATF2 beam tuning studies and CLIC interaction region studies.

  3. Progress in Compact Toroid Experiments

    Energy Technology Data Exchange (ETDEWEB)

    Dolan, Thomas James

    2002-09-01

    The term "compact toroids" as used here means spherical tokamaks, spheromaks, and field reversed configurations, but not reversed field pinches. There are about 17 compact toroid experiments under construction or operating, with approximate parameters listed in Table 1.

  4. ATF3 represses PPARγ expression and inhibits adipocyte differentiation

    Energy Technology Data Exchange (ETDEWEB)

    Jang, Min-Kyung; Jung, Myeong Ho, E-mail: jung0603@pusan.ac.kr

    2014-11-07

    Highlights: • ATF3 decrease the expression of PPARγ and its target gene in 3T3-L1 adipocytes. • ATF3 represses the promoter activity of PPARγ2 gene. • ATF/CRE (−1537/−1530) is critical for ATF3-mediated downregulation of PPARγ. • ATF3 binds to the promoter region containing the ATF/CRE. • ER stress inhibits adipocyte differentiation through downregulation of PPARγ by ATF3. - Abstract: Activating transcription factor 3 (ATF3) is a stress-adaptive transcription factor that mediates cellular stress response signaling. We previously reported that ATF3 represses CCAAT/enhancer binding protein α (C/EBPα) expression and inhibits 3T3-L1 adipocyte differentiation. In this study, we explored potential role of ATF3 in negatively regulating peroxisome proliferator activated receptor-γ (PPARγ). ATF3 decreased the expression of PPARγ and its target gene in 3T3-L1 adipocytes. ATF3 also repressed the activity of −2.6 Kb promoter of mouse PPARγ2. Overexpression of PPARγ significantly prevented the ATF3-mediated inhibition of 3T3-L1 differentiation. Transfection studies with 5′ deleted-reporters showed that ATF3 repressed the activity of −2037 bp promoter, whereas it did not affect the activity of −1458 bp promoter, suggesting that ATF3 responsive element is located between the −2037 and −1458. An electrophoretic mobility shift assay and chromatin immunoprecipitation assay demonstrated that ATF3 binds to ATF/CRE site (5′-TGACGTTT-3′) between −1537 and −1530. Mutation of the ATF/CRE site abrogated ATF3-mediated transrepression of the PPARγ2 promoter. Treatment with thapsigargin, endoplasmic reticulum (ER) stress inducer, increased ATF3 expression, whereas it decreased PPARγ expression. ATF3 knockdown significantly blocked the thapsigargin-mediated downregulation of PPARγ expression. Furthermore, overexpression of PPARγ prevented inhibition of 3T3-L1 differentiation by thapsigargin. Collectively, these results suggest that ATF3-mediated

  5. Analysis list: ATF7IP [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ATF7IP Epidermis + hg19 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/target/ATF7IP....1.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/target/ATF7IP.5.tsv http://dbarchive.biosciencedbc....jp/kyushu-u/hg19/target/ATF7IP.10.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/colo/ATF7IP.Epidermis.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/colo/Epidermis.gml ...

  6. Analysis list: Atf7ip [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Atf7ip Pluripotent stem cell + mm9 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/target/Atf7ip....1.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/target/Atf7ip.5.tsv http://dbarchive.biosc...iencedbc.jp/kyushu-u/mm9/target/Atf7ip.10.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/colo/Atf7ip.Plurip...otent_stem_cell.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/colo/Pluripotent_stem_cell.gml ...

  7. On the dynamic toroidal multipoles

    CERN Document Server

    Fernandez-Corbaton, Ivan; Rockstuhl, Carsten

    2015-01-01

    Toroidal multipoles are attracting research attention, particularly in the field of metamaterials. They are often understood as a multipolar family in its own right. The dynamic toroidal multipoles emerge from the separation of one of the two transverse multipoles into two parts, referred to as electric and toroidal. Here, we establish that the dynamic toroidal multipolar components of an electric current distribution cannot be determined by measuring the radiation from the source or its coupling to external electromagnetic waves. We analytically show how the split into electric and toroidal parts causes the appearance of non-radiative components in each of the two parts, which cancel when summed back together. The toroidal multipoles do not have an independent meaning with respect to their interaction with the radiation field. Their formal meaning is clear, however. They are the higher order terms of an expansion of the multipolar coefficients of electric parity with respect to the electromagnetic size of th...

  8. A Superconducting Magnet Upgrade of the ATF2 Final Focus

    Energy Technology Data Exchange (ETDEWEB)

    Parker B.; Anerella M.; Escallier J.; He P.; Jain A.; Marone A.; Wanderer P.; Wu K.C.; Hauviller C.; Marin E.; Tomas R.; Zimmermann F.; Bolzon B.; Jeremie A.; Kimura N.; Kubo K.; Kume T.; Kuroda S.; Okugi T.; Tauchi T.; Terunuma N.; Tomaru T.; Tsuchiya K.; Urakawa J.; Yamamoto A.; Bambabe P.; Coe P.; Urner D.; Seryi A.; Spencer C.; White G.

    2010-05-23

    The ATF2 facility at KEK is a proving ground for linear collider technology with a well instrumented extracted beam line and Final Focus (FF). The primary ATF2 goal is to demonstrate the extreme beam demagnification and spot stability needed for a linear collider FF. But the ATF2 FF uses water cooled magnets and the ILC baseline has a superconducting (SC) FF. We plan to upgrade ATF2 and replace some of the warm FF magnets with SC FF magnets. The ATF2 SC magnets, like the ILC FF, will made via direct wind construction. ATF2 coil winding is in progress at BNL and warm magnetic measurements indicate we have achieved good field quality. Studies indicate that having ATF2 FF magnets with larger aperture and better field quality should allow reducing the ATF2 FF beta function for study of focusing regimes relevant to CLIC. The ATF2 magnet cryostat will have laser view ports for directly monitoring cold mass movement. We plan to make stability measurements at BNL and KEK to relate ATF2 FF magnet performance to that of a full length ILC QD0 R and D FF prototype under construction at BNL.

  9. A Superconducting Magnet Upgrade of the ATF2 Final Focus

    Energy Technology Data Exchange (ETDEWEB)

    Parker, Brett; /Brookhaven; Anerella, Michael; /Brookhaven; Escallier, John; /Brookhaven; He, Ping; /Brookhaven; Jain, Animesh; /Brookhaven; Marone, Andrew; /Brookhaven; Wanderer, Peter; /Brookhaven; Wu, Kuo-Chen; /Brookhaven; Bambade, Philip; /Orsay, LAL; Bolzon, Benoit; /Annecy, LAPP; Jeremie, Andrea; /Annecy, LAPP; Coe, Paul; /Oxford U.; Urner, David /Oxford U.; Hauviller, Claude; /CERN; Marin, Eduardo; /CERN; Tomas, Rogelio; /CERN; Zimmermann, Frank; /CERN; Kimura, Nobuhiro; /KEK, Tsukuba; Kubo, Kiyoshi; /KEK, Tsukuba; Kume, Tatsuya /KEK, Tsukuba; Kuroda, Shigeru; /KEK, Tsukuba /KEK, Tsukuba /KEK, Tsukuba /KEK, Tsukuba /KEK, Tsukuba /KEK, Tsukuba /KEK, Tsukuba /KEK, Tsukuba /SLAC /SLAC /SLAC

    2012-07-05

    The ATF2 facility at KEK is a proving ground for linear collider technology with a well instrumented extracted beam line and Final Focus (FF). The primary ATF2 goal is to demonstrate the extreme beam demagnification and spot stability needed for a linear collider FF. But the ATF2 FF uses water cooled magnets and the ILC baseline has a superconducting (SC) FF. We plan to upgrade ATF2 and replace some of the warm FF magnets with SC FF magnets. The ATF2 SC magnets, like the ILC FF, will made via direct wind construction. ATF2 coil winding is in progress at BNL and warm magnetic measurements indicate we have achieved good field quality. Studies indicate that having ATF2 FF magnets with larger aperture and better field quality should allow reducing the ATF2 FF beta function for study of focusing regimes relevant to CLIC. The ATF2 magnet cryostat will have laser view ports for directly monitoring cold mass movement. We plan to make stability measurements at BNL and KEK to relate ATF2 FF magnet performance to that of a full length ILC QD0 R&D FF prototype under construction at BNL.

  10. A superconducting magnet upgrade of the ATF2 final focus

    CERN Document Server

    Parker, B; Escallier, J; He, P; Jain, P; Marone, A; Wanderer, P; Wu, KC; Hauviller, C; Marin, E; Tomas, R; Zimmermann, F; Bolzon, B; Jeremie, A; Kimura, N; Kubo, K; Kume, T; Kuroda, S; Okugi, T; Tauchi, T; Terunuma, N; Tomaru, T; Tsuchiya, K; Urakawa, J; Yamamoto, A; Bambade, P; Coe, P; Urner, D; Seryi, A; Spencer, C; White, G

    2010-01-01

    The ATF2 facility at KEK is a proving ground for linear collider technology with a well instrumented extracted beam line and Final Focus (FF). The primary ATF2 goal is to demonstrate the extreme beam demagnification and spot stability needed for a linear collider FF [1]. But the ATF2 FF uses water cooled magnets and the ILC baseline has a superconducting (SC) FF [2]. We plan to upgrade ATF2 and replace some of the warm FF magnets with SC FF magnets. The ATF2 SC magnets, like the ILC FF, will made via direct wind construction [3]. ATF2 coil winding is in progress at BNL and warm magnetic measurements indicate we have achieved good field quality. Studies indicate that having ATF2 FF magnets with larger aperture and better field quality should allow reducing the ATF2 FF beta function for study of focusing regimes relevant to CLIC [4]. The ATF2 magnet cryostat will have laser view ports for directly monitoring cold mass movement. We plan to make stability measurements at BNL and KEK to relate ATF2 FF magnet perfo...

  11. Analysis list: ATF4 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ATF4 Blood,Others + hg19 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/target/ATF4.1.tsv http:...//dbarchive.biosciencedbc.jp/kyushu-u/hg19/target/ATF4.5.tsv http://dbarchive.biosciencedbc.jp/...kyushu-u/hg19/target/ATF4.10.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/colo/ATF4.Blood.tsv,http://...dbarchive.biosciencedbc.jp/kyushu-u/hg19/colo/ATF4.Others.tsv http://dbarchive.bi...osciencedbc.jp/kyushu-u/hg19/colo/Blood.gml,http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/colo/Others.gml ...

  12. ATF2 Ultra-Low IP Betas Proposal

    CERN Document Server

    Bambade, P; Bai, S; Braun, H; Delahaye, J P; Marin, E; Schulte, D; Tomás, R; Zimmermann, F; Gao, J; Wang, D; Zhu, XW; Honda, Y; Kuroda, S; Okugi, T; Tauchi, T; Terunuma, N; Urakawa, J; Seryi, A; White, G; Woodley, M; Angal-Kalinin, D; Jones, J; Scarfe, A

    2010-01-01

    The CLIC Final Focus System has considerably larger chromaticity than those of ILC and its scaled test machine ATF2. We propose to reduce the IP betas of ATF2 to reach a CLIC-like chromaticity. This would also allow to study the FFS tuning difficulty as function of the IP beam spot size. Both the ILC and CLIC projects will largely benefit from the ATF2 experience at these ultra-low IP betas.

  13. On the Toroidal Leibniz Algebras

    Institute of Scientific and Technical Information of China (English)

    Dong LIU; Lei LIN

    2008-01-01

    Toroidal Leibniz algebras are the universal central extensions of the iterated loop algebras gOC[t±11 ,...,t±v1] in the category of Leibniz algebras. In this paper, some properties and representations of toroidal Leibniz algebras are studied. Some general theories of central extensions of Leibniz algebras are also obtained.

  14. The Recent Results of the ATF

    CERN Document Server

    Urakawa, J; Ross, M

    2003-01-01

    This report describes the recent results of the beam commissioning of the ATF at KEK. Recent progress on the studies on production of low emittance beam, multi-bunch beam operation and development on beam instrumentation are discussed. So far, a horizontal emittance of 1.7 +- 0.3 nm was measured with wire-scanners in the extraction line and with the horizontal spatial coherence using an SR interferometer. In addition, a vertical emittance of 15 +- 7.5 pm was measured with a laser wire and the SR interferometer in the ring and 5 wire scanners.

  15. Fabrication Control Plan for ORNL RH-LOCA ATF Test Specimens to be Irradiated in the ATR

    Energy Technology Data Exchange (ETDEWEB)

    Field, Kevin G. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Howard, Richard [Idaho National Lab. (INL), Idaho Falls, ID (United States); Teague, Michael [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2014-06-01

    The purpose of this fabrication plan is (1) to summarize the design of a set of rodlets that will be fabricated and then irradiated in the Advanced Test Reactor (ATR) and (2) provide requirements for fabrication and acceptance criteria for inspections of the Light Water Reactor (LWR) – Accident Tolerant Fuels (ATF) rodlet components. The functional and operational (F&OR) requirements for the ATF program are identified in the ATF Test Plan. The scope of this document only covers fabrication and inspections of rodlet components detailed in drawings 604496 and 604497. It does not cover the assembly of these items to form a completed test irradiation assembly or the inspection of the final assembly, which will be included in a separate INL final test assembly specification/inspection document. The controls support the requirements that the test irradiations must be performed safely and that subsequent examinations must provide valid results.

  16. Mineral trioxide aggregate induces osteoblastogenesis via Atf6

    Directory of Open Access Journals (Sweden)

    Toyonobu Maeda

    2015-06-01

    Full Text Available Mineral trioxide aggregate (MTA has been recommended for various uses in endodontics. To understand the effects of MTA on alveolar bone, we examined whether MTA induces osteoblastic differentiation using MC3T3-E1 cells. MTA enhanced mineralization concomitant with alkaline phosphatase activity in a dose- and time-dependent manner. MTA increased production of collagens (Type I and Type III and matrix metalloproteinases (MMP-9 and MMP-13, suggesting that MTA affects bone matrix remodeling. MTA also induced Bglap (osteocalcin but not Bmp2 (bone morphogenetic protein-2 mRNA expression. We observed induction of Atf6 (activating transcription factor 6, an endoplasmic reticulum (ER stress response transcription factor mRNA expression and activation of Atf6 by MTA treatment. Forced expression of p50Atf6 (active form of Atf6 markedly enhanced Bglap mRNA expression. Chromatin immunoprecipitation assay was performed to investigate the increase in p50Atf6 binding to the Bglap promoter region by MTA treatment. Furthermore, knockdown of Atf6 gene expression by introduction of Tet-on Atf6 shRNA expression vector abrogated MTA-induced mineralization. These results suggest that MTA induces in vitro osteoblastogenesis through the Atf6–osteocalcin axis as ER stress signaling. Therefore, MTA in endodontic treatment may affect alveolar bone healing in the resorbed region caused by pulpal infection.

  17. Coupling Measurements in ATF2 Extraction Line

    Energy Technology Data Exchange (ETDEWEB)

    Rimbault, Cecile; /Orsay, LAL; Kuroda, Shigeru; /KEK, Tsukuba; Tauchi, Toshiaki; /KEK, Tsukuba; Terunuma, Nobuhiro; /KEK, Tsukuba; White, Glen; /SLAC; Woodley, Mark; /SLAC

    2012-06-29

    The purpose of ATF2 is to deliver a beam with stable very small spotsizes as required for future linear colliders such as ILC or CLIC. To achieve that, precise controls of aberrations such as dispersion and coupling are necessary. Theoretically, the complete reconstruction of the beam matrix is possible from the measurements of horizontal, vertical and tilted beam sizes, combining skew quadrupole scans at several wire-scanner positions. Such measurements were performed in the extraction line (EXT) of ATF2 in May 2009. We present analysis results attempting to resolve the 4 x 4 beam matrix. We aimed to reconstruct the full beam matrix using only skew quadrupole scans at different EXT wire-scanner locations, with measurements of horizontal, vertical and two tilted beam size projections. Checking the coherence of the {sigma}{sub 13} reconstruction from the {sigma}{sub 80{sup o}} and the {sigma}{sub 100{sup o}} measurements was essential to perform this analysis. We have shown that reconstruction of the coupling element can not be performed independantly of the 4 x 4 diagonal ones since it leads to unphysical results. A more accurate and automatisable method was find, leading to physical beam matrix reconstruction, compatible with the measurements. Another analysis should be performed based on a larger number of data sets to minimise statistical errors.

  18. Micron size laser-wire system at the ATF extraction line, recent results and ATF-II upgrade

    Energy Technology Data Exchange (ETDEWEB)

    Aryshev, A., E-mail: alar@post.kek.j [John Adams Institute at Royal Holloway, Egham, Surrey TW20 0EX (United Kingdom); Blair, G.A.; Boogert, S.T.; Boorman, G.; Bosco, A. [John Adams Institute at Royal Holloway, Egham, Surrey TW20 0EX (United Kingdom); Corner, L. [John Adams Institute at Oxford University, Nuclear and Astrophysics Laboratory, Keble Road, Oxford OX1 3RH (United Kingdom); Deacon, L. [John Adams Institute at Royal Holloway, Egham, Surrey TW20 0EX (United Kingdom); Delerue, N.; Foster, B.; Gannaway, F. [John Adams Institute at Oxford University, Nuclear and Astrophysics Laboratory, Keble Road, Oxford OX1 3RH (United Kingdom); Hayano, H. [KEK, 1-1 Oho, Tsukuba, Ibaraki 305-0801 (Japan); Howell, D. [John Adams Institute at Oxford University, Nuclear and Astrophysics Laboratory, Keble Road, Oxford OX1 3RH (United Kingdom); Karataev, P. [John Adams Institute at Royal Holloway, Egham, Surrey TW20 0EX (United Kingdom); Nevay, L.; Newman, M.; Senanayake, R. [John Adams Institute at Oxford University, Nuclear and Astrophysics Laboratory, Keble Road, Oxford OX1 3RH (United Kingdom); Terunuma, N.; Urakawa, J. [KEK, 1-1 Oho, Tsukuba, Ibaraki 305-0801 (Japan); Walczak, R. [John Adams Institute at Oxford University, Nuclear and Astrophysics Laboratory, Keble Road, Oxford OX1 3RH (United Kingdom)

    2010-11-01

    The KEK Accelerator test facility (ATF) extraction line laser-wire system has been upgraded last year allowing the measurement of micron scale transverse size electron beams. The last measurements using the upgraded system from recent operation at the ATF are presented, demonstrating raw measurements of order 3{mu}m RMS. The main component contributions to this measurement are also discussed.

  19. Micron size laser-wire system at the ATF extraction line, recent results and ATF-II upgrade

    Science.gov (United States)

    Aryshev, A.; Blair, G. A.; Boogert, S. T.; Boorman, G.; Bosco, A.; Corner, L.; Deacon, L.; Delerue, N.; Foster, B.; Gannaway, F.; Hayano, H.; Howell, D.; Karataev, P.; Nevay, L.; Newman, M.; Senanayake, R.; Terunuma, N.; Urakawa, J.; Walczak, R.

    2010-11-01

    The KEK Accelerator test facility (ATF) extraction line laser-wire system has been upgraded last year allowing the measurement of micron scale transverse size electron beams. The last measurements using the upgraded system from recent operation at the ATF are presented, demonstrating raw measurements of order 3 μm RMS. The main component contributions to this measurement are also discussed.

  20. Next generation toroidal devices

    Energy Technology Data Exchange (ETDEWEB)

    Yoshikawa, Shoichi [Princeton Plasma Physics Lab., Princeton Univ., NJ (United States)

    1998-10-01

    A general survey of the possible approach for the next generation toroidal devices was made. Either surprisingly or obviously (depending on one`s view), the technical constraints along with the scientific considerations lead to a fairly limited set of systems for the most favorable approach for the next generation devices. Specifically if the magnetic field strength of 5 T or above is to be created by superconducting coils, it imposes minimum in the aspect ratio for the tokamak which is slightly higher than contemplated now for ITER design. The similar technical constraints make the minimum linear size of a stellarator large. Scientifically, it is indicated that a tokamak of 1.5 times in the linear dimension should be able to produce economically, especially if a hybrid reactor is allowed. For the next stellarator, it is strongly suggested that some kind of helical axis is necessary both for the (almost) absolute confinement of high energy particles and high stability and equilibrium beta limits. The author still favors a heliac most. Although it may not have been clearly stated in the main text, the stability afforded by the shearless layer may be exploited fully in a stellarator. (author)

  1. Flavour formation in fungi: characterisation of KlAtf, the Kluyveromyces lactis orthologue of the Saccharomyces cerevisiae alcohol acetyltransferases Atf1 and Atf2.

    Science.gov (United States)

    Van Laere, Stijn D M; Saerens, Sofie M G; Verstrepen, Kevin J; Van Dijck, Patrick; Thevelein, Johan M; Delvaux, Freddy R

    2008-04-01

    Volatile aroma-active esters are responsible for the fruity character of fermented alcoholic beverages, such as beer and wine. In the brewers' yeast Saccharomyces cerevisiae, the major part of these esters is formed by two alcohol acetyltransferases, Atf1 and Atf2. In this paper, the existence of orthologues of these S. cerevisiae alcohol acetyltransferases in several ascomycetous fungi was investigated. Bioinformatic analysis of sequenced fungal genomes revealed the presence of multiple orthologues. The Saccharomyces sensu stricto yeasts all have two genes coding for orthologues. More distantly related fungi like Saccharomyces castelii, Candida glabrata, Kluyveromyces waltii and Kluyveromyces lactis have only one orthologue in their genome. The homology between the identified proteins and the S. cerevisiae alcohol acetyltransferases suggests a role for these orthologues in the aroma-active ester formation. To verify this, the K. lactis orthologue KlAtf was cloned and expressed in S. cerevisiae. Gas chromatographic analysis of small-scale fermentations with the transformant strains showed that, while S. cerevisiae ATF1 overexpression resulted in a substantial increase in acetate ester levels, S. cerevisiae ATF2 and K. lactis ATF overexpression only caused a moderate increase in acetate esters. This study is the first report of the presence of an ester synthesis gene in K. lactis.

  2. CAVITY BEAM POSITION MONITOR SYSTEM FOR ATF2

    CERN Document Server

    Boogert, S T; Cullinan, F; Joshi, N; Lyapin, A; Aryshev, A; Honda, Y; Naito, T; Terunuma, N; Urakara, J; Heo, A; Kim, E-S; Kim, Y I; McCormick, D; Frisch, J; Nelson, J; Smith, T; White, G R

    2011-01-01

    The Accelerator Test Facility 2 (ATF2) in KEK, Japan, is a prototype scaled demonstrator system for the final focus required for a future high energy lepton linear collider. The ATF2 beam-line is instrumented with a total of 41 high resolution C and S band resonant cavity beam position monitors (BPM) with associated mixer electronics and digitisers. In addition 4 high resolution BPMs have been recently installed at the interaction point, we briefly describe the first operational experience of these cavities in the ATF2 beam-line. The current status of the overall BPM system is also described, with a focus on operational techniques and performance.

  3. RF breakdown by toroidal helicons

    Indian Academy of Sciences (India)

    S K P Tripathi; D Bora; M Mishra

    2001-04-01

    Bounded whistlers are well-known for their efficient plasma production capabilities in thin cylindrical tubes. In this paper we shall present their radio frequency (RF) breakdown and discharge sustaining capabilities in toroidal systems. Pulsed RF power in the electronmagnetohydrodynamic (EMHD) frequency regime is fed to the neutral background medium. After the breakdown stage, discharge is sustained by toroidal bounded whistlers. In these pulsed experiments the behaviour of the time evolution of the discharge could be studied in four distinct phases of RF breakdown, steady state attainment, decay and afterglow. In the steady state average electron density of ≈ 1012 per cc and average electron temperature of ≈ 20 eV are obtained at 10-3 mbar of argon filling pressure. Experimental results on toroidal mode structure, background effects and time evolution of the electron distribution function will be presented and their implications in understanding the breakdown mechanism are discussed.

  4. Analytical solutions for Tokamak equilibria with reversed toroidal current

    Energy Technology Data Exchange (ETDEWEB)

    Martins, Caroline G. L.; Roberto, M.; Braga, F. L. [Departamento de Fisica, Instituto Tecnologico de Aeronautica, Sao Jose dos Campos, Sao Paulo 12228-900 (Brazil); Caldas, I. L. [Instituto de Fisica, Universidade de Sao Paulo, 05315-970 Sao Paulo, SP (Brazil)

    2011-08-15

    In tokamaks, an advanced plasma confinement regime has been investigated with a central hollow electric current with negative density which gives rise to non-nested magnetic surfaces. We present analytical solutions for the magnetohydrodynamic equilibria of this regime in terms of non-orthogonal toroidal polar coordinates. These solutions are obtained for large aspect ratio tokamaks and they are valid for any kind of reversed hollow current density profiles. The zero order solution of the poloidal magnetic flux function describes nested toroidal magnetic surfaces with a magnetic axis displaced due to the toroidal geometry. The first order correction introduces a poloidal field asymmetry and, consequently, magnetic islands arise around the zero order surface with null poloidal magnetic flux gradient. An analytic expression for the magnetic island width is deduced in terms of the equilibrium parameters. We give examples of the equilibrium plasma profiles and islands obtained for a class of current density profile.

  5. Prandtl number of toroidal plasmas

    Energy Technology Data Exchange (ETDEWEB)

    Itoh, Kimitaka (National Inst. for Fusion Science, Nagoya (Japan)); Itoh, Sanae; Fukuyama, Atsushi; Yagi, Masatoshi; Azumi, Masafumi

    1993-12-01

    Theory of the L-mode confinement in toroidal plasmas is developed. The Prandtl number, the ratio between the ion viscosity and the thermal conductivity is obtained for the anomalous transport process which is caused by the self-sustained turbulence in the toroidal plasma. It is found that the Prandtl number is of order unity both for the ballooning mode turbulence in tokamaks and for the interchange mode turbulence in helical system. The influence on the anomalous transport and fluctuation level is evaluated. Hartmann number and magnetic Prandtl number are also discussed. (author).

  6. Hybrid winding concept for toroids

    DEFF Research Database (Denmark)

    Schneider, Henrik; Andersen, Thomas; Knott, Arnold;

    2013-01-01

    This paper proposes a hybrid winding concept for toroids using the traces in a printed circuit board to make connection to bended copper foil cutouts. In a final product a number of strips with a certain thickness would be held by a former and the whole assembly could be placed by pick...... and placement machinery. This opens up the possibility for both an automated manufacturing process and an automated production process of toroidal magnetics such as power inductors, filtering inductors, air core inductors, transformers etc. Both the proposed hybrid and the common wire wound winding...

  7. ATF3 suppresses ESCC via downregulation of ID1

    Science.gov (United States)

    Li, Jian; Yang, Zishan; Chen, Zhiuguo; Bao, Yonghua; Zhang, Huijuan; Fang, Xinhui; Yang, Wancai

    2016-01-01

    Esophageal cancer is one of the most prevalent forms of cancer and has a particularly high mortality rate due to early metastasis; however, the underlying mechanisms of its formation and progression remain unclear. The present study performed immunohistochemical analysis and observed that the expression of activating transcription factor 3 (ATF3) was reduced in esophageal squamous cell carcinoma (ESCC) in comparison with non-tumor adjacent tissues. By contrast, inhibitor of DNA binding 1 (ID1) was overexpressed in ESCC tissues, demonstrating an inverse correlation with ATF3 (P<0.01). In ESCC EC109 and KYSE450 cells lines, transfection with an ATF3-overexpression plasmid resulted in the inhibition of cell proliferation, motility and migration, which was associated with the induction of E-cadherin expression and inhibition of cyclin D1 and Twist. Notably, ATF3 exerted an inverse regulatory interaction with ID1. The results of the present study provide additional evidence of the tumor suppressive features of ATF3 and demonstrate a novel mechanism of ATF3-mediated inhibition of cancer metastasis in esophageal cancer. PMID:27602100

  8. The complex and unique ATLAS Toroid family

    CERN Multimedia

    2002-01-01

    Big parts for the toroid magnets that will be used in the ATLAS experiment have been continuously arriving at CERN since March. These structures will create the largest superconducting toroid magnet ever.

  9. Micron Size Laser-Wire System at the ATF Extraction Line, Recent Results and ATF-II Upgrade

    CERN Document Server

    Blair, G A; Boorman, G; Bosco, A; Deacon, L; Karataev, P; Howell, D; Nevay, L J; Corner, L; Delerue, N; Foster, B; Gannaway, F; Newman, M; Senanayake, R; Walczak, R; Hayano, H; Aryshev, A; Terunuma, N; Urakawa, J

    2010-01-01

    The KEK Accelerator test facility (ATF) extraction line laser-wire system has been upgraded last year allowing the measurement of micron scale transverse size electron beams. The most recent measurements using the upgraded system are presented. The ATF-II extraction line design call for the major upgrade of the existing laser-wire system. We report on the hardware upgrades, including the major hardware upgrades to the laser transport, the laser beam diagnostics line, and the mechanical control systems.

  10. Hybrid winding concept for toroids

    DEFF Research Database (Denmark)

    Schneider, Henrik; Andersen, Thomas; Knott, Arnold;

    2013-01-01

    This paper proposes a hybrid winding concept for toroids using the traces in a printed circuit board to make connection to bended copper foil cutouts. In a final product a number of strips with a certain thickness would be held by a former and the whole assembly could be placed by pick and placem...

  11. Onsager relaxation of toroidal plasmas

    Energy Technology Data Exchange (ETDEWEB)

    Samain, A.; Nguyen, F.

    1997-01-01

    The slow relaxation of isolated toroidal plasmas towards their thermodynamical equilibrium is studied in an Onsager framework based on the entropy metric. The basic tool is a variational principle, equivalent to the kinetic equation, involving the profiles of density, temperature, electric potential, electric current. New minimization procedures are proposed to obtain entropy and entropy production rate functionals. (author). 36 refs.

  12. ATLAS End Cap toroid in upstanding position

    CERN Multimedia

    2005-01-01

    End Cap toroid The ATLAS End Cap toroid weights 240-ton and is 12-m diameter high. The parts of this vacuum vessel had to be integrated and tested so that End Cap Toroid has no leaks. After that it could be cooled down to 80 K.

  13. Extremely high Q-factor toroidal metamaterials

    CERN Document Server

    Basharin, Alexey A; Volsky, Nikita; Kafesaki, Maria; Economou, Eleftherios N; Ustinov, Alexey V

    2016-01-01

    We demonstrate that, owing to the unique topology of the toroidal dipolar mode, its electric/magnetic field can be spatially confined within subwavelength, externally accessible regions of the metamolecules, which makes the toroidal planar metamaterials a viable platform for high Q-factor resonators due to interfering toroidal and other dipolar modes in metamolecules.

  14. Intrinsic rotation of toroidally confined magnetohydrodynamics.

    Science.gov (United States)

    Morales, Jorge A; Bos, Wouter J T; Schneider, Kai; Montgomery, David C

    2012-10-26

    The spatiotemporal self-organization of viscoresistive magnetohydrodynamics in a toroidal geometry is studied. Curl-free toroidal magnetic and electric fields are imposed. It is observed in our simulations that a flow is generated, which evolves from dominantly poloidal to toroidal when the Lundquist numbers are increased. It is shown that this toroidal organization of the flow is consistent with the tendency of the velocity field to align with the magnetic field. Up-down asymmetry of the geometry causes the generation of a nonzero toroidal angular momentum.

  15. Design and Simulation of Toroidal Twister Model

    Institute of Scientific and Technical Information of China (English)

    TIAN Huifang; LIN Xizhen; ZENG Qinqin

    2006-01-01

    Toroidal composite vessel winded with fiber is a new kind of structural pressure vessels, which not only has high structure efficiency of compound materials pressure vessel, good security and so on, but also has special shape and the property of utilizing toroidal space, and the prospect of the application of toroidal composite vessel winded with fiber is extremely broad. By introducing parameters establishment of toroidal vessel and elaborating the principle of filament winding for toroidal vessel, the design model of filament winding machine for toroidal vessel has been introduced, and the design model has been dynamically simulated by the software of ADAMS, which will give more referrence for the design of real toroidal vessel twister.

  16. Design and high order optimization of the ATF2 lattices

    CERN Document Server

    Marin, E; Woodley, M; Kubo, K; Okugi, T; Tauchi, T; Urakawa, J; Tomas, R

    2013-01-01

    The next generation of future linear colliders (LC) demands nano-meter beam sizes at the interaction point (IP) in order to reach the required luminosity. The final focus system (FFS) of a LC is meant to deliver such small beam sizes. The Accelerator Test Facility (ATF) aims to test the feasibility of the new local chromaticity correction scheme which the future LCs are based on. To this end the ATF2 nominal and ultra-low beta* lattices are design to vertically focus the beam at the IP to 37nm and 23nm, respectively if error-free lattices are considered. However simulations show that the measured field errors of the ATF2 magnets preclude to reach the mentioned spot sizes. This paper describes the optimization of high order aberrations of the ATF2 lattices in order to minimize the detrimental effect of the measured multipole components for both ATF2 lattices. Specifically three solutions are studied, the replacement of the last focusing quadrupole (QF1FF), insertion of octupole magnets and optics modification....

  17. Classification of symmetric toroidal orbifolds

    Energy Technology Data Exchange (ETDEWEB)

    Fischer, Maximilian; Ratz, Michael; Torrado, Jesus [Technische Univ. Muenchen, Garching (Germany). Physik-Department; Vaudrevange, Patrick K.S. [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany)

    2012-09-15

    We provide a complete classification of six-dimensional symmetric toroidal orbifolds which yield N{>=}1 supersymmetry in 4D for the heterotic string. Our strategy is based on a classification of crystallographic space groups in six dimensions. We find in total 520 inequivalent toroidal orbifolds, 162 of them with Abelian point groups such as Z{sub 3}, Z{sub 4}, Z{sub 6}-I etc. and 358 with non-Abelian point groups such as S{sub 3}, D{sub 4}, A{sub 4} etc. We also briefly explore the properties of some orbifolds with Abelian point groups and N=1, i.e. specify the Hodge numbers and comment on the possible mechanisms (local or non-local) of gauge symmetry breaking.

  18. Transporting the first ATLAS toroid

    CERN Multimedia

    Maximilien Brice

    2004-01-01

    The first coil for the ATLAS toroid magnet is transported from its assembly hall at the CERN Meyrin site to the storage hall above the ATLAS cavern. This involves driving the massive transportation vehicle first through the Meyrin site and then across a main road only metres from the France-Swiss border. Eight magnets in total will be transported in this way before being lowered into the experimental cavern where they will be mounted in a huge ring surrounding the detector.

  19. Magnetic Properties of 3D Printed Toroids

    Science.gov (United States)

    Bollig, Lindsey; Otto, Austin; Hilpisch, Peter; Mowry, Greg; Nelson-Cheeseman, Brittany; Renewable Energy; Alternatives Lab (REAL) Team

    Transformers are ubiquitous in electronics today. Although toroidal geometries perform most efficiently, transformers are traditionally made with rectangular cross-sections due to the lower manufacturing costs. Additive manufacturing techniques (3D printing) can easily achieve toroidal geometries by building up a part through a series of 2D layers. To get strong magnetic properties in a 3D printed transformer, a composite filament is used containing Fe dispersed in a polymer matrix. How the resulting 3D printed toroid responds to a magnetic field depends on two structural factors of the printed 2D layers: fill factor (planar density) and fill pattern. In this work, we investigate how the fill factor and fill pattern affect the magnetic properties of 3D printed toroids. The magnetic properties of the printed toroids are measured by a custom circuit that produces a hysteresis loop for each toroid. Toroids with various fill factors and fill patterns are compared to determine how these two factors can affect the magnetic field the toroid can produce. These 3D printed toroids can be used for numerous applications in order to increase the efficiency of transformers by making it possible for manufacturers to make a toroidal geometry.

  20. Transforming growth factor-beta1 regulation of ATF-3 and identification of ATF-3 target genes in breast cancer cells.

    Science.gov (United States)

    Kwok, Sukyee; Rittling, Susan R; Partridge, Nicola C; Benson, Chellakkan S; Thiyagaraj, Mayuranathan; Srinivasan, Narasimhan; Selvamurugan, Nagarajan

    2009-10-01

    Transforming growth factor-beta1 (TGF-beta1) is a crucial molecule for stimulation of breast cancer invasion and formation of bone metastases. The molecular mechanisms of how TGF-beta1 mediates these effects have yet to be completely determined. We have found that activating transcription factor-3 (ATF-3) is strongly stimulated and its level is sustained by TGF-beta1 in highly invasive and metastatic human breast cancer (MDA-MB231) and in mouse mammary pad tumor cells (r3T). ATF-3 is also overexpressed in human primary breast cancer tissue. Overexpression of ATF-3 increased normal human mammary epithelial cell number and DNA synthesis suggesting a role for ATF-3 in cell proliferation. The functional role of ATF-3 in breast cancer progression was determined by the RNA interference technique. Knockdown of ATF-3 by ATF-3 shRNA in MDA-MB231 cells decreased expression of cell cycle gene, cyclin A1 in MDA-MB231 cells. ATF-3 shRNA also decreased expression of an invasive and metastatic gene, matrix metalloproteinase-13 (MMP-13; collagenase-3) in these cells. Chromatin immunoprecipitation experiments identified the direct physical interaction of ATF-3 protein on the human MMP-13 promoter. Thus, the dysregulation of ATF-3 by TGF-beta1 is likely to activate cyclin A1 and MMP-13 genes in breast cancer cells and that would be key to the subsequent cancer cell invasion and metastasis.

  1. Miniature anastigmatic spectrometer design with a concave toroidal mirror.

    Science.gov (United States)

    Dong, Jianing; Chen, He; Zhang, Yinchao; Chen, Siying; Guo, Pan

    2016-03-01

    An advanced optical design for a low-cost and astigmatism-corrected spectrometer with a high resolution is presented. The theory and method of astigmatism correction are determined with the use of a concave toroidal mirror. The performances of a modified spectrometer and a traditional spectrometer are compared, and the analysis is verified. Experimentally, the limiting resolution of our spectrometer is 0.1 nm full width at half-maximum, as measured for 579.1 nm.

  2. Beam Transport in Toroidal Magnetic Field

    CERN Document Server

    Joshi, N; Meusel, O; Ratzinger, U

    2016-01-01

    The concept of a storage ring with toroidal magnetic field was presented in the two previous EPAC conferences. Here we report the first results of experiments performed with beam transport in toroidal magnetic fields and details of the injection system. The beam transport experiments were carried out with 30 degree toroidal segments with an axial magnetic field of 0.6T. The multi turn injection system relies on a transverse injection coil together with an electric kicker system.

  3. Fast ion behavior during neutral beam injection in ATF

    Energy Technology Data Exchange (ETDEWEB)

    Wade, M.R.; Thomas, C.E.; Colchin, R.J.; Rome, J.A.; England, A.C.; Fowler, R.H. [Oak Ridge National Lab., TN (United States); Aceto, S.C. [Rensselaer Polytechnic Inst., Troy, NY (United States)

    1993-09-01

    In stellarators, single-particle confinement properties can be more complex than in their tokamak counterparts. Fast-ion behavior in tokamaks has been well characterized through an abundance of measurements on various devices and in general has been shown to be consistent with classical slowing-down theory, although anomalous ion behavior has been observed during intense beam injection in ISX-B, during fishbone instabilities in PDX, and in experiments on TFR. In contrast, fast ion behavior in stellarators is not as wel established experimentally with the primary experiments to date focusing o near-perpendicular or perpendicular neutral beam injection (NBI) on the Wendelstein 7-A stellarator (91 and Heliotron-E. This paper addresses fast-ion confinement properties in a large-aspect-ratio, moderate-shear stellarator, the Advanced Toroidal Facility, during tangential NBI. The primary data used in this study are the experimentally measured energy spectra of charge-exchange neutrals escaping from the plasma, using a two-dimensional scanning neutral particle analyzer. This diagnostic method is well established, having been used on several devices since the early 1970`s. Various aspects of fast-ion behavior are investigated by comparing these data with computed theoretical spectra based on energeticion distributions derived from the fastion Fokker-Planck equation. Ion orbits are studied by computer orbit following, by the computation of J* surfaces, and by Monte Carlo calculations.

  4. A role for ATF2 in regulating MITF and melanoma development.

    Directory of Open Access Journals (Sweden)

    Meera Shah

    2010-12-01

    Full Text Available The transcription factor ATF2 has been shown to attenuate melanoma susceptibility to apoptosis and to promote its ability to form tumors in xenograft models. To directly assess ATF2's role in melanoma development, we crossed a mouse melanoma model (Nras(Q61K::Ink4a⁻/⁻ with mice expressing a transcriptionally inactive form of ATF2 in melanocytes. In contrast to 7/21 of the Nras(Q61K::Ink4a⁻/⁻ mice, only 1/21 mice expressing mutant ATF2 in melanocytes developed melanoma. Gene expression profiling identified higher MITF expression in primary melanocytes expressing transcriptionally inactive ATF2. MITF downregulation by ATF2 was confirmed in the skin of Atf2⁻/⁻ mice, in primary human melanocytes, and in 50% of human melanoma cell lines. Inhibition of MITF transcription by MITF was shown to be mediated by ATF2-JunB-dependent suppression of SOX10 transcription. Remarkably, oncogenic BRAF (V600E-dependent focus formation of melanocytes on soft agar was inhibited by ATF2 knockdown and partially rescued upon shMITF co-expression. On melanoma tissue microarrays, a high nuclear ATF2 to MITF ratio in primary specimens was associated with metastatic disease and poor prognosis. Our findings establish the importance of transcriptionally active ATF2 in melanoma development through fine-tuning of MITF expression.

  5. p38beta2-mediated phosphorylation and sumoylation of ATF7 are mutually exclusive.

    Science.gov (United States)

    Camuzeaux, Barbara; Diring, Jessica; Hamard, Pierre-Jacques; Oulad-Abdelghani, Mustapha; Donzeau, Mariel; Vigneron, Marc; Kedinger, Claude; Chatton, Bruno

    2008-12-26

    The ubiquitous activating transcription factor (ATF) 7 binds as a homodimer to the cAMP response element/TPA response element motifs present in the promoters of its target genes. ATF7 is homologous to ATF2 and heterodimerizes with Jun or Fos proteins, modulating their DNA-binding specificities. We previously demonstrated that TAF12, a component of the TFIID general transcription factor, mediates ATF7 transcriptional activity through direct interactions between the two proteins. By contrast, ATF7, but not ATF2, is modified in vivo by sumoylation, which restricts its subcellular localization, thereby inhibiting its transcriptional activity. In the present study, we dissect the mechanism of this functional switch. We characterized the multisite phosphorylation of the ATF7 activation domain and identified one of the involved kinase, p38beta2 mitogen-activated protein kinase. In addition, we show that epidermal growth factor treatment results in a two-step modification mechanism of ATF7 activation domain. The Thr53 residue is phosphorylated first by a presently unknown kinase, allowing p38beta2 mitogen-activated protein kinase to modify the Thr51 residue, excluding the sumoylation of ATF7 protein. The resulting activation of transcription is related to an increased association of TAF12 with this phosphorylated form of ATF7. Our data therefore conclusively establish that sumoylation and phosphorylation of ATF7 are two antagonistic posttranslational modifications.

  6. Fast Dump of the ATLAS Toroids

    CERN Document Server

    Dudarev, A; Volpini, Giovanni; Dudarev, Alexey; Kate, Herman Ten

    2010-01-01

    The toroidal magnet system of the ATLAS Detector at CERN consists of a Barrel Toroid (BT) and two End Cap Toroids (ECT-A and ECT-C). Each toroid is built up from eight racetrack coils wound with an aluminum stabilized NbTi conductor and indirectly cooled by forced flow liquid helium. The three toroids operate in series at 20.5 kA with a total stored energy of 1.5 GJ. In order to verify the reliability and effectiveness of the quench protection system, series of fast dump tests have been performed first of the single toroids and finally of the entire toroidal magnet system. In this paper a model to simulate the fast dump of the ATLAS toroids in single mode operation and in full system configuration is presented. The model is validated through comparison with measured data extracted from the ramp-and-quench runs. The calculated energy dissipation in the various coils is in very good agreement (within 1-2\\%) with the enthalpy changes estimated from the temperature measurements of the different parts of the cold ...

  7. Electrostatics of a Family of Conducting Toroids

    Science.gov (United States)

    Lekner, John

    2009-01-01

    An exact solution is found for the electrostatic potential of a family of conducting charged toroids. The toroids are characterized by two lengths "a" and "b", with "a" greater than or equal to "2b". They are closed, with no hole in the "doughnut". The results are obtained by considering the potential of two equal charges, displaced from the…

  8. Toroidal effects on drift wave turbulence

    Energy Technology Data Exchange (ETDEWEB)

    LeBrun, M.J.; Tajima, T.; Gray, M.G.; Furnish, G.; Horton, W.

    1992-09-23

    The universal drift instability and other drift instabilities driven by density and temperature gradients in a toroidal system are investigated in both linear and nonlinear regimes via particle simulation. Runs in toroidal and cylindrical geometry show dramatic differences in plasma behavior, primarily due to the toroidicity-induced coupling of rational surfaces through the poloidal mode number m. In the toroidal system studied, the eigenmodes are seen to possess (i) an elongated, nearly global radial extent (ii) a higher growth rate than in the corresponding cylindrical system, (iii) an eigenfrequency nearly constant with radius, (iv) a global temperature relaxation and enhancement of thermal heat conduction. Most importantly, the measured Xi shows an increase with radius and an absolute value on the order of that observed in experiment. On the basis of our observations, we argue that the increase in Xi with radius observed in experiment is caused by the global nature of heat convection in the presence of toroidicity-induced mode coupling.

  9. Development of Toroidal Core Transformers

    Energy Technology Data Exchange (ETDEWEB)

    de Leon, Francisco [New York Univ. (NYU), Brooklyn, NY (United States). Dept. of Electrical and Computer Engineering

    2014-08-01

    The original objective of this project was to design, build and test a few prototypes of single-phase dry-type distribution transformers of 25 kVA, 2.4 kV primary to 120 V transformers using cores made of a continuous steel strip shaped like a doughnut (toroid). At different points during the development of the project, the scope was enhanced to include the more practical case of a 25 kVA transformer for a 13.8 kV primary system voltage. Later, the scope was further expanded to design and build a 50 kVA unit to transformer voltage from 7.62 kV to 2x120 V. This is a common transformer used by Con Edison of New York and they are willing to test it in the field. The project officially started in September 2009 and ended in May 2014. The progress was reported periodically to DOE in eighteen quarterly reports. A Continuation Application was submitted to DOE in June 2010. In May 2011 we have requested a non-cost extension of the project. In December 2011, the Statement of Project Objectives (SOPO) was updated to reflect the real conditions and situation of the project as of 2011. A second Continuation Application was made and funding was approved in 2013 by DOE and the end date was extended to May 2014. The technical challenges that were overcome in this project include: the development of the technology to pass the impulse tests, derive a model for the thermal performance, produce a sound mechanical design, and estimate the inrush current. However, the greatest challenge that we faced during the development of the project was the complications of procuring the necessary parts and materials to build the transformers. The actual manufacturing process is relatively fast, but getting all parts together is a very lengthy process. The main products of this project are two prototypes of toroidal distribution transformers of 7.62 kV (to be used in a 13.8 kV system) to 2x120 V secondary (standard utilization voltage); one is rated at 25 kVA and the other at 50 kVA. The 25 k

  10. Development of Toroidal Core Transformers

    Energy Technology Data Exchange (ETDEWEB)

    Leon, Francisco

    2014-05-31

    The original objective of this project was to design, build and test a few prototypes of singlephase dry-type distribution transformers of 25 kVA, 2.4 kV primary to 120 V transformers using cores made of a continuous steel strip shaped like a doughnut (toroid). At different points during the development of the project, the scope was enhanced to include the more practical case of a 25 kVA transformer for a 13.8 kV primary system voltage. Later, the scope was further expanded to design and build a 50 kVA unit to transformer voltage from 7.62 kV to 2x120 V. This is a common transformer used by Con Edison of New York and they are willing to test it in the field. The project officially started in September 2009 and ended in May 2014. The progress was reported periodically to DOE in eighteen quarterly reports. A Continuation Application was submitted to DOE in June 2010. In May 2011 we have requested a non-cost extension of the project. In December 2011, the Statement of Project Objectives (SOPO) was updated to reflect the real conditions and situation of the project as of 2011. A second Continuation Application was made and funding was approved in 2013 by DOE and the end date was extended to May 2014.The technical challenges that were overcome in this project include: the development of the technology to pass the impulse tests, derive a model for the thermal performance, produce a sound mechanical design, and estimate the inrush current. However, the greatest challenge that we faced during the development of the project was the complications of procuring the necessary parts and materials to build the transformers. The actual manufacturing process is relatively fast, but getting all parts together is a very lengthy process. The main products of this project are two prototypes of toroidal distribution transformers of 7.62 kV (to be used in a 13.8 kV system) to 2x120 V secondary (standard utilization voltage); one is rated at 25 kVA and the other at 50 kVA. The 25 k

  11. Identification of ATF2 as a transcriptional regulator of renin gene.

    Science.gov (United States)

    Desch, Michael; Hackmayer, Gerit; Todorov, Vladimir T

    2012-01-01

    The cAMP response element (enhCRE) in the distal enhancer regulatory region of renin gene is believed to play a major role in the control of renin transcription. enhCRE binds the CRE-binding protein (CREB), which is the main transcription factor target of cAMP signaling. Using the mouse renin-producing cell line As4.1 we found that activating transcription factor-2 (ATF2) also binds to enhCRE. N-terminal phosphorylation of ATF2, which controls its transactivation, is associated with downregulation of renin gene expression by the cytokine tumor necrosis factor-α (TNFα). The ubiquitin proteasome inhibitor MG132 also phosphorylates ATF2 and inhibits renin expression. Knockdown of ATF2 attenuated the suppression of renin gene expression by MG132, thus demonstrating that ATF2 mediates the inhibitory effect of MG132. In addition, MG132 increased the DNA-binding of ATF2 as well as the ratio of bound ATF2 to CREB. Using ATF2- and CREB-Gal4 fusion protein constructs coupled with luciferase reporter system we showed that ATF2 has a weaker transactivating capacity than CREB. These data suggest that ATF2 represses renin expression by drifting the transcriptional control of renin gene away from CREB. Accordingly, TNFα completely abrogated the cAMP-dependent stimulation of renin gene expression.

  12. Identification and characterization of a mitochondrial unfolded protein response transcription factor ATFS-1 in Litopenaeus vannamei.

    Science.gov (United States)

    Chen, Yong-Gui; Yue, Hai-Tao; Zhang, Ze-Zhi; Yuan, Feng-Hua; Bi, Hai-Tao; Yuan, Kai; Weng, Shao-Ping; He, Jian-Guo; Chen, Yi-Hong

    2016-07-01

    A mitochondrial specific stress response termed mitochondrial unfolded protein response (UPR(mt)) is activated in responding to disturbance of protein homeostasis in mitochondria. The activating transcription factor associated with stress-1 (designated as ATFS-1) is the key regulator of UPR(mt). To investigating the roles of ATFS-1 (LvATFS-1) in Litopenaeus vannamei mitochondrial stress remission and immunity, it's full length cDNA was cloned. The open reading frame of LvATFS-1 was 1, 557 bp in length, deducing to a 268 amino acids protein. LvATFS-1 was highly expressed in muscle, hemocytes and eyestalk. Subcellular location assays showed that N-terminal of LvATFS-1 contained a mitochondrial targeting sequence, which could directed the fused EGFP located to mitochondria. And the C-terminal of LvATFS-1, which had a nuclear localization signal, expressed in nucleus. The in vitro experiments verified that LvATFS-1 could reduced the level of intracellular reactive oxygen species (ROS). And results of real-time RT-PCR indicated that LvATFS-1 might scavenge excess ROS via ROS-eliminating genes regulation. Reporter gene assays showed that LvATFS-1 could upregulated the expression of the antimicrobial peptide genes in Drosophila Schneider 2 cells. Results of real-time RT-PCR showed that Vibrio alginolyticus or white spot syndrome virus (WSSV) infection induced the expression of LvATFS-1. And knocked-down LvATFS-1 by RNAi resulted in a higher cumulative mortality of L. vannamei upon V. alginolyticus or WSSV infection. These results suggested that LvATFS-1 not only rolled in mitochondrial specific stress responding, but also important for L. vannamei immunologic defence.

  13. Detect ground motion effects on the trajectory at ATF2

    CERN Document Server

    Rénier, Yves; Garcia, Rogelio

    2011-01-01

    The Accelerator Test Facility 2 (ATF2) commissioning group aims to demonstrate the feasibility of the Beam Delivery System (BDS) of the next linear colliders (ILC and CLIC) as well as to define and to test the tunning methods. As the design vertical beam sizes of the linear colliders are about few nanometers, the stability of the trajectory as well as the control of the aberrations are very critical. The magnet displacements induced by ground motion are large enough for CLIC to perturb the beam stability above requirements. It is planned to measure the displacement of the magnets and implement a feed-forward correcting the effects on the beam trajectory with correctors (dipoles). This article studies the possibility to detect ground motion effects on the beam trajectory at ATF2. Characteristics of the ground motion at ATF2 are presented, the effects of the magnet displacements on the beam trajectory are simulated and an algorithm predicting the induced trajectory fluctuations is evaluated. After the estimated...

  14. Study of Abnormal Vertical Emittance Growth in ATF Extraction Line

    Energy Technology Data Exchange (ETDEWEB)

    Alabau, M.; Faus-Golfe, A.; /Valencia U., IFIC; Alabau, M.; Bambade, P.; Brossard, J.; Le Meur, G.; Rimbault, C.; Touze, F.; /Orsay, LAL; Angal-Kalinin, D.; Jones, J.K.; /Daresbury; Appleby, R.; Scarfe, A.; /Manchester U.; Kuroda, S.; /KEK, Tsukuba; White, G.R.; Woodley, M.; /SLAC; Zimmermann, F.; /CERN

    2011-11-04

    Since several years, the vertical beam emittance measured in the Extraction Line (EXT) of the Accelerator Test Facility (ATF) at KEK, that will transport the electron beam from the ATF Damping Ring (DR) to the future ATF2 Final Focus beam line, is significantly larger than the emittance measured in the DR itself, and there are indications that it grows rapidly with increasing beam intensity. This longstanding problem has motivated studies of possible sources of this anomalous emittance growth. One possible contribution is non-linear magnetic fields in the extraction region experimented by the beam while passing off-axis through magnets of the DR during the extraction process. In this paper, simulations of the emittance growth are presented and compared to observations. These simulations include the effects of predicted non-linear field errors in the shared DR magnets and orbit displacements from the reference orbit in the extraction region. Results of recent measurements using closed orbit bumps to probe the relation between the extraction trajectory and the anomalous emittance growth are also presented.

  15. Compact toroid injection into C-2U

    Science.gov (United States)

    Roche, Thomas; Gota, H.; Garate, E.; Asai, T.; Matsumoto, T.; Sekiguchi, J.; Putvinski, S.; Allfrey, I.; Beall, M.; Cordero, M.; Granstedt, E.; Kinley, J.; Morehouse, M.; Sheftman, D.; Valentine, T.; Waggoner, W.; the TAE Team

    2015-11-01

    Sustainment of an advanced neutral beam-driven FRC for a period in excess of 5 ms is the primary goal of the C-2U machine at Tri Alpha Energy. In addition, a criteria for long-term global sustainment of any magnetically confined fusion reactor is particle refueling. To this end, a magnetized coaxial plasma-gun has been developed. Compact toroids (CT) are to be injected perpendicular to the axial magnetic field of C-2U. To simulate this environment, an experimental test-stand has been constructed. A transverse magnetic field of B ~ 1 kG is established (comparable to the C-2U axial field) and CTs are fired across it. As a minimal requirement, the CT must have energy density greater than that of the magnetic field it is to penetrate, i.e., 1/2 ρv2 >=B2 / 2μ0 . This criteria is easily met and indeed the CTs traverse the test-stand field. A preliminary experiment on C-2U shows the CT also capable of penetrating into FRC plasmas and refueling is observed resulting in a 20 - 30% increase in total particle number per single-pulsed CT injection. Results from test-stand and C-2U experiments will be presented.

  16. ATF4 is involved in the regulation of simulated microgravity induced integrated stress response

    Science.gov (United States)

    Li, Yingxian; Li, Qi; Wang, Xiaogang; Sun, Qiao; Wan, Yumin; Li, Yinghui; Bai, Yanqiang

    Objective: Many important metabolic and signaling pathways have been identified as being affected by microgravity, thereby altering cellular functions such as proliferation, differentiation, maturation and cell survival. It has been demonstrated that microgravity could induce all kinds of stress response such as endoplasmic reticulum stress and oxidative stress et al. ATF4 belongs to the ATF/CREB family of basic region leucine zipper transcription factors. ATF4 is induced by stress signals including anoxia/hypoxia, ER stress, amino acid deprivation and oxidative stress. ATF4 regulates the expression of genes involved in oxidative stress, amino acid synthesis, differentiation, metastasis and angiogenesis. The aim of this study was to examine the changes of ATF4 under microgravity, and to investigate the role of ATF4 in microgravity induced stress. MethodsMEF cells were cultured in clinostat to simulate microgravity. Reverse transcription polymerase chain reaction (RT-PCR) and western blotting were used to examine mRNA and protein levels of ATF4 expression under simulated microgravity in MEF cells. ROS levels were measured with the use of the fluorescent signal H2DCF-DA. GFP-XBP1 stably transfected cell lines was used to detect the extent of ER stress under microgravity by the intensity of GFP. Dual luciferase reporter assay was used to detect the activity of ATF4. Co-immunoprecipitation was performed to analyze protein interaction. Results: ATF4 protein levels in MEF cells increased under simulated microgravity. However, ATF4 mRNA levels were consistent. XBP1 splicing can be induced due to ER stress caused by simulated microgravity. At the same time, ROS levels were also increased. Increased ATF4 could promote the expression of CHOP, which is responsible for cell apoptosis. ATF4 also play an important role in cellular anti-oxidant stress. In ATF4 -/-MEF cells, the ROS levels after H2O2 treatment were obviously higher than that of wild type cells. HDAC4 was

  17. Pressure drop – flow characteristic investigations of ATF filter in automatic transmissions (AT of cars

    Directory of Open Access Journals (Sweden)

    Tadeusz Dziubak

    2014-12-01

    Full Text Available [b]Abstract[/b]. Potentials effects of pressure drop-flow characteristics of ATF filter on the hydraulic pumps are discussed. Draft device to investigations pressure drop-flow characteristics of ATF filter used in automatic transmissions constructed based on SAE J2312 standard is presented. Method of investigation pressure drop-flow characteristics of ATF filter used in automatic transmission is presented. The results of investigation pressure drop-flow characteristics Δp = f(QV of two types ATF filter (metal mesh and filter cloth in two technical conditions (at the beginning of the operation and after are presented and analyzed.[b]Keywords[/b]: AT — automatic transmissions, ATF — automatic transmission fluid, ATF filter, pressure drop-flow characteristic

  18. Tokamak with in situ magnetohydrodynamic generation of toroidal magnetic field

    Science.gov (United States)

    Schaffer, Michael J.

    1986-01-01

    A tokamak apparatus includes an electrically conductive metal pressure vessel for defining a chamber and confining liquid therein. A liner disposed within said chamber defines a toroidal space within the liner and confines gas therein. The metal vessel provides an electrically conductive path linking the toroidal space. Liquid metal is forced outwardly through the chamber outside of the toroidal space to generate electric current in the conductive path and thereby generate a toroidal magnetic field within the toroidal space. Toroidal plasma is developed within the toroidal space about the major axis thereof.

  19. Toroidal horizons in binary black hole mergers

    Science.gov (United States)

    Bohn, Andy; Kidder, Lawrence E.; Teukolsky, Saul A.

    2016-09-01

    We find the first binary black hole event horizon with a toroidal topology. It has been predicted that generically the event horizons of merging black holes should briefly have a toroidal topology. However, such a phase has never been seen in numerical simulations. Instead, in all previous simulations, the topology of the event horizon transitions directly from two spheres during the inspiral to a single sphere as the black holes merge. We find a coordinate transformation to a foliation of spacelike hypersurfaces that "cut a hole" through the event horizon surface, resulting in a toroidal event horizon, thus reconciling the numerical work with theoretical expectations. The demonstration requires extremely high numerical precision, which is made possible by a new event horizon code described in a companion paper. A torus could potentially provide a mechanism for violating topological censorship. However, these toroidal event horizons satisfy topological censorship by construction, because we can always trivially apply the inverse coordinate transformation to remove the topological feature.

  20. Toroidal Horizons in Binary Black Hole Mergers

    CERN Document Server

    Bohn, Andy; Teukolsky, Saul A

    2016-01-01

    We find the first binary black hole event horizon with a toroidal topology. It had been predicted that generically the event horizons of merging black holes should briefly have a toroidal topology, but such a phase has never been seen prior to this work. In all previous binary black hole simulations, in the coordinate slicing used to evolve the black holes, the topology of the event horizon transitions directly from two spheres during the inspiral to a single sphere as the black holes merge. We present a coordinate transformation to a foliation of spacelike hypersurfaces that "cut a hole" through the event horizon surface, resulting in a toroidal event horizon. A torus could potentially provide a mechanism for violating topological censorship. However, these toroidal event horizons satisfy topological censorship by construction, because we can always trivially apply the inverse coordinate transformation to remove the topological feature.

  1. A functional interaction between ATF7 and TAF12 that is modulated by TAF4.

    Science.gov (United States)

    Hamard, Pierre-Jacques; Dalbies-Tran, Rozenn; Hauss, Charlotte; Davidson, Irwin; Kedinger, Claude; Chatton, Bruno

    2005-05-12

    The ATF7 proteins, which are members of the cyclic AMP responsive binding protein (CREB)/activating transcription factor (ATF) family of transcription factors, display quite versatile properties: they can interact with the adenovirus E1a oncoprotein, mediating part of its transcriptional activity; they heterodimerize with the Jun, Fos or related transcription factors, likely modulating their DNA-binding specificity; they also recruit to the promoter a stress-induced protein kinase (JNK2). In the present study, we investigate the functional relationships of ATF7 with hsTAF12 (formerly hsTAF(II)20/15), which has originally been identified as a component of the general transcription factor TFIID. We show that overexpression of hsTAF12 potentiates ATF7-induced transcriptional activation through direct interaction with ATF7, suggesting that TAF12 is a functional partner of ATF7. In support of this conclusion, chromatin immunoprecipitation experiments confirm the interaction of ATF7 with TAF12 on an ATF7-responsive promoter, in the absence of any artificial overexpression of both proteins. We also show that the TAF12-dependent transcriptional activation is competitively inhibited by TAF4. Although both TAF12 isoforms (TAF12-1 and -2, formerly TAF(II)20 and TAF(II)15) interact with the ATF7 activation region through their histone-fold domain, only the largest, hsTAF12-1, mediates transcriptional activation through its N-terminal region.

  2. Improved antibody production in Chinese hamster ovary cells by ATF4 overexpression

    OpenAIRE

    Haredy, AM; Nishizawa, A.; Honda, K.; T. Ohya; Ohtake, H; Omasa, T

    2013-01-01

    To improve antibody production in Chinese hamster ovary (CHO) cells, the humanized antibody-producing CHO DP-12-SF cell line was transfected with the gene encoding activating transcription factor 4 (ATF4), a central factor in the unfolded protein response. Overexpression of ATF4 significantly enhanced the production of antibody in the CHO DP-12-SF cell line. The specific IgG production rate of in the ATF4-overexpressing CHO-ATF4-16 cells was approximately 2.4 times that of the parental host c...

  3. Celebrating the Barrel Toroid commissioning

    CERN Multimedia

    Peter Jenni

    ATLAS invited Funding Agency representatives and Laboratory Heads directly related to the funding and construction of the Barrel Toroid for a small ceremony on 13th December 2006 at Point 1, in order to mark the successful first full excitation of the BT (see last eNews). On that date, which was during the December CERN Council week, several of the Funding Agency Heads or their representatives could be present, representing CEA France, INFN Italy, BMBF Germany, Spain, Sweden, Switzerland, Russia, JINR Dubna and CERN. Speeches were delivered by the ATLAS spokesperson Peter Jenni thanking the Funding Partners in the name of the Collaboration, by Magnet Project Leader Herman ten Kate tracing the BT construction history, and by the CERN Director-General Robert Aymar congratulating all those who have contributed to the successful project. Herman ten Kate addressing the delegates. The text of the introductory address by Peter Jenni is reproduced here. "It is a great pleasure for me to welcome you all here...

  4. Regulatory interplay of Cockayne syndrome B ATPase and stress-response gene ATF3 following genotoxic stress

    DEFF Research Database (Denmark)

    Kristensen, Hans-Ulrik Svejstrup; Epanchintsev, Alexey; Rauschendorf, Marc-Alexander;

    2013-01-01

    RNA restarts on the arrival of RNA polymerase II and CSB and the subsequent release of ATF3 from its cAMP response element/ATF target site. In CSB-deficient cells ATF3 remains bound to the promoter, thereby preventing the arrival of polymerase II and the restart of transcription. Silencing of ATF3, as well......, immediate early genes such as activating transcription factor 3 (ATF3) are overexpressed. Although the ATF3 target genes, including dihydrofolate reductase (DHFR), were unable to recover RNA synthesis in CSB-deficient cells, transcription was restored rapidly in normal cells. There the synthesis of DHFR m...

  5. Toroidal eigenmodes in all-dielectric metamolecules

    Science.gov (United States)

    Tasolamprou, Anna C.; Tsilipakos, Odysseas; Kafesaki, Maria; Soukoulis, Costas M.; Economou, Eleftherios N.

    2016-11-01

    We present a thorough investigation of the electromagnetic resonant modes supported by systems of polaritonic rods placed at the vertices of canonical polygons. The study is conducted with rigorous finite-element eigenvalue simulations. To provide physical insight, the simulations are complemented with coupled mode theory (the analog of LCAO in molecular and solid state physics) and a lumped wire model capturing the coupling-caused reorganizations of the currents in each rod. The systems of rods, which form all-dielectric cyclic metamolecules, are found to support the unconventional toroidal dipole mode, consisting of the magnetic dipole mode in each rod. Besides the toroidal modes, the spectrally adjacent collective modes are identified. The evolution of all resonant frequencies with rod separation is examined. They are found to oscillate about the single-rod magnetic dipole resonance, a feature attributed to the leaky nature of the constituent modes. Importantly, we observe that ensembles of an odd number of rods produce larger frequency separation between the toroidal mode and its neighbor than the ones with an even number of rods. This increased spectral isolation, along with the low quality factor exhibited by the toroidal mode, favors the coupling of the commonly silent toroidal dipole to the outside world, rendering the proposed structure a prime candidate for controlling the observation of toroidal excitations and their interaction with the usually present electric dipole.

