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Sample records for atf advanced toroidal

  1. ATF [Advanced Toroidal Facility] data management

    International Nuclear Information System (INIS)

    Data management for the Advanced Toroidal Facility (ATF), a stellarator located at Oak Ridge National Laboratory (ORNL), is provided by DMG, a locally developed, VAX-based software system. DMG is a data storage and retrieval software system that provides the user interface to ATF raw and analyzed data. Data are described in terms of data models and data types and are organized as signals into files, which are internally documented. The system was designed with user accessibility, software maintainability, and extensibility as primary goals. Extensibility features include compatibility with ATF as it moves from pulsed to steady-state operation and capability for use of the DMG system with experiments other than ATF. DMG is implemented as a run-time library of routines available as a shareable image. General-purpose and specialized data acquisition and analysis applications have been developed using the DMG system. This paper describes the DMG system and the interfaces to it. 4 refs., 2 figs

  2. ATF [Advanced Toroidal Facility]-2 studies

    International Nuclear Information System (INIS)

    Design studies for a low-aspect-ratio, large next-generation stellarator, ATF-II, with high-current-density, high-field, stable NbTi/Cu helical windings are described. The design parameters are an average plasma radius of 0.52 m, a major radius of 2 m, and a field on axis of 4-5 T, with 10 to 15 MW of heating power. Such a device would be comparable in scope to other next-generation stellarators but would have roughly the same aspect ratio as the tokamaks without, however, the need for current drive to sustain steady-state operation. A number of low-aspect-ratio physics issues need to be addressed in the design of ATF-II, primarily compromises between high-beta capability and good confinement properties. A six-field-period Compact Torsatron is chosen as a reference design for ATF-II, and its main features and performance predictions are discussed. An integrated (beta capability and confinement) optimization approach and optimization of superconducting windings are also discussed. 36 refs., 13 figs., 2 tabs

  3. Runaway studies in the ATF [Advanced Toroidal Facility] torsatron

    International Nuclear Information System (INIS)

    Pulsed torsatrons and heliotrons are susceptible to runaway electron formation and confinement resulting from the inherent good containment in the vacuum fields and the high loop voltages during the initiation and termination of the helical and vertical fields (''field ramping''). Because runaway electrons can cause an unacceptable level of hard X rays near the machine, a runaway suppression system was designed and included in the initial operation of the Advanced Toroidal Facility (ATF). The main component of the system is a rotating paddle that is normally left in the vacuum chamber during the field ramps. This device proved to be very effective in reducing the runaway population. Measurements of hard X rays from ATF have shown that the runaways are produced primarily during the field ramping but that usually a small steady-state runaway component is also present during the ''flat-top'' portion of the fields. The paddle is the main source of the hard X rays (thick-target bremsstrahlung), although other objects in the vacuum chamber also serve as targets for the runaways at various times. The maximum X-ray energy found by pulse height analysis is /approximately/12--15 MeV; the mean energy appears to be a few mega-electron-volts. A noticeable forward peaking of the bremsstrahlung from the paddle is evident. The limiters do not appear to be major sources of bremsstrahlung. 17 refs., 14 figs

  4. SAMS: The synchronization and monitoring system for ATF [Advanced Toroidal Facility] data acquisition

    International Nuclear Information System (INIS)

    SAMS performs much of the synchronization of the distributed data acquisition system for the Advanced Toroidal Facility (ATF). SAMS is responsible for propagating shot information and managing te data system directories and logical names. This paper describes how SAMS communicates with other processes, both within the VAX cluster that supports most of the ATF data acquisition and on VAXes that are connected to the cluster via DECnet. 3 refs

  5. Initial high-power testing of the ATF [Advanced Toroidal Facility] ECH [electron cyclotron heating] system

    International Nuclear Information System (INIS)

    The Advanced Toroidal Facility (ATF) is a moderate aspect ratio torsatron that will utilize 53.2 GHz 200 kW Electron Cyclotron Heating (ECH) to produce nearly current-free target plasmas suitable for subsequent heating by strong neutral beam injection. The initial configuration of the ECH system from the gyrotron to ATF consists of an optical arc detector, three bellows, a waveguide mode analyzer, two TiO2 mode absorbers, two 900 miter bends, two waveguide pumpouts, an insulating break, a gate valve, and miscellaneous straight waveguide sections feeding a launcher radiating in the TE02 mode. Later, a focusing Vlasov launcher will be added to beam the ECH power to the saddle point in ATF magnetic geometry for optimum power deposition. The ECH system has several unique features; namely, the entire ECH system is evacuated, the ECH system is broadband, forward power is monitored by a newly developed waveguide mode analyzer, phase correcting miter bends will be employed, and the ECH system will be capable of operating short pulse to cw. Initial high-power tests show that the overall system efficiency is 87%. The waveguide mode analyzer shows that the gyrotron mode output consists of 13% TE01, 82.6% TE02, 2.5% TE03, and 1.9% TE04. 4 refs

  6. A mode-transforming polarization-rotatable launcher for the ATF [Advanced Toroidal Facility] fusion experiment

    International Nuclear Information System (INIS)

    The Advanced Toroidal Facility (ATF) fusion energy experiment at the Oak Ridge National Laboratory (ORNL) requires high-power microwaves for startup and plasma heating. Power from a gyrotron oscillator tube at 53.2 GHz will be used to ionize and heat the plasma by the electron cyclotron heating (ECH) process. The confining magnetic field of the device is either 0.95 or 1.9T. The gyrotron tube generates 200 kW in the TE02 mode, which is transported in an overmoded 6.35-cm-diam circular waveguide to the ATF vacuum vessel. The launcher consists of a mode-converting Vlasov section, which converts the nonpolarized TE02 wave into a linearly polarized narrow beam. The beam reflects off a tiled spherical reflector grating and is focused at the center of the plasma. The polarization can be rotated to optimize the absorption efficiency by rotating the grating in the spherical reflector. Overall system efficiency is kept high by making the twist reflector large enough to catch the Vlasov converter sidelobe power, which is partially due to mode conversion in the waveguide system. The launcher design and laboratory measurements are discussed. 3 refs., 3 figs

  7. Construction and initial operation of the Advanced Toroidal Facility

    International Nuclear Information System (INIS)

    The Advanced Toroidal Facility (ATF) torsatron was designed on a physics basis for access to the second stability regime and on an engineering basis for independent fabrication of high-accuracy components. The actual construction, assembly, and initial operation of ATF are compared with the characteristics expected during the design of ATF. 31 refs., 19 figs., 2 tabs

  8. Design description of the Advanced Toroidal Facility

    International Nuclear Information System (INIS)

    The Advanced Toroidal Facility (ATF) is a large torsatron being designed at Oak Ridge National Laboratory (ORNL) to replace the Impurity Study Experiment (ISX-B) tokamak. ATF will have a major radius of 2.1 m and an average plasma minor radius of 0.3 m. Major components of the device include the coil sets, structure, and vacuum vessel. The coil sets are designed for broad operating envelopes, including the capability to drive up to 100 kA of plasma current, to produce helical axis configurations, and to operate continuously at one-half the baseline currents. The ATF structure consists of a 40-mm-thick stainless steel toroidal shell encasing the helical coil set. The shell is constructed from 24 identical upper and lower segments, with 12 pairs of intermediate panels to provide access to the helical field (HF) coil joints. The lower portion of the shell also serves as an assembly fixture for the HF coil set. The vacuum vessel is a highly contoured 6-mm-thick stainless steel shell closely fitting the bore and sidewalls of the HF coil winding to provide maximum volume for the plasma. Forty-eight large ports allow good access for diagnostics and neutral beam injection

  9. Advanced toroidal facility vaccuum vessel stress analyses

    International Nuclear Information System (INIS)

    The complex geometry of the Advance Toroidal Facility (ATF) vacuum vessel required special analysis techniques in investigating the structural behavior of the design. The response of a large-scale finite element model was found for transportation and operational loading. Several computer codes and systems, including the National Magnetic Fusion Energy Computer Center Cray machines, were implemented in accomplishing these analyses. The work combined complex methods that taxed the limits of both the codes and the computer systems involved. Using MSC/NASTRAN cyclic-symmetry solutions permitted using only 1/12 of the vessel geometry to mathematically analyze the entire vessel. This allowed the greater detail and accuracy demanded by the complex geometry of the vessel. Critical buckling-pressure analyses were performed with the same model. The development, results, and problems encountered in performing these analyses are described. 5 refs., 3 figs

  10. Helical coil alignment in the Advanced Toroidal Facility

    International Nuclear Information System (INIS)

    The Advanced Toroidal Facility (ATF) is comprised of several major structural and magnetic coil systems tightly fitted around a thin helically contoured vacuum vessel. A critical parameter for successful operation of this device is the precise alignment of the various coil systems, with particular emphasis on the exact positioning of the helical field (HF) coils. This paper presents a brief overview of the helical coil design concept, detailed descriptions of the method for installation and alignment, and discussions of segment installation and alignment equipment. Alignment is accomplished by optical methods using electronic theodolites connected to a microcomputer to form a coordinate measurement system. The coordinate measurement system is described in detail, along with target selection and fixturing for manipulation of the helical coil segments during installation. In addition, software is described including vendor-supplied software used in the coordinate measurement system and in-house-developed software used to calibrate segment and positioning fixture motion

  11. Fabrication and installation of the vacuum vessel for the Advanced Toroidal Facility

    International Nuclear Information System (INIS)

    The vacuum vessel for the Advanced Toroidal Facility (ATF) has been completed and installed in the facility. The vessel fabrication has involved many unique methods to correct unanticipated problems. The primary fabrication concern has been to correct for dimensional inconsistency so that the vessel would fit into the closely nested helical coil set. The vessel has been installed and the remainder of the facility components are being assembled

  12. Highlights from the assembly of the helical field coils for the Advanced Toroidal Facility

    International Nuclear Information System (INIS)

    The helical field (HF) coils in the Advanced Toroidal Facility (ATF) device consist of a set of 24 identical segments connected to form a continuous pair of helical coils wrapped around a toroidal vacuum vessel. Each segment weighs approximately 1364 kg (3000 lb) and is composed of 14 water-cooled copper plate conductors bolted to a cast stainless steel structural support member with a T-shape cross section (known as the structural tee). The segment components are electrically insulated with Kapton adhesive tape, G-10, Tefzel, and rubber to withstand 2.5 kV. As a final insulator and structural support, the entire segment is vacuum impregnated with epoxy. This paper offers a brief overview of the processes used to assemble the component parts into a completed segment, including identification of items that required special attention. 4 figs

  13. Design and fabrication of the vacuum vessel for the Advanced Toroidal Facility

    International Nuclear Information System (INIS)

    The vacuum vessel for the Advanced Toroidal Facility (ATF) is a heavily contoured and very complex formed vessel that is specifically designed to allow for maximum plasma volume in a pure stellarator arrangement. The design of the facility incorporates an internal vessel that is closely fitted to the two helical field coils following the winding law theta = 1/6phi. Metallic seals have been incorporated throughout the system to minimize impurities. The vessel has been fabricated utilizing a comprehensive set of tooling fixtures specifically designed for the task of forming 6-mm stainless steel plate to the complex shape. Computer programs were used to develop a series of ribs that essentially form an internal mold of the vessel. Plates were press-formed with multiple compound curves, fitted to the fixture, and joined with full-penetration welds. 7 refs., 8 figs

  14. Recent progress on ATF

    International Nuclear Information System (INIS)

    The ATF experiment will test improvements to high-beta, steady-state toroidal confinement using external helical fields. The device design has been optimized to (1) provide direct access to the high-beta second-stability regime, (2) have sufficient flexibility to study a large range of toroidal configurations both with and without plasma current, (3) test the reduction of low-collisionality transport by EXB drifts induced by the self-consistent radial electric field, and (4) permit steady-state, high-beta operation without disruptions. Continued physics studied at ORNL and recent results from foreign stellarator experiments have increased confidence in ATF performance

  15. Absence of second stability in ATF

    Energy Technology Data Exchange (ETDEWEB)

    Dominguez, N.; Lynch, V.E.

    1995-07-01

    Ideal Mercier and ballooning modes for three-dimensional (3-D) equilibria of the Advanced Toroidal Facility (ATF) are studied in detail. These modes are found to introduce instability limits at modest beta values for pressure profiles for which previous results, based on a two-dimensional (2-D) equilibrium approximation, predicted the existence of a second stability region. This absence of second stability is in agreement with an analysis by Cooper et al. who used a simplified model for the ATF plasma boundary. The increased instability is found to result from the 3-D feature of the Pfirsch-Schlueter current. Furthermore, a strong quadrupole field is found to decrease the beta limit of these modes, contrary to the results obtained using the 2-D equilibria. Although direct comparison with measured beta values is not possible owing to the absence of profile data for ATF plasmas, pressure profiles used previously to model ATF data as well as in the 2-D analysis are used to obtain the results. The details of the pressure profiles and the plasma configurations strongly influence the stability limits on average beta which remains below 3%.

  16. Recent advances in the stability theory of toroidal plasmas

    International Nuclear Information System (INIS)

    Many of the most persistent instabilities of a magnetically confined plasma have short wavelength perpendicular to the magnetic field but long wavelength parallel to it. Such instabilities are difficult to treat in a toroidal system because the simple eikonal representation of short wavelength oscillations. X(r) = Y(r) esup(iS(r)/γ) with γ << 1 proves to be incompatible with the other requirements of toroidal periodicity and long parallel wavelength (which would require BETA.ΔS = O). A new method of representing perturbations in a torus will be outlined. By using this, the two-dimensional stability problem posed by an axisymmetric toroidal equilibrium can be reduced to that of solving a one-dimensional eigenvalue equation. This technique essentially completes the linear stability theory of magnetohydrodynamic modes in a toroidal plasma, and is also applicable to the investigation of micro-instabilities that are described by the Vlasov-Maxwell equations. (author)

  17. The first terawatt picosecond CO2 laser for advanced accelerator studies at the Brookhaven ATF

    International Nuclear Information System (INIS)

    The first terawatt picosecond C02 laser system is under development at the Brookhaven Accelerator Test Facility. Presently operational 1 Joule 100-ps ATF laser will be upgraded with a 10 atm amplifier capable of delivery ∼ 15 Joules of laser energy in a 3 ps pulse. We describe the design of the x-ray preionized 10 atm amplifier of a 10 liter active volume energized by a 1 MV, 200 kA transverse electric discharge. The amplifier, equipped with internal optics, permits the accommodation of a regenerative stage and a multi-pass booster in a relatively compact single discharge volume. The ATF terawatt C02 laser shall become operational in 1997 to serve for laser acceleration, x-ray generation and other strong-field physics experiments

  18. The operation of the BNL/ATF gun-IV photocathode RF gun at the Advanced Photon Source

    International Nuclear Information System (INIS)

    At the Advanced Photon Source (APS) at Argonne National Laboratory (ANL), a free-electron laser (FEL) based on the self-amplified spontaneous emission (SASE) process is nearing completion. Recently, an rf photoinjector gun system was made available to the APS by Brookhaven National Laboratory/Accelerator Test Facility (BNL/ATF). It will be used to provide the high-brightness, low-emittance, and low-energy spread electron beam required by the SASE FEL theory. A Nd:Glass laser system, capable of producing a maximum of 500 microJ of UV in a 1-10 ps pulse at up to a 10-Hz repetition rate, serves as the photoinjector's drive laser. Here, the design, commissioning, and integration of this gun with the APS is discussed

  19. ATF neutral beam injection: optimization of beam alignment and aperturing

    International Nuclear Information System (INIS)

    The application of the existing Impurity Study Experiment (ISX-B) neutral beam injectors for the Advanced Toroidal Facility (ATF) is studied. It is determined that with the practical considerations of beam aperturing, ATF vacuum vessel complexity, and realistic beam modeling, the power absorbed by the plasma will be approximately 57% of the extracted neutral beam power, which corresponds to an injected power of about 1.5 MW. By reducing the beam divergence to a 10 Gaussian distribution, the absorbed power could be increased to 93%. The power delivered to the plasma is found to be a strong function of the beam divergence but only a weak function of the beam focal length. Shinethrough can be a serious problem if very low density startups are necessary. Preliminary calculations indicate that there will be no excessive fast-ion losses. 12 refs., 17 figs., 1 tab

  20. Advances in the Fabrication of Toroidal Field Coil Prototypes*

    Science.gov (United States)

    Pizzuto, A.; Cucchiaro, A.; Frosi, R.; Ramogida, G.; Boert, F.; Wobker, H. G.; Bianchi, A.; Parodi, B.; Coppi, B.

    2006-10-01

    The Bitter-type Toroidal Field Coils (TFC) adopted for Ignitor consist of plates that are cooled down to 30 K by Helium gas. Copper OFHC has been selected for these plates, allowing for an Electron Beam (EB) welding solution of the cooling channels. Kabel Metal set up the welding parameters and qualified the process to achieve full joint penetration with acceptable metallurgical structure. The qualification covers both the welding of the cooling channels and the inlet/outlet tube made on two full size samples. A metallographic examination and vacuum and pressure tests have been preformed to validate the basic suitability of the EB welding process. *Sponsored in part by ENEA of Italy and by the U.S. DOE.

  1. Computer simulation of magnetic field circuits in ATF

    International Nuclear Information System (INIS)

    The proposed design of the Advanced Toroidal Facility (ATF) contains several closely coupled magnetic field circuits that are being modeled using the SUPER*SCEPTRE computer program in order to predict their transient behavior. The results of this transient analysis study will be used to determine component values and/or special precautions that may be required for power supply and other circuit element protection due to the mutual coupling between circuits. ATF is a continuous-coil torsatron device using resistive coils in a pulsed mode of operation in which a current fluctuation in one coil induces voltages in the other circuit element protection due to the mutual coupling between circuits. ATF is a continuous-coil torsatron device using resistive coils in a pulsed mode of operation in which a current fluctuation in one coil induces voltages in the other circuit that may not be desirable. The model contains the solid-state power supplies' equivalent circuits, the resistance and self-inductance of each magnetic field coil, and the mutual inductances of every coil combination. The SUPER*SCEPTRE program allows for the direct input of all electrical components as well as the mutual inductances. The power supply voltages are entered as preprogrammed wave shapes designed to achieve the desired magnetic field strengths. The outputs of this program are tables and plots of voltages and currents associated with each circuit component

  2. Plans for improvements to the ATF ECH system

    International Nuclear Information System (INIS)

    The Advanced Toroidal Facility (ATF) stellarator experiment at Oak Ridge National Laboratory (ORNL) uses electron cyclotron waves for plasma formation and heating. Although the existing systems are quite reliable and produce acceptable plasmas, a few deficiencies should be corrected. Therefore, several possible upgrades to the electron cyclotron heating (ECH) systems have been planned. Some of the desirable changes are (1) improving the launcher to make power deposition in the plasma more centralized,(2) improving the gyrotron power waveform monitoring diagnostics, (3) building a high-field launch system for higher density operation at 53-GHz (4) building a separate transmission line for the 35-GHz gyrotron, and (5) installing a higher frequency, higher power (84- or 110-GHz) gyrotron system for improved plasma density and temperature capability. This paper discusses options for these, improvements and conceptual designs

  3. Recent results on cleaning and conditioning the ATF vacuum system

    International Nuclear Information System (INIS)

    Techniques for cleaning and conditioning the vacuum vessel of the Advanced Toroidal Facility (ATF) and its internal components are described. The vacuum vessel cleaning technique combines baking to 150 degree C and glow discharges with hydrogen gas. Chromium gettering is used to further condition the system. The major internal components are the anodized aluminum baffles in the Thomson scattering system, a graphite-shielded ICRF antenna, two graphite limiters, and a diagnostic graphite plate. Three independent heating systems are used to bake some of the major components of the system. The major characteristics used for assessing cleanliness and conditioning progress are the maximum pressure attained during bakeout, the results of gas analysis, and revelant plasma parameters (e.g., time to radiative decay). Details of the various cleaning and conditioning procedures and results are presented

  4. BNL ATF II beamlines design

    International Nuclear Information System (INIS)

    The Brookhaven National Laboratory. Accelerator Test Facility (BNL ATF) is currently undergoing a major upgrade (ATF-II). Together with a new location and much improved facilities, the ATF will see an upgrade in its major capabilities: electron beam energy and quality and CO2 laser power. The electron beam energy will be increased in stages, first to 100-150 MeV followed by a further increase to 500 MeV. Combined with the planned increase in CO2 laser power (from 1-100 TW), the ATF-II will be a powerful tool for Advanced Accelerator research. A high-brightness electron beam, produced by a photocathode gun, will be accelerated and optionally delivered to multiple beamlines. Besides the energy range (up to a possible 500 MeV in the final stage) the electron beam can be tailored to each experiment with options such as: small transverse beam size (<10 um), short bunch length (<100 fsec) and, combined short and small bunch options. This report gives a detailed overview of the ATFII capabilities and beamlines configuration.

  5. BNL ATF II beamlines design

    Energy Technology Data Exchange (ETDEWEB)

    Fedurin, M. [Brookhaven National Lab. (BNL), Upton, NY (United States); Jing, Y. [Brookhaven National Lab. (BNL), Upton, NY (United States); Stratakis, D. [Brookhaven National Lab. (BNL), Upton, NY (United States); Swinson, C. [Brookhaven National Lab. (BNL), Upton, NY (United States)

    2015-05-03

    The Brookhaven National Laboratory. Accelerator Test Facility (BNL ATF) is currently undergoing a major upgrade (ATF-II). Together with a new location and much improved facilities, the ATF will see an upgrade in its major capabilities: electron beam energy and quality and CO2 laser power. The electron beam energy will be increased in stages, first to 100-150 MeV followed by a further increase to 500 MeV. Combined with the planned increase in CO2 laser power (from 1-100 TW), the ATF-II will be a powerful tool for Advanced Accelerator research. A high-brightness electron beam, produced by a photocathode gun, will be accelerated and optionally delivered to multiple beamlines. Besides the energy range (up to a possible 500 MeV in the final stage) the electron beam can be tailored to each experiment with options such as: small transverse beam size (<10 um), short bunch length (<100 fsec) and, combined short and small bunch options. This report gives a detailed overview of the ATFII capabilities and beamlines configuration.

  6. Advances in the simulation of toroidal gyro Landau fluid model turbulence

    International Nuclear Information System (INIS)

    The gyro-Landau fluid (GLF) model equations for toroidal geometry have been recently applied to the study ion temperature gradient (ITG) mode turbulence using the 3D nonlinear ballooning mode representation (BMR). The present paper extends this work by treating some unresolved issues conceming ITG turbulence with adiabatic electrons. Although eddies are highly elongated in the radial direction long time radial correlation lengths are short and comparable to poloidal lengths. Although transport at vanishing shear is not particularly large, transport at reverse global shear, is significantly less. Electrostatic transport at moderate shear is not much effected by inclusion of local shear and average favorable curvature. Transport is suppressed when critical ExB rotational shear is comparable to the maximum linear growth rate with only a weak dependence on magnetic shear. Self consistent turbulent transport of toroidal momentum can result in a transport bifurcation at suffciently large r/(Rq). However the main thrust of the new formulation in the paper deals with advances in the development of finite beta GLF models with trapped electron and BMR numerical methods for treating the fast parallel field motion of the untrapped electrons

  7. Electron temperature measurements on ATF using electron cyclotron emission

    International Nuclear Information System (INIS)

    Second and third harmonic electron cyclotron emission measurements have been carried out on the Advanced Toroidal Facility (ATF) at Oak Ridge National Laboratory. ATF is a 1=2, m=12 torsatron with a major radius of 2.1m and an average plasma radius of 0.3m. At the standard magnetic field values of 1T and 2T, we have used heterodyne receivers with fixed frequency Gunn local oscillators. The optically thick second harmonic emission has been used to monitor the electron temperature profile as a function of time. The optically thin third harmonic emission has been used to measure the central electron temperature during ECH and Neutral Beam Injection. Results from both harmonics agree well with the Thomson scattering data. Calculations of the width of the resonance zones indicate values from 1 cm at the edge to 5 cm centrally. An in-situ absolute calibration of the system using a liquid nitrogen source has been performed. The beam pattern of the system has also been measured in-situ and agrees well with theoretical calculations. A beam viewing dump has been installed to reduce the wall reflection problem for the optically thin emission. (author)

  8. ATF2 Proposal

    Energy Technology Data Exchange (ETDEWEB)

    Grishanov, Boris Ivanovich; Logachev, Pavel; Podgorny, Fedor; Telnov, Valery; /Novosibirsk, IYF; Angal-Kalinin, Deepa; Appleby, Robert; Jones, James; Kalinin, Alexander; /Daresbury; Napoly, Olivier; Payet, Jacques; /DAPNIA, Saclay; Braun, Hans-Heinrich; Schulte, Daniel; Zimmermann, Frank; /CERN; Barlow, Roger; Bailey, Ian; Jenner, Leo; Jones, Roger; Kourevlev, German; /Daresbury; Walker, Nick; /DESY; Takahasi, Tohru; /Hiroshima U.; Gao, Jie; /Beijing, Inst. High Energy Phys. /Oxford U. /KEK, Tsukuba /Kyoto U., Inst. Chem. Res.

    2005-08-23

    This document is the first of two volumes describing the ATF2 project. The present volume discusses the technical justification for ATF2 and presents a design description. Since the International Committee for Future Accelerator (ICFA) decision on the choice of technology, a world-wide collaboration on the design of the International Linear Collider (ILC) has rapidly progressed [1]. The formation of the Global Design Effort (GDE) will accelerate the work towards a final design. An important technical challenge is obviously the high gradient acceleration but what is similarly challenging is the collision of extremely small beams of a few nanometer size. The latter challenge has three distinct issues: creating small emittance beams, preserving the emittance during acceleration and transport, and focusing the beams to nanometers. Most studies have been done using computer simulations but many issues still remain that require experimental verification. Accelerator Test Facility (ATF) at KEK was built to create small emittance beams, and succeeded in obtaining an emittance that almost satisfies the ILC requirements [2]. In this proposal we present a project, ATF2, which addresses the focusing of the beam into a nanometer spot. The ATF2 project will extend the extraction beamline of the ATF with an ILC-type final focus system to create a tightly focused, stable beam by making use of the small emittance of the ATF. The layout is shown in Figure 1.1. In the longer term, the ATF2 project would also provide invaluable input for the CLIC design of a future multi-TeV collider.

  9. ATF2 Proposal

    International Nuclear Information System (INIS)

    This document is the first of two volumes describing the ATF2 project. The present volume discusses the technical justification for ATF2 and presents a design description. Since the International Committee for Future Accelerator (ICFA) decision on the choice of technology, a world-wide collaboration on the design of the International Linear Collider (ILC) has rapidly progressed [1]. The formation of the Global Design Effort (GDE) will accelerate the work towards a final design. An important technical challenge is obviously the high gradient acceleration but what is similarly challenging is the collision of extremely small beams of a few nanometer size. The latter challenge has three distinct issues: creating small emittance beams, preserving the emittance during acceleration and transport, and focusing the beams to nanometers. Most studies have been done using computer simulations but many issues still remain that require experimental verification. Accelerator Test Facility (ATF) at KEK was built to create small emittance beams, and succeeded in obtaining an emittance that almost satisfies the ILC requirements [2]. In this proposal we present a project, ATF2, which addresses the focusing of the beam into a nanometer spot. The ATF2 project will extend the extraction beamline of the ATF with an ILC-type final focus system to create a tightly focused, stable beam by making use of the small emittance of the ATF. The layout is shown in Figure 1.1. In the longer term, the ATF2 project would also provide invaluable input for the CLIC design of a future multi-TeV collider

  10. ATF2 Proposal Vol.2

    OpenAIRE

    ATF2 Group

    2006-01-01

    The two major goals for this facility, called ATF2, are : (A) Achievement of a 37 nm beam size, and (B) control of beam position down to 2 nm level. The scientific justification for the ATF2 project and its technical design have been described in Volume 1 of the ATF2 Proposal. We present here Volume 2 of the ATF2 Proposal, in which we present specifics of the construction plans and the group organization to execute the research programs at ATF2.

  11. Control system of ATF

    International Nuclear Information System (INIS)

    A computer control system of Accelerator Test Facility(ATF) is described in detail. The ATF presently consists of 60MeV electron injector linac and two klystron Lest stands, and is controlled by a workstation computer with CAMAC interfaces. For its nature of R and D accelerator aimed to realize TeV region linear collider, the control system also should have a flexibility in both hardware and software. Programmable sequence controllers are introduced in the electron gun system and klystron modulator systems and their performances are tested. The control software which is coded using FORTRAN consists in many independent programs. Each program can access to full functions of a specified device or can control the function which is common to many devices

  12. Radial electric field in JET advanced tokamak scenarios with toroidal field ripple

    International Nuclear Information System (INIS)

    A dedicated campaign has been run on JET to study the effect of toroidal field (TF) ripple on plasma performance. Radial electric field measurements from experiments on a series of plasmas with internal transport barriers (ITBs) and different levels of ripple amplitude are presented. They have been calculated from charge exchange measurements of impurity ion temperature, density and rotation velocity profiles, using the force balance equation. The ion temperature and the toroidal and poloidal rotation velocities are compared in plasmas with both reversed and optimized magnetic shear profiles. Poloidal rotation velocity (vθ) in the ITB region is measured to be of the order of a few tens of km s-1, significantly larger than the neoclassical predictions. Increasing levels of the TF ripple are found to decrease the ion temperature gradient in the ITB region, a measure for the quality of the ITB, and the maximum value of vθ is reduced. The poloidal rotation term dominates in the calculations of the total radial electric field (Er), with the largest gradient in Er measured in the radial region coinciding with the ITB.

  13. Advancing High Current Startup via Localized Helicity Injection in the PEGASUS Toroidal Experiment

    Science.gov (United States)

    Hinson, E. T.; Barr, J. L.; Bongard, M. W.; Burke, M. G.; Fonck, R. J.; Perry, J. M.; Redd, A. J.; Schlossberg, D. J.

    2013-10-01

    Non-solenoidal startup via local helicity injection (LHI) and poloidal field induction is used to produce Ip = 0 . 17 MA tokamak discharges. Impurity contamination has been reduced to negligible levels by use of conical frustum cathode geometry and local scraper limiters. Attainable currents are governed by global limits of helicity and energy balance, and Taylor relaxation. A simple lumped parameter model based on these limits is used to project discharge evolution, and indicates that attaining 1 MA in NSTX-U will require LHI-driven effective loop voltages to dominate contributions from dLp / dt . This regime contrasts with results to date and will be tested at 0.3 MA in PEGASUS with a new integrated multi-injector array. Injector impedance characteristics are consistent with magnetically-limited regimes observed in higher-power foilless diodes. Bursts of MHD are measured on time scales of order ~ 100 μ s, and correlate with rapid equilibrium changes, discrete rises in Ip, redistribution of the toroidal current, ion heating (Ti ~ 1 keV), transient drops in injector voltage, and apparent n = 1 line-tied kink activity at the injector. NIMROD simulations of high-field-side HI discharges in PEGASUS are in qualitative agreement, suggesting Ip buildup results from inward propagating toroidal current loops created by intermittent reconnection of injected current streams. Work supported by US DOE Grant DE-FG02-96ER54375.

  14. ATF2 Proposal Volume 2

    Energy Technology Data Exchange (ETDEWEB)

    Grishanov, B.I.; Logachev, P.; Podgorny, F.; Telnov, V.; /Novosibirsk, IYF; Angal-Kalinin, D.; Jones, J.; Kalinin, A.; /Daresbury; Napoly, O.; Payet, J.; /DAPNIA, Saclay; Braun, H.H.; Schulte, D.; Zimmermann, F.; /CERN; Appleby, R.; Barlow, R.; Bailey, I.; Jenner, L.; Jones, R.; Kourevlev, G.; /Cockcroft Inst.; Elsen, E.; Vogel, V.; Walker, N.; /DESY

    2006-02-27

    For achieving the high luminosity required at the International Linear Collider (ILC), it is critical to focus the beams to nanometer size with the ILC Beam Delivery System (BDS), and to maintain the beam collision with a nanometer-scale stability. To establish the technologies associated with this ultra-high precision beam handling, it has been proposed to implement an ILC-like final focus optics in an extension of the existing extraction beamline of ATF at KEK. The ATF is considered to be the best platform for this exercise, since it provides an adequate ultra-low emittance electron beam in a manner dedicated to the development of ILC. The two major goals for this facility, called ATF2, are: (A) Achievement of a 37 nm beam size, and (B) control of beam position down to 2 nm level. The scientific justification for the ATF2 project and its technical design have been described in Volume 1 of the ATF2 Proposal [1]. We present here Volume 2 of the ATF2 Proposal, in which we present specifics of the construction plans and the group organization to execute the research programs at ATF2. The sections in this report have been authored by relevant ATF2 subgroups within the International ATF Collaboration. The time line of the project is described in Section 2. Section 3 discuss the structure of the international collaboration. Sections 4 and 5 discuss budget considerations, which are presented as well as the design and construction tasks to be shared by the international collaboration at ATF2. Concluding remarks have been contributed by Dr. Ewan Paterson, Chair of the International Collaboration Board of the ATF collaboration.

  15. Status of ATF, 2004

    International Nuclear Information System (INIS)

    Accelerator Test Facility (ATF) has already achieved the vertical emittance of GLC specification. In order to make the multi-bunch emittance achievement, high quality multi-bunch beam from photo-cathode rf gun was employed. The maximum allowable current was raised to 3 times more. From the study, it was found that the vacuum level of damping ring is related to the achieved vertical emittance. The ring scrubbing with high current accumulation made tail bunch emittance growth lower. We describe the status of multi-bunch emittance study together with the development status of the various emittance monitors and beam position monitors. (author)

  16. Advanced Power Conversion Efficiency in Inventive Plasma for Hybrid Toroidal Reactor

    Science.gov (United States)

    Hançerlioğullari, Aybaba; Cini, Mesut; Güdal, Murat

    2013-08-01

    Apex hybrid reactor has a good potential to utilize uranium and thorium fuels in the future. This toroidal reactor is a type of system that facilitates the occurrence of the nuclear fusion and fission events together. The most important feature of hybrid reactor is that the first wall surrounding the plasma is liquid. The advantages of utilizing a liquid wall are high power density capacity good power transformation productivity, the magnitude of the reactor's operational duration, low failure percentage, short maintenance time and the inclusion of the system's simple technology and material. The analysis has been made using the MCNP Monte Carlo code and ENDF/B-V-VI nuclear data. Around the fusion chamber, molten salts Flibe (LI2BeF4), lead-lithium (PbLi), Li-Sn, thin-lityum (Li20Sn80) have used as cooling materials. APEX reactor has modeled in the torus form by adding nuclear materials of low significance in the specified percentages between 0 and 12 % to the molten salts. In this study, the neutronic performance of the APEX fusion reactor using various molten salts has been investigated. The nuclear parameters of Apex reactor has been searched for Flibe (LI2BeF4) and Li-Sn, for blanket layers. In case of usage of the Flibe (LI2BeF4), PbLi, and thin-lityum (Li20Sn80) salt solutions at APEX toroidal reactors, fissile material production per source neutron, tritium production speed, total fission rate, energy reproduction factor has been calculated, the results obtained for both salt solutions are compared.

  17. ATF neutral beam injection system

    International Nuclear Information System (INIS)

    The Advanced Toroidal Facility is a stellarator torsatron being built at Oak Ridge National Laboratory to investigate improved plasma confinement schemes. Plasmas heating will be carried out predominantly by means of neutral beam injection. This paper describes the basic parameters of the injection system. Numerical calculations were done to optimize the aiming of the injectors. The results of these calculations and their implications on the neutral power to the machine are elaborated. The effects of improving the beam optics and altering the focal length on the power transmitted to the plasma are discussed

  18. ATF beam image monitor software

    International Nuclear Information System (INIS)

    We report about software for the beam image analysis at ATF. We developed image analysis software with a Linux computer. It acquire image data from a video and an IEEE1394 digital camera of the analog. (author)

  19. ATF2 Proposal v. 2

    CERN Document Server

    Grishanov, B I; Alabau-Pons, M; Angal-Kalinin, Deepa; Appleby, R; Araki, S; Bailey, I; Bambade, P; Bane, Karl Leopold Freitag; Barlow, R; Blair, G A; Bolzon, B; Boorman, G; Bosco, A; Brachmann, A; Braun, Hans Heinrich; Burrows, P N; Carter, J; Choi, J; Christian, Glenn B; Clarke, C; Dabiri-Khah, A; Dadoun, O; Danagulyan, S; Delerue, N; Dixit, S; Driouichi, C; Elsen E; Gao, J; Geffroy, N; Gronberg, J; Hartin, Anthony F; Hayano, H; Higashi, Y; Himel, T; Honda, Y; Howell, D; Huang, J Y; Iwashita, Y; Jenner, L; Jones, J; Jones, R; Jérémie, A; Kalinin, A; Kanazawa, K; Kang, H S; Karyotakis, Yu; Kim, E S; Kim, S; Komamiya, S; Kourevlev, German Yu; Kubo, K; Kumada, M; Kume, T; Kuriki, M; Kuroda, S; Liu, W; Logatchev, P V; Lyapin, A; Malton, S; Markiewicz, T W; Masuzawa, M; Mihara, T; Miller, D J; Molloy, S; Mtingwa, S; Naito, T; Nan-Phinney, Y; Napoly, O; Nelson, J; Okugi, T; Payet, J; Pei, G X; Pivi, M T F; Podgorny, F; Price, M; Raubenheimer, T O; Reichold, A; Ross, M; Sanuki, T; Schulte, Daniel; Seryi, R A; Solyak, N; Soo Ko In; Spencer, C M; Suehara, T; Sugahara, R; Takahashi, T; Takashi-Boogert, S; Tauchi, T; Telnov, Valery I; Tenenbaum, P G; Terunuma, N; Toge, N; Torrence, E; Urakawa, J; Urner, D; Vogel, V; Walker, N; Wang, J Q; Wendt, M; White, G; Wing, M; Wolski, A; Woodley, M; Yamaoka, H; Yokoya, K; Zimmermann, Frank

    2006-01-01

    For achieving the high luminosity required at the International Linear Collider (ILC), it is critical to focus the beams to nanometer size with the ILC Beam Delivery System (BDS), and to maintain the beam collision with a nanometer-scale stability. To establish the technologies associated with this ultra-high precision beam handling, it has been proposed to implement an ILC-like final focus optics in an extension of the existing extraction beamline of ATF at KEK. The ATF is considered to be the best platform for this exercise, since it provides an adequate ultra-low emittance electron beam in a manner dedicated to the development of ILC. The two major goals for this facility, called ATF2, are : (A) Achievement of a 37 nm beam size, and (B) control of beam position down to 2 nm level. The scientific justification for the ATF2 project and its technical design have been described in Volume 1 of the ATF2 Proposal [1]. We present here Volume 2 of the ATF2 Proposal, in which we present specifics of the construction...

  20. Structural design and analysis for the ISX-C/ATF tokamak of the vacuum vessel, coil joints, and supports

    International Nuclear Information System (INIS)

    The ISX-C/ATF is being designed as a test bed for advanced toroidal concepts. Because of numerous design concepts being evaluated, a flexible, easily changeable structural-design math-model was needed to afford quick evalution of the structural feasibility of the many proposed concepts. To satisfy this need, the NASTRAN Automated Multi-Stage Substructures technique was used to build a quick-changeable math model. This technique was especially needed because all the coils, first wall and diagnostic devices are to be supported by the vacuum vessel, requiring the entire structure to be analyzed as a system. Without the use of the substructuring technique, the required man hours and computer core would have made timely design analysis impossible. To illustrate the technique, the detailed design analysis of the concept Torsatron (with helical coils and T.F. coils) is presented

  1. Toroidal Nematics

    Science.gov (United States)

    Fernandez-Nieves, Alberto

    We will discuss how nematic liquid crystals organize inside toroidal droplets. When the director is parallel to the bounding surface, we find spontaneous reflection symmetry breaking, which we attribute to the role played by saddle-splay contributions to the Frank free energy. When the director is perpendicular to the bounding surface, we find that the structure is reminiscent of the escape radial configuration seen in cylinders, but with a central doubly-twisted organization, which we attribute to the geometry of the torus. We will end by presenting recent experiments with active nematics on the toroidal surface. In this case, topology and activity both affect the structure and dynamics of the material.

  2. Advanced toroidal theory

    International Nuclear Information System (INIS)

    At high collisionality the neoclassical theory of transport in tokamaks predicts that the electron confinement time τe will exceed the ion confinement time τi by a factor roughly equal to the square root of the mass ratio mi/me. If the energy confinement time τE is calculated from the normalized particle confinement time τ through division by an emperical factor of three times the magnetic field strength B, then the theoretical confinement time of the ions exceeds experimental measurements by a factor of as much as three. The prediction that the electron confinement time will be two orders of magnitude larger is referred to as anomalous electron transport. We assert that the anomaly can be explained by imposing a strict requirement of quasineutrality to determine the electric potential instead of allowing it to be found from conservation of momentum. Numerical evidence for this contention is provided by performing Monte Carlo calculations based on a fast new computer code called TRAN

  3. Advanced toroidal theory

    International Nuclear Information System (INIS)

    This report briefly discusses the following topics: equilibrium and transport; including turbulent transport; stability; wave propagation; statistical data analysis; computational algorithms and computer simulations; and general plasma science

  4. Fluctuations and confinement in ATF

    International Nuclear Information System (INIS)

    In the period immediately prior to the suspension of ATF operation in November, 1991, a great deal of emphasis was palced on investigations of the fundamental mechanisms controlling confinement in this device. At that time, measurements of the density fluctuations throughout the plasma volume indicated the existence of theoretically predicted dissipative trapped electron and resistive interchange instabilities. These identifications were supported by results of dynamic configuration scans of the magnetic fields during which the extent of the magnetic well, shear, and fraction of confined trapped particles were changed continuously. Interpretation of the data from these experiments has been an ongoing exercise. Most recently, analysis of discharges employing strong gas puffing to change density gradients and fluctuation levels have strengthened the view that dissipative trapped electron modes may be present but do not play a significant direct role in energy transport. The present paper summarizes the current understanding concerning the identification of instabilities and their relationship to confinement in ATF

  5. Location and repair of air leaks in the ATF vacuum vessel

    International Nuclear Information System (INIS)

    On the basis of partial pressure rate-of-rise and base pressure measurements, it was determined that the Advanced Toroidal Facility (ATF) vacuum vessel had an air leak in the low 10-4 mbarx ell/s range. Pinpointing this leak by conventional helium leak-checking procedures was not possible, because large portions of the outside of the vessel are covered by the helical field coils and a structural shell. Various alternative leak detection schemes that were considered are summarized and their advantages and disadvantages noted. In the method ultimately employed, gum-rubber patches of various sizes ranging from 12.7 by 12.7 cm to 20.3 by 30.5 cm were positioned on the inside surfaces of the vessel and evacuated by the leak detector (LD). After roughly 5% of the surface was inspected in this way, a leak of >10-5 mbar xL/s was discovered and localized to an area of 5 by 5 cm. Dye penetrant applied to this area disclosed three pinholes. Two small slag pockets were discovered while these points were being ground out. After these were rewelded, no further leakage could be found in the repaired area. Global leak rates measured after the machine was reevacuated indicated that this leak was about 30% of the overall leak rate. 1 ref., 5 figs., 1 tab

  6. The design and fabrication of a toroidally continuous cryocondensation pump for the DIII-D Advanced Divertor

    International Nuclear Information System (INIS)

    A cryocondensation pump will be installed in the baffle chamber of the DIII-D tokamak in the spring of 1992. The design is complete and fabrication of this pump is in progress. The purpose of the pump is to study plasma density control by pumping the divertor. The pump is toroidally continuous, approximately 10 m long, in the lower outer corner of the vacuum vessel interior. It consists of a 1 m2 liquid helium cooled surface surrounded by a liquid nitrogen cooled shield to limit the heat load on the helium cooled surface. The stainless steel liquid nitrogen shell has a copper coating on it to enhance thermal conductivity, but the coating is broken to keep the toroidal electrical resistance high. The liquid nitrogen cooled surface is surrounded by a radiation/particle shield to prevent energetic particles from impacting and releasing condensed water molecules. The whole pump is supported off the water cooled vacuum vessel wall. Key design considerations were: how to accommodate the temperature differences between the various components, developing low heat leak paths for the various supports, and maintaining electrical insulation in a low pressure environment in the presence of induced voltage spikes. A single point ground for the system was used to limit disruption induced currents and the resulting electro-mechanical forces on the pump. A testing program was used to develop coating techniques to enhance heat transfer and emissivity of the various surfaces. Fabrication tests were done to determine the best method of attaching the liquid nitrogen flow tubes to their shield surfaces. A prototype sector of the pump was built to verify fabrication and assembly techniques

  7. Analytical estimation of ATF beam halo distribution

    CERN Document Server

    Wang, Dou; Yokoya, Kaoru; Gao, Jie

    2013-01-01

    In order to study the background status in the ATF2 beam line and the interaction point (IP), this paper developed an analytical method to give the estimation of ATF beam halo distribution based on K. Hirata and K. Yokoya's theory. The equilibrium particle distribution of beam tail in ATF damping ring, when each electron is being affected by, in addition to the synchrotron radiation damping effects, several stochastic processes, such as beam-gas scattring, beam-gas bremsstrahlung and intra-beam scattering, was presented. This method is common and can be applied on other electron rings.

  8. Chondrocytic Atf4 regulates osteoblast differentiation and function via Ihh

    OpenAIRE

    Wang, Weiguang; Lian, Na; Ma., Yun; LI, LINGZHEN; Gallant, Richard C.; Elefteriou, Florent; Yang, Xiangli

    2012-01-01

    Atf4 is a leucine zipper-containing transcription factor that activates osteocalcin (Ocn) in osteoblasts and indian hedgehog (Ihh) in chondrocytes. The relative contribution of Atf4 in chondrocytes and osteoblasts to the regulation of skeletal development and bone formation is poorly understood. Investigations of the Atf4–/–;Col2a1-Atf4 mouse model, in which Atf4 is selectively overexpressed in chondrocytes in an Atf4-null background, demonstrate that chondrocyte-derived Atf4 regulates osteog...

  9. The Straightness Monitor System at ATF2

    Energy Technology Data Exchange (ETDEWEB)

    Hildreth, Michael; /Notre Dame U.; Aryshev, Alexander; /Royal Holloway, U. of London; Boogert, Stewart; /Oxford U., JAI; Honda, Yosuke; /KEK, Tsukuba; Tauchi, Toshiaki; /KEK, Tsukuba; Terunuma, Nobuhiro; /KEK, Tsukuba; White, Glen; /SLAC

    2012-07-06

    The demonstration of absolute stability of the position of the focused beam is the primary goal of the ATF2 commissioning effort. We have installed a laser interferometer system that will eventually correct the measurement of high-precision Beam Position Monitors used in the ATF2Final Focus Steering Feedback for mechanical motion or vibrations. Here, we describe the installed system and present preliminary data on the short- and long-term mechanical stability of the BPM system.

  10. Toroidal circular dichroism

    Science.gov (United States)

    Raybould, T. A.; Fedotov, V. A.; Papasimakis, N.; Kuprov, I.; Youngs, I. J.; Chen, W. T.; Tsai, D. P.; Zheludev, N. I.

    2016-07-01

    We demonstrate that the induced toroidal dipole, represented by currents flowing on the surface of a torus, makes a distinct and indispensable contribution to circular dichroism. We show that toroidal circular dichroism supplements the well-known mechanism involving electric dipole and magnetic dipole transitions. We illustrate this with rigorous analysis of the experimentally measured polarization-sensitive transmission spectra of an artificial metamaterial, constructed from elements of toroidal symmetry. We argue that toroidal circular dichroism will be found in large biomolecules with elements of toroidal symmetry and should be taken into account in the interpretation of circular dichroism spectra of organics.

  11. ATF3 inhibits PPARγ-stimulated transactivation in adipocyte cells

    Energy Technology Data Exchange (ETDEWEB)

    Jang, Min-Kyung; Jung, Myeong Ho, E-mail: jung0603@pusan.ac.kr

    2015-01-02

    Highlights: • ATF3 inhibits PPARγ-stimulated transcriptional activation. • ATF3 interacts with PPARγ. • ATF3 suppresses p300-mediated transcriptional coactivation. • ATF3 decreases the binding of PPARγ and recruitment of p300 to PPRE. - Abstract: Previously, we reported that activating transcription factor 3 (ATF3) downregulates peroxisome proliferator activated receptor (PPARγ) gene expression and inhibits adipocyte differentiation in 3T3-L1 cells. Here, we investigated another role of ATF3 on the regulation of PPARγ activity. ATF3 inhibited PPARγ-stimulated transactivation of PPARγ responsive element (PPRE)-containing reporter or GAL4/PPARγ chimeric reporter. Thus, ATF3 effectively repressed rosiglitazone-stimulated expression of adipocyte fatty acid binding protein (aP2), PPARγ target gene, in 3T3-L1 cells. Coimmunoprecipitation and GST pulldown assay demonstrated that ATF3 interacted with PPARγ. Accordingly, ATF3 prevented PPARγ from binding to PPRE on the aP2 promoter. Furthermore, ATF3 suppressed p300-mediated transcriptional coactivation of PPRE-containing reporter. Chromatin immunoprecipitation assay showed that overexpression of ATF3 blocked both binding of PPARγ and recruitment of p300 to PPRE on aP2 promoter induced by rosiglitazone treatment in 3T3-L1 cells. Taken together, these results suggest that ATF3 interacts with PPARγ and represses PPARγ-mediated transactivation through suppression of p300-stimulated coactivation in 3T3-L1 cells, which may play a role in inhibition of adipocyte differentiation.

  12. R and D status of the ATF damping ring

    International Nuclear Information System (INIS)

    The KEK accelerator test facility (ATF) is under construction. This paper gives the status of the design studies, the various R and D works and the construction for the damping ring of the ATF. (author)

  13. ATF3 represses PPARγ expression and inhibits adipocyte differentiation

    Energy Technology Data Exchange (ETDEWEB)

    Jang, Min-Kyung; Jung, Myeong Ho, E-mail: jung0603@pusan.ac.kr

    2014-11-07

    Highlights: • ATF3 decrease the expression of PPARγ and its target gene in 3T3-L1 adipocytes. • ATF3 represses the promoter activity of PPARγ2 gene. • ATF/CRE (−1537/−1530) is critical for ATF3-mediated downregulation of PPARγ. • ATF3 binds to the promoter region containing the ATF/CRE. • ER stress inhibits adipocyte differentiation through downregulation of PPARγ by ATF3. - Abstract: Activating transcription factor 3 (ATF3) is a stress-adaptive transcription factor that mediates cellular stress response signaling. We previously reported that ATF3 represses CCAAT/enhancer binding protein α (C/EBPα) expression and inhibits 3T3-L1 adipocyte differentiation. In this study, we explored potential role of ATF3 in negatively regulating peroxisome proliferator activated receptor-γ (PPARγ). ATF3 decreased the expression of PPARγ and its target gene in 3T3-L1 adipocytes. ATF3 also repressed the activity of −2.6 Kb promoter of mouse PPARγ2. Overexpression of PPARγ significantly prevented the ATF3-mediated inhibition of 3T3-L1 differentiation. Transfection studies with 5′ deleted-reporters showed that ATF3 repressed the activity of −2037 bp promoter, whereas it did not affect the activity of −1458 bp promoter, suggesting that ATF3 responsive element is located between the −2037 and −1458. An electrophoretic mobility shift assay and chromatin immunoprecipitation assay demonstrated that ATF3 binds to ATF/CRE site (5′-TGACGTTT-3′) between −1537 and −1530. Mutation of the ATF/CRE site abrogated ATF3-mediated transrepression of the PPARγ2 promoter. Treatment with thapsigargin, endoplasmic reticulum (ER) stress inducer, increased ATF3 expression, whereas it decreased PPARγ expression. ATF3 knockdown significantly blocked the thapsigargin-mediated downregulation of PPARγ expression. Furthermore, overexpression of PPARγ prevented inhibition of 3T3-L1 differentiation by thapsigargin. Collectively, these results suggest that ATF3-mediated

  14. Analysis list: ATF7IP [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ATF7IP Epidermis + hg19 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/target/ATF7IP....1.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/target/ATF7IP.5.tsv http://dbarchive.biosciencedbc....jp/kyushu-u/hg19/target/ATF7IP.10.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/colo/ATF7IP.Epidermis.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/colo/Epidermis.gml ...

  15. Prospects for toroidal fusion reactors

    International Nuclear Information System (INIS)

    Work on the International Thermonuclear Experimental Reactor (ITER) tokamak has refined understanding of the realities of a deuterium-tritium (D-T) burning magnetic fusion reactor. An ITER-like tokamak reactor using ITER costs and performance would lead to a cost of electricity (COE) of about 130 mills/kWh. Advanced tokamak physics to be tested in the Toroidal Physics Experiment (TPX), coupled with moderate components in engineering, technology, and unit costs, should lead to a COE comparable with best existing fission systems around 60 mills/kWh. However, a larger unit size, ∼2000 MW(e), is favored for the fusion system. Alternative toroidal configurations to the conventional tokamak, such as the stellarator, reversed-field pinch, and field-reversed configuration, offer some potential advantage, but are less well developed, and have their own challenges

  16. Induced toroid structures and toroid polarizabilities

    International Nuclear Information System (INIS)

    The frequency-dependent toroid dipole polarizability γ(ω) of a (nonrelativistic, spinless) hydrogen-like atom in its ground state is calculated analytically in terms of two Gauss hypergeometric functions. The static result reads simply γ(ω=0)=(23/60)α2Z-4a05 (α - fine structure constant, Z - nucleus charge number, a0 - Bohr radius). Comparing the present evaluations for H-like atoms with previous ones for pions, one sees that the role of the induced toroid moments (as against that of the usual electric ones) increases considerably when passing from atomic to particle physics

  17. A toroidal magnet option

    International Nuclear Information System (INIS)

    The possibility of using, for the ALICE forward muon spectrometer, a superconducting toroidal magnet has been considered in place of the SC dipole. The study has been restricted to the acceptance calculations and to the tracking simulations of the toroidal magnet but without technical investigations. The estimated performances are found maladjusted to the physics requirements of the heavy ion runs. (author)

  18. New Toroid shielding design

    CERN Multimedia

    Hedberg V

    On the 15th of June 2001 the EB approved a new conceptual design for the toroid shield. In the old design, shown in the left part of the figure above, the moderator part of the shielding (JTV) was situated both in the warm and cold areas of the forward toroid. It consisted both of rings of polyethylene and hundreds of blocks of polyethylene (or an epoxy resin) inside the toroid vacuum vessel. In the new design, shown to the right in the figure above, only the rings remain inside the toroid. To compensate for the loss of moderator in the toroid, the copper plug (JTT) has been reduced in radius so that a layer of borated polyethylene can be placed around it (see figure below). The new design gives significant cost-savings and is easier to produce in the tight time schedule of the forward toroid. Since the amount of copper is reduced the weight that has to be carried by the toroid is also reduced. Outgassing into the toroid vacuum was a potential problem in the old design and this is now avoided. The main ...

  19. Toroid magnet test facility

    CERN Multimedia

    2002-01-01

    Because of its exceptional size, it was not feasible to assemble and test the Barrel Toroid - made of eight coils - as an integrated toroid on the surface, prior to its final installation underground in LHC interaction point 1. It was therefore decided to test these eight coils individually in a dedicated test facility.

  20. A Superconducting Magnet Upgrade of the ATF2 Final Focus

    International Nuclear Information System (INIS)

    The ATF2 facility at KEK is a proving ground for linear collider technology with a well instrumented extracted beam line and Final Focus (FF). The primary ATF2 goal is to demonstrate the extreme beam demagnification and spot stability needed for a linear collider FF. But the ATF2 FF uses water cooled magnets and the ILC baseline has a superconducting (SC) FF. We plan to upgrade ATF2 and replace some of the warm FF magnets with SC FF magnets. The ATF2 SC magnets, like the ILC FF, will made via direct wind construction. ATF2 coil winding is in progress at BNL and warm magnetic measurements indicate we have achieved good field quality. Studies indicate that having ATF2 FF magnets with larger aperture and better field quality should allow reducing the ATF2 FF beta function for study of focusing regimes relevant to CLIC. The ATF2 magnet cryostat will have laser view ports for directly monitoring cold mass movement. We plan to make stability measurements at BNL and KEK to relate ATF2 FF magnet performance to that of a full length ILC QD0 R and D FF prototype under construction at BNL.

  1. Invisibility cloaks for toroids.

    Science.gov (United States)

    You, Yu; Kattawar, George W; Yang, Ping

    2009-04-13

    The material properties of toroidal invisibility cloaks are derived based on the coordinate transformation method. The permittivity and permeability tensors for toroidal cloaks are substantially different from those for spherical cloaks, but quite similar to those for 2D cylindrical cloaks because a singularity is involved at the inner boundary in both the cases. The cloaking effect is confirmed by the electric field distribution in the vicinity of toroidal cloaks simulated from the generalized discrete-dipole approximation (DDA) method. This study extends the concept of electromagnetic cloaking of arbitrarily-shaped objects to a complex geometry. PMID:19365485

  2. Analysis list: ATF4 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ATF4 Blood,Others + hg19 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/target/ATF...4.1.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/target/ATF4.5.tsv http://dbarchive.biosciencedbc.jp/...kyushu-u/hg19/target/ATF4.10.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/colo/ATF4.Blood.tsv,http://dbarchive.bioscience...dbc.jp/kyushu-u/hg19/colo/ATF4.Others.tsv http://dbarchive.bioscience...dbc.jp/kyushu-u/hg19/colo/Blood.gml,http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/colo/Others.gml ...

  3. Comparison of ATF and TJ-II stellarator equilibria as computed by the 3-D VMEC and PIES codes

    International Nuclear Information System (INIS)

    A comparison is made of results from the PIES code, which determines the equilibrium properties of three-dimensional toroidal configurations by direct integration along the magnetic field lines, with those from the VMEC code, which uses an energy minimization in a flux representation to determine the equilibrium configuration, for two devices: the ATF stellarator at Oak Ridge and the TJ-11 heliac which is being built in Madrid. The results obtained from the two codes are in good agreement, providing additional validation for the codes

  4. Studies of emittance growth in the ATF

    International Nuclear Information System (INIS)

    Several different mechanisms of emittance growth in the Accelerator Test Facility (ATF) at KEK are investigated: the author calculates rise times of the fast beam-ion instability for the damping ring (DR), and discusses the emittance growth caused by coherent synchrotron radiation in the beam-transport line (BT), the effect of quadrupole wake fields in the injector linac, and, finally, a single-bunch head-tail ion effect that can occur in both the DR and the BT. A first attempt to measure the quadrupole wake on the real machine is also reported

  5. Wire alignment system for ATF LINAC

    International Nuclear Information System (INIS)

    A wire based alignment system is adopted to make less than 40μm precision alignment for injector linac of Accelerator Test Facility (ATF). The system consists of two stretched SUS wires, pickup coils and active mover stages. The position of pickup coils in a mount which will be installed into LINAC stages is set to the calculated wire position prior to installation. All of LINAC stages are then moved to keep the calculated position by the active mover. The test results of wire position detection in a long term are described. (author)

  6. Fabrication Control Plan for ORNL RH-LOCA ATF Test Specimens to be Irradiated in the ATR

    Energy Technology Data Exchange (ETDEWEB)

    Kevin G. Field; Richard Howard; Michael Teague

    2014-06-01

    The purpose of this fabrication plan is (1) to summarize the design of a set of rodlets that will be fabricated and then irradiated in the Advanced Test Reactor (ATR) and (2) provide requirements for fabrication and acceptance criteria for inspections of the Light Water Reactor (LWR) – Accident Tolerant Fuels (ATF) rodlet components. The functional and operational (F&OR) requirements for the ATF program are identified in the ATF Test Plan. The scope of this document only covers fabrication and inspections of rodlet components detailed in drawings 604496 and 604497. It does not cover the assembly of these items to form a completed test irradiation assembly or the inspection of the final assembly, which will be included in a separate INL final test assembly specification/inspection document. The controls support the requirements that the test irradiations must be performed safely and that subsequent examinations must provide valid results.