  6. Low-n shear Alfven spectra in axisymmetric toroidal plasmas

    Energy Technology Data Exchange (ETDEWEB)

    Cheng, C.Z.; Chance, M.S.

    1985-11-01

    In toroidal plasmas, the toroidal magnetic field is nonuniform over a magnetic surface and causes coupling of different poloidal harmonics. It is shown both analytically and numerically that the toroidicity not only breaks up the shear Alfven continuous spectrum, but also creates new, discrete, toroidicity-induced shear Alfven eigenmodes with frequencies inside the continuum gaps. Potential applications of the low-n toroidicity-induced shear Alfven eigenmodes on plasma heating and instabilities are addressed. 17 refs., 4 figs.

  7. High resolution upgrade of the ATF damping ring BPM system

    Energy Technology Data Exchange (ETDEWEB)

    Terunuma, N.; Urakawa, J.; /KEK, Tsukuba; Frisch, J.; May, J.; McCormick, D.; Nelson, J.; Seryi, A.; Smith, T.; Woodley, M.; /SLAC; Briegel, C.; Dysert, R.; /Fermilab

    2008-05-01

    A beam position monitor (BPM) upgrade at the KEK Accelerator Test Facility (ATF) damping ring has been accomplished in its first stage, carried out by a KEK/FNAL/SLAC collaboration under the umbrella of the global ILC R&D effort. The upgrade consists of a high resolution, high reproducibility read-out system, based on analog and digital downconversion techniques, digital signal processing, and also tests a new automatic gain error correction schema. The technical concept and realization, as well as preliminary results of beam studies are presented.

  8. Optical force on toroidal nanostructures: toroidal dipole versus renormalized electric dipole

    CERN Document Server

    Zhang, Xu-Lin; Lin, Zhifang; Sun, Hong-Bo; Chan, C T

    2015-01-01

    We study the optical forces acting on toroidal nanostructures. A great enhancement of optical force is unambiguously identified as originating from the toroidal dipole resonance based on the source-representation, where the distribution of the induced charges and currents is characterized by the three families of electric, magnetic, and toroidal multipoles. On the other hand, the resonant optical force can also be completely attributed to an electric dipole resonance in the alternative field-representation, where the electromagnetic fields in the source-free region are expressed by two sets of electric and magnetic multipole fields based on symmetry. The confusion is resolved by conceptually introducing the irreducible electric dipole, toroidal dipole, and renormalized electric dipole. We demonstrate that the optical force is a powerful tool to identify toroidal response even when its scattering intensity is dwarfed by the conventional electric and magnetic multipoles.

  9. ATF2, a paradigm of the multifaceted regulation of transcription factors in biology and disease.

    Science.gov (United States)

    Watson, Gregory; Ronai, Ze'ev; Lau, Eric

    2017-02-15

    Stringent transcriptional regulation is crucial for normal cellular biology and organismal development. Perturbations in the proper regulation of transcription factors can result in numerous pathologies, including cancer. Thus, understanding how transcription factors are regulated and how they are dysregulated in disease states is key to the therapeutic targeting of these factors and/or the pathways that they regulate. Activating transcription factor 2 (ATF2) has been studied in a number of developmental and pathological conditions. Recent findings have shed light on the transcriptional, post-transcriptional, and post-translational regulatory mechanisms that influence ATF2 function, and thus, the transcriptional programs coordinated by ATF2. Given our current knowledge of its multiple levels of regulation and function, ATF2 represents a paradigm for the mechanistic complexity that can regulate transcription factor function. Thus, increasing our understanding of the regulation and function of ATF2 will provide insights into fundamental regulatory mechanisms that influence how cells integrate extracellular and intracellular signals into a genomic response through transcription factors. Characterization of ATF2 dysfunction in the context of pathological conditions, particularly in cancer biology and response to therapy, will be important in understanding how pathways controlled by ATF2 or other transcription factors might be therapeutically exploited. In this review, we provide an overview of the currently known upstream regulators and downstream targets of ATF2.

  10. Improved antibody production in Chinese hamster ovary cells by ATF4 overexpression.

    Science.gov (United States)

    Haredy, Ahmad M; Nishizawa, Akitoshi; Honda, Kohsuke; Ohya, Tomoshi; Ohtake, Hisao; Omasa, Takeshi

    2013-12-01

    To improve antibody production in Chinese hamster ovary (CHO) cells, the humanized antibody-producing CHO DP-12-SF cell line was transfected with the gene encoding activating transcription factor 4 (ATF4), a central factor in the unfolded protein response. Overexpression of ATF4 significantly enhanced the production of antibody in the CHO DP-12-SF cell line. The specific IgG production rate of in the ATF4-overexpressing CHO-ATF4-16 cells was approximately 2.4 times that of the parental host cell line. Clone CHO-ATF4-16 did not show any change in growth rate compared with the parental cells or mock-transfected CHO-DP12-SF cells. The expression levels of mRNAs encoding both the antibody heavy and light chains in the CHO-ATF4-16 clone were analyzed. This analysis showed that ATF4 overexpression improved the total production and specific production rate of antibody without affecting the mRNA transcription level. These results indicate that ATF4 overexpression is a promising method for improving recombinant IgG production in CHO cells.

  11. The atf2 gene is involved in triacylglycerol biosynthesis and accumulation in the oleaginous Rhodococcus opacus PD630.

    Science.gov (United States)

    Hernández, Martín A; Arabolaza, Ana; Rodríguez, Eduardo; Gramajo, Hugo; Alvarez, Héctor M

    2013-03-01

    Rhodococcus opacus PD630 is an oleaginous bacterium able to accumulate large amounts of triacylglycerols (TAG) in different carbon sources. The last reaction for TAG biosynthesis is catalyzed by the bifunctional wax ester synthase/acyl-CoA:diacylglycerol acyltransferase (WS/DGAT) enzymes encoded by atf genes. R. opacus PD630 possesses at least 17 putative atf homologous genes in its genome, but only atf1 and atf2 exhibited a significant DGAT activity when expressed in E. coli, as revealed in a previous study. The contribution of atf1 gene to TAG accumulation by strain PD630 has been demonstrated previously, although additional Atfs may also contribute to lipid accumulation, since the atf1-disrupted mutant is still able to produce significant amounts of TAG (Alvarez et al., Microbiology 154:2327-2335, 2008). In this study, we investigated the in vivo role of atf2 gene in TAG accumulation by R. opacus PD630 by using different genetic strategies. The atf2-disrupted mutant exhibited a decrease in TAG accumulation (up to 25-30 %, w/w) and an approximately tenfold increase in glycogen formation in comparison with the wild-type strain. Surprisingly, in contrast to single mutants, a double mutant generated by the disruption of atf1 and atf2 genes only showed a very low effect in TAG and in glycogen accumulation under lipid storage conditions. Overexpression of atf1 and atf2 genes in strain PD630 promoted an increase of approximately 10 % (w/w) in TAG accumulation, while heterologous expression of atf2 gene in Mycobacterium smegmatis caused an increase in TAG accumulation during cultivation in nitrogen-rich media. This study demonstrated that, in addition to atf1 gene, atf2 is actively involved in TAG accumulation by the oleaginous R. opacus PD630.

  12. 75 FR 47254 - Elimination of Firearms Transaction Record, ATF Form 4473 (Low Volume) (2008R-21P)

    Science.gov (United States)

    2010-08-05

    ... Transaction Record, ATF Form 4473 (Low Volume) (2008R-21P) AGENCY: Bureau of Alcohol, Tobacco, Firearms, and... (ATF) by eliminating the Firearms Transaction Record, ATF Form 4473 (Low Volume (LV)), Parts I and II...) Part I, Firearms Transaction Record Part I--Low Volume--Over-The-Counter, or Form 4473 (LV) Part...

  13. Hall MHD Equilibrium of Accelerated Compact Toroids

    Science.gov (United States)

    Howard, S. J.; Hwang, D. Q.; Horton, R. D.; Evans, R. W.; Brockington, S. J.

    2007-11-01

    We examine the structure and dynamics of the compact toroid's magnetic field. The compact toroid is dramatically accelerated by a large rail-gun Lorentz force density equal to j xB. We use magnetic data from the Compact Toroid Injection Experiment to answer the question of exactly where in the system j xB has nonzero values, and to what extent we can apply the standard model of force-free equilibrium. In particular we present a method of analysis of the magnetic field probe signals that allows direct comparison to the predictions of the Woltjer-Taylor force-free model and Turner's generalization of magnetic relaxation in the presence of a non-zero Hall term and fluid vorticity.

  14. Ferroic nature of magnetic toroidal order.

    Science.gov (United States)

    Zimmermann, Anne S; Meier, Dennis; Fiebig, Manfred

    2014-09-05

    Electric dipoles and ferroelectricity violate spatial inversion symmetry, and magnetic dipoles and ferromagnetism break time-inversion symmetry. Breaking both symmetries favours magnetoelectric charge-spin coupling effects of enormous interest, such as multiferroics, skyrmions, polar superconductors, topological insulators or dynamic phenomena such as electromagnons. Extending the rationale, a novel type of ferroic order violating space- and time-inversion symmetry with a single order parameter should exist. This existence is fundamental and the inherent magnetoelectric coupling is technologically interesting. A uniform alignment of magnetic vortices, called ferrotoroidicity, was proposed to represent this state. Here we demonstrate that the magnetic vortex pattern identified in LiCoPO4 exhibits the indispensable hallmark of such a ferroic state, namely hysteretic poling of ferrotoroidic domains in the conjugate toroidal field, along with a distinction of toroidal from non-toroidal poling effects. This consolidates ferrotoroidicity as fourth form of ferroic order.

  15. Packing of charged chains on toroidal geometries

    Science.gov (United States)

    Yao, Zhenwei; de la Cruz, Monica Olvera

    2013-01-01

    We study a strongly adsorbed flexible polyelectrolyte chain on tori. In this generalized Thomson problem, the patterns of the adsorbed chain are analyzed in the space of the toroidal coordinates and in terms of the orientation of each chain segment. Various patterns are found, including double spirals, disclination-like structures, Janus tori, and uniform wrappings, arising from the long-range electrostatic interaction and the toroidal geometry. Their broken mirror symmetry is quantitatively characterized by introducing an order parameter, an integral of the torsion. The uniform packing, which breaks the mirror symmetry the least, has the lowest value of the order parameter. In addition, it is found that the electrostatic energy of confined chains on tori conforms to a power law regardless of the screening effect in some typical cases studied. Furthermore, we study random walks on tori that generate chain configurations in the large screening limit or at large thermal fluctuation; some features associated with the toroidal geometry are discussed.

  16. Toroidal Precession as a Geometric Phase

    Energy Technology Data Exchange (ETDEWEB)

    J.W. Burby and H. Qin

    2012-09-26

    Toroidal precession is commonly understood as the orbit-averaged toroidal drift of guiding centers in axisymmetric and quasisymmetric configurations. We give a new, more natural description of precession as a geometric phase effect. In particular, we show that the precession angle arises as the holonomy of a guiding center's poloidal trajectory relative to a principal connection. The fact that this description is physically appropriate is borne out with new, manifestly coordinate-independent expressions for the precession angle that apply to all types of orbits in tokamaks and quasisymmetric stellarators alike. We then describe how these expressions may be fruitfully employed in numerical calculations of precession.

  17. Some properties of toroidal isodynamic magnetostatic equilibria

    Energy Technology Data Exchange (ETDEWEB)

    Aly, J.-J. [AIM, Unite Mixte de Recherche CEA, CNRS, Universite Paris VII, UMR no 7158, Centre d' Etudes de Saclay, F-91191 Gif sur Yvette Cedex (France)

    2011-09-15

    We establish some general properties of a 3D isodynamic magnetostatic equilibrium admitting a family of nested toroidal flux surfaces. In particular, we use the virial theorem to prove a simple relation between the total pressure (magnetic + thermal) and the magnetic pressure on each flux surface, and we derive some useful consequences of the latter. We also show the constancy on each rational surface of two integrals along magnetic lines. As a simple application of our results, we show the nonexistence of an equilibrium with vanishing toroidal current, and of an equilibrium with closed lines.

  18. Quench modeling of the ATLAS superconducting toroids

    CERN Document Server

    Gavrilin, A V; ten Kate, H H J

    2001-01-01

    Details of the normal zone propagation and the temperature distribution in the coils of ATLAS toroids under quench are presented. A tailor-made mathematical model and corresponding computer code enable obtainment of computational results for the propagation process over the coils in transverse (turn-to-turn) and longitudinal directions. The slow electromagnetic diffusion into the pure aluminum stabilizer of the toroid's conductor, as well as the essentially transient heat transfer through inter-turn insulation, is appropriately included in the model. The effect of nonuniform distribution of the magnetic field and the thermal links to the coil casing on the temperature gradients within the coils is analyzed in full. (5 refs).

  19. Observation of Central Toroidal Rotation Induced by ICRF on EAST

    Science.gov (United States)

    Pan, Xiayun; Wang, Fudi; Zhang, Xinjun; Lyu, Bo; Chen, Jun; Li, Yingying; Fu, Jia; Shi, Yuejiang; Yu, Yi; Ye, Minyou; Wan, Baonian

    2016-02-01

    Core plasma rotation of both L-mode and H-mode discharges with ion cyclotron range of frequency (ICRF) minority heating (MH) scheme was measured with a tangential X-ray imaging crystal spectrometer on EAST (Experimental Advanced Superconducting Tokamak). Co-current central impurity toroidal rotation change was observed in ICRF-heated L- and H-mode plasmas. Rotation increment as high as 30 km/s was generated at ∼1.7 MW ICRF power. Scaling results showed similar trend as the Rice scaling but with significant scattering, especially in L-mode plasmas. We varied the plasma current, toroidal field and magnetic configuration individually to study their effect on L-mode plasma rotation, while keeping the other major plasma parameters and heating unchanged during the scanning. It was found that larger plasma current could induce plasma rotation more efficiently. A scan of the toroidal magnetic field indicated that the largest rotation was obtained for on-axis ICRF heating. A comparison between lower-single-null (LSN) and double-null (DN) configurations showed that LSN discharges rendered a larger rotation change for the same power input and plasma parameters. supported by the National Magnetic Confinement Fusion Science Program of China (Nos. 2013GB112004 and 2015GB103002), National Natural Science Foundation of China (Nos. 11175208, 11305212, 11375235, 11405212 and 11261140328), the Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology (2014FXCX003) and Brain Korea 21 Program for Leading Universities & Students (BK21 PLUS)

  20. The transcription factor ATF3 acts as an oncogene in mouse mammary tumorigenesis

    Directory of Open Access Journals (Sweden)

    Thames Howard D

    2008-09-01

    Full Text Available Abstract Background Overexpression of the bZip transcription factor, ATF3, in basal epithelial cells of transgenic mice under the control of the bovine cytokeratin-5 (CK5 promoter has previously been shown to induce epidermal hyperplasia, hair follicle anomalies and neoplastic lesions of the oral mucosa including squamous cell carcinomas. CK5 is known to be expressed in myoepithelial cells of the mammary gland, suggesting the possibility that transgenic BK5.ATF3 mice may exhibit mammary gland phenotypes. Methods Mammary glands from nulliparous mice in our BK5.ATF3 colony, both non-transgenic and transgenic, were examined for anomalies by histopathology and immunohistochemistry. Nulliparous and biparous female mice were observed for possible mammary tumor development, and suspicious masses were analyzed by histopathology and immunohistochemistry. Human breast tumor samples, as well as normal breast tissue, were similarly analyzed for ATF3 expression. Results Transgenic BK5.ATF3 mice expressed nuclear ATF3 in the basal layer of the mammary ductal epithelium, and often developed squamous metaplastic lesions in one or more mammary glands by 25 weeks of age. No progression to malignancy was seen in nulliparous BK5.ATF3 or non-transgenic mice held for 16 months. However, biparous BK5.ATF3 mice developed mammary carcinomas with squamous metaplasia between 6 months and one year of age, reaching an incidence of 67%. Cytokeratin expression in the tumors was profoundly disturbed, including expression of CK5 and CK8 (characteristic of basal and luminal cells, respectively throughout the epithelial component of the tumors, CK6 (potentially a stem cell marker, CK10 (a marker of interfollicular epidermal differentiation, and mIRSa2 and mIRSa3.1 (markers of the inner root sheath of hair follicles. Immunohistochemical studies indicated that a subset of human breast tumors exhibit high levels of nuclear ATF3 expression. Conclusion Overexpression of ATF3 in CK5

  1. Loss of ATF2 function leads to cranial motoneuron degeneration during embryonic mouse development.

    Directory of Open Access Journals (Sweden)

    Julien Ackermann

    Full Text Available The AP-1 family transcription factor ATF2 is essential for development and tissue maintenance in mammals. In particular, ATF2 is highly expressed and activated in the brain and previous studies using mouse knockouts have confirmed its requirement in the cerebellum as well as in vestibular sense organs. Here we present the analysis of the requirement for ATF2 in CNS development in mouse embryos, specifically in the brainstem. We discovered that neuron-specific inactivation of ATF2 leads to significant loss of motoneurons of the hypoglossal, abducens and facial nuclei. While the generation of ATF2 mutant motoneurons appears normal during early development, they undergo caspase-dependent and independent cell death during later embryonic and foetal stages. The loss of these motoneurons correlates with increased levels of stress activated MAP kinases, JNK and p38, as well as aberrant accumulation of phosphorylated neurofilament proteins, NF-H and NF-M, known substrates for these kinases. This, together with other neuropathological phenotypes, including aberrant vacuolisation and lipid accumulation, indicates that deficiency in ATF2 leads to neurodegeneration of subsets of somatic and visceral motoneurons of the brainstem. It also confirms that ATF2 has a critical role in limiting the activities of stress kinases JNK and p38 which are potent inducers of cell death in the CNS.

  2. Tearing Mode Stability with Sheared Toroidal Flows

    Science.gov (United States)

    White, Ryan; Coppi, Bruno

    2016-10-01

    Toroidal plasma flow induced by neutral beam heating has been found to increase the stability of tearing modes in tokamak plasmas. The need to extrapolate current (experimentally-based) knowledge of tearing mode onset to future machines, requiresa better understanding of the essential physics. We consider the physics of flow near the rational surfaces. For realistic flow profiles, the velocity shear near the rational surface can be treated as a perturbation, and is found to amplify the dominant stabilizing effect of magnetic curvature. This effect can be seen using a cylindrical model if large-aspect-ratio corrections to the magnetic curvature are incorporated. On the other hand, the physical effects of toroidal rotation are completely absent in a cylinder, and require a fully-toroidal calculation to study. The toroidal rotation near the rational surface is found to couple to a geometrical parameter which vanishes for up-down symmetric profiles. Physically, the dominant effects of rotation arise from a Coriolis force, leading to flow directional dependence. This work is supported by the US DOE.

  3. Toroidal surfaces compared with spherocylindrical surfaces

    Science.gov (United States)

    Malacara-Doblado, Daniel; Malacara-Hernandez, Daniel; Garcia-Marquez, Jorge L.

    1995-08-01

    Toroidal and sphero-cylindrical optical surfaces are two different kinds of surfaces (Menchaca and Malacara, 1986), but they are almost identical in the vicinity of the optical axis. The separation between these two surfaces increases when the distance to the optical axis increases. In this work the separation between these two surfaces outside of the central region is analytically studied.

  4. Reduced Magnetohydrodynamic Equations in Toroidal Geometry

    Institute of Scientific and Technical Information of China (English)

    REN Shen-Ming; YU Guo-Yang

    2001-01-01

    By applying a new assumption of density, I.e. R2 p = const, the continuity equation is satisfied to the order ofe2`+with e being the inverse aspect ratio. In the case of large aspect ratio, a set of reduced magnetohydrodynamicequations in toroidal geometry are obtained. The new assumption about the density is supported by experimentalobservation to some extent.

  5. ATLAS Barrel Toroid magnet reached nominal field

    CERN Multimedia

    2006-01-01

     On 9 November the barrel toroid magnet reached its nominal field of 4 teslas, with an electrical current of 21 000 amperes (21 kA) passing through the eight superconducting coils as shown on this graph

  6. ATLAS: Full power for the toroid magnet

    CERN Multimedia

    2006-01-01

    The 9th of November was a memorable day for ATLAS. Just before midnight, the gigantic Barrel toroid magnet reached its nominal field of 4 teslas in the coil windings, with an electrical current of 21000 amperes (21 kA) passing through the eight superconducting coils (as seen on the graph). This achievement was obtained after several weeks of commissioning. The ATLAS Barrel Toroid was first cooled down for about six weeks in July-August to -269°C (4.8 K) and then powered up step-by-step in successive test sessions to 21 kA. This is 0.5 kA above the current required to produce the nominal magnetic field. Afterwards, the current was safely switched off and the stored magnetic energy of 1.1 gigajoules was dissipated in the cold mass, raising its temperature to a safe -218°C (55 K). 'We can now say that the ATLAS Barrel Toroid is ready for physics,' said Herman ten Kate, project leader for the ATLAS magnet system. The ATLAS barrel toroid magnet is the result of a close collaboration between the magnet la...

  7. Celebration for the ATLAS Barrel Toroid magnet

    CERN Multimedia

    2007-01-01

    Representatives from Funding Agencies and Barrel Toroid Magnet Laboratories during the ceremony. From left to right: Jean Zinn-Justin (Head of DAPNIA/CEA/Saclay), CERN Director-General Robert Aymar, and Roberto Petronzio (President INFN).Allan Clark (DPNC University Geneva) and Enrique Fernandez (IFAE Barcelona) were among the guests visiting the ATLAS cavern. The barrel toroid is visible in the background. A celebration took place at Point 1 on 13 December to toast the recent powering-up of the ATLAS barrel toroid magnet to full field (Bulletin No. 47-48/06). About 70 guests were invited to attend, mainly composed of representatives from funding partners and key members of the laboratory management teams of the barrel toroid magnet, representing CEA France, INFN Italy, BMBF Germany, Spain, Sweden, Switzerland, Russia, JINR Dubna and CERN. An introductory speech by ATLAS spokesperson Peter Jenni the scene for evening. This was followed by the ATLAS magnet system project leader Herman Ten Kate's account of the...

  8. Toroidal Automorphic Forms for Function Fields

    NARCIS (Netherlands)

    Lorscheid, O.

    2008-01-01

    The definition of a toroidal automorphic form is due to Don Zagier, who showed in a paper in 1979 that the vanishing of certain integrals of Eisenstein series over tori in GL(2) is related to the vanishing of the Riemann zeta function at the weight of the Eisenstein series; and thus a relation betwe

  9. Trapped ion mode in toroidally rotating plasmas

    Energy Technology Data Exchange (ETDEWEB)

    Artun, M.; Tang, W.M.; Rewoldt, G.

    1995-04-01

    The influence of radially sheared toroidal flows on the Trapped Ion Mode (TIM) is investigated using a two-dimensional eigenmode code. These radially extended toroidal microinstabilities could significantly influence the interpretation of confinement scaling trends and associated fluctuation properties observed in recent tokamak experiments. In the present analysis, the electrostatic drift kinetic equation is obtained from the general nonlinear gyrokinetic equation in rotating plasmas. In the long perpendicular wavelength limit k{sub {tau}}{rho}{sub bi} {much_lt} 1, where {rho}{sub bi} is the average trapped-ion banana width, the resulting eigenmode equation becomes a coupled system of second order differential equations nmo for the poloidal harmonics. These equations are solved using finite element methods. Numerical results from the analysis of low and medium toroidal mode number instabilities are presented using representative TFTR L-mode input parameters. To illustrate the effects of mode coupling, a case is presented where the poloidal mode coupling is suppressed. The influence of toroidal rotation on a TFTR L-mode shot is also analyzed by including a beam species with considerable larger temperature. A discussion of the numerical results is presented.

  10. Integrative decomposition procedure and Kappa statistics set up ATF2 ion binding module in malignant pleural mesothelioma (MPM)

    Institute of Scientific and Technical Information of China (English)

    Ying SUN; Lin WANG; Lei LIU

    2008-01-01

    Activating transcription factor 2 (ATF2) is a member of the ATF/cyclic AMP-responsive element bind-ing protein family of transcription factors. However, the information concerning ATF2 ion-mediated DNA binding module and function of ATF2 in malignant pleural mesothelioma (MPM) has never been addressed. In this study, by using GRNInfer and GVedit based on linear pro-gramming and a decomposition procedure, with integrated analysis of the function cluster using Kappa statistics and fuzzy heuristic clustering in MPM, we identified one ATF2 ion-mediated DNA binding module involved in invasive function including ATF2 inhibition to target genes FALZ, C20orf31, NME2, PLOD2, RNF10, and RNASEH1, upstream RNF10 and PLOD2 activation to ATF2, upstream RNASEH1 and FALZ inhibition to ATF2 from 40 MPM tumors and 5 normal pleural tissues. Remarkably, our results showed that the predominant effect of ATF2 occupancy is to suppress the activation of target genes on MPM. Importantly, the ATF2 ion-mediated DNA binding module reflects 'mutual' positive and negative feedback regulation mechanism of ATF2 with up-and down-stream genes. It may be useful for developing novel prognostic markers and therapeutic targets in MPM.

  11. The loss of activating transcription factor 4 (ATF4) reduces bone toughness and fracture toughness.

    Science.gov (United States)

    Makowski, Alexander J; Uppuganti, Sasidhar; Wadeer, Sandra A; Whitehead, Jack M; Rowland, Barbara J; Granke, Mathilde; Mahadevan-Jansen, Anita; Yang, Xiangli; Nyman, Jeffry S

    2014-05-01

    Even though age-related changes to bone tissue affecting fracture risk are well characterized, only a few matrix-related factors have been identified as important to maintaining fracture resistance. As a gene critical to osteoblast differentiation, activating transcription factor 4 (ATF4) is possibly one of these important factors. To test the hypothesis that the loss of ATF4 affects the fracture resistance of bone beyond bone mass and structure, we harvested bones from Atf4+/+ and Atf4-/- littermates at 8 and 20 weeks of age (n≥9 per group) for bone assessment across several length scales. From whole bone mechanical tests in bending, femurs from Atf4-/- mice were found to be brittle with reduced toughness and fracture toughness compared to femurs from Atf4+/+ mice. However, there were no differences in material strength and in tissue hardness, as determined by nanoindentation, between the genotypes, irrespective of age. Tissue mineral density of the cortex at the point of loading as determined by micro-computed tomography was also not significantly different. However, by analyzing local composition by Raman Spectroscopy (RS), bone tissue of Atf4-/- mice was found to have higher mineral to collagen ratio compared to wild-type tissue, primarily at 20 weeks of age. From RS analysis of intact femurs at 2 orthogonal orientations relative to the polarization axis of the laser, we also found that the organizational-sensitive peak ratio, ν1Phosphate per Amide I, changed to a greater extent upon bone rotation for Atf4-deficient tissue, implying bone matrix organization may contribute to the brittleness phenotype. Target genes of ATF4 activity are not only important to osteoblast differentiation but also in maintaining bone toughness and fracture toughness.

  12. Scenarios for the ATF2 Ultra-Low Betas Proposal

    Energy Technology Data Exchange (ETDEWEB)

    Marin, Eduardo; /CERN; Tomas, Rogelio; /CERN; Bambade, Philip; /Orsay, LAL; Kuroda, Shigeru; /KEK, Tsukuba; Okugi, Toshiyuki; /KEK, Tsukuba; Tauchi, Toshiaki; /KEK, Tsukuba; Terunuma, Nobuhiro; /KEK, Tsukuba; Urakawa, Junji; /KEK, Tsukuba; Parker, Brett; /Brookhaven; Seryi, Andrei; /SLAC; White, Glen; /SLAC; Woodley, Mark; /SLAC

    2012-06-29

    The current ATF2 Ultra-Low beta proposal was designed to achieve 20nm vertical IP beam size without considering the multipolar components of the FD magnets. In this paper we describe different scenarios that avoid the detrimental effect of these multipolar errors to the beam size at the interaction point (IP). The simplest approach consists in modifying the optics, but other solutions are studied as the introduction of super-conducting wigglers to reduce the emittance or the replacement of the normal-conducting focusing quadrupole in the Final Doublet (NC-QF1FF) with a super-conducting quadrupole one (SC-QF1FF). These are fully addressed in the paper.

  13. Effects of magnetic field perturbations in the ATF torsatron

    Energy Technology Data Exchange (ETDEWEB)

    Colchin, R.J.; England, A.C.; Isler, R.C.; Murakami, M.; Rasmussen, D.A.; Uckan, T.; Wilgen, J.B. [Oak Ridge National Lab., TN (United States); Aceto, S.C.; Zielinski, J.J. [Rensselaer Polytechnic Inst., Troy, NY (United States)

    1993-10-01

    The effects of errors in the magnetic fields of tokamaks on the plasma are quite different from those in stellarators. In tokamaks, field errors can cause disruptive locked modes through the non-linear evolution of tearing modes acting on initially small error-induced islands. Scaling predictions for these effects indicate that the critical relative field error which can be tolerated becomes smaller as the tokamak size becomes larger. In stellarators, the effect is more benign, as field errors appear only to cause increased plasma transport in the vicinity of islands. Great care has been taken to minimize magnetic field errors in the most recent generation of stellarator-type magnetic plasma traps. In the past six years, several new and sensitive techniques have been developed to detect and map field errors. These methods all rely on the detection of electrons injected along magnetic field lines. During the commissioning of ATF, flux surfaces were mapped using the fluorescent screen technique. Field errors were discovered and traced to uncompensated dipoles in the helical current feeds. Prior to elimination of these errors, plasma discharges indicated centrally peaked plasma profiles. After correction of the uncompensated dipoles, flux surfaces were mapped a second time, and the island widths were found to be greatly reduced. Field errors were then deliberately introduced using a set of perturbation coils that had been added to ATF, and electron-beam mapping of the flux surfaces showed that islands several centimeters in width could easily be created by these coils. After elimination of the error fields, the measured plasma temperature and density profiles were much broader. The field-perturbation coils were then used to produce magnetic field asymmetries, and the measured plasma profiles were again shown to narrow as a result of islands.

  14. Dynamical model for the toroidal sporadic meteors

    Energy Technology Data Exchange (ETDEWEB)

    Pokorný, Petr; Vokrouhlický, David [Institute of Astronomy, Charles University, V Holešovičkách 2, CZ-18000 Prague 8 (Czech Republic); Nesvorný, David [Department of Space Studies, Southwest Research Institute, 1050 Walnut Street, Suite 300, Boulder, CO 80302 (United States); Campbell-Brown, Margaret; Brown, Peter, E-mail: petr.pokorny@volny.cz, E-mail: vokrouhl@cesnet.cz, E-mail: davidn@boulder.swri.edu, E-mail: margaret.campbell@uwo.ca, E-mail: pbrown@uwo.ca [Department of Physics and Astronomy, University of Western Ontario, London, ON N6A 3K7 (Canada)

    2014-07-01

    More than a decade of radar operations by the Canadian Meteor Orbit Radar have allowed both young and moderately old streams to be distinguished from the dispersed sporadic background component. The latter has been categorized according to broad radiant regions visible to Earth-based observers into three broad classes: the helion and anti-helion source, the north and south apex sources, and the north and south toroidal sources (and a related arc structure). The first two are populated mainly by dust released from Jupiter-family comets and new comets. Proper modeling of the toroidal sources has not to date been accomplished. Here, we develop a steady-state model for the toroidal source of the sporadic meteoroid complex, compare our model with the available radar measurements, and investigate a contribution of dust particles from our model to the whole population of sporadic meteoroids. We find that the long-term stable part of the toroidal particles is mainly fed by dust released by Halley type (long period) comets (HTCs). Our synthetic model reproduces most of the observed features of the toroidal particles, including the most troublesome low-eccentricity component, which is due to a combination of two effects: particles' ability to decouple from Jupiter and circularize by the Poynting-Robertson effect, and large collision probability for orbits similar to that of the Earth. Our calibrated model also allows us to estimate the total mass of the HTC-released dust in space and check the flux necessary to maintain the cloud in a steady state.

  15. Specifications of the octupole magnets required for the ATF2 ultra-low ß* lattice

    Energy Technology Data Exchange (ETDEWEB)

    Marin, E.; /SLAC; Modena, M.; /CERN; Tauchi, T.; Terunuma, N.; /KEK, Tsukuba; Tomas, R.; /CERN; White, G.R.; /SLAC

    2014-05-28

    The Accelerator Test Facility 2 (ATF2) aims to test the novel chromaticity correction for higher chromaticity lattices as the one of CLIC. To this end the ATF2 ultra-low ß* lattice is designed to vertically focus the beam at the focal point or usually referred to as interaction point (IP), down to 23 nm. However when the measured multipole components of the ATF2 magnets are considered in the simulations, the evaluated spot sizes at the IP are well above the design value. The designed spot size is effectively recovered by inserting a pair of octupole magnets. In this note we address the technical specifications required for these octupole magnets.

  16. ATF CO{sub 2} laser system upgrade to terawatt peak power

    Energy Technology Data Exchange (ETDEWEB)

    Pogorelsky, I.V.

    1995-05-01

    This document describes the proposed upgrade of the 10-GW peak power 50-ps CO{sub 2} laser presently operational at the ATF to the 1 TW level at a shorter, 3--10 ps, pulse duration. The approach adopted is based on state of the art CO{sub 2} laser technology and an experience gained in the course of the ATF laser design and application for the laser accelerator experiment. The proposed upgrade is an economical way for the ATF to become in a short time among leading users facilities available for next generation ({ge} 100 MeV) laser accelerator studies.

  17. Toroidal dipole excitations in metamolecules formed by interacting plasmonic nanorods

    CERN Document Server

    Watson, Derek W; Ruostekoski, Janne; Fedotov, Vassili A; Zheludev, Nikolay I

    2015-01-01

    We show how the elusive toroidal dipole moment appears as a radiative excitation eigenmode in a metamolecule resonator that is formed by pairs of plasmonic nanorods. We analyze one such nanorod configuration - a toroidal metamolecule. We find that the radiative interactions in the toroidal metamolecule can be qualitatively represented by a theoretical model based on an electric point dipole arrangement. Both a finite-size rod model and the point dipole approximation demonstrate how the toroidal dipole moment is subradiant and difficult to excite by incident light. By means of breaking the geometric symmetry of the metamolecule, the toroidal mode can be excited by linearly polarized light and we provide simple optimization protocols for maximizing the toroidal dipole mode excitation. This opens up possibilities for simplified control and driving of metamaterial arrays consisting of toroidal dipole unit-cell resonators.

  18. ATF3 expression is induced by low glucose in pancreatic α and β cells and regulates glucagon but not insulin gene transcription.

    Science.gov (United States)

    Lee, Yong-Soo; Kobayashi, Masaki; Kikuchi, Osamu; Sasaki, Tsutomu; Yokota-Hashimoto, Hiromi; Susanti, Vina Yanti; Ido Kitamura, Yukari; Kitamura, Tadahiro

    2014-01-01

    The pancreas is critical for maintaining glucose homeostasis. Activating transcription factor 3 (ATF3) is an adaptive response transcription factor. There are major discrepancies in previous reports on pancreatic ATF3; therefore, its role in the pancreas is unclear. To better elucidate the role of ATF3 in the pancreas, we conducted in vitro studies using pancreatic α and β cell lines, and also evaluated the use of ATF3 antibodies for immunohistochemistry. We determined ATF3 expression was increased by low glucose and decreased by high glucose in both αTC-1.6 and βTC3 cells. We also showed that adenovirus-mediated ATF3 overexpression increased glucagon promoter activity and glucagon mRNA levels in αTC-1.6 cells; whereas, it had no effect on insulin promoter activity and insulin mRNA levels in βTC3 cells. Although immunostaining with the C-19 ATF3 antibody demonstrated predominant expression in α cells rather than β cells, ATF3 staining was still detected in ATF3 knockout mice as clearly as in control mice. On the other hand, another ATF3 antibody (H-90) detected ATF3 in both α cells and β cells, and was clearly diminished in ATF3 knockout mice. These results indicate that previous discrepancies in ATF3 expression patterns in the pancreas were caused by the varying specificities of the ATF3 antibodies used, and that ATF3 is actually expressed in both α cells and β cells.

  19. Modeling the rapid de-swelling of toroidal hydrogels

    Science.gov (United States)

    Nikolov, Svetoslav; Chang, Ya-Wen; Alexeev, Alexander; Fernandez de Las Nieves, Alberto

    2015-03-01

    The utilization of synthetic hydrogel networks as 3-D cell culture platforms has allowed researchers to more effectively study how epigenetic factors affect cell growth and physiology. As a whole, this has emphasized the biomechanical role of scaffold structures and led to a number of advances in tissue engineering. Our current research focuses on modeling temperature activated shape transformations of toroidal poly(N-isopropylacrylamide) pNIPAM gels. We use dissipative particle dynamics (DPD) to simulate the steady (slow heating rates) and unsteady (fast heating rates) de-swelling behavior of these thermo-sensitive gels. Our simulations show that for slow heating rates the aspect ratio of the tori remains constant during de-swelling. For rapid heating rates we observe buckling instabilities. Our simulations agree with the experimental observations. Financial support by NSF CAREER Award DMR-1255288 is gratefully acknowledged.

  20. ATF3, an HTLV-1 bZip factor binding protein, promotes proliferation of adult T-cell leukemia cells

    Directory of Open Access Journals (Sweden)

    Ohshima Koichi

    2011-03-01

    Full Text Available Abstract Background Adult T-cell leukemia (ATL is an aggressive malignancy of CD4+ T-cells caused by human T-cell leukemia virus type 1 (HTLV-1. The HTLV-1 bZIP factor (HBZ gene, which is encoded by the minus strand of the viral genome, is expressed as an antisense transcript in all ATL cases. By using yeast two-hybrid screening, we identified activating transcription factor 3 (ATF3 as an HBZ-interacting protein. ATF3 has been reported to be expressed in ATL cells, but its biological significance is not known. Results Immunoprecipitation analysis confirmed that ATF3 interacts with HBZ. Expression of ATF3 was upregulated in ATL cell lines and fresh ATL cases. Reporter assay revealed that ATF3 could interfere with the HTLV-1 Tax's transactivation of the 5' proviral long terminal repeat (LTR, doing so by affecting the ATF/CRE site, as well as HBZ. Suppressing ATF3 expression inhibited proliferation and strongly reduced the viability of ATL cells. As mechanisms of growth-promoting activity of ATF3, comparative expression profiling of ATF3 knockdown cells identified candidate genes that are critical for the cell cycle and cell death, including cell division cycle 2 (CDC2 and cyclin E2. ATF3 also enhanced p53 transcriptional activity, but this activity was suppressed by HBZ. Conclusions Thus, ATF3 expression has positive and negative effects on the proliferation and survival of ATL cells. HBZ impedes its negative effects, leaving ATF3 to promote proliferation of ATL cells via mechanisms including upregulation of CDC2 and cyclin E2. Both HBZ and ATF3 suppress Tax expression, which enables infected cells to escape the host immune system.

  1. Solar concentrator with a toroidal relay module.

    Science.gov (United States)

    Lin, Jhe-Syuan; Liang, Chao-Wen

    2015-10-01

    III-V multijunction solar cells require solar concentrators with a high concentration ratio to reduce per watt cost and to increase solar energy transforming efficiency. This paper discusses a novel solar concentrator design that features a high concentration ratio, high transfer efficiency, thin profile design, and a high solar acceptance angle. The optical design of the concentrator utilizes a toroidal relay module, which includes both the off-axis relay lens and field lens design in a single concentric toroidal lens shape. The optical design concept of the concentrator is discussed and the simulation results are shown. The given exemplary design has an aspect ratio of 0.24, a high averaged optical concentration ratio 1230×, a maximum efficiency of 76.8%, and the solar acceptance angle of ±0.9°.

  2. Reynolds stress of localized toroidal modes

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Y.Z. [International Center for Theoretical Studies, Trieste (Italy); Mahajan, S.M. [Univ. of Texas, Austin, TX (United States). Institute for Fusion Studies

    1995-02-01

    An investigation of the 2D toroidal eigenmode problem reveals the possibility of a new consistent 2D structure, the dissipative BM-II mode. In contrast to the conventional ballooning mode, the new mode is poloidally localized at {pi}/2 (or -{pi}/2), and possesses significant radial asymmetry. The radial asymmetry, in turn, allows the dissipative BM-II to generate considerably larger Reynolds stress as compared to the standard slab drift type modes. It is also shown that a wide class of localized dissipative toroidal modes are likely to be of the dissipative BM-II nature, suggesting that at the tokamak edge, the fluctuation generated Reynolds stress (a possible source of poloidal flow) can be significant.

  3. Physics of collapses in toroidal helical plasmas

    Energy Technology Data Exchange (ETDEWEB)

    Itoh, Kimitaka [National Inst. for Fusion Science, Toki, Gifu (Japan); Itoh, Sanae; Fukuyama, Atsushi; Yagi, Masatoshi

    1998-12-31

    Theoretical model for the collapse events in toroidal helical plasmas with magnetic hill is presented. There exists a turbulent-turbulent transition at a critical pressure gradient, leading to a sudden increase of the anomalous transport. When the magnetic shear is low, the nonlinear excitation of the global mode is possible. This model explains an abrupt growth of the perturbations, i.e., the trigger phenomena. Achievable limit of the plasma beta value is discussed. (author)

  4. Sumoylation delays the ATF7 transcription factor subcellular localization and inhibits its transcriptional activity.

    Science.gov (United States)

    Hamard, Pierre-Jacques; Boyer-Guittaut, Michaël; Camuzeaux, Barbara; Dujardin, Denis; Hauss, Charlotte; Oelgeschläger, Thomas; Vigneron, Marc; Kedinger, Claude; Chatton, Bruno

    2007-01-01

    Over the past few years, small ubiquitin-like modifier (SUMO) modification has emerged as an important regulator of diverse pathways and activities including protein localization and transcriptional regulation. We identified a consensus sumoylation motif (IKEE), located within the N-terminal activation domain of the ATF7 transcription factor and thus investigated the role of this modification. ATF7 is a ubiquitously expressed transcription factor, homologous to ATF2, that binds to CRE elements within specific promoters. This protein is able to heterodimerize with Jun or Fos proteins and its transcriptional activity is mediated by interaction with TAF12, a subunit of the general transcription factor TFIID. In the present article, we demonstrate that ATF7 is sumoylated in vitro (using RanBP2 as a E3-specific ligase) and in vivo. Moreover, we show that ATF7 sumoylation affects its intranuclear localization by delaying its entry into the nucleus. Furthermore, SUMO conjugation inhibits ATF7 transactivation activity by (i) impairing its association with TAF12 and (ii) blocking its binding-to-specific sequences within target promoters.

  5. Atf6 plays protective and pathologic roles in fatty liver disease due to endoplasmic reticulum stress

    Science.gov (United States)

    Cinaroglu, Ayca; Gao, Chuan; Imrie, Dru; Sadler, Kirsten C.

    2011-01-01

    Many etiologies of fatty liver disease (FLD) are associated with hyper-activation of one of the three pathways that comprise the unfolded protein response (UPR), a harbinger of endoplasmic reticulum (ER) stress. The UPR is mediated by pathways initiated by PERK, IRE1a/XBP1and ATF6, and each of these pathways have been implicated as either protective or pathological in FLD. We use zebrafish with FLD and hepatic ER stress to explore the relationship between Atf6 and steatosis. Mutation of the foie gras (foigr) gene causes FLD and hepatic ER stress. Prolonged treatment of wild-type larvae with a dose of tunicamycin that causes chronic ER stress phenocopies foigr. In contrast, acute exposure to a high dose of tunicamycin robustly activates the UPR but is less effective at inducing steatosis. The Srebp transcription factors are not required for steatosis in any of these models. Instead, depleting larvae of active Atf6 either through mbtps1 mutation or atf6 morpholino injection protects against steatosis caused by chronic ER stress whereas it exacerbates steatosis caused by acute tunicamycin treatment. Conclusion ER stress causes FLD. Loss of Atf6 prevents steatosis caused by chronic ER stress but can also potentiate steatosis caused by acute ER stress. This demonstrates that Atf6 can play both protective and pathological roles in FLD. PMID:21538441

  6. Aspects of Tokamak toroidal magnet protection

    Energy Technology Data Exchange (ETDEWEB)

    Green, R.W.; Kazimi, M.S.

    1979-07-01

    Simple but conservative geometric models are used to estimate the potential for damage to a Tokamak reactor inner wall and blanket due to a toroidal magnet field collapse. The only potential hazard found to exist is due to the MHD pressure rise in a lithium blanket. A survey is made of proposed protection methods for superconducting toroidal magnets. It is found that the two general classifications of protection methods are thermal and electrical. Computer programs were developed which allow the toroidal magnet set to be modeled as a set of circular filaments. A simple thermal model of the conductor was used which allows heat transfer to the magnet structure and which includes the effect of temperature dependent properties. To be effective in large magnets an electrical protection system should remove at least 50% of the stored energy in the protection circuit assuming that all of the superconductor in the circuit quenches when the circuit is activated. A protection system design procedure based on this criterion was developed.

  7. Complexes containing activating transcription factor (ATF)/cAMP-responsive-element-binding protein (CREB) interact with the CCAAT/enhancer-binding protein (C/EBP)-ATF composite site to regulate Gadd153 expression during the stress response.

    Science.gov (United States)

    Fawcett, T W; Martindale, J L; Guyton, K Z; Hai, T; Holbrook, N J

    1999-01-01

    Gadd153, also known as chop, encodes a member of the CCAAT/enhancer-binding protein (C/EBP) transcription factor family and is transcriptionally activated by cellular stress signals. We recently demonstrated that arsenite treatment of rat pheochromocytoma PC12 cells results in the biphasic induction of Gadd153 mRNA expression, controlled in part through binding of C/EBPbeta and two uncharacterized protein complexes to the C/EBP-ATF (activating transcription factor) composite site in the Gadd153 promoter. In this report, we identified components of these additional complexes as two ATF/CREB (cAMP-responsive-element-binding protein) transcription factors having differential binding activities dependent upon the time of arsenite exposure. During arsenite treatment of PC12 cells, we observed enhanced binding of ATF4 to the C/EBP-ATF site at 2 h as Gadd153 mRNA levels increased, and enhanced binding of ATF3 complexes at 6 h as Gadd153 expression declined. We further demonstrated that ATF4 activates, while ATF3 represses, Gadd153 promoter activity through the C/EBP-ATF site. ATF3 also repressed ATF4-mediated transactivation and arsenite-induced activation of the Gadd153 promoter. Our results suggest that numerous members of the ATF/CREB family are involved in the cellular stress response, and that regulation of stress-induced biphasic Gadd153 expression in PC12 cells involves the ordered, sequential binding of multiple transcription factor complexes to the C/EBP-ATF composite site. PMID:10085237

  8. An overview on research developments of toroidal continuously variable transmissions

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    As environmental protection agencies enact new regulations for automotive fuel economy and emission, the toroidal continuously variable transmissions (CVTs) keep on contribute to the advent of system technologies for better fuel consumption of automobiles with internal combustion engines (ICE). Toroidal CVTs use infinitely adjustable drive ratios instead of stepped gears to achieve optimal performance. Toroidal CVTs are one of the earliest patents to the automotive world but their torque capacities and reliability have limitations in the past. New developments and implementations in the control strategies, and several key technologies have led to development of more robust toroidal CVTs, which enables more extensive automotive application of toroidal CTVs. This paper concerns with the current development, upcoming and progress set in the context of the past development and the traditional problems associated with toroidal CVTs.

  9. Toroid cavity/coil NMR multi-detector

    Science.gov (United States)

    Gerald, II, Rex E.; Meadows, Alexander D.; Gregar, Joseph S.; Rathke, Jerome W.

    2007-09-18

    An analytical device for rapid, non-invasive nuclear magnetic resonance (NMR) spectroscopy of multiple samples using a single spectrometer is provided. A modified toroid cavity/coil detector (TCD), and methods for conducting the simultaneous acquisition of NMR data for multiple samples including a protocol for testing NMR multi-detectors are provided. One embodiment includes a plurality of LC resonant circuits including spatially separated toroid coil inductors, each toroid coil inductor enveloping its corresponding sample volume, and tuned to resonate at a predefined frequency using a variable capacitor. The toroid coil is formed into a loop, where both ends of the toroid coil are brought into coincidence. Another embodiment includes multiple micro Helmholtz coils arranged on a circular perimeter concentric with a central conductor of the toroid cavity.

  10. ATF7 is stabilized during mitosis in a CDK1-dependent manner and contributes to cyclin D1 expression.

    Science.gov (United States)

    Schaeffer, Etienne; Vigneron, Marc; Sibler, Annie-Paule; Oulad-Abdelghani, Mustapha; Chatton, Bruno; Donzeau, Mariel

    2015-01-01

    The transcription factor ATF7 undergoes multiple post-translational modifications, each of which has distinct effects upon ATF7 function. Here, we show that ATF7 phosphorylation on residue Thr112 exclusively occurs during mitosis, and that ATF7 is excluded from the condensed chromatin. Both processes are CDK1/cyclin B dependent. Using a transduced neutralizing monoclonal antibody directed against the Thr112 epitope in living cells, we could demonstrate that Thr112 phosphorylation protects endogenous ATF7 protein from degradation, while it has no effect on the displacement of ATF7 from the condensed chromatin. The crucial role of Thr112 phosphorylation in stabilizing ATF7 protein during mitosis was confirmed using phospho-mimetic and phospho-deficient mutants. Finally, silencing ATF7 by CRISPR/Cas9 technology leads to a decrease of cyclin D1 protein expression levels. We propose that mitotic stabilized ATF7 protein re-localizes onto chromatin at the end of telophase and contributes to induce the cyclin D1 gene expression.

  11. Landau damping of geodesic acoustic mode in toroidally rotating tokamaks

    Energy Technology Data Exchange (ETDEWEB)

    Ren, Haijun, E-mail: hjren@ustc.edu.cn [CAS Key Laboratory of Geospace Environment, The Collaborative Innovation Center for Advanced Fusion Energy and Plasma Science, and Department of Modern Physics, University of Science and Technology of China, Hefei 230026 (China); Cao, Jintao [Bejing National Laboratory for Condensed Matter Physics and CAS Key Laboratory of Soft Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100190 (China)

    2015-06-15

    Geodesic acoustic mode (GAM) is analyzed by using modified gyro-kinetic (MGK) equation applicable to low-frequency microinstabilities in a rotating axisymmetric plasma. Dispersion relation of GAM in the presence of arbitrary toroidal Mach number is analytically derived. The effects of toroidal rotation on the GAM frequency and damping rate do not depend on the orientation of equilibrium flow. It is shown that the toroidal Mach number M increases the GAM frequency and dramatically decreases the Landau damping rate.

  12. 3D Printing the ATLAS' barrel toroid

    CERN Document Server

    Goncalves, Tiago Barreiro

    2016-01-01

    The present report summarizes my work as part of the Summer Student Programme 2016 in the CERN IR-ECO-TSP department (International Relations – Education, Communication & Outreach – Teacher and Student Programmes). Particularly, I worked closely with the S’Cool LAB team on a science education project. This project included the 3D designing, 3D printing, and assembling of a model of the ATLAS’ barrel toroid. A detailed description of the project' development is presented and a short manual on how to use 3D printing software and hardware is attached.

  13. Toroidal membrane vesicles in spherical confinement

    CERN Document Server

    Bouzar, Lila; Müller, Martin Michael

    2015-01-01

    We investigate the morphology of a toroidal fluid membrane vesicle confined inside a spherical container. The equilibrium shapes are assembled in a geometrical phase diagram as a function of scaled area and reduced volume of the membrane. For small area the vesicle can adopt its free form. When increasing the area, the membrane cannot avoid contact and touches the confining sphere along a circular contact line, which extends to a zone of contact for higher area. The elastic energies of the equilibrium shapes are compared to those of their confined counterparts of spherical topology to predict under which conditions a topology change is favored energetically.

  14. Toroidal membrane vesicles in spherical confinement

    Science.gov (United States)

    Bouzar, Lila; Menas, Ferhat; Müller, Martin Michael

    2015-09-01

    We investigate the morphology of a toroidal fluid membrane vesicle confined inside a spherical container. The equilibrium shapes are assembled in a geometrical phase diagram as a function of scaled area and reduced volume of the membrane. For small area the vesicle can adopt its free form. When increasing the area, the membrane cannot avoid contact and touches the confining sphere along a circular contact line, which extends to a zone of contact for higher area. The elastic energies of the equilibrium shapes are compared to those of their confined counterparts of spherical topology to predict under which conditions a topology change is favored energetically.

  15. Permanent magnetic toroidal drive with half stator

    Directory of Open Access Journals (Sweden)

    Lizhong Xu

    2017-01-01

    Full Text Available A permanent magnetic toroidal drive with a half stator is proposed that avoids noise and mechanical vibrations. The effects of the system parameters on the output torque of the drive were investigated. A model machine was designed and produced. The output torque and speed fluctuation of the drive system were measured, and the calculated and measured output torque were compared. The tests demonstrated that the drive system could operate continuously without noise, and the system achieved a given speed ratio. The drive system had high load-carrying ability and a maximum output torque of 0.15 N m when certain parameter values were used.

  16. Polar interface phonons in ionic toroidal systems.

    Science.gov (United States)

    Nguyen, N D; Evrard, R; Stroscio, Michael A

    2016-09-01

    We use the dielectric continuum model to obtain the polar (Fuchs-Kliewer like) interface vibration modes of toroids made of ionic materials either embedded in a different material or in vacuum, with applications to nanotoroids specially in mind. We report the frequencies of these modes and describe the electric potential they produce. We establish the quantum-mechanical Hamiltonian appropriate for their interaction with electric charges. This Hamiltonian can be used to describe the effect of this interaction on different types of charged particles either inside or outside the torus.

  17. A Novel superconducting toroidal field magnet concept using advanced materials

    Science.gov (United States)

    Schwartz, J.

    1992-03-01

    The plasma physics database indicates that two distinct approaches to tokamak design may lead to commercial fusion reactors: low Aspect ratio, high plasma current, relatively low magnetic field devices, and high Aspect ratio, high field devices. The former requires significant enhancements in plasma performance, while the latter depends primarily upon technology development. The key technology for the commercialization of the high-field approach is large, high magnetic field superconducting magnets. In this paper, the physics motivation for the high field approach and key superconducting magnet (SCM) development issues are reviewed. Improved SCM performance may be obtained from improved materials and/or improved engineering. Superconducting materials ranging from NbTi to high- T c oxides are reviewed, demonstrating the broad range of potential superconducting materials. Structural material options are discussed, including cryogenic steel alloys and fiber-reinforced composite materials. Again, the breadth of options is highlighted. The potential for improved magnet engineering is quantified in terms of the Virial Theorem Limit, and two examples of approaches to highly optimized magnet configurations are discussed. The force-reduced concept, which is a finite application of the force-free solutions to Ampere's Law, appear promising for large SCMs but may be limited by the electromagnetics of a fusion plasma. The Solid Superconducting Cylinder (SSC) concept is proposed. This concept combines the unique properties of high- T c superconductors within a low- T c SCM to obtain (1) significant reductions in the structural material volume, (2) a decoupling of the tri-axial (compressive and tensile) stress state, and (3) a demountable TF magnet system. The advantages of this approach are quantified in terms of a 24 T commercial reactor TF magnet system. Significant reductions in the mechanical stress and the TF radial build are demonstrated.

  18. Quench propagation and protection analysis of the ATLAS Toroids

    CERN Document Server

    Dudarev, A; ten Kate, H H J; Baynham, D Elwyn; Courthold, M J D; Lesmond, C

    2000-01-01

    The ATLAS superconducting magnet system consists of the Barrel Toroid, two End Cap Toroids and the Central Solenoid. However, the Toroids of eight coils each are magnetically separate systems to the Central Solenoid. The Toroids are electrically connected in series and energized by a single power supply. The quench protection system is based on the use of relatively small external dump resistances in combination with quench-heaters activated after a quench event detection to initiate the internal dump of stored energy in all the coils. A rather strong quench-back effect due to eddy-currents in the coil casings at the transport current decay is beneficial for the quench protection efficiency in the event of heater failures. The quench behaviour of the ATLAS Toroids was computer simulated for normal operation of the quench protection system and its complete non-operation (failure) mode. (3 refs).

  19. Formation of a compact toroid for enhanced efficiency

    Energy Technology Data Exchange (ETDEWEB)

    Mozgovoy, A. G. [P.N. Lebedev Physical Institute, Moscow 119991 (Russian Federation); Romadanov, I. V.; Ryzhkov, S. V., E-mail: ryzhkov@power.bmstu.ru [Bauman Moscow State Technical University, Moscow 105005 (Russian Federation)

    2014-02-15

    We report here our results on the formation of a plasma configuration with the generic name of compact toroid (CT). A method of compact toroid formation to confine, heat and compress a plasma is investigated. Formation of a compact torus using an additional toroidal magnetic field helps to increase the plasma current to a maintainable level of the original magnetic field. We design the Compact Toroid Challenge (CTC) experiment in order to improve the magnetic flux trapping during field reversal in the formation of a compact toroid. The level of the magnetic field immersed in the plasma about 70% of the primary field is achieved. The CTC device and scheme of high level capturing of magnetic flux are presented.

  20. ATF6 as a Transcription Activator of the Endoplasmic Reticulum Stress Element: Thapsigargin Stress-Induced Changes and Synergistic Interactions with NF-Y and YY1

    OpenAIRE

    Li, Mingqing; Baumeister, Peter; Roy, Binayak; Phan, Trevor; Foti, Dolly; Luo, Shengzhan; Lee, Amy S.

    2000-01-01

    ATF6, a member of the leucine zipper protein family, can constitutively induce the promoter of glucose-regulated protein (grp) genes through activation of the endoplasmic reticulum (ER) stress element (ERSE). To understand the mechanism of grp78 induction by ATF6 in cells subjected to ER calcium depletion stress mediated by thapsigargin (Tg) treatment, we discovered that ATF6 itself undergoes Tg stress-induced changes. In nonstressed cells, ATF6, which contains a putative short transmembrane ...

  1. Design of bunch compressing system with suppression of coherent synchrotron radiation for ATF upgrade

    Energy Technology Data Exchange (ETDEWEB)

    Jing, Yichao [Brookhaven National Lab. (BNL), Upton, NY (United States); Fedurin, Mikhail [Brookhaven National Lab. (BNL), Upton, NY (United States); Stratakis, Diktys [Brookhaven National Lab. (BNL), Upton, NY (United States)

    2015-05-03

    One of the operation modes for Accelerator Test Facility (ATF) upgrade is to provide high peak current, high quality electron beam for users. Such operation requires a bunch compressing system with a very large compression ratio. The CSR originating from the strong compressors generally could greatly degrade the quality of the electron beam. In this paper, we present our design for the entire bunch compressing system that will limit the effect of CSR on the e-beam’s quality. We discuss and detail the performance from the start to end simulation of such a compressor for ATF.

  2. The transcription factor ATF7 mediates lipopolysaccharide-induced epigenetic changes in macrophages involved in innate immunological memory.

    Science.gov (United States)

    Yoshida, Keisuke; Maekawa, Toshio; Zhu, Yujuan; Renard-Guillet, Claire; Chatton, Bruno; Inoue, Kentaro; Uchiyama, Takeru; Ishibashi, Ken-ichi; Yamada, Takuji; Ohno, Naohito; Shirahige, Katsuhiko; Okada-Hatakeyama, Mariko; Ishii, Shunsuke

    2015-10-01

    Immunological memory is thought to be mediated exclusively by lymphocytes. However, enhanced innate immune responses caused by a previous infection increase protection against reinfection, which suggests the presence of innate immunological memory. Here we identified an important role for the stress-response transcription factor ATF7 in innate immunological memory. ATF7 suppressed a group of genes encoding factors involved in innate immunity in macrophages by recruiting the histone H3K9 dimethyltransferase G9a. Treatment with lipopolysaccharide, which mimics bacterial infection, induced phosphorylation of ATF7 via the kinase p38, which led to the release of ATF7 from chromatin and a decrease in repressive histone H3K9me2 marks. A partially disrupted chromatin structure and increased basal expression of target genes were maintained for long periods, which enhanced resistance to pathogens. ATF7 might therefore be important in controlling memory in cells of the innate immune system.

  3. Shear-dependant toroidal vortex flow

    Energy Technology Data Exchange (ETDEWEB)

    Khorasani, Nariman Ashrafi; Haghighi, Habib Karimi [Payame Noor University, Tehran (Iran, Islamic Republic of)

    2013-01-15

    Pseudoplastic circular Couette flow in annulus is investigated. The flow viscosity is dependent on the shear rate, which directly affects the conservation equations that are solved in the present study by the spectral method in the present study. The pseudoplastic model adopted here is shown to be a suitable representative of nonlinear fluids. Unlike the previous studies, where only the square of shear rate term in the viscosity expression was considered to ease the numerical manipulations, in the present study takes the term containing the quadratic power into account. The curved streamlines of the circular Couette flow can cause a centrifugal instability leading to toroidal vortices, known as Taylor vortices. It is further found that the critical Taylor number becomes lower as the pseudoplastic effect increases. Comparison with existing measurements on pseudoplastic circular Couette flow results in good agreement.

  4. Helicity of the toroidal vortex with swirl

    CERN Document Server

    Bannikova, Elena Yu; Poslavsky, Sergey A

    2016-01-01

    On the basis of solutions of the Bragg-Hawthorne equations we discuss the helicity of thin toroidal vortices with the swirl - the orbital motion along the torus diretrix. It is shown that relationship of the helicity with circulations along the small and large linked circles - directrix and generatrix of the torus - depends on distribution of the azimuthal velocity in the core of the swirling vortex ring. In the case of non-homogeneous swirl this relationship differs from the well-known Moffat relationship - the doubled product of such circulations multiplied by the number of links. The results can be applied to vortices in planetary atmospheres and to vortex movements in the vicinity of active galactic nuclei.

  5. The theory of toroidally confined plasmas

    CERN Document Server

    White, Roscoe B

    2014-01-01

    This graduate level textbook develops the theory of magnetically confined plasma, with the aim of bringing the reader to the level of current research in the field of thermonuclear fusion. It begins with the basic concepts of magnetic field description, plasma equilibria and stability, and goes on to derive the equations for guiding center particle motion in an equilibrium field. Topics include linear and nonlinear ideal and resistive modes and particle transport. It is of use to workers in the field of fusion both for its wide-ranging account of tokamak physics and as a kind of handbook or formulary. This edition has been extended in a number of ways. The material on mode-particle interactions has been reformulated and much new information added, including methodology for Monte Carlo implementation of mode destabilization. These results give explicit means of carrying out mode destabilization analysis, in particular for the dangerous fishbone mode. A new chapter on cyclotron motion in toroidal geometry has ...

  6. Damping of toroidal ion temperature gradient modes

    Energy Technology Data Exchange (ETDEWEB)

    Sugama, H. [National Inst. for Fusion Science, Toki, Gifu (Japan)

    1999-04-01

    The temporal evolution of linear toroidal ion temperature gradient (ITG) modes is studied based on a kinetic integral equation including an initial condition. It is shown how to evaluate the analytic continuation of the integral kernel as a function of a complex-valued frequency, which is useful for analytical and numerical calculations of the asymptotic damping behavior of the ITG mode. In the presence of the toroidal {nabla}B-curvature drift, the temporal dependence of the density and potential perturbations consists of normal modes and a continuum mode, which correspond to contributions from poles and from an integral along a branch cut, respectively, of the Laplace-transformed potential function of the complex-valued frequency. The normal modes have exponential time dependence with frequencies and growth rates determined by the dispersion relation while the continuum mode, which has a ballooning structure, shows a power law decay {proportional_to} t{sup -2} in the asymptotic limit, where t is the time variable. Therefore, the continuum mode dominantly describes the long-time asymptotic behavior of the density and potential perturbations for the stable system where all normal modes have negative growth rates. By performing proper analytic continuation for the homogeneous version of the kinetic integral equation, dependences of the normal modes` growth rate, real frequency, and eigenfunction on {eta}{sub i} (the ratio of the ion temperature gradient to the density gradient), k{sub {theta}} (the poloidal wavenumber), s (the magnetic shear parameter), and {theta}{sub k} (the ballooning angle corresponding to the minimum radial wavenumber) are numerically obtained for both stable and unstable cases. (author)

  7. Concept design of the cassette toroidal mover

    Energy Technology Data Exchange (ETDEWEB)

    Maekinen, H., E-mail: harri.makinen@vtt.fi [VTT Technical Research Centre of Finland, P.O. Box 1300, FI-33101 Tampere (Finland); Jaervenpaeae, J. [VTT Technical Research Centre of Finland, P.O. Box 1300, FI-33101 Tampere (Finland); Valkama, P.; Vaeyrynen, J.; Amjad, F. [Tampere University of Technology, Korkeakoulunkatu 6, 33720 Tampere (Finland); Siuko, M. [VTT Technical Research Centre of Finland, P.O. Box 1300, FI-33101 Tampere (Finland); Mattila, J. [Tampere University of Technology, Korkeakoulunkatu 6, 33720 Tampere (Finland); Semeraro, L.; Esque, S. [Fusion for Energy, Torres Diagonal Litoral B3, Josep Pla 2, 08019 Barcelona (Spain)

    2011-10-15

    A full scale physical development and test facility, Divertor Test Platform 2 (DTP2), has been established in Finland for the purpose of demonstrating and developing the remote handling (RH) equipment designs for ITER using prototypes and virtual models. The major objective of the DTP2 environment is to verify and develop ITER divertor RH devices and operations. In practice this means various test trials and measurements of performance characteristics. This paper describes the design process of the Cassette Toroidal Mover (CTM). The main purpose of this design task was the development of the CTM concept. The goal of the design process was to achieve compatibility between CTM and the latest ITER divertor design. The design process was based on using a variety of tools, i.e. Catia V5, Delmia, Ansys, Mathcad and project management tools. Applicable European Standards were applied to the concept design. CTM is the cassette transporter, which carries divertor cassettes on the toroidal rails inside the ITER Vacuum Vessel (VV) during the divertor maintenance. The operation environment differs from a common industrial environment. Radiation level is 100 Gy/h. The temperature during RH operations can be 50 {sup o}C. Clearances are less than 20 mm and the loads carried weigh 9000 kg. These conditions require special solutions during the product development process. The design process consisted of defining and developing of the CTM operational sequence. This sequence includes the procedure of how the CTM - with it is onboard manipulator - prepares for and handles the divertor cassettes during RH operations. RH operations are essential part when defining CTM functions. High reliability is required in order to carry out RH tasks successfully. The recoverability of CTM is also an important design criteria. This paper describes the design process and the structure of the CTM concept.