  7. Approximations to toroidal harmonics

    International Nuclear Information System (INIS)

    Toroidal harmonics P/sub n-1/2/1(cosh μ) and Q/sub n-1/2/1(cosh μ) are useful in solutions to Maxwell's equations in toroidal coordinates. In order to speed their computation, a set of approximations has been developed that is valid over the range 0 -10. The simple method used to determine the approximations is described. Relative error curves are also presented, obtained by comparing approximations to the more accurate values computed by direct summation of the hypergeometric series

  8. Drift in toroidal configurations

    Science.gov (United States)

    Evangelidis, E. A.

    1990-12-01

    This paper considers possible mechanisms involved in amplifying the drift velocity of plasma particles, under conditions of toroidal geometry. It is shown that particles constrained to move on an axisymmetric circular spheroidal surface, develop a sinusoidal motion with a characteristic frequency which depends on the energy of the particles, the value of the isoflux surface, and the value of the general momentum. It is also shown that the incorporation of the effects of toroidal geometry in the Lorentz equation produces a nonambipolar charge-dependent particle flux amplified by a factor 2(q/epsilon) squared.

  9. ATF2 High Availability Power Supplies

    Energy Technology Data Exchange (ETDEWEB)

    Bellomo, A; Lira, C.de; Lam, B.; MacNair, D.; White, G.; /SLAC

    2008-06-27

    ATF2 is an accelerator test facility modeled after the final focus beamline envisioned for the ILC. By the end of 2008, KEK plans to commission the ATF2 [1]. SLAC and OCEM collaborated on the design of 38 power systems for beamline magnets. The systems range in output power from 1.5 kW to 6 kW. Since high availability is essential for the success of the ILC, Collaborators employed an N+1 modular approach, allowing for redundancy and the use of a single power module rating. This approach increases the availability of the power systems. Common power modules reduces inventory and eases maintenance. Current stability requirements are as tight as 10 ppm. A novel, SLAC designed 20-bit Ethernet Power Supply Controller provides the required precision current regulation. In this paper, Collaborators present the power system design, the expected reliability, fault immunity features, and the methods for satisfying the control and monitoring challenges. Presented are test results and the status of the power systems.

  10. Elongated toroid fusion device

    International Nuclear Information System (INIS)

    A device for achieving ignition of a plasma with ohmic heating is described comprising: means for defining a toroidal plasma chamber,a and confining gas therein, and means including electrically conductive coils for generating plasma within the chamber and for confining and shaping such plasma substantially into and filling a predetermined single region of the chamber without an axisymmetric internal separatix and ohmically heating the confined plasma to ignition. The predetermined region is toroidal with a major axis defining an axial direction parallel thereto and a transaxial direction perpendicular to the axis and having an axial cross section with an elongation, k, greater than 4, where k is the ratio of the maximum axial dimension of the cross section to the maximum transaxial dimension of the cross section

  11. Tokamak with liquid metal toroidal field coil

    Science.gov (United States)

    Ohkawa, Tihiro; Schaffer, Michael J.

    1981-01-01

    Tokamak apparatus includes a pressure vessel for defining a reservoir and confining liquid therein. A toroidal liner disposed within the pressure vessel defines a toroidal space within the liner. Liquid metal fills the reservoir outside said liner. Electric current is passed through the liquid metal over a conductive path linking the toroidal space to produce a toroidal magnetic field within the toroidal space about the major axis thereof. Toroidal plasma is developed within the toroidal space about the major axis thereof.

  12. Atf4 Regulates Obesity, Glucose Homeostasis, and Energy Expenditure

    OpenAIRE

    Seo, Jin; Fortuno, Edgardo S; Suh, Jae Myoung; Stenesen, Drew; Tang, Wei; Parks, Elizabeth J.; Adams, Christopher M.; Townes, Tim; Graff, Jonathan M.

    2009-01-01

    OBJECTIVE We evaluate a potential role of activating transcription factor 4 (Atf4) in invertebrate and mammalian metabolism. RESEARCH DESIGN AND METHODS With two parallel approaches—a fat body–specific green fluorescent protein enhancer trap screen in D. melanogaster and expression profiling of developing murine fat tissues—we identified Atf4 as expressed in invertebrate and vertebrate metabolic tissues. We assessed the functional relevance of the evolutionarily conserved expression by analyz...

  13. Observations on Tune and $\\beta$ Functions at the ATF Damping Ring

    CERN Document Server

    Potier, J P; Terunuma, N; Mimashi, T; Kubo, K; Korhonen, T T; Hayano, H; Okugi, T; Kashiwagi, S; Zimmermann, Frank

    1998-01-01

    The precise measurement of the transverse tunes and their spectra is a basic demand in accelerator commissioning. It provides a simple access to lattice characterisation and validation of the optical model. This contribution describes recent improvements of the tune monitor system at the Accelerator Test Facility Damping Ring (ATF-DR) and the performance achieved. We present preliminary measurement results of beta functions, chromaticity, and dispersion on a relaxed optics with 90 degree horizontal phase advance per cell and compare these with the theoretical predictions.

  14. Heating of toroidal plasmas

    International Nuclear Information System (INIS)

    The limitations of ohmic heating in achieving the thermonuclear ignition of a low-β toroidal plasma can be overcome by using several heating methods. Such methods are: fast neutral beam injection (possibly combined with an adiabatic compression or any other means) and HF heating, the most interesting schemes being based on plasma resonances. The basic physical phenomena in each method are briefly explained and results obtained are given. A new heating scheme using an outer frequency of a few kHz is described, that makes it possible to locate the exciting coils outside the vacuum vessel (some of these coils can be that producing the vertical magnetic field for the plasma equilibrium)

  15. Initial results from model independent analysis of the KEK ATF

    International Nuclear Information System (INIS)

    Model Independent Analysis (MIA) has shown the potential to be a useful tool for diagnostics and optics verification. The Accelerator Test Facility (ATF) prototype damping ring at KEK has a diagnostic system with the ability to collect data allowing the application of MIA for analysis of the injection stability, and the storage ring optics and diagnostics. Understanding of all these issues will be important for improving the operational performance of a damping ring. We report here the results of a first attempt to apply MIA to the ATF

  16. Drift waves in general toroidal geometry

    International Nuclear Information System (INIS)

    A model, based on gyro-kinetic ions and fluid electrons, to study drift waves in low-beta [beta = (kinetic pressure)/(magnetic pressure)] stellarator plasmas is presented. The model equations are written in straight-field-line coordinates and are valid for arbitrary, fully three-dimensional configurations with closed, nested magnetic surfaces. An implicit method, coupled with a subcycling technique for the electrons, is used to solve the time-dependent, along-the-field-line equations. Numerical calculations are carried out for a 3-field-period toroidal heliac. The geometrical effects that enter the model equations are calculated and displayed in physical space using advanced visualization techniques

  17. Toroidal Multipole Confinement Experiment

    International Nuclear Information System (INIS)

    Confinement of plasma is studied in the General Atomic toroidal octopole machine. The magnetic field is produced by four current carrying rings supported inside a contoured conductor. The rings are energized by a transformer core linking the machine. The major radius of the machine is 63.5 cm with an aspect ratio of 5. The magnetic field on the minor axis is zero and increases to 3500 G at the wall between the rings. After crowbarring, the field decays in 6 msec to its half value. The MHD stability calculation has been carried out and the stability is assured up to the plasma pressure of 1016 eV cm-3. Hydrogen plasmas from either a coaxial gun or a pinch gun with ion energies of 50 to 200 eV and with densities of 1014 cm-3 are successfully injected through a port located at the outer conductor wall. After the injection, plasma spreads azimuthally, filling the machine. Electric probes, magnetic probes, and calorimetric probes have been used extensively. Optical spectrometers and particle detectors are also used. The initial plasma density of 1013 cm-'3 decays with a time constant of 700 μsec. The electron temperature decays more quickly in about 100 μsec. No electric or magnetic fluctuations have been observed on any of the probes. Since no provision is made to avoid the plasma loss to the ring supports which penetrate the plasma region, the decay of ion temperature may be attributed to the support loss. (author)

  18. PEGASUS Toroidal Experimental Facility*

    Science.gov (United States)

    Lewicki, B.; Pegasus Group

    1998-11-01

    P EGASUS began operations in June 98 and will study the characteristics of Extremely Low-Aspect Ratio Tokamak (ELART) plasmas. The 2.0m diameter, thin-walled (6.35 mm) vacuum vessel is a continuous stainless steel shell with generous port access. Initial pump down base pressure was 5 × 10-8 torr. The high stress ohmic solenoid is powered by a 15 kV, 4.5 MJ capacitor bank and will be impedance-matched through a 10:1 step-down transformer to extend the pulse length. Operating at peak fields of 13 - 20 T, the solenoid can achieve a flux swing of up to 190mV-s over 60 ms. The toroidal field of 0.1 T on axis is powered by a 3 MVA AC/DC converter capable of 3.5 kA at 600 VDC. The equilibrium and shaping field magnets are powered by 2.2 F of commutated capacitor banks plus a 0.5 MVA programmable switching supply. Modest waveform control is available to compensate for the resistive vacuum vessel and aid in plasma shaping for elongated and diverted plasmas. Operational diagnostics include internal magnetic pickup loops, high resolution and fast framing cameras, and impurity monitoring systems. * *Supported by U.S. DoE grant No. DE-FG02-96ER54375

  19. Next generation toroidal devices

    International Nuclear Information System (INIS)

    A general survey of the possible approach for the next generation toroidal devices was made. Either surprisingly or obviously (depending on one's view), the technical constraints along with the scientific considerations lead to a fairly limited set of systems for the most favorable approach for the next generation devices. Specifically if the magnetic field strength of 5 T or above is to be created by superconducting coils, it imposes minimum in the aspect ratio for the tokamak which is slightly higher than contemplated now for ITER design. The similar technical constraints make the minimum linear size of a stellarator large. Scientifically, it is indicated that a tokamak of 1.5 times in the linear dimension should be able to produce economically, especially if a hybrid reactor is allowed. For the next stellarator, it is strongly suggested that some kind of helical axis is necessary both for the (almost) absolute confinement of high energy particles and high stability and equilibrium beta limits. The author still favors a heliac most. Although it may not have been clearly stated in the main text, the stability afforded by the shearless layer may be exploited fully in a stellarator. (author)

  20. Compact toroid formation experiments

    International Nuclear Information System (INIS)

    We present the design and experimental performance of a compact toroid (CT) formation experiment. The device has co-axial electrode diameters of 0.9 m (inner) and 1.25 m (outer), and an electrode length of ∼ 1.2 m, including an expansion/drift section. The CT is formed by a 0.1--0.2 Tesla initial radial magnetic field embedded co-axial puff gas discharge. The gas puff is injected with an array of 60 pulsed solenoid driven fast valves. The formation discharge is driven by a 108 microfarad, 40 to 100 KV, 86 to 540 kilojoule 2 to 5 megamp capacitor discharge with ∼ 20 nanohenry initial total discharge inductance. The hardware includes transmission line connections for a Shiva Star (1300 microfarad, up to 120 KV, 0.4 megajoule) capacitor bank driven acceleration discharge. Experimental measurements include current, voltage; azimuthal, radial and axial magnetic field at numerous location; fast photography, optical spectroscopy; microwave, CO2 laser, and He-Ne laser interferometry. Auxiliary experiments include Penning ionization gauge, pressure probe, and breakdown gas trigger diagnostics of gas injection, and Hall probe measurements of magnetic field injection

  1. SR monitor system for the ATF Damping Ring

    International Nuclear Information System (INIS)

    Preliminary results of the synchrotron radiation (SR) monitor system developed for the Damping Ring of the accelerator test facility in Tsukuba-KEK (KEK-ATF-DR) are described; The system consists of a two dimensional CCD camera and a double-sweep streak camera for observing the vertical and longitudinal shapes of bunched beams, respectively. (author)

  2. Human CHAC1 Protein Degrades Glutathione, and mRNA Induction Is Regulated by the Transcription Factors ATF4 and ATF3 and a Bipartite ATF/CRE Regulatory Element*

    Science.gov (United States)

    Crawford, Rebecca R.; Prescott, Eugenia T.; Sylvester, Charity F.; Higdon, Ashlee N.; Shan, Jixiu; Kilberg, Michael S.; Mungrue, Imran N.

    2015-01-01

    Using an unbiased systems genetics approach, we previously predicted a role for CHAC1 in the endoplasmic reticulum stress pathway, linked functionally to activating transcription factor 4 (ATF4) following treatment with oxidized phospholipids, a model for atherosclerosis. Mouse and yeast CHAC1 homologs have been shown to degrade glutathione in yeast and a cell-free system. In this report, we further defined the ATF4-CHAC1 interaction by cloning the human CHAC1 promoter upstream of a luciferase reporter system for in vitro assays in HEK293 and U2OS cells. Mutation and deletion analyses defined two major cis DNA elements necessary and sufficient for CHAC1 promoter-driven luciferase transcription under conditions of ER stress or ATF4 coexpression: the −267 ATF/cAMP response element (CRE) site and a novel −248 ATF/CRE modifier (ACM) element. We also examined the ability of the CHAC1 ATF/CRE and ACM sequences to bind ATF4 and ATF3 using immunoblot-EMSA and confirmed ATF4, ATF3, and CCAAT/enhancer-binding protein β binding at the human CHAC1 promoter in the proximity of the ATF/CRE and ACM using ChIP. To further validate the function of CHAC1 in a human cell model, we measured glutathione levels in HEK293 cells with enhanced CHAC1 expression. Overexpression of CHAC1 led to a robust depletion of glutathione, which was alleviated in a CHAC1 catalytic mutant. These results suggest an important role for CHAC1 in oxidative stress and apoptosis with implications for human health and disease. PMID:25931127

  3. Human CHAC1 Protein Degrades Glutathione, and mRNA Induction Is Regulated by the Transcription Factors ATF4 and ATF3 and a Bipartite ATF/CRE Regulatory Element.

    Science.gov (United States)

    Crawford, Rebecca R; Prescott, Eugenia T; Sylvester, Charity F; Higdon, Ashlee N; Shan, Jixiu; Kilberg, Michael S; Mungrue, Imran N

    2015-06-19

    Using an unbiased systems genetics approach, we previously predicted a role for CHAC1 in the endoplasmic reticulum stress pathway, linked functionally to activating transcription factor 4 (ATF4) following treatment with oxidized phospholipids, a model for atherosclerosis. Mouse and yeast CHAC1 homologs have been shown to degrade glutathione in yeast and a cell-free system. In this report, we further defined the ATF4-CHAC1 interaction by cloning the human CHAC1 promoter upstream of a luciferase reporter system for in vitro assays in HEK293 and U2OS cells. Mutation and deletion analyses defined two major cis DNA elements necessary and sufficient for CHAC1 promoter-driven luciferase transcription under conditions of ER stress or ATF4 coexpression: the -267 ATF/cAMP response element (CRE) site and a novel -248 ATF/CRE modifier (ACM) element. We also examined the ability of the CHAC1 ATF/CRE and ACM sequences to bind ATF4 and ATF3 using immunoblot-EMSA and confirmed ATF4, ATF3, and CCAAT/enhancer-binding protein β binding at the human CHAC1 promoter in the proximity of the ATF/CRE and ACM using ChIP. To further validate the function of CHAC1 in a human cell model, we measured glutathione levels in HEK293 cells with enhanced CHAC1 expression. Overexpression of CHAC1 led to a robust depletion of glutathione, which was alleviated in a CHAC1 catalytic mutant. These results suggest an important role for CHAC1 in oxidative stress and apoptosis with implications for human health and disease. PMID:25931127

  4. Ceapins inhibit ATF6α signaling by selectively preventing transport of ATF6α to the Golgi apparatus during ER stress

    Science.gov (United States)

    Gallagher, Ciara M; Walter, Peter

    2016-01-01

    The membrane-bound transcription factor ATF6α is activated by proteolysis during endoplasmic reticulum (ER) stress. ATF6α target genes encode foldases, chaperones, and lipid biosynthesis enzymes that increase protein-folding capacity in response to demand. The off-state of ATF6α is maintained by its spatial separation in the ER from Golgi-resident proteases that activate it. ER stress induces trafficking of ATF6α. We discovered Ceapins, a class of pyrazole amides, as selective inhibitors of ATF6α signaling that do not inhibit the Golgi proteases or other UPR branches. We show that Ceapins block ATF6α signaling by trapping it in ER-resident foci that are excluded from ER exit sites. Removing the requirement for trafficking by pharmacological elimination of the spatial separation of the ER and Golgi apparatus restored cleavage of ATF6α in the presence of Ceapins. Washout of Ceapins resensitized ATF6α to ER stress. These results suggest that trafficking of ATF6α is regulated by its oligomeric state. DOI: http://dx.doi.org/10.7554/eLife.11880.001

  5. Role of ATF5 in the invasive potential of diverse human cancer cell lines.

    Science.gov (United States)

    Nukuda, Akihiro; Endoh, Hiroki; Yasuda, Motoaki; Mizutani, Takeomi; Kawabata, Kazushige; Haga, Hisashi

    2016-06-01

    Activating transcription factor 5 (ATF5) is a member of the ATF/cAMP response element-binding protein family. Our research group recently revealed that ATF5 expression increases the invasiveness of human lung carcinoma cells. However, the effects of ATF5 on the invasive potential of other cancer cells lines remain unclear. Therefore, in this study, we investigated the role of ATF5 in the invasive activity of diverse human cancer cell lines. Invasiveness was assessed using Matrigel invasion assays. ATF5 knockdown resulted in decreased invasiveness in seven of eight cancer cell lines tested. These results suggest that ATF5 promotes invasiveness in several cancer cell lines. Furthermore, the roles of ATF5 in the invasiveness were evaluated in three-dimensional (3D) culture conditions. In 3D collagen gel, HT-1080 and MDA-MB-231 cells exhibited high invasiveness, with spindle morphology and high invasion speed. In both cell lines, knockdown of ATF5 resulted in rounded morphology and decreased invasion speed. Next, we showed that ATF5 induced integrin-α2 and integrin-β1 expression and that the depletion of integrin-α2 or integrin-β1 resulted in round morphology and decreased invasion speed. Our results suggest that ATF5 promotes invasion by inducing the expression of integrin-α2 and integrin-β1 in several human cancer cell lines. PMID:27125458

  6. Compact toroid theory issues and approaches: a panel report

    International Nuclear Information System (INIS)

    In the six years since the initiation of the compact toroid program by the Office of Fusion Energy, remarkable scientific advances have occurred on both field-reversed configurations (FRC) and spheromaks. This progress has been stimulated by a diverse experimental program with facilities at six laboratories, and by a small but nevertheless broad theoretical research effort encompassing more than a dozen institutions. The close coupling between theoretical and experimental programs has contributed immeasurably to this progress. This document offers guidance for future compact toroid theory by identifying and discussing the key physics issues. In most cases promising approaches to these issues are offered

  7. Active toroidal field ripple reduction system in FAST

    International Nuclear Information System (INIS)

    The fusion advanced studies torus (FAST) has been proposed as a flexible and cost effective machine that is able to support the development of ITER and DEMO operating scenarios exploiting some innovative technology solutions and to investigate the physics of high-performance plasmas in a dimensionless parameter range close to ITER. The FAST magnet consists of 18 coils, spaced by 20o in the toroidal angle, each made up of 14 copper plates, suitably arranged in order to realise 3 turns in the radial direction, with 89.2 kA per coil (in the H-mode plasma scenario 6.5 MA at 7.5 T). The finite number and toroidal extension of the toroidal field coils (TFCs) cause a periodic variation of the toroidal field from its nominal value called toroidal field ripple (TFR). An active ripple reduction system has been comprehensively investigated, by using proper 3D finite elements models, to provide an efficient and flexible system able to minimize the TFR in the region of interest. An optimization study of position and size of the coils required to reduce to an acceptable level for the operations the maximum ripple on the plasma (well below 0.3%), feeding them with currents sustainable during the whole scenario (∼1/10 of the current flowing in TFCs), is presented in this paper.

  8. Heavy ion toroidal collective accelerator

    International Nuclear Information System (INIS)

    Experiments on HIPAC at Maxwell Laboratories have shown that almost all of the confined electrons are trapped and do not go around the torus. A toroidal electric field produces a negligible toroidal electron current. An ion accelerator where electrons are magnetically contained and their space charge contains ions is considered. A toroidal electric field of suitable magnitude can be applied so that it accelerates all of the ions but does not accelerate most of the electrons. This is possible if the magnetic moment of electrons μsub(e) > μsub(i)/Z, where μsub(i) is the ion magnetic moment and Z is the charge of the ion. Ions would be contained by the electron space-charge electric field E, for energies up to ZeER/2 approximately 100 GeV where Z = 60, E = 107 V/cm and the major radius of the torus is R = 3.3 metres. (author)

  9. RF breakdown by toroidal helicons

    Indian Academy of Sciences (India)

    S K P Tripathi; D Bora; M Mishra

    2001-04-01

    Bounded whistlers are well-known for their efficient plasma production capabilities in thin cylindrical tubes. In this paper we shall present their radio frequency (RF) breakdown and discharge sustaining capabilities in toroidal systems. Pulsed RF power in the electronmagnetohydrodynamic (EMHD) frequency regime is fed to the neutral background medium. After the breakdown stage, discharge is sustained by toroidal bounded whistlers. In these pulsed experiments the behaviour of the time evolution of the discharge could be studied in four distinct phases of RF breakdown, steady state attainment, decay and afterglow. In the steady state average electron density of ≈ 1012 per cc and average electron temperature of ≈ 20 eV are obtained at 10-3 mbar of argon filling pressure. Experimental results on toroidal mode structure, background effects and time evolution of the electron distribution function will be presented and their implications in understanding the breakdown mechanism are discussed.

  10. Hybrid winding concept for toroids

    DEFF Research Database (Denmark)

    Schneider, Henrik; Andersen, Thomas; Knott, Arnold;

    2013-01-01

    This paper proposes a hybrid winding concept for toroids using the traces in a printed circuit board to make connection to bended copper foil cutouts. In a final product a number of strips with a certain thickness would be held by a former and the whole assembly could be placed by pick and...... placement machinery. This opens up the possibility for both an automated manufacturing process and an automated production process of toroidal magnetics such as power inductors, filtering inductors, air core inductors, transformers etc. Both the proposed hybrid and the common wire wound winding...

  11. The complex and unique ATLAS Toroid family

    CERN Multimedia

    2002-01-01

    Big parts for the toroid magnets that will be used in the ATLAS experiment have been continuously arriving at CERN since March. These structures will create the largest superconducting toroid magnet ever.

  12. Cavity Beam Position Monitor System for ATF2

    Energy Technology Data Exchange (ETDEWEB)

    Boogert, Stewart; /Oxford U., JAI; Boorman, Gary; /Oxford U., JAI; Swinson, Christina; /Oxford U., JAI; Ainsworth, Robert; /Royal Holloway, U. of London; Molloy, Stephen; /Royal Holloway, U. of London; Aryshev, Alexander; /KEK, Tsukuba; Honda, Yosuke; /KEK, Tsukuba; Tauchi, Toshiaki; /KEK, Tsukuba; Terunuma, Nobuhiro; /KEK, Tsukuba; Urakawa, Junji; /KEK, Tsukuba; Frisch, Josef; /SLAC; May, Justin; /SLAC; McCormick, Douglas; /SLAC; Nelson, Janice; /SLAC; Smith, Tonee; /SLAC; White, Glen; /SLAC; Woodley, Mark; /SLAC; Heo, Ae-young; /Kyungpook Natl. U.; Kim, Eun-San; /Kyungpook Natl. U.; Kim, Hyoung-Suk; /Kyungpook Natl. U.; Kim, Youngim; /Kyungpook Natl. U. /University Coll. London /Kyungpook Natl. U. /Fermilab /Pohang Accelerator Lab.

    2012-07-09

    The Accelerator Test Facility 2 (ATF2) in KEK, Japan, is a prototype scaled demonstrator system for the final focus required for a future high energy lepton linear collider. The ATF2 beam-line is instrumented with a total of 38 C and S band resonant cavity beam position monitors (CBPM) with associated mixer electronics and digitizers. The current status of the BPM system is described, with a focus on operational techniques and performance. The ATF2 C-band system is performing well, with individual CBPM resolution approaching or at the design resolution of 50 nm. The changes in the CBPM calibration observed over three weeks can probably be attributed to thermal effects on the mixer electronics systems. The CW calibration tone power will be upgraded to monitor changes in the electronics gain and phase. The four S-band CBPMs are still to be investigated, the main problem associated with these cavities is a large cross coupling between the x and y ports. This combined with the large design dispersion in that degion makes the digital signal processing difficult, although various techniques exist to determine the cavity parameters and use these coupled signals for beam position determination.

  13. Study of Abnormal Vertical Emittance Growth in ATF Extraction Line

    Energy Technology Data Exchange (ETDEWEB)

    Alabau, M.; Faus-Golfe, A.; /Valencia U., IFIC; Alabau, M.; Bambade, P.; Brossard, J.; Le Meur, G.; Rimbault, C.; Touze, F.; /Orsay, LAL; Angal-Kalinin, D.; Jones, J.K.; /Daresbury; Appleby, R.; Scarfe, A.; /Manchester U.; Kuroda, S.; /KEK, Tsukuba; White, G.R.; Woodley, M.; /SLAC; Zimmermann, F.; /CERN

    2011-11-04

    Since several years, the vertical beam emittance measured in the Extraction Line (EXT) of the Accelerator Test Facility (ATF) at KEK, that will transport the electron beam from the ATF Damping Ring (DR) to the future ATF2 Final Focus beam line, is significantly larger than the emittance measured in the DR itself, and there are indications that it grows rapidly with increasing beam intensity. This longstanding problem has motivated studies of possible sources of this anomalous emittance growth. One possible contribution is non-linear magnetic fields in the extraction region experimented by the beam while passing off-axis through magnets of the DR during the extraction process. In this paper, simulations of the emittance growth are presented and compared to observations. These simulations include the effects of predicted non-linear field errors in the shared DR magnets and orbit displacements from the reference orbit in the extraction region. Results of recent measurements using closed orbit bumps to probe the relation between the extraction trajectory and the anomalous emittance growth are also presented.

  14. Intrinsic rotation of toroidally confined magnetohydrodynamics

    OpenAIRE

    Morales, Jorge; Bos, Wouter; Schneider, Kai; Montgomery, David

    2012-01-01

    The spatiotemporal self-organization of viscoresistive magnetohydrodynamics (MHD) in a toroidal geometry is studied. Curl-free toroidal magnetic and electric fields are imposed. It is observed in our simulations that a flow is generated, which evolves from dominantly poloidal to toroidal when the Lundquist numbers are increased. It is shown that this toroidal organization of the flow is consistent with the tendency of the velocity field to align with the magnetic field. Up-down asymmetry of t...

  15. ATF4 is involved in the regulation of simulated microgravity induced integrated stress response

    Science.gov (United States)

    Li, Yingxian; Li, Qi; Wang, Xiaogang; Sun, Qiao; Wan, Yumin; Li, Yinghui; Bai, Yanqiang

    Objective: Many important metabolic and signaling pathways have been identified as being affected by microgravity, thereby altering cellular functions such as proliferation, differentiation, maturation and cell survival. It has been demonstrated that microgravity could induce all kinds of stress response such as endoplasmic reticulum stress and oxidative stress et al. ATF4 belongs to the ATF/CREB family of basic region leucine zipper transcription factors. ATF4 is induced by stress signals including anoxia/hypoxia, ER stress, amino acid deprivation and oxidative stress. ATF4 regulates the expression of genes involved in oxidative stress, amino acid synthesis, differentiation, metastasis and angiogenesis. The aim of this study was to examine the changes of ATF4 under microgravity, and to investigate the role of ATF4 in microgravity induced stress. MethodsMEF cells were cultured in clinostat to simulate microgravity. Reverse transcription polymerase chain reaction (RT-PCR) and western blotting were used to examine mRNA and protein levels of ATF4 expression under simulated microgravity in MEF cells. ROS levels were measured with the use of the fluorescent signal H2DCF-DA. GFP-XBP1 stably transfected cell lines was used to detect the extent of ER stress under microgravity by the intensity of GFP. Dual luciferase reporter assay was used to detect the activity of ATF4. Co-immunoprecipitation was performed to analyze protein interaction. Results: ATF4 protein levels in MEF cells increased under simulated microgravity. However, ATF4 mRNA levels were consistent. XBP1 splicing can be induced due to ER stress caused by simulated microgravity. At the same time, ROS levels were also increased. Increased ATF4 could promote the expression of CHOP, which is responsible for cell apoptosis. ATF4 also play an important role in cellular anti-oxidant stress. In ATF4 -/-MEF cells, the ROS levels after H2O2 treatment were obviously higher than that of wild type cells. HDAC4 was

  16. Technology of toroidal plasma devices

    International Nuclear Information System (INIS)

    After research into many different magnetic confinement systems, there is now general agreement that the most favorable ones for future fusion reactors are all based on toroidal geometry, as distinct from having open ends like mirror machines. For this reason plasma physics research, even when not aimed directly at the fusion problems, has in recent years increasingly concentrated on toroidal systems. One reason is that by using their good confinement properties the experimenter has available a range of high temperature plasma parameters in quasisteady (or even steady) state conditions not otherwise available on Earth. Despite the wide variety of both geometrical possibilities and sizes, ranging from table-top experiments with plasmas a few centimetres across to near reactor scale ones like JET with plasmas several metres across, toroidal systems have many common features, both in their physical principles and of experimental design: the purpose of this paper is to highlight those common features, using some specific examples for illustration, and emphasizing some of the more practical aspects. It will also try to point out important differences between two of the main classes of toroidal systems

  17. ATLAS superconducting toroids and solenoid

    CERN Document Server

    ten Kate, H H J

    2005-01-01

    The ATLAS particle detector in the Large Hadron Collider at CERN features a hybrid system of four superconducting magnets: a Central Solenoid surrounded by 2 End-cap Toroids and a Barrel Toroid. The magnet system dimensions are 20 m in diameter and 26 m in length. With its 1.55 GJ stored energy in air, it actually is the largest superconducting magnet in the world. The construction of the magnets has started in 1998 and will end in 2006 with the completion of the installation underground. Currently, in October 2004, practically all magnet parts are manufactured and delivered to CERN for final integration. The first two out of 8 full size 25*5 m/sup 2/ size coils for the Barrel Toroid have been completed and tested while the other 6 are near to completion as well. The production of the so- called End-Cap Toroids is progressing well. The Central Solenoid is complete and ready for installation. The installation underground of the entire system including its services has commenced. In the paper the main features ...

  18. The upgraded Pegasus Toroidal Experiment

    International Nuclear Information System (INIS)

    The Pegasus Toroidal Experiment was developed to explore the physics limits of plasma operation as the aspect ratio (A) approaches unity. Initial experiments on the device found that access to high normalized current and toroidal beta was limited by the presence of large-scale tearing modes. Major upgrades have been conducted of the facility to provide the control tools necessary to mitigate these resistive modes. The upgrades include new programmable power supplies, new poloidal field coils and increased, time-variable toroidal field. First ohmic operations with the upgraded system demonstrated position and current ramp-rate control, as well as improvement in ohmic flux consumption from 2.9 MA Wb-1 to 4.2 MA Wb-1. The upgraded experiment will be used to address three areas of physics interest. First, the kink and ballooning stability boundaries at low A and high normalized current will be investigated. Second, clean, high-current plasma sources will be studied as a helicity injection tool. Experiments with two such sources have produced toroidal currents three times greater than predicted by geometric field line following. Finally, the use of electron Bernstein waves to heat and drive current locally will be studied at the 1 MW level; initial modelling indicates that these experiments are feasible at a frequency of 2.45 GHz

  19. Lowering the first ATLAS toroid

    CERN Multimedia

    Maximilien Brice

    2004-01-01

    The ATLAS detector on the LHC at CERN will consist of eight toroid magnets, the first of which was lowered into the cavern in these images on 26 October 2004. The coils are supported on platforms where they will be attached to form a giant torus. The platforms will hold about 300 tonnes of ATLAS' muon chambers and will envelop the inner detectors.

  20. Toroidal solutions in Horava Gravity

    OpenAIRE

    Ghodsi, Ahmad

    2009-01-01

    Recently a new four-dimensional non relativistic renormalizable theory of gravity was proposed by Horava. This gravity reduces to Einstein gravity at large distances. In this paper by using the new action for gravity we present different toroidal solutions to the equations of motion. Our solutions describe the near horizon geometry with slow rotating parameter.

  1. Onsager relaxation of toroidal plasmas

    International Nuclear Information System (INIS)

    The slow relaxation of isolated toroidal plasmas towards their thermodynamical equilibrium is studied in an Onsager framework based on the entropy metric. The basic tool is a variational principle, equivalent to the kinetic equation, involving the profiles of density, temperature, electric potential, electric current. New minimization procedures are proposed to obtain entropy and entropy production rate functionals. (author)

  2. Extremely high Q-factor toroidal metamaterials

    CERN Document Server

    Basharin, Alexey A; Volsky, Nikita; Kafesaki, Maria; Economou, Eleftherios N; Ustinov, Alexey V

    2016-01-01

    We demonstrate that, owing to the unique topology of the toroidal dipolar mode, its electric/magnetic field can be spatially confined within subwavelength, externally accessible regions of the metamolecules, which makes the toroidal planar metamaterials a viable platform for high Q-factor resonators due to interfering toroidal and other dipolar modes in metamolecules.

  3. ATLAS End Cap toroid in upstanding position

    CERN Multimedia

    2005-01-01

    End Cap toroid The ATLAS End Cap toroid weights 240-ton and is 12-m diameter high. The parts of this vacuum vessel had to be integrated and tested so that End Cap Toroid has no leaks. After that it could be cooled down to 80 K.

  4. A key role for ATF3 in regulating mast cell survival and mediator release

    OpenAIRE

    Gilchrist, Mark; Henderson, William R.; Morotti, Andrew; Carrie D. Johnson; Nachman, Alex; Schmitz, Frank; Smith, Kelly D.; Aderem, Alan

    2010-01-01

    Activating transcription factor 3 (ATF3) is a basic leucine zipper transcription factor that plays a regulatory role in inflammation, cell division, and apoptosis. Mast cells (MCs) initiate many inflammatory responses and have a central role in allergy and allergic diseases. We report here that ATF3 has a central role in MC development and function. Bone marrow–derived MC populations from ATF3-deficient mice are unresponsive to interleukin-3 (IL-3)–induced maturation signals, and this correla...

  5. Improved antibody production in Chinese hamster ovary cells by ATF4 overexpression

    OpenAIRE

    Haredy, Ahmad M.; Nishizawa, Akitoshi; Honda, Kohsuke; Ohya, Tomoshi; Ohtake, Hisao; Omasa, Takeshi

    2013-01-01

    To improve antibody production in Chinese hamster ovary (CHO) cells, the humanized antibody-producing CHO DP-12-SF cell line was transfected with the gene encoding activating transcription factor 4 (ATF4), a central factor in the unfolded protein response. Overexpression of ATF4 significantly enhanced the production of antibody in the CHO DP-12-SF cell line. The specific IgG production rate of in the ATF4-overexpressing CHO-ATF4-16 cells was approximately 2.4 times that of the parental host c...

  6. ATF3 inhibits adipocyte differentiation of 3T3-L1 cells

    Energy Technology Data Exchange (ETDEWEB)

    Jang, Min Kyung; Kim, Cho Hee [School of Korean Medicine, Pusan National University, 30 Beom-eo ri, Mulguem-eup, Yangsan-si, Gyeongnam 609-735 (Korea, Republic of); Seong, Je Kyung [Department of Anatomy and Cell Biology, College of Veterinary Medicine, Seoul National University, Seoul 151-742 (Korea, Republic of); Jung, Myeong Ho, E-mail: jung0603@pusan.ac.kr [School of Korean Medicine, Pusan National University, 30 Beom-eo ri, Mulguem-eup, Yangsan-si, Gyeongnam 609-735 (Korea, Republic of)

    2012-04-27

    Highlights: Black-Right-Pointing-Pointer Overexpression of ATF3 inhibits adipocyte differentiation in 3T3-L1 cells. Black-Right-Pointing-Pointer Overexpression of ATF3 represses C/EBP{alpha} expression. Black-Right-Pointing-Pointer ATF3 directly binds to mouse C/EBP{alpha} promoter spanning from -1928 to -1907. Black-Right-Pointing-Pointer ATF3 may play a role in hypoxia-mediated inhibition of adipocyte differentiation. -- Abstract: ATF3 is a stress-adaptive gene that regulates proliferation or apoptosis under stress conditions. However, the role of ATF3 is unknown in adipocyte cells. Therefore, in this study, we investigated the functional role of ATF3 in adipocytes. Both lentivirus-mediated overexpression of ATF3 and stably-overexpressed ATF3 inhibited adipocyte differentiation in 3T3-L1 cells, as revealed by decreased lipid staining with oil red staining and reduction in adipogenic genes. Thapsigargin treatment and overexpression of ATF3 decreased C/EBP{alpha} transcript and repressed the activity of the 3.6-kb mouse C/EBP{alpha} promoter, demonstrating that ATF3 downregulates C/EBP{alpha} expression. Transfection studies using mutant constructs containing 5 Prime -deletions in the C/EBP{alpha} promoter revealed that a putative ATF/CRE element, GGATGTCA, is located between -1921 and -1914. Electrophoretic mobility shift assay and chromatin immunoprecipitation assay demonstrated that ATF3 directly binds to mouse C/EBP{alpha} promoter spanning from -1928 to -1907. Both chemical hypoxia-mimetics or physical hypoxia led to reduce the C/EBP{alpha} mRNA and repress the promoter activity of the C/EBP{alpha} gene, whereas increase ATF3 mRNA, suggesting that ATF3 may contribute to the inhibition of adipocyte differentiation in hypoxia through downregulation of C/EBP{alpha} expression. Collectively, these results demonstrate that ATF3 represses the C/EBP{alpha} gene, resulting in inhibition of adipocyte differentiation, and thus plays a role in hypoxia-mediated inhibition

  7. Glucose deprivation induces chemoresistance in colorectal cancer cells by increasing ATF4 expression

    Science.gov (United States)

    Hu, Ya-Ling; Yin, Yuan; Liu, He-Yong; Feng, Yu-Yang; Bian, Ze-Hua; Zhou, Le-Yuan; Zhang, Ji-Wei; Fei, Bo-Jian; Wang, Yu-Gang; Huang, Zhao-Hui

    2016-01-01

    AIM: To investigate the role of activating transcription factor 4 (ATF4) in glucose deprivation (GD) induced colorectal cancer (CRC) drug resistance and the mechanism involved. METHODS: Chemosensitivity and apoptosis were measured under the GD condition. Inhibition of ATF4 using short hairpin RNA in CRC cells under the GD condition and in ATF4-overexpressing CRC cells was performed to identify the role of ATF4 in the GD induced chemoresistance. Quantitative real-time RT-PCR and Western blot were used to detect the mRNA and protein expression of drug resistance gene 1 (MDR1), respectively. RESULTS: GD protected CRC cells from drug-induced apoptosis (oxaliplatin and 5-fluorouracil) and induced the expression of ATF4, a key gene of the unfolded protein response. Depletion of ATF4 in CRC cells under the GD condition can induce apoptosis and drug re-sensitization. Similarly, inhibition of ATF4 in the ATF4-overexpressing CRC cells reintroduced therapeutic sensitivity and apoptosis. In addition, increased MDR1 expression was observed in GD-treated CRC cells. CONCLUSION: These data indicate that GD promotes chemoresistance in CRC cells through up-regulating ATF4 expression. PMID:27468213

  8. Intrinsic rotation of toroidally confined magnetohydrodynamics.

    Science.gov (United States)

    Morales, Jorge A; Bos, Wouter J T; Schneider, Kai; Montgomery, David C

    2012-10-26

    The spatiotemporal self-organization of viscoresistive magnetohydrodynamics in a toroidal geometry is studied. Curl-free toroidal magnetic and electric fields are imposed. It is observed in our simulations that a flow is generated, which evolves from dominantly poloidal to toroidal when the Lundquist numbers are increased. It is shown that this toroidal organization of the flow is consistent with the tendency of the velocity field to align with the magnetic field. Up-down asymmetry of the geometry causes the generation of a nonzero toroidal angular momentum. PMID:23215195

  9. Nonideal magnetohydrodynamic instabilities and toroidal magnetic confinement

    International Nuclear Information System (INIS)

    The marked divergence of experimentally observed plasma instability phenomena from the predictions of ideal magnetohydrodynamics led in the early 1960s to the formulations of finite-resistivity stability theory. Beginning in the 1970s, advanced plasma diagnostics have served to establish a detailed correspondence between the predictions of the finite-resistivity theory and experimental plasma behavior - particularly in the case of the resistive kink mode and the tokamak plasma. Nonlinear resistive-kink phenomena have been found to govern the transport of magnetic flux and plasma energy in the reversed-field pinch. The other predicted finite-resistivity instability modes have been more difficult to identify directly and their implications for toroidal magnetic confinement are still unresolved

  10. Nonideal magnetohydrodynamic instabilities and toroidal magnetic confinement

    Energy Technology Data Exchange (ETDEWEB)

    Furth, H.P.

    1985-05-01

    The marked divergence of experimentally observed plasma instability phenomena from the predictions of ideal magnetohydrodynamics led in the early 1960s to the formulations of finite-resistivity stability theory. Beginning in the 1970s, advanced plasma diagnostics have served to establish a detailed correspondence between the predictions of the finite-resistivity theory and experimental plasma behavior - particularly in the case of the resistive kink mode and the tokamak plasma. Nonlinear resistive-kink phenomena have been found to govern the transport of magnetic flux and plasma energy in the reversed-field pinch. The other predicted finite-resistivity instability modes have been more difficult to identify directly and their implications for toroidal magnetic confinement are still unresolved.

  11. Fluid interaction with spinning toroidal tanks

    Science.gov (United States)

    Fester, D. A.; Anderson, J. E.

    1977-01-01

    An experimental study was conducted to evaluate propellant behavior in spinning torroidal tanks that could be used in a retropropulsion system of an advanced outer-planet Pioneer orbiter. Information on propellant slosh and settling and on ullage orientation and stability was obtained. The effects of axial acceleration, spin rate, spin-rate change, and spacecraft wobble, both singly and in combination, were evaluated using a one-eighth scale transparent tank in one-g and low-g environments. Liquid loadings ranged from 5% to 96% full. The impact of a surface tension acquisition device was assessed by comparison with bare-tank results. The testing simulated the behavior of the fluorine/hydrazine and nitrogen textroxide/monomethylhydrazine propellants. Results are presented that indicate that no major fluid behavior problems would be encountered with any of the four propellants in the toroidal tanks of a spin-stabilized orbiter spacecraft.

  12. Design and Simulation of Toroidal Twister Model

    Institute of Scientific and Technical Information of China (English)

    TIAN Huifang; LIN Xizhen; ZENG Qinqin

    2006-01-01

    Toroidal composite vessel winded with fiber is a new kind of structural pressure vessels, which not only has high structure efficiency of compound materials pressure vessel, good security and so on, but also has special shape and the property of utilizing toroidal space, and the prospect of the application of toroidal composite vessel winded with fiber is extremely broad. By introducing parameters establishment of toroidal vessel and elaborating the principle of filament winding for toroidal vessel, the design model of filament winding machine for toroidal vessel has been introduced, and the design model has been dynamically simulated by the software of ADAMS, which will give more referrence for the design of real toroidal vessel twister.

  13. Cadmium interferes with the degradation of ATF5 via a post-ubiquitination step of the proteasome degradation pathway

    International Nuclear Information System (INIS)

    ATF5 is a member of the CREB/ATF family of transcription factors. In the current study, using a transient transfection system to express FLAG epitope fusion proteins of ATF5, we have shown that CdCl2 or NaAsO3 increases the protein levels of ATF5 in cells, and that cadmium stabilizes the ATF5 protein. Proteasome inhibitors had a similar effect to cadmium on the cellular accumulation of ATF5. Proteasome inhibition led to an increase in ubiquitinated ATF5, while cadmium did not appear to reduce the extent of ATF5 ubiquitination. ATF5 contains a putative nuclear export signal within its N-terminus. We demonstrated that whereas deletion of N-terminal region resulted in a increase of ATF5 levels, this region does not appear to be involved in the ubiquitination of ATF5. These results indicate that ATF5 is targeted for degradation by the ubiquitin-proteasome pathway, and that cadmium slows the rate of ATF5 degradation via a post-ubiquitination mechanism.

  14. TFTR toroidal field coil design

    International Nuclear Information System (INIS)

    The design of the Tokamak Fusion Test Reactor (TFTR) Toroidal Field (TF) magnetic coils is described. The TF coil is a 44-turn, spiral-wound, two-pancake, water-cooled configuration which, at a coil current of 73.3 kiloamperes, produces a 5.2-Tesla field at a major radius of 2.48 meters. The magnetic coils are installed in titanium cases, which transmit the loads generated in the coils to the adjacent supporting structure. The TFTR utilizes 20 of these coils, positioned radially at 180 intervals, to provide the required toroidal field. Because it is very highly loaded and subject to tight volume constraints within the machine, the coil presents unique design problems. The TF coil requirements are summarized, the coil configuration is described, and the problems highlighted which have been encountered thus far in the coil design effort, together with the development tests which have been undertaken to verify the design

  15. Classification of symmetric toroidal orbifolds

    Energy Technology Data Exchange (ETDEWEB)

    Fischer, Maximilian; Ratz, Michael; Torrado, Jesus [Technische Univ. Muenchen, Garching (Germany). Physik-Department; Vaudrevange, Patrick K.S. [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany)

    2012-09-15

    We provide a complete classification of six-dimensional symmetric toroidal orbifolds which yield N{>=}1 supersymmetry in 4D for the heterotic string. Our strategy is based on a classification of crystallographic space groups in six dimensions. We find in total 520 inequivalent toroidal orbifolds, 162 of them with Abelian point groups such as Z{sub 3}, Z{sub 4}, Z{sub 6}-I etc. and 358 with non-Abelian point groups such as S{sub 3}, D{sub 4}, A{sub 4} etc. We also briefly explore the properties of some orbifolds with Abelian point groups and N=1, i.e. specify the Hodge numbers and comment on the possible mechanisms (local or non-local) of gauge symmetry breaking.

  16. Hollow nanotubular toroidal polymer microrings

    Science.gov (United States)

    Lee, Jiyeong; Baek, Kangkyun; Kim, Myungjin; Yun, Gyeongwon; Ko, Young Ho; Lee, Nam-Suk; Hwang, Ilha; Kim, Jeehong; Natarajan, Ramalingam; Park, Chan Gyung; Sung, Wokyung; Kim, Kimoon

    2014-02-01

    Despite the remarkable progress made in the self-assembly of nano- and microscale architectures with well-defined sizes and shapes, a self-organization-based synthesis of hollow toroids has, so far, proved to be elusive. Here, we report the synthesis of polymer microrings made from rectangular, flat and rigid-core monomers with anisotropically predisposed alkene groups, which are crosslinked with each other by dithiol linkers using thiol-ene photopolymerization. The resulting hollow toroidal structures are shape-persistent and mechanically robust in solution. In addition, their size can be tuned by controlling the initial monomer concentrations, an observation that is supported by a theoretical analysis. These hollow microrings can encapsulate guest molecules in the intratoroidal nanospace, and their peripheries can act as templates for circular arrays of metal nanoparticles.

  17. Transport and Dynamics in Toroidal Fusion Systems

    Energy Technology Data Exchange (ETDEWEB)

    Schnack, Dalton D

    2006-05-16

    This document reports the successful completion of the OFES Theory Milestone for FY2005, namely, Perform parametric studies to better understand the edge physics regimes of laboratory experiments. Simulate at increased resolution (up to 20 toroidal modes), with density evolution, late into the nonlinear phase and compare results from different types of edge modes. Simulate a single case including a study of heat deposition on nearby material walls. The linear stability properties and nonlinear evolution of Edge Localized Modes (ELMs) in tokamak plasmas are investigated through numerical computation. Data from the DIII-D device at General Atomics (http://fusion.gat.com/diii-d/) is used for the magnetohydrodynamic (MHD) equilibria, but edge parameters are varied to reveal important physical effects. The equilibrium with very low magnetic shear produces an unstable spectrum that is somewhat insensitive to dissipation coefficient values. Here, linear growth rates from the non-ideal NIMROD code (http://nimrodteam.org) agree reasonably well with ideal, i.e. non-dissipative, results from the GATO global linear stability code at low toroidal mode number (n) and with ideal results from the ELITE edge linear stability code at moderate to high toroidal mode number. Linear studies with a more realistic sequence of MHD equilibria (based on DIII-D discharge 86166) produce more significant discrepancies between the ideal and non-ideal calculations. The maximum growth rate for the ideal computations occurs at toroidal mode index n=10, whereas growth rates in the non-ideal computations continue to increase with n unless strong anisotropic thermal conduction is included. Recent modeling advances allow drift effects associated with the Hall electric field and gyroviscosity to be considered. A stabilizing effect can be observed in the preliminary results, but while the distortion in mode structure is readily apparent at n=40, the growth rate is only 13% less than the non-ideal MHD

  18. Activating Transcription Factor 3 (ATF3 and the Nervous System

    Directory of Open Access Journals (Sweden)

    Patrick Norval Anderson

    2012-02-01

    Full Text Available It has been recognised for over a century that the ability of axons to regenerate in peripheral nerves is fundamentally greater than that of axons in the brain, spinal cord or optic nerves [early literature was reviewed in (Ramon y Cajal, 1928]. One factor that contributes to the successful regeneration of the axons in peripheral nerves is the complex cell body response the neurons show to axotomy. That transcription factors must play an important role in enabling neurons to regrow their axons is implicit to the observation that several hundred genes are regulated in neurons during axonal regeneration (Costigan et al., 2002; Boeshore et al., 2004. In addition, similarly large numbers of genes are regulated in the non-neuronal cells present in injured peripheral nerves [especially Schwann cells (Barrette et al., 2010] and CNS tissue. Of the transcription factors that regulate these changes in gene expression, the function of c-jun is best understood but ATF-3 (also known as LRF-1, LRG-21, CRG-5 and TI-241 is also upregulated in most of the neurons (Fig. 1 and Schwann cells that express c-jun. Indeed, ATF-3 has become a standard marker for neurons axotomised by peripheral nerve injury (Tsuzuki et al., 2001; Yamanaka et al., 2005; Yano et al., 2008; Linda et al., 2011 and its expression by injured neurons is closely correlated with a regenerative response. None the less, surprisingly little is known about the functions of ATF3 in neurons or glia within the injured nervous system, especially when compared with those of its potential binding partner, c-Jun.

  19. Turn by Turn Measurements at the KEK-ATF

    CERN Document Server

    Renier, Y; Tomas, R; Wendt, M; Eddy, N; Kubo, K; Kuroda, S; Naito, T; Okugi, T; Terunuma, N; Urakawa, J

    2013-01-01

    The ATF damping ring has been upgraded with new read-out electronics for the beam position monitors (BPM), capable to acquire the beam orbits on a turn-by-turn basis, as well as in a high resolution averaging mode. The new BPM system allows to improve optic corrections and to achieve an even smaller vertical emittance (<2pm). Experimental results are presented based on turn-by-turn beam orbit measurements in the ring, for estimating the β functions and dispersion along the lattice. A fast method to measure spectral line amplitude in a few turns is also presented, including the evaluation of chromaticity.

  20. Antenna Test Facility (ATF): User Test Planning Guide

    Science.gov (United States)

    Lin, Greg

    2011-01-01

    Test process, milestones and inputs are unknowns to first-time users of the ATF. The User Test Planning Guide aids in establishing expectations for both NASA and non-NASA facility customers. The potential audience for this guide includes both internal and commercial spaceflight hardware/software developers. It is intended to assist their test engineering personnel in test planning and execution. Material covered includes a roadmap of the test process, roles and responsibilities of facility and user, major milestones, facility capabilities, and inputs required by the facility. Samples of deliverables, test article interfaces, and inputs necessary to define test scope, cost, and schedule are included as an appendix to the guide.

  1. Magnetic Properties of 3D Printed Toroids

    Science.gov (United States)

    Bollig, Lindsey; Otto, Austin; Hilpisch, Peter; Mowry, Greg; Nelson-Cheeseman, Brittany; Renewable Energy; Alternatives Lab (REAL) Team

    Transformers are ubiquitous in electronics today. Although toroidal geometries perform most efficiently, transformers are traditionally made with rectangular cross-sections due to the lower manufacturing costs. Additive manufacturing techniques (3D printing) can easily achieve toroidal geometries by building up a part through a series of 2D layers. To get strong magnetic properties in a 3D printed transformer, a composite filament is used containing Fe dispersed in a polymer matrix. How the resulting 3D printed toroid responds to a magnetic field depends on two structural factors of the printed 2D layers: fill factor (planar density) and fill pattern. In this work, we investigate how the fill factor and fill pattern affect the magnetic properties of 3D printed toroids. The magnetic properties of the printed toroids are measured by a custom circuit that produces a hysteresis loop for each toroid. Toroids with various fill factors and fill patterns are compared to determine how these two factors can affect the magnetic field the toroid can produce. These 3D printed toroids can be used for numerous applications in order to increase the efficiency of transformers by making it possible for manufacturers to make a toroidal geometry.

  2. 斑马鱼基因ATF4多克隆抗体的制备%Preparation of Polyclonal Antibody of ATF4 in Zebrafish

    Institute of Scientific and Technical Information of China (English)

    李发祥; 杨荣; 陈婷芳; 唐雄卓; 赵碧峰; 江志钢; 张义; 李永青; 吴秀山

    2012-01-01

    ATF4 , a member of the ATF/CREB transcription factor family which contains a bZIP domain, plays a important role in the embryonic development, cell proliferation and differentiation. Therefore, it is advisable to prepare an antibody for the heart development research in Zerbrafish. In this research, a ATF4-specific, hydrophilic nucleotide sequence (about 1 017 bp) was selected by using bioinformatics methods, and the sequence was amplified by PCR, the PCR product was inserted into the prokaryotic expression vector pET-28a and then transformed into Rosetta cells. After the sequence result of the recombinant plasmid pET-28a-ATF4 is verified to be right, the fusion protein was induced to express in Rosetta cells by IPTG. The mouse was immunized by injecting appropriate amount of fusion protein, and the ATF4 polyclonal antibody was obtained. The antibody' s titer and specification was identified. Our results showed that the ATF4 polyclonal antibody was practical and available for western-blotting analysis and immunohisto-chemistry.%ATF4是含有bZIP结构域的ATF/CREB转录因子家族成员,对胚胎的发育以及细胞的增殖、分化有重要的调节作用.制备ATF4的多克隆抗体对于研究其在斑马鱼心脏发育过程中的作用有重要的意义.研究首先通过生物信息学方法,选择ATF4基因中特异性强、具亲水性的一段核苷酸序列(1 017 bp),通过PCR扩增,将片段重组到原核表达载体pET-28a,然后转化人Rosetta菌株中.经测序鉴定正确后,用IPTG诱导表达融合蛋白,以该融合蛋白免疫小鼠,获得ATF4多克隆抗鼠血清.对该多抗血清抗体进行验证,具有很好特异性和较高效价,可以用作Western-blotting、免疫印迹等试验分析.

  3. Atf3 mutant mice show reduced axon regeneration and impaired regeneration-associated gene induction after peripheral nerve injury.

    Science.gov (United States)

    Gey, Manuel; Wanner, Renate; Schilling, Corinna; Pedro, Maria T; Sinske, Daniela; Knöll, Bernd

    2016-08-01

    Axon injury in the peripheral nervous system (PNS) induces a regeneration-associated gene (RAG) response. Atf3 (activating transcription factor 3) is such a RAG and ATF3's transcriptional activity might induce 'effector' RAGs (e.g. small proline rich protein 1a (Sprr1a), Galanin (Gal), growth-associated protein 43 (Gap43)) facilitating peripheral axon regeneration. We provide a first analysis of Atf3 mouse mutants in peripheral nerve regeneration. In Atf3 mutant mice, facial nerve regeneration and neurite outgrowth of adult ATF3-deficient primary dorsal root ganglia neurons was decreased. Using genome-wide transcriptomics, we identified a neuropeptide-encoding RAG cluster (vasoactive intestinal peptide (Vip), Ngf, Grp, Gal, Pacap) regulated by ATF3. Exogenous administration of neuropeptides enhanced neurite growth of Atf3 mutant mice suggesting that these molecules might be effector RAGs of ATF3's pro-regenerative function. In addition to the induction of growth-promoting molecules, we present data that ATF3 suppresses growth-inhibiting molecules such as chemokine (C-C motif) ligand 2. In summary, we show a pro-regenerative ATF3 function during PNS nerve regeneration involving transcriptional activation of a neuropeptide-encoding RAG cluster. ATF3 is a general injury-inducible factor, therefore ATF3-mediated mechanisms identified herein might apply to other cell and injury types. PMID:27581653

  4. Atf3 mutant mice show reduced axon regeneration and impaired regeneration-associated gene induction after peripheral nerve injury

    Science.gov (United States)

    Gey, Manuel; Wanner, Renate; Schilling, Corinna; Pedro, Maria T.; Sinske, Daniela

    2016-01-01

    Axon injury in the peripheral nervous system (PNS) induces a regeneration-associated gene (RAG) response. Atf3 (activating transcription factor 3) is such a RAG and ATF3's transcriptional activity might induce ‘effector’ RAGs (e.g. small proline rich protein 1a (Sprr1a), Galanin (Gal), growth-associated protein 43 (Gap43)) facilitating peripheral axon regeneration. We provide a first analysis of Atf3 mouse mutants in peripheral nerve regeneration. In Atf3 mutant mice, facial nerve regeneration and neurite outgrowth of adult ATF3-deficient primary dorsal root ganglia neurons was decreased. Using genome-wide transcriptomics, we identified a neuropeptide-encoding RAG cluster (vasoactive intestinal peptide (Vip), Ngf, Grp, Gal, Pacap) regulated by ATF3. Exogenous administration of neuropeptides enhanced neurite growth of Atf3 mutant mice suggesting that these molecules might be effector RAGs of ATF3's pro-regenerative function. In addition to the induction of growth-promoting molecules, we present data that ATF3 suppresses growth-inhibiting molecules such as chemokine (C-C motif) ligand 2. In summary, we show a pro-regenerative ATF3 function during PNS nerve regeneration involving transcriptional activation of a neuropeptide-encoding RAG cluster. ATF3 is a general injury-inducible factor, therefore ATF3-mediated mechanisms identified herein might apply to other cell and injury types. PMID:27581653

  5. Plasma Density Distribution Profile in Toroidal Discharge

    International Nuclear Information System (INIS)

    Tokamak is an electrode less toroidal plasma discharge system whichcontains and heats the plasma by using magnetic field and heating system suchas RF and neutral beams respectively. Using the system, tokamak is expectedto be a most advanced facility in fusion reactor concept. The importantparameters in tokamak are plasma current, plasma discharge voltage,temperature and density, plasma density profile and confinement time.However, the facility belonged to this center (P3TM) is very simple thatmeans a toroidal discharge without confinement magnetic filed and anadditional heating. The preceding result showed that it had been obtainedsome important parameters such as plasma current, discharge current, plasmavoltage and induced poloidal magnetic field. While plasma temperature andplasma density and its profile have not been observed. The one of somediagnostics to be used to determine this parameter is a Langmuir probe.Langmuir probe is an oldest diagnostic tool, simple and quite easy to bemade. The most advantage by using this probe is its ability to measure thecurrent locally. In this experiment, the home made Langmuir probe is atungsten wire with 0.8 mm in diameter enveloped by glass tube and inserted intorus tube. The torus is operated at 1 mbar argon gas pressure and 7.5 kVoperating voltage. The power source is a 330006 Maxwell type capacitor with15 micro farad, and charging system is a 825-100 Hipotronics model which canhold 20 kV of voltage and deliver 100 mA of current. The experiment resultshowed that the relative radial density profile has an exponential relationwith the approaching function is nrel ∝ e-0.54r, r isradial position. (author)

  6. Beam Transport in Toroidal Magnetic Field

    CERN Document Server

    Joshi, N; Meusel, O; Ratzinger, U

    2016-01-01

    The concept of a storage ring with toroidal magnetic field was presented in the two previous EPAC conferences. Here we report the first results of experiments performed with beam transport in toroidal magnetic fields and details of the injection system. The beam transport experiments were carried out with 30 degree toroidal segments with an axial magnetic field of 0.6T. The multi turn injection system relies on a transverse injection coil together with an electric kicker system.

  7. Trapped particle dynamics in toroidally rotating plasmas

    International Nuclear Information System (INIS)

    A detailed single particle orbit analysis is toroidally rotating plasma yields new analytical formulas for the second adiabatic invariant, the bounce frequency, and the precession frequency up to the first order correction in ρpi(poloidal ion gyroradium)/Lv(scale length of rotation velocity), for toroidal flow values of the order of ion thermal velocity. Toroidal plasma rotation effects on the trapped ion instabilities in tokamaks are investigated in the context of local theory. Toroidal plasma rotation increases both the fraction of trapped particles and their precession drift velocity. Consequently, the growth rate of trapped ion instability increases in both dissipative and collisionless regimes

  8. Computational modelling of compact toroidal plasmas

    International Nuclear Information System (INIS)

    Preliminary simulations of the formation of compact toroids are presented. This work is in support of current experiments in which compact toroids - a minimum magnetic energy configuration with linked toroidal and poloidal flux - are being formed, accelerated and compressed. Simulations were performed using MACH2, a 2D magnetohydrodynamic code with a newly implemented Van Lear transport scheme. Simulations also include a detailed modelling of the initial poloidal flux distribution produced by the external solenoidal coils, which is through to significantly effect the toroid's formation

  9. Pellet injection and toroidal confinement

    International Nuclear Information System (INIS)

    The proceedings of a technical committee meeting on pellet injection and toroidal confinement, held in Gut Ising, Federal Republic of Germany, 24-26 October, 1988, are given in this report. Most of the major fusion experiments are using pellet injectors; these were reported at this meeting. Studies of confinement, which is favorably affected, impurity transport, radiative energy losses, and affects on the ion temperature gradient instability were given. Studies of pellet ablation and effects on plasma profiles were presented. Finally, several papers described present and proposed injection guns. Refs, figs and tabs

  10. The transcription factor ATF3 acts as an oncogene in mouse mammary tumorigenesis

    Directory of Open Access Journals (Sweden)

    Thames Howard D

    2008-09-01

    Full Text Available Abstract Background Overexpression of the bZip transcription factor, ATF3, in basal epithelial cells of transgenic mice under the control of the bovine cytokeratin-5 (CK5 promoter has previously been shown to induce epidermal hyperplasia, hair follicle anomalies and neoplastic lesions of the oral mucosa including squamous cell carcinomas. CK5 is known to be expressed in myoepithelial cells of the mammary gland, suggesting the possibility that transgenic BK5.ATF3 mice may exhibit mammary gland phenotypes. Methods Mammary glands from nulliparous mice in our BK5.ATF3 colony, both non-transgenic and transgenic, were examined for anomalies by histopathology and immunohistochemistry. Nulliparous and biparous female mice were observed for possible mammary tumor development, and suspicious masses were analyzed by histopathology and immunohistochemistry. Human breast tumor samples, as well as normal breast tissue, were similarly analyzed for ATF3 expression. Results Transgenic BK5.ATF3 mice expressed nuclear ATF3 in the basal layer of the mammary ductal epithelium, and often developed squamous metaplastic lesions in one or more mammary glands by 25 weeks of age. No progression to malignancy was seen in nulliparous BK5.ATF3 or non-transgenic mice held for 16 months. However, biparous BK5.ATF3 mice developed mammary carcinomas with squamous metaplasia between 6 months and one year of age, reaching an incidence of 67%. Cytokeratin expression in the tumors was profoundly disturbed, including expression of CK5 and CK8 (characteristic of basal and luminal cells, respectively throughout the epithelial component of the tumors, CK6 (potentially a stem cell marker, CK10 (a marker of interfollicular epidermal differentiation, and mIRSa2 and mIRSa3.1 (markers of the inner root sheath of hair follicles. Immunohistochemical studies indicated that a subset of human breast tumors exhibit high levels of nuclear ATF3 expression. Conclusion Overexpression of ATF3 in CK5

  11. The transcription factor ATF3 acts as an oncogene in mouse mammary tumorigenesis

    International Nuclear Information System (INIS)

    Overexpression of the bZip transcription factor, ATF3, in basal epithelial cells of transgenic mice under the control of the bovine cytokeratin-5 (CK5) promoter has previously been shown to induce epidermal hyperplasia, hair follicle anomalies and neoplastic lesions of the oral mucosa including squamous cell carcinomas. CK5 is known to be expressed in myoepithelial cells of the mammary gland, suggesting the possibility that transgenic BK5.ATF3 mice may exhibit mammary gland phenotypes. Mammary glands from nulliparous mice in our BK5.ATF3 colony, both non-transgenic and transgenic, were examined for anomalies by histopathology and immunohistochemistry. Nulliparous and biparous female mice were observed for possible mammary tumor development, and suspicious masses were analyzed by histopathology and immunohistochemistry. Human breast tumor samples, as well as normal breast tissue, were similarly analyzed for ATF3 expression. Transgenic BK5.ATF3 mice expressed nuclear ATF3 in the basal layer of the mammary ductal epithelium, and often developed squamous metaplastic lesions in one or more mammary glands by 25 weeks of age. No progression to malignancy was seen in nulliparous BK5.ATF3 or non-transgenic mice held for 16 months. However, biparous BK5.ATF3 mice developed mammary carcinomas with squamous metaplasia between 6 months and one year of age, reaching an incidence of 67%. Cytokeratin expression in the tumors was profoundly disturbed, including expression of CK5 and CK8 (characteristic of basal and luminal cells, respectively) throughout the epithelial component of the tumors, CK6 (potentially a stem cell marker), CK10 (a marker of interfollicular epidermal differentiation), and mIRSa2 and mIRSa3.1 (markers of the inner root sheath of hair follicles). Immunohistochemical studies indicated that a subset of human breast tumors exhibit high levels of nuclear ATF3 expression. Overexpression of ATF3 in CK5-expressing cells of the murine mammary gland results in the

  12. Toroidal Field Ripple reduction studies for ITER and FAST

    International Nuclear Information System (INIS)

    Two different approaches to control the Toroidal Field Ripple (TFR) amplitude in ITER and FAST devices are presented in this paper. The approach currently adopted to reduce the TFR in ITER is based on the installation of ferromagnetic inserts between the vacuum vessel shells. The same approach has been analyzed in the design of the Fusion Advanced Studies Torus (FAST) proposal. Details of the system's layout are given. A new approach based on the insertion of active coils between the outer legs of the Toroidal Field Coils (TFCs) and the plasma, has been extensively investigated for these two machines. This active system would allow reducing the TFR to values even smaller than with the ferromagnetic inserts. The case of a localized disturb like that introduced by a Test Blanket Module (TBM) for ITER is presented where only well localized active coils can produce a significant ripple reduction.

  13. The toroidal field coil design for ARIES-ST

    International Nuclear Information System (INIS)

    An evolutionary process was used to develop the toroidal field (TF) coil design for the ARIES-ST (Spherical Tokamak). Design considerations included fabricability, assembly, maintenance, energy efficiency, and structural robustness. The design addresses a number of the concerns (complexity) and criticisms (high cost, high recirculating power) of fusion. It does this by: (1) Applying advanced, but available laser forming and spray casting techniques for manufacturing the TF coil system; (2) Adopting a simple single toroidal field coil system to make assembly and maintenance much easier, the single turn design avoids the necessity of using the insulation as a structural component of the TF coils, and hence is much more robust than multi-turn designs; and (3) Using a high conductivity copper alloy and modest current densities to keep the recirculating power modest

  14. Toroidal Theory of MHD Instabilities

    International Nuclear Information System (INIS)

    We continue with the adventures of the Alfven wave and its two magnetosonic companions as they travel in the curved space of magnetic surfaces and field lines (Sec. 2), find themselves trapped in singularities of an unprecedented richness (Sec. 3), decide to get themselves better maps of the landscape to do the required twisting while some of their youthful energy is leaking away (Sec. 4), cause trouble at the edge of a powerful empire (Sec. 5), and finally see the light in a distant future (Sec. 6). Needed on the trip are the evolution equations of both ideal and resistive MHD 'derived' in reference [1], the solutions to the toroidal equilibrium equations discussed in reference [2], the general background on spectral theory of inhomogeneous plasmas presented in reference [3], which is extended in the two directions of toroidal geometry and resistivity in this lecture [4]. This leads to such intricate dynamics that numerical techniques are virtually the only way to proceed. This aspect is further elaborated in reference [5] on numerical techniques

  15. Functional interaction of TCF4 with ATF5 to regulate the Wnt signaling pathway

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    Wnt signaling directs cell-fate choices during embryonic development and tissue tumorigenesis. T cell factor 4 (TCF4) plays a pivotal role in the Wnt signaling pathway. We demonstrate that a specific protein-protein interaction occurs between TCF4 and ATF5 (activating transcription factor 5) -- a new member of cAMP response element binding protein (CREB) with the yeast two-hybrid system. The N-terminal and DNA binding domain of TCF4 (TCF4ND, 1-495 aa) and the C-terminal spanning bZIP domain of ATF5 (162-282 aa) were found to be responsible for the interaction, and the C-terminal of ATF5 (ATF5/C) showed a much stronger interaction with TCF4ND than the full-length of ATF5 by detecting the ?-gal activity. Furthermore, overexpression of ATF5/C enhanced transcriptional activation by TCF4 proteins in luciferase assay by transient transfection. Taken together, these data suggest that ATF5 may function as a co-activator to potentiate the ability of TCF4 to activate transcription.

  16. Loss of ATF2 function leads to cranial motoneuron degeneration during embryonic mouse development.

    Directory of Open Access Journals (Sweden)

    Julien Ackermann

    Full Text Available The AP-1 family transcription factor ATF2 is essential for development and tissue maintenance in mammals. In particular, ATF2 is highly expressed and activated in the brain and previous studies using mouse knockouts have confirmed its requirement in the cerebellum as well as in vestibular sense organs. Here we present the analysis of the requirement for ATF2 in CNS development in mouse embryos, specifically in the brainstem. We discovered that neuron-specific inactivation of ATF2 leads to significant loss of motoneurons of the hypoglossal, abducens and facial nuclei. While the generation of ATF2 mutant motoneurons appears normal during early development, they undergo caspase-dependent and independent cell death during later embryonic and foetal stages. The loss of these motoneurons correlates with increased levels of stress activated MAP kinases, JNK and p38, as well as aberrant accumulation of phosphorylated neurofilament proteins, NF-H and NF-M, known substrates for these kinases. This, together with other neuropathological phenotypes, including aberrant vacuolisation and lipid accumulation, indicates that deficiency in ATF2 leads to neurodegeneration of subsets of somatic and visceral motoneurons of the brainstem. It also confirms that ATF2 has a critical role in limiting the activities of stress kinases JNK and p38 which are potent inducers of cell death in the CNS.

  17. Construction and Activity Assay of the Activating Transcription Factor 3 Reporter Vector pATF/CRE-luc

    Institute of Scientific and Technical Information of China (English)

    Jun-Qing XU; Jing-Lan DENG; You-Sheng WU; Han-Yan FU; Rui-Hua WANG; Jian ZHANG; Fan LU; Zhong-Liang ZHAO

    2006-01-01

    Activating transcription factor 3 (ATF3), a member of the activating transcription factor/cAMP responsive element binding protein (ATF/CREB) family of transcription factors, is induced by many physiological stresses. To investigate the activity of ATF/CREB in cells with physiological stresses, we developed a practical reporter vector, the plasmid pATF/CRE-luc, bearing activating transcription factor/cAMP responsive element (ATF/CRE) binding sites. This plasmid was constructed by inserting three repeats of the ATF/CRE binding element into the plasmid pG51uc, replacing the GAL-4 binding sites. The plasmids pACT/ATF3 and pATF/CRE-luc were transfected into HeLa and NIH3T3 cells, respectively, and the results showed that the expression of luciferase was increased in a dose-dependent manner on plasmid pACT/ATF3. The data suggested that the plasmid pATF/CRE-luc could be used as a sensitive and convenient reporter system of ATF3 activity.

  18. Toroidal Alfven wave stability in ignited tokamaks

    Energy Technology Data Exchange (ETDEWEB)

    Cheng, C.Z.; Fu, G.Y.; Van Dam, J.W.

    1989-01-01

    The effects of fusion-product alpha particles on the stability of global-type shear Alfven waves in an ignited tokamak plasma are investigated in toroidal geometry. Finite toroidicity can lead to stabilization of the global Alfven eigenmodes, but it induces a new global shear Alfven eigenmodes, which is strongly destabilized via transit resonance with alpha particles. 8 refs., 2 figs.

  19. Electrostatics of a Family of Conducting Toroids

    Science.gov (United States)

    Lekner, John

    2009-01-01

    An exact solution is found for the electrostatic potential of a family of conducting charged toroids. The toroids are characterized by two lengths "a" and "b", with "a" greater than or equal to "2b". They are closed, with no hole in the "doughnut". The results are obtained by considering the potential of two equal charges, displaced from the…

  20. Localisation of beam offset jitter sources at ATF2

    CERN Document Server

    Pfingstner, J; Patecki, M; Schulte, D; Tomás, R

    2014-01-01

    For the commissioning and operation of modern particle accelerators, automated error detection and diagnostics methods are becoming increasingly important. In this paper, we present two such methods, which are capable of localising sources of beam offset jitter with a combination of correlation studies and so called degree of freedom plots. The methods were applied to the ATF2 beam line at KEK, where one of the major goals is the reduction of the beam offset jitter. Results of this localisation are shown in this paper. A big advantage of the presented method is its high robustness especially to varying optics parameters. Therefore, we believe that the developed beam offset jitter localisation methods can be easily applied to other accelerators.

  1. Effects of magnetic field perturbations in the ATF torsatron

    International Nuclear Information System (INIS)

    The effects of errors in the magnetic fields of tokamaks on the plasma are quite different from those in stellarators. In tokamaks, field errors can cause disruptive locked modes through the non-linear evolution of tearing modes acting on initially small error-induced islands. Scaling predictions for these effects indicate that the critical relative field error which can be tolerated becomes smaller as the tokamak size becomes larger. In stellarators, the effect is more benign, as field errors appear only to cause increased plasma transport in the vicinity of islands. Great care has been taken to minimize magnetic field errors in the most recent generation of stellarator-type magnetic plasma traps. In the past six years, several new and sensitive techniques have been developed to detect and map field errors. These methods all rely on the detection of electrons injected along magnetic field lines. During the commissioning of ATF, flux surfaces were mapped using the fluorescent screen technique. Field errors were discovered and traced to uncompensated dipoles in the helical current feeds. Prior to elimination of these errors, plasma discharges indicated centrally peaked plasma profiles. After correction of the uncompensated dipoles, flux surfaces were mapped a second time, and the island widths were found to be greatly reduced. Field errors were then deliberately introduced using a set of perturbation coils that had been added to ATF, and electron-beam mapping of the flux surfaces showed that islands several centimeters in width could easily be created by these coils. After elimination of the error fields, the measured plasma temperature and density profiles were much broader. The field-perturbation coils were then used to produce magnetic field asymmetries, and the measured plasma profiles were again shown to narrow as a result of islands

  2. Cutoff frequency of toroidal plasma waveguide

    International Nuclear Information System (INIS)

    The cutoff frequencies of E and H-modes of empty and plasma filled toroidal waveguides are evaluated. The effects of space curvature and plasma density on cutoff frequencies for both modes are investigated. Using a suitable variable change, a scalar wave equation in the direction of propagation was obtained. The study indicates that the curvature in the direction of wave propagation in toroidal waveguide has an analogous effect as a straight waveguide filled with anisotropic media. The Rayleigh-Schrodinger perturbation method was employed to solve for cutoff frequencies in the first order of approximation. In the limit of small space curvature, the toroidal waveguide cutoff frequencies for both E and H-modes approach those of TM and TE modes of empty cylindrical waveguide with a radius equal to toroidal waveguide minor radius. The analysis shows that the curvature in the direction of propagation in toroidal waveguides leads to the removal of the degeneracy between E and H-modes

  3. Asymmetric Magnon Excitation by Spontaneous Toroidal Ordering

    Science.gov (United States)

    Hayami, Satoru; Kusunose, Hiroaki; Motome, Yukitoshi

    2016-05-01

    The effects of spontaneous toroidal ordering on magnetic excitation are theoretically investigated for a localized spin model that includes a staggered Dzyaloshinsky-Moriya interaction and anisotropic exchange interactions, which arise from the antisymmetric spin-orbit coupling and the multiorbital correlation effect. We show that the model exhibits a Néel-type antiferromagnetic order, which simultaneously accompanies a ferroic toroidal order. We find that the occurrence of toroidal order modulates the magnon dispersion in an asymmetric way with respect to the wave number: a toroidal dipole order on the zigzag chain leads to a band-bottom shift, while a toroidal octupole order on the honeycomb lattice gives rise to a valley splitting. These asymmetric magnon excitations could be a source of unusual magnetic responses, such as nonreciprocal magnon transport. A variety of modulations are discussed while changing the lattice and magnetic symmetries. The implications regarding candidate materials for asymmetric magnon excitations are presented.

  4. Toroidal Vortices in Resistive Magnetohydrodynamic Equilibria

    CERN Document Server

    Montgomery, D C; Li, S; Montgomery, David; Bates, Jason W.; Li, Shuojun

    1996-01-01

    Resistive steady states in toroidal magnetohydrodynamics (MHD), where Ohm's law must be taken into account, differ considerably from ideal ones. Only for special (and probably unphysical) resistivity profiles can the Lorentz force, in the static force-balance equation, be expressed as the gradient of a scalar and thus cancel the gradient of a scalar pressure. In general, the Lorentz force has a curl directed so as to generate toroidal vorticity. Here, we calculate, for a collisional, highly viscous magnetofluid, the flows that are required for an axisymmetric toroidal steady state, assuming uniform scalar resistivity and viscosity. The flows originate from paired toroidal vortices (in what might be called a ``double smoke ring'' configuration), and are thought likely to be ubiquitous in the interior of toroidally driven magnetofluids of this type. The existence of such vortices is conjectured to characterize magnetofluids beyond the high-viscosity limit in which they are readily calculable.

  5. Development of Toroidal Core Transformers

    Energy Technology Data Exchange (ETDEWEB)

    Leon, Francisco

    2014-05-31

    The original objective of this project was to design, build and test a few prototypes of singlephase dry-type distribution transformers of 25 kVA, 2.4 kV primary to 120 V transformers using cores made of a continuous steel strip shaped like a doughnut (toroid). At different points during the development of the project, the scope was enhanced to include the more practical case of a 25 kVA transformer for a 13.8 kV primary system voltage. Later, the scope was further expanded to design and build a 50 kVA unit to transformer voltage from 7.62 kV to 2x120 V. This is a common transformer used by Con Edison of New York and they are willing to test it in the field. The project officially started in September 2009 and ended in May 2014. The progress was reported periodically to DOE in eighteen quarterly reports. A Continuation Application was submitted to DOE in June 2010. In May 2011 we have requested a non-cost extension of the project. In December 2011, the Statement of Project Objectives (SOPO) was updated to reflect the real conditions and situation of the project as of 2011. A second Continuation Application was made and funding was approved in 2013 by DOE and the end date was extended to May 2014.The technical challenges that were overcome in this project include: the development of the technology to pass the impulse tests, derive a model for the thermal performance, produce a sound mechanical design, and estimate the inrush current. However, the greatest challenge that we faced during the development of the project was the complications of procuring the necessary parts and materials to build the transformers. The actual manufacturing process is relatively fast, but getting all parts together is a very lengthy process. The main products of this project are two prototypes of toroidal distribution transformers of 7.62 kV (to be used in a 13.8 kV system) to 2x120 V secondary (standard utilization voltage); one is rated at 25 kVA and the other at 50 kVA. The 25 k

  6. ATF6α/β-mediated adjustment of ER chaperone levels is essential for development of the notochord in medaka fish.

    OpenAIRE

    Ishikawa, Tokiro; Okada, Tetsuya; Ishikawa-Fujiwara, Tomoko; Todo, Takeshi; Kamei, Yasuhiro; Shigenobu, Shuji; Tanaka, Minoru; Saito, Taro L; Yoshimura, Jun; Morishita, Shinichi; Toyoda, Atsushi; Sakaki, Yoshiyuki; Taniguchi, Yoshihito; Takeda, Shunichi; Mori, Kazutoshi

    2013-01-01

    ATF6α and ATF6β are membrane-bound transcription factors activated by regulated intramembrane proteolysis in response to endoplasmic reticulum (ER) stress to induce various ER quality control proteins. ATF6α- and ATF6β single-knockout mice develop normally, but ATF6α/β double knockout causes embryonic lethality, the reason for which is unknown. Here we show in medaka fish that ATF6α is primarily responsible for transcriptional induction of the major ER chaperone BiP and that ATF6α/β double kn...

  7. ATF6α/β-mediated adjustment of ER chaperone levels is essential for development of the notochord in medaka fish

    OpenAIRE

    Ishikawa, Tokiro; Okada, Tetsuya; Ishikawa-Fujiwara, Tomoko; Todo, Takeshi; Kamei, Yasuhiro; Shigenobu, Shuji; Tanaka, Minoru; Saito, Taro L; Yoshimura, Jun; Morishita, Shinichi; Toyoda, Atsushi; Sakaki, Yoshiyuki; Taniguchi, Yoshihito; Takeda, Shunichi; Mori, Kazutoshi

    2013-01-01

    ATF6α and ATF6β are membrane-bound transcription factors activated by regulated intramembrane proteolysis in response to endoplasmic reticulum (ER) stress to induce various ER quality control proteins. ATF6α- and ATF6β single-knockout mice develop normally, but ATF6α/β double knockout causes embryonic lethality, the reason for which is unknown. Here we show in medaka fish that ATF6α is primarily responsible for transcriptional induction of the major ER chaperone BiP and that ATF6α/β double kn...

  8. Tokamak with mechanical compression of toroidal magnetic field

    Science.gov (United States)

    Ohkawa, Tihiro

    1981-01-01

    A tokamak apparatus includes a pressure vessel for defining a reservoir and confining liquid therein. A collapsible toroidal liner disposed within the pressure vessel defines a toroidal space within the liner. Liquid metal fills the reservoir outside said liner. A toroidal magnetic field is developed within the toroidal space about the major axis thereof. A toroidal plasma is developed within the toroidal space about the major axis thereof. Pressure is applied to the liquid metal to collapse the liner and reduce the volume of the toroidal space, thereby increasing the toroidal magnetic flux density therein.

  9. Compact toroid fueling for ITER

    International Nuclear Information System (INIS)

    Experimental and theoretical work indicates that deep fueling of ITER may be possible by Compact Toroid (CT) injection. CT velocities sufficient for center fueling of a reactor have been demonstrated in the RACE device. CT injections into the TdeV tokamak have achieved central penetration at 1.4 T, and have increased the particle inventory by more than 30% without disruption. Tests on the MARAUDER device have achieved CT mass-densities suitable for injection into 5 T tokamaks. Techniques for producing multiple-shot CT's with passive electric switching are being tested on CTIX. The advantages of deep fueling by CT injection include profile peaking to reach ignition, profile control, low tritium inventory and others. In this paper, the CT experimental results are summarized, a conceptual design of a CT fueler for ITER is presented, and the implications on ITER operation and fuel cycle are discussed. 16 refs., 2 figs., 1 tab

  10. NCSX Toroidal Field Coil Design

    Energy Technology Data Exchange (ETDEWEB)

    Kalish, M.; Rushinski, J.; Myatt, L.; Brooks, A.; Dahlgren, F.; Chrzanowski, J.; Reiersen, W.; Freudenberg, K.

    2005-10-07

    The National Compact Stellarator Experiment (NCSX) is an experimental device whose design and construction is underway at the Department of Energy's Princeton Plasma Physics Laboratory (PPPL). The primary coil systems for the NCSX device consist of the twisted plasma-shaping Modular Coils, the Poloidal Field Coils, and the Toroidal Field (TF) Coils. The TF Coils are D-shaped coils wound from hollow copper conductor, and vacuum impregnated with a glass-epoxy resin system. There are 18 identical, equally spaced TF coils providing 1/R field at the plasma. They operate within a cryostat, and are cooled by LN2, nominally, to 80K. Wedge shaped castings are assembled to the inboard face of these coils, so that inward radial loads are reacted via the nesting of each of the coils against their adjacent partners. This paper outlines the TF Coil design methodology, reviews the analysis results, and summarizes how the design and analysis support the design requirements.

  11. Compact toroid injection into C-2U

    Science.gov (United States)

    Roche, Thomas; Gota, H.; Garate, E.; Asai, T.; Matsumoto, T.; Sekiguchi, J.; Putvinski, S.; Allfrey, I.; Beall, M.; Cordero, M.; Granstedt, E.; Kinley, J.; Morehouse, M.; Sheftman, D.; Valentine, T.; Waggoner, W.; the TAE Team

    2015-11-01

    Sustainment of an advanced neutral beam-driven FRC for a period in excess of 5 ms is the primary goal of the C-2U machine at Tri Alpha Energy. In addition, a criteria for long-term global sustainment of any magnetically confined fusion reactor is particle refueling. To this end, a magnetized coaxial plasma-gun has been developed. Compact toroids (CT) are to be injected perpendicular to the axial magnetic field of C-2U. To simulate this environment, an experimental test-stand has been constructed. A transverse magnetic field of B ~ 1 kG is established (comparable to the C-2U axial field) and CTs are fired across it. As a minimal requirement, the CT must have energy density greater than that of the magnetic field it is to penetrate, i.e., 1/2 ρv2 >=B2 / 2μ0 . This criteria is easily met and indeed the CTs traverse the test-stand field. A preliminary experiment on C-2U shows the CT also capable of penetrating into FRC plasmas and refueling is observed resulting in a 20 - 30% increase in total particle number per single-pulsed CT injection. Results from test-stand and C-2U experiments will be presented.

  12. Divest yourself of a preconceived idea: transcription factor ATF6 is not a soluble protein!

    Science.gov (United States)

    Mori, Kazutoshi

    2010-05-01

    The unfolded protein response (UPR), an evolutionarily conserved transcriptional induction program that is coupled with intracellular signaling from the endoplasmic reticulum (ER) to the nucleus, is activated to cope with ER stress and to maintain the homeostasis of the ER. In 1996, we isolated a basic leucine zipper protein, which had been previously named activating transcription factor (ATF)6, as a candidate transcription factor responsible for the mammalian UPR. Subsequent analysis, however, was confounding. The problem was eventually tracked down to an unusual property of ATF6: rather than being a soluble nuclear protein, as expected for an active transcription factor, ATF6 was instead synthesized as a transmembrane protein embedded in the ER, which was activated by ER stress-induced proteolysis. ATF6 was thus unique: an ER stress sensor/transducer that is involved in all steps of the UPR, from the sensing step in the ER to the transcriptional activation step in the nucleus. PMID:20219975

  13. Piperonyl butoxide activates c-Jun and ATF-2 in the hepatocytes of mice

    Energy Technology Data Exchange (ETDEWEB)

    Muguruma, Masako; Moto, Mitsuyoshi; Mitsumori, Kunitoshi [Tokyo University of Agriculture and Technology, Laboratory of Veterinary Pathology, Faculty of Agriculture, Tokyo (Japan); Arai, Katsuhiko [Tokyo University of Agriculture and Technology, Department of Tissue Physiology, Faculty of Agriculture, Tokyo (Japan); Nishimura, Jihei; Dewa, Yasuaki [Tokyo University of Agriculture and Technology, Laboratory of Veterinary Pathology, Faculty of Agriculture, Tokyo (Japan); Gifu University, United Graduate School of Veterinary Sciences, Gifu (Japan)

    2008-10-15

    In order to clarify the possible mechanism of hepatocarcinogenesis induced by piperonyl butoxide, we attempted to identify the transcription factor activated by piperonyl butoxide in the male ICR mouse liver. Administration of 0.6% piperonyl butoxide for 24 h elevated the level of liver nuclear proteins that bind to an AP-1 consensus oligonucleotide, and these proteins demonstrated a supershift with the anti-c-Jun antibody. Additionally, immunoblot analysis revealed that piperonyl butoxide induced c-Jun phosphorylation within 8 h of administration, and phosphorylated ATF-2 was detected after 24 h of piperonyl butoxide treatment. Immunohistochemical analysis also demonstrated the presence of phosphorylated ATF-2 in the hepatocyte nuclei of mice fed with 0.6% piperonyl butoxide for 24 h. Furthermore, piperonyl butoxide induced ATF-2 phosphorylation in TLR-3, a mouse immortalized hepatocyte cell line. These results indicated that piperonyl butoxide activated c-Jun and ATF-2 in mouse hepatocytes during the early stage of hepatocarcinogenesis. (orig.)

  14. The toroid moment of Majorana neutrino

    International Nuclear Information System (INIS)

    The total set of electromagnetic characteristics of Majorana neutrinos is considered. It is shown that in the static limit (mi=mf=mν) the Majorana neutrinos possess only one electromagnetic characteristic, the toroidal dipole moment (anapole). We have calculated the diagonal toroidal moment (form factor) of the Majorana neutrino in the one-loop approximation of the Standard Model by the dispersion method. All external particles are on the mass shells and there are no problems with the physical interpretation of the final result. Different applications of the toroidal moment of Majorana neutrino are also discussed. 12 refs., 2 figs., 1 tab

  15. ATF-2 immunoreactivity in post-mitotic and terminally differentiated human odontoblasts.

    Science.gov (United States)

    Keklikoglu, Nurullah; Akinci, Sevtap

    2015-09-01

    Activating transcription factor 2 (ATF-2/CRE-BP1; cAMP-responsive element binding protein 1) is a member of nuclear transcription factor activator protein-1 (AP-1) family. AP-1 regulates cellular processes including growth, proliferation, differentiation and apoptosis. However, biological relationship of cellular process to each member of the AP-1 family is not clear yet. The objective of the present study was to compare the ATF-2 immunoreactivity in the post-mitotic and terminally differentiated odontoblasts and in the pulpal fibroblasts which can be divided by mitosis when required. Fibroblasts at various stages of differentiation co-exist in the human dental pulp. ATF-2 was investigated immunohistochemically in 20 permanent human teeth. According to the findings obtained, the mean percentage of ATF-2 positive cells was 68.5 ± 19.2% in the odontoblasts and 22.8 ± 13.7% in the pulpal fibroblasts. The comparison of ATF-2 positivity revealed a statistically significant difference between odontoblasts and pulpal fibroblasts. These findings have suggested that ATF-2 is more associated with cell survival rather than cell proliferation, and revealed much of effectiveness in maintaining terminal differentiation than the various differentiation stages of the cells. PMID:25417007

  16. Development of Electronics for the ATF2 Interaction Point Region Beam Position Monitor

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Youngim; /Kyungpook Natl. U.; Heo, Ae-young; /Kyungpook Natl. U.; Kim, Eun-San; /Kyungpook Natl. U.; Boogert, Stewart; /Royal Holloway, U. of London; Honda, Yosuke; /KEK, Tsukuba; Tauchi, Toshiaki; /KEK, Tsukuba; Terunuma, Nobuhiro; /KEK, Tsukuba; May, Justin; /SLAC; McCormick, Douglas; /SLAC; Smith, Tonee; /SLAC

    2012-08-14

    Nanometer resolution beam position monitors have been developed to measure and control beam position stability at the interaction point region of ATF2. The position of the beam has to be measured to within a few nanometers at the interaction point. In order to achieve this performance, electronics for the low-Q IP-BPM was developed. Every component of the electronics have been simulated and checked on the bench and using the ATF2 beam. We will explain each component and define their working range. Then, we will show the performance of the electronics measured with beam signal. ATF2 is a final focus test beam line for ILC in the framework of the ATF international collaboration. The new beam line was constructed to extend the extraction line at ATF, KEK, Japan. The first goal of ATF2 is the acheiving of a 37 nm vertical beam size at focal point (IP). The second goal is to stabilize the beam at the focal point at a few nanometer level for a long period in order to ensure the high luminosity. To achieve these goals a high resolution IP-BPM is essential. In addition for feedback applications a low-Q system is desirable.

  17. Tokamak with in situ magnetohydrodynamic generation of toroidal magnetic field

    Science.gov (United States)

    Schaffer, Michael J.

    1986-01-01

    A tokamak apparatus includes an electrically conductive metal pressure vessel for defining a chamber and confining liquid therein. A liner disposed within said chamber defines a toroidal space within the liner and confines gas therein. The metal vessel provides an electrically conductive path linking the toroidal space. Liquid metal is forced outwardly through the chamber outside of the toroidal space to generate electric current in the conductive path and thereby generate a toroidal magnetic field within the toroidal space. Toroidal plasma is developed within the toroidal space about the major axis thereof.

  18. Toroidal Horizons in Binary Black Hole Mergers

    CERN Document Server

    Bohn, Andy; Teukolsky, Saul A

    2016-01-01

    We find the first binary black hole event horizon with a toroidal topology. It had been predicted that generically the event horizons of merging black holes should briefly have a toroidal topology, but such a phase has never been seen prior to this work. In all previous binary black hole simulations, in the coordinate slicing used to evolve the black holes, the topology of the event horizon transitions directly from two spheres during the inspiral to a single sphere as the black holes merge. We present a coordinate transformation to a foliation of spacelike hypersurfaces that "cut a hole" through the event horizon surface, resulting in a toroidal event horizon. A torus could potentially provide a mechanism for violating topological censorship. However, these toroidal event horizons satisfy topological censorship by construction, because we can always trivially apply the inverse coordinate transformation to remove the topological feature.

  19. OCLATOR (One Coil Low Aspect Toroidal Reactor)

    International Nuclear Information System (INIS)

    A new approach to construct a tokamak-type reactor(s) is presented. Basically the return conductors of toroidal field coils are eliminated and the toroidal field coil is replaced by one single large coil, around which there will be placed several tokamaks or other toroidal devices. The elimination of return conductors should, in addition to other advantages, improve the accessibility and maintainability of the tokamaks and offer a possible alternative to the search for special materials to withstand large neutron wall loading, as the frequency of changeover would be increased due to minimum downtime. It also makes it possible to have a low aspect ratio tokamak which should improve the β limit, so that a low toroidal magnetic field strength might be acceptable, meaning that the NbTi superconducting wire could be used. This system is named OCLATOR

  20. LASL toroidal reversed-field pinch programme

    International Nuclear Information System (INIS)

    The determination of the absolute energy loss due to radiation from impurities in the LASL toroidal reversed-field pinch experiment ZT-S is reported. The measurements show that over half the energy loss is accounted for by this mechanism. Thomson-scattering electron density measurements indicate only a gradual increase in temperature as the filling pressure is reduced, indicating an increased energy loss at lower pressures. Cylindrical and toroidal simulations of the experiment indicate either that a highly radiative pinch boundary or anomalous transport is needed to match the experimental results. New effects on the equilibrium due to plasma flows induced by the toroidal geometry are predicted by the toroidal simulations. The preliminary results on the low-temperature discharge cleaning of the ZT-S torus are reported. A description of the upgrade of the ZT-S experiment and the objectives, construction and theoretical predictions for the new ZT-40 experiment are given. (author)

  1. PIV-Analysis of collapsing toroidal droplets

    Science.gov (United States)

    Pairam, Ekapop; Berger, Eric; Fernandez-Nieves, Alberto; Georgia Tech Team

    2012-11-01

    Toroidal droplets are unstable and always undergo a transformation into spherical droplets driven by surface tension. They either break ala Rayleigh-Plateau if the torus is thin or grow fatter to become a single spherical droplet if the torus is fat. We analyze the velocity field inside and outside the toroidal droplet as it transforms into spherical droplets using the particle image velocimetry (PIV) method and compare with recent theoretical calculations for this process. NSF CAREER.

  2. Celebrating the Barrel Toroid commissioning

    CERN Multimedia

    Peter Jenni

    ATLAS invited Funding Agency representatives and Laboratory Heads directly related to the funding and construction of the Barrel Toroid for a small ceremony on 13th December 2006 at Point 1, in order to mark the successful first full excitation of the BT (see last eNews). On that date, which was during the December CERN Council week, several of the Funding Agency Heads or their representatives could be present, representing CEA France, INFN Italy, BMBF Germany, Spain, Sweden, Switzerland, Russia, JINR Dubna and CERN. Speeches were delivered by the ATLAS spokesperson Peter Jenni thanking the Funding Partners in the name of the Collaboration, by Magnet Project Leader Herman ten Kate tracing the BT construction history, and by the CERN Director-General Robert Aymar congratulating all those who have contributed to the successful project. Herman ten Kate addressing the delegates. The text of the introductory address by Peter Jenni is reproduced here. "It is a great pleasure for me to welcome you all here...

  3. Anomalous transport in toroidal plasmas

    International Nuclear Information System (INIS)

    When the magnetic moment of particle is conserved, there are three mechanisms which cause anomalous transport. These are: variation of magnetic field strength in flux surface, variation of electrostatic potential in flux surface, and destruction of flux surface. The anomalous transport of different groups of particles resulting from each of these mechanisms is different. This fact can be exploited to determine the cause of transport operative in an experimental situation. This approach can give far more information on the transport than the standard confinement time measurements. To implement this approach, we have developed Monte Carlo codes for toroidal geometries. The equations of motion are developed in a set of non-canonical, practical Boozer co-ordinates by means of Jacobian transformations of the particle drift Hamiltonian equations of motion. Effects of collisions are included by appropriate stochastic changes in the constants of motion. Effects of the loop voltage on particle motions are also included. We plan to apply our method to study two problems: the problem of the hot electron tail observed in edge region of ZT-40, and the energy confinement time in TOKAPOLE II. For the ZT-40 problem three situations will be considered: a single mode in the core, a stochastic region that covers half the minor radius, a stochastic region that covers the entire plasma. A turbulent spectrum of perturbations based on the experimental data of TOKAPOLE II will be developed. This will be used to simulate electron transport resulting from ideal instabilities and resistive instabilities in TOKAPOLE II

  4. Proceedings of the 2nd ATF international collaboration meeting

    International Nuclear Information System (INIS)

    Following the first one at SLAC in November 1996, the second ATF international collaboration meeting was held at KEK from June 12 and 13, 1997. In total 65 persons attended and 23 among them were from abroad as the first one held at SLAC November, 1996. While the main topic at the first meeting had been on the injection linac commissioning started in November 1995, this time its was on the damping ring which almost on schedule was put into operation in January 1997, after its 5 year long construction. Worldwide contributions, especially that of SLAC, were of vital importance in the design and construction of the ring. In the ring commissioning, however, ever more people from abroad have much enthusiastically taken part in various studies to achieve lower emittances. Thus it was the first task in the meeting to summarize the activities in these 6 months. Since a full system to measure the low emittances is to be completed in the shutdown of this summer, the other important task of the meeting for all attendants was to think very carefully about the work in the shutdown and study programs after it. (J.P.N.)

  5. Low-n shear Alfven spectra in axisymmetric toroidal plasmas

    International Nuclear Information System (INIS)

    In toroidal plasmas, the toroidal magnetic field is nonuniform over a magnetic surface and causes coupling of different poloidal harmonics. It is shown both analytically and numerically that the toroidicity not only breaks up the shear Alfven continuous spectrum, but also creates new, discrete, toroidicity-induced shear Alfven eigenmodes with frequencies inside the continuum gaps. Potential applications of the low-n toroidicity-induced shear Alfven eigenmodes on plasma heating and instabilities are addressed. 17 refs., 4 figs

  6. Role of Disulfide Bridges Formed in the Luminal Domain of ATF6 in Sensing Endoplasmic Reticulum Stress▿

    OpenAIRE

    Nadanaka, Satomi; Okada, Tetsuya; Yoshida, Hiderou; MORI, Kazutoshi

    2006-01-01

    ATF6 is a membrane-bound transcription factor activated by proteolysis in response to endoplasmic reticulum (ER) stress to induce the transcription of ER chaperone genes. We show here that, owing to the presence of intra- and intermolecular disulfide bridges formed between the two conserved cysteine residues in the luminal domain, ATF6 occurs in unstressed ER in monomer, dimer, and oligomer forms. Disulfide-bonded ATF6 is reduced upon treatment of cells with not only the reducing reagent dith...

  7. Berberine, a natural isoquinoline alkaloid, induces NAG-1 and ATF3 expression in human colorectal cancer cells

    OpenAIRE

    Piyanuch, Rojsanga; Sukhthankar, Mugdha; Baek, Seung Joon

    2007-01-01

    Berberine is known to possess a wide variety of pharmacological activities, including pro-apoptotic activity. However, its molecular targets are not elucidated at present. NAG-1 and ATF3 are induced by several dietary compounds associated with pro-apoptotic activity. Berberine induces cell growth arrest, apoptosis, NAG-1, and ATF3 in human colorectal cancer cells. ATF3 induction by berberine is mediated in a p53-dependent manner, whereas NAG-1 induction by berberine is mediated by multiple si...

  8. Resistive instabilities in toroidal confinement

    International Nuclear Information System (INIS)

    Low-m tearing modes constitute the dominant instability problem in present-day tokamaks. In this paper, the stability criteria for representative current profiles with q(0) values in the vicinity of unity are reviewed; sawtooth reconnection to q(0) values just at, or slightly exceeding, unity is generally destabilizing to the m = 2, n = 2 and m = 3, n = 2 modes and limits the range of stable profile shapes. Major disruptions can be produced by the simultaneous growth of m = 2, n = 1 and m = 3, n = 2 magnetic islands, leading to destabilization of higher-order modes and to the overlapping of several island chains. Internal disruptions---or sawteeth---arise in a variety of forms other than that produced by the classically reconnecting m = 1 mode. In some case, the q(r) value is apparently close to unity over a large central part of the plasma; in other cases, the q(0) value remains substantially below unity throughout a sawtooth cycle. Toroidal effects are sufficient to stabilize the resistive m = 1 mode in the latter case. Feedback stabilization of m ≥ 2 modes by rf heating or current drive, applied locally at the magnetic islands, appears feasible; feedback by island current drive is much more efficient, in terms of the radio-frequency power required, than feedback by island heating. Feedback stabilization of the m = 1 resistive mode---although yielding particularly beneficial effects for resistive-tearing and high-beta stability by allowing q(0) values substantially below unity---is more problematical, unless the m = 1 ideal MHD mode can be given sufficient positive stability. This appears possible, however, either by strong triangular shaping of the central flux surfaces or by appropriate tailoring of the current profile in the vicinity of the q = 1 surface

  9. Long-wavelength microinstabilities in toroidal plasmas

    International Nuclear Information System (INIS)

    Realistic kinetic toroidal eigenmode calculations have been carried out to support a proper assessment of the influence of long-wavelength microturbulence on transport in tokamak plasmas. In order to efficiently evaluate large-scale kinetic behavior extending over many rational surfaces, significant improvements have been made to a toroidal finite element code used to analyze the fully two-dimensional (r,θ) mode structures of trapped-ion and toroidal ion temperature gradient (ITG) instabilities. It is found that even at very long wavelengths, these eigenmodes exhibit a strong ballooning character with the associated radial structure relatively insensitive to ion Landau damping at the rational surfaces. In contrast to the long-accepted picture that the radial extent of trapped-ion instabilities is characterized by the ion-gyroradius-scale associated with strong localization between adjacent rational surfaces, present results demonstrate that under realistic conditions, the actual scale is governed by the large-scale variations in the equilibrium gradients. Applications to recent measurements of fluctuation properties in TFTR L-mode plasmas indicate that the theoretical trends appear consistent with spectral characteristics as well as rough heuristic estimates of the transport level. Benchmarking calculations in support of the development of a three-dimensional toroidal gyrokinetic code indicate reasonable agreement with respect to both the properties of the eigenfunctions and the magnitude of the eigenvalues during the linear phase of the simulations of toroidal ITG instabilities

  10. ORNL Levitated Toroidal Multipole Program

    International Nuclear Information System (INIS)

    We are studying confinement of gun-injected and microwave-produced plasmas in a levitated toroidal quadrupole in which internal hoop supports are not present to limit plasma confinement. Electromagnetic levitation is made possible by reducing the 60 Hz skin depth in the copper walls with liquid nitrogen cooling. The cooling also increases the magnetic field lifetime so that an e-folding time of 17 ms was measured after crowbarring. Computations indicate that in a properly designed, larger device, an e-folding time of 100 ms can be reached. Washer-gun hydrogen plasmas and Bostick-type lithium gun plasmas were injected into the levitated quadrupole with typical parameters: B ≥ 3 kG, Te ≈ 3 eV, ni ≈ 109 cm-3, and 1 i i ≈ 1010 cm-3, Te ≈ 30 eV, and τ/τBohm ≈ 30. Density fluctuations (Δn/n) in the region of good field curvature were less than 0.05 and in the region of bad curvature 0.10-0.25. With the removal of the magnetic well (by removing the inner hoop), τ/τBohm and ni each dropped a factor of 4 and Δn/n became greater than 0.25. Recent experiments using 200 W at λ = 3 cm have produced plasmas with higher densities (n > 1011 cm-3 assuming Te ≈ 100 eV), higher temperatures (Te ≈ 100 eV) and longer lifetimes (τ ≈ 80 μs ≈ 40 τBohm) than in the λ = 12 cm experiments. Detailed probe measurements of density and temperature are consistent with models for plasma behaviour based on computed magnetic field plots. Probe data show clear evidence of the changes in heating zones during the variation of the sinusoidal magnetic field and a large obstacle intercepting all flux lines effectively prevents the formation of the plasma. We are also studying a levitated helical hexapole, whose advantages over the quadrupole are a better ratio of connection length to radius of bad curvature and more confinement volume. (author)

  11. Superconducting toroid design for the ATLAS experiment at LHC

    International Nuclear Information System (INIS)

    The ATLAS Experiment proposed for LHC will use toroidal magnet systems to achieve high muon momentum resolution. The proposal is based on an air-cored superconducting toroid magnet system consisting of a long barrel toroid with a pair of end cap toroids to provide high resolution at large rapidity. Each end cap toroid will have an outer diameter of approximately 11m and an axis length of 5m and will provide field integrals in the range 4-8Tm over the rapidity span η = 1.5--2.8. This paper presents the magnetic, mechanical and cryogenic design of the end cap toroid magnet systems

  12. Tokamak with liquid metal for inducing toroidal electrical field

    Science.gov (United States)

    Ohkawa, Tihiro

    1981-01-01

    A tokamak apparatus includes a vessel for defining a reservoir and confining liquid therein. A toroidal liner disposed within said vessel defines a toroidal space within the liner confines gas therein. Liquid metal fills the reservoir outside the liner. A magnetic field is established in the liquid metal to develop magnetic flux linking the toroidal space. The gas is ionized. The liquid metal and the toroidal space are moved relative to one another transversely of the space to generate electric current in the ionized gas in the toroidal space about its major axis and thereby heat plasma developed in the toroidal space.

  13. A Classification Scheme For Toroidal Molecules

    CERN Document Server

    Berger, J; Berger, Jorge; Avron, Joseph E.

    1995-01-01

    We construct a class of periodic tilings of the plane, which corresponds to toroidal arrangements of trivalent atoms, with pentagonal, hexagonal and heptagonal rings. Each tiling is characterized by a set of four integers and determines a toroidal molecule. The tiling rules are motivated by geometric considerations and the tiling patterns are rich enough to describe a wide class of toroidal carbon molecules, with a broad range of shapes and numbers of atoms. The molecular dimensions are simply related to the integers that determine the tiling. The configurational energy and the delocalisation energy of several molecules obtained in this way were computed for Tersoff and H\\"uckel models. The results indicate that many of these molecules are not strained, and may be expected to be stable. We studied the influence of size on the H\\"{u}ckel spectrum: it bears both similarities and differences as compared with the case of tubules.

  14. Quasisymmetric toroidal plasmas with large mean flows

    International Nuclear Information System (INIS)

    Geometric condition for quasisymmetric toroidal plasmas with large mean flows on the order of the ion thermal speed are investigated. Equilibrium momentum balance equations including the inertia term due to the large flow velocity are used to show that, for rotating quasisymmetic plasmas with no local currents crossing flux surfaces, all components of the metric tensor should be independent of the toroidal angle in the Boozer coordinates, and consequently these systems need to be rigorously axisymmetric. Unless the local radial currents vanish, the Boozer coordinates do not exist and the toroidal flow velocity cannot take any value other than a very limited class of eigenvalues corresponding to very rapid rotation especially for low beta plasmas. (author)

  15. Toroidal high temperature superconducting coils for ISTTOK

    Energy Technology Data Exchange (ETDEWEB)

    Fernandes, H., E-mail: hf@ipfn.ist.utl.pt [Associacao Euratom/IST, Instituto de Plasmas e Fusao Nuclear, Laboratorio Associado, Instituto Superior Tecnico, 1049-001 Lisboa (Portugal); Goemoery, F. [Institute of Electrical Engineering, Slovak Academy of Sciences, Dubravska cesta 9, 84104 Bratislava (Slovakia); Corte, A. della; Celentano, G. [ENEA C.R. Frascati, Via E. Fermi 45, 00044 Frascati (Italy); Souc, J. [Institute of Electrical Engineering, Slovak Academy of Sciences, Dubravska cesta 9, 84104 Bratislava (Slovakia); Silva, C.; Carvalho, I.; Gomes, R. [Associacao Euratom/IST, Instituto de Plasmas e Fusao Nuclear, Laboratorio Associado, Instituto Superior Tecnico, 1049-001 Lisboa (Portugal); Di Zenobio, A.; Messina, G. [ENEA C.R. Frascati, Via E. Fermi 45, 00044 Frascati (Italy)

    2011-10-15

    High temperature superconductors (HTS) are very attractive to be used in fusion devices mainly due to lower operations costs. The HTS technology has reached a point where the construction of toroidal field coils for a tokamak is possible. The feasibility of a tokamak operating with HTS is extremely relevant and ISTTOK is the ideal candidate for a meaningful test due to its small size (and consequently lower cost) and the possibility to operate in a steady-state inductive regime. In this paper, a conceptual study of the ISTTOK upgrade to a superconducting device is presented, along with the relevant boundary conditions to achieve a permanent toroidal field with HTS. It is shown that the actual state of the art in HTS allows the design of a toroidal field coil capable of generating the appropriate field on plasma axis while respecting the structural specification of the machine.

  16. Toroidal high temperature superconducting coils for ISTTOK

    International Nuclear Information System (INIS)

    High temperature superconductors (HTS) are very attractive to be used in fusion devices mainly due to lower operations costs. The HTS technology has reached a point where the construction of toroidal field coils for a tokamak is possible. The feasibility of a tokamak operating with HTS is extremely relevant and ISTTOK is the ideal candidate for a meaningful test due to its small size (and consequently lower cost) and the possibility to operate in a steady-state inductive regime. In this paper, a conceptual study of the ISTTOK upgrade to a superconducting device is presented, along with the relevant boundary conditions to achieve a permanent toroidal field with HTS. It is shown that the actual state of the art in HTS allows the design of a toroidal field coil capable of generating the appropriate field on plasma axis while respecting the structural specification of the machine.

  17. Toroidal mode-conversion in the ICRF

    International Nuclear Information System (INIS)

    Mode-conversion is studied in the ion-cyclotron range of frequencies (ICRF) taking into account the toroidal geometry relevant for tokamaks. The global wavefields obtained using the gyrokinetic toroidal PENN code illustrate how the fast wave propagates to the neighborhood of the ion-ion hybrid resonance, where it is converted to a slow wave which deposits the wave energy through resonant interactions with the particles. The power deposition profiles obtained are dramatically different from the toroidal resonance absorption, showing that Budden's model is not a good approximation in the torus. Radially and poloidally localized wavefield structures characteristic of slow wave eigenmodes are predicted and could in experiments be driven to large amplitudes so as to interact efficiently with fast particles. (author) 5 figs., 1 tab., 48 refs

  18. Toroidal mode conversion in the ICRF

    International Nuclear Information System (INIS)

    Mode conversion is studied in the ion cyclotron range of frequencies (ICRF), taking into account the toroidal geometry relevant for tokamaks. The global wavefields obtained using the gyrokinetic toroidal PENN code illustrate how the fast wave propagates to the neighbourhood of the ion-ion hybrid resonance, where it is converted to a slow wave that deposits the wave energy through resonant Landau and cyclotron interactions with the particles. The power deposition profiles obtained are dramatically different from the toroidal resonance absorption, showing that Budden's fluid model is not a good approximation in the torus. Radially and poloidally localized wavefield structures characteristic of slow wave eigenmodes are predicted, which could be used in experiments to form transport barriers and to interact with fast particles. (author)

  19. Observation of Central Toroidal Rotation Induced by ICRF on EAST

    Science.gov (United States)

    Pan, Xiayun; Wang, Fudi; Zhang, Xinjun; Lyu, Bo; Chen, Jun; Li, Yingying; Fu, Jia; Shi, Yuejiang; Yu, Yi; Ye, Minyou; Wan, Baonian

    2016-02-01

    Core plasma rotation of both L-mode and H-mode discharges with ion cyclotron range of frequency (ICRF) minority heating (MH) scheme was measured with a tangential X-ray imaging crystal spectrometer on EAST (Experimental Advanced Superconducting Tokamak). Co-current central impurity toroidal rotation change was observed in ICRF-heated L- and H-mode plasmas. Rotation increment as high as 30 km/s was generated at ∼1.7 MW ICRF power. Scaling results showed similar trend as the Rice scaling but with significant scattering, especially in L-mode plasmas. We varied the plasma current, toroidal field and magnetic configuration individually to study their effect on L-mode plasma rotation, while keeping the other major plasma parameters and heating unchanged during the scanning. It was found that larger plasma current could induce plasma rotation more efficiently. A scan of the toroidal magnetic field indicated that the largest rotation was obtained for on-axis ICRF heating. A comparison between lower-single-null (LSN) and double-null (DN) configurations showed that LSN discharges rendered a larger rotation change for the same power input and plasma parameters. supported by the National Magnetic Confinement Fusion Science Program of China (Nos. 2013GB112004 and 2015GB103002), National Natural Science Foundation of China (Nos. 11175208, 11305212, 11375235, 11405212 and 11261140328), the Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology (2014FXCX003) and Brain Korea 21 Program for Leading Universities & Students (BK21 PLUS)

  20. Operational Experiences Tuning the ATF2 Final Focus Optics Towards Obtaining a 37nm Electron Beam IP Spot Size

    OpenAIRE

    White, G.; Seryi, A.; Woodley, M.; E. Marin; Kamiya, Y.; Bai, S.; Bolzon, B; Kubo, K.; Kuroda, S.; Okugi, T.; Tauchi, T.; Bambade, P.; Renier, Y.; Komamiya, S.; Oroku, M.

    2010-01-01

    The primary aim of the ATF2 research accelerator is to test a scaled version of the final focus optics planned for use in next-generation linear lepton colliders. ATF2 consists of a 1.3 GeV linac, damping ring providing low-emittance electron beams (

  1. Models for large superconducting toroidal magnet systems

    International Nuclear Information System (INIS)

    Prior to the design of large GJ toroidal magnet systems it is appropriate to procure small scale models, which can simulate their pertinent properties and allow to investigate their relevant phenomena. The important feature of the model is to show under which circumstances the system performance can be extrapolated to large magnets. Based on parameters such as the maximum magnetic field and the current density, the maximum tolerable magneto-mechanical stresses, a simple method of designing model magnets is presented. It is shown how pertinent design parameters are changed when the toroidal dimensions are altered. In addition some conductor cost estimations are given based on reactor power output and wall loading

  2. Toroidal Horizons in Binary Black Hole Mergers

    OpenAIRE

    Bohn, Andy; Kidder, Lawrence E.; Teukolsky, Saul A.

    2016-01-01

    We find the first binary black hole event horizon with a toroidal topology. It had been predicted that generically the event horizons of merging black holes should briefly have a toroidal topology, but such a phase has never been seen prior to this work. In all previous binary black hole simulations, in the coordinate slicing used to evolve the black holes, the topology of the event horizon transitions directly from two spheres during the inspiral to a single sphere as the black holes merge. ...

  3. Toroidal Precession as a Geometric Phase

    Energy Technology Data Exchange (ETDEWEB)

    J.W. Burby and H. Qin

    2012-09-26

    Toroidal precession is commonly understood as the orbit-averaged toroidal drift of guiding centers in axisymmetric and quasisymmetric configurations. We give a new, more natural description of precession as a geometric phase effect. In particular, we show that the precession angle arises as the holonomy of a guiding center's poloidal trajectory relative to a principal connection. The fact that this description is physically appropriate is borne out with new, manifestly coordinate-independent expressions for the precession angle that apply to all types of orbits in tokamaks and quasisymmetric stellarators alike. We then describe how these expressions may be fruitfully employed in numerical calculations of precession.

  4. Some properties of toroidal isodynamic magnetostatic equilibria

    Energy Technology Data Exchange (ETDEWEB)

    Aly, J.-J. [AIM, Unite Mixte de Recherche CEA, CNRS, Universite Paris VII, UMR no 7158, Centre d' Etudes de Saclay, F-91191 Gif sur Yvette Cedex (France)

    2011-09-15

    We establish some general properties of a 3D isodynamic magnetostatic equilibrium admitting a family of nested toroidal flux surfaces. In particular, we use the virial theorem to prove a simple relation between the total pressure (magnetic + thermal) and the magnetic pressure on each flux surface, and we derive some useful consequences of the latter. We also show the constancy on each rational surface of two integrals along magnetic lines. As a simple application of our results, we show the nonexistence of an equilibrium with vanishing toroidal current, and of an equilibrium with closed lines.

  5. Anomalous transport equations in toroidal plasmas

    International Nuclear Information System (INIS)

    Reduced transport equations for a toroidal plasma with fluctuations are derived. These equations include the effects of both anomalous and standard neoclassical transport, and allow clarification of the structure of convective fluxes caused by electrostatic and magnetic fluctuations. Special attention is paid to the combined effects of fluctuations and toroidicity on the transport. The formulation retains the effects of a magnetic field inhomogeneity on the anomalous transport. It is shown that phase space diffusion caused by the gradient in the equilibrium magnetic field appears as a pinch flux in the real space

  6. Optical spectroscopic analysis of compact toroids

    International Nuclear Information System (INIS)

    Time- and space-resolved plasma emission spectra from the Weapons Laboratory compact toroid (MARAUDER) experiment have been recorded using an optical multichannel analyzer (OMA). The OMA is optically coupled to the emitting plasmas using fiber optic cables. Results are presented in terms of the composition and purity of plasma species and ionization states for compact toroids formed of hydrogen and argon. The authors use relative line strengths with a collisional radiative equilibrium (CRE) model to estimate the plasma temperature and density. Electron density has also been determined from line profile analysis of the Hβ line in hydrogen

  7. THE FONT5 PROTOTYPE ILC INTRA-TRAIN FEEDBACK SYSTEM AT ATF2

    CERN Document Server

    Apsimon, R J; Burrows, P N; Christian, G B; Constance, B; Perry, C; Resta-Lopez, J

    2011-01-01

    We present the design and beam test results of a prototype beam-based digital feedback system for the Interaction Point of the International Linear Collider. A custom analogue front-end signal processor, FPGA-based digital signal processing boards, and kicker drive amplifier have been designed, built, deployed and tested with beam in the extraction line of the KEK Accelerator Test Facility (ATF2). The system was used to provide orbit correction to the train of bunches extracted from the ATF damping ring. The latency was measured to be approximately 140 ns.