  8. Petascale Parallelization of the Gyrokinetic Toroidal Code

    Energy Technology Data Exchange (ETDEWEB)

    Ethier, Stephane; Adams, Mark; Carter, Jonathan; Oliker, Leonid

    2010-05-01

    The Gyrokinetic Toroidal Code (GTC) is a global, three-dimensional particle-in-cell application developed to study microturbulence in tokamak fusion devices. The global capability of GTC is unique, allowing researchers to systematically analyze important dynamics such as turbulence spreading. In this work we examine a new radial domain decomposition approach to allow scalability onto the latest generation of petascale systems. Extensive performance evaluation is conducted on three high performance computing systems: the IBM BG/P, the Cray XT4, and an Intel Xeon Cluster. Overall results show that the radial decomposition approach dramatically increases scalability, while reducing the memory footprint - allowing for fusion device simulations at an unprecedented scale. After a decade where high-end computing (HEC) was dominated by the rapid pace of improvements to processor frequencies, the performance of next-generation supercomputers is increasingly differentiated by varying interconnect designs and levels of integration. Understanding the tradeoffs of these system designs is a key step towards making effective petascale computing a reality. In this work, we examine a new parallelization scheme for the Gyrokinetic Toroidal Code (GTC) [?] micro-turbulence fusion application. Extensive scalability results and analysis are presented on three HEC systems: the IBM BlueGene/P (BG/P) at Argonne National Laboratory, the Cray XT4 at Lawrence Berkeley National Laboratory, and an Intel Xeon cluster at Lawrence Livermore National Laboratory. Overall results indicate that the new radial decomposition approach successfully attains unprecedented scalability to 131,072 BG/P cores by overcoming the memory limitations of the previous approach. The new version is well suited to utilize emerging petascale resources to access new regimes of physical phenomena.

  9. Active toroidal field ripple compensation and MHD feedback control coils in FAST

    Energy Technology Data Exchange (ETDEWEB)

    Ramogida, G., E-mail: giuseppe.ramogida@enea.it [Associazione Euratom-ENEA sulla Fusione, ENEA – C.R. Frascati, Via E. Fermi 45, I-00044 Frascati, RM (Italy); Calabrò, G.; Cocilovo, V.; Crescenzi, F.; Crisanti, F.; Cucchiaro, A. [Associazione Euratom-ENEA sulla Fusione, ENEA – C.R. Frascati, Via E. Fermi 45, I-00044 Frascati, RM (Italy); Di Gironimo, G. [Associazione Euratom-ENEA, CREATE – Università di Napoli Federico II, Via Claudio 21, I-80125 Napoli (Italy); Fresa, R. [Università della Basilicata, Via Nazario Sauro 85, I-85100 Potenza (Italy); Fusco, V. [Associazione Euratom-ENEA sulla Fusione, ENEA – C.R. Frascati, Via E. Fermi 45, I-00044 Frascati, RM (Italy); Martin, P. [Associazione Euratom-ENEA, Consorzio RFX, Corso Stati Uniti 4, I-35127, Padova (Italy); Mastrostefano, S. [Associazione Euratom-ENEA, CREATE – DIEI Università di Cassino, Via Di Biasio 43, I-03043 Cassino, FR (Italy); Mozzillo, R. [Associazione Euratom-ENEA, CREATE – Università di Napoli Federico II, Via Claudio 21, I-80125 Napoli (Italy); Nuzzolese, F. [Università della Basilicata, Via Nazario Sauro 85, I-85100 Potenza (Italy); Renno, F. [Associazione Euratom-ENEA, CREATE – Università di Napoli Federico II, Via Claudio 21, I-80125 Napoli (Italy); Rita, C. [Associazione Euratom-ENEA sulla Fusione, ENEA – C.R. Frascati, Via E. Fermi 45, I-00044 Frascati, RM (Italy); Villone, F. [Associazione Euratom-ENEA, CREATE – DIEI Università di Cassino, Via Di Biasio 43, I-03043 Cassino, FR (Italy); Vlad, G. [Associazione Euratom-ENEA sulla Fusione, ENEA – C.R. Frascati, Via E. Fermi 45, I-00044 Frascati, RM (Italy)

    2013-10-15

    Highlights: ► Active Ripple Compensating System (ARCS) consists of 18 off-centre poloidal coils between plasma and Toroidal Field Coils. ► The current in ARCS, adjustable and opposite to that in TFC, reduces the toroidal ripple below 0.2% at any toroidal fields. ► Feedback Active Control System (FACS) consists of two arrays of 9 in-vessel saddle coils fed by an MHD feedback controller. ► FACS allows robust feedback stabilization of low toroidal number MHD modes enabling plasma operations at low safety factor. ► ARCS and FACS are included in the whole FAST model and first engineering assessments show their feasibility and capability. -- Abstract: The Fusion Advanced Study Torus (FAST) has been proposed as a high magnetic field, compact size tokamak providing a flexible integrated environment to study physics and technology issues in ITER and DEMO relevant conditions. FAST has a quite large natural toroidal field ripple (around 1.5%) due to its compactness and to the number of access ports: this ripple must be lowered to an acceptable level to allow safe operations and a good confinement quality. An Active Ripple Compensating System (ARCS) has been designed, based on a set of poloidal coils placed between the plasma chamber and the Toroidal Field Coils (TFCs). These ARCS coils will be fed with adjustable currents, opposite in direction respect to the TFC currents, and will allow lowering the ripple up to zero and beyond. The CAD model of FAST including the ARCS coils has been completed and preliminary electromagnetic and thermal analyses have been carried out. Moreover, a Feedback Active Control System (FACS) composed of two arrays of in-vessel saddle coils has been designed to allow safe high plasma current, low safety factor operation and to mitigate possibly large ELMs effects in FAST. These FACS coils will be fed by a feedback system to control MHD modes: a first engineering assessment of the current requirements has been carried out.

  10. ATF3 Expression in the corpus luteum: possible role in luteal regression

    Science.gov (United States)

    The present study investigated the induction and possible role of activating transcription factor 3 (ATF3) in the corpus luteum. Postpubertal cattle were treated at midcycle with prostaglandin F2alpha(PGF) for 0–4 hours. Luteal tissue was processed for immunohistochemistry, in situ hybridization, an...

  11. Mechanical Property and Oxidation Behavior of ATF cladding developed in KAERI

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Hyun-Gil; Kim, Il-Hyun; Jung, Yang-Il; Park, Dong-Jun; Park, Jung-Hwan; Park, Jeong-Yong; Koo, Yang-Hyun [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2015-10-15

    To realize the coating cladding, coating material (Cr-based alloy) as well as coating technology (3D laser coating and arc ion plating combined with vacuum annealing) can be developed to meet the fuel cladding criteria. The coated Zr cladding can be produced after the optimization of coating technologies. The coated cladding sample showed the good oxidation/corrosion and adhesion properties without the spalling and/or severe interaction with the Zr alloy cladding from the various tests. Thus, it is known that the mechanical property and oxidation behavior of coated cladding concept developed in KAERI is reasonable for applying the ATF cladding in LWRs. At the present time various ATF concepts have been proposed and developing in many countries. The ATF concepts with potentially improved accident performance can be summarized to the coating cladding, Mo-Zr cladding, FeCrAl cladding, and SiCf/SiC cladding. Regarding the cladding performance, ATF cladding concepts will be evaluated with respect to the accident scenarios and normal operations of LWRs as well as to the fuel cladding fabrication.

  12. Melatonin, a novel selective ATF-6 inhibitor, induces human hepatoma cell apoptosis through COX-2 downregulation

    Science.gov (United States)

    Bu, Li-Jia; Yu, Han-Qing; Fan, Lu-Lu; Li, Xiao-Qiu; Wang, Fang; Liu, Jia-Tao; Zhong, Fei; Zhang, Cong-Jun; Wei, Wei; Wang, Hua; Sun, Guo-Ping

    2017-01-01

    AIM To clarify the mechanisms involved in the critical endoplasmic reticulum (ER) stress initiating unfolded protein response pathway modified by melatonin. METHODS Hepatoma cells, HepG2, were cultured in vitro. Flow cytometry and TUNEL assay were used to measure HepG2 cell apoptosis. Western blotting and quantitative reverse transcription-polymerase chain reaction methods were used to determine the protein and messenger RNA levels of ER stress and apoptosis related genes’ expression, respectively. Tissue microarray construction from patients was verified by immunohistochemical analysis. RESULTS In the present study, we first identified that melatonin selectively blocked activating transcription factor 6 (ATF-6) and then inhibited cyclooxygenase-2 (COX-2) expression, leading to enhanced liver cancer cell apoptosis under ER stress condition. Dramatically increased CCAAT-enhancer-binding protein homologous protein level, suppressed COX-2 and decreased Bcl-2/Bax ratio by melatonin or ATF-6 siRNA contributed the enhanced HepG2 cell apoptosis under tunicamycin (an ER stress inducer) stimulation. In clinical hepatocellular carcinoma patients, the close relationship between ATF-6 and COX-2 was further confirmed. CONCLUSION These findings indicate that melatonin as a novel selective ATF-6 inhibitor can sensitize human hepatoma cells to ER stress inducing apoptosis. PMID:28246472

  13. Experimental and Theoretical Progress of Linear Collider Final Focus Design and ATF2 Facility

    CERN Document Server

    Seryi, Andrei; Zimmermann, Frank; Kubo, Kiyoshi; Kuroda, Shigeru; Okugi, Toshiyuki; Tauchi, Toshiaki; Terunuma, Nobuhiro; Urakawa, Junji; White, Glen; Woodley, Mark; Angal-Kalinin, Deepa

    2014-01-01

    In this brief overview we will reflect on the process of the design of the linear collider (LC) final focus (FF) optics, and will also describe the theoretical and experimental efforts on design and practical realisation of a prototype of the LC FF optics implemented in the ATF2 facility at KEK, Japan, presently being commissioned and operated.

  14. Reference Magnetic Coordinates (RMC) for toroidal confinement systems

    Science.gov (United States)

    Zakharov, Leonid; Kolemen, Egemen; Lazerson, Samuel

    2012-03-01

    Because of intrinsic anisotropy of high temperature plasma with respect to magnetic field, use of proper coordinates is of high priority for both theory and numerical methods. While in axisymmetric case, the poloidal flux function Y(r,z)=const determines proper flux coordinates, in 3-D, such a function does not exist. The destruction of nested magnetic surfaces even by small 3-D perturbations leads to a sudden change of topology of magnetic field. As a result, the coordinate systems can no longer be based on tracing the magnetic field lines resulting in difficulties for theory and 3-D numerical simulations. The RMC coordinates a,θ,ζ presented here (introduced in 1998 but not really used) are nested toroidal coordinates, which are best aligned with an ergodic confinement fields. In particular, in RMC the vector potential of the magnetic field has an irreducible form A = φ00(a)∇θ +[Y00(a) +ψ^*(a,θ,ζ)]∇ζ , where 3-D function ψ^* contains only resonant Fourier harmonics of angle coordinates. RMC can be generated and advanced using a fast (Newton) algorithm not involving the field line tracing.

  15. Social isolation stress induces ATF-7 phosphorylation and impairs silencing of the 5-HT 5B receptor gene.

    Science.gov (United States)

    Maekawa, Toshio; Kim, Seungjoon; Nakai, Daisuke; Makino, Chieko; Takagi, Tsuyoshi; Ogura, Hiroo; Yamada, Kazuyuki; Chatton, Bruno; Ishii, Shunsuke

    2010-01-06

    Many symptoms induced by isolation rearing of rodents may be relevant to neuropsychiatric disorders, including depression. However, identities of transcription factors that regulate gene expression in response to chronic social isolation stress remain elusive. The transcription factor ATF-7 is structurally related to ATF-2, which is activated by various stresses, including inflammatory cytokines. Here, we report that Atf-7-deficient mice exhibit abnormal behaviours and increased 5-HT receptor 5B (Htr5b) mRNA levels in the dorsal raphe nuclei. ATF-7 silences the transcription of Htr5B by directly binding to its 5'-regulatory region, and mediates histone H3-K9 trimethylation via interaction with the ESET histone methyltransferase. Isolation-reared wild-type (WT) mice exhibit abnormal behaviours that resemble those of Atf-7-deficient mice. Upon social isolation stress, ATF-7 in the dorsal raphe nucleus is phosphorylated via p38 and is released from the Htr5b promoter, leading to the upregulation of Htr5b. Thus, ATF-7 may have a critical role in gene expression induced by social isolation stress.

  16. ATF4 plays a pivotal role in the development of functional hematopoietic stem cells in mouse fetal liver.

    Science.gov (United States)

    Zhao, Yunze; Zhou, Jie; Liu, Dan; Dong, Fang; Cheng, Hui; Wang, Weili; Pang, Yakun; Wang, Yajie; Mu, Xiaohuan; Ni, Yanli; Li, Zhuan; Xu, Huiyu; Hao, Sha; Wang, Xiaochen; Ma, Shihui; Wang, Qian-fei; Xiao, Guozhi; Yuan, Weiping; Liu, Bing; Cheng, Tao

    2015-11-19

    The fetal liver (FL) serves as a predominant site for expansion of functional hematopoietic stem cells (HSCs) during mouse embryogenesis. However, the mechanisms for HSC development in FL remain poorly understood. In this study, we demonstrate that deletion of activating transcription factor 4 (ATF4) significantly impaired hematopoietic development and reduced HSC self-renewal in FL. In contrast, generation of the first HSC population in the aorta-gonad-mesonephros region was not affected. The migration activity of ATF4(-/-) HSCs was moderately reduced. Interestingly, the HSC-supporting ability of both endothelial and stromal cells in FL was significantly compromised in the absence of ATF4. Gene profiling using RNA-seq revealed downregulated expression of a panel of cytokines in ATF4(-/-) stromal cells, including angiopoietin-like protein 3 (Angptl3) and vascular endothelial growth factor A (VEGFA). Addition of Angptl3, but not VEGFA, partially rescued the repopulating defect of ATF4(-/-) HSCs in the culture. Furthermore, chromatin immunoprecipitation assay in conjunction with silencing RNA-mediated silencing and complementary DNA overexpression showed transcriptional control of Angptl3 by ATF4. To summarize, ATF4 plays a pivotal role in functional expansion and repopulating efficiency of HSCs in developing FL, and it acts through upregulating transcription of cytokines such as Angptl3 in the microenvironment.

  17. C/EBPγ Is a Critical Regulator of Cellular Stress Response Networks through Heterodimerization with ATF4.

    Science.gov (United States)

    Huggins, Christopher J; Mayekar, Manasi K; Martin, Nancy; Saylor, Karen L; Gonit, Mesfin; Jailwala, Parthav; Kasoji, Manjula; Haines, Diana C; Quiñones, Octavio A; Johnson, Peter F

    2015-12-14

    The integrated stress response (ISR) controls cellular adaptations to nutrient deprivation, redox imbalances, and endoplasmic reticulum (ER) stress. ISR genes are upregulated in stressed cells, primarily by the bZIP transcription factor ATF4 through its recruitment to cis-regulatory C/EBP:ATF response elements (CAREs) together with a dimeric partner of uncertain identity. Here, we show that C/EBPγ:ATF4 heterodimers, but not C/EBPβ:ATF4 dimers, are the predominant CARE-binding species in stressed cells. C/EBPγ and ATF4 associate with genomic CAREs in a mutually dependent manner and coregulate many ISR genes. In contrast, the C/EBP family members C/EBPβ and C/EBP homologous protein (CHOP) were largely dispensable for induction of stress genes. Cebpg(-/-) mouse embryonic fibroblasts (MEFs) proliferate poorly and exhibit oxidative stress due to reduced glutathione levels and impaired expression of several glutathione biosynthesis pathway genes. Cebpg(-/-) mice (C57BL/6 background) display reduced body size and microphthalmia, similar to ATF4-null animals. In addition, C/EBPγ-deficient newborns die from atelectasis and respiratory failure, which can be mitigated by in utero exposure to the antioxidant, N-acetyl-cysteine. Cebpg(-/-) mice on a mixed strain background showed improved viability but, upon aging, developed significantly fewer malignant solid tumors than WT animals. Our findings identify C/EBPγ as a novel antioxidant regulator and an obligatory ATF4 partner that controls redox homeostasis in normal and cancerous cells.

  18. Murine cytomegalovirus targets transcription factor ATF4 to exploit the unfolded-protein response.

    Science.gov (United States)

    Qian, Zhikang; Xuan, Baoqin; Chapa, Travis J; Gualberto, Nathaniel; Yu, Dong

    2012-06-01

    The unfolded-protein response (UPR), activated by sensor molecules PERK, ATF6, and IRE1 to resolve endoplasmic reticulum (ER) stress, has emerged as a key target for host cells and viruses to control the infection outcomes. The UPR regulates ER protein folding, controls cell fate upon ER stress, and plays an important role in innate immunity. We and others have shown that human cytomegalovirus (HCMV) modulates the UPR. We show here that murine CMV (MCMV), the widely used CMV model for small animal infection, regulated the UPR in a manner similar to that of HCMV. This modulatory ability was triggered by virion entry and enhanced by viral immediate-early and early gene expression. Thus, while vulnerable at early times, MCMV became resistant to exogenous ER stress at late times of infection. MCMV activated the PERK-ATF4 pathway but only induced a subset of representative ATF4 targets at levels somewhat lower than those by the ER stress inducer tunicamycin. Moreover, MCMV induced ER chaperone Bip but actively blocked IRE1-mediated Xbp1(s) protein accumulation. ATF4 depletion severely attenuated viral growth at a low multiplicity of infection by modestly reducing viral DNA synthesis and more pronouncedly inhibiting late gene transcription. Collectively, we show that the UPR is a conserved target of CMVs and identify ATF4, a key UPR component, as a factor critical for MCMV infection. This work sets the stage for using the MCMV model to explore the role of this stress response in CMV biology, particularly during infection of the host, which is difficult to study in HCMV.

  19. Gaseous toroid around Saturn. [Saturnian ring system for atomic hydrogen trapping in Titan atmospheric model

    Science.gov (United States)

    Mcdonough, T. R.

    1974-01-01

    The trapping of Titan's escaping atmosphere in the Saturnian system by a toroidal ring is discussed. The radius of the toroid is comparable to Titan's orbit, or about ten times larger than the visible rings. Theoretical atmospheric models are formulated that consider Saturn's gravitational attraction and magnetospheric properties in forming this toroid and in protecting toroid particles from direct ionization by solar wind particles.

  20. ATF7IP-Mediated Stabilization of the Histone Methyltransferase SETDB1 Is Essential for Heterochromatin Formation by the HUSH Complex

    Directory of Open Access Journals (Sweden)

    Richard T. Timms

    2016-10-01

    Full Text Available The histone methyltransferase SETDB1 plays a central role in repressive chromatin processes, but the functional requirement for its binding partner ATF7IP has remained enigmatic. Here, we show that ATF7IP is essential for SETDB1 stability: nuclear SETDB1 protein is degraded by the proteasome upon ablation of ATF7IP. As a result, ATF7IP is critical for repression that requires H3K9 trimethylation by SETDB1, including transgene silencing by the HUSH complex. Furthermore, we show that loss of ATF7IP phenocopies loss of SETDB1 in genome-wide assays. ATF7IP and SETDB1 knockout cells exhibit near-identical defects in the global deposition of H3K9me3, which results in similar dysregulation of the transcriptome. Overall, these data identify a critical functional role for ATF7IP in heterochromatin formation by regulating SETDB1 abundance in the nucleus.

  1. ATF7IP-Mediated Stabilization of the Histone Methyltransferase SETDB1 Is Essential for Heterochromatin Formation by the HUSH Complex.

    Science.gov (United States)

    Timms, Richard T; Tchasovnikarova, Iva A; Antrobus, Robin; Dougan, Gordon; Lehner, Paul J

    2016-10-11

    The histone methyltransferase SETDB1 plays a central role in repressive chromatin processes, but the functional requirement for its binding partner ATF7IP has remained enigmatic. Here, we show that ATF7IP is essential for SETDB1 stability: nuclear SETDB1 protein is degraded by the proteasome upon ablation of ATF7IP. As a result, ATF7IP is critical for repression that requires H3K9 trimethylation by SETDB1, including transgene silencing by the HUSH complex. Furthermore, we show that loss of ATF7IP phenocopies loss of SETDB1 in genome-wide assays. ATF7IP and SETDB1 knockout cells exhibit near-identical defects in the global deposition of H3K9me3, which results in similar dysregulation of the transcriptome. Overall, these data identify a critical functional role for ATF7IP in heterochromatin formation by regulating SETDB1 abundance in the nucleus.

  2. ATF3 upregulation in glia during Wallerian degeneration: differential expression in peripheral nerves and CNS white matter

    Directory of Open Access Journals (Sweden)

    Coffin Robert S

    2004-03-01

    Full Text Available Abstract Background Many changes in gene expression occur in distal stumps of injured nerves but the transcriptional control of these events is poorly understood. We have examined the expression of the transcription factors ATF3 and c-Jun by non-neuronal cells during Wallerian degeneration following injury to sciatic nerves, dorsal roots and optic nerves of rats and mice, using immunohistochemistry and in situ hybridization. Results Following sciatic nerve injury – transection or transection and reanastomosis – ATF3 was strongly upregulated by endoneurial, but not perineurial cells, of the distal stumps of the nerves by 1 day post operation (dpo and remained strongly expressed in the endoneurium at 30 dpo when axonal regeneration was prevented. Most ATF3+ cells were immunoreactive for the Schwann cell marker, S100. When the nerve was transected and reanastomosed, allowing regeneration of axons, most ATF3 expression had been downregulated by 30 dpo. ATF3 expression was weaker in the proximal stumps of the injured nerves than in the distal stumps and present in fewer cells at all times after injury. ATF3 was upregulated by endoneurial cells in the distal stumps of injured neonatal rat sciatic nerves, but more weakly than in adult animals. ATF3 expression in transected sciatic nerves of mice was similar to that in rats. Following dorsal root injury in adult rats, ATF3 was upregulated in the part of the root between the lesion and the spinal cord (containing Schwann cells, beginning at 1 dpo, but not in the dorsal root entry zone or in the degenerating dorsal column of the spinal cord. Following optic nerve crush in adult rats, ATF3 was found in some cells at the injury site and small numbers of cells within the optic nerve displayed weak immunoreactivity. The pattern of expression of c-Jun in all types of nerve injury was similar to that of ATF3. Conclusion These findings raise the possibility that ATF3/c-Jun heterodimers may play a role in

  3. Toroidicity Dependence of Tokamak Edge Safety Factor and Shear

    Institute of Scientific and Technical Information of China (English)

    SHIBingren

    2002-01-01

    In large tokamak device and reactor designs, the relationship between the toroidal current and the edge safety factor is very important because this will determine the eventual device or reactor size according to MHD stability requirements. In many preliminary

  4. Influence of toroidal rotation on resistive tearing modes in tokamaks

    Energy Technology Data Exchange (ETDEWEB)

    Wang, S.; Ma, Z. W., E-mail: zwma@zju.edu.cn [Institute for Fusion Theory and Simulation, Zhejiang University, Hangzhou 310027 (China)

    2015-12-15

    Influence of toroidal equilibrium plasma rotation on m/n = 2/1 resistive tearing modes is studied numerically using a 3D toroidal MHD code (CLT). It is found that the toroidal rotation with or without shear can suppress the tearing instability and the Coriolis effect in the toroidal geometry plays a dominant role on the rotation induced stabilization. For a high viscosity plasma (τ{sub R}/τ{sub V} ≫ 1, where τ{sub R} and τ{sub V} represent resistive and viscous diffusion time, respectively), the effect of the rotation shear combined with the viscosity appears to be stabilizing. For a low viscosity plasmas (τ{sub R}/τ{sub V} ≪ 1), the rotation shear shows a destabilizing effect when the rotation is large.

  5. Influence of toroidal rotation on resistive tearing modes in tokamaks

    Science.gov (United States)

    Wang, S.; Ma, Z. W.

    2015-12-01

    Influence of toroidal equilibrium plasma rotation on m/n = 2/1 resistive tearing modes is studied numerically using a 3D toroidal MHD code (CLT). It is found that the toroidal rotation with or without shear can suppress the tearing instability and the Coriolis effect in the toroidal geometry plays a dominant role on the rotation induced stabilization. For a high viscosity plasma (τR/τV ≫ 1, where τR and τV represent resistive and viscous diffusion time, respectively), the effect of the rotation shear combined with the viscosity appears to be stabilizing. For a low viscosity plasmas (τR/τV ≪ 1), the rotation shear shows a destabilizing effect when the rotation is large.

  6. 3D blob dynamics in toroidal geometry

    DEFF Research Database (Denmark)

    Nielsen, Anders Henry; Reiser, Dirk

    . The DIESEL code is an extension of the ESEL code [1]. It solves a simple interchange model in full 3D tokamak geometry, where the toroidal direction is divided into a number of drift planes. On each drift plane the equations are solved in a domain corresponding to the full 2D cross section of the tokamak......In this paper we study the simple case of the dynamics of a density perturbation localized in the edge region of a medium sized tokamak in a full 3D geometry. The 2D evolution of such a perturbation has been studied in details on the low-field side, where the gradient of the magnetic field always...... point radial inward, see e.g. [1-2]. Here, the initial condition is implemented in two very different 3D numerical codes, ATTEMPT [3], and a new developed code, DIESEL (Disk version of ESEL), and the results are compared and discussed in detail. The ATTEMPT code has been employed to study the blob...

  7. Sawtooth Instability in the Compact Toroidal Hybrid

    Science.gov (United States)

    Herfindal, J. L.; Maurer, D. A.; Hartwell, G. J.; Ennis, D. A.; Knowlton, S. F.

    2015-11-01

    Sawtooth instabilities have been observed in the Compact Toroidal Hybrid (CTH), a current-carrying stellarator/tokamak hybrid device. The sawtooth instability is driven by ohmic heating of the core plasma until the safety factor drops below unity resulting in the growth of an m = 1 kink-tearing mode. Experiments varying the vacuum rotational transform from 0.02 to 0.13 are being conducted to study sawtooth property dependance on vacuum flux surface structure. The frequency of the sawtooth oscillations increase from 2 kHz to 2.8 kHz solely due the decrease in rise time of the oscillation, the crash time is unchanged. CTH has three two-color SXR cameras, a three-channel 1mm interferometer, and a new bolometer system capable of detecting the signatures of sawtooth instabilities. The new bolometer system consists of two cameras, each containing a pair of diode arrays viewing the plasma directly or through a beryllium filter. Electron temperature measurements are found with the two-color SXR cameras through a ratio of the SXR intensities. Impurity radiation can drastically affect the electron temperature measurement, therefore new filters consisting of aluminum and carbon were selected to avoid problematic line radiation while maximizing the signal for a 100 eV plasma. This work is supported by U.S. Department of Energy Grant No. DE-FG02-00ER54610.

  8. Ballooning mode spectrum in general toroidal systems

    Energy Technology Data Exchange (ETDEWEB)

    Dewar, R.L.; Glasser, A.H.

    1982-04-01

    A WKB formalism for constructing normal modes of short-wavelength ideal hydromagnetic, pressure-driven instabilities (ballooning modes) in general toroidal magnetic containment devices with sheared magnetic fields is developed. No incompressibility approximation is made. A dispersion relation is obtained from the eigenvalues of a fourth order system of ordinary differential equations to be solved by integrating along a line of force. Higher order calculations are performed to find the amplitude equation and the phase change at a caustic. These conform to typical WKB results. In axisymmetric systems, the ray equations are integrable, and semiclassical quantization leads to a growth rate spectrum consisting of an infinity of discrete eigenvalues, bounded above by an accumulation point. However, each eigenvalue is infinitely degenerate. In the nonaxisymmetric case, the rays are unbounded in a four dimensional phase space, and semiclassical quantization breaks down, leading to broadening of the discrete eigenvalues and accumulation point of the axisymmetric case into continuum bands. Analysis of a model problem indicates that the broadening of the discrete eigenvalues is numerically very small, the dominant effect being broadening of the accumulation point.

  9. Turbulent Equipartition Theory of Toroidal Momentum Pinch

    Energy Technology Data Exchange (ETDEWEB)

    T.S. Hahm, P.H. Diamond, O.D. Gurcan, and G. Rewaldt

    2008-01-31

    The mode-independet part of magnetic curvature driven turbulent convective (TuroCo) pinch of the angular momentum density [Hahm et al., Phys. Plasmas 14,072302 (2007)] which was originally derived from the gyrokinetic equation, can be interpreted in terms of the turbulent equipartition (TEP) theory. It is shown that the previous results can be obtained from the local conservation of "magnetically weighted angular momentum density," nmi U|| R/B2, and its homogenization due to turbulent flows. It is also demonstrated that the magnetic curvature modification of the parallel acceleration in the nonlinear gyrokinetic equation in the laboratory frame, which was shown to be responsible for the TEP part of the TurCo pinch of angular momentum density in the previous work, is closely related to the Coriolis drift coupling to the perturbed electric field. In addition, the origin of the diffusive flux in the rotating frame is highlighted. Finally, it is illustratd that there should be a difference in scalings between the momentum pinch originated from inherently toroidal effects and that coming from other mechanisms which exist in a simpler geometry.

  10. Electric disruption in a hydrogen toroidal plasma; Ruptura eletrica em um plasma toroidal em hidrogenio

    Energy Technology Data Exchange (ETDEWEB)

    Roberto, M. [UNESP, Guaratingueta, SP (Brazil). Faculdade de Engenharia. Dept. de Fisica; Silva, C.A.B. [Centro Tecnico Aeroespacial (CTA-IEAv), Sao Jose dos Campos, SP (Brazil). Inst. de Estudos Avancados; Goes, L.C.S.; Sudano, J.P. [Centro Tecnico Aeroespacial, Sao Jose dos Campos, SP (Brazil). Inst. Tecnologico de Aeronautica

    1990-12-31

    By using a zero-dimensional model the ionizing initial phase of a toroidal plasma produced in hydrogen was investigated. The model consists on describing the plasma time evolution through the density and particle temperature space averaged on the plasma volume. The involved equations are energy and particles balance equations (electrons and ions). The electron loss is due to ambipolar diffusion in the presence of magnetic field. The electron energy loss is due to ionizing, processes of Coulomb interaction and diffusion. The ohmic heating transformer gives a initial voltage necessary to the breaking 11 refs., 2 figs.

  11. An important step for the ATLAS toroid magnet

    CERN Multimedia

    2000-01-01

    The ATLAS experiment's prototype toroid coil arrives at CERN from the CEA laboratory in Saclay on 6 October. The world's largest superconducting toroid magnet is under construction for the ATLAS experiment. A nine-metre long fully functional prototype coil was delivered to CERN at the beginning of October and has since been undergoing tests in the West Area. Built mainly by companies in France and Italy under the supervision of engineers from the CEA-Saclay laboratory near Paris and Italy's INFN-LASA, the magnet is a crucial step forward in the construction of the ATLAS superconducting magnet system. Unlike any particle detector that has gone before, the ATLAS detector's magnet system consists of a large toroidal system enclosing a small central solenoid. The barrel part of the toroidal system will use eight toroid coils, each a massive 25 metres in length. These will dwarf the largest toroids in the world when ATLAS was designed, which measure about six metres. So the ATLAS collaboration decided to build a...

  12. Real-time volumetric visualization of high-resolution array and toroidal volume search sonar data

    Science.gov (United States)

    Cross, Robert A.

    1998-09-01

    The Advanced Volume Visualization Display (AVVD) research program is a joint research program between the Fraunhofer Center for Research in Computer Graphics, Inc. and Innovative Research and Development Corp. It is dedicated the application of the human visual system to real-time visualization of high- resolution volumetric sensor data sets. The AVVD program has successfully demonstrated its application to undersea imaging using data from the Naval Undersea Warfare Center -- Division Newport's High Resolution Array (HRA), and from the Naval Surface Warfare Center -- Coastal System Stations's Toroidal Volume Search Sonar (TVSS).

  13. Toroidal momentum pinch velocity due to the coriolis drift effect on small scale instabilities in a toroidal plasma.

    Science.gov (United States)

    Peeters, A G; Angioni, C; Strintzi, D

    2007-06-29

    In this Letter, the influence of the "Coriolis drift" on small scale instabilities in toroidal plasmas is shown to generate a toroidal momentum pinch velocity. Such a pinch results because the Coriolis drift generates a coupling between the density and temperature perturbations on the one hand and the perturbed parallel flow velocity on the other. A simple fluid model is used to highlight the physics mechanism and gyro-kinetic calculations are performed to accurately assess the magnitude of the pinch. The derived pinch velocity leads to a radial gradient of the toroidal velocity profile even in the absence of a torque on the plasma and is predicted to generate a peaking of the toroidal velocity profile similar to the peaking of the density profile. Finally, the pinch also affects the interpretation of current experiments.

  14. Operational Experiences Tuning the ATF2 Final Focus Optics Towards Obtaining a 37nm Electron Beam IP Spot Size

    CERN Document Server

    White, Glen; Woodley, Mark; Bai, Sha; Bambade, Philip; Renier, Yves; Bolzon, Benoit; Kamiya, Yoshio; Komamiya, Sachio; Oroku, Masahiro; Yamaguchi, Yohei; Yamanaka, Takashi; Kubo, Kiyoshi; Kuroda, Shigeru; Okugi, Toshiyuki; Tauchi, Toshiaki; Marin, Eduardo

    2010-01-01

    The primary aim of the ATF2 research accelerator is to test a scaled version of the final focus optics planned for use in next-generation linear lepton colliders. ATF2 consists of a 1.3 GeV linac, damping ring providing lowemittance electron beams (<12pm in the vertical plane), extraction line and final focus optics. The design details of the final focus optics and implementation at ATF2 are presented elsewhere. The ATF2 accelerator is currently being commissioned, with a staged approach to achieving the design IP spot size. It is expected that as we implement more demanding optics and reduce the vertical beta function at the IP, the tuning becomes more difficult and takes longer. We present here a description of the implementation of the tuning procedures and describe operational experiences and performances

  15. Lipopolysaccharide preconditioning protects hepatocytes from ischemia/reperfusion injury (IRI through inhibiting ATF4-CHOP pathway in mice.

    Directory of Open Access Journals (Sweden)

    Jianhua Rao

    Full Text Available BACKGROUND: Low-dose lipopolysaccharide (LPS preconditioning-induced liver protection has been demonstrated during ischemia-reperfusion injury (IRI in several organs but has not been sufficiently elucidated underlying causal mechanism. This study investigated the role of low-dose LPS preconditioning on ATF4-CHOP pathway as well as the effects of the pathway on tissue injury and inflammation in a mouse model of liver partial-warm IRI. METHODS: LPS (100 µg/kg/d was injected intraperitoneally two days before ischemia. Hepatic injury was evaluated based on serum alanine aminotransferase levels, histopathology, and caspase-3 activity. The ATF4-CHOP pathway and its related apoptotic molecules were investigated after reperfusion. The role of LPS preconditioning on apoptosis and ATF4-CHOP pathway was examined in vitro. Moreover, the effects of the ATF4-CHOP pathway on apoptosis, Caspase-12, and Caspase-3 were determined with ATF4 small interfering RNA (siRNA. Inflammatory cytokine expression was also checked after reperfusion. Inflammatory cytokines and related signaling pathways were analyzed in vitro in macrophages treated by LPS preconditioning or ATF4 siRNA. RESULTS: LPS preconditioning significantly attenuated liver injury after IRI. As demonstrated by in vitro experiments, LPS preconditioning significantly reduced the upregulation of the ATF4-CHOP pathway and inhibited Caspase-12 and Caspase-3 activation after IRI. Later experiments showed that ATF4 knockdown significantly suppressed CHOP, cleaved caspase-12 and caspase-3 expression, as well as inhibited hepatocellular apoptosis. In addition, in mice pretreated with LPS, TNF-α and IL-6 were inhibited after reperfusion, whereas IL-10 was upregulated. Similarly, low-dose LPS significantly inhibited TNF-α, IL-6, ATF4-CHOP pathway, NF-κB pathway, and ERK1/2 in high-dose LPS-stimulated macrophages, whereas IL-10 and cytokine signaling (SOCS-3 suppressor were induced. Importantly, ATF4 siRNA is

  16. Nutrient shortage triggers the hexosamine biosynthetic pathway via the GCN2-ATF4 signalling pathway.

    Science.gov (United States)

    Chaveroux, Cédric; Sarcinelli, Carmen; Barbet, Virginie; Belfeki, Sofiane; Barthelaix, Audrey; Ferraro-Peyret, Carole; Lebecque, Serge; Renno, Toufic; Bruhat, Alain; Fafournoux, Pierre; Manié, Serge N

    2016-06-03

    The hexosamine biosynthetic pathway (HBP) is a nutrient-sensing metabolic pathway that produces the activated amino sugar UDP-N-acetylglucosamine, a critical substrate for protein glycosylation. Despite its biological significance, little is known about the regulation of HBP flux during nutrient limitation. Here, we report that amino acid or glucose shortage increase GFAT1 production, the first and rate-limiting enzyme of the HBP. GFAT1 is a transcriptional target of the activating transcription factor 4 (ATF4) induced by the GCN2-eIF2α signalling pathway. The increased production of GFAT1 stimulates HBP flux and results in an increase in O-linked β-N-acetylglucosamine protein modifications. Taken together, these findings demonstrate that ATF4 provides a link between nutritional stress and the HBP for the regulation of the O-GlcNAcylation-dependent cellular signalling.

  17. Parameters Optimization for a Novel Vacuum Laser Acceleration Test at BNL-ATF

    CERN Document Server

    Shao, Lei; Zhou, Feng

    2005-01-01

    This paper presents a new VLA theory model which has revealed that the injection electrons with low energy and small incident angle relative to the laser beam are captured and significantly accelerated in a strong laser field. For the further step for verifying the novel-VLA mechanics, we propose to use the BNL-ATF Terawatt CO2 laser and a high-brightness electron beam to carry out a proof-of-principle beam experiment. Experiment setup including the laser injection optics and electron extraction system and beam diagnostics is presented. Extensive optimized simulation results with ATF practical parameters are also presented, which shows that even when the laser intensity is not very high, the net energy gain still can be seen obviously. This could be prospect for a new revolution of vacuum laser acceleration.

  18. Transcription Factor ATF4 Induces NLRP1 Inflammasome Expression during Endoplasmic Reticulum Stress.

    Directory of Open Access Journals (Sweden)

    Andrea D'Osualdo

    Full Text Available Perturbation of endoplasmic reticulum (ER homeostasis triggers the ER stress response (also known as Unfolded Protein Response, a hallmark of many pathological disorders. However the connection between ER stress and inflammation remains largely unexplored. Recent data suggest that ER stress controls the activity of inflammasomes, key signaling platforms that mediate innate immune responses. Here we report that expression of NLRP1, a core inflammasome component, is specifically up-regulated during severe ER stress conditions in human cell lines. Both IRE1α and PERK, but not the ATF6 pathway, modulate NLRP1 gene expression. Furthermore, using mutagenesis, chromatin immunoprecipitation and CRISPR-Cas9-mediated genome editing technology, we demonstrate that ATF4 transcription factor directly binds to NLRP1 promoter during ER stress. Although involved in different types of inflammatory responses, XBP-1 splicing was not required for NLRP1 induction. This study provides further evidence that links ER stress with innate.

  19. Beam-based alignment at the KEK-ATF damping ring

    Energy Technology Data Exchange (ETDEWEB)

    Woodley, Mark D.; Nelson, Janice; Ross, Marc; Turner, James; Wolski, A.; Kubo, Kiyoshi

    2004-06-30

    The damping rings of a future linear collider will have demanding alignment and stability requirements in order to achieve the low vertical emittance necessary for high luminosity. The Accelerator Test Facility (ATF) at KEK has successfully demonstrated the vertical emittance below 5 pm that is specified for the GLC/NLC Main Damping Rings. One contribution to this accomplishment has been the use of Beam Based Alignment (BBA) techniques. The mode of operation of the ATF presents particular challenges for BBA, and we describe here how we have deduced the offsets of the BPMs with respect to the quadrupoles. We also discuss a technique that allows for direct measurements of the beam-to-quad offsets.

  20. Performance Comparison of Different System Identification Algorithms for FACET and ATF2

    CERN Document Server

    Pfingstner, J; Schulte, D

    2013-01-01

    Good system knowledge is an essential ingredient for the operation of modern accelerator facilities. For example, beam-based alignment algorithms and orbit feedbacks rely strongly on a precise measurement of the orbit response matrix. The quality of the measurement of this matrix can be improved over time by statistically combining the effects of small system excitations with the help of system identification algorithms. These small excitations can be applied in a parasitic mode without stopping the accelerator operation (on-line). In this work, different system identification algorithms are used in simulation studies for the response matrix measurement at ATF2. The results for ATF2 are finally compared with the results for FACET, latter originating from an earlier work.

  1. 4D Emittance Measurements Using Multiple Wire and Waist Scan Methods in the ATF Extraction Line

    Energy Technology Data Exchange (ETDEWEB)

    Rimbault, C.; Bambade, P.; Brossard, J.; /Orsay, LAL; Alabau, M.; /Valencia U., IFIC; Kuroda, S.; /KEK, Tsukuba; Scarfe, A.; /Manchester U.; Woodley, M.; /SLAC

    2011-11-02

    Emittance measurements performed in the diagnostic section of the Accelerator Test Facility (ATF) extraction line since 1998 led to vertical emittances three times larger than the expected ones, with a strong dependence on intensity. An experimental program is pursued to investigate potential sources of emittance growth and find possible remedies. This requires efficient and reliable emittance measurement techniques. In the past, several phase-space reconstruction methods developed at SLAC and KEK have been used to estimate the vertical emittance, based on multiple location beam size measurements and dedicated quadrupole scans. These methods have been shown to be very sensitive to measurement errors and other fluctuations in the beam conditions. In this context new emittance measurements have been performed revisiting these methods and newly developed ones with a systematic approach to compare and characterise their performance in the ATF extraction line.

  2. Signaling dynamics of palmitate-induced ER stress responses mediated by ATF4 in HepG2 cells

    Directory of Open Access Journals (Sweden)

    Cho Hyunju

    2013-01-01

    Full Text Available Abstract Background Palmitic acid, the most common saturated free fatty acid, has been implicated in ER (endoplasmic reticulum stress-mediated apoptosis. This lipoapotosis is dependent, in part, on the upregulation of the activating transcription factor-4 (ATF4. To better understand the mechanisms by which palmitate upregulates the expression level of ATF4, we integrated literature information on palmitate-induced ER stress signaling into a discrete dynamic model. The model provides an in silico framework that enables simulations and predictions. The model predictions were confirmed through further experiments in human hepatocellular carcinoma (HepG2 cells and the results were used to update the model and our current understanding of the signaling induced by palmitate. Results The three key things from the in silico simulation and experimental results are: 1 palmitate induces different signaling pathways (PKR (double-stranded RNA-activated protein kinase, PERK (PKR-like ER kinase, PKA (cyclic AMP (cAMP-dependent protein kinase A in a time dependent-manner, 2 both ATF4 and CREB1 (cAMP-responsive element-binding protein 1 interact with the Atf4 promoter to contribute to a prolonged accumulation of ATF4, and 3 CREB1 is involved in ER-stress induced apoptosis upon palmitate treatment, by regulating ATF4 expression and possibly Ca2+ dependent-CaM (calmodulin signaling pathway. Conclusion The in silico model helped to delineate the essential signaling pathways in palmitate-mediated apoptosis.

  3. ATF3 is a novel nuclear marker for migrating ependymal stem cells in the rat spinal cord.

    Science.gov (United States)

    Mladinic, Miranda; Bianchetti, Elena; Dekanic, Ana; Mazzone, Graciela L; Nistri, Andrea

    2014-05-01

    The present study identified ATF3 as a novel dynamic marker for ependymal stem/progenitor cells (nestin, vimentin and SOX2 positive) around the central canal of the neonatal or adult rat spinal cord. While quiescent ependymal cells showed cytoplasmic ATF3 expression, during 6-24h in vitro these cells mobilized and acquired intense nuclear ATF3 staining. Their migratory pattern followed a centrifugal pathway toward the dorsal and ventral funiculi, reminiscent of the rostral migratory stream of the brain subventricular stem cells. Thus, the chain cell formation was, by analogy, termed funicular migratory stream (FMS). The FMS process preceded the strong proliferation of ependymal cells occurring only after 24h in vitro. Pharmacological inhibition of MAPK-p38 and JNK/c-Jun (upstream effectors of ATF3 activation) prevented the FMS mobilization of ATF3 nuclear-positive cells. Excitotoxicity or ischemia-like conditions, reported to evoke neuronal and glial injury, did not further enhance migration of ependymal cells at 24h, suggesting that, at this early stage of damage, the FMS phenomenon had peaked and that more extensive repair processes are delayed beyond this time point. ATF3 is, therefore, useful to identify activation and migration of endogenous stem cells of the rat spinal cord in vitro.

  4. ATF4- and CHOP-Dependent Induction of FGF21 through Endoplasmic Reticulum Stress

    Directory of Open Access Journals (Sweden)

    Xiao-shan Wan

    2014-01-01

    Full Text Available Fibroblast growth factor 21 (FGF21 is an important endogenous regulator involved in the regulation of glucose and lipid metabolism. FGF21 expression is strongly induced in animal and human subjects with metabolic diseases, but little is known about the molecular mechanism. Endoplasmic reticulum (ER stress plays an essential role in metabolic homeostasis and is observed in numerous pathological processes, including type 2 diabetes, overweight, nonalcoholic fatty liver disease (NAFLD. In this study, we investigate the correlation between the expression of FGF21 and ER stress. We demonstrated that TG-induced ER stress directly regulated the expression and secretion of FGF21 in a dose- and time-dependent manner. FGF21 is the target gene for activating transcription factor 4 (ATF4 and CCAAT enhancer binding protein homologous protein (CHOP. Suppression of CHOP impaired the transcriptional activation of FGF21 by TG-induced ER stress in CHOP−/− mouse primary hepatocytes (MPH, and overexpression of ATF4 and CHOP resulted in FGF21 promoter activation to initiate the transcriptional programme. In mRNA stability assay, we indicated that ER stress increased the half-life of mRNA of FGF21 significantly. In conclusion, FGF21 expression is regulated by ER stress via ATF- and CHOP-dependent transcriptional mechanism and posttranscriptional mechanism, respectively.

  5. Profiling compact toroid plasma density on CTIX with laser deflection

    Science.gov (United States)

    Brockington, Samuel Joseph Erwin

    A laser deflectometer measures line-integrated plasma density gradient using laser diodes and amplified point detectors. A laser passing through an optically thin plasma is refracted by an amount proportional to the line-integrated electron density gradient. I have designed, installed, and operated a deflection diagnostic for the Compact Toroid Injection Experiment (CTIX), a plasma rail gun which can create compact toroid (CT) plasmas of controllable density and velocity. The diagnostic design and motivation are discussed, as well as three experiments performed with deflectometry. Thus, my thesis consists of the design of the deflectometer diagnostic, a comparison of its accuracy to interferometer density measurements, and finally a survey of compact toroid density profiles in two dimensions conducted with an array of detectors.

  6. Ultra-high-Q toroidal microresonators for cavity quantum electrodynamics

    CERN Document Server

    Spillane, S M; Vahala, K J; Goh, K W; Wilcut, E; Kimble, H J

    2004-01-01

    We investigate the suitability of toroidal microcavities for strong-coupling cavity quantum electrodynamics (QED). Numerical modeling of the optical modes demonstrate a significant reduction of modal volume with respect to the whispering gallery modes of dielectric spheres, while retaining the high quality factors representative of spherical cavities. The extra degree of freedom of toroid microcavities can be used to achieve improved cavity QED characteristics. Numerical results for atom-cavity coupling strength, critical atom number N_0 and critical photon number n_0 for cesium are calculated and shown to exceed values currently possible using Fabry-Perot cavities. Modeling predicts coupling rates g/(2*pi) exceeding 700 MHz and critical atom numbers approaching 10^{-7} in optimized structures. Furthermore, preliminary experimental measurements of toroidal cavities at a wavelength of 852 nm indicate that quality factors in excess of 100 million can be obtained in a 50 micron principal diameter cavity, which w...

  7. Stellar Dynamo Models with Prominent Surface Toroidal Fields

    Science.gov (United States)

    Bonanno, Alfio

    2016-12-01

    Recent spectro-polarimetric observations of solar-type stars have shown the presence of photospheric magnetic fields with a predominant toroidal component. If the external field is assumed to be current-free it is impossible to explain these observations within the framework of standard mean-field dynamo theory. In this work, it will be shown that if the coronal field of these stars is assumed to be harmonic, the underlying stellar dynamo mechanism can support photospheric magnetic fields with a prominent toroidal component even in the presence of axisymmetric magnetic topologies. In particular, it is argued that the observed increase in the toroidal energy in low-mass fast-rotating stars can be naturally explained with an underlying αΩ mechanism.

  8. Stellar dynamo models with prominent surface toroidal fields

    CERN Document Server

    Bonanno, Alfio

    2016-01-01

    Recent spectro-polarimetric observations of solar-type stars have shown the presence of photospheric magnetic fields with a predominant toroidal component. If the external field is assumed to be current-free it is impossible to explain these observations within the framework of standard mean-field dynamo theory. In this work it will be shown that if the coronal field of these stars is assumed to be harmonic, the underlying stellar dynamo mechanism can support photospheric magnetic fields with a prominent toroidal component even in the presence of axisymmetric magnetic topologies. In particular it is argued that the observed increase in the toroidal energy in low mass fast rotating stars can be naturally explained with an underlying $\\alpha\\Omega$ mechanism.

  9. Compact Toroid Propagation in a Magnetized Drift Tube

    Science.gov (United States)

    Horton, Robert D.; Baker, Kevin L.; Hwang, David Q.; Evans, Russell W.

    2000-10-01

    Injection of a spheromak-like compact toroid (SCT) plasma into a toroidal plasma confinement device may require the SCT to propagate through a drift tube region occupied by a pre-existing magnetic field. This field is expected to extert a retarding force on the SCT, but may also result in a beneficial compression. The effects of transverse and longitudinal magnetic fields will be measured using the CTIX compact-toroid injector, together with a fast framing camera with an axial view of the formation, coaxial, and drift-tube regions. In the case of longitudinal magnetic field, comparisons will be made with the predictions of two-dimensional numerical simulation. The use of localized magnetic field to reduce plasma bridging of the insulating gap will also be investigated.

  10. Vlasov tokamak equilibria with shearad toroidal flow and anisotropic pressure

    CERN Document Server

    Kuiroukidis, Ap; Tasso, H

    2015-01-01

    By choosing appropriate deformed Maxwellian ion and electron distribution functions depending on the two particle constants of motion, i.e. the energy and toroidal angular momentum, we reduce the Vlasov axisymmetric equilibrium problem for quasineutral plasmas to a transcendental Grad-Shafranov-like equation. This equation is then solved numerically under the Dirichlet boundary condition for an analytically prescribed boundary possessing a lower X-point to construct tokamak equilibria with toroidal sheared ion flow and anisotropic pressure. Depending on the deformation of the distribution functions these steady states can have toroidal current densities either peaked on the magnetic axis or hollow. These two kinds of equilibria may be regarded as a bifurcation in connection with symmetry properties of the distribution functions on the magnetic axis.

  11. Efficiency of Wave-Driven Rigid Body Rotation Toroidal Confinement

    CERN Document Server

    Rax, J -M; Fisch, N J

    2016-01-01

    The compensation of vertical drifts in toroidal magnetic fields through a wave-driven poloidal rotation is compared to compensation through the wave driven toroidal current generation to support the classical magnetic rotational transform. The advantages and drawbacks associated with the sustainment of a radial electric field are compared with those associated with the sustainment of a poloidal magnetic field both in terms of energy content and power dissipation. The energy content of a radial electric field is found to be smaller than the energy content of a poloidal magnetic field for a similar set of orbits. The wave driven radial electric field generation efficiency is similarly shown, at least in the limit of large aspect ratio, to be larger than the efficiency of wave-driven toroidal current generation.

  12. Axion Haloscopes with Toroidal Geometry at CAPP/IBS

    CERN Document Server

    Ko, B R

    2016-01-01

    The present state of the art axion haloscope employs a cylindrical resonant cavity in a solenoidal field. We, the Center for Axion and Precision Physics Research (CAPP) of the Institute for Basic Science (IBS) in Korea, are also pursuing halo axion discovery using this cylindrical geometry. However, the presence of end caps of cavities increases challenges as we explore higher frequency regions for the axion at above 2 GHz. To overcome these challenges we exploit a toroidal design of cavity and magnetic field. A toroidal geometry offers several advantages, two of which are a larger volume for a given space and greatly reduced fringe fields which interfere with our preamps, in particular the planned quantum-based devices. We introduce the concept of toroidal axion haloscopes and present ongoing research activities and plans at CAPP/IBS.

  13. Effects and mechanisms of ATF4 on skin cancer cell proliferation%ATF4对皮肤癌细胞增殖的影响及相关机制

    Institute of Scientific and Technical Information of China (English)

    陈娟; 王翼

    2016-01-01

    Objective: To investigate the effects and mechanisms of knockdown/over-expression of ATF4 on the skin cancer cell proliferation.Methods: hTe expression of ATF4 in different types of skin cancer cells was measured by Western blot. Atfer knockdown or over-expression of ATF4 in A431 cells, the proliferation and cell cycle distribution were measured by CCK-8 assay, colony formation assay or lfow cytometry. hTe protein levels of some cell cycle regulators, such as cyclin D1, cyclin E, P21 and p-Rb/Rb were determined by Western blot. Results: ATF4 was highly expressed in all 3 types of skin cancer cells (P<0.05). ATF4 knockdown repressedthe cell cycle entrance into S-phase from G0/G1 phase followed by a lower cell proliferation rate. Over-expression of ATF4 increased A431 cell proliferation and facilitated cell cycle progression (P<0.05). Furthermore, the protein levels of cyclin D1, cyclin E and p-Rb were significantly decreased after ATF4 knockdown, but the expression of P21 was increased. Over-expression of ATF4 increased the protein levels of cyclin D1, cyclin E and p-Rb, but decreased the P21 expression (P<0.05).Conclusion: ATF4 promotes human squamous cell carcinoma, and its potential mechanisms may be related to promotion of cell cycle transition and expression of cell cycle regulators, suggesting that ATF4 may be a potential new target of treating skin cancer.%目的:探讨沉默/过表达ATF4对人皮肤癌细胞增殖的影响及其相关作用机制。方法:Western blot技术检测不同类型皮肤癌细胞中ATF4的蛋白表达水平。构建ATF4沉默/过表达的A431皮肤癌细胞株,采用CCK-8法、克隆形成实验和流式细胞术检测A431细胞增殖能力的变化及细胞周期分布;Western blot技术检测细胞周期调控因子cyclin D1、cyclin E、P21和p-Rb/Rb的蛋白表达水平。结果:ATF4在3种不同类型的皮肤癌细胞中均呈高表达。CCK-8法和克隆形成实验结果显示沉默ATF4的A431细胞存活率和

  14. Functional analysis of atfA gene to stress response in pathogenic thermal dimorphic fungus Penicillium marneffei.

    Science.gov (United States)

    Nimmanee, Panjaphorn; Woo, Patrick C Y; Vanittanakom, Pramote; Youngchim, Sirida; Vanittanakom, Nongnuch

    2014-01-01

    Penicillium marneffei, the pathogenic thermal dimorphic fungus is a causative agent of a fatal systemic disease, penicilliosis marneffei, in immunocompromised patients especially HIV patients. For growth and survival, this fungus has to adapt to environmental stresses outside and inside host cells and this adaptation requires stress signaling pathways and regulation of gene expression under various kinds of stresses. In this report, P. marneffei activating transcription factor (atfA) gene encoding bZip-type transcription factor was characterized. To determine functions of this gene, atfA isogenic mutant strain was constructed using the modified split marker recombination method. The phenotypes and susceptibility to varieties of stresses including osmotic, oxidative, heat, UV, cell wall and cell membrane stresses of the mutant strain were compared with the wild type and the atfA complemented strains. Results demonstrated that the mRNA expression level of P. marneffei atfA gene increased under heat stress at 42°C. The atfA mutant was more sensitive to sodium dodecyl sulphate, amphotericin B and tert-butyl hydroperoxide than the wild type and complemented strains but not hydrogen peroxide, menadione, NaCl, sorbitol, calcofluor white, itraconazole, UV stresses and heat stress at 39°C. In addition, recovery of atfA mutant conidia after mouse and human macrophage infections was significantly decreased compared to those of wild type and complemented strains. These results indicated that the atfA gene was required by P. marneffei under specific stress conditions and might be necessary for fighting against host immune cells during the initiation of infection.

  15. A neonatal encephalopathy with seizures in standard poodle dogs with a missense mutation in the canine ortholog of ATF2.

    Science.gov (United States)

    Chen, Xuhua; Johnson, Gary S; Schnabel, Robert D; Taylor, Jeremy F; Johnson, Gayle C; Parker, Heidi G; Patterson, Edward E; Katz, Martin L; Awano, Tomoyuki; Khan, Shahwanaz; O'Brien, Dennis P

    2008-02-01

    Neonatal encephalopathy with seizures (NEWS) is a previously undescribed autosomal recessive disease of standard poodle puppies. Affected puppies are small and weak at birth. Many die in their first week of life. Those surviving past 1 week develop ataxia, a whole-body tremor, and, by 4 to 6 weeks of age, severe generalized clonic-tonic seizures. None have survived to 7 weeks of age. Cerebella from affected puppies were reduced in size and often contained dysplastic foci consisting of clusters of intermixed granule and Purkinje neurons. We used deoxyribonucleic acid samples from related standard poodles to map the NEWS locus to a 2.87-Mb segment of CFA36, which contains the canine ortholog of ATF2. This gene encodes activating transcription factor 2 (ATF-2), which participates in the cellular responses to a wide variety of stimuli. We amplified and sequenced all coding regions of canine ATF2 from a NEWS-affected puppy and identified a T > G transversion that predicts a methionine-to-arginine missense mutation at amino acid position 51. Methionine-51 lies within a hydrophobic docking site for mitogen-activated protein kinases that activate ATF-2 so the arginine substitution is likely to interfere with ATF-2 activation. All 20 NEWS-affected puppies in the standard poodle family were homozygous for the mutant G allele. The 58 clinically normal family members were either G/T heterozygotes or homozygous for the ancestral T allele. There are no previous reports of spontaneous ATF2 mutations in people or animals; however, atf2-knockout mice have cerebellar lesions that are similar to those in puppies with NEWS.

  16. Transcription factor ATF4 directs basal and stress-induced gene expression in the unfolded protein response and cholesterol metabolism in the liver.

    Science.gov (United States)

    Fusakio, Michael E; Willy, Jeffrey A; Wang, Yongping; Mirek, Emily T; Al Baghdadi, Rana J T; Adams, Christopher M; Anthony, Tracy G; Wek, Ronald C

    2016-05-01

    Disturbances in protein folding and membrane compositions in the endoplasmic reticulum (ER) elicit the unfolded protein response (UPR). Each of three UPR sensory proteins-PERK (PEK/EIF2AK3), IRE1, and ATF6-is activated by ER stress. PERK phosphorylation of eIF2 represses global protein synthesis, lowering influx of nascent polypeptides into the stressed ER, coincident with preferential translation of ATF4 (CREB2). In cultured cells, ATF4 induces transcriptional expression of genes directed by the PERK arm of the UPR, including genes involved in amino acid metabolism, resistance to oxidative stress, and the proapoptotic transcription factor CHOP (GADD153/DDIT3). In this study, we characterize whole-body and tissue-specific ATF4-knockout mice and show in liver exposed to ER stress that ATF4 is not required for CHOP expression, but instead ATF6 is a primary inducer. RNA-Seq analysis indicates that ATF4 is responsible for a small portion of the PERK-dependent UPR genes and reveals a requirement for expression of ATF4 for expression of genes involved in oxidative stress response basally and cholesterol metabolism both basally and under stress. Consistent with this pattern of gene expression, loss of ATF4 resulted in enhanced oxidative damage, and increased free cholesterol in liver under stress accompanied by lowered cholesterol in sera.

  17. Reevaluation of the Braginskii viscous force for toroidal plasma

    CERN Document Server

    Johnson, Robert W

    2009-01-01

    The model by Braginskii for the viscous stress tensor is used to determine the shear and gyroviscous forces acting within a toroidally confined plasma. Comparison is made to previous evaluations which contain an inconsistent treatment of the radial derivative and neglect the effect of the pitch angle. A radial gyroviscous force is found to survive the limit of constant density and rigid toroidal rotation of the flux surface, and a radial shear viscous force may develop for sufficient vertical asymmetry to the ion velocity profile.

  18. Comparative study between toroidal coordinates and the magnetic dipole field

    CERN Document Server

    Chávez-Alarcón, Esteban

    2012-01-01

    There is a similar behaviour between the toroidal coordinates and the dipole magnetic field produced by a circular loop. In this work we evaluate up to what extent the former can be used as a representation of the latter. While the tori in the toroidal coordinates have circular cross sections, those of the circular loop magnetic field are nearly elliptical ovoids, but they are very similar for large aspect ratios.The centres of the latter displace from the axis faster than the former. By making a comparison between tori of similar aspect ratios, we find quantitative criteria to evaluate the accuracy of the approximation.

  19. Development and verification of printed circuit board toroidal transformer model

    DEFF Research Database (Denmark)

    Pejtersen, Jens; Mønster, Jakob Døllner; Knott, Arnold

    2013-01-01

    by comparing calculated parameters with 3D finite element simulations and experimental measurement results. The developed transformer model shows good agreement with the simulated and measured results. The model can be used to predict the parameters of printed circuit board toroidal transformer configurations......An analytical model of an air core printed circuit board embedded toroidal transformer configuration is presented. The transformer has been developed for galvanic isolation of very high frequency switch-mode dc-dc power converter applications. The theoretical model is developed and verified...

  20. Toroidal vortices as a solution to the dust migration problem

    CERN Document Server

    Loren-Aguilar, Pablo

    2015-01-01

    In an earlier letter, we reported that dust settling in protoplanetary discs may lead to a dynamical dust-gas instability that produces global toroidal vortices. In this letter, we investigate the evolution of a dusty protoplanetary disc with two different dust species (1 mm and 50 cm dust grains), under the presence of the instability. We show how toroidal vortices, triggered by the interaction of mm grains with the gas, stop the radial migration of metre-sized dust, potentially offering a natural and efficient solution to the dust migration problem.

  1. Ion temperature gradient modes in toroidal helical systems

    Energy Technology Data Exchange (ETDEWEB)

    Kuroda, T. [Graduate University for Advanced Studies, Toki, Gifu (Japan); Sugama, H.; Kanno, R.; Okamoto, M.

    2000-04-01

    Linear properties of ion temperature gradient (ITG) modes in helical systems are studied. The real frequency, growth rate, and eigenfunction are obtained for both stable and unstable cases by solving a kinetic integral equation with proper analytic continuation performed in the complex frequency plane. Based on the model magnetic configuration for toroidal helical systems like the Large Helical Device (LHD), dependences of the ITG mode properties on various plasma equilibrium parameters are investigated. Particularly, relative effects of {nabla}B-curvature drifts driven by the toroidicity and by the helical ripples are examined in order to compare the ITG modes in helical systems with those in tokamaks. (author)

  2. Effects of Toroidal Rotation Sshear on Toroidicity-induced Alfven Eigenmodes in the National Spherical Torus Experiment

    Energy Technology Data Exchange (ETDEWEB)

    Podesta, M; Fredrickson, E D; Gorelenkov, N N; LeBlanc, B P; Heidbrink, W W; Crocker, N A; Kubota, S

    2010-08-19

    The effects of a sheared toroidal rotation on the dynamics of bursting Toroidicity-induced Alfven eigenmodes are investigated in neutral beam heated plasmas on the National Spherical Torus Experiment (NSTX) [M. Ono et al., Nucl. Fusion 40 557 (2000)]. The modes have a global character, extending over most of the minor radius. A toroidal rotation shear layer is measured at the location of maximum drive for the modes. Contrary to results from other devices, no clear evidence of increased damping is found. Instead, experiments with simultaneous neutral beam and radio-frequency auxiliary heating show a strong correlation between the dynamics of the modes and the instability drive. It is argued that kinetic effects involving changes in the mode drive and damping mechanisms other than rotation shear, such as continuum damping, are mostly responsible for the bursting dynamics of the modes.