  8. R and D status of the magnet system for ATF damping ring

    International Nuclear Information System (INIS)

    The ATF damping ring (DR) requires very strict conditions for the magnets system to realize a very low vertical normalized emittance less than 3x10-8 rm and a fast damping time. To obtain such a low emittance, the ATF-DR adopted a combined FOBO lattice and damping wigglers. Specifications of the magnet system have been almost fixed and some R and D magnets, which are a damping wiggler, a combined bending, quadrupoles and a sextupole magnet, have been manufactured and are waiting for precise field measurements. R and D status of these magnets are described. (author)

  9. Design of bunch compressing system with suppression of coherent synchrotron radiation for ATF upgrade

    Energy Technology Data Exchange (ETDEWEB)

    Jing, Yichao [Brookhaven National Lab. (BNL), Upton, NY (United States); Fedurin, Mikhail [Brookhaven National Lab. (BNL), Upton, NY (United States); Stratakis, Diktys [Brookhaven National Lab. (BNL), Upton, NY (United States)

    2015-05-03

    One of the operation modes for Accelerator Test Facility (ATF) upgrade is to provide high peak current, high quality electron beam for users. Such operation requires a bunch compressing system with a very large compression ratio. The CSR originating from the strong compressors generally could greatly degrade the quality of the electron beam. In this paper, we present our design for the entire bunch compressing system that will limit the effect of CSR on the e-beam’s quality. We discuss and detail the performance from the start to end simulation of such a compressor for ATF.

  10. The effect of sheared toroidal rotation on pressure driven magnetic islands in toroidal plasmas

    Science.gov (United States)

    Hegna, C. C.

    2016-05-01

    The impact of sheared toroidal rotation on the evolution of pressure driven magnetic islands in tokamak plasmas is investigated using a resistive magnetohydrodynamics model augmented by a neoclassical Ohm's law. Particular attention is paid to the asymptotic matching data as the Mercier indices are altered in the presence of sheared flow. Analysis of the nonlinear island Grad-Shafranov equation shows that sheared flows tend to amplify the stabilizing pressure/curvature contribution to pressure driven islands in toroidal tokamaks relative to the island bootstrap current contribution. As such, sheared toroidal rotation tends to reduce saturated magnetic island widths.

  11. The transcription factor ATF7 mediates lipopolysaccharide-induced epigenetic changes in macrophages involved in innate immunological memory.

    Science.gov (United States)

    Yoshida, Keisuke; Maekawa, Toshio; Zhu, Yujuan; Renard-Guillet, Claire; Chatton, Bruno; Inoue, Kentaro; Uchiyama, Takeru; Ishibashi, Ken-ichi; Yamada, Takuji; Ohno, Naohito; Shirahige, Katsuhiko; Okada-Hatakeyama, Mariko; Ishii, Shunsuke

    2015-10-01

    Immunological memory is thought to be mediated exclusively by lymphocytes. However, enhanced innate immune responses caused by a previous infection increase protection against reinfection, which suggests the presence of innate immunological memory. Here we identified an important role for the stress-response transcription factor ATF7 in innate immunological memory. ATF7 suppressed a group of genes encoding factors involved in innate immunity in macrophages by recruiting the histone H3K9 dimethyltransferase G9a. Treatment with lipopolysaccharide, which mimics bacterial infection, induced phosphorylation of ATF7 via the kinase p38, which led to the release of ATF7 from chromatin and a decrease in repressive histone H3K9me2 marks. A partially disrupted chromatin structure and increased basal expression of target genes were maintained for long periods, which enhanced resistance to pathogens. ATF7 might therefore be important in controlling memory in cells of the innate immune system. PMID:26322480

  12. CHAC1/MGC4504 is a novel proapoptotic component of the unfolded protein response, downstream of the ATF4-ATF3-CHOP cascade.

    Science.gov (United States)

    Mungrue, Imran N; Pagnon, Joanne; Kohannim, Omid; Gargalovic, Peter S; Lusis, Aldons J

    2009-01-01

    To understand pathways mediating the inflammatory responses of human aortic endothelial cells to oxidized phospholipids, we previously used a combination of genetics and genomics to model a coexpression network encompassing >1000 genes. CHAC1 (cation transport regulator-like protein 1), a novel gene regulated by ox-PAPC (oxidized 1-palmitoyl-2-arachidonyl-sn-3-glycero-phosphorylcholine), was identified in a co-regulated group of genes enriched for components of the ATF4 (activating transcription factor 4) arm of the unfolded protein response pathway. Herein, we characterize the role of CHAC1 and validate the network model. We first define the activation of CHAC1 mRNA by chemical unfolded protein response-inducers, but not other cell stressors. We then define activation of CHAC1 by the ATF4-ATF3-CHOP (C/EBP homologous protein), and not parallel XBP1 (X box-binding protein 1) or ATF6 pathways, using siRNA and/or overexpression plasmids. To examine the subset of genes downstream of CHAC1, we used expression microarray analysis to identify a list of 227 differentially regulated genes. We validated the activation of TNFRSF6B (tumor necrosis factor receptor superfamily, member 6b), a FASL decoy receptor, in cells treated with CHAC1 small interfering RNA. Finally, we showed that CHAC1 overexpression enhanced apoptosis, while CHAC1 small interfering RNA suppressed apoptosis, as determined by TUNEL, PARP (poly(ADP-ribose) polymerase) cleavage, and AIF (apoptosis-inducing factor) nuclear translocation. PMID:19109178

  13. New material equations for electromagnetism with toroid polarizations

    International Nuclear Information System (INIS)

    With regard to the toroid contributions, a modified system of equations of electrodynamics moving continuous media has been obtained. Alternative formalisms to introduce the toroid moment contributions in the equations of electromagnetism has been worked out. The two four-potential formalism has been developed. Lorentz transformation laws for the toroid polarizations has been given. Covariant form of equations of electrodynamics of continuous media with toroid polarizations has been written. (author)

  14. Coupling of Applied Non-axisymmetric Fields to Toroidal Torque

    Science.gov (United States)

    Logan, N. C.; Park, J.-K.; Menard, J. E.; Strait, E. J.; Paz-Soldan, C.; Lanctot, M. J.

    2014-10-01

    Recent advances in the modeling of neoclassical toroidal viscosity (NTV) have enabled realistic predictions of the coupling between applied non-axisymmetric fields and the resultant toroidal torque in the DIII-D tokamak. The strong dependence of the NTV on the amplified plasma kink response reduces the control of the non-resonant torque to a single mode model, in which the torque optimization is equivalent to an optimization of the net non-axisymmetric field's overlap with the spatial structure of the dominant mode. This single mode model has enabled efficient feed-forward correction of the n = 1 and n = 2 intrinsic error fields and n = 1-3 proxy error fields in NTV dominated scenarios. In addition, rotation drive toward a neoclassical offset using multiple coil sets has been optimized in accordance with the single mode model. Similar linear optimization techniques could be used to design future coil sets for rotation control, while inclusion of multimodal effects will be necessary for rotation profile control. Work supported by the US Department of Energy under DE-AC02-09CH11466 and DE-FC02-04ER54698.

  15. Trapped ion mode in toroidally rotating plasmas

    International Nuclear Information System (INIS)

    The influence of radially sheared toroidal flows on the Trapped Ion Mode (TIM) is investigated using a two-dimensional eigenmode code. These radially extended toroidal microinstabilities could significantly influence the interpretation of confinement scaling trends and associated fluctuation properties observed in recent tokamak experiments. In the present analysis, the electrostatic drift kinetic equation is obtained from the general nonlinear gyrokinetic equation in rotating plasmas. In the long perpendicular wavelength limit kτρbi much-lt 1, where ρbi is the average trapped-ion banana width, the resulting eigenmode equation becomes a coupled system of second order differential equations nmo for the poloidal harmonics. These equations are solved using finite element methods. Numerical results from the analysis of low and medium toroidal mode number instabilities are presented using representative TFTR L-mode input parameters. To illustrate the effects of mode coupling, a case is presented where the poloidal mode coupling is suppressed. The influence of toroidal rotation on a TFTR L-mode shot is also analyzed by including a beam species with considerable larger temperature. A discussion of the numerical results is presented

  16. ATLAS Barrel Toroid magnet reached nominal field

    CERN Multimedia

    2006-01-01

     On 9 November the barrel toroid magnet reached its nominal field of 4 teslas, with an electrical current of 21 000 amperes (21 kA) passing through the eight superconducting coils as shown on this graph

  17. Celebration for the ATLAS Barrel Toroid magnet

    CERN Multimedia

    2007-01-01

    Representatives from Funding Agencies and Barrel Toroid Magnet Laboratories during the ceremony. From left to right: Jean Zinn-Justin (Head of DAPNIA/CEA/Saclay), CERN Director-General Robert Aymar, and Roberto Petronzio (President INFN).Allan Clark (DPNC University Geneva) and Enrique Fernandez (IFAE Barcelona) were among the guests visiting the ATLAS cavern. The barrel toroid is visible in the background. A celebration took place at Point 1 on 13 December to toast the recent powering-up of the ATLAS barrel toroid magnet to full field (Bulletin No. 47-48/06). About 70 guests were invited to attend, mainly composed of representatives from funding partners and key members of the laboratory management teams of the barrel toroid magnet, representing CEA France, INFN Italy, BMBF Germany, Spain, Sweden, Switzerland, Russia, JINR Dubna and CERN. An introductory speech by ATLAS spokesperson Peter Jenni the scene for evening. This was followed by the ATLAS magnet system project leader Herman Ten Kate's account of the...

  18. ATLAS: Full power for the toroid magnet

    CERN Multimedia

    2006-01-01

    The 9th of November was a memorable day for ATLAS. Just before midnight, the gigantic Barrel toroid magnet reached its nominal field of 4 teslas in the coil windings, with an electrical current of 21000 amperes (21 kA) passing through the eight superconducting coils (as seen on the graph). This achievement was obtained after several weeks of commissioning. The ATLAS Barrel Toroid was first cooled down for about six weeks in July-August to -269°C (4.8 K) and then powered up step-by-step in successive test sessions to 21 kA. This is 0.5 kA above the current required to produce the nominal magnetic field. Afterwards, the current was safely switched off and the stored magnetic energy of 1.1 gigajoules was dissipated in the cold mass, raising its temperature to a safe -218°C (55 K). 'We can now say that the ATLAS Barrel Toroid is ready for physics,' said Herman ten Kate, project leader for the ATLAS magnet system. The ATLAS barrel toroid magnet is the result of a close collaboration between the magnet la...

  19. Reduced Magnetohydrodynamic Equations in Toroidal Geometry

    Institute of Scientific and Technical Information of China (English)

    REN Shen-Ming; YU Guo-Yang

    2001-01-01

    By applying a new assumption of density, I.e. R2 p = const, the continuity equation is satisfied to the order ofe2`+with e being the inverse aspect ratio. In the case of large aspect ratio, a set of reduced magnetohydrodynamicequations in toroidal geometry are obtained. The new assumption about the density is supported by experimentalobservation to some extent.

  20. Chiral Anomaly in Toroidal Carbon Nanotubes

    OpenAIRE

    Sasaki, K.

    2001-01-01

    It is pointed out that the chiral anomaly in 1+1 dimensions should be observed in toroidal carbon nanotubes on a planar geometry with varying magnetic field. We show that the chiral anomaly is closely connected with the persistent current in a one-dimensional metallic ring.

  1. Toroidal groups line bundles, cohomology and quasi-Abelian varieties

    CERN Document Server

    Kopfermann, Klaus

    2001-01-01

    Toroidal groups are the connecting link between torus groups and any complex Lie groups. Many properties of complex Lie groups such as the pseudoconvexity and cohomology are determined by their maximal toroidal subgroups. Quasi-Abelian varieties are meromorphically separable toroidal groups. They are the natural generalisation of the Abelian varieties. Nevertheless, their behavior can be completely different as the wild groups show.

  2. On the stabilization of toroidal pinches by finite larmor radius effects and toroidal magnetic field

    International Nuclear Information System (INIS)

    The radial eigenvalue problem for internal modes in a large aspect ratio toriodal pinch has been solved. A particularly stable regime for a weak but nonzero toroidal magnetic field has been found. (31 refs.)

  3. Analysis of spiky net toroidal current in the magnetized toroidal plasma from the point of view of helicity conservation

    International Nuclear Information System (INIS)

    It has been observed that 'runaway oscillations' in the toroidal current of the magnetized resistive toroidal plasma may cause continuous tearing activity, resulting in 'spiky' net toroidal current and modulation of toroidal and poloidal magnetic fields of the plasma with a definite phase relationship, depending upon the magnitude of vertical magnetic field. The present experimental results on current decay and recovery are explained from the point of view of helicity conservation. (author)

  4. Dynamical model for the toroidal sporadic meteors

    Energy Technology Data Exchange (ETDEWEB)

    Pokorný, Petr; Vokrouhlický, David [Institute of Astronomy, Charles University, V Holešovičkách 2, CZ-18000 Prague 8 (Czech Republic); Nesvorný, David [Department of Space Studies, Southwest Research Institute, 1050 Walnut Street, Suite 300, Boulder, CO 80302 (United States); Campbell-Brown, Margaret; Brown, Peter, E-mail: petr.pokorny@volny.cz, E-mail: vokrouhl@cesnet.cz, E-mail: davidn@boulder.swri.edu, E-mail: margaret.campbell@uwo.ca, E-mail: pbrown@uwo.ca [Department of Physics and Astronomy, University of Western Ontario, London, ON N6A 3K7 (Canada)

    2014-07-01

    More than a decade of radar operations by the Canadian Meteor Orbit Radar have allowed both young and moderately old streams to be distinguished from the dispersed sporadic background component. The latter has been categorized according to broad radiant regions visible to Earth-based observers into three broad classes: the helion and anti-helion source, the north and south apex sources, and the north and south toroidal sources (and a related arc structure). The first two are populated mainly by dust released from Jupiter-family comets and new comets. Proper modeling of the toroidal sources has not to date been accomplished. Here, we develop a steady-state model for the toroidal source of the sporadic meteoroid complex, compare our model with the available radar measurements, and investigate a contribution of dust particles from our model to the whole population of sporadic meteoroids. We find that the long-term stable part of the toroidal particles is mainly fed by dust released by Halley type (long period) comets (HTCs). Our synthetic model reproduces most of the observed features of the toroidal particles, including the most troublesome low-eccentricity component, which is due to a combination of two effects: particles' ability to decouple from Jupiter and circularize by the Poynting-Robertson effect, and large collision probability for orbits similar to that of the Earth. Our calibrated model also allows us to estimate the total mass of the HTC-released dust in space and check the flux necessary to maintain the cloud in a steady state.

  5. An FPGA-based Bunch-by-Bunch Position and Angle Feedback System at ATF2

    CERN Document Server

    Christian, G B; Bett, D R; Burrows, P N; Constance, B; Davis, M R; Gerbershagen, A; Perry, C; Resta Lopez, J

    2011-01-01

    The FONT5 intra-train feedback system serves as a prototype for an interaction point beam-based feedback system for future electron-positron colliders, such as the International Linear Collider. The system has been tested on the KEK Accelerator Test Facility (ATF) and is deployed to stabilise the beam orbit at the ATF2. The goal of this system is to correct both position and angle jitter in the vertical plane, providing stability of ~1 micron at the entrance to the ATF2 final-focus system. The system comprises three stripline beam position monitors (BPMs) and two stripline kickers, custom low-latency analogue front-end BPM processors, a custom FPGA-based digital processing board with fast ADCs, and custom kicker-drive amplifiers. An overview of the hardware, and the latest results from beam tests at ATF2, will be presented. The total latency of the system with coupled position and angle feedback loops operating simultaneously was measured to be approximately 140 ns. The greatest degree of correction observed ...

  6. Tumor suppressor BTG1 promotes PRMT1-mediated ATF4 function in response to cellular stress

    Science.gov (United States)

    Tijchon, Esther; van Ingen Schenau, Dorette; van Emst, Liesbeth; Levers, Marloes; Palit, Sander A.L.; Rodenbach, Caroline; Poelmans, Geert; Hoogerbrugge, Peter M.; Shan, Jixiu; Kilberg, Michael S.; Scheijen, Blanca; van Leeuwen, Frank N.

    2016-01-01

    Cancer cells are frequently exposed to physiological stress conditions such as hypoxia and nutrient limitation. Escape from stress-induced apoptosis is one of the mechanisms used by malignant cells to survive unfavorable conditions. B-cell Translocation Gene 1 (BTG1) is a tumor suppressor that is frequently deleted in acute lymphoblastic leukemia and recurrently mutated in diffuse large B cell lymphoma. Moreover, low BTG1 expression levels have been linked to poor outcome in several solid tumors. How loss of BTG1 function contributes to tumor progression is not well understood. Here, using Btg1 knockout mice, we demonstrate that loss of Btg1 provides a survival advantage to primary mouse embryonic fibroblasts (MEFs) under stress conditions. This pro-survival effect involves regulation of Activating Transcription Factor 4 (ATF4), a key mediator of cellular stress responses. We show that BTG1 interacts with ATF4 and positively modulates its activity by recruiting the protein arginine methyl transferase PRMT1 to methylate ATF4 on arginine residue 239. We further extend these findings to B-cell progenitors, by showing that loss of Btg1 expression enhances stress adaptation of mouse bone marrow-derived B cell progenitors. In conclusion, we have identified the BTG1/PRMT1 complex as a new modifier of ATF4 mediated stress responses. PMID:26657730

  7. Development of compact toroids injector for direct plasma controls

    International Nuclear Information System (INIS)

    The application of the compact toroids injector for direct plasma controls has been investigated. The compact toroids injection can fuel particles directly into the core of the plasma and modify the plasma profiles at the desired locations. The acceleration tests of the compact toroids have been conducted at Himeji Institute of Technology. The tests showed that the hydrogen compact toroid was accelerated up to 80km/s and the plasma density of the compact toroid was compressed to 1.2 x 1021m-3. (orig.)

  8. The transcription factor ATF3 is upregulated during chondrocyte differentiation and represses cyclin D1 and A gene transcription

    Directory of Open Access Journals (Sweden)

    James Claudine G

    2006-09-01

    Full Text Available Abstract Background Coordinated chondrocyte proliferation and differentiation are required for normal endochondral bone growth. Transcription factors binding to the cyclicAMP response element (CRE are known to regulate these processes. One member of this family, Activating Tanscription Factor 3 (ATF3, is expressed during skeletogenesis and acts as a transcriptional repressor, but the function of this protein in chondrogenesis is unknown. Results Here we demonstrate that Atf3 mRNA levels increase during mouse chondrocyte differentiation in vitro and in vivo. In addition, Atf3 mRNA levels are increased in response to cytochalasin D treatment, an inducer of chondrocyte maturation. This is accompanied by increased Atf3 promoter activity in cytochalasin D-treated chondrocytes. We had shown earlier that transcription of the cell cycle genes cyclin D1 and cyclin A in chondrocytes is dependent on CREs. Here we demonstrate that overexpression of ATF3 in primary mouse chondrocytes results in reduced transcription of both genes, as well as decreased activity of a CRE reporter plasmid. Repression of cyclin A transcription by ATF3 required the CRE in the cyclin A promoter. In parallel, ATF3 overexpression reduces the activity of a SOX9-dependent promoter and increases the activity of a RUNX2-dependent promoter. Conclusion Our data suggest that transcriptional induction of the Atf3 gene in maturing chondrocytes results in down-regulation of cyclin D1 and cyclin A expression as well as activation of RUNX2-dependent transcription. Therefore, ATF3 induction appears to facilitate cell cycle exit and terminal differentiation of chondrocytes.

  9. The Segmented Bifilar Contrawound Toroidal Helical Antenna.

    Science.gov (United States)

    Vanvoorhies, Kurt Louis

    The segmented bifilar contrawound toroidal helical antenna, a.k.a. QuadContra antenna creates a toroidal magnetic current whose radiated electromagnetic fields emulate those of an electric dipole located normal to the plane of the toroidal helix. This antenna is a magnetic dual of the constant current electric loop antenna. Its principal advantages of reduced size and low profile result from both its circular geometry and from the velocity factor of its slow wave contrawound helical structure. This antenna is constructed by winding two conductors in contrawound relation to each other on a toroidal form, dividing the winding into an even number of segments, and reversing the pitch sense of each conductor from one segment to another. Feed ports are located on the conductors at the segment boundaries, and are connected in alternate phase to a central signal terminal via balanced and tuned transmission line elements. At resonance, each winding segment supports a quarter-wave sinusoidal current distribution. Toroidal electric current components are canceled, and poloidal current components are enhanced in the resulting anti-symmetric mode current distribution. This study measured and simulated the velocity factor, input impedance, bandwidth and simulated the radiation gain and pattern for a variety of linear and toroidal structures. The velocity factor, modeled as a power function of the ratio of axial winding length to wire length, was two to three times slower for the anti-symmetric mode contrawound helix than for a comparable monofilar helix. The radiation characteristics of the antenna were simulated using the OSU ESP4 Moment Method based program, after making extensive improvements to accommodate a wide variety of antenna configurations and to automatically find resonant frequencies. The simulated QuadContra antenna radiates with vertically polarization in a dipole-like pattern having a gain about 2 dB less than the dipole. The gain falls off dramatically for

  10. ATF3 upregulation in glia during Wallerian degeneration: differential expression in peripheral nerves and CNS white matter

    Directory of Open Access Journals (Sweden)

    Coffin Robert S

    2004-03-01

    Full Text Available Abstract Background Many changes in gene expression occur in distal stumps of injured nerves but the transcriptional control of these events is poorly understood. We have examined the expression of the transcription factors ATF3 and c-Jun by non-neuronal cells during Wallerian degeneration following injury to sciatic nerves, dorsal roots and optic nerves of rats and mice, using immunohistochemistry and in situ hybridization. Results Following sciatic nerve injury – transection or transection and reanastomosis – ATF3 was strongly upregulated by endoneurial, but not perineurial cells, of the distal stumps of the nerves by 1 day post operation (dpo and remained strongly expressed in the endoneurium at 30 dpo when axonal regeneration was prevented. Most ATF3+ cells were immunoreactive for the Schwann cell marker, S100. When the nerve was transected and reanastomosed, allowing regeneration of axons, most ATF3 expression had been downregulated by 30 dpo. ATF3 expression was weaker in the proximal stumps of the injured nerves than in the distal stumps and present in fewer cells at all times after injury. ATF3 was upregulated by endoneurial cells in the distal stumps of injured neonatal rat sciatic nerves, but more weakly than in adult animals. ATF3 expression in transected sciatic nerves of mice was similar to that in rats. Following dorsal root injury in adult rats, ATF3 was upregulated in the part of the root between the lesion and the spinal cord (containing Schwann cells, beginning at 1 dpo, but not in the dorsal root entry zone or in the degenerating dorsal column of the spinal cord. Following optic nerve crush in adult rats, ATF3 was found in some cells at the injury site and small numbers of cells within the optic nerve displayed weak immunoreactivity. The pattern of expression of c-Jun in all types of nerve injury was similar to that of ATF3. Conclusion These findings raise the possibility that ATF3/c-Jun heterodimers may play a role in

  11. ATF3 Mediates Anti-Cancer Activity of Trans-10, cis-12-Conjugated Linoleic Acid in Human Colon Cancer Cells

    OpenAIRE

    Kim, Kui-Jin; Lee, Jihye; Park, Yeonhwa; Lee, Seong-Ho

    2015-01-01

    Conjugated linoleic acids (CLA) are a family of isomers of linoleic acid. CLA increases growth arrest and apoptosis of human colorectal cancer cells through an isomer-specific manner. ATF3 belongs to the ATF/CREB family of transcription factors and is associated with apoptosis in colorectal cancer. The present study was performed to investigate the molecular mechanism by which t10, c12-CLA stimulates ATF3 expression and apoptosis in human colorectal cancer cells. t10, c12-CLA increased an apo...

  12. ATF4 mediation of NF1 functions in osteoblast reveals a nutritional basis for congenital skeletal dysplasiae

    OpenAIRE

    Elefteriou, Florent; Benson, M. Douglas; Sowa, Hideaki; Starbuck, Michael; Liu, Xiuyun; Ron, David; Parada, Luis F.; Karsenty, Gerard

    2006-01-01

    The transcription factor ATF4 enhances bone formation by favoring amino acid import and collagen synthesis in osteoblasts, a function requiring its phosphorylation by RSK2, the kinase inactivated in Coffin-Lowry Syndrome. Here, we show that in contrast, RSK2 activity, ATF4-dependent collagen synthesis, and bone formation are increased in mice lacking neurofibromin in osteoblasts (Nf1ob−/− mice). Independently of RSK2, ATF4 phosphorylation by PKA is enhanced in Nf1ob−/− mice, thereby increasin...

  13. Activating transcription factor-3 (ATF3) functions as a tumor suppressor in colon cancer and is up-regulated upon heat-shock protein 90 (Hsp90) inhibition

    International Nuclear Information System (INIS)

    Activating transcription factor-3 (ATF3) is involved in the complex process of cellular stress response. However, its exact role in cancer is discussed controversially because both tumor suppressive and oncogenic effects have been described. Here we followed-up on our previous observation that inhibition of Hsp90 may increase ATF3 expression and sought to determine the role of ATF3 in colon cancer. Regulation of ATF3 was determined in cancer cells using signaling inhibitors and a heat-shock protein-90 (Hsp90) antagonist. Human HCT116 cancer cells were stably transfected with an ATF3-shRNA or a luciferase-shRNA expression plasmid and alterations in cell motility were assessed in migration assays. The impact of ATF3 down-regulation on cancer growth and metastasis were investigated in a subcutaneous tumor model, a model of hepatic tumor growth and in a model of peritoneal carcinomatosis. Human colon cancer tissues were analyzed for ATF3 expression. The results show that therapeutic Hsp90 inhibition substantially up-regulates the expression of ATF3 in various cancer cells, including colon, gastric and pancreatic cancer. This effect was evident both in vitro and in vivo. RNAi mediated knock-down of ATF3 in HCT116 colon cancer cells significantly increased cancer cell migration in vitro. Moreover, in xenogenic mouse models, ATF3 knock-down promoted subcutaneous tumor growth and hepatic metastasis, as well as peritoneal carcinomatosis. Importantly, ATF3 expression was lower in human colon cancer specimens, as compared to corresponding normal surrounding tissues, suggesting that ATF3 may represent a down-regulated tumor suppressor in colon cancer. In conclusion, ATF3 down-regulation in colon cancer promotes tumor growth and metastasis. Considering that blocking Hsp90 induces ATF3 expression, Hsp90 inhibition may represent a valid strategy to treat metastatic colon cancer by up-regulating this anti-metastatic transcription factor

  14. Muon dynamics in a toroidal sector magnet

    International Nuclear Information System (INIS)

    The present scenario for the cooling channel in a high brightness muon collider calls for a quasi-continuous solenoidal focusing channel. The beam line consists of a periodic array of hydrogen absorbers immersed in a solenoid with alternating focusing field and rf linacs at the zero field points. Solenoids and toroidal sectors have a natural place in muon collider design given the large emittance of the beam and consequently, the large transverse momentum of the initial pion beam or the decay muon beam. Bent solenoids as shown were studied for use at the front end of the machine, as part of the capture channel and more recently as part of a diagnostic setup to measure the position and momentum of muons. The authors present a Hamiltonian formulation of muon dynamics in toroidal sector solenoids (bent solenoid)

  15. Anomalous transport theory for toroidal helical plasmas

    International Nuclear Information System (INIS)

    Anomalous transport coefficients in toroidal helical plasmas are studied, based on the innovative theoretical method. The self-sustained turbulence is analyzed by balancing the nonlinear growth due to the current diffusivity with the nonlinear damping by the ion viscosity and thermal conductivity. Interchange and ballooning mode turbulence is investigated, and the geometrical dependence of the anomalous transport coefficient is clarified. Variation of transport owing to the geometrical difference in toroidal helical plasmas is illustrated. The mechanism for confinement improvement is searched for. To verify the nonlinear destabilization and the self-sustained state, the nonlinear simulation of the interchange mode turbulence is performed in a sheared slab. It is demonstrated that the nonlinear enhancement of the growth rate occurs when the fluctuation amplitude exceeds the critical level. In the saturation stage, the fluctuation level becomes higher associated with the enhanced nonlinear growth. (author)

  16. Diffusiophoresis of a charged toroidal polyelectrolyte.

    Science.gov (United States)

    Tseng, Shiojenn; Hsu, Yen-Rei; Hsu, Jyh-Ping

    2016-06-01

    Considering recent application of concentration driven motion of charged nanoparticles in sensing technology, we model the diffusiophoresis of an isolated toroidal polyelectrolyte (PE) for the first time. Choosing an aqueous KCl solution for illustration, its behavior under various conditions is simulated by varying the double layer thickness, the size of toroid, and its softness and fixed charge density. We show that the behavior of the present PE can be different both quantitatively and qualitatively from that of the corresponding spherical PE. This arises from the competition of the hydrodynamic force and the electric force acting on a PE. The geometry and the nature of a PE can also influence appreciably its behavior, yielding complicated and interesting results. PMID:26970033

  17. Antimicrobial Peptides in Toroidal and Cylindrical Pores

    OpenAIRE

    Mihajlovic, Maja; Lazaridis, Themis

    2010-01-01

    Antimicrobial peptides (AMPs) are small, usually cationic peptides, which permeabilize biological membranes. Their mechanism of action is still not well understood. Here we investigate the preference of alamethicin and melittin for pores of different shapes, using molecular dynamics (MD) simulations of the peptides in pre-formed toroidal and cylindrical pores. When an alamethicin hexamer is initially embedded in a cylindrical pore, at the end of the simulation the pore remains cylindrical or ...

  18. Kinetic Damping of Toroidal Alfven Eigenmodes

    Energy Technology Data Exchange (ETDEWEB)

    G.Y. Fu; H.L. Berk; A. Pletzer

    2005-05-03

    The damping of Toroidal Alfven Eigenmodes in JET plasmas is investigated by using a reduced kinetic model. Typically no significant damping is found to occur near the center of the plasma due to mode conversion to kinetic Alfven waves. In contrast, continuum damping from resonance near the plasma edge may be significant, and when it is, it gives rise to damping rates that are compatible with the experimental observations.

  19. Toroidal geometry subroutines for MORSE-CG

    International Nuclear Information System (INIS)

    The equations, coding, and procedures that are required to include a torus in the Combinatorial Geometry subroutines of the MORSE-CG code are described. The derivation and solutions of the quartic equation that describes a torus along with additional subroutines and the modifications to existing subroutines required to carry out the transport of neutrons and gamma rays in toroidal geometry are presented. The input requirements and a sample problem are included

  20. Stellarator approach to toroidal plasma confinement

    International Nuclear Information System (INIS)

    An overview is presented of the development and current status of the stellarator approach to controlled thermonuclear confinement. Recent experimental, theoretical, and systems developments have made this concept a viable option for the evolution of the toroidal confinement program. Some experimental study of specific problems associated with departure from two-dimensional symmetry must be undertaken before the full advantages and opportunities of steady-state, net-current-free operation can be realized

  1. Aspects of Tokamak toroidal magnet protection

    Energy Technology Data Exchange (ETDEWEB)

    Green, R.W.; Kazimi, M.S.

    1979-07-01

    Simple but conservative geometric models are used to estimate the potential for damage to a Tokamak reactor inner wall and blanket due to a toroidal magnet field collapse. The only potential hazard found to exist is due to the MHD pressure rise in a lithium blanket. A survey is made of proposed protection methods for superconducting toroidal magnets. It is found that the two general classifications of protection methods are thermal and electrical. Computer programs were developed which allow the toroidal magnet set to be modeled as a set of circular filaments. A simple thermal model of the conductor was used which allows heat transfer to the magnet structure and which includes the effect of temperature dependent properties. To be effective in large magnets an electrical protection system should remove at least 50% of the stored energy in the protection circuit assuming that all of the superconductor in the circuit quenches when the circuit is activated. A protection system design procedure based on this criterion was developed.

  2. Toroidal rotation and halo current produced by disruptions

    Science.gov (United States)

    Strauss, Henry; Sugiyama, Linda; Paccagnella, Roberto; Breslau, Joshua; Jardin, Stephen

    2013-10-01

    In several experiments including JET, it was observed that disruptions were accompanied by toroidal rotation. There is a concern that there may be a resonance between rotating toroidal perturbations and the resonant frequencies of the ITER vacuum vessel, causing enhanced damage. MHD simulations with M3D demonstrate that disruptions produce toroidal rotation. The toroidal velocity can produce several rotations of the sideways force during a disruption. Edge localized modes (ELMs) also produce poloidal and toroidal rotation. A theory of rotation produced by MHD activity will be presented. In the case of ELMs, the theory gives toroidal rotation Alfven Mach number, Mϕ ~10-2βN . This is consistent with a scaling for intrinsic toroidal rotation in H mode tokamaks. It was also discovered on JET that disruptions were accompanied by toroidal variation of the plasma current Iϕ. From ∇ . j = 0 , the toroidal current variation ΔIϕ is proportional to the 3D halo current, ∮Jn Rdl , where Jn is the normal current density at the wall. The 3D halo current is calculated analytically and computationally. A bound on ΔIϕ /Iϕ is found, proportional to the halo current fraction and toroidal peaking factor. Supported by USDOE and ITER.

  3. Design status of the NET toroidal coils

    International Nuclear Information System (INIS)

    The Toroidal Field Coil System consists of 16 superconducting coil windings, their coil casings and the intercoil structure. All of these components are located inside a common cryostat vessel and will therefore be at a temperature of about 4.50 degK during operation of the machine. The 16 coils are arranged in a toroidal configuration in order to provide a magnetic field for the confinement of the ring shaped plasma. The inner legs of the D-shaped coils form a vault which is subjected to the centering forces that are caused by the toroidal field itself. The interaction between the poloidal field and the toroidal currents creates Lorentz Forces which are perpendicular to the TF coil plane. Intercoil structure and vault have to resist these forces. The huge size of the coils in combination with the fact that an A15 conductor material has to be used require techniques that are somewhat beyond the present state of the art. Therefore, a conductor and magnet development program has been launched. The development studies carried out by Associated Laboratories in cooperation with NET Team have resulted in several flow cooled composite conductors. Futheron, full size conductor samples were manufactured and two subsize conductors were manufactured and wound into two 12 T model coils. Proposals for the manufacture of the coil winding, the power supply and quench protection system, the cooling system and the instrumentation have been worked out in the course of these studies. To ensure the feasibility of the cois two study contracts have been placed with industry. This report will stress the most difficult aspects of the coil manufacture, the assembly of the winding in its steel casing and the assembly of the 16 coils with the intercoil structure to a toroidal configuration. The results of the thermomechanical and electromagnetic analysis (e.g. eddy currents in coils case, stress, a.c. losses) - will be reported and their impact on the design of the TF system will be

  4. Analysis of Turn-by-Turn Orbit Data and Dynamic Aperture Considerations for the ATF Damping Ring

    CERN Document Server

    Schmidt, F; Hayano, H; Kubo, K; Terunuma, N; Urakawa, J

    1999-01-01

    We describe an attempt to deduce the tune shift with amplitude and resonance driving terms for the ATF Damping Ring from turn-by-turn orbit data, and to compare measurement results with tracking simulations. Our analysis reveals a significant tune ripple, but no evidence for low-order nonlinearities. We thus conjecture that the ATF dynamic aperture is caused by a conspiracy of tune ripple and as yet unidentified higher-order nonlinear fields.

  5. Scoping assessments of ATF impact on late-stage accident progression including molten core-concrete interaction

    Science.gov (United States)

    Farmer, M. T.; Leibowitz, L.; Terrani, K. A.; Robb, K. R.

    2014-05-01

    Simple scoping models that can be used to evaluate ATF performance under severe accident conditions have been developed. The methodology provides a fundamental technical basis (a.k.a. metric) based on the thermodynamic boundary for evaluating performance relative to that of traditional Zr-based claddings. The initial focus in this study was on UO2 fuel with the advanced claddings 310 SS, D9, FeCrAl, and SiC. The evaluation considered only energy release with concurrent combustible gas production from fuel-cladding-coolant interactions and, separately, molten core-concrete interactions at high temperatures. Other important phenomenological effects that can influence the rate and extent of cladding decomposition (e.g., eutectic interactions, degradation of other core constituents) were not addressed. For the cladding types addressed, potential combustible gas production under both in-vessel and ex-vessel conditions was similar to that for Zr. However, exothermic energy release from cladding oxidation was substantially less for iron-based alloys (by at least a factor of 4), and modestly less (by ∼20%) for SiC. Data on SiC-clad UO2 fuel performance under severe accident conditions are sparse in the literature; thus, assumptions on the nature of the cladding decomposition process were made in order to perform this initial screening evaluation. Experimental data for this system under severe accident conditions is needed for a proper evaluation and comparison to iron-based claddings.

  6. Scoping assessments of ATF impact on late-stage accident progression including molten core–concrete interaction

    International Nuclear Information System (INIS)

    Simple scoping models that can be used to evaluate ATF performance under severe accident conditions have been developed. The methodology provides a fundamental technical basis (a.k.a. metric) based on the thermodynamic boundary for evaluating performance relative to that of traditional Zr-based claddings. The initial focus in this study was on UO2 fuel with the advanced claddings 310 SS, D9, FeCrAl, and SiC. The evaluation considered only energy release with concurrent combustible gas production from fuel–cladding–coolant interactions and, separately, molten core–concrete interactions at high temperatures. Other important phenomenological effects that can influence the rate and extent of cladding decomposition (e.g., eutectic interactions, degradation of other core constituents) were not addressed. For the cladding types addressed, potential combustible gas production under both in-vessel and ex-vessel conditions was similar to that for Zr. However, exothermic energy release from cladding oxidation was substantially less for iron-based alloys (by at least a factor of 4), and modestly less (by ∼20%) for SiC. Data on SiC-clad UO2 fuel performance under severe accident conditions are sparse in the literature; thus, assumptions on the nature of the cladding decomposition process were made in order to perform this initial screening evaluation. Experimental data for this system under severe accident conditions is needed for a proper evaluation and comparison to iron-based claddings

  7. Parameters Optimization for a Novel Vacuum Laser Acceleration Test at BNL-ATF

    CERN Document Server

    Shao, Lei; Zhou, Feng

    2005-01-01

    This paper presents a new VLA theory model which has revealed that the injection electrons with low energy and small incident angle relative to the laser beam are captured and significantly accelerated in a strong laser field. For the further step for verifying the novel-VLA mechanics, we propose to use the BNL-ATF Terawatt CO2 laser and a high-brightness electron beam to carry out a proof-of-principle beam experiment. Experiment setup including the laser injection optics and electron extraction system and beam diagnostics is presented. Extensive optimized simulation results with ATF practical parameters are also presented, which shows that even when the laser intensity is not very high, the net energy gain still can be seen obviously. This could be prospect for a new revolution of vacuum laser acceleration.

  8. 1.54 GeV ATF damping ring injector linear accelerator

    International Nuclear Information System (INIS)

    The Accelerator Test Facility (ATF) is under construction in the TRISTAN Assembly Hall to produce multi-bunch of electrons with ultra-low beam emittance. The ATF consists of a 1.54 GeV linac, beam transport line, 1.54 GeV damping ring, bunch compressor, final focus system and positron target test-stand. The 1.54 GeV linac consists of a low energy injector linac, accelerating linac and energy compensation system. The accelerating gradient of 33 MeV/m is produced at 200 MW input power. The 1.54 GeV linac accelerates 20 bunches of electrons with bunch separation of 2.8 ns. The accelerating structures, beam monitors and Q-magnets are aligned within ± 100 μm by active alignment system. The energy spectrum of multi-bunch is compressed to ± 0.16% by the energy compensation system. (author)

  9. Button-type beam-position monitor for the ATF damping ring

    International Nuclear Information System (INIS)

    Button-type beam-position monitors (BPMs) were fabricated for the ATF damping ring. The BPM was designed to achieve a position resolution of less than 5 μm; fabrication of the first 40 BPMs has been completed. For this BPM, a beam test was carried out at the 80-MeV injector part of the ATF LINAC. All of the bunch signals in the multi-bunch beam were clearly observed without any discharge. A calibration of the BPMs was also performed in order to check their offset from the electrical center to the mechanical center as well as their position detection sensitivity. The result shows good uniformity in position detection. (author)

  10. 1.54 GeV ATF injector linac for JLC

    International Nuclear Information System (INIS)

    The Accelerator Test Facility (ATF) is under construction in the TRISTAN Assembly Hall to produce multi-bunch electrons with vertical emittance of 3x10-8 mrad. The ATF consists of a 1.54 GeV injector linac, beam transport line, 1.54 GeV damping ring, bunch compressor, final focus system and positron target test-stand. The injector linac consists of a 80 MeV pre-injector linac, accelerating linac and energy compensation system. The accelerating gradient of 33 MeV/m is produced at 200 MW input power. The linac accelerates 20 bunches of electrons with bunch separation of 2.8 ns. The accelerating structures, beam monitors and Q-magnets are aligned within ±50 μm by active alignment system. The energy spectrum of multi-bunch is compressed to ±0.16% by the energy compensation system. (author)

  11. Quantitative phase retrieval with picosecond X-ray pulses from the ATF Inverse Compton Scattering source

    International Nuclear Information System (INIS)

    Quantitative phase retrieval is experimentally demonstrated using the Inverse Compton Scattering X-ray source available at the Accelerator Test Facility (ATF) in the Brookhaven National Laboratory. Phase-contrast images are collected using in-line geometry, with a single X-ray pulse of approximate duration of one picosecond. The projected thickness of homogeneous samples of various polymers is recovered quantitatively from the time-averaged intensity of transmitted X-rays. The data are in good agreement with the expectations showing that ATF Inverse Compton Scattering source is suitable for performing phase-sensitive quantitative X-ray imaging on the picosecond scale. The method shows promise for quantitative imaging of fast dynamic phenomena.

  12. An overview on research developments of toroidal continuously variable transmissions

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    As environmental protection agencies enact new regulations for automotive fuel economy and emission, the toroidal continuously variable transmissions (CVTs) keep on contribute to the advent of system technologies for better fuel consumption of automobiles with internal combustion engines (ICE). Toroidal CVTs use infinitely adjustable drive ratios instead of stepped gears to achieve optimal performance. Toroidal CVTs are one of the earliest patents to the automotive world but their torque capacities and reliability have limitations in the past. New developments and implementations in the control strategies, and several key technologies have led to development of more robust toroidal CVTs, which enables more extensive automotive application of toroidal CTVs. This paper concerns with the current development, upcoming and progress set in the context of the past development and the traditional problems associated with toroidal CVTs.

  13. Macroscopic electromagnetic response of metamaterials with toroidal resonances

    CERN Document Server

    Savinov, V; Zheludev, N I

    2013-01-01

    Toroidal dipole, first described by Ia. B. Zeldovich [Sov. Phys. JETP 33, 1184 (1957)], is a distinct electromagnetic excitation that differs both from the electric and the magnetic dipoles. It has a number of intriguing properties: static toroidal nuclear dipole is responsible for parity violation in atomic spectra; interactions between static toroidal dipole and oscillating magnetic dipole are claimed to violate Newton's Third Law while non-stationary charge-current configurations involving toroidal multipoles have been predicted to produce vector potential in the absence of electromagnetic fields. Existence of the toroidal response in metamaterials was recently demonstrated and is now a growing field of research. However, no direct analytical link has yet been established between the transmission and reflection of macroscopic electromagnetic media and toroidal dipole excitations. To address this essential gap in electromagnetic theory we have developed an analytical approach linking microscopic and macrosc...

  14. Regression/eradication of gliomas in mice by a systemically-deliverable ATF5 dominant-negative peptide.

    Science.gov (United States)

    Cates, Charles C; Arias, Angelo D; Nakayama Wong, Lynn S; Lamé, Michael W; Sidorov, Maxim; Cayanan, Geraldine; Rowland, Douglas J; Fung, Jennifer; Karpel-Massler, Georg; Siegelin, Markus D; Greene, Lloyd A; Angelastro, James M

    2016-03-15

    Malignant gliomas have poor prognosis and urgently require new therapies. Activating Transcription Factor 5 (ATF5) is highly expressed in gliomas, and interference with its expression/function precipitates targeted glioma cell apoptosis in vitro and in vivo. We designed a novel deliverable truncated-dominant-negative (d/n) form of ATF5 fused to a cell-penetrating domain (Pen-d/n-ATF5-RP) that can be intraperitoneally/subcutaneously administered to mice harboring malignant gliomas generated; (1) by PDGF-B/sh-p53 retroviral transformation of endogenous neural progenitor cells; and (2) by human U87-MG xenografts. In vitro Pen-d/n-ATF5-RP entered into glioma cells and triggered massive apoptosis. In vivo, subcutaneously-administered Pen-d/n-ATF5-RP passed the blood brain barrier, entered normal brain and tumor cells, and then caused rapid selective tumor cell death. MRI verified elimination of retrovirus-induced gliomas within 8-21 days. Histopathology revealed growth-suppression of intracerebral human U87-MG cells xenografts. For endogenous PDGF-B gliomas, there was no recurrence or mortality at 6-12 months versus 66% mortality in controls at 6 months. Necropsy and liver-kidney blood enzyme analysis revealed no adverse effects on brain or other tissues. Our findings thus identify Pen-d/n-ATF5-RP as a potential therapy for malignant gliomas. PMID:26863637

  15. ATF4 mediation of NF1 functions in osteoblast reveals a nutritional basis for congenital skeletal dysplasiae.

    Science.gov (United States)

    Elefteriou, Florent; Benson, M Douglas; Sowa, Hideaki; Starbuck, Michael; Liu, Xiuyun; Ron, David; Parada, Luis F; Karsenty, Gerard

    2006-12-01

    The transcription factor ATF4 enhances bone formation by favoring amino acid import and collagen synthesis in osteoblasts, a function requiring its phosphorylation by RSK2, the kinase inactivated in Coffin-Lowry Syndrome. Here, we show that in contrast, RSK2 activity, ATF4-dependent collagen synthesis, and bone formation are increased in mice lacking neurofibromin in osteoblasts (Nf1(ob)(-/-) mice). Independently of RSK2, ATF4 phosphorylation by PKA is enhanced in Nf1(ob)(-/-) mice, thereby increasing Rankl expression, osteoclast differentiation, and bone resorption. In agreement with ATF4 function in amino acid transport, a low-protein diet decreased bone protein synthesis and normalized bone formation and bone mass in Nf1(ob)(-/-) mice without affecting other organ weight, while a high-protein diet overcame Atf4(-/-) and Rsk2(-/-) mice developmental defects, perinatal lethality, and low bone mass. By showing that ATF4-dependent skeletal dysplasiae are treatable by dietary manipulations, this study reveals a molecular connection between nutrition and skeletal development. PMID:17141628

  16. Signaling dynamics of palmitate-induced ER stress responses mediated by ATF4 in HepG2 cells

    Directory of Open Access Journals (Sweden)

    Cho Hyunju

    2013-01-01

    Full Text Available Abstract Background Palmitic acid, the most common saturated free fatty acid, has been implicated in ER (endoplasmic reticulum stress-mediated apoptosis. This lipoapotosis is dependent, in part, on the upregulation of the activating transcription factor-4 (ATF4. To better understand the mechanisms by which palmitate upregulates the expression level of ATF4, we integrated literature information on palmitate-induced ER stress signaling into a discrete dynamic model. The model provides an in silico framework that enables simulations and predictions. The model predictions were confirmed through further experiments in human hepatocellular carcinoma (HepG2 cells and the results were used to update the model and our current understanding of the signaling induced by palmitate. Results The three key things from the in silico simulation and experimental results are: 1 palmitate induces different signaling pathways (PKR (double-stranded RNA-activated protein kinase, PERK (PKR-like ER kinase, PKA (cyclic AMP (cAMP-dependent protein kinase A in a time dependent-manner, 2 both ATF4 and CREB1 (cAMP-responsive element-binding protein 1 interact with the Atf4 promoter to contribute to a prolonged accumulation of ATF4, and 3 CREB1 is involved in ER-stress induced apoptosis upon palmitate treatment, by regulating ATF4 expression and possibly Ca2+ dependent-CaM (calmodulin signaling pathway. Conclusion The in silico model helped to delineate the essential signaling pathways in palmitate-mediated apoptosis.

  17. Helical coil alignment in the advanced toroidal facility

    International Nuclear Information System (INIS)

    This paper presents a brief overview of the helical coil design concept, detailed descriptions of the method for installation and alignment, and discussions of segment installation and alignment equipment. Alignment is accomplished by optical methods using electronic theodolites connected to a microcomputer to form a coordinate measurement system. The coordinate measurement system is described in detail, along with target selection and fixturing for manipulation of the helical coil segments during installation. In addition, software is described including vendor-supplied software used in the coordinate measurement system and in-house-developed software used to calibrate segment and positioning fixture motion. 2 refs., 8 figs

  18. Role of activated transcription factor 4 (ATF4) in learning and memory

    OpenAIRE

    Pasini

    2011-01-01

    The aim of this study is to understand the role of Activated Transcription Factor 4 (ATF4) in the processes of learning and memory. The topic of learning and memory has always aroused great interest from time immemorial and although a lot of researches have been focused on this subject for a long time, many mechanisms have not yet been fully understood. Identifying the players and the mechanisms involved in learning and memory is of utmost importance because deficits in these cognitive fu...

  19. Detection of Ground Motion effects on the beam trajectory at ATF2

    CERN Document Server

    Renier, Y; Tomas, R; Schulte, D

    2012-01-01

    The ATF2 experiment is currently demonstrating the feasibility of the beam delivery system for the future linear collider. The orbit feedback is very critical to obtain the nanometer vertical beam size at the interaction point and in the case of CLIC, ground motion effects on the beam must be corrected. In this respect, as a proof of principle of a ground motion feed forward, the ground motion effects on the beam trajectory are extracted from the beam position monitor readings.

  20. Farnesol activates the intrinsic pathway of apoptosis and the ATF4-ATF3-CHOP cascade of ER stress in human T lymphoblastic leukemia Molt4 cells.

    Science.gov (United States)

    Joo, Joung Hyuck; Ueda, Eiichiro; Bortner, Carl D; Yang, Xiao-Ping; Liao, Grace; Jetten, Anton M

    2015-10-01

    In this study, we demonstrate that treatment of T lymphoblastic leukemic Molt4 cells with farnesol activates the apoptosome via the intrinsic pathway of apoptosis. This induction was associated with changes in the level of intracellular potassium and calcium, the dissipation of the mitochondrial and plasma membrane potential, release of cytochrome c, activation of several caspases, and PARP cleavage. The induction of apoptosis by farnesol was inhibited by the addition of the pan-caspase inhibitor Z-VAD-fmk and by the exogenous expression of the anti-apoptotic protein Bcl2. Analysis of the gene expression profiles by microarray analysis revealed that farnesol increased the expression of several genes related to the unfolded protein response (UPR), including CHOP and CHAC1. This induction was associated with the activation of the PERK-eIF2α-ATF3/4 cascade, but not the XBP-1 branch of the UPR. Although farnesol induced activation of the ERK1/2, p38, and JNK pathways, inhibition of these MAPKs had little effect on farnesol-induced apoptosis or the induction of UPR-related genes. Our data indicate that the induction of apoptosis in leukemic cells by farnesol is mediated through a pathway that involves activation of the apoptosome via the intrinsic pathway and induction of the PERK-eIF2α-ATF3/4 cascade in a manner that is independent of the farnesol-induced activation of MAPKs. PMID:26275811

  1. Macroscopic electromagnetic response of metamaterials with toroidal resonances

    OpenAIRE

    Savinov, V.; Fedotov, V. A.; Zheludev, N. I.

    2013-01-01

    Toroidal dipole, first described by Ia. B. Zeldovich [Sov. Phys. JETP 33, 1184 (1957)], is a distinct electromagnetic excitation that differs both from the electric and the magnetic dipoles. It has a number of intriguing properties: static toroidal nuclear dipole is responsible for parity violation in atomic spectra; interactions between static toroidal dipole and oscillating magnetic dipole are claimed to violate Newton's Third Law while non-stationary charge-current configurations involving...

  2. Toroidal plasma enhanced CVD of diamond films

    International Nuclear Information System (INIS)

    An inductively coupled toroidal plasma source is used as an alternative to microwave plasmas for chemical vapor deposition of diamond films. The source, operating at a frequency of 400 kHz, synthesizes diamond films from a mixture of argon, methane, and hydrogen. The toroidal design has been adapted to create a highly efficient environment for diamond film deposition: high gas temperature and a short distance from the sample to the plasma core. Using a toroidal plasma geometry operating in the medium frequency band allows for efficient (≈90%) coupling of AC line power to the plasma and a scalable path to high-power and large-area operation. In test runs, the source generates a high flux of atomic hydrogen over a large area, which is favorable for diamond film growth. Using a deposition temperature of 900–1050 °C and a source to sample distance of 0.1–2.0 cm, diamond films are deposited onto silicon substrates. The results showed that the deposition rate of the diamond films could be controlled using the sample temperature and source to sample spacing. The results also show the films exhibit good-quality polycrystalline diamond as verified by Raman spectroscopy, x-ray diffraction, and scanning electron microscopy. The scanning electron microscopy and x-ray diffraction results show that the samples exhibit diamond (111) and diamond (022) crystallites. The Raman results show that the sp3 peak has a narrow spectral width (FWHM 12 ± 0.5 cm−1) and that negligible amounts of the sp2 band are present, indicating good-quality diamond films

  3. Edge ambipolar potential in toroidal fusion plasmas

    Energy Technology Data Exchange (ETDEWEB)

    Spizzo, G., E-mail: gianluca.spizzo@igi.cnr.it; Vianello, N.; Agostini, M.; Puiatti, M. E.; Scarin, P.; Spolaore, M.; Terranova, D. [Consorzio RFX, Euratom-ENEA Association and Istituto Gas Ionizzati del CNR, Corso Stati Uniti, 4 35127 Padova (Italy); White, R. B. [Plasma Physics Laboratory, Princeton University, P.O. Box 451, Princeton, New Jersey 08543 (United States); Abdullaev, S. S.; Schmitz, O. [Institut für Energieforschung-Plasmaphysik, Association EURATOM-FZJ, Jülich (Germany); Cavazzana, R. [Consorzio RFX, Euratom-ENEA Association, Corso Stati Uniti, 4 35127 Padova (Italy); Ciaccio, G. [Dipartimento di Fisica, Università degli studi di Padova, Padova (Italy)

    2014-05-15

    A series of issues with toroidally confined fusion plasmas are related to the generation of 3D flow patterns by means of edge magnetic islands, embedded in a chaotic field and interacting with the wall. These issues include the Greenwald limit in Tokamaks and reversed-field pinches, the collisionality window for ELM mitigation with the resonant magnetic perturbations (RMPs) in Tokamaks, and edge islands interacting with the bootstrap current in stellarators. Measurements of the 2D map of the edge electric field E{sup r}(r=a,θ,ϕ) in the RFX reversed-field pinch show that E{sup r} has the same helicity of the magnetic islands generated by a m/n perturbation: in fact, defining the helical angle u=mθ−nϕ+ωt, maps show a sinusoidal dependence as a function of u, E{sup r}=E{sup ~r}sin u. The associated E × B flow displays a huge convective cell with v(a)≠0 which, in RFX and near the Greenwald limit, determines a stagnation point for density and a reversal of the sign of E{sup r}. From a theoretical point of view, the question is how a perturbed toroidal flux of symmetry m/n gives rise to an ambipolar potential Φ=Φ{sup ~}sin u. On the basis of a model developed with the guiding center code ORBIT and applied to RFX and the TEXTOR tokamak, we will show that the presence of an m/n perturbation in any kind of device breaks the toroidal symmetry with a drift proportional to the gyroradius ρ, thus larger for ions (ρ{sub i} ≫ ρ{sub e}). Immediately, an ambipolar potential arises to balance the drifts, with the same symmetry as the original perturbation.

  4. Electrical disruption in toroidal plasma of hydrogen

    International Nuclear Information System (INIS)

    The initial phase of ionization of a toroidal plasma produced in hydrogen was investigated using zero-dimensional model. The model describes the temporal evolution of plasma by spatial medium of particle density and temperature, on whole plasma volume. The energy and particle (electrons and ions) balance equations are considered. The electron loss is due to ambipolar diffusion in the presence of magnetic field. The electron energy loss involves ionization, Coulomb interaction and diffusion. The ohmic heating converter gives the initial voltage necessary to disruption. (M.C.K.)

  5. Plasma current resonance in asymmetric toroidal systems

    Energy Technology Data Exchange (ETDEWEB)

    Hazeltine, R. D. [Institute for Fusion Studies, University of Texas at Austin, Austin, Texas 78712 (United States); Catto, Peter J. [Plasma Science and Fusion Center, Massachusetts Institute of Technology, 167 Albany Street, Cambridge, Massachusetts 02139 (United States)

    2015-09-15

    The well-known singularity in the magnetic differential equation for plasma current in an asymmetric toroidal confinement system is resolved by including in the pressure tensor corrections stemming from finite Larmor radius. The result provides an estimate of the amplitude of spikes in the parallel current that occur on rational magnetic surfaces. Resolution of the singularity is shown to depend on both the ambipolarity condition—the requirement of zero surface-averaged radial current—and the form of the magnetic differential equation near the rational surface.

  6. General Atomic's superconducting toroidal field coil concept

    International Nuclear Information System (INIS)

    General Atomic's concept for a superconducting toroidal field coil is presented. The concept is generic for large tokamak devices, while a specific design is indicated for a 3.8 meter (major radius) ignition/burn machine. The concept utilizes bath cooled NbTi conductor to generate a peak field of 10 tesla at 4.2 K. The design is simple and straightforward, requires a minimum of developmental effort, and draws extensively upon the perspective of past experience in the design and construction of large superconducting magnets for high energy physics. Thus, the primary emphasis is upon economy, reliability, and expeditious construction scheduling. (author)

  7. Proposal to produce large compact toroids

    International Nuclear Information System (INIS)

    Relatively large, hot compact toroids might be produced in the annular space between two concentric one-turn coils. With currents in the two coils flowing in the same direction, the magnetic fields on each side of the plasma are in opposite directions. As the fields are raised, the plasma ring is heated and compressed radially towards the center of the annular space. By the addition of two sets of auxiliary coils, the plasma ring can be ejected out one end of the two-coil system into a long axial magnetic field

  8. Electric disruption in a hydrogen toroidal plasma

    International Nuclear Information System (INIS)

    By using a zero-dimensional model the ionizing initial phase of a toroidal plasma produced in hydrogen was investigated. The model consists on describing the plasma time evolution through the density and particle temperature space averaged on the plasma volume. The involved equations are energy and particles balance equations (electrons and ions). The electron loss is due to ambipolar diffusion in the presence of magnetic field. The electron energy loss is due to ionizing, processes of Coulomb interaction and diffusion. The ohmic heating transformer gives a initial voltage necessary to the breaking

  9. Toroidal membrane vesicles in spherical confinement

    CERN Document Server

    Bouzar, Lila; Müller, Martin Michael

    2015-01-01

    We investigate the morphology of a toroidal fluid membrane vesicle confined inside a spherical container. The equilibrium shapes are assembled in a geometrical phase diagram as a function of scaled area and reduced volume of the membrane. For small area the vesicle can adopt its free form. When increasing the area, the membrane cannot avoid contact and touches the confining sphere along a circular contact line, which extends to a zone of contact for higher area. The elastic energies of the equilibrium shapes are compared to those of their confined counterparts of spherical topology to predict under which conditions a topology change is favored energetically.