  3. Transport and Dynamics in Toroidal Fusion Systems

    Energy Technology Data Exchange (ETDEWEB)

    Sovinec, Carl [Univ. of Wisconsin, Madison, WI (United States)

    2016-09-07

    The study entitled, "Transport and Dynamics in Toroidal Fusion Systems," (TDTFS) applied analytical theory and numerical computation to investigate topics of importance to confining plasma, the fourth state of matter, with magnetic fields. A central focus of the work is how non-thermal components of the ion particle distribution affect the "sawtooth" collective oscillation in the core of the tokamak magnetic configuration. Previous experimental and analytical research had shown and described how the oscillation frequency decreases and amplitude increases, leading to "monster" or "giant" sawteeth, when the non-thermal component is increased by injecting particle beams or by exciting ions with imposed electromagnetic waves. The TDTFS study applied numerical computation to self-consistently simulate the interaction between macroscopic collective plasma dynamics and the non-thermal particles. The modeling used the NIMROD code [Sovinec, Glasser, Gianakon, et al., J. Comput. Phys. 195, 355 (2004)] with the energetic component represented by simulation particles [Kim, Parker, Sovinec, and the NIMROD Team, Comput. Phys. Commun. 164, 448 (2004)]. The computations found decreasing growth rates for the instability that drives the oscillations, but they were ultimately limited from achieving experimentally relevant parameters due to computational practicalities. Nonetheless, this effort provided valuable lessons for integrated simulation of macroscopic plasma dynamics. It also motivated an investigation of the applicability of fluid-based modeling to the ion temperature gradient instability, leading to the journal publication [Schnack, Cheng, Barnes, and Parker, Phys. Plasmas 20, 062106 (2013)]. Apart from the tokamak-specific topics, the TDTFS study also addressed topics in the basic physics of magnetized plasma and in the dynamics of the reversed-field pinch (RFP) configuration. The basic physics work contributed to a study of two-fluid effects on interchange dynamics, where

  4. Controlling the toroidal excitations in metamaterials for high-Q response

    CERN Document Server

    Fan, Yuancheng; Fu, Quanhong; Wei, Zeyong; Li, Hongqiang

    2016-01-01

    The excitation of toroidal multipoles in metamaterials was investigated for high-Q response at a subwavelength scale. In this study, we explored the optimization of toroidal excitations in a planar metamaterial comprised of asymmetric split ring resonators (ASRRs). It was found that the scattering power of toroidal dipole can be remarkably strengthened by adjusting the characteristic parameter of ASRRs: asymmetric factor. Interestingly, the improvement in toroidal excitation accompanies increasing of the Q-factor of the toroidal metamaterial, it is shown that both the scattering power of toroidal dipole and the Q-factor were increased near one order by changing the asymmetric factor of ASRRs. The optimization in excitation of toroidal multipoles provide opportunity to further increase the Q-factor of toroidal metamaterial and boost light-matter interactions at the subwavelength scale for potential applications in low-power nonlinear processing and sensitive photonic applications.

  5. Production of tetraacetyl phytosphingosine (TAPS) in Wickerhamomyces ciferrii is catalyzed by acetyltransferases Sli1p and Atf2p.

    Science.gov (United States)

    Ter Veld, Frank; Wolff, Daniel; Schorsch, Christoph; Köhler, Tim; Boles, Eckhard; Poetsch, Ansgar

    2013-10-01

    Wickerhamomyces ciferrii secretes tetraacetyl phytosphingosine (TAPS), and in this study, the catalyzing acetyltransferases were identified using mass spectrometry-based proteomics. The proteome of wild-type strain NRRL Y-1031 served as control and was compared to the tetraacetyl phytosphingosine defective mating type NRRL Y-1031-27. Acetylation of phytosphingosine in W. ciferrii is catalyzed by acetyltransferases Sli1p and Atf2p, encoded by genes similar to Saccharomyces cerevisiae YGR212W and YGR177C, respectively. Ablation of SLI1 resulted in an almost complete loss of tri- and tetraacetyl phytosphingosines, whereas the loss ATF2 resulted in an 15-fold increase in triacetyl phytosphingosine. Most likely, it is the concerted action of these two acetyltransferases that yields tetraacetyl phytosphingosine, in which Sli1p catalyzes initial O- and N-acetylation, producing triacetyl phytosphingosine. Finally, Atf2p catalyzes final O-acetylation to yield tetraacetyl phytosphingosine. The current study demonstrates that mass spectrometry-based proteomics can be employed to identify key steps in ill-explored metabolite biosynthesis pathways of nonconventional microorganisms. Furthermore, the identification of phytosphingosine as substrate for alcohol acetyltransferase Atf2p broadens the known substrate range of this enzyme. This interesting property of Atf2p may be exploited to enhance the secretion of heterologous compounds.

  6. Stability of toroidal magnetic fields in stellar interiors

    CERN Document Server

    Ibañez-Mejia, Juan C

    2015-01-01

    We present 3D MHD simulations of purely toroidal and mixed poloidal-toroidal magnetic field configurations to study the behavior of the Tayler instability. For the first time the simultaneous action of rotation and magnetic diffusion are taken into account and the effects of a poloidal field on the dynamic evolution of unstable toroidal magnetic fields is included. In the absence of diffusion, fast rotation (rotation rate compared to Alfv\\'en frequency) is able to suppress the instability when the rotation and magnetic axes are aligned and when the radial field strength gradient p 1.5, rapid rotation does not suppress the instability but instead introduces a damping factor to the growth rate in agreement with the analytic predictions. For the mixed poloidal-toroidal fields we find an unstable axisymmetric mode, not predicted analytically, right at the stability threshold for the non-axisymmetric modes; it has been argued that an axisymmetric mode is necessary for the closure of the Tayler-Spruit dynamo loop.

  7. First ATLAS Barrel Toroid coil casing arrives at CERN

    CERN Multimedia

    2002-01-01

    The first of eight 25-metre long coil casings for the ATLAS experiment's barrel toroid magnet system arrived at CERN on Saturday 2 March by road from Heidelberg. This structure will be part of the largest superconducting toroid magnet ever made.   The first coil casing for the toroidal magnets of Atlas arrives at Building 180. This is the start of an enormous three-dimensional jigsaw puzzle. Each of the eight sets of double pancake coils will be housed inside aluminium coil casings, which in turn will be held inside a stainless steel vacuum vessel. A huge construction, the casing that arrived at CERN measures 25 metres in length and 5 metres in width. It weighs 20 tones. And this is just the beginning of the toroid jigsaw: by early April a batch of four double pancake coils, which altogether weighs 65 tones, will arrive from Ansaldo in Italy. The first vacuum vessel will also be arriving from Felguera in Spain this month. It will take about two years for all these 25 m long structures of casings, coils a...

  8. Approximations for the natural logarithm from solenoid-toroid correspondence

    CERN Document Server

    Semiz, Ibrahim

    2015-01-01

    It seems reasonable that a toroid can be thought of approximately as a solenoid bent into a circle. The correspondence of the inductances of these two objects gives an approximation for the natural logarithm in terms of the average of two numbers. Different ways of averaging give different approximants. They are expressions simpler than Taylor polynomials, and are meaningful over a wider domain.

  9. Toroidal equilibrium in an iron-core reversed field pinch

    Energy Technology Data Exchange (ETDEWEB)

    Miller, G.

    1984-04-01

    An analytical theory of toroidal equilibrium in the ZT-40M reversed field pinch is obtained, including effects of iron cores and resistive shell. The iron cores alter the form of the equilibrium condition and cause the equilibrium to be unstable on the shell resistive time scale.

  10. The Superconducting Toroid for the New International AXion Observatory (IAXO)

    CERN Document Server

    Shilon, I; Silva, H; Wagner, U; Kate, H H J ten

    2013-01-01

    IAXO, the new International AXion Observatory, will feature the most ambitious detector for solar axions to date. Axions are hypothetical particles which were postulated to solve one of the puzzles arising in the standard model of particle physics, namely the strong CP (Charge conjugation and Parity) problem. This detector aims at achieving a sensitivity to the coupling between axions and photons of one order of magnitude beyond the limits of the current detector, the CERN Axion Solar Telescope (CAST). The IAXO detector relies on a high-magnetic field distributed over a very large volume to convert solar axions to detectable X-ray photons. Inspired by the ATLAS barrel and end-cap toroids, a large superconducting toroid is being designed. The toroid comprises eight, one meter wide and twenty one meters long racetrack coils. The assembled toroid is sized 5.2 m in diameter and 25 m in length and its mass is about 250 tons. The useful field in the bores is 2.5 T while the peak magnetic field in the windings is 5....

  11. Theory of the M = 1 Kink Mode in Toroidal Plasma

    NARCIS (Netherlands)

    de Blank, H. J.; Schep, T. J.

    1991-01-01

    The energy principle of ideal magnetohydrodynamics (MHD) is used to study the ideal MHD stability of the m = 1 internal kink mode in a toroidal plasma. The equilibrium configurations that are considered allow for a broad region where the safety factor q is close to unity. This region may extend to t

  12. Evidence of Inward Toroidal Momentum Convection in the JET Tokamak

    DEFF Research Database (Denmark)

    Tala, T.; Zastrow, K.-D.; Ferreira, J.

    2009-01-01

    Experiments have been carried out on the Joint European Torus tokamak to determine the diffusive and convective momentum transport. Torque, injected by neutral beams, was modulated to create a periodic perturbation in the toroidal rotation velocity. Novel transport analysis shows the magnitude an...

  13. Toroidal and poloidal momentum transport studies in JET

    DEFF Research Database (Denmark)

    Tala, T.; Andrew, Y.; Crombe, K.

    2007-01-01

    This paper reports on the recent studies of toroidal and poloidal momentum transport in JET. The ratio of the global energy confinement time to the momentum confinement is found to be close to tau(E)/tau(phi) = 1 except for the low density or low collisionality discharges where the ratio is tau(E...

  14. ATLAS-Lowering the first Barrel Toroid coil

    CERN Multimedia

    CERN Audiovisual Unit

    2004-01-01

    Cranes lowered the first of ATLAS's eight Barrel Toroid coils into the cavern. The part is 25 meters long and the cranes had to hold the 100 tonne coil at a sharp angle while it passed through the 18-meter diameter vertical shaft into the cavern. Then they laid the magnet to a horizontal robust platform. Images from Camera 2

  15. ATLAS-Lowering the first Barrel Toroid coil

    CERN Multimedia

    2004-01-01

    Cranes lowered the first of ATLAS's eight Barrel Toroid coils into the cavern. The part is 25 metres long and the cranes had to hold the 100 tonne coil at a sharp angle while it passed through the 18-metre diameter vertical shaft into the cavern. Then they laid the magnet to a horisontal robust platform. Images from Camera 1

  16. Plasma Processes : Minimum dissipative relaxed states in toroidal plasmas

    Indian Academy of Sciences (India)

    R Bhattacharyya; M S Janaki; B Dasgupta

    2000-11-01

    Relaxation of toroidal discharges is described by the principle of minimum energy dissipation together with the constraint of conserved global helicity. The resulting Euler-Lagrange equation is solved in toroidal coordinates for an axisymmetric torus by expressing the solutions in terms of Chandrasekhar-Kendall (C-K) eigenfunctions analytically continued in the complex domain. The C-K eigenfunctions are obtained as hypergeometric functions that are solutions of scalar Helmholtz equation in toroidal coordinates in the large aspect-ratio approximation. Equilibria are constructed by assuming the current to vanish at the edge of plasma. For the = 0; = 0 ( and are the poloidal and toroidal mode numbers respectively) relaxed states, the magnetic field, current, (safety factor) and pressure profiles are calculated for a given value of aspect-ratio of the torus and for different values of the eigenvalue 0. The new feature of the present model is that solutions allow for both tokamak as well as RFP-like behaviour with increase in the values of 0, which is related directly to volt-sec in the experiment.

  17. Flat-band assembly for toroidal transformer cores

    Science.gov (United States)

    Mclyman, W. T.

    1973-01-01

    Toroidal transformer cores are often banded together by means of strap. Spot welds secure strap. Proper tension is obtained by use of special fixture in conjunction with winding of wire which is placed temporarily on core; winding is excited by dc current to hold core halves together magnetically during alignment.

  18. Barrel Toroid fully charged to nominal field, and it works!

    CERN Document Server

    Herman ten Kate

    After a few weeks of testing up to intermediate currents, finally, on Thursday evening November 9, the current in the Barrel Toroid was pushed up to its nominal value of 20500 A and even 500 A beyond this value to prove that we have some margin. It went surprisingly well. Of course, the 8 coils forming the toroid were already tested individually at the surface but still, some surprise may have come from those parts added to the toroid in the cavern for the first time like the 8 cryoring sections linking the coils as well as the valve box at the bottom in sector 13 regulating the helium flow or the current lead cryostat on the top in sector 5. No training quenches, nothing to worry about, and the test was concluded with a fast dump triggered at 00:40 in the very early morning of November 10. (left) The toroid current during the evening and night of November 9. (right) The test crew oscillated between fear and hope while looking at the control panels as the current approached 21kA. Big relief was in the...

  19. Homogeneous Construction of the Toroidal Lie Algebra of Type A1

    Institute of Scientific and Technical Information of China (English)

    Haifeng Lian; Cui Chen; Qinzhu Wen

    2007-01-01

    In this paper,we consider an analogue of the level two homogeneous construc-tion of the affine Kac-Moody algebra A1(1) by vertex operators.We construct modules for the toroidal Lie algebra and the extended toroidal Lie algebra of type A1.We also prove that the module is completely reducible for the extended toroidal Lie algebra.

  20. The characteristics of the ion temperature and toroidal rotation velocity in the KSTAR plasma

    Energy Technology Data Exchange (ETDEWEB)

    Ko, Won Ha; Lee, Hyung Ho; Oh, Seung Tae [National Fusion Research Institute, Daejeon (Korea, Republic of)

    2012-05-15

    Charge exchange spectroscopy (CES) is one of the important diagnostics on the Korea Superconducting Tokamak Advanced Research (KSTAR) to get ion temperature and toroidal rotation velocity. We describe the current status and the improvements made over the last two years. The current system upgraded from a Czerny-Turner spectrometer consists of two spectroscopic systems looking at the KSTAR neutral beam which is modulated 5 Hz for special period. One system has a DS spectrometer (f/2.8) lent from NIFS with pitch-controlled double slit fiber bundle with back- illuminated CCD and the other system has Kspectrometer (F/2.0) made by NFRI with intensified CCD. The K-spectrometer has a grating number of 2400 g/mm, focal length of 200 mm. The upgrade of two high throughput spectrometers enables to improve the time resolution from 200 msec to around 10 msec. This article focuses on improved edge spatial interval from increasing of plasma viewing channels to 5 mm and enhanced time resolution from a high throughput spectrometer with back-illuminated CCD. The upgrade has allowed to measure pedestal ion temperature and toroidal rotation velocity profiles in KSTAR H-mode

  1. The Role of the PERK/eIF2α/ATF4/CHOP Signaling Pathway in Tumor Progression During Endoplasmic Reticulum Stress

    Science.gov (United States)

    Rozpędek, W.; Pytel, D.; Mucha, B.; Leszczyńska, H.; Diehl, J. Alan; Majsterek, I.

    2016-01-01

    Hypoxia is a major hallmark of the tumor microenvironment that is strictly associated with rapid cancer progression and induction of metastasis. Hypoxia inhibits disulfide bond formation and impairs protein folding in the Endoplasmic Reticulum (ER). The stress in the ER induces the activation of Unfolded Protein Response (UPR) pathways via the induction of protein kinase RNA-like endoplasmic reticulum kinase (PERK). As a result, the level of phosphorylated Eukaryotic Initiation Factor 2 alpha (eIF2α) is markedly elevated, resulting in the promotion of a pro-adaptive signaling pathway by the inhibition of global protein synthesis and selective translation of Activating Transcription Factor 4 (ATF4). On the contrary, during conditions of prolonged ER stress, pro-adaptive responses fail and apoptotic cell death ensues. Interestingly, similar to the activity of the mitochondria, the ER may also directly activate the apoptotic pathway through ER stress-mediated leakage of calcium into the cytoplasm that leads to the activation of death effectors. Apoptotic cell death also ensues by ATF4-CHOP- mediated induction of several pro-apoptotic genes and suppression of the synthesis of anti-apoptotic Bcl-2 proteins. Advancing molecular insight into the transition of tumor cells from adaptation to apoptosis under hypoxia-induced ER stress may provide answers on how to overcome the limitations of current anti-tumor therapies. Targeting components of the UPR pathways may provide more effective elimination of tumor cells and as a result, contribute to the development of more promising anti-tumor therapeutic agents. PMID:27211800

  2. The Role of the PERK/eIF2α/ATF4/CHOP Signaling Pathway in Tumor Progression During Endoplasmic Reticulum Stress.

    Science.gov (United States)

    Rozpedek, W; Pytel, D; Mucha, B; Leszczynska, H; Diehl, J A; Majsterek, I

    2016-01-01

    Hypoxia is a major hallmark of the tumor microenvironment that is strictly associated with rapid cancer progression and induction of metastasis. Hypoxia inhibits disulfide bond formation and impairs protein folding in the Endoplasmic Reticulum (ER). The stress in the ER induces the activation of Unfolded Protein Response (UPR) pathways via the induction of protein kinase RNA-like endoplasmic reticulum kinase (PERK). As a result, the level of phosphorylated Eukaryotic Initiation Factor 2 alpha (eIF2α) is markedly elevated, resulting in the promotion of a pro-adaptive signaling pathway by the inhibition of global protein synthesis and selective translation of Activating Transcription Factor 4 (ATF4). On the contrary, during conditions of prolonged ER stress, pro-adaptive responses fail and apoptotic cell death ensues. Interestingly, similar to the activity of the mitochondria, the ER may also directly activate the apoptotic pathway through ER stress-mediated leakage of calcium into the cytoplasm that leads to the activation of death effectors. Apoptotic cell death also ensues by ATF4-CHOP- mediated induction of several pro-apoptotic genes and suppression of the synthesis of anti-apoptotic Bcl-2 proteins. Advancing molecular insight into the transition of tumor cells from adaptation to apoptosis under hypoxia-induced ER stress may provide answers on how to overcome the limitations of current anti-tumor therapies. Targeting components of the UPR pathways may provide more effective elimination of tumor cells and as a result, contribute to the development of more promising anti-tumor therapeutic agents.

  3. Toroidal modeling of plasma response to RMP fields in ITER

    Science.gov (United States)

    Li, L.; Liu, Y. Q.; Wang, N.; Kirk, A.; Koslowski, H. R.; Liang, Y.; Loarte, A.; Ryan, D.; Zhong, F. C.

    2017-04-01

    A systematic numerical study is carried out, computing the resistive plasma response to the resonant magnetic perturbation (RMP) fields for ITER plasmas, utilizing the toroidal code MARS-F (Liu et al 2000 Phys. Plasmas 7 3681). A number of factors are taken into account, including the variation of the plasma scenarios (from 15 MA Q = 10 inductive scenario to the 9 MA Q = 5 steady state scenario), the variation of the toroidal spectrum of the applied fields (n = 1, 2, 3, 4, with n being the toroidal mode number), the amplitude and phase variation of the currents in three rows of the RMP coils as designed for ITER, and finally a special case of mixed toroidal spectrum between the n = 3 and n = 4 RMP fields. Two-dimensional parameter scans, for the edge safety factor and the coil phasing between the upper and lower rows of coils, yield ‘optimal’ curves that maximize a set of figures of merit, that are defined in this work to measure the plasma response. Other two-dimensional scans of the relative coil current phasing among three rows of coils, at fixed coil currents amplitude, reveal a single optimum for each coil configuration with a given n number, for the 15 MA ITER inductive plasma. On the other hand, scanning of the coil current amplitude, at fixed coil phasing, shows either synergy or cancellation effect, for the field contributions between the off-middle rows and the middle row of the RMP coils. Finally, the mixed toroidal spectrum, by combining the n = 3 and the n = 4 RMP field, results in a substantial local reduction of the amplitude of the plasma surface displacement.

  4. Geometric wakefield regimes study of a rectangular tapered collimator for ATF2

    CERN Document Server

    Fuster-Martinez, Nuria; Latina, Andrea; Snuverink, Jochem

    2016-01-01

    In this paper we study the discrepancy found between the wakefield impact effect induced by a rectangular tapered collimator prototype for ATF2 calculated using analytical models, calculated from CST PS numerical simulations and implemented in the tracking code PLACET v1.0.0. In order to get consistent results between the analytical calculations, CST PS simulations and the tracking code PLACET v1.0.0 the collimator wakefield module in PLACET v1.0.0 has to be modified. The changes have been implemented in the tracking code PLACET v1.0.1.

  5. Development and quality assessments of commercial heat production of ATF FeCrAl tubes

    Energy Technology Data Exchange (ETDEWEB)

    Yamamoto, Yukinori [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2015-09-01

    Development and quality assessment of the 2nd generation ATF FeCrAl tube production with commercial manufacturers were conducted. The manufacturing partners include Sophisticated Alloys, Inc. (SAI), Butler, PA for FeCrAl alloy casting via vacuum induction melting, Oak Ridge National Laboratory (ORNL) for extrusion process to prepare the master bars/tubes to be tube-drawn, and Rhenium Alloys, Inc. (RAI), North Ridgeville, OH, for tube-drawing process. The masters bars have also been provided to Los Alamos National Laboratory (LANL) who works with Century Tubes, Inc., (CTI), San Diego, CA, as parallel tube production effort under the current program.

  6. Transcriptional upregulation of DDR2 by ATF4 facilitates osteoblastic differentiation through p38 MAPK-mediated Runx2 activation.

    Science.gov (United States)

    Lin, Kuan-Liang; Chou, Ching-Heng; Hsieh, Shu-Chen; Hwa, Su-Yang; Lee, Ming-Ta; Wang, Fung-Fang

    2010-11-01

    Deficiency of the collagen receptor discoidin domain receptor tyrosine kinase (DDR2) in mice and humans results in dwarfism and short limbs, of which the mechanism remains unknown. Here we report that DDR2 is a key regulator of osteoblast differentiation. DDR2 mRNA expression was increased at an early stage of induced osteoblast differentiation. In the subchondral bone of human osteoarthritic knee, DDR2 was detected in osteoblastic cells. In mouse embryos, DDR2 expression was found from E11 to E15, preceding osteocalcin (OCN) and coinciding with Runx2 expression. Activating transcription factor 4 (ATF4) enhanced DDR2 mRNA expression, and knockdown of ATF4 expression delayed DDR2 induction during osteoblast differentiation. A CCAAT/enhancer binding protein (C/EBP) binding site at -1150 bp in the DDR2 promoter was required for ATF4-mediated DDR2 activation. C/EBPβ bound to and cooperated with ATF4 in stimulating DDR2 transcription; accordingly, the ATF4 mutants deficient of C/EBPβ binding were incapable of transactivating DDR2. Overexpression of DDR2 increased osteoblast-specific gene expression. Conversely, knockdown of DDR2 suppressed osteogenic marker gene expression and matrix mineralization during the induced osteogenesis. The stimulation of p38 MAPK by DDR2 was required for DDR2-induced activation of Runx2 and OCN promoters. Together our findings uncover a pathway in which ATF4, by binding to C/EBPβ transcriptionally upregulates DDR2 expression, and DDR2, in turn, activates Runx2 through p38 MAPK to promote osteoblast differentiation.

  7. Role of ATF7-TAF12 interactions in the vitamin D response hypersensitivity of osteoclast precursors in Paget's disease.

    Science.gov (United States)

    Teramachi, Jumpei; Hiruma, Yuko; Ishizuka, Seiichi; Ishizuka, Hisako; Brown, Jacques P; Michou, Laëtitia; Cao, Huiling; Galson, Deborah L; Subler, Mark A; Zhou, Hua; Dempster, David W; Windle, Jolene J; Roodman, G David; Kurihara, Noriyoshi

    2013-06-01

    Osteoclast (OCL) precursors from many Paget's disease (PD) patients express measles virus nucleocapsid protein (MVNP) and are hypersensitive to 1,25-dihydroxyvitamin D₂ (1,25-(OH)₂D₃; also know as calcitriol). The increased 1,25-(OH)₂D₃ sensitivity is mediated by transcription initiation factor TFIID subunit 12 (TAF12), a coactivator of the vitamin D receptor (VDR), which is present at much higher levels in MVNP-expressing OCL precursors than normals. These results suggest that TAF12 plays an important role in the abnormal OCL activity in PD. However, the molecular mechanisms underlying both 1,25-(OH)₂D₃'s effects on OCL formation and the contribution of TAF12 to these effects in both normals and PD patients are unclear. Inhibition of TAF12 with a specific TAF12 antisense construct decreased OCL formation and OCL precursors' sensitivity to 1,25-(OH)₂D₃ in PD patient bone marrow samples. Further, OCL precursors from transgenic mice in which TAF12 expression was targeted to the OCL lineage (tartrate-resistant acid phosphatase [TRAP]-TAF12 mice), formed OCLs at very low levels of 1,25-(OH)₂D₃, although the OCLs failed to exhibit other hallmarks of PD OCLs, including receptor activator of NF-κB ligand (RANKL) hypersensitivity and hypermultinucleation. Chromatin immunoprecipitation (ChIP) analysis of OCL precursors using an anti-TAF12 antibody demonstrated that TAF12 binds the 24-hydroxylase (CYP24A1) promoter, which contains two functional vitamin D response elements (VDREs), in the presence of 1,25-(OH)₂D₃. Because TAF12 directly interacts with the cyclic adenosine monophosphate-dependent activating transcription factor 7 (ATF7) and potentiates ATF7-induced transcriptional activation of ATF7-driven genes in other cell types, we determined whether TAF12 is a functional partner of ATF7 in OCL precursors. Immunoprecipitation of lysates from either wild-type (WT) or MVNP-expressing OCL with an anti-TAF12 antibody, followed by blotting with an

  8. Observation of Fano resonance and classical analog of electromagnetically induced transparency in toroidal metamaterials

    Energy Technology Data Exchange (ETDEWEB)

    Han, Song; Yang, Helin [College of Physical Science and Technology, Central China Normal University, Wuhan (China); Cong, Lonqing; Singh, Ranjan [Division of Physics and Applied Physics, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore (Singapore); Centre for Disruptive Photonic Technologies, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore (Singapore); Gao, Fei [Division of Physics and Applied Physics, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore (Singapore)

    2016-05-15

    Toroidal multipoles have recently been explored in various scientific communities, ranging from atomic and molecular physics, electrodynamics, and solid-state physics to biology. Here we experimentally and numerically demonstrate a three-dimensional toroidal metamaterial where two different toroidal dipoles along orthogonal directions have been observed. The chosen toroidal metamaterial also simultaneously supports Fano resonance and the classical analog of electromagnetically induced transparency (EIT) phenomena in the transmission spectra that originate from the electric-toroidal dipole and electric-magnetic dipole destructive interference. The intriguing properties of the toroidal resonances may open up avenues for applications in toroidal moments generator, sensing and slow-light devices. (copyright 2016 by WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  9. Non-destructive Preirradiation Assessment of UN / U-Si “LANL1” ATF formulation

    Energy Technology Data Exchange (ETDEWEB)

    Vogel, Sven C. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Losko, Adrian Simon [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Pokharel, Reeju [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Ickes, Timothy Lee [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Hunter, James F. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Brown, Donald William [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Voit, Stewart Lancaster [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Tremsin, Anton S. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Bourke, Mark Andrew [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); McClellan, Kenneth James [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-09-15

    The goal of the Advanced Non-destructive Fuel Examination (ANDE) work package is the development and application of non-destructive neutron imaging and scattering techniques to ceramic and metallic nuclear fuels, ultimately also to irradiated fuels. The results of these characterizations provide complete pre- and post-irradiation on length scales ranging from mm to nm, guide destructive examination, and inform modelling efforts. Besides technique development and application to samples to be irradiated, the ANDE work package also examines possible technologies to provide these characterization techniques pool-side, e.g. at the Advanced Test Reactor (ATR) at Idaho National Laboratory (INL) using laser-driven intense pulsed neutron and gamma sources. Neutron tomography and neutron diffraction characterizations were performed on nine pellets; four UN/ U-Si composite formulations (two enrichment levels), three pure U3Si5 reference formulations (two enrichment levels), and two reject pellets with visible flaws (to qualify the technique). The 235U enrichments ranged from 0.2 to 8.8 wt. %. The nitride/silicide composites are candidate compositions for use as Accident Tolerant Fuel (ATF). The monophase U3Si5 material was included as a reference. Pellets from the same fabrication batches will be inserted in the Advanced Test Reactor at Idaho during 2016. We have also proposed a data format to build a database for characterization results of individual pellets. Neutron data reported in this report were collected in the LANSCE run cycle that started in September 2015 and ended in March 2016. This report provides the results for the characterized samples and discussion in the context of ANDE and APIE. We quantified the gamma spectra of several samples in their received state as well as after neutron irradiation to ensure that the neutron irradiation does not add significant activation that would complicate shipment and

  10. Characterization of compact-toroid injection during formation, translation, and field penetration

    Science.gov (United States)

    Matsumoto, T.; Roche, T.; Allfrey, I.; Sekiguchi, J.; Asai, T.; Gota, H.; Cordero, M.; Garate, E.; Kinley, J.; Valentine, T.; Waggoner, W.; Binderbauer, M.; Tajima, T.

    2016-11-01

    We have developed a compact toroid (CT) injector system for particle refueling of the advanced beam-driven C-2U field-reversed configuration (FRC) plasma. The CT injector is a magnetized coaxial plasma gun (MCPG), and the produced CT must cross the perpendicular magnetic field surrounding the FRC for the refueling of C-2U. To simulate this environment, an experimental test stand has been constructed. A transverse magnetic field of ˜1 kG is established, which is comparable to the C-2U axial magnetic field in the confinement section, and CTs are fired across it. On the test stand we have been characterizing and studying CT formation, ejection/translation from the MCPG, and penetration into transverse magnetic fields.

  11. Development of Multi-pulse Compact Toroid Injector System for C-2U

    Science.gov (United States)

    Allfrey, I.; Garate, E.; Morehouse, M.; Roche, T.; Gota, H.; Valentine, T.; Waggoner, W.; Putvinski, S.; Cordero, M.; Asai, T.; Matsumoto, T.; Sekiguchi, J.; the TAE Team

    2015-11-01

    The C-2U experiment aims at sustaining a dynamically formed field reversed configuration (FRC) for 5 + ms via injection of 10 +MW of neutral beams. One of the systems currently used to refuel the C-2U plasma is a single pulse compact toroid injector (CTI). The CTI is a magnetized co-axial plasma gun, which generates a spheromak-like plasma that is injected into the core of the advanced beam-driven FRC of C-2U. In order to refuel the recent long-lived plasmas in C-2U, a multi-pulse CTI system, whose modular design allows for expandable burst numbers, is being designed. Details of the pulsed power systems used to energize the single pulse and the upgraded multi-pulse CTI will be discussed. Results of injector performance carried out on a dedicated test stand as well as some refueling data on C-2U will also be presented.

  12. Prospects for searching axion-like particle dark matter with dipole, toroidal and wiggler magnets

    Energy Technology Data Exchange (ETDEWEB)

    Baker, Oliver K. [Yale Univ., New Haven, CT (United States). Dept. of Physics; Betz, Michael; Caspers, Fritz [European Organization for Nuclear Research (CERN), Geneva (Switzerland); Jaeckel, Joerg [Institute for Particle Physics Phenomenology, Durham (United Kingdom); Lindner, Axel; Ringwald, Andreas [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany); Semertzidis, Yannis [Brookhaven National Lab., Upton, NY (United States); Sikivie, Pierre [Florida Univ., Gainesville, FL (United States). Dept. of Physics; Zioutas, Konstantin [Patras Univ. (Greece)

    2011-10-15

    In this work we consider searches for dark matter made of axions or axion-like particles (ALPs) using resonant radio frequency cavities inserted into dipole magnets from particle accelerators, wiggler magnets developed for accelerator based advanced light sources, and toroidal magnets similar to those used in particle physics detectors. We investigate the expected sensitivity of such ALP dark matter detectors and discuss the engineering aspects of building and tuning them. Brief mention is also made of even stronger field magnets that are becoming available due to improvements in magnetic technology. It is concluded that new experiments utilizing already existing magnets could greatly enlarge the mass region in searches for axion-like dark matter particles. (orig.)

  13. Reevaluation of the Braginskii viscous force for toroidal plasma

    Science.gov (United States)

    Johnson, Robert W.

    2011-12-01

    The model by Braginskii [1] (Braginskii, S. I. 1965 Transport processes in plasma. In: Review of Plasma Physics, Vol. 1 (ed. M.A. Leontovich). New York, NY: Consultants Bureau, pp. 205-311) for the viscous stress tensor is used to determine the shear and gyroviscous forces acting within a toroidally confined plasma. Comparison is made to a previous evaluation, which contains an inconsistent treatment of the radial derivative and neglects the effect of the pitch angle. Parallel viscosity contributes a radial shear viscous force, which may develop for sufficient vertical asymmetry to the ion velocity profile. An evaluation is performed of this radial viscous force for a tokamak near equilibrium, which indicates qualitative agreement between theory and measurement for impure plasma discharges with strong toroidal flow.

  14. Modelling of density limit phenomena in toroidal helical plasmas

    Energy Technology Data Exchange (ETDEWEB)

    Itoh, Kimitaka [National Inst. for Fusion Science, Toki, Gifu (Japan); Itoh, Sanae-I. [Kyushu Univ., Fukuoka (Japan). Research Inst. for Applied Mechanics; Giannone, Louis [EURATOM-IPP Association, Max Planck Institut fuer Plasmaphysik, Garching (Germany)

    2001-11-01

    The physics of density limit phenomena in toroidal helical plasmas based on an analytic point model of toroidal plasmas is discussed. The combined mechanism of the transport and radiation loss of energy is analyzed, and the achievable density is derived. A scaling law of the density limit is discussed. The dependence of the critical density on the heating power, magnetic field, plasma size and safety factor in the case of L-mode energy confinement is explained. The dynamic evolution of the plasma energy and radiation loss is discussed. Assuming a simple model of density evolution, of a sudden loss of density if the temperature becomes lower than critical value, then a limit cycle oscillation is shown to occur. A condition that divides the limit cycle oscillation and the complete radiation collapse is discussed. This model seems to explain the density limit oscillation that has been observed on the Wendelstein 7-AS (W7-AS) stellarator. (author)

  15. Modelling of density limit phenomena in toroidal helical plasmas

    Energy Technology Data Exchange (ETDEWEB)

    Itoh, K. [National Inst. for Fusion Science, Toki, Gifu (Japan); Itoh, S.-I. [Kyushu Univ., Fukuoka (Japan). Research Inst. for Applied Mechanics; Giannone, L. [Max Planck Institut fuer Plasmaphysik, EURATOM-IPP Association, Garching (Germany)

    2000-03-01

    The physics of density limit phenomena in toroidal helical plasmas based on an analytic point model of toroidal plasmas is discussed. The combined mechanism of the transport and radiation loss of energy is analyzed, and the achievable density is derived. A scaling law of the density limit is discussed. The dependence of the critical density on the heating power, magnetic field, plasma size and safety factor in the case of L-mode energy confinement is explained. The dynamic evolution of the plasma energy and radiation loss is discussed. Assuming a simple model of density evolution, of a sudden loss of density if the temperature becomes lower than critical value, then a limit cycle oscillation is shown to occur. A condition that divides the limit cycle oscillation and the complete radiation collapse is discussed. This model seems to explain the density limit oscillation that has been observed on the W7-AS stellarator. (author)

  16. Experimental investigation of transitional flow in a toroidal pipe

    CERN Document Server

    Kühnen, J; Hof, B; Kuhlmann, H

    2015-01-01

    The flow instability and further transition to turbulence in a toroidal pipe (torus) with curvature (tube-to-coiling diameter) 0.049 is investigated experimentally. The flow inside the toroidal pipe is driven by a steel sphere fitted to the inner pipe diameter. The sphere is moved with constant azimuthal velocity from outside the torus by a moving magnet. The experiment is designed to investigate curved pipe flow by optical measurement techniques. Using stereoscopic particle image velocimetry, laser Doppler velocimetry and pressure drop measurements, the flow is measured for Reynolds numbers ranging from 1000 to 15000. Time- and space-resolved velocity fields are obtained and analysed. The steady axisymmetric basic flow is strongly influenced by centrifugal effects. On an increase of the Reynolds number we find a sequence of bifurcations. For Re=4075 a supercritical bifurcation to an oscillatory flow is found in which waves travel in the streamwise direction with a phase velocity slightly faster than the mean...

  17. Initial value problem of the toroidal ion temperature gradient mode

    Energy Technology Data Exchange (ETDEWEB)

    Kuroda, T.; Sugama, H.; Kanno, R.; Okamoto, M. [National Inst. for Fusion Science, Toki, Gifu (Japan); Horton, W.

    1998-06-01

    The initial value problem of the toroidal ion temperature gradient mode is studied based on the Laplace transform of the ion gyrokinetic equation and the electron Boltzmann relation with the charge neutrality condition. Due to the toroidal magnetic drift, the Laplace-transformed density and potential perturbations have a branch cut as well as poles on the complex-frequency plane. The inverse Laplace transform shows that the temporal evolution of the density and potential perturbations consists of the normal modes and the continuum mode, which correspond to contributions from the poles and the branch cut, respectively. The normal modes have exponential time dependence with the eigenfrequencies determined by the dispersion relation while the continuum mode shows power-law decay oscillation. For the stable case, the long-time asymptotic behavior of the potential and density perturbations is dominated by the continuum mode which decays slower than the normal modes. (author)

  18. Low-frequency fluctuations in a pure toroidal magnetized plasma

    Indian Academy of Sciences (India)

    P K Sharma; R Singh; D Bora

    2009-12-01

    A magnetized, low- plasma in pure toroidal configuration is formed and extensively studied with ion mass as control parameter. Xenon, krypton and argon plasmas are formed at a fixed toroidal magnetic field of 0.024 T, with a peak density of ∼ 1011 cm-3, ∼ 4 × 1010 cm-3 and ∼ 2 × 1010 cm−3 respectively. The experimental investigation of time-averaged plasma parameter reveals that their profiles remain insensitive to ion mass and suggests that saturated slab equilibrium is obtained. Low-frequency (LF) coherent fluctuations ( < ci) are observed and identified as flute modes. Here ci represents ion cyclotron frequency. Our results indicate that these modes get reduced with ion mass. The frequency of the fluctuating mode decreases with increase in the ion mass. Further, an attempt has been made to discuss the theory of flute modes to understand the relevance of some of our experimental observations.

  19. Precession of Toroidally Passing Particles in Tokamaks and Spherical Tori

    Energy Technology Data Exchange (ETDEWEB)

    Ya.I. Kolesnichenko; R.B.White; Yu.V. Yakovenko

    2003-01-30

    The toroidal precession of the well-circulating particles and particles that are passing toroidally but trapped poloidally is studied. Expressions for the precession frequency, which are convenient for practical use, are obtained and analyzed. It is found that the key parameters that determine the magnitude and the direction of the precession velocity are the plasma elongation, the magnitudes and profiles of the safety factor and beta defined as the ratio of the local plasma pressure to the magnetic field pressure at the magnetic axis. An important role of the ''paramagnetic'' precession in highly elongated plasmas is revealed. The analysis carried out is based on the obtained expressions for the equilibrium magnetic field strength and the field line curvature.

  20. ATLAS barrel toroid integration and test area in building 180

    CERN Multimedia

    Maximilien Brice

    2003-01-01

    The ATLAS barrel toroid system consists of eight coils, each of axial length 25.3 m, assembled radially and symmetrically around the beam axis. The coils are of a flat racetrack type with two 'double-pancake' windings made of 20.5 kA aluminium-stabilized niobium-titanium superconductor. The barrel toroid is being assembled in building 180 on the Meyrin site. In the first phase of assembly, the coils are packed into their aluminium-alloy casing. These photos show the double-pancake coils from ANSALDO and the coil casings from ALSTOM. In the foreground is the tooling from COSMI used to turn over the coil casings during this first phase. In the right background is the yellow lifting gantry manufactured at JINR-Dubna, Russia which will transport the coil casings to a heating table for prestressing. Two test benches with magnetic mirror are also visible.

  1. Quasars a supermassive rotating toroidal black hole interpretation

    CERN Document Server

    Spivey, R J

    2000-01-01

    A supermassive rotating toroidal black hole (TBH) is proposed as the fundamental structure of quasars and other jet-producing active galactic nuclei. Rotating protogalaxies gather matter from the central gaseous region leading to the birth of massive toroidal stars whose internal nuclear reactions proceed very rapidly. Once the nuclear fuel is spent, gravitational collapse produces a slender ring-shaped TBH remnant. These events are typically the first supernovae of the host galaxies. Given time the TBH mass increases through continued accretion by several orders of magnitude, the event horizon swells whilst the central aperture shrinks. The difference in angular velocities between the accreting matter and the TBH induces a magnetic field that is strongest in the region of the central aperture and innermost ergoregion. Due to the presence of negative energy states when such a gravitational vortex is immersed in an electromagnetic field, circumstances are near ideal for energy extraction via non-thermal radiat...

  2. Radial Eigenmodes for a Toroidal Waveguide with Rectangular Cross Section

    Energy Technology Data Exchange (ETDEWEB)

    Rui Li

    2012-07-01

    In applying mode expansion to solve the CSR impedance for a section of toroidal vacuum chamber with rectangular cross section, we identify the eigenvalue problem for the radial eigenmodes which is different from that for cylindrical structures. In this paper, we present the general expressions of the radial eigenmodes, and discuss the properties of the eigenvalues on the basis of the Sturm-Liouville theory.

  3. 3D toroidal physics: Testing the boundaries of symmetry breakinga)

    Science.gov (United States)

    Spong, Donald A.

    2015-05-01

    Toroidal symmetry is an important concept for plasma confinement; it allows the existence of nested flux surface MHD equilibria and conserved invariants for particle motion. However, perfect symmetry is unachievable in realistic toroidal plasma devices. For example, tokamaks have toroidal ripple due to discrete field coils, optimized stellarators do not achieve exact quasi-symmetry, the plasma itself continually seeks lower energy states through helical 3D deformations, and reactors will likely have non-uniform distributions of ferritic steel near the plasma. Also, some level of designed-in 3D magnetic field structure is now anticipated for most concepts in order to provide the plasma control needed for a stable, steady-state fusion reactor. Such planned 3D field structures can take many forms, ranging from tokamaks with weak 3D edge localized mode suppression fields to stellarators with more dominant 3D field structures. This motivates the development of physics models that are applicable across the full range of 3D devices. Ultimately, the questions of how much symmetry breaking can be tolerated and how to optimize its design must be addressed for all fusion concepts. A closely coupled program of simulation, experimental validation, and design optimization is required to determine what forms and amplitudes of 3D shaping and symmetry breaking will be compatible with the requirements of future fusion reactors.

  4. Toroidal Continuously Variable Transmission Systems: Terminology and Present Studies

    Directory of Open Access Journals (Sweden)

    Ahmet YILDIZ

    2014-04-01

    Full Text Available The use of continuously variable transmission systems in many different areas such as aerospace, robotics, machinery and automotive industries as an alternative to conventional speed changers with constant ratio becomes widely.Especially in the automotive industry, these systems have been used increasingly, since they enable that internal combustion engines in vehicles run at optimal speeds, and consequently provide considerable fuel savings and therefore lower emission values and also they provide powerful acceleration and quiet working. CVT systems have several constructive variants such as belted, chained, balled, toroidal etc. In this paper, toroidal CVT systems based on elastohydrodynamic principles are concerned with, and fundamental works of last two decades in this field are reviewed. However, the relevant terminology and dynamics along with the control of these systems are briefly treated for better understanding of the literature mentioned. Attention is drawn to the lack of some significant issues in present research works, and potential future works are pointed out. This paper, to the authors’ knowledge, will be the first review on toroidal CVT systems in Turkish literature

  5. The Geometry on Smooth Toroidal Compactifications of Siegel varieties

    CERN Document Server

    Yau, Shing-Tung

    2012-01-01

    This is a part of our joint program. The purpose of this paper is to study smooth toroidal compactifications of Siegel varieties and their applications, we also try to understand the K\\"ahler-Einstein metrics on Siegel varieties through the compactifications. Let $A_{g,\\Gamma}:=H_g/\\Gamma$ be a Siegel variety, where $H_g$ is the genus-$g$ Siegel space and $\\Gamma$ is an arithmetic subgroup in $\\Aut(H_g)$. There are four aspects of this paper : 1.There is a correspondence between the category of degenerations of Abelian varieties and the category of limits of weight one Hodge structures. We show that any cusp of Siegel space $\\frak{H}_g$ can be identified with the set of certain weight one polarized mixed Hodge structures. 2.In general, the boundary of a smooth toroidal compactification $\\bar{A}_{g,\\Gamma}$ of $A_{g,\\Gamma}$ has self-intersections.For most geometric applications, we would like to have a nice toroidal compactification such that the added infinity boundary $D_\\infty =\\bar{A}_{g,\\Gamma}-A_{g,\\Gam...

  6. 3D toroidal physics: Testing the boundaries of symmetry breaking

    Energy Technology Data Exchange (ETDEWEB)

    Spong, Donald A., E-mail: spongda@ornl.gov [Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831-6169 (United States)

    2015-05-15

    Toroidal symmetry is an important concept for plasma confinement; it allows the existence of nested flux surface MHD equilibria and conserved invariants for particle motion. However, perfect symmetry is unachievable in realistic toroidal plasma devices. For example, tokamaks have toroidal ripple due to discrete field coils, optimized stellarators do not achieve exact quasi-symmetry, the plasma itself continually seeks lower energy states through helical 3D deformations, and reactors will likely have non-uniform distributions of ferritic steel near the plasma. Also, some level of designed-in 3D magnetic field structure is now anticipated for most concepts in order to provide the plasma control needed for a stable, steady-state fusion reactor. Such planned 3D field structures can take many forms, ranging from tokamaks with weak 3D edge localized mode suppression fields to stellarators with more dominant 3D field structures. This motivates the development of physics models that are applicable across the full range of 3D devices. Ultimately, the questions of how much symmetry breaking can be tolerated and how to optimize its design must be addressed for all fusion concepts. A closely coupled program of simulation, experimental validation, and design optimization is required to determine what forms and amplitudes of 3D shaping and symmetry breaking will be compatible with the requirements of future fusion reactors.

  7. Toroidal mode number estimation of the edge-localized modes using the KSTAR 3-D electron cyclotron emission imaging system

    Energy Technology Data Exchange (ETDEWEB)

    Lee, J.; Yun, G. S., E-mail: gunsu@postech.ac.kr; Lee, J. E.; Kim, M.; Choi, M. J.; Lee, W. [Pohang University of Science and Technology, Pohang 790-784 (Korea, Republic of); Park, H. K. [Ulsan National Institute of Science and Technology, Ulsan 689-798 (Korea, Republic of); Domier, C. W.; Luhmann, N. C. [University of California at Davis, Davis, California 95616 (United States); Sabbagh, S. A.; Park, Y. S. [Columbia University, New York, New York 10027 (United States); Lee, S. G.; Bak, J. G. [National Fusion Research Institute, Daejeon 305-333 (Korea, Republic of)

    2014-06-15

    A new and more accurate technique is presented for determining the toroidal mode number n of edge-localized modes (ELMs) using two independent electron cyclotron emission imaging (ECEI) systems in the Korea Superconducting Tokamak Advanced Research (KSTAR) device. The technique involves the measurement of the poloidal spacing between adjacent ELM filaments, and of the pitch angle α{sub *} of filaments at the plasma outboard midplane. Equilibrium reconstruction verifies that α{sub *} is nearly constant and thus well-defined at the midplane edge. Estimates of n obtained using two ECEI systems agree well with n measured by the conventional technique employing an array of Mirnov coils.

  8. Concentrated bovine milk whey active proteins facilitate osteogenesis through activation of the JNK-ATF4 pathway.

    Science.gov (United States)

    Tsuji-Naito, Kentaro; Jack, Ralph W

    2012-01-01

    Concentrated fractions of low molecular weight whey proteins (1-30 kDa), that is concentrated bovine milk whey active proteins (CBP), have been found to enhance bone formation in both in vivo and clinical studies, but the underlying mechanisms are poorly understood. In this study, we found that CBP promoted osteoblastic differentiation in normal human osteoblasts, and determined the involvement of the c-jun NH2-terminal kinase (JNK)-activating transcription factor 4 (ATF4) pathway. We observed that alkaline phosphatase activity and mineralization were significantly induced by CBP treatment. In addition, mRNA expression of ATF4 was intensely elevated in CBP-treated osteoblasts, indicating that the late-phase events of differentiation were promoted. We found that CBP activated the phosphorylation of JNK and extracellular signal-regulated kinase (ERK). Furthermore, pathway analyses using the various signaling pathway-specific inhibitors revealed that JNK activation, but not ERK activation, is essential for CBP-induced mineralization and ATF4 expression. Our results indicate that the JNK-mediated ATF4 pathway is required for CBP-promotive osteogenesis.

  9. Coffee Polyphenols Change the Expression of STAT5B and ATF-2 Modifying Cyclin D1 Levels in Cancer Cells

    Directory of Open Access Journals (Sweden)

    Carlota Oleaga

    2012-01-01

    Full Text Available Background. Epidemiological studies suggest that coffee consumption reduces the risk of cancer, but the molecular mechanisms of its chemopreventive effects remain unknown. Objective. To identify differentially expressed genes upon incubation of HT29 colon cancer cells with instant caffeinated coffee (ICC or caffeic acid (CA using whole-genome microarrays. Results. ICC incubation of HT29 cells caused the overexpression of 57 genes and the underexpression of 161, while CA incubation induced the overexpression of 12 genes and the underexpression of 32. Using Venn-Diagrams, we built a list of five overexpressed genes and twelve underexpressed genes in common between the two experimental conditions. This list was used to generate a biological association network in which STAT5B and ATF-2 appeared as highly interconnected nodes. STAT5B overexpression was confirmed at the mRNA and protein levels. For ATF-2, the changes in mRNA levels were confirmed for both ICC and CA, whereas the decrease in protein levels was only observed in CA-treated cells. The levels of cyclin D1, a target gene for both STAT5B and ATF-2, were downregulated by CA in colon cancer cells and by ICC and CA in breast cancer cells. Conclusions. Coffee polyphenols are able to affect cyclin D1 expression in cancer cells through the modulation of STAT5B and ATF-2.

  10. Finding ATF4/p75NTR/IL-8 Signal Pathway in Endothelial–Mesenchymal Transition by Safrole Oxide

    Science.gov (United States)

    Zhao, Wenbo; Yue, Hongwei; Su, Le; Zhang, ShangLi; Zhao, Jing

    2014-01-01

    Targeting the endothelial-to-mesenchymal transition (EndoMT) may be a novel therapeutic strategy for cancer and various diseases induced by fibrosis. We aimed to identify a small chemical molecule as an inducer of EndoMT and find a new signal pathway by using the inducer. Safrole oxide (SFO), 50 µg/ml, could most effectively induce EndoMT within 12 h. To understand the underlying molecular mechanism, we performed microarray, quantitative real-time PCR and western blot analysis to find key factors involved in SFO-induced EndoMT and demonstrated the involvement of the factors by RNAi. The expression of activating transcription factor 4 (ATF4), p75 neurotrophin receptor (p75NTR), and interleukin 8 (IL-8) was greatly increased in SFO-induced EndoMT. Knockdown of ATF4 inhibited the SFO-induced EndoMT completely, and knockdown of p75NTR or IL-8 partially inhibited the EndoMT, which suggests that all three factors were involved in the process. Furthermore, knockdown of p75NTR inhibited the SFO-increased IL-8 expression and secretion, and knockdown of ATF4 inhibited SFO-increased p75NTR level significantly. The ATF4/p75NTR/IL-8 signal pathway may have an important role in EndoMT induced by SFO. Our findings support potential novel targets for the therapeutics of cancer and fibrosis disease. PMID:24905361

  11. Finding ATF4/p75NTR/IL-8 signal pathway in endothelial-mesenchymal transition by safrole oxide.

    Directory of Open Access Journals (Sweden)

    Di Ge

    Full Text Available Targeting the endothelial-to-mesenchymal transition (EndoMT may be a novel therapeutic strategy for cancer and various diseases induced by fibrosis. We aimed to identify a small chemical molecule as an inducer of EndoMT and find a new signal pathway by using the inducer. Safrole oxide (SFO, 50 µg/ml, could most effectively induce EndoMT within 12 h. To understand the underlying molecular mechanism, we performed microarray, quantitative real-time PCR and western blot analysis to find key factors involved in SFO-induced EndoMT and demonstrated the involvement of the factors by RNAi. The expression of activating transcription factor 4 (ATF4, p75 neurotrophin receptor (p75NTR, and interleukin 8 (IL-8 was greatly increased in SFO-induced EndoMT. Knockdown of ATF4 inhibited the SFO-induced EndoMT completely, and knockdown of p75NTR or IL-8 partially inhibited the EndoMT, which suggests that all three factors were involved in the process. Furthermore, knockdown of p75NTR inhibited the SFO-increased IL-8 expression and secretion, and knockdown of ATF4 inhibited SFO-increased p75NTR level significantly. The ATF4/p75NTR/IL-8 signal pathway may have an important role in EndoMT induced by SFO. Our findings support potential novel targets for the therapeutics of cancer and fibrosis disease.

  12. Finding ATF4/p75NTR/IL-8 signal pathway in endothelial-mesenchymal transition by safrole oxide.

    Science.gov (United States)

    Ge, Di; Jing, Qingchuan; Zhao, Wenbo; Yue, Hongwei; Su, Le; Zhang, ShangLi; Zhao, Jing

    2014-01-01

    Targeting the endothelial-to-mesenchymal transition (EndoMT) may be a novel therapeutic strategy for cancer and various diseases induced by fibrosis. We aimed to identify a small chemical molecule as an inducer of EndoMT and find a new signal pathway by using the inducer. Safrole oxide (SFO), 50 µg/ml, could most effectively induce EndoMT within 12 h. To understand the underlying molecular mechanism, we performed microarray, quantitative real-time PCR and western blot analysis to find key factors involved in SFO-induced EndoMT and demonstrated the involvement of the factors by RNAi. The expression of activating transcription factor 4 (ATF4), p75 neurotrophin receptor (p75NTR), and interleukin 8 (IL-8) was greatly increased in SFO-induced EndoMT. Knockdown of ATF4 inhibited the SFO-induced EndoMT completely, and knockdown of p75NTR or IL-8 partially inhibited the EndoMT, which suggests that all three factors were involved in the process. Furthermore, knockdown of p75NTR inhibited the SFO-increased IL-8 expression and secretion, and knockdown of ATF4 inhibited SFO-increased p75NTR level significantly. The ATF4/p75NTR/IL-8 signal pathway may have an important role in EndoMT induced by SFO. Our findings support potential novel targets for the therapeutics of cancer and fibrosis disease.

  13. MiR-214 regulates the function of osteoblast under simulated microgravity by targeting ATF4

    Science.gov (United States)

    Li, Yingxian; Wang, Xiaogang; Li, Qi; Lv, Ke; Wan, Yumin; Li, Yinghui; Bai, Yanqiang

    Background: MicroRNAs (miRNAs) are small fragments of single-stranded RNA containing 18-24 nucleotides, and are generated from endogenous transcripts. MicroRNAs function in post-transcriptional gene silencing by targeting the 3'-untranslated region (UTR) of mRNAs, resulting in translational repression. Growing evidence shows that microRNAs (miRNAs) regu-late various developmental and homeostatic events in vertebrates and invertebrates. Osteoblast differentiation is a key step in proper skeletal development and acquisition of bone mass; How-ever, the physiological role of non-coding small RNAs, especially miRNAs, in osteoblast dif-ferentiation remains elusive. Methods: To study the potential involvement of miRNAs in osteoblast differentiation under stimulated microgravity, we analyzed the expression of 20 bone relative miRNAs using real time PCR platform to find particularly miRNAs whose expression is altered during osteoblast differentiation. TargetScan, miRBase and Miranda were used to predict the target gene of candidate miRNA. To investigate whether ATF4 can be directly targeted by miR-214, we engineered luciferase reporters that have either the wild-type 3'UTRs of these genes, or the mutant UTRs with a 6 base pair (bp) deletion in the target sites. Lastly, to address the in vivo role of miR-214 in bone formation, tail suspension mice model was used to simulate the change of osteoblast function and bone loss. Results: Recent studies have sug-gested that miRNAs might play a role in osteoblast differentiation and bone formation. Here, we identify miR-214 in MC3T3-E1 cells, which is a primary mouse osteoblasts cell line, to promote osteoblast differentiation by repressing Activating Transcription Factor4 (ATF4) ex-pression at the posttranscriptional level. What is more, miR-214 was found to be transcribed in C2C12 cells during bone morphogenetic protein 2-induced (BMP2-induced) osteogenesis, and overexpression of miR-214 attenuated BMP2-induced osteoblastogenesis

  14. MICRON-SCALE LASER-WIRE AT THE ATF-II AT KEK COMMISSIONING AND RESULTS

    CERN Document Server

    Nevay, L J; Walczak, R; Blair, G A; Boogert, S; Deacon, L C; Karataev, P; Aryshev, A; Terunuma, N; Urakawa, J

    2011-01-01

    We present the first results from the commissioning of the upgraded laser-wire experiment at the Accelerator Test Facility 2 (ATF-II) at KEK. A new laser transport line and beam diagnostics were used to collide 150 mJ, 167 ps long laser pulses with 1.28 GeV, 30 ps long electron bunches to measure the vertical transverse size. Additionally, a new detector was installed with a reduced area for lower background. Initial scans showing a convoluted beam size of 18.4 ± 0.4 μm were used to tune the electron beam optics and reduce this down to 8.0 ± 0.3 μm. Laser pulse energy and charge dependency were investigated showing a linear relationship in both with a minimum laser energy of 20 mJ required for adequate signal to make a laser-wire scan.

  15. Experiment studies on the polarized gamma-rays generation at KEK-ATF

    Institute of Scientific and Technical Information of China (English)

    LI Xiao-Ping; PEI Guo-Xi

    2009-01-01

    Polarized positrons can be created through electron-positron pair creation from circularly polarized gamma-rays. Laser-Compton scattering is an efficient method to generate circularly polarized gamma-rays. A high finesse 2-mirror optical stacking cavity had been installed on the straight section of the electron storage ring at KEK-ATF. A 1064 nm circularly polarized pulsed laser beam was stacked in the cavity. Polarized gamma-rays with a maximum energy of 28.3 MeV were produced via inverse Compton scattering of the enhanced laser pulse off an electron beam of 1.28 GeV. The number of generated gamma photons per collision was estimated by a photon detector. It was found that the experimental result was in agreement with the simulated value.

  16. DESIGN AND PERFORMANCE OF INTRA-TRAIN FEEDBACK SYSTEMS AT ATF2

    CERN Document Server

    Resta-Lopez, J

    2009-01-01

    The major goals of the final focus test beam line facility ATF2 are to provide electron beams with a few tens of nanometer beam sizes and beam stability control at the nanometer level. In order to achieve such a level of stability beam-based feedback systems are necessary at different timescales to correct static and dynamic effects. In particular, we present the design of intra-train feedback systems to correct the impact of fast jitter sources. We study a bunchto- bunch feedback system installed in the extraction line to combat the ring extraction transverse jitters. In addition, we design a bunch-to-bunch feedback system at the interaction point for correction of position jitter due to the fast vibration of the magnets in the final focus. Optimum feedback software algorithms are discussed and simulation results are presented.

  17. Measured Thermal and Fast Neutron Fluence Rates for ATF-1 Holders During ATR Cycle 157D

    Energy Technology Data Exchange (ETDEWEB)

    Smith, Larry Don [Idaho National Lab. (INL), Idaho Falls, ID (United States); Miller, David Torbet [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2016-03-01

    This report contains the thermal (2200 m/s) and fast (E>1MeV) neutron fluence rate data for the ATF-1 holders located in core for ATR Cycle 157D which were measured by the Radiation Measurements Laboratory (RML) as requested by the Power Reactor Programs (ATR Experiments) Radiation Measurements Work Order. This report contains measurements of the fluence rates corresponding to the particular elevations relative to the 80-ft. core elevation. The data in this report consist of (1) a table of the ATR power history and distribution, (2) a hard copy listing of all thermal and fast neutron fluence rates, and (3) plots of both the thermal and fast neutron fluence rates. The fluence rates reported are for the average power levels given in the table of power history and distribution.

  18. Toroidal cell and battery. [storage battery for high amp-hour load applications

    Science.gov (United States)

    Nagle, W. J. (Inventor)

    1981-01-01

    A toroidal storage battery designed to handle relatively high amp-hour loads is described. The cell includes a wound core disposed within a pair of toroidal channel shaped electrodes spaced apart by nylon insulator. The shape of the case electrodes of this toroidal cell allows a first planar doughnut shaped surface and the inner cylindrical case wall to be used as a first electrode and a second planar doughnut shaped surface and the outer cylindrical case wall to be used as a second electrode. Connectors may be used to stack two or more toroidal cells together by connecting substantially the entire surface area of the first electrode of a first cell to substantially the entire surface area of the second electrode of a second cell. The central cavity of each toroidal cell may be used as a conduit for pumping a fluid through the toroidal cell to thereby cool the cell.

  19. PARTICLE-HOLE NATURE OF THE LIGHT HIGH-SPIN TOROIDAL ISOMERS

    Energy Technology Data Exchange (ETDEWEB)

    Staszczak, A. [Maria Curie-Sklodowska University, Poland; Wong, Cheuk-Yin [ORNL

    2015-01-01

    Nuclei under non-collective rotation with a large angular momentum above some threshold can assume a toroidal shape. In our previous work, we showed by using cranked Skyrme Hartree Fock approach that even even, N = Z, high-K, toroidal isomeric states may have general occurrences for light nuclei with 28 < A < 52. We present here some additional results and systematics on the particle-hole nature of these high-spin toroidal isomers.

  20. The comparative analysis of the different mechanisms of toroidal rotation in tokamaks

    Energy Technology Data Exchange (ETDEWEB)

    Sabot, R. [Association Euratom-CEA, Centre d`Etudes Nucleaires de Cadarache, 13 - Saint-Paul-lez-Durance (France). Dept. de Recherches sur la Fusion Controlee; Parail, V. [Kurchatov Institute, Moscow (Russian Federation)

    1994-07-01

    The toroidal plasma rotation appears as one the possible mechanism for suppression of plasma turbulence. Several mechanisms are believed to contribute to the toroidal plasma rotation. The results of numerical simulation of the toroidal rotation on JET are presented, where are taken into consideration the following effects: the neoclassical viscosity due to banana and ripple trapped particles, the anomalous viscosity due to plasma turbulence, the momentum input by NBI (neutron beam injection) and ion momentum loss near the separatrix due to prompt ion losses. The NBI appeared to be the principal source of toroidal plasma rotation. 6 refs., 2 figs.

  1. D{sup -} energy spectrum in toroidal quantum ring

    Energy Technology Data Exchange (ETDEWEB)

    Gomez, C A; Gutierrez, W; Garcia, L F [Universidad Industrial de Santander, Bucaramanga (Colombia); Marin, J H, E-mail: jhmarin@unal.edu.c [Universidad Nacional-Colombia, Medellin-Colombia, AA3840 (Colombia)

    2009-05-01

    The structure of energy spectrum of the negative donor centre in a toroidal-shaped quantum ring with two different morphologies of the cross-section is analyzed. By using the adiabatic procedure we have deduced a one-dimensional wave equation with periodic conditions which describes the low-lying energy levels related to the electrons rotation around the symmetry axis. Our results are in good agreement with those previously obtained as the size of the ring cross-section tends to zero.

  2. Experimental observation of crystalline particle flows in toroidal dust clouds

    Energy Technology Data Exchange (ETDEWEB)

    Wilms, Jochen, E-mail: wilms@physik.uni-kiel.de; Piel, Alexander [IEAP, Christian-Albrechts-Universität, D-24098 Kiel (Germany); Reichstein, Torben [IEAP, Christian-Albrechts-Universität, D-24098 Kiel (Germany); DME, Kiel University of Applied Sciences, Grenzstr. 3, D-24147 Kiel (Germany)

    2015-06-15

    The dust flow in a toroidal dust trap is studied experimentally. The flow is driven by the Hall component of the ion drag force in a magnetized plasma. Dust density waves are found in a torus with a large minor radius a, which allows for several wavelength, 2a>5λ, in the (mostly) radial direction of the ion flow. Beyond an intermediate state with radial sloshing oscillations, a crystalline dust flow with suppressed wave activity could be realized for 2a<2λ. The particles arrange themselves in distinct layers with hexagonal-like local order. Smooth transitions between states with different numbers of layers are found in the inhomogeneous flow.

  3. Simulation of dust streaming in toroidal traps: Stationary flows

    Energy Technology Data Exchange (ETDEWEB)

    Reichstein, Torben; Piel, Alexander [IEAP, Christian-Albrechts-Universitaet, D-24098 Kiel (Germany)

    2011-08-15

    Molecular-dynamic simulations were performed to study dust motion in a toroidal trap under the influence of the ion drag force driven by a Hall motion of the ions in E x B direction, gravity, inter-particle forces, and friction with the neutral gas. This article is focused on the inhomogeneous stationary streaming motion. Depending on the strength of friction, the spontaneous formation of a stationary shock or a spatial bifurcation into a fast flow and a slow vortex flow is observed. In the quiescent streaming region, the particle flow features a shell structure which undergoes a structural phase transition along the flow direction.

  4. Stationary motion of a self gravitating toroidal incompressible liquid layer

    CERN Document Server

    Fusco, Giorgio; Oliva, Waldyr M

    2012-01-01

    We consider an incompressible fluid contained in a toroidal stratum which is only subjected to Newtonian self-attraction. Under the assumption of infinitesimal tickness of the stratum we show the existence of stationary motions during which the stratum is approximatly a round torus (with radii r, R and R>>r) that rotates around its axis and at the same time rolls on itself. Therefore each particle of the stratum describes an helix-like trajectory around the circumference of radius R that connects the centers of the cross sections of the torus.

  5. Total and paired domination numbers of toroidal meshes

    CERN Document Server

    Hu, Fu-Tao

    2011-01-01

    Let $G$ be a graph without isolated vertices. The total domination number of $G$ is the minimum number of vertices that can dominate all vertices in $G$, and the paired domination number of $G$ is the minimum number of vertices in a dominating set whose induced subgraph contains a perfect matching. This paper determines the total domination number and the paired domination number of the toroidal meshes, i.e., the Cartesian product of two cycles $C_n$ and $C_m$ for any $n\\ge 3$ and $m\\in\\{3,4\\}$, and gives some upper bounds for $n, m\\ge 5$.

  6. Fabrication of toroidal composite pressure vessels. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Dodge, W.G.; Escalona, A.

    1996-11-24

    A method for fabricating composite pressure vessels having toroidal geometry was evaluated. Eight units were fabricated using fibrous graphite material wrapped over a thin-walled aluminum liner. The material was wrapped using a machine designed for wrapping, the graphite material was impregnated with an epoxy resin that was subsequently thermally cured. The units were fabricated using various winding patterns. They were hydrostatically tested to determine their performance. The method of fabrication was demonstrated. However, the improvement in performance to weight ratio over that obtainable by an all metal vessel probably does not justify the extra cost of fabrication.

  7. Position indicating split toroid for the RACE experiment

    Energy Technology Data Exchange (ETDEWEB)

    Hurst, B. [Nuclear Engineering Teaching Laboratory, University of Texas, 10100 Burnet Road, Austin, TX 78758 (United States)]. E-mail: bhurst@mail.utexas.edu; Folkman, K. [Idaho Accelerator Center, Idaho State University, Pocatello, ID 83201 (United States)

    2007-08-15

    Aspects of the recent reactor accelerator coupled experiments (RACE) carried out at University of Texas Nuclear Engineering Teaching Laboratory will be discussed. In particular, a compact instrument that allowed a continuous non-invasive means of determining the relative electron beam position was developed. The operation of the instrument is similar to an inductive current pick up toroid except that the core is sectioned radially, which allows spatial information to be derived from the induced voltages. Results of initial tests, both in beam and with a pulser, will be presented along with plans to optimize future designs.

  8. Toroidal equilibrium with low frequency wave driven currents

    Energy Technology Data Exchange (ETDEWEB)

    Ehst, D.A.

    1984-12-01

    In the absence of an emf the parallel current, j/sub parallel/, in a steady state tokamak will consist of a neoclassical portion plus a wave-driven contribution. Using the drift kinetic equation, the quasilinear (wave-driven) current is computed for high phase speed waves in a torus, and this is combined with the neoclassical term to obtain the general expression for the flux surface average . For a given pressure profile this technique fully determines the MHD equilibrium, permitting the study of a new class of toroidal equilibria.

  9. Resistive demountable toroidal-field coils for tokamak reactors

    Energy Technology Data Exchange (ETDEWEB)

    Jassby, D.L.; Jacobsen, R.A.; Kalnavarns, J.; Masson, L.S.; Sekot, J.P.

    1981-07-01

    Readily demountable TF (toroidal-field) coils allow complete access to the internal components of a tokamak reactor for maintenance of replacement. The requirement of readily demountable joints dictates the use of water-cooled resistive coils, which have a host of decisive advantages over superconducting coils. Previous papers have shown that resistive TF coils for tokamak reactors can operate in the steady state with acceptable power dissipation (typically, 175 to 300 MW). This paper summarizes results of parametric studies of size optimization of rectangular TF coils and of a finite-element stress analysis, and examines several candidate methods of implementing demountable joints for rectangular coils constructed of plate segments.

  10. Members of the CREB/ATF and AP1 family of transcription factors are involved in the regulation of SOX18 gene expression

    Directory of Open Access Journals (Sweden)

    Petrović Isidora

    2011-01-01

    Full Text Available The SOX18 transcription factor plays an important role in endothelial cell specification, angiogenesis and atherogenesis. By profiling transcription factor interactions (TranSignal TM TF Protein Array we identified several transcription factors implicated in angiogenesis that have the ability to bind to the SOX18 optimal promoter region in vitro. In this report we focused our attention on distinct transcription factors identified by the array as belonging to AP-1 and CREB/ATF protein families. In particular, we analyzed the effects of CREB, JunB, c-Jun and ATF3 on SOX18 gene expression. Functional analysis revealed that CREB acts as a repressor, while JunB, c-Jun and ATF3 act as activators of SOX18 promoter activity. Our findings indicate that a transcriptional network that includes CREB, JunB, c-Jun and ATF3 could be involved in angiogenesis-related transcriptional regulation of the SOX18 gene.

  11. Toroidal modelling of RMP response in ASDEX Upgrade: coil phase scan, q 95 dependence, and toroidal torques

    Science.gov (United States)

    Liu, Yueqiang; Ryan, D.; Kirk, A.; Li, Li; Suttrop, W.; Dunne, M.; Fischer, R.; Fuchs, J. C.; Kurzan, B.; Piovesan, P.; Willensdorfer, M.; the ASDEX Upgrade Team; the EUROfusion MST1 Team

    2016-05-01

    The plasma response to the vacuum resonant magnetic perturbation (RMP) fields, produced by the ELM control coils in ASDEX Upgrade experiments, is computationally modelled using the MARS-F/K codes (Liu et al 2000 Phys. Plasmas 7 3681, Liu et al 2008 Phys. Plasmas 15 112503). A systematic investigation is carried out, considering various plasma and coil configurations as in the ELM control experiments. The low q plasmas, with {{q}95}˜ 3.8 (q 95 is the safety factor q value at 95% of the equilibrium poloidal flux), responding to low n (n is the toroidal mode number) field perturbations from each single row of the ELM coils, generates a core kink amplification effect. Combining two rows, with different toroidal phasing, thus leads to either cancellation or reinforcement of the core kink response, which in turn determines the poloidal location of the peak plasma surface displacement. The core kink response is typically weak for the n  =  4 coil configuration at low q, and for the n  =  2 configuration but only at high q ({{q}95}˜ 5.5 ). A phase shift of around 60 degrees for low q plasmas, and around 90 degrees for high q plasmas, is found in the coil phasing, between the plasma response field and the vacuum RMP field, that maximizes the edge resonant field component. This leads to an optimal coil phasing of about 100 (-100) degrees for low (high) q plasmas, that maximizes both the edge resonant field component and the plasma surface displacement near the X-point of the separatrix. This optimal phasing closely corresponds to the best ELM mitigation observed in experiments. A strong parallel sound wave damping moderately reduces the core kink response but has minor effect on the edge peeling response. For low q plasmas, modelling shows that both the resonant electromagnetic torque and the neoclassical toroidal viscous (NTV) torque (due to the presence of 3D magnetic field perturbations) contribute to the toroidal flow damping, in particular near the

  12. Inversion of the Abel equation for toroidal density distributions

    CERN Document Server

    Ciotti, L

    1999-01-01

    In this paper I present three new results of astronomical interest concerning the theory of Abel inversion. 1) I show that in the case of a spatial emissivity that is constant on toroidal surfaces and projected along the symmetry axis perpendicular to the torus' equatorial plane, it is possible to invert the projection integral. From the surface (i.e. projected) brightness profile one then formally recovers the original spatial distribution as a function of the toroidal radius. 2) By applying the above-described inversion formula, I show that if the projected profile is described by a truncated off-center gaussian, the functional form of the related spatial emissivity is very simple and - most important - nowhere negative for any value of the gaussian parameters, a property which is not guaranteed - in general - by Abel inversion. 3) Finally, I show how a generic multimodal centrally symmetric brightness distribution can be deprojected using a sum of truncated off-center gaussians, recovering the spatial emis...

  13. Last End Cap Toroid installation : The Pharaonic enterprise

    CERN Multimedia

    Arnaud Foussat

    After the successful and impressive transport feat from Building 191 to Point 1 was carried out by the Friderici crew on 28th June, the second and last Toroid End Cap, ECT-C, was transferred into the surface building, SX1, on 2nd July. The ECT-C was installed in the ATLAS cavern on the C-side on 12th July. As the person responsible for the project, in my opinion, one of the crucial points of this project was to design all the tooling and installation sequences taking into account the building infrastructure dimensional constraints. View of the ECT installation tooling and preparation for the ECT-C descent into the ATLAS 80m-shaft by the ATLAS magnet group and DBS teams. The movement of the 240-ton magnet and 12-m diameter toroid end-cap was achieved in collaboration with SCALES, a subcontractor company, using a hydraulic gantry able to lower the ECT inside the shaft by 5m below the floor level . This allowed the DBS team to attach the end-cap with the 2 x 140 tons overhead crane and lower it onto the c...

  14. Baryonic torii: Toroidal baryons in a generalized Skyrme model

    Science.gov (United States)

    Gudnason, Sven Bjarke; Nitta, Muneto

    2015-02-01

    We study a Skyrme-type model with a potential term motivated by Bose-Einstein condensates (BECs), which we call the BEC Skyrme model. We consider two flavors of the model: the first is the Skyrme model, and the second has a sixth-order derivative term instead of the Skyrme term, both with the added BEC-motivated potential. The model contains toroidally shaped Skyrmions, and they are characterized by two integers P and Q , representing the winding numbers of two complex scalar fields along the toroidal and poloidal cycles of the torus, respectively. The baryon number is B =P Q . We find stable Skyrmion solutions for P =1 ,2 ,3 ,4 ,5 with Q =1 , while for P =6 and Q =1 , it is only metastable. We further find that configurations with higher Q >1 are all unstable and split into Q configurations with Q =1 . Finally we discover a phase transition, possibly of first order, in the mass parameter of the potential under study.

  15. Cryogenic Characteristics of the ATLAS Barrel Toroid Superconducting Magnet

    CERN Document Server

    Pengo, R; Delruelle, N; Pezzetti, M; Pirotte, O; Passardi, Giorgio; Dudarev, A; ten Kate, H

    2008-01-01

    ATLAS, one of the experiments of the LHC accelerator under commissioning at CERN, is equipped with a large superconducting magnet the Barrel Toroid (BT) that has been tested at nominal current (20500 A). The BT is composed of eight race-track superconducting coils (each one weights about 45 tons) forming the biggest air core toroidal magnet ever built. By means of a large throughput centrifugal pump, a forced flow (about 10 liter/second at 4.5 K) provides the indirect cooling of the coils in parallel. The paper describes the results of the measurements carried out on the complete cryogenic system assembled in the ATLAS cavern situated 100 m below the ground level. The measurements include, among other ones, the static heat loads, i.e., with no or constant current in the magnet, and the dynamic ones, since additional heat losses are produced, during the current ramp-up or slow dump, by eddy currents induced on the coil casing.

  16. Instability of toroidal magnetic field in jets and plerions

    CERN Document Server

    Begelman, M C

    1997-01-01

    Jets and pulsar-fed supernova remnants (plerions) tend to develop highly organized toroidal magnetic field. Such a field structure could explain the polarization properties of some jets, and contribute to their lateral confinement. A toroidal field geometry is also central to models for the Crab Nebula - the archetypal plerion - and leads to the deduction that the Crab pulsar's wind must have a weak magnetic field. Yet this `Z-pinch' field configuration is well known to be locally unstable, even when the magnetic field is weak and/or boundary conditions slow or suppress global modes. Thus, the magnetic field structures imputed to the interiors of jets and plerions are unlikely to persist. To demonstrate this, I present a local analysis of Z-pinch instabilities for relativistic fluids in the ideal MHD limit. Kink instabilities dominate, destroying the concentric field structure and probably driving the system toward a more chaotic state in which the mean field strength is independent of radius (and in which re...

  17. Calculation of modification to the toroidal magnetic field of the Tokamak Novillo. Part II; Calculo de modificacion al campo magnetico toroidal del Tokamak nivillo. Parte II

    Energy Technology Data Exchange (ETDEWEB)

    Melendez L, L.; Chavez A, E.; Colunga S, S.; Valencia A, R.; Lopez C, R.; Gaytan G, E

    1992-03-15

    In a cylindrical magnetic topology. the confined plasma experiences 'classic' collisional transport phenomena. When bending the cylinder with the purpose of forming a toro, the magnetic field that before was uniform now it has a radial gradient which produces an unbalance in the magnetic pressure that is exercised on the plasma in the transverse section of the toro. This gives place to transport phenomena call 'neo-classicist'. In this work the structure of the toroidal magnetic field produced by toroidal coils of triangular form, to which are added even of coils of compensation with form of half moon is analyzed. With this type of coils it is looked for to minimize the radial gradient of the toroidal magnetic field. The values and characteristics of B (magnetic field) in perpendicular planes to the toro in different angular positions in the toroidal direction, looking for to cover all the cases of importance are exhibited. (Author)

  18. The Yeast ATF1 Acetyltransferase Efficiently Acetylates Insect Pheromone Alcohols: Implications for the Biological Production of Moth Pheromones.

    Science.gov (United States)

    Ding, Bao-Jian; Lager, Ida; Bansal, Sunil; Durrett, Timothy P; Stymne, Sten; Löfstedt, Christer

    2016-04-01

    Many moth pheromones are composed of mixtures of acetates of long-chain (≥10 carbon) fatty alcohols. Moth pheromone precursors such as fatty acids and fatty alcohols can be produced in yeast by the heterologous expression of genes involved in insect pheromone production. Acetyltransferases that subsequently catalyze the formation of acetates by transfer of the acetate unit from acetyl-CoA to a fatty alcohol have been postulated in pheromone biosynthesis. However, so far no fatty alcohol acetyltransferases responsible for the production of straight chain alkyl acetate pheromone components in insects have been identified. In search for a non-insect acetyltransferase alternative, we expressed a plant-derived diacylglycerol acetyltransferase (EaDAcT) (EC 2.3.1.20) cloned from the seed of the burning bush (Euonymus alatus) in a yeast system. EaDAcT transformed various fatty alcohol insect pheromone precursors into acetates but we also found high background acetylation activities. Only one enzyme in yeast was shown to be responsible for the majority of that background activity, the acetyltransferase ATF1 (EC 2.3.1.84). We further investigated the usefulness of ATF1 for the conversion of moth pheromone alcohols into acetates in comparison with Ea DAcT. Overexpression of ATF1 revealed that it was capable of acetylating these fatty alcohols with chain lengths from 10 to 18 carbons with up to 27- and 10-fold higher in vivo and in vitro efficiency, respectively, compared to Ea DAcT. The ATF1 enzyme thus has the potential to serve as the missing enzyme in the reconstruction of the biosynthetic pathway of insect acetate pheromones from precursor fatty acids in yeast.

  19. Interplay of CREB and ATF2 in Ionizing Radiation-Induced Neuroendocrine Differentiation of Prostate Cancer Cells

    Science.gov (United States)

    2012-06-01

    cross-talk between Hh and androgen signaling in prostate cancer. Source of Funding: NCI RO1-CA111618; DOD W81XWH-06 377 WHAT CAN THE HAIR FOLLICLES ...demonstrated that targeting CREB signaling can increase IR-induced cell death. We also demonstrated that IR induces NED in xenograft nude mouse models and in...heterodimer to regulate gene transcription [21]. While some target genes can be activated by CREB and ATF2 equally or cooperatively [22-24

  20. Letter Report Documenting Progress of Second Generation ATF FeCrAl Alloy Fabrication

    Energy Technology Data Exchange (ETDEWEB)

    Yamamoto, Y. [ORNL; Yang, Y. [ORNL; Field, K. G. [ORNL; Terrani, K. [ORNL; Pint, B. A. [ORNL; Snead, L. L. [ORNL

    2014-06-10

    Development of the 2nd generation ATF FeCrAl alloy has been initiated, and a candidate alloy was selected for trial tube fabrication through hot-extrusion and gun-drilling processes. Four alloys based on Fe-13Cr-4.5Al-0.15Y in weight percent were newly cast with minor alloying additions of Mo, Si, Nb, and C to promote solid-solution and second-phase precipitate strengthening. The alloy compositions were selected with guidance from computational thermodynamic tools. The lab-scale heats of ~ 600g were arc-melted and drop-cast, homogenized, hot-forged and -rolled, and then annealed producing plate shape samples. An alloy with Mo and Nb additions (C35MN) processed at 800°C exhibits very fine sub-grain structure with the sub-grain size of 1-3μm which exhibited more than 25% better yield and tensile strengths together with decent ductility compared to the other FeCrAl alloys at room temperature. It was found that the Nb addition was key to improving thermal stability of the fine sub-grain structure. Optimally, grains of less than 30 microns are desired, with grains up to and order of magnitude in desired produced through Nb addition. Scale-up effort of the C35MN alloy was made in collaboration with a commercial cast company who has a capability of vacuum induction melting. A 39lb columnar ingot with ~81mm diameter and ~305mm height (with hot-top) was commercially cast, homogenized, hot-extruded, and annealed providing 10mm-diameter bar-shape samples with the fine sub-grain structure. This commercial heat proved consistent with materials produced at ORNL at the lab-scale. Tubes and end caps were machined from the bar sample and provided to another work package for the ATF-1 irradiation campaign in the milestone M3FT-14OR0202251.

  1. Investigation of toroidal acceleration and potential acceleration forces in EAST and J-TEXT plasmas

    CERN Document Server

    Wang, Fudi; Pan, Xiayun; Cheng, Zhifeng; Chen, Jun; Cao, Guangming; Wang, Yuming; Han, Xiang; Li, Hao; Wu, Bin; Chen, Zhongyong; Bitter, Manfred; Hill, Kenneth; Rice, John; Morita, Shigeru; Li, Yadong; Zhuang, Ge; Ye, Minyou; Wan, Baonian; Shi, Yuejiang

    2014-01-01

    In order to produce intrinsic rotation, bulk plasmas must be collectively accelerated by the net force exerted on them, which results from both driving and damping forces. So, to study the possible mechanisms of intrinsic rotation generation, it is only needed to understand characteristics of driving and damping terms because the toroidal driving and damping forces induce net acceleration which generates intrinsic rotation. Experiments were performed on EAST and J-TEXT for ohmic plasmas with net counter- and co-current toroidal acceleration generated by density ramping up and ramping down. Additionally on EAST, net co-current toroidal acceleration was also formed by LHCD or ICRF. For the current experimental results, toroidal acceleration was between - 50 km/s^2 in counter-current direction and 70 km/s^2 in co-current direction. According to toroidal momentum equation, toroidal electric field (E\\-(\\g(f))), electron-ion toroidal friction, and toroidal viscous force etc. may play roles in the evolution of toroi...

  2. Geodesic Acoustic Mode in Toroidally Axisymmetric Plasmas with Non-Circular Cross Sections

    Institute of Scientific and Technical Information of China (English)

    SHI Bing-Ren; LI Ji-Quan; DONG Jia-Qi

    2005-01-01

    @@ The geodesic acoustic mode in general toroidally axisymmetric plasmas such as Tokamak and spherical torus is studied in detail. The mode structure is found and the dispersion equation is derived and solved for arbitrary toroidally axi-symmetric plasmas. Besides the finite aspect ratio, effects of elongation and triangularity on this mode are clarified.

  3. A Project to Design and Build the Magnets for a New Test Beamline, the ATF2, at KEK

    Energy Technology Data Exchange (ETDEWEB)

    Spencer, Cherrill M.; /slac; Sugahara, Ryuhei; Masuzawa, Mika; /KEK, Tsukuba; Bolzon, Benoit; Jeremie, Andrea; /Annecy, LAPP

    2011-02-07

    In order to achieve the high luminosity required at the proposed International Linear Collider (ILC), it is critical to focus the beams to nanometer size with the ILC Beam Delivery System, and to maintain the beams collisions with a nanometer-scale stability. To establish the technologies associated with this ultra-high precision beam handling, a special beamline has been designed and built as an extension of the existing extraction beamline of the Accelerator Test Facility at KEK, Japan. The ATF provides an adequate ultra-low emittance electron beam that is comparable to the ILC requirements; the ATF2 mimics the ILC final focus system to create a tightly focused, stable beam. There are 37 magnets in the ATF2, 29 quadrupoles, 5 sextupoles and 3 bends. These magnets had to be acquired in a short time and at minimum cost, which led to various acquisition strategies; but nevertheless they had to meet strict requirements on integrated strength, physical dimensions, compatibility with existing magnet movers and beam position monitors, mechanical stability and field stability and quality. This paper will describe how 2 styles of quadrupoles, 2 styles of sextupoles, one dipole style and their supports were designed, fabricated, refurbished or modified, measured and aligned by a small team of engineers from 3 continents.

  4. The Experiment of Modulated Toroidal Current on HT-7 and HT-6M Tokamak

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    The Experiments of Modulated Toroidal Current were done on the HT-6M tokamakand HT-7 superconducting tokamak. The toroidal current was modulated by programming theOhmic heating field. Modulation of the plasma current has been used successfully to suppressMHD activity in discharges near the density limit where large MHD m = 2 tearing modes weresuppressed by sufficiently large plasma current oscillations. The improved Ohmic confinementphase was observed during modulating toroidal current (MTC) on the Hefei Tokamak-6M (HT-6M) and Hefei superconducting Tokamak-7 (HT-7). A toroidal frequency-modulated current,induced by a modulated loop voltage, was added on the plasma equilibrium current. The ratio ofA.C. amplitude of plasma current to the main plasma current △Ip/Ip is about 12% ~ 30%. Thedifferent formats of the frequency-modulated toroidal current were compared.

  5. Modulating toroidal flow stabilization of edge localized modes with plasma density

    CERN Document Server

    Cheng, Shikui; Banerjee, Debabrata

    2016-01-01

    Recent EAST experiments have demonstrated mitigation and suppression of edge localized modes (ELMs) with toroidal rotation flow in higher collisionality regime, suggesting potential roles of plasma density. In this work, the effects of plasma density on the toroidal flow stabilization of the high-$n$ edge localized modes have been extensively studied in linear calculations for a circular-shaped limiter H-mode tokamak, using the extended MHD code NIMROD. In the single MHD model, toroidal flow has a weak stabilizing effects on the high-$n$ modes. Such a stabilization, however, can be significantly enhanced with the increase in plasma density. Furthermore, our calculations show that the enhanced stabilization of high-$n$ modes from toroidal flow with higher edge plasma density persists in the 2-fluid MHD model. These findings may explain the ELM mitigation and suppression by toroidal rotation in higher collisionality regime due to the enhancement of plasma density obtained in recent EAST experiments.

  6. Toroidally Asymmetric Distributions of Hydrocarbon (CD) Emission and Chemical Sputtering Sources in DIII-D

    Energy Technology Data Exchange (ETDEWEB)

    Groth, M; Brooks, N H; Fenstermacher, M E; Lasnier, C J; McLean, A G; Watkins, J G

    2006-05-16

    Measurements in DIII-D show that the carbon chemical sputtering sources along the inner divertor and center post are toroidally periodic and highest at the upstream tile edge. Imaging with a tangentially viewing camera and visible spectroscopy were used to monitor the emission from molecular hydrocarbons (CH/CD) at 430.8 nm and deuterium neutrals in attached and partially detached divertors of low-confinement mode plasmas. In contrast to the toroidally periodic CD distribution, emission from deuterium neutrals was observed to be toroidally symmetric along the inner strike zone. The toroidal distribution of the measured tile surface temperature in the inner divertor correlates with that of the CD emission, suggesting larger parallel particle and heat fluxes to the upstream tile edge, either due to toroidal tile gaps or height steps between adjacent tiles.

  7. Toroidal high-spin isomers in light nuclei with N not equal to Z

    CERN Document Server

    Staszczak, Andrzej

    2014-01-01

    The combined considerations of both the bulk liquid-drop-type behavior and the quantized aligned rotation with cranked Skyrme-Hartree-Fock approach revealed previously that even-even, N=Z, toroidal high-spin isomeric states have general occurrences for light nuclei with A between 28 and 52. We find that in this mass region there are in addition N not equal to Z toroidal high-spin isomers when the single-particle shells for neutrons and protons occur at the same cranked frequency $\\hbar \\omega$. Examples of N not equal to Z toroidal high-spin isomers, $^{36}_{16}$S$_{20}$($I$=74$\\hbar$) and $^{40}_{18}$Ar$_{22}$($I$=80,102$\\hbar$), are located and examined. The systematic properties of these N not equal to Z toroidal high-spin isomers fall into the same regular (muti-particle)-(muti-hole) patterns as other N=Z toroidal high-spin isomers.

  8. 3D toroidal physics: testing the boundaries of symmetry breaking

    Science.gov (United States)

    Spong, Don

    2014-10-01

    Toroidal symmetry is an important concept for plasma confinement; it allows the existence of nested flux surface MHD equilibria and conserved invariants for particle motion. However, perfect symmetry is unachievable in realistic toroidal plasma devices. For example, tokamaks have toroidal ripple due to discrete field coils, optimized stellarators do not achieve exact quasi-symmetry, the plasma itself continually seeks lower energy states through helical 3D deformations, and reactors will likely have non-uniform distributions of ferritic steel near the plasma. Also, some level of designed-in 3D magnetic field structure is now anticipated for most concepts in order to lead to a stable, steady-state fusion reactor. Such planned 3D field structures can take many forms, ranging from tokamaks with weak 3D ELM-suppression fields to stellarators with more dominant 3D field structures. There is considerable interest in the development of unified physics models for the full range of 3D effects. Ultimately, the questions of how much symmetry breaking can be tolerated and how to optimize its design must be addressed for all fusion concepts. Fortunately, significant progress is underway in theory, computation and plasma diagnostics on many issues such as magnetic surface quality, plasma screening vs. amplification of 3D perturbations, 3D transport, influence on edge pedestal structures, MHD stability effects, modification of fast ion-driven instabilities, prediction of energetic particle heat loads on plasma-facing materials, effects of 3D fields on turbulence, and magnetic coil design. A closely coupled program of simulation, experimental validation, and design optimization is required to determine what forms and amplitudes of 3D shaping and symmetry breaking will be compatible with future fusion reactors. The development of models to address 3D physics and progress in these areas will be described. This work is supported both by the US Department of Energy under Contract DE

  9. Analysis of Performance of Selected AFC, ATF Fuels, and Lanthanide Transport

    Energy Technology Data Exchange (ETDEWEB)

    Unal, Cetin [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Galloway, Jack D. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2015-09-29

    We started to look at the performance of ATF concept in LWRs late in FY14 and finish our studies in FY15. The work has been presented in AFC review meetings, ICAPP and TOPFUEL conferences. The final version of the work is accepted for publication in Nuclear Engineering and Science Journal (NES). The copy of ICAPP and NES papers are attached separately to this document as our milestone deliverables. We made an important progress in the modeling of lanthanide transport in FY15. This work produced an ANS Winter Meeting paper and GLOBAL 2015 paper. GLOBAL 2015 paper is also attached as deliverable of FY15. The work on the lanthanide transport is preliminary. We are exploring other potential mechanisms, in addition to “liquid-like” diffusion mechanisms, proposed by Robert Mariani [1] before we analyze data that will be taken by Ohio State University. This year, we concentrate on developing diffusion kernels and principles of modeling. Next year, this work will continue and analyze the Ohio State data and develop approaches to solve multicomponent diffusion. In addition to three papers we attached to this report, we have done some research on coupling and the development of gas release model for metallic fuels in FY15. They are also preliminary in nature; therefore, we give the summary of what we found rather than an extended report that will be done in FY16.

  10. Viability of thin wall tube forming of ATF FeCrAl

    Energy Technology Data Exchange (ETDEWEB)

    Maloy, Stuart Andrew [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Aydogan, Eda [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Anderoglu, Osman [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Lavender, Curt [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Yamamoto, Yukinori [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2016-09-16

    Fabrication of thin walled tubing of FeCrAl alloys is critical to its success as a candidate enhanced accident tolerant fuel cladding material. Alloys that are being investigated are Generation I and Generation II FeCrAl alloys produced at ORNL and an ODS FeCrAl alloy, MA-956 produced by Special Metals. Gen I and Gen II FeCrAl alloys were provided by ORNL and MA-956 was provided by LANL (initially produced by Special Metals). Three tube development efforts were undertaken. ORNL led the FeCrAl Gen I and Gen II alloy development and tube processing studies through drawing tubes at Rhenium Corporation. LANL received alloys from ORNL and led tube processing studies through drawing tubes at Century Tubing. PNNL led the development of tube processing studies on MA-956 through pilger processing working with Sandvik Corporation. A summary of the recent progress on tube development is provided in the following report and a separate ORNL report: ORNL/TM-2015/478, “Development and Quality Assessments of Commercial Heat Production of ATF FeCrAl Tubes”.

  11. Viability of thin wall tube forming of ATF FeCrAl

    Energy Technology Data Exchange (ETDEWEB)

    Maloy, Stuart Andrew [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Aydogan, Eda [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Anderoglu, Osman [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Lavender, Curt [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Yamamoto, Yukinori [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2016-09-16

    Fabrication of thin walled tubing of FeCrAl alloys is critical to its success as a candidate enhanced accident-tolerant fuel cladding material. Alloys that are being investigated are Generation I and Generation II FeCrAl alloys produced at ORNL and an ODS FeCrAl alloy, MA-956 produced by Special Metals. Gen I and Gen II FeCrAl alloys were provided by ORNL and MA-956 was provided by LANL (initially produced by Special Metals). Three tube development efforts were undertaken. ORNL led the FeCrAl Gen I and Gen II alloy development and tube processing studies through drawing tubes at Rhenium Corporation. LANL received alloys from ORNL and led tube processing studies through drawing tubes at Century Tubing. PNNL led the development of tube processing studies on MA-956 through pilger processing working with Sandvik Corporation. A summary of the recent progress on tube development is provided in the following report and a separate ORNL report: ORNL/TM-2015/478, “Development and Quality Assessments of Commercial Heat Production of ATF FeCrAl Tubes”.

  12. Metformin-induced inhibition of the mitochondrial respiratory chain increases FGF21 expression via ATF4 activation

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Kook Hwan [Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon-dong Gangnam-gu, Seoul 135-710 (Korea, Republic of); Samsung Advanced Institute for Health Sciences and Technology, Sungkyunkwan University School of Medicine, 50 Irwon-dong Gangnam-gu, Seoul 135-710 (Korea, Republic of); Jeong, Yeon Taek [Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon-dong Gangnam-gu, Seoul 135-710 (Korea, Republic of); Kim, Seong Hun [Samsung Advanced Institute for Health Sciences and Technology, Sungkyunkwan University School of Medicine, 50 Irwon-dong Gangnam-gu, Seoul 135-710 (Korea, Republic of); Jung, Hye Seung; Park, Kyong Soo [Department of Internal Medicine, Seoul National University College of Medicine, 28 Yongon-dong Chongno-gu, Seoul 110-744 (Korea, Republic of); Lee, Hae-Youn [Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon-dong Gangnam-gu, Seoul 135-710 (Korea, Republic of); Lee, Myung-Shik, E-mail: mslee0923@skku.edu [Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon-dong Gangnam-gu, Seoul 135-710 (Korea, Republic of); Samsung Advanced Institute for Health Sciences and Technology, Sungkyunkwan University School of Medicine, 50 Irwon-dong Gangnam-gu, Seoul 135-710 (Korea, Republic of)

    2013-10-11

    Highlights: •Metformin induces FGF21 expression in an AMPK independent manner. •Metformin enhances FGF21 expression by inhibiting mitochondrial complex I activity. •The PERK-eIF2α-ATF4 axis is required for metformin-induced FGF21 expression. •Metformin activates the ATF4-FGF21 axis in the liver of mouse. •Metformin increases serum FGF21 level in diabetic human subjects. -- Abstract: Fibroblast growth factor 21 (FGF21) is an endocrine hormone that exhibits anti-obesity and anti-diabetes effects. Because metformin is widely used as a glucose-lowering agent in patients with type 2 diabetes (T2D), we investigated whether metformin modulates FGF21 expression in cell lines, and in mice or human subjects. We found that metformin increased the expression and release of FGF21 in a diverse set of cell types, including rat hepatoma FaO, primary mouse hepatocytes, and mouse embryonic fibroblasts (MEFs). Intriguingly, AMP-activated protein kinase (AMPK) was dispensable for the induction of FGF21 by metformin. Mammalian target of rapamycin complex 1 (mTORC1) and peroxisome proliferator-activated receptor α (PPARα), which are additional targets of metformin, were not involved in metformin-induced FGF21 expression. Importantly, inhibition of mitochondrial complex I activity by metformin resulted in FGF21 induction through PKR-like ER kinase (PERK)-eukaryotic translation factor 2α (eIF2α)-activating transcription factor 4 (ATF4). We showed that metformin activated ATF4 and increased FGF21 expression in the livers of mice, which led to increased serum levels of FGF21. We also found that serum FGF21 level was increased in human subjects with T2D after metformin therapy for 6 months. In conclusion, our results indicate that metformin induced expression of FGF21 through an ATF4-dependent mechanism by inhibiting mitochondrial respiration independently of AMPK. Therefore, FGF21 induction by metformin might explain a portion of the beneficial metabolic effects of metformin.

  13. Proceedings of the third symposium on the physics and technology of compact toroids in the magnetic fusion energy program

    Energy Technology Data Exchange (ETDEWEB)

    Siemon, R.E. (comp.)

    1981-03-01

    This document contains papers contributed by the participants of the Third Symposium on Physics and Technology of Compact Toroids in the Magnetic Fusion Energy Program. Subjects include reactor aspects of compact toroids, energetic particle rings, spheromak configurations (a mixture of toroidal and poloidal fields), and field-reversed configurations (FRC's that contain purely poloidal field).

  14. Toroidal bubbles with circulation in ideal hydrodynamics: A variational approach

    DEFF Research Database (Denmark)

    Ruban, V.P.; Juul Rasmussen, J.

    2003-01-01

    Incompressible, inviscid, irrotational, unsteady flows with circulation Gamma around a distorted toroidal bubble are considered. A general variational principle that determines the evolution of the bubble shape is formulated. For a two-dimensional (2D) cavity with a constant area A, exact...... pseudodifferential equations of motion are derived, based on variables that determine a conformal mapping of the unit circle exterior into the region occupied by the fluid. A closed expression for the Hamiltonian of the 2D system in terms of canonical variables is obtained. Stability of a stationary drifting 2D...... hollow vortex is demonstrated, when the gravity is small, gA(3/2)/Gamma(2)flows a simplified Lagrangian is suggested, inasmuch as the bubble shape is well described by the center line R(xi,t) and by an approximately circular cross section...

  15. Analysis of recurrent patterns in toroidal magnetic fields.

    Science.gov (United States)

    Sanderson, Allen R; Chen, Guoning; Tricoche, Xavier; Pugmire, David; Kruger, Scott; Breslau, Joshua

    2010-01-01

    In the development of magnetic confinement fusion which will potentially be a future source for low cost power, physicists must be able to analyze the magnetic field that confines the burning plasma. While the magnetic field can be described as a vector field, traditional techniques for analyzing the field's topology cannot be used because of its Hamiltonian nature. In this paper we describe a technique developed as a collaboration between physicists and computer scientists that determines the topology of a toroidal magnetic field using fieldlines with near minimal lengths. More specifically, we analyze the Poincaré map of the sampled fieldlines in a Poincaré section including identifying critical points and other topological features of interest to physicists. The technique has been deployed into an interactive parallel visualization tool which physicists are using to gain new insight into simulations of magnetically confined burning plasmas.

  16. On the interaction of turbulence and flows in toroidal plasmas

    Energy Technology Data Exchange (ETDEWEB)

    Stroth, U; Manz, P; Ramisch, M [Institut fuer Plasmaforschung, Universitaet Stuttgart, 70569 Stuttgart (Germany)

    2011-02-15

    In toroidally confined plasmas, background E x B flows, microturbulence and zonal flows constitute a tightly coupled dynamic system and the description of confinement transitions needs a self-consistent treatment of these players. The background radial electric field, linked to neoclassical ambipolar transport, has an impact on the interaction between zonal flows and turbulence by tilting and anisotropization of turbulent eddies. Zonal-flow drive is shown to be non-local in wavenumber space and is described as a straining-out process instead as a local inverse cascade. The straining-out process is also discussed as an option to explain turbulence suppression in sheared flows and could be the cause of predator-prey oscillations in the turbulence zonal-flow system.

  17. First assembly phase for the ATLAS toroid coils

    CERN Multimedia

    Maximilien Brice

    2003-01-01

    The ATLAS barrel toroid system consists of eight coils, each of axial length 25.3 m, assembled radially and symmetrically around the beam axis. The coils are of a flat racetrack type with two double-pancake windings made of 20.5 kA aluminium-stabilized niobium-titanium superconductor. In the first phase of assembly, the two 'pancakes' are packed into their vacuum vessel. This is done using bladders filled with resin and glass microbeads under pressure. The resin is heated and, once cooled, holds the pancakes in place. The operation has to be performed on both sides of the coil, which necessitated a special technique to turn the coils over and then transport them to the heating table. Photos 01, 02, 03: Transporting the coil to the heating table using a special lifting gantry manufactured at JINR-Dubna, Russia in preparation for the 'bladderisation' operation.

  18. Toroid Joining Gun. [thermoplastic welding system using induction heating

    Science.gov (United States)

    Buckley, J. D.; Fox, R. L.; Swaim, R J.

    1985-01-01

    The Toroid Joining Gun is a low cost, self-contained, portable low powered (100-400 watts) thermoplastic welding system developed at Langley Research Center for joining plastic and composite parts using an induction heating technique. The device developed for use in the fabrication of large space sructures (LSST Program) can be used in any atmosphere or in a vacuum. Components can be joined in situ, whether on earth or on a space platform. The expanded application of this welding gun is in the joining of thermoplastic composites, thermosetting composites, metals, and combinations of these materials. Its low-power requirements, light weight, rapid response, low cost, portability, and effective joining make it a candidate for solving many varied and unique bonding tasks.

  19. Gasdynamic characteristics of toroidal shock and detonation wave converging

    Institute of Scientific and Technical Information of China (English)

    TENG; Honghui; JIANG; Zonglin

    2005-01-01

    The modified CCW relation is applied to analyzing the shock, detonation wave converging and the role of chemical reactions in the process. Results indicate that the shock wave is strengthened faster than the detonation wave in the converging at the same initial Mach number. Euler equations implemented with a detailed chemical reaction model are solved to simulate toroidal shock and detonation wave converging. Gasdynamic characteristics of the converging are investigated, including wave interaction patterns, observable discrepancies and physical phenomena behind them. By comparing wave diffractions, converging processes and pressure evolutions in the focusing area, the different effects of chemical reactions on diffracting and converging processes are discussed and the analytic conclusion is demonstrated through the observation of numerical simulations.

  20. Differentially rotating magnetised neutron stars: production of toroidal magnetic fields

    CERN Document Server

    Thampan, A V

    2004-01-01

    We initiate numerical studies of differentially rotating magnetised (proto) neutron stars by studying - through construction from first principles - the coupling between an assumed differential rotation and an impressed magnetic field. For a perfect incompressible, homogeneous, non-dissipative fluid sphere immersed in an ambient plasma, we solve the (coupled) azimuthal components of the Navier-Stokes equation and the Maxwell induction equation. The assumed time--independent poloidal field lines get dragged by the rotating fluid and produce toroidal magnetic fields. Surface magnetic fields take away energy redistributing the angular momentum to produce rigid rotation along poloidal field lines. Due to absence of viscous dissipation, sustained torsional oscillations are set up within the star. However, the perpetual oscillations of neighbouring `closed' field lines get increasingly out of phase with time, leading to structure build up as in Liu & Shapiro (2004) implying the importance of taking into account...

  1. Stability of the toroidal magnetic field in stellar radiation zones

    CERN Document Server

    Bonanno, Alfio

    2011-01-01

    Understanding the stability of the magnetic field in radiation zones is of crucial importance for various processes in stellar interior like mixing, circulation and angular momentum transport. The stability properties of a star containing a prominent toroidal field in a radiation zone is investigated by means of a linear stability analysis in the Boussinesq approximation taking into account the effect of thermal conductivity. The growth rate of the instability is explicitly calculated and the effects of stable stratification and heat transport are discussed in detail. It is argued that the stabilizing influence of gravity can never entirely suppress the instability caused by electric currents in radiation zones although the stable stratification can significantly decrease the growth rate of instability

  2. Transport Bifurcation Induced by Sheared Toroidal Flow in Tokamak Plasmas

    CERN Document Server

    Highcock, E G; Parra, F I; Schekochihin, A A; Roach, C M; Cowley, S C

    2011-01-01

    First-principles numerical simulations are used to describe a transport bifurcation in a differentially rotating tokamak plasma. Such a bifurcation is more probable in a region of zero magnetic shear, where the component of the sheared toroidal flow that is perpendicular to the magnetic field has the strongest suppressing effect on the turbulence, than one of finite magnetic shear. Where the magnetic shear is zero, there are no growing linear eigenmodes at any finite value of flow shear. However, subcritical turbulence can be sustained, owing to the transient growth of modes driven by the ion temperature gradient (ITG) and the parallel velocity gradient (PVG). Nonetheless, in a parameter space containing a wide range of temperature gradients and velocity shears, there is a sizeable window where all turbulence is suppressed. Combined with the relatively low transport of momentum by collisional (neoclassical) mechanisms, this produces the conditions for a bifurcation from low to high temperature and velocity gr...

  3. Density Measurement of Compact Toroid with Mach-Zehnder Interferometer

    Science.gov (United States)

    Laufman-Wollitzer, Lauren; Endrizzi, Doug; Brookhart, Matt; Flanagan, Ken; Forest, Cary

    2016-10-01

    Utilizing a magnetized coaxial plasma gun (MCPG) built by Tri Alpha Energy, a dense compact toroid (CT) is created and injected at high speed into the Wisconsin Plasma Astrophysics Laboratory (WiPAL) vessel. A modified Mach-Zehnder interferometer from the Line-Tied Reconnection Experiment (LTRX) provides an absolute measurement of electron density. The interferometer is located such that the beam intersects the plasma across the diameter of the MCPG drift region before the CT enters the vessel. This placement ensures that the measurement is taken before the CT expand. Results presented will be used to further analyze characteristics of the CT. Funding provided by DoE, NSF, and WISE Summer Research.

  4. Global Theory to Understand Toroidal Drift Waves in Steep Gradient

    CERN Document Server

    Xie, Hua-Sheng

    2016-01-01

    Toroidal drift waves with unconventional mode structures and non-ground eigenstates, which differ from typical ballooning structure mode, are found to be important recently by large scale global gyrokinetic simulations and especially become dominant at strong gradient edge plasmas [cf., Xie and Xiao, Phys. Plasmas, 22, 090703 (2015)]. The global stability and mode structures of drift wave in this steep edge density and temperature gradients are examined by both direct numerical solutions of a model two-dimensional eigen equation and analytical theory employing WKB-ballooning approach. Theory agrees with numerical solutions quite well. Our results indicate that (i) non-ground eigenstates and unconventional mode structures generally exist and can be roughly described by two parameters `quantum number' $l$ and ballooning angle $\\vartheta_k$, (ii) local model can overestimate the growth rate largely, say, $>50\\%$, and (iii) the narrow steep equilibrium profile leads to twisting (triangle-like) radial mode structu...

  5. Heterotic free fermionic and symmetric toroidal orbifold models

    CERN Document Server

    Athanasopoulos, P; Nibbelink, S Groot; Mehta, V M

    2016-01-01

    Free fermionic models and symmetric heterotic toroidal orbifolds both constitute exact backgrounds that can be used effectively for phenomenological explorations within string theory. Even though it is widely believed that for Z2xZ2 orbifolds the two descriptions should be equivalent, a detailed dictionary between both formulations is still lacking. This paper aims to fill this gap: We give a detailed account of how the input data of both descriptions can be related to each other. In particular, we show that the generalized GSO phases of the free fermionic model correspond to generalized torsion phases used in orbifold model building. We illustrate our translation methods by providing free fermionic realizations for all Z2xZ2 orbifold geometries in six dimensions.

  6. Manufacturing aspects of the ATLAS barrel toroid double pancakes

    CERN Document Server

    Drago, G; Gagliardi, P; Laurenti, A; Marabotto, R; Penco, R

    2002-01-01

    In 1999 INFN (Istituto Nazionale di Fisica Nucleare) ordered to ANSALDO the manufacturing of 16 double pancakes for the ATLAS BARREL TOROID. In July 2001 four Double Pancakes have already been completed and shipped to the integration site. In this paper the main aspects of the manufacturing of the largest superconducting coils ever built (5*25 m) are described. The main phases of the manufacturing procedure are reviewed starting from the conductor preparation to the VPI impregnation, including references to the materials used as well as to the relevant customer's requirements. In particular the special winding form and the winding technique are treated. For each phase the most critical aspects and the relevant solutions are pointed out. Particular details about the technical solutions adopted for the impregnation and curing of the Double Pancake, which could not be performed inside an autoclave due to the huge dimension of the coil itself, are reported. Finally the methods used for the dimensional and electri...

  7. Cleaning procedure for improved photothermal background of toroidal optical microresonators

    Science.gov (United States)

    Horak, Erik H.; Knapper, Kassandra A.; Heylman, Kevin D.; Goldsmith, Randall H.

    2016-09-01

    High Q-factors and small mode volumes have made toroidal optical microresonators exquisite sensors to small shifts in the effective refractive index of the WGM modes. Eliminating contaminants and improving quality factors is key for many different sensing techniques, and is particularly important for photothermal imaging as contaminants add photothermal background obscuring objects of interest. Several different cleaning procedures including wet- and dry-chemical procedures are tested for their effect on Q-factors and photothermal background. RCA cleaning was shown to be successful in contrast to previously described acid cleaning procedures, most likely due to the different surface reactivity of the acid reagents used. UV-ozone cleaning was shown to be vastly superior to O2 plasma cleaning procedures, significantly reducing the photothermal background of the resonator.

  8. The Kirchhoff Index of Toroidal Meshes and Variant Networks

    Directory of Open Access Journals (Sweden)

    Jia-Bao Liu

    2014-01-01

    Full Text Available The resistance distance is a novel distance function on electrical network theory proposed by Klein and Randić. The Kirchhoff index Kf(G is the sum of resistance distances between all pairs of vertices in G. In this paper, we established the relationships between the toroidal meshes network Tm×n and its variant networks in terms of the Kirchhoff index via spectral graph theory. Moreover, the explicit formulae for the Kirchhoff indexes of L(Tm×n, S(Tm×n, T(Tm×n, and C(Tm×n were proposed, respectively. Finally, the asymptotic behavior of Kirchhoff indexes in those networks is obtained by utilizing the applications of analysis approach.

  9. Ion temperature and toroidal rotation in JET's low torque plasmas

    Science.gov (United States)

    Bernardo, J.; Nave, M. F. F.; Giroud, C.; Reyes Cortes, S.; Bizarro, João P. S.

    2016-11-01

    This paper reports on the procedure developed as the best method to provide an accurate and reliable estimation of the ion temperature Ti and the toroidal velocity vϕ from Charge-eXchange Recombination Spectroscopy (CXRS) data from intrinsic rotation experiments at the Joint European Torus with the carbon wall. The low impurity content observed in such plasmas, resulting in low active CXRS signal, alongside low Doppler shifts makes the determination of Ti and vϕ particularly difficult. The beam modulation method will be discussed along with the measures taken to increase photon statistics and minimise errors from the absolute calibration and magneto-hydro-dynamics effects that may impact the CXRS passive emission.

  10. Effects of magnetic islands on bootstrap current in toroidal plasmas

    Science.gov (United States)

    Dong, G.; Lin, Z.

    2017-03-01

    The effects of magnetic islands on electron bootstrap current in toroidal plasmas are studied using gyrokinetic simulations. The magnetic islands cause little changes of the bootstrap current level in the banana regime because of trapped electron effects. In the plateau regime, the bootstrap current is completely suppressed at the island centers due to the destruction of trapped electron orbits by collisions and the flattening of pressure profiles by the islands. In the collisional regime, small but finite bootstrap current can exist inside the islands because of the pressure gradients created by large collisional transport across the islands. Finally, simulation results show that the bootstrap current level increases near the island separatrix due to steeper local density gradients.

  11. The angular momentum transport by unstable toroidal magnetic fields

    CERN Document Server

    Ruediger, G; Spada, F; Tereshin, I

    2014-01-01

    We demonstrate with a nonlinear MHD code that angular momentum can be transported due to the magnetic instability of toroidal fields under the influence of differential rotation, and that the resulting effective viscosity may be high enough to explain the almost rigid-body rotation observed in radiative stellar cores. The fields are assumed strong enough and the density stratification weak enough that the influence of the 'negative' buoyancy in the radiative zones can be neglected. Only permanent current-free fields and only those combinations of rotation rates and magnetic field amplitudes which provide maximal numerical values of the viscosity are considered. We find that the dimensionless ratio of the turbulent over molecular viscosity, \

  12. Parametric design studies of toroidal magnetic energy storage units

    Science.gov (United States)

    Herring, J. Stephen

    Superconducting magnetic energy storage (SMES) units have a number of advantages as storage devices. Electrical current is the input, output and stored medium, allowing for completely solid-state energy conversion. The magnets themselves have no moving parts. The round trip efficiency is higher than those for batteries, compressed air or pumped hydro. Output power can be very high, allowing complete discharge of the unit within a few seconds. Finally, the unit can be designed for a very large number of cycles, limited basically by fatigue in the structural components. A small systems code was written to produce and evaluate self-consistent designs for toroidal superconducting energy storage units. The units can use either low temperature or high temperature superconductors. The coils have D shape where the conductor and its stabilizer/structure is loaded only in tension and the centering forces are borne by a bucking cylinder. The coils are convectively cooled from a cryogenic reservoir in the bore of the coils. The coils are suspended in a cylindrical metal shell which protects the magnet during rail, automotive or shipboard use. It is important to note that the storage unit does not rely on its surroundings for structural support, other than normal gravity and inertial loads. Designs are presented for toroidal energy storage units produced by the systems code. A wide range of several parameters have been considered, resulting in units storing from 1 MJ to 72 GJ. Maximum fields range from 5 T to 20 T. The masses and volumes of the coils, bucking cylinder, coolant, insulation and outer shell are calculated. For unattended use, the allowable operating time using only the boiloff of the cryogenic fluid for refrigeration is calculated. For larger units, the coils were divided into modules suitable for normal truck or rail transport.

  13. Steady state toroidal magnetic field at earth's core-mantle boundary

    Science.gov (United States)

    Levy, Eugene H.; Pearce, Steven J.

    1991-01-01

    Measurements of the dc electrical potential near the top of earth's mantle have been extrapolated into the deep mantle in order to estimate the strength of the toroidal magnetic field component at the core-mantle interface. Recent measurements have been interpreted as indicating that at the core-mantle interface, the magnetic toroidal and poloidal field components are approximately equal in magnitude. A motivation for such measurements is to obtain an estimate of the strength of the toroidal magnetic field in the core, a quantity important to our understanding of the geomagnetic field's dynamo generation. Through the use of several simple and idealized calculation, this paper discusses the theoretical relationship between the amplitude of the toroidal magnetic field at the core-mantle boundary and the actual amplitude within the core. Even with a very low inferred value of the toroidal field amplitude at the core-mantle boundary, (a few gauss), the toroidal field amplitude within the core could be consistent with a magnetohydrodynamic dynamo dominated by nonuniform rotation and having a strong toroidal magnetic field.

  14. A Pre-ionization System to Limit Neutral Gas in a Compact Toroid Injector

    Science.gov (United States)

    Allfrey, Ian; Roche, Thomas; Matsumoto, Tadafumi; Garate, Eusebio; Gota, Hiroshi; Asai, Tomohiko; the TAE Team

    2016-10-01

    Fusion plasmas require long lifetimes and high temperatures, both of which are limited by particle loss, among other factors. Therefore, refueling a long-lived advanced beam-driven field-reversed configuration (FRC) plasma in C-2U is necessary, and injecting a supersonic compact toroid (CT) is an effective means of introducing particles into the FRC core. However, neutral gas that trails the CT into the target chamber cools the FRC. Pre-ionization (PI) system assists the break down between electrodes of the CT injector (CTI), so the amount of introduced gas can be lowered by up to a factor of two, effectively increasing the ionization fraction; thus, reducing the amount of neutral gas in the system. Additionally, the PI decreases the delay in CTI breakdown so a highly reproducible operation is achievable. The PI system consists of a fast, high voltage, pulse discharge circuit coupled to a Teflon insulated semi-rigid coaxial cable inserted into the CTI. System details and experimental data will be presented, in addition to issues such as the introduction of impurities and pre-ionizer lifetime.

  15. Conservation laws for collisional and turbulent transport processes in toroidal plasmas with large mean flows

    Science.gov (United States)

    Sugama, H.; Nunami, M.; Nakata, M.; Watanabe, T.-H.

    2017-02-01

    A novel gyrokinetic formulation is presented by including collisional effects into the Lagrangian variational principle to yield the governing equations for background and turbulent electromagnetic fields and gyrocenter distribution functions, which can simultaneously describe classical, neoclassical, and turbulent transport processes in toroidal plasmas with large toroidal flows on the order of the ion thermal velocity. Noether's theorem modified for collisional systems and the collision operator given in terms of Poisson brackets are applied to derivation of the particle, energy, and toroidal momentum balance equations in the conservative forms, which are desirable properties for long-time global transport simulation.

  16. Low Collisionality Neoclassical Toroidal Viscosity in Tokamaks and Quasi-symmetric Stellarators

    Science.gov (United States)

    Cole, A. J.; Hegna, C. C.; Callen, J. D.

    2008-11-01

    Non-resonant magnetic perturbations can affect plasma rotation in toroidally confined plasmas through their modification to |B|. Variations along a field line induce nonambipolar radial transport and produce a global neoclassical toroidal viscous force [NTV]. In this work, previously calculated radial particle fluxes for the low-collisionality ``ν'' and ``1/ν'' regimes [1] are unified into a single particle flux (or toroidal viscous force). Provided pitch-angle scattering dominates over collisional energy exchange, the energy component of phase space can be decoupled into independent regions (E >Ec. for ν regime, E Callen, Phys. Fluids 19, 667 (1976).

  17. Theoretical studies of possible toroidal high-spin isomers in the light-mass region

    CERN Document Server

    Staszczak, Andrzej

    2015-01-01

    We review our theoretical knowledge of possible toroidal high-spin isomers in the light mass region in 28$\\le$$A$$\\le$52 obtained previously in cranked Skyrme-Hartree-Fock calculations. We report additional toroidal high-spin isomers in $^{56}$Ni with $I$=114$\\hbar$ and 140$\\hbar$, which follow the same (multi-particle)--(multi-hole) systematics as other toroidal high-spin isomers. We examine the production of these exotic nuclei by fusion of various projectiles on $^{20}$Ne or $^{28}$Si as an active target in time-projection-chamber (TCP) experiments.

  18. EMC3-EIRENE modeling of toroidally-localized divertor gas injection experiments on Alcator C-Mod

    Energy Technology Data Exchange (ETDEWEB)

    Lore, J.D., E-mail: lorejd@ornl.gov [Oak Ridge National Laboratory, Oak Ridge, TN 37831 (United States); Reinke, M.L. [York Plasma Institute, Department of Physics, University of York, Heslington, York YO10 5DD (United Kingdom); LaBombard, B. [Plasma Science and Fusion Center, MIT, Cambridge, MA 02139 (United States); Lipschultz, B. [York Plasma Institute, Department of Physics, University of York, Heslington, York YO10 5DD (United Kingdom); Churchill, R.M. [Plasma Science and Fusion Center, MIT, Cambridge, MA 02139 (United States); Pitts, R.A. [ITER Organization, Route de Vinon sur Verdon, 13115 Saint Paul Lez Durance (France); Feng, Y. [Max Planck Institute for Plasma Physics, Greifswald (Germany)

    2015-08-15

    Experiments on Alcator C-Mod with toroidally and poloidally localized divertor nitrogen injection have been modeled using the three-dimensional edge transport code EMC3-EIRENE to elucidate the mechanisms driving measured toroidal asymmetries. In these experiments five toroidally distributed gas injectors in the private flux region were sequentially activated in separate discharges resulting in clear evidence of toroidal asymmetries in radiated power and nitrogen line emission as well as a ∼50% toroidal modulation in electron pressure at the divertor target. The pressure modulation is qualitatively reproduced by the modeling, with the simulation yielding a toroidal asymmetry in the heat flow to the outer strike point. Toroidal variation in impurity line emission is qualitatively matched in the scrape-off layer above the strike point, however kinetic corrections and cross-field drifts are likely required to quantitatively reproduce impurity behavior in the private flux region and electron temperatures and densities directly in front of the target.

  19. Recent JET experiments on Alfven eigenmodes with intermediate toroidal mode numbers: measurements and modelling of n=3 toroidal Alfven eigenmodes with the TAEFL code

    Energy Technology Data Exchange (ETDEWEB)

    Testa, D. [CRPP, Switzerland; Spong, Donald A [ORNL; Panis, T. [CRPP, Switzerland; Blanchard, P. [CRPP, Switzerland; Fasoli, A. [CRPP, Switzerland

    2011-01-01

    This paper reports the results of recent experiments performed on the JET tokamak on Alfven eigenmodes (AEs) with toroidal mode number (n) in the range n = 3-15. The stability properties of these medium-n AEs are investigated experimentally using a new set of compact in-vessel antennas, providing a direct and real-time measurement of the frequency, damping rate and amplitude for each individual toroidal mode number. We report here the quantitative analysis of the measurements of the damping rate for stable n = 3 toroidal AEs as a function of the edge plasma elongation, and the theoretical analysis of these data with the TAEFL code. The TAEFL results are in excellent qualitative agreement with the measurements, reproducing well the experimental scaling of increasing damping rate versus increasing edge elongation, and in many cases are also quantitatively correct, with a difference with respect to the measurements below 30%, particularly for magnetic configurations that have a larger edge magnetic shear.

  20. Quench Induced Pressure Rise in the Cooling Pipes of the Atlas Barrel Toroid Model

    CERN Document Server

    Haug, F; Broggi, F; Junker, S

    2004-01-01

    The ATLAS superconducting magnet system consists of a Barrel Toroid, two End-Cap Toroids and a Solenoid. Eight individual racetrack coils will be assembled to form the Barrel Toroid with overall dimensions of 26 m length and 20 m diameter. In order to verify the design concept a 9 m long short version of a single Barrel Toroid coil was built. A test program was conducted at the CERN cryogenic test facility which included the evaluation of the pressure rise in the helium cooling channels during quenches of the coil. A specific experimental set-up with cold pressure transducers and capillaries was installed for online measurement of the pressure signals. In addition a computer model was used to simulate these events. The data obtained are presented.

  1. Hall Equilibria: Solutions with toroidal and poloidal magnetic fields in Neutron Star Crusts

    CERN Document Server

    Gourgouliatos, K N; Lyutikov, M; Reisenegger, A

    2013-01-01

    We present Hall equilibrium solutions for neutron stars crusts containing toroidal and poloidal magnetic field. Some simple cases are solved analytically while more complicated configurations are found numerically through a Gauss-Seidel elliptic partial differential equation solver.

  2. Three Cycles of the Solar Toroidal Magnetic Field and This Peculiar Minimum

    CERN Document Server

    Lo, Leyan; Scherrer, Phil

    2010-01-01

    Thirty-four years of WSO (Wilcox Solar Observatory) and thirteen years of SOHO/MDI (Michelson Doppler Imager on the Solar and Heliospheric Observatory) magnetograms have been studied to measure the east-west inclination angle, indicating the toroidal component of the photospheric magnetic field. This analysis reveals that the large-scale toroidal component of the global magnetic field is antisymmetric around the equator and reverses direction in regions associated with flux from one solar cycle compared to the next. The toroidal field revealed the first early signs of cycle 24 at high latitudes, especially in the northern hemisphere, appearing as far back as 2003 in the WSO data and 2004 in MDI. As in previous cycles, the feature moves gradually equatorward. Cycles overlap and the pattern associated with each cycle lasts about 17 years. Even though the polar field at the current solar minimum is significantly lower than the three previous minima, the toroidal field pattern is similar.

  3. Evolution of views on the structure of the ambipolar electric field in toroidal magnetic confinement systems

    Energy Technology Data Exchange (ETDEWEB)

    Kovrizhnykh, L. M., E-mail: lmkov@fpl.gpi.ru [Russian Academy of Sciences, Prokhorov General Physics Institute (Russian Federation)

    2015-12-15

    Various methods of determining the ambipolar electric field in toroidal magnetic systems (predominantly, in stellarators) and the evolution of views on this problem are discussed. Paradoxes encountered in solving this problem are analyzed, and ways of resolving them are proposed.

  4. TORQUE CAPACITY AND CONTACT EFFICIENCY OF A HALF TOROIDAL CONTINUOUSLY VARLABLE TRANSMISSIONS

    Institute of Scientific and Technical Information of China (English)

    Nabil Abdulla Attia; Qin Datong; Shi Wankai; Amir Ibrahim Ali

    2004-01-01

    The automotive industry is seeking new concepts for a continuously variable transmission (CVT) in the driveline. One possible solution for a CVT design is half toroidal traction drive, providing a high torque capacity with quick ratio change. An analytical study on the contact points of the half toroidal CVT has been detailed. The shapes of the contact areas among the input disk, power roller and output disk are considered ellipses. Mathematical equations for estimating the torque capacity, power loss due to spin action, and contact efficiency of the elliptical contacts of the half toroidal CVT are formulated and expressed in the form of integrals which can be readily evaluated by numerical scheme. The contact efficiency calculations of the half toroidal CVT have been developed for the proper spin point locations under the effect of system parameters. Numerical results are presented in graphical forms for considered parameters, which can help the designer to select the proper system parameters to minimize the undesirable spin effects.

  5. Calculation about a modification to the toroidal magnetic field of the Tokamak Novillo. Part I; Calculo sobre una modificacion al campo magnetico toroidal del Tokamak Novillo. Parte I

    Energy Technology Data Exchange (ETDEWEB)

    Chavez A, E.; Melendez L, L.; Colunga S, S.; Valencia A, R.; Lopez C, R.; Gaytan G, E

    1991-07-15

    The charged particles that constitute the plasma in the tokamaks are located in magnetic fields that determine its behavior. The poloidal magnetic field of the plasma current and the toroidal magnetic field of the tokamak possess relatively big gradients, which produce drifts on these particles. These drifts are largely the cause of the continuous lost of particles and of energy of the confinement region. In this work the results of numerical calculations of a modification to the 'traditional' toroidal magnetic field that one waits it diminishes the drifts by gradient and improve the confinement properties of the tokamaks. (Author)

  6. Injection of electron beam into a toroidal trap using chaotic orbits near magnetic null.

    Science.gov (United States)

    Nakashima, C; Yoshida, Z; Himura, H; Fukao, M; Morikawa, J; Saitoh, H

    2002-03-01

    Injection of charged particle beam into a toroidal magnetic trap enables a variety of interesting experiments on non-neutral plasmas. Stationary radial electric field has been produced in a toroidal geometry by injecting electrons continuously. When an electron gun is placed near an X point of magnetic separatrix, the electron beam spreads efficiently through chaotic orbits, and electrons distribute densely in the torus. The current returning back to the gun can be minimized less than 1% of the total emission.

  7. The turbulent diffusion of toroidal magnetic flux as inferred from properties of the sunspot butterfly diagram

    Science.gov (United States)

    Cameron, R. H.; Schüssler, M.

    2016-06-01

    Context. In order to match observed properties of the solar cycle, flux-transport dynamo models require the toroidal magnetic flux to be stored in a region of low magnetic diffusivity, typically located at or below the bottom of the convection zone. Aims: We infer the turbulent magnetic diffusivity affecting the toroidal field on the basis of empirical data. Methods: We considered the time evolution of mean latitude and width of the activity belts of solar cycles 12-23 and their dependence on cycle strength. We interpreted the decline phase of the cycles as a diffusion process. Results: The activity level of a given cycle begins to decline when the centers of its equatorward propagating activity belts come within their (full) width (at half maximum) from the equator. This happens earlier for stronger cycles because their activity belts are wider. From that moment on, the activity and the belt width decrease in the same manner for all cycles, independent of their maximum activity level. In terms of diffusive cancellation of opposite-polarity toroidal flux across the equator, we infer the turbulent diffusivity experienced by the toroidal field, wherever it is located, to be in the range 150-450 km2 s-1. Strong diffusive latitudinal spreading of the toroidal flux underneath the activity belts can be inhibited by an inflow toward the toroidal field bands in the convection zone with a magnitude of several meters per second. Conclusions: The inferred value of the turbulent magnetic diffusivity affecting the toroidal field agrees, to order of magnitude, with estimates based on mixing-length models for the solar convection zone. This is at variance with the requirement of flux-transport dynamo models. The inflows required to keep the toroidal field bands together before they approach the equator are similar to the inflows toward the activity belts observed with local helioseismology.

  8. Influence of toroidal effects on the stability of the internal kink mode

    Energy Technology Data Exchange (ETDEWEB)

    Galvao, R.M.O.; Sakanaka, P.H.; Shigueoka, H.

    1978-09-25

    Using the sigma-stability technique, we study the stability of the internal kink mode in toroidal geometry. We show that there are two unstable regions separated by a stable on in a ..beta..-q/sub c/ stability diagram. In one of these regions toroidal effects are stabilizing and in the other they are destabilizing. Discrepant results of previous analytical theories and experimental results are explained.

  9. Tokamak equilibria with strong toroidal current density reversal

    Science.gov (United States)

    Ludwig, G. O.; Rodrigues, Paulo; Bizarro, João P. S.

    2013-05-01

    The equilibrium of large magnetic islands in the core of a tokamak under conditions of strong toroidal current density reversal is investigated by a new method. The method uses distinct spectral representations to describe each simply connected region as well as the containing shell geometry. This ideal conducting shell may substitute for the plasma edge region or take a virtual character representing the external equilibrium field effect. The internal equilibrium of the islands is solved within the framework of the variational moment method. Equivalent surface current densities are defined on the boundaries of the islands and on the thin containing shell, giving a straightforward formulation to the interaction between regions. The equilibrium of the island-shell system is determined by matching moments of the Dirichlet boundary conditions. Finally, the macroscopic stability against a class of tilting displacements is examined by means of an energy principle. It is found out that the up-down symmetric islands are stable to this particular perturbation and geometry but the asymmetric system presents a bifurcation in the equilibrium.

  10. Thomson scattering diagnostic on the Compact Toroidal Hybrid Experiment

    Science.gov (United States)

    Traverso, Peter; Maurer, D. A.; Ennis, D. A.; Hartwell, G. J.

    2016-10-01

    A Thomson scattering system is being commissioned for the non-axisymmetric plasmas of the Compact Toroidal Hybrid (CTH), a five-field period current-carrying torsatron. The system takes a single point measurement at the magnetic axis to both calibrate the two- color soft x-ray Te system and serve as an additional diagnostic for the V3FIT 3D equilibrium reconstruction code. A single point measurement will reduce the uncertainty in the reconstructed peak pressure by an order of magnitude for both current-carrying plasmas and future gyrotron-heated stellarator plasmas. The beam, generated by a frequency doubled Continuum 2 J, Nd:YaG laser, is passed vertically through an entrance Brewster window and a two-aperture optical baffle system to minimize stray light. The beam line propagates 8 m to the CTH device mid-plane with the beam diameter < 3 mm inside the plasma volume. Thomson scattered light is collected by two adjacent f/2 plano-convex condenser lenses and focused onto a custom fiber bundle. The fiber is then re-bundled and routed to a Holospec f/1.8 spectrograph to collect the red-shifted scattered light from 535-565 nm. The system has been designed to measure plasmas with core Te of 100 to 200 eV and densities of 5 ×1018 to 5 ×1019 m-3. Work supported by USDOE Grant DE-FG02-00ER54610.