  10. Toroidal membrane vesicles in spherical confinement.

    Science.gov (United States)

    Bouzar, Lila; Menas, Ferhat; Müller, Martin Michael

    2015-09-01

    We investigate the morphology of a toroidal fluid membrane vesicle confined inside a spherical container. The equilibrium shapes are assembled in a geometrical phase diagram as a function of scaled area and reduced volume of the membrane. For small area the vesicle can adopt its free form. When increasing the area, the membrane cannot avoid contact and touches the confining sphere along a circular contact line, which extends to a zone of contact for higher area. The elastic energies of the equilibrium shapes are compared to those of their confined counterparts of spherical topology to predict under which conditions a topology change is favored energetically. PMID:26465512

  11. 3D Printing the ATLAS' barrel toroid

    CERN Document Server

    Goncalves, Tiago Barreiro

    2016-01-01

    The present report summarizes my work as part of the Summer Student Programme 2016 in the CERN IR-ECO-TSP department (International Relations – Education, Communication & Outreach – Teacher and Student Programmes). Particularly, I worked closely with the S’Cool LAB team on a science education project. This project included the 3D designing, 3D printing, and assembling of a model of the ATLAS’ barrel toroid. A detailed description of the project' development is presented and a short manual on how to use 3D printing software and hardware is attached.

  12. Pulsar Wind Nebulae with Thick Toroidal Structure

    OpenAIRE

    Chevalier, Roger A.; Reynolds, Stephen P.

    2011-01-01

    We investigate a class of pulsar wind nebulae that show synchrotron emission from a thick toroidal structure. The best studied such object is the small radio and X-ray nebula around the Vela pulsar, which can be interpreted as the result of interaction of a mildly supersonic inward flow with the recent pulsar wind. Such a flow near the center of a supernova remnant can be produced in a transient phase when the reverse shock reaches the center of the remnant. Other nebulae with a thick toroida...

  13. Burn control resulting from toroidal field ripple

    International Nuclear Information System (INIS)

    The enhanced transport due to toroidal magnetic field ripple is proposed as a means of averting thermal runaway in a tokamak reactor in the post-ignition stage. A theoretical analysis applied to a typical reactor design reveals that peak-to-average edge ripple of the order of 2% is sufficient to terminate the thermal excursion at reasonable values of β without significantly increasing the difficulty of reaching ignition. These analytic predictions, which are shown to agree well with radial transport code results, suggest that a properly specified ripple is one way of achieving a controlled burn in tokamak reactors. (author)

  14. Continuum damping of ideal toroidal Alfven eigenmodes

    International Nuclear Information System (INIS)

    A perturbation theory based on the two dimensional (2D) ballooning transform is systematically developed for ideal toroidal Alfven eigenmodes (TAEs). A formula, similar to the Fermi golden rule for decaying systems in quantum mechanics, is derived for the continuum damping rate of the TAE; the decay (damping) rate is expressed explicitly in terms of the coupling of the TAE to the continuum spectrum. Numerical results are compared with previous calculations. It is found that in some narrow intervals of the parameter mε the damping rate varies very rapidly. These regions correspond precisely to the root missing intervals of the numerical solution by Rosenbluth et al

  15. 3D blob dynamics in toroidal geometry

    DEFF Research Database (Denmark)

    Nielsen, Anders Henry; Reiser, Dirk

    DIESEL code is an extension of the ESEL code [1]. It solves a simple interchange model in full 3D tokamak geometry, where the toroidal direction is divided into a number of drift planes. On each drift plane the equations are solved in a domain corresponding to the full 2D cross section of the tokamak and...... communicate parallel with the nearest drift planes using parameterized velocities, the ion sound speed, Cs for the density equation and the Alfvén speed VA for the vorticity equation. Results show that a decrease of Alfvénic interaction of electric potential and current density leads to the expected radial...

  16. Systems analysis of ATF3 in stress response and cancer reveals opposing effects on pro-apoptotic genes in p53 pathway.

    Directory of Open Access Journals (Sweden)

    Yujiro Tanaka

    Full Text Available Stress-inducible transcription factors play a pivotal role in cellular adaptation to environment to maintain homeostasis and integrity of the genome. Activating transcription factor 3 (ATF3 is induced by a variety of stress and inflammatory conditions and is over-expressed in many kinds of cancer cells. However, molecular mechanisms underlying pleiotropic functions of ATF3 have remained elusive. Here we employed systems analysis to identify genome-wide targets of ATF3 that is either induced by an alkylating agent methyl methanesulfonate (MMS or over-expressed in a prostate tumour cell line LNCaP. We show that stress-induced and cancer-associated ATF3 is recruited to 5,984 and 1,423 targets, respectively, in the human genome, 89% of which are common. Notably, ATF3 targets are highly enriched for not only ATF/CRE motifs but also binding sites of several other stress-inducible transcription factors indicating an extensive network of stress response factors in transcriptional regulation of target genes. Further analysis of effects of ATF3 knockdown on these targets revealed that stress-induced ATF3 regulates genes in metabolic pathways, cell cycle, apoptosis, cell adhesion, and signalling including insulin, p53, Wnt, and VEGF pathways. Cancer-associated ATF3 is involved in regulation of distinct sets of genes in processes such as calcium signalling, Wnt, p53 and diabetes pathways. Notably, stress-induced ATF3 binds to 40% of p53 targets and activates pro-apoptotic genes such as TNFRSF10B/DR5 and BBC3/PUMA. Cancer-associated ATF3, by contrast, represses these pro-apoptotic genes in addition to CDKN1A/p21. Taken together, our data reveal an extensive network of stress-inducible transcription factors and demonstrate that ATF3 has opposing, cell context-dependent effects on p53 target genes in DNA damage response and cancer development.

  17. Aspects of Tokamak toroidal magnet protection

    International Nuclear Information System (INIS)

    Simple but conservative geometric models are used to estimate the potential for damage to a Tokamak reactor inner wall and blanket due to a toroidal magnet field collapse. The ofly potential hazard found to exist is due to the MHD pressure rise in a lithium blanket. A survey is made of proposed protection methods for superconducting torgidal magnets. It is found that the two general classificatigls of protectign methods are thermal and electrical. Computer programs were developed which aldow the toroidal magnet set to be modeled as a set of circular filaments. A simple thermal model of the conductor was used which allows heat transfer to the magnet structure and which includes the effect of temperature dependent properties. To be effective in large magnets an electrical protection system should remove at least 50% of the stored energy in the protection circuit assuming that all of the superconductor in the circuit quenches when the circuit is activated. A protection system design procedure based on this criterion was developed

  18. Microwave produced plasma in a Toroidal Device

    Science.gov (United States)

    Singh, A. K.; Edwards, W. F.; Held, E. D.

    2010-11-01

    A currentless toroidal plasma device exhibits a large range of interesting basic plasma physics phenomena. Such a device is not in equilibrium in a strict magneto hydrodynamic sense. There are many sources of free energy in the form of gradients in plasma density, temperature, the background magnetic field and the curvature of the magnetic field. These free energy sources excite waves and instabilities which have been the focus of studies in several devices in last two decades. A full understanding of these simple plasmas is far from complete. At Utah State University we have recently designed and installed a microwave plasma generation system on a small tokamak borrowed from the University of Saskatchewan, Saskatoon, Canada. Microwaves are generated at 2.45 GHz in a pulsed dc mode using a magnetron from a commercial kitchen microwave oven. The device is equipped with horizontal and vertical magnetic fields and a transformer to impose a toroidal electric field for current drive. Plasmas can be obtained over a wide range of pressure with and without magnetic fields. We present some preliminary measurements of plasma density and potential profiles. Measurements of plasma temperature at different operating conditions are also presented.

  19. Propulsion using the electron spiral toroid

    International Nuclear Information System (INIS)

    A new propulsion method is proposed which could potentially reduce propellant needed for space travel by three orders of magnitude. It uses the newly patented electron spiral toroid (EST), which stores energy as magnetic field energy. The EST is a hollow toroid of electrons, all spiraling in parallel paths in a thin outer shell. The electrons satisfy the coupling condition, forming an electron matrix. Stability is assured as long as the coupling condition is satisfied. The EST is held in place with a small external electric field; without an external magnetic field. The EST system is contained in a vacuum chamber. The EST can be thought of as an energetic entity, with electrons at 10,000 electron volts. Propulsion would not use combustion, but would heat propellant through elastic collisions with the EST surface and eject them for thrust. Chemical rocket combustion heats propellant to 4000 deg. C; an EST will potentially heat the propellant 29,000 times as much, reducing propellant needs accordingly. The thrust can be turned ON and OFF. The EST can be recharged as needed

  20. Computational simulation of compact toroidal plasma formation

    International Nuclear Information System (INIS)

    The following computational efforts are part of the MARAUDER (magnetically accelerated rings to achieve ultra-high directed energy and radiation) research program at the High Energy Plasma Division of the Weapons Laboratory. The program is investigating plasma toroids with magnetic fields similar to those of tokamaks. These fields confine the plasma between a pair of cylindrical conductors. The objective of the research is to first form such toroids and then compress and accelerate them. A 500 kJ capacitor bank will be used for the formation, and the 9 MJ Shiva Star will be used for acceleration. The first set of experiments and current computational work consider only the formation process. The computer program used for these simulations is MACH2. It is a two-dimensional MHD code and was originally developed by Mission Research Corporation under a Weapons Laboratory contract to support z-pinch research. MACH2 is an Arbitrary Lagrangian-Eulerian code with an adaptive mesh capability. Its diffusion routines use a multigrid technique to accelerate convergence. Recently, a second-order advection scheme has been added

  1. Intranasal administration of aTf protects and repairs the neonatal white matter after a cerebral hypoxic-ischemic event.

    Science.gov (United States)

    Guardia Clausi, Mariano; Paez, Pablo M; Campagnoni, Anthony T; Pasquini, Laura A; Pasquini, Juana M

    2012-10-01

    Our previous studies showed that the intracerebral injection of apotransferrin (aTf) attenuates white matter damage and accelerates the remyelination process in a neonatal rat model of cerebral hypoxia-ischemia (HI) injury. However, the intracerebral injection of aTf might not be practical for clinical treatments. Therefore, the development of less invasive techniques capable of delivering aTf to the central nervous system would clearly aid in its effective clinical use. In this work, we have determined whether intranasal (iN) administration of human aTf provides neuroprotection to the neonatal mouse brain following a cerebral hypoxic-ischemic event. Apotransferrin was infused into the naris of neonatal mice and the HI insult was induced by right common carotid artery ligation followed by exposure to low oxygen concentration. Our results showed that aTf was successfully delivered into the neonatal HI brain and detected in the olfactory bulb, forebrain and posterior brain 30 min after inhalation. This treatment successfully reduced white matter damage, neuronal loss and astrogliosis in different brain regions and enhanced the proliferation and survival of oligodendroglial progenitor cells (OPCs) in the subventricular zone and corpus callosum (CC). Additionally, using an in vitro hypoxic model, we demonstrated that aTf prevents oligodendrocyte progenitor cell death by promoting their differentiation. In summary, these data suggest that iN administration of aTf has the potential to be used for clinical treatment to protect myelin and to induce remyelination in demyelinating hypoxic-ischemic events in the neonatal brain. PMID:22736466

  2. Binding of the transcription factor Atf1 to promoters serves as a barrier to phase nucleosome arrays and avoid cryptic transcription

    Science.gov (United States)

    García, Patricia; Paulo, Esther; Gao, Jun; Wahls, Wayne P.; Ayté, José; Lowy, Ernesto; Hidalgo, Elena

    2014-01-01

    Schizosaccharomyces pombe displays a large transcriptional response common to several stress conditions, regulated primarily by the transcription factor Atf1. Atf1-dependent promoters contain especially broad nucleosome depleted regions (NDRs) prior to stress imposition. We show here that basal binding of Atf1 to these promoters competes with histones to create wider NDRs at stress genes. Moreover, deletion of atf1 results in nucleosome disorganization specifically at stress coding regions and derepresses antisense transcription. Our data indicate that the transcription factor binding to promoters acts as an effective barrier to fix the +1 nucleosome and phase downstream nucleosome arrays to prevent cryptic transcription. PMID:25122751

  3. Performance of a Folded-Strip Toroidally Wound Induction Machine

    DEFF Research Database (Denmark)

    Jensen, Bogi Bech; Jack, Alan G.; Atkinson, Glynn J.; Mecrow, Barrie C.

    2011-01-01

    This paper presents the measured experimental results from a four-pole toroidally wound induction machine, where the stator is constructed as a pre-wound foldable strip. It shows that if the machine is axially restricted in length, the toroidally wound induction machine can have substantially sho...

  4. Effect of toroidal magnetic field and plasma rotation on compact toriequilibria

    International Nuclear Information System (INIS)

    The effect of toroidal magnetic field and plasma rotation on compact tori equilibrium configurations is studied. It is found that the equilibrium configurations exist in any toroidal fields. The field dependences of toroidal parameters are analyzed. The effect of opening of the toroidal separatrix and the influence of the toroidal magnetic field, toroidal rotation, the pressure profile type behind the separatrix on it is studied as well. 13 refs.; 11 figs.; 2 tabs

  5. Plasmonic Toroidal Dipolar Response under Radially Polarized Excitation

    Science.gov (United States)

    Bao, Yanjun; Zhu, Xing; Fang, Zheyu

    2015-01-01

    Plasmonic toroidal resonance has attracted growing interests because of its low loss electromagnetic properties and potential high sensitive nanophotonic applications. However, the realization in a metamaterial requires three-dimensional complicated structural design so far. In this paper, we design a simple metal-dielectric-metal (MIM) sandwich nanostructure, which exhibits a strong toroidal dipolar resonance under radially polarized excitation. The toroidal dipole moment as the dominant contribution for the scattering is demonstrated by the mirror-image method and further analyzed by Lagrangian hybridization model. The proposed toroidal configuration also shows a highly tolerant for misalignment between the structure center and the incident light focus. Our study proves the way for the toroidal plasmonic application with the cylindrical vector beams. PMID:26114966

  6. Toroidal gyrofluid equations for simulations of tokamak turbulence

    International Nuclear Information System (INIS)

    A set of nonlinear gyrofluid equations for simulations of tokamak turbulence are derived by taking moments of the nonlinear toroidal gyrokinetic equation. The moment hierarchy is closed with approximations that model the kinetic effects of parallel Landau damping, toroidal drift resonances, and finite Larmor radius effects. These equations generalize the work of Dorland and Hammett [Phys. Fluids B 5, 812 (1993)] to toroidal geometry by including essential toroidal effects. The closures for phase mixing from toroidal rB and curvature drifts take the basic form presented in Waltz, et al. [Phys. Fluids B 4, 3138 (1992)], but here a more rigorous procedure is used, including an extension to higher moments, which provides significantly improved accuracy. In addition, trapped ion effects and collisions are incorporated. This reduced set of nonlinear equations accurately models most of the physics considered important for ion dynamics in core tokamak turbulence and is simple enough to be used in high resolution direct numerical simulations

  7. Quench propagation and protection analysis of the ATLAS Toroids

    CERN Document Server

    Dudarev, A; ten Kate, H H J; Baynham, D Elwyn; Courthold, M J D; Lesmond, C

    2000-01-01

    The ATLAS superconducting magnet system consists of the Barrel Toroid, two End Cap Toroids and the Central Solenoid. However, the Toroids of eight coils each are magnetically separate systems to the Central Solenoid. The Toroids are electrically connected in series and energized by a single power supply. The quench protection system is based on the use of relatively small external dump resistances in combination with quench-heaters activated after a quench event detection to initiate the internal dump of stored energy in all the coils. A rather strong quench-back effect due to eddy-currents in the coil casings at the transport current decay is beneficial for the quench protection efficiency in the event of heater failures. The quench behaviour of the ATLAS Toroids was computer simulated for normal operation of the quench protection system and its complete non-operation (failure) mode. (3 refs).

  8. Perturbing macroscopic magnetohydrodynamic stability for toroidal plasmas

    Science.gov (United States)

    Comer, Kathryn J.

    We have introduced a new perturbative technique to rapidly explore the dependence of long wavelength ideal magnetohydrodynamic (MHD) instabilities on equilibrium profiles, shaping properties, and wall parameters. Traditionally, these relations are studied with numerical parameter scans using computationally intensive stability codes. Our perturbative technique first finds the equilibrium and stability using traditional methods. Subsequent small changes in the original equilibrium parameters change the stability. We quickly find the new stability with an expansion of the energy principle, rather than with another run of the stability codes. We first semi-analytically apply the technique to the screw pinch after eliminating compressional Alfven wave effects. The screw pinch results validate the approach, but also indicate that allowable perturbations to equilibria with certain features may be restricted. Next, we extend the approach to toroidal geometry using experimental equilibria and a simple constructed equilibrium, with the ideal MHD stability code GATO. Stability properties are successfully predicted from perturbed toroidal equilibria when only the vacuum beyond the plasma is perturbed (through wall parameter variations), rather than the plasma itself. Small plasma equilibrium perturbations to both experimental and simple equilibria result in very large errors to the predicted stability, and valid results are found only over a narrow range of most perturbations. Despite the large errors produced when changing plasma parameters, the wall perturbations revealed two useful applications of this technique. Because the calculations are non-iterative matrix multiplications, the convergence issues that can disrupt a full MHD stability code are absent. Marginal stability, therefore, is much easier to find with the perturbative technique. Also, the perturbed results can be input as the initial guess for the eigenvalue for a full stability code, and improve subsequent

  9. Toroidicity and shape dependence of peeling mode growth rates in axisymmetric toroidal plasmas

    International Nuclear Information System (INIS)

    The growth rate of the peeling mode instability with large toroidal mode number is calculated for general axisymmetric toroidal plasmas, including tokamaks and the spherical torus (ST) equilibia by using formalism presented by Connor et al. Analytic equilibia with non-zero edge current density and quasi-uniform current profiles are assumed. It is found that in sharp D-shape tokamak plasma, the derivative of the safety factor with respect to the poloidal flux becomes very large, making the perturbed poloidal motion very large, in turn making a significant reduction of the growth rate of the peeling mode, similar to the X-point effect in diverted plasma. The large aspect ratio effect is also studied, which reduces the growth rate further. (physics of gases, plasmas, and electric discharges)

  10. Phosphorylation-Independent Regulation of Atf1-Promoted Meiotic Recombination by Stress-Activated, p38 Kinase Spc1 of Fission Yeast

    Science.gov (United States)

    Gao, Jun; Davidson, Mari K.; Wahls, Wayne P.

    2009-01-01

    Background Stress-activated protein kinases regulate multiple cellular responses to a wide variety of intracellular and extracellular conditions. The conserved, multifunctional, ATF/CREB protein Atf1 (Mts1, Gad7) of fission yeast binds to CRE-like (M26) DNA sites. Atf1 is phosphorylated by the conserved, p38-family kinase Spc1 (Sty1, Phh1) and is required for many Spc1-dependent stress responses, efficient sexual differentiation, and activation of Rec12 (Spo11)-dependent meiotic recombination hotspots like ade6-M26. Methodology/Principal Findings We sought to define mechanisms by which Spc1 regulates Atf1 function at the ade6-M26 hotspot. The Spc1 kinase was essential for hotspot activity, but dispensable for basal recombination. Unexpectedly, a protein lacking all eleven MAPK phospho-acceptor sites and detectable phosphorylation (Atf1-11M) was fully proficient for hotspot recombination. Furthermore, tethering of Atf1 to ade6 in the chromosome by a heterologous DNA binding domain bypassed the requirement for Spc1 in promoting recombination. Conclusions/Significance The Spc1 protein kinase regulates the pathway of Atf1-promoted recombination at or before the point where Atf1 binds to chromosomes, and this pathway regulation is independent of the phosphorylation status of Atf1. Since basal recombination is Spc1-independent, the principal function of the Spc1 kinase in meiotic recombination is to correctly position Atf1-promoted recombination at hotspots along chromosomes. We also propose new hypotheses on regulatory mechanisms for shared (e.g., DNA binding) and distinct (e.g., osmoregulatory vs. recombinogenic) activities of multifunctional, stress-activated protein Atf1. PMID:19436749

  11. Helicity of a toroidal vortex with swirl

    Science.gov (United States)

    Bannikova, E. Yu.; Kontorovich, V. M.; Poslavsky, S. A.

    2016-04-01

    Based on the solutions of the Bragg-Hawthorne equation, we discuss the helicity of a thin toroidal vortex in the presence of swirl, orbital motion along the torus directrix. The relation between the helicity and circulations along the small and large linked circumferences (the torus directrix and generatrix) is shown to depend on the azimuthal velocity distribution in the core of the swirling ring vortex. In the case of nonuniform swirl, this relation differs from the well-known Moffat relation, viz., twice the product of such circulations multiplied by the number of linkages. The results can find applications in investigating the vortices in planetary atmospheres and the motions in the vicinity of active galactic nuclei.

  12. Helicity of the toroidal vortex with swirl

    CERN Document Server

    Bannikova, Elena Yu; Poslavsky, Sergey A

    2016-01-01

    On the basis of solutions of the Bragg-Hawthorne equations we discuss the helicity of thin toroidal vortices with the swirl - the orbital motion along the torus diretrix. It is shown that relationship of the helicity with circulations along the small and large linked circles - directrix and generatrix of the torus - depends on distribution of the azimuthal velocity in the core of the swirling vortex ring. In the case of non-homogeneous swirl this relationship differs from the well-known Moffat relationship - the doubled product of such circulations multiplied by the number of links. The results can be applied to vortices in planetary atmospheres and to vortex movements in the vicinity of active galactic nuclei.

  13. Toroidal microinstability studies of high temperature tokamaks

    Energy Technology Data Exchange (ETDEWEB)

    Rewoldt, G.; Tang, W.M.

    1989-07-01

    Results from comprehensive kinetic microinstability calculations are presented showing the effects of toroidicity on the ion temperature gradient mode and its relationship to the trapped-electron mode in high-temperature tokamak plasmas. The corresponding particle and energy fluxes have also been computed. It is found that, although drift-type microinstabilities persist over a wide range of values of the ion temperature gradient parameter /eta//sub i/ /equivalent to/ (dlnT/sub i//dr)/(dlnn/sub i//dr), the characteristic features of the dominant mode are those of the /eta//sub i/-type instability when /eta//sub i/ > /eta//sub ic/ /approximately/1.2 to 1.4 and of the trapped-electron mode when /eta//sub i/ < /eta//sub ic/. 16 refs., 7 figs.

  14. The theory of toroidally confined plasmas

    CERN Document Server

    White, Roscoe B

    2014-01-01

    This graduate level textbook develops the theory of magnetically confined plasma, with the aim of bringing the reader to the level of current research in the field of thermonuclear fusion. It begins with the basic concepts of magnetic field description, plasma equilibria and stability, and goes on to derive the equations for guiding center particle motion in an equilibrium field. Topics include linear and nonlinear ideal and resistive modes and particle transport. It is of use to workers in the field of fusion both for its wide-ranging account of tokamak physics and as a kind of handbook or formulary. This edition has been extended in a number of ways. The material on mode-particle interactions has been reformulated and much new information added, including methodology for Monte Carlo implementation of mode destabilization. These results give explicit means of carrying out mode destabilization analysis, in particular for the dangerous fishbone mode. A new chapter on cyclotron motion in toroidal geometry has ...

  15. Petascale Parallelization of the Gyrokinetic Toroidal Code

    Energy Technology Data Exchange (ETDEWEB)

    Ethier, Stephane; Adams, Mark; Carter, Jonathan; Oliker, Leonid

    2010-05-01

    The Gyrokinetic Toroidal Code (GTC) is a global, three-dimensional particle-in-cell application developed to study microturbulence in tokamak fusion devices. The global capability of GTC is unique, allowing researchers to systematically analyze important dynamics such as turbulence spreading. In this work we examine a new radial domain decomposition approach to allow scalability onto the latest generation of petascale systems. Extensive performance evaluation is conducted on three high performance computing systems: the IBM BG/P, the Cray XT4, and an Intel Xeon Cluster. Overall results show that the radial decomposition approach dramatically increases scalability, while reducing the memory footprint - allowing for fusion device simulations at an unprecedented scale. After a decade where high-end computing (HEC) was dominated by the rapid pace of improvements to processor frequencies, the performance of next-generation supercomputers is increasingly differentiated by varying interconnect designs and levels of integration. Understanding the tradeoffs of these system designs is a key step towards making effective petascale computing a reality. In this work, we examine a new parallelization scheme for the Gyrokinetic Toroidal Code (GTC) [?] micro-turbulence fusion application. Extensive scalability results and analysis are presented on three HEC systems: the IBM BlueGene/P (BG/P) at Argonne National Laboratory, the Cray XT4 at Lawrence Berkeley National Laboratory, and an Intel Xeon cluster at Lawrence Livermore National Laboratory. Overall results indicate that the new radial decomposition approach successfully attains unprecedented scalability to 131,072 BG/P cores by overcoming the memory limitations of the previous approach. The new version is well suited to utilize emerging petascale resources to access new regimes of physical phenomena.

  16. The Role of the PERK/eIF2α/ATF4/CHOP Signaling Pathway in Tumor Progression During Endoplasmic Reticulum Stress

    Science.gov (United States)

    Rozpędek, W.; Pytel, D.; Mucha, B.; Leszczyńska, H.; Diehl, J. Alan; Majsterek, I.

    2016-01-01

    Hypoxia is a major hallmark of the tumor microenvironment that is strictly associated with rapid cancer progression and induction of metastasis. Hypoxia inhibits disulfide bond formation and impairs protein folding in the Endoplasmic Reticulum (ER). The stress in the ER induces the activation of Unfolded Protein Response (UPR) pathways via the induction of protein kinase RNA-like endoplasmic reticulum kinase (PERK). As a result, the level of phosphorylated Eukaryotic Initiation Factor 2 alpha (eIF2α) is markedly elevated, resulting in the promotion of a pro-adaptive signaling pathway by the inhibition of global protein synthesis and selective translation of Activating Transcription Factor 4 (ATF4). On the contrary, during conditions of prolonged ER stress, pro-adaptive responses fail and apoptotic cell death ensues. Interestingly, similar to the activity of the mitochondria, the ER may also directly activate the apoptotic pathway through ER stress-mediated leakage of calcium into the cytoplasm that leads to the activation of death effectors. Apoptotic cell death also ensues by ATF4-CHOP- mediated induction of several pro-apoptotic genes and suppression of the synthesis of anti-apoptotic Bcl-2 proteins. Advancing molecular insight into the transition of tumor cells from adaptation to apoptosis under hypoxia-induced ER stress may provide answers on how to overcome the limitations of current anti-tumor therapies. Targeting components of the UPR pathways may provide more effective elimination of tumor cells and as a result, contribute to the development of more promising anti-tumor therapeutic agents. PMID:27211800

  17. Achievement of ultra-low emittance beam in the ATF damping ring

    CERN Document Server

    Honda, Y; Araki, S; Bane, Karl Leopold Freitag; Brachmann, A; Frisch, J; Fukuda, M; Hasegawa, K; Hayano, H; Hendrickson, L; Higashi, Y; Higo, T; Hirano, K; Hirose, T; Iida, K; Imai, T; Inoue, Y; Karataev, P; Kubo, K; Kurihara, Y; Kuriki, M; Kuroda, R; Kuroda, S; Luo, X; Matsuda, M; McCormick, D; Muto, T; Nakajima, K; Nelson, J; Nomura, M; Ohashi, A; Okugi, T; Omori, T; Ross, M; Sakai, H; Sakai, I; Sasao, N; Smith, S; Suzuki, T; Takano, M; Takashi, N; Taniguchi, T; Terunuma, N; Toge, N; Turner, J; Urakawa, J; Vogel, V; Wolski, A; Woodley, M; Yamazaki, I; Yamazaki, Y; Yocky, J; Young, A; Zimmermann, Frank

    2003-01-01

    We report on the smallest vertical emittance achieved in single-bunch-mode operation of the ATF. The emittances were measured with a laser-wire beam-profile monitor installed in the damping ring. The bunch length and the momentum spread of the beam were also recorded under the same conditions. The smallest vertical rms emittance measured is 4 pm in the limit of zero current. It increases by a factor of 1.5 for a bunch intensity of 10^10 electrons. There are no discrepancies between the measured data and the calculations of intra-beam scattering.

  18. Pancreatic β-cells activate a JunB/ATF3-dependent survival pathway during inflammation

    DEFF Research Database (Denmark)

    Gurzov, E N; Barthson, J; Marhfour, I;

    2012-01-01

    Destruction of insulin-producing pancreatic β-cells by local autoimmune inflammation is a hallmark of type 1 diabetes. Histochemical analysis of pancreases from non-obese diabetic mice indicated activation of the transcription factor JunB/AP-1 (activator protein-1) after autoimmune infiltration of...... primary β-cells and human islet cells against pro-inflammatory mediators. These results were confirmed in genetically modified islets derived from Ubi-JunB transgenic mice. Our findings identify ATF3 as a novel downstream target of JunB in the survival mechanism of β-cells under inflammatory stress....

  19. Development and quality assessments of commercial heat production of ATF FeCrAl tubes

    Energy Technology Data Exchange (ETDEWEB)

    Yamamoto, Yukinori [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2015-09-01

    Development and quality assessment of the 2nd generation ATF FeCrAl tube production with commercial manufacturers were conducted. The manufacturing partners include Sophisticated Alloys, Inc. (SAI), Butler, PA for FeCrAl alloy casting via vacuum induction melting, Oak Ridge National Laboratory (ORNL) for extrusion process to prepare the master bars/tubes to be tube-drawn, and Rhenium Alloys, Inc. (RAI), North Ridgeville, OH, for tube-drawing process. The masters bars have also been provided to Los Alamos National Laboratory (LANL) who works with Century Tubes, Inc., (CTI), San Diego, CA, as parallel tube production effort under the current program.

  20. Tests of the FONT3 Linear Collider Intra-Train Beam Feedback System at the ATF

    International Nuclear Information System (INIS)

    We report preliminary results of beam tests of the FONT3 Linear Collider intra-train position feedback system prototype at the Accelerator Test Facility at KEK. The feedback system incorporates a novel beam position monitor (BPM) processor with a latency below 5 nanoseconds, and a kicker driver amplifier with similar low latency. The 56 nanosecond-long bunchtrain in the ATF extraction line was used to test the prototype BPM processor. The achieved latency will allow a demonstration of intra-train feedback on timescales relevant even for the CLIC Linear Collider design

  1. Experiments on large superconducting toroidal coil in LCT

    International Nuclear Information System (INIS)

    The experiment on Large Coil Task (LCT) project which is the works of developing the superconductive coils for nuclear fusion, and has been advanced centering around IEA, was successfully completed on September 3, 1987. In these works which were accompanied by huge hardwares and took 10 years, the contents of the experiment carried out in the Oak Ridge National Laboratory in USA, which was the highlight, and the perspective of the evaluation are described. This paper is intended to let those concerned with the technical development of atomic energy understand the experimental results of LCT coils and the contents of the development of large scale technology. The fundamental constitution of the LCT is as follows. ORNL determined the specification of the performance of superconductive toroidal coils. The participants decided their own specification of the construction. The coils were assembled in torus form, and the aptitude of the construction and materials was tested and evaluated under the same condition. The features of six coils made in USA, Euratom, Switzerland and Japan, the experimental items and the most difficult points, the results of precooling and temperature rise, the characteristics of the Japanese coil, the general comparison of six coils, and the technical problems surrounding coils are reported. (Kako, I.)

  2. Progress on Thomson scattering in the Pegasus Toroidal Experiment

    International Nuclear Information System (INIS)

    A novel Thomson scattering system has been implemented on the Pegasus Toroidal Experiment where typical densities of 1019 m−3 and electron temperatures of 10 to 500 eV are expected. The system leverages technological advances in high-energy pulsed lasers, volume phase holographic (VPH) diffraction gratings, and gated image intensified (ICCD) cameras to provide a relatively low-maintenance, economical, robust diagnostic system. Scattering is induced by a frequency-doubled, Q-switched Nd:YAG laser (2 J at 532 nm, 7 ns FWHM pulse) directed to the plasma over a 7.7 m long beam path, and focused to 80%) and fast-gated ICCDs (gate > 2 ns, Gen III intensifier) with high-throughput (F/1.8), achromatic lensing. A stray light mitigation facility has been implemented, consisting of a multi-aperture optical baffle system and a simple beam dump. Successful stray light reduction has enabled detection of scattered signal, and Rayleigh scattering has been used to provide a relative calibration. Initial temperature measurements have been made and data analysis algorithms are under development

  3. Latest Performance Results from the FONT5 Intra-train Beam Position and Angle Feedback System at ATF2

    CERN Document Server

    Christian, G B; Bett, D R; Blaskovic Kraljevic, N; Burrows, P N; Davis, M R; Gerbershagen, A; Perry, C; Constance, B; Resta-Lopez, J

    2012-01-01

    A prototype Interaction Point beam-based feedback system for future electron-positron colliders, such as the International Linear Collider, has been designed and tested on the extraction line of the KEK Accelerator Test Facility (ATF). The FONT5 intra-train feedback system aims to stabilize the beam orbit by correcting both the position and angle jitter in the vertical plane on bunch-tobunch time scales, providing micron-level stability at the entrance to the ATF2 final-focus system. The system comprises three stripline beam position monitors (BPMs) and two stripline kickers, custom low-latency analogue front-end BPM processors, a custom FPGA-based digital processing board with fast ADCs, and custom kickerdrive amplifiers. The latest results from beam tests at ATF2 will be presented, including the system latency and correction performance.

  4. Kinetic effect of toroidal rotation on the geodesic acoustic mode

    Energy Technology Data Exchange (ETDEWEB)

    Guo, W., E-mail: wfguo@ipp.ac.cn; Ye, L.; Zhou, D.; Xiao, X. [Institute of Plasma Physics, Chinese Academy of Science, Hefei, Anhui 230031 (China); Wang, S. [Department of Modern Physics, University of Science and Technology of China, Hefei, Anhui 230026 (China)

    2015-01-15

    Kinetic effects of the toroidal rotation on the geodesic acoustic mode are theoretically investigated. It is found that when the toroidal rotation increases, the damping rate increases in the weak rotation regime due to the rotation enhancement of wave-particle interaction, and it decreases in the strong rotation regime due to the reduction of the number of resonant particles. Theoretical results are consistent with the behaviors of the geodesic acoustic mode recently observed in DIII-D and ASDEX-Upgrade. The kinetic damping effect of the rotation on the geodesic acoustic mode may shed light on the regulation of turbulence through the controlling the toroidal rotation.

  5. Toroidal dipole resonances in the relativistic random phase approximation

    CERN Document Server

    Vretenar, D; Ring, P

    2002-01-01

    The isoscalar toroidal dipole strength distributions in spherical nuclei are calculated in the framework of a fully consistent relativistic random phase approximation, based on effective mean-field Lagrangians with nonlinear meson self-interaction terms. It is suggested that the recently observed "low-lying component of the isoscalar dipole mode" might in fact correspond to the toroidal giant dipole resonance. Although predicted by several theoretical models, the existence of toroidal resonances has not yet been confirmed in experiment. In the present analysis the vortex dynamics of these states is displayed by the corresponding velocity fields.

  6. Laser-induced production of large carbon-based toroids

    International Nuclear Information System (INIS)

    We report on the production of large carbon-based toroids (CBTs) from fullerenes. The process involves two-step laser irradiation of a mixed fullerene target (76% C60, 22% C70). Transmission electron microscopy (TEM) clearly identifies toroidal-shaped structures as well as Q-shaped constructs. The typical diameters of the CBTs are ∼0.2-0.3 μm with tubular diameters of ∼50-100 nm, but toroids as wide as 0.5 μm are observed making them nanostructures on the verge of being microstructures

  7. Toroidal Spiral Strings in Higher-dimensional Spacetime

    CERN Document Server

    Igata, Takahisa

    2010-01-01

    We report on our progress in research of separability of the Nambu-Goto equation for test strings with a symmetric configuration in a shape of toroidal spiral in a five-dimensional Kerr-AdS black hole. In particular, for a Hopf loop string which is a special class of the toroidal spirals, we show the complete separation of variables occurs in two cases, Kerr background and Kerr-AdS background with equal angular momenta. We also obtain the dynamical solution for the Hopf loop around a black hole and for the general toroidal spiral in Minkowski background.

  8. TGRL Lipolysis Products Induce Stress Protein ATF3 via the TGF-β Receptor Pathway in Human Aortic Endothelial Cells

    OpenAIRE

    Eiselein, Larissa; Nyunt, Tun; Lamé, Michael W.; Ng, Kit F.; Wilson, Dennis W.; Rutledge, John C; Hnin H Aung

    2015-01-01

    Studies have suggested a link between the transforming growth factor beta 1 (TGF-β1) signaling cascade and the stress-inducible activating transcription factor 3 (ATF3). We have demonstrated that triglyceride-rich lipoproteins (TGRL) lipolysis products activate MAP kinase stress associated JNK/c-Jun pathways resulting in up-regulation of ATF3, pro-inflammatory genes and induction of apoptosis in human aortic endothelial cells. Here we demonstrate increased release of active TGF-β at 15 min, p...

  9. Performance of the FONT3 Fast Analogue Intra-Train Beam-Based Feedback System at ATF

    International Nuclear Information System (INIS)

    We report results of beam tests of the FONT3 intra-train position feedback system prototype at the Accelerator Test Facility (ATF) at KEK. The feedback system incorporates a novel beam position monitor (BPM) processor with latency below 5 nanoseconds, and a kicker driver amplifier with similar low latency. The 56 nanosecond-long bunchtrain in the ATF extraction line was used to test the prototype feedback system. The achieved latency of 23ns provides a demonstration of intra-train feedback on very short timescales relevant even for the CLIC Linear Collider design

  10. Preliminary neutronic assessment for ATF (Accident Tolerant Fuel) based on iron alloy

    Energy Technology Data Exchange (ETDEWEB)

    Abe, Alfredo, E-mail: ayabe@ipen.br [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil); Carluccio, Thiago; Piovezan, Pamela [Centro Tecnologico da Marinha em Sao Paulo (CTMSP), SP (Brazil). Departamento de Reatores; Giovedi, Claudia; Martins, Marcelo R. [Universidade de Sao Paulo (POLI/USP), SP (Brazil). Lab. de Analise, Avaliacao e Gerenciamento de Risco

    2015-07-01

    After Fukushima Daiichi nuclear accident in 2011, the nuclear fuel performance under accident condition became a very important issue and currently different research and development program are in progress toward to reliability and withstand under accident condition. These initiatives are known as ATF (Accident Tolerant Fuel) R and D program, which many countries with different research institutes, fuel vendors and others are nowadays involved. Accident Tolerant Fuel (ATF) can be defined as enhanced fuel which can tolerate loss of active cooling system capability for a considerably longer time period and the fuel/cladding system can be maintained without significant degradation and can also improve the fuel performance during normal operations and transients, as well as design-basis accident (DBA) and beyond design-basis (BDBA) accident. Different materials have being proposed as fuel cladding candidates considering thermo-mechanical properties and lower reaction kinetic with steam and slower hydrogen production. The aim of this work is to perform a neutronic assessment for several cladding candidates based on iron alloy considering a standard PWR fuel rod (fuel pellet and dimension). The purpose of the assessment is to address different parameters that might contribute for possible neutronic reactivity gain in order to overcome the penalty due to increase of neutron absorption in the cladding materials. All the neutronic assessment is performed using MCNP, Monte Carlo code. (author)

  11. Limited ATF4 Expression in Degenerating Retinas with Ongoing ER Stress Promotes Photoreceptor Survival in a Mouse Model of Autosomal Dominant Retinitis Pigmentosa

    Science.gov (United States)

    Bhootada, Yogesh; Kotla, Pravallika; Zolotukhin, Sergei; Gorbatyuk, Oleg; Bebok, Zsuzsanna; Athar, Mohammad; Gorbatyuk, Marina

    2016-01-01

    T17M rhodopsin expression in rod photoreceptors leads to severe retinal degeneration and is associated with the activation of ER stress related Unfolded Protein Response (UPR) signaling. Here, we show a novel role of a UPR transcription factor, ATF4, in photoreceptor cellular pathology. We demonstrated a pro-death role for ATF4 overexpression during autosomal dominant retinitis pigmentosa (ADRP). Based on our results in ATF4 knockout mice and adeno-associated viral (AAV) delivery of ATF4 to the retina, we validated a novel therapeutic approach targeting ATF4 over the course of retinal degeneration. In T17M rhodopsin retinas, we observed ATF4 overexpression concomitantly with reduction of p62 and elevation of p53 levels. These molecular alterations, together with increased CHOP and caspase-3/7 activity, possibly contributed to the mechanism of photoreceptor cell loss. Conversely, ATF4 knockdown retarded retinal degeneration in 1-month-old T17M Rhodopsin mice and promoted photoreceptor survival, as measured by scotopic and photopic ERGs and photoreceptor nuclei row counts. Similarly, ATF4 knockdown also markedly delayed retinal degeneration in 3-month-old ADRP animals. This delay was accompanied by a dramatic decrease in UPR signaling, the launching of anti-oxidant defense, initiation of autophagy, and improvement of rhodopsin biosynthesis which together perhaps combat the cellular stress associated with T17M rhodopsin. Our data indicate that augmented ATF4 signals during retinal degeneration plays a cytotoxic role by triggering photoreceptor cell death. Future ADRP therapy regulating ATF4 expression can be developed to treat retinal degenerative disorders associated with activated UPR. PMID:27144303

  12. Influence of toroidal rotation on resistive tearing modes in tokamaks

    International Nuclear Information System (INIS)

    Influence of toroidal equilibrium plasma rotation on m/n = 2/1 resistive tearing modes is studied numerically using a 3D toroidal MHD code (CLT). It is found that the toroidal rotation with or without shear can suppress the tearing instability and the Coriolis effect in the toroidal geometry plays a dominant role on the rotation induced stabilization. For a high viscosity plasma (τR/τV ≫ 1, where τR and τV represent resistive and viscous diffusion time, respectively), the effect of the rotation shear combined with the viscosity appears to be stabilizing. For a low viscosity plasmas (τR/τV ≪ 1), the rotation shear shows a destabilizing effect when the rotation is large

  13. Influence of toroidal rotation on resistive tearing modes in tokamaks

    Science.gov (United States)

    Wang, S.; Ma, Z. W.

    2015-12-01

    Influence of toroidal equilibrium plasma rotation on m/n = 2/1 resistive tearing modes is studied numerically using a 3D toroidal MHD code (CLT). It is found that the toroidal rotation with or without shear can suppress the tearing instability and the Coriolis effect in the toroidal geometry plays a dominant role on the rotation induced stabilization. For a high viscosity plasma (τR/τV ≫ 1, where τR and τV represent resistive and viscous diffusion time, respectively), the effect of the rotation shear combined with the viscosity appears to be stabilizing. For a low viscosity plasmas (τR/τV ≪ 1), the rotation shear shows a destabilizing effect when the rotation is large.

  14. Influence of toroidal rotation on resistive tearing modes in tokamaks

    Energy Technology Data Exchange (ETDEWEB)

    Wang, S.; Ma, Z. W., E-mail: zwma@zju.edu.cn [Institute for Fusion Theory and Simulation, Zhejiang University, Hangzhou 310027 (China)

    2015-12-15

    Influence of toroidal equilibrium plasma rotation on m/n = 2/1 resistive tearing modes is studied numerically using a 3D toroidal MHD code (CLT). It is found that the toroidal rotation with or without shear can suppress the tearing instability and the Coriolis effect in the toroidal geometry plays a dominant role on the rotation induced stabilization. For a high viscosity plasma (τ{sub R}/τ{sub V} ≫ 1, where τ{sub R} and τ{sub V} represent resistive and viscous diffusion time, respectively), the effect of the rotation shear combined with the viscosity appears to be stabilizing. For a low viscosity plasmas (τ{sub R}/τ{sub V} ≪ 1), the rotation shear shows a destabilizing effect when the rotation is large.

  15. Effect of toroidicity during lower hybrid mode conversion

    International Nuclear Information System (INIS)

    The effect of toroidicity during lower hybrid mode conversion is examined by treating the wave propagation in an inhomogeneous medium as an eigenvalue problem for ω2(m,n),m,n poloidal and toroidal wave numbers. Since the frequency regime near ω2 = ω/sub LH/2 is an accumulation point for the eigenvalue spectrum, the degenerate perturbation technique must be applied. The toroidal eigenmodes are constructed by a zeroth order superposition of monochromatic solutions with different poloidal dependence m, thus they generically exhibit a wide spectrum in k/sub parallel/ for given fixed ω2 even for small inverse aspect ratio epsilon. In case that the average is in the neighborhood of k/sub min/, the minimum wave number for accessibility of the mode conversion regime, it is expected that excitation of toroidal modes rather than geometric optics will determine the wave coupling to the plasma

  16. Turbulent and neoclassical toroidal momentum transport in tokamak plasmas

    International Nuclear Information System (INIS)

    The goal of magnetic confinement devices such as tokamaks is to produce energy from nuclear fusion reactions in plasmas at low densities and high temperatures. Experimentally, toroidal flows have been found to significantly improve the energy confinement, and therefore the performance of the machine. As extrinsic momentum sources will be limited in future fusion devices such as ITER, an understanding of the physics of toroidal momentum transport and the generation of intrinsic toroidal rotation in tokamaks would be an important step in order to predict the rotation profile in experiments. Among the mechanisms expected to contribute to the generation of toroidal rotation is the transport of momentum by electrostatic turbulence, which governs heat transport in tokamaks. Due to the low collisionality of the plasma, kinetic modeling is mandatory for the study of tokamak turbulence. In principle, this implies the modeling of a six-dimensional distribution function representing the density of particles in position and velocity phase-space, which can be reduced to five dimensions when considering only frequencies below the particle cyclotron frequency. This approximation, relevant for the study of turbulence in tokamaks, leads to the so-called gyrokinetic model and brings the computational cost of the model within the presently available numerical resources. In this work, we study the transport of toroidal momentum in tokamaks in the framework of the gyrokinetic model. First, we show that this reduced model is indeed capable of accurately modeling momentum transport by deriving a local conservation equation of toroidal momentum, and verifying it numerically with the gyrokinetic code GYSELA. Secondly, we show how electrostatic turbulence can break the axisymmetry and generate toroidal rotation, while a strong link between turbulent heat and momentum transport is identified, as both exhibit the same large-scale avalanche-like events. The dynamics of turbulent transport are

  17. Low-aspect-ratio toroidal equilibria of electron clouds

    International Nuclear Information System (INIS)

    Toroidal electron clouds with a low aspect ratio (as small as 1.3) and lasting for thousands of poloidal rotation periods have been formed in the laboratory. Characteristic toroidal effects like a large inward shift of the minor axis of equipotential contours, elliptical and triangular deformations, etc., have been observed experimentally for the first time. The results of new analytic and numerical investigations of low-aspect-ratio electron cloud equilibria, which reproduce many of the observed features, are also presented

  18. Effective toroidal curvature and error field on NBT

    International Nuclear Information System (INIS)

    The effective toroidal curvature and the poloidal drift velocity for transit electrons with v sub(parallel)/v = 1 are measured for NBT-I device by use of an electron beam probing. The axis of the drift surfaces shifts inward by 12 cm due to the toroidal effect. The error field averaged along the torus is found to be spatially varying and is 1.1 x 10-3 at the minor axis. (author)

  19. Numerical solution of quasilinear kinetic diffusion equations in toroidal plasmas

    OpenAIRE

    Höök, Lars Josef

    2013-01-01

    One of the main challenges for the realization of a working fusion power plant is an increased detailed understanding of kinetic phenomena in toroidal plasmas. The tokamak is a toroidal, magnetically confined plasma device and is currently the main line towards a power plant. The spatial and temporal scales in a tokamak plasma are extreme and the only tractable path for quantitative studies is to rely on computer simulations. Present day simulation codes can resolve only some of these scales....

  20. Efficient magnetic fields for supporting toroidal plasmas

    Science.gov (United States)

    Landreman, Matt; Boozer, Allen H.

    2016-03-01

    The magnetic field that supports tokamak and stellarator plasmas must be produced by coils well separated from the plasma. However, the larger the separation, the more difficult it is to produce a given magnetic field in the plasma region, so plasma configurations should be chosen that can be supported as efficiently as possible by distant coils. The efficiency of an externally generated magnetic field is a measure of the field's shaping component magnitude at the plasma compared to the magnitude near the coils; the efficiency of a plasma equilibrium can be measured using the efficiency of the required external shaping field. Counterintuitively, plasma shapes with low curvature and spectral width may have low efficiency, whereas plasma shapes with sharp edges may have high efficiency. Two precise measures of magnetic field efficiency, which correctly identify such differences in difficulty, will be examined. These measures, which can be expressed as matrices, relate the externally produced normal magnetic field on the plasma surface to the either the normal field or current on a distant control surface. A singular value decomposition (SVD) of either matrix yields an efficiency ordered basis for the magnetic field distributions. Calculations are carried out for both tokamak and stellarator cases. For axisymmetric surfaces with circular cross-section, the SVD is calculated analytically, and the range of poloidal and toroidal mode numbers that can be controlled to a given desired level is determined. If formulated properly, these efficiency measures are independent of the coordinates used to parameterize the surfaces.

  1. Toroidal nanotraps for cold polar molecules

    Science.gov (United States)

    Salhi, Marouane; Passian, Ali; Siopsis, George

    2015-09-01

    Electronic excitations in metallic nanoparticles in the optical regime that have been of great importance in surface-enhanced spectroscopy and emerging applications of molecular plasmonics, due to control and confinement of electromagnetic energy, may also be of potential to control the motion of nanoparticles and molecules. Here, we propose a concept for trapping polarizable particles and molecules using toroidal metallic nanoparticles. Specifically, gold nanorings are investigated for their scattering properties and field distribution to computationally show that the response of these optically resonant particles to incident photons permit the formation of a nanoscale trap when proper aspect ratio, photon wavelength, and polarization are considered. However, interestingly the resonant plasmonic response of the nanoring is shown to be detrimental to the trap formation. The results are in good agreement with analytic calculations in the quasistatic limit within the first-order perturbation of the scalar electric potential. The possibility of extending the single nanoring trapping properties to two-dimensional arrays of nanorings is suggested by obtaining the field distribution of nanoring dimers and trimers.

  2. Experimental study of high beta toroidal plasmas

    International Nuclear Information System (INIS)

    Experiments on the Wisconsin Levitated Toroidal Octupole have produced a wide range of stable high β plasmas with β significantly above single fluid MHD theory predictions. A stable β approx. 8% plasma, twice the fluid limit, is obtained with 5 rho/sub i/ approx. L/sub n/ and tau/sub β/ approx. = 6000 tau/sub Alfven/ = 600 μsec. The enhanced stability is explained with a kinetic treatment that includes the effect of finite ion gyroradius which couples the ballooning mode to an ion drift wave. In a more collisional, large gyroradius (2 rho/sub i/ approx. L/sub n/) regime, a stable β approx. 35% plasma is obtained with a decay time of 1000 Alfven times. Measurement of the equilibrium magnetic field in this regime indicates that the diamagnetic current density is five times smaller than predicted by ideal MHD, probably due to ion gyroviscosity. Particle transport is anomalous and ranges from agreement with the classical diffusion rate at the highest beta, lowest field plasma (B/sub P/ = 200 G), to thirteen times the classical rate in a β=11%, high field plasma (B/sub P/ = 860 G) where the level of enhancement increase with magnetic field. Fluctuations in density, electrostatic potential, and magnetic field have been studied in plasmas with β from 0.1% to 40%

  3. Sawtooth Instability in the Compact Toroidal Hybrid

    Science.gov (United States)

    Herfindal, J. L.; Maurer, D. A.; Hartwell, G. J.; Ennis, D. A.; Knowlton, S. F.

    2015-11-01

    Sawtooth instabilities have been observed in the Compact Toroidal Hybrid (CTH), a current-carrying stellarator/tokamak hybrid device. The sawtooth instability is driven by ohmic heating of the core plasma until the safety factor drops below unity resulting in the growth of an m = 1 kink-tearing mode. Experiments varying the vacuum rotational transform from 0.02 to 0.13 are being conducted to study sawtooth property dependance on vacuum flux surface structure. The frequency of the sawtooth oscillations increase from 2 kHz to 2.8 kHz solely due the decrease in rise time of the oscillation, the crash time is unchanged. CTH has three two-color SXR cameras, a three-channel 1mm interferometer, and a new bolometer system capable of detecting the signatures of sawtooth instabilities. The new bolometer system consists of two cameras, each containing a pair of diode arrays viewing the plasma directly or through a beryllium filter. Electron temperature measurements are found with the two-color SXR cameras through a ratio of the SXR intensities. Impurity radiation can drastically affect the electron temperature measurement, therefore new filters consisting of aluminum and carbon were selected to avoid problematic line radiation while maximizing the signal for a 100 eV plasma. This work is supported by U.S. Department of Energy Grant No. DE-FG02-00ER54610.

  4. Ballooning mode spectrum in general toroidal systems

    Energy Technology Data Exchange (ETDEWEB)

    Dewar, R.L.; Glasser, A.H.

    1982-04-01

    A WKB formalism for constructing normal modes of short-wavelength ideal hydromagnetic, pressure-driven instabilities (ballooning modes) in general toroidal magnetic containment devices with sheared magnetic fields is developed. No incompressibility approximation is made. A dispersion relation is obtained from the eigenvalues of a fourth order system of ordinary differential equations to be solved by integrating along a line of force. Higher order calculations are performed to find the amplitude equation and the phase change at a caustic. These conform to typical WKB results. In axisymmetric systems, the ray equations are integrable, and semiclassical quantization leads to a growth rate spectrum consisting of an infinity of discrete eigenvalues, bounded above by an accumulation point. However, each eigenvalue is infinitely degenerate. In the nonaxisymmetric case, the rays are unbounded in a four dimensional phase space, and semiclassical quantization breaks down, leading to broadening of the discrete eigenvalues and accumulation point of the axisymmetric case into continuum bands. Analysis of a model problem indicates that the broadening of the discrete eigenvalues is numerically very small, the dominant effect being broadening of the accumulation point.

  5. Tearing Mode Stability of Evolving Toroidal Equilibria

    Science.gov (United States)

    Pletzer, A.; McCune, D.; Manickam, J.; Jardin, S. C.

    2000-10-01

    There are a number of toroidal equilibrium (such as JSOLVER, ESC, EFIT, and VMEC) and transport codes (such as TRANSP, BALDUR, and TSC) in our community that utilize differing equilibrium representations. There are also many heating and current drive (LSC and TORRAY), and stability (PEST1-3, GATO, NOVA, MARS, DCON, M3D) codes that require this equilibrium information. In an effort to provide seamless compatibility between the codes that produce and need these equilibria, we have developed two Fortran 90 modules, MEQ and XPLASMA, that serve as common interfaces between these two classes of codes. XPLASMA provides a common equilibrium representation for the heating and current drive applications while MEQ provides common equilibrium and associated metric information needed by MHD stability codes. We illustrate the utility of this approach by presenting results of PEST-3 tearing stability calculations of an NSTX discharge performed on profiles provided by the TRANSP code. Using the MEQ module, the TRANSP equilibrium data are stored in a Fortran 90 derived type and passed to PEST3 as a subroutine argument. All calculations are performed on the fly, as the profiles evolve.

  6. Pseudo-Anosov flows in toroidal manifolds

    CERN Document Server

    Barbot, Thierry

    2010-01-01

    We first prove rigidity results for pseudo-Anosov flows in prototypes of toroidal 3-manifolds: we show that a pseudo-Anosov in a Seifert fibered manifold is up to finite covers topologically conjugate to a geodesic flow. We also show that a pseudo-Anosov flow in a solv manifold is topologically conjugate to a suspension Anosov flow. Then we analyse immersed and embedded incompressible tori in optimal position with respect to a pseudo-Anosov flow. We also study the interaction of a pseudo-Anosov flow with possible Seifert fibered pieces in the torus decomposition: if the fiber is associated to a periodic orbit of the flow, we produce a standard form for the flow in the piece using Birkhoff annuli. Finally we introduce several new classes of examples, some of which are generalized pseudo-Anosov flows which have one prong singularities. The examples show that the results above in Seifert fibered and solvable manifolds do not apply to one prong pseudo-Anosov flows. In addition we also construct a large new class ...

  7. ''Turbulent Equipartition'' Theory of Toroidal Momentum Pinch

    International Nuclear Information System (INIS)

    The mode-independent part of magnetic curvature driven turbulent convective (TuroCo) pinch of the angular momentum density (Hahm et al., Phys. Plasmas 14,072302 (2007)) which was originally derived from the gyrokinetic equation, can be interpreted in terms of the turbulent equipartition (TEP) theory. It is shown that the previous results can be obtained from the local conservation of 'magnetically weighted angular momentum density', nmi U#parallel# R/B2, and its homogenization due to turbulent flows. It is also demonstrated that the magnetic curvature modification of the parallel acceleration in the nonlinear gyrokinetic equation in the laboratory frame, which was shown to be responsible for the TEP part of the TurCo pinch of angular momentum density in the previous work, is closely related to the Coriolis drift coupling to the perturbed electric field. In addition, the origin of the diffusive flux in the rotating frame is highlighted. Finally, it is illustrated that there should be a difference in scalings between the momentum pinch originated from inherently toroidal effects and that coming from other mechanisms which exist in a simpler geometry.

  8. Turbulent Equipartition Theory of Toroidal Momentum Pinch

    Energy Technology Data Exchange (ETDEWEB)

    T.S. Hahm, P.H. Diamond, O.D. Gurcan, and G. Rewaldt

    2008-01-31

    The mode-independet part of magnetic curvature driven turbulent convective (TuroCo) pinch of the angular momentum density [Hahm et al., Phys. Plasmas 14,072302 (2007)] which was originally derived from the gyrokinetic equation, can be interpreted in terms of the turbulent equipartition (TEP) theory. It is shown that the previous results can be obtained from the local conservation of "magnetically weighted angular momentum density," nmi U|| R/B2, and its homogenization due to turbulent flows. It is also demonstrated that the magnetic curvature modification of the parallel acceleration in the nonlinear gyrokinetic equation in the laboratory frame, which was shown to be responsible for the TEP part of the TurCo pinch of angular momentum density in the previous work, is closely related to the Coriolis drift coupling to the perturbed electric field. In addition, the origin of the diffusive flux in the rotating frame is highlighted. Finally, it is illustratd that there should be a difference in scalings between the momentum pinch originated from inherently toroidal effects and that coming from other mechanisms which exist in a simpler geometry.

  9. Confinement and heating of high beta plasma with emphasis on compact toroids. Compact toroid research

    International Nuclear Information System (INIS)

    Two older projects associated with very high energy density plasmas, specifically the High Density Field Reversed Configuration and the Liner Plasma Compression Experiment, have been completed. Attention has been turned to compact toroid experiments of more conventional density, and three experiments have been initiated. These include the Coaxial Slow Source Experiment, the Variable Length FRC Experiment, and Variable Angle CthetaP Experiment. In each case, the project was begun in order to provide basic plasma physics information on specific unresolved issues of progammatic importance to the national CT Program

  10. An important step for the ATLAS toroid magnet

    CERN Multimedia

    2000-01-01

    The ATLAS experiment's prototype toroid coil arrives at CERN from the CEA laboratory in Saclay on 6 October. The world's largest superconducting toroid magnet is under construction for the ATLAS experiment. A nine-metre long fully functional prototype coil was delivered to CERN at the beginning of October and has since been undergoing tests in the West Area. Built mainly by companies in France and Italy under the supervision of engineers from the CEA-Saclay laboratory near Paris and Italy's INFN-LASA, the magnet is a crucial step forward in the construction of the ATLAS superconducting magnet system. Unlike any particle detector that has gone before, the ATLAS detector's magnet system consists of a large toroidal system enclosing a small central solenoid. The barrel part of the toroidal system will use eight toroid coils, each a massive 25 metres in length. These will dwarf the largest toroids in the world when ATLAS was designed, which measure about six metres. So the ATLAS collaboration decided to build a...