  11. LQR Controller for Toroidal Continuously Variable Transmission in Reverse Motion

    Science.gov (United States)

    Mensler, Michel; Kawabe, Taketoshi; Joe, Shinichiro

    The system considered in this paper is a Toroidal Continuously Variable Transmission (TCVT) system for cars. This system is unstable in reverse motion as some mechanical parts have been removed from the original one for cost reduction, and the gear ratio has to be regulated around its nominal value for car reverse motion. The control theory used here is the Linear Quadratic Regulator (LQR) associated to a gain-scheduling technique, as the TCVT system is nonlinear according to the car speed. Moreover, as the LQR method requires the entire TCVT state vector and as the only available signal is the gear ratio, a full-order observer is designed. In order to take the other nonlinearities of the system into account, the observer is nonlinear: a diffeomorphism is then used for converting the variables provided by the nonlinear observer into the needed variables. In order to verify the effectiveness and the robustness of the controller against the car speed and the torque shift disturbance phenomenon, several experiments with a test-bed and with an actual vehicle have been performed and showed the efficiency of the proposed controller.

  12. Development of Compact Toroid Injector for C-2 FRCs

    Science.gov (United States)

    Matsumoto, Tadafumi; Sekiguchi, Junichi; Asai, Tomohiko; Gota, Hiroshi; Garate, Eusebio; Allfrey, Ian; Valentine, Travis; Smith, Brett; Morehouse, Mark; TAE Team

    2014-10-01

    Collaborative research project with Tri Alpha Energy has been started and we have developed a new compact toroid (CT) injector for the C-2 device, mainly for fueling field-reversed configurations (FRCs). The CT is formed by a magnetized coaxial plasma-gun (MCPG), which consists of coaxial cylinder electrodes; a spheromak-like plasma is generated by discharge and pushed out from the gun by Lorentz force. The inner diameter of outer electrode is 83.1 mm and the outer diameter of inner electrode is 54.0 mm. The surface of the inner electrode is coated with tungsten in order to reduce impurities coming out from the electrode. The bias coil is mounted inside of the inner electrode. We have recently conducted test experiments and achieved a supersonic CT translation speed of up to ~100 km/s. Other typical plasma parameters are as follows: electron density ~ 5 × 1021 m-3, electron temperature ~ 40 eV, and the number of particles ~0.5-1.0 × 1019. The CT injector is now planned to be installed on C-2 and the first CT injection experiment will be conducted in the near future. The detailed MCPG design as well as the test experimental results will be presented.

  13. Control of Compact-Toroid Characteristics by External Copper Shell

    Science.gov (United States)

    Matsumoto, T.; Sekiguchi, J.; Asai, T.; Gota, H.; Roche, T.; Allfrey, I.; Cordero, M.; Garate, E.; Kinley, J.; Valentine, T.; Waggoner, W.; the TAE Team

    2015-11-01

    A collaborative research project by Tri Alpha Energy and Nihon University has been conducted for several years, which led to the development of a new compact toroid (CT) injector for efficient FRC particle refueling in the C-2U experiment. The CT is formed by a magnetized coaxial plasma gun (MCPG), consisting of coaxial cylindrical electrodes. In CT formation via MCPG, the magnetic helicity content of the generated CT is one of the critical parameters. A bias coil is inserted into the inner electrode to generate a poloidal flux. The resultant bias magnetic field is spread out of MCPG with time due to its low-frequency bias current. To obtain a more effectively distributed bias magnetic field as well as to improve the voltage breakdown between electrodes, the MCPG incorporates a novel ~ 1 mm thick copper shell mounted outside of the outer electrode. This allows for reliable and controlled operation and more robust CT generation. A detailed discussion of the copper shell and experimental test results will be presented.

  14. Validation of Helium Inlet Design for ITER Toroidal Field Coil

    CERN Document Server

    Boyer, C; Hamada, K; Foussat, A; Le Rest, M; Mitchell, N; Decool, P; Savary, F; Sgobba, S; Weiss, K-P

    2014-01-01

    The ITER organization has performed design and its validation tests on a helium inlet structure for the ITER Toroidal Field (TF) coil under collaboration with CERN, KIT, and CEA-Cadarache. Detailed structural analysis was performed in order to optimize the weld shape. A fatigue resistant design on the fillet weld between the shell covers and the jacket is an important point on the helium inlet structure. A weld filler material was selected based on tensile test at liquid helium temperature after Nb3Sn reaction heat treatment. To validate the design of the weld joint, fatigue tests at 7 K were performed using heat-treated butt weld samples. A pressure drop measurement of a helium inlet mock-up was performed by using nitrogen gas at room temperature in order to confirm uniform flow distribution and pressure drop characteristic. These tests have validated the helium inlet design. Based on the validation, Japanese and European Union domestic agencies, which have responsibilities of the TF coil procurement, are pr...

  15. Global theory to understand toroidal drift waves in steep gradient

    Science.gov (United States)

    Xie, Hua-sheng; Li, Bo

    2016-08-01

    Toroidal drift waves with unconventional mode structures and non-ground eigenstates, which differ from a typical ballooning structure mode, are found to be important recently by large scale global gyrokinetic simulations and especially become dominant at strong gradient edge plasmas [cf. H. S. Xie and Y. Xiao, Phys. Plasmas 22, 090703 (2015)]. The global stability and mode structures of drift wave in this steep edge density and temperature gradients are examined by both direct numerical solutions of a model two-dimensional eigen equation and analytical theory employing WKB-ballooning approach. Theory agrees with numerical solutions quite well. Our results indicate that (i) non-ground eigenstates and unconventional mode structures generally exist and can be roughly described by two parameters "quantum number" l and ballooning angle ϑk , (ii) local model can overestimate the growth rate largely, say, >50 % , and (iii) the narrow steep equilibrium profile leads to twisting (triangle-like) radial mode structures. With velocity space integral, semi-local theory predicts that the critical jump gradient of the most unstable ion temperature gradient mode from ground state l = 0 to non-ground state l = 1 is LT-1R ˜50 . These features can have important consequences to turbulent transport.

  16. First assembly phase for the ATLAS toroid coils

    CERN Multimedia

    Patrice Loïez

    2003-01-01

    The ATLAS barrel toroid system consists of eight coils, each of axial length 25.3 m, assembled radially and symmetrically around the beam axis. The coils are of a flat racetrack type with two double-pancake windings made of 20.5 kA aluminium-stabilized niobium-titanium superconductor. In the first phase of assembly, the two 'pancakes' are packed into their vacuum vessel. This is done using bladders filled with resin and glass microbeads under pressure. The resin is heated and, once cooled, holds the pancakes in place. The operation has to be performed on both sides of the coil, which necessitated a special technique to turn the coils over and then transport them to the heating table. Photos 01, 02, 03: Use of the overhead travelling crane to hoist the coil up and then tilt it over, the coil frame's metal feet being used as rotational pivots, supporting half the coil's weight. Once it has been turned over, the coil, now with only half the frame, is transported to the heating table using a special lifting gant...

  17. Toroidal and poloidal magnetic fields at Venus. Venus Express observations

    Science.gov (United States)

    Dubinin, E.; Fraenz, M.; Woch, J.; Zhang, T. L.; Wei, Y.; Fedorov, A.; Barabash, S.; Lundin, R.

    2013-10-01

    Magnetic field and plasma measurements carried out onboard Venus Express during solar minimum conditions suggest the existence of two kinds of magnetic field configuration in the Venusian ionosphere. We interpret these as the manifestation of two different types of generation mechanisms for the induced magnetosphere. A different magnetic field topology (toroidal and poloidal) arises if the induced currents are driven either by the solar wind motional electric field or by the Faraday electric field—a conducting ionosphere sees the magnetic field carried by solar wind as a time-varying field. At the dayside, both driving agents produce a similar draping pattern of the magnetic field. However, different magnetic field signatures inherent to both induction mechanisms appear at lower altitudes in the terminator region. The conditions at low solar EUV flux when the ionosphere of Venus becomes magnetized seem to be favorable to distinguish between two different types of the induced fields. We present cases of both types of the magnetic field topology. The cases when the effects of the Faraday induction become well noticeable are especially interesting since they provide us with an example of solar wind interaction with a tiny induced dipole field immersed into the ionosphere. Another interesting case when poloidal magnetic fields are evidently displayed is observed when the IMF vector is almost aligned with the solar wind velocity. In general case, both mechanisms of induction probably complement each other.

  18. Worming Their Way into Shape: Toroidal Formations in Micellar Solutions

    Energy Technology Data Exchange (ETDEWEB)

    Cardiel Rivera, Joshua J.; Tonggu, Lige; Dohnalkova, Alice; de la Iglesia, Pablo; Pozzo, Danilo C.; Shen, Amy

    2013-11-01

    We report the formation of nanostructured toroidal micellar bundles (nTMB) from a semidilute wormlike micellar solution, evidenced by both cryogenicelectron microscopy and transmission electron microscopy images. Our strategy for creating nTMB involves a two-step protocol consisting of a simple prestraining process followed by flow through a microfluidic device containing an array of microposts, producing strain rates in the wormlike micelles on the order of 105 s^1. In combination with microfluidic confinement, these unusually large strain rates allow for the formation of stable nTMB. Electron microscopy images reveal a variety of nTMB morphologies and provide the size distribution of the nTMB. Small-angle neutron scattering indicates the underlying microstructural transition from wormlike micelles to nTMB. We also show that other flow-induced approaches such as sonication can induce and control the emergence of onion-like and nTMB structures, which may provide a useful tool for nanotemplating.

  19. Behavior of Compact Toroid in the External Magnetic Fields

    Science.gov (United States)

    Fukumoto, N.; Ioroi, A.; Nagata, M.; Uyama, T.

    1999-11-01

    We have investigated the possibility of refueling and density control of tokamak plasmas by the spheromak-type Compact Toroid (CT) injection in the JFT-2M tokamak in collaboration with JAERI. We demonstrated the CT injection into OH plasmas and observed the core penetration at B_T=0.8 T. The tokamak electron density increased ~0.2× 10^19m-3 at a rate of 2× 10^21m-3/s. We also observed the decrease of the CT velocity by the external magnetic field of the tokamak, which is applied across the CT acceleration region. We have examined the behavior of the CT translated in the external fields B_ext using the magnetic probes and the fast framing camera at Himeji Inst. of tech.. CT plasma in the acceleration region is deformed by the Lorentz force of Jg × B_ext, where Jg is the gun current for CT acceleration. The magnetic field structures of a long CT in the drift region has been revealed to be the mixed relaxed state of m=0 and m=1. Results from CT acceleration and injection in a transverse field will be presented.

  20. Deconfinement in Yang-Mills Theory through Toroidal Compactification

    Energy Technology Data Exchange (ETDEWEB)

    Simic, Dusan; Unsal, Mithat; /Stanford U., Phys. Dept. /SLAC

    2011-08-12

    We introduce field theory techniques through which the deconfinement transition of four-dimensional Yang-Mills theory can be moved to a semi-classical domain where it becomes calculable using two-dimensional field theory. We achieve this through a double-trace deformation of toroidally compactified Yang-Mills theory on R{sup 2} x S{sub L}{sup 1} x S{sub {beta}}{sup 1}. At large N, fixed-L, and arbitrary {beta}, the thermodynamics of the deformed theory is equivalent to that of ordinary Yang-Mills theory at leading order in the large N expansion. At fixed-N, small L and a range of {beta}, the deformed theory maps to a two-dimensional theory with electric and magnetic (order and disorder) perturbations, analogs of which appear in planar spin-systems and statistical physics. We show that in this regime the deconfinement transition is driven by the competition between electric and magnetic perturbations in this two-dimensional theory. This appears to support the scenario proposed by Liao and Shuryak regarding the magnetic component of the quark-gluon plasma at RHIC.

  1. Multiple-applications of Accelerated Compact Toroid Injection for MFE

    Science.gov (United States)

    Hwang, David; Horton, Robert; Evans, Russell; Liu, Fei; Zhu, Ben; Hong, Sean; Buchenauer, Dean

    2010-11-01

    The CTIX experiment has explored the potential applications of launching a fast moving magnetized compact toroid for Magnetic Fusion experiments. These applications include central fueling of a MFE device such as tokamaks, stellarators, etc. At present, the UC Davis CTIX accelerator has achieved densities at mid to upper 10^15 per cc, at speeds reaching over 200 km/sec. In order to meet the parameters of even larger fusion devices, the technology of the accelerator needs to incorporate the latest plasma wall interaction findings. As a result of the next step in CT development, UC Davis will be collaborating with the Fusion Technology group at Sandia National Laboratory in Livermore California. We will be designing new plasmas facing electrodes that can reduce electrode impurities and increase electrode lifetime. In addition to producing high density CTs, we will include the updated conical compression results from our previous installed drift section compressor. In addition of the MFE applications, the ability to enhance the CT density, fields as well as speed can be useful to other fusion areas such as MIF, etc.

  2. Pareto optimal design of sectored toroidal superconducting magnet for SMES

    Science.gov (United States)

    Bhunia, Uttam; Saha, Subimal; Chakrabarti, Alok

    2014-10-01

    A novel multi-objective optimization design approach for sectored toroidal superconducting magnetic energy storage coil has been developed considering the practical engineering constraints. The objectives include the minimization of necessary superconductor length and torus overall size or volume, which determines a significant part of cost towards realization of SMES. The best trade-off between the necessary conductor length for winding and magnet overall size is achieved in the Pareto-optimal solutions, the compact magnet size leads to increase in required superconducting cable length or vice versa The final choice among Pareto optimal configurations can be done in relation to other issues such as AC loss during transient operation, stray magnetic field at outside the coil assembly, and available discharge period, which is not considered in the optimization process. The proposed design approach is adapted for a 4.5 MJ/1 MW SMES system using low temperature niobium-titanium based Rutherford type cable. Furthermore, the validity of the representative Pareto solutions is confirmed by finite-element analysis (FEA) with a reasonably acceptable accuracy.

  3. Electron cyclotron heating and current drive in toroidal geometry

    Energy Technology Data Exchange (ETDEWEB)

    Kritz, A.H.

    1991-11-01

    The Principal Investigator has continued to work on problems associated both with the deposition and with the emission of electron cyclotron power in toroidal plasmas. We have investigated the use of electron cyclotron resonance heating for bringing compact tokamaks (BPX) to ignition-like parameters. This requires that we continue to refine the modeling capability of the TORCH code linked with the BALDUR 1 {1/2} D transport code. Using this computational tool, we have examined the dependence of ignition on heating and transport employing both theoretical (multi-mode) and empirically based transport models. The work on current drive focused on the suppression of tearing modes near the q = 2 surface and sawteeth near the q = 1 surface. Electron cyclotron current drive in CIT near the q =2 surface was evaluated for a launch scenario where electron cyclotron power was launched near the equatorial plane. The work on suppression of sawteeth has been oriented toward understanding the suppression that has been observed in a number of tokamaks, in particular, in the WT-3 tokamak in Kyoto. To evaluate the changes in current profile (shear) near the q =1 surface, simulations have been carried out using the linked BALDUR-TORCH code. We consider effects on shear resulting both from wave-induced current as well as from changes in conductivity associated with changes in local temperature. Abstracts and a paper relating to this work is included in Appendix A.

  4. First qualification of ITER Toroidal Field Coil conductor jacketing

    Energy Technology Data Exchange (ETDEWEB)

    Hamada, Kazuya, E-mail: hamada.kazuya@jaea.go.jp [Japan Atomic Energy Agency (Japan); Takahashi, Yoshikazu; Isono, Takaaki; Nunoya, Yoshihiko; Matsui, Kunihiro; Kawano, Katsumi; Oshikiri, Masayuki; Tsutsumi, Fumiaki; Koizumi, Norikiyo; Nakajima, Hideo; Okuno, Kiyoshi [Japan Atomic Energy Agency (Japan); Matsuda, Hidemitsu; Yano, Yoshitaka [Nippon Steel Engineering Co. Ltd (Japan); Devred, Arnauld; Bessette, Denis [ITER Organization (France)

    2011-10-15

    The Japan Atomic Energy Agency (JAEA) has the responsibility to procure 25% of the ITER Toroidal Field Coil conductors as the Japanese Domestic Agency (JADA) in the ITER project. The TF conductor is a circular shaped, cable-in-conduit conductor, composed of a cable and a stainless steel conduit (jacket). The outer diameter and maximum length of the TF conductor are 43.7 mm and 760 m, respectively. JAEA started to produce strand, cables and jacket sections and to construct a conductor manufacturing (jacketing) facility in 2008. Following preparation in December 2009 of the jacketing facility, the dummy cable, the jacket sections and fabrication procedures, such as welding, cable insertion, compaction and spooling, JAEA manufactured a 760 m long Cu dummy conductor for process qualification. Into the 760 m long Cu dummy conductor jacketing, JAEA successfully inserted the cable with a maximum force of 32 kN. The outer diameter of the cross section of the spooled conductor was 43.7 {+-} 0.15 mm, which complies with the ITER target requirement of 43.7 {+-} 0.3 mm. Following qualification of all manufacturing processes, JAEA has started to fabricate superconducting conductors for the TF coils.

  5. Overexpression of eIF5 or its protein mimic 5MP perturbs eIF2 function and induces ATF4 translation through delayed re-initiation

    Science.gov (United States)

    Kozel, Caitlin; Thompson, Brytteny; Hustak, Samantha; Moore, Chelsea; Nakashima, Akio; Singh, Chingakham Ranjit; Reid, Megan; Cox, Christian; Papadopoulos, Evangelos; Luna, Rafael E.; Anderson, Abbey; Tagami, Hideaki; Hiraishi, Hiroyuki; Slone, Emily Archer; Yoshino, Ken-ichi; Asano, Masayo; Gillaspie, Sarah; Nietfeld, Jerome; Perchellet, Jean-Pierre; Rothenburg, Stefan; Masai, Hisao; Wagner, Gerhard; Beeser, Alexander; Kikkawa, Ushio; Fleming, Sherry D.; Asano, Katsura

    2016-01-01

    ATF4 is a pro-oncogenic transcription factor whose translation is activated by eIF2 phosphorylation through delayed re-initiation involving two uORFs in the mRNA leader. However, in yeast, the effect of eIF2 phosphorylation can be mimicked by eIF5 overexpression, which turns eIF5 into translational inhibitor, thereby promoting translation of GCN4, the yeast ATF4 equivalent. Furthermore, regulatory protein termed eIF5-mimic protein (5MP) can bind eIF2 and inhibit general translation. Here, we show that 5MP1 overexpression in human cells leads to strong formation of 5MP1:eIF2 complex, nearly comparable to that of eIF5:eIF2 complex produced by eIF5 overexpression. Overexpression of eIF5, 5MP1 and 5MP2, the second human paralog, promotes ATF4 expression in certain types of human cells including fibrosarcoma. 5MP overexpression also induces ATF4 expression in Drosophila. The knockdown of 5MP1 in fibrosarcoma attenuates ATF4 expression and its tumor formation on nude mice. Since 5MP2 is overproduced in salivary mucoepidermoid carcinoma, we propose that overexpression of eIF5 and 5MP induces translation of ATF4 and potentially other genes with uORFs in their mRNA leaders through delayed re-initiation, thereby enhancing the survival of normal and cancer cells under stress conditions. PMID:27325740

  6. First End Cap Toroid knocking on the door of SX1

    CERN Multimedia

    Herman Ten Kate

    On Tuesday May 29, the first Toroid End Cap for the A-side was transported from its test station next to B180 to the front of the ATLAS surface building SX1. The 240-ton and 12-m high toroid end-cap moved on a special trailer at walking speed, got over various slopes and survived the difficult turn left in front of the entrance at gate B. The toroid had to wait for almost two months to commence its journey to its destination as the cryogenic test down to 80K was already successfully completed by early April. In the next days, the toroid will slide into the SX1 building, turn around its axes by 90 degrees and then gently slide over the first shaft and land on top of the A-side shaft on Wednesday. There, it will descend by 5 m into the shaft using special lifting tooling before it can be connected to the 2x140 tons overhead cranes which will let the toroid go further down to the cavern. End Cap Toroid A on the trailer on its way to the cavern at Point 1. Crossing the main road near entrance A while t...

  7. Role of ATF7-TAF12 interactions in the VDR hyper-sensitivity of osteoclast precursors in Paget’s disease

    Science.gov (United States)

    Teramachi, Jumpei; Hiruma, Yuko; Ishizuka, Seiichi; Ishizuka, Hisako; Brown, Jacques P.; Michou, Laëtitia; Cao, Huiling; Galson, Deborah L; Subler, Mark A; Zhou, Hua; Dempster, David W; Windle, Jolene J; Roodman, G. David; Kurihara, Noriyoshi

    2013-01-01

    Osteoclast (OCL) precursors from many Paget's disease (PD) patients express measles virus nucleocapsid protein (MVNP) and are hypersensitive to 1,25-(OH)2D3. The increased 1,25-(OH)2D3 sensitivity is mediated by TAF12, a co-activator of VDR, which is present at much higher levels in MVNP-expressing OCL precursors than normals. These results suggest that TAF12 plays an important role in the abnormal OCL activity in PD. However, the molecular mechanisms underlying both 1,25-(OH)2D3’s effects on OCL formation and the contribution of TAF12 to these effects in both normals and PD patients are unclear. Inhibition of TAF12 with a specific TAF12 antisense construct decreased OCL formation and OCL precursors sensitivity to 1,25-(OH)2D3 in PD patient bone marrow samples. Further, OCL-precursors from transgenic mice in which TAF12 expression was targeted to the OCL lineage (TRAP-TAF12 mice), formed OCL at very low levels of 1,25-(OH)2D3, although the OCL failed to exhibit other hallmarks of PD OCL, including RANKL hyper-sensitivity and hyper-multinucleation. ChIP analysis of OCL precursors using an anti-TAF12 antibody demonstrated that TAF12 binds the 24-hydroxylase (CYP24A1) promoter, which contains two functional vitamin D response elements (VDRE), in the presence of 1,25-(OH)2D3. Since TAF12 directly interacts with the ATF7 transcription factor and potentiates ATF7-induced transcriptional activation of ATF7-driven genes in other cell types, we determined if TAF12 is a functional partner of ATF7 in OCL precursors. Immunoprecipitation of lysates from either WT or MVNP-expressing OCL with an anti-TAF12 antibody followed by blotting with an anti-ATF7 antibody, or vice versa, showed that TAF12 and ATF7 physically interact in OCL. Knockdown of ATF7 in MVNP-expressing cells decreased CYP24A1 induction by 1,25-(OH)2D3 as well as TAF12 binding to the CYP24A1 promoter. These results show that ATF7 interacts with TAF12 and contributes to the hyper-sensitivity of OCL precursors to 1

  8. Parkin is transcriptionally regulated by ATF4: evidence for an interconnection between mitochondrial stress and ER stress.

    Science.gov (United States)

    Bouman, L; Schlierf, A; Lutz, A K; Shan, J; Deinlein, A; Kast, J; Galehdar, Z; Palmisano, V; Patenge, N; Berg, D; Gasser, T; Augustin, R; Trümbach, D; Irrcher, I; Park, D S; Wurst, W; Kilberg, M S; Tatzelt, J; Winklhofer, K F

    2011-05-01

    Loss of parkin function is responsible for the majority of autosomal recessive parkinsonism. Here, we show that parkin is not only a stress-protective, but also a stress-inducible protein. Both mitochondrial and endoplasmic reticulum (ER) stress induce an increase in parkin-specific mRNA and protein levels. The stress-induced upregulation of parkin is mediated by ATF4, a transcription factor of the unfolded protein response (UPR) that binds to a specific CREB/ATF site within the parkin promoter. Interestingly, c-Jun can bind to the same site, but acts as a transcriptional repressor of parkin gene expression. We also present evidence that mitochondrial damage can induce ER stress, leading to the activation of the UPR, and thereby to an upregulation of parkin expression. Vice versa, ER stress results in mitochondrial damage, which can be prevented by parkin. Notably, the activity of parkin to protect cells from stress-induced cell death is independent of the proteasome, indicating that proteasomal degradation of parkin substrates cannot explain the cytoprotective activity of parkin. Our study supports the notion that parkin has a role in the interorganellar crosstalk between the ER and mitochondria to promote cell survival under stress, suggesting that both ER and mitochondrial stress can contribute to the pathogenesis of Parkinson's disease.

  9. Opportunities for the LWR ATF materials development program to contribute to the LBE-cooled ADS materials qualification program

    Science.gov (United States)

    Gong, Xing; Li, Rui; Sun, Maozhou; Ren, Qisen; Liu, Tong; Short, Michael P.

    2016-12-01

    Accelerator-driven systems (ADS) are a promising approach for nuclear waste disposal. Nevertheless, the principal candidate materials proposed for ADS construction, such as the ferritic/martensitic steel, T91, and austenitic stainless steels, 316L and 15-15Ti, are not fully compatible with the liquid lead-bismuth eutectic (LBE) coolant. Under some operating conditions, liquid metal embrittlement (LME) or liquid metal corrosion (LMC) may occur in these steels when exposed to LBE. These environmentally-induced material degradation effects pose a threat to ADS reactor safety, as failure of the materials could initiate a severe accident, in which fission products are released into the coolant. Meanwhile, parallel efforts to develop accident-tolerant fuels (ATF) in light water reactors (LWRs) could provide both general materials design philosophies and specific material solutions to the ADS program. In this paper, the potential contributions of the ATF materials development program to the ADS materials qualification program are evaluated and discussed in terms of service conditions and materials performance requirements. Several specific areas where coordinated development may benefit both programs, including composite materials and selected coatings, are discussed.

  10. Inductive Eigenmodes of a resistive toroidal surface in vacuum

    Energy Technology Data Exchange (ETDEWEB)

    Lo Surdo, C. [ENEA, Centro Ricerche Frascati, Rome (Italy). Dipt. Innovazione

    1999-07-01

    In this paper it has been studied the Electro-Magnetic (EM) Eigenmodes, sufficiently slow as to legitimate the pre-Maxwell approximation of Maxwell's system (or inductive Eigenmodes), of a given smooth, toroidal-un knotted, electrically resistive surface {tau} with given smooth (surface) resistivity 0 < {rho}{sub d}egree < {infinity}, and lying in the (empty) R{sup 3}. Within the above limitations (to be made more precise), the geometry of {tau} is arbitrary. With the eigenvalue associated with the generic Eigenmode being defined as the opposite of its logarithmic time-derivative, one expects that the resulting spectrum be discrete and strictly positive. It shall be interested into the degenerate case where {tau} be cut (i.e. electrically broken) along one or more of its irreducible cycles. This case will be analyzed autonomously, rather than as a limit (for {rho}{sub d}egree {yields} {infinity} along the cuts) of the regular case. Without cuts, the Eigenproblem under consideration is nothing but the two-dimensional (2-dim) generalization of the classical case of a smooth, unknotted, electrically conductive, simple coil in infinite vacuum. Its analysis hinges on the classical potential theory, and turns out to be a special application of the linear, integrodifferential (elliptic) equation theory on a compact, multiply connected, 2-dim manifold. The attention and approach will be confined to strong (or classical) solutions, both in {tau} and C {tau} = R{sup 3} / {tau}. This study is divided in two parts: a General Part (Sects 1 divided 4) is devoted to the case of generic {tau} and {rho}{sub d}egree (within the convenient smoothness requirements), whereas a Special Part (Sects 5 divided 7) deals with the (more or less formal) discussion of a couple of particular cases ({tau} {identical_to} a canonical torus), both of which with uniform {rho}{sub d}egree. Some propaedeutical/supplementary information is provided in a number of Appendices. [Italian] Il presente

  11. Transport bifurcation induced by sheared toroidal flow in tokamak plasmasa)

    Science.gov (United States)

    Highcock, E. G.; Barnes, M.; Parra, F. I.; Schekochihin, A. A.; Roach, C. M.; Cowley, S. C.

    2011-10-01

    First-principles numerical simulations are used to describe a transport bifurcation in a differentially rotating tokamak plasma. Such a bifurcation is more probable in a region of zero magnetic shear than one of finite magnetic shear, because in the former case the component of the sheared toroidal flow that is perpendicular to the magnetic field has the strongest suppressing effect on the turbulence. In the zero-magnetic-shear regime, there are no growing linear eigenmodes at any finite value of flow shear. However, subcritical turbulence can be sustained, owing to the existence of modes, driven by the ion temperature gradient and the parallel velocity gradient, which grow transiently. Nonetheless, in a parameter space containing a wide range of temperature gradients and velocity shears, there is a sizeable window where all turbulence is suppressed. Combined with the relatively low transport of momentum by collisional (neoclassical) mechanisms, this produces the conditions for a bifurcation from low to high temperature and velocity gradients. A parametric model is constructed which accurately describes the combined effect of the temperature gradient and the flow gradient over a wide range of their values. Using this parametric model, it is shown that in the reduced-transport state, heat is transported almost neoclassically, while momentum transport is dominated by subcritical parallel-velocity-gradient-driven turbulence. It is further shown that for any given input of torque, there is an optimum input of heat which maximises the temperature gradient. The parametric model describes both the behaviour of the subcritical turbulence (which cannot be modelled by the quasi-linear methods used in current transport codes) and the complicated effect of the flow shear on the transport stiffness. It may prove useful for transport modelling of tokamaks with sheared flows.

  12. First-principles approach to investigate toroidal property of magnetoelectric multiferroic GaFeO{sub 3}

    Energy Technology Data Exchange (ETDEWEB)

    Nie, Yung-mau, E-mail: ymnie@ncnu.edu.tw [Department of Applied Materials and Optoelectronic Engineering, National Chi Nan University (NCNU), Nantou County 54561, Taiwan (China)

    2016-01-14

    A first-principles approach incorporating the concept of toroidal moments as a measure of the spin vortex is proposed and applied to simulate the toroidization of magnetoelectric multiferroic GaFeO{sub 3}. The nature of space-inversion and time-reversal violations of ferrotoroidics is reproduced in the simulated magnetic structure of GaFeO{sub 3}. For undoped GaFeO{sub 3}, a toroidal moment of −22.38 μ{sub B} Å per unit cell was obtained, which is the best theoretical estimate till date. Guided by the spin vortex free-energy minimization perturbed by an externally applied field, it was discovered that the minority spin markedly biases the whole toroidization. In summary, this approach not only calculates the toroidal moment but provides a way to understand the toroidal nature of magnetoelectric multiferroics.

  13. Validation of improved Multi-Mode model for density, temperature and toroidal rotation profiles using PTRANSP simulations

    Science.gov (United States)

    Luo, L.; Bateman, G.; Kritz, A. H.; Pankin, A. Y.; Rafiq, T.; McCune, D. C.; Budny, R. V.

    2010-11-01

    Advances in the Multi-Mode model include an improved Weiland model for the ITG and TEM modes [1] and a new model for the drift resistive inertial ballooning modes (DRIBM) [2]. Advances in the PTRANSP code include an improved algorithm for the particle density evolution. Validation studies are carried out for the improved Multi-Mode model using PTRANSP simulations. In order to allow tight coupling with stiff transport models, all of the transport equations for main ion and impurity density profiles as well as electron temperature, ion temperature and toroidal angular rotation profiles are advanced simultaneously by the PTRANSP solver. The Plasma State connects the new solver to the rest of PTRANSP. The solver uses several techniques to control numerical stability. Simulation results for density, temperature and rotation frequency profiles are compared with experimental data for L-mode and H-mode discharges. [4pt] [1] J.Weiland et al., Nucl. Fusion 49 (2009) 965933; F.D. Halpern et al., Phys. Plasmas 15 (2008) 065033 [2] T. Rafiq et al., to appear in Phys. Plasmas (2010)

  14. Development of toroid-type HTS DC reactor series for HVDC system

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Kwangmin, E-mail: kwangmin81@gmail.com [Changwon National University, 55306 Sarim-dong, Changwon 641-773 (Korea, Republic of); Go, Byeong-Soo; Park, Hea-chul; Kim, Sung-kyu; Kim, Seokho [Changwon National University, 55306 Sarim-dong, Changwon 641-773 (Korea, Republic of); Lee, Sangjin [Uiduk University, Gyeongju 780-713 (Korea, Republic of); Oh, Yunsang [Vector Fields Korea Inc., Pohang 790-834 (Korea, Republic of); Park, Minwon; Yu, In-Keun [Changwon National University, 55306 Sarim-dong, Changwon 641-773 (Korea, Republic of)

    2015-11-15

    Highlights: • The authors developed the 400 mH, 400 A class toroid-type HTS DC reactor system. • The target temperature, inductance and operating current are under 20 K at magnet, 400 mH and 400 A, respectively. All target performances of the HTS DC reactor were achieved. • The HTS DC reactor was conducted through the interconnection operation with a LCC type HVDC system. • Now, the authors are studying the 400 mH, 1500 A class toroid-type HTS DC reactor for the next phase HTS DC reactor. - Abstract: This paper describes design specifications and performance of a toroid-type high-temperature superconducting (HTS) DC reactor. The first phase operation targets of the HTS DC reactor were 400 mH and 400 A. The authors have developed a real HTS DC reactor system during the last three years. The HTS DC reactor was designed using 2G GdBCO HTS wires. The HTS coils of the toroid-type DC reactor magnet were made in the form of a D-shape. The electromagnetic performance of the toroid-type HTS DC reactor magnet was analyzed using the finite element method program. A conduction cooling method was adopted for reactor magnet cooling. The total system has been successfully developed and tested in connection with LCC type HVDC system. Now, the authors are studying a 400 mH, kA class toroid-type HTS DC reactor for the next phase research. The 1500 A class DC reactor system was designed using layered 13 mm GdBCO 2G HTS wire. The expected operating temperature is under 30 K. These fundamental data obtained through both works will usefully be applied to design a real toroid-type HTS DC reactor for grid application.

  15. Hepatic maturation of human iPS cell-derived hepatocyte-like cells by ATF5, c/EBPα, and PROX1 transduction.

    Science.gov (United States)

    Nakamori, Daiki; Takayama, Kazuo; Nagamoto, Yasuhito; Mitani, Seiji; Sakurai, Fuminori; Tachibana, Masashi; Mizuguchi, Hiroyuki

    2016-01-15

    Hepatocyte-like cells differentiated from human iPS cells (human iPS-HLCs) are expected to be utilized in drug development and research. However, recent hepatic characterization of human iPS-HLCs showed that these cells resemble fetal hepatocytes rather than adult hepatocytes. Therefore, in this study, we aimed to develop a method to enhance the hepatic function of human iPS-HLCs. Because the gene expression levels of the hepatic transcription factors (activating transcription factor 5 (ATF5), CCAAT/enhancer-binding protein alpha (c/EBPα), and prospero homeobox protein 1 (PROX1)) in adult liver were significantly higher than those in human iPS-HLCs and fetal liver, we expected that the hepatic functions of human iPS-HLCs could be enhanced by adenovirus (Ad) vector-mediated ATF5, c/EBPα, and PROX1 transduction. The gene expression levels of cytochrome P450 (CYP) 2C9, 2E1, alpha-1 antitrypsin, transthyretin, Na+/taurocholate cotransporting polypeptide, and uridine diphosphate glucuronosyl transferase 1A1 and protein expression levels of CYP2C9 and CYP2E1 were upregulated by ATF5, c/EBPα, and PROX1 transduction. These results suggest that the hepatic functions of the human iPS-HLCs could be enhanced by ATF5, c/EBPα, and PROX1 transduction. Our findings would be useful for the hepatic maturation of human iPS-HLCs.

  16. The response of the prostate to circulating cholesterol: activating transcription factor 3 (ATF3 as a prominent node in a cholesterol-sensing network.

    Directory of Open Access Journals (Sweden)

    Jayoung Kim

    Full Text Available Elevated circulating cholesterol is a systemic risk factor for cardiovascular disease and metabolic syndrome, however the manner in which the normal prostate responds to variations in cholesterol levels is poorly understood. In this study we addressed the molecular and cellular effects of elevated and suppressed levels of circulating cholesterol on the normal prostate. Integrated bioinformatic analysis was performed using DNA microarray data from two experimental formats: (1 ventral prostate from male mice with chronically elevated circulating cholesterol and (2 human prostate cells exposed acutely to cholesterol depletion. A cholesterol-sensitive gene expression network was constructed from these data and the transcription factor ATF3 was identified as a prominent node in the network. Validation experiments confirmed that elevated cholesterol reduced ATF3 expression and enhanced proliferation of prostate cells, while cholesterol depletion increased ATF3 levels and inhibited proliferation. Cholesterol reduction in vivo alleviated dense lymphomononuclear infiltrates in the periprostatic adipose tissue, which were closely associated with nerve tracts and blood vessels. These findings open new perspectives on the role of cholesterol in prostate health, and provide a novel role for ATF3, and associated proteins within a large signaling network, as a cholesterol-sensing mechanism.

  17. Amino acid availability controls TRB3 transcription in liver through the GCN2/eIF2α/ATF4 pathway.

    Directory of Open Access Journals (Sweden)

    Valérie Carraro

    Full Text Available In mammals, plasma amino acid concentrations are markedly affected by dietary or pathological conditions. It has been well established that amino acids are involved in the control of gene expression. Up to now, all the information concerning the molecular mechanisms involved in the regulation of gene transcription by amino acid availability has been obtained in cultured cell lines. The present study aims to investigate the mechanisms involved in transcriptional activation of the TRB3 gene following amino acid limitation in mice liver. The results show that TRB3 is up-regulated in the liver of mice fed a leucine-deficient diet and that this induction is quickly reversible. Using transient transfection and chromatin immunoprecipitation approaches in hepatoma cells, we report the characterization of a functional Amino Acid Response Element (AARE in the TRB3 promoter and the binding of ATF4, ATF2 and C/EBPβ to this AARE sequence. We also provide evidence that only the binding of ATF4 to the AARE plays a crucial role in the amino acid-regulated transcription of TRB3. In mouse liver, we demonstrate that the GCN2/eIF2α/ATF4 pathway is essential for the induction of the TRB3 gene transcription in response to a leucine-deficient diet. Therefore, this work establishes for the first time that the molecular mechanisms involved in the regulation of gene transcription by amino acid availability are functional in mouse liver.

  18. Development of toroid-type HTS DC reactor series for HVDC system

    Science.gov (United States)

    Kim, Kwangmin; Go, Byeong-Soo; Park, Hea-chul; Kim, Sung-kyu; Kim, Seokho; Lee, Sangjin; Oh, Yunsang; Park, Minwon; Yu, In-Keun

    2015-11-01

    This paper describes design specifications and performance of a toroid-type high-temperature superconducting (HTS) DC reactor. The first phase operation targets of the HTS DC reactor were 400 mH and 400 A. The authors have developed a real HTS DC reactor system during the last three years. The HTS DC reactor was designed using 2G GdBCO HTS wires. The HTS coils of the toroid-type DC reactor magnet were made in the form of a D-shape. The electromagnetic performance of the toroid-type HTS DC reactor magnet was analyzed using the finite element method program. A conduction cooling method was adopted for reactor magnet cooling. The total system has been successfully developed and tested in connection with LCC type HVDC system. Now, the authors are studying a 400 mH, kA class toroid-type HTS DC reactor for the next phase research. The 1500 A class DC reactor system was designed using layered 13 mm GdBCO 2G HTS wire. The expected operating temperature is under 30 K. These fundamental data obtained through both works will usefully be applied to design a real toroid-type HTS DC reactor for grid application.

  19. Quantum field theory on toroidal topology: Algebraic structure and applications

    Science.gov (United States)

    Khanna, F. C.; Malbouisson, A. P. C.; Malbouisson, J. M. C.; Santana, A. E.

    2014-05-01

    The development of quantum theory on a torus has a long history, and can be traced back to the 1920s, with the attempts by Nordström, Kaluza and Klein to define a fourth spatial dimension with a finite size, being curved in the form of a torus, such that Einstein and Maxwell equations would be unified. Many developments were carried out considering cosmological problems in association with particle physics, leading to methods that are useful for areas of physics, in which size effects play an important role. This interest in finite size effect systems has been increasing rapidly over the last decades, due principally to experimental improvements. In this review, the foundations of compactified quantum field theory on a torus are presented in a unified way, in order to consider applications in particle and condensed matter physics. The theory on a torus ΓDd=(S1)d×RD-d is developed from a Lie-group representation and c*c*-algebra formalisms. As a first application, the quantum field theory at finite temperature, in its real- and imaginary-time versions, is addressed by focusing on its topological structure, the torus Γ41. The toroidal quantum-field theory provides the basis for a consistent approach of spontaneous symmetry breaking driven by both temperature and spatial boundaries. Then the superconductivity in films, wires and grains are analyzed, leading to some results that are comparable with experiments. The Casimir effect is studied taking the electromagnetic and Dirac fields on a torus. In this case, the method of analysis is based on a generalized Bogoliubov transformation, that separates the Green function into two parts: one is associated with the empty space-time, while the other describes the impact of compactification. This provides a natural procedure for calculating the renormalized energy-momentum tensor. Self interacting four-fermion systems, described by the Gross-Neveu and Nambu-Jona-Lasinio models, are considered. Then finite size effects on

  20. Identification and Small Molecule Inhibition of an Activating Transcription Factor 4 (ATF4)-dependent Pathway to Age-related Skeletal Muscle Weakness and Atrophy*

    Science.gov (United States)

    Ebert, Scott M.; Dyle, Michael C.; Bullard, Steven A.; Dierdorff, Jason M.; Murry, Daryl J.; Fox, Daniel K.; Bongers, Kale S.; Lira, Vitor A.; Meyerholz, David K.; Talley, John J.; Adams, Christopher M.

    2015-01-01

    Aging reduces skeletal muscle mass and strength, but the underlying molecular mechanisms remain elusive. Here, we used mouse models to investigate molecular mechanisms of age-related skeletal muscle weakness and atrophy as well as new potential interventions for these conditions. We identified two small molecules that significantly reduce age-related deficits in skeletal muscle strength, quality, and mass: ursolic acid (a pentacyclic triterpenoid found in apples) and tomatidine (a steroidal alkaloid derived from green tomatoes). Because small molecule inhibitors can sometimes provide mechanistic insight into disease processes, we used ursolic acid and tomatidine to investigate the pathogenesis of age-related muscle weakness and atrophy. We found that ursolic acid and tomatidine generate hundreds of small positive and negative changes in mRNA levels in aged skeletal muscle, and the mRNA expression signatures of the two compounds are remarkably similar. Interestingly, a subset of the mRNAs repressed by ursolic acid and tomatidine in aged muscle are positively regulated by activating transcription factor 4 (ATF4). Based on this finding, we investigated ATF4 as a potential mediator of age-related muscle weakness and atrophy. We found that a targeted reduction in skeletal muscle ATF4 expression reduces age-related deficits in skeletal muscle strength, quality, and mass, similar to ursolic acid and tomatidine. These results elucidate ATF4 as a critical mediator of age-related muscle weakness and atrophy. In addition, these results identify ursolic acid and tomatidine as potential agents and/or lead compounds for reducing ATF4 activity, weakness, and atrophy in aged skeletal muscle. PMID:26338703

  1. Taxol-induced unfolded protein response activation in breast cancer cells exposed to hypoxia: ATF4 activation regulates autophagy and inhibits apoptosis.

    Science.gov (United States)

    Notte, Annick; Rebucci, Magali; Fransolet, Maude; Roegiers, Edith; Genin, Marie; Tellier, Celine; Watillon, Kassandra; Fattaccioli, Antoine; Arnould, Thierry; Michiels, Carine

    2015-05-01

    Understanding the mechanisms responsible for the resistance against chemotherapy-induced cell death is still of great interest since the number of patients with cancer increases and relapse is commonly observed. Indeed, the development of hypoxic regions as well as UPR (unfolded protein response) activation is known to promote cancer cell adaptive responses to the stressful tumor microenvironment and resistance against anticancer therapies. Therefore, the impact of UPR combined to hypoxia on autophagy and apoptosis activation during taxol exposure was investigated in MDA-MB-231 and T47D breast cancer cells. The results showed that taxol rapidly induced UPR activation and that hypoxia modulated taxol-induced UPR activation differently according to the different UPR pathways (PERK, ATF6, and IRE1α). The putative involvement of these signaling pathways in autophagy or in apoptosis regulation in response to taxol exposure was investigated. However, while no link between the activation of these three ER stress sensors and autophagy or apoptosis regulation could be evidenced, results showed that ATF4 activation, which occurs independently of UPR activation, was involved in taxol-induced autophagy completion. In addition, an ATF4-dependent mechanism leading to cancer cell adaptation and resistance against taxol-induced cell death was evidenced. Finally, our results demonstrate that expression of ATF4, in association with hypoxia-induced genes, can be used as a biomarker of a poor prognosis for human breast cancer patients supporting the conclusion that ATF4 might play an important role in adaptation and resistance of breast cancer cells to chemotherapy in hypoxic tumors.

  2. Development of a Turn-by-Turn Beam Position Monitoring System for Multiple Bunch Operation of the ATF Damping Ring

    CERN Document Server

    Burrows, P N; Kraljevic, N Blaskovic; Christian, G B; Davis, M R; Perry, C; Apsimon, R J; Constance, B; Gerbershagen, A; Resta-Lopez, J

    2012-01-01

    An FPGA-based monitoring system has been developed to study multi-bunch beam instabilities in the damping ring (DR) of the KEK Accelerator Test Facility (ATF). The system utilises a stripline beam position monitor (BPM) and single-stage down-mixing BPM processor. The system is designed to record the horizontal and/or vertical positions of up to three bunches in the DR with c. 150ns bunch spacing, or the head bunch of up to three trains in a multi-bunch mode with a bunch spacing of 5.6 ns. The FPGA firmware and data acquisition software allow the recording of turnby-turn data. An overview of the system and performance results will be presented.

  3. Finite beta and compressibility effects on stability of resistive modes in toroidal geometry

    Energy Technology Data Exchange (ETDEWEB)

    Leboeuf, J.-N.G. [Oak Ridge National Lab., TN (United States); Kurita, Gen-ichi

    1998-03-01

    Linear resistive stability results obtained from the toroidal magnetohydrodynamic codes FAR developed at the Oak Ridge National Laboratory in United States of America and AEOLUS developed at the Japan Atomic Energy Research Institute are compared for carefully constructed benchmark profiles and parameters. These are unstable to a tearing mode with toroidal mode number n=1. The eigenvalues and eigenfunctions calculated with both codes are in close agreement and show that the effect of compressibility is weak for these modes. The effect of finite plasma beta is considered, and the eigenvalues calculated by the FAR and AEOLUS codes also show good agreement. It is shown that the finite beta has a stabilizing effect on the toroidal tearing mode, but that the compressibility also has little effect on finite beta tearing modes. (author)

  4. Current transformers with nanocrystalline alloy toroidal core: analytical, computational and experimental studies

    Directory of Open Access Journals (Sweden)

    Benedito Antonio Luciano

    2012-10-01

    Full Text Available In this paper are presented theoretical analysis and experimental results concerning the performance of toroidal cores used in current transformers. For most problems concerning transformers design, analytical methods are useful, but numerical methods provide a better understanding of the transformers electromagnetic behaviour. Numerical field solutions may be used to determine the electrical equivalent circuit parameters of toroidal core current transformers. Since the exciting current of current transformers alters the ratio and phase angle of primary and secondary currents, it is made as small as possible though the use of high permeability and low loss magnetic material in the construction of the core. According to experimental results presented in this work, in comparison with others soft magnetic materials, nanocrystalline alloys appear as the best material to be used in toroidal core for current transformers.

  5. Observations of toroidicity-induced Alfvén eigenmodes in a reversed field pinch plasma

    Science.gov (United States)

    Regnoli, G.; Bergsâker, H.; Tennfors, E.; Zonca, F.; Martines, E.; Serianni, G.; Spolaore, M.; Vianello, N.; Cecconello, M.; Antoni, V.; Cavazzana, R.; Malmberg, J.-A.

    2005-04-01

    High frequency peaks in the spectra of magnetic field signals have been detected at the edge of Extrap-T2R [P. R. Brunsell, H. Bergsåker, M. Cecconello, J. R. Drake, R. M. Gravestijn, A. Hedqvist, and J.-A. Malmberg, Plasma Phys. Controlled Fusion, 43, 1457 (2001)]. The measured fluctuation is found to be mainly polarized along the toroidal direction, with high toroidal periodicity n and Alfvénic scaling (f∝B/√mini ). Calculations for a reversed field pinch plasma predict the existence of an edge resonant, high frequency, high-n number toroidicity-induced Alfvén eigenmode with the observed frequency scaling. In addition, gas puffing experiments show that edge density fluctuations are responsible for the rapid changes of mode frequency. Finally a coupling with the electron drift turbulence is proposed as drive mechanism for the eigenmode.

  6. Optimization of Shielded PCB Air-Core Toroids for High-Efficiency DC-DC Converters

    CERN Document Server

    Orlandi, S; Buso, S; Michelis, S; Fuentes, C A; Kayal, M; Faccio, F; Spiazzi, G

    2011-01-01

    The paper describes the design of optimized printed circuit board (PCB) air-core toroids for high-frequency dc-dc converters with strict requirements in terms of volume and noise. The effect of several design parameters on the overall inductor volume, on dc and ac winding resistance, and on the radiated noise will be investigated. PCB toroids are compared to standard air-core solenoids and other state-of-the-art air-core toroids both theoretically and experimentally: at first, using ANSOFT Maxwell and ANSOFT Q3D simulation tools, and subsequently, with laboratory measurements (irradiated noise, efficiency, and frequency response) on several prototypes. These very flexible and rather easy to manufacture inductors appear very attractive for compact high-frequency dc-dc converters where high efficiency, low volume, and low noise are of primary concern.

  7. A Generic Minimal Discrete Model for Toroidal Moments and Its Experimental Realization

    CERN Document Server

    Xiang, Hong; Liu, Liang; Jiang, Tianshu; Zhang, Z Q; Chan, C T; Han, Dezhuan

    2016-01-01

    It is well known that a closed loop of magnetic dipoles can give rise to the rather elusive toroidal moment. However, artificial structures required to generate the necessary magnetic moments are typically optically large, complex to make and easily compromised by the kinetic inductance at high frequencies. Instead of using magnetic dipoles, we propose a minimal model based on just three aligned discrete electric dipoles in which the occurrence of resonant toroidal modes is guaranteed by symmetry. The advantage of this model is its simplicity and the same model supports toroidal moments from the microwave regime up to optical frequencies as exemplified by a three-antenna array and a system consisting of three nano-sized plasmonic particles. Both the microwave and high-frequency configurations exhibit non-radiating "anapoles". Experiments in the microwave regime confirm the theoretical predictions.

  8. Magnetohydrodynamic calculations with a nonmonotonic q profile and equilibrium, sheared toroidal flow

    Energy Technology Data Exchange (ETDEWEB)

    Held, E.D. [Univ. of Wisconsin, Madison, WI (United States). Center for Plasma Theory and Computation; Leboeuf, J.N.; Carreras, B.A. [Oak Ridge National Lab., TN (United States). Fusion Energy Div.

    1998-07-01

    The linear and nonlinear stability of a nonmonotonic q profile is examined using a reduced set of magnetohydrodynamic (MHD) equations with an equilibrium, sheared toroidal flow. The reversed shear profile is shown to be unstable to a rich variety of resistive MHD modes including pressure-driven instabilities and tearing instabilities possessing a tearing/interchange character at low Lundquist number, S, and taking on a double/triple tearing structure at high S. Linear calculations show that the destabilizing effect of toroidal velocity shear on tearing modes is enhanced at finite pressure seen previously for tearing modes at high S. Nonlinear calculations show the generation of a large, m = 1, n = 0, Reynolds-stress-driven poloidal flow in the absence of significant flow damping. Calculations in which the poloidal flow was heavily damped show that sub-Alfvenic, sheared toroidal flows have a minimal effect on weakly-coupled, localized instabilities.

  9. Instability of Non-uniform Toroidal Magnetic Fields in Accretion Disks

    CERN Document Server

    Hirabayashi, Kota

    2016-01-01

    A new type of instability that is expected to drive magnetohydrodynamic (MHD) turbulence from a purely toroidal magnetic field in an accretion disk is presented. It is already known that in a differentially rotating system, the uniform toroidal magnetic field is unstable due to a magnetorotational instability (MRI) under a non-axisymmetric and vertical perturbation, while it is stable under a purely vertical perturbation. Contrary to the previous study, this paper proposes an unstable mode completely confined to the equatorial plane, driven by the expansive nature of the magnetic pressure gradient force under a non-uniform toroidal field. The basic nature of this growing eigenmode, to which we give a name "magneto-gradient driven instability", is studied using linear analysis, and the corresponding nonlinear evolution is then investigated using two-dimensional ideal MHD simulations. Although a single localized magnetic field channel alone cannot provide sufficient Maxwell stress to contribute significantly to...

  10. A toroidal vortex field as an origin of the narrow mass spectrum of neutron stars

    Science.gov (United States)

    Kontorovich, V. M.

    2016-03-01

    The evolution and collapse of a gaseous, self-gravitating sphere in the presence of an internal massive toroidal vortex analogous to the vortex created by the toroidal magnetic field of the Sun is considered. When thermal pressure is taken into account, for sufficiently high masses, the instability is preserved even for a polytropic index γ neutrons differs appreciably. In the ultrarelativistic limit, an interval of stablemasses arises in a neutron gas, between a minimum mass that depends on the circulation velocity in the vortex and the critical mass for the formation of a black hole. This suggests toroidal vortex fields as a possible physical origin for the observed narrow spectrum of neutron-star masses.

  11. Bifurcation to 3D Helical Magnetic Equilibrium in an Axisymmetric Toroidal Device

    Science.gov (United States)

    Bergerson, W. F.; Auriemma, F.; Chapman, B. E.; Ding, W. X.; Zanca, P.; Brower, D. L.; Innocente, P.; Lin, L.; Lorenzini, R.; Martines, E.; Momo, B.; Sarff, J. S.; Terranova, D.

    2011-12-01

    We report the first direct measurement of the internal magnetic field structure associated with a 3D helical equilibrium generated spontaneously in the core of an axisymmetric toroidal plasma containment device. Magnetohydrodynamic equilibrium bifurcation occurs in a reversed-field pinch when the innermost resonant magnetic perturbation grows to a large amplitude, reaching up to 8% of the mean field strength. Magnetic topology evolution is determined by measuring the Faraday effect, revealing that, as the perturbation grows, toroidal symmetry is broken and a helical equilibrium is established.

  12. Nondiffusive toroidal-momentum-transport in the JFT-2M tokamak plasmas

    Energy Technology Data Exchange (ETDEWEB)

    Ida, Katsumi; Itoh, Kimitaka [National Inst. for Fusion Science, Toki, Gifu (Japan); Miura, Yukitoshi; Itoh, Sanae; Matsuda, Toshiaki

    1998-12-01

    A nondiffusive term in the toroidal-momentum-transport equation is evaluated by the analysis of the transport of toroidal rotation in the transient phase, where the direction of neutral beam injection is changed from parallel to the plasma current to antiparallel. The ratio of nondiffusive viscosity coefficient to diffusive viscosity coefficient is evaluated to be 0.1 to 0.3, which increases as the plasma current is decreased. Nondiffusive momentum transport is found to be in proportion to {nabla}T{sub i}. (author)

  13. Bifurcation to 3D helical magnetic equilibrium in an axisymmetric toroidal device.

    Science.gov (United States)

    Bergerson, W F; Auriemma, F; Chapman, B E; Ding, W X; Zanca, P; Brower, D L; Innocente, P; Lin, L; Lorenzini, R; Martines, E; Momo, B; Sarff, J S; Terranova, D

    2011-12-16

    We report the first direct measurement of the internal magnetic field structure associated with a 3D helical equilibrium generated spontaneously in the core of an axisymmetric toroidal plasma containment device. Magnetohydrodynamic equilibrium bifurcation occurs in a reversed-field pinch when the innermost resonant magnetic perturbation grows to a large amplitude, reaching up to 8% of the mean field strength. Magnetic topology evolution is determined by measuring the Faraday effect, revealing that, as the perturbation grows, toroidal symmetry is broken and a helical equilibrium is established.

  14. Entropy of quantum field in toroidal black hole without brick wall

    Institute of Scientific and Technical Information of China (English)

    Wang Bo-Bo

    2008-01-01

    In this paper the entropy of a toroidal black hole due to a scalar field is investigated by using the DLM scheme.The entropy is renormalized to the standard Bekenstein-Hawking formula with a one-loop correction arising from the higher curvature terms of the gravitational action. For the scalar field,the renormalized Newton constant and two renormalized coupling constants in the toroidal black hole are the same as those in the Reissner-Nordstrom black hole except for other one.

  15. Design and Comparison of a 1 MW / 5s HTS SMES with Toroidal and Solenoidal Geometry

    CERN Document Server

    Morandi, Antonio; Gholizad, Babak; Grilli, Francesco; Sirois, Frédéric; Zermeño, Víctor M R

    2015-01-01

    The design of a HTS SMES coil with solenoidal and toroidal geometry is carried out based on a commercially available 2G HTS conductor. A SMES system of practical interest (1 MW / 5 s) is considered. The comparison between ideal toroidal and solenoidal geometry is first discussed and the criteria used for choosing the geometrical parameters of the coils' bore are explained. The design of the real coil is then carried out and the final amount of conductor needed is compared. A preliminary comparison of the two coils in terms of AC loss during one charge discharge cycle is also discussed.

  16. On the possibility of controlling the hydrophilic/hydrophobic characteristics of toroid Mo138 nanocluster polyoxometalates

    Science.gov (United States)

    Grzhegorzhevskii, K. V.; Adamova, L. V.; Eremina, E. V.; Ostroushko, A. A.

    2017-03-01

    The possibility of changing the hydrophilic (polar) surfaces of toroid nanocluster polyoxomolibdates to hydrophobic (nonpolar) surfaces via the modification of Mo138 nanoclusters by surfactant molecules (dodecylpyridinium chloride) as a result of the interaction between these compounds in solutions is demonstrated. Benzene and methanol are used as molecular probes (indicators of the condition of nanocluster surfaces). Comparative characteristics of the equilibrium sorption of benzene and methanol vapors on the initial and modified surfaces of the solid polyoxometalate, and data on the sorption of organic molecules on the surfaces of Rhodamine B-modified nanoclusters of the toroid (Mo138) and keplerate (Mo132) types are obtained.

  17. Over-expression of ATF3 Inhibits the Proliferation of Esophageal Squamous Carcinoma Cells%激活转录因子3的过表达对食管癌细胞生长的抑制作用

    Institute of Scientific and Technical Information of China (English)

    谢仰民; 谢剑君; 周飞; 侯健; 曹君君; 许丽艳; 李恩民

    2009-01-01

    背景与目的:激活转录因子3(activating transcription factor 3,ATF3)在食管癌中表达异常下调,但其功能仍不清楚.本研究拟探讨ATF3在食管癌细胞过表达对癌细胞生长及裸鼠成瘤的影响. 材料与方法:利用分子克隆技术将ATF3基因完整编码区克隆至真核细胞表达载体pcDNA3中,获得重组表达质粒;将该表达质粒转染食管癌EC109细胞并用G418筛选稳定表达的细胞克隆;用Western blot检测ATF3的过表达效果;对ATF3过表达的细胞与相应对照细胞进行细胞克隆形成实验和裸鼠体内成瘤实验,以分析ATF3过表达对食管癌细胞生长的影响. 结果:ATF3的过表达在体外可以降低食管癌细胞的克隆形成能力;在体内可以抑制食管癌细胞在雌鼠中的成瘤能力,但对雄鼠中的成瘤能力没有明显影响.结论:ATF3的过表达可以抑制食管癌细胞的生长,ATF3可能在食管癌的发生发展中发挥重要作用.%BACKGROUND AND AIM: ATF3 was down-regulated in esophageal squamous cell carcinoma (ESCC), but the roles of ATF3 in ESCC cells still remained unclear. The purpose of this study was to explore the effect of ATF3 on the proliferation of ESCC cells. MATERIALS AND METHODS: The recombinant expressing plasmid was constructed by inserting the full coding sequence of ATF3 gene into the eukaryotic expressing vector pcDNA3. Then, the expressing plasmid was stably transfected into EC 109 cells, an ESCC cell line, and the over-expressing ATF3 cell clones were obtained. Colony formation assay and tumor formation assay in nude mice were used to explore the effect of ATF3 over-expression on the proliferation of ESCC cells. RESULTS: With the over-expression of ATF3, the colony formation ability of EC109 cells was decreased and the tumor formation of EC109 cells in female mice was inhibited. CONCLUSION: Over-expression of ATF3 could inhibit the proliferation of ESCC cells and ATF3 may play important roles in the progression of ESCC.

  18. Evaluation of a relativistic electron ring system as a plasma target for buildup of compact-toroid configurations

    Energy Technology Data Exchange (ETDEWEB)

    Condit, W.C.

    1980-06-26

    A review of the idea of using plasma-loaded electron rings as buildup targets for future compact-toroid machines is presented. Present experiments at Cornell University and Nagoya University are analyzed, and the need for auxiliary heating to reach interesting temperatures is described. Consideration of the effect of two-stream instability, toroidal field, and plasma containment are discussed.

  19. Toroidal-Core Microinductors Biased by Permanent Magnets

    Science.gov (United States)

    Lieneweg, Udo; Blaes, Brent

    2003-01-01

    The designs of microscopic toroidal-core inductors in integrated circuits of DC-to-DC voltage converters would be modified, according to a proposal, by filling the gaps in the cores with permanent magnets that would apply bias fluxes (see figure). The magnitudes and polarities of the bias fluxes would be tailored to counteract the DC fluxes generated by the DC components of the currents in the inductor windings, such that it would be possible to either reduce the sizes of the cores or increase the AC components of the currents in the cores without incurring adverse effects. Reducing the sizes of the cores could save significant amounts of space on integrated circuits because relative to other integrated-circuit components, microinductors occupy large areas - of the order of a square millimeter each. An important consideration in the design of such an inductor is preventing magnetic saturation of the core at current levels up to the maximum anticipated operating current. The requirement to prevent saturation, as well as other requirements and constraints upon the design of the core are expressed by several equations based on the traditional magnetic-circuit approximation. The equations involve the core and gap dimensions and the magnetic-property parameters of the core and magnet materials. The equations show that, other things remaining equal, as the maximum current is increased, one must increase the size of the core to prevent the flux density from rising to the saturation level. By using a permanent bias flux to oppose the flux generated by the DC component of the current, one would reduce the net DC component of flux in the core, making it possible to reduce the core size needed to prevent the total flux density (sum of DC and AC components) from rising to the saturation level. Alternatively, one could take advantage of the reduction of the net DC component of flux by increasing the allowable AC component of flux and the corresponding AC component of current

  20. Urotensin II inhibits doxorubicin-induced human umbilical vein endothelial cell death by modulating ATF expression and via the ERK and Akt pathway.

    Directory of Open Access Journals (Sweden)

    Yen-Ling Chen

    Full Text Available BACKGROUND AND PURPOSE: Regulation of the homeostasis of vascular endothelium is critical for the processes of vascular remodeling and angiogenesis under physiological and pathological conditions. Urotensin II (U-II, a potent vasoactive peptide, participates in vascular and myocardial remodeling after injury. We investigated the protective effect of U-II on doxorubicin (DOX-induced apoptosis in cultured human umbilical vein endothelial cells (HUVECs and the potential mechanisms involved in this process. EXPERIMENTAL APPROACH: Cultured HUVECs were treated with vehicle, DOX (1 µM, U-II, or U-II plus DOX. Apoptosis was evaluated by DNA strand break level with TdT-mediated dUTP nick-end labeling (TUNEL staining. Western blot analysis was employed to determine the related protein expression and flow cytometry assay was used to determine the TUNEL positive cells. KEY RESULTS: U-II reduced the quantity of cleaved caspase-3 and cytosol cytochrome c and increased Bcl-2 expression, which results in protecting HUVECs from DOX-induced apoptosis. U-II induced Activating transcription factor 3 (ATF3 at both mRNA and protein levels in U-II-treated cells. Knockdown of ATF3 with ATF3 siRNA significantly reduced ATF3 protein levels and U-II protective effect under DOX-treated condition. U-II downregulated p53 expression in DOX-induced HUVECs apoptosis, and it rapidly activated extracellular signal-regulated protein kinase (ERK and Akt. The DOX induced change of p53 was not affected by U-II antagonist (urantide under ATF-3 knockdown. The inhibitory effect of U-II on DOX-increased apoptosis was attenuated by inhibitors of ERK (U0126 and PI3K/Akt (LY294002. CONCLUSION AND IMPLICATIONS: Our observations provide evidence that U-II protects HUVECs from DOX-induced apoptosis. ERK-Akt phosphorylation, ATF3 activation, and p53 downregulation may play a signal-transduction role in this process.

  1. Advanced fusion concepts: project summaries

    Energy Technology Data Exchange (ETDEWEB)

    None

    1980-12-01

    This report contains descriptions of the activities of all the projects supported by the Advanced Fusion Concepts Branch of the Office of Fusion Energy, US Department of Energy. These descriptions are project summaries of each of the individual projects, and contain the following: title, principle investigators, funding levels, purpose, approach, progress, plans, milestones, graduate students, graduates, other professional staff, and recent publications. Information is given for each of the following programs: (1) reverse-field pinch, (2) compact toroid, (3) alternate fuel/multipoles, (4) stellarator/torsatron, (5) linear magnetic fusion, (6) liners, and (7) Tormac. (MOW)

  2. Neoclassical toroidal plasma viscosity with effects of finite banana width for finite aspect ratio tokamaks

    Science.gov (United States)

    Shaing, K. C.; Sabbagh, S. A.

    2016-07-01

    Theory for neoclassical toroidal plasma viscosity has been developed to model transport phenomena, especially, toroidal plasma rotation for tokamaks with broken symmetry. Theoretical predictions are in agreement with the results of the numerical codes in the large aspect ratio limit. The theory has since been extended to include effects of finite aspect ratio and finite plasma β. Here, β is the ratio of the plasma thermal pressure to the magnetic field pressure. However, there are cases where the radial wavelength of the self-consistent perturbed magnetic field strength B on the perturbed magnetic surface is comparable to the width of the trapped particles, i.e., bananas. To accommodate those cases, the theory for neoclassical toroidal plasma viscosity is further extended here to include the effects of the finite banana width. The extended theory is developed using the orbit averaged drift kinetic equation in the low collisionality regimes. The results of the theory can now be used to model plasma transport, including toroidal plasma rotation, in real finite aspect ratio, and finite plasma β tokamaks with the radial wavelength of the perturbed symmetry breaking magnetic field strength comparable to or longer than the banana width.