  11. Toroidal Momentum Pinch Velocity due to the Coriolis Drift Effect on Small Scale Instabilities in a Toroidal Plasma

    International Nuclear Information System (INIS)

    In this Letter, the influence of the ''Coriolis drift'' on small scale instabilities in toroidal plasmas is shown to generate a toroidal momentum pinch velocity. Such a pinch results because the Coriolis drift generates a coupling between the density and temperature perturbations on the one hand and the perturbed parallel flow velocity on the other. A simple fluid model is used to highlight the physics mechanism and gyro-kinetic calculations are performed to accurately assess the magnitude of the pinch. The derived pinch velocity leads to a radial gradient of the toroidal velocity profile even in the absence of a torque on the plasma and is predicted to generate a peaking of the toroidal velocity profile similar to the peaking of the density profile. Finally, the pinch also affects the interpretation of current experiments

  12. 28 CFR 16.106 - Exemption of the Bureau of Alcohol, Tobacco, Firearms, and Explosives (ATF)-Limited Access.

    Science.gov (United States)

    2010-07-01

    ... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Exemption of the Bureau of Alcohol, Tobacco, Firearms, and Explosives (ATF)-Limited Access. 16.106 Section 16.106 Judicial Administration... interpreted to require more detail as to the identity of sources of the records in these systems,...

  13. MiR-214 regulates the function of osteoblast under simulated microgravity by targeting ATF4

    Science.gov (United States)

    Li, Yingxian; Wang, Xiaogang; Li, Qi; Lv, Ke; Wan, Yumin; Li, Yinghui; Bai, Yanqiang

    Background: MicroRNAs (miRNAs) are small fragments of single-stranded RNA containing 18-24 nucleotides, and are generated from endogenous transcripts. MicroRNAs function in post-transcriptional gene silencing by targeting the 3'-untranslated region (UTR) of mRNAs, resulting in translational repression. Growing evidence shows that microRNAs (miRNAs) regu-late various developmental and homeostatic events in vertebrates and invertebrates. Osteoblast differentiation is a key step in proper skeletal development and acquisition of bone mass; How-ever, the physiological role of non-coding small RNAs, especially miRNAs, in osteoblast dif-ferentiation remains elusive. Methods: To study the potential involvement of miRNAs in osteoblast differentiation under stimulated microgravity, we analyzed the expression of 20 bone relative miRNAs using real time PCR platform to find particularly miRNAs whose expression is altered during osteoblast differentiation. TargetScan, miRBase and Miranda were used to predict the target gene of candidate miRNA. To investigate whether ATF4 can be directly targeted by miR-214, we engineered luciferase reporters that have either the wild-type 3'UTRs of these genes, or the mutant UTRs with a 6 base pair (bp) deletion in the target sites. Lastly, to address the in vivo role of miR-214 in bone formation, tail suspension mice model was used to simulate the change of osteoblast function and bone loss. Results: Recent studies have sug-gested that miRNAs might play a role in osteoblast differentiation and bone formation. Here, we identify miR-214 in MC3T3-E1 cells, which is a primary mouse osteoblasts cell line, to promote osteoblast differentiation by repressing Activating Transcription Factor4 (ATF4) ex-pression at the posttranscriptional level. What is more, miR-214 was found to be transcribed in C2C12 cells during bone morphogenetic protein 2-induced (BMP2-induced) osteogenesis, and overexpression of miR-214 attenuated BMP2-induced osteoblastogenesis

  14. Emittance reconstruction from measured beam sizes in ATF2 and perspectives for ILC

    Science.gov (United States)

    Faus-Golfe, A.; Navarro, J.; Fuster Martinez, N.; Resta Lopez, J.; Giner Navarro, J.

    2016-05-01

    The projected emittance (2D) and the intrinsic emittance (4D) reconstruction method by using the beam size measurements at different locations is analyzed in order to study analytically the conditions of solvability of the systems of equations involved in this process. Some conditions are deduced and discussed, and general guidelines about the locations of the measurement stations have been obtained to avoid unphysical results. The special case of the multi-Optical Transition Radiation system (m-OTR), made of four measurement stations, in the Extraction Line (EXT) of Accelerator Test Facility 2 (ATF2) has been simulated in much detail and compared with measurements. Finally a feasibility study of a multi-station system for fast transverse beam size measurement, emittance reconstruction and coupling correction in the Ring to Main Linac (RTML) of International Linear Collider (ILC) Diagnostic sections of the RTML has been discussed in detail.

  15. Measured Thermal and Fast Neutron Fluence Rates for ATF-1 Holders During ATR Cycle 157D

    Energy Technology Data Exchange (ETDEWEB)

    Smith, Larry Don [Idaho National Lab. (INL), Idaho Falls, ID (United States); Miller, David Torbet [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2016-03-01

    This report contains the thermal (2200 m/s) and fast (E>1MeV) neutron fluence rate data for the ATF-1 holders located in core for ATR Cycle 157D which were measured by the Radiation Measurements Laboratory (RML) as requested by the Power Reactor Programs (ATR Experiments) Radiation Measurements Work Order. This report contains measurements of the fluence rates corresponding to the particular elevations relative to the 80-ft. core elevation. The data in this report consist of (1) a table of the ATR power history and distribution, (2) a hard copy listing of all thermal and fast neutron fluence rates, and (3) plots of both the thermal and fast neutron fluence rates. The fluence rates reported are for the average power levels given in the table of power history and distribution.

  16. Physics models in the toroidal transport code PROCTR

    Energy Technology Data Exchange (ETDEWEB)

    Howe, H.C.

    1990-08-01

    The physics models that are contained in the toroidal transport code PROCTR are described in detail. Time- and space-dependent models are included for the plasma hydrogenic-ion, helium, and impurity densities, the electron and ion temperatures, the toroidal rotation velocity, and the toroidal current profile. Time- and depth-dependent models for the trapped and mobile hydrogenic particle concentrations in the wall and a time-dependent point model for the number of particles in the limiter are also included. Time-dependent models for neutral particle transport, neutral beam deposition and thermalization, fusion heating, impurity radiation, pellet injection, and the radial electric potential are included and recalculated periodically as the time-dependent models evolve. The plasma solution is obtained either in simple flux coordinates, where the radial shift of each elliptical, toroidal flux surface is included to maintain an approximate pressure equilibrium, or in general three-dimensional torsatron coordinates represented by series of helical harmonics. The detailed coupling of the plasma, scrape-off layer, limiter, and wall models through the neutral transport model makes PROCTR especially suited for modeling of recycling and particle control in toroidal plasmas. The model may also be used in a steady-state profile analysis mode for studying energy and particle balances starting with measured plasma profiles.

  17. Physics models in the toroidal transport code PROCTR

    International Nuclear Information System (INIS)

    The physics models that are contained in the toroidal transport code PROCTR are described in detail. Time- and space-dependent models are included for the plasma hydrogenic-ion, helium, and impurity densities, the electron and ion temperatures, the toroidal rotation velocity, and the toroidal current profile. Time- and depth-dependent models for the trapped and mobile hydrogenic particle concentrations in the wall and a time-dependent point model for the number of particles in the limiter are also included. Time-dependent models for neutral particle transport, neutral beam deposition and thermalization, fusion heating, impurity radiation, pellet injection, and the radial electric potential are included and recalculated periodically as the time-dependent models evolve. The plasma solution is obtained either in simple flux coordinates, where the radial shift of each elliptical, toroidal flux surface is included to maintain an approximate pressure equilibrium, or in general three-dimensional torsatron coordinates represented by series of helical harmonics. The detailed coupling of the plasma, scrape-off layer, limiter, and wall models through the neutral transport model makes PROCTR especially suited for modeling of recycling and particle control in toroidal plasmas. The model may also be used in a steady-state profile analysis mode for studying energy and particle balances starting with measured plasma profiles

  18. Computer simulations of compact toroid formation and acceleration

    International Nuclear Information System (INIS)

    Experiments to form, accelerate, and focus compact toroid plasmas will be performed on the 9.4 MJ SHIVA STAR fast capacitor bank at the Air Force Weapons Laboratory during the 1990. The MARAUDER (magnetically accelerated rings to achieve ultrahigh directed energy and radiation) program is a research effort to accelerate magnetized plasma rings with the masses between 0.1 and 1.0 mg to velocities above 10 8 cm/sec and energies above 1 MJ. Research on these high-velocity compact toroids may lead to development of very fast opening switches, high-power microwave sources, and an alternative path to inertial confinement fusion. Design of a compact toroid accelerator experiment on the SHIVA STAR capacitor bank is underway, and computer simulations with the 2 1/2-dimensional magnetohydrodynamics code, MACH2, have been performed to guide this endeavor. The compact toroids are produced in a magnetized coaxial plasma gun, and the acceleration will occur in a configuration similar to a coaxial railgun. Detailed calculations of formation and equilibration of a low beta magnetic force-free configuration (curl B = kB) have been performed with MACH2. In this paper, the authors discuss computer simulations of the focusing and acceleration of the toroid

  19. Toroidal linear force-free magnetic fields with axial symmetry

    Science.gov (United States)

    Vandas, M.; Romashets, E.

    2016-01-01

    Aims: Interplanetary magnetic flux ropes are often described as linear force-free fields. To account for their curvature, toroidal configurations must be used. The aim is to find an analytic description of a linear force-free magnetic field of the toroidal geometry in which the cross section of flux ropes can be controlled. Methods: The solution is found as a superposition of fields given by linear force-free cylinders tangential to a generating toroid. The cylindrical field is expressed in a series of terms that are not all cylindrically symmetric. Results: We found the general form of a toroidal linear force-free magnetic field. The field is azimuthally symmetric with respect to the torus axis. It depends on a set of coefficients that enables controlling the flux rope shape (cross section) to some extent. By varying the coefficients, flux ropes with circular and elliptic cross sections were constructed. Numerical comparison suggests that the simple analytic formula for calculating the helicity in toroidal flux ropes of the circular cross section can be used for flux ropes with elliptic cross sections if the minor radius in the formula is set to the geometric mean of the semi-axes of the elliptic cross section.

  20. Optical toroidal dipolar response by an asymmetric double-bar metamaterial

    CERN Document Server

    Dong, Zheng-Gao; Rho, Junsuk; Li, Jia-Qi; Lu, Changgui; Yin, Xiaobo; Zhang, X; 10.1063/1.4757613

    2012-01-01

    We demonstrate that the toroidal dipolar response can be realized in the optical regime by designing a feasible nanostructured metamaterial, comprising asymmetric double-bar magnetic resonators assembled into a toroid-like configuration. It is confirmed numerically that an optical toroidal dipolar moment dominates over other moments. This response is characterized by a strong confinement of an E-field component at the toroid center, oriented perpendicular to the H-vortex plane. The resonance-enhanced optical toroidal response can provide an experimental avenue for various interesting optical phenomena associated with the elusive toroidal moment.

  1. Dynamics of the Disruption Halo Current Toroidal Asymmetry in NSTX

    Energy Technology Data Exchange (ETDEWEB)

    S.P. Gerhardt

    2012-09-27

    This paper describes the dynamics of disruption halo current non-axisymmetries in the lower divertor of the National Spherical Torus Experiment [M. Ono, et al. Nuclear Fusion 40, 557 (2000)]. While. The halo currents typically have a strongly asymmetric structure where they enter the divertor floor, and this asymmetry has been observed to complete up to 7 toroidal revolutions over the duration of the halo current pulse. However, the rotation speed and toroidal extend of the asymmetry can vary significantly during the pulse. The rotation speed, halo current pulse duration, and total number of revolutions tend to be smaller in cases with large halo currents. The halo current pattern is observed to become toroidally symmetric at the end of the halo current pulse. It is proposed that this symmeterization is due to the loss of most or all of the closed field line geometry in the final phase of the vertical displacement event.

  2. Toroidal drift waves with an equilibrium velocity field

    International Nuclear Information System (INIS)

    The author investigated the effect of a radially sheared poloidal velocity field on the toroidal drift wave which is well known to escape magnetic shear damping through toroidal coupling between different poloidal harmonics centered on individual rational surfaces. He endeavored to model the velocity profile according to that observed at the plasma edge during H-mode shots. The resultant wave formed by the interference of different poloidal harmonics now sees an antiwell created by the H-mode type velocity profile in the radial direction (in contrast to a well formed by the diamagnetic frequency in the absence of velocity fields). The wave, therefore, convects energy outward and hence undergoes damping. Outgoing wave boundary condition then introduces a negative imaginary contribution to the global eigenvalue -- once again confirming the stabilizing role of H-mode type velocity profiles. On the other hand, L-mode type velocity profiles have destabilizing action on toroidal drift waves

  3. Axion Haloscopes with Toroidal Geometry at CAPP/IBS

    CERN Document Server

    Ko, B R

    2016-01-01

    The present state of the art axion haloscope employs a cylindrical resonant cavity in a solenoidal field. We, the Center for Axion and Precision Physics Research (CAPP) of the Institute for Basic Science (IBS) in Korea, are also pursuing halo axion discovery using this cylindrical geometry. However, the presence of end caps of cavities increases challenges as we explore higher frequency regions for the axion at above 2 GHz. To overcome these challenges we exploit a toroidal design of cavity and magnetic field. A toroidal geometry offers several advantages, two of which are a larger volume for a given space and greatly reduced fringe fields which interfere with our preamps, in particular the planned quantum-based devices. We introduce the concept of toroidal axion haloscopes and present ongoing research activities and plans at CAPP/IBS.

  4. Reduction of toroidal ripple by using high Tc superconductors

    International Nuclear Information System (INIS)

    In this paper we present a new method to reduce the toroidal ripple with use of high Tc superconductors. High Tc superconductors can behave as ferromagnetic or diamagnetic materials depending on their magnetic hysteresis. If they are appropriately arranged and magnetized between the toroidal field coils, they possibly decrease the toroidal field ripple. Here, the preliminary design of ITER is taken as an example, and the effect of the high Tc superconductors on the ripple is evaluated. The magnetic induction due to the superconductors is calculated by the current vector potential method based on the critical state model. Several arrangements of the high Tc superconductors were quantitatively examined in order to reduce the ripple. The results obtained by the calculation show that the maximum ripple value can be reduced to be the required value. (orig.)

  5. Vlasov tokamak equilibria with shearad toroidal flow and anisotropic pressure

    Science.gov (United States)

    Throumoulopoulos, George; Kuiroukidis, Apostolos; Tasso, Henri

    2015-11-01

    By choosing appropriate deformed Maxwellian ion and electron distribution functions depending on the two particle constants of motion, i.e. the energy and toroidal angular momentum, we reduce the Vlasov axisymmetric equilibrium problem for quasineutral plasmas to a transcendental Grad-Shafranov-like equation. This equation is then solved numerically under the Dirichlet boundary condition for an analytically prescribed boundary possessing a lower X-point to construct tokamak equilibria with toroidal sheared ion flow and anisotropic pressure. Depending on the deformation of the distribution functions these steady states can have toroidal current densities either peaked on the magnetic axis or hollow. These two kinds of equilibria may be regarded as a bifurcation in connection with symmetry properties of the distribution functions on the magnetic axis. This work has received funding from (a) the National Programme for the Controlled Thermonuclear Fusion, Hellenic Republic, (b) Euratom research and training programme 2014-2018 under grant agreement No 633053.

  6. Vlasov tokamak equilibria with shearad toroidal flow and anisotropic pressure

    CERN Document Server

    Kuiroukidis, Ap; Tasso, H

    2015-01-01

    By choosing appropriate deformed Maxwellian ion and electron distribution functions depending on the two particle constants of motion, i.e. the energy and toroidal angular momentum, we reduce the Vlasov axisymmetric equilibrium problem for quasineutral plasmas to a transcendental Grad-Shafranov-like equation. This equation is then solved numerically under the Dirichlet boundary condition for an analytically prescribed boundary possessing a lower X-point to construct tokamak equilibria with toroidal sheared ion flow and anisotropic pressure. Depending on the deformation of the distribution functions these steady states can have toroidal current densities either peaked on the magnetic axis or hollow. These two kinds of equilibria may be regarded as a bifurcation in connection with symmetry properties of the distribution functions on the magnetic axis.

  7. Bi-2223 HTS winding in toroidal configuration for SMES coil

    Energy Technology Data Exchange (ETDEWEB)

    Kondratowicz-Kucewicz, B; Kozak, S; Kozak, J; Wojtasiewicz, G; Majka, M [Electrotechnical Institute in Warsaw (Poland); Janowski, T, E-mail: t.janowski@pollub.p [Lublin University of Technology (Poland)

    2010-06-01

    Energy can be stored in the magnetic field of a coil. Superconducting Magnetic Energy Storage (SMES) is very promising as a power storage system for load levelling or power stabilizer. However, the strong electromagnetic force caused by high magnetic field and large coil current is a problem in SMES systems. A toroidal configuration would have a much less extensive external magnetic field and electromagnetic forces in winding. The paper describes the design of HTS winding for SMES coil in modular toroid configuration consist of seven Bi-2223 double-pancakes as well as numerical analysis of SMES magnet model using FLUX 3D package. As the results of analysis the paper presents the optimal coil configuration and the parameters such as radius of toroidal magnet, energy stored in magnet and magnetic field distribution.

  8. Vlasov tokamak equilibria with sheared toroidal flow and anisotropic pressure

    Energy Technology Data Exchange (ETDEWEB)

    Kuiroukidis, Ap, E-mail: kouirouki@astro.auth.gr [Technological Education Institute of Serres, 62124 Serres (Greece); Throumoulopoulos, G. N., E-mail: gthroum@uoi.gr [Department of Physics, University of Ioannina, GR 451 10 Ioannina (Greece); Tasso, H., E-mail: het@ipp.mpg.de [Max-Planck-Institut für Plasmaphysik, D-85748 Garching (Germany)

    2015-08-15

    By choosing appropriate deformed Maxwellian ion and electron distribution functions depending on the two particle constants of motion, i.e., the energy and toroidal angular momentum, we reduce the Vlasov axisymmetric equilibrium problem for quasineutral plasmas to a transcendental Grad-Shafranov-like equation. This equation is then solved numerically under the Dirichlet boundary condition for an analytically prescribed boundary possessing a lower X-point to construct tokamak equilibria with toroidal sheared ion flow and anisotropic pressure. Depending on the deformation of the distribution functions, these steady states can have toroidal current densities either peaked on the magnetic axis or hollow. These two kinds of equilibria may be regarded as a bifurcation in connection with symmetry properties of the distribution functions on the magnetic axis.

  9. Linear wave propagation in a hot axisymmetric toroidal plasma

    International Nuclear Information System (INIS)

    Kinetic effects on the propagation of the Alfven wave are studied for the first time in a toroidal plasma relevant for experiments. This requires the resolution of a set of coupled partial differential equations whose coefficients depend locally on the plasma parameters. For this purpose, a numerical wave propagation code called PENN has been developed using either a bilinear or a bicubic Hermite finite element discretization. It solves Maxwell's equations in toroidal geometry, with a dielectric tensor operator that takes into account the linear response of the plasma. Two different models have been implemented and can be used comparatively to describe the same physical case: the first treats the plasma as resistive fluids and gives results which are in good agreement with toroidal fluid codes. The second is a kinetic model and takes into account the finite size of the Larmor radii; it has successfully been tested against a kinetic plasma model in cylindrical geometry. New results have been obtained when studying kinetic effects in toroidal geometry. Two different conversion mechanisms to the kinetic Alfven wave have been described: one occurs at toroidally coupled resonant surfaces and is the kinetic counterpart of the fluid models' resonance absorption. The other has no such correspondence and results directly from the toroidal coupling between the kinetic Alfven wave and the global wavefield. An analysis of a heating scenario suggests that it might be difficult to heat a plasma with Alfven waves up to temperatures that are relevant for a tokamak reactor. Kinetic effects are studied for three types of global Alfven modes (GAE, TAE, BAE) and a new class of kinetic eigenmodes is described which appear inside the fluid gap: it could be related to recent observations in the JET (Joint European Torus) tokamak. (author) 56 figs., 6 tabs., 58 refs

  10. On rotation of multi-species plasmas in toroidal systems

    International Nuclear Information System (INIS)

    This paper describes the poloidal and toroidal spin-up of an isothermal plasma in toroidal equilibria. The mechanism is the Stringer spin-up mechanism which will be generalized to an arbitrary toroidal equilibrium using the Hamada coordinate system. Viscous damping or magnetic pumping balances the accelerating forces and determines the threshold of spin-up. The accelerating forces arise from the Coriolis forces which couple the radial flow to the poloidal flow velocity. The theory presented here is a continuation of a previous paper and applies to a multi-species plasma with impurities. In the two-fluid model - or including impurities - in a multi-fluid model, the flux-friction relations derived on every magnetic surface are the basic equations for computing the poloidal and toroidal flow velocities of the particle species. Futhermore, the effect of turbulent forces on the mean flow is analysed. The Reynolds stresses resulting from anisotropic turbulence provide a force in the tangential direction and thus contribute to the poloidal and toroidal spin-up. Furthermore, turbulence increases the Stringer spin-up mechanism and introduces enhanced plasma losses. The final result is a set of differential equations describing the poloidal and toroidal flow on every magnetic surface. The formalism is valid in every regime of collisionality; however, to obtain specific results, appropriate appoximations must be found for every regime. This will be outlined for the collisional regime where the viscous forces are given by Braginskii's equations. The relation between plasma rotation and the zonal circulation in planetary atmospheres will be discussed. (Author)

  11. Toroidal vortices as a solution to the dust migration problem

    CERN Document Server

    Loren-Aguilar, Pablo

    2015-01-01

    In an earlier letter, we reported that dust settling in protoplanetary discs may lead to a dynamical dust-gas instability that produces global toroidal vortices. In this letter, we investigate the evolution of a dusty protoplanetary disc with two different dust species (1 mm and 50 cm dust grains), under the presence of the instability. We show how toroidal vortices, triggered by the interaction of mm grains with the gas, stop the radial migration of metre-sized dust, potentially offering a natural and efficient solution to the dust migration problem.

  12. Experiments with a fully toroidal Extrap Z-pinch

    International Nuclear Information System (INIS)

    In the Extrap plasma confinement scheme, a Z-pinch is produced along the null of an octupole field generated by currents in external conductors. In the paper, studies of the discharge startup process in a fully toroidal configuration are described. Startup involves first breaking down a toroidal discharge and then driving up the current in order to reach the pinch parameter regime. Current densities of 2x106 A·m-2 have been achieved. The estimated plasma density is 6x1020m-3, and the temperature is about 4 eV. These parameters correspond to pinch conditions. (author)

  13. Low frequency wave propagation in hot toroidal plasma

    International Nuclear Information System (INIS)

    The equation for low frequency wave propagation in full toroidal geometry with arbitrary cross section is derived. It is mainly shown that, when including self consistently the various absorption terms from Vlasov equation in the dielectric tensor, the global wave structure is described by a fourth order system, which even reduces to a second order Helmoltz type equation when neglecting toroidal corrections. Close to the singular ion ion conversion layer, the structure of the wave is strongly affected. Finite Larmor radius conversion effects there compete with simple absorption mechanisms via Landau or cyclotron Landau damping making the FLR effects not likely to dominate nor even occur

  14. Toroidal equilibrium of plasma with concentrated relativistic electron beam

    International Nuclear Information System (INIS)

    A simplified model has been given for toroidal equilibrium of a tokamak-type plasma with high-current concentrated electron beam. The plasma has a thermal pressure, and the electron beam has effective inertial pressure. Strong deformations of tokamak equilibria have been simulated by numerical calculations. Toroidal equilibria with relatively large vertical field are obtained when we consider high-energy intense electron beam. The beam orbit, which is shifted outward from the magnetic axis of the plasma, is closed by the sum of the externally applied relatively large vertical field and the poloidal magnetic field of the plasma. (author)

  15. Development and verification of printed circuit board toroidal transformer model

    DEFF Research Database (Denmark)

    Pejtersen, Jens; Mønster, Jakob Døllner; Knott, Arnold

    2013-01-01

    comparing calculated parameters with 3D finite element simulations and experimental measurement results. The developed transformer model shows good agreement with the simulated and measured results. The model can be used to predict the parameters of printed circuit board toroidal transformer configurations......An analytical model of an air core printed circuit board embedded toroidal transformer configuration is presented. The transformer has been developed for galvanic isolation of very high frequency switch-mode dc-dc power converter applications. The theoretical model is developed and verified by...

  16. Development and verification of printed circuit board toroidal transformer model

    DEFF Research Database (Denmark)

    Pejtersen, Jens; Mønster, Jakob Døllner; Knott, Arnold

    comparing calculated parameters with 3D finite element simulations and experimental measurement results. The developed transformer model shows good agreement with the simulated and measured results. The model can be used to predict the parameters of printed circuit board toroidal transformer configurations......An analytical model of an air core printed circuit board embedded toroidal transformer configuration is presented. The transformer has been developed for galvanic isolation of very high frequency switch-mode dc-dc power converter applications. The theoretical model is developed and verified by...

  17. Comparative study between toroidal coordinates and the magnetic dipole field

    CERN Document Server

    Chávez-Alarcón, Esteban

    2012-01-01

    There is a similar behaviour between the toroidal coordinates and the dipole magnetic field produced by a circular loop. In this work we evaluate up to what extent the former can be used as a representation of the latter. While the tori in the toroidal coordinates have circular cross sections, those of the circular loop magnetic field are nearly elliptical ovoids, but they are very similar for large aspect ratios.The centres of the latter displace from the axis faster than the former. By making a comparison between tori of similar aspect ratios, we find quantitative criteria to evaluate the accuracy of the approximation.

  18. Self-interference of a toroidal Bose–Einstein condensate

    International Nuclear Information System (INIS)

    We demonstrate the self-interference of a single Bose–Einstein condensate on a non-simply connected geometry, focussing on a toroidally trapped ring-shaped condensate. First, we show how the opposite parts of the ring can interfere using the Wigner function representation. Then, using analytical expressions for the time-evolution of a freely expanding ring-shaped condensate with and without a persistent current, we show that the self-interference of the ring-shaped condensate is possible only in the absence of the persistent current. We conclude by proposing an experimental protocol for the creation of ring dark solitons using the toroidal self-interference

  19. Ion temperature gradient modes in toroidal helical systems

    International Nuclear Information System (INIS)

    Linear properties of ion temperature gradient (ITG) modes in helical systems are studied. The real frequency, growth rate, and eigenfunction are obtained for both stable and unstable cases by solving a kinetic integral equation with proper analytic continuation performed in the complex frequency plane. Based on the model magnetic configuration for toroidal helical systems like the Large Helical Device (LHD), dependences of the ITG mode properties on various plasma equilibrium parameters are investigated. Particularly, relative effects of ∇B-curvature drifts driven by the toroidicity and by the helical ripples are examined in order to compare the ITG modes in helical systems with those in tokamaks. (author)

  20. Toroidal Spiral Strings in Higher-dimensional Spacetime

    OpenAIRE

    Igata, Takahisa; Ishihara, Hideki

    2010-01-01

    We report on our progress in research of separability of the Nambu-Goto equation for test strings with a symmetric configuration in a shape of toroidal spiral in a five-dimensional Kerr-AdS black hole. In particular, for a Hopf loop string which is a special class of the toroidal spirals, we show the complete separation of variables occurs in two cases, Kerr background and Kerr-AdS background with equal angular momenta. We also obtain the dynamical solution for the Hopf loop around a black ho...

  1. Reevaluation of the Braginskii viscous force for toroidal plasma

    CERN Document Server

    Johnson, Robert W

    2009-01-01

    The model by Braginskii for the viscous stress tensor is used to determine the shear and gyroviscous forces acting within a toroidally confined plasma. Comparison is made to previous evaluations which contain an inconsistent treatment of the radial derivative and neglect the effect of the pitch angle. A radial gyroviscous force is found to survive the limit of constant density and rigid toroidal rotation of the flux surface, and a radial shear viscous force may develop for sufficient vertical asymmetry to the ion velocity profile.

  2. Induction Motor with Switchable Number of Poles and Toroidal Winding

    Directory of Open Access Journals (Sweden)

    MUNTEANU, A.

    2011-05-01

    Full Text Available This paper presents a study of an induction motor provided with toroidal stator winding. The ring-type coils offer a higher versatility in obtaining a different number of pole pairs by means of delta/star and series/parallel connections respectively. As consequence, the developed torque can vary within large limits and the motor can be utilized for applications that require, for example, high load torque values for a short time. The study involves experimental tests and FEM simulation for an induction machine with three configurations of pole pairs. The conclusions attest the superiority of the toroidal winding for certain applications such as electric vehicles or lifting machines.

  3. Wake-field and space charge effects on high brightness beams calculations and measured results for the laser driven photoelectrons at BNL-ATF

    International Nuclear Information System (INIS)

    We discuss the formalism used to study the effects of the interactions between the highly charged particles and the fields in the accelerating structure, including space charge and wake fields. Some of our calculations and numerical simulation results obtained for the Brookhaven National Laboratory (BNL) high-brightness photoelectron beam at the Accelerator Test Facility (ATF) and the measured data at ATF are also included

  4. Aspergillus nidulans transcription factor AtfA interacts with the MAPK SakA to regulate general stress responses, development and spore functions

    OpenAIRE

    Lara-Rojas, Fernando; Sánchez, Olivia; Kawasaki, Laura; Aguirre, Jesús

    2011-01-01

    Fungi utilize a phosphorelay system coupled to a MAP kinase module for sensing and processing environmental signals. In Aspergillus nidulans, response regulator SskA transmits osmotic and oxidative stress signals to the stress MAPK (SAPK) SakA. Using a genetic approach together with GFP tagging and molecular bifluorescence we show that SakA and ATF/CREB transcription factor AtfA define a general stress-signalling pathway that plays differential roles in oxidative stress responses during growt...

  5. Intervention of electroacupuncture on spinal p38 MAPK/ATF-2/VR-1 pathway in treating inflammatory pain induced by CFA in rats

    OpenAIRE

    Fang, Jian-Qiao; Du, Jun-Ying; Liang, Yi; Fang, Jun-Fan

    2013-01-01

    Background Previous studies have demonstrated that p38 MAPK signal transduction pathway plays an important role in the development and maintenance of inflammatory pain. Electroacupuncture (EA) can suppress the inflammatory pain. However, the relationship between EA effect and p38 MAPK signal transduction pathway in inflammatory pain remains poorly understood. It is our hypothesis that p38 MAPK/ATF-2/VR-1 and/or p38 MAPK/ATF-2/COX-2 signal transduction pathway should be activated by inflammato...

  6. Effects of Toroidal Rotation Shear on Toroidicity-induced Alfven Eigenmodes in the National Spherical Torus Experiment

    International Nuclear Information System (INIS)

    The effects of a sheared toroidal rotation on the dynamics of bursting Toroidicity-induced Alfven eigenmodes are investigated in neutral beam heated plasmas on the National Spherical Torus Experiment (NSTX) (M. Ono et al., Nucl. Fusion 40 557 (2000)). The modes have a global character, extending over most of the minor radius. A toroidal rotation shear layer is measured at the location of maximum drive for the modes. Contrary to results from other devices, no clear evidence of increased damping is found. Instead, experiments with simultaneous neutral beam and radio-frequency auxiliary heating show a strong correlation between the dynamics of the modes and the instability drive. It is argued that kinetic effects involving changes in the mode drive and damping mechanisms other than rotation shear, such as continuum damping, are mostly responsible for the bursting dynamics of the modes.

  7. Effects of Toroidal Rotation Sshear on Toroidicity-induced Alfven Eigenmodes in the National Spherical Torus Experiment

    Energy Technology Data Exchange (ETDEWEB)

    Podesta, M; Fredrickson, E D; Gorelenkov, N N; LeBlanc, B P; Heidbrink, W W; Crocker, N A; Kubota, S

    2010-08-19

    The effects of a sheared toroidal rotation on the dynamics of bursting Toroidicity-induced Alfven eigenmodes are investigated in neutral beam heated plasmas on the National Spherical Torus Experiment (NSTX) [M. Ono et al., Nucl. Fusion 40 557 (2000)]. The modes have a global character, extending over most of the minor radius. A toroidal rotation shear layer is measured at the location of maximum drive for the modes. Contrary to results from other devices, no clear evidence of increased damping is found. Instead, experiments with simultaneous neutral beam and radio-frequency auxiliary heating show a strong correlation between the dynamics of the modes and the instability drive. It is argued that kinetic effects involving changes in the mode drive and damping mechanisms other than rotation shear, such as continuum damping, are mostly responsible for the bursting dynamics of the modes.

  8. Beam oscillation and long-term movement research in KEK-ATF using the digital BPM system 'Libera'

    International Nuclear Information System (INIS)

    We are performing fast and high resolution beam position measurement with a digital BPM system 'Libera' manufactured by Instrumentation Technologies for the purpose of establishing submicron level beam stability needed in cutting-edge accelerators. We performed a beam test at KEK-ATF damping ring to verify performance in ultra low emittance beam position measurement, comparing its results to ones of a bench tests that was performed to verify performance of Libera in stand-alone. Furthermore we researched both beam oscillation and long-term beam movement in KEK-ATF. The results of the performance tests and the measurement of beam oscillation and long-term beam movement are reported in this paper. (author)

  9. ATF3 upregulation in glia during Wallerian degeneration: differential expression in peripheral nerves and CNS white matter

    OpenAIRE

    Coffin Robert S; Mason Matthew RJ; Hossain-Ibrahim Kismet; Hunt David; Lieberman AR; Winterbottom Julia; Anderson PN

    2004-01-01

    Abstract Background Many changes in gene expression occur in distal stumps of injured nerves but the transcriptional control of these events is poorly understood. We have examined the expression of the transcription factors ATF3 and c-Jun by non-neuronal cells during Wallerian degeneration following injury to sciatic nerves, dorsal roots and optic nerves of rats and mice, using immunohistochemistry and in situ hybridization. Results Following sciatic nerve injury – transection or transection ...

  10. Inhibin beta E is upregulated by drug-induced endoplasmic reticulum stress as a transcriptional target gene of ATF4

    International Nuclear Information System (INIS)

    Inhibins and activins are gonadal peptide hormones of the transforming growth factor-β super family with important functions in the reproductive system. By contrast, the recently identified inhibin βE subunit, primarily expressed in liver cells, appears to exert functions unrelated to the reproductive system. Previously shown downregulation of inhibin βE in hepatoma cells and anti-proliferative effects of ectopic inhibin βE overexpression indicated growth-regulatory effects of inhibin βE. We observed a selective re-expression of the inhibin βE subunit in HepG2 hepatoblastoma cells, MCF7 breast cancer cells, and HeLa cervical cancer cells under endoplasmic reticulum stress conditions induced by tunicamycin, thapsigargin, and nelfinavir. Analysis of XPB1 splicing and ATF4 activation revealed that inhibin βE re-expression was associated with induction of the endoplasmic reticulum stress reaction by these drugs. Transfection of an ATF4 expression plasmid specifically induced inhibin βE expression in HeLa cells and indicates inhibin βE as a hitherto unidentified target gene of ATF4, a key transcription factor of the endoplasmic reticulum stress response. Therefore, the inhibin βE subunit defines not only a new player but also a possible new marker for drug-induced endoplasmic reticulum stress. -- Highlights: ► Endoplasmic reticulum stress induces inhibin beta E expression. ► Inhibin beta E is regulated by the transcription factor ATF4. ► Inhibin beta E expression can be used as a marker for drug-induced ER stress.

  11. The Yeast ATF1 Acetyltransferase Efficiently Acetylates Insect Pheromone Alcohols: Implications for the Biological Production of Moth Pheromones.

    Science.gov (United States)

    Ding, Bao-Jian; Lager, Ida; Bansal, Sunil; Durrett, Timothy P; Stymne, Sten; Löfstedt, Christer

    2016-04-01

    Many moth pheromones are composed of mixtures of acetates of long-chain (≥10 carbon) fatty alcohols. Moth pheromone precursors such as fatty acids and fatty alcohols can be produced in yeast by the heterologous expression of genes involved in insect pheromone production. Acetyltransferases that subsequently catalyze the formation of acetates by transfer of the acetate unit from acetyl-CoA to a fatty alcohol have been postulated in pheromone biosynthesis. However, so far no fatty alcohol acetyltransferases responsible for the production of straight chain alkyl acetate pheromone components in insects have been identified. In search for a non-insect acetyltransferase alternative, we expressed a plant-derived diacylglycerol acetyltransferase (EaDAcT) (EC 2.3.1.20) cloned from the seed of the burning bush (Euonymus alatus) in a yeast system. EaDAcT transformed various fatty alcohol insect pheromone precursors into acetates but we also found high background acetylation activities. Only one enzyme in yeast was shown to be responsible for the majority of that background activity, the acetyltransferase ATF1 (EC 2.3.1.84). We further investigated the usefulness of ATF1 for the conversion of moth pheromone alcohols into acetates in comparison with Ea DAcT. Overexpression of ATF1 revealed that it was capable of acetylating these fatty alcohols with chain lengths from 10 to 18 carbons with up to 27- and 10-fold higher in vivo and in vitro efficiency, respectively, compared to Ea DAcT. The ATF1 enzyme thus has the potential to serve as the missing enzyme in the reconstruction of the biosynthetic pathway of insect acetate pheromones from precursor fatty acids in yeast. PMID:26801935

  12. Inhibin beta E is upregulated by drug-induced endoplasmic reticulum stress as a transcriptional target gene of ATF4

    Energy Technology Data Exchange (ETDEWEB)

    Brüning, Ansgar, E-mail: ansgar.bruening@med.uni-muenchen.de; Matsingou, Christina; Brem, German Johannes; Rahmeh, Martina; Mylonas, Ioannis

    2012-10-15

    Inhibins and activins are gonadal peptide hormones of the transforming growth factor-β super family with important functions in the reproductive system. By contrast, the recently identified inhibin βE subunit, primarily expressed in liver cells, appears to exert functions unrelated to the reproductive system. Previously shown downregulation of inhibin βE in hepatoma cells and anti-proliferative effects of ectopic inhibin βE overexpression indicated growth-regulatory effects of inhibin βE. We observed a selective re-expression of the inhibin βE subunit in HepG2 hepatoblastoma cells, MCF7 breast cancer cells, and HeLa cervical cancer cells under endoplasmic reticulum stress conditions induced by tunicamycin, thapsigargin, and nelfinavir. Analysis of XPB1 splicing and ATF4 activation revealed that inhibin βE re-expression was associated with induction of the endoplasmic reticulum stress reaction by these drugs. Transfection of an ATF4 expression plasmid specifically induced inhibin βE expression in HeLa cells and indicates inhibin βE as a hitherto unidentified target gene of ATF4, a key transcription factor of the endoplasmic reticulum stress response. Therefore, the inhibin βE subunit defines not only a new player but also a possible new marker for drug-induced endoplasmic reticulum stress. -- Highlights: ► Endoplasmic reticulum stress induces inhibin beta E expression. ► Inhibin beta E is regulated by the transcription factor ATF4. ► Inhibin beta E expression can be used as a marker for drug-induced ER stress.

  13. Letter Report Documenting Progress of Second Generation ATF FeCrAl Alloy Fabrication

    Energy Technology Data Exchange (ETDEWEB)

    Yamamoto, Y. [ORNL; Yang, Y. [ORNL; Field, K. G. [ORNL; Terrani, K. [ORNL; Pint, B. A. [ORNL; Snead, L. L. [ORNL

    2014-06-10

    Development of the 2nd generation ATF FeCrAl alloy has been initiated, and a candidate alloy was selected for trial tube fabrication through hot-extrusion and gun-drilling processes. Four alloys based on Fe-13Cr-4.5Al-0.15Y in weight percent were newly cast with minor alloying additions of Mo, Si, Nb, and C to promote solid-solution and second-phase precipitate strengthening. The alloy compositions were selected with guidance from computational thermodynamic tools. The lab-scale heats of ~ 600g were arc-melted and drop-cast, homogenized, hot-forged and -rolled, and then annealed producing plate shape samples. An alloy with Mo and Nb additions (C35MN) processed at 800°C exhibits very fine sub-grain structure with the sub-grain size of 1-3μm which exhibited more than 25% better yield and tensile strengths together with decent ductility compared to the other FeCrAl alloys at room temperature. It was found that the Nb addition was key to improving thermal stability of the fine sub-grain structure. Optimally, grains of less than 30 microns are desired, with grains up to and order of magnitude in desired produced through Nb addition. Scale-up effort of the C35MN alloy was made in collaboration with a commercial cast company who has a capability of vacuum induction melting. A 39lb columnar ingot with ~81mm diameter and ~305mm height (with hot-top) was commercially cast, homogenized, hot-extruded, and annealed providing 10mm-diameter bar-shape samples with the fine sub-grain structure. This commercial heat proved consistent with materials produced at ORNL at the lab-scale. Tubes and end caps were machined from the bar sample and provided to another work package for the ATF-1 irradiation campaign in the milestone M3FT-14OR0202251.

  14. Beam-Based Alignment, Tuning and Beam Dynamics Studies for the ATF2 Extraction Line and Final Focus System

    International Nuclear Information System (INIS)

    Using a new extraction line currently under construction, the ATF2 experiment plans to test the novel compact final focus optics design with local chromaticity correction intended for use in future linear colliders. With a 1.3 GeV design beam of 30nm normalized vertical emittance extracted from the ATF damping ring, the primary goal is to achieve a vertical spot-size at the IP waist of 37nm. We discuss our planned strategy for tuning the ATF2 beam to meet the primary goal. Simulation studies have been performed to asses the effectiveness of the strategy, including 'static' (installation) errors and dynamical effects (ground-motion, mechanical vibration, ring extraction jitter etc.). We have simulated all steps in the tuning procedure, from initial orbit establishment to final IP spot-size tuning. Through a Monte Carlo study of 100's of simulation seeds we find we can achieve a spot-size within ∼10% of the design optics value in at least 75% of cases. We also ran a simulation to study the long-term performance with the use of beam-based feedbacks

  15. Mmu-miR-702 functions as an anti-apoptotic mirtron by mediating ATF6 inhibition in mice.

    Science.gov (United States)

    Zhang, Wei-Guang; Chen, Lin; Dong, Qin; He, Juan; Zhao, Han-Dong; Li, Feng-Lan; Li, Hui

    2013-12-01

    MicroRNAs (miRNAs) are a group of endogenous, small, noncoding RNAs that function as key post-transcriptional regulators. miRNAs are involved in many biological processes including apoptosis. In this study, mouse miR-702 (mmu-miR-702), a mirtron derived from the 13th intron of the Plod3 gene, was identified as a regulator of anti-apoptosis. mmu-miR-702 was down-regulated after treatment with the apoptosis-inducer isoproterenol both in vivo and in vitro. According to over-expression experiments, mmu-miR-702 inhibited apoptosis as well as the expression levels of a subset of apoptosis-related genes including activating transcription factor 6 (ATF6). An interaction between mmu-miR-702 and the ATF6 3'-UTR binding site was confirmed using luciferase reporter and western blot assays. This is the first report of ATF6 interaction with miRNA. Although the possible existence of miR-702 in the human genome is low, our results indicate that mirtrons also participate in the process of apoptosis and may provide a novel study strategy for apoptosis. PMID:24035931

  16. The Superconducting Toroid for the New International AXion Observatory (IAXO)

    CERN Document Server

    Shilon, I; Silva, H; Wagner, U; Kate, H H J ten

    2013-01-01

    IAXO, the new International AXion Observatory, will feature the most ambitious detector for solar axions to date. Axions are hypothetical particles which were postulated to solve one of the puzzles arising in the standard model of particle physics, namely the strong CP (Charge conjugation and Parity) problem. This detector aims at achieving a sensitivity to the coupling between axions and photons of one order of magnitude beyond the limits of the current detector, the CERN Axion Solar Telescope (CAST). The IAXO detector relies on a high-magnetic field distributed over a very large volume to convert solar axions to detectable X-ray photons. Inspired by the ATLAS barrel and end-cap toroids, a large superconducting toroid is being designed. The toroid comprises eight, one meter wide and twenty one meters long racetrack coils. The assembled toroid is sized 5.2 m in diameter and 25 m in length and its mass is about 250 tons. The useful field in the bores is 2.5 T while the peak magnetic field in the windings is 5....

  17. Compact-Toroid development: status and technical needs

    International Nuclear Information System (INIS)

    This document contains the description, goals, status, plans, and strategy for the technical development of a class of magnetic confinement configurations collectively identified as Compact Toroids. This component of the magnetic fusion development program has been characterized by its potential for physical compactness and range of output power

  18. Theory of the M = 1 Kink Mode in Toroidal Plasma

    NARCIS (Netherlands)

    de Blank, H. J.; Schep, T. J.

    1991-01-01

    The energy principle of ideal magnetohydrodynamics (MHD) is used to study the ideal MHD stability of the m = 1 internal kink mode in a toroidal plasma. The equilibrium configurations that are considered allow for a broad region where the safety factor q is close to unity. This region may extend to t

  19. A toroidal inductor integrated in a standard CMOS process

    DEFF Research Database (Denmark)

    Vandi, Luca; Andreani, Pietro; Temporiti, Enrico;

    2007-01-01

    This paper presents a toroidal inductor integrated in a standard 0.13 um CMOS process. Finite-elements preliminary simulations are provided to prove the validity of the concept. In order to extract fundamental parameters by means of direct calculations, two different and well-known approaches...

  20. First studies of plasma confined in a toroidal heliac

    International Nuclear Information System (INIS)

    The first experimental results obtained on plasma confined in a toroidal heliac are reported. A simple method of generating highly ionized, weakly collisional plasma is described. It is found that the geometry of the plasma in general and the measured pressure profiles in particular conform closely with the calculated helical axis magnetic surfaces. Preliminary indications of plasma confinement are favourable

  1. Plasma Heating and Losses in Toroidal Multipole Fields

    International Nuclear Information System (INIS)

    The heating and loss of plasmas have been studied in three pulsed, toroidal multipole devices: a large levitated octupole, a small supported octupole and a very small supported quadrupole. Plasmas are produced by gun injection and heated by electron and ion cyclotron resonance heating and ohmic heating. Electron cyclotron heating rates have been measured over a wide range of parameters, and the results are in quantitative agreement with stochastic heating theory. Electron cyclotron resonance heating produces ions with energies larger than predicted by theory. With the addition of a toroidal field, ohmic heating gives densities as high as 1013cm-3 in the toroidal quadrupole and 1012cm-3 in the small octupole. Plasma losses for n=5 x 109cm-3 plasmas are inferred from Langmuir probe and Fabry-Perot interferometer measurements, and measured with special striped collectors on the wall and rings. The loss to a levitated ring is measured using a modulated light beam telemeter. The confinement is better than Bohm but considerably worse than classical. Low frequency convective cells which are fixed in space are observed. These cells around the ring are diminished when a weak toroidal field is added, and loss collectors show a vastly reduced flux to the rings. Analysis of the spatial density profile shows features of B-independent diffusion. The confinement is sensitive to some kinds of dc field errors, but surprisingly insensitive to perturbations of the ac confining field

  2. ATLAS-Lowering the first Barrel Toroid coil

    CERN Multimedia

    CERN Audiovisual Unit

    2004-01-01

    Cranes lowered the first of ATLAS's eight Barrel Toroid coils into the cavern. The part is 25 metres long and the cranes had to hold the 100 tonne coil at a sharp angle while it passed through the 18-metre diameter vertical shaft into the cavern. Then they laid the magnet to a horisontal robust platform. Images from Camera 1

  3. ATLAS-Lowering the first Barrel Toroid coil

    CERN Multimedia

    CERN Audiovisual Unit

    2004-01-01

    Cranes lowered the first of ATLAS's eight Barrel Toroid coils into the cavern. The part is 25 meters long and the cranes had to hold the 100 tonne coil at a sharp angle while it passed through the 18-meter diameter vertical shaft into the cavern. Then they laid the magnet to a horizontal robust platform. Images from Camera 2

  4. Plasma Processes : Minimum dissipative relaxed states in toroidal plasmas

    Indian Academy of Sciences (India)

    R Bhattacharyya; M S Janaki; B Dasgupta

    2000-11-01

    Relaxation of toroidal discharges is described by the principle of minimum energy dissipation together with the constraint of conserved global helicity. The resulting Euler-Lagrange equation is solved in toroidal coordinates for an axisymmetric torus by expressing the solutions in terms of Chandrasekhar-Kendall (C-K) eigenfunctions analytically continued in the complex domain. The C-K eigenfunctions are obtained as hypergeometric functions that are solutions of scalar Helmholtz equation in toroidal coordinates in the large aspect-ratio approximation. Equilibria are constructed by assuming the current to vanish at the edge of plasma. For the = 0; = 0 ( and are the poloidal and toroidal mode numbers respectively) relaxed states, the magnetic field, current, (safety factor) and pressure profiles are calculated for a given value of aspect-ratio of the torus and for different values of the eigenvalue 0. The new feature of the present model is that solutions allow for both tokamak as well as RFP-like behaviour with increase in the values of 0, which is related directly to volt-sec in the experiment.

  5. First ATLAS Barrel Toroid coil casing arrives at CERN

    CERN Document Server

    2002-01-01

    The first of eight 25-metre long coil casings for the ATLAS experiment's barrel toroid magnet system arrived at CERN on Saturday 2 March by road from Heidelberg. This structure will be part of the largest superconducting toroid magnet ever made.   The first coil casing for the toroidal magnets of Atlas arrives at Building 180. This is the start of an enormous three-dimensional jigsaw puzzle. Each of the eight sets of double pancake coils will be housed inside aluminium coil casings, which in turn will be held inside a stainless steel vacuum vessel. A huge construction, the casing that arrived at CERN measures 25 metres in length and 5 metres in width. It weighs 20 tones. And this is just the beginning of the toroid jigsaw: by early April a batch of four double pancake coils, which altogether weighs 65 tones, will arrive from Ansaldo in Italy. The first vacuum vessel will also be arriving from Felguera in Spain this month. It will take about two years for all these 25 m long structures of casings, coils a...

  6. An Overview of Plasma Confinement in Toroidal Systems

    OpenAIRE

    Dini, Fatemeh; Baghdadi, Reza; Amrollahi, Reza; Khorasani, Sina

    2009-01-01

    This overview presents a tutorial introduction to the theory of magnetic plasma confinement in toroidal confinement systems with particular emphasis on axisymmetric equilibrium geometries, and tokamaks. The discussion covers three important aspects of plasma physics: Equilibrium, Stability, and Transport. The section on equilibrium will go through an introduction to ideal magnetohydrodynamics, curvilinear system of coordinates, flux coordinates, extensions to axisymmetric equilibrium, Grad-Sh...

  7. Stationary magnetohydrodynamic equilibrium of toroidal plasma in rotation

    International Nuclear Information System (INIS)

    The stationary equations of classical magnetohydrodynamics are utilized to study the toroidal motion of a thermonuclear magnetically - confined plasma with toroidal symmetry (Tokamak). In the present work, we considered a purely toroidal stationary rotation and te problem is reduced to studing a second order partial differencial equation of eliptic type Maschke-Perrin. Assuming that the temperature remains constant on the magnetic surfaces, an analitic solution, valid for low Mach numbers (M ≤ 0 .4), was obtained for the above-mentioned equation by means of a technique developed by Pantuso Sudano. From the solution found, we traced graphs for the quantities which described the equilibrium state of the plasma, namely: mass density, pressure, temperature, electric current density and toroidal magnetic field. Finally we compare this analitical model with others works which utilized differents analitical models and numerical simulations. We conclude that the solutions obtained are in good agreement with the previos results. In addition, however, our model contains the results of Sudano-Goes with the additional advantage of employing much simple analitical expressions. (author)

  8. Evidence of Inward Toroidal Momentum Convection in the JET Tokamak

    DEFF Research Database (Denmark)

    Tala, T.; Zastrow, K.-D.; Ferreira, J.;

    2009-01-01

    Experiments have been carried out on the Joint European Torus tokamak to determine the diffusive and convective momentum transport. Torque, injected by neutral beams, was modulated to create a periodic perturbation in the toroidal rotation velocity. Novel transport analysis shows the magnitude an...

  9. Theoretical studies of non inductive current drive in compact toroids

    NARCIS (Netherlands)

    Farengo, R; Lifschitz, AF; Caputi, KI; Arista, NR; Clemente, RA

    2002-01-01

    Three non inductive current drive methods that can be applied to compact toroids axe studied. The use of neutral beams to drive current in field reversed configurations and spheromaks is studied using a Monte Carlo code that includes a complete ionization package and follows the exact particle orbit

  10. Barrel Toroid fully charged to nominal field, and it works!

    CERN Multimedia

    Herman ten Kate

    After a few weeks of testing up to intermediate currents, finally, on Thursday evening November 9, the current in the Barrel Toroid was pushed up to its nominal value of 20500 A and even 500 A beyond this value to prove that we have some margin. It went surprisingly well. Of course, the 8 coils forming the toroid were already tested individually at the surface but still, some surprise may have come from those parts added to the toroid in the cavern for the first time like the 8 cryoring sections linking the coils as well as the valve box at the bottom in sector 13 regulating the helium flow or the current lead cryostat on the top in sector 5. No training quenches, nothing to worry about, and the test was concluded with a fast dump triggered at 00:40 in the very early morning of November 10. (left) The toroid current during the evening and night of November 9. (right) The test crew oscillated between fear and hope while looking at the control panels as the current approached 21kA. Big relief was in the...

  11. Stability of toroidal magnetic fields in stellar interiors

    CERN Document Server

    Ibañez-Mejia, Juan C

    2015-01-01

    We present 3D MHD simulations of purely toroidal and mixed poloidal-toroidal magnetic field configurations to study the behavior of the Tayler instability. For the first time the simultaneous action of rotation and magnetic diffusion are taken into account and the effects of a poloidal field on the dynamic evolution of unstable toroidal magnetic fields is included. In the absence of diffusion, fast rotation (rotation rate compared to Alfv\\'en frequency) is able to suppress the instability when the rotation and magnetic axes are aligned and when the radial field strength gradient p 1.5, rapid rotation does not suppress the instability but instead introduces a damping factor to the growth rate in agreement with the analytic predictions. For the mixed poloidal-toroidal fields we find an unstable axisymmetric mode, not predicted analytically, right at the stability threshold for the non-axisymmetric modes; it has been argued that an axisymmetric mode is necessary for the closure of the Tayler-Spruit dynamo loop.

  12. The Quasi-Toroidal Stellarator: An Innovative Confinement Experiment

    International Nuclear Information System (INIS)

    To develop a new class of stellarators that exhibit improved confinement compared to conventional stellarators. This approach generally makes use of a designed symmetry of the magnetic field strength along a particular coordinate axis in the toroidal geometry of the stellarator, and is referred to as quasi-symmetry

  13. Toroidal and poloidal momentum transport studies in JET

    DEFF Research Database (Denmark)

    Tala, T.; Andrew, Y.; Crombe, K.;

    2007-01-01

    This paper reports on the recent studies of toroidal and poloidal momentum transport in JET. The ratio of the global energy confinement time to the momentum confinement is found to be close to tau(E)/tau(phi) = 1 except for the low density or low collisionality discharges where the ratio is tau(E...

  14. Toroidal solenoids in the electromagnetic field and Aharonov-Casher effect

    International Nuclear Information System (INIS)

    The current toroidal configurations are found which generate gauge nonequivalent vector potentials and correspond to the same quantum scattering of charged particles. The equations for the motion of toroidal moment in the magnetic field are obtained. It is proved the existence of Aharonov-Casher effect for the toroidal solenoids. The relating experiments are proposed. 19 refs.; 7 figs

  15. Homogeneous Construction of the Toroidal Lie Algebra of Type A1

    Institute of Scientific and Technical Information of China (English)

    Haifeng Lian; Cui Chen; Qinzhu Wen

    2007-01-01

    In this paper,we consider an analogue of the level two homogeneous construc-tion of the affine Kac-Moody algebra A1(1) by vertex operators.We construct modules for the toroidal Lie algebra and the extended toroidal Lie algebra of type A1.We also prove that the module is completely reducible for the extended toroidal Lie algebra.

  16. Results of the variable toroidal field ripple experiments in JET

    International Nuclear Information System (INIS)

    The main goal of ITER is to produce plasmas with high fusion gain (QDT > 10), where a large fraction of the plasma heating is supplied by the α-particles from fusion reactions. To first order, this requires both thermal and fast ion confinement to be at least as good as predictions. In all tokamak devices, the finite number and toroidal extension of the toroidal field (TF) coils causes a periodic variation of the toroidal field from its nominal value, called toroidal field ripple δBT = (Bmax - Bmin)/Bav. It is well known that ripple in the toroidal field adversely affects fast ion confinement, and in the case of ITER, this has been accounted for by including in the design Ferritic Insets (FI) compensation, reducing δBT from approx 1.2% to approx 0.5%, to reduce first wall power loads. In these conditions, the main α-particle loss mechanism in ITER will be ripple banana orbit diffusion, and that the magnitude of these losses is expected to be in the 1% region, therefore negligible in terms of alpha-particle confinement. Experimental results from JT60-U and H-mode dimensionless H-mode experiments in JET and JT-60U have indicated that ripple may also affect the H-mode confinement, pedestal height, ELM size and plasma rotation. Although the physics mechanisms at the root of the reduced energy confinement with δBT was not identified unambiguously, the implication of a reduction of energy confinement on projected ITER performance due to ripple stimulated a series of experiments at JET. The experiments were carried out in the ELMy H-mode regime with q95 = 3, and investigated the effect of δBT on the pedestal and core properties of the plasma. Plasma density pump out and reduction of the global energy confinement was found for δBT around 0.5, in some experimental conditions. Ripple was also found to affect the size and frequency of ELMs. Plasma toroidal rotation was also strongly affected by ripple: the toroidal velocity is reduced for increased ripple and becomes

  17. Analysis of Performance of Selected AFC, ATF Fuels, and Lanthanide Transport

    Energy Technology Data Exchange (ETDEWEB)

    Unal, Cetin [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Galloway, Jack D. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2015-09-29

    We started to look at the performance of ATF concept in LWRs late in FY14 and finish our studies in FY15. The work has been presented in AFC review meetings, ICAPP and TOPFUEL conferences. The final version of the work is accepted for publication in Nuclear Engineering and Science Journal (NES). The copy of ICAPP and NES papers are attached separately to this document as our milestone deliverables. We made an important progress in the modeling of lanthanide transport in FY15. This work produced an ANS Winter Meeting paper and GLOBAL 2015 paper. GLOBAL 2015 paper is also attached as deliverable of FY15. The work on the lanthanide transport is preliminary. We are exploring other potential mechanisms, in addition to “liquid-like” diffusion mechanisms, proposed by Robert Mariani [1] before we analyze data that will be taken by Ohio State University. This year, we concentrate on developing diffusion kernels and principles of modeling. Next year, this work will continue and analyze the Ohio State data and develop approaches to solve multicomponent diffusion. In addition to three papers we attached to this report, we have done some research on coupling and the development of gas release model for metallic fuels in FY15. They are also preliminary in nature; therefore, we give the summary of what we found rather than an extended report that will be done in FY16.