  3. Optimizing dc-resistance of a foil wounded toroidal inductor combining matlab and comsol

    DEFF Research Database (Denmark)

    Schneider, Henrik; Andersen, Thomas; Knott, Arnold

    2013-01-01

    An optimization routine is presented to optimize the shape of a foil winding of a toroid inductor in terms of the DC resistance. MATLAB was used to define the geometry of the foil winding and COMSOL was used to import the geometry and create a 3D finite element model. The initial parameters...

  4. The effect of toroidal plasma rotation on low-frequency reversed shear Alfven eigenmodes in tokamaks

    NARCIS (Netherlands)

    Haverkort, J. W.

    2012-01-01

    The influence of toroidal plasma rotation on the existence of reversed shear Alfven eigenmodes (RSAEs) near their minimum frequency is investigated analytically. An existence condition is derived showing that a radially decreasing kinetic energy density is unfavourable for the existence of RSAEs. Th

  5. Investigation of a Hybrid Winding Concept for Toroidal Inductors using 3D Finite Element Modeling

    DEFF Research Database (Denmark)

    Schneider, Henrik; Andersen, Thomas; Mønster, Jakob Døllner;

    2013-01-01

    This paper investigates a hybrid winding concept for a toroidal inductor by simulating the winding resistance as a function of frequency. The problem of predicting the resistance of a non-uniform and complex winding shape is solved using 3D Finite Element Modeling. A prototype is built and tested...

  6. Performance assessment and optimization of the ITER toroidal field coil joints

    NARCIS (Netherlands)

    Rolando, G.; Foussat, A.; Knaster, J.; Illiin, Y.; Nijhuis, A.

    2013-01-01

    The ITER toroidal field (TF) system features eighteen coils that will provide the magnetic field necessary to confine the plasma. Each winding pack is composed of seven double pancakes (DP) connected through praying hands joints. Shaking hands joints are used to interface the terminals of the conduc

  7. Internal Field of Homogeneously Magnetized Toroid Sensor for Proton Free Precession Magnetometer

    DEFF Research Database (Denmark)

    Primdahl, Fritz; Merayo, José M.G.; Brauer, Peter

    2005-01-01

    The shift of the NMR spectral line frequency in a proton free precession absolute scalar magnetometer using the omni-directional toroid container for a proton-rich liquid depends on the magnetic susceptibility of the liquid and on the direction of the external field relative to the axis of the to......The shift of the NMR spectral line frequency in a proton free precession absolute scalar magnetometer using the omni-directional toroid container for a proton-rich liquid depends on the magnetic susceptibility of the liquid and on the direction of the external field relative to the axis...... of the toroid. The theoretical shift is estimated for water by computing the additional magnetic field from the magnetization of the liquid and comparing it to the theoretical field in a spherical container. Along the axis the estimated average shift is -0.08 nT and perpendicular to the axis the shift is +0.......08 nT relative to that of a spherical sensor. The field inhomogeneity introduced by the toroid shape amounts to 0.32 nT over the volume of the sensor and is not expected to significantly affect the signal decay time, when considering the typical water line width of about 2.5 InT....

  8. Generation of rotational flows in toroidally confined visco-resistive magnetohydrodynamics

    Science.gov (United States)

    Morales, Jorge; Bos, Wouter; Schneider, Kai; Montgomery, David

    2015-11-01

    We investigate by numerical simulation the generation of rotational flows in a toroid confining a conducting magnetofluid. A current is driven by the application of externally supported electric and magnetic fields. We show how the properties and intensity of the rotations are regulated by dimensionless numbers (Lundquist and viscous Lundquist) that contain the resistivity and viscosity of the magnetofluid. At the magnetohydrodynamic level (uniform mass density and incompressible magnetofluids), rotational flows appear in toroidal, driven MHD. The evolution of these flows with the transport coefficients, geometry, and safety factor are described. Two different toroidal geometries are considered, one with an up-down symmetric and the other with an asymmetric cross section. We show that there exists a fundamental difference between both studied cases: the volume-averaged angular momentum is zero for the symmetric case, while for the asymmetric cross section a finite volume-averaged angular momentum appears. We observe a breaking in the up-down symmetry of the flow and a toroidal preferred direction emerges.

  9. A toroidal trap for the cold $^{87}Rb$ atoms using a rf-dressed quadrupole trap

    CERN Document Server

    Chakraborty, A; Ram, S P; Tiwari, S K; Rawat, H S

    2015-01-01

    We demonstrate the trapping of cold $^{87}Rb$ atoms in a toroidal geometry using a rf-dressed quadrupole magnetic trap formed by superposing a strong radio frequency (rf) field on a quadrupole trap. This rf-dressed quadrupole trap has minimum of the potential away from the quadrupole trap centre on a circular path which facilitates the trapping in the toroidal geometry. In the experiments, the laser cooled atoms were first trapped in the quadrupole trap, then cooled evaporatively using a weak rf-field, and finally trapped in the rf-dressed quadrupole trap. The radius of the toroid could be varied by varying the frequency of the dressing rf-field. It has also been demonstrated that a single rf source and an antenna can be used for the rf-evaporative cooling as well as for rf-dressing of atoms. The atoms trapped in the toroidal trap may have applications in realization of an atom gyroscope as well as in studying the quantum gases in low dimensions.

  10. Toroidal rotation braking with n = 1 magnetic perturbation field on JET

    DEFF Research Database (Denmark)

    Sun, Y; Liang, Y; Koslowski, H R;

    2010-01-01

    A strong toroidal rotation braking has been observed in plasmas with application of an n = 1 magnetic perturbation field on the JET tokamak. Calculation results from the momentum transport analysis show that the torque induced by the n = 1 perturbation field has a global profile. The maximal valu...

  11. A Study on Main Breaker for Quench Protection of HT-7U Toroidal Superconducting Tokamak

    Institute of Scientific and Technical Information of China (English)

    许留伟; 刘小宁

    2002-01-01

    This paper proposes a quench protection project of HT-7U toroidal superconducting tokamak through a forced commutation analysis of DC circuit breaker (DCCB) paralleling fuse.Based on the requirement of quench protection, main parameters are selected. Experimental results demonstrate the validity of this proposed project.

  12. A study on Main Breaker for Quench Protection of HT—7U Toroidal Superconducting Tokammak

    Institute of Scientific and Technical Information of China (English)

    许留伟; 刘小宁

    2002-01-01

    This paper proposes a quench protection project of HT-7U toroidal superconducting tokamak through a forced commutation analysis of DC circuit breaker(DCCB) paralleling fuse.Based on the requirement of quench protection.Amin parameters are selected.Experimental results demonstrate the validity of this proposed project.

  13. Manifestation of the cyclo-toroid nuclear moment in anomalous conversion and Lamb shift

    CERN Document Server

    Tkalya, E V

    2005-01-01

    We offer the hypothesis that atomic nuclei, nucleons, and atoms possess a new type of electromagnetic moment, that we call a ``cyclo-toroid moment''. In nuclei, this moment arises when the toroid dipole (anapole) moments are arrayed in the form of a ring, or, equivalently, when the magnetic moments of the nucleons are arranged in the form of rings which, in turn, constitute the surface of a torus. We establish theoretically that the cyclo-toroid moment plays a role in the processes of the atomic shell--nucleus interaction. The existence of this moment would explain known anomalies in the internal conversion coefficients for $M1$ transitions in nuclei. We show also that the static cyclo-toroid nuclear moment interacts locally inside the nucleus with the vortex part of the atomic electron currents and this leads to an energy shift in atomic $s_{1/2}$ states. For the hydrogen atom the value of this shift may be comparable in order of magnitude to the present accuracy of measurements of the Lamb shift for the $1s...

  14. Conceptual Design of a New Large Superconducting Toroid for IAXO, the New International AXion Observatory

    CERN Document Server

    Shilon, I; Silva, H; Kate, H H J ten

    2013-01-01

    The International AXion Observatory (IAXO) will incorporate a new generation detector for axions, a hypothetical particle, which was postulated to solve one of the puzzles arising in the standard model of particle physics, namely the strong CP problem. The new IAXO experiment is aiming at achieving a sensitivity to the coupling between axions and photons of one order of magnitude beyond the limits of the current state-of-the-art detector, represented by the CERN Axion Solar Telescope (CAST). The IAXO detector relies on a high-magnetic field distributed over a very large volume to convert solar axions into x-ray photons. Utilizing the designs of the ATLAS barrel and end-cap toroids, a large superconducting toroidal magnet is currently being designed at CERN to provide the required magnetic field. The new toroid will be built up from eight, one meter wide and 20 m long, racetrack coils. The toroid is sized about 4 m in diameter and 22 m in length. It is designed to realize a peak magnetic field of 5.4 T with a ...

  15. The Dynamics of an Isolated Plasma Filament at the Edge of a Toroidal Device, Rev. 1

    Energy Technology Data Exchange (ETDEWEB)

    Ryutov, D D

    2006-09-28

    The dynamics of an isolated plasma filament (an isolated blob) in the far scrape-off layer (SOL) of a toroidal device is described, with a proper averaging of the geometrical parameters as well as plasma parameters along the filament. The analysis is limited to the magnetohydrodynamic description. The effects of the anchored ends and finite plasma resistivity are also discussed.

  16. Toroidal and poloidal soft x-ray imaging system on the DIII-D tokamak

    Science.gov (United States)

    Snider, R. T.; Evanko, R.; Haskovec, J.

    1988-08-01

    A toroidal soft x-ray imaging system is being added to the currently installed poloidal soft x-ray system on the DIII-D tokamak. The poloidal array is used to determine the poloidal mode structure and location of internal helical MHD perturbations in the plasma. The new array will add toroidal mode identification capability. The four detector arrays are toroidally spaced in a manner that allows identification of toroidal mode numbers up to 24. Beryllium vacuum windows separate the detectors from the tokamak vacuum and also serve as low-energy filters. The separate detector vacuum chambers can be filled with a gas that changes the low-energy cutoff of the system. By proper selection of the gas and pressure the low-energy cutoff can be chosen over the entire range of the detector sensitivity (500-1200 eV). This capability can be used to produce crude x-ray spectra for the entire imaging system or for gain control.

  17. Toroidal and poloidal soft X-ray imaging system on the D3-D tokamak

    Science.gov (United States)

    Snider, R.; Evanko, R.; Haskovec, J.

    1988-02-01

    A toroidal soft X-ray imaging system is being added to the currently installed poloidal soft X-ray system on the D3-D tokamak. The poloidal array is used to determine the poloidal mode structure and location of internal helical MHD perturbations in the plasma. The new array will add toroidal mode identification capability. The four detector arrays are toroidally spaced in a manner which allows identification of toroidal mode numbers of up to 24. Beryllium vacuum windows separate the detectors from the tokamak vacuum and also serve as low energy filters. The separate detector vacuum chambers can be filled with a gas which changes the low energy cutoff of the system. By proper selection of the gas and pressure the low energy cutoff can be chosen over the entire range of the detector sensitivity (500 eV to 1200 eV). This capability can be used to produce crude X-ray spectra for the entire imaging system or for gain control.

  18. On the fundamental mode of the optical resonator with toroidal mirrors

    Energy Technology Data Exchange (ETDEWEB)

    Serednyakov, S.S.; Vinokurov, N.A. [Budker Institute of Nuclear Physics, Novosibirsk (Russian Federation)

    1995-12-31

    The fundamental mode of the optical resonator with the toroidal mirrors is investigated. The losses in such resonator with the on-axis holes are low in compare with the case of spherical mirrors. The use of this type of optical resonator is briefly discussed.

  19. 耐力训练对心肌PERK/eIF2α/ATF4信号通路激活的影响%Effects of Endurance Exercise Training on PERK/eIF2α/ATF4 Signaling Pathway in Cardiac Muscle

    Institute of Scientific and Technical Information of China (English)

    王蕴红; 王智强; 刘晓然; 陈怡月; 李丁丁; 余海燕; 姚政立

    2016-01-01

    探讨内质网应激机制在耐力训练对心肌功能影响过程中的作用.方法:通过建立不同运动方式、运动训练状态和不同恢复阶段的动物模型,测定心肌中与内质网应激相关的信号通路PERK/eIF2α/ATF4激活水平的变化.结果:无论是急性运动,还是4或10周的递增负荷耐力训练,都没有显著激活PERK/eIF2α/ATF4信号通路,但是以延长运动时间为特征的耐力训练能够激活PERK/eIF2α/ATF4信号通路.结论:以递增运动时间为特征的耐力训练能够激活PERK/eIF2α/ ATF4信号通路,该通路的激活对运动心肌的结构和功能变化可能产生影响.

  20. Negative Regulation of IRF7 Activation by ATF4 Suggests a Cross Regulation Between the Interferon Responses and the Cellular Integrated Stress Responses

    OpenAIRE

    Liang, Qiming; Deng, Hongying; Sun, Chiao-Wang; Tim M. Townes; Zhu, Fanxiu

    2010-01-01

    Cells react to viral infection by exhibiting interferon (IFN)-based innate immune responses and integrated stress responses, but little is known about the interrelationships between the two. We here report a linkage between these two host protective cellular mechanisms. We found that IRF7, the master regulator of type I IFN gene expression, interacts with ATF4, a key component of the integrated stress responses whose translation is induced by viral infection and various stresses. We have demo...

  1. Role of areca nut induced JNK/ATF2/Jun axis in the activation of TGF-β pathway in precancerous Oral Submucous Fibrosis

    Science.gov (United States)

    Pant, Ila; Rao, S. Girish; Kondaiah, Paturu

    2016-01-01

    Oral submucous fibrosis (OSF) is potentially premalignant with progressive and irreversible extracellular matrix deposition accompanied by epithelial atrophy and like other fibrotic disorders, is primarily a TGF-β driven disease. OSF is caused by prolonged chewing of areca nut. Our previous studies reported a pivotal role for TGF-β activation and its effects contributing to OSF. However, the mechanism for activation of TGF-β signaling in OSF is still unknown. In this study we demonstrate activation of TGF-β signaling with sub-cytotoxic dose of areca nut in epithelial cells and discovered a key role for pJNK in this process. In good correlation; pJNK was detected in OSF tissues but not in normal tissues. Moreover, activation of JNK was found to be dependent on muscarinic acid receptor induced Ca2+/CAMKII as well as ROS. JNK dependent phosphorylation of ATF2/c-Jun transcription factors resulted in TGF-β transcription and its signaling. pATF2/p-c-Jun were enriched on TGF-β promoter and co-localized in nuclei of epithelial cells upon areca nut treatment. In corroboration, OSF tissue sections also had nuclear pATF2 and p-c-Jun. Our results provide comprehensive mechanistic details of TGF-β signaling induced by etiological agent areca nut in the manifestation of fibrosis which can lead to new therapeutic modalities for OSF. PMID:27708346

  2. Global stability of plasmas with helical boundary deformation and net toroidal current against n=1,2 external modes

    Energy Technology Data Exchange (ETDEWEB)

    Ardela, A.; Cooper, W.A. [Ecole Polytechnique Federale, Lausanne (Switzerland). Centre de Recherche en Physique des Plasma (CRPP)

    1996-09-01

    In this paper we resume a numerical study of the global stability of plasma with helical boundary deformation and non null net toroidal current. The aim was to see whether external modes with n=1,2 (n toroidal mode number) can be stabilized at values of {beta} inaccessible to the tokamak. L=2,3 configurations with several aspect ratios and different numbers of equilibrium field periods are considered. A large variety of toroidal current densities and different pressure profiles are taken into account. Mercier stability is also investigated. (author) 4 figs., 6 refs.

  3. Linear Collider Test Facility: Twiss Parameter Analysis at the IP/Post-IP Location of the ATF2 Beam Line

    Energy Technology Data Exchange (ETDEWEB)

    Bolzon, Benoit; /Annecy, LAPP; Jeremie, Andrea; /Annecy, LAPP; Bai, Sha; /Beijing, Inst. High Energy Phys.; Bambade, Philip; /KEK, Tsukuba; White, Glen; /SLAC

    2012-07-02

    At the first stage of the ATF2 beam tuning, vertical beam size is usually bigger than 3 {micro}m at the IP. Beam waist measurements using wire scanners and a laser wire are usually performed to check the initial matching of the beam through to the IP. These measurements are described in this paper for the optics currently used ({beta}{sub x} = 4cm and {beta}{sub y} = 1mm). Software implemented in the control room to automate these measurements with integrated analysis is also described. Measurements showed that {beta} functions and emittances were within errors of measurements when no rematching and coupling corrections were done. However, it was observed that the waist in the horizontal (X) and vertical (Y) plane was abnormally shifted and simulations were performed to try to understand these shifts. They also showed that multiknobs are needed in the current optics to correct simultaneously {alpha}{sub x}, {alpha}{sub y} and the horizontal dispersion (D{sub x}). Such multiknobs were found and their linearity and orthogonality were successfully checked using MAD optics code. The software for these multiknobs was implemented in the control room and waist scan measurements using the {alpha}{sub y} knob were successfully performed.

  4. Overview of Compact Toroidal Hybrid research program progress and plans

    Science.gov (United States)

    Maurer, David; Ennis, David; Hanson, James; Hartwell, Gregory; Herfindal, Jeffrey; Knowlton, Stephen; Ma, Xingxing; Pandya, Mihir; Roberds, Nicholas; Ross, Kevin; Traverso, Peter

    2016-10-01

    disruptive behavior on the level of applied 3D magnetic shaping; (2) test and advance the V3FIT reconstruction code and NIMROD modeling of CTH; and (3) study the implementation of an island divertor. Progress towards these goals and other developments are summarized. The disruptive density limit exceeds the Greenwald limit as the vacuum transform is increased, but a threshold for avoidance is not observed. Low- q disruptions, with 1.1 behavior has been reproducibly modified with external transform and NIMROD is used to model these observations and reproduces experimental trends. An island divertor design has begun with connection length studies to model energy deposition on divertor plates located in an edge 1/3 island as well as the study of a non-resonant divertor configuration. This work is supported by U.S. Department of Energy Grant No. DE-FG02-00ER54610.

  5. 结直肠癌组织ATF3及其靶基因Cyclin D1与Maspin表达的临床意义分析%Expression of ATF3 and target genes Cyclin D1 and Maspin in colorectal cancer tissues

    Institute of Scientific and Technical Information of China (English)

    臧盛兵; 郁万媛; 陈虹; 施磊健; 李婷婷; 陈安敏; 陈虹; 黄爱民

    2012-01-01

    OBJECTIVE: To study the expressions of ATF3 and its target genes Cyclin Dland Maspin in colorectal neoplasms by tissue chips, and investigate the meaning of ATF3 expression in colorectal neoplasms. METHODS: Tissue chips were constructed, which contained colorectal cancer and non-neoplastic colorectal mucosa tissue. The expressions of ATF3,Cyclin D1 and Maspin were determined by immunohistochemistry assay. RRSULTS: The expressions of ATF3 (70. 3%),Cyclin D1 (51.4%) and Maspin (59. 5%) in colorectal neoplasms were higher than that in normal colorectal mucosa tissue (21. 6% ,2. 7% and 13. 5% respectively) .which showed significantly difference (all P values were 0. 000). ATF3 expression had not association with age,gender,tumor location,tumor size or histological type,but with invasive extent and lymphatic node metastasis, the expressions of ATF3 in colorectal neoplasms invading the serous membrane (83. 3%) and lymphatic node metastasis (92. 3%) were higher than that in those invading muscularis propria (38. 9%) and without lymphatic node metastasis (45. 7%) ,χ2 values were 13. 290 and 17. 110,and all P values were 0. 000. Cyclin Dl expression was not associated with age,gender,tumor location or tumor size,but with histological type,invasive extent and lymphatic node metastasis. The expression of Cyclin D1 in colorectal cancer with low differentiation (71. 4%), serous membrane invasion (61. 1%) and lymphatic node metastasis (69. 2%) were higher than that in those with high differentiation (39. 1%), muscularis propria invasion (28. 8%) and without lymphatic node metastasis (31. 4%) ,χ2 values were7. 268,6. 019 and 10. 550,and P values were 0. 007,0. 014 and 0. 001 respectively. Maspin expressions were not significantly associated with age, gender, tumor location, tumor size, histological type, invasive extent or lymphatic node metastasis (all P>0. 05). ATF3,Cyclin D1 and Maspin wew all high expressions in colorectal neoplasms, ATF3 expression was positively

  6. Enhanced activation of PERK-ATF4 pathway by Brefeldin A and cisplatin in human lung cancer GLC-82 ;cells%布雷菲德菌素A联合顺铂增强肺癌GLC-82细胞PERK-ATF4通路的激活水平

    Institute of Scientific and Technical Information of China (English)

    吴明松; 郑翔; 耿娜娜; 张志敏; 赵彦禹; 王哲; 李学英

    2016-01-01

    目的:研究PERK-ATF4通路的激活水平,以探讨布雷菲德菌素A(BFA)与顺铂(CDDP)的协同抗肺癌的分子机制。方法:以BFA、CDDP单独或联合处理人肺癌GLC-82细胞24、48 h,然后用定量PCR和Western Blot检测PERK、ATF4、p-PERK的表达水平。结果:药物处理24和48 h 后,GLC-82细胞PERK的mRNA和蛋白表达水平在CDDP组最低,在BFA组升高(P<0.05),在BFA+CDDP组进一步升高(P <0.01),其磷酸化水平均显著降低(P <0.01);ATF4表达在CDDP组中差异无显著性,在BFA组中升高,在BFA+CDDP组进一步升高(P <0.05或P <0.01),也高于BFA组和CDDP组(P <0.05或P <0.01)。结论:BFA联合CDDP上调PERK、ATF4水平,该通路可能是BFA与顺铂协同抗肺癌的分子机制之一。%Objective To investigate the molecular mechanisms of synergistic effects of BFA and CDDP on human lung cancer GLC-82 cells, and to test the levels of PERK-ATF4 pathway. Methods GLC-82 cells were incubated with 50 ng/mL of BFA or/and 2 μg/mL of CDDP for 24 or 48 hours. The levels of PERK, p-PERK and ATF4 in GLC-82 were analyzed by real-time PCRand/or Western Blot. Results The levels of PERK were lowest in CDDP group, but higher in BFA group (P < 0.05), the highest in group of BFA+CDDP (P < 0.05 or P < 0.01). The p-PERK level decreased in group of BFA+CDDP (P < 0.05 or P < 0.01). There was no significant change of ATF4 expression in CDDP group, but ATF4 expression increased slightly in BFA group, and increased further in group of BFA+CDDP (P < 0.05 or P < 0.01)which was also higher than that in BFA group or CDDP group (P < 0.05 or P < 0.01). Conclusions The upregulated levels of PERK and ATF4 by the combination of BFA and CDDP may be one of the mechanisms of synergistic anti-cancer effect of BFA and CDDP on GLC-82 cells.

  7. Toroidal current profile control during low confinement mode plasma discharges in DIII-D via first-principles-driven model-based robust control synthesis

    Science.gov (United States)

    Barton, Justin E.; Boyer, Mark D.; Shi, Wenyu; Schuster, Eugenio; Luce, Tim C.; Ferron, John R.; Walker, Michael L.; Humphreys, David A.; Penaflor, Ben G.; Johnson, Robert D.

    2012-12-01

    In order for ITER to be capable of operating in advanced tokamak operating regimes, characterized by a high fusion gain, good plasma confinement, magnetohydrodynamic stability and a non-inductively driven plasma current, for extended periods of time, several challenging plasma control problems still need to be solved. Setting up a suitable toroidal current density profile in the tokamak is key for one possible advanced operating scenario characterized by non-inductive sustainment of the plasma current. At the DIII-D tokamak, the goal is to create the desired current profile during the ramp-up and early flat-top phases of the plasma discharge and then actively maintain this target profile for the remainder of the discharge. The evolution in time of the toroidal current profile in tokamaks is related to the evolution of the poloidal magnetic flux profile, which is modelled in normalized cylindrical coordinates using a first-principles, nonlinear, dynamic partial differential equation (PDE) referred to as the magnetic diffusion equation. The magnetic diffusion equation is combined with empirical correlations developed from physical observations and experimental data from DIII-D for the electron temperature, the plasma resistivity and the non-inductive current drive to develop a simplified, control-oriented, nonlinear, dynamic PDE model of the poloidal flux profile evolution valid for low confinement mode discharges. In this work, we synthesize a robust feedback controller to reject disturbances and track a desired reference trajectory of the poloidal magnetic flux gradient profile by employing the control-oriented model of the system. A singular value decomposition of the static gain matrix of the plant model is utilized to identify the most relevant control channels and is combined with the dynamic response of system around a given operating trajectory to design the feedback controller. A general framework for real-time feedforward + feedback control of magnetic and

  8. Studies on orange oil methyl ester in diesel engine with hemispherical and toroidal combustion chamber

    Directory of Open Access Journals (Sweden)

    Karthickeyan Viswanathan

    2016-01-01

    Full Text Available An investigation has been made to compare the emission characteristics of 20% orange oil methyl ester and 80% diesel in volumetric basis with Neat diesel in hemispherical combustion chamber and toroidal combustion chamber. Non-edible orange oil is selected and utilized to prepare alternative fuel to be utilized in Diesel engine. The traditional method of transestrification is employed for preparation orange oil methyl ester. The chemical properties of prepared methyl ester were determined using fouriertransform infrared spectroscopy method. Further its fuel properties were found based on American Society for Testing and Materials standards and compared with Neat diesel fuel properties. A compression ignition engine with electrical dynamometer test rig with gas analyzer has been used. It is observed that 1% of NOx and 4% of HC emission reduced in toroidal combustion chamber engine. However, smoke emission is found to be lower in hemispherical combustion chamber engine.

  9. Experimental Phenomena of Improved Ohmic Confinement Induced by Modulated Toroidal Current on the HT-7 Tokamak

    Institute of Scientific and Technical Information of China (English)

    毛剑珊; 罗家融; P.Phillips; 赵君煜; 揭银先; 吴振伟; 胡立群; 李建刚

    2002-01-01

    The phenomena of improved ohmic confinement have been observed during the modulation of the toroidal curranton the Hefei superconducting Tokamak-7 (HT-7). In the experiment, the programming ohmic heating field wasmodulated. A toroidal frequency-modulated current induced by modulated loop voltage was added on the plasmaequilibrium current. The ratio of ac amplitude of the plasma current to the main plasma current is about 12-30%.These improved plasma confinement phenomena include the facts that the average electron density and the centralelectron temperature both increase, the Dα radiation from the edge is reduced, the magnetohydrodynamics isobviously suppressed by oscillating plasma current, eand the global energy confinement time increases by 27-45%o.It is found that the faster the modulation is, the more effective the improved ohmic confinement phase.

  10. Temperature distribution in magnetized neutron star crusts. II. The effect of a strong toroidal component

    CERN Document Server

    Geppert, U; Page, D; Page, Dany

    2005-01-01

    We continue the study of the effects of a strong magnetic field on the temperature distribution in the crust of a magnetized neutron star (NS) and its impact on the observable surface temperature. Extending the approach initiated in Geppert et al.(2004), we consider more complex and, hence, more realistic, magnetic field structures but still restrict ourselves to axisymmetric configurations. We put special emphasis on the heat blanketing effect of a toroidal field component. We show that asymmetric temperature distributions can occur and a crustal field consisting of dipolar poloidal and toroidal components will cause one polar spot to be larger than the opposing one. These two warm regions can be separated by an extended cold equatorial belt. We present an internal magnetic field structure which can explain both the X-ray and optical spectra of the isolated NS RXJ 1856-3754. We investigate the effects of the resulting surface temperature profiles on the observable lightcurve which an isolated thermally emitt...

  11. Demonstration of ultra-high-Q small mode volume toroid microcavities on a chip

    CERN Document Server

    Kippenberg, T J; Vahala, K J

    2004-01-01

    Optical microcavities confine light spatially and temporally and find application in a wide range of fundamental and applied studies. In many areas, the microcavity figure of merit is not only determined by photon lifetime (or the equivalent quality-factor, Q), but also by simultaneous achievement of small mode volume V . Here we demonstrate ultra-high Q-factor small mode volume toroid microcavities on-a-chip, which exhibit a Q/V factor of more than $10^{6}(\\lambda/n)^{-3}$. These values are the highest reported to date for any chip-based microcavity. A corresponding Purcell factor in excess of 200 000 and a cavity finesse of $2.8\\times10^{6}$ is achieved, demonstrating that toroid microcavities are promising candidates for studies of the Purcell effect, cavity QED or biochemical sensing

  12. Demonstration of ultra-high-Q small mode volume toroid microcavities on a chip

    Science.gov (United States)

    Kippenberg, T. J.; Spillane, S. M.; Vahala, K. J.

    2004-12-01

    Optical microcavities confine light spatially and temporally and find application in a wide range of fundamental and applied studies. In many areas, the microcavity figure of merit is not only determined by photon lifetime (or the equivalent quality-factor, Q), but also by simultaneous achievement of small mode volume (V). Here we demonstrate ultra-high Q-factor small mode volume toroid microcavities on-a-chip, which exhibit a Q/V factor of more than 106(λ/n)-3. These values are the highest reported to date for any chip-based microcavity. A corresponding Purcell factor in excess of 200 000 and a cavity finesse of >2.8×106 is achieved, demonstrating that toroid microcavities are promising candidates for studies of the Purcell effect, cavity QED or biochemical sensing.

  13. Physical mechanism determining the radial electric field and its radial structure in a toroidal plasma

    Energy Technology Data Exchange (ETDEWEB)

    Ida, Katsumi; Miura, Yukitoshi; Itoh, Sanae [and others

    1994-10-01

    Radial structures of plasma rotation and radial electric field are experimentally studied in tokamak, heliotron/torsatron and stellarator devices. The perpendicular and parallel viscosities are measured. The parallel viscosity, which is dominant in determining the toroidal velocity in heliotron/torsatron and stellarator devices, is found to be neoclassical. On the other hand, the perpendicular viscosity, which is dominant in dictating the toroidal rotation in tokamaks, is anomalous. Even without external momentum input, both a plasma rotation and a radial electric field exist in tokamaks and heliotrons/torsatrons. The observed profiles of the radial electric field do not agree with the theoretical prediction based on neoclassical transport. This is mainly due to the existence of anomalous perpendicular viscosity. The shear of the radial electric field improves particle and heat transport both in bulk and edge plasma regimes of tokamaks. (author) 95 refs.

  14. A Toroidal Magnetised Iron Neutrino Detector (MIND) for a Neutrino Factory

    CERN Document Server

    Bross, A; Bayes, R; Laing, A; Soler, F J P; Villanueva, A Cervera; Ghosh, T; Cadenas, J J Gómez; Hernández, P; Martín-Albo, J; Burguet-Castell, J

    2013-01-01

    A neutrino factory has unparalleled physics reach for the discovery and measurement of CP violation in the neutrino sector. A far detector for a neutrino factory must have good charge identification with excellent background rejection and a large mass. An elegant solution is to construct a magnetized iron neutrino detector (MIND) along the lines of MINOS, where iron plates provide a toroidal magnetic field and scintillator planes provide 3D space points. In this report, the current status of a simulation of a toroidal MIND for a neutrino factory is discussed in light of the recent measurements of large $\\theta_{13}$. The response and performance using the 10 GeV neutrino factory configuration are presented. It is shown that this setup has equivalent $\\delta_{CP}$ reach to a MIND with a dipole field and is sensitive to the discovery of CP violation over 85% of the values of $\\delta_{CP}$.

  15. Modeling and control of plasma rotation for NSTX using neoclassical toroidal viscosity and neutral beam injection

    Energy Technology Data Exchange (ETDEWEB)

    Goumiri, I. R. [Princeton Univ., NJ (United States). Mechanical and Aerospace Dept.; Rowley, C. W. [Princeton Univ., NJ (United States). Mechanical and Aerospace Dept.; Sabbagh, S. A. [Columbia Univ., New York, NY (United States). Dept. of Applied Physics and Applied Mathematics; Gates, D. A. [Princeton Plasma Physics Lab. (PPPL), Princeton, NJ (United States); Gerhardt, S. P. [Princeton Plasma Physics Lab. (PPPL), Princeton, NJ (United States); Boyer, M. D. [Princeton Plasma Physics Lab. (PPPL), Princeton, NJ (United States); Andre, R. [Princeton Plasma Physics Lab. (PPPL), Princeton, NJ (United States); Kolemen, E. [Princeton Plasma Physics Lab. (PPPL), Princeton, NJ (United States); Taira, K. [Florida State Univ, Dept Mech Engn, Tallahassee, FL USA.

    2016-02-19

    A model-based feedback system is presented to control plasma rotation in a magnetically confined toroidal fusion device, to maintain plasma stability for long-pulse operation. This research uses experimental measurements from the National Spherical Torus Experiment (NSTX) and is aimed at controlling plasma rotation using two different types of actuation: momentum from injected neutral beams and neoclassical toroidal viscosity generated by three-dimensional applied magnetic fields. Based on the data-driven model obtained, a feedback controller is designed, and predictive simulations using the TRANSP plasma transport code show that the controller is able to attain desired plasma rotation profiles given practical constraints on the actuators and the available measurements of rotation.

  16. Measurement of toroidal vessel eddy current during plasma disruption on J-TEXT

    Energy Technology Data Exchange (ETDEWEB)

    Liu, L. J.; Yu, K. X.; Zhang, M., E-mail: zhangming@hust.edu.cn; Zhuang, G.; Li, X.; Yuan, T.; Rao, B.; Zhao, Q. [State Key Laboratory of Advanced Electromagnetic Engineering and Technology, School of Electrical and Electronic Engineering, Huazhong University of Science and Technology, Wuhan 430074 (China)

    2016-01-15

    In this paper, we have employed a thin, printed circuit board eddy current array in order to determine the radial distribution of the azimuthal component of the eddy current density at the surface of a steel plate. The eddy current in the steel plate can be calculated by analytical methods under the simplifying assumptions that the steel plate is infinitely large and the exciting current is of uniform distribution. The measurement on the steel plate shows that this method has high spatial resolution. Then, we extended this methodology to a toroidal geometry with the objective of determining the poloidal distribution of the toroidal component of the eddy current density associated with plasma disruption in a fusion reactor called J-TEXT. The preliminary measured result is consistent with the analysis and calculation results on the J-TEXT vacuum vessel.

  17. MHD equilibrium of toroidal fusion plasma with stationary flows; Rownowaga MHD toroidalnej plazmy termojadrowej z przeplywami

    Energy Technology Data Exchange (ETDEWEB)

    Galkowski, A. [Institute of Atomic Energy, Otwock-Swierk (Poland)

    1994-12-31

    Non-linear ideal MHD equilibria in axisymmetric system with flows are examined, both in 1st and 2nd ellipticity regions. Evidence of the bifurcation of solutions is provided and numerical solutions of several problems in a tokamak geometry are given, exhibiting bifurcation phenomena. Relaxation of plasma in the presence of zero-order flows is studied in a realistic toroidal geometry. The field aligned flow allows equilibria with finite pressure gradient but with homogeneous temperature distribution. Numerical calculations have been performed for the 1st and 2nd ellipticity regimes of the extended Grad-Shafranov-Schlueter equation. Numerical technique, alternative to the well-known Grad`s ADM methods has been proposed to deal with slow adiabatic evolution of toroidal plasma with flows. The equilibrium problem with prescribed adiabatic constraints may be solved by simultaneous calculations of flux surface geometry and original profile functions. (author). 178 refs, 37 figs, 5 tabs.

  18. An integral equation-based numerical solver for Taylor states in toroidal geometries

    CERN Document Server

    O'Neil, Michael

    2016-01-01

    We develop an algorithm for the numerical calculation of Taylor states (also known as Beltrami, or force-free fields) in toroidal and toroidal-shell geometries using an analytical framework developed for the solution to the time-harmonic Maxwell equations. The scheme relies on the generalized Debye source representation of Maxwell fields and an integral representation of Beltrami fields which immediately yields a well-conditioned second-kind integral equation. This integral equation has a unique solution whenever the Beltrami parameter $\\lambda$ is not a member of a discrete, countable set of resonances which physically correspond to spontaneous symmetry breaking in the plasma. Several numerical examples relevant to magnetohydrodynamic equilibria calculations are provided. Lastly, our approach easily generalizes to arbitrary geometries, both bounded and unbounded, and of varying genus.

  19. Magnetic field perturbartions in closed-field-line systems with zero toroidal magnetic field

    Energy Technology Data Exchange (ETDEWEB)

    Mauel, M; Ryutov, D; Kesner, J

    2003-12-02

    In some plasma confinement systems (e.g., field-reversed configurations and levitated dipoles) the confinement is provided by a closed-field-line poloidal magnetic field. We consider the influence of the magnetic field perturbations on the structure of the magnetic field in such systems and find that the effect of perturbations is quite different from that in the systems with a substantial toroidal field. In particular, even infinitesimal perturbations can, in principle, lead to large radial excursions of the field lines in FRCs and levitated dipoles. Under such circumstances, particle drifts and particle collisions may give rise to significant neoclassical transport. Introduction of a weak regular toroidal magnetic field reduces radial excursions of the field lines and neoclassical transport.

  20. Tracking formulas and strategies for a receiver oriented dual-axis tracking toroidal heliostat

    Energy Technology Data Exchange (ETDEWEB)

    Guo, Minghuan; Wang, Zhifeng; Liang, Wenfeng; Zhang, Xiliang; Zang, Chuncheng [Key Laboratory of Solar Thermal Energy and Photovoltaic System of Chinese Academy of Sciences, Institute of Electrical Engineering, Beijing 100190 (China); Lu, Zhenwu; Wei, Xiudong [Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences (CAS), Jilin 130033 (China)

    2010-06-15

    A 4 m x 4 m toroidal heliostat with receiver oriented dual-axis tracking, also called spinning-elevation tracking, was developed as an auxiliary heat source for a hydrogen production system. A series of spinning-elevation tracking formulas have been derived for this heliostat. This included basic tracking formulas, a formula for the elevation angle for heliostat with a mirror-pivot offset, and a more general formula for the biased elevation angle. This paper presents the new tracking formulas in detail and analyzes the accuracy of applying a simplifying approximation. The numerical results show these receiver oriented dual-axis tracking formula approximations are accurate to within 2.5 x 10{sup -6} m in image plane. Some practical tracking strategies are discussed briefly. Solar images from the toroidal heliostat at selected times are also presented. (author)

  1. Experimental study of toroidicity-induced Alfven eigenmode (TAE) stability at high q(0)

    Energy Technology Data Exchange (ETDEWEB)

    Batha, S.H.; Levinton, F.M. [Fusion Physics and Technology, Torrance, CA (United States); Spong, D.A. [Oak Ridge National Lab., TN (United States)] [and others

    1995-07-01

    Experiments to destabilize the Toroidicity-induced Alfven Eigenmode (TAE) by energetic alpha particles were performed on the Tokamak Fusion Test Reactor using deuterium and tritium fuel. To decrease the alpha particle pressure instability threshold, discharges with an elevated value of q(0) > 1.5 were used. By raising q(0), the radial location of the low toroidal-mode-number TAE gaps moves toward the magnetic axis and into alignment with the region of maximum alpha pressure gradient, thereby (in theory) lowering the value of {beta}{sub {alpha}}(0) required for instability. No TAE activity was observed when the central alpha particle {beta}{sub {alpha}} reached 0.08% in a discharge with fusion power of 2.4 MW. Calculations show that the fusion power is within a factor of 1.5 to 3 of the instability threshold.

  2. Evaluation of toroidal torque by non-resonant magnetic perturbations in tokamaks for resonant transport regimes using a Hamiltonian approach

    CERN Document Server

    Albert, Christopher G; Kapper, Gernot; Kasilov, Sergei V; Kernbichler, Winfried; Martitsch, Andreas F

    2016-01-01

    Toroidal torque generated by neoclassical viscosity caused by external non-resonant, non-axisymmetric perturbations has a significant influence on toroidal plasma rotation in tokamaks. In this article, a derivation for the expressions of toroidal torque and radial transport in resonant regimes is provided within quasilinear theory in canonical action-angle variables. The proposed approach treats all low-collisional quasilinear resonant NTV regimes including superbanana plateau and drift-orbit resonances in a unified way and allows for magnetic drift in all regimes. It is valid for perturbations on toroidally symmetric flux surfaces of the unperturbed equilibrium without specific assumptions on geometry or aspect ratio. The resulting expressions are shown to match existing analytical results in the large aspect ratio limit. Numerical results from the newly developed code NEO-RT are compared to calculations by the quasilinear version of the code NEO-2 at low collisionalities. The importance of the magnetic shea...

  3. Toroidally Resolved Structure of Divertor Heat Flux in RMP H-mode Discharges on DIII-D

    Energy Technology Data Exchange (ETDEWEB)

    Jakubowski, M. W. [Max-Planck-Institute for Plasmaphysik, EURATOM-Association, Greifswald, Germany; Evans, T.E. [General Atomics, San Diego; Fenstermacher, M. E. [Lawrence Livermore National Laboratory (LLNL); Lasnier, C. J. [Lawrence Livermore National Laboratory (LLNL); Wolf, R. C. [Max-Planck-Institute for Plasmaphysik, EURATOM-Association, Greifswald, Germany; Baylor, Larry R [ORNL; Boedo, J.A. [University of California, San Diego; Burrell, K. H. [General Atomics; DeGrassie, J. S. [General Atomics, San Diego; Gohil, P. [General Atomics; Mordijck, S. [University of California, San Diego; Laengner, R. [Forschungszentrum Julich, Julich, Germany; Leonard, A. W. [General Atomics; Moyer, R.A. [University of California, San Diego; Petrie, T. W. [General Atomics, San Diego; Petty, C C. [General Atomics, San Diego; Pinsker, R. I. [General Atomics, San Diego; Rhodes, T. L. [University of California, Los Angeles; Schaffer, M. J. [General Atomics, San Diego; Schmitz, O. [Forschungszentrum Julich, Julich, Germany; Snyder, P. B. [General Atomics; Stoschus, H. [EURATOM / FZ-Juelich, Germany; Osborne, T. H. [General Atomics; Orlov, D. M. [University of California, San Diego & La Jolla; Unterberg, Ezekial A [ORNL; Watkins, J. G. [Sandia National Laboratories (SNL)

    2011-01-01

    As shown on DIII-D edge localized modes (ELMs) can be either completely eliminated or mitigated with resonant magnetic perturbation (RMP) fields. Two infrared cameras, separated 105 degrees toroidally, were used to make simultaneous measurements of ELM heat loads with high frame rates. Without the RMP fields ELMs display a variety of different heat load dynamics and a range of toroidal variability that is characteristic of their 3D structure. Comparing radial averages there is no asymmetry between two toroidal locations. With RMP-mitigated ELMs, the variability in the radially averaged power loads is significantly reduced and toroidal asymmetries in power loads are introduced. In addition to RMP ELM suppression scenarios an RMP scenario with only very small ELMs and very good confinement has been achieved.

  4. High-throughput beamline for attosecond pulses based on toroidal mirrors with microfocusing capabilities.

    Science.gov (United States)

    Frassetto, F; Trabattoni, A; Anumula, S; Sansone, G; Calegari, F; Nisoli, M; Poletto, L

    2014-10-01

    We have developed a novel attosecond beamline designed for attosecond-pump/attosecond probe experiments. Microfocusing of the Extreme-ultraviolet (XUV) radiation is obtained by using a coma-compensated optical configuration based on the use of three toroidal mirrors controlled by a genetic algorithm. Trains of attosecond pulses are generated with a measured peak intensity of about 3 × 10(11) W/cm(2).

  5. Particle Simulation Code for the Electron Temperature Gradient Instability in Tokamak Toroidal Plasmas

    Institute of Scientific and Technical Information of China (English)

    JIANGuangde; DONGJiaqi

    2003-01-01

    A numerical simulation code has been established with particle simulation method in order to study the gyro-kinetic equations for the electrostatic electron temperature gradient modes in toroidal plasmas. The flowchart is given as well for the code. The fourth-order adaptive step-size scheme is adopted, that saves computer time and is simple. The calculation code is useful for the research of the electron temperature gradient instability.

  6. Topological symmetry breaking of self-interacting fractional Klein-Gordon field theories on toroidal spacetime

    Energy Technology Data Exchange (ETDEWEB)

    Lim, S C [Faculty of Engineering, Multimedia University, Jalan Multimedia, Cyberjaya, 63100, Selangor Darul Ehsan (Malaysia); Teo, L P [Faculty of Information Technology, Multimedia University, Jalan Multimedia, Cyberjaya, 63100, Selangor Darul Ehsan (Malaysia)], E-mail: sclim@mmu.edu.my, E-mail: lpteo@mmu.edu.my

    2008-04-11

    Quartic self-interacting fractional Klein-Gordon scalar massive and massless field theories on toroidal spacetime are studied. The effective potential and topologically generated mass are determined using zeta-function regularization technique. Renormalization of these quantities are derived. Conditions for symmetry breaking are obtained analytically. Simulations are carried out to illustrate regions or values of compactified dimensions where symmetry-breaking mechanisms appear.

  7. Zonal Flow Patterns: How Toroidal Coupling Induces Phase Jumps and Shear Layers

    CERN Document Server

    Guo, Z B

    2016-01-01

    A new, frequency modulation mechanism for zonal flow pattern formation is presented. The model predicts the probability distribution function of the flow strength as well as the evolution of the characteristic spatial scale. Magnetic toroidicity-induced global phase dynamics is shown to determine the spatial structure of the flow. A key result is the observation that global phase patterning can lead to zonal flow formation in the absence of turbulence inhomogeneity.

  8. High-throughput beamline for attosecond pulses based on toroidal mirrors with microfocusing capabilities

    Energy Technology Data Exchange (ETDEWEB)

    Frassetto, F.; Poletto, L., E-mail: poletto@dei.unipd.it [National Research Council, Institute of Photonics and Nanotechnologies, via Trasea 7, 35131 Padova (Italy); Trabattoni, A.; Anumula, S.; Sansone, G. [Department of Physics, Politecnico di Milano, Piazza L. Da Vinci 32, 20133 Milano (Italy); Calegari, F. [National Research Council, Institute of Photonics and Nanotechnologies, Piazza L. da Vinci 32, 20133 Milano (Italy); Nisoli, M. [Department of Physics, Politecnico di Milano, Piazza L. Da Vinci 32, 20133 Milano (Italy); National Research Council, Institute of Photonics and Nanotechnologies, Piazza L. da Vinci 32, 20133 Milano (Italy)

    2014-10-15

    We have developed a novel attosecond beamline designed for attosecond-pump/attosecond probe experiments. Microfocusing of the Extreme-ultraviolet (XUV) radiation is obtained by using a coma-compensated optical configuration based on the use of three toroidal mirrors controlled by a genetic algorithm. Trains of attosecond pulses are generated with a measured peak intensity of about 3 × 10{sup 11} W/cm{sup 2}.

  9. Stability analysis of toroidicity-induced Alfven eigenmodes in TFTR DT experiments

    Energy Technology Data Exchange (ETDEWEB)

    Fu, G.Y.; Cheng, C.Z.; Budny, R.; Chang, Z.; Darrow, D.S.; Fredrickson, E.; Mazzucato, E.; Nazikian, R.; Zweben, S.

    1995-05-15

    The toroidicity-induced Alfvin eigenmodes (TAE) with radially extended structure are found to be stable in the Tokamak Fusion Test Reactor Deuterium-Tritium plasmas. A core localized TAE mode is shown to exist near the center of the plasma at small magnetic shear and finite plasma beta, which can be destabilized by energetic alpha particles on TFTR. With additional instability drive from fast minority ions powered by ICRH, both the global and the core localized TAE modes can be readily destabilized.

  10. 内质网应激PERK-ATF4-CHOP通路在苦参碱诱导视网膜母细胞瘤细胞凋亡中的作用%Role of Endoplasmic Reticulum Stress PERK-ATF4-CHOP Pathway in Matrine Induced Retinoblastoma Apoptosis

    Institute of Scientific and Technical Information of China (English)

    来小丹; 欧阳净; 石英

    2015-01-01

    Objective To analyze the role of endoplasmic reticulum stress PERK-ATF4-CHOP pathway in matrine induced retinoblastoma cells apoptosis. Methods Different concentrations of 0, 1. 0, 2. 0, 4. 0 g/L matrine was used to treat the HOX-Rb44 cells for 24 h,the cell viability was determined by MTT assay, HOX-RB44 apoptosis situation was determined by ow cytometry,western blot analysis was used to dectect the Bax,Bcl-2,GRP78,GRP94,AFT4,peIF2α and CHOP expression. Results As the increase of concentration of ma-trine,HOX-Rb44 apoptosis rate increased significantly ( P < 0. 05 ) , GRP78 and GRP94 increased significantly, and ATF and PERK downstream peIF2α and CHOP were also increased significantly. Conclusion Matrine could promoted HOX-Rb44 cell apoptosis, endo-plasmic reticulum stress, where PERK-ATF4-CHOP pathway may play an important role.%目的:探讨内质网应激 PERK-ATF4-CHOP通路在苦参碱诱导视网膜母细胞瘤细胞凋亡中的作用。方法采用0,1.0,2.0,4.0 g/L苦参碱处理HOX-Rb44细胞24 h,MTT、流式细胞术分析细胞增殖活性及凋亡情况,Western Blot检测凋亡相关蛋白Bax,Bcl-2,内质网应激相关蛋白GRP94,GRP78,ATF4以及PERK下游peIF2α及CHOP蛋白表达水平。结果随着苦参碱质量浓度的增加,HOX-Rb44细胞增殖抑制增加,凋亡率显著升高( P<0.05),GRP78与GRP94的表达水平逐渐升高,ATF及PERK下游peIF2α及CHOP蛋白表达升高。结论苦参碱处理视网膜母细胞瘤细胞能诱导细胞凋亡,内质网应激、PERK-ATF4-CHOP通路可能在其中有重要作用。

  11. New picture of the 1/1 internal kink and sawtooth in compressible toroidal plasmas

    Science.gov (United States)

    Sugiyama, Linda

    2013-10-01

    The m = 1 , n = 1 internal kink mode and the sawtooth crash have been analyzed extensively in magnetically confined toroidal plasmas. Nevertheless, many questions remain. A new analysis, with the aid of numerical simulation, shows that small parameter expansions such as large aspect ratio break down in general for the MHD compressible toroidal 1/1 instability with realistically small growth rates. The perpendicular momentum rate of change ρ ∂v⊥ / ∂ t must be very small compared to the individual terms in - ρ (v . ∇) v |⊥ + J × B |⊥ -∇⊥ p . The lowest order mode still has the standard 1/1 internal kink form, but the v⊥ magnitude and growth rate are determined by the higher order terms. Terms containing B~ϕ , nominally associated with the compressional Alfvén wave are important. One corollary is that reduced MHD (RMHD) fails completely and Sweet-Parker-type reconnection never develops. At a critical nonlinear amplitude, associated with the growth of the higher toroidal harmonics, a fast, explosive crash begins with rapidly accelerating velocity growth that matches observations. Other transverse MHD instabilities experience analogous effects. Work supported by the U.S. Department of Energy.

  12. The turbulent diffusion of toroidal magnetic flux as inferred from properties of the sunspot butterfly diagram

    CERN Document Server

    Cameron, R H

    2016-01-01

    In order to match observed properties of the solar cycle, flux-transport dynamo models require the toroidal magnetic flux to be stored in a region of low magnetic diffusivity, typically located at or below the bottom of the convection zone. We infer the turbulent magnetic diffusivity affecting the toroidal field on the basis of empirical data. We consider the time evolution of mean latitude and width of the activity belts of solar cycles 12--23 and their dependence on cycle strength. We interpret the decline phase of the cycles as a diffusion process. The activity level of a given cycle begins to decline when the centers of its equatorward propagating activity belts come within their width (at half maximum) from the equator. This happens earlier for stronger cycles because their activity belts are wider. From that moment on, the activity and the belt width decrease in the same manner for all cycles, independent of their maximum activity level. In terms of diffusive cancellation of opposite-polarity toroidal f...

  13. Equilibrium poloidal field distributions in reversed-field-pinch toroidal discharges

    Energy Technology Data Exchange (ETDEWEB)

    Baker, D.A.; Mann, L.W.; Schoenberg, K.F.

    1982-04-01

    A comparison between the analytic formulae of Shafranov for equilibrium in axisymmetric toroidal reversed field pinch (RFP) systems and fully toroidal numerical solutions of the Grad-Shafranov equation is presented as a function of poloidal beta, internal plasma inductance, and aspect ratio. The Shafranov formula for the equilibrium poloidal field distribution is accurate to within 5% for aspect ratios greater than 2, poloidal betas less than 50%, and for plasma current channels that exceed one-third of the minor toroidal radius. The analytic description for the center shift of the innermost flux surface that encloses the plasma current (the Shafranov shift) is accurate to within 15% for aspect ratios greater than 2 and poloidal betas below 50%, provided the shift does not exceed one-tenth of the minor conducting boundary radius. The behavior of the magnetic axis shift as a function of plasma parameters is included. The Shafranov formulae provide a convenient method for describing the equilibrium behavior of an RFP discharge. Examples illustrating the application of the analytic formulae to the Los Alamos ZT-40M RFP experiment are given.

  14. Bifurcation physics of magnetic islands and stochasticity explored by heat pulse propagation studies in toroidal plasmas

    Science.gov (United States)

    Ida, K.; Kobayashi, T.; Yoshinuma, M.; Suzuki, Y.; Narushima, Y.; Evans, T. E.; Ohdachi, S.; Tsuchiya, H.; Inagaki, S.; Itoh, K.

    2016-09-01

    Bifurcation physics of a magnetic island was investigated using the heat pulse propagation technique produced by the modulation of electron cyclotron heating. There are two types of bifurcation phenomena observed in a large helical device (LHD) and DIII-D. One is a bifurcation of the magnetic topology between nested and stochastic fields. The nested state is characterized by the bi-directional (inward and outward) propagation of the heat pulse with slow propagation speed. The stochastic state is characterized by the fast propagation of the heat pulse with electron temperature flattening. The other bifurcation is between the magnetic island with larger thermal diffusivity and that with smaller thermal diffusivity. The damping of toroidal flow is observed at the O-point of the magnetic island both in helical plasmas and in tokamak plasmas during a mode locking phase with strong flow shears at the boundary of the magnetic island. Associated with the stochastization of the magnetic field, the abrupt damping of toroidal flow is observed in LHD. The toroidal flow shear shows a linear decay, while the ion temperature gradient shows an exponential decay. This observation suggests that this flow damping is due to the change in the non-diffusive term of momentum transport.

  15. The linear tearing instability in three dimensional, toroidal gyro-kinetic simulations

    Energy Technology Data Exchange (ETDEWEB)

    Hornsby, W. A., E-mail: william.hornsby@ipp.mpg.de; Migliano, P.; Buchholz, R.; Kroenert, L.; Weikl, A.; Peeters, A. G. [Theoretical Physics V, Department of Physics, Universitaet Bayreuth, Bayreuth D-95447 (Germany); Zarzoso, D.; Poli, E. [Max-Planck-Institut für Plasmaphysik, Boltzmannstrasse 2, D-85748 Garching bei München (Germany); Casson, F. J. [CCFE, Culham Science Centre, Abingdon, Oxon OX14 3DB (United Kingdom)

    2015-02-15

    Linear gyro-kinetic simulations of the classical tearing mode in three-dimensional toroidal geometry were performed using the global gyro-kinetic turbulence code, GKW. The results were benchmarked against a cylindrical ideal MHD and analytical theory calculations. The stability, growth rate, and frequency of the mode were investigated by varying the current profile, collisionality, and the pressure gradients. Both collisionless and semi-collisional tearing modes were found with a smooth transition between the two. A residual, finite, rotation frequency of the mode even in the absence of a pressure gradient is observed, which is attributed to toroidal finite Larmor-radius effects. When a pressure gradient is present at low collisionality, the mode rotates at the expected electron diamagnetic frequency. However, the island rotation reverses direction at high collisionality. The growth rate is found to follow a η{sup 1∕7} scaling with collisional resistivity in the semi-collisional regime, closely following the semi-collisional scaling found by Fitzpatrick. The stability of the mode closely follows the stability analysis as performed by Hastie et al. using the same current and safety factor profiles but for cylindrical geometry, however, here a modification due to toroidal coupling and pressure effects is seen.

  16. Twisted toroidal vortex-solitons in inhomogeneous media with repulsive nonlinearity

    CERN Document Server

    Kartashov, Y V; Shnir, Y; Torner, L

    2014-01-01

    Toroidal modes in the form of so-called Hopfions, with two independent winding numbers, a hidden one (twist, s), which characterizes a circular vortex thread embedded into a three-dimensional soliton, and the vorticity around the vertical axis m, appear in many fields, including the field theory, ferromagnetics, and semi- and superconductors. Such topological states are normally generated in multi-component systems, or as trapped quasi-linear modes in toroidal potentials. We uncover that stable solitons with this structure can be created, without any linear potential, in the single-component setting with the strength of repulsive nonlinearity growing fast enough from the center to the periphery, for both steep and smooth modulation profiles. Toroidal modes with s=1 and vorticity m=0,1,2 are produced. They are stable for m1. An approximate analytical solution is obtained for the twisted ring with s=1, m=0. Under the application of an external torque, it rotates like a solid ring. The setting can be implemented...

  17. Three-dimensional neutron source models for toroidal fusion energy systems

    Energy Technology Data Exchange (ETDEWEB)

    Slaybaugh, R.N. [Fusion Technology Institute, University of Wisconsin, 1500 Engineering Dr., Madison, WI 53706 (United States)], E-mail: slaybaugh@wisc.edu; Wilson, P.P.H. [Fusion Technology Institute, University of Wisconsin, 1500 Engineering Dr., Madison, WI 53706 (United States)], E-mail: wilsonp@engr.wisc.edu; El-Guebaly, L.A.; Marriott, E.P. [Fusion Technology Institute, University of Wisconsin, 1500 Engineering Dr., Madison, WI 53706 (United States)

    2009-06-15

    Developments in computer architecture and neutronics code capabilities have enabled high-resolution analysis of complex 3D geometries. Thus, accurately modeling 3D source distributions has become important for nuclear analyses. In this work two methods are described which generate and sample such 3D sources based directly on the plasma parameters of a fusion device and which facilitate the ability to update the neutron source following changes to the plasma physics configuration. The cylindrical mesh method is for toroidally symmetric machines and utilizes data in a standard file format which represents the poloidal magnetic flux on an R-Z grid. The conformal hexahedral mesh method takes plasma physics data generated in an idealized toroidal coordinate system and uses a Jacobian transformation and a functional expansion to generate the source. This work describes each methodology and associated test cases. The cylindrical mesh method was applied to ARIES-RS and the conformal hexahedral mesh method was applied to a uniform torus and ARIES-CS. The results of the test cases indicate that these improved source definitions can have important effects on pertinent engineering parameters, such as neutron wall loading, and should therefore be used for high-resolution nuclear analyses of all toroidal devices.

  18. New Superconducting Toroidal Magnet System for IAXO, the International AXion Observatory

    CERN Document Server

    Shilon, I; Silva, H; Wagner, U; Kate, H H J ten

    2013-01-01

    Axions are hypothetical particles that were postulated to solve one of the puzzles arising in the standard model of particle physics, namely the strong CP (Charge conjugation and Parity) problem. The new International AXion Observatory (IAXO) will incorporate the most promising solar axions detector to date, which is designed to enhance the sensitivity to the axion-photon coupling by one order of magnitude beyond the limits of the current state-of-the-art detector, the CERN Axion Solar Telescope (CAST). The IAXO detector relies on a high-magnetic field distributed over a very large volume to convert solar axions into X-ray photons. Inspired by the successful realization of the ATLAS barrel and end-cap toroids, a very large superconducting toroid is currently designed at CERN to provide the required magnetic field. This toroid will comprise eight, one meter wide and twenty one meter long, racetrack coils. The system is sized 5.2 m in diameter and 25 m in length. Its peak magnetic field is 5.4 T with a stored e...

  19. PERK-eIF2α-ATF4 pathway mediated by endoplasmic reticulum stress response is involved in osteodifferentiation of human periodontal ligament cells under cyclic mechanical force.

    Science.gov (United States)

    Yang, Shuang-Yan; Wei, Fu-Lan; Hu, Li-Hua; Wang, Chun-Ling

    2016-08-01

    To prevent excess accumulation of unfolded proteins in endoplasmic reticulum (ER), eukaryotic cells have signaling pathways from the ER to the cytosol or nucleus. These processes are known as the endoplasmic reticulum stress (ERS) response. Protein kinase R like endoplasmic reticulum kinase (PERK) is a major transducer of the ERS response and it directly phosphorylate α-subunit of eukaryotic initiation factor 2 (eIF2α), resulting in translational attenuation. Phosphorylated eIF2α specifically promoted the translation of the activating transcription factor 4 (ATF4). ATF4 is a known important transcription factor which plays a pivotal role in osteoblast differentiation and bone formation. Furthermore, ATF4 is a downstream target of PERK. Studies have shown that PERK-eIF2α-ATF4 signal pathway mediated by ERS was involved in osteoblastic differentiation of osteoblasts. We have known that orthodontic tooth movement is a process of periodontal ligament cells (PDLCs) osteodifferentiation and alveolar bone remodeling under mechanical force. However, the involvement of PERK-eIF2α-ATF4 signal pathway mediated by ERS in osteogenic differentiation of PDLCs under mechanical force has not been unclear. In our study, we applied the cyclic mechanical force at 10% elongation with 0.5Hz to mimic occlusal force, and explored whether PERK-eIF2α-ATF4 signaling pathway mediated by ERS involved in osteogenic differentiation of PDLCs under mechanical force. Firstly, cyclic mechanical force will induce ERS and intensify several osteoblast marker genes (ATF4, OCN, and BSP). Next, we found that PERK overexpression increased eIF2α phosphorylation and expression of ATF4, furthermore induced BSP, OCN expression, thus it will promote osteodifferentiation of hPDLCs; mechanical force could promote this effect. However, PERK(-/-) cells showed the opposite changes, which will inhibit osteodifferentiation of hPDLCs. Taken together, our study proved that PERK-eIF2α-ATF4 signaling pathway

  20. A Low-Protein, High-Carbohydrate Diet Stimulates Thermogenesis in the Brown Adipose Tissue of Rats via ATF-2.

    Science.gov (United States)

    de França, Suélem A; dos Santos, Maísa P; Przygodda, Franciele; Garófalo, Maria Antonieta R; Kettelhut, Isis C; Magalhães, Diego A; Bezerra, Kalinne S; Colodel, Edson M; Flouris, Andreas D; Andrade, Cláudia M B; Kawashita, Nair H

    2016-03-01

    The aim of this study was to evaluate thermogenesis in the interscapular brown adipose tissue (IBAT) of rats submitted to low-protein, high-carbohydrate (LPHC) diet and the involvement of adrenergic stimulation in this process. Male rats (~100 g) were submitted to LPHC (6%-protein; 74%-carbohydrate) or control (C; 17%-protein; 63%-carbohydrate) isocaloric diets for 15 days. The IBAT temperature was evaluated in the rats before and after the administration of noradrenaline (NA) (20 µg 100 g b w(-1) min(-1)). The expression levels of uncoupling protein 1 (UCP1) and other proteins involved in the regulation of UCP1 expression were determined by Western blot (Student's t test, P ≤ 0.05). The LPHC diet promoted a 1.1 °C increase in the basal temperature of IBAT when compared with the basal temperature in the IBAT of the C group. NA administration promoted a 0.3 °C increase in basal temperature in the IBAT of the C rats and a 0.5 °C increase in the IBAT of the LPHC group. The level of UCP1 increased 60% in the IBAT of LPHC-fed rats, and among the proteins involved in its expression, such as β3-AR and α1-AR, there was a 40% increase in the levels of p38-MAPK and a 30% decrease in CREB when compared to the C rats. The higher sympathetic flux to IBAT, which is a consequence of the administration of the LPHC diet to rats, activates thermogenesis and increases the expression of UCP1 in the tissue. Our results suggest that the increase in UCP1 content may occur via p38 MAPK and ATF2.

  1. Numerical Simulation of Non-Inductive Startup of the Pegasus Toroidal Experiment

    Science.gov (United States)

    O'Bryan, John B.