  18. Design parameters of the high gain harmonic generation experiment using Cornell undulator A at the ATF

    International Nuclear Information System (INIS)

    The authors present the design parameters of a high gain harmonic generation (HGHG) FEL experiment to be carried out at the accelerator test facility (ATF) at BNL, in collaboration with APS. This experiment is a proof-of-principle experiment for the DUV-FEL at BNL. In the HGHG experiment they plan to double the frequency of a CO2 seed laser by utilizing a 0.76 m long 9 period undulator (named the Mini Undulator), a 2 m long 60 period undulator (named the Cornell Undulator A), and a 0.3 m electromagnet chicane (the dispersive section). The first undulator will be used in conjunction with the CO2 seed laser to generate a ponderomotive force that will bunch the electron beam. The bunching will then be enhanced by the dispersion section. The second undulator, the Cornell Undulator A, tuned to the second harmonic of the seed laser will serve as the radiator. In the beginning of the radiator the bunched beam will produce coherent emission (characterized by a quadratic growth of the radiated power), then the radiation will be amplified exponentially. They plan to study the evolution of the various radiation growth mechanisms as well as the coherence of the doubled, exponentially amplified radiation

  19. Microfabrication of toroidal inductors integrated with nanolaminated ferromagnetic metallic cores

    International Nuclear Information System (INIS)

    We report microfabricated toroidal inductors with nanolaminated ferromagnetic metallic cores for chip-scale, high-power switching converters. The fabrication process of the toroidal inductor is based on individual manufacturing of partial windings (i.e. bottom and vertical conductors) and nanolaminated magnetic core, and integrating them by means of a drop-in approach. The nanolaminated ferromagnetic metallic cores presented in this paper consist of many multilayers of electrodeposited CoNiFe films, each layer with sub-micron thickness, with a total core thickness exceeding tens of microns. The beneficial magnetic properties (i.e. high saturation flux density and low coercivity) of CoNiFe alloys are well suited for chip-scale inductors as they achieve both large energy storage capacity as well as minimized volumetric core losses at high operating frequencies due to their nanolaminated structure. A drop-in integration approach, introduced to combine the microfabricated toroidal inductor windings with the magnetic cores, allows ease of integration. An advantage of this hybrid approach over monolithic fabrication in this application is the potential use of a wide variety of core materials, both microfabricated and bulk-fabricated, and which may or may not ultimately be CMOS-compatible. Exploiting this drop-in approach, 30-turn- and 50-turn-toroidal inductors integrated with nanolaminated CoNiFe cores, having 10 mm outer diameter and 1 mm thickness, have been successfully developed. Both types of inductors exhibit inductances higher than 1 µH at frequencies up to tens of MHz, showing ten times the inductance of an air core device with the same nominal geometry. The peak quality factor of the 30-turn-toroidal inductor reaches 18 at 1 MHz. (paper)

  20. Dynamical conservation of invariants by toroidal trajectories of guiding centres

    International Nuclear Information System (INIS)

    The classical problem of calculating toroidal trajectories is treated here by comparing the results of two different methods in a given magnetic configuration, a standard divergence-free magnetic field model. The present work consists of adapting the analytical criteria of MERCIER et al. for classical toroidal trajectories, and to examine numerically the dynamical conservation of the toroidal invariant. The first method is based on the evolution equations for the guiding centres. These equations are then solved numerically (code TRATORIA) and the trajectories are drawn for different initial conditions. We use a modified standard model for the magnetic field, which insures a manifestly divergence-free field. Moreover we take into account the contribution of the poloidal field to the total strength of the magnetic field. These corrections contribute to the analytical expression of the conserved toroidal momentum. The latter is verified to be conserved by the present numerical simulation with a precision generally of the order of 10-14. The second method is based on the analytical treatment of the invariants to yield a semi-analytical (semi graphical) determination of the intersection point of a given trajectory with the equatorial plane. Both methods allows one to recover well-known toroidal trajectories with passing and trapped particles (bananas). The present analysis brings a clear description of some other, less well-known types of trajectories, namely the stagnation orbits, the smallest D-shape banana, some small circulating de-flated bananas, some huge classical bananas (potatoes), and the largest puffed bananas which exhibit only local mirroring, along with several kind of escaping or open trajectories which are of importance for fast ion losses and target damages in the machines

  1. Metformin-induced inhibition of the mitochondrial respiratory chain increases FGF21 expression via ATF4 activation

    International Nuclear Information System (INIS)

    Highlights: •Metformin induces FGF21 expression in an AMPK independent manner. •Metformin enhances FGF21 expression by inhibiting mitochondrial complex I activity. •The PERK-eIF2α-ATF4 axis is required for metformin-induced FGF21 expression. •Metformin activates the ATF4-FGF21 axis in the liver of mouse. •Metformin increases serum FGF21 level in diabetic human subjects. -- Abstract: Fibroblast growth factor 21 (FGF21) is an endocrine hormone that exhibits anti-obesity and anti-diabetes effects. Because metformin is widely used as a glucose-lowering agent in patients with type 2 diabetes (T2D), we investigated whether metformin modulates FGF21 expression in cell lines, and in mice or human subjects. We found that metformin increased the expression and release of FGF21 in a diverse set of cell types, including rat hepatoma FaO, primary mouse hepatocytes, and mouse embryonic fibroblasts (MEFs). Intriguingly, AMP-activated protein kinase (AMPK) was dispensable for the induction of FGF21 by metformin. Mammalian target of rapamycin complex 1 (mTORC1) and peroxisome proliferator-activated receptor α (PPARα), which are additional targets of metformin, were not involved in metformin-induced FGF21 expression. Importantly, inhibition of mitochondrial complex I activity by metformin resulted in FGF21 induction through PKR-like ER kinase (PERK)-eukaryotic translation factor 2α (eIF2α)-activating transcription factor 4 (ATF4). We showed that metformin activated ATF4 and increased FGF21 expression in the livers of mice, which led to increased serum levels of FGF21. We also found that serum FGF21 level was increased in human subjects with T2D after metformin therapy for 6 months. In conclusion, our results indicate that metformin induced expression of FGF21 through an ATF4-dependent mechanism by inhibiting mitochondrial respiration independently of AMPK. Therefore, FGF21 induction by metformin might explain a portion of the beneficial metabolic effects of metformin

  2. Metformin-induced inhibition of the mitochondrial respiratory chain increases FGF21 expression via ATF4 activation

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Kook Hwan [Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon-dong Gangnam-gu, Seoul 135-710 (Korea, Republic of); Samsung Advanced Institute for Health Sciences and Technology, Sungkyunkwan University School of Medicine, 50 Irwon-dong Gangnam-gu, Seoul 135-710 (Korea, Republic of); Jeong, Yeon Taek [Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon-dong Gangnam-gu, Seoul 135-710 (Korea, Republic of); Kim, Seong Hun [Samsung Advanced Institute for Health Sciences and Technology, Sungkyunkwan University School of Medicine, 50 Irwon-dong Gangnam-gu, Seoul 135-710 (Korea, Republic of); Jung, Hye Seung; Park, Kyong Soo [Department of Internal Medicine, Seoul National University College of Medicine, 28 Yongon-dong Chongno-gu, Seoul 110-744 (Korea, Republic of); Lee, Hae-Youn [Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon-dong Gangnam-gu, Seoul 135-710 (Korea, Republic of); Lee, Myung-Shik, E-mail: mslee0923@skku.edu [Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon-dong Gangnam-gu, Seoul 135-710 (Korea, Republic of); Samsung Advanced Institute for Health Sciences and Technology, Sungkyunkwan University School of Medicine, 50 Irwon-dong Gangnam-gu, Seoul 135-710 (Korea, Republic of)

    2013-10-11

    Highlights: •Metformin induces FGF21 expression in an AMPK independent manner. •Metformin enhances FGF21 expression by inhibiting mitochondrial complex I activity. •The PERK-eIF2α-ATF4 axis is required for metformin-induced FGF21 expression. •Metformin activates the ATF4-FGF21 axis in the liver of mouse. •Metformin increases serum FGF21 level in diabetic human subjects. -- Abstract: Fibroblast growth factor 21 (FGF21) is an endocrine hormone that exhibits anti-obesity and anti-diabetes effects. Because metformin is widely used as a glucose-lowering agent in patients with type 2 diabetes (T2D), we investigated whether metformin modulates FGF21 expression in cell lines, and in mice or human subjects. We found that metformin increased the expression and release of FGF21 in a diverse set of cell types, including rat hepatoma FaO, primary mouse hepatocytes, and mouse embryonic fibroblasts (MEFs). Intriguingly, AMP-activated protein kinase (AMPK) was dispensable for the induction of FGF21 by metformin. Mammalian target of rapamycin complex 1 (mTORC1) and peroxisome proliferator-activated receptor α (PPARα), which are additional targets of metformin, were not involved in metformin-induced FGF21 expression. Importantly, inhibition of mitochondrial complex I activity by metformin resulted in FGF21 induction through PKR-like ER kinase (PERK)-eukaryotic translation factor 2α (eIF2α)-activating transcription factor 4 (ATF4). We showed that metformin activated ATF4 and increased FGF21 expression in the livers of mice, which led to increased serum levels of FGF21. We also found that serum FGF21 level was increased in human subjects with T2D after metformin therapy for 6 months. In conclusion, our results indicate that metformin induced expression of FGF21 through an ATF4-dependent mechanism by inhibiting mitochondrial respiration independently of AMPK. Therefore, FGF21 induction by metformin might explain a portion of the beneficial metabolic effects of metformin.

  3. Expression and purification of recombinant ATF-mellitin, a new type fusion protein targeting ovarian cancer cells, in P. pastoris.

    Science.gov (United States)

    Su, Manman; Chang, Weiqin; Zhang, Kun; Cui, Manhua; Wu, Shuying; Xu, Tianmin

    2016-02-01

    Melittin is well known to possess cytolytic activity with wide-spectrum lytic properties and its potential use as an agent to treat several types of cancer has been tested. Due to the non-specific toxicity, melittin can impair not only cancer cells but also normal tissue. Thus, tumor-targeted toxins may be helpful for developing novel anticancer therapeutics. The urokinase-type plasminogen activator (uPA) plays a central role in tissue remodelling events occurring in normal physiology and in pathophysiology, including cancer invasion and metastasis. Heartening findings showed that uPA receptor is predominantly expressed on many types of cancer. Therefore, the amino-terminal fragment (ATF) of uPA which was able to identify and bond with cancer cells was used as the cell-targeting domain to make up tumor-targeted toxin in this study. In the present study, pPICZαC-ATF-melittin eukaryotic expression vector was successfully constructed. After transformed into P. pastoris and induced by methanol, rATF-mellitin was detected by SDS-PAGE and western blot analysis. After induction with methanol, the expression level of rATF-mellitin was 312 mg/l in 80-l fermentor. rATF‑mellitin was purified to >95% purity using SP Sepharose ion exchange chromatography and source™ 30 RPC with 67.2% recovery. Cell proliferation assay showed that rATF-melittin inhibited growth of SKOV3 cells and had no cytotoxicity effect on normal cells. For the first time, we established a stable and effective rATF-mellitin P. pastoris expression system to obtain a high level of expression of secreted rATF-mellitin which was purified by a highly efficient purification procedure. PMID:26718643

  4. Estimation of plasma position from tangentially viewed images on a toroidally symmetric device

    International Nuclear Information System (INIS)

    Images of plasma from a fast-framing camera are the most intuitive and reliable data to understand the status of tokamak plasmas. Generation, movement, size variation, and disruptions of plasmas can be clearly observed from these images. However, it is not a simple task to obtain the exact positions and sizes of plasmas using these images because measured two-dimensional images inevitably lose the three-dimensional position information of their targets. In this paper, the exact positions and sizes of plasmas have been calculated from tangentially viewed images using the toroidal symmetry of the plasma in the Korea Superconducting Tokamak Advanced Research (KSTAR) device. The positions and sizes of the plasmas have been manually determined with displayed cursors on images and automatically determined using a correlation factor with calculated virtual plasma images as well. These two results correspond well with each other. The estimated positions have also been compared with those obtained from magnetic diagnostics analysis.

  5. Prospects for searching axion-like particle dark matter with dipole, toroidal and wiggler magnets

    Energy Technology Data Exchange (ETDEWEB)

    Baker, Oliver K. [Yale Univ., New Haven, CT (United States). Dept. of Physics; Betz, Michael; Caspers, Fritz [European Organization for Nuclear Research (CERN), Geneva (Switzerland); Jaeckel, Joerg [Institute for Particle Physics Phenomenology, Durham (United Kingdom); Lindner, Axel; Ringwald, Andreas [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany); Semertzidis, Yannis [Brookhaven National Lab., Upton, NY (United States); Sikivie, Pierre [Florida Univ., Gainesville, FL (United States). Dept. of Physics; Zioutas, Konstantin [Patras Univ. (Greece)

    2011-10-15

    In this work we consider searches for dark matter made of axions or axion-like particles (ALPs) using resonant radio frequency cavities inserted into dipole magnets from particle accelerators, wiggler magnets developed for accelerator based advanced light sources, and toroidal magnets similar to those used in particle physics detectors. We investigate the expected sensitivity of such ALP dark matter detectors and discuss the engineering aspects of building and tuning them. Brief mention is also made of even stronger field magnets that are becoming available due to improvements in magnetic technology. It is concluded that new experiments utilizing already existing magnets could greatly enlarge the mass region in searches for axion-like dark matter particles. (orig.)

  6. Prospects for searching axionlike particle dark matter with dipole, toroidal, and wiggler magnets

    CERN Document Server

    Baker, Oliver K; Caspers, Fritz; Jaeckel, Joerg; Lindner, Axel; Ringwald, Andreas; Semertzidis, Yannis; Sikivie, Pierre; Zioutas, Konstantin

    2012-01-01

    In this work, we consider searches for dark matter made of axions or axionlike particles using resonant radio frequency cavities inserted into dipole magnets from particle accelerators, wiggler magnets developed for accelerator based advanced light sources, and toroidal magnets similar to those used in particle-physics detectors. We investigate the expected sensitivity of such axionlike-particle dark matter detectors and discuss the engineering aspects of building and tuning them. Brief mention is also made of even stronger field magnets which are becoming available due to improvements in magnetic technology. It is concluded that new experiments utilizing already-existing magnets could greatly enlarge the mass region in searches for axionlike dark matter particles.

  7. Prospects for searching axion-like particle dark matter with dipole, toroidal and wiggler magnets

    International Nuclear Information System (INIS)

    In this work we consider searches for dark matter made of axions or axion-like particles (ALPs) using resonant radio frequency cavities inserted into dipole magnets from particle accelerators, wiggler magnets developed for accelerator based advanced light sources, and toroidal magnets similar to those used in particle physics detectors. We investigate the expected sensitivity of such ALP dark matter detectors and discuss the engineering aspects of building and tuning them. Brief mention is also made of even stronger field magnets that are becoming available due to improvements in magnetic technology. It is concluded that new experiments utilizing already existing magnets could greatly enlarge the mass region in searches for axion-like dark matter particles. (orig.)

  8. Development of Multi-pulse Compact Toroid Injector System for C-2U

    Science.gov (United States)

    Allfrey, I.; Garate, E.; Morehouse, M.; Roche, T.; Gota, H.; Valentine, T.; Waggoner, W.; Putvinski, S.; Cordero, M.; Asai, T.; Matsumoto, T.; Sekiguchi, J.; the TAE Team

    2015-11-01

    The C-2U experiment aims at sustaining a dynamically formed field reversed configuration (FRC) for 5 + ms via injection of 10 +MW of neutral beams. One of the systems currently used to refuel the C-2U plasma is a single pulse compact toroid injector (CTI). The CTI is a magnetized co-axial plasma gun, which generates a spheromak-like plasma that is injected into the core of the advanced beam-driven FRC of C-2U. In order to refuel the recent long-lived plasmas in C-2U, a multi-pulse CTI system, whose modular design allows for expandable burst numbers, is being designed. Details of the pulsed power systems used to energize the single pulse and the upgraded multi-pulse CTI will be discussed. Results of injector performance carried out on a dedicated test stand as well as some refueling data on C-2U will also be presented.

  9. Estimation of toroidal field coil stresses from magnetic loads in FER and NET by analytic methods

    International Nuclear Information System (INIS)

    A comparison of structural efficiency of the toroidal field (TF) coils between the Next European Torus (NET) and the Fusion Experimental Reactor (FER) machines was made. The effectiveness of their winding packs to help react loads incurred from in-plane and out-of-plane electromagnetic forces was estimated. Only analytic techniques, including mechanics of materials methods and composite mixture rules, were used. The results of NET compared well with the fairly detailed two-dimensional (2-D) and three-dimensional (3-D) finite element analysis (FEA) performed by the NET team. Similar FEAs of the Advanced Option C (ACS) version of FER have not been done, but the analytic results should be reasonable. The methodology used has been successfully programmed for use in reactor system codes

  10. Improved evolution equations for magnetic island chains in toroidal pinch plasmas subject to externally applied resonant magnetic perturbations

    International Nuclear Information System (INIS)

    An improved set of island evolution equations is derived that incorporates the latest advances in MHD (magnetohydrodynamical) theory. These equations describe the resistive/viscous-MHD dynamics of a nonlinear magnetic island chain, embedded in a toroidal pinch plasma, in the presence of a programmable, externally applied, resonant magnetic perturbation. A number of interesting example calculations are performed using the new equations. In particular, an investigation is made of a recently discovered class of multiharmonic resonant magnetic perturbations that have the novel property that they can lock resonant island chains in a stabilizing phase

  11. Toroidal mode number estimation of the edge-localized modes using the KSTAR 3-D electron cyclotron emission imaging system

    Energy Technology Data Exchange (ETDEWEB)

    Lee, J.; Yun, G. S., E-mail: gunsu@postech.ac.kr; Lee, J. E.; Kim, M.; Choi, M. J.; Lee, W. [Pohang University of Science and Technology, Pohang 790-784 (Korea, Republic of); Park, H. K. [Ulsan National Institute of Science and Technology, Ulsan 689-798 (Korea, Republic of); Domier, C. W.; Luhmann, N. C. [University of California at Davis, Davis, California 95616 (United States); Sabbagh, S. A.; Park, Y. S. [Columbia University, New York, New York 10027 (United States); Lee, S. G.; Bak, J. G. [National Fusion Research Institute, Daejeon 305-333 (Korea, Republic of)

    2014-06-15

    A new and more accurate technique is presented for determining the toroidal mode number n of edge-localized modes (ELMs) using two independent electron cyclotron emission imaging (ECEI) systems in the Korea Superconducting Tokamak Advanced Research (KSTAR) device. The technique involves the measurement of the poloidal spacing between adjacent ELM filaments, and of the pitch angle α{sub *} of filaments at the plasma outboard midplane. Equilibrium reconstruction verifies that α{sub *} is nearly constant and thus well-defined at the midplane edge. Estimates of n obtained using two ECEI systems agree well with n measured by the conventional technique employing an array of Mirnov coils.

  12. Low-frequency fluctuations in a pure toroidal magnetized plasma

    Indian Academy of Sciences (India)

    P K Sharma; R Singh; D Bora

    2009-12-01

    A magnetized, low- plasma in pure toroidal configuration is formed and extensively studied with ion mass as control parameter. Xenon, krypton and argon plasmas are formed at a fixed toroidal magnetic field of 0.024 T, with a peak density of ∼ 1011 cm-3, ∼ 4 × 1010 cm-3 and ∼ 2 × 1010 cm−3 respectively. The experimental investigation of time-averaged plasma parameter reveals that their profiles remain insensitive to ion mass and suggests that saturated slab equilibrium is obtained. Low-frequency (LF) coherent fluctuations ( < ci) are observed and identified as flute modes. Here ci represents ion cyclotron frequency. Our results indicate that these modes get reduced with ion mass. The frequency of the fluctuating mode decreases with increase in the ion mass. Further, an attempt has been made to discuss the theory of flute modes to understand the relevance of some of our experimental observations.

  13. Quasars a supermassive rotating toroidal black hole interpretation

    CERN Document Server

    Spivey, R J

    2000-01-01

    A supermassive rotating toroidal black hole (TBH) is proposed as the fundamental structure of quasars and other jet-producing active galactic nuclei. Rotating protogalaxies gather matter from the central gaseous region leading to the birth of massive toroidal stars whose internal nuclear reactions proceed very rapidly. Once the nuclear fuel is spent, gravitational collapse produces a slender ring-shaped TBH remnant. These events are typically the first supernovae of the host galaxies. Given time the TBH mass increases through continued accretion by several orders of magnitude, the event horizon swells whilst the central aperture shrinks. The difference in angular velocities between the accreting matter and the TBH induces a magnetic field that is strongest in the region of the central aperture and innermost ergoregion. Due to the presence of negative energy states when such a gravitational vortex is immersed in an electromagnetic field, circumstances are near ideal for energy extraction via non-thermal radiat...

  14. Stabilization of ballooning modes with sheared toroidal rotation

    International Nuclear Information System (INIS)

    A new code demonstrates the stabilization of MHD ballooning modes by sheared toroidal rotation. A shifted-circle model is used to elucidate the physics, and numerically reconstructed equilibria are used to analyze DIII-D discharges. In the ballooning representation, the modes shift periodically along the field line to the next point of unfavorable curvature. The shift frequency (dΩ/dq, where Ω is the angular toroidal velocity and q is the safety factor) is proportional to the rotation shear and inversely proportional to the magnetic shear. Stability improves with increasing shift frequency and, in the shifted circle model, direct stable access to the second stability regime occurs when this frequency is a fraction of the Alfven frequency, ωA = VA/qR. Shear stabilization is also demonstrated for an equilibrium reconstruction of a DIII-D VH-mode. (author). 9 refs, 3 figs

  15. Cooling of Neutron Stars with Strong Toroidal Magnetic Fields

    CERN Document Server

    Page, D; Küker, M; Page, Dany; Geppert, Ulrich; Kueker, Manfred

    2007-01-01

    We present models of temperature distribution in the crust of a neutron star in the presence of a strong toroidal component superposed to the poloidal component of the magnetic field. The presence of such a toroidal field hinders heat flow toward the surface in a large part of the crust. As a result, the neutron star surface presents two warm regions surrounded by extended cold regions and has a thermal luminosity much lower than in the case the magnetic field is purely poloidal. We apply these models to calculate the thermal evolution of such neutron stars and show that the lowered photon luminosity naturally extends their life-time as detectable thermal X-ray sources.

  16. Experimental investigation of transitional flow in a toroidal pipe

    CERN Document Server

    Kühnen, J; Hof, B; Kuhlmann, H

    2015-01-01

    The flow instability and further transition to turbulence in a toroidal pipe (torus) with curvature (tube-to-coiling diameter) 0.049 is investigated experimentally. The flow inside the toroidal pipe is driven by a steel sphere fitted to the inner pipe diameter. The sphere is moved with constant azimuthal velocity from outside the torus by a moving magnet. The experiment is designed to investigate curved pipe flow by optical measurement techniques. Using stereoscopic particle image velocimetry, laser Doppler velocimetry and pressure drop measurements, the flow is measured for Reynolds numbers ranging from 1000 to 15000. Time- and space-resolved velocity fields are obtained and analysed. The steady axisymmetric basic flow is strongly influenced by centrifugal effects. On an increase of the Reynolds number we find a sequence of bifurcations. For Re=4075 a supercritical bifurcation to an oscillatory flow is found in which waves travel in the streamwise direction with a phase velocity slightly faster than the mean...

  17. Control and monitoring of the Tore Supra toroidal superconducting coils

    International Nuclear Information System (INIS)

    Light nuclei controlled fusion reactions are seen as a possible way to produce nuclear energy. For this reason, the interest in hot plasma researches in tokamaks has increased. The Tore Supra main characteristic is related to the superconducting magnet coils. They allow a suitable energy balance, however, they require an accurate and preventive fault detection. The Tore Supra machine and the different methods to detect a transition (from superconducting to normal mode) in the toroidal coils are described. The voltage of the coils, the pressure of the helium superfluid at 1.8 K and the electric current in the circuit parallel resistances, are measured. A computer aided control system allows the toroidal field monitoring (current in the coils, fault detection). The superconducting magnet configuration chosen for Tore Supra seems to be suitable for future large Tokamak devices

  18. ATLAS barrel toroid integration and test area in building 180

    CERN Multimedia

    Maximilien Brice

    2003-01-01

    The ATLAS barrel toroid system consists of eight coils, each of axial length 25.3 m, assembled radially and symmetrically around the beam axis. The coils are of a flat racetrack type with two 'double-pancake' windings made of 20.5 kA aluminium-stabilized niobium-titanium superconductor. The barrel toroid is being assembled in building 180 on the Meyrin site. In the first phase of assembly, the coils are packed into their aluminium-alloy casing. These photos show the double-pancake coils from ANSALDO and the coil casings from ALSTOM. In the foreground is the tooling from COSMI used to turn over the coil casings during this first phase. In the right background is the yellow lifting gantry manufactured at JINR-Dubna, Russia which will transport the coil casings to a heating table for prestressing. Two test benches with magnetic mirror are also visible.

  19. On the radiation of electric, magnetic and toroidal dipoles

    International Nuclear Information System (INIS)

    We consider the radiation of electric, magnetic and toroidal dipoles uniformly moving in unbounded medium (this corresponds to the Tamm-Frank problem). The densities of these dipoles are obtained from the corresponding charge-current densities in an infinitesimal limit. The behaviour of radiation intensities in the neighbourhood of the Cherenkov threshold β = 1/n is investigated. The frequency and velocity regions are defined where radiation intensities are maximal. The comparison with previous attempts is given. We consider also the radiation of electric, magnetic and toroidal dipoles uniformly moving in medium, in a finite space interval (this corresponds to the Tamm problem). The properties of radiation arising from the precession of a magnetic dipole are studied

  20. Neoclassical electron and ion transport in toroidally rotating plasmas

    Energy Technology Data Exchange (ETDEWEB)

    Sugama, H.; Horton, W.

    1997-01-01

    Neoclassical transport processes of electrons and ions are investigated in detail for toroidally rotating axisymmetric plasmas with large flow velocities on the order of the ion thermal speed. The Onsager relations for the flow-dependent neoclassical transport coefficients are derived from the symmetry properties of the drift kinetic equation with the self-adjoint collision operator. The complete neoclassical transport matrix with the Onsager symmetry is obtained for the rotating plasma consisting of electrons and single-species ions in the Pfirsch-Schlueter and banana regimes. It is found that the inward banana fluxes of particles and toroidal momentum are driven by the parallel electric field, which are phenomena coupled through the Onsager symmetric off-diagonal coefficients to the parallel currents caused by the pressure gradient and by the flow shear, respectively. (author)

  1. Modelling of density limit phenomena in toroidal helical plasmas

    Energy Technology Data Exchange (ETDEWEB)

    Itoh, K. [National Inst. for Fusion Science, Toki, Gifu (Japan); Itoh, S.-I. [Kyushu Univ., Fukuoka (Japan). Research Inst. for Applied Mechanics; Giannone, L. [Max Planck Institut fuer Plasmaphysik, EURATOM-IPP Association, Garching (Germany)

    2000-03-01

    The physics of density limit phenomena in toroidal helical plasmas based on an analytic point model of toroidal plasmas is discussed. The combined mechanism of the transport and radiation loss of energy is analyzed, and the achievable density is derived. A scaling law of the density limit is discussed. The dependence of the critical density on the heating power, magnetic field, plasma size and safety factor in the case of L-mode energy confinement is explained. The dynamic evolution of the plasma energy and radiation loss is discussed. Assuming a simple model of density evolution, of a sudden loss of density if the temperature becomes lower than critical value, then a limit cycle oscillation is shown to occur. A condition that divides the limit cycle oscillation and the complete radiation collapse is discussed. This model seems to explain the density limit oscillation that has been observed on the W7-AS stellarator. (author)

  2. A comparison between linear and toroidal Extrap systems

    International Nuclear Information System (INIS)

    The Extrap scheme consists of a Z-pinch immersed in an octupole field generated by currents in a set of external conductors. A comparison between linear and toroidal Extrap geometry is made in this paper. As compared to toroidal systems, linear geometry has the advantages of relative simplicity and of a current drive by means of electrodes. Linear devices are convenient for basic studies of Extrap, at moderately high pinch currents and plasma temperatures. Within the parameter ranges of experiments at high pinch currents and plasma temperatures, linear systems have on the other hand some substantial disadvantages, on account of the plasma interaction with the end regions. This results in a limitation of the energy confinement time, and leads in the case of an ohmically heated plasma to excessively high plasma densities and small pinch radii which also complicate the introduction of the external conductors. (author)

  3. An Overview of Plasma Confinement in Toroidal Systems

    CERN Document Server

    Dini, Fatemeh; Amrollahi, Reza; Khorasani, Sina

    2009-01-01

    This overview presents a tutorial introduction to the theory of magnetic plasma confinement in toroidal confinement systems with particular emphasis on axisymmetric equilibrium geometries, and tokamaks. The discussion covers three important aspects of plasma physics: Equilibrium, Stability, and Transport. The section on equilibrium will go through an introduction to ideal magnetohydrodynamics, curvilinear system of coordinates, flux coordinates, extensions to axisymmetric equilibrium, Grad-Shafranov Equation (GSE), Green's function formalism, as well as analytical and numerical solutions to GSE. The section on stability will address topics including Lyapunov Stability in nonlinear systems, energy principle, modal analysis, and simplifications for axisymmetric machines. The final section will consider transport in toroidal systems. We present the flux-surface-averaged system of equations describing classical and non-classical transport phenomena. Applications to the small-sized high-aspect-ratio Damavand tokam...

  4. Initial value problem of the toroidal ion temperature gradient mode

    International Nuclear Information System (INIS)

    The initial value problem of the toroidal ion temperature gradient mode is studied based on the Laplace transform of the ion gyrokinetic equation and the electron Boltzmann relation with the charge neutrality condition. Due to the toroidal magnetic drift, the Laplace-transformed density and potential perturbations have a branch cut as well as poles on the complex-frequency plane. The inverse Laplace transform shows that the temporal evolution of the density and potential perturbations consists of the normal modes and the continuum mode, which correspond to contributions from the poles and the branch cut, respectively. The normal modes have exponential time dependence with the eigenfrequencies determined by the dispersion relation while the continuum mode shows power-law decay oscillation. For the stable case, the long-time asymptotic behavior of the potential and density perturbations is dominated by the continuum mode which decays slower than the normal modes. (author)

  5. Mechanical tests of the ITER toroidal field model coil

    International Nuclear Information System (INIS)

    The ITER toroidal field model coil (TFMC) was designed to allow an overall mechanical test representative of the ITER toroidal field (TF) coils. The paper details the mechanical tests performed, compares them to model predictions and discusses the experience gained in the understanding of the mechanical behaviour of the ITER TF coils. The good agreement found between prediction given by a finite element model and mechanical measurements performed during the tests demonstrates that coil mechanical behaviour is well understood. The reproducibility of the evolution of stresses and coil deformation during testing including cycling tests showed that no measurable degradation of the mechanical properties of the coil occurred. This test contributed to the qualification of the design and manufacturing procedures of the ITER TF coils

  6. Toroidal AC transformer for beam intensity measurements in CSR

    International Nuclear Information System (INIS)

    The intensity of a pulsed beam of charged particles in the Cooling Storage Ring Project of Heavy Ion Research Facility in Lanzhou (HIRFL-CSR) will be measured with a toroidal current transformer. By comparing and analyzing the properties of kinds of magnetic cores, a strip wound toroidal core is adopted, which is made of a high-permeability alloy and can measure a pulsed beam with frequency range of 0.2 to 2 MHz. The permeability of Fe-based nanocrystalline alloy varying with frequency is measured and the noises in the circuit are analyzed. By adding a low-noise operational amplifier into the circuit, the current down to 1 μA can be detected

  7. Counterformal contacts of full toroidal continuously variable transmission

    Institute of Scientific and Technical Information of China (English)

    ATTIA Nabil Abdulla; QIN Da-tong

    2005-01-01

    The point and the line contacts of a toroidal continuously variable transmission (CVT) are studied. The contact shapes between the roller and input and output disks are formulated by using the classical Hertz contact theory. Based on the formulated equations, different system factors affecting the maximum Hertz stress in the elliptical and strip contacts of the full toroidal CVT are explored, which include the properties of the contacting material (Young's modulus), operating condition (pushing load) and geometrical parameters (aspect cavity ratio, aspect roller ratio). The comparative results reveal the relations between the maximum Hertz stress and the speed ratio in the form of graphs. These graphs give useful information for designer to know the maximum Hertz stress during operation in such systems.

  8. Nonlinear particle simulation of ion cyclotron waves in toroidal geometry

    Energy Technology Data Exchange (ETDEWEB)

    Kuley, A., E-mail: akuley@uci.edu; Lin, Z. [Department of Physics and Astronomy, University of California Irvine, CA-92697 (United States); Bao, J. [Fusion Simulation Center, Peking University, Beijing (China); Department of Physics and Astronomy, University of California Irvine, CA-92697 (United States); Wei, X. S.; Xiao, Y. [Institute of Fusion Theory and Simulation, Zhejiang University, Hangzhou (China)

    2015-12-10

    Global particle simulation model has been developed in this work to provide a first-principles tool for studying the nonlinear interactions of radio frequency (RF) waves with plasmas in tokamak. In this model, ions are considered as fully kinetic particles using the Vlasov equation and electrons are treated as guiding centers using the drift kinetic equation with realistic electron-to-ion mass ratio. Boris push scheme for the ion motion has been developed in the toroidal geometry using magnetic coordinates and successfully verified for the ion cyclotron and ion Bernstein waves in global gyrokinetic toroidal code (GTC). The nonlinear simulation capability is applied to study the parametric decay instability of a pump wave into an ion Bernstein wave side band and a low frequency ion cyclotron quasi mode.

  9. Stability analysis of electromagnetic interchange modes in toroidal geometry

    International Nuclear Information System (INIS)

    An investigation is presented of how the stability of collisionless electromagnetic interchange modes depends on εn (the ratio of the magnetic drift frequency to the diamagnetic drift frequency), the ion temperature gradient and the electron temperature gradient. A linear two fluid model in toroidal geometry is used. The eigenvalue problem is solved analytically and then the complex frequency is solved numerically from the dispersion relation. Comparison is made with Merciers criterion, in the magnetohydrodynamic limit. The most important observed effects are : 1. When εn increases Merciers criterion becomes increasingly incorrect. The toroidal system becomes more stable than Merciers criterion predicts. εn is large in regions where we have flat density profiles, Ln >> LB (the characteristic scale length of density and magnetic field inhomogeneities). 2. Finite ηi (Ln / LTi) may cause instability below the critical pressure gradient in the Mercier criterion

  10. A novel electron density reconstruction method for asymmetrical toroidal plasmas

    International Nuclear Information System (INIS)

    A novel reconstruction method is developed for acquiring the electron density profile from multi-channel interferometric measurements of strongly asymmetrical toroidal plasmas. It is based on a regularization technique, and a generalized cross-validation function is used to optimize the regularization parameter with the aid of singular value decomposition. The feasibility of method could be testified by simulated measurements based on a magnetic configuration of the flexible helical-axis heliotron device, Heliotron J, which has an asymmetrical poloidal cross section. And the successful reconstruction makes possible to construct a multi-channel Far-infrared laser interferometry on this device. The advantages of this method are demonstrated by comparison with a conventional method. The factors which may affect the accuracy of the results are investigated, and an error analysis is carried out. Based on the obtained results, the proposed method is highly promising for accurately reconstructing the electron density in the asymmetrical toroidal plasma

  11. Compact toroid development. Resource needs for field reversed configurations

    International Nuclear Information System (INIS)

    This document contains the goals and technical approach for the five years 1985 to 1990 for the investigation of the properties of a magnetic configuration for plasma confinement identified as the field reversed configuration (FRC). The included material represents the third phase of FRC program planning. The first was reported in DOE/ER-0160: Compact Toroid Development, Status and Technical Needs, February 1983. The second was reported in DOE/ER-0197: Compact Toroid Development, Activity Plans for Field Reversed Configurations, June 1984. This planning identifies the facilities and resources needed to achieve the goals set forth in the first two phases. The information in this document is based on technical recommendations provided by the FRC community

  12. Magnetohydrodynamic equilibrium of axisymmetric systems with toroidal rotation

    International Nuclear Information System (INIS)

    A model for studying magnetohydrodynamic equilibrium of axisymetrically confined plasma with toroidal rotation, extended to the Grad. Shafranov equation is presented. The expression used for the scalar pressure is modifiec, and the influence of toroidal magnetic field is included, The equation for general motion of axisymetrically confined plasma, particularizing for rotation movements is described. Two cases are compared: one supposes the entropy as a function of poloidal magnetic flux and other supposes the temperature as a function of flux. The equations for these two cases obtaining a simplified expression by others approximations are established. The proposed model is compared with Shibata model, which uses density as function of flux, and with the ideal spheromak model. A set of cases taking in account experimental data is studied. (M.C.K.)

  13. Superconducting toroidal magnets for fusion feasibility experiments and power reactors

    International Nuclear Information System (INIS)

    It has been recognized that large superconducting magnets will have to be developed in order to obtain power economically from a thermonuclear reactor. In the present paper, compelling reasons are offered to illustrate how vital they are even for the sizes envisioned for hydrogen feasibility and D-T burning experiments. Detailed discussion is given on the type of magnets used for the plasma confinement in a tokamak-type machine. Illustrations are given to show that their development is within the present technological progress of superconductivity. The methods used to estimate the cost of such a toroidal system are provided along with how the cost varies with changes in magnet aspect ratio, major radius (proportional to Rsup(1.95) and stored energy (proportional to Esub(S)sup(0.65)). The latter quantity is presented as a valid figure of merit for quickly estimating the cost of any large superconducting toroidal system. (author)

  14. Toroidal nano-traps for cold polar molecules

    OpenAIRE

    Salhi, Marouane; Passian, Ali; Siopsis, George

    2015-01-01

    Electronic excitations in metallic nanoparticles in the optical regime that have been of great importance in surface enhanced spectroscopy and emerging applications of molecular plasmonics, due to control and confinement of electromagnetic energy, may also be of potential to control the motion of nanoparticles and molecules. Here, we propose a concept for trapping polarizable particles and molecules using toroidal metallic nanoparticles. Specifically, gold nanorings are investigated for their...

  15. Path Integral Quantization for a Toroidal Phase Space

    OpenAIRE

    Bodmann, Bernhard G.; Klauder, John R.

    1999-01-01

    A Wiener-regularized path integral is presented as an alternative way to formulate Berezin-Toeplitz quantization on a toroidal phase space. Essential to the result is that this quantization prescription for the torus can be constructed as an induced representation from anti-Wick quantization on its covering space, the plane. When this construction is expressed in the form of a Wiener-regularized path integral, symmetrization prescriptions for the propagator emerge similar to earlier path-inte...

  16. Toroidal field coil system for STARFIRE, a preliminary assessment

    International Nuclear Information System (INIS)

    An important element of STARFIRE is the 12-coil superconducting toroidal field coil system which is required to generate 5.6 tesla at the 7.0 m plasma axis, with a peak-to-peak field ripple of 1% (maximum). Internal spatial requirements dictate a clear bore about 15 1/2 m high x 10 m wide, resulting in a total stored energy of 67 GJ

  17. Operating tokamaks with steady-state toroidal current

    International Nuclear Information System (INIS)

    Continuous operation of a tokamak requires, among other things, a means of continuously providing the toroidal current. Various methods have been proposed to provide this current including methods which utilize radio-frequency waves in any of several frequency regimes. Here we elaborate on the prospects of incorporating these current-drive techniques in tokamak reactors, concentrating on the theoretical minimization of the power requirements

  18. An approach to cylindrical approximation of toroidal geometry

    International Nuclear Information System (INIS)

    Neutron transport processes in Tokamak fusion devices are described with same mathematical equipment as that used in fission reactor calculations. The aim of this paper is to show some of these methods in toroidal geometry problem. A new approach to cylindrical approximation is described. All calculations are performed by ANISN one-dimensional Sn code. To validate the present method, comparison have been done with Monte Carlo results, as well as with calculations done on previous geometry approximation (author)

  19. Stability of a stiffened toroidal sector under uniform external pressure

    International Nuclear Information System (INIS)

    This paper present the results of a stability analysis on a sector of the FTU (Frascati Tokamak Upgrade) toroidal vacuum vessel. FTU is an experimental machine, now under construction, mainly devoted to the study of the effects of lower hybrid radiofrequency heating on plasmas in reactor relevant conditions. Its vacuum chamber is a stainless steel structure completely welded with a major radius of 0.935 m and a minor radius of 0.335 m consisting of 12 toroidal thin sector joined together by thick ribs. This structure is loaded by comprensive electromagnetic forces both in toroidal and in radial direction that can create instability conditions. One of the major problems in its design is to determine the points where this phenomenon is likely to occur in order to avoid dangerous buckling situations. Theoretical analysis of the stability behaviour of one of these sector has been conducted by means of the ABAQUAS finite element code. The critical load has been determined by a classical algorithm and by the modified Riks methods. Both methods have given similar results in an elastic analysis. Furthermore the second one has been applied also using an elastoplastic model of the material to determine the critical load and the post buckling behaviour of the structure. Experimental tests have been conducted on a full scale model of the toroidal sector. The model has been placed in a large tank filled with water where the pressure has been gradually increased up to the collapse of the structure. The theoretical and experimental results have been compared and a good agreement has been found between them

  20. Self-Sustained Magnetic Braiding in Toroidal Plasmas

    OpenAIRE

    Itoh, K; Fukuyama, A.; Itoh, S.-I.; Yagi, M.; Azumi, M.

    1994-01-01

    Theory for the magnetic braiding in toroidal plasmas, which is caused by microscopic pressure-gradient-driven turbulence, is developed. When the pressure gradient exceeds a threshold, the self-sustaining of the magnetic braiding and enhanced anomalous transport occur. The balance between the nonlinear destabilization and nonlinear stabilization, which determines the stationary turbulence, is solved analytically for the case of interchange mode. The enhanced thermal conductivity and magneti...

  1. Vacuum magnetic fields in the toroidal Extrap device

    International Nuclear Information System (INIS)

    A model of the ring system of the Extrap T1 device is developed. The model is used for calculating the distribution of poloidal flux and the vacuum magnetic field in the device. Numerical data from the model are compared with measurements. Effects of the vacuum vessel resistivity are discussed qualitatively. Measured profiles of the toroidal and the vertical bias magnetic field in the device are presented. Time constants of the vacuum vessel and the ring structure are estimated. (authors)

  2. From toroidal to rod-like condensates of semiflexible polymers

    OpenAIRE

    Hoang, Trinh Xuan; Giacometti, Achille; Podgornik, Rudolf; Nguyen, Nhung T. T.; Banavar, Jayanth R.; Maritan, Amos

    2014-01-01

    The competition between toroidal and rod-like conformations as possible ground states for DNA condensation is studied as a function of the stiffness, the length of the DNA and the form of the long-range interactions between neighboring molecules, using analytical theory supported by Monte Carlo simulations. Both conformations considered are characterized by a local nematic order with hexagonal packing symmetry of neighboring DNA molecules, but differ in global configuration of the chain and t...

  3. Interferometry on the Weapons Laboratory's compact toroid experiment

    International Nuclear Information System (INIS)

    Interferometric measurements of line averaged free electron density are being taken as part of the compact toroid experiment at the Weapons Laboratory's High Energy Plasma Division. A double pass optical interferometer using either a CO2 far-infrared laser or a He-Ne laser and a separate single pass millimeter wave interferometer is used. With this wide range of wavelengths, a very wide range of density measurements were made of the various states of the experiment

  4. Fuel licensing process for an industrial use. ATF licensing process for an industrial use - Utility's perspective

    International Nuclear Information System (INIS)

    To develop and license a breakthrough nuclear fuel technology for commercial use is becoming challenging. All the former safety analysis design limits (SAFDLs) defined in the 1970's for the standard UO2-Zr fuels, might no longer be applicable. Identification of the appropriate safety analysis design limits For each type of innovative fuel, the developers will have to identify and investigate all the possible failure/ruins scenarios (not only those related to severe accidents but also those related to normal operation). In order to save time and to focus on the best options, those failure scenarios (which could be 'killers' for the ATF concept) have to be determined early enough in the development process. Based on the above failure scenarios, the developers will have to propose the licensing limits (and the experimental protocol to determine and to justify them). As mentioned earlier, the licensing limits should not be defined against the accidental conditions only. For the operators, the (good) in-reactor fuel behaviour is crucial. As an example, in the case of the new fuel concepts coming with an outer coating, it is important to include the analysis of the consequences of the loss of this protective outer layer in the licensing process due to a manufacturing defect or an inevitable in-reactor fretting wear. Obviously, the new/specific SAFDLs will have to be endorsed by the regulators (which could be a long process by itself). Identification of a commercial reactor to irradiate the first ATF A commercial NPP is not a material test reactor (MTR); irradiating lead test fuel rods (LTFRs) or lead test assemblies (LTAs) implies strict requirements regarding the manufacturing processes [which should not include chemicals (additives or solvents) potentially incompatible with the nuclear technical specifications], the compatibility with the hosting fuel core (in terms of geometry, enrichment, thermal hydraulic performances, etc.) and the robustness and the

  5. Toroidal plasma reactor with low external magnetic field

    International Nuclear Information System (INIS)

    A toroidal pinch configuration with safety factor q < 0.5 decreasing from the center to periphery without field reversal is proposed. This is capable of containing high pressure plasma with only small toroidal external magnetic field. Sufficient conditions for magnetohydrodynamic stability are fulfilled in this configuration. The stability is studied by constructing the Lyapunov functional and investigating its extrema both analytically and numerically. Comparison of the Lyapunov stability conditions with the conventional linear theory is carried out. Stable configurations are found with average β near 15%, with magnetic field associated mainly with plasma current. The β value calculated with the external magnetic field can be over 100%. Fast charged particles produced by fusion reactions are asymmetrically confined by the poloidal magnetic field (and due to the lack of strong toroidal field). They thus generate a current in the noncentral part of plasma to reinforce the poloidal field. This current drive can sustain the monotonic decrease of q with radius. 20 refs., 9 figs

  6. Sustainment of spheromak plasma by driving the toroidal current

    International Nuclear Information System (INIS)

    Spheromak plasma productions by means of quasi-static method on the basis of z-discharge and theta-discharge have been investigated using the machine named TS-3. This machine consists of a SUS vacuum vessel with an inner diameter of 76 cm and an axial length of 95 cm, two internal poloidal coils enclosed with SUS thin cases with a major diameter of 43 cm and an axial separation of 39 cm, and two sets of eight pairs of electrodes around each poloidal coil. Up to 0.2 T vertical magnetic field can be applied using an external DC mirror type magnet. Either one or two isolated spheromak(s) can be generated by the selection of sets of electrodes in proper manner. An optional current transformer with an outer cylinder diameter of 9 cm installed along the major symmetric axis of the vessel enables us to perform toroidal current driving of spheromak plasma. Spheromak plasmas produced in He has of about 10 mTorr have a decay time of about 30 micro sec. with the center conductor when it has no current for the toroidal current driving. However, when a flux change of 30 to 60 Wb/s is given to the center coil during 100 micro sec after the initiation of the spheromak configuration, the sustainment of the configuration is observed by the measurement of both poloidal and toroidal field spatial profile

  7. Neoclassical offset toroidal velocity and auxiliary ion heating in tokamaks

    Science.gov (United States)

    Lazzaro, E.

    2016-05-01

    In conditions of ideal axisymmetry, for a magnetized plasma in a generic bounded domain, necessarily toroidal, the uniform absorption of external energy (e.g., RF or any isotropic auxiliary heating) cannot give rise to net forces or torques. Experimental evidence on contemporary tokamaks shows that the near central absorption of RF heating power (ICH and ECH) and current drive in presence of MHD activity drives a bulk plasma rotation in the co- I p direction, opposite to the initial one. Also the appearance of classical or neoclassical tearing modes provides a nonlinear magnetic braking that tends to clamp the rotation profile at the q-rational surfaces. The physical origin of the torque associated with P RF absorption could be due the effects of asymmetry in the equilibrium configuration or in power deposition, but here we point out also an effect of the response of the so-called neoclassical offset velocity to the power dependent heat flow increment. The neoclassical toroidal viscosity due to internal magnetic kink or tearing modes tends to relax the plasma rotation to this asymptotic speed, which in absence of auxiliary heating is of the order of the ion diamagnetic velocity. It can be shown by kinetic and fluid calculations, that the absorption of auxiliary power by ions modifies this offset proportionally to the injected power thereby forcing the plasma rotation in a direction opposite to the initial, to large values. The problem is discussed in the frame of the theoretical models of neoclassical toroidal viscosity.

  8. 3D toroidal physics: Testing the boundaries of symmetry breakinga)

    Science.gov (United States)

    Spong, Donald A.

    2015-05-01

    Toroidal symmetry is an important concept for plasma confinement; it allows the existence of nested flux surface MHD equilibria and conserved invariants for particle motion. However, perfect symmetry is unachievable in realistic toroidal plasma devices. For example, tokamaks have toroidal ripple due to discrete field coils, optimized stellarators do not achieve exact quasi-symmetry, the plasma itself continually seeks lower energy states through helical 3D deformations, and reactors will likely have non-uniform distributions of ferritic steel near the plasma. Also, some level of designed-in 3D magnetic field structure is now anticipated for most concepts in order to provide the plasma control needed for a stable, steady-state fusion reactor. Such planned 3D field structures can take many forms, ranging from tokamaks with weak 3D edge localized mode suppression fields to stellarators with more dominant 3D field structures. This motivates the development of physics models that are applicable across the full range of 3D devices. Ultimately, the questions of how much symmetry breaking can be tolerated and how to optimize its design must be addressed for all fusion concepts. A closely coupled program of simulation, experimental validation, and design optimization is required to determine what forms and amplitudes of 3D shaping and symmetry breaking will be compatible with the requirements of future fusion reactors.

  9. Reduction of toroidal ripple by using high Tc conductors

    International Nuclear Information System (INIS)

    The loss of alpha particles in a rippled toroidal field is one of the most critical issues for the design of tokamak reactors, because it has direct impacts on the design of toroidal field (TF) coils and the first wall. In the preliminary design of the ITER, the alpha particle ripple loss and the additional first wall heat load due to such loss has been assessed. From these assessments the maximum ripples (Bmax - Bmin)/(Bmax + Bmin), at the plasma edge is required to be decreased to 1 - 1.5%. There are several possible ways to decrease the ripple value without changing the TF coil shape. One of them is to use ferromagnetic balls in the vacuum vessel under the outer TF coil legs. Preliminary estimations show that in this way the ripple can be decreased by a factor of 2. In this paper, a new method to reduce the toroidal ripple using high Tc superconductors is presented. High Tc superconductor have the advantage of working above the boiling temperature of liquid nitrogen and they have other properties that make their practical applications. For example, they behave as a ferromagnetic or diamagnetic material depending on their magnetization. Therefore, if superconductors are appropriately arranged and magnetized, they decrease the maximum ripple at the plasma edge to the required value

  10. Modeling and analysis of silicon-embedded MEMS toroidal inductors

    Science.gov (United States)

    Araghchini, M.; Lang, J. H.

    2013-12-01

    This paper presents the modeling and analysis of three-dimensional silicon-embedded toroidal inductors designed for power converter applications. Special attention is given to modeling phenomena associated with the presence of silicon, namely an increase in loss and parasitic capacitance. Silicon-embedded inductors can be fabricated with silicon inside the donut-shaped toroidal core and inside the donut hole, as well as with silicon above, below and outside the inductor. It is argued here that, with the exception of the losses in the core at high doping densities, the losses in the silicon can be tolerated in many power applications, making fully-integrated silicon-embedded air-core inductors viable for power applications. An equivalent circuit model is presented for such inductors which captures the stored magnetic energy, the parasitic electric energy stored between the windings and the silicon, the loss in the toroidal windings, and the electrically- and magnetically-driven losses inside the silicon. The model developed here is verified against experimental data, and the comparison shows a good match over the frequency range of interest to power electronics applications.

  11. Measurement of toroidal and poloidal plasma rotation in TCA

    International Nuclear Information System (INIS)

    With optimal observation geometry we have measured both the toroidal and poloidal rotation velocities in the edge and in the bulk of the TCA plasma. Regular calibration and correction for variations in the spectrometer temperature permitted a measurement with an error of ∼0.5 km/s which is an order of magnitude smaller than the range of measured velocities. In general, changes in the velocities are observed to be stronger and faster in the plasma edge than in the plasma bulk. With increasing density, the toroidal velocity is observed to change sign and follow the plasma density, while the poloidal velocity increases. These two effects lead to an increase in the absolute value of the radial electric field. With very strong gas puffing, the toroidal velocity is observed to again reverse and tend to zero, an effect which is stronger as the gradient of the density ramp is increased. Comparison between gas puffing and high power AWH does not show a significant difference in the radial electric field that could be responsible for the large associated density rise, which still remains unexplained. (author) 4 figs., 2 refs

  12. Axisymmetric toroidal equilibrium with flow and anisotropic pressure

    International Nuclear Information System (INIS)

    Axisymmetric toroidal plasma equilibria with mass flows and anisotropic pressure are investigated. The equilibrium system is derived for a general functional form of the pressures, which includes both fluid models, such as the magnetohydrodynamic (MHD) and the double-adiabatic models, and Grad's guiding centre model. This allows for detailed comparisons between the models and clarifies how the 'first hyperbolic region', occurring in the fluid theory when the poloidal flow is of the order of the poloidal sound speed, can be eliminated in guiding centre theory. In the case of a pure toroidal rotation, macroscopic equations of state are derived from the guiding centre model, characterized by a parallel temperature that is constant on each magnetic surface and a perpendicular temperature that varies with the magnetic field. The outward centrifugal shifts of the magnetic axis and of the mass density profile, due to toroidal rotation, are increased by anisotropy. The guiding centre model shows that poloidal flow produces an inward shift of the density profile, in contrast with the MHD result. (author) 1 fig., 1 tab., 17 refs

  13. Point-to-point focusing equation for double toroidal analyzer

    International Nuclear Information System (INIS)

    Highlights: • We deduce a general and simple equation for the point-to-point focusing in the radial plane of double toroidal analyzer (DTA). • Graphically solve the equation to get the geometrical configuration of DTA for a given situation. • The obtained geometry is in good agreement with the trajectory simulation by SIMION program, which indicates that the equation is quite useful in analytically design of DTA. - Abstract: Toroidal analyzer (TA) has high detection efficiency due to the parallel measurement of the energies and the angles of charged particles in wide range. Compared to a normal TA, double toroidal analyzer (DTA) has the advantages of flat focal plane and normal incidence angles of particles onto the detector surface. However, no analytical formula is available to describe the point-to-point focusing in its radial plane. In the present work, a simple equation for the point-to-point focusing is obtained. The calculated deflection angles using this equation are in good agreement with the trajectory simulations. This indicates the equation could be quite useful for the future analytical design of DTA

  14. 3D toroidal physics: Testing the boundaries of symmetry breaking

    Energy Technology Data Exchange (ETDEWEB)

    Spong, Donald A., E-mail: spongda@ornl.gov [Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831-6169 (United States)

    2015-05-15

    Toroidal symmetry is an important concept for plasma confinement; it allows the existence of nested flux surface MHD equilibria and conserved invariants for particle motion. However, perfect symmetry is unachievable in realistic toroidal plasma devices. For example, tokamaks have toroidal ripple due to discrete field coils, optimized stellarators do not achieve exact quasi-symmetry, the plasma itself continually seeks lower energy states through helical 3D deformations, and reactors will likely have non-uniform distributions of ferritic steel near the plasma. Also, some level of designed-in 3D magnetic field structure is now anticipated for most concepts in order to provide the plasma control needed for a stable, steady-state fusion reactor. Such planned 3D field structures can take many forms, ranging from tokamaks with weak 3D edge localized mode suppression fields to stellarators with more dominant 3D field structures. This motivates the development of physics models that are applicable across the full range of 3D devices. Ultimately, the questions of how much symmetry breaking can be tolerated and how to optimize its design must be addressed for all fusion concepts. A closely coupled program of simulation, experimental validation, and design optimization is required to determine what forms and amplitudes of 3D shaping and symmetry breaking will be compatible with the requirements of future fusion reactors.

  15. Toroidal Continuously Variable Transmission Systems: Terminology and Present Studies

    Directory of Open Access Journals (Sweden)

    Ahmet YILDIZ

    2014-04-01

    Full Text Available The use of continuously variable transmission systems in many different areas such as aerospace, robotics, machinery and automotive industries as an alternative to conventional speed changers with constant ratio becomes widely.Especially in the automotive industry, these systems have been used increasingly, since they enable that internal combustion engines in vehicles run at optimal speeds, and consequently provide considerable fuel savings and therefore lower emission values and also they provide powerful acceleration and quiet working. CVT systems have several constructive variants such as belted, chained, balled, toroidal etc. In this paper, toroidal CVT systems based on elastohydrodynamic principles are concerned with, and fundamental works of last two decades in this field are reviewed. However, the relevant terminology and dynamics along with the control of these systems are briefly treated for better understanding of the literature mentioned. Attention is drawn to the lack of some significant issues in present research works, and potential future works are pointed out. This paper, to the authors’ knowledge, will be the first review on toroidal CVT systems in Turkish literature

  16. Expansions of non-symmetric toroidal magnetohydrodynamic equilibria

    Science.gov (United States)

    Weitzner, Harold

    2016-06-01

    Expansions of non-symmetric toroidal ideal magnetohydrodynamic equilibria with nested flux surfaces are carried out for two cases. The first expansion is in a topological torus in three dimensions, in which physical quantities are periodic of period 2 π in y and z. Data is given on the flux surface x = 0. Despite the possibility of magnetic resonances the power series expansion can be carried to all orders in a parameter which measures the flux between x = 0 and the surface in question. Resonances are resolved by appropriate addition resonant fields, as by Weitzner, [Phys. Plasmas 21, 022515 (2014)]. The second expansion is about a circular magnetic axis in a true torus. It is also assumed that the cross section of a flux surface at constant toroidal angle is approximately circular. The expansion is in an analogous flux coordinate, and despite potential resonance singularities, may be carried to all orders. Non-analytic behavior occurs near the magnetic axis. Physical quantities have a finite number of derivatives there. The results, even though no convergence proofs are given, support the possibility of smooth, well-behaved non-symmetric toroidal equilibria.

  17. miR-214 protects erythroid cells against oxidative stress by targeting ATF4 and EZH2.

    Science.gov (United States)

    Gao, Ming; Liu, Yun; Chen, Yue; Yin, Chunyang; Chen, Jane-Jane; Liu, Sijin

    2016-03-01

    Nuclear factor (erythroid-derived 2) like 2 (Nrf2) is a key regulator in protecting cells against stress by targeting many anti-stress response genes. Recent evidence also reveals that Nrf2 functions partially by targeting mircroRNAs (miRNAs). However, the understanding of Nrf2-mediated cytoprotection through miRNA-dependent mechanisms is largely unknown. In the current study, we identified a direct Nrf2 targeting miRNA, miR-214, and demonstrated a protective role of miR-214 in erythroid cells against oxidative stresses generated by radiation, excess iron and arsenic (As) exposure. miR-214 expression was transcriptionally repressed by Nrf2 through a canonical antioxidant response element (ARE) within its promoter region, and this repression is ROS-dependence. The suppression of miR-214 by Nrf2 could antagonize oxidative stress-induced cell death in erythroid cells by two ways. First, miR-214 directly targeted ATF4, a crucial transcriptional factor involved in anti-stress responses, down regulation of miR-214 releases the repression of ATF4 translation and leads to increased ATF4 protein content. Second, miR-214 was able to prevent cell death by targeting EZH2, the catalytic core component of PRC2 complex that is responsible for tri-methylation reaction at lysine 27 (K27) of histone 3 (H3) (H3K27me3), by which As-induced miR-214 reduction resulted in an increased global H3K27me3 level and a compromised overexpression of a pro-apoptotic gene Bim. These two pathways downstream of miR-214 synergistically cooperated to antagonize erythroid cell death upon oxidative stress. Our combined data revealed a protective role of miR-214 signaling in erythroid cells against oxidative stress, and also shed new light on Nrf2-mediated cytoprotective machinery. PMID:26791102

  18. Aspergillus nidulans transcription factor AtfA interacts with the MAPK SakA to regulate general stress responses, development and spore functions.

    Science.gov (United States)

    Lara-Rojas, Fernando; Sánchez, Olivia; Kawasaki, Laura; Aguirre, Jesús

    2011-04-01

    Fungi utilize a phosphorelay system coupled to a MAP kinase module for sensing and processing environmental signals. In Aspergillus nidulans, response regulator SskA transmits osmotic and oxidative stress signals to the stress MAPK (SAPK) SakA. Using a genetic approach together with GFP tagging and molecular bifluorescence we show that SakA and ATF/CREB transcription factor AtfA define a general stress-signalling pathway that plays differential roles in oxidative stress responses during growth and development. AtfA is permanently localized in the nucleus, while SakA accumulates in the nucleus in response to oxidative or osmotic stress signals or during normal spore development, where it physically interacts with AtfA. AtfA is required for expression of several genes, the conidial accumulation of SakA and the viability of conidia. Furthermore, SakA is active (phosphorylated) in asexual spores, remaining phosphorylated in dormant conidia and becoming dephosphorylated during germination. SakA phosphorylation in spores depends on certain (SskA) but not other (SrrA and NikA) components of the phosphorelay system. Constitutive phosphorylation of SakA induced by the fungicide fludioxonil prevents both, germ tube formation and nuclear division. Similarly, Neurospora crassa SakA orthologue OS-2 is phosphorylated in intact conidia and gets dephosphorylated during germination. We propose that SakA-AtfA interaction regulates gene expression during stress and conidiophore development and that SAPK phosphorylation is a conserved mechanism to regulate transitions between non-growing (spore) and growing (mycelia) states. PMID:21320182

  19. Toroidal modeling of interaction between resistive wall mode and plasma flow

    CERN Document Server

    Liu, Yueqiang

    2013-01-01

    The non-linear interplay between the resistive wall mode (RWM) and the toroidal plasma flow is numerically investigated in a full toroidal geometry, by simultaneously solving the initial value problems for the n=1 RWM and the n=0 toroidal force balance equation. Here n is the toroidal mode number. The neoclassical toroidal viscous torque is identified as the major momentum sink that brakes the toroidal plasma flow during the non-linear evolution of the RWM. This holds for a mode that is initially either unstable or stable. For an initially stable RWM, the braking of the flow, and hence the eventual growth of the mode, depends critically on the initial perturbation amplitude.

  20. Toroidal cell and battery. [storage battery for high amp-hour load applications

    Science.gov (United States)

    Nagle, W. J. (Inventor)

    1981-01-01

    A toroidal storage battery designed to handle relatively high amp-hour loads is described. The cell includes a wound core disposed within a pair of toroidal channel shaped electrodes spaced apart by nylon insulator. The shape of the case electrodes of this toroidal cell allows a first planar doughnut shaped surface and the inner cylindrical case wall to be used as a first electrode and a second planar doughnut shaped surface and the outer cylindrical case wall to be used as a second electrode. Connectors may be used to stack two or more toroidal cells together by connecting substantially the entire surface area of the first electrode of a first cell to substantially the entire surface area of the second electrode of a second cell. The central cavity of each toroidal cell may be used as a conduit for pumping a fluid through the toroidal cell to thereby cool the cell.

  1. Kinetic resonance damping rate of the toroidal ion temperature gradient mode

    International Nuclear Information System (INIS)

    The linear damping rates of the toroidal ion temperature gradient (ηi) mode due to the toroidal resonance are calculated in the local kinetic limit. The well-known Landau contour method is generalized to treat the analytic continuation problem of the guiding center dispersion function in the toroidal resonance system where the resonance occurs from both the magnetic ΔB-curvature drift and the parallel ion transit drift. A detailed numerical analysis is presented for the dependence of the damping rate of the toroidal ηi mode on various parameters such as var-epsilon n, κy, and the trapped electron fraction. In addition, a consideration is presented on the decay problem of the ballistic response by the phase mixing in the toroidal system, which is directly related to the present damping problem of the wave normal modes by the toroidal resonance

  2. Axisymmetric magnetic fields in stars: relative strengths of poloidal and toroidal components

    OpenAIRE

    Braithwaite, J.

    2008-01-01

    In this third paper in a series on stable magnetic equilibria in stars, I look at the stability of axisymmetric field configurations and in particular at the relative strengths of the toroidal and poloidal components. Both toroidal and poloidal fields are unstable on their own, and stability is achieved by adding the two together in some ratio. I use Tayler's (1973) stability conditions for toroidal fields and other analytic tools to predict the range of stable ratios and then check these pre...

  3. PARTICLE-HOLE NATURE OF THE LIGHT HIGH-SPIN TOROIDAL ISOMERS

    Energy Technology Data Exchange (ETDEWEB)

    Staszczak, A. [Maria Curie-Sklodowska University, Poland; Wong, Cheuk-Yin [ORNL

    2015-01-01

    Nuclei under non-collective rotation with a large angular momentum above some threshold can assume a toroidal shape. In our previous work, we showed by using cranked Skyrme Hartree Fock approach that even even, N = Z, high-K, toroidal isomeric states may have general occurrences for light nuclei with 28 < A < 52. We present here some additional results and systematics on the particle-hole nature of these high-spin toroidal isomers.

  4. The vector potential of a circular cylindrical antenna in terms of a toroidal harmonic expansion

    Science.gov (United States)

    Selvaggi, Jerry; Salon, Sheppard; Chari, M. V. K.

    2008-08-01

    A toroidal harmonic expansion is developed which is used to represent the vector potential due to a circular cylindrical antenna with a rectangular cross section at any arbitrary point in space. The singular part of the antenna kernel is represented by an associated toroidal harmonic expansion and the analytic part of the kernel is represented by a binomial expansion. A simple example is given to illustrate the application of the toroidal expansion.

  5. Toroidal Spiral Nambu-Goto Strings around Higher-Dimensional Black Holes

    CERN Document Server

    Igata, Takahisa

    2009-01-01

    We present solutions of the Nambu-Goto equation for test strings in a shape of toroidal spiral in five-dimensional spacetimes. In particular, we show that stationary toroidal spirals exist around the five-dimensional Myers-Perry black holes. We also show the existence of innermost stationary toroidal spirals around the five-dimensional black holes like geodesic particles orbiting around four-dimensional black holes.

  6. Observation of non diffusive term of toroidal momentum transport in the JFT-2M tokamak

    International Nuclear Information System (INIS)

    Toroidal rotation velocity profiles are measured with multi-chord charge-exchange spectroscopy for the discharge that the neutral beams are interchanged from parallel (co) to anti-parallel (counter) to the direction of the plasma current. Transport analysis of toroidal momentum in the transient phase suggests the existence of non-diffusive term in the toroidal momentum transport. This non-diffusive term appears as spontaneous source of the toroidal momentum in the direction of anti-parallel to the plasma current. (author)

  7. The comparative analysis of the different mechanisms of toroidal rotation in tokamaks

    Energy Technology Data Exchange (ETDEWEB)

    Sabot, R. [Association Euratom-CEA, Centre d`Etudes Nucleaires de Cadarache, 13 - Saint-Paul-lez-Durance (France). Dept. de Recherches sur la Fusion Controlee; Parail, V. [Kurchatov Institute, Moscow (Russian Federation)

    1994-07-01

    The toroidal plasma rotation appears as one the possible mechanism for suppression of plasma turbulence. Several mechanisms are believed to contribute to the toroidal plasma rotation. The results of numerical simulation of the toroidal rotation on JET are presented, where are taken into consideration the following effects: the neoclassical viscosity due to banana and ripple trapped particles, the anomalous viscosity due to plasma turbulence, the momentum input by NBI (neutron beam injection) and ion momentum loss near the separatrix due to prompt ion losses. The NBI appeared to be the principal source of toroidal plasma rotation. 6 refs., 2 figs.

  8. Alpha particle destabilization of the toroidicity-induced Alfven eigenmodes

    International Nuclear Information System (INIS)

    The high frequency, low mode number toroidicity-induced Alfven eigenmodes (TAE) are shown to be driven unstable by the circulating and/or trapped α-particles through the wave-particle resonances. Satisfying the resonance condition requires that the α-particle birth speed vα ≥ vA/2|m-nq|, where vA is the Alfven speed, m is the poloidal model number, and n is the toroidal mode number. To destabilize the TAE modes, the inverse Landau damping associated with the α-particle pressure gradient free energy must overcome the velocity space Landau damping due to both the α-particles and the core electrons and ions. The growth rate was studied analytically with a perturbative formula derived from the quadratic dispersion relation, and numerically with the aid of the NOVA-K code. Stability criteria in terms of the α-particle beta βα, α-particle pressure gradient parameter (ω*/ωA) (ω* is the α-particle diamagnetic drift frequency), and (vα/vA) parameters will be presented for TFTR, CIT, and ITER tokamaks. The volume averaged α-particle beta threshold for TAE instability also depends sensitively on the core electron and ion temperature. Typically the volume averaged α-particle beta threshold is in the order of 10-4. Typical growth rates of the n=1 TAE mode can be in the order of 10-2ωA, where ωA=vA/qR. Other types of global Alfven waves are stable in D-T tokamaks due to toroidal coupling effects

  9. Edge magnetohydrodynamic instability studies in the Pegasus Toroidal Experiment

    Science.gov (United States)

    Bongard, Michael W.

    Peeling modes, an instability mechanism underlying deleterious Edge Localized Mode (ELM) activity in fusion-grade plasmas, are observed at the plasma edge in the PEGASUS Toroidal Experiment under conditions of high edge current density (Jedge(˜ 0.1 MA/m2) and low magnetic field (B ˜0.1 T) present at near-unity aspect ratio. Their macroscopic properties are measured using external Mirnov coil arrays, Langmuir probes, and high-speed visible imaging. The modest edge parameters and short pulse lengths of PEGASUS discharges permit direct measurement of the internal magnetic field structure with an insertable array of Hall-effect sensors, providing the current profile and its dynamical evolution on ELM-relevant timescales. Peeling modes generate coherent, edge-localized electromagnetic activity with low toroidal mode numbers n ≤ 3 and high poloidal mode numbers, in agreement with theoretical expectations of a low- n external kink structure. Coherent MHD fluctuation amplitudes are found to be strongly dependent on the experimentally measured J edge/B peeling instability drive, consistent with theory. An equilibrium reconstruction obtained during peeling activity with its current profile constrained by internal Hall measurements is used to test the predictions of analytic peeling stability theory and the ideal MHD stability model. Both approaches are in agreement with experiment, with the latter finding instability to an external kink. Peeling modes nonlinearly generate ELM-like, field-aligned filamentary structures. They detach from the edge and transiently accelerate radially outward, followed by propagation with constant velocity. Time-resolved Jedge measurements demonstrate that the filaments are formed from an initial current-hole perturbation and carry net toroidal currents If ˜ 100--200 A, less than 0.2% of the plasma current. Their constant-velocity radial motions are in qualitative agreement with rates given by electromagnetic blob transport theory.

  10. Kinetic extensions of magnetohydrodynamic models for axisymmetric toroidal plasmas

    International Nuclear Information System (INIS)

    A nonvariational kinetic-MHD stability code (NOVA-K) has been developed to integrate a set of non-Hermitian integro-differential eigenmode equations due to energetic particles for axisymmetric toroidal plasmas in a general flux coordinate system with an arbitrary Jacobian. The NOVA-K code employs the Galerkin method involving Fourier expansions in the generalized poloidal angle θ and generalized toroidal angle /zeta/ directions, and cubic-B spline finite elements in the radial /Psi/ direction. Extensive comparisons with the existing variational ideal MHD codes show that the ideal MHD version of the NOVA-K code converges faster and gives more accurate results. The NOVA-K code is employed to study the effects of energetic particles on MHD-type modes: the stabilization of ideal MHD internal kink modes and the excitation of ''fishbone'' internal kink modes; and the alpha particle destabilization of toroidicity-induced Alfven eigenmodes (TAE) via transit resonances. Analytical theories are also presented to help explain the NOVA-K results. For energetic trapped particles generated by neutral beam injection (NBI) or ion cyclotron resonant heating (ICRH), a stability window for the n = 1 internal kink mode in the hot particle beta space exists even in the absence of the core ion finite Larmor radius effect. On the other hand, the trapped alpha particles are found to have negligible effects on the stability of the n = 1 internal kink mode, but the circulating alpha particles can strongly destabilize TAE modes via inverse Landau damping associated with the spatial gradient of the alpha particle pressure. 60 refs., 24 figs., 1 tab

  11. Fabrication of toroidal composite pressure vessels. Final report

    International Nuclear Information System (INIS)

    A method for fabricating composite pressure vessels having toroidal geometry was evaluated. Eight units were fabricated using fibrous graphite material wrapped over a thin-walled aluminum liner. The material was wrapped using a machine designed for wrapping, the graphite material was impregnated with an epoxy resin that was subsequently thermally cured. The units were fabricated using various winding patterns. They were hydrostatically tested to determine their performance. The method of fabrication was demonstrated. However, the improvement in performance to weight ratio over that obtainable by an all metal vessel probably does not justify the extra cost of fabrication

  12. Nonlinear hybrid simulation of toroidicity-induced alfven eigenmode

    International Nuclear Information System (INIS)

    Gyrokinetic/Magnetohydrodynamics hybrid simulations have been carried out using MH3D-K code to study the nonlinear saturation of the toroidicity-induced Alfven eigenmode driven by energetic particles in a tokamak plasma. It is shown that the wave particle trapping is the nonlinear saturation mechanism for the parameters considered. The corresponding density profile flattening of hot particles is observed. The saturation amplitude is proportional to the square of linear growth rate. In addition to TAE modes, a new n = 1, m = 0 global Alfven eigenmode is shown to be excited by the energetic particles

  13. Free-boundary toroidal Alfvén eigenmodes

    Science.gov (United States)

    Chen, Eugene Y.; Berk, H. L.; Breizman, B.; Zheng, L. J.

    2011-05-01

    A numerical study is presented for the n = 1 free-boundary toroidal Alfvén eigenmodes (TAE) in tokamaks, which shows that there is considerable sensitivity of n = 1 modes to the position of the conducting wall. An additional branch of the TAE is shown to emerge from the upper continuum as the ratio of conducting wall radius to plasma radius increases. Such phenomena arise in plasma equilibria with both circular and shaped cross sections, where the shaped profile studied here is similar to that found in Alcator C-Mod.

  14. Results of the ITER toroidal field model coil project

    International Nuclear Information System (INIS)

    In the scope of the ITER EDA one of the seven largest projects was devoted to the development, manufacture and testing of a Toroidal Field Model Coil (TFMC). The industry consortium AGAN manufactured the TFMC based on on a conceptual design developed by the ITER EDA EU Home Team. The TFMC was completed and assembled in the test facility TOSKA of the Forschungszentrum Karlsruhe in the first half of 2001. The first testing phase started in June 2001 and lasted till October 2001. The first results have shown that the main goals of the project have been achieved

  15. Electromagnetic formulation of global gyrokinetic particle simulation in toroidal geometry

    International Nuclear Information System (INIS)

    The fluid-kinetic hybrid electron model for global electromagnetic gyrokinetic particle simulations has been formulated in toroidal geometry using magnetic coordinates, providing the capabilities to describe low frequency processes in electromagnetic turbulence with electron dynamics. In the limit of long wavelength and no parallel electric field our equations reduce to the ideal magnetohydrodynamic equations. The formulation has been generalized to include equilibrium flows. The equations for zonal components of electrostatic and vector potentials have been derived, demonstrating the electron screening of the zonal vector potential.

  16. Ceramic toroidal vacuum chamber for the ZT-40 experiment

    International Nuclear Information System (INIS)

    The design and fabrication of the large ceramic vacuum vessel now in use in the ZT-40 experiment are discussed. The torus has a major diameter of 228 cm, a minor diameter of 40 cm, and it is made of 99.5% pure alumina. The design includes a number of sapphire viewing windows as well as ceramic diagnostic and pump ports. Presented are several design features unique in toroidal chamber fabrication using segmented ceramics. The electrical and thermal insulation applied to this vessel is discussed as well as the handling technique used to accomplish final installation in the experiment

  17. Comments on structural types of toroidal carbon nanotubes

    CERN Document Server

    Chuang, Chern; Jin, Bih-Yaw

    2012-01-01

    We clarify the relationships between the eight structural types of toroidal carbon nanotubes (TCNTs), which can be identified as the eight corners of a cube of structural transformation. The four families with Dnh symmetry can be related by rim rotations, and the same is true for those with Dnd symmetries. These two sets are then connected by horizontal shiftings, thereby completing the cube. Moreover, we further point out that there are five more highly symmetric Dnh structural types that can be derived from performing the generalized Stone-Wales transformatoin on certain TCNTs with Dnh structural types.

  18. Hydraulic jumps in inhomogeneous strongly coupled toroidal dust flows

    Science.gov (United States)

    Piel, Alexander; Wilms, Jochen

    2016-07-01

    The inhomogeneous flow of strongly coupled dust particles in a toroidal particle trap with harmonic radial confinement is analyzed in the incompressible fluid limit. It is shown that the flow can spontaneously generate shock-like events, which are similar to the hydraulic jump in open channel flows. A definition of the Froude number for this model is given and the critical speed is recovered as the group velocity of surface waves. This hydraulic model is compared with molecular-dynamics simulations, which show that a sudden bifurcation of the flow lines and a localized temperature peak appear just at the point where the critical condition for the hydraulic jump is located.

  19. Experimental observation of crystalline particle flows in toroidal dust clouds

    Energy Technology Data Exchange (ETDEWEB)

    Wilms, Jochen, E-mail: wilms@physik.uni-kiel.de; Piel, Alexander [IEAP, Christian-Albrechts-Universität, D-24098 Kiel (Germany); Reichstein, Torben [IEAP, Christian-Albrechts-Universität, D-24098 Kiel (Germany); DME, Kiel University of Applied Sciences, Grenzstr. 3, D-24147 Kiel (Germany)

    2015-06-15

    The dust flow in a toroidal dust trap is studied experimentally. The flow is driven by the Hall component of the ion drag force in a magnetized plasma. Dust density waves are found in a torus with a large minor radius a, which allows for several wavelength, 2a>5λ, in the (mostly) radial direction of the ion flow. Beyond an intermediate state with radial sloshing oscillations, a crystalline dust flow with suppressed wave activity could be realized for 2a<2λ. The particles arrange themselves in distinct layers with hexagonal-like local order. Smooth transitions between states with different numbers of layers are found in the inhomogeneous flow.

  20. Stationary motion of a self gravitating toroidal incompressible liquid layer

    CERN Document Server

    Fusco, Giorgio; Oliva, Waldyr M

    2012-01-01

    We consider an incompressible fluid contained in a toroidal stratum which is only subjected to Newtonian self-attraction. Under the assumption of infinitesimal tickness of the stratum we show the existence of stationary motions during which the stratum is approximatly a round torus (with radii r, R and R>>r) that rotates around its axis and at the same time rolls on itself. Therefore each particle of the stratum describes an helix-like trajectory around the circumference of radius R that connects the centers of the cross sections of the torus.

  1. Acquisition system for the diagnostics data from a toroidal machine

    International Nuclear Information System (INIS)

    The data acquisition system 'ARIANE' has been conceived by the SIG (Service d'Ionique Generale), for physical measurements on the toroidal machines PETULA and WEGA, which were designed to study the H.F. heating of pulsed plasmas. These systems are constitued of electronic modules which permit them to be adapted to different kinds of measurements, either by analogue channels or by pulse counting. The programmation of these systems, are achieved, either by multiswitches accessible manually on front panels, or by a computer which performs the numerical computations

  2. System design of toroidal field power supply of CDD tokamak

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Zheng Zhi

    1996-12-01

    This report deals with system design of Toroidal Field Power Supply of CDD tokamak (CDD-TFPS). The general design philosophy and design variations are introduced. After the outline of CDD-TFPS, the short-circuit calculation, the evaluation of converter parameters, the compatibility of converter and line are carried out. the specifications of major components, semi-conductor devices and accessories are given. High attention is paid to protection system. The design of sub-control and grounding system are described too. Some more general material for power supply design are attached in appendices for reference. (author). 30 tabs., 21 figs.

  3. Meshing analysis of toroidal drive by computer algebra system

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    Presents the meshing analysis based on the Computer Algebra System to make it easier to deduce complex formulas while the expression of more complicated surface equations are visualized, by which, the contact line, mesh ing bordlines and undercut bordlines of toroidal drive are deduced, and the results obtained are consistent with the re sults discussed in literature[1] , and concludes that the absolute value of the induced normal curvature is usually smaller (less than 0.12, for example), and it increases as parameters ψ2, V and R increase, decreases as parameter r in creases, and hardly varies with W2, and the variation with a, i21 is not definite.

  4. Self-sustained magnetic braiding in toroidal plasmas

    International Nuclear Information System (INIS)

    Theory for the magnetic braiding in toroidal plasmas, which is caused by microscopic pressure-gradient-driven turbulence, is developed. When the pressure gradient exceeds a threshold, the self-sustaining of the magnetic braiding and enhanced anomalous transport occur. The balance between the nonlinear destabilization and nonlinear stabilization, which determines the stationary turbulence, is solved analytically for the case of interchange mode. The enhanced thermal conductivity and magnetic perturbation amplitude as well as the threshold pressure gradient are obtained. Cusp-type catastrophe is predicted, allowing the abrupt burst of magnetic perturbations. (author)

  5. Toroidal and poloidal momentum transport studies in tokamaks

    DEFF Research Database (Denmark)

    Tala, T.; Crombé, K.; Vries, P.C. de; Ferreira, J.; Mantica, P.; Peeters, A.G.; Andrew, Y.; Budny, R.; Corrigan, G.; Eriksson, A.; Garbet, X.; Giroud, C.; Hua, M.-D.; Nordman, H.; Naulin, Volker; Nave, M.F.F.; Parail, V.; Rantamäki, K.; Scott, B.D.; Strand, P.; Tardini, G.; Thyagaraja, A.; Weiland, J.; Zastrow, K.-D.

    The present status of understanding of toroidal and poloidal momentum transport in tokamaks is presented in this paper. Similar energy confinement and momentum confinement times, i.e. τE/τφ ≈ 1 have been reported on several tokamaks. It is more important though, to study the local transport both in...... the core and edge plasma separately as, for example, in the core plasma, a large scatter in the ratio of the local effective momentum diffusivity to the ion heat diffusivity χφeff/χi,eff among different tokamaks can be found. For example, the value of effective Prandtl number is typically around χφeff...

  6. Magnetic and drift surfaces in toroidal-plasma equilibria

    International Nuclear Information System (INIS)

    A method was developed for following magnetic field lines and guiding center orbits of isolated charged particles in toroidal plasma configurations with no spatial symmetries. The heart of the method lies in a divergence-free approximation to a numerical equilibrium magnetic field B that has been computed over a grid of points by the computer code of Betancourt and Garabedian. Considerations from the KAM theory for Hamiltonian systems and the results of our studies lead us to believe that the solenoidal property of B, del . B = 0 must be preserved to be able to follow trajectories in the torus adequately

  7. Symbolic derivation of bicycle kinematics with toroidal wheels

    Directory of Open Access Journals (Sweden)

    Wang Everett X.

    2015-01-01

    Full Text Available Bicycle kinematics with toroidal wheels is presented in this paper. Using symbolic mathematic tool Maple, we obtain two holonomic and four nonholonomic constraint equations due to front and rear wheels of a bicycle. We show that the two holonomic constraints cannot be expressed in quartic form for bicycle rear body pitch angle unless the minor (crown radius of the torus are the same for both the front and rear wheels. In addition, we show that all the constraints can be written in differential form, from which a constraint matrix is constructed, according to standard procedure for developing dynamics in robotics.

  8. Toroidal Imploding Detonation Wave Initiator for Pulse Detonation Engines

    OpenAIRE

    Jackson, S. I.; Shepherd, J. E.

    2007-01-01

    Imploding toroidal detonation waves were used to initiate detonations in propane–air and ethylene–air mixtures inside of a tube. The imploding wave was generated by an initiator consisting of an array of channels filled with acetylene–oxygen gas and ignited with a single spark. The initiator was designed as a low-drag initiator tube for use with pulse detonation engines. To detonate hydrocarbon–air mixtures, the initiator was overfilled so that some acetylene oxygen spilled into the tube. The...

  9. Application of toroidal multipoles to facilitate tokamak reactor studies

    International Nuclear Information System (INIS)

    A method of calculating the vacuum magnetic flux for plasma equilibrium over a range of aspect ratio A and major radius R is presented. Toroidal multipoles are used to fit the vacuum flux for a set of reference equilibria and the fitted moments are then used to parametrize the flux over the design space in A and R. An example is given in which the equilibrium flux for a D-shaped tokamak plasma is predicted and compared with the actual equilibrium code vacuum flux

  10. Brain-Specific Disruption of the eIF2α Kinase PERK Decreases ATF4 Expression and Impairs Behavioral Flexibility

    Directory of Open Access Journals (Sweden)

    Mimi A. Trinh

    2012-06-01

    Full Text Available Translational control depends on phosphorylation of eIF2α by PKR-like ER kinase (PERK. To examine the role of PERK in cognitive function, we selectively disrupted PERK expression in the adult mouse forebrain. In the prefrontal cortex (PFC of PERK-deficient mice, eIF2α phosphorylation and ATF4 expression were diminished and were associated with enhanced behavioral perseveration, decreased prepulse inhibition, reduced fear extinction, and impaired behavioral flexibility. Treatment with the glycine transporter inhibitor SSR504734 normalized eIF2α phosphorylation, ATF4 expression, and behavioral flexibility in PERK-deficient mice. Moreover, the expression levels of PERK and ATF4 were reduced in the frontal cortex of human patients with schizophrenia. Together, our findings reveal that PERK plays a critical role in information processing and cognitive function and that modulation of eIF2α phosphorylation and ATF4 expression may represent an effective strategy for treating behavioral inflexibility associated with several neurological disorders such as schizophrenia.

  11. The PERK/ATF4/LAMP3-arm of the unfolded protein response affects radioresistance by interfering with the DNA damage response

    NARCIS (Netherlands)

    Nagelkerke, A.; Bussink, J.; Kogel, A.J. van der; Sweep, F.C.; Span, P.N.

    2013-01-01

    BACKGROUND AND PURPOSE: Lysosome-associated membrane protein 3 (LAMP3) is induced by the PKR-like ER kinase (PERK)/activating transcription factor 4 (ATF4)-arm of the unfolded protein response (UPR) during hypoxia. LAMP3 has prognostic value in breast cancer patients treated with radiotherapy. Here,

  12. A Stress-Activated, p38 Mitogen-Activated Protein Kinase–ATF/CREB Pathway Regulates Posttranscriptional, Sequence-Dependent Decay of Target RNAs

    Science.gov (United States)

    Gao, Jun; Wagnon, Jacy L.; Protacio, Reine M.; Glazko, Galina V.; Beggs, Marjorie; Raj, Vinay

    2013-01-01

    Broadly conserved, mitogen-activated/stress-activated protein kinases (MAPK/SAPK) of the p38 family regulate multiple cellular processes. They transduce signals via dimeric, basic leucine zipper (bZIP) transcription factors of the ATF/CREB family (such as Atf2, Fos, and Jun) to regulate the transcription of target genes. We report additional mechanisms for gene regulation by such pathways exerted through RNA stability controls. The Spc1 (Sty1/Phh1) kinase-regulated Atf1-Pcr1 (Mts1-Mts2) heterodimer of the fission yeast Schizosaccharomyces pombe controls the stress-induced, posttranscriptional stability and decay of sets of target RNAs. Whole transcriptome RNA sequencing data revealed that decay is associated nonrandomly with transcripts that contain an M26 sequence motif. Moreover, the ablation of an M26 sequence motif in a target mRNA is sufficient to block its stress-induced loss. Conversely, engineered M26 motifs can render a stable mRNA into one that is targeted for decay. This stress-activated RNA decay (SARD) provides a mechanism for reducing the expression of target genes without shutting off transcription itself. Thus, a single p38-ATF/CREB signal transduction pathway can coordinately induce (promote transcription and RNA stability) and repress (promote RNA decay) transcript levels for distinct sets of genes, as is required for developmental decisions in response to stress and other stimuli. PMID:23732911

  13. Toroidal modelling of RMP response in ASDEX Upgrade: coil phase scan, q 95 dependence, and toroidal torques

    Science.gov (United States)

    Liu, Yueqiang; Ryan, D.; Kirk, A.; Li, Li; Suttrop, W.; Dunne, M.; Fischer, R.; Fuchs, J. C.; Kurzan, B.; Piovesan, P.; Willensdorfer, M.; the ASDEX Upgrade Team; the EUROfusion MST1 Team

    2016-05-01

    The plasma response to the vacuum resonant magnetic perturbation (RMP) fields, produced by the ELM control coils in ASDEX Upgrade experiments, is computationally modelled using the MARS-F/K codes (Liu et al 2000 Phys. Plasmas 7 3681, Liu et al 2008 Phys. Plasmas 15 112503). A systematic investigation is carried out, considering various plasma and coil configurations as in the ELM control experiments. The low q plasmas, with {{q}95}∼ 3.8 (q 95 is the safety factor q value at 95% of the equilibrium poloidal flux), responding to low n (n is the toroidal mode number) field perturbations from each single row of the ELM coils, generates a core kink amplification effect. Combining two rows, with different toroidal phasing, thus leads to either cancellation or reinforcement of the core kink response, which in turn determines the poloidal location of the peak plasma surface displacement. The core kink response is typically weak for the n  =  4 coil configuration at low q, and for the n  =  2 configuration but only at high q ({{q}95}∼ 5.5 ). A phase shift of around 60 degrees for low q plasmas, and around 90 degrees for high q plasmas, is found in the coil phasing, between the plasma response field and the vacuum RMP field, that maximizes the edge resonant field component. This leads to an optimal coil phasing of about 100 (‑100) degrees for low (high) q plasmas, that maximizes both the edge resonant field component and the plasma surface displacement near the X-point of the separatrix. This optimal phasing closely corresponds to the best ELM mitigation observed in experiments. A strong parallel sound wave damping moderately reduces the core kink response but has minor effect on the edge peeling response. For low q plasmas, modelling shows that both the resonant electromagnetic torque and the neoclassical toroidal viscous (NTV) torque (due to the presence of 3D magnetic field perturbations) contribute to the toroidal flow damping, in particular near the

  14. Predictive Simulations of ITER Including Neutral Beam Driven Toroidal Rotation

    Energy Technology Data Exchange (ETDEWEB)

    Halpern, Federico D.; Kritz, Arnold H.; Bateman, Glenn; Pankin, Alexei Y.; Budny, Robert V.; McCune, Douglas C.

    2008-06-16

    Predictive simulations of ITER [R. Aymar et al., Plasma Phys. Control. Fusion 44, 519 2002] discharges are carried out for the 15 MA high confinement mode (H-mode) scenario using PTRANSP, the predictive version of the TRANSP code. The thermal and toroidal momentum transport equations are evolved using turbulent and neoclassical transport models. A predictive model is used to compute the temperature and width of the H-mode pedestal. The ITER simulations are carried out for neutral beam injection (NBI) heated plasmas, for ion cyclotron resonant frequency (ICRF) heated plasmas, and for plasmas heated with a mix of NBI and ICRF. It is shown that neutral beam injection drives toroidal rotation that improves the confinement and fusion power production in ITER. The scaling of fusion power with respect to the input power and to the pedestal temperature is studied. It is observed that, in simulations carried out using the momentum transport diffusivity computed using the GLF23 model [R.Waltz et al., Phys. Plasmas 4, 2482 (1997)], the fusion power increases with increasing injected beam power and central rotation frequency. It is found that the ITER target fusion power of 500 MW is produced with 20 MW of NBI power when the pedesta temperature is 3.5 keV. 2008 American Institute of Physics. [DOI: 10.1063/1.2931037

  15. Kinetic and electromagnetic transport processes in toroidal devices

    International Nuclear Information System (INIS)

    A brief review of transport processes in toroidal devices is presented. Particular attention is given to radial transport of power by the Poynting's vector and kinetic electron flow. This work is primarily focused on the Reversed Field Pinch (RFP) which holds the added complexity of a dynamo process that sustains poloidal current in the edge region, where the toroidal field is reversed. The experimental observation of superthermal unidirectional electrons in the plasma edge of ZT-40M and HBTX1C is noted, and the rapid, nonclassical ion heating in RFPs is taken account of. Radial transport parallel to fluctuating magnetic field lines is deemed a likely candidate for both electromagnetic and kinetic energy transport. Two models are discussed and compared. It is concluded that electromagnetic transport using a local Ohm's law best describes nonclassical ion heating, and the transport of kinetic energy by long mean free path electrons best represents the half-Maxwellian of electrons observed in the edge of several RFPs. A nonlocal Ohm's law is essential for the kinetic electron model. 18 refs

  16. Dynamic processes in field-reversed-configuration compact toroids

    International Nuclear Information System (INIS)

    In this lecture, the dynamic processes involved in field-reversed configuration (FRC) formation, translation, and compression will be reviewed. Though the FRC is related to the field-reversed mirror concept, the formation method used in most experiments is a variant of the field-reversed Θ-pinch. Formation of the FRC eqilibrium occurs rapidly, usually in less than 20 μs. The formation sequence consists of several coupled processes: preionization; radial implosion and compression; magnetic field line closure; axial contraction; equilibrium formation. Recent experiments and theory have led to a significantly improved understanding of these processes; however, the experimental method still relies on a somewhat empirical approach which involves the optimization of initial preionization plasma parameters and symmetry. New improvements in FRC formation methods include the use of lower voltages which extrapolate better to larger devices. The axial translation of compact toroid plasmas offers an attractive engineering convenience in a fusion reactor. FRC translation has been demonstrated in several experiments worldwide, and these plasmas are found to be robust, moving at speeds up to the Alfven velocity over distances of up to 16 m, with no degradation in the confinement. Compact toroids are ideal for magnetic compression. Translated FRCs have been compressed and heated by imploding liners. Upcoming experiments will rely on external flux compression to heat a translater FRC at 1-GW power levels. 39 refs

  17. Last End Cap Toroid installation : The Pharaonic enterprise

    CERN Multimedia

    Arnaud Foussat

    After the successful and impressive transport feat from Building 191 to Point 1 was carried out by the Friderici crew on 28th June, the second and last Toroid End Cap, ECT-C, was transferred into the surface building, SX1, on 2nd July. The ECT-C was installed in the ATLAS cavern on the C-side on 12th July. As the person responsible for the project, in my opinion, one of the crucial points of this project was to design all the tooling and installation sequences taking into account the building infrastructure dimensional constraints. View of the ECT installation tooling and preparation for the ECT-C descent into the ATLAS 80m-shaft by the ATLAS magnet group and DBS teams. The movement of the 240-ton magnet and 12-m diameter toroid end-cap was achieved in collaboration with SCALES, a subcontractor company, using a hydraulic gantry able to lower the ECT inside the shaft by 5m below the floor level . This allowed the DBS team to attach the end-cap with the 2 x 140 tons overhead crane and lower it onto the c...

  18. Theoretical Analysis of the Electron Spiral Toroid Concept

    Science.gov (United States)

    Cambier, Jean-Luc; Micheletti, David A.; Bushnell, Dennis M. (Technical Monitor)

    2000-01-01

    This report describes the analysis of the Electron Spiral Toroid (EST) concept being promoted by Electron Power Systems Inc. (EPS). The EST is described as a toroidal plasma structure composed Of ion and electron shells. It is claimed that the EST requires little or no external confinement, despite the extraordinarily large energy densities resulting from the self-generating magnetic fields. The present analysis is based upon documentation made available by EPS, a previous description of the model by the Massachusetts Institute of Technology (MIT), and direct discussions with EPS and MIT. It is found that claims of absolute stability and large energy storage capacities of the EST concept have not been substantiated. Notably, it can be demonstrated that the ion fluid is fundamentally unstable. Although various scenarios for ion confinement were subsequently suggested by EPS and MIT, none were found to be plausible. Although the experimental data does not prove the existence of EST configurations, there is undeniable experimental evidence that some type of plasma structures whose characteristics remain to be determined are observed. However, more realistic theoretical models must first be developed to explain their existence and properties before applications of interest to NASA can he assessed and developed.

  19. Testing of the Toroidal Field model Coil (TFMC)

    International Nuclear Information System (INIS)

    The paper shortly describes the Toroidal Field Model Coil (TFMC) design, fabrication choices and issues with respect to technological and management aspects. The experience gained during the assembly and disassembly of the TFMC for phase 1 testing, as well as the assembly with the LCT coil for phase 2 testing will be reported. During phase 1 the TFMC was energised at 80 kA and was fast discharged several times without changes in the coil performances. The first test campaign has demonstrated the feasibility and operability of the ITER Toroidal Field coils including the joints. An in depth analysis of the test results will be presented in the paper. The goal for phase 2 testing is to determine the actual margins which have been achieved in the design and manufacture of the TFMC in selected areas. For this purpose, the TFMC will be operated beyond the design conditions in terms of current, temperature and parameters related to coil protection (discharge time constant, quench detection time). This second phase has started in September 2002 and will last about four months, therefore the test results can be used to optimise the ITER design, in particular on the conductors and insulation system. (author)

  20. Shear-Alfven dynamics of toroidally confined plasmas. Part A

    International Nuclear Information System (INIS)

    Recent developments in the stability theory of toroidally confined plasmas are reviewed, with the intention of providing a picture comprehensible to non-specialists. The review considers a class of low-frequency, electromagnetic disturbances that seem especially pertinent to modern high-temperature confinement experiments. It is shown that such disturbances are best unified and understood through consideration of a single, exact fluid moment: the shear-Alfven law. Appropriate versions of this law and its corresponding closure relations are derived - essentially from first principles - and applied in a variety of mostly, but not exclusively, linear contexts. Among the specific topics considered are: flux coordinates (including Hamada coordinates), the Newcomb solubility condition. Shafranov geometry, magnetic island evolution, reduced MHD and its generalizations, drift-kinetic electron response, classical tearing, twisting, and kink instabilities, pressure-modified tearing instability (Δ-critical), collisionless and semi-collisional tearing modes, the ballooning representation in general geometry, ideal ballooning instability, Mercier criterion, near-axis expansions, the second stability region, and resistive and kinetic ballooning modes. The fundamental importance of toroidal topology and curvature is stressed

  1. From toroidal to rod-like condensates of semiflexible polymers.

    Science.gov (United States)

    Hoang, Trinh Xuan; Giacometti, Achille; Podgornik, Rudolf; Nguyen, Nhung T T; Banavar, Jayanth R; Maritan, Amos

    2014-02-14

    The competition between toroidal and rod-like conformations as possible ground states for DNA condensation is studied as a function of the stiffness, the length of the DNA, and the form of the long-range interactions between neighboring molecules, using analytical theory supported by Monte Carlo simulations. Both conformations considered are characterized by a local nematic order with hexagonal packing symmetry of neighboring DNA molecules, but differ in global configuration of the chain and the distribution of its curvature as it wraps around to form a condensate. The long-range interactions driving the DNA condensation are assumed to be of the form pertaining to the attractive depletion potential as well as the attractive counterion induced soft potential. In the stiffness-length plane we find a transition between rod-like to toroid condensate for increasing stiffness at a fixed chain length L. Strikingly, the transition line is found to have a L(1/3) dependence irrespective of the details of the long-range interactions between neighboring molecules. When realistic DNA parameters are used, our description reproduces rather well some of the experimental features observed in DNA condensates. PMID:24527935

  2. Protection of toroidal field coils using multiple circuits

    International Nuclear Information System (INIS)

    The protection of toroidal field (TF) coils using multiple circuits is described. The discharge of a single-circuit TF system is given for purposes of definition. Two-circuit TF systems are analyzed and the results presented analytically and graphically. Induced currents, maximum discharge voltages, and discharge time constants are compared to the single-circuit system. Three-circuit TF systems are analyzed. In addition to induced currents, maximum discharge voltages, and time constants, several different discharge scenarios are included. The impacts of having discharge rates versus final maximum coil temperatures as requirements are examined. The out-of-plane forces which occur in the three-circuit system are analyzed using an approximate model. The analysis of multiplecircuit TF systems is briefly described and results for a Toroidal Fusion Core Experiment (TFCX) scale device are given based on computer analysis. The advantages and disadvantages of using multiple-circuit systems are summarized and discussed. The primary disadvantages of multiple circuits are the increased circuit complexity and potential for out-of-plane forces. These are offset by the substantial reduction in maximum discharge voltages, as well as other design options which become available when using multiple circuits

  3. ITER-hard Toroidal Field coil structural analysis

    International Nuclear Information System (INIS)

    The High Aspect Ratio Design (HARD) for the International Thermonuclear Experimental Reactor (ITER) has Toroidal Field (TF) coils that are farther out from the center of the Toroidal ring and more elongated than the previous design (CDA). These coils should see higher forces than in CDA and were designed accordingly. The objective of this work, conducted at LLNL and the MIT Plasma Fusion Center, was to determine whether stress levels in the ITER-HARD design are acceptable. A global finite element model, representing one of the coils, was modeled at MIT to obtain stresses and displacements both during operation of the TF coils alone, and during the End of Burn phase with TF and PF (Poloidal Field) coils operating. At LLNL, a detail model of the TF coil straight leg near the equator was used to obtain stresses and displacements during TF operation only. Further detailed analysis of the winding pack of this model was done to estimate stress concentrations in the conduit and insulation

  4. Pareto optimal design of sectored toroidal superconducting magnet for SMES

    Energy Technology Data Exchange (ETDEWEB)

    Bhunia, Uttam, E-mail: ubhunia@vecc.gov.in; Saha, Subimal; Chakrabarti, Alok

    2014-10-15

    Highlights: • The optimization approach minimizes both the magnet size and necessary cable length of a sectored toroidal SMES unit. • Design approach is suitable for low temperature superconducting cable suitable for medium size SMES unit. • It investigates coil parameters with respect to practical engineering aspects. - Abstract: A novel multi-objective optimization design approach for sectored toroidal superconducting magnetic energy storage coil has been developed considering the practical engineering constraints. The objectives include the minimization of necessary superconductor length and torus overall size or volume, which determines a significant part of cost towards realization of SMES. The best trade-off between the necessary conductor length for winding and magnet overall size is achieved in the Pareto-optimal solutions, the compact magnet size leads to increase in required superconducting cable length or vice versa The final choice among Pareto optimal configurations can be done in relation to other issues such as AC loss during transient operation, stray magnetic field at outside the coil assembly, and available discharge period, which is not considered in the optimization process. The proposed design approach is adapted for a 4.5 MJ/1 MW SMES system using low temperature niobium–titanium based Rutherford type cable. Furthermore, the validity of the representative Pareto solutions is confirmed by finite-element analysis (FEA) with a reasonably acceptable accuracy.

  5. Design study of toroidal traction CVT for electric vehicles

    Science.gov (United States)

    Raynard, A. E.; Kraus, J.; Bell, D. D.

    1980-01-01

    The development, evaluation, and optimization of a preliminary design concept for a continuously variable transmission (CVT) to couple the high-speed output shaft of an energy storage flywheel to the drive train of an electric vehicle is discussed. An existing computer simulation program was modified and used to compare the performance of five CVT design configurations. Based on this analysis, a dual-cavity full-toroidal drive with regenerative gearing is selected for the CVT design configuration. Three areas are identified that will require some technological development: the ratio control system, the traction fluid properities, and evaluation of the traction contact performance. Finally, the suitability of the selected CVT design concept for alternate electric and hybrid vehicle applications and alternate vehicle sizes and maximum output torques is determined. In all cases the toroidal traction drive design concept is applicable to the vehicle system. The regenerative gearing could be eliminated in the electric powered vehicle because of the reduced ratio range requirements. In other cases the CVT with regenerative gearing would meet the design requirements after appropriate adjustments in size and reduction gearing ratio.

  6. Incorporation of toroidal boundary conditions into program POISSON

    International Nuclear Information System (INIS)

    A technique is developed for introduction of a boundary condition applicable to relaxation computations for magnetic problems with axial symmetry and with no sources (currents, or magnetized material) external to the boundary. The procedure as described in this note is restricted to cases in which the (toroidal) boundary will surround completely the region of physical interest but will not encompass the axis of rotational symmetry. The technique accordingly provides the opportunity of economically excluding from the relaxation process regions of no direct concern in the immediate neighborhood of the symmetry axis and hence can have useful application to annular magnetic devices with axial symmetry. The procedure adopted makes use internally of the characteristic form of the vector-potential function, in a source-free region, when expressed in toroidal coordinates. The relevant properties of associated Legendre functions of half-integral degree are summarized in this connection and their introduction into the program POISSON is outlined. Results of some test cases are included, to illustrate the application of this technique for configurations with median-plane symmetry. 8 refs., 9 figs

  7. Cryogenic Characteristics of the ATLAS Barrel Toroid Superconducting Magnet

    CERN Document Server

    Pengo, R; Delruelle, N; Pezzetti, M; Pirotte, O; Passardi, Giorgio; Dudarev, A; ten Kate, H

    2008-01-01

    ATLAS, one of the experiments of the LHC accelerator under commissioning at CERN, is equipped with a large superconducting magnet the Barrel Toroid (BT) that has been tested at nominal current (20500 A). The BT is composed of eight race-track superconducting coils (each one weights about 45 tons) forming the biggest air core toroidal magnet ever built. By means of a large throughput centrifugal pump, a forced flow (about 10 liter/second at 4.5 K) provides the indirect cooling of the coils in parallel. The paper describes the results of the measurements carried out on the complete cryogenic system assembled in the ATLAS cavern situated 100 m below the ground level. The measurements include, among other ones, the static heat loads, i.e., with no or constant current in the magnet, and the dynamic ones, since additional heat losses are produced, during the current ramp-up or slow dump, by eddy currents induced on the coil casing.

  8. Time-Dependent of Accretion Flow with Toroidal Magnetic Field

    CERN Document Server

    Khesali, Alireza

    2008-01-01

    In the present study time evolution of quasi-spherical polytropic accretion flow with toroidal magnetic field was investigated. The study especially focused the astrophysically important case in which the adiabatic exponent $\\gamma=5/3$. In this scenario, it was assumed that the angular momentum transport is due to viscous turbulence and used $\\alpha$-prescription for kinematic coefficient of viscosity. The equations of accretion flow are solved in a simplified one-dimensional model that neglects the latitudinal dependence of the flow. In order to solve the integrated equations which govern the dynamical behavior of the accretion flow, self-similar solution was used. The solution provides some insight into the dynamics of quasi-spherical accretion flow and avoids many of the strictures of the steady self-similar solution. The effect of the toroidal magnetic field is considered with additional variable $\\beta[=p_{mag}/p_{gas}]$, where $p_{mag}$ and $p_{gas}$ are the magnetic and gas pressure, respectively. The...

  9. Toroidal High-β Experiments in Compact Axisymmetric Configurations

    International Nuclear Information System (INIS)

    The confinement of plasmas heated by fast-rising (B/B ≈ 1 JJS) and confined by slowly decaying (|B/B| > 1 ms) magnetic fields is studied in axisymmetric toroidal configurations. Small aspect ratios R/a (R = major radius, a = characteristic minor dimension) are chosen to reach relatively high current densities and to confine plasmas of higher S below the Kruskal-Shafranov (K.S.) limit. In a first experiment (Helical Hard-core Thetapinch), plasmas with temperatures T ≈ 20 eV, densities n > 1016 cm-3 and strongly elliptical (typically b/a = 3) cross-sections are produced at the end of the fast compression. By adjusting the voltages and currents of the hard-core and the theta coil, and the, time-delay between switching the banks, R can be varied and the net plasma momentum in r direction can be made ≈ 0 at the end of the dynamic phase. Slower variations of R, resulting from the diffusion of the toroidal field into the plasma (β decreases to 15% in a few μs) and from the contraction of the plasma cross-section in the z-direction occur later. They can be controlled by programming the hard-core current. Theoretical results on the equilibrium plasma configuration agree with the result of magnetic-probe and optical measurements which further indicate some triangular deformation of the plasma cross-section. Outside the plasma, a vacuum magnetic field configuration is observed. The angle of rotational transform ℓ was varied by changing R and the ellipticity; the plasma appears hydromagnetically stable when q = 2 π/ℓ > 2.5. The observed confinement time (≈ 30 μs) agrees then with the decay time of the toroidal plasma current and can be explained by the relatively low plasma temperature. A second experiment is being built to study the high-fi stability limit in a torus with circular cross-section and larger dimensions (R = 25 cm, rw = 10 cm). The toroidal magnetic field (≤ 10 kG) and the discharge current rise simultaneously in 1.6 us. It will be attempted to

  10. Calculation of modification to the toroidal magnetic field of the Tokamak Novillo. Part II; Calculo de modificacion al campo magnetico toroidal del Tokamak nivillo. Parte II

    Energy Technology Data Exchange (ETDEWEB)

    Melendez L, L.; Chavez A, E.; Colunga S, S.; Valencia A, R.; Lopez C, R.; Gaytan G, E

    1992-03-15

    In a cylindrical magnetic topology. the confined plasma experiences 'classic' collisional transport phenomena. When bending the cylinder with the purpose of forming a toro, the magnetic field that before was uniform now it has a radial gradient which produces an unbalance in the magnetic pressure that is exercised on the plasma in the transverse section of the toro. This gives place to transport phenomena call 'neo-classicist'. In this work the structure of the toroidal magnetic field produced by toroidal coils of triangular form, to which are added even of coils of compensation with form of half moon is analyzed. With this type of coils it is looked for to minimize the radial gradient of the toroidal magnetic field. The values and characteristics of B (magnetic field) in perpendicular planes to the toro in different angular positions in the toroidal direction, looking for to cover all the cases of importance are exhibited. (Author)

  11. Bootstrap current in toroidal systems in the presence of a nonuniform radial electric field

    International Nuclear Information System (INIS)

    The sheared toroidal rotation driven by non-uniform radial electric field can essentially affect on a bootstrap current profile near the edge E-shear layer in the toroidal systems. The high Eγ and pressure gradients would generate the strong peaking off-axis bootstrap current and naturally sustain the hollow current density profile. (author)

  12. Investigation of toroidal acceleration and potential acceleration forces in EAST and J-TEXT plasmas

    CERN Document Server

    Wang, Fudi; Pan, Xiayun; Cheng, Zhifeng; Chen, Jun; Cao, Guangming; Wang, Yuming; Han, Xiang; Li, Hao; Wu, Bin; Chen, Zhongyong; Bitter, Manfred; Hill, Kenneth; Rice, John; Morita, Shigeru; Li, Yadong; Zhuang, Ge; Ye, Minyou; Wan, Baonian; Shi, Yuejiang

    2014-01-01

    In order to produce intrinsic rotation, bulk plasmas must be collectively accelerated by the net force exerted on them, which results from both driving and damping forces. So, to study the possible mechanisms of intrinsic rotation generation, it is only needed to understand characteristics of driving and damping terms because the toroidal driving and damping forces induce net acceleration which generates intrinsic rotation. Experiments were performed on EAST and J-TEXT for ohmic plasmas with net counter- and co-current toroidal acceleration generated by density ramping up and ramping down. Additionally on EAST, net co-current toroidal acceleration was also formed by LHCD or ICRF. For the current experimental results, toroidal acceleration was between - 50 km/s^2 in counter-current direction and 70 km/s^2 in co-current direction. According to toroidal momentum equation, toroidal electric field (E\\-(\\g(f))), electron-ion toroidal friction, and toroidal viscous force etc. may play roles in the evolution of toroi...

  13. Development of a Turn-by-Turn Beam Position Monitoring System for Multiple Bunch Operation of the ATF Damping Ring

    CERN Document Server

    Burrows, P N; Kraljevic, N Blaskovic; Christian, G B; Davis, M R; Perry, C; Apsimon, R J; Constance, B; Gerbershagen, A; Resta-Lopez, J

    2012-01-01

    An FPGA-based monitoring system has been developed to study multi-bunch beam instabilities in the damping ring (DR) of the KEK Accelerator Test Facility (ATF). The system utilises a stripline beam position monitor (BPM) and single-stage down-mixing BPM processor. The system is designed to record the horizontal and/or vertical positions of up to three bunches in the DR with c. 150ns bunch spacing, or the head bunch of up to three trains in a multi-bunch mode with a bunch spacing of 5.6 ns. The FPGA firmware and data acquisition software allow the recording of turnby-turn data. An overview of the system and performance results will be presented.

  14. Beam emittance and the effects of the rf, space charge and wake fields: Application to the ATF photoelectron beam

    International Nuclear Information System (INIS)

    Laser driven photoelectron guns are of interest for use in new methods of accelerations, future development of Linear Colliders and new experiments such as Free Electron laser (IFEL). Such guns are potential source of low emittance-high current and short bunch length electron beams, where the emitted electrons are accelerated quickly to a relativistic energy by a strong rf, electric field in the cavity. We present a brief overview of the beam dynamic studies, e.g. emittance for the Brookhaven National Laboratory (BNL) ATF high brightness photocathode radio frequency gun (now in operation), and show the effects of the rf, Space Charge, and Wake fields on the photoelectrons. 4 refs., 7 figs

  15. The Experiment of Modulated Toroidal Current on HT-7 and HT-6M Tokamak

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    The Experiments of Modulated Toroidal Current were done on the HT-6M tokamakand HT-7 superconducting tokamak. The toroidal current was modulated by programming theOhmic heating field. Modulation of the plasma current has been used successfully to suppressMHD activity in discharges near the density limit where large MHD m = 2 tearing modes weresuppressed by sufficiently large plasma current oscillations. The improved Ohmic confinementphase was observed during modulating toroidal current (MTC) on the Hefei Tokamak-6M (HT-6M) and Hefei superconducting Tokamak-7 (HT-7). A toroidal frequency-modulated current,induced by a modulated loop voltage, was added on the plasma equilibrium current. The ratio ofA.C. amplitude of plasma current to the main plasma current △Ip/Ip is about 12% ~ 30%. Thedifferent formats of the frequency-modulated toroidal current were compared.

  16. Toroidal high-spin isomers in light nuclei with N not equal to Z

    CERN Document Server

    Staszczak, Andrzej

    2014-01-01

    The combined considerations of both the bulk liquid-drop-type behavior and the quantized aligned rotation with cranked Skyrme-Hartree-Fock approach revealed previously that even-even, N=Z, toroidal high-spin isomeric states have general occurrences for light nuclei with A between 28 and 52. We find that in this mass region there are in addition N not equal to Z toroidal high-spin isomers when the single-particle shells for neutrons and protons occur at the same cranked frequency $\\hbar \\omega$. Examples of N not equal to Z toroidal high-spin isomers, $^{36}_{16}$S$_{20}$($I$=74$\\hbar$) and $^{40}_{18}$Ar$_{22}$($I$=80,102$\\hbar$), are located and examined. The systematic properties of these N not equal to Z toroidal high-spin isomers fall into the same regular (muti-particle)-(muti-hole) patterns as other N=Z toroidal high-spin isomers.

  17. Simulation study of toroidal flow generation of minority ions by local ICRF heating

    International Nuclear Information System (INIS)

    The toroidal flow generation of minority ions by the local ion cyclotron range of frequencies (ICRF) heating is investigated in a tokamak plasma by applying the GNET code, which can solve the drift kinetic equation in the 5-D phase space. An asymmetry of velocity distribution function in the parallel direction is found and two types of toroidal averaged flow of minority ions are observed. One is the sheared flow near the RF power absorption region depending on the sign of k∥, and the other is the toroidal flow, which is larger than the previous one, independent of the sign of k∥. It is found that the k∥-sign-independent toroidal flow is generated by the net toroidal motion of energetic tail ions and that the k∥-sign-dependent flow is related to the mechanism proposed by Ohkawa. (author)

  18. Matter in the form of toroidal electromagnetic vortices

    Science.gov (United States)

    Hagen, Wilhelm F.

    2015-09-01

    The creation of charged elementary particles from neutral photons is explained as a conversion process of electromagnetic (EM) energy from linear to circular motion at the speed of light into two localized, toroidal shaped vortices of trapped EM energy that resist change of motion, perceptible as particles with inertia and hence mass. The photon can be represented as a superposition of left and right circular polarized transverse electric fields of opposite polarity originating from a common zero potential axis, the optical axis of the photon. If these components are separated by interaction with a strong field (nucleon) they would curl up into two electromagnetic vortices (EMV) due to longitudinal magnetic field components forming toroids. These vortices are perceptible as opposite charged elementary particles e+/- . These spinning toroids generate extended oscillating fields that interact with stationary field oscillations. The velocity-dependent frequency differences cause beat signals equivalent to matter waves, leading to interference. The extended fields entangled with every particle explain wave particle duality issues. Spin and magnetic moment are the natural outcome of these gyrating particles. As the energy and hence mass of the electron increases with acceleration so does its size shrink proportional to its reduced wavelength. The artificial weak and strong nuclear forces can be easily explained as different manifestations of the intermediate EM forces. The unstable neutron consists of a proton surrounded by a contracted and captured electron. The associated radial EM forces represent the weak nuclear force. The deuteron consists of two axially separated protons held together by a centrally captured electron. The axial EM forces represent the strong nuclear force, providing stability for "neutrons" only within nucleons. The same principles were applied to determine the geometries of force-balanced nuclei. The alpha-particle emerges as a very compact

  19. 3D toroidal physics: testing the boundaries of symmetry breaking

    Science.gov (United States)

    Spong, Don

    2014-10-01

    Toroidal symmetry is an important concept for plasma confinement; it allows the existence of nested flux surface MHD equilibria and conserved invariants for particle motion. However, perfect symmetry is unachievable in realistic toroidal plasma devices. For example, tokamaks have toroidal ripple due to discrete field coils, optimized stellarators do not achieve exact quasi-symmetry, the plasma itself continually seeks lower energy states through helical 3D deformations, and reactors will likely have non-uniform distributions of ferritic steel near the plasma. Also, some level of designed-in 3D magnetic field structure is now anticipated for most concepts in order to lead to a stable, steady-state fusion reactor. Such planned 3D field structures can take many forms, ranging from tokamaks with weak 3D ELM-suppression fields to stellarators with more dominant 3D field structures. There is considerable interest in the development of unified physics models for the full range of 3D effects. Ultimately, the questions of how much symmetry breaking can be tolerated and how to optimize its design must be addressed for all fusion concepts. Fortunately, significant progress is underway in theory, computation and plasma diagnostics on many issues such as magnetic surface quality, plasma screening vs. amplification of 3D perturbations, 3D transport, influence on edge pedestal structures, MHD stability effects, modification of fast ion-driven instabilities, prediction of energetic particle heat loads on plasma-facing materials, effects of 3D fields on turbulence, and magnetic coil design. A closely coupled program of simulation, experimental validation, and design optimization is required to determine what forms and amplitudes of 3D shaping and symmetry breaking will be compatible with future fusion reactors. The development of models to address 3D physics and progress in these areas will be described. This work is supported both by the US Department of Energy under Contract DE

  20. Proceedings of the third symposium on the physics and technology of compact toroids in the magnetic fusion energy program

    International Nuclear Information System (INIS)

    This document contains papers contributed by the participants of the Third Symposium on Physics and Technology of Compact Toroids in the Magnetic Fusion Energy Program. Subjects include reactor aspects of compact toroids, energetic particle rings, spheromak configurations (a mixture of toroidal and poloidal fields), and field-reversed configurations