    The dynamics and relaxation of magnetic flux ropes produced during non-inductive startup of the Pegasus Toroidal Experiment are simulated with nonlinear magnetohydrodynamic and two-fluid plasma models. A current filament is produced by a single injector and directed along multiple passes by toroidal and vertical vacuum magnetic field components. Adjacent passes of the current filament merge and reconnect, releasing an axisymmetric current ring from the driven channel. Squashing degree analysis indicates the presence of a quasi-separatrix layer (QSL) during ring formation, but the QSL does not solely correspond to magnetic reconnection. Chaotic scattering is also apparent from the distribution of magnetic field-line lengths. The merging of adjacent passes constitutes coherent dynamo action that affects the toroidally-averaged magnetic-field distribution. The MHD dynamo--primarily from the vertical displacement of the current channel--concentrates symmetric poloidal flux and transfers significant energy to the forming flux-rope ring. Accumulation of poloidal flux over many reconnection events contributes to the development of a poloidal magnetic field null near the central column that redirects the driven current filament, such that its path traces a toroidal surface. After cessation of the simulated current drive, temperature and current profiles broaden and closed flux surfaces form rapidly and encompass a large plasma volume. High toroidal-mode number harmonics of the magnetic energy decay preferentially, leaving a tokamak-like plasma suitable for transition to other forms of current drive. Computations with the two-fluid terms in Ohm's Law produce qualitatively similar plasma evolution to the MHD computations. However, for the computations with the two-fluid plasma model, the ion fluid significantly decouples from the electron fluid, weakening the dynamics during magnetic reconnection. This effect is quantified by comparing global and local plasma parameters in

  2. Toroidal, Counter-Toroidal, and Upwelling Flow in the Mantle Wedge of the Rivera and Cocos Plates: Implications for IOB Geochemistry in the Trans-Mexican Volcanic Belt

    Science.gov (United States)

    Neumann, Florian; Vásquez-Serrano, Alberto; Tolson, Gustavo; Negrete-Aranda, Raquel; Contreras, Juan

    2015-12-01

    We carried out analog laboratory modeling at a scale 1:4,000,000 and computer rendering of the flow patterns in a simulated western Middle American subduction zone. The scaled model consists of a transparent tank filled with corn syrup and housing two conveyor belts made of polyethylene strips. One of the strips dips 60° and moves at a velocity of 30 mm/min simulating the Rivera plate. The other one dips 45°, moves at 90 mm/min simulating the subduction of the Cocos plate. Our scaled subduction zone also includes a gap between the simulated slabs analogous to a tear recently observed in shear wave tomography studies. An acrylic plate 3 mm thick floats on the syrup in grazing contact with the polyethylene strips and simulates the overriding North America plate. Our experiments reveal a deep toroidal flow of asthenospheric mantle through the Cocos-Rivera separation. The flow is driven by a pressure gradient associated with the down-dip differential-motion of the slabs. Similarly, low pressure generated by the fast-moving Cocos plate creates a shallow counter-toroidal flow in the uppermost 100 km of the mantle wedge. The flow draws mantle beneath the western Trans-Mexican Volcanic Belt to the Jalisco block, then plunges into the deep mantle by the descending poloidal cell of the Cocos slab. Moreover, our model suggests a hydraulic jump causes an ~250 km asthenosphere upwelling around the area where intra-arc extensional systems converge in western Mexico. The upwelling eventually merges with the shallow counter-toroidal flow describing a motion in 3D space similar to an Archimedes' screw. Our results indicate the differential motion between subducting slabs drives mixing in the mantle wedge of the Rivera plate and allows the slab to steepen and retreat. Model results are in good agreement with seismic anisotropy studies and the geochemistry of lavas erupted in the Jalisco block. The model can explain the eruption of OIB lavas in the vicinity of the City of

  3. Toroidal, Counter-Toroidal, and Upwelling Flow in the Mantle Wedge of the Rivera and Cocos Plates: Implications for IOB Geochemistry in the Trans-Mexican Volcanic Belt

    Science.gov (United States)

    Neumann, Florian; Vásquez-Serrano, Alberto; Tolson, Gustavo; Negrete-Aranda, Raquel; Contreras, Juan

    2016-10-01

    We carried out analog laboratory modeling at a scale 1:4,000,000 and computer rendering of the flow patterns in a simulated western Middle American subduction zone. The scaled model consists of a transparent tank filled with corn syrup and housing two conveyor belts made of polyethylene strips. One of the strips dips 60° and moves at a velocity of 30 mm/min simulating the Rivera plate. The other one dips 45°, moves at 90 mm/min simulating the subduction of the Cocos plate. Our scaled subduction zone also includes a gap between the simulated slabs analogous to a tear recently observed in shear wave tomography studies. An acrylic plate 3 mm thick floats on the syrup in grazing contact with the polyethylene strips and simulates the overriding North America plate. Our experiments reveal a deep toroidal flow of asthenospheric mantle through the Cocos-Rivera separation. The flow is driven by a pressure gradient associated with the down-dip differential-motion of the slabs. Similarly, low pressure generated by the fast-moving Cocos plate creates a shallow counter-toroidal flow in the uppermost 100 km of the mantle wedge. The flow draws mantle beneath the western Trans-Mexican Volcanic Belt to the Jalisco block, then plunges into the deep mantle by the descending poloidal cell of the Cocos slab. Moreover, our model suggests a hydraulic jump causes an ~250 km asthenosphere upwelling around the area where intra-arc extensional systems converge in western Mexico. The upwelling eventually merges with the shallow counter-toroidal flow describing a motion in 3D space similar to an Archimedes' screw. Our results indicate the differential motion between subducting slabs drives mixing in the mantle wedge of the Rivera plate and allows the slab to steepen and retreat. Model results are in good agreement with seismic anisotropy studies and the geochemistry of lavas erupted in the Jalisco block. The model can explain the eruption of OIB lavas in the vicinity of the City of

  4. Dehydroepiandrosterone sulfate mediates activation of transcription factors CREB and ATF-1 via a Gα11-coupled receptor in the spermatogenic cell line GC-2.

    Science.gov (United States)

    Shihan, Mazen; Kirch, Ulrike; Scheiner-Bobis, Georgios

    2013-12-01

    Dehydroepiandrosterone sulfate (DHEAS) is a circulating steroid produced in the adrenal cortex, brain, and gonads. Whereas a series of investigations attest to neuroprotective effects of the steroid in the brain, surprisingly little is known about the physiological effects of DHEAS on cells of the reproductive system. Here we demonstrate that DHEAS acting on the spermatogenic cell line GC-2 induces a time- and concentration-dependent phosphorylation of c-Src and Erk1/2 and activates the transcription factors activating transforming factor-1 (ATF-1) and cyclic AMP-responsive element binding protein (CREB). These actions are consistent with the non-classical signaling pathway of testosterone and suggest that DHEAS is a pro-androgen that is converted into testosterone in order to exert its biological activity. The fact, however, that steroid sulfatase mRNA was not detected in the GC-2 cells and the clear demonstration of DHEAS-induced activation of Erk1/2, ATF-1 and CREB after silencing the androgen receptor by small interfering RNA (siRNA) clearly contradict this assumption and make it appear unlikely that DHEAS has to be converted in the cytosol into a different steroid in order to activate the kinases and transcription factors mentioned. Instead, it is likely that the DHEAS-induced signaling is mediated through the interaction of the steroid with a membrane-bound G-protein-coupled receptor, since silencing of Guanine nucleotide-binding protein subunit alpha-11 (Gnα11) leads to the abolition of the DHEAS-induced stimulation of Erk1/2, ATF-1, and CREB. The investigation presented here shows a hormone-like activity of DHEAS on a spermatogenic cell line. Since DHEAS is produced in male and female reproductive organs, these findings could help to define new roles for DHEAS in the physiology of reproduction.

  5. UPR induces transient burst of apoptosis in islets of early lactating rats through reduced AKT phosphorylation via ATF4/CHOP stimulation of TRB3 expression.

    Science.gov (United States)

    Bromati, Carla R; Lellis-Santos, Camilo; Yamanaka, Tatiana S; Nogueira, Tatiane C A; Leonelli, Mauro; Caperuto, Luciana C; Gorjão, Renata; Leite, Adriana R; Anhê, Gabriel F; Bordin, Silvana

    2011-01-01

    Endocrine pancreas from pregnant rats undergoes several adaptations that comprise increase in β-cell number, mass and insulin secretion, and reduction of apoptosis. Lactogens are the main hormones that account for these changes. Maternal pancreas, however, returns to a nonpregnant state just after the delivery. The precise mechanism by which this reversal occurs is not settled but, in spite of high lactogen levels, a transient increase in apoptosis was already reported as early as the 3rd day of lactation (L3). Our results revealed that maternal islets displayed a transient increase in DNA fragmentation at L3, in parallel with decreased RAC-alpha serine/threonine-protein kinase (AKT) phosphorylation (pAKT), a known prosurvival kinase. Wortmannin completely abolished the prosurvival action of prolactin (PRL) in cultured islets. Decreased pAKT in L3-islets correlated with increased Tribble 3 (TRB3) expression, a pseudokinase inhibitor of AKT. PERK and eIF2α phosphorylation transiently increased in islets from rats at the first day after delivery, followed by an increase in immunoglobulin heavy chain-binding protein (BiP), activating transcription factor 4 (ATF4), and C/EBP homologous protein (CHOP) in islets from L3 rats. Chromatin immunoprecipitation (ChIP) and Re-ChIP experiments further confirmed increased binding of the heterodimer ATF4/CHOP to the TRB3 promoter in L3 islets. Treatment with PBA, a chemical chaperone that inhibits UPR, restored pAKT levels and inhibited the increase in apoptosis found in L3. Moreover, PBA reduced CHOP and TRB3 levels in β-cell from L3 rats. Altogether, our study collects compelling evidence that UPR underlies the physiological and transient increase in β-cell apoptosis after delivery. The UPR is likely to counteract prosurvival actions of PRL by reducing pAKT through ATF4/CHOP-induced TRB3 expression.

  6. Activation of the Akt-NF-kappaB pathway by subtilase cytotoxin through the ATF6 branch of the unfolded protein response.

    Science.gov (United States)

    Yamazaki, Hiroaki; Hiramatsu, Nobuhiko; Hayakawa, Kunihiro; Tagawa, Yasuhiro; Okamura, Maro; Ogata, Ryouji; Huang, Tao; Nakajima, Shotaro; Yao, Jian; Paton, Adrienne W; Paton, James C; Kitamura, Masanori

    2009-07-15

    Shiga toxin has the potential to induce expression of inflammation-associated genes, although the underlying mechanisms are not well understood. We examined the effects of subtilase cytotoxin (SubAB), an AB(5) toxin produced by some Shiga toxigenic Escherichia coli, on the activation of NF-kappaB. SubAB is known to be a protease which selectively degrades GRP78/Bip. Treatment of NRK-52E cells with SubAB caused rapid cleavage of GRP78. Following the degradation of GRP78, transient activation of NF-kappaB was observed with a peak at 6-12 h; the activation subsided within 24 h despite the continuous absence of intact GRP78. The activation of NF-kappaB was preceded by transient phosphorylation of Akt. Treatment of the cells with a selective inhibitor of Akt1/2 or an inhibitor of PI3K attenuated SubAB-induced NF-kappaB activation, suggesting that activation of Akt is an event upstream of NF-kappaB. Degradation of GRP78 caused the unfolded protein response (UPR), and inducers of the UPR mimicked the stimulatory effects of SubAB on Akt and NF-kappaB. SubAB triggered the three major branches of the UPR including the IRE1-XBP1, PERK, and ATF6 pathways. Dominant-negative inhibition of IRE1alpha, XBP1, or PERK did not attenuate activation of NF-kappaB by SubAB. In contrast, genetic and pharmacological inhibition of ATF6 significantly suppressed SubAB-triggered Akt phosphorylation and NF-kappaB activation. These results suggested that loss of GRP78 by SubAB leads to transient phosphorylation of Akt and consequent activation of NF-kappaB through the ATF6 branch of the UPR.

  7. New dual gas puff imaging system with up-down symmetry on experimental advanced superconducting tokamak

    DEFF Research Database (Denmark)

    Liu, S. C.; Shao, L. M.; Zweben, S. J.;

    2012-01-01

    advanced superconducting tokamak (EAST). The two views are up-down symmetric about the midplane and separated by a toroidal angle of 66.6 degrees. A linear manifold with 16 holes apart by 10 mm is used to form helium gas cloud at the 130x130 mm (radial versus poloidal) objective plane. A fast camera...

  8. Toroidal Variable-Line-Space Gratings: The Good, the Bad and The Ugly

    Science.gov (United States)

    West, Edward A.; Kobayashi, Ken; Cirtain, Jonathan; Gary, Allen; Davis, John; Reader, Joseph

    2009-01-01

    Toroidal variable-line-space (VLS) gratings are an important factor in the design of an efficient VUV solar telescope that will measure the CIV (155nm) and MgII (280nm) emissions lines in the Sun's transition region. In 1983 Kita and Harada described spherical VLS gratings but the technology to commercially fabricate these devices is a recent development, especially for toroidal surfaces. This paper will describe why this technology is important in the development of the Solar Ultraviolet Magnetograph Investigation (SUMI) sounding rocket program (the good), the delays due to the conversion between the TVLS grating design and the optical fabrication (the bad), and finally the optical testing, alignment and tolerancing of the gratings (the ugly). The Solar Ultraviolet Magnetograph Investigation, SUMI, has been reported in several papers since this program began in 2000. The emphasis of this paper is to describe SUMI's Toroidal Variable-Line-Space (TVLS) gratings. These gratings help SUMI meet its scientific goals which require both high spectral resolution and high optical efficiency for magnetic field measurements in the vacuum ultraviolet wavelength band of the solar spectrum (the good). Unfortunately, the technology readiness level of these gratings has made their implementation difficult, especially for a sounding rocket payload (the bad). Therefore, this paper emphasizes the problems and solutions that were developed to use these gratings in SUMI (the ugly). Section 2 contains a short review of the scientific goals of SUMI and why this mission is important in the understanding of the 3D structure of the magnetic field on the Sun. The flight hardware that makes up the SUMI payload is described in Section 3 with emphasis on those components that affect the TVLS gratings. Section 4 emphasizes the alignment, testing and optical modeling that were developed to optimize the performance of these gratings.

  9. Neoclassical toroidal torque generation by auxiliary heating in non-axisymmetric tori

    Science.gov (United States)

    Lazzaro, E.; Nowak, S.; Sauter, O.

    2016-12-01

    In conditions of ideal axisymmetry, for a magnetized plasma in a generic bounded domain, necessarily toroidal, the uniform absorption of external energy (e.g. rf or isotropic alpha heating) clearly cannot give rise to net forces or torques. A rather common experimental observation on contemporary tokamaks is that the near central absorption of auxiliary heating power (often ICH, ECH, and LHCD) and current drive in presence of non axisymmetric magnetic perturbations, including tearing modes, drives a bulk plasma rotation in the co  -  I p direction. Also growing tearing modes provide a nonlinear magnetic braking that tends to flatten the rotation profile and clamp it at the q-rational surfaces. The physical origin of the torque associated with P aux absorption could be due the effects of asymmetry in deposition or in the equilibrium configuration, but here we consider also the effect of the response of the so called neoclassical offset velocity to the power dependent heat flow increment. The neoclassical toroidal viscosity (NTV), due to error fields, internal magnetic kink or tearing modes tends to relax the plasma rotation to this asymptotic speed, which in absence of auxiliary heating is of the order of the ion diamagnetic velocity. It can be shown by a kinetic calculation, this offset velocity is a function of the absorbed heat and therefore of the injected auxiliary power, thereby forcing the plasma rotation in a direction opposite to the initial, to large values. The problem is discussed in the frame of the theoretical models of neoclassical toroidal viscosity.

  10. Evaluation of toroidal torque by non-resonant magnetic perturbations in tokamaks for resonant transport regimes using a Hamiltonian approach

    Science.gov (United States)

    Albert, Christopher G.; Heyn, Martin F.; Kapper, Gernot; Kasilov, Sergei V.; Kernbichler, Winfried; Martitsch, Andreas F.

    2016-08-01

    Toroidal torque generated by neoclassical viscosity caused by external non-resonant, non-axisymmetric perturbations has a significant influence on toroidal plasma rotation in tokamaks. In this article, a derivation for the expressions of toroidal torque and radial transport in resonant regimes is provided within quasilinear theory in canonical action-angle variables. The proposed approach treats all low-collisional quasilinear resonant neoclassical toroidal viscosity regimes including superbanana-plateau and drift-orbit resonances in a unified way and allows for magnetic drift in all regimes. It is valid for perturbations on toroidally symmetric flux surfaces of the unperturbed equilibrium without specific assumptions on geometry or aspect ratio. The resulting expressions are shown to match the existing analytical results in the large aspect ratio limit. Numerical results from the newly developed code NEO-RT are compared to calculations by the quasilinear version of the code NEO-2 at low collisionalities. The importance of the magnetic shear term in the magnetic drift frequency and a significant effect of the magnetic drift on drift-orbit resonances are demonstrated.

  11. SKF TOROIDAL ROLLER BEARING CARB – PRODUCTIVITY IMPROVEMENT AND MAINTENANCE COST REDUCTION THROUGH RELIABILITY AND SUSTAINABILITY

    Directory of Open Access Journals (Sweden)

    Tiberiu LAURIAN

    2010-06-01

    Full Text Available The CARB bearing is a single row bearing with long, slightly crowned symmetrical rollers. It combines the self-aligning capability of the spherical roller bearing with the unconstrained axial displacement ability of the cylindrical roller bearing. The optimal combination of both raceway profiles provides a favorable load distribution in the bearing, as well as low frictional running. This paper emphasizes the functioning characteristics of the SKF CARB toroidal roller bearing by means of a multibody dynamics simulation. Different conditions like load direction, races relative position or angular misalignment, are taken into consideration.

  12. Summary of US-Japan Exchange 2004 New Directions and Physics for Compact Toroids

    Energy Technology Data Exchange (ETDEWEB)

    Intrator, T; Nagata, M; Hoffman, A; Guo, H; Steinhauer, L; Ryutov, D; Miller, R; Okada, S

    2005-08-15

    This exchange workshop was an open meeting coordinated by the P-24 Plasma Physics Group at Los Alamos National Laboratory. We brought together scientists from institutions in the US and Japan who are researching the various and complementary types of Compact Toroids (CT). Many concepts, including both experimental and theoretical investigations, are represented. The range spans Field Reversed Configuration (FRC), spheromak, Reversed Field Pinch (RFP), spherical tokamaks, linear devices dedicated to fundamental physics studies, and hybrid transitions that bridge multiple configurations. The participants represent facilities on which significant experiments are now underway: FRC Injection experiment (FIX), Translation Confinement experiment (TCS), Nihon-University Compact Torus Experiment (NUCTE), HITSI (Helicity Injection experiment, Steady Inductive Helicity Injection (HIT-SIHI)), Field Reversed Configuration experiment-Liner (FRX-L), TS-3/4, Sustained Spheromak Experiment (SSPX), Relaxation Scaling Experiment (RSX), HIST, Caltech Spheromak, or in the design process such as MRX-FRC (PPPL), Pulsed High Density experiment (PHD at UW). Several new directions and results in compact toroid (CT) research have recently emerged, including neutral-beam injection, rotating magnetic fields, flux build up from Ohmic boost coils, electrostatic helicity injection techniques, CT injection into other large devices, and high density configurations for applications to magnetized target fusion and translational compression of CT's. CT experimental programs in both the US and Japan have also shown substantial progress in the control and sustainment of CT's. Both in theory and experiment, there is increased emphasis on 3D dynamics, which is also related to astrophysical and space physics issues. 3D data visualization is now frequently used for experimental data display. There was much discussion of the effects of weak toroidal fields in FRC's and possible implications

  13. A novel synthetic aperture technique for breast tomography with toroidal arrays

    Energy Technology Data Exchange (ETDEWEB)

    Huang, Lianjie [Los Alamos National Laboratory; Simonetti, Francesco [IMPERIAL COLLEGE

    2009-01-01

    Ultrasound is commonly used as an adjunct to mammography for diagnostic evaluation of suspicions arising from breast cancer screening. As an alternative to conventional sonography that uses hand-held transducers, toroidal array probes that encircle the breast immersed in a water bath have been investigated for ultrasound tomography. This paper introduces a new method for three-dimensional synthetic aperture diffraction tomography that maximizes the resolution in the scanning direction and provides quantitative reconstructions of the acoustic properties of the object. The method is validated by means of numerical simulations.

  14. Demountable Toroidal Field Magnets for Use in a Compact Modular Fusion Reactor

    Science.gov (United States)

    Mangiarotti, F. J.; Goh, J.; Takayasu, M.; Bromberg, L.; Minervini, J. V.; Whyte, D.

    2014-05-01

    A concept of demountable toroidal field magnets for a compact fusion reactor is discussed. The magnets generate a magnetic field of 9.2 T on axis, in a 3.3 m major radius tokamak. Subcooled YBCO conductors have a critical current density adequate to provide this large magnetic field, while operating at 20 K reduces thermodynamic cooling cost of the resistive electrical joints. Demountable magnets allow for vertical replacement and maintenance of internal components, potentially reducing cost and time of maintenance when compared to traditional sector maintenance. Preliminary measurements of contact resistance of a demountable YBCO electrical joint between are presented.

  15. Comparative investigation of ELM control based on toroidal modelling of plasma response to RMP fields

    Science.gov (United States)

    Liu, Yueqiang

    2016-10-01

    The type-I edge localized mode (ELM), bursting at low frequency and with large amplitude, can channel a substantial amount of the plasma thermal energy into the surrounding plasma-facing components in tokamak devices operating at the high-confinement mode, potentially causing severe material damages. Learning effective ways of controlling this instability is thus an urgent issue in fusion research, in particular in view of the next generation large devices such as ITER and DEMO. Among other means, externally applied, three-dimensional resonant magnetic perturbation (RMP) fields have been experimentally demonstrated to be successful in mitigating or suppressing the type-I ELM, in multiple existing devices. In this work, we shall report results of a comparative study of ELM control using RMPs. Comparison is made between the modelled plasma response to the 3D external fields and the observed change of the ELM behaviour on multiple devices, including MAST, ASDEX Upgrade, EAST, DIII-D, JET, and KSTAR. We show that toroidal modelling of the plasma response, based on linear and quasi-linear magnetohydrodynamic (MHD) models, provides essential insights that are useful in interpreting and guiding the ELM control experiments. In particular, linear toroidal modelling results, using the MARS-F code, reveal the crucial role of the edge localized peeling-tearing mode response during ELM mitigation/suppression on all these devices. Such response often leads to strong peaking of the plasma surface displacement near the region of weak equilibrium poloidal field (e.g. the X-point), and this provides an alternative practical criterion for ELM control, as opposed to the vacuum field based Chirikov criteria. Quasi-linear modelling using MARS-Q provides quantitative interpretation of the side effects due to the ELM control coils, on the plasma toroidal momentum and particle confinements. The particular role of the momentum and particle fluxes, associated with the neoclassical toroidal

  16. Nonaxisymmetric Rossby vortex instability with toroidal magnetic fields in structured disks

    Energy Technology Data Exchange (ETDEWEB)

    Yu, Cong [Los Alamos National Laboratory; Li, Hui [Los Alamos National Laboratory

    2009-01-01

    We investigate the global nonaxisymmetric Rossby vortex instability (RVI) in a differentially rotating, compressible magnetized accretion disk with radial density structures. Equilibrium magnetic fields are assumed to have only the toroidal component. Using linear theory analysis, we show that the density structure can be unstable to nonaxisymmetric modes. We find that, for the magnetic field profiles we have studied, magnetic fields always provide a stabilizing effect to the unstable RVI modes. We discuss the physical mechanism of this stabilizing effect. The threshold and properties of the unstable modes are also discussed in detail. In addition, we present linear stability results for the global magnetorotational instability when the disk is compressible.

  17. Spectrally Efficient OFDMA Lattice Structure via Toroidal Waveforms on the Time-Frequency Plane

    Directory of Open Access Journals (Sweden)

    Sultan Aldirmaz

    2010-01-01

    Full Text Available We investigate the performance of frequency division multiplexed (FDM signals, where multiple orthogonal Hermite-Gaussian carriers are used to increase the bandwidth efficiency. Multiple Hermite-Gaussian functions are modulated by a data set as a multicarrier modulation scheme in a single time-frequency region constituting toroidal waveform in a rectangular OFDMA system. The proposed work outperforms in the sense of bandwidth efficiency compared to the transmission scheme where only single Gaussian pulses are used as the transmission base. We investigate theoretical and simulation results of the proposed methods.

  18. Toroidal Nuclear Matter Distributions of Superheavy Nuclei from Constrained Skyrme-HFB Calculations

    Energy Technology Data Exchange (ETDEWEB)

    Kosior, Amelia [Maria Curie-Sklodowska University, Poland; Staszczak, A. [Maria Curie-Sklodowska University, Poland; Wong, Cheuk-Yin [ORNL

    2017-01-01

    Using the Hartree Fock Bogoliubov (HFB) self-consistent mean-field theory with the SkM* Skyrme energy-density functional, we study nuclear structure properties of even even superheavy nuclei (SHN) of Z = 120 isotopes and N = 184 isotones. The shape of the nucleus along the lowest energy curve as a function of the quadrupole moment Q20 makes a sud- den transition from the oblate spheroids (biconcave discs) to the toroidal shapes, in the region of large oblate quadrupole moments.

  19. Conceptual studies of toroidal field magnets for the tokamak experimental power reactor. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Buncher, B.R.; Chi, J.W.H.; Fernandez, R.

    1976-10-26

    This report documents the principal results of a Conceptual Design Study for the Superconducting Toroidal Field System for a Tokamak Experimental Power Reactor. Two concepts are described for peak operating fields at the windings of 8 tesla, and 12 tesla, respectively. The design and manufacturing considerations are treated in sufficient detail that cost and schedule estimates could be developed. Major uncertainties in the design are identified and their potential impact discussed, along with recommendations for the necessary research and development programs to minimize these uncertainties. The minimum dimensions of a sub-size test coil for experimental qualification of the full size design are developed and a test program is recommended.

  20. Effects of energetic particles on zonal flow generation by toroidal Alfven eigenmode

    CERN Document Server

    Qiu, Zhiyong; Zonca, Fulvio

    2016-01-01

    Generation of zonal ow (ZF) by energetic particle (EP) driven toroidal Alfven eigenmode (TAE) is investigated using nonlinear gyrokinetic theory. It is found that, nonlinear resonant EP contri- bution dominates over the usual Reynolds and Maxwell stresses due to thermal plasma nonlinear response. ZF can be forced driven in the linear growth stage of TAE, with the growth rate being twice the TAE growth rate. The ZF generation mechanism is shown to be related to polarization induced by resonant EP nonlinearity. The generated ZF has both the usual meso-scale and micro- scale radial structures. Possible consequences of this forced driven ZF on the nonlinear dynamics of TAE are also discussed.

  1. Frequency Spectrum of Fluctuations Near a Rational Surface in a Toroidal Heliac

    Science.gov (United States)

    Zama, Tatsuya; Kitajima, Sumio; Takayama, Masakazu; Takeuchi, Nobunao; Watanabe, Hiroshige

    1993-03-01

    Density and space potential fluctuations have been studied in electron cyclotron resonance heating (ECRH) plasma of a helical axis stellarator TU Heliac using Langmuir probe techniques. These fluctuations are coherent and global, which can be explained by a drift instability model in cylindrical geometry. A particular fluctuation mode vanishes inside a rational surface. The ratio of this mode, n/m, corresponds to the rotational transform \\includegraphics{dummy.eps} of this rational surface, (m, n: poloidal, toroidal fluctuation modes, respectively). This phenomenon near the rational surface can also be explained by a drift instability theory.

  2. Finite-orbit-width effects on the geodesic acoustic mode in the toroidally rotating tokamak plasma

    CERN Document Server

    Ren, Haijun

    2016-01-01

    The Landau damping of geodesic acoustic mode (GAM) in a torodial rotating tokamak plasma is analytically investigated by taking into account the finite-orbit-width (FOW) resonance effect to the 3rd order. The analytical result is shown to agree well with the numerical solution. The dependence of the damping rate on the toroidal Mach number $M$ relies on $k_r \\rho_i$. For sufficiently small $k_r \\rho_i$, the damping rate monotonically decreases with $M$. For relatively large $k_r \\rho_i$, the damping rate increases with $M$ until approaching the maximum and then decreases with $M$.

  3. Toroidal silicon polarization analyzer for resonant inelastic x-ray scattering.

    Science.gov (United States)

    Gao, Xuan; Casa, Diego; Kim, Jungho; Gog, Thomas; Li, Chengyang; Burns, Clement

    2016-08-01

    Resonant Inelastic X-ray Scattering (RIXS) is a powerful probe for studying electronic excitations in materials. Standard high energy RIXS measurements do not measure the polarization of the scattered x-rays, which is unfortunate since it carries information about the nature and symmetry of the excitations involved in the scattering process. Here we report the fabrication of thin Si-based polarization analyzers with a double-concave toroidal surface, useful for L-edge RIXS studies in heavier atoms such as the 5-d transition metals.

  4. Poloidal flow and toroidal particle ring formation in a sessile drop driven by megahertz order vibration.

    Science.gov (United States)

    Rezk, Amgad R; Yeo, Leslie Y; Friend, James R

    2014-09-23

    Poloidal flow is curiously formed in a microliter sessile water drop over 157-225 MHz because of acoustic streaming from three-dimensional standing Lamb waves in a lithium niobate substrate. The flow possesses radial symmetry with downwelling at the center and upwelling around the periphery of the drop. Outside this frequency range, the attenuation occurs over a length scale incompatible with the drop size and the poloidal flow vanishes. Remarkably, shear-induced migration was found to drive toroidal particle ring formation with diameters inversely proportional to the frequency of the acoustic irradiation.

  5. Transport of Parallel Momentum by Toroidal Ion Temperature Gradient Instability near Marginality

    Energy Technology Data Exchange (ETDEWEB)

    E.S. Yoon and T.S. Hahm

    2009-10-20

    The turbulent angular momentum flux carried by ions resonant with toroidal ion temperature gradient(ITG) instability is calculated via quasilinear calculation using the phase-space conserving gyrokinetic equation in the laboratory frame. The results near ITG marginality indicate that the inward turbulent equipartition (TEP) momentum pinch [Hahm T.S. et al 2007 Phys. Plasmas 14 072302] remains as the most robust part of pinch. In addition, ion temperature gradient driven momentum flux is inward for typical parameters, while density gradient driven momentum flux is outward as in the previous kinetic result in slab geometry [Diamond P.H. et al 2008 Phys. Plasmas 15 012303].

  6. Using a priori knowledge for developing bolometric tomography in toroidal devices

    Science.gov (United States)

    Sano, Ryuichi; Peterson, Byron J.; Mukai, Kiyofumi; Teranishi, Masaru; Iwama, Naofumi; Kobayashi, Masahiro

    2016-11-01

    In tomographic imaging of magnetically confined toroidal plasmas, a countermeasure against missing observation has been studied in terms of the adoption of prior information based on modelled plasma profiles. The Tikhonov regularization for image reconstruction is extended by the use of the Euclidean distance. A procedure of model fitting is designed in order to adaptively generate the reference image. The new method is tested on a typical example of ill-conditioned tomography, that is, the three-dimensional imaging-bolometer tomography in the large helical device. It has been found that the new method is useful for diminishing artifacts and thus for better recognizing the radiation structure of plasma.

  7. Stabilisation of ballooning modes in torsatrons with an externally applied toroidal current

    Energy Technology Data Exchange (ETDEWEB)

    Cooper, W.A. [Ecole Polytechnique Federale, Lausanne (Switzerland). Centre de Recherche en Physique des Plasma (CRPP)

    1996-09-01

    It has been found that ideal ballooning modes can impose very restrictive volume average {beta} limits in torsatrons much below the typical values close to 5% that are required to be economically realisable as reactor systems and it has been shown that externally applied toroidal currents that are peaked can destabilise the Mercier criterion in this type of configuration. We will show here that if the applied currents are hollow, they can stabilise the ballooning modes without triggering Mercier instabilities and as a result raise the limiting {beta}* from 2% to 5%. (author) 3 figs., 10 refs.

  8. Static envelope patterns in composite resonances generated by level crossing in optical toroidal microcavities.

    Science.gov (United States)

    Carmon, Tal; Schwefel, Harald G L; Yang, Lan; Oxborrow, Mark; Stone, A Douglas; Vahala, Kerry J

    2008-03-14

    We study level crossing in the optical whispering-gallery (WG) modes by using toroidal microcavities. Experimentally, we image the stationary envelope patterns of the composite optical modes that arise when WG modes of different wavelengths coincide in frequency. Numerically, we calculate crossings of levels that correspond with the observed degenerate modes, where our method takes into account the not perfectly transverse nature of their field polarizations. In addition, we analyze anticrossing with a large avoidance gap between modes of the same azimuthal number.

  9. External kinks in plasmas with helical boundary deformation and net toroidal current

    Energy Technology Data Exchange (ETDEWEB)

    Ardelea, A. [Ecole Polytechnique Federale, Lausanne (Switzerland). Centre de Recherche en Physique des Plasma (CRPP)

    1997-11-01

    The investigation of the global ideal magnetohydrodynamic (MHD) stability of plasmas with helical boundary shape and nonvanishing toroidal plasma current constitutes the principal aim of this work. Global external modes with small values of m,n (typically n = 1,2,3 and m = n+1) are studied, where m and n are the poloidal and toroidal mode numbers, respectively. The first and main part of the work concentrates on fixed boundary equilibria generated by systematically varying parameters such as the type and the magnitude of the boundary deformation, the number of equilibrium field periods N{sub per}, the aspect ratio, the toroidal current density profile, {beta} and the pressure profile. Due to the periodicity of the equilibrium, couplings between Fourier perturbation components with different toroidal mode numbers n occur and lead to the apparition of families of modes. The study of a particular (m,n) mode has to take into account all (m{sub l}, n{sub l}) perturbation components with n{sub 1} belonging to the same family as n. The stability analysis is carried out in the parameter region where the inverse rotational transform (the safety factor in the traditional tokamak notation) q{<=}2.0 and {beta}{<=}2%. A particular property of the configurations investigated is that equilibrium Fourier components (m{sub e}, N{sub per}n{sub e}) which are involved in the couplings between the (m,n) mode studied and the (m{sub k},n{sub k}) perturbation components with m{sub k}>n{sub k}>n that exhibit resonances in the q>1 region are very small. As a consequence, the contributions of the (m,n)x(m{sub k},n{sub k}) couplings to the potential energy are very weak. It is shown that a helical boundary deformation can stabilize the n=1,2,3 external modes; if {delta} is a measure of the plasma boundary deformation, then windows of stability [{delta}{sub min}, {delta}{sub max}] may exist for a large variety of equilibrium parameters. (author) figs., tabs., 44 refs.

  10. Zonal flow driven by energetic particle during magneto-hydro-dynamic burst in a toroidal plasma

    Science.gov (United States)

    Ohshima, S.; Fujisawa, A.; Shimizu, A.; Nakano, H.; Iguchi, H.; Yoshimura, Y.; Nagaoka, K.; Minami, T.; Isobe, M.; Nishimura, S.; Suzuki, C.; Akiyama, T.; Takahashi, C.; Takeuchi, M.; Ito, T.; Watari, T.; Kumazawa, R.; Itoh, S.-I.; Itoh, K.; Matsuoka, K.; Okamura, S.

    2007-11-01

    The internal structural measurements of electric field and density using twin heavy ion beam probes have been performed to elucidate the nonlinear evolution of the magneto-hydro-dynamic (MHD) bursty phenomenon driven by the interaction with high-energy particles in a toroidal plasma. The results have given the finest observation of the internal structure of plasma quantities, such as electric field, density and magnetic field distortion, which nonlinearly develop during the MHD phenomenon. In particular, the finding of a new kind of oscillating zonal flow driven by interaction between energetic particles and MHD modes should be emphasized for burning state plasmas.

  11. Controlling Confinement with Induced Toroidal Current in the Flexible Heliac TJ-II

    Energy Technology Data Exchange (ETDEWEB)

    Romero, J. A.; Lopez-Bruna, D.; Lopez-Fraguas, A.; Ascasibar, E.; TJ-II Team

    2002-07-01

    A method to control plasma particle an energy confinement in the TJ-II Heliac devices is reported A small toroidal current is induced in the plasma with the aid of a 0.2 Wb air core transformer. Plasma particle and energy confinement improve (degrade) with negative (positive) plasma current. For typical TJ-II discharges plasma density and temperature broaden considerably when plasma current is sufficiently negative, accounting for a 40% increase in stored energy. The experimental results agree qualitatively with the paradigm of instability growth rate modifications with magnetic shear. (Author) 18 refs.

  12. A Toroidally Symmetric Plasma Simulation code for design of position and shape control on tokamak plasmas

    Energy Technology Data Exchange (ETDEWEB)

    Takase, Haruhiko [Japan Atomic Energy Research Inst., Naka, Ibaraki (Japan). Naka Fusion Research Establishment; Senda, Ikuo

    1999-04-01

    A Toroidally Symmetric Plasma Simulation (TSPS) code has been developed for investigating the position and shape control on tokamak plasmas. The analyses of three-dimensional eddy currents on the conducting components around the plasma and the two-dimensional magneto-hydrodynamic (MHD) equilibrium are taken into account in this code. The code can analyze the plasma position and shape control during the minor disruption in which the deformation of plasma is not negligible. Using the ITER (International Thermonuclear Experimental Reactor) parameters, some examples of calculations are shown in this paper. (author)

  13. The attenuation of Love waves and toroidal oscillations of the earth.

    Science.gov (United States)

    Jackson, D. D.

    1971-01-01

    An attempt has been made to invert a large set of attenuation data for Love waves and toroidal oscillations in the earth, using a recent method by Backus and Gilbert. The difficulty in finding an acceptable model of internal friction which explains the data, under the assumption that the internal friction is independent of frequency, casts doubt on the validity of this assumption. A frequency-dependent model of internal friction is presented which is in good agreement with the seismic data and with recent experimental measurements of attenuation in rocks.

  14. Perfluorocarbon inhibits lipopolysaccharide-induced macrophage inflammatory protein-2 expression and activation of ATF-2 and c-Jun in A549 pulmonary epithelial cells.

    Science.gov (United States)

    Hu, Y; Li, C S; Li, Y Q; Liang, Y; Cao, L; Chen, L A

    2016-04-30

    The signaling pathway that mediates the anti-inflammatory effects of perfluorocarbon (PFC) in alveolar epithelial cells treated with lipopolysaccharide (LPS) remains unclear. To evaluate the role of macrophage-inflammatory protein-2 (MIP-2), four A549 treatment groups were utilized: (1) untreated control, (2) 10 μg/mL of LPS, (3) 10 μg/mL of LPS+30% PFC and (4) 30% PFC. MIP-2 mRNA expression was determined by qPCR and ELISA. Mitogen-activated protein kinase (MAPK) activation was determined by Western blot analysis, and MIP-2 expression was determined by qPCR following treatment with MAPK inhibitors. PFC suppressed LPS-induced MIP-2 mRNA levels (P≤0.035) and MIP-2 secretion (P≤0.046). LPS induced ATF-2 and c-Jun phosphorylation, which was suppressed by PFC. Finally, inhibitors of ERK, JNK, and p38 suppressed LPS-induced MIP-2 mRNA expression. Thus, PFC inhibits LPS-induced MIP-2 expression and ATF-2 and c-Jun phosphorylation. To fully explore the therapeutic potential of PFC for acute lung injury (ALI), in vivo analyses are required to confirm these effects.

  15. Influence of the valine zipper region on the structure and aggregation of the basic leucine zipper (bZIP) domain of activating transcription factor 5 (ATF5).

    Science.gov (United States)

    Ciaccio, Natalie A; Reynolds, T Steele; Middaugh, C Russell; Laurence, Jennifer S

    2012-11-01

    Protein aggregation is a major problem for biopharmaceuticals. While the control of aggregation is critically important for the future of protein pharmaceuticals, mechanisms of aggregate assembly, particularly the role that structure plays, are still poorly understood. Increasing evidence indicates that partially folded intermediates critically influence the aggregation pathway. We have previously reported the use of the basic leucine zipper (bZIP) domain of activating transcription factor 5 (ATF5) as a partially folded model system to investigate protein aggregation. This domain contains three regions with differing structural propensity: a N-terminal polybasic region, a central helical leucine zipper region, and a C-terminal extended valine zipper region. Additionally, a centrally positioned cysteine residue readily forms an intermolecular disulfide bond that reduces aggregation. Computational analysis of ATF5 predicts that the valine zipper region facilitates self-association. Here we test this hypothesis using a truncated mutant lacking the C-terminal valine zipper region. We compare the structure and aggregation of this mutant to the wild-type (WT) form under both reducing and nonreducing conditions. Our data indicate that removal of this region results in a loss of α-helical structure in the leucine zipper and a change in the mechanism of self-association. The mutant form displays increased association at low temperature but improved resistance to thermally induced aggregation.

  16. Microarray hybridization analysis of light-dependent gene expression in Penicillium chrysogenum identifies bZIP transcription factor PcAtfA.

    Science.gov (United States)

    Wolfers, Simon; Kamerewerd, Jens; Nowrousian, Minou; Sigl, Claudia; Zadra, Ivo; Kürnsteiner, Hubert; Kück, Ulrich; Bloemendal, Sandra

    2015-04-01

    The fungal velvet complex is a light-dependent master regulator of secondary metabolism and development in the major penicillin producer, Penicillium chrysogenum. However, the light-dependent mechanism is unclear. To identify velvet-dependent transcriptional regulators that show light-regulated expression, we performed microarray hybridizations with RNA isolated from P. chrysogenum ΔPcku70 cultures grown under 13 different long-term, light-dependent growth conditions. We compared these expression data to data from two velvet complex deletion mutants; one lacked a subunit of the velvet complex (ΔPcvelA), and the other lacked a velvet-associated protein (ΔPclaeA). We sought to identify genes that were up-regulated in light, but down-regulated in ΔPcvelA and ΔPclaeA. We identified 148 co-regulated genes that displayed this regulatory pattern. In silico analyses of the co-regulated genes identified six proteins with fungal-specific transcription factor domains. Among these, we selected the bZIP transcription factor, PcAtfA, for functional characterization in deletion and complementation strains. Our data clearly indicates that PcAtfA governs spore germination. This comparative analysis of different microarray hybridization data sets provided results that may be useful for identifying genes for future functional analyses.

  17. Recent Advancements in Microwave Imaging Plasma Diagnostics

    Energy Technology Data Exchange (ETDEWEB)

    H. Park; C.C. Chang; B.H. Deng; C.W. Domier; A.J.H. Donni; K. Kawahata; C. Liang; X.P. Liang; H.J. Lu; N.C. Luhmann, Jr.; A. Mase; H. Matsuura; E. Mazzucato; A. Miura; K. Mizuno; T. Munsat; K. and Y. Nagayama; M.J. van de Pol; J. Wang; Z.G. Xia; W-K. Zhang

    2002-03-26

    Significant advances in microwave and millimeter wave technology over the past decade have enabled the development of a new generation of imaging diagnostics for current and envisioned magnetic fusion devices. Prominent among these are revolutionary microwave electron cyclotron emission imaging (ECEI), microwave phase imaging interferometers, imaging microwave scattering and microwave imaging reflectometer (MIR) systems for imaging electron temperature and electron density fluctuations (both turbulent and coherent) and profiles (including transport barriers) on toroidal devices such as tokamaks, spherical tori, and stellarators. The diagnostic technology is reviewed, and typical diagnostic systems are analyzed. Representative experimental results obtained with these novel diagnostic systems are also presented.

  18. Oscillations of magnetic stars: II. Axisymmetric toroidal and non-axisymmetric shear Alfven modes in a spherical shell

    CERN Document Server

    Reese, D; Rieutord, M

    2004-01-01

    We carry out numerical and mathematical investigations of shear Alfven waves inside of a spherical shell filled with an incompressible conducting fluid, and bathed in a strong dipolar magnetic field. We focus on axisymmetric toroidal and non-axisymmetric modes, in continuation of a previous work by Rincon & Rieutord (2003). Analytical expressions are obtained for toroidal eigenmodes and their corresponding frequencies at low diffusivities. These oscillations behave like magnetic shear layers, in which the magnetic poles play a key role, and hence become singular when diffusivities vanish. It is also demonstrated that non-axisymmetric modes are split into two categories, namely poloidal or toroidal types, following similar asymptotic behaviours as their axisymmetric counterparts when the diffusivities become arbitrarily small.

  19. On the toroidal current density flowing across a poloidal-magnetic-field null in an axisymmetric plasma

    Science.gov (United States)

    Rodrigues, Paulo; Bizarro, João P. S.

    2013-04-01

    The axisymmetry condition and two of Maxwell's equations are used to show that, in general, there are no nested magnetic surfaces around a poloidal-magnetic-field null for a sufficiently small value of the toroidal current density flowing there. Hence, the toroidal current density at the axis of a magnetic configuration with extreme shear reversal cannot continuously approach zero unless nested surfaces are first broken or particular values are assigned to boundary conditions and other plasma parameters. The threshold of the toroidal current-density at which the topology changes is shown to be set by such parameters, and some examples of the predicted topology transition are presented using analytical solutions of the Grad-Shafranov equation.

  20. On the toroidal current density flowing across a poloidal-magnetic-field null in an axisymmetric plasma

    Energy Technology Data Exchange (ETDEWEB)

    Rodrigues, Paulo; Bizarro, Joao P. S. [Associacao Euratom-IST, Instituto de Plasmas e Fusao Nuclear, Instituto Superior Tecnico, Universidade Tecnica de Lisboa, 1049-001 Lisboa (Portugal)

    2013-04-15

    The axisymmetry condition and two of Maxwell's equations are used to show that, in general, there are no nested magnetic surfaces around a poloidal-magnetic-field null for a sufficiently small value of the toroidal current density flowing there. Hence, the toroidal current density at the axis of a magnetic configuration with extreme shear reversal cannot continuously approach zero unless nested surfaces are first broken or particular values are assigned to boundary conditions and other plasma parameters. The threshold of the toroidal current-density at which the topology changes is shown to be set by such parameters, and some examples of the predicted topology transition are presented using analytical solutions of the Grad-Shafranov equation.

  1. The optical designing method and the concentrating performance analysis for a toroidal heliostat with spinning-elevation sun tracking

    Energy Technology Data Exchange (ETDEWEB)

    Guo, Minghuan [Himin Solar Energy Group, Dezhou (China); CAS, Inst. of Electrical Engineering, Beijing (China); Lu, Zhenwu [CAS, Changchun Inst. of Optics Fine Mechanics and Physics, Changchun (China). State Key Lab. of Applied Optics; Wang, Zhifeng [Himin Solar Energy Group, Dezhou (China)

    2008-07-01

    A practical optical designing method for and some optical simulation results of a toroidal surface heliostat with the two axis spinning-elevation sun tracking are presented in this paper, which will be used as a concentrator for a hydrogen generation system. As a prototype, this heliostat has a compound toroidal surface, which is composed of the 16 same toroidal mirror facets of 1 meter width and 1 meter height with the focal length 7.4689 meters, and the design concentration power of the heliostat is 6 kilowatts. The sampling ray-tracing method including the solar disk effect is introduced and used to analyze the optical performance of the heliostat. The optical errors of the heliostat and the attenuation of reflected solar irradiance in the air have not been taken into account yet. (orig.)

  2. Armament Technology Facility (ATF)

    Data.gov (United States)

    Federal Laboratory Consortium — The Armament Technology Facility is a 52,000 square foot, secure and environmentally-safe, integrated small arms and cannon caliber design and evaluation facility....

  3. Generation of microstripe cylindrical and toroidal mirrors by localized laser evaporation of fused silica.

    Science.gov (United States)

    Wlodarczyk, Krystian L; Thomson, Ian J; Baker, Howard J; Hall, Denis R

    2012-09-10

    We report a new technique for the rapid fabrication of microstripe cylindrical and toroidal mirrors with a high ratio (>10) of the two principal radii of curvature (RoC(1)/RoC(2)), and demonstrate their effectiveness as mode-selecting resonator mirrors for high-power planar waveguide lasers. In this process, the larger radius of curvature (RoC(1)) is determined by the planar or cylindrical shape of the fused silica substrate selected for laser processing, whilst the other (RoC(2)) is produced by controlled CO(2) laser-induced vaporization of the glass. The narrow stripe mirror aperture is achieved by applying a set of partially overlapped laser scans, with the incident laser power, the number of laser scans, and their spacing being used to control the curvature produced by laser evaporation. In this work, a 1 mm diameter laser spot is used to produce grooves of cylindrical/toroidal shape with 240 μm width and 16 mm length. After high reflectance coating, these grooves are found to provide excellent mode selectivity as resonator mirrors for a 150 μm core Yb:YAG planar waveguide laser, producing high brightness output at more than 300 W. The results show clearly that the laser-generated microstripe mirrors can improve the optical performance of high-power planar waveguide lasers when applied in a low-loss mode-selective resonator configuration.

  4. A Simulation Model for the Toroidal Ion Temperature Gradient Instability with Fully Kinetic Ions

    Science.gov (United States)

    Sturdevant, Benjamin; Parker, Scott; Chen, Yang

    2016-10-01

    A simulation model for the toroidal ITG mode in which the ions follow the primitive Lorentz force equations of motion is presented. Such a model can provide an important validation tool or replacement for gyrokinetic ion models in applications where higher order terms may be important. A number of multiple-scale simulation techniques are employed in this work, based on the previous success in slab geometry with an implicit orbit averaged and sub-cycled δf model. For the toroidal geometry model, we have derived a particle integration scheme based on variational principles, which is demonstrated to produce stable and accurate ion trajectories on long time scales. Orbit averaging and sub-cycling will be implemented with the variational integration scheme. The inclusion of equilibrium gradients in the fully kinetic δf formulation is achieved through the use of a guiding center coordinate transformation of the weight equation. Simulation results for the fully kinetic ion model will be presented for the cyclone base case and comparisons will be made with gyrokinetic ion models.

  5. The common cryogenic test facility for the ATLAS barrel and end-cap toroid magnets

    CERN Document Server

    Delruelle, N; Junker, S; Passardi, Giorgio; Pengo, R; Pirotte, O

    2004-01-01

    The large ATLAS toroidal superconducting magnet made of the Barrel and two End-Caps needs extensive testing at the surface of the individual components prior to their final assembly into the underground cavern of LHC. A cryogenic test facility specifically designed for cooling sequentially the eight coils making the Barrel Toroid (BT) has been fully commissioned and is now ready for final acceptance of these magnets. This facility, originally designed for testing individually the 46 tons BT coils, will be upgraded to allow the acceptance tests of the two End-Caps, each of them having 160 tons cold mass. The integrated system mainly comprises a 1.2 kW@4.5 K refrigerator, a 10 kW liquid-nitrogen precooler, two cryostats housing liquid helium centrifugal pumps of respectively 80 g/s and 600 g/s nominal flow and specific instrumentation to measure the thermal performances of the magnets. This paper describes the overall facility with particular emphasis to the cryogenic features adopted to match the specific requ...

  6. The Common Cryogenic Test Facility for the Atlas Barrel and End-Cap Toroid Magnet

    CERN Document Server

    Delruelle, N; Junker, S; Passardi, Giorgio; Pengo, R; Pirotte, O

    2004-01-01

    The large ATLAS toroidal superconducting magnet made of the Barrel and two End-Caps needs extensive testing at the surface of the individual components prior to their final assembly into the underground cavern of LHC. A cryogenic test facility specifically designed for cooling sequentially the eight coils making the Barrel Toroid (BT) has been fully commissioned and is now ready for final acceptance of these magnets. This facility, originally designed for testing individually the 46 tons BT coils, will be upgraded to allow the acceptance tests of the two End-Caps, each of them having a 160 tons cold mass. The integrated system mainly comprises a 1.2 kW@4.5 K refrigerator, a 10 kW liquid-nitrogen precooler, two cryostats housing liquid helium centrifugal pumps of respectively 80 g/s and 600 g/s nominal flow and specific instrumentation to measure the thermal performances of the magnets. This paper describes the overall facility with particular emphasis to the cryogenic features adopted to match the specific re...

  7. The effect of toroidal field on the rotating magnetic field current drive in rotamak plasmas

    Institute of Scientific and Technical Information of China (English)

    Zhong Fang-Chuan; Huang Tian-Sen; Petrov Yuri

    2007-01-01

    A rotamak is one kind of compact spherically shaped magnetic-confinement device. In a rotamak the plasma current is driven by means of rotating magnetic field (RMF). The driven current can reverse the original equilibrium field and generate a field-reversed-configuration. In a conventional rotamak, a toroidal field (TF) is not necessary for the RMF to drive plasma current, but it was found that the present of an additional TF can influence the RMF current drive. In this paper the effect of TF on the RMF current drive in a rotamak are investigated in some detail.The experimental results show that addition of TF increases the RMF driven current greatly and enhances the RMF penetration dramatically. Without TF, the RMF can only penetrate into plasma in the edge region. When a TF is added, the RMF can reach almost the whole plasma region. This is an optimal strength of toroidal magnetic field for getting maximum plasma current when Bv and radio frequency generator power are fixed. Besides driving current,the RMF generates high harmonic fields in rotamak plasma. The effect of TF on the harmonic field spectra are also reported.

  8. The CERN Cryogenic Test Facility for the Atlas Barrel Toroid Magnets

    CERN Document Server

    Haug, F; Delruelle, N; Orlic, J P; Passardi, Giorgio; Tischhauser, Johann

    1999-01-01

    The superconducting magnet system of the ATLAS detector will consist of a central solenoid, two end-cap toroidal magnets (ECT) and the barrel toroid magnet (BT) made of eight coils symmetrically placed around the central axis of the detector. The magnets will be tested individually in a 5000 m2 experimental area prior to their final installation at an underground cavern of the LHC Collider. For the BT magnets, a dedicated cryogenic test facility has been designed which is currently under the construction and commissioning phase. A liquid nitrogen pre-cooling unit and a 1200 W@4.5K refrigerator will allow flexible operating conditions via a rather complex distribution and transfer line system. Flow of two-phase helium for cooling the coils is provided by centrifugal pumps immersed in a saturated liquid helium bath. The integration of the pumps in an existing cryostat required the adoption of novel mechanical solutions. Tests conducted permitted the validation of the technical design of the cryostat and its ins...

  9. Modeling non-saturated ferrite-based devices: Application to twin toroid ferrite phase shifters

    Science.gov (United States)

    Le Gouellec, A.; Vérissimo, G.; Laur, V.; Queffelec, P.; Albert, I.; Girard, T.

    2016-08-01

    This article describes a new set of tools developed to improve the conception and modeling of non-saturated ferrite-based devices such as twin toroid phase shifters. These new simulation tools benefit from a generalized permeability tensor model able to describe the permeability tensor of a ferrite sample whatever its magnetization state. This model is coupled to a homemade 3D multi-scale magnetostatic analysis program, which describes the evolution of the magnetization through the definition of a hysteresis loop in every mesh cell. These computed spectra are then integrated into 3D electromagnetic simulation software that retains the spatial variations of the ferrite properties by using freshly developed macro programming functions. This new approach allows the designers to accurately model complex ferrite devices such as twin toroid phase shifters. In particular, we demonstrated a good agreement between simulated and measured phase shifts as a function of applied current values with a predicted maximum phase shift of 0.96 times the measured value.

  10. Study of plasma equilibrium in toroidal fusion devices using mesh-free numerical calculation method

    Science.gov (United States)

    Rasouli, C.; Abbasi Davani, F.; Rokrok, B.

    2016-08-01

    Plasma confinement using external magnetic field is one of the successful ways leading to the controlled nuclear fusion. Development and validation of the solution process for plasma equilibrium in the experimental toroidal fusion devices is the main subject of this work. Solution of the nonlinear 2D stationary problem as posed by the Grad-Shafranov equation gives quantitative information about plasma equilibrium inside the vacuum chamber of hot fusion devices. This study suggests solving plasma equilibrium equation which is essential in toroidal nuclear fusion devices, using a mesh-free method in a condition that the plasma boundary is unknown. The Grad-Shafranov equation has been solved numerically by the point interpolation collocation mesh-free method. Important features of this approach include truly mesh free, simple mathematical relationships between points and acceptable precision in comparison with the parametric results. The calculation process has been done by using the regular and irregular nodal distribution and support domains with different points. The relative error between numerical and analytical solution is discussed for several test examples such as small size Damavand tokamak, ITER-like equilibrium, NSTX-like equilibrium, and typical Spheromak.

  11. Energetic particle driven geodesic acoustic mode in a toroidally rotating tokamak plasma

    Science.gov (United States)

    Ren, Haijun

    2017-01-01

    Energetic particle (EP) driven geodesic acoustic modes (EGAMs) in toroidally rotating tokamak plasmas are analytically investigated using the hybrid kinetic-fluid model and gyrokinetic equations. By ignoring high-order terms and ion Landau damping, the kinetic dispersion relation is reduced to the hybrid one in the large safety factor limit. There is one high-frequency branch with a frequency larger than {ωt0} , the transit frequency of EPs with initial energy, which is always stable. Two low-frequency solutions with a frequency smaller than {ωt0} are complex conjugates in the hybrid limit. In the presence of ion Landau damping, the growth rate of the unstable branch is decreased and the damping rate of the damped branch is increased. The toroidal Mach number is shown to increase {{ Ω }\\text{r}} , the normalized real frequency of both branches. Although not affecting the instability critical condition, the Mach number decreases the growth rate when {{ Ω }\\text{r}} is larger than a critical value Ω \\text{r}\\text{cri} and enlarges the growth rate when {{ Ω }\\text{r}}Landau damping effect is negligible for large M. But the discrepancy between the kinetic dispersion relation and the hybrid one becomes ignorable only for q≳ 7 .

  12. Coherence Imaging Measurements of Impurity Flow in the Compact Toroidal Hybrid Experiment

    Science.gov (United States)

    Ennis, D. A.; Hartwell, G. J.; Johnson, C. A.; Maurer, D. A.; Allen, S. L.; Meyer, W. H.; Samuell, C. M.

    2016-10-01

    Measurements of impurity ion emissivity and velocity in the Compact Toroidal Hybrid (CTH) experiment are achieved with a new optical coherence imaging diagnostic. The Coherence Imaging Spectroscopy (CIS) technique measures the spectral coherence of an emission line with an imaging interferometer of fixed delay. CIS has a number of advantages when compared to dispersive Doppler spectroscopy, including higher throughput and the capability to provide 2D spectral images, making it ideal for investigating the non-axisymmetric geometry of CTH plasmas. Furthermore, detailed measurements of the ion flow structure provided by CIS combined with predictive computational models could also provide spatially resolved images of complex flow structures, such as those associated with an island divertor. First CIS measurements of CTH plasmas reveal strong signals for C III (465 nm), He II (468 nm) and C II (513 nm) emission. Preliminary analysis of C III interferograms indicate a net toroidal flow on the order of 10 km/s during the time of peak current. Bench tests using Zn and Cd light sources reveal that the temperature of the instrument must be actively controlled to within 0.01°C to limit phase drift of the interferometer resulting in artificially measured flow. Results from this diagnostic will aid in characterizing the ion flow in planned island divertor and MHD mode-locking experiments. Work supported by USDoE Grant DE-FG02-00ER54610.

  13. Experiments with low energy ion beam transport into toroidal magnetic fields

    CERN Document Server

    Joshi, N; Meusel, O; Ratzinger, U

    2016-01-01

    The stellarator-type storage ring for accumulation of multi- Ampere proton and ion beams with energies in the range of $100~AkeV$ to $1~AMeV$ is designed at Frankfurt university. The main idea for beam confinement with high transversal momentum acceptance was presented in EPAC2006. This ring is typically suited for experiments in plasma physics and nuclear astrophysics. The accumulator ring with a closed longitudinal magnetic field is foreseen with a strength up to $6-8~T$. The experiments with two room temperature 30 degree toroids are needed. The beam transport experiments in toroidal magnetic fields were first described in EPAC2008 within the framework of a proposed low energy ion storage ring. The test setup aims on developing a ring injection system with two beam lines representing the main beam line and the injection line. The primary beam line for the experiments was installed and successfully commissioned in 2009. A special diagnostics probe for \\textit{"in situ"} ion beam detection was installed.This...

  14. The CERN cryogenic test facility for the ATLAS barrel toroid magnets

    CERN Document Server

    Haug, F; Delruelle, N; Orlic, J P; Passardi, Giorgio; Tischhauser, Johann

    2000-01-01

    The superconducting magnet system of the ATLAS detector will consist of a central solenoid, two end-cap toroidal magnets (ECT) and the barrel toroid magnet (BT) made of eight coils symmetrically placed around the central axis of the detector. The magnets will be tested individually in a 5000 m/sup 2/ experimental area prior to their final installation at an underground cavern of the LHC Collider. For the BT magnets, a dedicated cryogenic test facility has been designed which is currently under the construction and commissioning phase. A liquid nitrogen pre-cooling unit and a 1200 W@4.5K refrigerator will allow flexible operating conditions via a rather complex distribution and transfer line system. Flow of two-phase helium for cooling the coils is provided by centrifugal pumps immersed in a saturated liquid helium bath. The integration of the pumps in an existing cryostat required the adoption of novel mechanical solutions. Tests conducted permitted the validation of the technical design of the cryostat and i...

  15. The upgraded JET toroidal Alfvén eigenmode diagnostic system

    Science.gov (United States)

    Puglia, P.; Pires de Sa, W.; Blanchard, P.; Dorling, S.; Dowson, S.; Fasoli, A.; Figueiredo, J.; Galvão, R.; Graham, M.; Jones, G.; Perez von Thun, C.; Porkolab, M.; Ruchko, L.; Testa, D.; Woskov, P.; Albarracin-Manrique, M. A.; Contributors, JET

    2016-11-01

    The main characteristics of toroidal Alfvén eigenmodes (TAEs) have been successfully investigated in JET (Joint European Torus) using the scheme of sweeping-frequency external excitation with tracking of the synchronously-detected resonances. However, due to technical limitations, only modes with low values of the toroidal mode number n≤slant 7 could be effectively excited and unambiguously identified by the Alfvén Eigenmode Active Diagnostic (AEAD) system. This represents a serious restriction because theoretical models indicate that medium-n Alfvén eigenmodes (AEs) are the most prone to be destabilized by energetic particles in ignited plasmas and, therefore, reliable measurement of their damping rates remains a relevant issue to properly access their effect in ignited plasmas. For this reason, a major upgrade of the AEAD system has been carried out aiming at providing a state-of-the-art excitation and real-time detection system for the planned DT campaign in JET. This required the development of a new type of radio frequency amplifier and filter, not commercially available, and also a control system. In this paper, details of the concepts that are relevant to understand the operation of the new system in the next experimental campaigns are presented, as are the results of numerical simulations to model its performance.

  16. Topology of toroidal helical fields in non-circular cross-sectional tokamaks

    Institute of Scientific and Technical Information of China (English)

    Zha Xue-Jun; Zhu Si-Zheng; Yu Qing-Quan; Wang Yan

    2005-01-01

    The ordinary differential magnetic field line equations are solved numerically; the tokamak magnetic structure is studied on Hefei Tokamak-7 Upgrade (HT-7U) when the equilibrium field with a monotonic q-profile is perturbed by a helical magnetic field. We find that a single mode (m, n) helical perturbation can cause the formation of islands on rational surfaces with q = m/n and q = (m ± 1,±2, ±3,...)/n due to the toroidicity and plasma shape (i.e.elongation and triangularity), while there are many undestroyed magnetic surfaces called Kolmogorov-Arnold-Moser (KAM) barriers on irrational surfaces. The islands on the same rational surface do not have the same size. When the ratio between the perturbing magnetic field (B)r(r) and the toroidal magnetic field amplitude Bφ0 is large enough, the magnetic island chains on different rational surfaces will overlap and chaotic orbits appear in the overlapping area, and the magnetic field becomes stochastic. It is remarkable that the stochastic layer appears first in the plasma edge region.

  17. Theory and simulations of toroidal and rod-like structures in single-molecule DNA condensation.

    Science.gov (United States)

    Cortini, Ruggero; Caré, Bertrand R; Victor, Jean-Marc; Barbi, Maria

    2015-03-14

    DNA condensation by multivalent cations plays a crucial role in genome packaging in viruses and sperm heads, and has been extensively studied using single-molecule experimental methods. In those experiments, the values of the critical condensation forces have been used to estimate the amplitude of the attractive DNA-DNA interactions. Here, to describe these experiments, we developed an analytical model and a rigid body Langevin dynamics assay to investigate the behavior of a polymer with self-interactions, in the presence of a traction force applied at its extremities. We model self-interactions using a pairwise attractive potential, thereby treating the counterions implicitly. The analytical model allows to accurately predict the equilibrium structures of toroidal and rod-like condensed structures, and the dependence of the critical condensation force on the DNA length. We find that the critical condensation force depends strongly on the length of the DNA, and finite-size effects are important for molecules of length up to 10(5)μm. Our Langevin dynamics simulations show that the force-extension behavior of the rod-like structures is very different from the toroidal ones, so that their presence in experiments should be easily detectable. In double-stranded DNA condensation experiments, the signature of the presence of rod-like structures was not unambiguously detected, suggesting that the polyamines used to condense DNA may protect it from bending sharply as needed in the rod-like structures.

  18. The behaviour of the scrape-off layer in JET with toroidal belt limiters

    Energy Technology Data Exchange (ETDEWEB)

    Erents, S.K.; McCracken, G.M.; Tagle, J.A.; Israel, G.; Brinkschulte, H.W.; De Kock, L.

    1989-04-01

    Measurements using a toroidal and poloidal array of 20 Langmuir probes in the JET belt limiter show a toroidal symmetry in edge flux within typically +-15%. A reciprocating probe array has been used to record radial profiles of edge temperature T/sub e/(r), density n/sub e/(r) and floating potential V/sub f/(r) up to 30 mm inside the last closed flux surface (LCFS). A change in sign of dV/sub f/(r)/dr is recorded at the LCFS, together with a clear break in profiles which can be fitted by a single exponential in the limiter shadow. A comparison has been made of the edge data with the belt limiter configuration to that with the discrete limiters. Absolute values of edge parameters are found to be lower, and e-folding lengths steeper, for the belt limiter case. However, the general trends in scaling are very similar to those reported previously. (orig.).

  19. A parametric study on the contact stress of half toroidal continuously variable transmission

    Institute of Scientific and Technical Information of China (English)

    Nabil Abdulla Attia; QIN Datong; SHI Wankai; LI Huaying

    2003-01-01

    The most general contact in mechanical transmission is the elliptical one. In particular, a toroidal continuously variable transmission (CVT) has an elliptical shape in the contact area under the elastohydrodynamic lubrication regime, where the shearing of the fluid subjects to high contact stress and transmits the power. Many parameters affect the contact service performance of the half toroidal CVT, which include the properties of the contacting material (Young's modulus), operating parameters (input torque and maximum traction coefficient) and geometrical parameters (aspect cavity ratio, curvature ratio and half cone angle of the power roller). In this paper, the contacts between the input disk, the power roller and the output disk are formulated using the classical Hertzian contact theory. Based on the formulated equations, different system parameters, which affect the maximum Hertzian stresses, are compared. The comparative results will provide some observations of the relations between the maximum Hertzian stresses and transmission ratios in the form of graphs. These graphs give useful information for designer to know the maximum Hertzian stress during operation in such s ystems.

  20. Fluctuations and symmetry breaking during regeneration of Hydra vulgaris tissue toroids

    CERN Document Server

    Krahe, Michael; Lin, Kao-Nung; Fischer, Julia; Fütterer, Claus

    2012-01-01

    While much is known in single cell mechanics, the mechanics of regeneration of naturally grown tissues and cell assemblies is largely unexplored. We found a symmetry breaking scenario accompanied by shape fluctuations in dissected regenerating Hydra vulgaris tissue tori. A subsequent folding and merging process leads finally to a regenerating spheroid. These phenomena are related to the dynamics of fluorescent beta- and trans-cellular alpha-actin structures. By embedding the tissues in a hydro-gel the fluctuations could be studied over a longer period of time. The power spectrum of the torus-fluctuations shows a non-trivial energy distribution dynamics depending on the gel stiffness. During the transition, many higher modes where found but in the end the 2nd mode wins in most cases. The toroid builds up an uniform alpha-actin ring along the inner edge of the torus. We found this ring in the inner cellular layer to be responsible for the force generation destabilizing the toroid shape. This actin structure is ...